Candida dubliniensis CD36 chromosome 4, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992691.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
Similar to C. albicans YRF1, (HPR5); partial sequence, appears to be a pseudogene
retrotransposon-related protein, putative
Similar to S. cerevisiae NHA1; In S. cerevisiae: Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
cation transport regulator-like protein, putative
transferrin receptor-like protein, putative
Similar to S. cerevisiae TRE1; In S. cerevisiae: plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors; uncharacterized protein Tre1 homologue, putative
1,4-butanediol diacrylate esterase, putative
Similar to C. albicans BDA1; beta-lactamase family protein, putative; transesterase, putative
1,3-beta-glucanosyltransferase, putative
Similar to S. cerevisiae GAS4; In S. cerevisiae: involved in spore wall assembly; spliced gene; glycolipid-anchored surface protein precursor, putative
ferric reductase transmembrane component precursor, putative
Similar to S. cerevisiae FRE5; ferric-chelate reductase, putative
Similar to C. albicans CRW3; glycosyl-phosphatidylinositol protein, putative; hyphal surface antigen precursor, putative
Similar to C. albicans RBT5; cell wall protein, putative; glycosyl-phosphatidylinositol protein
Similar to S. cerevisiae MEP2; In C. albicans: ammonium permease and regulator of nitrogen starvation-induced filamentation; Biswas K and Morschhauser J (2005) The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans. Mol Microbiol 56(3):649-69; ammonium transporter, putative
histidine biosynthesis trifunctional protein [includes: phosphoribosyl-amp cyclohydrolase (ec 3.5.4.19); phosphoribosyl-atp pyrophosphohydrolase (ec 3.6.1.31); histidinol dehydrogenase (ec 1.1.1.23) (hdh)], putative
histidinol dehydrogenase, putative; phosphoribosyl-AMP cyclohydrolase, putative; phosphoribosyl-ATP pyrophosphohydrolase, putative
Similar to S. cerevisiae PEX5; peroxisomal targeting signal receptor, putative
Similar to S. cerevisiae CAR2; ornithine aminotransferase, putative; ornithine-oxo-acid aminotransferase, putative
o-acetylhomoserine o-acetylserine sulphydrylase, putative
Similar to S. cerevisiae SUB2; spliced gene
delta 1-pyrroline-5-carboxylate reductase, putative
Similar to S. cerevisiae PRO3; pyrroline-5-carboxylate reductase, putative
JmjC domain-containing histone demethylase, putative
ATP synthase subunit beta, mitochondrial precursor, putative
Similar to S. cerevisiae ATP2; spliced gene; F1F0 ATP synthase beta subunit, putative
Similar to S. cerevisiae STE24; spliced gene; zinc metalloprotease, putative
Rieske [2Fe-2S] domain protein, putative
spliced gene; choline monooxygenase, putative; iron-sulfur cluster-binding protein, putative; phenylpropionate dioxygenase, putative
subunit of the SWI/SNF chromatin remodeling complex, putative
Similar to S. cerevisiae MNN10; possibly fungus-specific; galactosyltransferase, putative
C3HC4 zinc-binding integral peroxisomal membrane protein peroxin, putative
Similar to S. cerevisiae PEX10; spliced gene; RING finger peroxisomal membrane peroxin, putative; peroxisome assembly protein, putative
ATP synthase E chain, mitochondrial, putative
Similar to S. cerevisiae TIM11 (ATP21); subunit E of mitochondrial F1F0-ATPase, putative; translocase of the inner membrane, putative
mitochondrial protein phosphatase type 2C, putative
Similar to S. cerevisiae PEP7; In S. cerevisiae: multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance; vesicle transport protein, putative
Similar to S. pombe CDC15; Similar to S. cerevisiae MAD1; septation protein, putative; spindle assembly checkpoint component, putative
NAD(+)-specific d-arabinose dehydrogenase, putative
Similar to S. cerevisiae ARA2; d-arabinose 1-dehydrogenase, putative
RNA polymerase II transcriptional coactivator, putative
Similar to S. cerevisiae MNR2; possibly fungus-specific; magnesium transporter, putative; manganese resistance protein, putative
endoplasmic reticulum transmembrane protein, putative
regulator of actin cytoskeleton, putative
Similar to S. cerevisiae SYP1; In S. cerevisiae: potential role in actin cytoskeletal organization
Similar to S. cerevisiae MEP2; ammonium transporter, putative
GPI-anchored cell wall protein, putative
Similar to S. cerevisiae FIT1; contains eight-cysteine CFEM domain - proteins containing this domain are postulated to play a key role in formation, development and/or maintenance of the biofilm structure in C. albicans; Perez et al. 2006. FEMS Yeast Res. 6: 1074-1084. Has independently been identified as a cell-surface mannosylated protein involved in haemin and haemoglobin-iron utilization (Weissman and Kornitzer. 2004; membrane protein involved in heme-iron utilization, putative; protein involved in biofilm development, putative
Similar to S. cerevisiae RIS1; putative member of the SWI/SNF family of DNA-dependent ATPases
DNA-3-methyladenine glycosidase II, putative
Similar to S. cerevisiae MAG2; In S. cerevisiae: catalyzes of the hydrolysis of alkylated DNA
plasma membrane urea transporter, putative
Similar to S. cerevisiae DUR3; possibly fungus-specific; polyamine tansporter, putative; urea transporter/permease, putative
diphthamide biosynthesis protein, putative
J-protein constituent of the mitochondrial import motor associated with the presequence translocase, putative
Similar to S. cerevisiae PAM18; co-chaperone, putative; mitochondrial import inner membrane translocase subunit, putative
Similar to S. cerevisiae NMD5; karyopherin (carrier protein involved in nuclear import of proteins), putative; nonsense-mediated mRNA decay protein, putative
mitochondrial outer membrane protein, putative
Similar to S. cerevisiae MMM1; In S. cerevisiae: involved in import and assembly of outer membrane beta-barrel proteins
CTP:phosphocholine cytidylyltransferase, putative
Similar to S. cerevisiae PCT1; In S. cerevisiae: rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis; cholinephosphate cytidylyltransferase, putative
Similar to S. pombe IBP1; In S. pombe: may play a role in DNA replication checkpoint via regulation of hsk1 or may act downstream of hsk1 in an S-phase regulatory pathway; dual specificity phosphatase, putative; itsy bitsy phosphatase, putative
uncharacterized oxidoreductase, putative
signal peptidase complex subunit, putative
Similar to S. cerevisiae SPC2; In C. albicans: SPC2 is induced in filamentous growth - Kadosh D and Johnson AD (2005) Induction of the Candida albicans Filamentous Growth Program by Relief of Transcriptional Repression: A Genome-wide Analysis. Mol Biol Cell 16(6):2903-12
subunit of the secretory polypeptide translocation complex, putative
conserved hypothetical protein; possibly Candida-specific
histidinol-phosphate aminotransferase, putative
In S. cerevisiae: catalyzes the seventh step in histidine biosynthesis; imidazole acetol-phosphate transaminase, putative
mitochondrial 37S ribosomal protein MRPS17
outward-rectifier potassium channel, putative
In C. albicans: outwardly rectifying, noisily gated potassium channel; modulates sensitivity to human salivary histatin (Hst5) - Baev D, et al. (2003) Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. Infect Immun 71(6):3251-60
Similar to S. cerevisiae DPH2; In S. cerevisiae: required for synthesis of diphthamide, a modified histidine residue of translation elongation factor 2
Similar to S. cerevisiae PHO13; In S. cerevisiae: alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
conserved hypothetical protein; possibly fungus-specific
O-glycosylated covalently-bound cell wall protein, putative
subunit of ribonucleases P/MRP, putative
Similar to S. cerevisiae POP7; In S. cerevisiae: subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
uncharacterized protein YPL108W homologue, putative
uncharacterized zinc finger-containing protein, putative
translation machinery-associated protein, putative
Similar to S. cerevisiae MLH1; In S. cerevisiae: required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; human homolog is associated with hereditary non-polyposis colon cancer
non-structural maintenance of chromosome element, putative
Similar to S. cerevisiae NSE4 (QRI2); subunit of DNA repair complex, putative
transporter of the mitochondrial inner membrane, putative
peroxisomal-2,4-dienoyl-CoA reductase, putative
sphingomyelin phosphodiesterase precursor, putative
Similar to C. elegans asm-2; Similar to C. albicans ASM1
Similar to S. cerevisiae PIN2; In C. albicans: expression increases in the absence of adenlyl cyclase - Harcus D, et al. (2004) Transcription profiling of cyclic AMP signaling in Candida albicans. Mol Biol Cell 15(10):4490-9; In S. cerevisiae: induces appearance of [PIN+] prion when overproduced; possibly fungus-specific
tRNA nucleotidyltransferase, mitochondrial precursor, putative
pentafunctional AROM polypeptide, putative
Similar to S. cerevisiae ARO1; In S. cerevisiae: catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; possibly fungus-specific
Similar to S. cerevisiae ELP6; possibly fungus-specific
internally-deleted and rearranged element
retrotransposon:kotuku H and J,Tcd32, LTR
dynein-related AAA-type ATPase, putative
Similar to S. cerevisiae MDN1; In S. cerevisiae: forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm; midasin, putative
divalent metal ion transporter, putative
Similar to S. cerevisiae SMF1; manganese transporter, putative
similarities in Fasta hits probably biased by high serine residue content
ribosomal protein, large subunit, putative
Similar to S. cerevisiae RPL40B (UBI2, UB12); Similar to S. cerevisiae RPL40A (UBI1, UB11); S. cerevisiae RPL40A and B are identical
Similar to S. cerevisiae MLP1; In S. cerevisiae: myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
Similar to S. cerevisiae RAT1; In S. cerevisiae: nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination; In C. albicans: 5'-->3' exoribonuclease; similar to S. cerevisiae nuclear exoribonuclease Rat1p; suppresses S. cerevisiae kem1 mutant slow growth, mating defect, and haploid invasive growth defect - An HS, et al. (2004) Identification of an exoribonuclease homolog, CaKEM1/CaXRN1, in Candida albicans and its characterization in filamentous growth. FEMS Microbiol Lett 235(2):297-303
nucleosome-binding component of the SWR1 complex, putative
Similar to S. cerevisiae VPS71; possibly fungus-specific; appears to be some confusion over exactly what this protein does - see SGD entry; In S. cerevisiae: nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting; vacuolar protein sorting-associated protein, putative
mitochondrial distribution and morphology protein, putative
Similar to S. cerevisiae MDM35; length of the C. dubliniensis orthologue (89 aa) is similar to those in P. stipitis (89 aa), D. hansenii (95 aa) and yeast (86 aa). C. albicans annotated orthologue has extended 5' end encoding protein of 180 aa
copper resistance determinant protein, putative
two inverted LTRs flanking internal region
retrotransposon:iota Q and T, Tcd23, LTR
zinc finger DNA-binding transcription factor, putative
protein required for wild-type susceptibiliy to caspofungin and cell wall damage response
cytoplasmic aspartate aminotransferase, putative
retrotransposon:solo LTR, beta D, partial
retrotransposon:solo LTR, beta F, truncated
retrotransposon:solo LTR, beta E, partial
retrotransposon:solo LTR, toroa B, truncated
cell wall protein with similarity to glucanases, putative
Similar to S. cerevisiae SCW10; In S. cerevisiae: cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; glucan 1,3-beta-glucosidase, putative
histone-specific N-acetyltransferase, putative
Similar to S. cerevisiae NAT4; In S. cerevisiae: N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
Similar to S. cerevisiae RLM1; In S. cerevisiae: transcription factor involved in activation of genes involved in cell wall integrity
Similar to S. cerevisiae RPS6A/RPS6B; spliced gene
Similar to S. cerevisiae PRP21; In S. cerevisiae: involved in the early stages of spliceosome assembly
RING finger and CHY zinc finger domain-containing protein, putative
homology to human PIRH2 (p53-induced RING-H2 protein) which encodes a ubiquitin-protein ligase; Similar to Homo sapiens RCHY1 (PIRH2)
nuclear envelope morphology protein, putative
Similar to S. cerevisiae NEM1; In S. cerevisiae: protein required for formation of a spherical nucleus and meiotic division
oligopeptide transporter protein, putative
member of fungal specific oligopeptide transporter family
possibly Candida-specific; orf19.12121 has been deleted from CGD due to presence of a frameshift
hypothetical GPI-anchored protein, conserved
regulatory subunit of acetolacetate synthase, putative
Similar to S. cerevisiae ILV6; In S. cerevisiae: required for first step of branched chain amino acid biosynthesis, yeast mutants require isoLeucine plus valine (hence name ILV6 -IsoLeucine plus Valine requiring)
transcription factor with zinc cluster DNA-binding motif, putative
identified as an essential putative transcription factor in a screen of putative transcription factor mutants: Nobile & Mitchell (2005) Curr Biol. 15(12):1150-1155
Similar to S. cerevisiae HAP3; spliced gene; In S. cerevisiae: subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression
Similar to S. cerevisiae BEM1; In C. albicans: required for wild-type budding, hyphal growth, and virulence; In S. cerevisiae: involved in establishing cell polarity and morphogenesis
glycylpeptide N-tetradecanoyltransferase, putative
essential protein required for attachement of the fatty acid myristate to a small number of proteins at an N-terminal gly; potential antifungal target; myristoyl-CoA:protein N-myristoyltransferase, putative
periodic tryptophan (W) protein, putative
Similar to S. cerevisiae PWP1; In S. cerevisiae: protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; rRNA processing protein, putative
Similar to S. cerevisiae HRT3; HRT stands for: High level expression Reduces Ty3 transposition
subunit of eukaryotic translation initiation factor 3 (eIF3), putative
Similar to S. cerevisiae NIP1; In S. cerevisiae: involved in the assembly of preinitiation complex and start codon selection
uncharacterized protein YGL211W homologue, putative
Similar to S. cerevisiae NCS6; In S. cerevisiae: required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth
NADP(+)-dependent dehydrogenase, putative
In S. cerevisiae: NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; Similar to S. cerevisiae TMA29; translational machinery associated oxidoreductase protein, putative
Similar to S. cerevisiae RPL20A/RPL20B; RPL20A and RPL20B are nearly identical in S. cerevisiae
Similar to S. cerevisiae ERG25; In S. cerevisiae: catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
arginine-specific carbamoyl-phosphate synthetase, small chain, putative
Similar to S. cerevisiae CPA1; In S. cerevisiae: catalyzes a step in the synthesis of citrulline, an arginine precursor; carbamoyl-phosphate synthase, small chain, putative; glutamine amidotransferase, putative
ubiquitin ligase-binding protein, putatuve
subunit of CPF (cleavage and polyadenylation factor), putative
Similar to S. cerevisiae MPE1; In S. cerevisiae: plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA
subunit of the nuclear pore complex (NPC), putaitve
Similar to S. cerevisiae NUP120; In S. cerevisiae: required for even distribution of NPCs around the nuclear envelope
TOR signalling pathway regulator, putative
Similar to S. cerevisiae TAP42; In S. cerevisiae: negative regulator of the TOR signalling pathway; type 2A phosphatase-associated protein, putative
transcription initiation factor IIA (TFIIA) small subunit, putative
uncharacterised protein YMR027W homologue, putative
high-mobility group non-histone chromosomal protein, putative
Similar to S. cerevisiae PBY1; In S. cerevisiae: putative tubulin tyrosine ligase associated with P-bodies
mitochondrial import inner membrane translocase subunit, putative
Similar to S. cerevisiae MRS5; In S. cerevisiae: essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
fructose-1,6-bisphosphate aldolase, putative
Similar to S. cerevisiae FBA1; In S. cerevisiae: required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
N-acetyltransferase catalytic subunit, putative
proliferating cell nuclear antigen (PCNA), putative
Similar to S. cerevisiae POL30; In S. cerevisiae: functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
Similar to S. cerevisiae ATG11; In S. cerevisiae: peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy); sequence similarity with experimentally-verified autophagy-related protein is weak - possible transitive annotation errors
phosphoribosyl pyrophosphate synthetase, putative
Similar to S. cerevisiae PRS2; In S. cerevisiae: involved in nucleotide, histidine, and tryptophan biosynthesis; ribose-phosphate pyrophosphokinase, putative
pyruvate decarboxylase isozyme, putative
Similar to S. cerevisiae PDC1; spliced gene
Similar to S. cerevisiae ERG8; In S. cerevisiae: an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
Similar to S. cerevisiae TYR1; In S. cerevisiae: involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
ADP-ribosylation factor-like protein, putative
Similar to S. cerevisiae ARL1; In S. cerevisiae: soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; Arf-like GTPase, putative
malate dehydrogenase, mitochondrial precursor, putative
Similar to S. cerevisiae MDH1; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle
Similar to S. cerevisiae TFC1; In S. cerevisiae: one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; subunit of the RNA polymerase III transcription initiator factor complex, putative; transcription factor Tau subunit, putative
dolichol-phosphate mannosyltransferase subunit, putative
Similar to Magnoporthe grisea MGG_10055; Similar to Homo sapiens DPM3
Similar to S. cerevisiae PHO89; up-regulated in opaque phase cells - Lan CY, et al. (2002) Metabolic specialization associated with phenotypic switching in Candida albicans. Proc Natl Acad Sci U S A 99(23):14907-12; up-regulated in biofilms - Murillo LA, et al. (2005) Genome-Wide Transcription Profiling of the Early Phase of Biofilm Formation by Candida albicans. Eukaryot Cell 4(9):1562-73; phosphate permease PHO89, putative
F-actin-capping protein subunit beta, putative
Similar to S. cerevisiae CAP2; In S. cerevisiae: beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization
Similar to S. cerevisiae CLC1; In S. cerevisiae: subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
GTPase-activating protein (GAP) for Rho-type GTPase Cdc42p, putative
In S. cerevisiae: GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; In C. albicans: involved in cell signaling pathways that control cell polarity; phosphorylation of Rga2p by CDK/Hgc1 is crucial for hyphal growth; Rho-type GTPase-activating protein, putative
UDP-glucose ceramide glucosyltransferase
Similar to Pneumocystis carinii PCGCS1; ceramide glucosyltransferase, putative
carnitine O-acetyltransferase, mitochondrial precursor, putative
In S. cerevisiae: present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes; carnitine acetylase, putative; ceramide glucosyltransferase, putative
Similar to S. cerevisiae FMS1; In S. cerevisiae: polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; corticosteroid-binding protein, putative; flavin-containing amine oxidoreductase, putative; polyamine oxidase, putative
subunit of TFIIF (transcription factor II), putative
Similar to S. cerevisiae TFG1; In S. cerevisiae: involved in both transcription initiation and elongation of RNA polymerase II; transcription initiation factor IIF subunit alpha, putative
carnitine/acylcarnitine carrier protein, putative
Similar to S. cerevisiae YMC2; In S. cerevisiae: mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; inner membrane transporter, mitochondrial precursor, putative
3'-to-5' phosphorolytic exoribonuclease, putative
Similar to S. cerevisiae SKI6; In S. cerevisiae: 3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; exosome complex exonuclease, putative; ribosomal RNA processing protein, putative
Similar to S. cerevisiae GPI14; In S. cerevisiae: involved in GPI anchor biosynthesis; glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase, putative
Similar to S. cerevisiae ERV29; In S. cerevisiae: protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
Similar to S. cerevisiae CYT2; transcript regulated by NRG1 - Murad AM, et al. (2001). Mol Microbiol 42(4):981-93; In S. cerevisiae: involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
subunit of guanine nucleotide-binding protein, putative
ABC1 family protein, mitochondrial precursor, putative
In C. albicans: involved in degradation of aromatic compounds
Similar to S. cerevisiae BGL2; In S. cerevisiae: major protein of the cell wall, involved in cell wall maintenance; glucan 1,3-beta-glucosidase precursor, putative
Similar to S. cerevisiae BFR1; In S. cerevisiae: component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), putative
Similar to S. cerevisiae IDI1; In S. cerevisiae: catalyzes an essential activation step in the isoprenoid biosynthetic pathway; isopentenyl-diphosphate delta-isomerase, putative
lipoic acid synthetase, mitochondrial precursor, putative
Similar to S. cerevisiae LIP5; In S. cerevisiae: protein involved in biosynthesis of the coenzyme lipoic acid
In C. albicans: associated with phenotypic switching - Srikantha T, et al. (2001) The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans. J Bacteriol 183(15):4614-25; Similar to S. cerevisiae HOS3
Rho GTPase-activating protein (RhoGAP), putative
In C. albicans: possibly involved in morphogenesis - Court H and Sudbery P (2007) Regulation of Cdc42 GTPase Activity in the Formation of Hyphae in Candida albicans. Mol Biol Cell 18(1):265-81; In S. cerevisiae: involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly; Similar to S. cerevisiae BEM3; bud emergence protein, putative
Similar to S. cerevisiae SOD1; spliced gene; superoxide dismutase, putative
Similar to S. cerevisiae PBI2; In S. cerevisiae: cytosolic inhibitor of vacuolar proteinase B, required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
In C. albicans: AMS1 is regulated by NRG1 - Murad AM, et al. (2001) Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1. Mol Microbiol 42(4):981-93; Similar to S. cerevisiae AMS1; In S. cerevisiae: vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
Similar to S. cerevisiae CCW12; covalently-linked cell wall protein precursor, putative
Similar to S. cerevisiae AHP1; In S. cerevisiae: reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; thiol-specific peroxiredoxin, putative
glycosylphosphatidylinositol anchor biosynthesis protein, putative
Similar to S. cerevisiae GPI11; In S. cerevisiae: ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate
subunit of the mRNA cleavage and polyadenylation factor, putative
Similar to S. cerevisiae CFT1; In S. cerevisiae: RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation
Similar to S. cerevisiae MUC1; mucin-like protein, putative
ER lumen protein retaining receptor (HDEL receptor), putative
Similar to S. cerevisiae ERD2; In S. cerevisiae: HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
Similar to S. cerevisiae TIM13; In S. cerevisiae: mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
zinc finger-containing transcription factor, putative
Similar to S. cerevisiae MCH5; In S. cerevisiae: plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes
BTB/POZ domain-containing protein, putative
arginine metabolism regulatory protein, putative
Similar to S. cerevisiae ARG81 (ARGR2); In S. cerevisiae: zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; zinc finger transcription factor, putative
zinc cluster transcription factor, putative
DNA damage-responsive transcriptional repressor, putative
Similar to S. cerevisiae RPH1; JmjC domain-containing histone demethylase, putative
Similar to S. cerevisiae VPS30; vacuolar protein sorting-associated protein, putative
tRNA-splicing endonuclease subunit, putative
transcriptional regulator complex subunit, putative
Similar to S. cerevisiae BUR6; In S. cerevisiae: subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription
high-affinity sulphate transporter, putative
Similar to S. cerevisiae SUL2; sulphate permease, putative
chromatic remodelling complex subunit, putative
Similar to S. cerevisiae CAC1 (RLF2); In S. cerevisiae: largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin; chromatin assembly factor 1 (CAF-1) subunit, putative
Similar to S. cerevisiae GRX3; In S. cerevisiae: hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
Similar to S. cerevisiae SFK1; In S. cerevisiae: believed to be involved in regulating levels of the essential phospholipid PI4P; suppressor of four kinase protein, putative
Similar to S. cerevisiae HIT1; similar to S. cerevisiae Hit1p, which is required for growth at high temperature; zinc finger-containing transcriptional regulator, putative
cell growth-regulated gene 1 protein orthologue, putative
In C. albicans: induced upon growth cessation at the yeast-hyphal transition or during planktonic growth; negative regulator of yeast-form growth, putative
In S. cerevisiae: involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; Similar to S. cerevisiae CDC123
cytosolic chaperonin complex subunit, putative
In S. cerevisiae: subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; Similar to S. cerevisiae CCT4
Similar to S. cerevisiae SAS10; In S. cerevisiae: component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
DNA-directed RNA polymerase III subunit, putative
Similar to S. cerevisiae MSH5; new intron-containing ORF from Cd_42680 and Cd_42690; intron 5'- and 3'-conserved splice sites exist, but intron seems to have slightly different branch point seq (aactaac instead of tactaac); aligns with entire C albicans ORF orf19.2713; In S. cerevisiae: protein of the MutS family required for meiotic reciprocal recombination between homologs; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; spliced gene
Similar to S. cerevisiae HCA4 (DBP4); no experimental evidence for gene function in Candida; in S. cerevisiae, putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; atp-dependent rna helicase dbp4 (ec 3.6.1.-) (dead box protein 4 (helicase ca4) (helicase uf1)
Similar to S. cerevisiae SRB2; spliced gene; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance; subunit of the RNA polymerase II mediator complex, putative
RNA polymerase II Elongator subunit, putative
Similar to S. cerevisiae ELP2; In S. cerevisiae: required for modification of wobble nucleosides in tRNA
protein phosphatase regulatory subunit, putative
Similar to S. cerevisiae GLC8; In S. cerevisiae: involved in glycogen metabolism and chromosome segregation
Similar to S. cerevisiae ZUO1; zuotin, putative
60S ribosome maturation factor, putative
Similar to S. cerevisiae SDO1; upf0023 protein ylr022c
subunit of the ubiquinol-cytochrome c reductase complex, putative
Similar to S. cerevisiae QCR9; spliced gene
cell-wall-associated glycosidase, putative
In S. cerevisiae: cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase; Similar to S. cerevisiae CRH1; chitin transglycosidase, putative
Similar to S. cerevisiae ABP1; In S. cerevisiae: actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
cytoplasmic ubiquitin-protein ligase, putative
Similar to S. cerevisiae UBR1; In C. albicans: transposon-based mutagenesis of sequence proximal to putative UBR1 ORF causes abnormal filamentous growth; In S. cerevisiae: interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
cytoplasmic tyrosyl-tRNA synthetase, putative
Similar to S. cerevisiae TYS1; In S. cerevisiae: class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr
dynamin-like GTPase, mitochondrial precursor, putative
Similar to S. cerevisiae MGM1; In S. cerevisiae: mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; mitochondrial genome maintenance protein, putative
U3 small nucleolar RNA-associated protein, putative
Similar to S. cerevisiae NAN1; In S. cerevisiae: component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; U3 snoRNP protein, putative
DNA-directed RNA polymerases I/II/III subunit, putative
Similar to S. cerevisiae RPB10; polypeptide common to RNA polymerases I, II and III, putative
Similar to S. cerevisiae CPS1; In S. cerevisiae: vacuolar carboxypeptidase; expression induced under low-nitrogen conditions
has been described as GPI-anchored cell-surface protein solely based on sequence data: De Groot PW, et al. (2003). Yeast 20(9):781-96; is an expressed ORF in C albicans, induced in hyphae and in cyr1 or efg1 null mutants: Garcia-Sanchez et al. (2005). Mol Biol Cell 16(6):2913-25; Harcus et al. (2004). Mol Biol Cell 15(10):4490-9; Similar to S. cerevisiae DAN4
transcription factor IIA (TFIIA) subunit alpha, putative
Similar to S. cerevisiae TOA1; In S. cerevisiae: involved in transcriptional activation, acts as antirepressor or as coactivator
aminophospholipid translocase (flippase), putative
ScDNF3; In S. cerevisiae: aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase; phospholipid-transporting ATPase, putative
checkpoint serine/threonine-protein kinase, putative
Similar to S. cerevisiae BUB1; In S. cerevisiae: encodes a protein kinase in complex with Mad1p and Bub3p crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
Similar to S. cerevisiae GPI16; In C. albicans: appears to be secreted protein: Monteoliva et al. (2002). Eukaryot Cell 1(4):514-25; In S. cerevisiae: encodes a transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins
elongator complex protein 5 (gamma-toxin target 5) (protein iki1) (hat-associated protein 2)
Similar to S. cerevisiae IKI1; In S. cerevisiae: required for modification of wobble nucleosides in tRNA; subunit of Elongator complex, putative
In S. cerevisiae: U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; Similar to S. cerevisiae HSH155; U2 snRNP-associated splicing factor, putative
Similar to S. cerevisiae NSE3; In S. cerevisiae: required for DNA repair and growth; non-structural maintenance of chromosome protein, putative
NADPH-dependent cytochrome P450 reductase, putative
gene functionally characterised in C maltosa: C. albicans orthologue acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed:Pierson et al. (2004). Med Mycol 42(4):385-9; Liu et al. (2005). Antimicrob Agents Chemother 49(6):2226-36
NADH:ubiquinone oxidoreductase, putative
Similar to S. cerevisiae NDI1; In S. cerevisiae: NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial precursor, putative
mitochondrial hydroxyacyl-thioester dehydratase, putative
Similar to S. cerevisiae HTD2; In S. cerevisiae: involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
Similar to S. cerevisiae RPF1; In S. cerevisiae: involved in the assembly of the large ribosomal subunit
Similar to S. cerevisiae MSN5; In S. cerevisiae: involved in nuclear import and export
Similar to S. cerevisiae MKT1; product assignment based on presence of the XPG N-terminal domain (Pfam: PF00752); single-stranded DNA endonuclease, putative
inositol 1,3,4,5,6-pentakisphosphate 2-kinase, putative
Similar to S. cerevisiae IPK1; In S. cerevisiae: nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function and is required in mRNA export from the nucleus; inositol-pentakisphosphate 2-kinase, putative
Similar to Homo sapiens AIFM2; protein encoded by putative human orthologue is an 'apoptosis-inducing factor-homologous mitochondrion-associated inducer of death'; may play a role in mediating a TP53/p53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death, and binds to DNA in a sequence-independent manner: Marshall et al. (2005). J. Biol. Chem. 280:30735-30740.; significant similarities to some dispersed regions in C albicans orf19.3362 (~50% identity)
significant similarity also to large regions in C. albicans orf19.2671 (~60% identity); Similar to S. cerevisiae NDI1; In S. cerevisiae: transfers electrons from NADH to ubiquinone in the respiratory chain, but does not pump protons
vacuolar transporter chaperone, putative
Similar to S. cerevisiae VTC4; In S. cerevisiae: encodes a vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
in-frame stop codon; apparent functional, but hypothetical gene in C. albicans
Similar to Fusarium solani DAO; has putative orthologues in many filamentous fungi (e.g. Aspergilli) and some yeasts; functionally characterised putative orthologue in Fusarium solani is a flavoprotein/oxidoreductase: Isogai et al (1990). J Biochem (Tokyo) 108(6):1063-9; FAD-dependent oxidoreductase, putative
amino acid permease-packaging chaperone, putative
In S. cerevisiae: required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; In C. albicans: required for wild-type amino-acid responsive hyphal growth and for mouse systemic virulence; Martinez and Ljungdahl (2004). Mol Microbiol 51(2):371-84; endoplasmic reticulum packaging chaperone, putative
NADH-ubiquinone oxidoreductase subunit, putative
mitochondrial 54S ribosomal protein YmL22
Yippee-like zinc-binding protein, putative
ubiquitin carboxyl-terminal hydrolase putative
Similar to S. cerevisiae UBP10; In C. albicans: putative orthologue localizes to cell surface of hyphal cells, but not yeast-form cells: Urban et al. (2003). FEBS Lett 544(1-3):228-35; repressed upon high-level peroxide stress: Enjalbert et al. (2006). Mol Biol Cell 17(2):1018-32; In S. cerevisiae: ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
catalytic subunit of the COP9 signalosome (CSN) complex, putative
Similar to S. cerevisiae RRI1; In S. cerevisiae: catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
Similar to S. cerevisiae RIM4; In S. cerevisiae: putative RNA-binding protein required for the expression of early and middle sporulation genes
In C. albicans: encodes protein containing eight 34-residue repeats; expression specific to hyphae, increases with extent of elongation of the cell; regulated by Rfg1p, Nrg1p, Tup1p, Cph1p, Efg1p, Hog1p, farnesol; may contribute to biofilm formation: Nobile et al. (2006). PLoS Pathog 2(7):e63; Nobile and Mitchell (2006). Cell Microbiol 8(9):1382-91; possibly Candida-specific
retrotransposon:solo LTR, epsilon E, truncated
DNA repair protein RAD34 orthologue, putative
Similar to S. cerevisiae RAD34; In S. cerevisiae: encodes protein involved in nucleotide excision repair
Similar to S. cerevisiae SPO75; In S. cerevisiae: encodes meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
ATP-binding cassette (ABC) transporter, putative
In C. albicans: encodes Pdrp/Cdrp family transporter of the ATP-binding cassette (ABC) superfamily; transports phospholipids in an out-to-in direction; expressed in opaque-phase cells; In S. cerevisiae: plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; opaque-specific ABC transporter, putative
signal-transducing regulatory protein, putative
Similar to Homo sapiens TRAF3; several good matches to fungal hypothetical proteins; possible orthologue in humans encodes protein involved in signal transduction: Sato et al (1995)FEBS Lett 358(2):113-8.
In S. cerevisiae: member of an oxysterol-binding protein family with seven members; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; In C. albicans: required for wild-type filamentation
Similar to Homo sapiens AP3B2; Putative orthologue in humans encodes subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) or endosomes: Newman et al. (1995). Cell 82(5):773-83; putative orthologue in S. cerevisae has somewhat less sequence similarity and encodes a beta-adaptin involved in protein trafficking from the Golgi to the vacuole/lysosome: Cowles et al (1997). Cell 91(1):109-18; Similar to S. cerevisiae APL6; subunit of the clathrin Adaptor Protein complex, putative
DNA-repair protein RAD2 orthologue, putative
Similar to S. cerevisiae RAD2; In S. cerevisiae: single-stranded DNA endonuclease involved in excision repair of DNA damaged by UV light, bulky adducts, or cross-linking agents; essential for the incision step of excision-repair; single-stranded DNA endonuclease, putative
gamma-glutamyltransferase precursor, putative
Similar to S. pombe GGT1; In S. pombe: encodes protein that has the same activity as gamma-glutamyltranspeptidases that initiate extracellular glutathione (GSH) breakdown, provide cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate: Park et al (2004). Can J Microbiol. 50(1):61-6; Similar to S. cerevisiae ECM38; In S. cerevisiae: major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation; gamma-glutamyltranspeptidase, putative
GPI-anchored cell surface glycoprotein (flocculin), putative
In C. albicans: orthologous gene encodes putative GPI-anchored cell-wall-associated protein which is repressed by TUP1p, and is part of a cell-wall-associated gene family which also includes HWP1: Braun et al (2000). Genetics 156(1):31-44.; Similar to S. cerevisiae MUC1; Similar to C. albicans HWP1; Similar to C. dubliniensis HWP1; hyphal wall protein, putative
Similar to S. cerevisiae FLO11; In S. cerevisiae: putative orthologue encodes protein required for formation of a buoyant biofilm at the cell culture broth surface, and affects cell-surface hydrophobicity; required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); shares also several regions of similarity with C albicans orf19.1321 and orf19.1327; cell surface flocculin, putative
MFS multidrug efflux transporter, putative
Similar to S. pombe FNX1; In S. pombe: encodes a membrane protein of the major facilitator superfamily that confers resistance to a variety of toxic compounds, and is induced during upon starvation; Similar to S. cerevisiae VBA1; In S. cerevisiae: permease of basic amino acids in the vacuolar membrane; vacuolar basic amino acid transporter, putative
thiamine-repressible mitochondrial transporter, putative
Similar to S. cerevisiae THI74; In S. cerevisiae: part of the THI regulon required for thiamine biosynthesis and transport
Iron/ascorbate oxidoreductase/dioxygenase family protein, putative
Similar to Rhodotorula glutinis THD; putative protein has several good matches (~40% sequence similarity) to putative oxidoreductases/dioxygenases in filamentous fungi and also some plants; no apparent orthologue in S. cerevisiae; weaker match (~35% sequence similarity) to functionally characterised protein which is a thymine dioxygenase: Smiley et al (005). Biochim. Biophys. Acta 1723:256-264; member of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily, putative; thymine dioxygenase, putative
tRNA (guanine-N(1)-)-methyltransferase, putative
Similar to S. cerevisiae TRM5; In S. cerevisiae: methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
Similar to S. cerevisiae RRP4; In S. cerevisiae: encodes protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p; ribosomal RNA processing protein, putative
peptide chain release factor, mitochondrial precursor, putative
Similar to Kluyveromyces lactis MRF1; In K. lactis: putative orthologue encodes protein that is a mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG: Pel et al (1996) Curr. Genet. 30:19-28; Similar to S. cerevisiae MRF1; In S. cerevisiae: mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
Similar to S. cerevisiae TMA17; In S. cerevisiae: putative ortholgous protein has unknown function and associates with ribosomes
methyltransferase oms1, mitochondrial precursor (ec 2.1.1.-) (oxa multicopy suppressor 1)
Similar to S. cerevisiae OMS1; In S. cerevisiae: encodes a protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations; mitochondrial methyltransferase, putative
26S proteasome regulatory subunit, putative
Similar to S. cerevisiae RPN6; In S. cerevisiae: encodes essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome
Similar to Homo sapiens NUP107; human putative orthologue encodes essential component of nuclear pore complex; required for the assembly of peripheral proteins into the nuclear pore complex and plays a role in nuclear mRNA export; Similar to S. cerevisiae NUP84; In S. cerevisiae: subunit of the nuclear pore complex (NPC); plays a role in nuclear mRNA export and NPC biogenesis; nucleoporin, putative
Similar to S. cerevisiae ATG20; In S. cerevisiae: encodes protein for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome
tRNA guanosine-2'-O-methyltransferase, putative
Similar to S. cerevisiae TRM3; In S. cerevisiae: catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; trna guanosine-2'-o-methyltransferase trm3 (ec 2.1.1.34) (trna [gm18 methyltransferase) (trna methylase 3)
exosome complex exonuclease rrp42 (ec 3.1.13.-) (ribosomal rna processing protein 42)
Similar to S. cerevisiae RRP42; In S. cerevisiae: encodes a protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p; exosome complex exonuclease, putative; ribosomal RNA processing protein, putative
Similar to S. cerevisiae ASM4; In S. cerevisiae: encodes nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
appears to be a fusion of orf19.5041 and orf19.5042
intracellular protein transport protein, putative
Similar to S. cerevisiae USO1; has some discrepancy with C. albicans ORF annotation in CGD; In S. cerevisiae: putative orthologue encodes cytoskeleton-related protein for protein transport from the ER to the Golgi complex
Similar to S. cerevisiae PTP2; overlaps with putative protein orthologue in S. cerevisiae only at C-terminal end (~250-300 terminal amino acids); In S. cerevisiae: encodes a phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
protein farnesyltransferase subunit beta, putative
Similar to Homo sapiens FNTB; In S. cerevisiae: beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; Similar to S. cerevisiae RAM1
Similar to S. cerevisiae UBX3; ubiquitin-regulatory protein, putative
signal recognition particle (SRP) subunit, putative
Similar to S. cerevisiae SRP14; In S. cerevisiae: signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
Similar to S. cerevisiae PYC2; Similar to S. cerevisiae PYC1
core RPS domain of MRS consists of five partial RPS units of 1934 bp each, plus one partial RPS unit of 1358 bp; orientation = reversed
RPS (RePeat Sequence) domain; last RPS unit is partial; RPS_6
Similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS_1
retrotransposon:solo LTR, psi H, truncated
inositol phospholipid biosynthesis protein, putative
Similar to S. cerevisiae SCS3; In S. cerevisiae: appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis
integral plasma membrane protein required for axial budding in haploid cells, putative
Similar to Mus musculus Acot9; acyl-coenzyme A thioesterase, putative
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, putative
endonuclease/exonuclease/phosphatase family protein, putative
cytochrome c oxidase assembly protein, putative
Similar to S. cerevisiae COA1; In S. cerevisiae: required for assembly of the cytochrome c oxidase complex (complex IV of the mitochondrial respiratory chain); probable mitochondrial inner membrane protein; interacts with COX1 regulatory proteins MSS1 and COX14; mitochondrial inner membrane protein, putative
RNA polymerase II transcription factor B subunit, putative
Similar to S. cerevisiae TFB1; TFIIH subunit TFB1, putative
Similar to S. cerevisiae CNE1; In S. cerevisiae: integral membrane ER chaperone involved in folding and quality control of glycoproteins
uncharacterized cell wall protein, putative
limited sequence similarity to S. cerevisiae CCW14
limited sequence similarity to S. cerevisiae CWP1
carboxylic acid transporter protein, putative
Similar to S. cerevisiae JEN1; In S. cerevisiae: lactate transporter, required for uptake of lactate and pyruvate; lactate transporter, putative
subunit of the RNA polymerase II mediator complex, putative
Similar to S. cerevisiae SOH1; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance
the DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis; product identity from Pfam hit
transporter protein of the Major Facilitator Superfamily, putative
uncharacterized protein YHR149C homologue, putative
mitochondrial integral membrane protein, putative
Similar to S. cerevisiae FZO1; In S. cerevisiae: involved in mitochondrial fusion and maintenance of the mitochondrial genome; transmembrane GTPase, putative
Similar to S. cerevisiae DAL3; In S. cerevisiae: converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation
uncharacterized protein YFR043C homologue, putative
Similar to S. cerevisiae SEC15; In S. cerevisiae: essential subunit of the exocyst complex, which is involved in the docking of exocystic vesicles with a fusion site on the plasma membrane
cytochrome c oxidase assembly protein, mitochondrial precursor, putative
Similar to S. cerevisiae COX11; In S. cerevisiae: mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase
Similar to S. cerevisiae FRE2; ferric-chelate reductase, putative
frataxin, mitochondrial precursor, putative
Similar to S. cerevisiae YFH1; In S. cerevisiae: regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
Similar to Penicillium chrysogenum pahA; phenylacetate hydroxylase, putative
Similar to S. cerevisiae RPL22A/RPL22B; spliced gene
homoaconitase, mitochondrial precursor, putative
Similar to S. cerevisiae LYS4; Similar to Candida parapsilosis LYS4; In S. cerevisiae: catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway; homoaconitate hydratase, putative
non-LTR retrotransposon Zorro 3 orf1-related protein, putative
C-terminal half of ORF2 deleted, but followed by 3' end and polyA. First ~50 codons of ORF2 also missing and replaced by inverted fragment of ORF1, preceded by polyA.
Similar to S. cerevisiae POL92; in-frame stop codons; lacks splice consensus sites; transposon pseudogene; transposable element
mitochondrial ribosomal protein, putative
Similar to S. cerevisiae MRP8; possibly fungus-specific
subunit of the Sec62/63 complex, putative
Similar to S. cerevisiae SEC66; In S. cerevisiae: non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; subunit of the endoplasmic reticulum translocation complex, putative; translocation protein Sec66 orthologue, putative
serine/threonine-protein kinase, putative
Similar to S. cerevisiae ATG1; In S. cerevisiae: required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
Similar to S. cerevisiae PAK1 (SAK1); In S. cerevisiae: upstream serine/threonine kinase for the SNF1 complex; Snf1-activating kinase
In C. albicans: roles in adhesion and virulence; secretory aspartyl protease, putative
translation elongation factor 1-beta (EF-1-beta), putative
In S. cerevisiae: stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; spliced gene
Similar to S. cerevisiae AML1; Similar to Homo sapiens N6AMT2
Similar to S. cerevisiae TFC3; In S. cerevisiae: yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding; subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC), putative
Similar to S. cerevisiae PXR1; In S. cerevisiae: essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; rRNA and snoRNA maturation protein, putative; telomerase inhibitor, putative
beta-1,3-glucanosyltransferase, putative
CaPHR1; Similar to S. cerevisiae GAS1; In C. albicans: required for apical growth and plays a role in morphogenesis; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced; In S. cerevisiae: required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; glycosidase of hyphal cell surface, putative; pH-regulated protein 1
metalloendopeptidase of the mitochondrial inner membrane, putative
Similar to S. cerevisiae OMA1; In S. cerevisiae: metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; mitochondrial metalloendopeptidase, putative
Similar to S. cerevisiae SKG1; In S. cerevisiae: localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
Similar to S. cerevisiae RCE1; In S. cerevisiae: involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
Similar to S. cerevisiae ZDS1; In S. cerevisiae: role in establishing cell polarity; interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export; may act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways; regulator of cell polarity, putative
Similar to S. cerevisiae SCS7; In S. cerevisiae: functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains; inositolphosphorylceramide-B C-26 hydroxylase, putative; sphingolipid alpha-hydroxylase, putative
Similar to S. cerevisiae RTS2; Similar to Homo sapiens KIN17; Similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication; UV response and DNA replication protein, putative; zinc finger protein, putative
ubiquitin carboxyl-terminal hydrolase, putative
Similar to S. cerevisiae UBP7; In S. cerevisiae: ubiquitin-specific protease that cleaves ubiquitin-protein fusions; ubiquitin thioesterase, putative; ubiquitin-specific-processing protease, putative
retrotransposon:solo LTR, psi I, truncated
HSP70-family chaperone protein, putative
Similar to S. cerevisiae GYP1; In S. cerevisiae: cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
NAD-dependent methylenetetrahydrofolate dehydrogenase, putative
Similar to S. cerevisiae MTD1; In S. cerevisiae: plays a catalytic role in oxidation of cytoplasmic one-carbon units
Similar to S. cerevisiae BAS1; In S. cerevisiae: involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
dolichyl-phosphate-mannose-protein mannosyltransferase, putative
In C. albicans: required for virulence in mouse systemic infection and for adhesion to endothelium; has a role in hyphal growth signaling and hygromycin B sensitivity; protein mannosyltransferase, putative
retrotransposon:solo LTR, epsilon F, truncated
endoplasmic reticulum membrane protein, putative
Similar to S. cerevisiae RTN1; reticulon-like protein, putative
tRNA (guanine-N(7)-)-methyltransferase subunit, putative
mitochondrial 54S ribosomal protein YmL11
Similar to S. cerevisiae RNT1; In S. cerevisiae: RNAase III; cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; double-stranded ribonuclease, putative
Similar to S. cerevisiae AGP3; possibly fungus-specific
topoisomerase II-associated deadenylation-dependent mRNA-decapping factor, putative
Similar to S. cerevisiae PAT1; In S. cerevisiae: also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming
Similar to S. cerevisiae RPL30; In S. cerevisiae: involved in pre-rRNA processing in the nucleolus; spliced gene
Similar to S. cerevisiae SPC34; the DASH complex is a multi-subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis; connects the centromere to the plus end of spindle microtubules; outer kinetochore protein, putative
Similar to S. cerevisiae KAE1; In S. cerevisiae: proposed to be a component of the EKC protein complex; also identified as a component of the KEOPS protein complex; glycoprotein endopeptidase, putative
Similar to S. cerevisiae CAJ1; DnaJ-family protein, putative
uncharacterized protein YCL057C homologue, putative
Similar to Homo sapiens SLC33A1; transporter protein, putative
uncharacterized membrane protein YOL092W homologue, putative
Similar to S. cerevisiae RSA4; In S. cerevisiae: involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
mitochondrial 54S ribosomal protein IMG2
Similar to S. cerevisiae SSK2; In S. cerevisiae: MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; also mediates actin cytoskeleton recovery from osmotic stress; serine/threonine protein kinase, putative
serine/threonine-protein phosphatase, putative
appears to be a fusion of orf19.3772 and orf19.3773; Similar to S. cerevisiae RNT1; In S. cerevisiae: involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; ribonuclease III, putative
acetylornithine aminotransferase, mitochondrial precursor, putative
zinc ion transmembrane transporter, putative
Similar to S. cerevisiae ZRG17; zinc-regulated endoplasmic reticulum protein, putative
Similar to S. cerevisiae SRB8; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
malonate-semialdehyde dehydrogenase [acylating], putative
Similar to S. cerevisiae ALD4; In S. cerevisiae: required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; Similar to Homo sapiens ALDH6A1; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor, putative; mitochondrial aldehyde dehydrogenase, putative
putative glycogen debranching enzyme (glycogen debrancher) [includes: 4-alpha glucanotransferase (ec 2.4.1.25) (oligo-1,4-1,4-glucantransferase) amylo-alpha-1,6-glucosidase (ec 3.2.1.33) (amylo-1,6-glucosidase (dextrin 6-alpha-d-glucosidase)]
Similar to S. cerevisiae GDB1; required for glycogen degradation
In C. albicans: required for vacuolar inheritance and normal hyphal branching; Similar to S. cerevisiae VAC8
cytosolic Fe-S cluster assembling factor, putative
Similar to S. cerevisiae NBP35; nucleotide-binding protein, putative
Similar to S. cerevisiae NUP100; In S. cerevisiae: subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; nucleoporin, putative
enhancer of mRNA-decapping protein, putative
Similar to S. cerevisiae EDC3; In S. cerevisiae: non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
CDP-diacylglycerol-inositol 3-phosphatidyltransferase, putative
Similar to S. cerevisiae PIS1; In S. cerevisiae: required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins; phosphatidylinositol synthase, putative
Anaphase Promoting Complex subunit, putative
Similar to S. cerevisiae APC5; In S. cerevisiae: subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
Similar to S. cerevisiae VPH1; In S. cerevisiae: subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
Similar to S. cerevisiae ELP1 (IKI3); In S. cerevisiae: subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator
DNA repair and recombination protein, putative
Similar to S. cerevisiae RAD52; In S. cerevisiae: protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA
ER to Golgi vesicle transport protein, putative
Similar to S. cerevisiae USO1; In S. cerevisiae: essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex; intracellular protein transport protein, putative
Similar to S. cerevisiae ABZ1; para-aminobenzoate (PABA) synthase, putative
Similar to S. cerevisiae XKS1; In S. cerevisiae: converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; xylulose kinase
lysine-2-oxoglutarate reductase, putative
Similar to S. cerevisiae LYS1; saccharopine dehydrogenase, [NAD+, L-lysine-forming], putative
from SGD involved in an early, nucleolar step of 60S ribosomal subunit biogenesis, putative
Similar to S. cerevisiae MAK11; In S. cerevisiae: protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; ribosomal biogenesis protein, putative
subunit of the anaphase-promoting complex/cyclosome (APC/C, putative)
Similar to S. cerevisiae CDC16; In S. cerevisiae: subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; ubiquitin-protein ligase, putative
phosphatidylinositol 3,5-bisphosphate-binding protein, putative
Similar to S. cerevisiae PUF3; In S. cerevisiae: protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; mRNA-binding protein involved in RNA catabolism, putative
tuberin (a tuberous sclerosis homolog protein) specifically stimulates the intrinsic GTPase activity of Ras-related protein Rap1A suggesting a possible mechanism for its role in the regulation of cellular growth; Similar to S. pombe TSC2; Rap/ran-GTPase-activating protein, putative
Similar to S. cerevisiae GAP1; In S. cerevisiae: localization to the plasma membrane is regulated by nitrogen source
Similar to S. cerevisiae TPA1; In S. cerevisiae: protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; termination and polyadenylation protein, putative
core RPS block consists of only one single partial repeat unit of 1535 bp; orientation = forward
degraded pseudogene in HOK region of MRS_2
RPS (RePeat Sequence) domain; single, partial RPS unit of 1535 bp
similar to Candida dubliniensis, Q8TGW0; apparently rearranged pseudogene
Similar to S. cerevisiae HOM3; In S. cerevisiae: cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; aspartate kinase or aspartokinase, putative; aspartate kinase, putative
aromatic amino acid aminotransferase, putative
Similar to S. cerevisiae ARO9; In S. cerevisiae: catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
In S. cerevisiae: involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; spliced gene; tubulin gamma chain, putative
Similar to S. cerevisiae MDR1 (GYP2); In S. cerevisiae: cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
DNA-directed RNA polymerase II subunit, putative
phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase, putative
Similar to S. cerevisiae HIS6; In S. cerevisiae: catalyzes the fourth step in histidine biosynthesis
Similar to S. cerevisiae FAF1; ribosome biogenesis protein, putative
subunit of the condensin complex, putative
Similar to S. cerevisiae BRN1; In S. cerevisiae: essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics
subunit of the mitochondrial inner membrane i-AAA protease complex, putative
Similar to S. cerevisiae YME1; In S. cerevisiae: subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products
Similar to S. cerevisiae SEC23; In S. cerevisiae: TPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; subunit of the COPII vesicle coat protein complex, putative
Similar to C. albicans ZCF5; possibly fungus-specific
retrotransposon:solo LTR, rho E, truncated
C-terminal end of ORF2 and start of 3' UTR, separated from 4D by very A-rich segment
weak similarity (E=4.5e-07) to orf19.559
retrotransposon:solo LTR, lambda, truncated
retrotransposon:solo LTR, sampi E, truncated
subunit of the prefoldin complex, putative
Similar to S. cerevisiae GIM3; In S. cerevisiae: subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
retrotransposon:solo LTR, pi E, internal deletion
retrotransposon:solo LTR, epsilon U, truncated
Similar to S. cerevisiae FRE4; ferric-chelate reductase, putative
iron-sulfur protein biogenesis, desulfurase-interacting protein, putative
Similar to S. cerevisiae ISD11; In S. cerevisiae: required for mitochondrial iron-sulfur cluster biosynthesis
Similar to S. cerevisiae DJP1; In S. cerevisiae: required for peroxisomal protein import and involved in peroxisome assembly
Similar to S. cerevisiae CEG1; In S. cerevisiae: alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; mRNA guanylyltransferase, putative; mRNA-capping enzyme subunit alpha, putative
Similar to S. cerevisiae SNT2; the LID2 complex is thought to be involved in regulation of chromatin remodelling; subunit of the LID2 complex, putative
nitrogen regulatory GATA-factor, putative
In C. albicans: zinc finger transcriptional regulator of nitrogen utilization; required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan N sources; required for virulence in a mouse systemic infection model; transcriptional activator with GATA-1-type Zn finger DNA-binding motif, putative
vacuolar protein sorting protein, putative
NGG1-interacting factor orthologue, putative
Similar to S. cerevisiae NIF3; In S. cerevisiae: protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; spliced gene; uncharacterized protein
putative ectonucleotide pyrophosphatase/phosphodiesterase, [includes: alkaline phosphodiesterase (ec 3.1.4.1); nucleotide pyrophosphatase (ec 3.6.1.9)]
Similar to S. cerevisiae NPP1; In S. cerevisiae: nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase, putative
Similar to S. cerevisiae ALG1; In S. cerevisiae: mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); chitobiosyldiphosphodolichol beta-mannosyltransferase, putative
Similar to S. cerevisiae REV1; In S. cerevisiae: forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA; deoxycytidyl transferase, putative
In S. cerevisiae: Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways); also known as CaM; spliced gene; calmodulin, putative
from SGD-Protein of unknown function, involved in sporulation, vacuolar protein sorting and protein-Golgi retention, putative
Similar to S. cerevisiae VPS13; In S. cerevisiae: protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention; vacuolar protein sorting-associated protein, putative; vacuolar protein-targeting protein, putative
methionyl-tRNA formyltransferase, mitochondrial precursor, putative
Similar to S. cerevisiae FMT1; In S. cerevisiae: methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; methionyl-tRNA transformylase, putative
mannosyl-oligosaccharide glucosidase, putative
Similar to S. cerevisiae CWH41; In C. albicans: involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan; In S. cerevisiae: processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; processing alpha glucosidase, putative
Similar to S. cerevisiae TRP5; In S. cerevisiae: tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis
NADP-specific glutamate dehydrogenase, putative
Similar to S. cerevisiae GDH3; In S. cerevisiae: NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate
Similar to S. cerevisiae NUM1; In S. cerevisiae: protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
Similar to S. cerevisiae HOP2; spliced gene; In S. cerevisiae: meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
alpha-tubulin assembly protein, putative
Similar to S. cerevisiae PAC2; In S. cerevisiae: microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function
Similar to S. cerevisiae TMA20; In S. cerevisiae: protein of unknown function that associates with ribosomes and has a putative RNA binding domain
Similar to S. cerevisiae MPH1; DEAD box helicase, putative
Similar to S. cerevisiae NUG1; In S. cerevisiae: associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
Similar to S. cerevisiae YND1; In S. cerevisiae: apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; Golgi apyrase, putative
subunit of the exocyst complex, putative
Similar to S. cerevisiae SEC3; In S. cerevisiae: subunit of the exocyst complex, which mediates targeting of post-Golgi vesicles to sites of active exocytosis
Similar to S. cerevisiae ERG26; In C. albicans and in S. cerevisiae: catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; sterol-4-alpha-carboxylate 3-dehydrogenase, putative
component of the EKC/KEOPS complex, putative
Similar to S. cerevisiae PCC1; In S. cerevisiae: proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens; polarized growth chromatin-associated controller, putative; transcription factor, putative
Similar to Arabidopsis thaliana AGO1; RNA interference and gene silencing protein, putative
subunit of the nuclear pore complex, putative
(R)-2-octanol dehydrogenase protein, putative
Similar to Pichia finlandica ODH; short-chain dehydrogenase/reductase (SDR) family protein, putative
Similar to S. cerevisiae BOR1; plasma membrane anion transporter, putative
Similar to Trichoderma reesei LXR1; In C. albicans: not required for utilization of L-sorbose; short chain dehydrogenase (SDR) family protein, putative
In C. albicans: enzyme involved in utilization of L-sorbose; has sorbitol dehydrogenase, fructose reductase, and sorbose reductase activities; has NAD-binding site motif; transcriptional regulation affected by chromosome 5 copy number; sorbose reductase, putative
Similar to S. cerevisiae VMA8; In S. cerevisiae: subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; vacuolar proton pump subunit, putative
component of the spliceosome complex, putative
Similar to S. cerevisiae SYF1; In S. cerevisiae: component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; pre-mRNA-splicing factor, putative
Similar to S. cerevisiae AFG1; In S. cerevisiae: may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; mitochondrial chaperonin, putative
Similar to S. cerevisiae ISE6; component of the INO80 chromatin remodeling complex, putative
uncharacterised protein YMR295C homologue, putative
LTR, + gag ORF sections + LTR on opposite strand
In C. albicans: regulates mating and invasive hyphal growth under some conditions; MAP kinase, putative
Similar to S. cerevisiae PRI2; synthesizes small RNA primers for Okazaki fragment synthesis; required for DNA synthesis and double-strand break repair
FACT (FAcilitates Chromatin Transcription) complex subunit, putative
Similar to S. cerevisiae CDC68; In S. cerevisiae: the FACT complex facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; In C. albicans: antifungal target; Facilitates Chromatin Transcription (FACT) subunit protein, putative; cell division control protein 68 orthologue, putative; chromatin remodelling protein, putative; transcription elongation factor, putative
retrotransposon:solo LTR, moa B, truncated
high-capacity xanthine-uric acid/H+ symporter
positive regulator of mannosylphosphate transferase, putative
In S. cerevisiae: putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; In C. albicans: protein required for normal mannosylphosphorylation of oligosaccharides linked to cell wall proteins, not required for virulence or kidney colonization in mouse systemic infection or for normal interaction with macrophage
centromere DNA binding protein, putative
spliced gene; transcriptional activator of sulphur metabolism, putative
CaTOP2; Similar to S. cerevisiae TOP2; In S. cerevisiae: essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
flavoprotein subunit of succinate dehydrogenase, putative
Similar to S. cerevisiae SDH1; In S. cerevisiae: couples the oxidation of succinate to the transfer of electrons to ubiquinone
Similar to S. cerevisiae VPS5; In S. cerevisiae: nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; structural component of the retromer membrane coat complex, putative; vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae SMY2; In S. cerevisiae: protein of unknown function that interacts with Myo2p
spliced gene; Similar to S. cerevisiae UMP1; In S. cerevisiae: short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
uncharacterized membrane protein YML131W homologue, putative
Similar to S. cerevisiae NOP1; In S. cerevisiae: nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA
Similar to S. cerevisiae UBX2 (SEL1); In S. cerevisiae: protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; ubiquitin-dependent degradation protein, putative
glycerol-3-phosphate dehydrogenase, mitochondrial precursor, putative
Similar to S. cerevisiae MSC2; In S. cerevisiae: member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; zinc ion transporter, putative
Similar to S. cerevisiae RVB1; In S. cerevisiae: involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family; chromatin remodelling complex protein, putative
Similar to S. cerevisiae SLY1; In S. cerevisiae: hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
Zn(2)-C6 fungal-type DNA-binding protein, putative
zinc finger-containing transcriptional regulator, putative
Similar to S. cerevisiae CCT6; In S. cerevisiae: essential protein that is required for the assembly of actin and tubulins in vivo; molecular chaperone, putative; subunit of the cytosolic chaperonin Cct ring complex, putative
methionine aminopeptidase precursor, putative
Similar to S. cerevisiae MAP1; In S. cerevisiae: catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides
Similar to S. cerevisiae CDD1; spliced gene; cytidine deaminase, putative
Similar to S. cerevisiae RPT5; In S. cerevisiae: one of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription
26S proteasome complex subunit, putative
Similar to S. cerevisiae SEM1; In S. cerevisiae: component of the lid subcomplex of the regulatory subunit of the 26S proteasome
Similar to S. cerevisiae ACR3; plasma membrane arsenite transporter, putative
also shows homology to S. cerevisiae URE2 involved in nitrogen catabolite repression; Similar to S. pombe GST1
uncharacterized ABC transporter, putative
protein associated with the U1 snRNP complex, putative
Similar to S. cerevisiae LUC7; In S. cerevisiae: essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; splicing factor involved in recognition of 5' splice site, putative
Similar to S. cerevisiae PUS5; In S. cerevisiae: catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; pseudouridylate synthase, putative; uracil hydrolyase, putative
CipC-like antibiotic response protein, putative
Similar to Aspergillus funigatus CipC; CipC is a major hyphal protein of Aspergillus fumigatus
high-affinity zinc transport protein, putative
Similar to S. cerevisiae ZRT1; zinc-regulated transporter, putative
In C. albicans: ediates leukocyte adhesion, induces migration; binds integrin alphaMbeta2; immunogenic in mouse; at hyphal cell surface, not yeast-form; produced at ambient pH; Rim101p induced; 17-beta-estradiol, ethynyl estradiol downregulated; hypha-specific cell wall protein, putative; pH-regulated antigen, putative
Similar to S. cerevisiae MNN4; In S. cerevisiae: involved in mannosylphosphorylation of N-linked oligosaccharides
6-O-methylguanine-DNA methyltransferase, putative
Similar to S. cerevisiae MGT1; Repairs alkylated guanine (O6-methylguanine) in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme; DNA repair methyltransferase, putative
3'-phosphoadenylylsulfate reductase, putative
Similar to S. cerevisiae MET16; possibly fungus-specific; In S. cerevisiae: reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; phosphoadenosine phosphosulfate reductase, putative
Similar to S. cerevisiae DIT2; In S. cerevisiae: N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; cytochrome P-450, putative
Similar to S. cerevisiae YDC1; In S. cerevisiae: alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine
anthranilate phosphoribosyl transferase, putative
In S. cerevisiae: anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis; Similar to S. cerevisiae TRP4
Similar to S. cerevisiae BRR2; In S. cerevisiae: RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis
E1 alpha subunit of the pyruvate dehydrogenase complex, mitochondrial precursor, putative
Similar to S. cerevisiae PDA1; In S. cerevisiae: catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated
DNA mismatch repair protein MSH2, putative
Similar to S. cerevisiae MSH2; yeast homologue of E. coli MutS
ubiquitin-40S ribosomal protein S31 fusion protein
Similar to S. cerevisiae RPS31; In S. cerevisiae: fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
Similar to S. cerevisiae SEC10; In S. cerevisiae: subunit of the exocyst complex, which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
Mn++ homeostasis regulatory protein, putative
Similar to S. cerevisiae CDC1; In S. cerevisiae: putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution; cell division control protein CDC1 orthologue, putative
subunit of the SAS acetyltransferase complex, putative
Similar to S. cerevisiae SAS4; In S. cerevisiae: subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
sister chromatid cohesion protein, putative
Similar to S. cerevisiae SCC2; In S. cerevisiae: subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; subunit of cohesin loading factor, putative
chromatin modification-related protein, putative
Similar to S. cerevisiae VID21; subunit of the NuA4 histone acetyltransferase complex, putative
retrotransposon:huia A, partial Tcd16 (subtelomeric), LTR
non-LTR retrotransposon zorro 3 orf1-related protein
Similar to C. albicans FGR13; transposable element
LINE:4F, Zorro4, partial ORF1 (subtelomeric)
Similar to C. albicans YRF1, (HPR5); incomplete sequence, no splice junction consensus, apparent pseudogene