Komagataella phaffii GS115 chromosome 3, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
Genome sequence of the recombinant protein production host Pichia pastoris
Submitted (17-FEB-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (05-MAY-2009) Callewaert N., Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB) / Gent University, Technologiepark 927, Ghent, 9052, BELGIUM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FN392321.\nContact: Nico Callewaert\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent Technologiepark\n927, B-9052 Gent, Belgium\nTel: (32)93313630\nFax: (32)93313609\nEmail: nico.callewaert@dmbr.vib-UGent.be\n----------- sequencing/assembly\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent -----------\nannotation\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent\n\nLaboratory for Bioinformatics and Evolutionary Genomics VIB\nDepartment of Plant Systems Biology, UGent\nWeb site: http://bioinformatics.psb.ugent.be/\nBioinformatics Online Genome Annotation System (BOGAS):\nhttp://bioinformatics.psb.ugent.be/webtools/bogas/ -----------\n* NOTE: finishing of chromosomes in process\n* Final curation of the annotation in progress.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
NADPH-dependent medium chain alcohol dehydrogenase
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regi
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane
Putative transporter, member of the sugar porter family
Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitat
S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial ca
Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis path
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochond
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the o
Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting
E3 ubiquitin ligase of the hect-domain class
Protein required for S phase progression and telomere homeostasis, forms an alternative replication
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling en
Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl grou
Mitochondrial intermembrane space cysteine motif protein
Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron h
Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane p
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleot
Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2
RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both
Component of the RSC chromatin remodeling complex
Diacylglycerol kinase, localized to the endoplasmic reticulum (ER)
Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylat
Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start
Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2)
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosph
Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation
Protein involved in bud site selection during bipolar budding
Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid inv
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, whi
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucle
Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YE
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as pa
Profilin, actin-and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton
Nucleolar protein involved in pre-rRNA processing
Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into m
Component of the inositol phosphorylceramide synthase
Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required f
One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC)
Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall bet
Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein
Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome
Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene
Protein kinase with similarityto serine/threonine protein kinase Ypk1p
SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p
Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-termin
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in th
GTP-binding protein of the ras superfamily required for bud site selection
Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of
Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into
Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex
ER localized, heme-binding peroxidase involved in the degradation of heme
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter
Secretory vesicle-associated Rab GTPase essential for exocytosis
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate ac
Glucose-repressible protein kinase involved in signal transduction during cell proliferation in resp
Subunit of the RNA polymerase II mediator complex
Diaminohydroxyphoshoribosylaminopyrimidine deaminase
RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III
Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis
Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport
O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynth
Co-chaperone that binds to Hsp82p and activates its ATPase activity
Protein required for establishment and maintenance of sister chromatid condensation and cohesion
Essential subunit of the histone deacetylase Rpd3S complex
Mitochondrial ornithine acetyltransferase
Mitochondrial inner membrane citrate transporter
D-serine dehydratase (aka D-serine ammonia-lyase)
Diacylglycerol pyrophosphate (DGPP) phosphatase
Protein involved in 5.8S rRNA processing
Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
Cytosolic protein required for sporulation
Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex
Outer kinetochore protein required for chromosome stability
Type 2A-related serine-threonine phosphatase
Mitogen-activated protein (MAP) kinase kinase kinase
mitochondrial 54S ribosomal protein YmL49
non-ATPase regulatory subunit of the 26S proteasome lid
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex
ATPase involved in protein folding and the response to stress
Proliferating cell nuclear antigen (PCNA)
Catalytic subunit of N-terminal acetyltransferase of the NatC type
Essential protein required for biogenesis of 40S (small) ribosomal subunit
Plasma membrane associated protein phosphatase involved in the general stress response
Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p
Component of the Sin3p-Rpd3p histone deacetylase complex
Palmitoyltransferase with autoacylation activity
Component of the chromatin assembly complex (with Rlf2p and Msi1p)
Subunit of a histone deacetylase complex
Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p)
Putative protein with similarity to the allantoate permease (Dal5p)
RNA terminal phosphate cyclase-like protein
Protein required for sorting proteins to the vacuole
Non-essential hydrolase involved in mRNA decapping
6-phosphogluconate dehydrogenase (decarboxylating)
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patch
Protein component of the small (40S) ribosomal subunit
Para hydroxybenzoate: polyprenyl transferase
Essential protein possibly involved in secretion
Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)
Protein required for proper cell fusion and cell morphology
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p
Component of the GARP (Golgi-associated retrograde protein) complex
Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli
Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex)
UBX (ubiquitin regulatory X) domain-containing protein
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron c
Farnesyl-diphosphate farnesyl transferase (squalene synthase)
Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in
Subunit of the telomeric Ku complex (Yku70p-Yku80p)
Protein involved in bud-site selection and required for axial budding pattern
Subunit of cleavage polyadenylation factor (CPF)
Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen
Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2
Subunit of the core complex of translation initiation factor 3(eIF3)
ATPase required for the release of Sec17p
Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p)
Serine/threonine protein kinase involved in regulation of exocytosis
Putative SCF-ubiquitin ligase F-box protein
Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase
Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p
P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis
Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI)
Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose
Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation
Cytoplasmic and mitochondrial glycyl-tRNA synthase
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)
Peptidyl-prolyl cis-trans isomerase (cyclophilin)
Orotidine-5'-phosphate (OMP) decarboxylase
Mitochondrial intermembrane space protein
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome
Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I
Catalytic epsilon subunit of the translation initiation factor eIF2B
Component of the septin ring of the mother-bud neck that is required for cytokinesis
Putative transcription factor containing a zinc finger
Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane
Protein with a potential role in pre-rRNA processing
Zinc-finger inhibitor of HO transcription
Putative metalloprotease with similarity to the zinc carboxypeptidase family
Member of an oxysterol-binding protein family with seven members in S. cerevisiae
Putative membrane protein of unknown function involved in Mn2+ homeostasis
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)
Protein involved in homologous recombination in mitochondria and in transcription regulation in nucl
Protein required for cytochrome c oxidase assembly
Protein required for transport of flavin adenine dinucleotide (FAD)
Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC)
Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies
Subunit of tRNA (1-methyladenosine) methyltransferase
Subunit (90 kDa) of TFIID and SAGA complexes
Glycolytic enzyme phosphoglucose isomerase
Essential, non-ATPase regulatory subunit of the 26S proteasome
Essential component of the Arp2/3 complex
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase
Mitochondrial ribosomal protein of the large subunit
Acyl-CoA:sterol acyltransferase, isozyme of Are1p
Putative metalloprotease of the mitochondrial inner membrane
Aspartic beta semi-aldehyde dehydrogenase
mitochondrial 54S ribosomal protein MRPL1
Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex
Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p
Putative alanine transaminase (glutamic pyruvic transaminase)
Conserved phosphoesterase domain-containing protein
Bud-specific protein with a potential role in membrane trafficking
Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type
Low-affinity phosphate transporter of the vacuolar membrane
RNA-dependent ATPase in the DEAH-box family
Zinc finger transcriptional activator of the Zn2Cys6 family
Mg<sup&gt2+</sup&gt-dependent phosphatidate (PA) phosphatase
Subunit of the alpha-1,6 mannosyltransferase complex
High-affinity zinc transporter of the plasma membrane
Permease of basic amino acids in the vacuolar membrane
putative mitochondrial 37S ribosomal protein SWS2
Essential component of the nuclear pore complex
Protein with a role in regulation of Ty1 transposition
Saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER
Peripheral mitochondrial membrane protein involved in mitochondrial protein import
Ubiquitin-protein ligase of the ER/nuclear envelope
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA)
Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p)
Alpha' catalytic subunit of casein kinase 2
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation
Vacuolar membrane protein of unknown function
UDP-glucose:dolichyl-phosphate glucosyltransferase
ADP-ribosylation factor GTPase activating protein (ARF GAP)
Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway
Mitochondrial translation elongation factor Tu
Beta subunit of the translation initiation factor eIF2B
Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin
Protein involved in nutritional control of the cell cycle
Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing
Cyclin associated with protein kinase Kin28p
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase
Mitochondrial glycerol-3-phosphate dehydrogenase
3'-5' exoribonuclease involved in rRNA processing
Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
Protein that contains a Phox homology (PX) domain and binds phosphoinositides
Component of the TOM (translocase of outer membrane) complex
Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p
Component of yeast cortical actin cytoskeleton
Homeodomain-containing transcriptional repressor of PTR2
F-box protein containing five copies of the WD40 motif, controls cell cycle function
Translation initiation factor eIF4A, identical to Tif1p
Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate
Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex
Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit
Protein serine/threonine phosphatase with similarity to human phosphatase PP5
Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme
Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p
Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase)
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity
Transcriptional repressor involved in response to pH and in cell wall construction
Conserved nuclear protein required to establish sister-chromatid pairing during S-phase
Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis
Putative serine type carboxypeptidase with a role in phytochelatin synthesis
Tryptophan synthase involved in tryptophan biosynthesis
Beta subunit of the CAAX farnesyltransferase (FTase)
Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase
Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF
Subunit of the SF3a splicing factor complex, required for spliceosome assembly
Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1-cotransporter family
RNA helicase in the DEAD-box family, necessary for prespliceosome formation
Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamine pyrophosphate
Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C
Phosphatidylinositol/phosphatidylcholine transfer protein
ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for
Putative mitochondrial aconitase isozyme
GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns
Mitochondrial translational activator of the COB mRNA
17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing
Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
Cytoplasmic thioredoxin isoenzyme of the thioredoxin system
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway
D-lactate dehydrogenase, located in the mitochondrial matrix
UDP-N-acetylglucosamine pyrophosphorylase
Protein that interacts with the karyopherin Srp1p
RNA exonuclease, required for U4 snRNA maturation
Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae
Essential nucleolar protein that is a component of the SSU (small subunit) processome
Protein with similarity to Emp24p and Erv25p, member of the p24 family
Molybdenum cofactor biosynthesis protein
E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p
Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase
Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation
Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase)
Mitochondrial inner membrane Mg(2+) channel
Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p)
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal protein
Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors
Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex
Putative divalent metal ion transporter involved in iron homeostasis
ubiquitin-40S ribosomal protein S31 fusion protein
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis
Phosphotyrosine-specific protein phosphatase
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone
DNA ligase required for nonhomologous end-joining (NHEJ)
Component of serine palmitoyltransferase
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C)
TFIIE small subunit, involved in RNA polymerase II transcription initiation
Nucleolar DEAD-box protein required for ribosome assembly and function
Protein involved in DNA mismatch repair and crossing-over during meiotic recombination
Alpha subunit of the oligosaccharyltransferase complex of the ER lumen
Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain
Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism
Cytochrome c oxidase assembly protein/Cu2+ chaperone
Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase
Ser/Thr kinase involved in transcription and stress response
Mitochondrial and cytoplasmic valyl-tRNA synthetase
Splicing factor, component of the U4/U6-U5 snRNP complex
Nucleolar protein, forms a complex with Nop14p
Beta subunit of Type II geranylgeranyltransferase
Second largest subunit of DNA polymerase II (DNA polymerase epsilon)
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p)
Protein involved in the regulation of cell wall synthesis
Putative mitochondrial transport protein
Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway
Subunit of the eukaryotic translation initiation factor 3 (eIF3)
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis
Nucleolar protein, component of the small subunit (SSU) processome
Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis
Mitochondrial ribosomal protein of the small subunit
Protein kinase of the PAK/Ste20 kinase family
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase
Protein involved in the organization of the actin cytoskeleton
Large subunit of carbamoyl phosphate synthetase
Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p
Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage
ATP-dependent RNA helicase of the DEAD box family
Subunit g of the mitochondrial F1F0 ATP synthase
Protein with similarity to human cystinosin
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p)
Type II myosin heavy chain, required for wild-type cytokinesis and cell separation
Essential component of the nuclear pore complex, which mediates nuclear import and export
Gamma subunit of the translation initiation factor eIF2
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA)
Phosphatidylinositol transfer protein (PITP)
Lyso-phosphatidylcholine acyltransferase
Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism
Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing
Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p)
Subunit of a complex with Rad50p and Xrs2p (MRX complex)
Smaller subunit of the mitochondrial processing protease (MPP)
Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor
Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase)
Single-stranded DNA-binding protein essential for mitochondrial genome maintenance
Protein with a potential role in actin cytoskeletal organization
Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase)
Serine-threonine protein kinase that is part of a glucose-sensing system
Mitochondrial inner membrane protein required for normal mitochondrial morphology
One of six ATPases of the 19S regulatory particle of the 26S proteasome
Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis
Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA
Dimeric hypoxanthine-guanine phosphoribosyltransferase
Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoprotein
Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor
Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome
Homoserine kinase, conserved protein required for threonine biosynthesis
Strand exchange protein, forms a helical filament with DNA that searches for homology
Putative transcription factor, has homolog in Kluyveromyces lactis
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity
Mitochondrial protein, forms a heterodimer complex with Mss1p
Acetyltransferase required for the establishment of sister chromatid cohesion
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis
Polyamine oxidase, converts spermine to spermidine
Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursor
Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function
Protein required for beta-1,6 glucan biosynthesis
Phosphoinositide binding protein required for vesicle formation in autophagy
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase
Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family
Subunit of the origin recognition complex, which directs DNA replication
Coproporphyrinogen III oxidase, an oxygen requiring enzyme
mitochondrial 37S ribosomal protein RSM10
2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides
Triose phosphate isomerase, abundant glycolytic enzyme
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol
mitochondrial 54S ribosomal protein YmL38/YmL34
Glycoprotein involved in cell wall beta-glucan assembly
Bifunctional enzyme exhibiting indole-3-glycerol-phosphate synthase and anthranilate synthase activi
cAMP-dependent protein kinase catalytic subunit
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA)
Transcription factor involved in cell-type-specific transcription and pheromone response
ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport
One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p)
RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci
Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)
Serine hydrolase with sequence similarity to monoglyceride lipase (MGL)
t-SNARE required for ER membrane fusion and vesicular traffic
Essential protein involved in the processing of pre-rRNA and the assembly of 60S ribosomal subunit
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC)
Cytochrome c1, component of the mitochondrial respiratory chain
Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A
Glucosyl transferase, involved in N-linked glycosylation
General repressor of transcription, forms complex with Cyc8p
Putative nicotinamide N-methyltransferase
Essential, conserved, cytoplasmic ATPase
Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate
Cytosolic and mitochondrial glutathione oxidoreductase
Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)
Protein required for growth of cells lacking the mitochondrial genome
Resident protein of the ER membrane that plays a central role in ER-associated protein degradation
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent
NAD(+)-dependent glutamate synthase (GOGAT)
S-(hydroxymethyl)glutathione dehydrogenase
Negative regulatory subunit of the protein phosphatase 1 Ppz1p
Nucleolar protein required for 60S ribosomal subunit biogenesis
Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase)
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector
Catalytic component of the exosome, involved in RNA processing and degradation
Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p
Small subunit of the clathrin-associated adaptor complex AP-2
Translation initiation factor eIF-5A, promotes formation of the first peptide bond
Translation initiation factor eIF-4B, has RNA annealing activity
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein
Protein kinase of the Mitotic Exit Network
Membrane protein of the plasma membrane and ER
Protein with putative serine active lipase domain
Essential, non-ATPase regulatory subunit of the 26S proteasome lid
Subunit of the nuclear pore complex (NPC)
Translation elongation factor EF-1 gamma
Glycerol proton symporter of the plasma membrane
Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing
Subunit of the anaphase-promoting complex/cyclosome (APC/C)
U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49
Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by meth
Protein involved in cis-Golgi membrane traffic
Vacuolar aspartyl protease (proteinase A)
Sporulation specific protein that localizes to the spore wall
Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p
Protein involved in nuclear migration, part of the dynein/dynactin pathway
Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p)
Phosphoesterase involved in downregulation of the unfolded protein response
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation
Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p
Component of the pre-60S pre-ribosomal particle
Serine-threonine kinase and endoribonuclease
Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole
Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis
Protein that localizes to the nucleus and is involved in transcription regulation
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)
DNA ligase found in the nucleus and mitochondria
Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P
mitochondrial 37S ribosomal protein RSM19
Essential protein involved in ribosome biogenesis
Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate
putative mitochondrial 37S ribosomal protein MRPS12
Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p
Protein with similarity to mammalian developmentally regulated GTP-binding protein
6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway
Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3
Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism
Protein involved in programmed cell death
Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine
mitochondrial 54S ribosomal protein YmL39
Adenine phosphoribosyltransferase, catalyzes the formation of AMP
Cytoplasmic light chain dynein, microtubule motor protein
Subunit of the oligosaccharyltransferase complex of the ER lumen
mitochondrial 37S ribosomal protein MRP4