Candida dubliniensis CD36 chromosome 7, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992694.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
incomplete sequence, apparent frameshift, probable pseudogene; Similar to C. albicans YRF1, (HPR5)
serine/threonine-protein phosphatase 1 regulatory subunit, putative
dicarboxylic amino acid permease, putative
Similar to S. cerevisiae DIP5; spliced gene
Similar to S. cerevisiae GUS1; glutamyl-tRNA synthetase, cytoplasmic, putative
Similar to S. cerevisiae RMD8; In S. cerevisiae: required for meiotic nuclear division
phosphoribulokinase/uridine kinase family protein, putative
DNA-directed RNA polymerase I subunit, putative
Similar to S. cerevisiae THG1; tRNA-histidine guanylyltransferase, putative
Similar to S. cerevisiae GLN4; glutaminyl-tRNA synthetase, putative
subunit of the DNA replication complex GINS, putative
Similar to S. cerevisiae CTR9; RNA polymerase-associated protein Ctr9 homologue, putative
Similar to S. cerevisiae HAA1; possibly subject to regulation by copper levels
S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, putative
inorganic phosphate transporter, putative
identified as a regulator of filamentous growth: Uhl et al. (2003). EMBO J 22(11): 2668-2678; Similar to S. cerevisiae PHO84
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase, putative
Similar to S. cerevisiae PGS1; phosphatidylglycerophosphate synthase, putative
SAGA histone acetyltransferase complex subunit, putative
Similar to S. cerevisiae SGF29; SAGA-associated factor, putative
Similar to S. cerevisiae GBP2; single-strand telomeric DNA-binding protein, putative
ferric reductase transmembrane component, putative
Similar to S. cerevisiae FRE7; ferric-chelate reductase, putative
possible assembly problems, either here or in C. albicans; possibly yeast-specific
amphiphysin-like lipid raft protein, putative
In S. cerevisiae: subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress; In S. pombe: involved in cytokinesis and septation where it has a role in the localization of F-actin; Similar to S. cerevisiae RVS161; Similar to S. pombe HOB3
Similar to S. cerevisiae RAD3; DNA repair helicase Rad3 homologue, putative; transcription initiation factor TFIIH subunit, putative
mitochondrial adenylate kinase, putative
RNA polymerase-associated protein, putative
Similar to S. cerevisiae LEO1; In S. cerevisiae: component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation
GTPase-activating protein for RHO1, putative
contains CFAM domain (Pfam:PF05730) -fungal-specific cysteine rich domain found in some proteins with proposed roles in fungal pathogenesis; glycosyl-phosphatidylinositol protein
ferric reductase transmembrane component precursor, putative
manganese-containing superoxide dismutase, putative
Similar to S. cerevisiae FIS1; mitochondrial outer membrane protein membrane fission effector, putative
tRNA-specific adenosine deaminase, putative
Similar to S. cerevisiae TAD1; in S. cerevisiae: deaminates adenosine-37 to inosine in tRNA-Ala
putative ankyrin repeat-containing protein ygl242c
pentose-5-phosphate 3 epimerase, putative
Similar to S. cerevisiae RPE1; ribulose-phosphate 3-epimerase, putative
N-acetylated-alpha-linked acidic dipeptidase I, putative
Similar to Sus scrofa FOLH1; Similar to S. cerevisiae VPS70; folate hydrolase, putative; folylpoly-gamma-glutamate carboxypeptidase, putative; membrane glutamate carboxypeptidase, putative; prostate-specific membrane antigen homolog, putative; pteroylpoly-gamma-glutamate carboxypeptidase, putative; vacuolar protein sorting-associated protein, putative
The CGD description of this gene as a FAR1 orthologue (cyclin-dependent protein kinase inhibitor) is not supported by Fasta/BlastP hits.
good for full dbp5 activity protein 2 homologue, putative
Similar to S. cerevisiae GFD2; transcriptional repressor, putative
telomere length regulation protein, putative
Similar to S. cerevisiae TEL2; In S. cerevisiae: essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
vacuolar amino acid transporter, putative
cytoplasmic RNA-binding protein, putative
glucose transporter of the major facilitator superfamily, putative
high-affinity glucose transporter, putative
Similar to S. cerevisiae STL1; sugar transporter, putative
conserved hypothetical mitochondrial protein
In S. cerevisiae: required for Ca2+ and Mn2+ transport into Golgi; high affinity Ca2+/Mn2+ P-type ATPase, putative
protein required for respiratory growth, putative
Similar to S. cerevisiae KAP114; karyopherin subunit, putative; nuclear import protein, putative
sister-chromatid cohesion and telomere length maintenance complex subunit, putative
S-adenosylmethionine transporter of the mitochondrial inner membrane, putative
Similar to S. cerevisiae PET8; spliced gene; mitochondrial carrier protein, putative
cysteine desulfurase, mitochondrial precursor, putative
tRNA splicing protein Spl1 homologue, putative
3-isopropylmalate dehydrogenase, putative
private: C-terminal third of ScBUD3 appears to be missing; Similar to S. cerevisiae BUD3
retrotransposon:solo LTR, psi J, partial
In S. cerevisiae: constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
subunit of the RNA polymerase II-associated Paf1 complex, putative
Similar to S. cerevisiae RTF1; In S. cerevisiae: involved in telomere maintenance
transcriptional activator involved in regulation of sulfur metabolism, putative
serine/threonine-protein kinase, putative
Similar to S. cerevisiae ACB1; has been marked up in CGD, but is not yet in UniProt (as of May 2007); spliced gene
core RPS block consists of six RPS units of varying lengths; RPS_1 is 2106bp long, RPS_2 is 1934bp long, and RPS_3, 4 and 5 are 2107bp long, RPS_6 is partial, at 1530 bp long; orientation = reversed
Similar to C. dubliniensis UniProt:Q8TGW0; located in MRS RB2 region; very similar to Q8TGW0 in C. dubliniensis, but lacks middle third of the sequence; fragmented, but with no splice consensus sequences; in-frame stop codon in N-terminus
RPS (RePeat Sequence) domain; the six RPS units are of varying lengths; RPS_1 is 2106bp long, RPS_2 is 1934bp long, and RPS_3, 4 and 5 are 2107bp long; RPS_6 is partial (1530 bp)
Similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS_1
cleavage factor II (CF II) component, putative
Similar to S. cerevisiae PTA1; In S. cerevisiae: subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII; polyadenylation factor I (PF I), putative; pre-tRNA-processing protein, putative
private: fusion of albicans initial alleles: orf19.7038 + orf19.7039; In S. cerevisiae: required for sorting proteins to the vacuole; spliced gene
uncharacterized protein yjr067c homologue, putative
growth/cell cycle/stress response regulation protein, putative
private: In S. cerevisiae: protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; Similar to S. cerevisiae WHI2
dual specificity protein phosphatase, putative
covalently linked cell wall protein, putative
Similar to S. cerevisiae GUD1; guanine deaminase, putative
apparent fusion of albicans alleles orf19.7027 + orf19.7028
most of internal region and most of right LTR missing. No PBS following left LTR
retrotransposon:solo LTR, huia E, truncated
cell-type-and pheromone-response-specific transcriptional modulator, putative
Similar to S. cerevisiae MCM1; pheromone receptor transcription factor, putative
component of the ISW1B complex, putative
Similar to C. albicans IOC4; subunit of chromatin remodelling complex, putative
In S. cerevisiae: cleaves alpha factor precursor and killer toxin; Similar to S. cerevisiae KEX1
mitochondrial 54S ribosomal protein YmL6
Similar to S. cerevisiae RPS18; spliced gene
homeodomain-containing transcriptional repressor, putative
In S. cerevisiae: binds MCM1 and ECBs (early cell boxes) in the promoters of genes expressed in M/G1; Similar to S. cerevisiae YOX1
vaculoar endopolyphosphatase precursor, putative
In S. cerevisiae: role in phosphate metabolism; Similar to S. cerevisiae PPN1
mitochondrial 37S ribosomal protein MRPS16
pre-ribosomal RNA component binding protein, putative
Similar to S. cerevisiae RRP12; ribosome export protein, putative
assembly of substrate-specific ubiquitin ligase complexes modulator, putative
In S. cerevisiae: HOG- and stress- induced; Similar to S. cerevisiae GRE2; NADPH-dependent methylglyoxal reductase, putative
LigB subunit of aromatic ring-opening dioxygenase, putative
Similar to Aspergillus fumigatis AFUA_6G02950
NADH-ubiquinone oxidoreductase subunit, putative
Similar to Neurospora crassa NUO10.5; Pichia stipitis NUO10
Similar to Aspergillus fumigatus qutH; quinate utilisation oxidoreductase, putative
mitochondrial inheritance complex (MDM12/MDM10/MMM1) subunit, putative
In S. cerevisiae: required for transmission of mitochondria to daughter cells; Similar to S. cerevisiae MDM12; mitochondrial outer membrane protein, putative
non-essential hydrolase involved in mRNA decapping, putative
In S. cerevisiae: may function in a feedback mechanism to regulate deadenylation; Similar to S. cerevisiae DCS1
DEAD-box family ATP-dependent RNA helicase, ribosomal biogenesis, putative
eIF-2b GDP-GTP exchange factor, putative
In S. cerevisiae: activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression; Similar to S. cerevisiae GCN3; guanine nucleotide exchange factor subunit, putative; translation initiation factor eIF-2b alpha subunit, putative
WD repeat protein (G-beta like protein) involved in translation regulation, putative
Similar to S. cerevisiae ASC1; spliced gene; orthologue of mammalian RACK1, putative; part of 40S ribosomal subunit, putative
Similar to S. cerevisiae FOL3; folylpoly-gamma-glutamate synthetase, putative; folylpolyglutamate synthase, putative; tetrahydrofolate synthase, putative; tetrahydrofolylpolyglutamate synthase, putative
essential subunit of the RNA polymerase II mediator complex, putative
In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; Similar to S. cerevisiae MED11
DNA replication initiation GINS complex subunit, putative
In S. cerevisiae: subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Similar to S. cerevisiae PSF1
In S. cerevisiae: primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; also exhibits choline kinase activity; Similar to S. cerevisiae EKL1; ethanolamine kinase, putative
In S. cerevisiae: phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; Similar to S. cerevisiae GCN2
manganese-dependent, structurally specific endonuclease/3'-5' exonuclease, putative
In S. cerevisiae: the RMX complex functions in repair of DNA double-strand breaks and in telomere stability; Similar to S. cerevisiae MRE11; subunit of the RMX [Rad50-Mre11-Xrs2] complex, putative
molecular chaperone, assembly of mitochondrial F1F0 ATP synthase, putative
heat shock protein, mitochondrial protein import, putative
Similar to S. cerevisiae TIM15; mitochondrial translocase complex subunit, putative
Nap1 Binding Protein homologue, putative
In S. cerevisiae: protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p; Similar to S. cerevisiae NBP2
Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, putative
Similar to S. cerevisiae GIR2; protein Gir2 homologue, putative
subunit of the core complex of translation initiation factor 3 (eIF3), putative
In S. cerevisiae: part of a subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; Similar to S. cerevisiae PRT1; translation initiation factor, putative
Similar to S. cerevisiae PRE10; spliced gene; macropain subunit, putative; multicatalytic endopeptidase complex subunit, putative; proteinase YSCE subunit, putative
Similar to S. cerevisiae PFA4; protein fatty acyltransferase, putative
high-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter, putative
Similar to S. cerevisiae PHO84; inorganic phosphate transporter, putative
putative fluconazole resistance protein; In S. cerevisiae: polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; Similar to S. cerevisiae TPO1; polyamine transporter, putative
Similar to S. cerevisiae ERG5; In S. cerevisiae: a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs; cytochrome P450 61, putative
cellular morphogenesis/bud emergence/cytoskeleton organization Rho GTPase activating protein (RhoGAP), putative
Similar to S. cerevisiae SMC6; growth, DNA repair, interchromosomal and sister chromatid recombination protein, putative; structural maintenance of chromosomes (SMC) protein, putative
cytochrome oxidase biogenesis protein, putative
Similar to S. cerevisiae OXA1; inner membrane protein, mitochondrial precursor, putative; mitochondrial inner membrane translocase, putative; oxidase assembly protein, putative
mitochondrial membrane protein, putative
dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, putative
Similar to S. cerevisiae PDA2; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor, putative
tau subunit of RNA polymerase III transcription initiation factor complex (TFIIIC), putative
Similar to S. cerevisiae TFC7; spliced gene
GTPase activating transport protein, putative
Similar to S. cerevisiae AMD2; amidase, putative
medator of assembly of small mitochondrial TIM (Translocase of the Inner Membrane) complexes, putative
Similar to S. cerevisiae HOT13; mitochondrial intermembrane space protein, putative
In S. cerevisiae: involved in disulfide bond formation within the ER; Similar to S. cerevisiae ERV2
In S. cerevisiae: involved in activation of the mating signalling pathway; Similar to S. cerevisiae STE18; spliced gene
Golgi SNAP receptor complex member, putative
Similar to S. cerevisiae GOS1; Golgi transport v-SNARE protein, putative
iron sulfur cluster assembly protein, mitochondrial precursor, putative
Similar to S. cerevisiae ISU1; iron sulfur cluster scaffold protein mitochondrial precursor, putative
Glc7 interacting protein homologue, putative
Similar to S. cerevisiae GIP3; protein phosphatase regulator, putative
In S. cerevisiae: requied for 60S ribosomal subunit assembly; Similar to S. cerevisiae RPL5
6-phosphofructokinase beta subunit, putative
Similar to S. cerevisiae PFK2; phosphofructokinase 2, putative; phosphohexokinase, putative
chromatin remodeling complexes component, putative
Similar to S. cerevisiae RVB2; trancription modulator, RuvB-like protein family member, putative
Similar to S. cerevisiae VMA11; v-ATPase c' subunit, putative; v-ATPase proteolipid subunit, putative; vacuolar ATP synthase subunit c', putative; vacuolar proton pump c' subunit, putative
Ras GTPase-activating-like protein, IQGAP family member, putative
Similar to S. cerevisiae IQG1; bud site selection/morphogenesis modulator, putative; ring assembly protein, putative
Similar to S. cerevisiae CRN1; spliced gene; cortical actin cytoskeletal component, putative
Similar to S. cerevisiae MSK1; mitochondrial lysyl-tRNA synthetase, putative
mitochondrial flavine adenine dinucleotide (FAD) carrier protein, putative
NADH-ubiquinone oxidoreductase subunit, mitochondrial precursor, putative
Similar to Neurospora crassa NUO49; respiratory chain complex I subunit, putative
E3 ubiquitin ligase complex SCF subunit, putative
Similar to S. cerevisiae CDC34; cell division control protein, putative; ubiquitin carrier protein, putative; ubiquitin-conjugating enzyme E2, putative; ubiquitin-protein ligase, putative
pheromone-regulated membrane protein, putative
rhomboid family [serine] protease, putative
peripheral membrane protein of peroxisomes, putative
In S. cerevisiae: involved in peroxisomal inheritance; Similar to S. cerevisiae INP1
core element of the mitochondrial protein conducting pore, putative
Similar to S. cerevisiae TOM40; mitochondrial import receptor subunit, putative; translocase of outer membrane (TOM) subunit, putative
retrotransposon:solo LTR, episemon D, truncated
retrotransposon:solo LTR, epsilon M, truncated
major facilitator superfamily transporter, putative
Similar to S. cerevisiae HFD1; mitochondrial outer membrane/lipid particles fatty aldehyde dehydrogenase, putative
Similar to S. cerevisiae RAD14; Nucleotide Excision repair Factor 1 (NEF1) damaged-DNA-binding subunit, putative; XPA protein homolog, putative
ATP-dependent molecular chaperone, HSP90 family, putative
Similar to S. cerevisiae HSC82; heat shock protein 82 homolog, putative
homeobox-containing transcription factor, putative
In S. cerevisiae: the exocyst complex mediates polarized targeting of secretory vesicles to active sites of exocytosis; Similar to S. cerevisiae EXO70
In S. cerevisiae: hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage; Similar to S. cerevisiae GRX1; glutathione-dependent disulphide oxidoreductase, putative
In S. cerevisiae: cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity; stress-induced; Similar to S. cerevisiae GRX2; glutathione reductase, putative; thioltransferase, putative
nitrogen-regulated amino acid permease pathway effector, putative
In S. cerevisiae: required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; Similar to S. cerevisiae LST7; post-Golgi secretory pathway protein, putative
Similar to S. cerevisiae MAP2; spliced gene
histone deacetylase complex subunit, putative
large-subunit ribosomal protein, mitochondrial precursor, putative
retinal short-chain dehydrogenase/reductase 1, putative
Similar to Bos taurus SDR1; Bos taurus DHRS3; short-chain dehydrogenase/reductase 3, putative
Similar to S. cerevisiae YJU3; serine hydrolase, putative
amino-acid acetyltransferase (n-acetylglutamate synthase) (ags), putative
Similar to S. cerevisiae ECM40; arginine biosynthesis bifunctional protein, mitochondrial precursor, putative; extracellular matrix protein, putative; glutamate n-acetyltransferase (ornithine acetyltransferase) (ornithine transacetylase) (oatase), putative; mitochondrial ornithine acetyltransferase/acetylglutamate synthase, putative
DNA-directed RNA polymerase, mitochondrial precursor, putative
In S. cerevisiae: single subunit enzyme, similar to those of T3 and T7 bacteriophages; Similar to S. cerevisiae RPO41
uncharacterized protein IWR1 (Interacts With RNA polymerase II) homologue, putative
transport protein particle (TRAPP) (ER to Golgi trafficking) subunit, putative
Similar to S. cerevisiae WHI4; cell cycle modulator, dose-dependent inhibitor of start, putative
serine/threonine protein kinase, putative
endocytosis/sphingolipid biosynthesis/sporulation effector, putative
Similar to S. cerevisiae FMP45; mitochondrial/eiosome integral membrane protein, putative
hypothetical LDG family protein, Candida conserved
GPI-anchored aspartic protease, putative
Similar to S. cerevisiae YPS7; aspartic protease, putative
[nucleotide sugar/triose phosphate] transporter, putative
Similar to S. cerevisiae YMD8; transporter, putative
vesicular transport Sm-like protein, putative
Similar to S. cerevisiae SEC1; In S. cerevisiae: involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane
multidrug/metal (cadmium, mercury, and arsenite) resistance protein, putative
Similar to S. cerevisiae YCF1; vacuolar glutathione S-conjugate transporter, ATP-binding cassette family member, putative; vacuolar metal resistance ABC transporter, putative
tRNA (guanine-n(7)-)-methyltransferase complex subunit, putative
conserved protein involved in exocytic transport from the Golgi, putative
Similar to S. cerevisiae AVL9; protein AVL9 homologue, putative
Similar to S. cerevisiae CPR1; cyclosporin A-binding protein, putative; cytoplasmic peptidyl-prolyl cis-trans isomerase, putative; rotamase, putative
Similar to S. cerevisiae AHP1; peroxiredoxin type-2, putative; thiol-specific peroxiredoxin, putative
conserved hypothetical ATP binding protein, putative
Similar to S. cerevisiae NPA3; conserved hypothetical cytoplasmic ATPase, putative
cytochrome C oxidase assembly protein, mitochondrial precursor, putative
Similar to S. cerevisiae COX20; mitochondrial inner membrane protein, putative
AAA-family ATPase, peroxisome biogenesis protein, putative
Similar to S. cerevisiae PEX1; peroxin 1, putative
diacylglycerol pyrophosphate (DGPP) phosphatase, putative
Similar to S. cerevisiae DPP1; phosphatidate phosphatase, putative
U6 snRNA-associated Sm-like protein, putative
Similar to S. cerevisiae LSM4; spliced gene
Similar to S. cerevisiae FPR1; peptidyl-prolyl cis-trans isomerase, putative; rapamycin-binding protein, putative
component of the mitochondrial Translocase of the Outer Membrane (TOM), putative
homolog of human tumor suppressor gene PTEN/MMAC1/TEP1, putative
Similar to S. cerevisiae TEP1; SpPTN1; CaJ7.0306; In S. cerevisiae: linked to the phosphatidylinositol signaling pathway and plays a role in the developmental process of sporulation; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative
G1 cell-cycle-arrest modulator protein, putative
Similar to S. cerevisiae FAR11; mating-factor arrest protein, putative
mitochondrial import receptor subunit, putative
Similar to S. cerevisiae TOM22; subunit of the TOM (translocase of outer membrane) complex, putative; translocase of mitochondrial outer membrane, subunit, putative
diacylglycerol cholinephosphotransferase, putative
Similar to S. cerevisiae EPT1; diacylglycerol ethanolaminephosphotransferase, putative; sn-1,2-diacylglycerol ethanolamine-and cholinephosphotranferase, putative
core RPS block consists of eighteen complete RPS units of 2106bp each, plus one partial RPS unit of 1535bp; orientation = sense
Similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS_2
RPS (RePeat Sequence) domain; last RPS unit is partial
located in RB2 region of MRS; similar to Candida albicans FGR6-1; transposon mutation affects filamentous growth; identified as a regulator of filamentous growth in C. albicans: Uhl et al. (2003). EMBO J 22(11): 2668-2678
Similar to S. cerevisiae CHS2; chitin-UDP acetyl-glucosaminyl transferase, putative
nucleocytoplasmic trafficking regulator of macromolecules, putative
Similar to S. cerevisiae SRM1; nucleotide exchange factor, putative; pheromone response pathway component, putative; regulator of chromosome condensation, putative
DNA polymerase delta catalytic subunit, putative
Tca4-like retrotransposon reverse transcriptase, putative
Similar to S. cerevisiae SKN7; nuclear response regulator and transcription factor, putative
Similar to S. cerevisiae PRX1; thioredoxin peroxidase, putative
non-LTR, zorro-like retrotransposon family polyprotein fragment, putative
ORF containing Zorro-like EN. Probably a host gene
fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth; may be a target of azole antifungal drugs; Similar to S. cerevisiae ERG5; cytochrome p450 subunit, putative
Similar to C. albicans LIP5; member of differentially expressed lipase gene family with possible roles in nutrition and acidic microenvironment; LIP5 and LIP8 expressed at all stages of mucosal and systemic infection; affects filamentous growth
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase, putative
required for virulence in mouse systemic infection and for adhesion to epithelial cells; has a role in hyphal growth and drug sensitivity; Similar to S. cerevisiae PMT1; protein O-mannosyltransferase, putative
ER/nuclear-envelope ubiquitin-protein ligase, putative
TATA binding protein-Associated Factor, putative
Similar to S. cerevisiae TAF13; TBP-associated factor 13, putative; transcription initiation factor TFIID subunit, putative
Similar to C. albicans LIP9; C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue (Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Hube B, Stehr F, Bossenz M, Mazur A, Kretschmar M, Schafer W; Arch Microbiol 2000;174:362-374.)
retrotransposon:solo LTR, epsilon N, partial
Similar to S. cerevisiae ENA2; partial sequence; gene believed to be spliced, but upstream exon(s) not yet found - appears to use non-canonical splice consensus sequences; ATPase, putative; plasma membrane ATPase, putative
translation initiation factor IF-2, mitochondrial precursor, putative
HSK1 kinase regulatory subunit, putative
Similar to S. cerevisiae DBF4; S-phase/DNA repair modulator, putative
dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase, putative
extracellular matrix protein, putative; mannosyltransferase, putative
MAPKKK serine/threonine-protein kinase, putative
mitochondrial 54S ribosomal protein YmL49
SIT4 phosphatase complex subunit, putative
Similar to S. cerevisiae PHS1; putative signal anchor over residues 1-39 (SignalP); sphingolipid biosynthesis effector, putative
Similar to S. cerevisiae PHS1; sphingolipid biosynthesis effector, putative
flavin-containing monooxygenase, putative
mitochondrial import inner membrane translocase subunit, putative
putative LPF gene family member; frameshifted, degenerate and fragmented pseudogene
putative LPF gene family member; frameshifted and degenerate pseudogene; possibly Candida-specific
Similar to S. cerevisiae HHO1; spliced gene
pyridoxamine 5'-phosphate oxidase, putative
DNA-binding protein TRF1 homologue, putative
Not present in C. albicans; Possibly of plasmid origin - see Fasta hits; Similar to K. lactis TRF1 from cytoplasmic plasmid pGKL2; unlikely to be functional gene - no apparent translational start codon; terminal region recognition factor, putative
CTA2 subfamily 1 protein 5 orthologue, putative
Similar to C. albicans CTA2; apparent member of the TLO gene family which, in C. albicans, consists of at least 15 genes in a predominantly telomere-proximal location; only two members of this family are found in C. dubliniensis; transcriptional activator, putative
fungal zinc cluster transcription factor, putative
glucose-induced degradation protein, putative
Similar to S. cerevisiae GID7; In S. cerevisiae: involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase
protein disulfide-isomerase precursor, putative
peroxisomal intrinsic membrane protein,putative
Similar to Homo sapiens PXMP4; peroxisomal membrane protein, putative
polysome-associated RNA binding protein, putative
apparent fusion of orf19.5128 (Q5A5M4) + orf19.5126 (Q5A5F6)
orf19 number not been updated in corresponding UniProt entry (Q3MP25)
RNA polymerase II mediator complex subunit, putative
Similar to S. cerevisiae SIN4; global transcriptional regulator, putative; inducible polII transcriptional machinery effector, putative; subunit of the Mediator complex, dispensible for basal transcription, putative
glycine hydroxymethyltransferase, putative
Similar to S. cerevisiae SHM1; serine hydroxymethyltransferase, mitochondrial precursor, putative; serine methylase, putative
NADPH-dependent alpha-keto amide reductase, putative
conjugated polyketone reductase, putative
Similar to S. cerevisiae PRC1; proteinase C, putative; vacuolar carboxypeptidase Y precursor, putative
Similar to S. cerevisiae PUP3; multicatalytic endopeptidase complex subunit, putative; proteasome component, putative
DEAD-box ATP-dependent RNA helicase, putative
Similar to S. cerevisiae MTR4; mRNA export/exosome component, putative
Similar to S. cerevisiae SNG1; multidrug/nitrosoguanidine resistance protein, putative
hypothetical protein, Candida conserved, degenerate frameshifted pseudogene, putative; putative LPF gene family member; frameshifted and degenerate pseudogene, putative
guanyl nucleotide exchange factor, putative
vesicular trafficking Rab GTPase-activating protein, putative
calcineurin-like phosphoesterase, putative
metallophosphoesterase, putative; serine/threonine protein phosphatase, putative
Similar to S. cerevisiae PNC1; In S. cerevisiae: life span mediator; nicotine deamidase, putative
Similar to S. cerevisiae ISY1; spliceosome/PRP19 complex subunit, putative
Similar to C. albicans ARG4; arginosuccinase, putative
putative LPF gene family member; fragmented pseudogene
Similar to Kluyveromyces lactis TRF1; encoded by linear plasmid in K. lactis and others; see refs. to P05476; terminal region recognition factor 1, putative
Similar to S. cerevisiae DED81; asparaginyl-tRNA synthetase, cytoplasmic, putative
Similar to S. cerevisiae SLM5; asparaginyl-tRNA synthetase, mitochondrial precursor, putative
Similar to S. cerevisiae TIM9; spliced gene
Product identification made on basis of Pfam hit. CGD identification of this as S. cerevisiae GCN5 orthologue is not supported by Fasta/BlastP alignments
early Golgi alpha-1,2-mannosyltransferase, putative
MATE family drug/sodium antiporter, putative
nucleolar (U3 and U14) snoRNA-binding protein, putative
Similar to S. cerevisiae ENP1; In S. cerevisiae: required for pre-rRNA processing and 40S ribosomal subunit synthesis
1--phosphatidylinositol-4,5-bisphosphate phosphodiesterase 1, putative
phosphoinositide phospholipase c, putative; phospholipase c-1, putative
imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative
Tca-like retrotransposon GAG protein, putative
anti-telomeric silencing protein, putative
Similar to S. cerevisiae YAF9; subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, putative
has front and back ends but most of internal region deleted. Epsilon inserted in 3' UTR
mitochondrial 54S ribosomal protein YmL2
protein involved in retention of membrane proteins in the ER, putative
Similar to S. cerevisiae RER1; Similar to S. pombe RER1; retrieval receptor, returning membrane proteins to the ER, putative
adaptor protein that links actin to clathrin and endocytosis, putative
Similar to S. cerevisiae SLA2; SpEND4; endocytosis protein, putative; transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization, putative
Similar to S. cerevisiae PAA1; In S. cerevisiae: acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication via regulation of levels of polyamines bound to chromosomal DNA
sorting assembly machinery (SAM) complex subunit of the mitochondrial outer membrane, putative
In S. cerevisiae: binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane; Similar to S. cerevisiae SAM35
CCR4/NOT1 complex homologue conserved subunit, putative
Similar to S. pombe RCD1; Similar to S. cerevisiae CAF40; In S. cerevisiae: evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; cellular differentiation regulator, putative; transcripional regulator, putative
intranuclear transport/DNA replication mediator, putative
Similar to S. cerevisiae NOC3; nucleolar complex subunit, putative
Similar to S. cerevisiae PRB1; proteinase YSCB, putative; vacuolar serine protease, putative
Similar to S. cerevisiae UBC2; In S. cerevisiae: involved in post-replication repair, sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation; represses yeast to hypha transition; spliced gene; ubiquitin carrier protein, putative; ubiquitin-conjugating enzyme E2, putative; ubiquitin-protein ligase, putative
uncharacterized vacuolar protein, putative
mitochondrial N-glycosylase/DNA lyase [includes: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase], putative
Similar to S. cerevisiae OGG1; In S. cerevisiae: repairs oxidative damage to mitochondrial DNA
mitochondrial matrix acidic protein, putative
Similar to S. cerevisiae MAM33; In S. cerevisiae: involved in oxidative phosphorylation
G2/mitotic-specific (B-type) cyclin, putative
histone acetyltransferase subunit, putative
vacuolar protein sorting protein, late endosomal, putative
Similar to S. cerevisiae TAN1; In S. cerevisiae: RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs, putative
Similar to S. cerevisiae SSC1; heat shock protein [SSC1], mitochondrial precursor, putative; mitochondrial matrix ATPase, putative
Similar to S. cerevisiae PRE5; multicatalytic endopeptidase complex subunit, putative; proteasome component [alpha type 1], putative; proteinase YSCE subunit, putative
Similar to S. cerevisiae KAP120; In S. cerevisiae: role in the assembly or export of 60S ribosomal subunits; karyopherin, putative
nicotinate phosphoribosyltransferase, putative
Similar to S. cerevisiae HLJ1; ER-associated protein degradation (ERAD) modulator, putative; HSP40 co-chaperone, putative
hypothetical aspartic acid-rich protein, Candida conserved
Fasta hits unreliable due to high aspartic acid content of the protein
uncharacterized protein YGR110W homologue, putative
eukaryotic translation initiation factor 2 (eIF2), beta subunit, putative
cytoplasmic ankyrin-repeat protein, putative
uncharacterized protein YMR185W homologue, putative
Similar to S. cerevisiae FAA2; long chain fatty acyl-CoA ligase, putative; long chain fatty acyl-CoA synthetase, putative
U3 small nucleolar RNA-associated protein, putative
Similar to S. cerevisiae UTP18; U3 snoRNA-associated protein, putative
Similar to S. cerevisiae LOS1; nuclear pre-tRNA export pore protein, putative
Similar to S. pombe CYS11; cysteine synthase 1, putative; o-acetylserine (thiol)-lyase 1, putative; o-acetylserine sulfhydrylase 1, putative
NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans
uncharacterized protein YMR258C homologue, putative
In S. cerevisiae: recognizes spermine, putrescine and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; Similar to S. cerevisiae TPO1
Similar to S. cerevisiae HBS1; spliced gene; appears to be no intron TACTAAC box; elongation factor 1 alpha-like protein, putative
ER membrane fusion/vesicular trafficking t-SNARE integral membrane protein, putative
S-adenosylmethionine-dependent methyltransferase, putative
transcription elongation, nucleosome (dis)assembly factor, putative
gamma-butyrobetaine hydroxylase, putative
Similar to S. cerevisiae FMP12; uncharacterized oxidoreductase
Golgi integral membrane protein, putative
ATP-dependent DEAD-box RNA helicase, ribosome assembly, putative
retrotransposon:partial Tcd16 (subtelomeric), LTR
non-LTR retrotransposon Zorro-like polyprotein fragment, putative
Similar to C. albicans YRF1, (HPR5); incomplete sequence, apparent frame-shifts; probable pseudogene