Candida dubliniensis CD36 chromosome 6, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992693.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
Similar to C. albicans YRF1, (HPR5); incomplete sequence; apparent frameshifts; probably pseudogene
retrotransposon:solo LTR, iota P (subtelomeric)
Tcd3 retrotransposon gag protein, putative
gypsy-like/Tcd3 retrotransposon gag protein, putative; transposable element; Tcd21-like Gag & PR ORFs + duplicated fragment (subtelomeric)
regulator of Ty1 transposition, putative
ubiquitin carboxyl-terminal hydrolase, putative
Similar to S. cerevisiae UBP3; In S. cerevisiae: ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; ubiquitin thioesterase, putative
Similar to S. cerevisiae SPI1; Similar to C. albicans PGA48
D-arabinitol 2-dehydrogenase [ribulose-forming], putative
D-arabitol is a marker for active Candida infection in humans; Similar to S. cerevisiae SPS19 (peroxisomal 2,4-dienoyl-CoA reductase); NAD-dependent D-arabitol dehydrogenase, putative
Similar to S. cerevisiae HPA3; In S. cerevisiae: D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
vacuolar import and degradation protein, putative
Similar to S. cerevisiae VID27; possibly fungus-specific
SGD describes this as an orthologue of S. cerevisiae SFG1 (putative transcription factor required for growth of superficial pseudohyphae), but Fasta/BlastP hits don't support this
Similar to Podospora anserina het-c2; possibly involved in ascospore production; see Saupe et al. (1994). 'Inactivation of the Podospora anserina vegetative incompatibility locus het-c, whose product resembles a glycolipid transfer protein, drastically impairs ascospore production.' PNAS 91: 5927-5931.
acetate non-utilizing protein, mitochondrial precursor, putative
Similar to S. cerevisiae ACN9; In S. cerevisiae: protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis
conserved hypothetical protein; possibly fungal-conserved
Similar to S. cerevisiae FLO11; hyphally-regulated cell wall protein, putative; proteophosphoglycan, putative
diacylglycerol pyrophosphate (DGPP) phosphatase, putative
Similar to S. cerevisiae DPP1; In S. cerevisiae: diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
vacuolar morphogenesis protein, putative
Similar to S. cerevisiae VAM7; In S. cerevisiae: component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
uncharacterized vacuolar membrane protein YNL115C, putative
Similar to S. cerevisiae DMA2 (CHF2); protein involved in regulating spindle position and orientation, putative
conserved hypothetical protein; possibly Candida-specific
myc-type bHLH transcription factor, putative
In C. albicans: basic helix-loop-helix transcription factor that regulates hyphal development partly via TEC1; transcriptional activator of hyphal growth, putative
vacuolar ATP synthase subunit A, golgi isoform, putative
Similar to S. cerevisiae STV1; In S. cerevisiae: subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
ERAD-associated E3 ubiquitin-protein ligase component, putative
Similar to S. cerevisiae HRD3; In S. cerevisiae: resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; HMG-CoA reductase degradation protein, putative
DNA replication ATP-dependent helicase, putative
Similar to S. cerevisiae DNA2; In S. cerevisiae: essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
high-affinity glutamine permease, putative
mitochondrial intermediate peptidase, mitochondrial precursor, putative
Similar to S. cerevisiae OCT1; In S. cerevisiae: mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
serine/threonine-protein kinase, putative
Similar to S. cerevisiae PKH3; In S. cerevisiae: protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p
uncharacterized protein YBL107C orthologue, putative
Similar to S. cerevisiae NOP58; In S. cerevisiae: protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
putative seryl-tRNA synthetase, putative
Similar to S. cerevisiae DIA4; In S. cerevisiae: probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
SGD describes this gene as an orthologue of S. cerevisiae USO1, but this is not supported by Fasta/BlastP alignments
exocytosis and cation homeostasis regulatory protein, putative
possibly fungal-specific; Similar to S. cerevisiae SNI2 (SRO77); In S. cerevisiae: protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; interacts with SNARE protein Sec9p
dolichol phosphate-mannose biosynthesis regulatory subunit, putative
Similar to Mus musculus Dpm2; spliced gene
AP-3 adapter complex mu3A subunit, putative
Similar to S. cerevisiae APM3; In S. cerevisiae: mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; AP-3 complex subunit mu, putative
iron transport multicopper oxidase precursor, putative
Similar to C. albicans FET3; Similar to S. cerevisiae FET3; In C. albicans: multicopper oxidase; required for growth under low-iron conditions; In S. cerevisiae: ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
NEDD8-activating enzyme E1 catalytic subunit, putative
Similar to S. cerevisiae UBA3; In S. cerevisiae: protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; ubiquitin-like protein-activating enzyme, putative
DNA repair and recombination protein, putative
In C. albicans: required for wild-type repair of UV-or MMS-damaged DNA, for homologous DNA recombination, and for wild-type telomere length; constitutively expressed, MMS-induced; weakly complements S. cerevisiae rad52 mutant; DNA binding region conserved; In S. cerevisiae: protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
small nuclear ribonucleoprotein E (snRNP-E), putative
Similar to S. cerevisiae MUS81; In S. cerevisiae: helix-hairpin-helix protein, involved in DNA repair and replication fork stability; crossover junction endonuclease, putative
mitochondrial ribosomal protein, small subunit, putative
Similar to S. cerevisiae PET123; In S. cerevisiae: mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
Similar to S. cerevisiae NDC1; In S. cerevisiae: nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II; nucleoporin, putative
mitochondrial sodium/hydrogen exchanger, putative
Similar to S. cerevisiae NHX1 (NHA2); In S. cerevisiae: endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock; vacuolar protein sorting-associated protein, putative
ER-to-Golgi transporter protein, putative
mitochondrial DNA replication protein, putative
Similar to S. cerevisiae YHM2; In S. cerevisiae: mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family; mitochondrial carrier family protein, putative
In S. cerevisiae: cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); spliced gene; cytosine deaminase, putative
RNA polymerase II transcription factor B subunit 4, putative
Similar to S. cerevisiae TFB4; In S. cerevisiae: subunit of TFIIH complex, involved in transcription initiation; TFIIH subunit TFB4, putative
cofilin/tropomyosin family protein, putative
Similar to S. cerevisiae AIM7; Similar to S. pombe SPAC17H9.11; spliced gene
protein phosphatase required for mitotic exit, putative
In C. albicans: protein involved in exit from mitosis and morphogenesis; ortholog of S. cerevisiae Cdc14p, which is a dual-specificity phosphatase and cell-cycle regulator; In S. cerevisiae: protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; spliced gene; tyrosine-protein phosphatase CDC14, putative
vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae VTA1; spliced gene
conserved hypothetical protein; possibly fungus-conserved
RNA polymerase II-associated protein, putative
uncharacterized membrane protein YER140W orthologue, putative
In S. cerevisiae: the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
cytochrome c oxidase assembly protein, putative
Similar to S. cerevisiae COX15; In S. cerevisiae: protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
very long-chain fatty acid transport protein, putative
Similar to S. cerevisiae FAT1; In S. cerevisiae: fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; very long-chain fatty acyl-CoA synthetase, putative
catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
hsp70 nucleotide exchange factor, putative
Similar to S. cerevisiae FES1; In S. cerevisiae: Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
DNA recombination and repair protein, putative
Similar to S. cerevisiae MMS4; spliced gene; crossover junction endonuclease, putative
In S. cerevisiae: high-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
conserved hypothetical protein; possibly fungus-conserved; in CGD, orf19.3643 is described as being orthologous to S. cerevisiae STP2, but this is not suported by Fasta/BlastP alignments
Septation protein SUN4 [Precursor], putative
Similar to S. cerevisiae SUN4; In S. cerevisiae: cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family; In C. albicans: putative cell wall glycosidase involved in biofilm formation, morphogenesis and cell wall biogenesis; hyphal induced; required for virulence; caspofungin repressed; cell wall glycosidase, putative; septation protein precursor, putative; soluble cell wall protein, putative
In S. cerevisiae: plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; spliced gene; lysine/arginine permease, putative
hydrogen peroxide resistance protein, putative
Similar to S. cerevisiae HYR1; In S. cerevisiae: thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels; peroxiredoxin, putative; thiol peroxidase, putative
acetohydroxy-acid reductoisomerase, putative
Similar to S. cerevisiae ILV5; alpha-keto-beta-hydroxylacid reductoisomerase, putative; ketol-acid reductoisomerase, mitochondrial precursor, putative
Similar to S. cerevisiae PEX7; In S. cerevisiae: peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; peroxisomal import protein, putative; peroxisomal targeting signal receptor, putative
uncharacterized protein YFL042C orthologue, putative
uncharacterized protein YGR053C orthologue, putative
uncharacterized protein YFR016C orthologue, putative
mitochondrial intermembrane space cysteine motif protein, putative
In C. albicans: DNA topoisomerase I; required for wild-type growth and for wild-type mouse virulence; In S. cerevisiae: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
In S. cerevisiae: plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; lysine/arginine permease, putative
3'(2'),5 bisphosphonucleoside 3'(2')-phosphohydrolase, putative
Similar to S. cerevisiae MET22 (HAL2); In S. cerevisiae: bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; 3'(2'),5'-bisphosphate nucleotidase, putative
appears to be a fusion of orf19.103 and orf19.104; Similar to S. cerevisiae KAR5; In S. cerevisiae: protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone; In C. albicans: induced by alpha factor; nuclear fusion protein, putative
3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, putative
probable ATP-dependent RNA helicase, putative
Similar to S. cerevisiae DHR2; In S. cerevisiae: predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
Similar to S. cerevisiae MSY1; tyrosyl-tRNA synthetase, mitochondrial precursor, putative
NmrA-like negative transcriptional regulator, putative
contains the Pfam PF05368 domain (NmrA-like family); NmrA is a negative transcriptional regulator involved in nitrogen metabolite repression in fungi; it shows unexpected similarity to the short-chain dehydrogenase/reductase (SDR) family, although it is unlikely to be an active dehydrogenase, due to the absence of certain essential conserved catalytic residues; shows some sequence similarity to plant isoflavone reductases and phenylcoumaran benzylic ether reductases; oxidoreductase, putative
appears to be a fusion of orf19.114 and orf19.115; spliced gene
Similar to S. cerevisiae SEC9; In S. cerevisiae: t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; t-SNARE protein, putative
delta 12-fatty acid desaturase, putative
Similar to Pichia pastoris FAD2; In C. albicans: involved in production of linoleic acid, which is a major component of membranes
farnesyl cysteine-carboxyl methyltransferase, putative
Similar to S. cerevisiae STE14; In S. cerevisiae: farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; isoprenylcysteine carboxylmethyltransferase, putative; prenylcysteine carboxyl methyltransferase, putative; protein-S-isoprenylcysteine O-methyltransferase, putative
quoted orthologue was deleted from CGD Assembly 20, but definitely appears to be an ORF in the relevant region of C. albicans chromosome 6; possible annotation error in CGD?; Similar to S. cerevisiae STE14; In S. cerevisiae: farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; isoprenylcysteine carboxylmethyltransferase, putative; prenylcysteine carboxyl methyltransferase, putative; protein-S-isoprenylcysteine O-methyltransferase, putative
Similar to S. cerevisiae ARC18; In S. cerevisiae: subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
Similar to S. cerevisiae CDC20; In S. cerevisiae: cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate; cell division control protein, putative
Similar to S. cerevisiae RCN1; In S. cerevisiae: protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region; regulator of calcineurin, putative
proteasome-interacting protein, putative
Similar to S. cerevisiae CIC1; In S. cerevisiae: essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity
Similar to S. cerevisiae OYE2; In C. albicans: interacts with phenolic substrates, such as 17beta-estradiol; possible role in response to estrogen; induced by oxidative stress (via Cap1p), nitric oxide, benomyl; no human or murine homolog; In S. cerevisiae: widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; estrogen-binding protein, putative
Similar to S. cerevisiae VPS15; In S. cerevisiae: myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; vacuolar protein sorting-associated protein, putative
bad response to refrigeration (BRR) protein, putative
Similar to S. cerevisiae BRR1; In S. cerevisiae: snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; pre-mRNA-splicing factor, putative
uncharacterized protein YPR063C orthologue, putative
Similar to S. cerevisiae SIF2; In S. cerevisiae: WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
Similar to S. cerevisiae EXO84; In S. cerevisiae: essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex mediates polarized targeting of secretory vesicles to active sites of exocytosis; exocyst complex component, putative
uncharacterized multidrug transporter, putative
Similar to S. cerevisiae QDR3; In S. cerevisiae: multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; uncharacterized transporter of the major facilitator superfamily, putative
uncharacterized acyltransferase, putative
Similar to S. cerevisiae CST26; In S. cerevisiae: protein of unknown function, affects chromosome stability when overexpressed
integral membrane protein required for mating, putative
Similar to S. cerevisiae FIG1; In S. cerevisiae: integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; In C. albicans: transcription is opaque-specific, a-specific, and activated by Cph1p or alpha pheromone
Similar to S. cerevisiae TRA1; In S. cerevisiae: subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
uncharacterized protein YHR100C orthologue, putative
In S. cerevisiae: putative mitochondrial protein; required for respiratory growth; spliced gene
RING finger-containing protein, putative
zinc finger-containing protein, putative
component of glycosylphosphatidylinositol-mannosyltransferase, putative
Similar to S. cerevisiae PBN1; In S. cerevisiae: essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
Similar to S. cerevisiae MOG1; In S. cerevisiae: conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
Similar to S. cerevisiae HOC1; In S. cerevisiae: alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; glycosyltransferase, putative
Similar to S. cerevisiae AZR1; In S. cerevisiae: plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; transporter protein of the major facilitator superfamily, putative
Similar to S. cerevisiae OYE2; In C. albicans: oxidoreductase that binds mammalian oestrogens with high affinity; estrogen-binding protein, putative
Similar to S. cerevisiae OYE2; old yellow enzyme, putative
Similar to S. cerevisiae FUN34; In S. cerevisiae: putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies
Similar to C. albicans FRP5 (FUN34); Similar to S. cerevisiae ATO2 (FUN34); In S. cerevisiae: ATO2 is a putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies
Similar to S. cerevisiae SCJ1; In S. cerevisiae: one of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
Rho GDP-dissociation inhibitor, putative
Similar to S. cerevisiae RDI1; In S. cerevisiae: Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
uncharacterized zinc finger protein, putative
appears to be a fusion of orf19.3434 and orf19.3435
Similar to S. cerevisiae OYE2; In S. cerevisiae: widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism; In C. albicans: oxidoreductase that binds, and is inhibited by, mammalian oestrogens; estrogen-binding protein, putative; old yellow enzyme, putative
uncharacterized membrane transporter protein of the major facilitator superfamily, putative
Similar to S. cerevisiae MIP1; In S. cerevisiae: catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mitochondrial DNA polymerase catalytic subunit, putative
eukaryotic translation initiation factor 5a (eIF-5A), putative
In S. cerevisiae: ranslation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modification; In C. albicans:utative translation initiation factor; decreased expression in hyphae compared to yeast-form cells; Similar to S. cerevisiae HYP1/HYP2; spliced gene
eukaryotic translation initiation factor 4B (eIF-4B), putative
Similar to S. cerevisiae TIF3; In S. cerevisiae: translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
subunit of the RNA polymerase II mediator complex, putative
Similar to S. cerevisiae ROX3; spliced gene; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme
uncharacterized mitochondrial protein, putative
Similar to S. cerevisiae FMP27; In S. cerevisiae: the non-tagged protein is detected in highly purified mitochondria in high-throughput studies
NAD-dependent malic enzyme, mitochondrial precursor, putative
Similar to S. cerevisiae MAE1; In S. cerevisiae: mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
Similar to S. cerevisiae CAR1; In S. cerevisiae: responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
In S. cerevisiae: intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
Similar to S. cerevisiae RPL32; spliced gene
serine/threonine protein kinase, putative
Similar to S. cerevisiae PTK2; In S. cerevisiae: putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
Similar to S. cerevisiae SUR7; In S. cerevisiae: putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants; integral membrane protein, putative
in-frame stop codons; apparent genomic rearrangement; Similar to C. albicans FGR37; C. albicans orthologue described as filamentous growth regulator (FGR) protein
Similar to S. cerevisiae ATG15; In S. cerevisiae: lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; possibly fungus-specific; cytoplasm to vacuole targeting protein, putative; lipase, putative
guanine nucleotide-exchange factor, putative
Similar to S. cerevisiae SEC12; In S. cerevisiae: guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p; protein transport protein, putative
postreplication repair E3 ubiquitin-protein ligase, putative
Similar to S. cerevisiae RAD18; In S. cerevisiae: protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; radiation sensitivity protein, putative
transcription factor with zinc finger DNA-binding motif, putative
Similar to C. albicans ZCF18; spliced gene
formamidopyrimidine-DNA glycosylase, putative
vacuolar protein-sorting-associated protein, putative
Similar to S. cerevisiae VPS60; In S. cerevisiae: cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation
Similar to S. cerevisiae COQ3; In S. cerevisiae: O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor, putative
Similar to S. cerevisiae VPS72; In S. cerevisiae: Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
Similar to S. cerevisiae HCH1; In S. cerevisiae: heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; spliced gene; hsp90 regulator, puative
membrane transport protein of the major facilitator superfamily, putative
Similar to S. cerevisiae YHK8; In S. cerevisiae: presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
Similar to S. cerevisiae DBP9; In S. cerevisiae: ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit; ribosome biogenesis protein, putative
2-deoxyglucose-6-phosphate phosphatase, putative
Similar to S. cerevisiae DOG2; In S. cerevisiae: 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
Similar to S. cerevisiae ADK1; In S. cerevisiae: adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; adenylate kinase cytosolic, putative
Similar to S. cerevisiae PCF11; In S. cerevisiae: mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
mitochondrial GTP/GDP transporter, putative
Similar to S. cerevisiae YHM1; In S. cerevisiae: mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family; mitochondrial carrier protein, putative
uncharacterized protein YNL193W orthologue, putative
Similar to S. cerevisiae RPL25; spliced gene; In S. cerevisiae: primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit
mitochondrial 37S ribosomal protein YmS18
Similar to S. cerevisiae MRPS18; In S. cerevisiae: mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
In S. cerevisiae: phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; phospholipase B, putative
Similar to S. cerevisiae PLB3; In S. cerevisiae: phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; phospholipase B, putative
NAD-dependent glycerol-3-phosphate dehydrogenase, putative
Similar to S. cerevisiae GPD1; In S. cerevisiae: NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway
NADH-cytochrome b5 reductase precursor, putative
Similar to S. cerevisiae MCR1; In S. cerevisiae: involved in ergosterol biosynthesis
Similar to S. cerevisiae DBR1; In S. cerevisiae: RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition; calcineurin-like phosphoesterase, putative
phosphatidylinositol 4,5-bisphosphate effector protein, putative
Similar to S. cerevisiae SLM2; In S. cerevisiae: phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress
Similar to S. cerevisiae RPL23A/B; spliced gene
uncharacterized protein YKL098W orthologue, putative
Similar to S. cerevisiae CHC1; In S. cerevisiae: clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
Similar to S. cerevisiae MCM21; In S. cerevisiae: potein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; chromosome transmission fidelity protein, putative; minichromosome maintenance protein, putative
inner membrane magnesium transporter, mitochondrial precursor, putative
Similar to S. cerevisiae LPE10; In S. cerevisiae: mitochondrial inner membrane magnesium transporter, involved in maintenance of magnesium concentrations inside mitochondria; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
Similar to S. cerevisiae KIC1; In S. cerevisiae: protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
subunit of the COMPASS complex, putative
Similar to S. cerevisiae SWD3; In S. cerevisiae: essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
Similar to S. cerevisiae VPS68; In S. cerevisiae: vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
meiosis and centromere regulator kinase, putative
Similar to S. cerevisiae MCK1; In S. cerevisiae: protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; protein kinase, putative
In S. cerevisiae: GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport; spliced gene
Similar to S. cerevisiae LSG1; In S. cerevisiae: putative GTPase involved in 60S ribosomal subunit biogenesis
ribosomal RNA methyltransferase, mitochondrial precursor, putative
Similar to S. cerevisiae MRM2; In S. cerevisiae: mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA
beta'-coat protein of the COPI coatomer, putative
In S. cerevisiae: involved in ER-to-Golgi and Golgi-to-ER transport; Similar to S. cerevisiae SEC27
Similar to S. cerevisiae ALG11; In S. cerevisiae: alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER; asparagine-linked glycosylation protein, putative
Similar to S. cerevisiae STB1; In S. cerevisiae: protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated; similarity with S. cerevisiae STP1 is weak
tRNA wybutosine-synthesizing protein, putative
Similar to S. cerevisiae TYW1; In S. cerevisiae: protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
subunit of SAGA histone acetyltransferase complex, putative
Similar to S. cerevisiae SGF73; In S. cerevisiae: subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
Similar to S. cerevisiae IPL1; In S. cerevisiae: aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; spindle assembly checkpoint kinase, putative
Similar to S. cerevisiae HRR25; In S. cerevisiae: protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta); serine/threonine protein kinase, putative
Similar to S. cerevisiae PUS1; In S. cerevisiae: tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA; spliced gene; tRNA pseudouridine synthase, putative; tRNA pseudouridylate synthase, putative
Similar to S. cerevisiae NIP7; In S. cerevisiae: nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles
Similar to S. cerevisiae RSM23; In S. cerevisiae: mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins
ATP-dependent RNA helicase, mitochondrial precursor, putative
Similar to S. cerevisiae MRH4; mitochondrial RNA helicase, putative
NADH diphosphatase (pyrophosphatase), putative
Similar to S. cerevisiae NPY1; In S. cerevisiae: NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
glycerophosphodiester phosphodiesterase, putative
In S. cerevisiae: protein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs
chromatin remodelling complex subunit, putative
Similar to S. cerevisiae ITC1; In S. cerevisiae: component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
Similar to S. cerevisiae PRP45; In S. cerevisiae: protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
ubiquinol cytochrome-c reductase complex assembly protein, putative
Similar to S. cerevisiae CBP3; In S. cerevisiae: mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex)
signal recognition particle subunit, putative
Similar to S. cerevisiae SRP72; In S. cerevisiae: core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
NADP-dependent alcohol dehydrogenase, putative
Similar to S. cerevisiae ADH7; In S. cerevisiae: NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
aminomethyltransferase, mitochondrial precursor, putative
Similar to S. cerevisiae GCV1; In S. cerevisiae: T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm; glycine decarboxylase complex subunit, putative
Similar to S. cerevisiae ISA1; In S. cerevisiae: mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency
best Fasta hit with C. albicans shows only 38% sequence identity, but is wrong size - don't think it can be considered an orthologue, therefore, this gene may be C. dubliniensis-specific
uncharacterized oxidoreductase, putative
secretory vesicle transport protein, putative
In C. albicans: involved in the retrograde secretory secretory pathway; In S. cerevisiae: membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER
Similar to S. cerevisiae NGL2; In S. cerevisiae: protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; rRNA processing protein, putative
Similar to S. cerevisiae MOB1; component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; kinase activator protein, putative
nuclear polyadenylated RNA-binding protein, putative
Similar to S. cerevisiae NAB3; In S. cerevisiae: single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; single stranded RNA binding protein, putative
In S. cerevisiae: essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; In C. albicans: interacts with the Crk1 kinase and is required for Crk1 production; cell division control protein, putative
ethanolamine utilization protein, putative
Similar to S. cerevisiae VPS9; In S. cerevisiae: a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin; vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae TVP38; In S. cerevisiae: integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
Similar to S. cerevisiae FEN2; In S. cerevisiae: plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
cell wall integrity and stress response protein, putative
Similar to S. cerevisiae TEL1; In S. cerevisiae: protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene; serine/threonine-protein kinase, putative; telomere length regulation protein, putative
In S. cerevisiae: pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1; pantothenic acid kinase, putative
Similar to S. cerevisiae PEX25; In S. cerevisiae: peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p; peroxisomal membrane protein, putative
In S. cerevisiae: putative cysteine synthase, localized to the mitochondrial outer membrane; O-acetylserine sulfhydrylase, putative; cysteine synthase, putative
Similar to Yarrowia lipolytica ANL1; In S. cerevisiae: subunit of Golgi mannosyltransferase complex that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; alpha 1-6 mannosyltransferase, putative; mannan polymerase complexes MNN9 subunit, putative
inner nuclear membrane (INM) protein, putative
Similar to S. cerevisiae HEH2; spliced gene
weak similarity to ScVPS51 noted, but unconvincing
Similar to S. cerevisiae POP4; In S. cerevisiae: subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P; subunit of RNase MRP and of nuclear RNase P, putative
Similar to Homo sapiens LIPT1; catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; lipoate protein ligase, putative; lipoyl ligase, putative; lipoyltransferase 1, mitochondrial precursor, putative
3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor, putative
in-frame stop codons; Similar to S. cerevisiae RNH1
Similar to S. cerevisiae RNH1; In S. cerevisiae: ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand
a-factor pheromone maturation protease, putative
annotated as RAV2 in CGD and orf19.5559 is annotated as STE23 - annotation error?; Similar to S. cerevisiae STE23; In S. cerevisiae: metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family; a-factor-processing enzyme, putative
regulator of (H+)-ATPase in vacuolar membrane, putative
Similar to S. cerevisiae RAV2; annotated as STE23 in CGD - annotation error?; In S. cerevisiae: subunit of RAVE (regulator of (H+)-ATPase in vacuolar membrane), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
RPG-box-Binding transcription factor, putative
In C. albicans: DNA-binding protein that functions as a transcription factor and/or a telomere-length regulator in C. albicans; transcription factor with telomere-binding activity, putative
positive regulator of mannosyltransferase, putative
Similar to S. cerevisiae MNN4; In S. cerevisiae: putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides
uncharacterized protein YKL069W orthologue, putative
Similar to S. cerevisiae MIF2; In S. cerevisiae: kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p; kinetochore protein, putative
Similar to S. cerevisiae MRT4; In S. cerevisiae: protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
transcription factor with zinc cluster DNA-binding motif, putative
Similar to S. cerevisiae LYS14; In S. cerevisiae: transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway
From PFAM: proteins in this family have been identified as a component of the higher eukaryotic NADH complex
fimbrin (actin bundling protein), putative
Similar to S. cerevisiae SAC6; In S. cerevisiae: fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
Similar to S. cerevisiae PEP3; Similar to C. albicans VPS18; vacuolar protein sorting-associated protein, putative
In C. albicans: hyphal secreted aspartyl proteinase required for wild-type virulence; The C. dubliniensis entry for this gene (UniProt: BlastP analysis (CGD website) reveals that it has greater sequence similarity to SAP6 than to SAP4 (82% sequence identity, as opposed to 81%. Accordingly, it has been annotated here as SAP6); secreted aspartyl proteinase, putative
In C. albicans: secreted aspartyl protease required for wild-type virulence in a systemic mouse model
external NADH-ubiquinone oxidoreductase, mitochondrial precursor, putative
Similar to S. cerevisiae NDE1; In S. cerevisiae: a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; Similar to S. cerevisiae NDE2; mitochondrial external NADH dehydrogenase, putative
phosphatidylinositol transfer protein, putative
Similar to S. cerevisiae CSR1; In S. cerevisiae: phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance
component of the nuclear pore complex, putative
mitochondrial leucyl-tRNA synthetase, putative
In S. cerevisiae: mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
uncharacterized protein YGR150C orthologue, putative
uncharacterized protein YOR093C orthologue, putative
Similar to S. cerevisiae CTF3; In S. cerevisiae: outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; chromosome transmission fidelity protein, putative
5',5'''-P-1,P-4-tetraphosphate phosphorylase, putative
Similar to S. cerevisiae APA2; In S. cerevisiae: involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase, putative
cytochrome b-c1 complex subunit, putative
Similar to S. cerevisiae QCR7; In S. cerevisiae: subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; subunit of the ubiquinol-cytochrome c reductase complex, putative
mitochondrial dicarboxylate transporter, putative
Similar to S. cerevisiae DIC1; In S. cerevisiae: mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix; spliced gene
Similar to S. cerevisiae HEK2; In S. cerevisiae: RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
Similar to S. cerevisiae ARP4; In S. cerevisiae: nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
1,4-alpha-glucan-branching enzyme, putative
Similar to S. cerevisiae GLC3; In S. cerevisiae: glycogen branching enzyme, involved in glycogen accumulation; glycogen-branching enzyme, putative
uncharacterized protein YPR097W orthologue, putative
phenazine biosynthesis-like protein, putative
Similar to S. cerevisiae YHI9; uncharacterized isomerase, putative
Similar to S. cerevisiae LPF39; rearranged/degenerate pseudogene; in-frame stop codons
Similar to S. cerevisiae VPS45; In S. cerevisiae: protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
histone deacetylase complex subunit, putative
Similar to S. cerevisiae CTI6; In S. cerevisiae: protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; transcriptional regulatory protein, putative
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, putative
Similar to S. cerevisiae AYR1; In S. cerevisiae: NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones; acylglycerone-phosphate reductase, putative
Similar to S. pombe RNH1; In S. cerevisiae: ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand
NADPH-dependent methylglyoxal reductase, putative
carbamoylphosphate:L-ornithine carbamoyltransferase, putative
Similar to S. cerevisiae ARG3; In S. cerevisiae: catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine; ornithine carbamoyltransferase, putative
DNA-directed RNA polymerase III subunit, putative
Similar to S. cerevisiae RPC34; In S. cerevisiae: subunit specific to RNA Pol III, the tRNA specific polymerase; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
primary mechanism of fluconazole resistance in Candida dubliniensis; plasma membrane transporter of the major facilitator superfamily
ATP-dependent permease, mitochondrial precursor, putative
Similar to S. cerevisiae MDL1; In S. cerevisiae: mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter; mitochondrial ABC transporter; multidrug resistance-like protein, putative
ATP synthase catalytic sector F1 epsilon subunit
Similar to S. cerevisiae ATP15; In S. cerevisiae: epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
Similar to S. cerevisiae POL5; In S. cerevisiae: DNA Polymerase phi; not required for chromosomal DNA replication; required for the synthesis of rRNA; localised exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units; DNA polymerase phi, putative
uncharacterised protein YPR085C orthologue, putative
uncharacterized protein YBR130C orthologue, putative
Similar to S. cerevisiae SHE3; similarity with ScSHE3 is weak
Similar to S. cerevisiae ADO1; In S. cerevisiae: adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle; potential extended N-terminus - not supported by BlastP or Fasta alignments
In S. cerevisiae: F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; component of SCF ubiquitin ligase complexes, putative
retrotransposon polyprotein, pseudogene, putative
fragment of coding sequence; transposon pseudogene; transposable element
retrotransposon reverse transcriptase, pseudogene, putative
fragment of sequence; transposable element
hypothetical transposon protein, putative
phosphatidylinositol 3,5-bisphosphate 5-phosphatase, putative
Similar to S. cerevisiae FIG4; In S. cerevisiae: protein that forms a complex with Vac14p and is involved in turnover of PI3,5P2 (phosphatidylinositol 3,5-bisphosphate) after hyperosmotic shock; required for efficient mating; polyphosphoinositide phosphatase, putative
putative C. albicans orthologue has been withdrawn from CGD Assembly 20; possibly Candida-specific
Similar to S. cerevisiae MCH4; monocarboxylate permease, putative
uncharacterized protein YDR026C homologue, putative
Similar to S. cerevisiae POX1; In S. cerevisiae: involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; fatty-acyl coenzyme A oxidase, putative
catalyses hydroxylation of N-alkanes at the terminal position; N-alkane-inducible cytochrome P450, putative
zinc cluster DNA-binding protein, putative
identified as a regulator of filamentous growth: Uhl et al. (2003) EMBO J 22(11):2668-2678
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, putative
Similar to Aspergillus fischerianus NFIA_026010; this enzyme catalyses the third reaction in ubiquinone biosynthesis
phenylacrylic acid decarboxylase, putaytive
Similar to S. cerevisiae PAD1; In S. cerevisiae: phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives
Similar to S. cerevisiae NOG2; In S. cerevisiae: putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; spliced gene
Similar to S. cerevisiae POP2; In S. cerevisiae: mediates 3' to 5' mRNA deadenylation; subunit of the CCR4-NOT complex, putative
Similar to S. cerevisiae CDC50; In S. cerevisiae: endosomal protein that regulates cell polarity and controls polarized growth
PCR fragment cloned and sequenced by Hoyer, termed ALSD2: Hoyer et al. (2001) Genetics 157(4):1555-1567; syntenic with C. albicans ALS1 and ALS5 genes, but displays greater fasta homology to ALS1
shares high fasta homology and synteny with C. abicans ALS9
mitochondrial 37S ribosomal protein MRP4
Similar to S. cerevisiae SBA1; Similar to S. pombe WOS2; also similar to S. pombe WOS2 cell cycle regulatory protein; In S. cerevisiae: co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
cytoplasmic serine hydroxymethyltransferase, putative
In S. cerevisiae: involved in one-carbon metabolism; glycine hydroxymethyltransferase, putative
uncharacterized endoplasmic reticulum membrane protein, putative
Similar to S. cerevisiae ORM1; has the ORMDL family domain (Pfam PF04061); there is evidence to suggest that ORMDLs are involved in protein folding in the ER
Similar to S. cerevisiae SAF1; In S. cerevisiae: F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence
glucose transporter of the major facilitator superfamily, putative
In C. albicans: indentified by homology as a member of a large family of putative glucose transporters (HGT1 to HGT20), Fan et al. (2002) J Mol Evol 55(3):336-346
ADIPOR-like receptor IZH3 orthologue, putative
Similar to S. cerevisiae IZH3; In S. cerevisiae: membrane protein involved in zinc metabolism; implicated in zinc homeostasis protein, putative
Similar to S. cerevisiae PHO80; In S. cerevisiae: cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance; negative regulator of phosphate metabolism, putative
contains a probable molybdopterin binding domain (Pfam PF00994); this domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor; the domain is presumed to bind molybdopterin
serine/threonine-protein phosphatase, putative
Similar to S. cerevisiae PPQ1; phosphatase involved in the regulation of protein synthesis, putative
In C. albicans: protein detected at yeast-form cell plasma membrane by mass spec; multudrug resistance protein, putative
hypothetical GPI-anchored protein, putative
Similar to C. albicans IHD1; transcription induced during hyphal growth
hypothetical GPI-anchored protein, conserved
peroxisomal 2,4-dienoyl-CoA reductase, putative
Similar to S. cerevisiae SPS19; In S. cerevisiae: peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; sporulation-specific protein, putative
antiviral protein Ski8 orthologue, putative
Similar to S. cerevisiae SKI8; In S. cerevisiae: protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses; dsRNA virus inhibition protein, putative; mRNA degradation protein, putative
Similar to S. cerevisiae NUP82; nucleoporin, putative
Similar to S. cerevisiae CUS2; sequence similarity to partially characterised RNA binding protein CUS2; U2 snRNA binding protein, putative
SNF1 protein-kinase interacting protein, putative
Similar to S. cerevisiae SNF4; activator of glucose-repressible genes, putative; regulatory nuclear protein, putative
overexpression of OPT8 does not supress mutations in OPT1-3
Similar to S. cerevisiae PBP2; In S. cerevisiae: RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
Similar to S. cerevisiae SWC5; In S. cerevisiae: protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; chromatin remodeling protein, putative; histone exchange factor, putative
core RPS domain consists of a single partial RPS unit of 1535bp; orientation FT antisense
conserved hypothetical protein in Major Repeat Sequence (MRS), RB2 region; putative regulator of filamentous growth
RPS (RePeat Sequence) domain; single, partial RPS unit of 1535 bp
Similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS
Similar to S. cerevisiae ALG2; asparagine-linked glycosylation protein, putative
Similar to S. cerevisiae RVS167; In S. cerevisiae: actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; reduced viability upon starvation protein, putative
appears to be a fusion of orf19.1217 and orf19.1219; allelic variation; the region 891585..891647 bp (shown here) represents the long allele of this gene (5'-GAT AGT GGG AAA CAA CAA CAA CAA CAA CAA CAA CAG CAA CAG CAA GAC ACT GAA AAC AAC ATT -3'); the short allele (not shown) is: 5'-GAT AGT GGG AAA CAA CAA CAA CAA CAG CAA GAC ACT GAA AAC AAC ATT-3
Similar to S. cerevisiae MAP2; In S. cerevisiae: catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides
endoplasmic reticulum integral membrane protein, putative
In S. cerevisiae: required for inositol metabolism and regulation of phospholipid biosynthesis; Similar to S. cerevisiae SCS2; spliced gene; vesicle-associated membrane protein-associated protein, putative
vacuolar amino acid transporter, putative
Similar to S. cerevisiae SPC105; In S. cerevisiae: protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; spindle pole body component, putative
PCR fragment cloned and sequenced by Hoyer, termed ALSD3: Hoyer et al. (2001) Genetics 157(4):1555-1567; syntenic with and homologous to C. albicans ALS4
Similar to S. cerevisiae PEX11; In S. cerevisiae: peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane
nucleolar ribosome biogenesis protein, putative
Dol-P-Man-dependent alpha(1-3)-mannosyltransferase, putative
Similar to S. cerevisiae ALG3; In S. cerevisiae: involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; HM-1 killer toxin resistance protein, putative; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase, putative; protein amino acid glycosylation enzyme, putative
regulator of hyphal gene expression, putative
transcriptional regulatory protein, putative
Similar to S. cerevisiae POL90; transposable element
Similar to S. cerevisiae GLE2; In S. cerevisiae: component of the nuclear pore complex required for polyadenylated RNA export but not for protein import; subunit of the nuclear pore complex, putative
voltage-gated chloride channel, putative
Similar to S. cerevisiae GEF1; In S. cerevisiae: chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
homologous to and syntenic with C. albicans ALS2; This sequence is distinct from the C. dubliniensis PCR fragments cloned and sequenced by Hoyer, termed ALSD1-3: Hoyer et al. (2001) Genetics 157(4):1555-1567; this orf (Cd36_64800) and Cd36_65010 have high similarity to CaALS2; however, whereas Cd36_65010 is similar in length to CaALS2, Cd36_64800 contains two large internal insertions of ca. 432aa and 612aa respectively.
Similar to S. cerevisiae SPC105; possibly duplicated copy of orf Cd36_64607; In S. cerevisiae: protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; spindle pole body component, putative
Similar to S. cerevisiae AVT5; possible duplicated copy of orf Cd36_64604
retrotransposon:solo LTR, eta I, truncated
brefeldin-A sensitivity protein, putative
Similar to S. cerevisiae BRE5; In S. cerevisiae: ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A; de-ubiquitination complex subunit, putative; ubiquitin protease cofactor, putative; vesicle transport regulatory protein, putative
Similar to S. cerevisiae UBC1; ubiquitin-conjugating enzyme, putative; ubiquitin-protein ligase, putative
subunit of the CCR4-NOT transcriptional complex, putative
Similar to S. cerevisiae CDC39; In S. cerevisiae: putative orthologue encodes a component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor--negatively regulates transcription from RNA pol. II promoters
cytochrome c oxidase polypeptide VIb, putative
Similar to S. cerevisiae COX12; In S. cerevisiae: putative orthologue encodes a subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly
alanine-glyoxylate aminotransferase, putative
Similar to S. cerevisiae AGX1; In S. cerevisae: encodes an alanine:glyoxylate aminotransferase (AGT), catalysing the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; In C. albicans putative orthologue is an uncharacterized protein regulated by Gcn4p and hemoglobin
mitochondrial ABC iron-sulfur cluster transporter, putative
Similar to S. cerevisiae ATM1; In S. cerevisiae: encodes a mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
Similar to S. cerevisiae TMA108; In S. cerevisiae: encodes a protein that associates with ribosomes and is a putative metalloprotease; translation machinery associated protein, putative; zinc aminopeptidase, putative
appears to be a fusion of orf19.74 and orf19.75; Similar to S. cerevisiae SEC5; In S. cerevisiae: encodes a 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of secretory vesicles to active sites of exocytosis
2'-O-ribose RNA methyltransferase, putative
Similar to S. cerevisiae SBP1; In S. cerevisiae: encodes an AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants; AdoMet-dependent rRNA methyltransferase, putative; S-adenosyl-L-methionine-dependent methyltransferase, putative
In C. albicans: putative orthologue encodes ALS family protein; role in adhesion, biofilm formation, germ tube induction; expressed at infection of human buccal epithelial cells; putative GPI-anchor; induced by ketoconazole, low iron and at cell wall regeneration; regulated by Sfu1p; this orf (Cd36_65010) and Cd36_64800 have high similarity to CaALS2; however, whereas Cd36_65010 is similar in length to CaALS2, Cd36_64800 contains two large internal insertions of ca. 432aa and 612aa respectively.
retrotransposon:solo LTR, epsilon G, partial
retrovirus-related Pol polyprotein from transposon (fragment), putative
unidentified retrotransposon protein, putative
CipC-like antibiotic response protein, putative
predicted product has numerous significant matches to putative CipC proteins (reported as a major hyphal protein in Aspergillus fumigatus (Schwienbacher, M. Thesis (2005) Technische Universitaet Muenchen, Munich, Germany); none of these have been functionally characterised; Similar to Aspergillus fumigatus cipC
at N-terminal end, the predicted product has weak similarity to STE5, a pheromone-response scaffold protein in S. cerevisiae; Similar to C. albicans STE5; Similar to S. cerevisiae STE5
Similar to S. cerevisiae SPO71; In S. cerevisiae: putative orthologue is a meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; putative orthologue in S. pombe (mug56) is a meiotically upregulated gene
predicted product has numerous highly significant matches to predicted GTP-binding proteins/GTPases in fungi, plants, and animals, none of which has been functionally characterised; Similar to S. cerevisiae YLF2
RING-domain E3 ubiquitin ligase, putative
Similar to S. cerevisiae TUL1; In S. cerevisiae: putative orthologue encodes a Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality-control purposes
Similar to Homo sapiens AADAT; predicted product has numerous significant matches to uncharacterised fungal, plant, and animal proteins with sequence relationships to aminotransferases; putative human orthologue has sequence relationship to alpha-aminoadipate aminotransferase/kynurenine aminotransferases and shows such activity when expressed in E. coli (Goh et al.(2002). Mol. Genet. Metab. 76:172-180); putative orthologue in S. cerevisiae is a putative protein of unknown function; shares amino acid similarity with the aminotransferases Aro8p and Aro9p and is not an essential gene (Iraqui et al. (1998). Mol Gen Genet 257(2):238-48); kynurenine/alpha-aminoadipate aminotransferase mitochondrial precursor, putative
retrotransposon:solo LTR, tara C, truncated
uncharacterized protein YCL012C orthologue, putative
In C. albicans: putative orthologue is located on chromosome 7; has matches to several predicted fungal proteins (appears to be fungal specific), none of which has been functionally characterised; putative orthologue in S. cerevisiae is (YCL012C) is not an essential gene; possibly fungus-specific
In C. albicans: putative orthologue is a secreted lipase, member of a differentially expressed lipase gene family with possible roles in nutrition or in creating an acidic microenvironment; expressed more strongly during mucosal infections than during systemic infections
TATA binding protein-associated factor, putative
Similar to S. cerevisiae TAF2; In S. cerevisiae: TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation; transcription initiation factor TFIID subunit, putative
cytoplasmic isoleucine-tRNA synthetase, putative
Similar to S. cerevisiae ILS1; In S. cerevisiae: putative orthologue is a cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A; In C. albicans: putative orthologue is up-regulated along with other tRNA synthetases during early (30 mins to 3 h) infection of mice and is inhibited by Icofungipen
uncharacterized WD repeat-containing protein, putative
has several significant matches to predicted proteins containing WD repeat domains, but none has been functionally characterised; putative orthologue in S. cerevisae encodes protein of unknown function that is localised to the cytoplasm; null mutant is viable, but shows sensitivity to high (1 M) NaCl (Giaever et al. (2002). Nature 418(6896):387-91)
Similar to S. cerevisiae SUL1; significant matches to S. cerevisiae proteins; best match is to an uncharacterised putative sulfate permease (YPR003C) that physically interacts with Hsp82p, localizes to the ER, and is not an essential gene (Paulsen IT, et al. (1998). FEBS Lett 430(1-2):116-25); best match to a characterised protein is to SUL1, a high-affinity sulfate permease, which along with SUL2 controls the concentration of endogenous activated sulfate intermediates (Cherest et al. (1997). Genetics 145(3):627-35); sulphate transporter, putative
electron transfer flavoprotein complex subunit, mitochondrial precursor, putative
Similar to S. cerevisiae AIM45; In S. cerevisiae: protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with yeast frataxin Yfh1p; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
N-acetyl-glucosamine metabolism enzyme, putative
In C. albicans: encodes a protein required for wild-type mouse virulence and wild-type cycloheximide resistance; putative GTP-binding motif; in a gene cluster that encodes enzymes of GlcNAc catabolism
In C. albicans: putative orthologue encodes an N-acetylglucosamine (GlcNAc) kinase; involved in GlcNAc utilization; required for wild-type hyphal growth and mouse virulence; gene expression is GlcNAc-induced
glucosamine-6-phosphate deaminase, putative
In C. albicans: putative orthologue encodes a glucosamine-6-phosphate deaminase; enzyme of N-acetylglucosamine utilization; required for wild-type hyphal growth and mouse virulence; converts glucosamine 6-P to fructose 6-P; reaction is reversible in vitro; gene is GlcNAc-induced
N-acetylglucosamine-6-phosphate deacetylase, putative
In C. albicans: putative orthologue encodes a N-acetylglucosamine-6-phosphate (GlcNAcP) deacetylase; enzyme of N-acetylglucosamine utilization; required for wild-type hyphal growth and virulence in mouse systemic infection; gene is GlcNAc-induced
has significant sequence similarity to two adjacent C albicans ORFs (orf19.2158 and orf19.2160) and to cd36_65590; In C. albicans: encodes a putative transporter of the major facilitator superfamily (MFS); similar to Nag4p; required for wild-type mouse virulence and cycloheximide resistance; in gene cluster that includes genes encoding enzymes of GlcNAc catabolism; putative orthologues in S. cerevisiae (TPO3 and TPO2 gene) encode polyamine transport proteins specific for spermine that localize to the plasma membrane; member of the major facilitator superfamily; Similar to S. cerevisiae TPO3
has significant sequence similarity to two adjacent C albicans ORFs (orf19.2158 and orf19.2160) and to cd36_65570; In C. albicans: putative orthologue is a putative fungal-specific transporter similar to Nag3p; required for wild-type mouse virulence and wild-type cycloheximide resistance; gene cluster encodes enzymes of GlcNAc catabolism; putative orthologues in S. cerevisiae (TPO3 and TPO2 genes) encode polyamine transport proteins specific for spermine that localize to the plasma membrane; member of the major facilitator superfamily; Similar to S. cerevisiae TPO3
DNA damage checkpoint control protein, putative
Similar to S. cerevisiae RAD17; putative orthologue in C. albicans is located on chromosome 4 and has not been functionally characterised; In S. cerevisiae: encodes a DNA-damage checkpoint control protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints
retrotransposon:solo LTR, epsilon J (subtelomeric)
putative orthologue in C. albicans is located on chromosome R; gene product appears to be Candida specific; shows some limited sequence similarity with subtelomeric Y'-related helicases, e.g. C. albicans YRF1 (Q59KM5)