Komagataella phaffii GS115 chromosome 1, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
Genome sequence of the recombinant protein production host Pichia pastoris
Submitted (17-FEB-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (05-MAY-2009) Callewaert N., Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB) / Gent University, Technologiepark 927, Ghent, 9052, BELGIUM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FN392319.\nContact: Nico Callewaert\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent Technologiepark\n927, B-9052 Gent, Belgium\nTel: (32)93313630\nFax: (32)93313609\nEmail: nico.callewaert@dmbr.vib-UGent.be\n----------- sequencing/assembly\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent -----------\nannotation\nUnit for Molecular Glycobiology\nLaboratory for Protein Biochemistry and Biomolecular Engineering\nDepartment of Biochemistry, Physiology and Microbiology, UGent VIB\nDepartment for Molecular Biomedical Research, UGent\n\nLaboratory for Bioinformatics and Evolutionary Genomics VIB\nDepartment of Plant Systems Biology, UGent\nWeb site: http://bioinformatics.psb.ugent.be/\nBioinformatics Online Genome Annotation System (BOGAS):\nhttp://bioinformatics.psb.ugent.be/webtools/bogas/ -----------\n* NOTE: finishing of chromosomes in process\n* Final curation of the annotation in progress.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
Hexose transporter with moderate affinity for glucose
Putative transporter, member of the sugar porter family
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway
Transportin, cytosolic karyopherin beta 2
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation
Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA
Negative regulator of RNA polymerase III
Cytoplasmic inorganic pyrophosphatase (PPase)
Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis
Subunit of heteropentameric Replication factor C (RF-C)
Component of the GARP (Golgi-associated retrograde protein) complex
Nuclear SAM-dependent mono-and asymmetric arginine dimethylating methyltransferase
Defining member of the SET3 histone deacetylase complex
Constituent of the mitochondrial import motor associated with the presequence translocase
Serine/threonine protein kinase involved in activation of meiosis
Essential RNA-binding G protein effector of mating response pathway
Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex
Regulatory subunit of Cdc7p-Dbf4p kinase complex
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex
Class II abasic (AP) endonuclease involved in repair of DNA damage
Component of both the Nup84 nuclear pore sub-complex and of the COPII complex
Uracil permease, localized to the plasma membrane
Phosphotyrosine-specific protein phosphatase
Integral membrane protein required for ER to Golgi transport
Molecular chaperone of the endoplasmic reticulum lumen
Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex
Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p)
Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e
Subunit of the nuclear pore complex (NPC)
Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
Nucleolar protein of unknown function implicated in ribosome biogenesis
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family
S-adenosyl-L-methionine uroporphyrinogen III transmethylase
Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase
Catalytic subunit of DNA polymerase (II) epsilon
Subunit of the origin recognition complex
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p)
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi
Protein with similarity to bovine phospholipase A1
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase
DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator
Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70)
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitoc
Catalytic subunit of the COP9 signalosome (CSN) complex
mitochondrial 54S ribosomal protein YmL19
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p)
Putative RNA-binding protein implicated in ribosome biogenesis
Small rho-like GTPase, essential for establishment and maintenance of cell polarity
Protein required for beta-1,6 glucan biosynthesis
Endoplasmic reticulum packaging chaperone
Mitochondrial ribosomal protein of the large subunit
UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc
mitochondrial 54S ribosomal protein YmL44
Member of the protein disulfide isomerase (PDI) family
Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR)
Type I membrane protein with a J domain is required to preserve the folding capacity of the ER
Protein that forms a complex with the Sit4p protein phosphatase
Alpha-1,2-mannosyltransferase involved in O-and N-linked protein glycosylation
Small subunit of the clathrin-associated adaptor complex AP-1
Protein with a role in cellular adhesion and filamentous growth
Protein kinase primarily involved in telomere length regulation
Protein implicated in polar growth, functionally redundant with Boi1p
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)
Nucleolar protein required for normal metabolism of the rRNA primary transcript
Plasma membrane pyridoxine (vitamin B6) transporter
1-acyl-sn-gylcerol-3-phosphate acyltransferase
Subunit of the Dcp1p-Dcp2p decapping enzyme complex
Hypothetical protein identified by homology
GTPase-activating protein for the polarity-establishment protein Cdc42p
Type II membrane protein required for vesicular transport
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter
Protein with a role in 5'-end processing of mitochondrial RNAs
Peripheral membrane protein required for vesicle formation
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting
One of several homologs of bacterial chaperone DnaJ, located in the ER lumen
Essential protein involved in mtDNA inheritance
Non-essential protein of unknown function
RNA-binding subunit of the mRNA cleavage and polyadenylation factor
Protein involved in proteolytic activation of Rim101p in response to alkaline pH
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase
Putative protein, predicted to be an alpha-isopropylmalate carrier
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from IMP
Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase
Essential, non-ATPase regulatory subunit of the 26S proteasome
Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p)
Permease of basic amino acids in the vacuolar membrane
Mitochondrial peripheral inner membrane protein
Deoxyhypusine synthase, catalyzes formation of deoxyhypusine
Polyamine transport protein specific for spermine
putative catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase
Cis-golgi GTPase-activating protein (GAP)
NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase
Nuclear pore-associated protein, forms a complex with Thp1p
Catalytic subunit of 1,3-beta-D-glucan synthase
Beta-1,3-glucanosyltransferase, required for cell wall assembly
Essential protein involved in rRNA and snoRNA maturation
ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretio
Karyopherin/importin that interacts with the nuclear pore complex
Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate
DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway
Flavin adenine dinucleotide (FAD) synthetase
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex
Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA
Cytoplasmic and mitochondrial histidine tRNA synthetase
Essential protein associated with the U1 snRNP complex
Catalytic subunit of the mitochondrial inner membrane peptidase complex
Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix
Mannosyltransferase of the cis-Golgi apparatus
DNA-binding protein involved in either activation or repression of transcription
DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain
Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin)
Highly-acidic cytoplasmic RWD domain-containing protein of unknown function
Protein involved in the HOG (high osmolarity glycerol) pathway
Proline oxidase, nuclear-encoded mitochondrial protein
Non-essential tRNA:pseudouridine synthase
Putative ATP-dependent RNA helicase, nucleolar protein
Putative cysteine synthase, localized to the mitochondrial outer membrane
Subunit of the core complex of translation initiation factor (eIF3)
Plasma membrane H+-ATPase, pumps protons out of the cell
U3 small nucleolar RNA-associated protein
Inositol hexakisphosphate and inositol heptakisphosphate kinase
Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p)
Component of the TREX complex required for nuclear mRNA export
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation
Component of the mitochondrial Tim54p-Tim22p complex
Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex
Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p
Multistep regulator of cAMP-PKA signaling
ER membrane protein,N-acetylglucosaminyl phosphatidylinositol de-N-acetylase
Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)
Component of the SSU processome, which is required for pre-18S rRNA processing
Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis
Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex
Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F)
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation
Putative protein serine/threonine kinase expressed at the end of meiosis
Transcription factor TFIIB, a general transcription factor
GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
Essential N-acetylglucosamine-phosphate mutase
Putative protein of unknown function, has homology to Staphylococcus aureus nuclease
Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p)
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis
Essential protein of the inner mitochondrial membrane, peripherally localized
Regulatory subunit of type 1 protein phosphatase Glc7p
Non-ATPase regulatory subunit of the 26S proteasome
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate
RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm
Kinesin-related motor protein involved in mitotic spindle positioning
Protein involved in ER-associated protein degradation
Co-chaperone for Hsp40p, anchored in the ER membrane
Essential protein that binds ribosomal protein L11
Protein involved in programmed cell death
Subunit (60 kDa) of TFIID and SAGA complexes
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcript
mitochondrial 37S ribosomal protein RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex)
mitochondrial 37S ribosomal protein MRP2
Histone methyltransferase with a role in transcriptional elongation
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component
MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway
Subunit of the RNA polymerase II mediator complex
NADP(+)-dependent glutamate dehydrogenase
Mitochondrial matrix protein involved in biogenesis of iron-sulfur (Fe/S) cluster of Fe/S proteins
Protein involved in negative regulation of transcription of iron regulon
Karyopherin beta, responsible for the import of the Toa1p-Toa2p complex into the nucleus
Subunit of heterotrimeric Replication Protein A (RPA)
Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p)
Lipid-binding protein, localized to the bud via specific mRNA transport
Putative sensor/transporter protein involved in cell wall biogenesis
General transcriptional co-repressor, acts together with Tup1p
Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex
Protein required for accurate chromosome segregation
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease comple
Homolog of the prokaryotic ribosomal protein L36
Cytoplasmic protein with a role in regulation of Ty1 transposition
Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein
Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor
Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p)
Serine/threonine protein phosphatase Z, isoform of Ppz2p
Small subunit of the heterodimeric cap binding complex that also contains Sto1p
Nuclear thiol peroxidase, functions as an alkyl-hydroperoxide reductase during post-diauxic growth
Putative transmembrane protein involved in export of ammonia, a starvation signal
Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen
N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis
Putative protein of fumarylacetoacetate hydrolase family protein
RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane
Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway
Protein required for the ubiquinone (Coenzyme Q) biosynthesis
N-myristoylated calcium-binding protein that may have a role in intracellular signaling
Negative regulator of the glucose-sensing signal transduction pathway
ATP-dependent Lon protease involved in degradation of misfolded proteins in mitochondria
Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport
Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis
Putative GTPase involved in 60S ribosomal subunit biogenesis
Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex
Non-catalytic subunit of N-terminal acetyltransferase of the NatC type
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase
mitochondrial 54S ribosomal protein RML2
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase)
Component of the spliceosome complex involved in pre-mRNA splicing
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA
Cytosolic aspartate aminotransferase; involved in nitrogen metabolism
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway
Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4
Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis
Putative vacuolar protein sorting-associated protein vps13
Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria
Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein
Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport
Low affinity methionine permease, similar to Mup1p
Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family
Nuclear pore-associated protein, forms a complex with Sac3p
Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore
Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate
Protein binding phosphatidylinositol 3-phosphate
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p
Protein whose overexpression affects chromosome stability, potential Cdc28p substrate
Protein required, with Elongator complex, Kti11p & Kti12p, for modification of wobble nucleosides in
Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene
DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p
Structural maintenance of chromosomes (SMC) protein
Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery
Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme
Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p)
Essential protein that associates with the contractile actomyosin ring
Alpha-tubulin folding protein, similar to mammalian cofactor B
Uracil phosphoribosyltransferase, synthesizes UMP from uracil
Actin-related protein of the dynactin complex
Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum
Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs
Evolutionarily conserved non-essential protein present in early Golgi cisternae
Protein tyrosine phosphatase involved in cell cycle control
Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection
Endoplasmic reticulum transmembrane protein
Protein with a possible role in tRNA export
Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP
One of two large regulatory subunits of ribonucleotide-diphosphate reductase
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose
Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan
Alpha subunit of COPI vesicle coatomer complex
JmjC domain family histone demethylase specific for H3-K36
Mitochondrial ribosomal protein of the small subunit
Essential, non-ATPase regulatory subunit of the 26S proteasome lid
Plasma membrane glucose sensor that regulates glucose transport
Prenyltransferase, required for cell viability
Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1)
Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase
Subunit 7 of the ubiquinol cytochrome-c reductase complex
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase)
Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33)
Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria
90S preribosome/SSU processome component KRR1
Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating
Member of the alpha/beta knot fold methyltransferase superfamily
Protein required for partitioning of the 2-micron plasmid
Protein kinase involved in bud growth and assembly of the septin ring
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus
Protein involved in mating response, invasive/filamentous growth, and osmotolerance
Essential protein involved in rRNA processing and ribosome biogenesis
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity
Ceramide synthase component, involved in synthesis of ceramide
2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism
Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p
One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC)
Protein with a positive role in the multivesicular body sorting pathway
Non-essential tetra-spanning membrane protein found mostly in the late Golgi
Conserved NAD+ dependent histone deacetylase of the Sirtuin family
mitochondrial 37S ribosomal protein YmS-T
Putative transmembrane protein involved in export of ammonia
GPI-anchored aspartyl protease (yapsin) involved in protein processing
bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response
Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
mitochondrial 37S ribosomal protein MRPS8
DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis
Mitochondrial asparaginyl-tRNA synthetase
Hypothetical protein with low sequence identity to Pdc1p
Nucleotide pyrophosphatase/phosphodiesterase family member
Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis
Plasma membrane ATP binding cassette (ABC) transporter
Mitochondrial protein, putative inner membrane transporter
Putative integral membrane protein of unknown function
Subunit of the heterohexameric cochaperone prefoldin complex
Vacuolar ATPase assembly integral membrane protein VMA21
C-14 sterol reductase, acts in ergosterol biosynthesis
Nuclear protein involved in asymmetric localization of ASH1 mRNA
Acetate transporter required for normal sporulation
Acyl-coenzymeA:ethanol O-acyltransferase
Phosphatidylserine synthase, functions in phospholipid biosynthesis
Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV)
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
Phosphoribosylpyrophosphate amidotransferase
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity
Zinc finger protein involved in control of meiosis
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP
Ubiquitin-conjugating enzyme involved in ER-associated protein degradation
Component of the small-subunit (SSU) processome
Cytoplasmic protein required for sporulation
Non-essential protein of unknown function, likely exists as tetrame
Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis
Saccharopine dehydrogenase (NAD+, L-lysine-forming)
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus
Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C
Protein involved in bud-site selection and required for axial budding pattern
Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm
Phosphatidylinositol-4-phosphate 5-kinase
Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex
Vacuolar endopolyphosphatase with a role in phosphate metabolism
Phosphatidylserine decarboxylase of the mitochondrial inner membrane
Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III)
cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex
Frataxin, regulates mitochondrial iron accumulation
Cofilin, promotes actin filament depolarization in a pH-dependent manner
tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNA
Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis
High affinity iron permease involved in the transport of iron across the plasma membrane
Multicopper oxidase, integral membrane protein with similarity to Fet3p
Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase)
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and subtelomeric DNA
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis
putative rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme
Putative mannosyltransferase involved in protein glycosylation
RNA-dependent ATPase RNA helicase (DEIH box)
Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1
G1 cyclin involved in cell cycle progression
RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p
Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p
Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1)
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity
Co-chaperone that binds to Hsp82p and activates its ATPase activity
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme
Integral membrane protein required for efficient mating
Multidrug transporter of the major facilitator superfamily
Fatty acid transporter and very long-chain fatty acyl-CoA synthetase
Protein phosphatase required for mitotic exit
Putative cytoplasmic protein of unknown function
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase
Chromatin modification-related protein EAF6
Phosphatidylethanolamine methyltransferase (PEMT)
Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration
Essential nucleolar protein required for 40S ribosome biogenesis
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
Non-essential conserved protein of unknown function, plays a role in mRNA decapping
Phosphorylated vacuolar membrane protein that interacts with Atg13p
putative mitochondrial seryl-tRNA synthetase
Involved in vesicular transport, mediates transport between an endosomal compartment and the golgi
Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor)
Exonuclease component of the nuclear exosome
Protein involved in iron metabolism in mitochondria
pterin-4-alpha-carbinolamine dehydratase
Mu1-like medium subunit of the clathrin-associated protein complex (AP-1)
Glutamine-rich cytoplasmic protein of unknown function
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase
Essential protein involved in the TOR signaling pathway
Transcription initiation factor IIA small subunit
Essential conserved subunit of CPF (cleavage and polyadenylation factor)
Mitochondrial NADH kinase, phosphorylates NADH
Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion
Essential protein required for determination of budding pattern
Protein with similarity to mammalian monocarboxylate permease
AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p
Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex
Beta subunit of the translation initiation factor eIF2
Membrane-associated RING finger protein 5
Cytoplasmic ankyrin-repeat containing protein of unknown function
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN)
Type II phosphatidylinositol 4-kinase that binds Las17p
eukaryotic translation initiation factor 3 subunit
3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis
Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcrip
Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p)
Protein that interacts with exonuclease Rat1p and Rai1p
GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5
Class E protein of the vacuolar protein-sorting (Vps) pathway
mitochondrial 54S ribosomal protein MRPL51
Mitochondrial inner membrane localized ATP-dependent DNA helicase
Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway
Meiosis-specific protein that initiates meiotic recombination
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis
Subunit (145 kDa) of TFIID and SAGA complexes
TATA-binding protein, general transcription factor
18kDa catalytic subunit of the Signal Peptidase Complex
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification
ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p
DDK (Dbf4-dependent kinase) catalytic subunit
Polyamine transporter that recognizes spermine, putrescine, and spermidine
Phosphatidylinositol 3,5-bisphosphate-binding protein
Pantothenate synthase, also known as pantoate-beta-alanine ligase
WD40 repeat-containing subunit of the Set3C histone deacetylase complex
Mitochondrial protein involved in protein import into the mitochondrial matrix
Component of the holoenzyme form of RNA polymerase transcription factor TFIIH
Ubiquitin-like protein of the SUMO family
Oleic acid-inducible, peroxisomal matrix localized lipase
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase
Mitochondrial ATP-dependent RNA helicase of the DEAD-box family
tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA
Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p)
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein
Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme
RNA binding protein that negatively regulates growth rate
Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles
Plasma membrane protein of unknown function
Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis
ATP phosphoribosyltransferase (hexameric enzyme) catalyzes the first step in histidine biosynthesis
Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p
Mitochondrial protein involved in maintenance of the mitochondrial genome
Putative mannosidase, GPI-anchored membrane protein
Threonine deaminase, catalyzes the first step in isoleucine biosynthesis
Epsin-like protein involved in endocytosis and actin patch assembly
Component of the core form of RNA polymerase transcription factor TFIIH
Divalent metal ion transporter involved in manganese homeostasis
Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
Acetyl-CoA carboxylase, biotin containing enzyme
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation
Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP)
Putative zinc-cluster protein of unknown function
Putative membrane protein of unknown function
Alpha' catalytic subunit of casein kinase 2
Golgi matrix protein involved in the structural organization of the cis-Golgi
Mitogen-activated kinase kinase involved in protein kinase C signaling pathway
WD-repeat protein involved in ribosome biogenesis
Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p
MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway
Putative serine/threonine protein phosphatase, required for glycogen accumulation
Telobox-containing general regulatory factor
Poly(A) binding protein, part of the 3'-end RNA-processing complex
Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNA
Inositol polyphosphate multikinase (IPMK)
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane
Protein that binds Sin3p in a two-hybrid assay
Mitochondrially localized type 2C protein phosphatase
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme
Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme
Golgi membrane protein with similarity to mammalian CASP
Subunit of the SWI/SNF chromatin remodeling complex
Subunit 8 of ubiquinol cytochrome-c reductase complex
Member of silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases
Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles
Transcription initiation factor TFIID subunit 3
mitochondrial 37S ribosomal protein MRPS16
High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi
Essential 100kDa subunit of the exocyst complex
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector
Essential nucleolar protein of unknown function
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p)
Putative ATP-dependent RNA helicase of the DEAD-box protein family
cAMP-dependent protein kinase catalytic subunit
putative mitochondrial 54S ribosomal protein MNP1
Cyclin-dependent kinase-activating kinase required for passage through the cell cycle
Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SAL
Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol
Protein kinase required for signal transduction during entry into meiosis
Subunit of an adoMet-dependent tRNA methyltransferase (MTase) complex (Trm11p-Trm112p)
Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest
ER membrane localized phosphoryltransferase that adds phosphoethanolamine
Ser/Thr protein kinase involved in salt tolerance
Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline
Member of a stationary phase-induced gene family
Ammonium permease involved in regulation of pseudohyphal growth
Subunit of the heterohexameric Gim/prefoldin protein complex
Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth
Helix-loop-helix protein that binds the motif CACRTG
Putative positive regulator of mannosylphosphate transferase (Mnn6p)
Essential protein, component of a complex containing Cef1p
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p
Mitochondrial pyrimidine nucleotide transporter
Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization
Protein involved in biosynthesis of the coenzyme lipoic acid
Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase)
Plasma membrane multidrug transporter of the major facilitator superfamily
Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs)
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation
Integral membrane protein of unknown function
B-type cyclin involved in cell cycle progression
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase
Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol
Catalytic component of UDP-GlcNAc transferase
N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase
Essential 88kDa subunit of the exocyst complex
tRNA methyltransferase required for the synthesis of wybutosine
Uridine kinase (Uridine monophosphokinase)
Nucleolar protein required for maturation of 18S rRNA
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase
mitochondrial 37S ribosomal protein RSM27
Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI)
Meiosis-specific APC/C activator protein AMA1
Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER
Regulatory, non-ATPase subunit of the 26S proteasome
Evolutionarily conserved copper-binding protein of the mitochondrial inner membrane
mitochondrial 54S ribosomal protein YmL31
Nucleolar protein, required for pre-25S rRNA processing
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
One of three possible beta-subunits of the Snf1 kinase complex
Protein involved in exosome mediated 3' to 5' mRNA degradation
Essential nuclear protein possibly involved in bud formation and morphogenesis
Endosomal subunit of membrane-associated retromer complex required for retrograde transport
Protein required for processing of 20S pre-rRNA in the cytoplasm
Protein involved in regulated synthesis of PtdIns(3,5)P(2)
Protein involved in nitrosoguanidine (MNNG) resistance
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P
Co-chaperone that stimulates the ATPase activity of Ssa1p
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway
Conserved cysteine protease required for autophagy
Small nuclear ribonucleoprotein-associated protein
GTPase of the Ypt/Rab family, very similar to Ypt31p
Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p
Structural maintenance of chromosomes protein
mitochondrial 37S ribosomal protein MRPS35
Essential nucleolar protein involved in pre-18S rRNA processing
Clathrin heavy chain, subunit of the major coat protein
Formylglycinamidine-ribonucleotide (FGAM)-synthetase
Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway
mitochondrial 54S ribosomal protein YmL47
Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer
Mitochondrial protein, forms a heterodimer complex with Mto1p
Low-affinity cyclic AMP phosphodiesterase
High-affinity glucose transporter of the major facilitator superfamily
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
Ubiquitin-specific protease that interacts with Bre5p
Nuclear polyadenylated RNA-binding protein
Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex
General negative regulator of transcription subunit 4
Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p
Subunit of the RNA polymerase II-associated Paf1 complex
Cytosolic protein required for sporulation
Essential nuclear envelope integral membrane protein required for nuclear transport
Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization
N(6)-adenine-specific DNA methyltransferase
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
Vacuolar aminopeptidase Y, processed to mature form by Prb1p
WD repeat protein required for ubiquitin-mediated protein degradation
C-1-tetrahydrofolate synthase, mitochondrial
5' to 3' exonuclease, 5' flap endonuclease
Protein that forms heterodimers with Msh3p and Msh6p
Mitochondrial protein required for the stability of Oli1p mRNA and for the Oli1p ring formation
Dynamin-like GTPase required for vacuolar sorting
Mitochondrial respiratory chain complexes assembly protein RCA1
Chromatin structure-remodeling complex protein RSC7
Subunit of SAGA histone acetyltransferase complex
mitochondrial 54S ribosomal protein YmL28
H subunit of the mitochondrial glycine decarboxylase complex
Vacuolar protein sorting-associated protein 70
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Phytanoyl-CoA dioxygenase domain-containing protein
54S ribosomal protein L24, mitochondrial
Vacuolar protein sorting-associated protein 27
Translational elongation factor EF-1 alpha
Glycine dehydrogenase [decarboxylating], mitochondrial
Phosphatidylglycerol/phosphatidylinositol transfer protein