Komagataella phaffii GS115 chromosome 2, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
Genome sequence of the recombinant protein production host Pichia pastoris
Submitted (17-FEB-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (05-MAY-2009) Callewaert N., Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB) / Gent University, Technologiepark 927, Ghent, 9052, BELGIUM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FN392320.\nContact: Nico Callewaert\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent Technologiepark\n927, B-9052 Gent, Belgium\nTel: (32)93313630\nFax: (32)93313609\nEmail: nico.callewaert@dmbr.vib-UGent.be\n----------- sequencing/assembly\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent -----------\nannotation\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent\n\nLaboratory for Bioinformatics and Evolutionary Genomics VIB\nDepartment of Plant Systems Biology, UGent\nWeb site: http://bioinformatics.psb.ugent.be/\nBioinformatics Online Genome Annotation System (BOGAS):\nhttp://bioinformatics.psb.ugent.be/webtools/bogas/ -----------\n* NOTE: finishing of chromosomes in process\n* Final curation of the annotation in progress.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low
Putative protein-methionine-R-oxide reductase
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has sim
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize sid
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use
2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight
Non-essential protein of unknown function, contains ATP/GTP-binding site motif A
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that incl
Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the
Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcripti
Nitrilase, member of the nitrilase branch of the nitrilase superfamily
Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p
Protein with similarity to ATP-binding cassette (ABC) transporter family members
Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchan
Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human T
Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to urac
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u
Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secre
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyze
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase
JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri-and dimethy
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin
Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p a
Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved
N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stre
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase t
Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite
Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response
Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein a
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of
Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochond
Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation an
Protein possibly involved in a post-Golgi secretory pathway
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex wit
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step
tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulat
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from
Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair bo
Nucleosome remodeling factor that functions in regulation of transcription elongation
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation
Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between th
Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues
B-type cyclin involved in cell cycle progression
Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobu
Fructose-2,6-bisphosphatase, required for glucose metabolism
Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP
Small rho-like GTPase, essential for establishment and maintenance of cell polarity
Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol
Sterol regulatory element binding protein, induces transcription of sterol transport and biosyntheti
Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p)
GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mut
Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugatio
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of
Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosy
Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
Elongation factor 2 (EF-2), also encoded by EFT1
RNA polymerase II second largest subunit B150, part of central core
mitochondrial 54S ribosomal protein YmL41
Proline permease, required for high-affinity transport of proline
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytos
Helix-hairpin-helix protein, involved in DNA repair and replication fork stability
Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus expo
Mitochondrial ribosomal protein of the small subunit
ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding i
Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms th
Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of ir
Subunit of the RNA polymerase II mediator complex
Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as
Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylat
Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA
Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+
Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional
UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis
v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
Histidine kinase osmosensor that regulates a MAP kinase cascade
Catalytic subunit of DNA polymerase delta
Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins
Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis
putative transporter of the mitochondrial inner membrane
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-gl
Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1
tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulate
Protease involved in the processing of killer toxin and alpha factor precursor
ATP (CTP):tRNA-specific tRNA nucleotidyltransferase
S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin
Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitoch
Protein required for respiratory growth and stability of the mitochondrial genome
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-Co
Component of the RSC chromatin remodeling complex
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic c
Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excisio
D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid
Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein tra
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated prote
Subunit of the Hat1p-Hat2p histone acetyltransferase complex
Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in tel
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p
One of two large regulatory subunits of ribonucleotide-diphosphate reductase
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to prote
Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome
DNA binding protein with similarity to the S. pombe Snt2 protein
Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is
Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator
Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, an
Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis
U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRN
RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
Zinc cluster transcriptional activator involved in conferring resistance to ketoconazole
Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochr
DNA helicase involved in rDNA replication and Ty1 transposition
Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene e
Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of m
Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM)
Na+/Pi cotransporter, active in early growth phase
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups i
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate
Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
Mitochondrial translation initiation factor 2
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase)
Kinesin-related motor protein involved in mitotic spindle positioning
Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme
Hypothetical protein, peroxisomal 2,4-dienoyl-CoA reductase
N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2
Nucleoside transporter with broad nucleoside selectivity
Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p
Catalytic subunit of 1,3-beta-D-glucan synthase
Mitochondrial outer membrane protein with similarity to Tom70p
Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase
Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA
Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine
Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme
Protein involved in postreplication repair
Triacylglycerol lipase of the lipid particle, responsible for all the TAG lipase activity of the lip
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenanceof the mitoc
Late endosomal protein involved in late endosome to vacuole trafficking
Essential 113kDa subunit of the exocyst complex
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase
Voltage-gated high-affinity calcium channel
Putative catalytic subunit of a class II histone deacetylase complex
UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in GPI synthesis
Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate
Bifunctional enzyme with alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase
Protein that binds tRNA and methionyl-and glutamyl-tRNA synthetases (Mes1p and Gus1p)
Protein containing a UCS (UNC-45/CRO1/SHE4) domain
Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A
Oligomeric mitochondrial matrix chaperone
Palmitoyl transferase involved in protein palmitoylation
putative cochaperone, regulates activity of Cyr1p (adenylyl cyclase)
Mitotic spindle midzone localized microtubule-associated protein (MAP) family member
Zeta-crystallin homolog, found in the cytoplasm and nucleus
Protein required for assembly of cytochrome c oxidase
Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzym
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p
Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p
Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription
Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex
Palmitoylated, plasma membrane-bound casein kinase I isoform
Cystathionine beta-lyase, converts cystathionine into homocysteine
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane
putative mRNA N6-adenosine methyltransferase
Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton
Essential protein required for chromosome condensation
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3
Component of the Swr1p complex that incorporates Htz1p into chromatin
Actin-and formin-interacting protein, involved in actin cable nucleation and polarized cell growth
Reverse transcriptase subunit of the telomerase holoenzyme
Subunit of tRNA-specific adenosine-34 deaminase
Putative GTPase, member of the Obg family
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex
Putative ATP-dependent RNA helicase of the DEAD-box family
Signal recognition particle (SRP) receptor-alpha subunit
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine
mitochondrial 37S ribosomal protein MRPS28
Protein involved in minichromosome maintenance
Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide
Protein with similarity to the p27 subunit of mammalian proteasome modulator
Ubiquitin-like protein with weak sequence similarity to ubiquitin
DNA polymerase III (delta) subunit, essential for cell viability
Mitochondrial methionyl-tRNA synthetase (MetRS)
Protein that localizes to chromatin and has a role in regulation of histone gene expression
Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis
Serine/threonine protein phosphatase Z, isoform of Ppz2p
Putative transporter (DHA1 family) of multidrug resistance transporter
Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane
Essential protein involved in 60S ribosome maturation
Membrane protein involved in zinc metabolism, member of the four-protein IZH family
Alpha-isopropylmalate synthase (2-isopropylmalate synthase)
Protein kinase that forms a complex with Mad1p and Bub3p
Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex
Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria
Acireductone dioxygenease involved in the methionine salvage pathway
Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sa
Putative high affinity iron transporter involved in transport of intravacuolar stores of iron
One of two nearly identical (see HTB1) histone H2B subtypes
One of two nearly identical (see also HTA1) histone H2A subtypes
Essential subunit of the COMPASS (Set1C) complex
Short-lived chaperone required for correct maturation of the 20S proteasome
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p)
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis
DNA helicase involved in telomere formation and elongation
Mitochondrial ribosomal protein of the large subunit
GTP binding protein (mammalian Ranp homolog)
Component of the U1 snRNP complex required for pre-mRNA splicing
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly
Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh1
Protein involved in ER-to-Golgi transport
Subunit of TORC1, a rapamycin-sensitive complex involved in growth control
Mitochondrial protein of the mitochondrial carrier family
Metalloendopeptidase of the mitochondrial inner membrane
Triacylglycerol lipase involved in triacylglycerol mobilization and degradation
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-termina
Mitochondrial alcohol dehydrogenase isozyme III
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates
dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi
Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator
ubiquitin-60S ribosomal protein L40 fusion protein
Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p
Nitrogen catabolite repression transcriptional regulator
Protein whose overexpression suppresses growth defect of mutants lacking protein kinase A activity
Essential NTPase required for small ribosome subunit synthesis
Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2)
Single-domain racemase, possibly non-specific due to the lack of the second domain
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis
B subunit of DNA polymerase alpha-primase complex
Plasma membrane protein that may be involved in osmotolerance
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)
Transcription factor involved in regulation of cell cycle progression from G1 to S phase
Homodimeric Zn2Cys6 zinc finger transcription factor
Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
Member of the Sir2 family of NAD(+)-dependent protein deacetylases
Kinetochore checkpoint WD40 repeat protein
Nuclear protein that contains a SET-domain
AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase
3-oxoacyl-[acyl-carrier-protein] reductase
2'-O-methyltransferase responsible for modification of tRNA at position 4
Ornithine transporter of the mitochondrial inner membrane
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi
Protein of the mitochondrial outer surface
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex
Membrane protein that interacts with Yip1p to mediate membrane traffic
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation
Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis
Protein involved in 20S proteasome assembly
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p
Essential component of the Arp2/3 complex
PIK-related protein kinase and rapamycin target
Protein required, with binding partner Psr1p, for full activation of the general stress response
Protein with similarity to human cystinosin, which is a H(+)-driven transporter
Protein that activates Urm1p before its conjugation to proteins (urmylation)
putative U3 snoRNP protein involved in maturation of pre-18S rRNA
Protein involved in error-free postreplication DNA repair
Subunit of the origin recognition complex
AAA-type ATPase that is regulated by Vta1p
Methyltransferase required for synthesis of diphthamide
Regulatory subunit of acetolactate synthase
Cytosolic NADP-specific isocitrate dehydrogenase
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster
Guanine nucleotide exchange factor (GEF)
Subunit (61/68 kDa) of TFIID and SAGA complexes
Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p)
Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II
Coronin, cortical actin cytoskeletal component
Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide
Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1)
Putative helicase with limited sequence similarity to human Rb protein
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)
Nucleolar protein, specifically associated with the U3 snoRNA
Activating gamma subunit of the AMP-activated Snf1p kinase complex
Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter
Essential 18S rRNA dimethylase (dimethyladenosine transferase)
Nuclear pore protein involved in nuclear export of pre-tRNA
Subunit of heteropentameric Replication factor C (RF-C)
mitochondrial 54S ribosomal protein YmL27
Glutamine-fructose-6-phosphate amidotransferase
Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p)
Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesion
Microtubule effector required for tubulin heterodimer formation
Catalytic subunit of type 1 serine/threonine protein phosphatase
Signal recognition particle (SRP) receptor beta subunit
Bifunctional chorismate synthase and flavin reductase
Upstream serine/threonine kinase for the SNF1 complex
Protein serine/threonine kinase required for vesicle formation in autophagy
Protein implicated in Mms22-dependent DNA repair during S phase
Peripheral membrane protein required for vesicular transport between ER and Golgi
Protein component of the H/ACA snoRNP pseudouridylase complex
Acetate transporter required for normal sporulation
Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
Mitochondrial cruciform cutting endonuclease
Nucleolar protein, component of the small subunit (SSU) processome
Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis
Large subunit of the nuclear mRNA cap-binding protein complex
F-box protein required for G1/S and G2/M transition
Protein involved in negative regulation of transcription of iron regulon
Vacuolar membrane protein involved in vacuolar polyphosphate accumulation
Essential protein of the mitochondrial intermembrane space (IMS)
Scaffold protein responsible for pre-autophagosomal structure organization
Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p
Mitochondrial inner membrane protein with similarity to Mdm32p
Protein involved in the transcription of 35S rRNA genes by RNA polymerase I
Tryptophan synthase involved in tryptophan biosynthesis
Xanthine-guanine phosphoribosyl transferase
Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis
Vacuolar ATPase V0 domain subunit c', involved in proton transport activity
Essential protein involved in transcription regulation
Putative protein kinase that exhibits Akr1p-dependent palmitoylation
Constituent of the mitochondrial import motor associated with the presequence translocase
Protein with a role in UDP-galactose transport to the Golgi lumen
Acyltransferase that catalyzes diacylglycerol esterification
Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol
Catalytic subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis
Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase
GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation
Protein that recognizes and binds damaged DNA during nucleotide excision repair
putative serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), wh
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway
Putative positive regulator of mannosylphosphate transferase (Mnn6p)
Putative transporter, member of the SLC10 carrier family
UDP-N-acetyl-glucosamine-1-P transferase
Essential light chain for Myo1p, light chain for Myo2p
Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex
Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation
Allantoicase, converts allantoate to urea and ureidoglycolate
Subunit of the mitochondrial F1F0 ATP synthase
Cystathionine gamma-synthase, converts cysteine into cystathionine
Alpha-1,2-mannosidase involved in ER quality control
Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC)
Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER)
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic
Protein involved in mRNA export coupled transcription activation
General transcriptional co-repressor, acts together with Tup1p
2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p
Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway
Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate
Protein with a role in cellular adhesion and filamentous growth
Subunit of TRAPP (transport protein particle)
NAD-dependent arabinose dehydrogenase, involved in biosynthesis of erythroascorbic acid
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway
Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs
Glucosidase II catalytic subunit required for normal cell wall synthesis
Homeodomain-containing transcriptional repressor
Mu3-like subunit of the clathrin associated protein complex (AP-3)
Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde prote
Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. co
Protein that activates transcription through interaction with DNA-bound Snf
5' to 3' DNA helicase, involved in nucleotide excision repair and transcription
Subunit of the HIR complex, a nucleosome assembly complex
Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p)
Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p)
Gluconolactonase putatively involved in growth regulation
Involved in exosome mediated 3' to 5' mRNA degradation & translation inhibition of non-poly(A) mRNAs
RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III
Transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers
Regulatory subunit of the Atg1p signaling complex
Subunit 2 of the ubiquinol cytochrome-c reductase complex
Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex
Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO)
Splicing factor, component of the U4/U6-U5 snRNP complex
mitochondrial 54S ribosomal protein YmL10/YmL18
Subunit of the condensin complex, which reorganizes chromosomes during cell division
Beta3-like subunit of the yeast AP-3 complex
Protein with a role in maintenance of cellular integrity
J-protein co-chaperone of the mitochondrial import motor
Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain
Mitochondrial elongation factor involved in translational elongation
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of L-serine and L-threonine
Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle
Protein involved in clathrin cage assembly
Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase
Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein
Essential iron-sulfur cluster binding protein localized in the cytoplasm
Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes
Thiol peroxidase that functions as a hydroperoxide receptor
Peptidylprolyl-cis/trans-isomerase (PPIase)
Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrate
Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor
Mitochondrial ribosomal component of the small subunit
Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin
Protein with a role in urmylation and in invasive and pseudohyphal growth
Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis
Component (70 kDa) of the TOM (translocase of outer membrane) complex
DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA
Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing
Mitochondrial inner membrane carnitine transporter
Protein involved in G1 cell cycle arrest in response to pheromone
Catalytic subunit of the DNA polymerase I alpha-primase complex
GTP-binding protein of the ras superfamily required for bud site selection
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen
Vacuolar transporter, exports large neutral amino acids from the vacuole
Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid
Conserved zinc-finger domain protein involved in pre-mRNA splicing
Transaldolase, enzyme in the non-oxidative pentose phosphate pathway
Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha
Protein kinase involved in the response to oxidative and osmotic stress
Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase)
Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway
Nucleoporin involved in nucleocytoplasmic transport
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p
Actin-binding protein of the cortical actin cytoskeleton
Phosphomevalonate kinase, an essential cytosolic enzyme
Prephenate dehydrogenase involved in tyrosine biosynthesis
Soluble GTPase with a role in regulation of membrane traffic
Glycerophosphocholine (GroPCho) phosphodiesterase
3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan
Dipeptidyl aminopeptidase, Golgi integral membrane protein
RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
Protein involved in DNA repair, related to the human CSA protein
Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p
Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis
Multifunctional enzyme of the folic acid biosynthesis pathway
Plasma membrane ATP binding cassette (ABC) transporter
Cyclin-dependent protein kinase regulatory subunit and adaptor
Genome integrity checkpoint protein and PI kinase superfamily member
TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c
Protein containing a CUE domain that binds ubiquitin
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p
Cytochrome c1 heme lyase, involved in maturation of cytochrome c1
Arginase, responsible for arginine degradation
Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome
mitochondrial 37S ribosomal protein RSM24
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p)
Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitat
Plasma membrane sulfite pump involved in sulfite metabolism
Delta subunit of the translation initiation factor eIF2B
B-type regulatory subunit of protein phosphatase 2A (PP2A)
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p)
GPI-anchored cell wall protein of unknown function
Essential structural subunit of the nuclear pore complex (NPC)
3-ketoacyl-CoA thiolase with broad chain length specificity
ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex
Bud neck-localized, SH3 domain-containing protein required for cytokinesis
DNA repair methyltransferase (6-O-methylguanine-DNA methylase)
Alkaline dihydroceramidase, involved in sphingolipid metabolism
Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
Cell-wall L-asparaginase II, involved in asparagine catabolism
Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase
Subunit of the HIR complex, a nucleosome assembly complex involved in histone gene transcription
Mitochondrial tryptophanyl-tRNA synthetase
Component of the SSU processome, which is required for pre-18S rRNA processing
mitochondrial 54S ribosomal protein YmL16
mitochondrial 54S ribosomal protein YmL9
RING finger protein that interacts with the arginine methyltransferase Hmt1p
Threonyl-tRNA synthetase, essential cytoplasmic protein
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate
Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase)
Component of the TRAPP (transport protein particle) complex
Nuclear encoded protein required for translation of COX1 mRNA
Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant
One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases
3'--&gt5' exonuclease and endonuclease with a possible role in apoptosis
Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in
Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p
Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p)
Essential component of the Sorting and Assembly Machinery of the mitochondrial outer membrane
Putative phosphopantothenoylcysteine synthetase (PPCS)
Putative mannosyltransferase involved in protein glycosylation
One of two identical histone H4 proteins (see also HHF2)
One of two identical histone H3 proteins (see also HHT2)
Tyrosine phosphatase that plays a role in actin filament organization and endocytosis
Cyclin-like component of the RNA polymerase II holoenzyme
Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole
Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcri
Protein involved in pre-mRNA splicing, component of a complex containing Cef1p
RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1)
Subunit of a Golgi mannosyltransferase complex
Single-stranded DNA endonuclease (with Rad10p)
Isozyme of methylenetetrahydrofolate reductase
Cytoplasmic serine/threonine protein kinase
Mu2-like subunit of the clathrin associated protein complex (AP-2)
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP
Protein that interacts with mitotic cyclin Clb2p
mitochondrial 37S ribosomal protein RSM25
Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet)
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p
Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface
Cell wall protein that contains a putative GPI-attachment site
Component of the Trk1p-Trk2p potassium transport system
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase)
One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine
General transcription elongation factor TFIIS
Cleavage and polyadenylation factor I (CF I) component
t-SNARE protein important for fusion of secretory vesicles with the plasma membrane
Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1
Essential protein involved in maturation of 18S rRNA
ATPase component of the RSC chromatin remodeling complex
Presequence translocase-associated motor subunit
Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p
Conserved protein required for assembly of subunits of mitochondrial F1F0 ATP synthase
ER associated glutathione S-transferase capable of homodimerization
Boron efflux transporter of the plasma membrane
Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis
Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway
Mannosyltransferase involved in N-linked protein glycosylation
Serine-threonine protein kinase that is part of a glucose-sensing system
Essential constituent of the mitochondrial inner membrane presequence translocase
Protein involved in excretion of putrescine and spermidine
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome
Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly
Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates
Integral inner mitochondrial membrane protein
Chaperone that specifically facilitates the assembly of cytochrome c oxidase
ADP-ribosylation factor, GTPase of the Ras superfamily
mitochondrial 37S ribosomal protein MRPS5
Repressible alkaline phosphatase, a glycoprotein localized to the vacuole
Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex)
Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimul
Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli
GTPase of the Ras superfamily required to recruit Arl1p to the Golgi
Putative phosphatidylinositol transfer protein (PITP)
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis
Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism
Nuclear actin-related protein involved in chromatin remodeling
CAP (cyclase-associated protein) subunit of adenylyl cyclase complex
Plasma membrane multidrug transporter of the major facilitator superfamily
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication
NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase
Essential abundant protein involved in regulation of transcription
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligib
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p
Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose
Putative protein with similarity to the allantoate permease (Dal5p) subfamily
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase)
Specificity factor required for Rsp5p-dependent ubiquitination
Serine/threonine protein kinase, subunit of the transcription factor TFIIH
Cell-cycle checkpoint serine-threonine kinase
Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis
Putative serine/threonine protein kinase
Mannosyltransferase, involved in N-linked glycosylation
Alkaline phosphatase specific for p-nitrophenyl phosphate
Putative protein, acetyl coenzyme A transporter
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate
Component of the Rsp5p E3-ubiquitin ligase complex
Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation
One of several homologs of bacterial chaperone DnaJ, located in the ER lumen
Guanyl-nucleotide exchange factor for the small G-protein Sec4p
Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p)
Low-affinity Fe(II) transporter of the plasma membrane
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration