Candida dubliniensis CD36 chromosome 5, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992692.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
appears to be incomplete ORF; apparent frameshift; probable pseudogene; Similar to C. albicans YRF1 (HPR5)
retrotransposon Tca4 polyprotein, putative
retrotransposon:san A, partial Tcd4, LTR
retrotransposon Tca4 gag-like protein, putative
non-ltr retrotransposon zorro 3 orf1-related protein, putative
transposable element; Similar to C. albicans FGR13
mitochondrial 54S ribosomal protein MRPL1
subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, putative
Similar to S. cerevisiae GAA1; In S. cerevisiae: removes the GPI-anchoring signal and attaches GPI to proteins in the ER
In C. albicans: required for wild-type cell and hyphal morphology and for agar-invasive growth; required for full virulence and kidney tissue invasion in a mouse model of systemic infection, but not for kidney colonization or for immunogenicity
Similar to S. cerevisiae SEC28; In S. cerevisiae: regulates retrograde Golgi-to-ER protein traffic; epsilon-COP coatomer subunit, putative
threonyl-tRNA synthetase, cytoplasmic, putative
mitochondrial 54S ribosomal protein YmL38/YmL34
Similar to S. cerevisiae MRPL38; In S. cerevisiae: appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
uncharacterized integral membrane protein, putative
Similar to S. cerevisiae SRP1; In S. cerevisiae: mediates import of nuclear proteins; binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation; karyopherin subunit alpha, putative
Similar to S. cerevisiae VIP1; In S. cerevisiae: generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1; inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase, putative; inositol pyrophosphate synthase, putative
fatty acid synthase subunit beta (ec 2.3.1.86) [includes: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (ec 4.2.1.61); enoyl-[acyl-carrier-protein] reductase [nadh] (ec 1.3.1.9); [acyl-carrier-protein] acetyltransferase (ec 2.3.1.38); [acyl-carrier-protein] malonyltransferase (ec 2.3.1.39); s-acyl fatty acid synthase thioesterase (ec 3.1.2.14)]
catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH.
bromodomain-containing transcription factor, putative
Similar to S. cerevisiae BDF2; In S. cerevisiae: protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; protein involved in transcription initiation at TATA-containing promoters, putative
Similar to S. cerevisiae BRE1; In S. cerevisiae: E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79)
alpha-glucosidase II, catalytic subunit, putative
Similar to S. cerevisiae ROT2; In S. cerevisiae: required for normal cell wall synthesis
DNA replication structure-specific endonuclease subunit, putative
Similar to S. cerevisiae SLX1; In S. cerevisiae: subunit of a complex that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks
nuclear response regulator and transcription factor, putative
transcription factor Skn7 homologue, putative
belongs to the SRR1 family of proteins; SRR1 proteins are signalling proteins involved in regulating the circadian clock in Arabidopsis (see Pfam entry PF07985); signalling protein, putative
phosphoribosyl pyrophosphate synthetase, putative
Similar to S. cerevisiae PRS1; In S. cerevisiae: involved in nucleotide, histidine, and tryptophan biosynthesis; ribose-phosphate pyrophosphokinase, putative
Similar to S. cerevisiae NUC1; In S. cerevisiae: has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
Similar to S. cerevisiae SMC4; In S. cerevisiae: subunit of the condensin complex, which reorganizes chromosomes during cell division; structural maintenance of chromosomes protein, putative
DNA-directed RNA polymerase I subunit, putative
Similar to S. cerevisiae RPA14; In S. cerevisiae: one of the final two subunits of Saccharomyces cerevisiae RNA polymerase I and is proposed to play a role in the recruitment of pol I to the promoter
mitochondrial 54S ribosome protein domain-containing protein
Cold Sensitive for Fermentation protein 1 homologue, putative
Similar to S. cerevisiae CSF1; In S. cerevisiae: protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; low-temperature growth/nutrient uptake/fermentation effector, putative
Similar to S. cerevisiae XDJ1; In S. cerevisiae: involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
Similar to S. cerevisiae COF1; In S. cerevisiae: promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; spliced gene; cofilin, putative
uncharacterized protein Sgm1 homologue, putative
Similar to S. cerevisiae SGM1; In S. cerevisiae: required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
mitochondrial 37S ribosomal protein YmS16
adenosine-5' phosphosulphate kinase, putative
Similar to S. cerevisiae MET14; In S. cerevisiae: required for sulphate assimilation and involved in methionine metabolism; adenylyl-sulphate kinase, putative
class E vacuolar protein-sorting and endocytosis factor, putative
Similar to S. cerevisiae DID4; In S. cerevisiae: required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
Similar to Candida boidinii DAO1; spliced gene
iron transport multicopper oxidase precursor, putative
Similar to S. cerevisiae FET5; In S. cerevisiae: ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
Similar to S. cerevisiae KRE6; beta-glucan synthesis-associated protein, putative
phosphatidylinositol/phosphatidylcholine transfer protein, putative
In S. cerevisiae: phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs
GTPase activating factor, cell polarity/morphology, putative
Similar to S. cerevisiae BUD2; In S. cerevisiae: GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; GTPase activating protein involved in bud site selection, putative; bud site selection protein, putative
Similar to S. cerevisiae NAM7; In S. cerevisiae: ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance; atp-dependent helicase, SFI superfamily, putative
acid sphingomyelin phosphodiesterase, putative
Similar to Rattus norvegicus Smpdl3b; sphingomyelin phosphodiesterase precursor, putative
Similar to S. cerevisiae UBC13; In S. cerevisiae: involved in the error-free DNA postreplication repair pathway; ubiquitin-protein ligase, putative
aminophospholipid translocase (flippase), putative
Similar to S. cerevisiae DNF1; In S. cerevisiae: aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase; probable phospholipid-transporting ATPase, putative
Similar to S. cerevisiae LPF6; not a pseudogene in C. albicans
Similar to S. cerevisiae AAC2; In S. cerevisiae: exchanges cytosolic ADP for mitochondrially synthesized ATP
component of the KEOPS telomere regulatory complex
Similar to S. cerevisiae CGI121; In S. cerevisiae: involved in telomere uncapping and elongation as component of the KEOPS protein complex; also shown to be a component of the EKC protein complex; homolog of human CGI-121
Similar to S. cerevisiae EXO1; In S. cerevisiae: 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair
Similar to S. cerevisiae SAM50; sorting assembly machinery subunit, putative
Similar to S. cerevisiae THR1; In S. cerevisiae: required for threonine biosynthesis
helix-loop-helix DNA binding protein, putative
RNA polymerase II transcription factor B subunit, putative
Similar to S. cerevisiae TFB3; In S. cerevisiae: subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit; transcription initiation factor TFIIH subunit, putative
S-adenosylmethionine decarboxylase proenzyme, [contains: s-adenosylmethionine decarboxylase alpha chain; s adenosylmethionine decarboxylase beta chain], putative
Similar to S. cerevisiae SPE2; In S. cerevisiae: required for the biosynthesis of spermidine and spermine
[GPI-anchored] cell wall protein, HYR(-like) family member, putative
chromosome transmission fidelity protein, putative
Similar to S. cerevisiae CTF8; In S. cerevisiae: required for sister chromatid cohesion; kinetochore protein, putative; sister chromatid cohesion complex component, putative
putative uncharacterized protein ydl057w homologue, putative
Similar to S. cerevisiae SNF8; In S. cerevisiae: component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
Similar to S. cerevisiae PUS3; In S. cerevisiae: introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth
Similar to S. cerevisiae SPB4; In S. cerevisiae: nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; ribosomal biogenesis protein, putative
NEDD8-activating enzyme E1 regulatory subunit, putative
Similar to S. cerevisiae ULA1; ubiquitin-activating enzyme E1-like protein, putative
translation elongation factor 3 (EF-3), putative
In S. cerevisiae: stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex
meiosis-specific phospholipase, putative
Similar to S. cerevisiae SPO1; In S. cerevisiae: required for meiotic spindle pole body duplication and separation; required for spore formation; spliced gene
glutaredoxin-like protein precursor, putative
Similar to S. cerevisiae GRX6; thiol oxidoreductase, putative
Similar to S. cerevisiae RPS11B; spliced gene
small nuclear ribonucleoprotein, putative
Similar to S. cerevisiae SMD3; snRNP core protein, putative
zinc finger transcription factor, putative
Similar to S. cerevisiae FYV7; possibly fungal-specific; In S. cerevisiae: required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
vacuolar amino acid transporter, putative
Similar to S. cerevisiae AVT2; In S. cerevisiae: member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters
replication-pausing checkpoint complex subunit, putative
Similar to S. cerevisiae TOF1; In S. cerevisiae: subunit of a replication-pausing checkpoint complex that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; topoisomerase 1-associated factor, putative
Similar to S. cerevisiae PFA5; protein fatty acyltransferase, putative
RNA polymerase II-associated protein, putative
Similar to S. cerevisiae SNA2; spliced gene; uncharacterized transmembrane protein, putative
uncharacterized endoplasmic reticulum membrane protein precursor, putative
zinc cluster transcription factor, putative
Similar to S. cerevisiae SNM1; In S. cerevisiae: subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; cell cycle-regulated RNase, putative; pre-rRNA processing complex subunit, putative
ferric reductase and cupric reductase, putative
Similar to S. cerevisiae FRE2; ferric reductase transmembrane component precursor, putative; ferric-chelate reductase, putative
Similar to S. cerevisiae FRE4; ferric reductase transmembrane component precursor, putative; ferric-chelate reductase, putative
peroxisomal integral membrane protein, putative
NAD-dependent histone deacetylase, puytative
Similar to S. cerevisiae HST3; In S. cerevisiae: member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; known to play an important role in the regulation of transcriptional repression, microtubule organisation and DNA damage repair processes; member of the sirtuin (Sir2) protein family, putative; regulator of transcriptional repression
carbon catabolite derepressing protein kinase, putative
In S. cerevisiae: AMP-activated serine/threonine protein kinase required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; serine/threonine protein kinase, Snf/Sip transcriptional complex, putative
PWI domain mRNA processing protein, putative
pre-mRNA processing protein, putative; splicing co-activator, putative
uncharacterized YTH domain-containing protein, putative
Similar to S. cerevisiae CAT5; ubiquinone (Coenzyme Q) biosynthesis protein, putative
Similar to S. cerevisiae NUF2; In S. cerevisiae: component of the evolutionarily conserved kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
Similar to S. cerevisiae AZR1; In S. cerevisiae: involved in resistance to azole drugs such as ketoconazole and fluconazole; multi-drug-resistance transporter, putative; plasma membrane transporter of the major facilitator superfamily, putative
plasma membrane G-protein coupled receptor (GPCR), putative
regulates morphogenesis and hypha formation in Candida albicans
inositolphosphorylceramide synthase, putative
mutations confer aureobasidin A resistance; phosphatidylinositol:ceramide phosphoinositol transferase, putative
glucose-6-phosphate 1-epimerase, putative
hypothetical transposable element protein
Similar to S. cerevisiae VPS1; In S. cerevisiae: dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis; dynamin-like GTPase required for vacuolar protein sorting, putative; vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae POA1; In S. cerevisiae: phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
Similar to S. cerevisiae PUS4; In S. cerevisiae: atalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs
Similar to S. cerevisiae SHR5; In S. cerevisiae: adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; spliced gene; palmitoyltransferase subunit, putative
In S. cerevisiae: attaches heme to apo-cytochrome c in the mitochondrial intermembrane space; holocytochrome c synthase, putative
Similar to S. cerevisiae OTU2; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases, putative
Similar to S. cerevisiae GDS1; In S. cerevisiae: required for growth on glycerol as a carbon source; uncharacterized protein Gds1 homologue, putative
S-adenosyl-L-methionine (SAM)-dependent methyltransferase, putative
Similar to S. cerevisiae BUD23; In S. cerevisiae: involved in bud-site selection; bud site selection protein, putative; methyltransferase, putative
ribosomal protein, mitochondrial precursor, large subunit, putative
Similar to S. cerevisiae IMG1; In S. cerevisiae: required for both respiration and maintenance of the mitochondrial genome; spliced gene
N-terminal acetyltransferase C complex subunit, putative
Similar to S. cerevisiae MAK31; In S. cerevisiae: on-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
covalently-linked cell wall glycoprotein precursor, putative
Similar to S. cerevisiae CCW14; In S. cerevisiae: present in inner layer of the cell wall
RING finger domain-containing protein, putative
Similar to S. cerevisiae SLX8; In S. cerevisiae: possible role in sumoylation and in regulation of genome stability
uncharacterized zinc-finger protein, putative
HAP CCAAT-binding (Hap2/3/4/5) transcriptional modulator complex subunit, putative
Similar to S. cerevisiae HAP5; In S. cerevisiae: subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex; subunit of CCAAT-binding transcriptional modulator complex, putative; transcriptional activator, putative
Similar to S. cerevisiae DKA1; phosphatidylethanolamine-binding protein, protein kinase A signalling pathway, putative
pre-mRNA splicing U4/U6aU5 tri-snRNP complex subunit, putative
Similar to S. cerevisiae DIB1; spliceosome complex subunit, putative
Similar to S. cerevisiae TRX2; In S. cerevisiae: isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress
Similar to S. cerevisiae URA4; In S. cerevisiae: catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
glycerophosphoinositol permease, putative
Similar to S. cerevisiae GIT1; possibly fungal-specific; In S. cerevisiae: mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate
mitochondrial inner membrane protease subunit, putative
Similar to S. cerevisiae IMP2; In S. cerevisiae: required for maturation of mitochondrial proteins of the intermembrane space
mitochondrial intermembrane space cysteine motif protein, putative
WD-40 repeat domain-containing protein, putative
Similar to S. cerevisiae TEX1; In S. cerevisiae: component of the transcription export (TREX) complex; mRNA export protein, putative
COPII-coated vesicle complex subunit, putative
Similar to S. cerevisiae ERV46; In S. cerevisiae: localizes to COPII-coated vesicles; involved in the membrane fusion stage of transport; ER-derived vesicle protein, putative
mitochondrial 54S ribosomal protein YmL17/YmL30
cytochrome c peroxidase, mitochondrial precursor, putative
Similar to S. cerevisiae CCP1; In S. cerevisiae: degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
indoleamine 2,3-dioxygenase family protein, putative
Similar to S. cerevisiae BNA2; In S. cerevisiae: required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; tryptophan 2,3-dioxygenase, putative
Similar to S. cerevisiae NRD1; In S. cerevisiae: RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit, required for transcription termination and 3' end maturation of nonpolyadenylated RNAs; RNA-binding protein, putative
uncharacterized protein ynl254c homologue, putative
Similar to S. cerevisiae STI1; hsp90 co-chaperone, putative
AP-1-like transcription factor, putative
partially functionally complements the fluconazole sensitivity of an S. cerevisiae pdr1 pdr3 double mutant; basic leucine zipper (bZIP) transcription factor, putative; fluconazole resistance protein, putative
Similar to S. cerevisiae GAP1; general amino-acid permease, putative
no gene name yet assigned to C. dubliniensis gene; no positional orthologue on C. albicans chromosome 5; spliced gene; mating-type-like protein ALPHA2, putative
Similar to S. cerevisiae PIK1; In S. cerevisiae: catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton
no gene name yet assigned to C. dubliniensis gene; no positional orthologue on C. albicans chromosome 5; mating-type-like protein ALPHA1, putative
In S. cerevisiae: one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; polynucleotide adenylyltransferase, putative
endocytic membrane traffic recycling protein, putative
Similar to S. cerevisiae RCY1; In S. cerevisiae: involved in recycling plasma membrane proteins internalized by endocytosis; recyclin, putative
mitochondrial 54S ribosomal protein YmL36
subunit of the cytosolic chaperonin CCT ring complex, putative
Similar to S. cerevisiae CCT7; In S. cerevisiae: required for the assembly of actin and tubulins in vivo
In C. albicans: required for maintenance (not initiation) of hyphal growth
retrotransposon:solo LTR, moa C, truncated
Similar to S. cerevisiae MYO1; In S. cerevisiae: required for wild-type cytokinesis and cell separation
mitochondrial-processing peptidase (MPP) alpha subunit, mitochondrial precursor, putative
Similar to S. cerevisiae MAS2; In S. cerevisiae: essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
hyphally-regulated cell wall protein precursor, putative
this is more liklely to be HYR3 orthologue, since (a) it is the best BlastP hit on CGD web site, and (b) HYR3 is on C. albicans chromosome 5, whereas HYR1 is on chromosome 1
Similar to S. cerevisiae MSB3; In S. cerevisiae: regulates exocytosis via its action on Sec4p, also required for proper actin organization
folic acid synthesis protein, putative [includes: dihydroneopterin aldolase (ec 4.1.2.25); dihydro-6-hydroxymethylpterin-pyrophosphokinase (ec 2.7.6.3); dihydropteroate synthetase (ec 2.5.1.15)]
Similar to S. cerevisiae FOL1; In S. cerevisiae: multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
retrotransposon:solo LTR, episemon H, truncated
zinc finger-containing tanscription factor, putative
zinc finger-containing transcription factor, putative
N-terminal acetyltransferase complex subunit, putative
Similar to S. cerevisiae NAT1; In S. cerevisiae: N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; amino-terminal, alpha-amino, acetyltransferase, putative
Similar to S. cerevisiae SFT2; In S. cerevisiae: found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; protein transport protein, putative
Similar to S. cerevisiae NCE101; In S. cerevisiae: involved in secretion of proteins that lack classical secretory signal sequences
inositol polyphosphate-5-phosphatase, putative
Similar to S. cerevisiae INP54; inositol-1,4,5-trisphosphate 5-phosphatase, putative
Similar to S. cerevisiae PRP9; In S. cerevisiae: required for spliceosome assembly
Similar to S. cerevisiae RIB2; In S. cerevisiae: catalyzes the third step of the riboflavin biosynthesis pathway; cytoplasmic tRNA pseudouridine synthase involved in pseudouridylation of cytoplasmic tRNAs at position 32; pseudouridine synthase, putative
electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor, putative
GDP-GTP exchange factor for Cdc42p, putative
Similar to S. cerevisiae CDC24; guanine nucleotide exchange factor Cdc24 homologue, putative
Similar to S. cerevisiae ACH1; In S. cerevisiae: required for acetate utilization and for diploid pseudohyphal growth; acetyl-coa acylase, putative; acetyl-coa deacylase, putative
uncharacterized protein yor262w homologue, putative
Similar to S. cerevisiae COX10; In S. cerevisiae: catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders; protoheme IX farnesyltransferase, mitochondrial precursor, putative
cellular morphogenesis regulator, putative
Similar to S. cerevisiae DOP1; In S. cerevisiae: involved in establishing cellular polarity and morphogenesis; member of the Dopey family of cellular morphogenesis regulators; morphogenesis/filamentation protein, Dopey family, putative
Similar to S. cerevisiae ESF2; In S. cerevisiae: essential nucleolar protein involved in pre-18S rRNA processing; component of the small subunit (SSU) processome
glucose and lipid-regulated protein, putative
Similar to S. cerevisiae HSP12; heat shock protein, putative
Similar to S. cerevisiae RIX7; In S. cerevisiae: required for export of pre-ribosomal large subunits from the nucleus; ribosome biogenesis ATPase, putative; ribosome export protein, putative
putative pyridoxamine 5'-phosphate oxidase ylr456w (ec 1.4.3.5 (pnp/pmp oxidase ylr456w) (pnpox ylr456w)
pyridoxamine 5'-phosphate oxidase, putative
origin recognition complex subunit, putative
Similar to S. cerevisiae ORC4; In S. cerevisiae: directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
eukaryotic translation initiation factor 2 (eIF-2) subunit gamma, putative
Similar to S. cerevisiae GCD11; In S. cerevisiae: involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
Similar to S. cerevisiae LEU3; In S. cerevisiae: regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation
mitochondrial 37S ribosomal protein YMR31
Similar to S. cerevisiae YMR31; spliced gene
diadenosine 5',5'''-p1,p6-hexaphosphate hydrolase, putative
Similar to S. cerevisiae DDP1; In S. cerevisiae: member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates, required for efficient hydrolysis of diphosphorylated inositol polyphosphates; diadenosine and diphosphoinositol polyphosphate phosphohydrolase, putative
cAMP-independent regulatory protein, putative
Similar to S. pombe PAC2; In S. pombe: controls the onset of sexual development, by inhibiting the expression of ste11, in a pathway that is independent of the cAMP cascade
Similar to S. cerevisiae TAM41; In S. cerevisiae: involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex
Similar to S. cerevisiae THR4; In S. cerevisiae: conserved protein that catalyzes formation of threonine from 0-phosphohomoserine
3',5'-cyclic-nucleotide phosphodiesterase, putative
delta subunit of the coatomer complex, putative
Similar to S. cerevisiae RET2; In S. cerevisiae: coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
Similar to S. cerevisiae PER1; putatively involved in lipid remodelling of GPI-anchored proteins in the ER
pseudohyphal/invasive-growth/pheromone-pathways signal transduction serine/threonine-protein kinase, PAK (p21-activated kinase) family, putative
In S. cerevisiae: signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways; In C. albicans: protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; serine/threonine-protein kinase, putative
appears to be a fusion of orf19.4243 and orf19.4244; Similar to S. cerevisiae CUE2
mitochondrial protein, lipid/cell membrane biosynthesis, putative; phosphatidyl synthase, putative
Similar to S. cerevisiae DFM1; contains a DER1 domain (Pfam: PF04511); putative component of the ER proteolytic system involved with selectively degrading misfolded lumenal secretory proteins; ER-localized protease, putative
Similar to S. cerevisiae BUD32; In S. cerevisiae: protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex; bud site/morphogenesis serine/threonine-protein kinase, BUD family member, putative; serine/threonine-protein kinase, putative
uncharacterized GPI-anchored cell wall protein, putative
integrin alpha chain-like protein, putative
pre-mRNA polyadenylation factor, putative
Similar to S. cerevisiae FIP1; In S. cerevisiae: interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; subunit of cleavage polyadenylation factor (CPF), putative
eukaryotic translation initiation factor eIF-5, putative
Similar to S. cerevisiae TIF5; In S. cerevisiae: N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
apparent fusion of orf19.4262 and orf19.4263; Similar to S. cerevisiae PUF2; In S. cerevisiae: member of the PUF protein family; preferentially binds mRNAs encoding membrane-associated proteins
UDP-N-acetylglucosamine pyrophosphorylase, putative
In S. cerevisiae: catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
Similar to S. cerevisiae SPR28; spliced gene; sporulation-regulated protein, putative
U3 small nucleolar RNA-associated protein, putative
Similar to S. cerevisiae UTP13; In S. cerevisiae: component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; U3 snoRNA-associated protein, putative
Similar to S. cerevisiae MNT2; In S. cerevisiae: involved in adding the 4th and 5th mannose residues of O-linked glycans
sigma-like sequence protein, mitochondrial precursor, putative
Similar to S. cerevisiae SLS1; In S. cerevisiae: mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
proline oxidase, mitochondrial precursor, putative
Similar to S. cerevisiae PUT1; In S. cerevisiae: nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source
DNA repair protein Rad9 homologue, putative
Similar to S. cerevisiae RAD9; In S. cerevisiae: DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; In C. albicans: involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA damage checkpoint
negative regulator of transcription elongation, putative
Similar to S. cerevisiae MNT2; In S. cerevisiae: integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides
appears to be a fusion of orf19.4281 and orf19.4282
translation initiation factor eIF3 subunit, putative
Similar to S. cerevisiae BUR2; In S. cerevisiae: cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
Similar to S. cerevisiae XYL2; In S. cerevisiae: converts xylitol to D-xylulose in the endogenous xylose utilization pathway; xylitol dehydrogenase, putative
Similar to S. cerevisiae TRR1; In S. cerevisiae: cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
Similar to S. cerevisiae PEP12; In S. cerevisiae: target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; vacuolar protein sorting-associated protein, putative; vacuolar protein-targeting protein, putative
cytosolic iron-sulfur protein assembly protein, putative
Similar to S. cerevisiae CIA1; In S. cerevisiae: involved in assembly of cytosolic and nuclear iron-sulfur proteins
cytochrome c assembly flavoprotein, putative
Similar to S. cerevisiae CYC2; In S. cerevisiae: mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1; cytochrome c mitochondrial import factor, mitochondrial precursor, putative
histone transcription regulator, putative
Similar to S. cerevisiae HIR2; In S. cerevisiae: non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
beta' regulatory subunit of casein kinase 2, putative
Similar to S. cerevisiae CKB2; In S. cerevisiae: a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases; casein kinase II regulatory subunit, putative; casein kinase II subunit beta', putative
mitochondrial tryptophanyl-tRNA synthetase, putative
U6 snRNA-associated Sm-like protein, putative
Similar to S. cerevisiae LSM1; In S. cerevisiae: involved in degradation of cytoplasmic mRNAs; spliced gene
Similar to S. cerevisiae MDE1; In S. cerevisiae: acts in the methionine salvage pathway; methylthio-ribulose-1-phosphate dehydratase, putative
vacuolar protein-sorting-associated protein, putative
Similar to S. cerevisiae DID2; In S. cerevisiae: class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors; vacuolar-protein sorting and endocytosis factor, putative
serine/threonine protein kinase, bud growth and assembly of the septin ring, putative
Similar to S. cerevisiae HLS1; In S. cerevisiae: protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p; serine/threonine-protein kinase, putative
Similar to S. cerevisiae GRE2; induced by stress (osmotic, ionic, oxidative, heat shock and heavy metals) in S. cerevisiae; NADPH-dependent methylglyoxal reductase, putative
Similar to S. cerevisiae NDK1; In S. cerevisiae: catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
subunit of the SAGA transcriptional regulatory complex, putative
Similar to S. cerevisiae SPT8; In S. cerevisiae: subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters; transcription factor, putative
Similar to S. cerevisiae GYP8; In S. cerevisiae: GTPase-activating protein for yeast Rab family members; involved in the regulation of ER to Golgi vesicle transport
TauD/TfdA-family taurine catabolism dioxygenase, putative
Similar to S. cerevisiae FMP12; trimethyllysine dioxygenase, mitochondrial precursor, putative; uncharacterized oxidoreductase, putative
NAD(P)H-dependent D-xylose reductase I,II, putative
retrotransposon Tca2 polyprotein, putative
transcription factor, catabolite repression, putative
In C. albicans: regulates genes for utilization of carbon sources; In S. cerevisiae: transcription factor involved in glucose repression; transcriptional repressor, putative
Similar to S. cerevisiae YPT35; In S. cerevisiae: binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport; phosphoinositide-binding protein, putative; vesicular transport protein, putative
U4/U6.U5 small nuclear ribonucleoprotein component, putative
Similar to S. cerevisiae SNU66; In S. cerevisiae: component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; contains the SART-1 domain (Pfam:PF03343); SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing [1][2]. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae [3]. SART-1 is a known tumour antigen in a range of cancers recognised by T cells
Similar to S. cerevisiae CCC2; In S. cerevisiae: Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; copper-transporting ATPase, putative
hydroxyproline-rich glycoprotein, putative
Similar to Chlamydomonas reinhardtii GP1; vegetative cell wall protein precursor, putative
two inverted LTRs flanking remnants of ORFs and PBS
retrotransposon:iota W (truncated) and G, Tcd23, LTR
Tca3/gypsy-like retrotransposon relic, putative; transposable element
high-affinity nicotinic acid transporter, putative
Similar to S. cerevisiae TNA1; nicotinic acid permease, putative
transporter of the Major Facilitator Superfamily (MFS), putative
AAA ATPase involved in endosome to vacuole transport, putative
Similar to S. cerevisiae VPS4; In S. cerevisiae: required for efficient late endosome to vacuole transport; vacuolar protein sorting-associated protein, putative; vacuolar protein-targeting protein, putative
Similar to S. cerevisiae SMX3; spliced gene
Similar to S. cerevisiae GAB1; In S. cerevisiae: involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
Similar to S. cerevisiae SUT1; In S. cerevisiae: involved in induction of hypoxic gene expression; transcription factor of the Zn[II]2Cys6 family involved in sterol uptake, putative
Similar to S. cerevisiae SEC16; In S. cerevisiae: required for ER transport vesicle budding and autophagosome formation
serine/threonine-protein kinase, putative
Similar to S. cerevisiae PRR1; In S. cerevisiae: inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
subunit of the RNA polymerase II mediator complex, putative
Similar to S. cerevisiae RGR1; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
core RPS block consists of five complete RPS units of 2106bp each, plus one partial RPS unit of 1535bp; orientation = sense
RPS (RePeat Sequence) domain; last RPS unit is partial
Similar to S. cerevisiae BUB3; In S. cerevisiae: localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; kinetochore checkpoint WD40 repeat protein, putative
Similar to S. cerevisiae SET7; RMS1; lysine methyltransferase, putative
in-frame stop codons; frameshift; Similar to C. albicans LPF34
retrotransposon:solo LTR, kappa J, partial
retrotransposon:solo LTR, tara D, truncated
transient receptor potential (TRP) ion channel, putative
this class of proteins are essential for cellular viability and are involved in cell growth and cell wall synthesis; homologous to polycystic kidney disease related ion channel genes; no apparent orthologue in S. cerevisiae
Similar to S. cerevisiae RPN11; no apparent positional orthologue at this locus on C. albicans chromosome 5
elongation factor 1 gamma domain-containing protein
mitochondrial 37S ribosomal protein YmS-T
Similar to S. cerevisiae PCL1; In S. cerevisiae: Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth; cyclin, putative
fungus-specific zinc cluster transcription factor, putative
fungus-specific transcription factor, putative
component of the mitochondrial inner membrane electron transport chain, putative
Similar to S. cerevisiae QCR2; In S. cerevisiae: subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; subunit of the ubiquinol-cytochrome-c reductase complex, mitochondrial precursor, putative
RNA polymerase subunit common to RNA polymerases I, II, and III, putative
Similar to S. cerevisiae RPO26; In S. cerevisiae: RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
Similar to S. cerevisiae MLC2; regulatory light chain for the type II myosin, putative
Similar to S. cerevisiae ARP1; In S. cerevisiae: involved in cell polarization, endocytosis, and other cytoskeletal functions; centractin, putative
uracil phosphoribosyltransferase, putative
Similar to S. cerevisiae FUR1; In S. cerevisiae: synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
Similar to S. cerevisiae LSM7; spliced gene
ER protein involved in lipid remodelling of GPI-anchored proteins, putative
Similar to S. cerevisiae PER1; In S. cerevisiae: required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1; ER protein processing protein, putative
uncharacterized mitochondrial protein, putative
Similar to S. cerevisiae DUR3; In S. cerevisiae: plasma membrane transporter for both urea and polyamines; urea/polyamine transporter, putative
uncharacterized protein YNL144C, putative
coenzyme Q-binding protein, mitochondrial precursor, putative
Similar to S. cerevisiae COQ10; In S. cerevisiae: required for function of coenzyme Q in respiration by functioning in the delivery of Q6 to its proper location for electron transport
Similar to S. cerevisiae RPS25B; RPS25A; In S. cerevisiae: RPS25A and RPS25B are almost identical
Similar to S. cerevisiae NSP1; In S. cerevisiae: nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; nuclear pore protein, putative; nucleoporin, putative
histone deacetylase complex subunit, putative
Similar to S. cerevisiae SAP30; In S. cerevisiae: involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
coupling of ubiquitin conjugation to ER degradation protein, putative
Similar to S. cerevisiae CUE1; In S. cerevisiae: endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; ubiquitin-binding protein, putative
chromatin assembly complex subunit, putative
Similar to S. cerevisiae CAC2; In S. cerevisiae: component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans; chromatin assembly factor (CAF) subunit, putative
Similar to S. cerevisiae APE1; vacuolar aminopeptidase precursor, putative
DnaJ family chaperone protein, mitochondrial precursor, putative
Similar to S. cerevisiae MDJ1; In S. cerevisiae: involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones
In C. albicans: highly glycosylated enzyme that is secreted to the periplasm and to the culture medium; required for full virulence; may have role in scavenging for carbon or nitrogen; No apparent orthologue in S. cerevisiae; beta-N-acetylhexosaminidase, putative; beta-hexosaminidase precursor, putative
geranylgeranyl diphosphate synthase, putative
Similar to S. cerevisiae BTS1; In S. cerevisiae: increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic; geranylgeranyl pyrophosphate synthetase, putative; [includes: dimethylallyltranstransferase (ec 2.5.1.1) geranyltranstransferase (ec 2.5.1.10); farnesyltranstransferas (ec 2.5.1.29)]
diphthamide biosynthesis methyltransferase, putative
Similar to S. cerevisiae DPH5; In S. cerevisiae: methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); diphthine synthase, putative
class II aldolase/adducin domain protein, putative
phytanoyl-CoA dioxygenase family protein, putative
phytanoyl-CoA dioxygenase is a peroxisomal enzyme that catalyses the first step of phytanic acid alpha-oxidation
Similar to S. cerevisiae MTR10; In S. cerevisiae: mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; nuclear import/export receptor, putative
NAD(+)-dependent formate dehydrogenase, putative
Similar to S. cerevisiae FDH1; formate dehydrogenase, putative
Similar to S. cerevisiae GUK1; In S. cerevisiae: converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
contains hypoxia induced protein conserved region (Pfam:PF04588); spliced gene
Similar to S. cerevisiae BUD7; cargo-proteins export protein, ChAPs family member, putative; clathrin-coated vesicle protein, putative
subunit of TFIID and SAGA complexes, putative
Similar to S. cerevisiae TAF9; In S. cerevisiae: involved in RNA polymerase II transcription initiation and in chromatin modification; transcription initiation factor TFIID subunit, putative
Similar to S. cerevisiae THI80; In S. cerevisiae: phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
deoxyribonucleoside triphosphate pyrophosphohydrolase, putative
Similar to S. cerevisiae HAM1; In S. cerevisiae: mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis; the HAM1 protein protects the cell from HAP either on the level of deoxynucleoside triphosphate, or the DNA level by a yet unidentified set of reactions
uncharacterized protein ydl173w homologue, putative
regulator of sorbose utilization, putative
nucleolar protein, processome small subunit component, putative
Similar to S. cerevisiae FCF1; In S. cerevisiae: essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; rRNA-processing protein,putative; ribosome biogenesis protein, putative
calcineurin-like phosphoesterase, putative
Similar to S. cerevisiae DCR2; In S. cerevisiae: involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; metallo-phosphoesterase, putative; phosphatase, putative
transporter protein of the Major Facilitator Superfamily (MFS), putative
hydrophilin-like plasma membrane protein, putative
uncharacterised plasma membrane protein, putative
Jumonji-interacting protein 4 orthologue, putative
Similar to S. cerevisiae JIP4; uncharacterized protein
component of the high affinity calcium uptake system, putative
Similar to S. cerevisiae MID1; In S. cerevisiae: N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; stretch-activated cation channel precursor, putative
Similar to S. cerevisiae RFC3; In S. cerevisiae: DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; spliced gene; replication factor C (RF-C) subunit, putative
uncharacterized protein ypr091c homologue, putative
DNA-damage checkpoint kinase, ATR homologue, putative
Similar to S. cerevisiae MEC1; In S. cerevisiae: genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; mitosis entry checkpoint protein, putative; serine/threonine-protein kinase, putative
cyclin-dependent protein kinase regulatory subunit and adaptor, putative
Similar to S. cerevisiae CKS1; In S. cerevisiae: modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
eukaryotic translation initiation factor eIF-1, putative
Similar to S. cerevisiae SUI1; eIF-1 is a component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
Similar to S. cerevisiae CDS1; In S. cerevisiae: catalyzes the conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; CTP:phosphatidate cytidylyltransferase, putative
Similar to S. cerevisiae SCW11; In S. cerevisiae: may play a role in conjugation during mating based on its regulation by Ste12p; glycosyl hydrolase, putative; soluble cell wall protein, putative
In S. cerevisiae: required for cell separation after mitosis; endochitinase, putative
Similar to S. cerevisiae TLG1; In S. cerevisiae: mediates fusion of endosome-derived vesicles with the late Golgi; t-SNARE syntaxin protein, vesicular/late Golgi fusion, putative
COMPASS/SET1C histone methyltransferase complex subunit, putative
Similar to S. cerevisiae SDC1; In S. cerevisiae: subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
mitochondrial fusion machinery protein, putative
Similar to S. cerevisiae UGO1; In S. cerevisiae: Ugo1p binds directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion
pathogenesis/stress-related protein, thaumatin family member, putative; xenobiotic compound monooxygenase, DszA family, putative
ribonuclease T2-like precursor, putative
S-adenosyl-L-homocysteine hydrolase, putative
Similar to S. cerevisiae SAH1; In S. cerevisiae: catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine to an acceptor; adenosylhomocysteinase, putative
transcriptional activator of nitrogen-regulated genes, putative
Similar to S. cerevisiae GAT1; In S. cerevisiae: transcriptional activator of genes regulated by nitrogen catabolite repression; transcriptional activator, nitrogen catabolite repression, putative
eukaryotic translation initiation factor 4E (eIF-4E), putative
Similar to S. cerevisiae TIF45; In S. cerevisiae: the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G; mRNA cap-binding protein, putative
Similar to S. cerevisiae DUG1; glutamate carboxypeptidase-like protein, putative; metallopeptidase, putative; peptidase, M20 family member, putative
apparent genome rearrangement; in-frame stop codons; not a pseudogene in C. albicans
member of the protein disulfide-isomerase family, putative
Similar to S. cerevisiae MPD1; thioredoxin, putative
haloacid dehalogenase-like hydrolase, putative
Similar to S. cerevisiae SSM1; In S. cerevisiae: overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; pyrimidine nucleotidase, putative
Similar to S. cerevisiae AZF1; In S. cerevisiae: genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
involved in the redistribution of phospholipids after cell activation or injury (Pfam: PF03803)
ubiquitin carboxyl-terminal hydrolase, putative
Similar to S. cerevisiae YUH1; In S. cerevisiae: cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; spliced gene; ubiquitin thioesterase, putative
regulator of acetyl-co synthetase activity, putative
Similar to S. cerevisiae SFC1; In S. cerevisiae: transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization; succinate/fumarate mitochondrial transporter, putative
Similar to S. cerevisiae CAR1; In S. cerevisiae: responsible for arginine degradation; expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
glycerophosphocholine phosphodiesterase, putative
Similar to S. cerevisiae GDE1; In S. cerevisiae: hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; glycerophosphodiester phosphodiesterase, putative
negative regulator of the TOR signalling pathway, putative
Similar to S. cerevisiae TIP41; In S. cerevisiae: component of the TOR (target of rapamycin) signaling pathway, which controls nuclear localization of nutrient-regulated transcription factors; TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway; type 2A phosphatase activator, putative
mitochondrial 37S ribosomal protein RSM26
uncharacterized protein yjr088c homologue, putative
copper resistance-associated metallothionein, putative
In C. albicans: transcription is induced by copper
Similar to S. cerevisiae URA7; In S. cerevisiae: catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
component of the ESCRT-II complex, putative
Similar to S. cerevisiae VPS25; involved in ubiquitin-dependent sorting of proteins into the endosome; vacuolar protein-sorting-associated protein, putative
Similar to S. cerevisiae RPL43B; Rpl43Bp is described as being identical to Rpl43Ap; spliced gene
component of the SCF ubiquitin-ligase complex, putative
Similar to S. cerevisiae GRR1; In S. cerevisiae: involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
Cop9 signalosome complex subunit, putative
Similar to S. cerevisiae CSN12; In S. cerevisiae: equired for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
cytochrome c oxidase assembly protein, putative
Similar to S. cerevisiae COX18; In S. cerevisiae: has a role in the assembly of cytochrome c oxidase; required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; mitochondrial inner membrane protein, putative
RNA polymerase II elongation factor, putative
Similar to S. cerevisiae SPT4; In S. cerevisiae: forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing; transcription elongation factor, putative
Similar to S. cerevisiae YTA7; member of CDC48/PAS1/SEC18 family of ATPases, putative
mitochondrial methionyl-tRNA synthetase, putative
In S. cerevisiae: involved in mitochondrial protein synthesis
COPII transport vesicle biogenesis protein, putative
Similar to S. cerevisiae YIP1; In S. cerevisiae: integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; vesicle transport protein, putative
signal recognition particle (SRP) receptor subunit alpha, putative
Similar to S. cerevisiae SRP101; involved in SRP-dependent protein targetting
phosphatidylserine decarboxylase proenzyme precursor, putative [contains: phosphatidylserine decarboxylase beta chain; phosphatidylserine decarboxylase alpha chain]
Similar to S. cerevisiae PSD2; In S. cerevisiae: converts phosphatidylserine to phosphatidylethanolamine
methionyl-tRNA synthetase, cytoplasmic, putative
Similar to S. cerevisiae MES1; In S. cerevisiae: forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
glutamyl-tRNA(gln) amidotransferase subunit, mitochondrial precursor, putative
In S. cerevisiae: may be involved in aerobic respiration
Similar to S. cerevisiae FOL2; In S. cerevisiae: catalyzes the first step in the folic acid biosynthetic pathway
cell wall biogenesis protein phosphatase, putative
Similar to S. cerevisiae SSD1; Apparent disagreement about what this gene actually encodes; contains a Pfam hit corresponding to the catalytic domain of ribonuclease II, so those entries identifying the gene product as an exoribonuclease are probably correct; In S. cerevisiae: protein with an apparent role in maintenance of cellular integrity; interacts with components of the TOR pathway; exoribonuclease R, putative; exosomal 3'-5' exoribonuclease complex subunit, putative
DNA polymerase III (delta) small subunit, putative
subunit of the COMPASS (Set1C) histone methyltansferase complex, putative
Similar to S. cerevisiae BRE2; In S. cerevisiae: subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
Similar to S. cerevisiae NSE1; In S. cerevisiae: plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism; conserved in eukaryotes from yeast to human; subunit of the non-structural maintenance of chromosomes (SMC) complex, putative
cell wall glycosidase precursor, putative
Similar to S. cerevisiae CRH1; In S. cerevisiae: cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase; chitin transglycosidase, putative
6-phosphofructokinase subunit alpha, putative
retrotransposon:solo LTR, tara F, partial
heat shock factor (HSF)-type DNA-binding protein, putative
Similar to S. cerevisiae GOT1; In S. cerevisiae: evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events (Pfam: PF04178); spliced gene; Got1-like family Golgi transport protein, putative
uncharacterized protein ygr268c homologue, putative
Similar to S. cerevisiae HUA1; In S. cerevisiae: computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor, putative
Similar to S. cerevisiae PUT2; In S. cerevisiae: nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
subunit of the dynactin complex, putative
Similar to S. cerevisiae JNM1; In S. cerevisiae: required for proper nuclear migration and spindle partitioning during mitotic anaphase B
uncharacterized GTP-binding protein, putative
uncharacterized protein ygr272c homologue, putative
Similar to S. cerevisiae SLH1; In S. cerevisiae: involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; antiviral helicase, putative
Similar to S. cerevisiae MAL31; high-affinity maltose transporter, putative; maltose permease, putative; maltotriose transporter, putative
Similar to S. cerevisiae MAL2; alpha-glucosidase (maltase), putative
uncharacterized protein ygr266w homologue, putative
uncharacterized protein ygr237c homologue, putative
pyrimidine pathway regulatory protein, putative
Similar to S. cerevisiae PPR1; In S. cerevisiae: positively regulates transcription of genes involved in uracil biosynthesis; zinc finger-containing transcription factor, putative
DNA-directed RNA polymerase III subunit, putative
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit precursor, putative
Similar to S. cerevisiae OST3; In S. cerevisiae: gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; oligosaccharyl transferase gamma subunit, putative
calpain-like cysteine protease, putative
Similar to S. cerevisiae GPI10; In S. cerevisiae: integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog; alpha 1,2 mannosyltransferase, putative; glycosylphosphatidylinositol-anchor biosynthesis protein, putative
Similar to S. cerevisiae ADH1; In C. albicans: at surface of yeast-form cells but not hyphae; soluble in hyphae; immunogenic in human or mouse
uncharacterized protein yml020w, putative
Similar to S. cerevisiae PHO2; In S. cerevisiae: homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism
mitochondrial inner membrane protein, putative
Similar to S. cerevisiae MSS2; In S. cerevisiae: peripherally bound inner membrane protein of the mitochondrial matrix, binds to the Cox2p C-terminal tail to facilitate its translocation through the inner membrane
DNA damage response protein kinase, putative
Similar to S. cerevisiae DUN1; In S. cerevisiae: cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair; spliced gene; cell-cycle checkpoint serine-threonine kinase, putative
Similar to S. cerevisiae TIP20; In S. cerevisiae: peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane
T-complex protein 1 subunit gamma, putative
Similar to S. cerevisiae CCT3; cytosolic chaperonin complex subunit, putative; subunit of the cytosolic chaperonin Cct ring complex, actin and tubulin assembly, putative
In S. cerevisiae: catalyzes the final step in Coenzyme A biosynthesis
Similar to S. cerevisiae PAN5; part of the pantothenic acid pathway; ketopantoate reductase, putative
ribosomal N-lysine methyltransferase, putative
Ca++/calmodulin-regulated type 2B protein phosphatase, putative
Similar to S. cerevisiae CNB1; calcineurin regulatory subunit, putative; calcineurin subunit B, putative; protein phosphatase 2B regulatory subunit, putative
Similar to S. cerevisiae PAN3; In S. cerevisiae: acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; poly(A)-specific ribonuclease subunit, putative
Similar to S. cerevisiae PCL5; cyclin, putative; phosphate system cyclin, putative
putative uncharacterized protein yhr045w homologue, putative
Similar to S. cerevisiae CDC1; In S. cerevisiae: putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution; cell division control protein, putative
Similar to S. cerevisiae CAG1; In S. cerevisiae: GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; guanine nucleotide-binding protein subunit alpha, putative; pheromone pathway heterotrimeric G protein GTP-binding alpha subunit, putative
core subunit of the ubiquinol-cytochrome-c reductase complex, mitochondrial precursor, putative
Similar to S. cerevisiae COR1; In S. cerevisiae: component of the mitochondrial inner membrane electron transport chain
mitochondrial 37S ribosomal protein RSM7
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor, putative
Similar to S. cerevisiae SDH4; In S. cerevisiae: couples the oxidation of succinate to the transfer of electrons to ubiquinone; succinate-ubiquinone reductase membrane anchor subunit, putative
mitochondrial 37S ribosomal protein MRP2
riboflavin synthase alpha chain, putative
Similar to S. cerevisiae RIB5; In S. cerevisiae: catalyzes the last step of the riboflavin biosynthesis pathway
In S. cerevisiae: catalyzes the first step in histidine biosynthesis
Similar to S. cerevisiae RER2; In S. cerevisiae: cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; dehydrodolichyl diphosphate synthetase, putative
Similar to S. cerevisiae PRI1; In S. cerevisiae: required for DNA synthesis and double-strand break repair; subunit of the DNA polymerase alpha:primase complex, putative
RNA-dependent ATPase/ATP-dependent RNA helicase, putative
Similar to S. cerevisiae PRP22; In S. cerevisiae: associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Similar to S. cerevisiae RPN5; proteasome regulatory subunit, putative
1,3-beta-glucanosyltransferase, putative
Similar to S. cerevisiae GAS5; cell wall 1,3-beta-glucanosyltransferase, putative; glycolipid-anchored surface protein precursor, putative
retrotransposon:solo LTR, pi F, truncated
Mu1-like medium subunit of the clathrin-associated protein complex (AP-1), putative
Similar to S. cerevisiae APM1; In S. cerevisiae: binds clathrin; involved in clathrin-dependent Golgi protein sorting; clathrin associated protein complex medium subunit, putative
Similar to S. cerevisiae ILV3; In S. cerevisiae: catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; dihydroxy-acid dehydratase, mitochondrial precursor, putative
Similar to S. cerevisiae PEX4; In S. cerevisiae: peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis; peroxisomal ubiquitin-conjugating enzyme, putative; ubiquitin protein ligase, putative
subunit of the RNA polymerase II holoenzyme, putative
Similar to S. cerevisiae ASK10; In S. cerevisiae: phosphorylated in response to oxidative stress
muddled meiosis protein 2 homologue, putative
Similar to S. cerevisiae MUM2; In S. cerevisiae: cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
dihydroceramide delta 4-desaturase, putative
Similar to S. pombe DSD1; fatty acid desaturase, putative; sphingolipid delta 4-desaturase, putative
Similar to S. cerevisiae HTS1; In S. cerevisiae: cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; histidyl-tRNA synthetase, mitochondrial precursor, putative
Tcd21-like Gag ORF sections (subtelomeric)
retrotransposon:solo LTR, iota D (subtelomeric)
Y'element ATP-dependent helicase, putative