Sugiyamaella lignohabitans strain CBS 10342 chromosome C, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Trichomonascaceae; Sugiyamaella.
Complete genome sequence and transcriptome regulation of the pentose utilising yeast Sugiyamaella lignohabitans
Submitted (25-OCT-2016) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (18-FEB-2016) Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna 1190, Austria
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP014500.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.
ubiquinol--cytochrome-c reductase catalytic subunit RIP1
similar to AA sequence:KEGG_Orthology:K00411
Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 3036836]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0051537 - 2 iron, 2 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016679 - oxidoreductase activity, acting on diphenols and related substances as donors [Evidence IEA]; GO_function: GO:0008121 - ubiquinol-cytochrome-c reductase activity [Evidence IEA,IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 3036836]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 3036836]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
mitogen-activated protein kinase kinase kinase STE11
similar to AA sequence:KEGG_Orthology:K11228
similar to AA sequence:KEGG_Orthology:K09503
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; GO_component: GO:0072380 - TRC complex [Evidence IDA] [PMID 20850366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 1869583]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 8144572]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IDA] [PMID 1869583]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 1400408]; GO_function: GO:0001671 - ATPase activator activity [Evidence IDA] [PMID 15342786]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 9774392]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 10567418]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15252059]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 15342786]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 9674429]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1473150]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IMP] [PMID 1729605]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0009408 - response to heat [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
tyrosine/serine/threonine protein phosphatase MSG5
similar to AA sequence:KEGG_Orthology:K11240
similar to AA sequence:KEGG_Orthology:K17786
Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21944719]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 21987634]; GO_component: GO:0061617 - MICOS complex [Evidence IDA] [PMID 22009199]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0044284 - mitochondrial crista junction [Evidence IDA] [PMID 22009199]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 21987634]; GO_process: GO:0042407 - cristae formation [Evidence IMP] [PMID 22009199]
Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9726978]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11120744]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IGI] [PMID 11120744]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 10341420]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,IMP] [PMID 9726978]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015891 - siderophore transport [Evidence IMP] [PMID 9726978]
CCR4-NOT core DEDD family RNase subunit POP2
similar to AA sequence:KEGG_Orthology:K12581
mitogen-activated protein kinase kinase kinase SSK2
similar to AA sequence:KEGG_Orthology:K11230
similar to AA sequence:KEGG_Orthology:K05012
Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15710404]; GO_component: GO:0005797 - Golgi medial cisterna [Evidence IDA] [PMID 9614122]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0034707 - chloride channel complex [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 17662057]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15710404]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 17662057]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17662057]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0005254 - chloride channel activity [Evidence IEA]; GO_function: GO:0005216 - ion channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IEA]; GO_function: GO:0005247 - voltage-gated chloride channel activity [Evidence IDA] [PMID 12074596]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9614122]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9520490]; GO_process: GO:1902476 - chloride transmembrane transport [Evidence IEA]; GO_process: GO:0006821 - chloride transport [Evidence IEA,IEA]; GO_process: GO:0034220 - ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0044070 - regulation of anion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IMP] [PMID 12090248]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 15020461]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15020461]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 21429936]; GO_process: GO:0040008 - regulation of growth [Evidence IMP] [PMID 2204680]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 12090248]; GO_process: GO:0009651 - response to salt stress [Evidence IMP] [PMID 12090248]
hexaprenyldihydroxybenzoate methyltransferase
O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 10419476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 10760477]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008425 - 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Evidence IEA]; GO_function: GO:0061543 - 3-demethylubiquinone-6 3-O-methyltransferase activity [Evidence IMP] [PMID 10419476]; GO_function: GO:0008689 - 3-demethylubiquinone-9 3-O-methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IEA]; GO_function: GO:0004395 - hexaprenyldihydroxybenzoate methyltransferase activity [Evidence IMP] [PMID 1885593]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IDA] [PMID 10419476]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 1885593]
dolichyl-phosphate-mannose-protein mannosyltransferase PMT1
similar to AA sequence:KEGG_Orthology:K00728
Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8955402]; GO_function: GO:0015665 - alcohol transmembrane transporter activity [Evidence IMP] [PMID 2405251]; GO_function: GO:0022890 - inorganic cation transmembrane transporter activity [Evidence IMP] [PMID 8955402]; GO_process: GO:0006812 - cation transport [Evidence IMP] [PMID 8955402]; GO_process: GO:0015850 - organic hydroxy compound transport [Evidence IMP] [PMID 2405251]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05531
Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IDA] [PMID 10037752]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0000917 - barrier septum assembly [Evidence IMP] [PMID 16034811]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 10037752]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 23210626]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8991513]
similar to AA sequence:KEGG_Orthology:K08286
Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
translation initiation factor eIF2B subunit alpha
similar to AA sequence:KEGG_Orthology:K03239
Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IMP] [PMID 8099443]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA] [PMID 8336705]; GO_component: GO:0005851 - eukaryotic translation initiation factor 2B complex [Evidence IDA,IPI] [PMID 8506384]; GO_component: GO:0032045 - guanyl-nucleotide exchange factor complex [Evidence IDA] [PMID 8506384]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 8099443]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IGI,IMP,IPI] [PMID 8887689]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IMP] [PMID 9032257]; GO_function: GO:0005085 - guanyl-nucleotide exchange factor activity [Evidence IDA] [PMID 8506384]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IMP] [PMID 8099443]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 8336705]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 8099443]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA] [PMID 8506384]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IPI] [PMID 8887689]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IMP] [PMID 9032257]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14721
RNA polymerase III subunit C37; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 10611227]; GO_component: GO:0005666 - DNA-directed RNA polymerase III complex [Evidence IDA] [PMID 3905793]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0001056 - RNA polymerase III activity [Evidence IDA] [PMID 3905793]; GO_process: GO:0042797 - tRNA transcription from RNA polymerase III promoter [Evidence IDA] [PMID 3905793]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14806
Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9582098]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9582098]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11253
Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage; GO_component: GO:0043505 - centromere-specific nucleosome [Evidence IDA] [PMID 22693454]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0070911 - global genome nucleotide-excision repair [Evidence IMP] [PMID 21460225]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI] [PMID 19917722]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 16002464]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]
similar to AA sequence:KEGG_Orthology:K11254
Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000788 - nuclear nucleosome [Evidence TAS] [PMID 2275823]; GO_component: GO:0000786 - nucleosome [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence TAS] [PMID 2275823]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence TAS] [PMID 2275823]; GO_process: GO:0034729 - histone H3-K79 methylation [Evidence IMP] [PMID 18158898]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0043935 - sexual sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 20713519]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
similar to AA sequence:KEGG_Orthology:K01807
Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004751 - ribose-5-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0004751 - ribose-5-phosphate isomerase activity [Evidence IMP,ISS] [PMID 8929392]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IGI] [PMID 8929392]; GO_process: GO:0009052 - pentose-phosphate shunt, non-oxidative branch [Evidence IEA]; GO_process: GO:0008615 - pyridoxine biosynthetic process [Evidence IMP] [PMID 14690456]
similar to AA sequence:KEGG_Orthology:K12393
Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex; GO_component: GO:0030121 - AP-1 adaptor complex [Evidence IPI,ISS] [PMID 10564262]; GO_component: GO:0030131 - clathrin adaptor complex [Evidence IEA]; GO_component: GO:0030665 - clathrin-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005905 - coated pit [Evidence IEA,IEA]; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0030276 - clathrin binding [Evidence IPI,ISS] [PMID 10564262]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IMP] [PMID 17003107]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IPI,ISS] [PMID 10564262]
Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane; GO_component: GO:0005740 - mitochondrial envelope [Evidence IDA] [PMID 9111353]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000964 - mitochondrial RNA 5'-end processing [Evidence IMP] [PMID 18086665]; GO_process: GO:0000964 - mitochondrial RNA 5'-end processing [Evidence IMP] [PMID 9111353]
Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16850348]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 10869563]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 10869563]
similar to AA sequence:KEGG_Orthology:K11275
Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 22586276]; GO_component: GO:0000788 - nuclear nucleosome [Evidence IPI] [PMID 11574687]; GO_component: GO:0000786 - nucleosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9046096]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IPI] [PMID 11574687]; GO_process: GO:0030261 - chromosome condensation [Evidence IMP] [PMID 22586276]; GO_process: GO:0045910 - negative regulation of DNA recombination [Evidence IGI,IMP] [PMID 12820979]; GO_process: GO:0031936 - negative regulation of chromatin silencing [Evidence IGI] [PMID 19017647]; GO_process: GO:0006334 - nucleosome assembly [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 11574687]
Putative transcription factor; has homolog in Kluyveromyces lactis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K04486
Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004401 - histidinol-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004401 - histidinol-phosphatase activity [Evidence IMP] [PMID 14190241]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0000105 - histidine biosynthetic process [Evidence IMP] [PMID 14190241]
similar to AA sequence:KEGG_Orthology:K01881
Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004827 - proline-tRNA ligase activity [Evidence IDA] [PMID 16864571]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006433 - prolyl-tRNA aminoacylation [Evidence IDA] [PMID 16864571]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01893
Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IC] [PMID 9605503]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004816 - asparagine-tRNA ligase activity [Evidence IDA,ISS] [PMID 9605503]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006421 - asparaginyl-tRNA aminoacylation [Evidence IDA,IGI,ISS] [PMID 9605503]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17738
Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 9268358]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0008670 - 2,4-dienoyl-CoA reductase (NADPH) activity [Evidence IDA,ISS] [PMID 9268358]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP,IMP] [PMID 7969036]; GO_process: GO:0009062 - fatty acid catabolic process [Evidence IDA,ISS] [PMID 9268358]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
proteasome core particle subunit alpha 6
similar to AA sequence:KEGG_Orthology:K02725
Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 9087403]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IC] [PMID 9087403]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 9087403]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0005839 - proteasome core complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IEA]; GO_component: GO:0019773 - proteasome core complex, alpha-subunit complex [Evidence IDA] [PMID 9087403]; GO_component: GO:0034515 - proteasome storage granule [Evidence IDA] [PMID 18504300]; GO_function: GO:0004175 - endopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004298 - threonine-type endopeptidase activity [Evidence IEA,IEA]; GO_process: GO:0010499 - proteasomal ubiquitin-independent protein catabolic process [Evidence IDA] [PMID 19162040]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 11545745]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 19029916]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 11157978]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IPI] [PMID 11157978]
similar to AA sequence:KEGG_Orthology:K15631
similar to AA sequence:KEGG_Orthology:K08770
Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC] [PMID 8982460]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0043008 - ATP-dependent protein binding [Evidence TAS] [PMID 8982460]; GO_function: GO:0031386 - protein tag [Evidence ISS] [PMID 3038523]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence TAS] [PMID 8982460]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016579 - protein deubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0006513 - protein monoubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0000209 - protein polyubiquitination [Evidence TAS] [PMID 8982460]; GO_process: GO:0016567 - protein ubiquitination [Evidence IMP] [PMID 8035826]
similar to AA sequence:KEGG_Orthology:K01858
Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004512 - inositol-3-phosphate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004512 - inositol-3-phosphate synthase activity [Evidence IMP] [PMID 7016881]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006021 - inositol biosynthetic process [Evidence IMP] [PMID 7016881]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IDA] [PMID 9693366]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005871 - kinesin complex [Evidence IEA]; GO_component: GO:0005871 - kinesin complex [Evidence TAS] [PMID 9153752]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008017 - microtubule binding [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence IEA]; GO_function: GO:0003777 - microtubule motor activity [Evidence TAS] [PMID 9153752]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007018 - microtubule-based movement [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007026 - negative regulation of microtubule depolymerization [Evidence IMP] [PMID 9693366]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IMP] [PMID 9693366]
similar to AA sequence:KEGG_Orthology:K17945
Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 9864365]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 9864365]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0003786 - actin lateral binding [Evidence TAS] [PMID 9153752]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 9864365]; GO_process: GO:0007015 - actin filament organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0008154 - actin polymerization or depolymerization [Evidence TAS] [PMID 10652251]; GO_process: GO:0007118 - budding cell apical bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0030010 - establishment of cell polarity [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence TAS] [PMID 10652251]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0000011 - vacuole inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence TAS] [PMID 10652251]
similar to AA sequence:KEGG_Orthology:K11262
Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog, HFA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 9438137]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003989 - acetyl-CoA carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0003989 - acetyl-CoA carboxylase activity [Evidence IMP,ISS] [PMID 8098706]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence ISS] [PMID 1350093]; GO_function: GO:0004075 - biotin carboxylase activity [Evidence IMP] [PMID 6108218]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0042759 - long-chain fatty acid biosynthetic process [Evidence IMP] [PMID 6103540]; GO_process: GO:2001295 - malonyl-CoA biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence TAS] [PMID 9442897]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]
Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006094 - gluconeogenesis [Evidence IEA]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13721
Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence ISS] [PMID 8100228]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IMP] [PMID 8100228]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8100228]
similar to AA sequence:KEGG_Orthology:K12767
phosphopantothenoylcysteine decarboxylase complex subunit SIS2
Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IC,IPI] [PMID 9636153]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7705654]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 9636153]; GO_component: GO:0071513 - phosphopantothenoylcysteine decarboxylase complex [Evidence IDA] [PMID 19915539]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004633 - phosphopantothenoylcysteine decarboxylase activity [Evidence IDA,IMP] [PMID 19915539]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IEA]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IDA] [PMID 9636153]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IGI] [PMID 10022927]; GO_process: GO:0009651 - response to salt stress [Evidence IGI,IMP] [PMID 9636153]
similar to AA sequence:KEGG_Orthology:K06654
Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling; GO_component: GO:0000307 - cyclin-dependent protein kinase holoenzyme complex [Evidence IPI] [PMID 8108735]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9853758]; GO_function: GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity [Evidence IDA] [PMID 8108735]; GO_function: GO:0019901 - protein kinase binding [Evidence IEA]; GO_process: GO:0006875 - cellular metal ion homeostasis [Evidence IMP] [PMID 20429018]; GO_process: GO:0050849 - negative regulation of calcium-mediated signaling [Evidence IGI] [PMID 16455487]; GO_process: GO:0016242 - negative regulation of macroautophagy [Evidence IMP] [PMID 20417603]; GO_process: GO:0045936 - negative regulation of phosphate metabolic process [Evidence IGI] [PMID 3915785]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 3915785]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IEA]; GO_process: GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity [Evidence IDA] [PMID 8108735]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 16455487]
ethanolamine-phosphate cytidylyltransferase
similar to AA sequence:KEGG_Orthology:K00967
Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004306 - ethanolamine-phosphate cytidylyltransferase activity [Evidence IEA]; GO_function: GO:0004306 - ethanolamine-phosphate cytidylyltransferase activity [Evidence IDA,IMP,ISS] [PMID 8982874]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IMP] [PMID 8982874]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00698
Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor; GO_component: GO:0045009 - chitosome [Evidence IDA] [PMID 8970154]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8970154]; GO_function: GO:0004100 - chitin synthase activity [Evidence IEA,IEA]; GO_function: GO:0004100 - chitin synthase activity [Evidence IDA] [PMID 7952171]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0006031 - chitin biosynthetic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 2523889]
similar to AA sequence:KEGG_Orthology:K14567
Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA,IPI] [PMID 9343412]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IDA] [PMID 9343412]; GO_process: GO:0042149 - cellular response to glucose starvation [Evidence IMP] [PMID 9343412]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 9343412]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9343412]; GO_process: GO:0071472 - cellular response to salt stress [Evidence IMP] [PMID 9343412]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
mitochondrial 37S ribosomal protein RSM10
similar to AA sequence:KEGG_Orthology:K02946
Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins; GO_component: GO:0005763 - mitochondrial small ribosomal subunit [Evidence IPI] [PMID 11278769]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 11278769]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 11278769]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18849
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23558746]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IMP] [PMID 23558746]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15015
Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11274162]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IMP] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015186 - L-glutamine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0015188 - L-isoleucine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005302 - L-tyrosine transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IMP] [PMID 11274162]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 11274162]
similar to AA sequence:KEGG_Orthology:K03510
similar to AA sequence:KEGG_Orthology:K07897
Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11853670]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22593205]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0030906 - retromer complex, inner shell [Evidence IPI] [PMID 22593205]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence TAS] [PMID 9714809]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 1473149]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0072665 - protein localization to vacuole [Evidence IMP] [PMID 22593205]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 7489715]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 22593205]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0000011 - vacuole inheritance [Evidence IDA] [PMID 7489715]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IDA] [PMID 9015302]
similar to AA sequence:KEGG_Orthology:K01895
Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16857587]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9711835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 19618123]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16857587]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19618123]; GO_function: GO:0016208 - AMP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IEA,IEA]; GO_function: GO:0003987 - acetate-CoA ligase activity [Evidence IDA] [PMID 8910545]; GO_function: GO:0016880 - acid-ammonia (or amide) ligase activity [Evidence IDA] [PMID 18305111]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006085 - acetyl-CoA biosynthetic process [Evidence IDA] [PMID 8910545]; GO_process: GO:0019427 - acetyl-CoA biosynthetic process from acetate [Evidence IEA]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 16857587]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 19618123]
Usp (universal stress protein) family protein
similar to AA sequence:KEGG_Orthology:K10849
Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; GO_component: GO:0000110 - nucleotide-excision repair factor 1 complex [Evidence IPI] [PMID 8621533]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852079]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 1741062]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence IDA] [PMID 8253764]; GO_process: GO:0006277 - DNA amplification [Evidence IMP] [PMID 23271978]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0000733 - DNA strand renaturation [Evidence IDA] [PMID 1741062]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000736 - double-strand break repair via single-strand annealing, removal of nonhomologous ends [Evidence IMP] [PMID 7891718]; GO_process: GO:0000710 - meiotic mismatch repair [Evidence IMP] [PMID 11514439]; GO_process: GO:0006312 - mitotic recombination [Evidence IMP] [PMID 2188090]; GO_process: GO:0006296 - nucleotide-excision repair, DNA incision, 5'-to lesion [Evidence IDA] [PMID 7559571]; GO_process: GO:0000735 - removal of nonhomologous ends [Evidence IMP] [PMID 7891718]
similar to AA sequence:KEGG_Orthology:K07560
D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0097358 - D-leucyl-tRNA(Leu) deacylase activity [Evidence IMP] [PMID 10918062]; GO_function: GO:0051500 - D-tyrosyl-tRNA(Tyr) deacylase activity [Evidence IMP] [PMID 10766779]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_process: GO:0019478 - D-amino acid catabolic process [Evidence IEA]; GO_process: GO:1900832 - D-leucine catabolic process [Evidence IMP] [PMID 10918062]; GO_process: GO:1900829 - D-tyrosine catabolic process [Evidence IMP] [PMID 10918062]; GO_process: GO:0006399 - tRNA metabolic process [Evidence IMP] [PMID 10918062]
similar to AA sequence:KEGG_Orthology:K12762
Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10655215]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9388468]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9524122]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IEA]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IPI] [PMID 9388468]; GO_function: GO:0004930 - G-protein coupled receptor activity [Evidence IMP,IPI,ISS] [PMID 9524122]; GO_function: GO:0005536 - glucose binding [Evidence IMP] [PMID 15494315]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IPI] [PMID 9388468]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 9524122]; GO_process: GO:0051594 - detection of glucose [Evidence IMP] [PMID 15494315]; GO_process: GO:0009731 - detection of sucrose stimulus [Evidence IMP] [PMID 15494315]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IGI,IMP] [PMID 10361302]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP] [PMID 15494315]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP] [PMID 9813141]; GO_process: GO:0009757 - hexose mediated signaling [Evidence IMP] [PMID 10655215]; GO_process: GO:0009757 - hexose mediated signaling [Evidence IGI,IMP] [PMID 9813141]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12150916]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 10655215]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0009745 - sucrose mediated signaling [Evidence IMP] [PMID 15494315]
Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISM] [PMID 19351663]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 21460220]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IDA] [PMID 21460220]
similar to AA sequence:KEGG_Orthology:K00133
Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003942 - N-acetyl-gamma-glutamyl-phosphate reductase activity [Evidence IEA]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0004073 - aspartate-semialdehyde dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0004073 - aspartate-semialdehyde dehydrogenase activity [Evidence IDA] [PMID 4145650]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0046983 - protein dimerization activity [Evidence IEA]; GO_process: GO:0006531 - aspartate metabolic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]; GO_process: GO:0009090 - homoserine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0009085 - lysine biosynthetic process [Evidence IEA]; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IMP] [PMID 4380684]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009088 - threonine biosynthetic process [Evidence IMP] [PMID 4380684]
Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate; GO_component: GO:0034967 - Set3 complex [Evidence IDA] [PMID 11711434]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0016575 - histone deacetylation [Evidence IDA] [PMID 11711434]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IPI] [PMID 11711434]
similar to AA sequence:KEGG_Orthology:K19029
Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IKR] [PMID 9032445]; GO_function: GO:0003873 - 6-phosphofructo-2-kinase activity [Evidence IKR] [PMID 9032446]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IEA,IEA]; GO_function: GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity [Evidence IMP] [PMID 1322693]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0006003 - fructose 2,6-bisphosphate metabolic process [Evidence IEA]; GO_process: GO:0006000 - fructose metabolic process [Evidence IEA]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 1322693]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03657
glucose-inactivated glycerol proton symporter STL1
serine/threonine/tyrosine protein kinase MPS1
similar to AA sequence:KEGG_Orthology:K08866
similar to AA sequence:KEGG_Orthology:K07827
GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 22575457]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22575457]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23127800]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11914276]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 20162532]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23127800]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IDA] [PMID 6438624]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8106517]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007190 - activation of adenylate cyclase activity [Evidence IDA] [PMID 8106517]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 2558958]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 2981630]; GO_process: GO:0045762 - positive regulation of adenylate cyclase activity [Evidence IGI] [PMID 3891097]; GO_process: GO:0000411 - positive regulation of transcription by galactose [Evidence IMP] [PMID 16292676]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 12782684]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 1547504]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 15917658]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12839995]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 8034612]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9046086]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015893 - drug transport [Evidence IEP] [PMID 12697649]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09578
Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10531363]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10899126]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 10899127]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 11708797]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 14704159]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 10531363]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 10899126]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA,IMP] [PMID 15728580]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9867817]; GO_process: GO:0080182 - histone H3-K4 trimethylation [Evidence IGI,IMP] [PMID 22778132]; GO_process: GO:0031064 - negative regulation of histone deacetylation [Evidence IMP,IPI] [PMID 10899127]; GO_process: GO:2000059 - negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 19597489]; GO_process: GO:0000122 - negative regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 14704159]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IGI] [PMID 15166139]; GO_process: GO:2000749 - positive regulation of chromatin silencing at rDNA [Evidence IMP] [PMID 10899127]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IDA] [PMID 11904169]; GO_process: GO:0035307 - positive regulation of protein dephosphorylation [Evidence IMP] [PMID 19854134]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IPI] [PMID 10899126]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IDA,IMP] [PMID 15728580]; GO_process: GO:1901407 - regulation of phosphorylation of RNA polymerase II C-terminal domain [Evidence IDA] [PMID 22778132]; GO_process: GO:0000083 - regulation of transcription involved in G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 11708797]; GO_process: GO:0000117 - regulation of transcription involved in G2/M transition of mitotic cell cycle [Evidence IMP] [PMID 11708797]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 14704159]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IGI,IMP] [PMID 19854134]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IMP] [PMID 22778132]
similar to AA sequence:KEGG_Orthology:K13099
similar to AA sequence:KEGG_Orthology:K05019
similar to AA sequence:KEGG_Orthology:K04348
Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication; GO_component: GO:0005955 - calcineurin complex [Evidence IPI] [PMID 10887154]; GO_component: GO:0005955 - calcineurin complex [Evidence IDA] [PMID 1321337]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity [Evidence IDA] [PMID 1321337]; GO_function: GO:0005516 - calmodulin binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA,IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 1651503]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 8798496]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14800
Protein with a potential role in pre-rRNA processing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01452
Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall; GO_component: GO:0005631 - chitosan layer of spore wall [Evidence ISS] [PMID 8940152]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IEA]; GO_function: GO:0004099 - chitin deacetylase activity [Evidence IDA,ISS] [PMID 8940152]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA,IMP] [PMID 8940152]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0006032 - chitin catabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
Ubiquinone/menaquinone biosynthesis methyltransferase ubiE
similar to AA sequence:KEGG_Orthology:K13621
Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0012510 - trans-Golgi network transport vesicle membrane [Evidence IDA] [PMID 9325307]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IDA] [PMID 15078884]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IMP] [PMID 7708696]; GO_function: GO:0005507 - copper ion binding [Evidence IEA]; GO_function: GO:0005507 - copper ion binding [Evidence IDA] [PMID 17961510]; GO_function: GO:0043682 - copper-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 7708696]; GO_process: GO:0060003 - copper ion export [Evidence IMP] [PMID 7708696]; GO_process: GO:0006825 - copper ion transport [Evidence IEA,IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0030001 - metal ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7708696]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01834
Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 3332961]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016868 - intramolecular transferase activity, phosphotransferases [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IEA]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IDA] [PMID 1386023]; GO_function: GO:0004619 - phosphoglycerate mutase activity [Evidence IMP] [PMID 3033435]; GO_process: GO:0006094 - gluconeogenesis [Evidence IMP] [PMID 3033435]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IMP] [PMID 11015729]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates unfolded protein response (UPR) by promoting the decay of HAC1 RNA; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0005795 - Golgi stack [Evidence IDA] [PMID 12802060]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IDA] [PMID 23129774]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 10747087]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 20375281]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 20059749]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 3311726]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 9447979]; GO_function: GO:0000149 - SNARE binding [Evidence IDA,IPI] [PMID 18388317]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 15689495]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20375281]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 15689495]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 2504726]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 7593181]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IGI] [PMID 18388317]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IMP] [PMID 9545229]; GO_process: GO:0035494 - SNARE complex disassembly [Evidence IMP] [PMID 9157884]; GO_process: GO:0034498 - early endosome to Golgi transport [Evidence IMP] [PMID 20059749]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 20059749]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20375281]; GO_process: GO:1990261 - pre-mRNA catabolic process [Evidence IMP] [PMID 22844259]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 8603910]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:1900101 - regulation of endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 22844259]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IGI,IMP] [PMID 18388317]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14844
Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0015934 - large ribosomal subunit [Evidence IDA] [PMID 19806183]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003730 - mRNA 3'-UTR binding [Evidence IDA] [PMID 15198983]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000900 - translation repressor activity, nucleic acid binding [Evidence IDA] [PMID 15198983]; GO_process: GO:0017148 - negative regulation of translation [Evidence IDA] [PMID 15198983]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006810 - transport [Evidence IEA]
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding; GO_component: GO:0016602 - CCAAT-binding factor complex [Evidence IDA,IPI] [PMID 2832951]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 7828851]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 2832951]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IDA] [PMID 2832951]; GO_process: GO:0043457 - regulation of cellular respiration [Evidence IMP] [PMID 2182199]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03247
similar to AA sequence:KEGG_Orthology:K12817
Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p; GO_component: GO:0071021 - U2-type post-spliceosomal complex [Evidence IDA] [PMID 12212850]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 8474454]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 8474454]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA,IEA]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IDA] [PMID 12212850]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IGI] [PMID 17626844]; GO_process: GO:0008380 - RNA splicing [Evidence IEA,IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IDA] [PMID 12212850]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12403466]; GO_process: GO:0071048 - nuclear retention of unspliced pre-mRNA at the site of transcription [Evidence IGI,IMP] [PMID 14718167]
similar to AA sequence:KEGG_Orthology:K12795
Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IDA] [PMID 10445024]; GO_function: GO:0051087 - chaperone binding [Evidence ISS] [PMID 12456005]; GO_function: GO:0051087 - chaperone binding [Evidence IDA] [PMID 16945921]; GO_function: GO:0030674 - protein binding, bridging [Evidence IDA] [PMID 16945921]; GO_process: GO:0019933 - cAMP-mediated signaling [Evidence IGI,IPI] [PMID 12456005]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051382 - kinetochore assembly [Evidence IDA] [PMID 10445024]; GO_process: GO:0006461 - protein complex assembly [Evidence IGI,ISS] [PMID 12456005]; GO_process: GO:0006461 - protein complex assembly [Evidence IDA] [PMID 15090617]; GO_process: GO:0016567 - protein ubiquitination [Evidence TAS] [PMID 12456005]; GO_process: GO:0051726 - regulation of cell cycle [Evidence TAS] [PMID 11847307]
similar to AA sequence:KEGG_Orthology:K11883
Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12588997]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12502737]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12588997]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 12588997]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19801658]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0070181 - small ribosomal subunit rRNA binding [Evidence IDA] [PMID 19706509]; GO_process: GO:0030490 - maturation of SSU-rRNA [Evidence IDA] [PMID 19801658]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEP,IMP] [PMID 12588997]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15388878]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0043248 - proteasome assembly [Evidence IMP,IPI] [PMID 12502737]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IDA] [PMID 12588997]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IPI] [PMID 12628929]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07836
GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15282802]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8723349]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 1910037]; GO_function: GO:0003924 - GTPase activity [Evidence TAS] [PMID 9759491]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence TAS] [PMID 9891811]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence TAS] [PMID 2065354]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence TAS] [PMID 2690082]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 2065354]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence TAS] [PMID 2690082]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence TAS] [PMID 9759491]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence TAS] [PMID 9891811]
methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor
similar to AA sequence:KEGG_Orthology:K01969
isovaleryl-CoA dehydrogenase, mitochondrial precursor
similar to AA sequence:KEGG_Orthology:K00253
oxysterol-binding protein related protein OSH2
Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH2 has a paralog, SWH1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11408574]; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12727870]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11408574]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0015918 - sterol transport [Evidence IGI] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA] [PMID 20008566]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03320
Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence TAS] [PMID 11486013]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 9234685]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IEA]; GO_function: GO:0008519 - ammonium transmembrane transporter activity [Evidence IDA,IMP,ISS] [PMID 9234685]; GO_process: GO:0072488 - ammonium transmembrane transport [Evidence IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IEA,IEA]; GO_process: GO:0015696 - ammonium transport [Evidence IMP,ISS] [PMID 9234685]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 9234685]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12176
similar to AA sequence:KEGG_Orthology:K01869
Mitochondrial leucyl-tRNA synthetase; also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 1990003]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004823 - leucine-tRNA ligase activity [Evidence IDA] [PMID 1990003]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IPI] [PMID 11142386]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 12486008]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 2277640]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006429 - leucyl-tRNA aminoacylation [Evidence IDA] [PMID 1990003]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12041
Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; GO_component: GO:0005769 - early endosome [Evidence IDA] [PMID 22210050]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20826459]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 20709757]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 22210050]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 9694857]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 22210050]; GO_function: GO:0015297 - antiporter activity [Evidence IEA]; GO_function: GO:0015386 - potassium:proton antiporter activity [Evidence IMP] [PMID 15635088]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IEA]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 10998367]; GO_function: GO:0015385 - sodium:proton antiporter activity [Evidence IMP] [PMID 15635088]; GO_function: GO:0015299 - solute:proton antiporter activity [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0030004 - cellular monovalent inorganic cation homeostasis [Evidence IMP] [PMID 10589731]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0071805 - potassium ion transmembrane transport [Evidence IMP] [PMID 15635088]; GO_process: GO:0006813 - potassium ion transport [Evidence IEA]; GO_process: GO:0006885 - regulation of pH [Evidence IEA]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IMP] [PMID 10998367]; GO_process: GO:0035725 - sodium ion transmembrane transport [Evidence IMP] [PMID 15635088]; GO_process: GO:0006814 - sodium ion transport [Evidence IEA,IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence IMP] [PMID 10589731]
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IEA]; GO_component: GO:0030915 - Smc5-Smc6 complex [Evidence IDA] [PMID 15738391]; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11927594]; GO_component: GO:0035861 - site of double-strand break [Evidence IDA] [PMID 16892052]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0019789 - SUMO ligase activity [Evidence IDA] [PMID 15738391]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 16793545]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 11927594]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15738391]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0051304 - chromosome separation [Evidence IMP] [PMID 15793567]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IEA]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16892052]; GO_process: GO:0071139 - resolution of recombination intermediates [Evidence IMP] [PMID 20159973]
Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA,IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 17192843]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8603910]; GO_process: GO:0048211 - Golgi vesicle docking [Evidence IDA] [PMID 9545229]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IEA]; GO_process: GO:0035493 - SNARE complex assembly [Evidence IMP] [PMID 8603910]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14772
Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 17652137]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17652137]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15590835]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 17652137]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 17652137]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 17652137]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15590835]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 17652137]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01937
Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication; GO_component: GO:0097268 - cytoophidium [Evidence IDA] [PMID 20713603]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003883 - CTP synthase activity [Evidence IEA,IEA]; GO_function: GO:0003883 - CTP synthase activity [Evidence IMP,ISS] [PMID 1753946]; GO_function: GO:0003883 - CTP synthase activity [Evidence IDA] [PMID 8075080]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0044210 - 'de novo' CTP biosynthetic process [Evidence IEA]; GO_process: GO:0006241 - CTP biosynthetic process [Evidence IDA] [PMID 8075080]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 9668079]; GO_process: GO:0019856 - pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 1753946]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA,IEA]
trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1
similar to AA sequence:KEGG_Orthology:K18097
NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004032 - alditol:NADP+ 1-oxidoreductase activity [Evidence IDA,ISS] [PMID 11306085]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence IDA] [PMID 19016485]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0042843 - D-xylose catabolic process [Evidence IDA] [PMID 12271459]; GO_process: GO:0019568 - arabinose catabolic process [Evidence IDA,IMP] [PMID 12271459]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17919749]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Cytoplasmic protein required for sporulation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
SCF ubiquitin ligase complex subunit CDC4
similar to AA sequence:KEGG_Orthology:K03361
F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346238]; GO_component: GO:0019005 - SCF ubiquitin ligase complex [Evidence IDA,IPI] [PMID 9346239]; GO_component: GO:0043224 - nuclear SCF ubiquitin ligase complex [Evidence IDA] [PMID 11080155]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 2244914]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11080155]; GO_function: GO:0050815 - phosphoserine binding [Evidence IDA] [PMID 23314252]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_function: GO:0061630 - ubiquitin protein ligase activity [Evidence IDA] [PMID 9346238]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 9346239]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10409741]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI] [PMID 7954792]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 328339]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346238]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 9346239]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11205
similar to AA sequence:KEGG_Orthology:K06890
Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 21673967]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 21673659]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 21673967]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 21673659]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006915 - apoptotic process [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 21673659]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 21673967]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 21673967]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 21673967]
similar to AA sequence:KEGG_Orthology:K01078
similar to AA sequence:KEGG_Orthology:K13076
Peptide-N4-(N-acetyl-beta- glucosaminyl)asparagineamidase A
similar to AA sequence:KEGG_Orthology:K01591
Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18812321]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IEA,IEA]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IDA] [PMID 2061334]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004590 - orotidine-5'-phosphate decarboxylase activity [Evidence IMP] [PMID 5651325]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 5651325]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IDA] [PMID 2061334]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0006222 - UMP biosynthetic process [Evidence IMP] [PMID 5651325]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14811
RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9032262]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 22083961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 18975973]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence IDA] [PMID 23153376]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9032262]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9659914]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016671 - oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IEA]; GO_function: GO:0003756 - protein disulfide isomerase activity [Evidence IMP] [PMID 10982384]; GO_function: GO:0016972 - thiol oxidase activity [Evidence IDA] [PMID 16407158]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IGI] [PMID 11584268]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 9659913]
Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores; GO_component: GO:0005619 - ascospore wall [Evidence IDA] [PMID 19779569]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 19779569]; GO_component: GO:0031160 - spore wall [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042802 - identical protein binding [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IBA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence ISS] [PMID 10592175]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IMP] [PMID 19779569]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IBA,IEA,IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17605
Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15150670]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 21129186]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15150670]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16380387]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IMP] [PMID 12952889]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15150670]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 9705277]; GO_process: GO:0000082 - G1/S transition of mitotic cell cycle [Evidence IPI] [PMID 11134337]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 11262194]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]; GO_process: GO:0043618 - regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IMP,IPI] [PMID 21129186]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 10660069]
similar to AA sequence:KEGG_Orthology:K14310
Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0044615 - nuclear pore nuclear basket [Evidence IDA] [PMID 10428845]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 10428845]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006999 - nuclear pore organization [Evidence IMP] [PMID 10428845]; GO_process: GO:0006999 - nuclear pore organization [Evidence IMP] [PMID 11121302]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14306
similar to AA sequence:KEGG_Orthology:K00281
P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm; GO_component: GO:0005960 - glycine cleavage complex [Evidence ISS] [PMID 8830251]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IEA,IEA]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IDA] [PMID 320197]; GO_function: GO:0004375 - glycine dehydrogenase (decarboxylating) activity [Evidence IDA] [PMID 8830251]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_process: GO:0006546 - glycine catabolic process [Evidence IEA]; GO_process: GO:0019464 - glycine decarboxylation via glycine cleavage system [Evidence IEP,IMP] [PMID 8830251]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 10871621]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14864
2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11927565]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IDA] [PMID 11927565]; GO_function: GO:0008175 - tRNA methyltransferase activity [Evidence IMP,ISS] [PMID 9917067]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 11927565]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 11927565]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K04567
Lysyl-tRNA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 330225]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IDA] [PMID 3888626]; GO_function: GO:0004824 - lysine-tRNA ligase activity [Evidence IMP] [PMID 7628447]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IDA] [PMID 3888626]; GO_process: GO:0006430 - lysyl-tRNA aminoacylation [Evidence IMP] [PMID 7628447]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03139
TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IEA]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 12242279]; GO_component: GO:0005674 - transcription factor TFIIF complex [Evidence IDA] [PMID 7995524]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000991 - core RNA polymerase II binding transcription factor activity [Evidence IDA] [PMID 14749386]; GO_function: GO:0001139 - core RNA polymerase II recruiting transcription factor activity [Evidence IC] [PMID 7995524]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0051123 - RNA polymerase II transcriptional preinitiation complex assembly [Evidence IC] [PMID 7995524]; GO_process: GO:0001111 - promoter clearance from RNA polymerase II promoter [Evidence IC] [PMID 7995524]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 18362165]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 18362165]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 15572698]; GO_process: GO:0001174 - transcriptional start site selection at RNA polymerase II promoter [Evidence IMP] [PMID 20033062]
similar to AA sequence:KEGG_Orthology:K08857
similar to AA sequence:KEGG_Orthology:K11400
Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 3967297]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 6365930]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 8163554]; GO_component: GO:0005884 - actin filament [Evidence IDA] [PMID 6217414]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 3967297]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 6365930]; GO_component: GO:0032432 - actin filament bundle [Evidence IDA] [PMID 8163554]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 3967297]; GO_component: GO:0000142 - cellular bud neck contractile ring [Evidence IDA] [PMID 8163554]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 10911987]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IDA] [PMID 6217414]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0000916 - actomyosin contractile ring contraction [Evidence IDA,IMP] [PMID 9732290]; GO_process: GO:0030476 - ascospore wall assembly [Evidence IDA] [PMID 17118118]; GO_process: GO:0007119 - budding cell isotropic bud growth [Evidence TAS] [PMID 10652251]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI] [PMID 17287397]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 15024029]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 8590801]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IGI] [PMID 9864365]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence TAS] [PMID 10652251]; GO_process: GO:0006887 - exocytosis [Evidence TAS] [PMID 10652251]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence TAS] [PMID 10652251]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10911987]; GO_process: GO:0000001 - mitochondrion inheritance [Evidence TAS] [PMID 10652251]; GO_process: GO:0009306 - protein secretion [Evidence IGI,IMP] [PMID 10793147]; GO_process: GO:0000011 - vacuole inheritance [Evidence IGI,IMP] [PMID 8978821]; GO_process: GO:0030050 - vesicle transport along actin filament [Evidence TAS] [PMID 10652251]
similar to AA sequence:KEGG_Orthology:K03253
eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 9722586]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IDA] [PMID 17242201]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9660829]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IDA,IPI] [PMID 9671501]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 11018020]; GO_component: GO:0043614 - multi-eIF complex [Evidence IDA] [PMID 15838098]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA,IPI,ISS] [PMID 7876188]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IDA] [PMID 9671501]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IEA]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA,IEA]; GO_process: GO:0006413 - translational initiation [Evidence IMP] [PMID 3029094]; GO_process: GO:0006413 - translational initiation [Evidence IDA] [PMID 9671501]
similar to AA sequence:KEGG_Orthology:K00088
Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003938 - IMP dehydrogenase activity [Evidence ISS] [PMID 11003640]; GO_function: GO:0030554 - adenyl nucleotide binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006177 - GMP biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01381
Mitochondrial intermembrane space hypothetical protein; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 11791739]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22984289]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 22993211]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11791739]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9874242]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K16833
Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 12127071]; GO_function: GO:0004864 - protein phosphatase inhibitor activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 7565759]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence TAS] [PMID 9584086]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IEA]; GO_process: GO:0043086 - negative regulation of catalytic activity [Evidence IEA]; GO_process: GO:0043666 - regulation of phosphoprotein phosphatase activity [Evidence IEA]; GO_process: GO:0009966 - regulation of signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07375
Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005881 - cytoplasmic microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0005828 - kinetochore microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0005874 - microtubule [Evidence IEA,IEA]; GO_component: GO:0005880 - nuclear microtubule [Evidence IC] [PMID 9488492]; GO_component: GO:0043234 - protein complex [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9585415]; GO_component: GO:0045298 - tubulin complex [Evidence IDA,IPI] [PMID 9488492]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0045143 - homologous chromosome segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0007017 - microtubule-based process [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IC] [PMID 9488492]; GO_process: GO:0030473 - nuclear migration along microtubule [Evidence IC] [PMID 9488492]; GO_process: GO:0051258 - protein polymerization [Evidence IEA]; GO_process: GO:0046677 - response to antibiotic [Evidence IEA]
Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8866476]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 11390404]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015093 - ferrous iron transmembrane transporter activity [Evidence IMP] [PMID 11390404]; GO_function: GO:0005384 - manganese ion transmembrane transporter activity [Evidence IMP] [PMID 11390404]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI,IMP] [PMID 7941738]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 10713071]; GO_process: GO:0030026 - cellular manganese ion homeostasis [Evidence IGI,IMP] [PMID 8866476]; GO_process: GO:0015684 - ferrous iron transport [Evidence IMP] [PMID 11390404]; GO_process: GO:0006828 - manganese ion transport [Evidence IMP] [PMID 11390404]; GO_process: GO:0006810 - transport [Evidence IEA]
High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 8893857]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_function: GO:0000102 - L-methionine secondary active transmembrane transporter activity [Evidence IDA] [PMID 8893857]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0042883 - cysteine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0044690 - methionine import [Evidence IGI,IMP] [PMID 8893857]; GO_process: GO:0015821 - methionine transport [Evidence IDA] [PMID 11330701]; GO_process: GO:0000101 - sulfur amino acid transport [Evidence IMP] [PMID 8893857]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05692
similar to AA sequence:KEGG_Orthology:K01537
Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 7507493]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 10431803]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IGI] [PMID 7507493]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 15280017]; GO_process: GO:0006816 - calcium ion transport [Evidence IMP] [PMID 7507493]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IMP] [PMID 7507493]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 7507493]; GO_process: GO:0006810 - transport [Evidence IEA]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; YPS1 has a paralog, MKC7, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA] [PMID 8389368]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0016485 - protein processing [Evidence IDA] [PMID 8626758]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
Putative dihydrokaempferol 4-reductase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004090 - carbonyl reductase (NADPH) activity [Evidence ISA] [PMID 19577617]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08343
E2-like enzyme; involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11149920]; GO_function: GO:0019776 - Atg8 ligase activity [Evidence IMP,ISS] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IMP] [PMID 11100732]; GO_process: GO:0006501 - C-terminal protein lipidation [Evidence IDA,IMP] [PMID 15277523]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 9023185]; GO_process: GO:0000045 - autophagic vacuole assembly [Evidence IMP] [PMID 11149920]; GO_process: GO:0006914 - autophagy [Evidence IEA]; GO_process: GO:0044805 - late nucleophagy [Evidence IMP] [PMID 22768199]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 19793921]; GO_process: GO:0034727 - piecemeal microautophagy of nucleus [Evidence IMP] [PMID 18701704]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11267
Protein involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000794 - condensed nuclear chromosome [Evidence IDA] [PMID 11062262]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000798 - nuclear cohesin complex [Evidence IDA] [PMID 22901742]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 22912589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005198 - structural molecule activity [Evidence ISS] [PMID 11137006]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 19736318]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 15819623]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IMP] [PMID 11062262]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 11062262]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 14623866]; GO_process: GO:0007129 - synapsis [Evidence IMP] [PMID 19736318]
Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286007]; GO_component: GO:0032221 - Rpd3S complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0000118 - histone deacetylase complex [Evidence IDA] [PMID 16286008]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16286007]; GO_process: GO:0060195 - negative regulation of antisense RNA transcription [Evidence IMP] [PMID 21248844]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 19417103]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IGI] [PMID 19948887]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0061587 - transfer RNA gene-mediated silencing [Evidence IMP] [PMID 23707796]
Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IGI,ISA] [PMID 8618900]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00620
Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 205532]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity [Evidence IDA,IGI] [PMID 9428669]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004358 - glutamate N-acetyltransferase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0004358 - glutamate N-acetyltransferase activity [Evidence IDA] [PMID 9428669]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA,IEA,IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence TAS] [PMID 12603335]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006592 - ornithine biosynthetic process [Evidence IDA] [PMID 9428669]
similar to AA sequence:KEGG_Orthology:K15029
similar to AA sequence:KEGG_Orthology:K12845
RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IMP,ISS] [PMID 14730029]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17332014]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 17631273]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 14730029]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14730029]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01268
Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 1400574]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 3882418]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2651436]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence ISS] [PMID 2689224]
Putative paralog of ATR1; but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0015124 - allantoate transmembrane transporter activity [Evidence IMP,ISS] [PMID 3275614]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IMP] [PMID 16429164]; GO_function: GO:0042936 - dipeptide transporter activity [Evidence IGI,IMP] [PMID 17693598]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015719 - allantoate transport [Evidence IMP] [PMID 3275614]; GO_process: GO:0042938 - dipeptide transport [Evidence IMP] [PMID 16429164]; GO_process: GO:0042938 - dipeptide transport [Evidence IGI,IMP] [PMID 17693598]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042939 - tripeptide transport [Evidence IMP] [PMID 16429164]
similar to AA sequence:KEGG_Orthology:K12617
Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23706738]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA,IMP] [PMID 12730603]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 23222640]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 10779343]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23706738]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 23706738]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IDA] [PMID 23222640]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0033962 - cytoplasmic mRNA processing body assembly [Evidence IGI,IMP] [PMID 18981231]; GO_process: GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA [Evidence IMP,IPI] [PMID 10913177]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IMP] [PMID 20832728]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0045947 - negative regulation of translational initiation [Evidence IDA,IMP] [PMID 20832728]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IGI,IMP] [PMID 10779343]
similar to AA sequence:KEGG_Orthology:K03955
Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0000036 - ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [Evidence ISS] [PMID 8394042]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0009107 - lipoate biosynthetic process [Evidence IMP] [PMID 9187370]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 8841414]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IDA] [PMID 8841414]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 20844764]; GO_function: GO:0050203 - oxalate-CoA ligase activity [Evidence IDA,IMP] [PMID 24291261]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0033611 - oxalate catabolic process [Evidence IDA,IMP] [PMID 24291261]
similar to AA sequence:KEGG_Orthology:K14807
Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9528757]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 15126390]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17145778]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence ISS] [PMID 10322435]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9528757]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9528757]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
1-phosphatidylinositol-4-phosphate 5-kinase
similar to AA sequence:KEGG_Orthology:K00889
Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9624177]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IEA]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624177]; GO_function: GO:0016308 - 1-phosphatidylinositol-4-phosphate 5-kinase activity [Evidence IDA] [PMID 9624178]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016307 - phosphatidylinositol phosphate kinase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031321 - ascospore-type prospore assembly [Evidence IGI] [PMID 19502581]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624177]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 9624178]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
polyprotein of L1-like non-LTR retrotransposon Zorro 1
polyprotein of non-LTR retrotransposon Zorro 1 and repeat region-related DNA
similar to AA sequence:KEGG_Orthology:K14304
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8565072]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8816998]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8565072]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8816998]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA] [PMID 15817685]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 11071906]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13118
NuA4 histone acetyltransferase complex catalytic subunit ESA1
similar to AA sequence:KEGG_Orthology:K11304
Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 10487762]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 10911987]; GO_component: GO:0035267 - NuA4 histone acetyltransferase complex [Evidence IPI] [PMID 15485911]; GO_component: GO:0032777 - Piccolo NuA4 histone acetyltransferase complex [Evidence IDA] [PMID 12782659]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 10911987]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence IDA] [PMID 10911987]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0010485 - H4 histone acetyltransferase activity [Evidence IDA] [PMID 12110674]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IEA]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 10487762]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA] [PMID 17274630]; GO_function: GO:0034212 - peptide N-acetyltransferase activity [Evidence IMP] [PMID 23050233]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 12353039]; GO_process: GO:0006281 - DNA repair [Evidence IDA] [PMID 16135807]; GO_process: GO:0006354 - DNA-templated transcription, elongation [Evidence IDA,IMP] [PMID 15949446]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IGI,IMP] [PMID 16436512]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10082517]; GO_process: GO:0016573 - histone acetylation [Evidence IDA] [PMID 10487762]; GO_process: GO:0018394 - peptidyl-lysine acetylation [Evidence IMP] [PMID 23050233]; GO_process: GO:0016239 - positive regulation of macroautophagy [Evidence IMP] [PMID 22539722]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IGI,IMP] [PMID 19822662]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 10082517]; GO_process: GO:0034401 - regulation of transcription by chromatin organization [Evidence IMP] [PMID 11867538]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11036083]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0000159 - protein phosphatase type 2A complex [Evidence IDA] [PMID 17550305]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 16380387]; GO_function: GO:0019211 - phosphatase activator activity [Evidence IEA]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IGI,ISS] [PMID 10660069]; GO_function: GO:0008601 - protein phosphatase type 2A regulator activity [Evidence IMP] [PMID 12952889]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IMP] [PMID 11262194]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA]; GO_process: GO:0006970 - response to osmotic stress [Evidence IGI,IMP] [PMID 10660069]
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13
similar to AA sequence:KEGG_Orthology:K07432
Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; GO_component: GO:0043541 - UDP-N-acetylglucosamine transferase complex [Evidence IPI] [PMID 16100110]; GO_component: GO:0043541 - UDP-N-acetylglucosamine transferase complex [Evidence IPI] [PMID 16100113]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16100110]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16100113]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0042406 - extrinsic component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16100110]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IEA]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IMP,ISS] [PMID 15615718]; GO_function: GO:0004577 - N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [Evidence IDA,IMP,ISS] [PMID 16100113]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_function: GO:0016758 - transferase activity, transferring hexosyl groups [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IMP,ISS] [PMID 15615718]; GO_process: GO:0006488 - dolichol-linked oligosaccharide biosynthetic process [Evidence IDA,IMP,ISS] [PMID 16100113]; GO_process: GO:0030259 - lipid glycosylation [Evidence IEA]
Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 10805735]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005506 - iron ion binding [Evidence IDA] [PMID 21987576]; GO_process: GO:0009102 - biotin biosynthetic process [Evidence IGI,IMP] [PMID 17259550]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IGI,IMP] [PMID 10805735]
similar to AA sequence:KEGG_Orthology:K01077
bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
similar to AA sequence:KEGG_Orthology:K00838
Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IEA]; GO_function: GO:0047536 - 2-aminoadipate transaminase activity [Evidence IDA] [PMID 19342587]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0008793 - aromatic-amino-acid:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 9491082]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IEA]; GO_process: GO:0009072 - aromatic amino acid family metabolic process [Evidence IGI,IMP] [PMID 9491083]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0019878 - lysine biosynthetic process via aminoadipic acid [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07952
ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077113]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15077114]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0042175 - nuclear outer membrane-endoplasmic reticulum membrane network [Evidence IDA] [PMID 9920936]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 9920936]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 16926193]; GO_process: GO:0006886 - intracellular protein transport [Evidence IMP] [PMID 9920936]; GO_process: GO:0033365 - protein localization to organelle [Evidence IMP] [PMID 12620189]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
phosphoribosylaminoimidazolesuccinocarboxamide synthase
similar to AA sequence:KEGG_Orthology:K01923
N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IEA,IEA]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IDA] [PMID 1756975]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IMP] [PMID 5767024]; GO_function: GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [Evidence IMP] [PMID 5767025]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IEA]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IDA] [PMID 1756975]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5767024]; GO_process: GO:0006189 - 'de novo' IMP biosynthetic process [Evidence IMP] [PMID 5767025]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IDA] [PMID 1756975]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5767024]; GO_process: GO:0006164 - purine nucleotide biosynthetic process [Evidence IMP] [PMID 5767025]
similar to AA sequence:KEGG_Orthology:K19708
Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 17166847]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 18180296]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0004741 - [pyruvate dehydrogenase (lipoamide)] phosphatase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IEA]; GO_function: GO:0004722 - protein serine/threonine phosphatase activity [Evidence IDA] [PMID 17002782]; GO_process: GO:0016236 - macroautophagy [Evidence IGI] [PMID 17166847]; GO_process: GO:0000422 - mitochondrion degradation [Evidence IMP] [PMID 17166847]; GO_process: GO:0043085 - positive regulation of catalytic activity [Evidence IMP] [PMID 18180296]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IMP] [PMID 18180296]
similar to AA sequence:KEGG_Orthology:K00106
Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 24868093]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 18034159]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 18034159]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0034084 - steryl deacetylase activity [Evidence IDA,IMP] [PMID 18034159]; GO_process: GO:0009636 - response to toxic substance [Evidence IMP] [PMID 18034159]; GO_process: GO:0034210 - sterol deacetylation [Evidence IMP] [PMID 18034159]; GO_process: GO:0016125 - sterol metabolic process [Evidence IMP] [PMID 18034159]
similar to AA sequence:KEGG_Orthology:K00459
putative N,N-dimethylaniline monooxygenase COQ6
similar to AA sequence:KEGG_Orthology:K06126
Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS); GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12721307]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004499 - N,N-dimethylaniline monooxygenase activity [Evidence ISA] [PMID 12721307]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016709 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 21944752]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9266513]
similar to AA sequence:KEGG_Orthology:K12735
similar to AA sequence:KEGG_Orthology:K01046
Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19959834]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IMP] [PMID 9544243]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IMP] [PMID 19959834]
similar to AA sequence:KEGG_Orthology:K00128
Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IDA] [PMID 9473035]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0019413 - acetate biosynthetic process [Evidence IMP] [PMID 15256563]; GO_process: GO:0006068 - ethanol catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02603
Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11168584]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 17825064]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 9038340]; GO_function: GO:0016887 - ATPase activity [Evidence IMP] [PMID 9038340]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11168584]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA,IGI] [PMID 16581798]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 9335335]
phosphatidylinositol/phosphatidylcholine transfer protein SEC14
Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1997207]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 7816798]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 1997207]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 12869188]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2466847]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA,IMP] [PMID 10488334]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 10848624]; GO_function: GO:0008525 - phosphatidylcholine transporter activity [Evidence IDA] [PMID 2407740]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA,IMP] [PMID 10848624]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA,IMP] [PMID 2215682]; GO_function: GO:0008526 - phosphatidylinositol transporter activity [Evidence IDA] [PMID 2407740]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 10848624]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 19129178]; GO_process: GO:0043001 - Golgi to plasma membrane protein transport [Evidence IMP] [PMID 6754086]; GO_process: GO:0006896 - Golgi to vacuole transport [Evidence IGI,IMP] [PMID 18753406]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IDA] [PMID 9553090]; GO_process: GO:0048194 - Golgi vesicle budding [Evidence IDA] [PMID 9736710]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 14528019]; GO_process: GO:2001246 - negative regulation of phosphatidylcholine biosynthetic process [Evidence IDA,IMP] [PMID 7816798]; GO_process: GO:1901352 - negative regulation of phosphatidylglycerol biosynthetic process [Evidence IMP] [PMID 12869188]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IGI,IMP] [PMID 10567405]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 10848624]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA,IMP] [PMID 2215682]; GO_process: GO:0015914 - phospholipid transport [Evidence IDA] [PMID 2407740]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14301
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 11823431]; GO_component: GO:0031080 - nuclear pore outer ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 22331846]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 21818277]; GO_process: GO:0006302 - double-strand break repair [Evidence IGI] [PMID 15725626]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 16418532]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 17538013]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 8565072]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 18258809]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0035392 - maintenance of chromatin silencing at telomere [Evidence IMP] [PMID 16418532]; GO_process: GO:0031081 - nuclear pore distribution [Evidence IMP] [PMID 8565072]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 22110603]; GO_process: GO:0045893 - positive regulation of transcription, DNA-templated [Evidence IDA,IGI,IMP] [PMID 15817685]; GO_process: GO:0000973 - posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [Evidence IMP] [PMID 20932479]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 12730220]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0034398 - telomere tethering at nuclear periphery [Evidence IMP] [PMID 16418532]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K03163
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IPI] [PMID 10967121]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6088500]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IEA,IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IMP] [PMID 2989818]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IDA] [PMID 6088500]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IEA]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IBA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 2549254]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IMP] [PMID 2989818]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 6088500]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 9199287]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 10082585]; GO_process: GO:0007076 - mitotic chromosome condensation [Evidence IGI,IMP] [PMID 8895658]; GO_process: GO:0007097 - nuclear migration [Evidence IGI,IMP] [PMID 8895658]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 2902925]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1660829]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 2840207]
similar to AA sequence:KEGG_Orthology:K17662
Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 23509072]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 11522252]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005761 - mitochondrial ribosome [Evidence IDA] [PMID 21670217]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11522252]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043022 - ribosome binding [Evidence IDA,IPI] [PMID 21670217]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 11522252]; GO_process: GO:0034551 - mitochondrial respiratory chain complex III assembly [Evidence IMP] [PMID 15759116]; GO_process: GO:0070131 - positive regulation of mitochondrial translation [Evidence IMP] [PMID 21670217]
Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35; GO_component: GO:0072546 - ER membrane protein complex [Evidence IDA] [PMID 19325107]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IGI] [PMID 19325107]
similar to AA sequence:KEGG_Orthology:K17607
Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IMP,IPI] [PMID 11741537]
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0051287 - NAD binding [Evidence IEA]; GO_function: GO:0048037 - cofactor binding [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IEA]; GO_function: GO:0047964 - glyoxylate reductase activity [Evidence IMP] [PMID 17173333]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence ISS] [PMID 9341119]; GO_process: GO:0009436 - glyoxylate catabolic process [Evidence IMP] [PMID 17173333]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence ISS] [PMID 9341119]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 15082763]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IGI,IMP,IPI] [PMID 9819425]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP,IPI] [PMID 15082763]; GO_process: GO:0034063 - stress granule assembly [Evidence IMP] [PMID 18981231]
similar to AA sequence:KEGG_Orthology:K15219
Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 7958901]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8702872]; GO_component: GO:0070860 - RNA polymerase I core factor complex [Evidence IDA] [PMID 8887672]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22362748]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0001164 - RNA polymerase I CORE element sequence-specific DNA binding [Evidence IDA] [PMID 18451108]; GO_function: GO:0001187 - RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [Evidence IC]; GO_function: GO:0017025 - TBP-class protein binding [Evidence IDA,IPI] [PMID 8702872]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006361 - transcription initiation from RNA polymerase I promoter [Evidence NAS] [PMID 7958901]; GO_process: GO:0042790 - transcription of nuclear large rRNA transcript from RNA polymerase I promoter [Evidence IDA,IMP] [PMID 7958901]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00560
Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8132557]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IMP] [PMID 334734]; GO_function: GO:0004799 - thymidylate synthase activity [Evidence IDA] [PMID 6287238]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IEA]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 334734]; GO_process: GO:0006231 - dTMP biosynthetic process [Evidence IMP] [PMID 794696]; GO_process: GO:0006235 - dTTP biosynthetic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02932
Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IEA]; GO_function: GO:0008097 - 5S rRNA binding [Evidence IDA] [PMID 8764831]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 8474444]; GO_process: GO:0006412 - translation [Evidence IEA]
Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IEP,ISS] [PMID 14534306]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEP,ISS] [PMID 14534306]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10884
Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IEA]; GO_component: GO:0043564 - Ku70:Ku80 complex [Evidence IDA] [PMID 8754818]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0000790 - nuclear chromatin [Evidence TAS] [PMID 10367891]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 10638763]; GO_component: GO:0005724 - nuclear telomeric heterochromatin [Evidence TAS] [PMID 12080091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004003 - ATP-dependent DNA helicase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 12975323]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence TAS] [PMID 10367891]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0042162 - telomeric DNA binding [Evidence IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 11553718]; GO_process: GO:0006342 - chromatin silencing [Evidence IDA,IMP] [PMID 9501103]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI,IMP] [PMID 18791224]; GO_process: GO:0000727 - double-strand break repair via break-induced replication [Evidence IGI,IMP] [PMID 17321803]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 11016833]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IMP] [PMID 10908335]; GO_process: GO:0097552 - mitochondrial double-strand break repair via homologous recombination [Evidence IMP] [PMID 22214610]; GO_process: GO:0000723 - telomere maintenance [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IMP] [PMID 10818099]
DNA polymerase epsilon catalytic subunit
similar to AA sequence:KEGG_Orthology:K02324
similar to AA sequence:KEGG_Orthology:K10847
Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotide excision repair; GO_component: GO:0000110 - nucleotide-excision repair factor 1 complex [Evidence IPI] [PMID 8621533]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852079]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IEA]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 23925126]; GO_function: GO:0003684 - damaged DNA binding [Evidence IDA] [PMID 8516285]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IDA] [PMID 8516285]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006289 - nucleotide-excision repair [Evidence IEA]; GO_process: GO:0000715 - nucleotide-excision repair, DNA damage recognition [Evidence IDA] [PMID 8516285]
similar to AA sequence:KEGG_Orthology:K02607
Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IMP] [PMID 9038340]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 7579692]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]; GO_process: GO:0031938 - regulation of chromatin silencing at telomere [Evidence IMP] [PMID 16980387]
similar to AA sequence:KEGG_Orthology:K12182
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p); GO_component: GO:0033565 - ESCRT-0 complex [Evidence IPI] [PMID 12055639]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 12055639]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 9702203]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 12055639]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 20150893]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0045324 - late endosome to vacuole transport [Evidence IMP] [PMID 12055639]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP,IPI] [PMID 12055639]
similar to AA sequence:KEGG_Orthology:K19476
Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18032584]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 18032584]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway [Evidence IGI] [PMID 18032584]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17807
Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16790493]; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 16943180]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 16790493]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 16943180]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_function: GO:0004605 - phosphatidate cytidylyltransferase activity [Evidence IDA,IMP] [PMID 23623749]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IMP] [PMID 19114592]; GO_process: GO:0032049 - cardiolipin biosynthetic process [Evidence IGI] [PMID 20485265]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Phosphoesterase; involved in downregulation of the unfolded protein response (UPR), at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IMP,ISS] [PMID 15590836]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004721 - phosphoprotein phosphatase activity [Evidence IDA,IMP] [PMID 17673172]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IDA] [PMID 16990850]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IGI,IMP] [PMID 16990850]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA] [PMID 16990850]; GO_process: GO:0006470 - protein dephosphorylation [Evidence IDA,IMP] [PMID 17673172]; GO_process: GO:0007089 - traversing start control point of mitotic cell cycle [Evidence IMP] [PMID 15590836]
similar to AA sequence:KEGG_Orthology:K14566
Putative PINc domain nuclease; required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16762320]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16769905]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA,IPI] [PMID 16769905]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16762320]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 16769905]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01887
Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004814 - arginine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004814 - arginine-tRNA ligase activity [Evidence IDA] [PMID 9622124]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006420 - arginyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006420 - arginyl-tRNA aminoacylation [Evidence IDA] [PMID 9622124]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15376
similar to AA sequence:KEGG_Orthology:K16261
Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10654085]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IGI] [PMID 14968425]; GO_function: GO:0015193 - L-proline transmembrane transporter activity [Evidence IMP] [PMID 3552672]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015175 - neutral amino acid transmembrane transporter activity [Evidence IDA] [PMID 10654085]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA,IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IDA,IGI] [PMID 8455553]; GO_process: GO:0015804 - neutral amino acid transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0015824 - proline transport [Evidence IDA] [PMID 10654085]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15322
Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA,IMP] [PMID 12925762]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IEA]; GO_component: GO:0000214 - tRNA-intron endonuclease complex [Evidence IDA] [PMID 9200603]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IEA]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IMP] [PMID 2182322]; GO_function: GO:0000213 - tRNA-intron endonuclease activity [Evidence IDA] [PMID 9200603]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation [Evidence IEA]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IMP] [PMID 2182322]; GO_process: GO:0000379 - tRNA-type intron splice site recognition and cleavage [Evidence IDA] [PMID 9200603]
similar to AA sequence:KEGG_Orthology:K12864
similar to AA sequence:KEGG_Orthology:K11648
Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 18644858]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8016655]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA] [PMID 8127913]; GO_component: GO:0016514 - SWI/SNF complex [Evidence IDA,IMP] [PMID 8159677]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000228 - nuclear chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 2233708]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IPI] [PMID 11865042]; GO_function: GO:0001102 - RNA polymerase II activating transcription factor binding [Evidence IMP,IPI] [PMID 14580348]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 14580348]; GO_process: GO:0006338 - chromatin remodeling [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IGI,IMP] [PMID 1459453]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IMP] [PMID 16024655]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 1339306]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI] [PMID 1901413]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 3542227]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0005987 - sucrose catabolic process [Evidence IMP] [PMID 6392017]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01892
Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 3521891]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 3521891]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IDA] [PMID 16741232]; GO_function: GO:0004821 - histidine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IMP] [PMID 1459448]; GO_process: GO:0006427 - histidyl-tRNA aminoacylation [Evidence IDA] [PMID 16741232]; GO_process: GO:0032543 - mitochondrial translation [Evidence IGI] [PMID 16777356]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03136
TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 1429681]; GO_component: GO:0005673 - transcription factor TFIIE complex [Evidence IDA] [PMID 7961670]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IPI] [PMID 11779853]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0001097 - TFIIH-class transcription factor binding [Evidence IDA] [PMID 8702741]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 9271406]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1331084]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 1429681]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 7961670]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9188494]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 9271406]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]; GO_process: GO:0001113 - transcriptional open complex formation at RNA polymerase II promoter [Evidence IDA,IGI] [PMID 10973956]
H(+)-transporting V0 sector ATPase subunit c
similar to AA sequence:KEGG_Orthology:K02155
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 15252052]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0033179 - proton-transporting V-type ATPase, V0 domain [Evidence IEA]; GO_component: GO:0033177 - proton-transporting two-sector ATPase complex, proton-transporting domain [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 10224039]; GO_component: GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain [Evidence TAS] [PMID 9442887]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015078 - hydrogen ion transmembrane transporter activity [Evidence TAS] [PMID 12482875]; GO_process: GO:0015991 - ATP hydrolysis coupled proton transport [Evidence IEA]; GO_process: GO:0006878 - cellular copper ion homeostasis [Evidence IMP] [PMID 9434348]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9434348]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 2145283]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 2145283]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence TAS] [PMID 12482875]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 10224039]; GO_process: GO:0007035 - vacuolar acidification [Evidence TAS] [PMID 9442887]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 2145283]
similar to AA sequence:KEGG_Orthology:K12862
Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; GO_component: GO:0000974 - Prp19 complex [Evidence IPI] [PMID 12088152]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IDA] [PMID 11884590]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 12554883]
similar to AA sequence:KEGG_Orthology:K19177
Putative prenyltransferase; required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11086160]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10515935]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14690591]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24390141]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14690591]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008834 - di-trans,poly-cis-decaprenylcistransferase activity [Evidence IEA]; GO_function: GO:0004659 - prenyltransferase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 16943325]
Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair; GO_component: GO:1990130 - Iml1 complex [Evidence IDA] [PMID 21900499]; GO_component: GO:0035859 - Seh1-associated complex [Evidence IDA] [PMID 21454883]; GO_component: GO:0097042 - extrinsic component of fungal-type vacuolar membrane [Evidence IDA] [PMID 21454883]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0034198 - cellular response to amino acid starvation [Evidence IMP] [PMID 19521502]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IMP] [PMID 18069899]; GO_process: GO:0032007 - negative regulation of TOR signaling [Evidence IMP] [PMID 19521502]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 24603354]; GO_process: GO:2000785 - regulation of autophagic vacuole assembly [Evidence IMP] [PMID 21900499]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10576
Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10811607]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 1869573]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 10811607]
Nem1-Spo7 phosphatase regulatory subunit SPO7
similar to AA sequence:KEGG_Orthology:K05288
ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence ISS] [PMID 10793139]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0051377 - mannose-ethanolamine phosphotransferase activity [Evidence IMP] [PMID 12441642]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 10793139]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 12441642]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Integral membrane protein of the early Golgi apparatus and ER; involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 16957051]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0030173 - integral component of Golgi membrane [Evidence IDA] [PMID 16107716]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 16957051]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0097020 - COPII adaptor activity [Evidence IMP,IPI] [PMID 20236934]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IDA,IMP] [PMID 16957051]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 16107716]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 16107716]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 16107716]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
ribose phosphate diphosphokinase subunit PRS2
similar to AA sequence:KEGG_Orthology:K00948
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IEA,IEA]; GO_function: GO:0004749 - ribose phosphate diphosphokinase activity [Evidence IGI] [PMID 15280369]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IEA]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IMP] [PMID 10212224]; GO_process: GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process [Evidence IGI] [PMID 15280369]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IPI] [PMID 15470112]; GO_process: GO:0009165 - nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0009156 - ribonucleoside monophosphate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15283
Protein involved in ER-to-Golgi transport; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23613772]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 1903839]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01262
Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 18281282]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0034396 - negative regulation of transcription from RNA polymerase II promoter in response to iron [Evidence IGI,IMP] [PMID 18281282]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05917
Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15951236]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004497 - monooxygenase activity [Evidence IEA,IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IEA]; GO_function: GO:0008398 - sterol 14-demethylase activity [Evidence IDA] [PMID 9087488]; GO_process: GO:0070988 - demethylation [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005635 - nuclear envelope [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 10525531]; GO_process: GO:0006606 - protein import into nucleus [Evidence IDA,IMP] [PMID 10525531]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein necessary for stability of L-A dsRNA-containing particles; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044419 - interspecies interaction between organisms [Evidence IMP] [PMID 3551911]
similar to AA sequence:KEGG_Orthology:K14297
similar to AA sequence:KEGG_Orthology:K04799
5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 19699691]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19699691]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IEA]; GO_function: GO:0008409 - 5'-3' exonuclease activity [Evidence IDA] [PMID 9166764]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IEA]; GO_function: GO:0017108 - 5'-flap endonuclease activity [Evidence IDA] [PMID 11825897]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004527 - exonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IEA]; GO_process: GO:0043137 - DNA replication, removal of RNA primer [Evidence IDA] [PMID 16837458]; GO_process: GO:0006284 - base-excision repair [Evidence IEA]; GO_process: GO:0006286 - base-excision repair, base-free sugar-phosphate removal [Evidence IGI,IMP] [PMID 9927726]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006303 - double-strand break repair via nonhomologous end joining [Evidence IDA] [PMID 15342630]; GO_process: GO:0000734 - gene conversion at mating-type locus, DNA repair synthesis [Evidence IMP] [PMID 10025407]; GO_process: GO:0035753 - maintenance of DNA trinucleotide repeats [Evidence IGI,IMP] [PMID 16079237]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA,IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 12024027]
DNA-(apurinic or apyrimidinic site) lyase APN1
similar to AA sequence:KEGG_Orthology:K10771
Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11238901]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7690756]; GO_function: GO:0017005 - 3'-tyrosyl-DNA phosphodiesterase activity [Evidence IDA] [PMID 12397185]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 12767225]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IMP,ISS] [PMID 1693433]; GO_function: GO:0008311 - double-stranded DNA 3'-5' exodeoxyribonuclease activity [Evidence IDA] [PMID 16024777]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008081 - phosphoric diester hydrolase activity [Evidence IDA] [PMID 3056935]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000737 - DNA catabolic process, endonucleolytic [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006284 - base-excision repair [Evidence IDA] [PMID 9295360]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]
arrestin (or S-antigen), N-terminal domain protein
replication factor A subunit protein RFA1
similar to AA sequence:KEGG_Orthology:K07466
similar to AA sequence:KEGG_Orthology:K14767
Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 12068309]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9611201]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15489292]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12068309]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
RNA-binding protein involved in meiosis Mei2
similar to AA sequence:KEGG_Orthology:K02516
Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10490648]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10805747]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0032174 - cellular bud neck septin collar [Evidence IDA] [PMID 23389636]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_function: GO:0008469 - histone-arginine N-methyltransferase activity [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 16426232]; GO_function: GO:0035241 - protein-arginine omega-N monomethyltransferase activity [Evidence IDA] [PMID 18515076]; GO_function: GO:0035243 - protein-arginine omega-N symmetric methyltransferase activity [Evidence IDA] [PMID 18515076]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0000086 - G2/M transition of mitotic cell cycle [Evidence IGI,IMP] [PMID 10490630]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0044257 - cellular protein catabolic process [Evidence IMP] [PMID 23042131]; GO_process: GO:0034969 - histone arginine methylation [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0006479 - protein methylation [Evidence IEA]; GO_process: GO:0051726 - regulation of cell cycle [Evidence IMP] [PMID 8647431]
similar to AA sequence:KEGG_Orthology:K14792
RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 8896463]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0008266 - poly(U) RNA binding [Evidence IDA] [PMID 16428605]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 8896463]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K07304
Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 20799725]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016671 - oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Evidence IEA]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IEA,IEA]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IDA,IMP] [PMID 15141092]; GO_function: GO:0008113 - peptide-methionine (S)-S-oxide reductase activity [Evidence IDA,IMP,ISS] [PMID 9275166]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IGI,IMP] [PMID 11929995]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 9275166]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0030091 - protein repair [Evidence IEA]; GO_process: GO:0006979 - response to oxidative stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01443
similar to AA sequence:KEGG_Orthology:K01207
similar to AA sequence:KEGG_Orthology:K00844
Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11311123]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9563516]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16962558]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11311123]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9563516]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IEA,IEA]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 12611889]; GO_function: GO:0004396 - hexokinase activity [Evidence IDA] [PMID 332086]; GO_function: GO:0004396 - hexokinase activity [Evidence IMP] [PMID 6341351]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0046835 - carbohydrate phosphorylation [Evidence IEA,IEA]; GO_process: GO:0032445 - fructose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006000 - fructose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0046323 - glucose import [Evidence IGI] [PMID 6300872]; GO_process: GO:0006006 - glucose metabolic process [Evidence IMP] [PMID 6300872]; GO_process: GO:0006096 - glycolytic process [Evidence IEA,IEA]; GO_process: GO:0006096 - glycolytic process [Evidence IDA] [PMID 332086]; GO_process: GO:0006096 - glycolytic process [Evidence IDA,IMP] [PMID 8917466]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0006013 - mannose metabolic process [Evidence IDA] [PMID 332086]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 12089449]; GO_process: GO:0046015 - regulation of transcription by glucose [Evidence IDA] [PMID 11311123]; GO_process: GO:0001302 - replicative cell aging [Evidence IMP] [PMID 15722108]
similar to AA sequence:KEGG_Orthology:K00451
Mediator of RNA polymerase II transcription subunit 18
similar to AA sequence:KEGG_Orthology:K15136
similar to AA sequence:KEGG_Orthology:K14843
Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0044786 - cell cycle DNA replication [Evidence IMP] [PMID 12110181]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 12837249]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 11911362]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IDA] [PMID 16888624]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01178
Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 2493265]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004339 - glucan 1,4-alpha-glucosidase activity [Evidence IEA,IEA]; GO_function: GO:0004339 - glucan 1,4-alpha-glucosidase activity [Evidence IDA] [PMID 2493265]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0030437 - ascospore formation [Evidence IEP] [PMID 350852]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0005980 - glycogen catabolic process [Evidence IMP] [PMID 11486014]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0000272 - polysaccharide catabolic process [Evidence IEA]; GO_process: GO:0005976 - polysaccharide metabolic process [Evidence IEA]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08853
similar to AA sequence:KEGG_Orthology:K09650
Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 12774122]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 12774122]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IMP] [PMID 20558178]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 11907266]; GO_process: GO:0010821 - regulation of mitochondrion organization [Evidence IMP] [PMID 12707284]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
similar to AA sequence:KEGG_Orthology:K04554
Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8396728]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016881 - acid-amino acid ligase activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 18191224]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 8396728]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 18191224]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 8393731]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 8396728]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 8641272]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 8781238]; GO_process: GO:0006513 - protein monoubiquitination [Evidence IDA,IMP] [PMID 8396728]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 19345192]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
U4/U6.U5 small nuclear ribonucleoprotein
similar to AA sequence:KEGG_Orthology:K15053
UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14755638]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030435 - sporulation resulting in formation of a cellular spore [Evidence IMP] [PMID 14755638]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 14755638]
similar to AA sequence:KEGG_Orthology:K01568
Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 2665820]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16850348]; GO_function: GO:0047433 - branched-chain-2-oxoacid decarboxylase activity [Evidence IMP] [PMID 9546164]; GO_function: GO:0016831 - carboxy-lyase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IEA]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 23423327]; GO_function: GO:0004737 - pyruvate decarboxylase activity [Evidence IDA] [PMID 2404950]; GO_function: GO:0030976 - thiamine pyrophosphate binding [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IEA]; GO_process: GO:0006559 - L-phenylalanine catabolic process [Evidence IGI] [PMID 12499363]; GO_process: GO:0000955 - amino acid catabolic process via Ehrlich pathway [Evidence IEA]; GO_process: GO:0000949 - aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0009083 - branched-chain amino acid catabolic process [Evidence IEA]; GO_process: GO:0019655 - glucose catabolic process to ethanol [Evidence IDA] [PMID 2404950]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006090 - pyruvate metabolic process [Evidence IDA] [PMID 2404950]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IEA]; GO_process: GO:0006569 - tryptophan catabolic process [Evidence IGI] [PMID 12499363]
Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06660
Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rholp guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10594031]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9819423]; GO_component: GO:0000922 - spindle pole [Evidence IDA] [PMID 10594031]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 16763112]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 12637549]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA,IMP] [PMID 17122856]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA,IMP] [PMID 8321244]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0010696 - positive regulation of spindle pole body separation [Evidence IGI,IMP] [PMID 18500339]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 16763112]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 17122856]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA,IMP] [PMID 8321244]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IMP] [PMID 12717442]; GO_process: GO:0090306 - spindle assembly involved in meiosis [Evidence IMP] [PMID 20237423]; GO_process: GO:0070194 - synaptonemal complex disassembly [Evidence IGI] [PMID 18832066]
similar to AA sequence:KEGG_Orthology:K11644
similar to AA sequence:KEGG_Orthology:K18932
Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 16647879]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016409 - palmitoyltransferase activity [Evidence IMP] [PMID 16818716]; GO_function: GO:0019706 - protein-cysteine S-palmitoyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16751107]; GO_process: GO:0018345 - protein palmitoylation [Evidence IMP] [PMID 16818716]
similar to AA sequence:KEGG_Orthology:K01755
Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_function: GO:0004056 - argininosuccinate lyase activity [Evidence IEA,IEA]; GO_function: GO:0004056 - argininosuccinate lyase activity [Evidence IDA] [PMID 4578972]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0006526 - arginine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0042450 - arginine biosynthetic process via ornithine [Evidence IEA]; GO_process: GO:0042450 - arginine biosynthetic process via ornithine [Evidence IDA] [PMID 4578972]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12765
similar to AA sequence:KEGG_Orthology:K06682
GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 19154724]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 12048186]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 10688190]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence TAS] [PMID 16039591]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00053
Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 10869431]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 18193418]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 18023287]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IEA,IEA]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IMP] [PMID 14124940]; GO_function: GO:0004455 - ketol-acid reductoisomerase activity [Evidence IMP] [PMID 3027658]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IMP] [PMID 14124940]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 18826960]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 7621838]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14824
Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1; GO_component: GO:0070545 - PeBoW complex [Evidence IDA,IPI] [PMID 16287855]; GO_component: GO:0005730 - nucleolus [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IEA]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 17443350]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0043021 - ribonucleoprotein complex binding [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 11522832]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IEA]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IPI] [PMID 16287855]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12831
U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM); GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 9436903]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP,IPI] [PMID 9436903]
Protein involved in mating response; invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9742096]; GO_function: GO:0032093 - SAM domain binding [Evidence IDA] [PMID 16337230]; GO_function: GO:0019887 - protein kinase regulator activity [Evidence IDA,IPI] [PMID 10397774]; GO_process: GO:0000161 - MAPK cascade involved in osmosensory signaling pathway [Evidence IMP,IPI] [PMID 9742096]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007050 - cell cycle arrest [Evidence IEA]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 12455951]; GO_process: GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor [Evidence IMP] [PMID 11370856]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP,IPI] [PMID 8793874]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IMP,IPI] [PMID 9738877]
similar to AA sequence:KEGG_Orthology:K00966
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IEA]; GO_function: GO:0004475 - mannose-1-phosphate guanylyltransferase activity [Evidence IDA,IMP] [PMID 9195935]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IEA]; GO_process: GO:0009298 - GDP-mannose biosynthetic process [Evidence IDA,IMP] [PMID 9195935]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 11055399]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9195935]
similar to AA sequence:KEGG_Orthology:K08955
Catalytic subunit of the i-AAA protease complex; complex is located in the mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as a nonconventional translocation motor to pull PNPase into the intermembrane space; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover; GO_component: GO:0031942 - i-AAA complex [Evidence IDA] [PMID 16267274]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 8688560]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 15772085]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IGI] [PMID 8688560]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 18843051]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 22993211]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence IDA,IMP] [PMID 16966379]; GO_process: GO:0051604 - protein maturation [Evidence IMP] [PMID 16966379]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01070
Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10427036]; GO_function: GO:0018738 - S-formylglutathione hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0018738 - S-formylglutathione hydrolase activity [Evidence IDA] [PMID 10427036]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IMP] [PMID 10427036]
Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication; GO_component: GO:0032177 - cellular bud neck split septin rings [Evidence IMP] [PMID 23442799]; GO_component: GO:0005934 - cellular bud tip [Evidence IMP] [PMID 23442799]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 18202552]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0032186 - cellular bud neck septin ring organization [Evidence IGI] [PMID 22570619]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI] [PMID 15146058]; GO_process: GO:0000132 - establishment of mitotic spindle orientation [Evidence IGI] [PMID 22570619]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 15146058]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IGI] [PMID 22570619]; GO_process: GO:0051865 - protein autoubiquitination [Evidence IDA] [PMID 18202552]; GO_process: GO:0097271 - protein localization to bud neck [Evidence IGI] [PMID 22570619]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IGI] [PMID 21562220]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 15146058]; GO_process: GO:0000921 - septin ring assembly [Evidence IGI] [PMID 22570619]
similar to AA sequence:KEGG_Orthology:K01638
Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 11846793]; GO_component: GO:0009514 - glyoxysome [Evidence IEA,IEA]; GO_component: GO:0005782 - peroxisomal matrix [Evidence IDA] [PMID 11846793]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 2211514]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IEA,IEA]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 23642236]; GO_function: GO:0004474 - malate synthase activity [Evidence IMP] [PMID 8878673]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 23642236]; GO_process: GO:0006097 - glyoxylate cycle [Evidence IMP] [PMID 8878673]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06942
P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 17430889]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18342
hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
Pentatricopeptide repeat-containing protein At1g62910
Pentatricopeptide repeat-containing protein
beta-glucan synthesis-associated protein KRE6
Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 17893149]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 7929594]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 21193403]; GO_component: GO:0030427 - site of polarized growth [Evidence IDA] [PMID 21193403]; GO_component: GO:0030133 - transport vesicle [Evidence IDA] [PMID 21193403]; GO_function: GO:0015926 - glucosidase activity [Evidence IMP,ISS] [PMID 10601196]; GO_process: GO:0006078 - (1->6)-beta-D-glucan biosynthetic process [Evidence IMP,ISS] [PMID 7929594]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 7929594]
Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IDA] [PMID 10468587]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP,ISS] [PMID 10468587]; GO_process: GO:0006880 - intracellular sequestering of iron ion [Evidence IMP] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IEA]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10468587]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 10588895]; GO_process: GO:0016226 - iron-sulfur cluster assembly [Evidence IMP] [PMID 12065597]
similar to AA sequence:KEGG_Orthology:K13126
Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15630021]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 15769879]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 17908917]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 19470581]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15630021]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15769879]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 8631901]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA,IMP] [PMID 9193001]; GO_function: GO:0008428 - ribonuclease inhibitor activity [Evidence IDA] [PMID 11889048]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0060211 - regulation of nuclear-transcribed mRNA poly(A) tail shortening [Evidence IDA,IMP] [PMID 17766253]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IDA,IMP] [PMID 10357826]; GO_process: GO:0006810 - transport [Evidence IEA]
Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IMP] [PMID 22927826]; GO_process: GO:0006644 - phospholipid metabolic process [Evidence IMP] [PMID 7706223]
Putative kinase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10866
similar to AA sequence:KEGG_Orthology:K15435
Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0030136 - clathrin-coated vesicle [Evidence IDA] [PMID 14562095]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IEA]; GO_function: GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [Evidence IDA,IMP] [PMID 10734185]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004112 - cyclic-nucleotide phosphodiesterase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0009187 - cyclic nucleotide metabolic process [Evidence IDA] [PMID 10734185]
8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 10922370]; GO_function: GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [Evidence IDA,IMP] [PMID 15475388]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0030145 - manganese ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016462 - pyrophosphatase activity [Evidence IDA] [PMID 10922370]; GO_process: GO:0006281 - DNA repair [Evidence IMP] [PMID 15475388]; GO_process: GO:0009132 - nucleoside diphosphate metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01702
Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway; GO_component: GO:0009316 - 3-isopropylmalate dehydratase complex [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 4355481]; GO_function: GO:0003861 - 3-isopropylmalate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0003861 - 3-isopropylmalate dehydratase activity [Evidence IMP] [PMID 5724969]; GO_function: GO:0051539 - 4 iron, 4 sulfur cluster binding [Evidence IEA,IEA]; GO_function: GO:0051536 - iron-sulfur cluster binding [Evidence IEA]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 5724969]; GO_process: GO:0009098 - leucine biosynthetic process [Evidence IMP] [PMID 6323436]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05864
Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9191025]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 10942767]; GO_function: GO:0003755 - peptidyl-prolyl cis-trans isomerase activity [Evidence IDA] [PMID 9191025]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10942767]; GO_process: GO:0006457 - protein folding [Evidence IEA,IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA,IPI] [PMID 9927435]; GO_process: GO:0000413 - protein peptidyl-prolyl isomerization [Evidence IEA,IEA,IEA]; GO_process: GO:0042026 - protein refolding [Evidence IDA] [PMID 10942767]
similar to AA sequence:KEGG_Orthology:K08744
Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0008808 - cardiolipin synthase activity [Evidence IDA] [PMID 7564918]; GO_function: GO:0008808 - cardiolipin synthase activity [Evidence IMP] [PMID 9614098]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 18799619]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IDA] [PMID 7564918]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IMP] [PMID 9614098]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0007006 - mitochondrial membrane organization [Evidence IMP] [PMID 10777514]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09496
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007346 - regulation of mitotic cell cycle [Evidence IMP] [PMID 15319434]; GO_process: GO:0006417 - regulation of translation [Evidence IGI] [PMID 15319434]
similar to AA sequence:KEGG_Orthology:K17795
Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex); GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IDA] [PMID 15618217]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IPI] [PMID 7600576]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 11344168]; GO_function: GO:0015266 - protein channel activity [Evidence IMP] [PMID 15618217]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 18826960]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 11344168]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 15618217]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7600576]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7919535]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13123
similar to AA sequence:KEGG_Orthology:K00555
tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 7599275]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 7599275]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IEA]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IMP] [PMID 19602197]; GO_component: GO:0005637 - nuclear inner membrane [Evidence IDA] [PMID 7599275]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IEA]; GO_function: GO:0004809 - tRNA (guanine-N2-)-methyltransferase activity [Evidence IDA,IMP] [PMID 9801306]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 2426253]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence ISS] [PMID 11101532]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 15024427]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 18327269]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0001308 - negative regulation of chromatin silencing involved in replicative cell aging [Evidence IGI,IMP] [PMID 9150138]; GO_process: GO:0017148 - negative regulation of translation [Evidence IDA] [PMID 20427513]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IGI] [PMID 11101532]; GO_process: GO:0008104 - protein localization [Evidence IMP] [PMID 9150138]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01535
Plasma membrane H+-ATPase; pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 15536122]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11739806]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12469340]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IEA]; GO_function: GO:0008553 - hydrogen-exporting ATPase activity, phosphorylative mechanism [Evidence IDA] [PMID 17912695]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006754 - ATP biosynthetic process [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:1902600 - hydrogen ion transmembrane transport [Evidence IEA]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:1902906 - proteasome storage granule assembly [Evidence IMP] [PMID 23690178]; GO_process: GO:0015992 - proton transport [Evidence IEA]; GO_process: GO:0015992 - proton transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006885 - regulation of pH [Evidence IEP] [PMID 8929277]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8396147]; GO_process: GO:0006810 - transport [Evidence IEA]
Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins; GO_component: GO:0005737 - cytoplasm [Evidence IMP] [PMID 20080635]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15797381]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 15078868]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA] [PMID 15797381]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0071630 - nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20080635]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA] [PMID 15078868]; GO_process: GO:0042787 - protein ubiquitination involved in ubiquitin-dependent protein catabolic process [Evidence IDA,IMP] [PMID 15797381]; GO_process: GO:0051788 - response to misfolded protein [Evidence IMP] [PMID 15797381]
similar to AA sequence:KEGG_Orthology:K01485
Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IEA]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IDA] [PMID 15535715]; GO_function: GO:0004131 - cytosine deaminase activity [Evidence IDA] [PMID 9000374]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0044206 - UMP salvage [Evidence IEA]; GO_process: GO:0046087 - cytidine metabolic process [Evidence IMP] [PMID 10501935]; GO_process: GO:0019858 - cytosine metabolic process [Evidence IMP] [PMID 9000374]; GO_process: GO:0008655 - pyrimidine-containing compound salvage [Evidence IMP] [PMID 9000374]
similar to AA sequence:KEGG_Orthology:K01191
Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 3281936]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence ISS] [PMID 2675832]; GO_function: GO:0004559 - alpha-mannosidase activity [Evidence IDA] [PMID 3281936]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_function: GO:0015923 - mannosidase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence ISS] [PMID 2675832]; GO_process: GO:0006013 - mannose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009313 - oligosaccharide catabolic process [Evidence IMP] [PMID 12723970]
similar to AA sequence:KEGG_Orthology:K19245
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0051213 - dioxygenase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0000907 - sulfonate dioxygenase activity [Evidence IDA] [PMID 10482536]; GO_process: GO:0046306 - alkanesulfonate catabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0044273 - sulfur compound catabolic process [Evidence IMP] [PMID 10482536]
similar to AA sequence:KEGG_Orthology:K14312
Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0044611 - nuclear pore inner ring [Evidence IDA] [PMID 18046406]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IEA]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 12509452]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 17418788]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IMP] [PMID 19414606]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 19414608]; GO_function: GO:0017056 - structural constituent of nuclear pore [Evidence IGI] [PMID 20498018]; GO_process: GO:0007059 - chromosome segregation [Evidence IMP] [PMID 11290711]; GO_process: GO:0070869 - heterochromatin assembly involved in chromatin silencing [Evidence IMP] [PMID 23452847]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0007094 - mitotic spindle assembly checkpoint [Evidence IGI,IMP,IPI] [PMID 12473689]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 19414608]; GO_process: GO:0051292 - nuclear pore complex assembly [Evidence IGI] [PMID 20498018]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IEA]; GO_process: GO:0006913 - nucleocytoplasmic transport [Evidence IC] [PMID 10684247]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0036228 - protein targeting to nuclear inner membrane [Evidence IMP] [PMID 21659568]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 23019326]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 10821185]; GO_process: GO:0071469 - cellular response to alkalinity [Evidence IMP] [PMID 23019326]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI,IMP] [PMID 16524906]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10821185]
similar to AA sequence:KEGG_Orthology:K02606
Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
similar to AA sequence:KEGG_Orthology:K13205
similar to AA sequence:KEGG_Orthology:K13341
Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP); GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15545321]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 7957058]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15545321]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 7535304]; GO_function: GO:0005053 - peroxisome matrix targeting signal-2 binding [Evidence IPI] [PMID 8636211]; GO_function: GO:0005053 - peroxisome matrix targeting signal-2 binding [Evidence IDA] [PMID 8670791]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 10087260]; GO_process: GO:0016560 - protein import into peroxisome matrix, docking [Evidence IPI] [PMID 9094717]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00797
Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IEA]; GO_function: GO:0004766 - spermidine synthase activity [Evidence IMP,ISS] [PMID 9073064]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006596 - polyamine biosynthetic process [Evidence IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008295 - spermidine biosynthetic process [Evidence IMP] [PMID 9073064]
similar to AA sequence:KEGG_Orthology:K01647
Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IEA,IEA]; GO_function: GO:0004108 - citrate (Si)-synthase activity [Evidence IDA,IMP] [PMID 17570335]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0046912 - transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Evidence IEA]; GO_process: GO:0046356 - acetyl-CoA catabolic process [Evidence IDA,IMP] [PMID 17570335]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006101 - citrate metabolic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006537 - glutamate biosynthetic process [Evidence TAS] [PMID 9175438]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence IEA,IEA,IEA]; GO_process: GO:0006099 - tricarboxylic acid cycle [Evidence TAS] [PMID 9175438]
similar to AA sequence:KEGG_Orthology:K01870
Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 7619074]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0002161 - aminoacyl-tRNA editing activity [Evidence IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IDA] [PMID 7619074]; GO_function: GO:0004822 - isoleucine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006428 - isoleucyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]; GO_process: GO:0006450 - regulation of translational fidelity [Evidence IEA]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]
Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 20477991]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 16301316]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006895 - Golgi to endosome transport [Evidence IMP] [PMID 16301316]; GO_process: GO:0000902 - cell morphogenesis [Evidence IMP,ISS] [PMID 10931277]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IMP] [PMID 16301316]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K19589
S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0035657 - eRF1 methyltransferase complex [Evidence IPI] [PMID 17008308]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA,IMP] [PMID 16321977]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IEA]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IDA] [PMID 15509572]; GO_function: GO:0008276 - protein methyltransferase activity [Evidence IDA] [PMID 17008308]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0018364 - peptidyl-glutamine methylation [Evidence IDA] [PMID 15509572]; GO_process: GO:0018364 - peptidyl-glutamine methylation [Evidence IDA] [PMID 17008308]; GO_process: GO:0006417 - regulation of translation [Evidence IDA] [PMID 15509572]; GO_process: GO:0006417 - regulation of translation [Evidence IDA] [PMID 16321977]
similar to AA sequence:KEGG_Orthology:K12869
Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11842115]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11842115]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0071008 - U2-type post-mRNA release spliceosomal complex [Evidence IDA] [PMID 11105756]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 11105756]; GO_component: GO:0000785 - chromatin [Evidence IDA] [PMID 11973290]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 11973290]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 11973290]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 11842115]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 11105756]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP,IPI] [PMID 11973290]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence IMP,IPI] [PMID 10445879]; GO_process: GO:0000354 - cis assembly of pre-catalytic spliceosome [Evidence IMP] [PMID 12509417]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13095
Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 10376880]; GO_component: GO:0000243 - commitment complex [Evidence IDA] [PMID 9150140]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0045131 - pre-mRNA branch point binding [Evidence IDA] [PMID 9182766]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 9182766]
similar to AA sequence:KEGG_Orthology:K11801
NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 10341420]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097038 - perinuclear endoplasmic reticulum [Evidence IDA] [PMID 22586098]; GO_component: GO:0005840 - ribosome [Evidence IDA] [PMID 16702403]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence IMP] [PMID 22586098]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016722 - oxidoreductase activity, oxidizing metal ions [Evidence ISA] [PMID 10341420]; GO_function: GO:0016175 - superoxide-generating NADPH oxidase activity [Evidence IMP] [PMID 22586098]; GO_process: GO:0006915 - apoptotic process [Evidence IGI] [PMID 22586098]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0032956 - regulation of actin cytoskeleton organization [Evidence IMP] [PMID 22586098]
similar to AA sequence:KEGG_Orthology:K14402
Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IEA]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 10523662]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 9099738]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IPI] [PMID 9099738]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IEA]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00354
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 7836424]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 11038181]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031304 - intrinsic component of mitochondrial inner membrane [Evidence IDA] [PMID 19505460]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030061 - mitochondrial crista [Evidence IDA] [PMID 19505460]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19505460]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 11038181]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 12707284]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence ISA] [PMID 11038181]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0061025 - membrane fusion [Evidence IDA] [PMID 22977249]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IDA] [PMID 12566426]; GO_process: GO:0008053 - mitochondrial fusion [Evidence IMP,IPI] [PMID 12808034]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 1532158]; GO_process: GO:0007005 - mitochondrion organization [Evidence IMP] [PMID 15125685]
similar to AA sequence:KEGG_Orthology:K00693
Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004373 - glycogen (starch) synthase activity [Evidence IEA,IEA]; GO_function: GO:0004373 - glycogen (starch) synthase activity [Evidence IDA] [PMID 2123485]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0005978 - glycogen biosynthetic process [Evidence IGI,IMP,ISS] [PMID 1908457]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004301 - epoxide hydrolase activity [Evidence IDA,ISS] [PMID 15769598]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009636 - response to toxic substance [Evidence ISS] [PMID 15769598]
Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 9559855]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 9742088]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 20371607]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IDA] [PMID 9742088]; GO_function: GO:0005371 - tricarboxylate secondary active transmembrane transporter activity [Evidence IDA] [PMID 20371607]; GO_function: GO:0005371 - tricarboxylate secondary active transmembrane transporter activity [Evidence IDA] [PMID 9559855]; GO_process: GO:0015742 - alpha-ketoglutarate transport [Evidence IDA] [PMID 20371607]; GO_process: GO:0006843 - mitochondrial citrate transport [Evidence IDA] [PMID 20371607]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 9742088]; GO_process: GO:0006842 - tricarboxylic acid transport [Evidence IDA] [PMID 9559855]
similar to AA sequence:KEGG_Orthology:K18192
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 2141026]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IPI] [PMID 14998992]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 22842922]; GO_function: GO:0051082 - unfolded protein binding [Evidence IPI] [PMID 14998992]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IEA]; GO_process: GO:0033615 - mitochondrial proton-transporting ATP synthase complex assembly [Evidence IMP,IPI] [PMID 14998992]
similar to AA sequence:KEGG_Orthology:K10901
similar to AA sequence:KEGG_Orthology:K14288
Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18045534]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0016363 - nuclear matrix [Evidence IDA] [PMID 8366091]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IDA] [PMID 9774653]; GO_function: GO:0000049 - tRNA binding [Evidence IEA]; GO_function: GO:0000049 - tRNA binding [Evidence TAS] [PMID 11959996]; GO_process: GO:0006409 - tRNA export from nucleus [Evidence IMP] [PMID 9802895]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0071528 - tRNA re-export from nucleus [Evidence IGI] [PMID 20032305]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00586
Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IEA,IEA]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IMP] [PMID 1508200]; GO_function: GO:0004164 - diphthine synthase activity [Evidence IDA] [PMID 3042777]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA,IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 1508200]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IDA] [PMID 3042777]
mitochondrial 54S ribosomal protein YmL40
similar to AA sequence:KEGG_Orthology:K02895
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
acetolactate synthase regulatory subunit
similar to AA sequence:KEGG_Orthology:K01653
Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria; GO_component: GO:0005948 - acetolactate synthase complex [Evidence IDA] [PMID 10213630]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IDA] [PMID 15692048]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IEA]; GO_function: GO:0003984 - acetolactate synthase activity [Evidence IDA] [PMID 8972574]; GO_function: GO:0016597 - amino acid binding [Evidence IEA]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 8972574]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009082 - branched-chain amino acid biosynthetic process [Evidence IDA,ISS] [PMID 8972574]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009097 - isoleucine biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009099 - valine biosynthetic process [Evidence IEA]
Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10725229]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0000176 - nuclear exosome (RNase complex) [Evidence IDA] [PMID 19046973]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10725229]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0048471 - perinuclear region of cytoplasm [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 7622450]; GO_process: GO:0006606 - protein import into nucleus [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 19141610]; GO_process: GO:0006612 - protein targeting to membrane [Evidence IMP] [PMID 16929305]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03283
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 10745074]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IGI] [PMID 3302682]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 8151709]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence ISS] [PMID 8151709]; GO_function: GO:0051082 - unfolded protein binding [Evidence IGI] [PMID 9789005]; GO_process: GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation [Evidence IMP] [PMID 8754838]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 24855027]; GO_process: GO:0006457 - protein folding [Evidence IGI] [PMID 9789005]; GO_process: GO:0006950 - response to stress [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00799
EFY87247|glutathione S-transferase [Metarhizium acridum CQMa 102]
Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
similar to AA sequence:KEGG_Orthology:K01539
High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 24124599]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 9092527]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence IDA] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IEA,IEA]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IDA,IMP] [PMID 10545175]; GO_function: GO:0005388 - calcium-transporting ATPase activity [Evidence IMP] [PMID 1379856]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0015410 - manganese-transporting ATPase activity [Evidence IDA] [PMID 10801856]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0070588 - calcium ion transmembrane transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IEA,IEA]; GO_process: GO:0006816 - calcium ion transport [Evidence IDA,IMP] [PMID 10545175]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006874 - cellular calcium ion homeostasis [Evidence IGI] [PMID 23569283]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 1379856]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0006828 - manganese ion transport [Evidence IDA] [PMID 10801856]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03685
Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15090619]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15090619]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IEA,IEA]; GO_function: GO:0004525 - ribonuclease III activity [Evidence IDA] [PMID 15766245]; GO_process: GO:0090501 - RNA phosphodiester bond hydrolysis [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA,IEA]; GO_process: GO:0006396 - RNA processing [Evidence IEA]; GO_process: GO:0034473 - U1 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034963 - box C/D snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0034964 - box H/ACA snoRNA processing [Evidence IMP] [PMID 23201338]; GO_process: GO:0006325 - chromatin organization [Evidence IMP] [PMID 17991894]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA,IMP] [PMID 17158880]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 17991894]; GO_process: GO:0009303 - rRNA transcription [Evidence IMP] [PMID 17991894]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 22576366]; GO_process: GO:0030847 - termination of RNA polymerase II transcription, exosome-dependent [Evidence IDA,IMP,IPI] [PMID 19818713]
similar to AA sequence:KEGG_Orthology:K12829
Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 15565172]; GO_component: GO:0005686 - U2 snRNP [Evidence IDA] [PMID 16314500]; GO_component: GO:0071004 - U2-type prespliceosome [Evidence IDA] [PMID 16618970]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 16314500]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IDA] [PMID 8566755]
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
adhesion and aggregation factor identified by ability to make transformed S. cerevisiae clump and stick to polystyrene beads
similar to AA sequence:KEGG_Orthology:K10685
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; GO_component: GO:0031510 - SUMO activating enzyme complex [Evidence IPI] [PMID 9312010]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 7629121]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019948 - SUMO activating enzyme activity [Evidence IDA,IMP] [PMID 9312010]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008641 - small protein activating enzyme activity [Evidence IEA]; GO_process: GO:0006464 - cellular protein modification process [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IEA]; GO_process: GO:0016925 - protein sumoylation [Evidence IDA,IMP] [PMID 9312010]
similar to AA sequence:KEGG_Orthology:K05289
Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IEA]; GO_component: GO:0042765 - GPI-anchor transamidase complex [Evidence IDA] [PMID 11598210]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003923 - GPI-anchor transamidase activity [Evidence IC] [PMID 11598210]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 11598210]; GO_process: GO:0016255 - attachment of GPI anchor to protein [Evidence IMP] [PMID 7730400]
Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes; GO_component: GO:0012505 - endomembrane system [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IPI] [PMID 9700157]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030905 - retromer complex, outer shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11984
Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 10619019]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 12183366]; GO_component: GO:0016586 - RSC complex [Evidence IDA] [PMID 14729968]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 12183366]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 16455496]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17188033]; GO_function: GO:0015616 - DNA translocase activity [Evidence IDA] [PMID 17918861]; GO_process: GO:0043044 - ATP-dependent chromatin remodeling [Evidence IDA] [PMID 12183366]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IMP] [PMID 12482937]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IC] [PMID 14729968]; GO_process: GO:0006337 - nucleosome disassembly [Evidence IDA] [PMID 16492771]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 2556404]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006368 - transcription elongation from RNA polymerase II promoter [Evidence IDA] [PMID 17081996]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06889
Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9575223]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008559 - xenobiotic-transporting ATPase activity [Evidence IDA,IMP] [PMID 23270647]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0042908 - xenobiotic transport [Evidence IDA,IMP] [PMID 23270647]
Neurospora crassa e-Compendium ncu10311.3
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0052851 - ferric-chelate reductase (NADPH) activity [Evidence IEA]; GO_function: GO:0000293 - ferric-chelate reductase activity [Evidence ISA] [PMID 9726978]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K13367
Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0052904 - N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052903 - N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IMP] [PMID 11154694]; GO_function: GO:0046592 - polyamine oxidase activity [Evidence IDA] [PMID 21067138]; GO_function: GO:0052902 - spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [Evidence IEA]; GO_function: GO:0052901 - spermine:oxygen oxidoreductase (spermidine-forming) activity [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IMP] [PMID 11154694]; GO_process: GO:0006598 - polyamine catabolic process [Evidence IGI,IMP] [PMID 12586697]
similar to AA sequence:KEGG_Orthology:K01488
Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IBA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0000034 - adenine deaminase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0000034 - adenine deaminase activity [Evidence IDA,IMP] [PMID 1577682]; GO_function: GO:0019239 - deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006146 - adenine catabolic process [Evidence IEA,IEA]; GO_process: GO:0006146 - adenine catabolic process [Evidence IDA,IMP] [PMID 1577682]; GO_process: GO:0043103 - hypoxanthine salvage [Evidence IEA]; GO_process: GO:0043103 - hypoxanthine salvage [Evidence IDA,IMP] [PMID 1577682]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IEA]; GO_process: GO:0009168 - purine ribonucleoside monophosphate biosynthetic process [Evidence IEA]; GO_process: GO:0043101 - purine-containing compound salvage [Evidence IDA,IMP] [PMID 1577682]
similar to AA sequence:KEGG_Orthology:K01180
Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; GO_component: GO:0030428 - cell septum [Evidence IDA] [PMID 12455695]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence ISS] [PMID 11747810]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 11935221]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence IGI] [PMID 12455695]; GO_function: GO:0052861 - glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0052862 - glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_process: GO:0016998 - cell wall macromolecule catabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IEP,ISS] [PMID 11747810]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 16328626]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08150
Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 2040626]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16233524]; GO_function: GO:0005365 - myo-inositol transmembrane transporter activity [Evidence IMP,ISS] [PMID 2040626]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015798 - myo-inositol transport [Evidence IMP] [PMID 2040626]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08499
Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0031201 - SNARE complex [Evidence IPI] [PMID 10397773]; GO_component: GO:0031901 - early endosome membrane [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9427746]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031902 - late endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 15973437]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IEA]; GO_function: GO:0005484 - SNAP receptor activity [Evidence IDA] [PMID 14981247]; GO_process: GO:0048193 - Golgi vesicle transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 9427746]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006906 - vesicle fusion [Evidence IDA] [PMID 11739407]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21441304]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IEA]; GO_component: GO:0005770 - late endosome [Evidence IDA] [PMID 21441304]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IGI,IMP,IPI] [PMID 21441304]; GO_process: GO:0006810 - transport [Evidence IEA]
Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 19520826]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19520826]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008821 - crossover junction endodeoxyribonuclease activity [Evidence IDA,IMP] [PMID 19020614]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA,IEA]; GO_function: GO:0000014 - single-stranded DNA endodeoxyribonuclease activity [Evidence ISS] [PMID 9683672]; GO_process: GO:0006281 - DNA repair [Evidence IEA,IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI] [PMID 20106725]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 20106725]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K06276
similar to AA sequence:KEGG_Orthology:K13289
Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 14562095]; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23708375]; GO_component: GO:0005773 - vacuole [Evidence IEA,IEA,IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004185 - serine-type carboxypeptidase activity [Evidence IDA,IMP] [PMID 8679540]; GO_process: GO:0046938 - phytochelatin biosynthetic process [Evidence IDA,IMP] [PMID 17408619]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence TAS] [PMID 8789256]
Sumoylated protein localizing to the nuclear periphery of mother cells; localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 18336552]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IGI] [PMID 15598824]; GO_process: GO:0016925 - protein sumoylation [Evidence IGI] [PMID 11606525]; GO_process: GO:0010224 - response to UV-B [Evidence IMP] [PMID 11606770]; GO_process: GO:0010224 - response to UV-B [Evidence IMP] [PMID 15598824]; GO_process: GO:0010225 - response to UV-C [Evidence IMP] [PMID 11606770]; GO_process: GO:0010225 - response to UV-C [Evidence IMP] [PMID 15598824]
similar to AA sequence:KEGG_Orthology:K02365
Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11149918]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11149918]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005819 - spindle [Evidence IDA] [PMID 11149918]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_function: GO:0004197 - cysteine-type endopeptidase activity [Evidence IDA] [PMID 11081625]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA,IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 18321989]; GO_process: GO:0007059 - chromosome segregation [Evidence IEA]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP,IPI] [PMID 9635435]; GO_process: GO:0034048 - negative regulation of protein phosphatase type 2A activity [Evidence IMP,IPI] [PMID 16713564]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence IGI,IPI] [PMID 12598903]; GO_process: GO:0032888 - regulation of mitotic spindle elongation [Evidence IGI,IMP] [PMID 18430955]
Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
S-methyl-5-thioribose-1-phosphate isomerase MRI1
similar to AA sequence:KEGG_Orthology:K08963
5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0046523 - S-methyl-5-thioribose-1-phosphate isomerase activity [Evidence IEA,IEA]; GO_function: GO:0046523 - S-methyl-5-thioribose-1-phosphate isomerase activity [Evidence IDA,ISS] [PMID 15215245]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 15215245]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0044249 - cellular biosynthetic process [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05535
Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 9756928]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IMP] [PMID 9756928]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IMP] [PMID 9756928]
similar to AA sequence:KEGG_Orthology:K15542
Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IC] [PMID 12819204]; GO_process: GO:0006379 - mRNA cleavage [Evidence IMP] [PMID 10619842]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 10619842]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 19665976]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 19665976]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IMP] [PMID 19665976]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0048309 - endoplasmic reticulum inheritance [Evidence IGI] [PMID 19665976]; GO_process: GO:0016320 - endoplasmic reticulum membrane fusion [Evidence IDA,IGI,IMP] [PMID 22508509]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IEA]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI,IGI] [PMID 19665976]; GO_process: GO:0007029 - endoplasmic reticulum organization [Evidence IGI] [PMID 22508509]; GO_process: GO:0061024 - membrane organization [Evidence IGI] [PMID 12427979]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Plasma membrane hypothetical protein; truncation and overexpression suppresses lethality of G-alpha protein deficiency; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 7592711]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 7592711]
similar to AA sequence:KEGG_Orthology:K01188
top hit is XP_007344833.1 originated in Auricularia delicata TFB-10046 SS5
putative aminophospholipid-translocating P4-type ATPase NEO1
similar to AA sequence:KEGG_Orthology:K01530
Putative aminophospholipid translocase (flippase); involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 15314152]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 12960419]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 15314152]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0015662 - ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Evidence ISS] [PMID 9224683]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence ISS] [PMID 12221123]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 15314152]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IEA,IEA]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 12960419]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007033 - vacuole organization [Evidence IMP] [PMID 15314152]
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; GO_component: GO:0070847 - core mediator complex [Evidence IDA] [PMID 9891034]; GO_component: GO:0016592 - mediator complex [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0001104 - RNA polymerase II transcription cofactor activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IDA] [PMID 9420330]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17794
Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IEA]; GO_component: GO:0005744 - mitochondrial inner membrane presequence translocase complex [Evidence IPI] [PMID 7600576]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015450 - P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Evidence IEA]; GO_function: GO:0030943 - mitochondrion targeting sequence binding [Evidence IDA,IMP] [PMID 8858146]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 11713477]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 10830167]; GO_process: GO:0030150 - protein import into mitochondrial matrix [Evidence IMP] [PMID 7600576]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00681
Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 6143574]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0003840 - gamma-glutamyltransferase activity [Evidence IMP] [PMID 11672438]; GO_function: GO:0036374 - glutathione hydrolase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0006751 - glutathione catabolic process [Evidence IMP] [PMID 11672438]; GO_process: GO:0006749 - glutathione metabolic process [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006805 - xenobiotic metabolic process [Evidence IMP] [PMID 16857395]
similar to AA sequence:KEGG_Orthology:K00706
Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IEA]; GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 7983071]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11856368]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8602515]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 11856368]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8602515]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 11856368]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17507646]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IEA,IEA]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA,IMP] [PMID 7528927]; GO_function: GO:0003843 - 1,3-beta-D-glucan synthase activity [Evidence IDA] [PMID 7649185]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IEA]; GO_process: GO:0006075 - (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 7528927]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0008360 - regulation of cell shape [Evidence IEA]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]
Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 18462190]; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005621 - cellular bud scar [Evidence IDA] [PMID 19793924]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 19793924]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 10716729]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 19541632]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 1824714]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 19793924]; GO_component: GO:0000936 - primary cell septum [Evidence IDA] [PMID 19793924]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 10809732]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 15355340]; GO_function: GO:0042124 - 1,3-beta-glucanosyltransferase activity [Evidence IDA] [PMID 17397106]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0006342 - chromatin silencing [Evidence IMP,IPI] [PMID 19541632]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 15645503]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16986442]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 9515908]
similar to AA sequence:KEGG_Orthology:K11135
Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9238021]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9238021]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 11694505]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 11274141]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IGI] [PMID 9238021]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 16651379]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0007088 - regulation of mitosis [Evidence IMP] [PMID 14697200]; GO_process: GO:0060188 - regulation of protein desumoylation [Evidence IMP,IPI] [PMID 17403926]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06268
Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress; GO_component: GO:0005955 - calcineurin complex [Evidence IPI] [PMID 10887154]; GO_component: GO:0005955 - calcineurin complex [Evidence IDA] [PMID 1321337]; GO_function: GO:0005509 - calcium ion binding [Evidence IEA]; GO_function: GO:0005509 - calcium ion binding [Evidence ISS] [PMID 11015619]; GO_function: GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity [Evidence IDA,ISS] [PMID 1321337]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 1321337]; GO_process: GO:0006873 - cellular ion homeostasis [Evidence IMP] [PMID 8798496]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI,IMP] [PMID 7530227]
similar to AA sequence:KEGG_Orthology:K11366
similar to AA sequence:KEGG_Orthology:K15026
similar to AA sequence:KEGG_Orthology:K11866
similar to AA sequence:KEGG_Orthology:K13719
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 16427015]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA] [PMID 16427015]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IMP] [PMID 15755922]
similar to AA sequence:KEGG_Orthology:K14821
C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23045392]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23212245]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11452010]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23212245]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23045392]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA,IDA] [PMID 23212245]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043023 - ribosomal large subunit binding [Evidence IDA] [PMID 23045392]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IMP] [PMID 11452010]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 23045392]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 23212245]
Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 10749875]; GO_function: GO:0031683 - G-protein beta/gamma-subunit complex binding [Evidence IDA] [PMID 10749875]; GO_function: GO:0003779 - actin binding [Evidence IDA,IMP] [PMID 19501098]; GO_process: GO:0009968 - negative regulation of signal transduction [Evidence IEA]; GO_process: GO:0007329 - positive regulation of transcription from RNA polymerase II promoter by pheromones [Evidence IMP,IPI] [PMID 10749875]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 19501098]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K09885
Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10092523]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0015250 - water channel activity [Evidence IGI,IMP,ISS] [PMID 9765289]; GO_process: GO:0030437 - ascospore formation [Evidence IMP] [PMID 15583134]; GO_process: GO:0006810 - transport [Evidence IEA,IEA,IEA]; GO_process: GO:0006833 - water transport [Evidence IMP] [PMID 9765289]
similar to AA sequence:KEGG_Orthology:K07055
S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IEA]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence ISS] [PMID 12872006]; GO_function: GO:0008757 - S-adenosylmethionine-dependent methyltransferase activity [Evidence IDA] [PMID 16005430]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IDA] [PMID 16642040]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 16005430]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IEA]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 16642040]; GO_process: GO:0031591 - wybutosine biosynthetic process [Evidence IMP] [PMID 17150819]
similar to AA sequence:KEGG_Orthology:K12763
Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence ISS] [PMID 8524252]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 11046133]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8524252]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14690591]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15282305]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02604
Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p; GO_component: GO:0031261 - DNA replication preinitiation complex [Evidence IDA] [PMID 9554851]; GO_component: GO:0005664 - nuclear origin of replication recognition complex [Evidence IDA,IMP] [PMID 9372948]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 16824194]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 9335335]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0000808 - origin recognition complex [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 16824194]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 9288745]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9159120]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 9288745]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 16716188]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI,IMP] [PMID 7579692]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IDA] [PMID 12897051]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 16980387]; GO_process: GO:0051568 - histone H3-K4 methylation [Evidence IMP] [PMID 18845545]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IDA] [PMID 16824194]
similar to AA sequence:KEGG_Orthology:K03146
Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 15544818]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 16850348]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0008198 - ferrous iron binding [Evidence IDA] [PMID 22031445]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 9367751]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009228 - thiamine biosynthetic process [Evidence IMP] [PMID 7941734]; GO_process: GO:0052837 - thiazole biosynthetic process [Evidence IEA]; GO_process: GO:0052837 - thiazole biosynthetic process [Evidence IDA] [PMID 22031445]
UV radiation resistance-associated gene protein
similar to AA sequence:KEGG_Orthology:K06636
Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; GO_component: GO:0005694 - chromosome [Evidence IEA,IEA,IEA]; GO_component: GO:0008278 - cohesin complex [Evidence IEA]; GO_component: GO:0034990 - nuclear mitotic cohesin complex [Evidence IDA] [PMID 9990856]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003680 - AT DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929577]; GO_function: GO:0000217 - DNA secondary structure binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0003682 - chromatin binding [Evidence IEA]; GO_function: GO:0003690 - double-stranded DNA binding [Evidence IDA] [PMID 9727028]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0046982 - protein heterodimerization activity [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IEA]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 11448778]; GO_process: GO:0006302 - double-strand break repair [Evidence IMP] [PMID 15280507]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI] [PMID 9335333]; GO_process: GO:0000070 - mitotic sister chromatid segregation [Evidence IMP] [PMID 8276886]
similar to AA sequence:KEGG_Orthology:K13333
Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10497163]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 10497163]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IMP,ISS] [PMID 10497163]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0046488 - phosphatidylinositol metabolic process [Evidence IDA,IMP] [PMID 10497163]; GO_process: GO:0006660 - phosphatidylserine catabolic process [Evidence IDA,IMP] [PMID 10497163]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21127045]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10648791]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 21127045]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 11212916]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 10648791]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA,IMP] [PMID 19906648]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IGI,IMP,ISS] [PMID 10648791]
similar to AA sequence:KEGG_Orthology:K15280
Putative nucleotide sugar transporter; has similarity to Vrg4p; GO_component: GO:0030137 - COPI-coated vesicle [Evidence IDA] [PMID 14562095]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005338 - nucleotide-sugar transmembrane transporter activity [Evidence ISS] [PMID 9395539]; GO_process: GO:0015786 - UDP-glucose transport [Evidence IMP] [PMID 18693752]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0015780 - nucleotide-sugar transport [Evidence ISS] [PMID 9395539]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14985124]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015495 - gamma-aminobutyric acid:proton symporter activity [Evidence IGI] [PMID 8455553]; GO_function: GO:0015489 - putrescine transmembrane transporter activity [Evidence IGI] [PMID 14985124]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0015812 - gamma-aminobutyric acid transport [Evidence IEP,IGI] [PMID 8455553]; GO_process: GO:0015847 - putrescine transport [Evidence IGI] [PMID 14985124]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IGI] [PMID 8455553]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00819
L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 205532]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004587 - ornithine-oxo-acid transaminase activity [Evidence IEA]; GO_function: GO:0004587 - ornithine-oxo-acid transaminase activity [Evidence IMP] [PMID 3036506]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0055129 - L-proline biosynthetic process [Evidence IEA]; GO_process: GO:0006527 - arginine catabolic process [Evidence NAS] [PMID 14263163]; GO_process: GO:0006527 - arginine catabolic process [Evidence IC] [PMID 3036506]; GO_process: GO:0006591 - ornithine metabolic process [Evidence IMP] [PMID 3036506]
similar to AA sequence:KEGG_Orthology:K05294
GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8862519]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 8862519]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0050185 - phosphatidylinositol deacylase activity [Evidence IGI] [PMID 14734546]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 8862519]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11673477]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IEA]; GO_process: GO:0006505 - GPI anchor metabolic process [Evidence IGI] [PMID 14734546]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006621 - protein retention in ER lumen [Evidence IMP] [PMID 8862519]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016050 - vesicle organization [Evidence IGI,IMP] [PMID 8862519]
similar to AA sequence:KEGG_Orthology:K11231
Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IDA] [PMID 10198019]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 14665464]; GO_component: GO:0005886 - plasma membrane [Evidence ISS] [PMID 8808622]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0009927 - histidine phosphotransfer kinase activity [Evidence IDA,IMP] [PMID 12455952]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0005034 - osmosensor activity [Evidence IDA] [PMID 12821642]; GO_function: GO:0000156 - phosphorelay response regulator activity [Evidence IEA]; GO_function: GO:0000155 - phosphorelay sensor kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IEA]; GO_function: GO:0004673 - protein histidine kinase activity [Evidence IDA] [PMID 8808622]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0006469 - negative regulation of protein kinase activity [Evidence IGI,IMP] [PMID 9482735]; GO_process: GO:0007234 - osmosensory signaling via phosphorelay pathway [Evidence IDA] [PMID 8808622]; GO_process: GO:0018106 - peptidyl-histidine phosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0000160 - phosphorelay signal transduction system [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA,IEA]; GO_process: GO:0046777 - protein autophosphorylation [Evidence IDA] [PMID 8808622]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0023014 - signal transduction by phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08158
Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10903515]; GO_function: GO:0015238 - drug transmembrane transporter activity [Evidence IEA]; GO_function: GO:0015244 - fluconazole transporter activity [Evidence ISS] [PMID 9235926]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI,IMP] [PMID 10572257]; GO_process: GO:0006855 - drug transmembrane transport [Evidence IGI] [PMID 9235926]; GO_process: GO:0015893 - drug transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence ISS] [PMID 9235926]; GO_process: GO:0006810 - transport [Evidence IEA]
RNA-binding protein, G-patch type (predicted)
similar to AA sequence:KEGG_Orthology:K08869
Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1; GO_component: GO:0032592 - integral component of mitochondrial membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 23781023]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0055088 - lipid homeostasis [Evidence IGI] [PMID 23781023]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0007005 - mitochondrion organization [Evidence IGI,IMP] [PMID 23781023]
Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 8631921]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IDA] [PMID 8631921]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0000032 - cell wall mannoprotein biosynthetic process [Evidence IMP] [PMID 8631921]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IMP] [PMID 8631921]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA,IEA]
DNA-directed RNA polymerase II subunit RPB4
similar to AA sequence:KEGG_Orthology:K03012
RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; the Rpb4p/Rpb7p subcomplex regulates cellular lifespan via an mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 1331084]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2183013]; GO_component: GO:0005665 - DNA-directed RNA polymerase II, core complex [Evidence IDA] [PMID 2186966]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12857861]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IEA]; GO_component: GO:0000932 - cytoplasmic mRNA processing body [Evidence IDA] [PMID 16357218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12857861]; GO_function: GO:0003899 - DNA-directed RNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003968 - RNA-directed RNA polymerase activity [Evidence IDA] [PMID 18004386]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IDA] [PMID 11087726]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IDA] [PMID 11087726]; GO_function: GO:0031369 - translation initiation factor binding [Evidence IPI] [PMID 21074047]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0031990 - mRNA export from nucleus in response to heat stress [Evidence IMP] [PMID 12857861]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Evidence IMP] [PMID 16357218]; GO_process: GO:0045948 - positive regulation of translational initiation [Evidence IMP] [PMID 21074047]; GO_process: GO:0034402 - recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [Evidence IMP] [PMID 18195044]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11577101]; GO_process: GO:0006367 - transcription initiation from RNA polymerase II promoter [Evidence IDA] [PMID 11087726]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01440
Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12736687]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12736687]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 12736687]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008936 - nicotinamidase activity [Evidence IEA]; GO_function: GO:0008936 - nicotinamidase activity [Evidence ISS] [PMID 11901108]; GO_function: GO:0008936 - nicotinamidase activity [Evidence IMP] [PMID 19381334]; GO_process: GO:0000183 - chromatin silencing at rDNA [Evidence IMP] [PMID 11901108]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 11901108]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0019358 - nicotinate nucleotide salvage [Evidence ISS] [PMID 11901108]; GO_process: GO:0019363 - pyridine nucleotide biosynthetic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 12736687]
similar to AA sequence:KEGG_Orthology:K01409
Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; GO_component: GO:0000408 - EKC/KEOPS complex [Evidence IDA] [PMID 16564010]; GO_component: GO:0000408 - EKC/KEOPS complex [Evidence IDA] [PMID 16874308]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 16874308]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0031490 - chromatin DNA binding [Evidence IDA] [PMID 16874308]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_function: GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups [Evidence IEA]; GO_process: GO:0051276 - chromosome organization [Evidence IMP] [PMID 18439903]; GO_process: GO:0045944 - positive regulation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 16874308]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006400 - tRNA modification [Evidence IDA] [PMID 23620299]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0000723 - telomere maintenance [Evidence IPI] [PMID 16564010]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI,IMP] [PMID 23390378]; GO_process: GO:0070526 - threonylcarbamoyladenosine biosynthetic process [Evidence IEA]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21183954]; GO_process: GO:0070525 - threonylcarbamoyladenosine metabolic process [Evidence IMP] [PMID 21459853]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08497
Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 12853481]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 12893879]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 9214619]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 8334998]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA,ISM] [PMID 1537327]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 19346454]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISM] [PMID 12853481]; GO_function: GO:0005484 - SNAP receptor activity [Evidence ISM] [PMID 12893879]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8612273]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence IC] [PMID 8612273]; GO_process: GO:0048279 - vesicle fusion with endoplasmic reticulum [Evidence NAS] [PMID 9214619]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17970
Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038180]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 11038182]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0043130 - ubiquitin binding [Evidence IDA] [PMID 21070969]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 11038180]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP,IPI] [PMID 11038182]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP] [PMID 11038183]; GO_process: GO:0000266 - mitochondrial fission [Evidence IGI,IMP,IPI] [PMID 11179417]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI,IMP] [PMID 11038182]; GO_process: GO:0016559 - peroxisome fission [Evidence IGI] [PMID 18445678]
similar to AA sequence:KEGG_Orthology:K09499
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
similar to AA sequence:KEGG_Orthology:K14775
Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IPI] [PMID 21724601]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 19446323]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19446323]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IDA,IPI] [PMID 19217412]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006298 - mismatch repair [Evidence IMP] [PMID 10681183]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IMP] [PMID 19217412]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI] [PMID 19412159]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446322]; GO_process: GO:0070682 - proteasome regulatory particle assembly [Evidence IGI,IMP] [PMID 19446323]
similar to AA sequence:KEGG_Orthology:K14829
Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p; GO_component: GO:0097344 - Rix1 complex [Evidence IDA] [PMID 14759368]; GO_component: GO:0005656 - nuclear pre-replicative complex [Evidence IDA] [PMID 22421151]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 15528184]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0003682 - chromatin binding [Evidence IDA] [PMID 22421151]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IMP] [PMID 22421151]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 14759368]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 22421151]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 15528184]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12598
ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15828860]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA] [PMID 15935758]; GO_component: GO:0031499 - TRAMP complex [Evidence IDA,IPI] [PMID 15935759]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16541108]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15226447]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 8756671]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA,IMP] [PMID 18000032]; GO_function: GO:0034459 - ATP-dependent 3'-5' RNA helicase activity [Evidence IDA] [PMID 18096702]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016817 - hydrolase activity, acting on acid anhydrides [Evidence IEA]; GO_function: GO:0016818 - hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0008143 - poly(A) binding [Evidence IDA] [PMID 18096702]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0034475 - U4 snRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0034476 - U5 snRNA 3'-end processing [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10508172]; GO_process: GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 9463390]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15828860]; GO_process: GO:0043629 - ncRNA polyadenylation [Evidence IDA] [PMID 15935758]; GO_process: GO:0071031 - nuclear mRNA surveillance of mRNA 3'-end processing [Evidence IGI,IMP] [PMID 17410208]; GO_process: GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process [Evidence IMP] [PMID 19369424]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16374505]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 18940861]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15828860]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 15935758]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IDA] [PMID 17643380]; GO_process: GO:0071038 - nuclear polyadenylation-dependent tRNA catabolic process [Evidence IGI] [PMID 18000032]; GO_process: GO:0071049 - nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [Evidence IGI] [PMID 11586364]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0071051 - polyadenylation-dependent snoRNA 3'-end processing [Evidence IMP] [PMID 10611222]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 10508172]; GO_process: GO:0016075 - rRNA catabolic process [Evidence IMP] [PMID 9463390]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]
mitochondrial 54S ribosomal protein YmL19
similar to AA sequence:KEGG_Orthology:K02867
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IDA] [PMID 9151978]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 9151978]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 9151978]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00600
Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 6271]; GO_component: GO:0005739 - mitochondrion [Evidence IMP] [PMID 9398220]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004372 - glycine hydroxymethyltransferase activity [Evidence IMP] [PMID 1100397]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006563 - L-serine metabolic process [Evidence IEA]; GO_process: GO:0006544 - glycine metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IMP] [PMID 1100397]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IGI] [PMID 9398220]; GO_process: GO:0009070 - serine family amino acid biosynthetic process [Evidence IGI] [PMID 9398220]; GO_process: GO:0035999 - tetrahydrofolate interconversion [Evidence IEA]
Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9448009]; GO_component: GO:0000943 - retrotransposon nucleocapsid [Evidence ISS] [PMID 9582191]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003887 - DNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence ISS] [PMID 9582191]; GO_function: GO:0004523 - RNA-DNA hybrid ribonuclease activity [Evidence IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence IEA,IEA]; GO_function: GO:0003964 - RNA-directed DNA polymerase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0004540 - ribonuclease activity [Evidence ISS] [PMID 9582191]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015074 - DNA integration [Evidence IEA,IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IEA]; GO_process: GO:0006261 - DNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0090502 - RNA phosphodiester bond hydrolysis, endonucleolytic [Evidence IEA]; GO_process: GO:0006278 - RNA-dependent DNA replication [Evidence IEA,IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0032196 - transposition [Evidence IEA]; GO_process: GO:0032197 - transposition, RNA-mediated [Evidence ISS] [PMID 9582191]; GO_process: GO:0019076 - viral release from host cell [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17792
Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0042721 - mitochondrial inner membrane protein insertion complex [Evidence IDA] [PMID 10637294]; GO_component: GO:0042721 - mitochondrial inner membrane protein insertion complex [Evidence IDA] [PMID 10648604]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015266 - protein channel activity [Evidence IDA] [PMID 12637749]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IGI] [PMID 10637294]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IMP] [PMID 17893242]; GO_process: GO:0045039 - protein import into mitochondrial inner membrane [Evidence IGI,IMP] [PMID 9412462]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11873
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p, the largest subunit of RNAP I, by mediating its deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 22902402]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10490600]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_function: GO:0008234 - cysteine-type peptidase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0004843 - ubiquitin-specific protease activity [Evidence IDA] [PMID 10490600]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 15721261]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 22829782]; GO_process: GO:0016579 - protein deubiquitination [Evidence IDA,IMP] [PMID 15721261]; GO_process: GO:0016579 - protein deubiquitination [Evidence IMP] [PMID 22829782]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0006511 - ubiquitin-dependent protein catabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14857
AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10556316]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10648622]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10556316]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 11583614]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016435 - rRNA (guanine) methyltransferase activity [Evidence IMP] [PMID 15546625]; GO_function: GO:0008650 - rRNA (uridine-2'-O-)-methyltransferase activity [Evidence IGI] [PMID 14636587]; GO_function: GO:0008649 - rRNA methyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0001510 - RNA methylation [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10556316]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10648622]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10556316]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10648622]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IGI] [PMID 14636587]; GO_process: GO:0031167 - rRNA methylation [Evidence IDA,IGI,IMP] [PMID 15546625]; GO_process: GO:0006364 - rRNA processing [Evidence IEA,IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08738
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 9866716]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 18975895]; GO_function: GO:0009055 - electron carrier activity [Evidence IDA] [PMID 7851399]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen [Evidence IDA] [PMID 7851399]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IDA] [PMID 7851399]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 10409731]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0015171 - amino acid transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0003333 - amino acid transmembrane transport [Evidence IEA]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0043200 - response to amino acid [Evidence IMP] [PMID 10409731]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12870
Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 11018040]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 10094305]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 11018040]; GO_component: GO:0071007 - U2-type catalytic step 2 spliceosome [Evidence IDA] [PMID 10094305]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0071014 - post-mRNA release spliceosomal complex [Evidence IDA] [PMID 10094305]; GO_component: GO:0071020 - post-spliceosomal complex [Evidence IDA] [PMID 10094305]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IGI] [PMID 16103217]; GO_function: GO:0000386 - second spliceosomal transesterification activity [Evidence IC] [PMID 10094305]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0000350 - generation of catalytic spliceosome for second transesterification step [Evidence IMP] [PMID 10094305]; GO_process: GO:0000389 - mRNA 3'-splice site recognition [Evidence IMP] [PMID 16103217]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 9748433]; GO_function: GO:0042973 - glucan endo-1,3-beta-D-glucosidase activity [Evidence ISS] [PMID 9748433]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA]; GO_process: GO:0007109 - cytokinesis, completion of separation [Evidence IMP] [PMID 9748433]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
ubiquinol--cytochrome-c reductase catalytic subunit CYT1
similar to AA sequence:KEGG_Orthology:K00413
Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence TAS] [PMID 11279090]; GO_component: GO:0005746 - mitochondrial respiratory chain [Evidence TAS] [PMID 11279090]; GO_component: GO:0005750 - mitochondrial respiratory chain complex III [Evidence IDA] [PMID 10873857]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0070469 - respiratory chain [Evidence IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0045153 - electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity [Evidence IMP] [PMID 11279090]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c [Evidence IMP] [PMID 11279090]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006119 - oxidative phosphorylation [Evidence TAS] [PMID 11279090]
similar to AA sequence:KEGG_Orthology:K01099
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 17452534]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IDA] [PMID 9560389]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IEA]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA] [PMID 10224048]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IMP] [PMID 9438131]; GO_function: GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [Evidence IDA,IMP] [PMID 9565610]; GO_function: GO:0042578 - phosphoric ester hydrolase activity [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IDA] [PMID 10224048]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9438131]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 9560389]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00784
tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14690591]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 24249226]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 24249226]; GO_function: GO:0042781 - 3'-tRNA processing endoribonuclease activity [Evidence IDA] [PMID 12711671]; GO_function: GO:0042781 - 3'-tRNA processing endoribonuclease activity [Evidence IDA] [PMID 24249226]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_process: GO:1990180 - mitochondrial tRNA 3'-end processing [Evidence IDA,IMP] [PMID 24249226]; GO_process: GO:0042780 - tRNA 3'-end processing [Evidence IDA] [PMID 24249226]; GO_process: GO:0034414 - tRNA 3'-trailer cleavage, endonucleolytic [Evidence IDA] [PMID 12711671]; GO_process: GO:0034414 - tRNA 3'-trailer cleavage, endonucleolytic [Evidence IMP] [PMID 24249226]; GO_process: GO:0008033 - tRNA processing [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14814
Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 11483521]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IGI] [PMID 20016074]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IEA]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006998 - nuclear envelope organization [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IEA]; GO_process: GO:0006611 - protein export from nucleus [Evidence IMP] [PMID 11483521]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14845
Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IPI] [PMID 10805743]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12612077]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0034353 - RNA pyrophosphohydrolase activity [Evidence IDA] [PMID 20802481]; GO_function: GO:0030234 - enzyme regulator activity [Evidence IDA] [PMID 10805743]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:1990174 - phosphodiesterase decapping endonuclease activity [Evidence IDA,IMP] [PMID 20802481]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10805743]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 10805743]; GO_process: GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process [Evidence IMP] [PMID 16131592]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IDA,IMP] [PMID 20802481]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0030846 - termination of RNA polymerase II transcription, poly(A)-coupled [Evidence IMP] [PMID 15565157]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17917
Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9175702]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9175702]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 9700157]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IEA]; GO_component: GO:0030904 - retromer complex [Evidence IMP,IPI] [PMID 9700157]; GO_component: GO:0030905 - retromer complex, outer shell [Evidence IPI] [PMID 9700157]; GO_function: GO:0035091 - phosphatidylinositol binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IEA]; GO_function: GO:0032266 - phosphatidylinositol-3-phosphate binding [Evidence IDA] [PMID 11557775]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9700157]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IPI] [PMID 9700157]; GO_process: GO:0006810 - transport [Evidence IEA]
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; expression is glucose-repressible; GO_component: GO:0031417 - NatC complex [Evidence IDA] [PMID 10504710]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IMP] [PMID 11274203]; GO_process: GO:0006474 - N-terminal protein amino acid acetylation [Evidence IMP] [PMID 11274203]
similar to AA sequence:KEGG_Orthology:K17065
Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 20841380]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA,IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15550248]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 16520372]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA,ISS] [PMID 8299420]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IMP,IPI] [PMID 15265985]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IGI,IMP] [PMID 20841380]; GO_process: GO:0060988 - lipid tube assembly [Evidence IDA] [PMID 20841380]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0016559 - peroxisome fission [Evidence IMP] [PMID 18445678]; GO_process: GO:0007031 - peroxisome organization [Evidence IDA,IGI,IMP] [PMID 12707309]; GO_process: GO:0045053 - protein retention in Golgi apparatus [Evidence IMP] [PMID 8649377]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 8299420]; GO_process: GO:0007034 - vacuolar transport [Evidence IMP] [PMID 8299420]
similar to AA sequence:KEGG_Orthology:K13237
Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0071627 - integral component of fungal-type vacuolar membrane [Evidence IDA] [PMID 23169667]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015326 - cationic amino acid transmembrane transporter activity [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0034488 - basic amino acid transmembrane export from vacuole [Evidence IMP,ISO] [PMID 23169667]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14376
Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping; GO_component: GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex [Evidence IDA] [PMID 12819204]; GO_component: GO:0005654 - nucleoplasm [Evidence IPI] [PMID 8631901]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016779 - nucleotidyltransferase activity [Evidence IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 17850751]; GO_function: GO:0004652 - polynucleotide adenylyltransferase activity [Evidence IDA] [PMID 1840648]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0031123 - RNA 3'-end processing [Evidence IEA]; GO_process: GO:0043631 - RNA polyadenylation [Evidence IEA]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 1840648]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IMP] [PMID 8524265]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0071050 - snoRNA polyadenylation [Evidence IGI] [PMID 18951092]
similar to AA sequence:KEGG_Orthology:K05302
Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IGI,IMP] [PMID 18957409]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IGI,IMP] [PMID 18957409]
similar to AA sequence:KEGG_Orthology:K10752
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8858151]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9575221]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IPI] [PMID 14761951]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA,IPI] [PMID 8858151]; GO_component: GO:0000123 - histone acetyltransferase complex [Evidence IDA] [PMID 9575221]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14761951]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9575221]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IDA,IMP] [PMID 8858151]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 9575221]; GO_function: GO:0042393 - histone binding [Evidence IDA] [PMID 8858151]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IDA] [PMID 8858151]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 10982821]; GO_process: GO:0016573 - histone acetylation [Evidence IDA,IMP] [PMID 8858151]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 9575221]
54S ribosomal protein L50, mitochondrial
Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9852143]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9852143]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP] [PMID 9755161]; GO_function: GO:0008565 - protein transporter activity [Evidence IDA] [PMID 9852143]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP,ISS] [PMID 9755161]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IEA]; GO_function: GO:0016788 - hydrolase activity, acting on ester bonds [Evidence IDA] [PMID 10855721]; GO_process: GO:0006083 - acetate metabolic process [Evidence IDA] [PMID 10855721]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]
ATP-binding cassette Fe/S cluster precursor transporter ATM1
similar to AA sequence:KEGG_Orthology:K05663
Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; GO_component: GO:0016021 - integral component of membrane [Evidence IBA,IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7828591]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 16754360]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IEA]; GO_function: GO:0042626 - ATPase activity, coupled to transmembrane movement of substances [Evidence IMP,ISS] [PMID 7828591]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 9428742]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IBA,IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
aminophospholipid-translocating P4-type ATPase DNF3
Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005802 - trans-Golgi network [Evidence IDA] [PMID 17093059]; GO_component: GO:0030140 - trans-Golgi network transport vesicle [Evidence IDA] [PMID 12221123]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0019829 - cation-transporting ATPase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0000287 - magnesium ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IEA,IEA]; GO_function: GO:0004012 - phospholipid-translocating ATPase activity [Evidence IGI,IMP] [PMID 16452632]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 12221123]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0045332 - phospholipid translocation [Evidence IMP] [PMID 16452632]; GO_process: GO:0015914 - phospholipid transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02885
Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0006412 - translation [Evidence IEA]
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 17897954]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0010181 - FMN binding [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IEA]; GO_function: GO:0003959 - NADPH dehydrogenase activity [Evidence IDA,ISS] [PMID 8454584]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0018548 - pentaerythritol trinitrate reductase activity [Evidence IEA]; GO_function: GO:0052690 - trichloro-p-hydroquinone reductive dehalogenase activity [Evidence IEA]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17897954]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K09448
Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19218425]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 9036858]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 9036858]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IGI,IMP] [PMID 16782869]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0003700 - sequence-specific DNA binding transcription factor activity [Evidence IEA]; GO_process: GO:0001300 - chronological cell aging [Evidence IMP] [PMID 21840851]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 12455687]; GO_process: GO:0036003 - positive regulation of transcription from RNA polymerase II promoter in response to stress [Evidence IDA] [PMID 9036858]; GO_process: GO:0010527 - positive regulation of transposition, RNA-mediated [Evidence IMP] [PMID 10652102]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 8730867]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IDA,IMP] [PMID 9036858]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 9055077]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14980713]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 15356260]; GO_component: GO:0005934 - cellular bud tip [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 15356260]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000282 - cellular bud site selection [Evidence IGI] [PMID 11110666]; GO_process: GO:0038032 - termination of G-protein coupled receptor signaling pathway [Evidence IEA]
RNA polymerase II transcription elongation factor SpELL
Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01426
Putative amidase; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0004040 - amidase activity [Evidence IEA]; GO_function: GO:0004040 - amidase activity [Evidence ISS] [PMID 2263500]; GO_function: GO:0016884 - carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016811 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0008152 - metabolic process [Evidence IEA,IEA,IEA]
similar to AA sequence:KEGG_Orthology:K15289
oxysterol-binding protein related protein OSH3
Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GO_component: GO:0032541 - cortical endoplasmic reticulum [Evidence IDA] [PMID 20008566]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11408574]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_function: GO:0005545 - 1-phosphatidylinositol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_function: GO:0008289 - lipid binding [Evidence IDA] [PMID 20008566]; GO_function: GO:0008142 - oxysterol binding [Evidence ISS] [PMID 11238399]; GO_function: GO:0015248 - sterol transporter activity [Evidence IDA] [PMID 20008566]; GO_process: GO:0035621 - ER to Golgi ceramide transport [Evidence IMP] [PMID 24213531]; GO_process: GO:0006897 - endocytosis [Evidence IGI] [PMID 15173322]; GO_process: GO:0006887 - exocytosis [Evidence IGI] [PMID 17004323]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IGI] [PMID 12054531]; GO_process: GO:0000742 - karyogamy involved in conjugation with cellular fusion [Evidence IGI] [PMID 12054531]; GO_process: GO:0006869 - lipid transport [Evidence IEA]; GO_process: GO:0030011 - maintenance of cell polarity [Evidence IGI] [PMID 17004323]; GO_process: GO:0010922 - positive regulation of phosphatase activity [Evidence IDA] [PMID 21295699]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 12054531]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IMP] [PMID 17082746]; GO_process: GO:0015918 - sterol transport [Evidence IGI,IMP] [PMID 16585271]; GO_process: GO:0015918 - sterol transport [Evidence IDA] [PMID 20008566]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
Vacuolar membrane hypothetical protein; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 10637174]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11743162]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11901111]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0017024 - myosin I binding [Evidence IPI] [PMID 11901111]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI,IPI] [PMID 11901111]
similar to AA sequence:KEGG_Orthology:K00789
S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004478 - methionine adenosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004478 - methionine adenosyltransferase activity [Evidence IDA] [PMID 18078345]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process [Evidence IMP] [PMID 17426150]; GO_process: GO:0006555 - methionine metabolic process [Evidence IMP] [PMID 4585174]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]
bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2
similar to AA sequence:KEGG_Orthology:K14655
Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence ISM] [PMID 15466869]; GO_function: GO:0043723 - 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [Evidence IMP] [PMID 4555411]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0008835 - diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IEA]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence IDA,IMP] [PMID 15466869]; GO_function: GO:0009982 - pseudouridine synthase activity [Evidence ISS] [PMID 8710514]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009451 - RNA modification [Evidence IEA]; GO_process: GO:0001522 - pseudouridine synthesis [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]; GO_process: GO:0031119 - tRNA pseudouridine synthesis [Evidence IDA,IMP] [PMID 15466869]
Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10684247]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 9238021]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005643 - nuclear pore [Evidence IEA,IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 9238021]; GO_function: GO:0008536 - Ran GTPase binding [Evidence IEA]; GO_function: GO:0008139 - nuclear localization sequence binding [Evidence IDA] [PMID 11694505]; GO_function: GO:0008565 - protein transporter activity [Evidence IPI] [PMID 9182759]; GO_function: GO:0008565 - protein transporter activity [Evidence IMP,IPI] [PMID 9321403]; GO_process: GO:0006607 - NLS-bearing protein import into nucleus [Evidence IMP] [PMID 11694505]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0006606 - protein import into nucleus [Evidence IMP] [PMID 11352936]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:2000220 - regulation of pseudohyphal growth [Evidence IMP] [PMID 22043304]; GO_process: GO:0006610 - ribosomal protein import into nucleus [Evidence IMP] [PMID 9321403]; GO_process: GO:0006810 - transport [Evidence IEA]
mitochondrial 54S ribosomal protein YmL2
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0000048 - peptidyltransferase activity [Evidence ISS] [PMID 9445368]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 12649274]; GO_function: GO:0015205 - nucleobase transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_function: GO:0051183 - vitamin transporter activity [Evidence IDA] [PMID 12649274]; GO_process: GO:0015851 - nucleobase transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]; GO_process: GO:0051180 - vitamin transport [Evidence IDA] [PMID 12649274]
bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase
similar to AA sequence:KEGG_Orthology:K01784
UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 14764091]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IEA,IEA]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IMP] [PMID 14158615]; GO_function: GO:0003978 - UDP-glucose 4-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IEA]; GO_function: GO:0004034 - aldose 1-epimerase activity [Evidence IDA] [PMID 14764091]; GO_function: GO:0030246 - carbohydrate binding [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA,IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA,IEA]; GO_process: GO:0005975 - carbohydrate metabolic process [Evidence IEA,IEA]; GO_process: GO:0044237 - cellular metabolic process [Evidence IEA]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IMP] [PMID 14158615]; GO_process: GO:0033499 - galactose catabolic process via UDP-galactose [Evidence IDA] [PMID 14764091]; GO_process: GO:0006012 - galactose metabolic process [Evidence IEA,IEA,IEA]; GO_process: GO:0019318 - hexose metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication; GO_component: GO:0032545 - CURI complex [Evidence IDA] [PMID 17452446]; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 15620355]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 15466158]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 15466158]; GO_function: GO:0003713 - transcription coactivator activity [Evidence IGI,IMP] [PMID 15620355]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 9755194]; GO_process: GO:0060963 - positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter [Evidence IMP] [PMID 15616569]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03249
similar to AA sequence:KEGG_Orthology:K16196
similar to Aspergillus flavus NRRL3357 XP_002376764.1
similar to AA sequence:KEGG_Orthology:K14813
Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 12374754]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 16648468]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 16648468]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16648468]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 12374754]; GO_component: GO:0005654 - nucleoplasm [Evidence IDA] [PMID 16648468]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 16648468]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0006508 - proteolysis [Evidence IEA]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16648468]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI] [PMID 17803941]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IGI,IMP] [PMID 18077551]
similar to AA sequence:KEGG_Orthology:K11365
SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; relocalizes to the cytosol in response to hypoxia; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; GO_component: GO:0071819 - DUBm complex [Evidence IDA] [PMID 20395473]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 12052880]; GO_component: GO:0000124 - SAGA complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0000124 - SAGA complex [Evidence IDA] [PMID 17090597]; GO_component: GO:0046695 - SLIK (SAGA-like) complex [Evidence IPI] [PMID 15932941]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0008047 - enzyme activator activity [Evidence IDA] [PMID 18488019]; GO_function: GO:0008047 - enzyme activator activity [Evidence IMP] [PMID 20434206]; GO_function: GO:0004402 - histone acetyltransferase activity [Evidence IMP] [PMID 15932941]; GO_function: GO:0005198 - structural molecule activity [Evidence IGI,IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 15932941]; GO_process: GO:0016568 - chromatin modification [Evidence IMP] [PMID 17090597]; GO_process: GO:0016573 - histone acetylation [Evidence IPI] [PMID 12052880]; GO_process: GO:0016573 - histone acetylation [Evidence IMP] [PMID 15932941]; GO_process: GO:0016578 - histone deubiquitination [Evidence IMP] [PMID 19226466]; GO_process: GO:0006406 - mRNA export from nucleus [Evidence IMP] [PMID 18488019]; GO_process: GO:0045899 - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [Evidence IMP] [PMID 17090597]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 19226466]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06630
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; BMH2 has a paralog, BMH1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12167636]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 12167636]; GO_function: GO:0050815 - phosphoserine binding [Evidence IMP] [PMID 9822578]; GO_function: GO:0019904 - protein domain specific binding [Evidence IEA]; GO_process: GO:0000077 - DNA damage checkpoint [Evidence IMP] [PMID 14704161]; GO_process: GO:0006270 - DNA replication initiation [Evidence IGI] [PMID 19934224]; GO_process: GO:0007265 - Ras protein signal transduction [Evidence IGI] [PMID 9215628]; GO_process: GO:0030437 - ascospore formation [Evidence IGI] [PMID 9215628]; GO_process: GO:0034221 - fungal-type cell wall chitin biosynthetic process [Evidence IGI] [PMID 17559233]; GO_process: GO:0005977 - glycogen metabolic process [Evidence IGI] [PMID 9215628]; GO_process: GO:0043066 - negative regulation of apoptotic process [Evidence IMP] [PMID 22785534]; GO_process: GO:0051436 - negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [Evidence IPI] [PMID 17030612]; GO_process: GO:0006267 - pre-replicative complex assembly involved in nuclear cell cycle DNA replication [Evidence IGI] [PMID 19934224]; GO_process: GO:0007124 - pseudohyphal growth [Evidence IGI] [PMID 9215628]; GO_process: GO:0001402 - signal transduction involved in filamentous growth [Evidence IGI] [PMID 9215628]
guanine nucleotide-binding protein subunit beta
similar to AA sequence:KEGG_Orthology:K12857
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 15340087]; GO_function: GO:0001965 - G-protein alpha-subunit binding [Evidence IPI] [PMID 17591772]; GO_function: GO:0005092 - GDP-dissociation inhibitor activity [Evidence IDA] [PMID 17591772]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0010255 - glucose mediated signaling pathway [Evidence IMP,IPI] [PMID 17591772]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 17591772]; GO_process: GO:0017148 - negative regulation of translation [Evidence IMP] [PMID 15340087]
top hit is XP_002839470.1 originated in Tuber melanosporum Mel28
similar to AA sequence:KEGG_Orthology:K14002
One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IEA]; GO_component: GO:0005788 - endoplasmic reticulum lumen [Evidence IDA] [PMID 7744969]; GO_function: GO:0051087 - chaperone binding [Evidence IMP,ISS] [PMID 9817751]; GO_function: GO:0031072 - heat shock protein binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 11381090]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0034975 - protein folding in endoplasmic reticulum [Evidence IMP] [PMID 9817751]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006986 - response to unfolded protein [Evidence IMP] [PMID 9817751]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00507
Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 12475963]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0009055 - electron carrier activity [Evidence IGI,ISA] [PMID 8530368]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0016717 - oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Evidence IEA]; GO_function: GO:0004768 - stearoyl-CoA 9-desaturase activity [Evidence IEA,IEA]; GO_function: GO:0004768 - stearoyl-CoA 9-desaturase activity [Evidence IMP,ISS] [PMID 1978720]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA,IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006636 - unsaturated fatty acid biosynthetic process [Evidence IMP,ISS] [PMID 1978720]
bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8
similar to AA sequence:KEGG_Orthology:K02304
Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004325 - ferrochelatase activity [Evidence IDA] [PMID 11980703]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IDA] [PMID 10051442]; GO_function: GO:0043115 - precorrin-2 dehydrogenase activity [Evidence IDA] [PMID 11980703]; GO_function: GO:0051266 - sirohydrochlorin ferrochelatase activity [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006779 - porphyrin-containing compound biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0019354 - siroheme biosynthetic process [Evidence IMP] [PMID 9003798]; GO_process: GO:0000103 - sulfate assimilation [Evidence IMP] [PMID 10051442]
Essential protein required for the accumulation of box C/D snoRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14690591]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence NAS] [PMID 12837249]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0016074 - snoRNA metabolic process [Evidence IMP] [PMID 12837249]
hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 10511544]
similar to AA sequence:KEGG_Orthology:K02838
Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 12853640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003747 - translation release factor activity [Evidence ISO] [PMID 9746366]; GO_process: GO:0032543 - mitochondrial translation [Evidence IMP] [PMID 12853640]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02866
Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 18824477]; GO_process: GO:0000027 - ribosomal large subunit assembly [Evidence IMP] [PMID 9580698]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006415 - translational termination [Evidence IMP] [PMID 18824477]
hypothetical protein; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K12471
Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication; GO_component: GO:0030479 - actin cortical patch [Evidence TAS] [PMID 10652251]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0030276 - clathrin binding [Evidence TAS] [PMID 12461563]; GO_function: GO:0008289 - lipid binding [Evidence IEA]; GO_process: GO:0000147 - actin cortical patch assembly [Evidence IMP] [PMID 10449404]; GO_process: GO:0007015 - actin filament organization [Evidence IMP] [PMID 10449404]; GO_process: GO:0006897 - endocytosis [Evidence IEA]; GO_process: GO:0006897 - endocytosis [Evidence IMP] [PMID 10449404]
similar to AA sequence:KEGG_Orthology:K08257
Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA] [PMID 12421307]; GO_component: GO:0005933 - cellular bud [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0016798 - hydrolase activity, acting on glycosyl bonds [Evidence IEA]; GO_function: GO:0008496 - mannan endo-1,6-alpha-mannosidase activity [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI] [PMID 15470258]; GO_process: GO:0016052 - carbohydrate catabolic process [Evidence IEA]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IDA] [PMID 12421307]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00762
Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IMP] [PMID 4550660]; GO_function: GO:0004588 - orotate phosphoribosyltransferase activity [Evidence IDA] [PMID 9882434]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0044205 - 'de novo' UMP biosynthetic process [Evidence IEA]; GO_process: GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0009116 - nucleoside metabolic process [Evidence IEA]; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0046132 - pyrimidine ribonucleoside biosynthetic process [Evidence IMP] [PMID 4550660]; GO_process: GO:0046132 - pyrimidine ribonucleoside biosynthetic process [Evidence IDA] [PMID 9882434]
acetylglucosaminyltransferase (predicted)
similar to AA sequence:KEGG_Orthology:K03105
Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0048500 - signal recognition particle [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IEA]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IDA] [PMID 1313947]; GO_component: GO:0005786 - signal recognition particle, endoplasmic reticulum targeting [Evidence IMP,ISS] [PMID 1313948]; GO_function: GO:0008312 - 7S RNA binding [Evidence IEA]; GO_function: GO:0008312 - 7S RNA binding [Evidence IDA] [PMID 14681587]; GO_process: GO:0006614 - SRP-dependent cotranslational protein targeting to membrane [Evidence IEA]; GO_process: GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [Evidence IMP] [PMID 1313947]; GO_process: GO:0045047 - protein targeting to ER [Evidence IMP] [PMID 1313948]
similar to AA sequence:KEGG_Orthology:K19703
Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 9353282]; GO_function: GO:0080132 - fatty acid alpha-hydroxylase activity [Evidence IMP] [PMID 9353282]; GO_function: GO:0080132 - fatty acid alpha-hydroxylase activity [Evidence IMP] [PMID 9559540]; GO_function: GO:0020037 - heme binding [Evidence IEA]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 16652392]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 9353282]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IMP] [PMID 9368039]; GO_process: GO:0006673 - inositolphosphoceramide metabolic process [Evidence IGI,IMP] [PMID 9559540]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
Ornithine transporter of the mitochondrial inner membrane
NADH-ubiquinone oxidoreductase subunit, mitochondrial precursor
similar to AA sequence:KEGG_Orthology:K03935
putative mitochondrial Complex I, 17.2 kd subunit
potential mitochondrial NADH-ubiquinone oxidoreductase complex I,17.2 kD subunit; similar to N. crassa orf (CAD21387); allele of CaO19.1625
similar to AA sequence:KEGG_Orthology:K00809
Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0034038 - deoxyhypusine synthase activity [Evidence IEA]; GO_function: GO:0034038 - deoxyhypusine synthase activity [Evidence IDA] [PMID 7629166]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0050983 - deoxyhypusine biosynthetic process from spermidine [Evidence IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IEA,IEA]; GO_process: GO:0008612 - peptidyl-lysine modification to peptidyl-hypusine [Evidence IDA] [PMID 7629166]
similar to AA sequence:KEGG_Orthology:K00939
Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 2850178]; GO_component: GO:0005829 - cytosol [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IEA]; GO_component: GO:0005758 - mitochondrial intermembrane space [Evidence IDA] [PMID 2850178]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IEA,IEA]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA] [PMID 15753074]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IDA,IMP] [PMID 18433446]; GO_function: GO:0004017 - adenylate kinase activity [Evidence IMP] [PMID 2850178]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0019205 - nucleobase-containing compound kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016776 - phosphotransferase activity, phosphate group as acceptor [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006172 - ADP biosynthetic process [Evidence IEA]; GO_process: GO:0006172 - ADP biosynthetic process [Evidence IDA] [PMID 2848829]; GO_process: GO:0006270 - DNA replication initiation [Evidence IMP] [PMID 20980819]; GO_process: GO:0006139 - nucleobase-containing compound metabolic process [Evidence IEA]; GO_process: GO:0009117 - nucleotide metabolic process [Evidence IMP] [PMID 2850178]; GO_process: GO:0046939 - nucleotide phosphorylation [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14400
mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005849 - mRNA cleavage factor complex [Evidence IPI] [PMID 11344258]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IDA] [PMID 12727883]; GO_function: GO:0000993 - RNA polymerase II core binding [Evidence IMP,IPI] [PMID 15998810]; GO_function: GO:0003729 - mRNA binding [Evidence IDA,IMP] [PMID 15998810]; GO_process: GO:0006353 - DNA-templated transcription, termination [Evidence IEA]; GO_process: GO:0006379 - mRNA cleavage [Evidence IDA] [PMID 11344258]; GO_process: GO:0006378 - mRNA polyadenylation [Evidence IDA] [PMID 11344258]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IDA] [PMID 12727883]; GO_process: GO:0006369 - termination of RNA polymerase II transcription [Evidence IDA,IMP] [PMID 15998810]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence ISS] [PMID 10930523]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0001409 - guanine nucleotide transmembrane transporter activity [Evidence IDA] [PMID 14998997]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IMP] [PMID 14629196]; GO_process: GO:0001408 - guanine nucleotide transport [Evidence IDA] [PMID 14998997]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IMP] [PMID 14998997]; GO_process: GO:0000002 - mitochondrial genome maintenance [Evidence IGI] [PMID 8905928]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 14998997]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K12663
hypothetical protein; has an apparent role in acetylation of N-terminal methionine residues; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0004596 - peptide alpha-N-acetyltransferase activity [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016746 - transferase activity, transferring acyl groups [Evidence IEA]; GO_process: GO:0017196 - N-terminal peptidyl-methionine acetylation [Evidence IMP] [PMID 8175741]
similar to AA sequence:KEGG_Orthology:K16185
Cytoplasmic GTPase; forms a heterodimer with Gtr2p to stimulate TORC1 in response to amino acids; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB; GO_component: GO:0034448 - EGO complex [Evidence IDA] [PMID 16732272]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 10388807]; GO_component: GO:1990131 - Gtr1-Gtr2 GTPase complex [Evidence IPI] [PMID 16143306]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10388807]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 15885099]; GO_component: GO:0031902 - late endosome membrane [Evidence IDA] [PMID 16732272]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10388807]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 22726655]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 23716719]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006184 - GTP catabolic process [Evidence IDA] [PMID 22726655]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 18258182]; GO_process: GO:0006817 - phosphate ion transport [Evidence IEA]; GO_process: GO:0006817 - phosphate ion transport [Evidence IMP] [PMID 1620108]; GO_process: GO:0032008 - positive regulation of TOR signaling [Evidence IDA,IGI,IMP] [PMID 19748353]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006360 - transcription from RNA polymerase I promoter [Evidence IMP,IPI] [PMID 15937128]; GO_process: GO:0006383 - transcription from RNA polymerase III promoter [Evidence IMP,IPI] [PMID 15937128]; GO_process: GO:0006810 - transport [Evidence IEA]
bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
similar to AA sequence:KEGG_Orthology:K00801
Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 350878]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IDA] [PMID 8157649]; GO_function: GO:0004310 - farnesyl-diphosphate farnesyltransferase activity [Evidence IDA] [PMID 8323279]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0051996 - squalene synthase activity [Evidence IEA]; GO_function: GO:0051996 - squalene synthase activity [Evidence IDA] [PMID 8157649]; GO_function: GO:0051996 - squalene synthase activity [Evidence IDA] [PMID 8323279]; GO_function: GO:0016740 - transferase activity [Evidence IEA,IEA]; GO_function: GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 1807826]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IMP] [PMID 200835]; GO_process: GO:0008299 - isoprenoid biosynthetic process [Evidence IEA]; GO_process: GO:0008610 - lipid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18586
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; GO_component: GO:0031314 - extrinsic component of mitochondrial inner membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 11469793]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IEA,IEA,IEA,IEA]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 11469793]; GO_process: GO:0006744 - ubiquinone biosynthetic process [Evidence IMP] [PMID 9266513]
similar to AA sequence:KEGG_Orthology:K14564
Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IPI] [PMID 10733567]; GO_component: GO:0031428 - box C/D snoRNP complex [Evidence IDA] [PMID 11081632]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 9372940]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_process: GO:0000154 - rRNA modification [Evidence TAS] [PMID 10690410]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 10733567]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01265
Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IEA]; GO_component: GO:0022626 - cytosolic ribosome [Evidence IDA] [PMID 11968008]; GO_function: GO:0004177 - aminopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IEA]; GO_function: GO:0070006 - metalloaminopeptidase activity [Evidence IDA] [PMID 2246265]; GO_function: GO:0008235 - metalloexopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0010629 - negative regulation of gene expression [Evidence IMP] [PMID 21124907]; GO_process: GO:0070084 - protein initiator methionine removal [Evidence IEA]; GO_process: GO:0035551 - protein initiator methionine removal involved in protein maturation [Evidence IMP] [PMID 11811952]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K09498
Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IPI] [PMID 15704212]; GO_component: GO:0005832 - chaperonin-containing T-complex [Evidence IDA] [PMID 16762366]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 16762366]; GO_process: GO:0044267 - cellular protein metabolic process [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0006457 - protein folding [Evidence IDA] [PMID 16762366]
translin-associated factor TraX, putative
similar to AA sequence:KEGG_Orthology:K09245
Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19159085]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0000978 - RNA polymerase II core promoter proximal region sequence-specific DNA binding [Evidence IDA] [PMID 12235130]; GO_function: GO:0001077 - RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [Evidence IDA] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0001010 - sequence-specific DNA binding transcription factor recruiting transcription factor activity [Evidence IDA,IGI] [PMID 21515579]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:0019740 - nitrogen utilization [Evidence IMP] [PMID 7899074]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex; GO_component: GO:0030134 - ER to Golgi transport vesicle [Evidence IDA] [PMID 10747087]; GO_component: GO:0000139 - Golgi membrane [Evidence IDA] [PMID 15372079]; GO_component: GO:0031201 - SNARE complex [Evidence IDA] [PMID 15372079]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10747087]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IGI] [PMID 15958490]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0000149 - SNARE binding [Evidence IDA] [PMID 15958490]; GO_function: GO:0019905 - syntaxin binding [Evidence IDA,IMP] [PMID 12186954]; GO_function: GO:0019905 - syntaxin binding [Evidence IDA] [PMID 15372079]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 9545229]; GO_process: GO:0035543 - positive regulation of SNARE complex assembly [Evidence IMP] [PMID 12186954]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 15958490]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006904 - vesicle docking involved in exocytosis [Evidence IEA]; GO_process: GO:0048280 - vesicle fusion with Golgi apparatus [Evidence IMP] [PMID 8636207]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
RuvB family ATP-dependent DNA helicase pontin
similar to AA sequence:KEGG_Orthology:K04499
ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; GO_component: GO:0070209 - ASTRA complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 10952318]; GO_component: GO:0031011 - Ino80 complex [Evidence IPI] [PMID 24034245]; GO_component: GO:0097255 - R2TP complex [Evidence IDA] [PMID 15766533]; GO_component: GO:0097255 - R2TP complex [Evidence IPI] [PMID 18268103]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14645854]; GO_component: GO:0000812 - Swr1 complex [Evidence IPI] [PMID 14690608]; GO_component: GO:0000812 - Swr1 complex [Evidence IDA] [PMID 16299513]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0043140 - ATP-dependent 3'-5' DNA helicase activity [Evidence IDA] [PMID 10952318]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IEA]; GO_function: GO:0043141 - ATP-dependent 5'-3' DNA helicase activity [Evidence IDA] [PMID 18234224]; GO_function: GO:0003678 - DNA helicase activity [Evidence IEA]; GO_function: GO:0004386 - helicase activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0032508 - DNA duplex unwinding [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006338 - chromatin remodeling [Evidence IPI] [PMID 14690608]; GO_process: GO:0043486 - histone exchange [Evidence IPI] [PMID 14645854]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 11278922]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11121
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence ISS] [PMID 7498786]; GO_function: GO:0070403 - NAD+ binding [Evidence IEA]; GO_function: GO:0004407 - histone deacetylase activity [Evidence IMP] [PMID 16815704]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IGI] [PMID 7498786]; GO_process: GO:0016575 - histone deacetylation [Evidence IMP] [PMID 16815704]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0046459 - short-chain fatty acid metabolic process [Evidence IMP] [PMID 12618394]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K06883
Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0005525 - GTP binding [Evidence ISA] [PMID 23267056]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0005048 - signal sequence binding [Evidence ISS] [PMID 14690591]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP] [PMID 23267056]; GO_process: GO:1990022 - RNA polymerase III complex localization to nucleus [Evidence IMP] [PMID 23267056]
similar to AA sequence:KEGG_Orthology:K14692
Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 15277543]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 11058603]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031965 - nuclear membrane [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0046873 - metal ion transmembrane transporter activity [Evidence ISS] [PMID 11058603]; GO_function: GO:0005385 - zinc ion transmembrane transporter activity [Evidence IMP] [PMID 11058603]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006882 - cellular zinc ion homeostasis [Evidence IMP] [PMID 11058603]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 15277543]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IEA]; GO_process: GO:0006829 - zinc ion transport [Evidence IMP] [PMID 15277543]
Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 19451230]; GO_component: GO:0030532 - small nuclear ribonucleoprotein complex [Evidence IDA] [PMID 19451230]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 19451230]
similar to AA sequence:KEGG_Orthology:K09613
Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; GO_component: GO:0008180 - COP9 signalosome [Evidence IEA]; GO_component: GO:0008180 - COP9 signalosome [Evidence IDA] [PMID 12446563]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IMP] [PMID 12183637]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0000754 - adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Evidence IMP] [PMID 12446563]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 12186635]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 12446563]; GO_process: GO:0010388 - cullin deneddylation [Evidence IMP] [PMID 24164706]; GO_process: GO:0070452 - positive regulation of ergosterol biosynthetic process [Evidence IMP] [PMID 24164706]; GO_process: GO:0006508 - proteolysis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18469
similar to AA sequence:KEGG_Orthology:K07541
Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 9649520]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence IMP] [PMID 15635094]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 16418276]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006506 - GPI anchor biosynthetic process [Evidence IMP] [PMID 15635094]; GO_process: GO:0016485 - protein processing [Evidence IMP] [PMID 9649520]
GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 22842922]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 22842922]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA]; GO_function: GO:0005100 - Rho GTPase activator activity [Evidence IDA] [PMID 11591390]; GO_process: GO:0035556 - intracellular signal transduction [Evidence IEA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IC,IPI] [PMID 11591390]
Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0006357 - regulation of transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K01497
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005525 - GTP binding [Evidence IEA]; GO_function: GO:0003935 - GTP cyclohydrolase II activity [Evidence IEA,IEA]; GO_function: GO:0019238 - cyclohydrolase activity [Evidence IGI,IMP] [PMID 4555411]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 4555411]; GO_process: GO:0009231 - riboflavin biosynthetic process [Evidence IMP] [PMID 5366000]
similar to AA sequence:KEGG_Orthology:K17868
Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 21880895]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 21880895]; GO_function: GO:0032451 - demethylase activity [Evidence IDA,IMP] [PMID 24739148]; GO_process: GO:0032456 - endocytic recycling [Evidence IMP] [PMID 21880895]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IEA]; GO_process: GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine [Evidence IMP] [PMID 22188241]
Molybdenum cofactor biosynthesis protein A
similar to AA sequence:KEGG_Orthology:K03639
Molybdenum cofactor biosynthesis protein C
one of two genes similar to Amanita muscaria DOPA-dioxygenase; allele of CaO19.8608
similar to AA sequence:KEGG_Orthology:K06965
Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0004519 - endonuclease activity [Evidence IEA]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 17889667]; GO_function: GO:0004521 - endoribonuclease activity [Evidence IDA] [PMID 19420139]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004518 - nuclease activity [Evidence IEA]; GO_function: GO:0043022 - ribosome binding [Evidence IDA] [PMID 21623367]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0070651 - nonfunctional rRNA decay [Evidence IMP] [PMID 19481524]; GO_process: GO:0000294 - nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [Evidence IDA] [PMID 17889667]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IGI] [PMID 16554824]; GO_process: GO:0070966 - nuclear-transcribed mRNA catabolic process, no-go decay [Evidence IMP] [PMID 19420139]; GO_process: GO:0090305 - nucleic acid phosphodiester bond hydrolysis [Evidence IEA]; GO_process: GO:0045727 - positive regulation of translation [Evidence IMP] [PMID 24424461]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA] [PMID 20947765]; GO_process: GO:0032790 - ribosome disassembly [Evidence IMP] [PMID 22770215]; GO_process: GO:0032790 - ribosome disassembly [Evidence IDA,IMP] [PMID 24424461]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K08139
Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 2406560]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 24124599]; GO_function: GO:0005536 - glucose binding [Evidence TAS] [PMID 10477308]; GO_function: GO:0005355 - glucose transmembrane transporter activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0004872 - receptor activity [Evidence TAS] [PMID 10477308]; GO_function: GO:0022891 - substrate-specific transmembrane transporter activity [Evidence IEA]; GO_function: GO:0022857 - transmembrane transporter activity [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0008643 - carbohydrate transport [Evidence IEA]; GO_process: GO:0051594 - detection of glucose [Evidence IGI,IMP] [PMID 8901598]; GO_process: GO:0015755 - fructose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0015758 - glucose transport [Evidence IGI] [PMID 9564039]; GO_process: GO:0015761 - mannose transport [Evidence IMP] [PMID 2046678]; GO_process: GO:0045835 - negative regulation of meiosis [Evidence IMP] [PMID 18616605]; GO_process: GO:0007165 - signal transduction [Evidence TAS] [PMID 10477308]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
ubiquinone biosynthesis protein Coq9 (predicted)
similar to AA sequence:KEGG_Orthology:K18587
Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 12514182]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 23625923]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0000321 - re-entry into mitotic cell cycle after pheromone arrest [Evidence IGI] [PMID 12588993]
Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA; GO_component: GO:0031942 - i-AAA complex [Evidence IDA] [PMID 18843051]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 18843051]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051787 - misfolded protein binding [Evidence IDA] [PMID 18843051]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 18843051]
similar to AA sequence:KEGG_Orthology:K01930
Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0008841 - dihydrofolate synthase activity [Evidence IEA]; GO_function: GO:0008841 - dihydrofolate synthase activity [Evidence IMP] [PMID 11731153]; GO_function: GO:0016874 - ligase activity [Evidence IEA,IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004326 - tetrahydrofolylpolyglutamate synthase activity [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006761 - dihydrofolate biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IEA]; GO_process: GO:0009396 - folic acid-containing compound biosynthetic process [Evidence IMP] [PMID 11731153]; GO_process: GO:0006730 - one-carbon metabolic process [Evidence IEA]; GO_process: GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10908
similar to Saccharomyces cerevisiae S288c NP_116617.1
similar to AA sequence:KEGG_Orthology:K10245
Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0016020 - membrane [Evidence ISS] [PMID 8702485]; GO_function: GO:0009922 - fatty acid elongase activity [Evidence IMP] [PMID 12684876]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0019368 - fatty acid elongation, unsaturated fatty acid [Evidence IMP] [PMID 10850979]; GO_process: GO:0006631 - fatty acid metabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03439
Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0043527 - tRNA methyltransferase complex [Evidence IDA] [PMID 12403464]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IEA,IEA,IEA]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IMP] [PMID 12403464]; GO_function: GO:0008176 - tRNA (guanine-N7-)-methyltransferase activity [Evidence IDA] [PMID 17382321]; GO_function: GO:0000049 - tRNA binding [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0036265 - RNA (guanine-N7)-methylation [Evidence IEA,IEA,IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IEA]; GO_process: GO:0030488 - tRNA methylation [Evidence IMP] [PMID 12403464]; GO_process: GO:0030488 - tRNA methylation [Evidence IDA] [PMID 17382321]; GO_process: GO:0006400 - tRNA modification [Evidence IEA]; GO_process: GO:0008033 - tRNA processing [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K01293
Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions; GO_component: GO:0000328 - fungal-type vacuole lumen [Evidence IDA] [PMID 1569061]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IEA]; GO_function: GO:0004180 - carboxypeptidase activity [Evidence IMP] [PMID 2026161]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA,IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004181 - metallocarboxypeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006807 - nitrogen compound metabolic process [Evidence IMP] [PMID 2026161]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0051603 - proteolysis involved in cellular protein catabolic process [Evidence IMP] [PMID 2026161]
similar to AA sequence:KEGG_Orthology:K06123
Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10617610]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005811 - lipid particle [Evidence IEA,IEA]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 10617610]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IEA]; GO_function: GO:0000140 - acylglycerone-phosphate reductase activity [Evidence IMP] [PMID 10617610]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0004806 - triglyceride lipase activity [Evidence IDA,IGI,IMP] [PMID 24187129]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]; GO_process: GO:0006654 - phosphatidic acid biosynthetic process [Evidence IMP] [PMID 10617610]; GO_process: GO:0019433 - triglyceride catabolic process [Evidence IGI] [PMID 24187129]
similar to AA sequence:KEGG_Orthology:K18203
Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0018423 - protein C-terminal leucine carboxyl O-methyltransferase activity [Evidence IMP] [PMID 11060018]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006481 - C-terminal protein methylation [Evidence IMP] [PMID 11060018]; GO_process: GO:0043623 - cellular protein complex assembly [Evidence IMP] [PMID 11060018]; GO_process: GO:0032259 - methylation [Evidence IEA,IEA]; GO_process: GO:0010506 - regulation of autophagy [Evidence IMP] [PMID 23870128]
similar to AA sequence:KEGG_Orthology:K14005
Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance; GO_component: GO:0030127 - COPII vesicle coat [Evidence IDA] [PMID 8004676]; GO_component: GO:0012507 - ER to Golgi transport vesicle membrane [Evidence IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0005198 - structural molecule activity [Evidence IDA] [PMID 17604721]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IMP] [PMID 12475940]; GO_process: GO:0090114 - COPII-coated vesicle budding [Evidence IDA] [PMID 8223424]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA]
mitogen-activated serine/threonine-protein kinase SLT2
similar to AA sequence:KEGG_Orthology:K04464
Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 12361575]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 23924898]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 23924898]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 12361575]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 23924898]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence ISS] [PMID 8386319]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 20823268]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IDA] [PMID 24554767]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0030969 - UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response [Evidence IMP] [PMID 18971375]; GO_process: GO:0000917 - barrier septum assembly [Evidence IGI] [PMID 19633265]; GO_process: GO:0030968 - endoplasmic reticulum unfolded protein response [Evidence IDA,IMP] [PMID 16380504]; GO_process: GO:0009272 - fungal-type cell wall biogenesis [Evidence IGI] [PMID 16524906]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 14703512]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IMP] [PMID 20219973]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IGI,IMP] [PMID 8386319]; GO_process: GO:0042990 - regulation of transcription factor import into nucleus [Evidence IMP] [PMID 20219973]; GO_process: GO:0001101 - response to acid [Evidence IMP] [PMID 16087742]; GO_process: GO:0007165 - signal transduction [Evidence IMP] [PMID 8386319]
similar to AA sequence:KEGG_Orthology:K01850
Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0004106 - chorismate mutase activity [Evidence IEA,IEA]; GO_function: GO:0004106 - chorismate mutase activity [Evidence IDA] [PMID 3027508]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_process: GO:0009094 - L-phenylalanine biosynthetic process [Evidence IC,IMP] [PMID 3027508]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0046417 - chorismate metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IC,IMP] [PMID 3027508]
similar to AA sequence:KEGG_Orthology:K15109
Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 23509072]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16140254]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005342 - organic acid transmembrane transporter activity [Evidence IGI,ISS] [PMID 16140254]; GO_process: GO:0006839 - mitochondrial transport [Evidence IGI] [PMID 16140254]; GO_process: GO:0006810 - transport [Evidence IEA]
glucose-induced degradation complex subunit VID24
GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 16872538]; GO_component: GO:0034657 - GID complex [Evidence IDA] [PMID 18508925]; GO_component: GO:0016023 - cytoplasmic membrane-bounded vesicle [Evidence IDA] [PMID 9508768]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0030659 - cytoplasmic vesicle membrane [Evidence IEA]; GO_component: GO:0019898 - extrinsic component of membrane [Evidence IDA] [PMID 9508768]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0045721 - negative regulation of gluconeogenesis [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 12686616]; GO_process: GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 12730205]; GO_process: GO:0006623 - protein targeting to vacuole [Evidence IMP] [PMID 9508768]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 15358789]; GO_process: GO:0007039 - vacuolar protein catabolic process [Evidence IMP] [PMID 9508768]
similar to AA sequence:KEGG_Orthology:K00102
D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 9525904]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11502169]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IEA]; GO_function: GO:0004458 - D-lactate dehydrogenase (cytochrome) activity [Evidence IMP,ISS] [PMID 8492799]; GO_function: GO:0008762 - UDP-N-acetylmuramate dehydrogenase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0050660 - flavin adenine dinucleotide binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors [Evidence IEA]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 8492799]; GO_process: GO:0044262 - cellular carbohydrate metabolic process [Evidence IMP] [PMID 8492799]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K07750
C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 8663358]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8663358]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IEA]; GO_function: GO:0000254 - C-4 methylsterol oxidase activity [Evidence IDA] [PMID 8663358]; GO_function: GO:0005506 - iron ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_process: GO:0006696 - ergosterol biosynthetic process [Evidence IDA] [PMID 8663358]; GO_process: GO:0006633 - fatty acid biosynthetic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006694 - steroid biosynthetic process [Evidence IEA]; GO_process: GO:0008202 - steroid metabolic process [Evidence IEA]; GO_process: GO:0016126 - sterol biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03165
DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity stimulated by RPA and Sgs1p-Top2p-Rmi1p; involved in telomere stability and regulation of mitotic recombination; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IPI] [PMID 15889139]; GO_component: GO:0031422 - RecQ helicase-Topo III complex [Evidence IDA] [PMID 15899853]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 1324925]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IDA] [PMID 22885009]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IEA,IEA]; GO_function: GO:0003917 - DNA topoisomerase type I activity [Evidence IDA] [PMID 1324925]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 22885009]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IMP] [PMID 17571075]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IGI,IMP] [PMID 1328869]; GO_process: GO:0000018 - regulation of DNA recombination [Evidence IMP] [PMID 1328869]; GO_process: GO:0007004 - telomere maintenance via telomerase [Evidence IMP] [PMID 7708702]
D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IEA]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17869212]; GO_function: GO:0008721 - D-serine ammonia-lyase activity [Evidence IDA] [PMID 17937657]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_process: GO:0070178 - D-serine metabolic process [Evidence IMP] [PMID 17937657]
lysine methyltransferase Set8 (predicted)
similar to AA sequence:KEGG_Orthology:K03245
eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for processing of 20S pre-rRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA,IEA]; GO_component: GO:0016282 - eukaryotic 43S preinitiation complex [Evidence IEA]; GO_component: GO:0033290 - eukaryotic 48S preinitiation complex [Evidence IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IEA,IEA]; GO_component: GO:0005852 - eukaryotic translation initiation factor 3 complex [Evidence IPI] [PMID 11179233]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IEA,IEA,IEA]; GO_function: GO:0003743 - translation initiation factor activity [Evidence IPI,ISS] [PMID 11179233]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IPI,ISS] [PMID 11179233]; GO_process: GO:0001731 - formation of translation preinitiation complex [Evidence IEA]; GO_process: GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 11560931]; GO_process: GO:0006446 - regulation of translational initiation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006413 - translational initiation [Evidence IEA,IEA]
mRNA cleavage and polyadenylation specificity factor complex associated protein
similar to AA sequence:KEGG_Orthology:K17679
Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 2535893]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence IDA] [PMID 17081564]; GO_function: GO:0008026 - ATP-dependent helicase activity [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 17081564]; GO_function: GO:0033592 - RNA strand annealing activity [Evidence IDA] [PMID 17081564]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0000372 - Group I intron splicing [Evidence IMP] [PMID 15618406]; GO_process: GO:0000373 - Group II intron splicing [Evidence IMP] [PMID 15618406]; GO_process: GO:0000373 - Group II intron splicing [Evidence IDA] [PMID 17081564]; GO_process: GO:0034337 - RNA folding [Evidence IMP] [PMID 21045551]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0006417 - regulation of translation [Evidence IEA]; GO_process: GO:0006392 - transcription elongation from mitochondrial promoter [Evidence IDA,IMP] [PMID 24732805]
Putative RNA binding hypothetical protein; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0010494 - cytoplasmic stress granule [Evidence IDA] [PMID 18981231]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K00914
Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 16421251]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 16421251]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 19001347]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005643 - nuclear pore [Evidence IDA] [PMID 23335340]; GO_component: GO:0071561 - nucleus-vacuole junction [Evidence IDA] [PMID 23335340]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 21121900]; GO_component: GO:0034271 - phosphatidylinositol 3-kinase complex I [Evidence IDA] [PMID 11157979]; GO_component: GO:0034272 - phosphatidylinositol 3-kinase complex II [Evidence IDA] [PMID 11157979]; GO_component: GO:0000407 - pre-autophagosomal structure [Evidence IDA] [PMID 16421251]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IEA,IEA]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IDA] [PMID 7989323]; GO_function: GO:0016303 - 1-phosphatidylinositol-3-kinase activity [Evidence IDA,IMP] [PMID 8385367]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016773 - phosphotransferase activity, alcohol group as acceptor [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 7989323]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 21121900]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IEA]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA] [PMID 7989323]; GO_process: GO:0046854 - phosphatidylinositol phosphorylation [Evidence IDA,IMP] [PMID 8385367]; GO_process: GO:0036092 - phosphatidylinositol-3-phosphate biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0048015 - phosphatidylinositol-mediated signaling [Evidence IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0032968 - positive regulation of transcription elongation from RNA polymerase II promoter [Evidence IMP] [PMID 23335340]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 7989323]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase
similar to AA sequence:KEGG_Orthology:K00121
Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IEA,IEA]; GO_function: GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IMP] [PMID 12499363]; GO_function: GO:0004022 - alcohol dehydrogenase (NAD) activity [Evidence IDA] [PMID 8483449]; GO_function: GO:0033833 - hydroxymethylfurfural reductase (NADH) activity [Evidence IMP] [PMID 16652391]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0000947 - amino acid catabolic process to alcohol via Ehrlich pathway [Evidence IGI] [PMID 12499363]; GO_process: GO:0006069 - ethanol oxidation [Evidence IEA]; GO_process: GO:0046294 - formaldehyde catabolic process [Evidence IDA] [PMID 8483449]; GO_process: GO:0033859 - furaldehyde metabolic process [Evidence IMP] [PMID 16652391]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00859
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA,IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14690591]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005635 - nuclear envelope [Evidence IDA] [PMID 14690591]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence IEA,IEA]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence ISS] [PMID 10592175]; GO_function: GO:0004140 - dephospho-CoA kinase activity [Evidence ISS] [PMID 14690591]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence ISS] [PMID 10592175]; GO_process: GO:0015937 - coenzyme A biosynthetic process [Evidence IGI] [PMID 19266201]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00077
2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0008677 - 2-dehydropantoate 2-reductase activity [Evidence IEA,IEA]; GO_function: GO:0008677 - 2-dehydropantoate 2-reductase activity [Evidence ISS] [PMID 11154694]; GO_function: GO:0050661 - NADP binding [Evidence IEA]; GO_function: GO:0050662 - coenzyme binding [Evidence IEA]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0015940 - pantothenate biosynthetic process [Evidence ISS] [PMID 11154694]
Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; GO_component: GO:0005575 - cellular_component [Evidence ND]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA]; GO_function: GO:0016279 - protein-lysine N-methyltransferase activity [Evidence IDA] [PMID 17005568]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0018026 - peptidyl-lysine monomethylation [Evidence IDA] [PMID 17005568]; GO_process: GO:0018023 - peptidyl-lysine trimethylation [Evidence IMP] [PMID 17005568]
similar to AA sequence:KEGG_Orthology:K10625
E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to ubiquitinate substrates in the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS); GO_component: GO:0005737 - cytoplasm [Evidence IGI,IMP] [PMID 20080635]; GO_component: GO:0008540 - proteasome regulatory particle, base subcomplex [Evidence IPI] [PMID 10688918]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IMP] [PMID 10581257]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0030433 - ER-associated ubiquitin-dependent protein catabolic process [Evidence IGI,IMP] [PMID 23988329]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 20080635]; GO_process: GO:0071629 - cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 22670231]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 10581257]; GO_process: GO:0000209 - protein polyubiquitination [Evidence IMP] [PMID 2209542]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0090089 - regulation of dipeptide transport [Evidence IMP] [PMID 9427760]; GO_process: GO:1990116 - ribosome-associated ubiquitin-dependent protein catabolic process [Evidence IMP] [PMID 23358411]; GO_process: GO:0071596 - ubiquitin-dependent protein catabolic process via the N-end rule pathway [Evidence IMP] [PMID 2209542]
similar to AA sequence:KEGG_Orthology:K01866
Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11359929]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA,IMP,ISS] [PMID 11359929]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004812 - aminoacyl-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IEA,IEA]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IDA] [PMID 782885]; GO_function: GO:0004831 - tyrosine-tRNA ligase activity [Evidence IDA,ISS] [PMID 8509419]; GO_process: GO:0006418 - tRNA aminoacylation for protein translation [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IEA]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IDA] [PMID 782885]; GO_process: GO:0006437 - tyrosyl-tRNA aminoacylation [Evidence IDA] [PMID 8509419]
similar to AA sequence:KEGG_Orthology:K12877
similar to AA sequence:KEGG_Orthology:K14439
similar to AA sequence:KEGG_Orthology:K15462
Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; GO_component: GO:0005737 - cytoplasm [Evidence IPI] [PMID 13680156]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 18466297]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0000226 - microtubule cytoskeleton organization [Evidence IGI,IMP] [PMID 13680156]; GO_process: GO:0007017 - microtubule-based process [Evidence IGI,ISS] [PMID 8070652]; GO_process: GO:0002098 - tRNA wobble uridine modification [Evidence IMP] [PMID 18755837]
similar to AA sequence:KEGG_Orthology:K02214
succinate-semialdehyde dehydrogenase (NAD(P)(+))
similar to AA sequence:KEGG_Orthology:K00135
Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IEA,IEA]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP,ISS] [PMID 11031268]; GO_function: GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity [Evidence IMP] [PMID 3888627]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEA,IEA]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IEP,IMP,ISS] [PMID 11031268]; GO_process: GO:0009450 - gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 3888627]; GO_process: GO:0006540 - glutamate decarboxylation to succinate [Evidence IGI,IMP,ISS] [PMID 11031268]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence ISS] [PMID 9678606]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0015663 - nicotinamide mononucleotide transmembrane transporter activity [Evidence IMP] [PMID 10869563]; GO_process: GO:0015890 - nicotinamide mononucleotide transport [Evidence IEP,IMP] [PMID 10869563]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17100
Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence ISS] [PMID 2843500]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IEA,IEA]; GO_function: GO:0004802 - transketolase activity [Evidence IMP,ISS] [PMID 8226984]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence IMP] [PMID 8299150]; GO_process: GO:0006098 - pentose-phosphate shunt [Evidence TAS] [PMID 8534086]
Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0017119 - Golgi transport complex [Evidence IPI] [PMID 11703943]; GO_component: GO:0005801 - cis-Golgi network [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0008565 - protein transporter activity [Evidence TAS] [PMID 12077121]; GO_process: GO:0032258 - CVT pathway [Evidence IMP] [PMID 20065092]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI] [PMID 10512869]; GO_process: GO:0006891 - intra-Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 11703943]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0016236 - macroautophagy [Evidence IMP] [PMID 20065092]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20065092]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0000301 - retrograde transport, vesicle recycling within Golgi [Evidence IMP] [PMID 11703943]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K00211
Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA]; GO_function: GO:0004665 - prephenate dehydrogenase (NADP+) activity [Evidence IEA,IEA]; GO_function: GO:0008977 - prephenate dehydrogenase activity [Evidence IEA]; GO_function: GO:0008977 - prephenate dehydrogenase activity [Evidence ISS] [PMID 2697638]; GO_process: GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]; GO_process: GO:0006571 - tyrosine biosynthetic process [Evidence IEA,IEA,IEA]; GO_process: GO:0006570 - tyrosine metabolic process [Evidence NAS] [PMID 11752249]
similar to AA sequence:KEGG_Orthology:K14850
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000781 - chromosome, telomeric region [Evidence IEA,IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10864042]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 23180764]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_function: GO:0008168 - methyltransferase activity [Evidence IEA,IEA]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence ISS] [PMID 10864042]; GO_function: GO:0016433 - rRNA (adenine) methyltransferase activity [Evidence IMP] [PMID 23180764]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0032259 - methylation [Evidence IEA]; GO_process: GO:0031167 - rRNA methylation [Evidence IMP] [PMID 23180764]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IGI,IMP] [PMID 10864042]; GO_process: GO:0042273 - ribosomal large subunit biogenesis [Evidence IGI] [PMID 23180764]
similar to AA sequence:KEGG_Orthology:K14561
Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0034457 - Mpp10 complex [Evidence IDA] [PMID 17515605]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12068309]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 12242301]; GO_function: GO:0042134 - rRNA primary transcript binding [Evidence IPI] [PMID 11864606]; GO_function: GO:0043047 - single-stranded telomeric DNA binding [Evidence IDA] [PMID 17803460]; GO_function: GO:0030515 - snoRNA binding [Evidence IDA] [PMID 15489263]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence TAS] [PMID 10690410]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14326
ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14763985]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence TAS] [PMID 10098411]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004004 - ATP-dependent RNA helicase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0008186 - RNA-dependent ATPase activity [Evidence TAS] [PMID 10322435]; GO_function: GO:0004386 - helicase activity [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence TAS] [PMID 10098411]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0043024 - ribosomal small subunit binding [Evidence IDA] [PMID 23801788]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006310 - DNA recombination [Evidence IMP] [PMID 23390378]; GO_process: GO:0030466 - chromatin silencing at silent mating-type cassette [Evidence IGI] [PMID 16157874]; GO_process: GO:0008298 - intracellular mRNA localization [Evidence IMP] [PMID 16777600]; GO_process: GO:0000956 - nuclear-transcribed mRNA catabolic process [Evidence IMP] [PMID 16285926]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI] [PMID 12769863]; GO_process: GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [Evidence IGI,IMP] [PMID 12881429]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence IEA,IEA]; GO_process: GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [Evidence TAS] [PMID 10098411]; GO_process: GO:0016567 - protein ubiquitination [Evidence IDA,IMP,IPI] [PMID 18676617]; GO_process: GO:0006449 - regulation of translational termination [Evidence TAS] [PMID 10098411]; GO_process: GO:0006452 - translational frameshifting [Evidence IMP] [PMID 15388879]
GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 10444589]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IBA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0031235 - intrinsic component of the cytoplasmic side of the plasma membrane [Evidence IBA]; GO_component: GO:0005628 - prospore membrane [Evidence IDA] [PMID 24390141]; GO_function: GO:0005096 - GTPase activator activity [Evidence IEA,IEA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IBA]; GO_function: GO:0005099 - Ras GTPase activator activity [Evidence IDA] [PMID 8371782]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007120 - axial cellular bud site selection [Evidence IMP] [PMID 22558355]; GO_process: GO:0007121 - bipolar cellular bud site selection [Evidence IMP] [PMID 2065354]; GO_process: GO:0007163 - establishment or maintenance of cell polarity [Evidence IMP] [PMID 23783029]; GO_process: GO:0030447 - filamentous growth [Evidence IMP] [PMID 15645503]; GO_process: GO:0036267 - invasive filamentous growth [Evidence IMP] [PMID 23783029]; GO_process: GO:0031578 - mitotic spindle orientation checkpoint [Evidence IMP] [PMID 22558355]; GO_process: GO:0046580 - negative regulation of Ras protein signal transduction [Evidence IBA]; GO_process: GO:0043547 - positive regulation of GTPase activity [Evidence IEA,IEA]; GO_process: GO:0032320 - positive regulation of Ras GTPase activity [Evidence IBA]; GO_process: GO:0051056 - regulation of small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K03164
Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; GO_component: GO:0097047 - DNA replication termination region [Evidence IPI] [PMID 20797631]; GO_component: GO:0009330 - DNA topoisomerase complex (ATP-hydrolyzing) [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 6088500]; GO_component: GO:0000795 - synaptonemal complex [Evidence IDA] [PMID 1315786]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003916 - DNA topoisomerase activity [Evidence IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6088500]; GO_function: GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity [Evidence IDA] [PMID 6323017]; GO_function: GO:0008094 - DNA-dependent ATPase activity [Evidence IBA]; GO_function: GO:0016853 - isomerase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0006259 - DNA metabolic process [Evidence IEA]; GO_process: GO:0006271 - DNA strand elongation involved in DNA replication [Evidence IMP] [PMID 2549254]; GO_process: GO:0006265 - DNA topological change [Evidence IEA]; GO_process: GO:0006265 - DNA topological change [Evidence IDA] [PMID 6088500]; GO_process: GO:0006268 - DNA unwinding involved in DNA replication [Evidence IMP] [PMID 24062159]; GO_process: GO:0006333 - chromatin assembly or disassembly [Evidence IMP] [PMID 9199287]; GO_process: GO:0031055 - chromatin remodeling at centromere [Evidence IMP] [PMID 18701701]; GO_process: GO:0044774 - mitotic DNA integrity checkpoint [Evidence IMP] [PMID 16651657]; GO_process: GO:0007131 - reciprocal meiotic recombination [Evidence IMP] [PMID 2156624]; GO_process: GO:0000019 - regulation of mitotic recombination [Evidence IMP] [PMID 2902925]; GO_process: GO:0097046 - replication fork progression beyond termination site [Evidence IMP] [PMID 20797631]; GO_process: GO:0000712 - resolution of meiotic recombination intermediates [Evidence IBA]; GO_process: GO:0000819 - sister chromatid segregation [Evidence IBA]
retrotransposon-derived protein PEG10 isoform 1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18667581]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19111667]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IDA] [PMID 19158363]; GO_process: GO:0000436 - carbon catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 18667581]; GO_process: GO:0061416 - regulation of transcription from RNA polymerase II promoter in response to salt stress [Evidence IMP] [PMID 18667581]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K17267
Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo; GO_component: GO:0030126 - COPI vesicle coat [Evidence IEA]; GO_component: GO:0030126 - COPI vesicle coat [Evidence IDA] [PMID 1461285]; GO_component: GO:0030663 - COPI-coated vesicle membrane [Evidence IEA]; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0031410 - cytoplasmic vesicle [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IEA,IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 17101773]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0030117 - membrane coat [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0005198 - structural molecule activity [Evidence IEA]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IMP] [PMID 1461285]; GO_process: GO:0006886 - intracellular protein transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006890 - retrograde vesicle-mediated transport, Golgi to ER [Evidence IMP] [PMID 8001155]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0016192 - vesicle-mediated transport [Evidence IEA,IEA]
Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0046658 - anchored component of plasma membrane [Evidence IDA,IPI] [PMID 11016834]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0004190 - aspartic-type endopeptidase activity [Evidence IDA,ISS] [PMID 10191273]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IGI] [PMID 16087741]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K00863
Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IEA,IEA]; GO_function: GO:0004371 - glycerone kinase activity [Evidence IDA] [PMID 12401799]; GO_function: GO:0004371 - glycerone kinase activity [Evidence ISS] [PMID 9038161]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0050354 - triokinase activity [Evidence IEA]; GO_process: GO:0019588 - anaerobic glycerol catabolic process [Evidence IEA]; GO_process: GO:0097237 - cellular response to toxic substance [Evidence IMP] [PMID 12401799]; GO_process: GO:0019563 - glycerol catabolic process [Evidence ISS] [PMID 9038161]; GO_process: GO:0006071 - glycerol metabolic process [Evidence IEA,IEA]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
mitochondrial 54S ribosomal protein YmL36
Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]
similar to AA sequence:KEGG_Orthology:K12859
17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005682 - U5 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 10610776]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IMP] [PMID 11720284]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K14454
Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 9288922]; GO_component: GO:0005777 - peroxisome [Evidence IEA,IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA,IMP] [PMID 9288922]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IDA] [PMID 1859361]; GO_function: GO:0004069 - L-aspartate:2-oxoglutarate aminotransferase activity [Evidence IMP] [PMID 9288922]; GO_function: GO:0080130 - L-phenylalanine:2-oxoglutarate aminotransferase activity [Evidence IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0030170 - pyridoxal phosphate binding [Evidence IEA]; GO_function: GO:0008483 - transaminase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 15780654]; GO_process: GO:0006532 - aspartate biosynthetic process [Evidence IMP] [PMID 9288922]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0006520 - cellular amino acid metabolic process [Evidence IEA]
mitogen-activated serine/threonine-protein kinase FUS3
similar to AA sequence:KEGG_Orthology:K04371
Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 10233162]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 11781566]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 17952059]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10233162]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 18417610]; GO_component: GO:0042597 - periplasmic space [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IEA,IEA]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 15620357]; GO_function: GO:0004707 - MAP kinase activity [Evidence IDA] [PMID 8384702]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IEA]; GO_function: GO:0004672 - protein kinase activity [Evidence IDA] [PMID 16319894]; GO_function: GO:0004674 - protein serine/threonine kinase activity [Evidence IEA,IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016772 - transferase activity, transferring phosphorus-containing groups [Evidence IEA]; GO_process: GO:0000165 - MAPK cascade [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0007050 - cell cycle arrest [Evidence IMP] [PMID 10049917]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0000746 - conjugation [Evidence IEA]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 10652102]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 15620357]; GO_process: GO:0001403 - invasive growth in response to glucose limitation [Evidence IMP] [PMID 8001818]; GO_process: GO:0007067 - mitotic nuclear division [Evidence IEA]; GO_process: GO:0043409 - negative regulation of MAPK cascade [Evidence IPI] [PMID 16424299]; GO_process: GO:0010526 - negative regulation of transposition, RNA-mediated [Evidence IMP] [PMID 9566871]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IDA] [PMID 15620357]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IDA] [PMID 8384702]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]; GO_process: GO:0046827 - positive regulation of protein export from nucleus [Evidence IMP] [PMID 22588722]; GO_process: GO:0006468 - protein phosphorylation [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 16319894]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 22588722]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 8384702]
similar to AA sequence:KEGG_Orthology:K02896
Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022625 - cytosolic large ribosomal subunit [Evidence IDA] [PMID 11983894]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IDA] [PMID 6337137]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IC] [PMID 11983894]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 11983894]
similar to AA sequence:KEGG_Orthology:K16803
Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p; GO_component: GO:0005938 - cell cortex [Evidence IDA] [PMID 11511347]; GO_component: GO:0000778 - condensed nuclear chromosome kinetochore [Evidence IDA] [PMID 11511347]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0000776 - kinetochore [Evidence IDA] [PMID 11553724]; GO_component: GO:0005874 - microtubule [Evidence IEA]; GO_component: GO:0005819 - spindle [Evidence IEA]; GO_component: GO:0005876 - spindle microtubule [Evidence IDA] [PMID 11511347]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 9606209]; GO_function: GO:0008017 - microtubule binding [Evidence IMP] [PMID 11553724]; GO_function: GO:0005200 - structural constituent of cytoskeleton [Evidence IPI] [PMID 9606209]; GO_process: GO:0007020 - microtubule nucleation [Evidence IPI] [PMID 9153752]; GO_process: GO:0030472 - mitotic spindle organization in nucleus [Evidence IGI] [PMID 11756468]
similar to AA sequence:KEGG_Orthology:K03521
Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0009055 - electron carrier activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K15918
ATP-binding hypothetical protein; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 14997573]; GO_function: GO:0016301 - kinase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0016310 - phosphorylation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14997
Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11274162]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence ISS] [PMID 11274162]
formin (bud-site selection/polarity protein), putative
similar to AA sequence:KEGG_Orthology:K10997
Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0000228 - nuclear chromosome [Evidence IPI] [PMID 12944972]; GO_component: GO:0043596 - nuclear replication fork [Evidence IDA] [PMID 16103218]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0031298 - replication fork protection complex [Evidence IDA] [PMID 16531994]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0006281 - DNA repair [Evidence IGI,IMP] [PMID 16219777]; GO_process: GO:0006260 - DNA replication [Evidence IMP] [PMID 16137625]; GO_process: GO:0000076 - DNA replication checkpoint [Evidence IMP,IPI] [PMID 12944972]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0043570 - maintenance of DNA repeat elements [Evidence IMP] [PMID 18321795]; GO_process: GO:0007126 - meiotic nuclear division [Evidence IEA]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 14742714]; GO_process: GO:0007064 - mitotic sister chromatid cohesion [Evidence IGI,IMP] [PMID 17483413]; GO_process: GO:0008156 - negative regulation of DNA replication [Evidence IEA]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16103218]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 16418273]; GO_process: GO:0043111 - replication fork arrest [Evidence IMP] [PMID 17652453]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 16418273]; GO_process: GO:0048478 - replication fork protection [Evidence IMP] [PMID 18632578]
methylthioribulose 1-phosphate dehydratase MDE1
similar to AA sequence:KEGG_Orthology:K08964
5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016829 - lyase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IEA,IEA]; GO_function: GO:0046570 - methylthioribulose 1-phosphate dehydratase activity [Evidence IMP] [PMID 18625006]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0019284 - L-methionine biosynthetic process from S-adenosylmethionine [Evidence IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IEA,IEA]; GO_process: GO:0019509 - L-methionine salvage from methylthioadenosine [Evidence IMP] [PMID 18625006]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0009086 - methionine biosynthetic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K10696
E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing; GO_component: GO:0000790 - nuclear chromatin [Evidence IDA] [PMID 12876294]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003688 - DNA replication origin binding [Evidence IDA] [PMID 23103252]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA,IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 19531475]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0016568 - chromatin modification [Evidence IEA]; GO_process: GO:0006348 - chromatin silencing at telomere [Evidence IMP] [PMID 12535539]; GO_process: GO:0000724 - double-strand break repair via homologous recombination [Evidence IGI] [PMID 16783014]; GO_process: GO:0010390 - histone monoubiquitination [Evidence IMP] [PMID 12535538]; GO_process: GO:0010390 - histone monoubiquitination [Evidence IMP] [PMID 12535539]; GO_process: GO:0016574 - histone ubiquitination [Evidence IMP] [PMID 23103252]; GO_process: GO:0031573 - intra-S DNA damage checkpoint [Evidence IMP] [PMID 15632126]; GO_process: GO:0042138 - meiotic DNA double-strand break formation [Evidence IMP] [PMID 15280549]; GO_process: GO:0031571 - mitotic G1 DNA damage checkpoint [Evidence IMP] [PMID 16166626]; GO_process: GO:0031571 - mitotic G1 DNA damage checkpoint [Evidence IMP] [PMID 16783014]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]; GO_process: GO:0030174 - regulation of DNA-dependent DNA replication initiation [Evidence IMP] [PMID 23103252]; GO_process: GO:0000722 - telomere maintenance via recombination [Evidence IGI] [PMID 23390378]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IGI] [PMID 15632065]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IPI] [PMID 19531475]
similar to AA sequence:KEGG_Orthology:K11244
Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 17761172]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 9391108]; GO_function: GO:0004888 - transmembrane signaling receptor activity [Evidence IGI,ISS] [PMID 10430578]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IMP] [PMID 10348843]; GO_process: GO:0007266 - Rho protein signal transduction [Evidence IMP] [PMID 10508863]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 10508863]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 10508863]; GO_process: GO:0030010 - establishment of cell polarity [Evidence IMP] [PMID 24326069]; GO_process: GO:0031505 - fungal-type cell wall organization [Evidence IMP] [PMID 10348843]; GO_process: GO:0030242 - peroxisome degradation [Evidence IMP] [PMID 20385774]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 24326069]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 10348843]; GO_process: GO:0009408 - response to heat [Evidence IMP] [PMID 10508863]; GO_process: GO:0006970 - response to osmotic stress [Evidence IGI] [PMID 14871941]; GO_process: GO:0006950 - response to stress [Evidence IEA]
CDP-diacylglycerol-serine O-phosphatidyltransferase
similar to AA sequence:KEGG_Orthology:K17103
Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 2002005]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IDA] [PMID 6274497]; GO_component: GO:0043231 - intracellular membrane-bounded organelle [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 3005242]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0031090 - organelle membrane [Evidence IEA]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IEA]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IDA] [PMID 6088519]; GO_function: GO:0003882 - CDP-diacylglycerol-serine O-phosphatidyltransferase activity [Evidence IMP] [PMID 6988386]; GO_function: GO:0016780 - phosphotransferase activity, for other substituted phosphate groups [Evidence IEA]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0006646 - phosphatidylethanolamine biosynthetic process [Evidence IEA]; GO_process: GO:0006659 - phosphatidylserine biosynthetic process [Evidence IDA] [PMID 6088519]; GO_process: GO:0006659 - phosphatidylserine biosynthetic process [Evidence IMP] [PMID 6988386]; GO_process: GO:0008654 - phospholipid biosynthetic process [Evidence IEA,IEA]
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication; GO_component: GO:0031932 - TORC2 complex [Evidence IPI] [PMID 15689497]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0032126 - eisosome [Evidence IDA] [PMID 21451250]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0045121 - membrane raft [Evidence IDA] [PMID 19064668]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15372071]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 15689497]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 17101780]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 15689497]; GO_function: GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding [Evidence IDA] [PMID 21119626]; GO_function: GO:0046625 - sphingolipid binding [Evidence IDA] [PMID 21119626]; GO_process: GO:0031929 - TOR signaling [Evidence IPI] [PMID 15689497]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15372071]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IGI] [PMID 15689497]; GO_process: GO:0051017 - actin filament bundle assembly [Evidence IGI] [PMID 15689497]; GO_process: GO:0070941 - eisosome assembly [Evidence IGI] [PMID 21451250]; GO_process: GO:0016197 - endosomal transport [Evidence IGI] [PMID 21451250]; GO_process: GO:0030950 - establishment or maintenance of actin cytoskeleton polarity [Evidence IPI] [PMID 15689497]; GO_process: GO:0001558 - regulation of cell growth [Evidence IGI,IPI] [PMID 15689497]
similar to AA sequence:KEGG_Orthology:K03844
Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IDA] [PMID 11278778]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0004377 - GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [Evidence IEA]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IGI] [PMID 11278778]; GO_function: GO:0000026 - alpha-1,2-mannosyltransferase activity [Evidence IDA] [PMID 16878994]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_function: GO:0016757 - transferase activity, transferring glycosyl groups [Evidence IEA]; GO_process: GO:0009058 - biosynthetic process [Evidence IEA]; GO_process: GO:0097502 - mannosylation [Evidence IEA]; GO_process: GO:0006490 - oligosaccharide-lipid intermediate biosynthetic process [Evidence IDA] [PMID 16878994]; GO_process: GO:0006486 - protein glycosylation [Evidence IEA]; GO_process: GO:0006486 - protein glycosylation [Evidence IGI] [PMID 11278778]
similar to AA sequence:KEGG_Orthology:K06685
Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; GO_component: GO:0005935 - cellular bud neck [Evidence IEA]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 11434459]; GO_component: GO:0005694 - chromosome [Evidence IEA]; GO_component: GO:0000775 - chromosome, centromeric region [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_component: GO:0034399 - nuclear periphery [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IEA]; GO_component: GO:0005816 - spindle pole body [Evidence IDA] [PMID 11434459]; GO_function: GO:0019207 - kinase regulator activity [Evidence IDA] [PMID 11404483]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0051301 - cell division [Evidence IEA]; GO_process: GO:0006468 - protein phosphorylation [Evidence IDA] [PMID 11404483]; GO_process: GO:0007096 - regulation of exit from mitosis [Evidence TAS] [PMID 11404483]
hypothetical protein; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14562095]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]
similar to AA sequence:KEGG_Orthology:K01338
ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; GO_component: GO:0005759 - mitochondrial matrix [Evidence IEA,IEA]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8146662]; GO_component: GO:0005759 - mitochondrial matrix [Evidence IMP] [PMID 8276800]; GO_component: GO:0042645 - mitochondrial nucleoid [Evidence IBA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IEA,IEA]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8146662]; GO_function: GO:0004176 - ATP-dependent peptidase activity [Evidence IMP] [PMID 8276800]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0070361 - mitochondrial light strand promoter anti-sense binding [Evidence IBA]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0043565 - sequence-specific DNA binding [Evidence IEA]; GO_function: GO:0004252 - serine-type endopeptidase activity [Evidence IEA,IEA]; GO_function: GO:0008236 - serine-type peptidase activity [Evidence IEA]; GO_function: GO:0003697 - single-stranded DNA binding [Evidence IBA]; GO_function: GO:0003727 - single-stranded RNA binding [Evidence IBA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA,IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IBA,IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IEA]; GO_process: GO:0051131 - chaperone-mediated protein complex assembly [Evidence IGI] [PMID 8810243]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IEA,IEA]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IMP] [PMID 16336126]; GO_process: GO:0006515 - misfolded or incompletely synthesized protein catabolic process [Evidence IGI,IMP] [PMID 7957078]; GO_process: GO:0007005 - mitochondrion organization [Evidence IBA]; GO_process: GO:0070407 - oxidation-dependent protein catabolic process [Evidence IBA,IEA]; GO_process: GO:0030163 - protein catabolic process [Evidence IEA]; GO_process: GO:0051260 - protein homooligomerization [Evidence IBA]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0090296 - regulation of mitochondrial DNA replication [Evidence IEA]; GO_process: GO:0001666 - response to hypoxia [Evidence IBA]
similar to AA sequence:KEGG_Orthology:K07973
G protein gamma subunit; forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 8995254]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IEA]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IMP] [PMID 2105453]; GO_component: GO:0005834 - heterotrimeric G-protein complex [Evidence IDA] [PMID 8995254]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 8995254]; GO_function: GO:0004871 - signal transducer activity [Evidence IEA,IEA]; GO_function: GO:0004871 - signal transducer activity [Evidence IMP] [PMID 2107073]; GO_process: GO:0007186 - G-protein coupled receptor signaling pathway [Evidence IEA]; GO_process: GO:0031684 - heterotrimeric G-protein complex cycle [Evidence IMP] [PMID 2107073]; GO_process: GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion [Evidence IMP] [PMID 3151178]; GO_process: GO:0019236 - response to pheromone [Evidence IEA]; GO_process: GO:0007165 - signal transduction [Evidence IEA]
asparagine synthase (glutamine-hydrolyzing) 2
similar to AA sequence:KEGG_Orthology:K01953
Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IEA,IEA]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence IDA] [PMID 6105958]; GO_function: GO:0004066 - asparagine synthase (glutamine-hydrolyzing) activity [Evidence ISS] [PMID 8951815]; GO_function: GO:0016874 - ligase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0070981 - L-asparagine biosynthetic process [Evidence IEA]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IEA,IEA]; GO_process: GO:0006529 - asparagine biosynthetic process [Evidence IGI] [PMID 8951815]; GO_process: GO:0008652 - cellular amino acid biosynthetic process [Evidence IEA]; GO_process: GO:0006541 - glutamine metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04079
Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0042623 - ATPase activity, coupled [Evidence IDA] [PMID 12235160]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IDA] [PMID 10564510]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IDA] [PMID 10564510]; GO_process: GO:0006458 - 'de novo' protein folding [Evidence IMP] [PMID 9371781]; GO_process: GO:0000492 - box C/D snoRNP assembly [Evidence IMP] [PMID 18268103]; GO_process: GO:0032212 - positive regulation of telomere maintenance via telomerase [Evidence IDA,IMP,IPI] [PMID 17954556]; GO_process: GO:0043248 - proteasome assembly [Evidence IDA,IGI,IMP] [PMID 12853471]; GO_process: GO:0006457 - protein folding [Evidence IEA]; GO_process: GO:0042026 - protein refolding [Evidence IMP] [PMID 9371781]; GO_process: GO:0006626 - protein targeting to mitochondrion [Evidence IPI] [PMID 12526792]; GO_process: GO:0006970 - response to osmotic stress [Evidence IMP] [PMID 16487343]; GO_process: GO:0006950 - response to stress [Evidence IEA,IEA]
Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene; GO_component: GO:0005622 - intracellular [Evidence IDA] [PMID 23438601]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0044376 - RNA polymerase II complex localization to nucleus [Evidence IMP,IPI] [PMID 23438601]
similar to AA sequence:KEGG_Orthology:K07893
Rab family GTPase; Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; resides temporarily at the Golgi, dissociates into cytosol upon arrival of the Rab GTPaseYpt32p, which also functions in the late Golgi; Golgi-localized form is bound to GTP, while cytosolic form is GDP-bound; homolog of the mammalian Rab6; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 24194547]; GO_component: GO:0005801 - cis-Golgi network [Evidence IDA] [PMID 24924636]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 24924636]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11210571]; GO_function: GO:0003924 - GTPase activity [Evidence ISS] [PMID 9433126]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0006886 - intracellular protein transport [Evidence IGI] [PMID 10990452]; GO_process: GO:0015031 - protein transport [Evidence IEA,IEA]; GO_process: GO:0042147 - retrograde transport, endosome to Golgi [Evidence IMP] [PMID 11160819]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K16055
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress; GO_component: GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [Evidence IGI,IMP,IPI] [PMID 9837904]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IEA]; GO_function: GO:0004805 - trehalose-phosphatase activity [Evidence IMP] [PMID 8444170]; GO_process: GO:0034605 - cellular response to heat [Evidence IMP] [PMID 8203161]; GO_process: GO:0034605 - cellular response to heat [Evidence IDA] [PMID 8444170]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0006950 - response to stress [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IEA]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IMP] [PMID 8203161]; GO_process: GO:0005992 - trehalose biosynthetic process [Evidence IMP] [PMID 8444170]
Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IC] [PMID 20581295]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0001128 - RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IPI] [PMID 10906145]; GO_function: GO:0001190 - RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [Evidence IMP] [PMID 17603098]; GO_function: GO:0001135 - RNA polymerase II transcription factor recruiting transcription factor activity [Evidence IDA,IMP] [PMID 21515579]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0000981 - sequence-specific DNA binding RNA polymerase II transcription factor activity [Evidence IEA]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IPI] [PMID 10906145]; GO_process: GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter [Evidence IMP] [PMID 7899074]; GO_process: GO:1901717 - positive regulation of gamma-aminobutyric acid catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:1901714 - positive regulation of urea catabolic process [Evidence IMP] [PMID 2406136]; GO_process: GO:0006355 - regulation of transcription, DNA-templated [Evidence IEA,IEA]; GO_process: GO:0006366 - transcription from RNA polymerase II promoter [Evidence IEA]; GO_process: GO:0006351 - transcription, DNA-templated [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K10755
Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0031390 - Ctf18 RFC-like complex [Evidence IPI] [PMID 11389843]; GO_component: GO:0005663 - DNA replication factor C complex [Evidence IDA,ISS] [PMID 8063832]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12909721]; GO_component: GO:0031391 - Elg1 RFC-like complex [Evidence IPI] [PMID 12912927]; GO_component: GO:0031389 - Rad17 RFC-like complex [Evidence IDA] [PMID 12604797]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0003677 - DNA binding [Evidence IEA,IEA]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 12604797]; GO_function: GO:0003689 - DNA clamp loader activity [Evidence IDA] [PMID 8995429]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006260 - DNA replication [Evidence IEA,IEA]; GO_process: GO:0007049 - cell cycle [Evidence IEA]; GO_process: GO:0006272 - leading strand elongation [Evidence IDA] [PMID 1346062]; GO_process: GO:0006298 - mismatch repair [Evidence TAS] [PMID 10072354]; GO_process: GO:0007062 - sister chromatid cohesion [Evidence IPI] [PMID 11389843]
similar to AA sequence:KEGG_Orthology:K04709
Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication; GO_component: GO:0061576 - acyl-CoA ceramide synthase complex [Evidence IDA] [PMID 15692566]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 11914276]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IEA]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11387200]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IMP] [PMID 11694577]; GO_function: GO:0050291 - sphingosine N-acyltransferase activity [Evidence IDA] [PMID 15692566]; GO_function: GO:0016740 - transferase activity [Evidence IEA]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IMP] [PMID 11694577]; GO_process: GO:0046513 - ceramide biosynthetic process [Evidence IDA] [PMID 15692566]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0001302 - replicative cell aging [Evidence IEP,IMP] [PMID 8195187]
similar to AA sequence:KEGG_Orthology:K11246
Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication; GO_component: GO:0000324 - fungal-type vacuole [Evidence IDA] [PMID 11274162]; GO_component: GO:0000329 - fungal-type vacuole membrane [Evidence IDA] [PMID 20118605]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005774 - vacuolar membrane [Evidence IEA]; GO_component: GO:0005773 - vacuole [Evidence IEA]; GO_function: GO:0015183 - L-aspartate transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005313 - L-glutamate transmembrane transporter activity [Evidence IMP] [PMID 11274162]; GO_function: GO:0005215 - transporter activity [Evidence ISS] [PMID 11274162]; GO_process: GO:0032974 - amino acid transmembrane export from vacuole [Evidence IMP] [PMID 11274162]; GO_process: GO:0006865 - amino acid transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IMP] [PMID 11274162]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K14840
Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005730 - nucleolus [Evidence IDA] [PMID 16043506]; GO_component: GO:0005654 - nucleoplasm [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 10684247]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 16043506]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0019843 - rRNA binding [Evidence IDA] [PMID 16128814]; GO_process: GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 15686447]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0006364 - rRNA processing [Evidence IMP] [PMID 16128814]; GO_process: GO:0000055 - ribosomal large subunit export from nucleus [Evidence IMP] [PMID 16043506]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]
Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs; GO_component: GO:0005688 - U6 snRNP [Evidence IDA] [PMID 11720284]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0017070 - U6 snRNA binding [Evidence IDA] [PMID 20181740]; GO_function: GO:0003676 - nucleic acid binding [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_function: GO:0017069 - snRNA binding [Evidence IPI] [PMID 16410014]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000245 - spliceosomal complex assembly [Evidence IMP] [PMID 10022888]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IDA] [PMID 9452384]
similar to AA sequence:KEGG_Orthology:K11886
Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 20620957]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_component: GO:0000502 - proteasome complex [Evidence IEA]; GO_component: GO:0000502 - proteasome complex [Evidence IDA] [PMID 12408819]; GO_function: GO:0032947 - protein complex scaffold [Evidence IDA] [PMID 20620957]; GO_process: GO:0043248 - proteasome assembly [Evidence IDA] [PMID 20620957]
Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0005097 - Rab GTPase activator activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0032851 - positive regulation of Rab GTPase activity [Evidence IEA]; GO_process: GO:0032313 - regulation of Rab GTPase activity [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05533
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol; GO_component: GO:0005794 - Golgi apparatus [Evidence IEA]; GO_component: GO:0000137 - Golgi cis cisterna [Evidence IDA] [PMID 9430634]; GO_component: GO:0000139 - Golgi membrane [Evidence IEA]; GO_component: GO:0000136 - alpha-1,6-mannosyltransferase complex [Evidence IPI] [PMID 9430634]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0000009 - alpha-1,6-mannosyltransferase activity [Evidence IDA] [PMID 10037752]; GO_function: GO:0000030 - mannosyltransferase activity [Evidence ISS] [PMID 9434768]; GO_process: GO:0006487 - protein N-linked glycosylation [Evidence IDA,IMP] [PMID 9430634]
similar to AA sequence:KEGG_Orthology:K10599
Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia; GO_component: GO:0000974 - Prp19 complex [Evidence IDA] [PMID 8194532]; GO_component: GO:0071006 - U2-type catalytic step 1 spliceosome [Evidence IDA] [PMID 8248176]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0005829 - cytosol [Evidence IDA] [PMID 22932476]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 11914276]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22932476]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_component: GO:0000151 - ubiquitin ligase complex [Evidence IEA]; GO_function: GO:0000384 - first spliceosomal transesterification activity [Evidence IC] [PMID 8248176]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IEA]; GO_function: GO:0004842 - ubiquitin-protein transferase activity [Evidence IDA,IMP] [PMID 12627222]; GO_process: GO:0006281 - DNA repair [Evidence IEA]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006974 - cellular response to DNA damage stimulus [Evidence IEA]; GO_process: GO:0000349 - generation of catalytic spliceosome for first transesterification step [Evidence IMP] [PMID 12970570]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0016567 - protein ubiquitination [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K18703
mitochondrial 54S ribosomal protein YmL22
Mitochondrial ribosomal protein of the large subunit; GO_component: GO:0015934 - large ribosomal subunit [Evidence IEA]; GO_component: GO:0005762 - mitochondrial large ribosomal subunit [Evidence IPI] [PMID 12392552]; GO_component: GO:0005739 - mitochondrion [Evidence IEA,IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IPI] [PMID 12392552]; GO_process: GO:0032543 - mitochondrial translation [Evidence IC] [PMID 12392552]; GO_process: GO:0006412 - translation [Evidence IEA]
Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 21124907]; GO_function: GO:0016791 - phosphatase activity [Evidence IEA]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IEA]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IMP] [PMID 10900271]; GO_function: GO:0004438 - phosphatidylinositol-3-phosphatase activity [Evidence IMP] [PMID 15169871]; GO_function: GO:0004725 - protein tyrosine phosphatase activity [Evidence IEA]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0035335 - peptidyl-tyrosine dephosphorylation [Evidence IEA]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IMP] [PMID 10900271]; GO_process: GO:0046856 - phosphatidylinositol dephosphorylation [Evidence IGI,IMP] [PMID 15169871]
Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA,ISS] [PMID 1423607]; GO_component: GO:0030176 - integral component of endoplasmic reticulum membrane [Evidence IDA] [PMID 15623581]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 19053807]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP,IPI] [PMID 10564255]; GO_function: GO:0051082 - unfolded protein binding [Evidence IMP] [PMID 15623581]; GO_process: GO:0006888 - ER to Golgi vesicle-mediated transport [Evidence IGI,IPI] [PMID 10564255]; GO_process: GO:0006457 - protein folding [Evidence IMP] [PMID 15623581]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K02985
Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 18782943]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 3533916]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 385049]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030688 - preribosome, small subunit precursor [Evidence IDA] [PMID 16738661]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003906 - DNA-(apurinic or apyrimidinic site) lyase activity [Evidence IDA] [PMID 11561734]; GO_function: GO:0003723 - RNA binding [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 18782943]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 3533916]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IC] [PMID 385049]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IMP] [PMID 16246728]; GO_process: GO:0000056 - ribosomal small subunit export from nucleus [Evidence IGI] [PMID 22570489]; GO_process: GO:0006412 - translation [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K13091
Non-essential hypothetical protein; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 14562095]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 22842922]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 9200815]; GO_process: GO:0008150 - biological_process [Evidence ND]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]
Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway; GO_component: GO:0030479 - actin cortical patch [Evidence IEA]; GO_component: GO:0030479 - actin cortical patch [Evidence IDA] [PMID 11489916]; GO_component: GO:0015629 - actin cytoskeleton [Evidence IPI] [PMID 10992286]; GO_component: GO:0005737 - cytoplasm [Evidence IEA]; GO_component: GO:0005856 - cytoskeleton [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IEA]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA,IMP] [PMID 23071111]; GO_function: GO:0008195 - phosphatidate phosphatase activity [Evidence IDA] [PMID 23335564]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IPI] [PMID 10992286]; GO_process: GO:0044255 - cellular lipid metabolic process [Evidence IMP] [PMID 23071111]; GO_process: GO:0016311 - dephosphorylation [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K05863
Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 795470]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IPI] [PMID 16962558]; GO_function: GO:0005471 - ATP:ADP antiporter activity [Evidence IDA] [PMID 8476415]; GO_function: GO:0005215 - transporter activity [Evidence IEA]; GO_process: GO:0015866 - ADP transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0015867 - ATP transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0009060 - aerobic respiration [Evidence IMP] [PMID 2167309]; GO_process: GO:0009061 - anaerobic respiration [Evidence IGI] [PMID 1915842]; GO_process: GO:0006915 - apoptotic process [Evidence IMP] [PMID 17822411]; GO_process: GO:0015886 - heme transport [Evidence IMP,IPI] [PMID 18728780]; GO_process: GO:0006839 - mitochondrial transport [Evidence IMP] [PMID 2167309]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IDA] [PMID 8476415]; GO_process: GO:0006810 - transport [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K08956
Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 11914276]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0005745 - m-AAA complex [Evidence IDA] [PMID 8681382]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_component: GO:0097002 - mitochondrial inner boundary membrane [Evidence IDA] [PMID 19019989]; GO_component: GO:0005743 - mitochondrial inner membrane [Evidence IDA] [PMID 7929327]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 11914276]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence IDA] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence IDA,IMP] [PMID 19748354]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 7929327]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0004222 - metalloendopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IEA]; GO_function: GO:0008237 - metallopeptidase activity [Evidence IMP] [PMID 8681382]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_function: GO:0008233 - peptidase activity [Evidence IEA]; GO_function: GO:0005515 - protein binding [Evidence IPI] [PMID 19748354]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0006461 - protein complex assembly [Evidence IMP] [PMID 8681382]; GO_process: GO:0045041 - protein import into mitochondrial intermembrane space [Evidence TAS] [PMID 12417197]; GO_process: GO:0006508 - proteolysis [Evidence IEA,IEA]; GO_process: GO:0006508 - proteolysis [Evidence IMP] [PMID 8681382]; GO_process: GO:0006465 - signal peptide processing [Evidence IMP] [PMID 12417197]
similar to hypothetical protein; allele of CaO19.13270
similar to AA sequence:KEGG_Orthology:K10436
similar to AA sequence:KEGG_Orthology:K02998
Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IDA] [PMID 8626693]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0015935 - small ribosomal subunit [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA,IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IDA] [PMID 8626693]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 8626693]; GO_process: GO:0002181 - cytoplasmic translation [Evidence IMP] [PMID 9973221]; GO_process: GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Evidence IMP] [PMID 14627813]; GO_process: GO:0006407 - rRNA export from nucleus [Evidence IGI] [PMID 16246728]; GO_process: GO:0006364 - rRNA processing [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IEA]; GO_process: GO:0000028 - ribosomal small subunit assembly [Evidence IMP] [PMID 8626693]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0006412 - translation [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K02993
Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication; GO_component: GO:0030686 - 90S preribosome [Evidence IDA] [PMID 12150911]; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence IBA]; GO_component: GO:0022627 - cytosolic small ribosomal subunit [Evidence NAS] [PMID 9559554]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005730 - nucleolus [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005840 - ribosome [Evidence IEA,IEA]; GO_component: GO:0032040 - small-subunit processome [Evidence IDA] [PMID 15590835]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence IEA]; GO_function: GO:0003735 - structural constituent of ribosome [Evidence NAS] [PMID 9559554]; GO_process: GO:0002181 - cytoplasmic translation [Evidence NAS] [PMID 9559554]; GO_process: GO:0006364 - rRNA processing [Evidence IBA,IEA]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IBA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IEA]; GO_process: GO:0042254 - ribosome biogenesis [Evidence IGI] [PMID 16246728]; GO_process: GO:0006412 - translation [Evidence IEA]
Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0005887 - integral component of plasma membrane [Evidence IC] [PMID 9643541]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0015198 - oligopeptide transporter activity [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0006857 - oligopeptide transport [Evidence IDA,ISS] [PMID 9643541]; GO_process: GO:0015833 - peptide transport [Evidence IEA]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]; GO_process: GO:0042144 - vacuole fusion, non-autophagic [Evidence IMP] [PMID 19767828]
similar to AA sequence:KEGG_Orthology:K03235
ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; GO_component: GO:0005737 - cytoplasm [Evidence IEA,IEA]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 23222640]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005844 - polysome [Evidence IDA] [PMID 19806183]; GO_component: GO:0030687 - preribosome, large subunit precursor [Evidence IDA] [PMID 23212245]; GO_function: GO:0005524 - ATP binding [Evidence IEA,IEA]; GO_function: GO:0005524 - ATP binding [Evidence ISS] [PMID 12110682]; GO_function: GO:0016887 - ATPase activity [Evidence IEA]; GO_function: GO:0016887 - ATPase activity [Evidence ISS] [PMID 12110682]; GO_function: GO:0003729 - mRNA binding [Evidence IDA] [PMID 23222640]; GO_function: GO:0017111 - nucleoside-triphosphatase activity [Evidence IEA]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA,IEA]; GO_process: GO:0006200 - ATP catabolic process [Evidence IEA]; GO_process: GO:0051028 - mRNA transport [Evidence IEA]; GO_process: GO:0016973 - poly(A)+ mRNA export from nucleus [Evidence ISS] [PMID 12110682]; GO_process: GO:0042274 - ribosomal small subunit biogenesis [Evidence IMP] [PMID 19806183]; GO_process: GO:0006810 - transport [Evidence IEA]
Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication; GO_component: GO:0016021 - integral component of membrane [Evidence IEA,IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016021 - integral component of membrane [Evidence ISS] [PMID 9353309]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0031966 - mitochondrial membrane [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 9353309]; GO_function: GO:0008324 - cation transmembrane transporter activity [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0006812 - cation transport [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IEA]; GO_process: GO:0006879 - cellular iron ion homeostasis [Evidence IGI,IMP] [PMID 9353309]; GO_process: GO:0006811 - ion transport [Evidence IEA]; GO_process: GO:0055072 - iron ion homeostasis [Evidence IEA]; GO_process: GO:0055085 - transmembrane transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K11446
Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress; GO_component: GO:0070211 - Snt2C complex [Evidence IDA] [PMID 19040720]; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 22842922]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 14562095]; GO_component: GO:0005634 - nucleus [Evidence IDA] [PMID 22842922]; GO_function: GO:0003677 - DNA binding [Evidence IEA]; GO_function: GO:0046872 - metal ion binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_function: GO:0008270 - zinc ion binding [Evidence IEA]; GO_process: GO:0034599 - cellular response to oxidative stress [Evidence IMP] [PMID 23878396]
DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress; GO_component: GO:0005737 - cytoplasm [Evidence IDA] [PMID 14562095]; GO_function: GO:0016887 - ATPase activity [Evidence IDA] [PMID 8444852]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 8444852]; GO_process: GO:0006281 - DNA repair [Evidence IDA,IMP] [PMID 2111448]; GO_process: GO:0006950 - response to stress [Evidence IEA]
Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine; GO_component: GO:0031225 - anchored component of membrane [Evidence IEA]; GO_component: GO:0005618 - cell wall [Evidence IEA,IEA]; GO_component: GO:0005576 - extracellular region [Evidence IEA]; GO_component: GO:0005576 - extracellular region [Evidence IDA] [PMID 10497163]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 10383953]; GO_component: GO:0009277 - fungal-type cell wall [Evidence IDA] [PMID 15781460]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IEA]; GO_function: GO:0004622 - lysophospholipase activity [Evidence IDA,IMP,ISS] [PMID 10497163]; GO_function: GO:0004620 - phospholipase activity [Evidence IEA]; GO_process: GO:0006650 - glycerophospholipid metabolic process [Evidence IDA,IGI,IMP] [PMID 10497163]; GO_process: GO:0016042 - lipid catabolic process [Evidence IEA]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0009395 - phospholipid catabolic process [Evidence IEA]
Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 15608614]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 15326197]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 15608614]; GO_process: GO:0070096 - mitochondrial outer membrane translocase complex assembly [Evidence IMP] [PMID 17974559]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 21825073]; GO_process: GO:0045040 - protein import into mitochondrial outer membrane [Evidence IMP] [PMID 21825074]; GO_process: GO:0015031 - protein transport [Evidence IEA]; GO_process: GO:0006810 - transport [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04716
Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IEA]; GO_component: GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID 10477278]; GO_component: GO:0005789 - endoplasmic reticulum membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence ISM] [PMID 12192589]; GO_component: GO:0016020 - membrane [Evidence IEA,IEA]; GO_function: GO:0003824 - catalytic activity [Evidence IEA]; GO_function: GO:0016787 - hydrolase activity [Evidence IEA]; GO_function: GO:0042392 - sphingosine-1-phosphate phosphatase activity [Evidence TAS] [PMID 11278643]; GO_function: GO:0042392 - sphingosine-1-phosphate phosphatase activity [Evidence IDA] [PMID 9353337]; GO_process: GO:0019722 - calcium-mediated signaling [Evidence IMP] [PMID 11278643]; GO_process: GO:0006629 - lipid metabolic process [Evidence IEA]; GO_process: GO:0030148 - sphingolipid biosynthetic process [Evidence TAS] [PMID 10563329]; GO_process: GO:0006665 - sphingolipid metabolic process [Evidence IEA]
similar to AA sequence:KEGG_Orthology:K04513
GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p); GO_component: GO:0000148 - 1,3-beta-D-glucan synthase complex [Evidence IDA] [PMID 8602515]; GO_component: GO:0005794 - Golgi apparatus [Evidence IDA] [PMID 1918143]; GO_component: GO:0005935 - cellular bud neck [Evidence IDA] [PMID 8195291]; GO_component: GO:0005934 - cellular bud tip [Evidence IDA] [PMID 8195291]; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0000131 - incipient cellular bud site [Evidence IDA] [PMID 8195291]; GO_component: GO:0005622 - intracellular [Evidence IEA]; GO_component: GO:0043332 - mating projection tip [Evidence IDA] [PMID 12660244]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005778 - peroxisomal membrane [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IEA]; GO_component: GO:0005777 - peroxisome [Evidence IDA] [PMID 15596542]; GO_component: GO:0005886 - plasma membrane [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma membrane [Evidence IDA] [PMID 16622836]; GO_function: GO:0005525 - GTP binding [Evidence IEA,IEA]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 11591390]; GO_function: GO:0003924 - GTPase activity [Evidence IDA] [PMID 7962098]; GO_function: GO:0000166 - nucleotide binding [Evidence IEA]; GO_process: GO:0030036 - actin cytoskeleton organization [Evidence IMP] [PMID 15596542]; GO_process: GO:0031532 - actin cytoskeleton reorganization [Evidence IGI,IPI] [PMID 8947028]; GO_process: GO:0007117 - budding cell bud growth [Evidence IGI,IMP] [PMID 8195291]; GO_process: GO:0045807 - positive regulation of endocytosis [Evidence IMP] [PMID 14593073]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IDA,IMP] [PMID 8621575]; GO_process: GO:0090037 - positive regulation of protein kinase C signaling [Evidence IGI,IPI] [PMID 8846785]; GO_process: GO:0008361 - regulation of cell size [Evidence IMP] [PMID 17302939]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IMP] [PMID 8602514]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8602515]; GO_process: GO:0090334 - regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [Evidence IDA,IMP] [PMID 8662910]; GO_process: GO:0060178 - regulation of exocyst localization [Evidence IMP] [PMID 11283608]; GO_process: GO:0060237 - regulation of fungal-type cell wall organization [Evidence IMP] [PMID 8621575]; GO_process: GO:0032880 - regulation of protein localization [Evidence IMP] [PMID 10893184]; GO_process: GO:0032889 - regulation of vacuole fusion, non-autophagic [Evidence IMP] [PMID 11598008]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IEA]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IDA] [PMID 8621575]; GO_process: GO:0007264 - small GTPase mediated signal transduction [Evidence IGI] [PMID 8846785]
Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder; GO_component: GO:0005768 - endosome [Evidence IEA]; GO_component: GO:0005768 - endosome [Evidence IDA] [PMID 14562095]; GO_component: GO:0010008 - endosome membrane [Evidence IEA]; GO_component: GO:0016021 - integral component of membrane [Evidence IEA]; GO_component: GO:0031307 - integral component of mitochondrial outer membrane [Evidence IDA] [PMID 16689936]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 14562095]; GO_component: GO:0005811 - lipid particle [Evidence IDA] [PMID 24868093]; GO_component: GO:0016020 - membrane [Evidence IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IEA,IEA]; GO_component: GO:0005741 - mitochondrial outer membrane [Evidence IDA] [PMID 16407407]; GO_component: GO:0005739 - mitochondrion [Evidence IEA]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_function: GO:0004028 - 3-chloroallyl aldehyde dehydrogenase activity [Evidence ISS] [PMID 16407407]; GO_function: GO:0004029 - aldehyde dehydrogenase (NAD) activity [Evidence IEA]; GO_function: GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity [Evidence IEA]; GO_function: GO:0047770 - carboxylate reductase activity [Evidence IMP] [PMID 22633490]; GO_function: GO:0016491 - oxidoreductase activity [Evidence IEA,IEA]; GO_function: GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Evidence IEA]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IEA]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IC] [PMID 16407407]; GO_process: GO:0006081 - cellular aldehyde metabolic process [Evidence IMP] [PMID 22633490]; GO_process: GO:0008152 - metabolic process [Evidence IEA]; GO_process: GO:0055114 - oxidation-reduction process [Evidence IEA,IEA]
similar to AA sequence:KEGG_Orthology:K12844
Splicing factor; component of the U4/U6-U5 snRNP complex; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IEA]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10377396]; GO_component: GO:0046540 - U4/U6 x U5 tri-snRNP complex [Evidence IDA] [PMID 10449419]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 14576278]; GO_component: GO:0005739 - mitochondrion [Evidence IDA] [PMID 16823961]; GO_component: GO:0005634 - nucleus [Evidence IEA,IEA]; GO_component: GO:0030529 - ribonucleoprotein complex [Evidence IEA]; GO_component: GO:0005681 - spliceosomal complex [Evidence IEA]; GO_function: GO:0003723 - RNA binding [Evidence IEA]; GO_function: GO:0003674 - molecular_function [Evidence ND]; GO_process: GO:0008380 - RNA splicing [Evidence IEA]; GO_process: GO:0006397 - mRNA processing [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IEA]; GO_process: GO:0000398 - mRNA splicing, via spliceosome [Evidence IPI] [PMID 10377396]; GO_process: GO:0000387 - spliceosomal snRNP assembly [Evidence IDA,IMP] [PMID 9199293]; GO_process: GO:0000244 - spliceosomal tri-snRNP complex assembly [Evidence IEA]