Candida dubliniensis CD36 chromosome 3, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992690.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
tranposable element; incomplete sequence; in-frame stop codon
Gag & PR ORFs + duplicated fragment, (subtelomeric)
retrotransposon tca3 polyprotein, putative
transposable element; Similar to S. cerevisiae POL94
retrotransposon-related protein, putative
component of spliceosome involved in mRNA splicing, putative
mRNA polyadenylation regulating protein, putative
Similar to S. cerevisiae PBP1; In S. cerevisiae: interacts with poly(A)-binding protein Pab1p, and is probably involved in controlling the extent of mRNA polyadenylation
vacuolar transporter chaperone (VTC), putative
Similar to S. cerevisiae ETR1; enoyl-[acyl-carrier protein] reductase [NADPH, B-specific], mitochondrial precursor, putative; mitochondrial respiratory function protein, putative (EC 1.3.1.38); trans-2-enoyl-CoA reductase, putative (EC 1.3.1.10)
appears to be fusion of orf19.5447 and orf19.5446; Similar to S. cerevisiae ITR1; sugar transporter, putative
ADP-ribosylation factor GTPase-activating protein (ARF GAP), putative
Similar to S. cerevisiae GLO3; In S. cerevisiae: involved in ER-Golgi transport
import inner membrane translocase subunit, mitochondrial precursor, putative
Similar to S. cerevisiae TIM44; translocase of the inner mitochondrial membrane component, putative
Similar to S. cerevisiae BNA4; kynurenine 3-monooxygenase, putative
GTPase activating protein (GAP), putative
Similar to S. cerevisiae GYL1; sequence similarity to GAP proteins is low
ubiquitin-like-specific protease, putative
Similar to S. cerevisiae ULP2; In S. cerevisiae: peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
26s protease regulatory subunit, putative
Similar to S. cerevisiae RPT2; ATPase subunit of proteasome
In S. cerevisiae: mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
U3 small nucleolar RNA-associated protein, putative
Similar to S. cerevisiae UTP8; U3 snoRNA-associated protein, putative
protein FMP36 (found in mitochondrial proteome protein 36) homologue, mitochondrial precursor, putative
Similar to S. cerevisiae FMP36; uncharacterized mitochondrial protein, putative
Similar to S. cerevisiae BUD21; bud site selection protein, putative
DNA replication origin binding protein, putative
Similar to S. cerevisiae DIA2; Possibly involved in regulation of invasive and pseudohyphal growth; protein Dia2 (digs into agar protein 2) homologue, putative
Similar to S. cerevisiae ATX2; metal ion transporter, putative
Similar to S. cerevisiae TRZ1; tRNA 3' processing endoribonuclease, putative; tRNase Z, putative
mitochondrial 54S ribosomal protein RML2
ATP synthase subunit, mitochondrial precursor, putative
Similar to S. cerevisiae ATP5; In S. cerevisiae: subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
uncharacterized protein yil039w homologue, putative
In S. cerevisiae: GFP-fusion protein localizes to the endoplasmic reticulum
Similar to S. cerevisiae DOT5; peroxiredoxin, putative; thioredoxin peroxidase, putative
histone acetyltransferase subunit, putative
Similar to S. cerevisiae UBC12; ubiquitin carrier protein, putative
microtubule plus-end binding protein, putative
Similar to S. cerevisiae PAC1; In S. cerevisiae: protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; nuclear distribution protein Pac1 homologue, putative
increased sodium tolerance protein 1 homologue, putative
Similar to S. cerevisiae IST1; computational analysis of large-scale protein-protein interaction data in S. cerevisiae suggests that this protein is a translation initiation factor; translation initiation factor, putative
serine/threonine-protein kinase, putative
U3 small nucleolar RNA-associated protein Sof1 homologue, putative
Similar to S. cerevisiae SOF1; In S. cerevisiae: essential protein required for biogenesis of 40S (small) ribosomal subunit; ribosome biogenesis protein, putative
plasma membrane-associated protein phosphatase, putative
appears to be a fusion of orf19.5404 and orf19.5401; Similar to Pichia stipitis HYR5.1; hyphally regulated cell wall protein (fragment), putative
hyphally regulated cell wall protein, putative
conserved oligomeric Golgi complex subunit, putative
Similar to S. cerevisiae COG7; In S. cerevisiae: comoponent of a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
protein Pet191 homologue, mitochondrial precursor, putative
spliced gene; Similar to S. cerevisiae PET191; protein required for assembly of cytochrome c oxidase, putative
regulator of (H+)-ATPase in vacuolar membrane, putative
Similar to S. cerevisiae RAV1; regulator of V-ATPase in vacuolar membrane, putative
cysteine sulfinic acid decarboxylase (EC 4.1.1.29), putative
Similar to Carassius auratus (Goldfish) GAD65; Mus musculus Gad2; Mus musculus Csad; g1utamic acid decarboxylase (EC 4.1.1.15), putative
Similar to S. cerevisiae RSE1; In S. cerevisiae: associates with U2 snRNA and is involved in ER to Golgi transport; pre-spliceosome component, putative
spliced gene; Similar to S. cerevisiae FKH2; possible role in virulence; forkhead family transcription factor, putative
COMPASS histone methyltransferase subunit, putative
Similar to S. cerevisiae SWD1; In S. cerevisiae: required for transcriptional silencing near telomeres; subunit of the COMPASS (Set1C) complex, putative
vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae VPS8; In S. cerevisiae: membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; vacuolar sorting protein, putative
Similar to S. cerevisiae CHS2; chitin-UDP acetyl-glucosaminyl transferase, putative
Similar to S. cerevisiae PUF4; In S. cerevisiae: member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
lysine biosynthesis regulatory protein, putative
Similar to S. cerevisiae LYS14; transcription factor with zinc cluster DNA-binding motif, putative
Similar to S. cerevisiae ERG4; In S. cerevisiae: catalyzes the final step in ergosterol biosynthesis
alpha subunit of the 20S core complex of the 26S proteasome, putative
Similar to S. cerevisiae SCL1; proteasome component, putative
Similar to S. cerevisiae HOS2; In S. cerevisiae: required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
Similar to S. cerevisiae PAK1; serine/threonine-protein kinase, putative
Similar to S. cerevisiae MIH1; In S. cerevisiae: regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25; protein tyrosine phosphatase, putative
multifunctional beta-oxidation protein, putative
multifunctional protein: 2-enoyl-coa hydratase (ec 4.2.1.-); d-3-hydroxyacyl coa dehydrogenase (ec 1.1.1.-)]; peroxisomal hydratase-dehydrogenase-epimerase, putative
dihydroxyacetone phosphate sn-1 acyltransferase (ec 2.3.1.42), putative
Similar to S. cerevisiae GPT1; In S. cerevisiae: dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids; glycerol 3-phosphate sn-1 acyltransferase (ec 2.3.1.15), putative; glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase, putative
DNA ligase I, mitochondrial precursor, putative
Similar to S. cerevisiae CDC9; polydeoxyribonucleotide synthase [ATP]
uncharacterized protein YER093C-A homologue, putative
uncharacterized protein ymr031c homologue, putative
chromosome segregation protein, putative
Similar to S. cerevisiae CSE4; homologue of human CENP-A; In S. cerevisiae: required for proper kinetochore function; histone H3-like centromere protein, putative
2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor, putative
Similar to S. cerevisiae KGD1; In S. cerevisiae: component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; alpha-ketoglutarate dehydrogenase, putative
NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase, putative
Similar to S. cerevisiae AYR1; In S. cerevisiae: found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones; oxidoreductase, putative
Similar to S. cerevisiae NUF1; In S. cerevisiae: involved in connecting nuclear microtubules to spindle pole body
Similar to S. cerevisiae ADY2; In S. cerevisiae: required for normal sporulation
Similar to S. cerevisiae ATO2; In S. cerevisiae: putative transmembrane protein, involved in the export of ammonia, a starvation signal that promotes cell death in the center of aging colonies
Similar to S. cerevisiae SAN1; In S. cerevisiae: involved in the proteasome-dependent degradation of aberrant nuclear proteins
Similar to S. cerevisiae CPR7; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; cyclosporin-sensitive proline rotamase, putative; peptidyl-prolyl cis-trans isomerase, putative
apparent pseudogene; missing translational start codon and upstream sequences; Similar to S. cerevisiae LPF37; No apparent C. albicans orthologue at this locus; only putative gene relic
Similar to S. cerevisiae FLC3; flavin carrier protein precursor, putative
Similar to S. cerevisiae BMS1; In S. cerevisiae: required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; ribosome biogenesis protein, putative
Similar to S. cerevisiae ARP9; In S. cerevisiae: component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation; actin-like protein, Arp9 homologue, putative; chromatin structure-remodeling complex protein, putative
protein Cin1 (chromosome instability protein 1) homologue, putative
Similar to S. cerevisiae CIN1; tubulin-folding cofactor, putative
mitochondrial ribosomal protein, large subunit
protein disulfide-isomerase precursor, putative
Actin Patches Distal protein 1 homologue, putative
Similar to S. cerevisiae APD1; In S. cerevisiae: function unknown, but required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide
1-phosphatidylinositol-4-phosphate kinase, putative
Similar to S. cerevisiae MSS4; In S. cerevisiae: involved in actin cytoskeleton organization and cell morphogenesis; phosphatidylinositol-4-phosphate 5-kinase, putative
uncharacterized sialophosphoprotein, putative
cytoplasmic protein required for sporulation, putative
Similar to S. cerevisiae RMD1; In S. cerevisiae: required for meiotic nuclear division; protein RMD1 homologue, putative
Similar to S. cerevisiae NHP10; In S. cerevisiae: likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex; high mobility group protein, putative; non-histone DNA-binding protein, putative
nearly complete apart from small deletion where LINE 3C is inserted.
transposable element; apparent genomic rearrangement
polyprotein of L1-like non-LTR retrotransposon zorro 3
transposable element; Similar to S. cerevisiae POL92
possible non-LTR retrotransposon Zorro family polyprotein
transposable element; Similar to S. cerevisiae POL91
non-LTR retrotransposon Zorro 3 ORF1-related protein
zinc finger transcription factor, putative
Similar to S. cerevisiae PMC1; vacuolar ca(2+)-ATPase, putative
Similar to S. cerevisiae MUC1; In S. cerevisiae: GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth; cell surface flocculin with structure similar to serine/threonine-rich GPI-anchored cell wall proteins; Sequence similarity to human mucins; proteophosphoglycan
uncharacterized protein yjl055w homologue, putative
Similar to S. cerevisiae NCE103; In S. cerevisiae: involved in non-classical protein export pathway
Similar to S. cerevisiae SGA1; fungal-specific; In S. cerevisiae: intracellular sporulation-specific glucoamylase involved in glycogen degradation; glucoamylase, putative
fungal zinc cluster transcription factor, putative
mitochondrial ornithine carrier protein, putative
orotidine 5'-phosphate decarboxylase, putative
uridine 5'-monophosphate synthase, putative
transcription factor involved in iron utilization, putative
similar to retrotransposon tca3 polyprotein
ARF guanine-nucleotide exchange factor, putative
Similar to S. cerevisiae GEA2; In S. cerevisiae: guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization
Similar to S. cerevisiae END3; In S. cerevisiae: involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis
NADH-ubiquinone oxidoreductase subunit, mitochondrial precursor, putative
oleate-induced peroxisomal protein, putative
appears to be not present in S. cerevisiae
uncharacterized protein yil127c, putative
In S. cerevisiae: GFP-fusion protein localizes to the nucleolus
DNA repair and TFIIH regulator, putative
Similar to S. cerevisiae MET18; In S. cerevisiae: required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
3-ketoacyl-CoA thiolase A, peroxisomal precursor, putative
Similar to S. cerevisiae POT1; 3-oxoacyl CoA thiolase, putative; peroxisomal oxoacyl thiolase, putative
spliced gene; Similar to S. cerevisiae ARF3
Similar to S. cerevisiae RKI1; ribose-5-phosphate isomerase, putative; ribose-5-phosphate ketol-isomerase, putative
SH3 domain protein implicated in the regulation of actin polymerization, putative
Similar to S. cerevisiae BZZ1; In S. cerevisiae: recruits actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
actin filament organizing protein, putative
Similar to S. cerevisiae APP1; In S. cerevisiae: computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization; actin patch protein, putative
translation machinery-associated protein, putative
Similar to S. cerevisiae TMA46; In S. cerevisiae: protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
cell morphogenesis and proliferation regulator, putative
Similar to S. cerevisiae TAO3; transcription factor, putative
Similar to S. cerevisiae TOS1; described in CGD as being similar to alpha agglutinin anchor subunit
pre-mRNA-splicing factor ATP-dependent RNA helicase, putative
Similar to S. cerevisiae PRP43; In S. cerevisiae: RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
appears to be a fusion of orf19.1685 and orf19.1684; Similar to Candida albicans ZCF7
serine/threonine-protein phosphatase type 2A, catalytic subunit, putative
Similar to S. cerevisiae PPH21; In S. cerevisiae: involved in signal transduction and regulation of mitosis
NADH-ubiquinone oxidoreductase subunit, putative
Similar to Ashbya gossypii VMA1; vacuolar ATP synthase catalytic subunit, putative; vacuolar proton pump subunit, putative
uncharacterized protein ydl183c, putative
uncharacterized membrane protein ydl133w, putative
cell division control protein 53 homologue, putative
Similar to S. cerevisiae CDC53; In S. cerevisiae: structural protein of SCF complexes involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; cullin-A, putative; subunit of E3 ubiquitin ligase complex SCF, putative
serine/threonine-protein phosphatase T, putative
alpha subunit of COPI vesicle coatomer complex, putative
Similar to S. cerevisiae COP1; In S. cerevisiae: alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway; coatomer subunit alpha, putative
Similar to S. cerevisiae UTR2; In S. cerevisiae: cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; has a role in cell wall maintenance; glycosidase precursor, putative
Similar to S. cerevisiae BRO1; In C. albicans: protein involved in transport from multivesicular body to vacuole; In S. cerevisiae: cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway
mitochondrial respiratory chain complexes assembly protein, putative
Similar to S. cerevisiae AFG3; In S. cerevisiae: component of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
uncharacterized protein YLR218C homologue, putative
Similar to S. cerevisiae RAD16; DNA repair protein Rad16 homologue, putative
In C. albicans: adds second mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; fungal-specific; glycolipid 2-alpha-mannosyltransferase, putative
pseudogene orthologue of orf19.1664; in-frame stop codons; no splice consensus sequences
Similar to S. cerevisiae KRE2; glycolipid 2-alpha-mannosyltransferase, putative
mitochondrial 37S ribosomal protein MRP1
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, putative
Similar to S. cerevisiae ALG8; In S. cerevisiae: involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase, putative; glycosyl transferase, putative
uncharacterized protein ydr348c homologue, putative
phosphatidyl inositol 3-phosphate binding protein, putative
Similar to S. cerevisiae PIB2; In S. cerevisiae: involved in telomere-proximal repression of gene expression
probably involved in the fatty acid beta-oxidation pathway; fatty-acyl coenzyme A oxidase, putative
uncharacterized membrane protein yhr140w homologue, putative
maps to C-terminal part of orf19.1653 in C.albicans; appears to have been integration site for transposable element in C. dubliniensis; see Cd36_81850 for N-terminal part of CDS; apparently fungus-specific
retrotransposon tca4 polyprotein, putative
retrotransposon tca2 polyprotein, putative
transposable element; Similar to S. cerevisiae POL97
maps to N-terminal part of orf19.1653 in C.albicans; appears to have been integration site for transposable element in C. dubliniensis; see Cd36_81810 for C-terminal part of CDS; apparently fungus-specific
apparent frameshift in coding sequence; no C. albicans positional orthologue at this locus; dipeptidyl arylamidase, putative; dipeptidyl-peptidase, putative
core RPS block consists of a single partial RPS unit of 1530bp; orientation=anti-sense
apparent pseudogene; in-frame stop codon and no splice consensii; appears to be (imperfectly) repeated on other side of MRS - see Cd36_81940
RPS (RePeat Sequence) domain; single, partial RPS unit
appears to be a rearranged, partial and inactivated isocitrate dehydrogenase pseudogene; Similar to S. pombe IDH1
transposable element; Similar to C. albicans POL94
transposable element; Similar to Candida albicans POL94
transposable element; Similar to Candida albicans POL95
appears to be (imperfectly) repeated on other side of the MRS - Cd36_81870; truncated pseudogene: consists of only C-terminal third of CDS (aa336-516)
probably involved in the fatty acid beta-oxidation pathway
mitochondrial import receptor subunit, putative
Similar to S. cerevisiae TOM6; In S. cerevisiae: component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex; translocase of outer membrane, putative
Similar to S. cerevisiae RNA1; In S. cerevisiae: involved in rna production/processing; RaN GTPase-activating protein homologue, putative
DNA repair protein Rad50 homologue, putative
Similar to S. cerevisiae RAD50; possible alternate upstream translation initiation site; In S. cerevisiae: involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
protein mum3 (muddled meiosis protein 3) homologue, putative
In S. cerevisiae: involved in the organization of the outer spore wall layers; sequence similarity to the tafazzins superfamily of acyltransferases has been noted (SGD: YOR298W)
multiple RNA-binding domain-containing protein, putative
Similar to S. cerevisiae MRD1; In S. cerevisiae: essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites
Similar to S. cerevisiae PCP1; In S. cerevisiae: mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
Similar to S. cerevisiae LOC1; In S. cerevisiae: nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; regulator of mRNA localization, putative
alpha-ketoglutarate-dependent sulfonate dioxygenase, putative
Similar to S. cerevisiae JLP1; In S. cerevisiae: nvolved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain; dnaJ-like protein, putative
Similar to S. cerevisiae SEC23; In S. cerevisiae: component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; protein transport protein Sec23 homologue, putative
Similar to S. cerevisiae STE50; In S. cerevisiae: involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; protein kinase regulator, putative
Similar to S. cerevisiae RPL12A/RPL12B; RPL12A and RPL12B are almost identical (SGD)
acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI)/endozepine (EP), putative
spliced gene; Similar to S. cerevisiae ACB1; In S. cerevisiae: transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
Similar to S. cerevisiae UTP4; In S. cerevisiae: nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; U3 snoRNA-associated protein, putative
Similar to S. cerevisiae DCW1; putative mannan endo-1,6-alpha-mannosidase precursor, putative
delta(24)-sterol c methyltransferase, putative
In S. cerevisiae: converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; sterol 24-c-methyltransferase, putative
In S. cerevisiae: high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing; spliced gene; suppressor of DNA polymerase and splicing mutations protein, putative
vacuolar aminopeptidase precursor, putative
Similar to S. cerevisiae APE1; vacuolar aminopeptidase, putative
Similar to S. cerevisiae DYS1; In S. cerevisiae: catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels
N-terminal acetyltransferase C complex subunit, putative
spliced gene; Similar to S. cerevisiae MAK10; In S. cerevisiae: required for replication of dsRNA virus
AP-1-like transcription factor, putative
Similar to S. cerevisiae YAP1; In S. cerevisiae: basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants; jun-like transcription factor, putative
Similar to S. cerevisiae YCG1; In S. cerevisiae: subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex
Similar to S. cerevisiae GPA2; In S. cerevisiae: nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; nucleotide binding regulatory protein, putative
kinase subunit of RNA polymerase II carboxy-terminal domain kinase I, putative
Similar to S. cerevisiae CTK1; In S. cerevisiae: phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
uncharacterized protein YIL156W-B precursor homologue, putative
glucosamine--fructose-6-phosphate aminotransferase [isomerizing], putative
In S. cerevisiae: catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; glucosamine-6-phosphate synthase, putative; glutamine-fructose-6-phosphate amidotransferase, putative
uncharacterized protein ydr282c homologue, putative
Similar to S. cerevisiae FLO11; In C. albicans; described as a regulator or filamentous growth; In S. cerevisiae: GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth; filamentous growth regulator, putative
Similar to S. cerevisiae ILV2; In S. cerevisiae: catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors
Similar to S. cerevisiae KRI1; In S. cerevisiae: essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p; ribosome biogenesis protein, putative
Similar to S. cerevisiae ALR1; In S. cerevisiae: plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transporter, putative
most of internal region and part of one LTR missing.
Similar to S. cerevisiae COX7; terminal member of the mitochondrial inner membrane electron transport chain
spliced gene; Similar to S. cerevisiae PSH1; RNA polymerase II elongation factor, putative
Similar to S. cerevisiae APL2; In S. cerevisiae: beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; clathrin associated protein complex large subunit, putative
RNA polymerase II mediator complex subunit, putative
Similar to S. cerevisiae MED7; In S. cerevisiae: associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
E3 ubiquitin-protein ligase complex Scf subunit, putative
Similar to S. cerevisiae HRT1; spliced gene; RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF), putative; RING-box protein Hrt1 homologue, putative
spliced gene; Similar to S. cerevisiae PHA2; In S. cerevisiae: catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
cytochrome c peroxidase, mitochondrial precursor, putative
Similar to S. cerevisiae CCP1; In S. cerevisiae: degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
Similar to S. cerevisiae STH1; In S. cerevisiae: ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; chromatin structure-remodeling complex protein, putative; nuclear protein Sth1/Nps1 homologue, putative
presequence translocated-associated motor subunit, mitochondria precursor, putative
Similar to S. cerevisiae PAM17; In S. cerevisiae: required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase
Similar to S. cerevisiae YSY6; function unknown; protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
Similar to S. cerevisiae OXR1; In S. cerevisiae: protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes
protein Dcg1 homologue (function currently unknown), putative
Similar to S. cerevisiae DDC1; In S. cerevisiae: part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
putative zinc metalloproteinase, putative
uncharacterized protein ygl079w homologue, putative
clathrin assembly complex AP-3 adaptin component delta-like subunit, putative
Similar to S. cerevisiae APL5; In S. cerevisiae: functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; delta adaptin-like subunit of the clathrin associated protein complex (AP-3), putative
1-acyl-sn-glycerol-3-phosphate acyltransferase, putative
Similar to S. cerevisiae SLC1; In S. cerevisiae: atalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism
Similar to S. cerevisiae HSP31; probable chaperone protein Hsp31 homologue, putative
uncharacterized protein ygl080w homologue, putative
appears to be a fusion of orf19.254 and orf19.255; Similar to Candida albicans FZC99; possibly fungus-specific
zinc finger-containing protein, putative
potential delta(6)-or delta(8)-desaturase, putative
Similar to S. cerevisiae SEC59; In S. cerevisiae: catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
structural maintenance of chromosomes protein, putative
Similar to S. cerevisiae SMC3; In S. cerevisiae: required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; subunit of the multiprotein Cohesin complex required for sister chromatid cohesion in mitotic cells, putative
uncharacterized protein ydr210w homologue, putative
radiation sensitive protein 28 homologue, putative
Similar to S. cerevisiae RAD28; In S. cerevisiae: involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein
class II aminoacyl-tRNA synthetase, putative
In S. cerevisiae: class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; cytosolic seryl-tRNA synthetase, putative
NADP(+)-dependent dehydrogenase, putative
long-chain fatty acyl-CoA synthetase, putative
Similar to S. cerevisiae FAA2; long-chain-fatty-acyl-CoA ligase, putative
sterol biosynthesis regulatory protein, putative
Similar to S. cerevisiae NSG2; In S. cerevisiae: stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC), putative
Similar to S. cerevisiae TFC4; In S. cerevisiae: one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
Similar to S. cerevisiae POP5; In S. cerevisiae: subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; ribonucleases P/MRP subunit, putative
Similar to S. cerevisiae SLI1; In S. cerevisiae: confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin
thiamine biosynthetic bifunctional enzyme [includes: thiamine-phosphate pyrophosphorylase (ec 2.5.1.3); hydroxyethylthiazole kinase (ec 2.7.1.50)]
Similar to S. cerevisiae THI6; required for thiamine biosynthesis
Similar to Candida albicans MTR1; neutral amino acid transporter, putative
spliced gene; Similar to S. cerevisiae DTD1; In S. cerevisiae: functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
uncharacterized protein Igo2 homologue, putative
autophagy-related E2-like-conjugating enzyme, putative
Similar to S. cerevisiae ATG10; autophagy-related protein, putative
mitochondrial Complex I subunit, putative
methylenetetrahydrofolate reductase, putative
Similar to S. cerevisiae MET13; In S. cerevisiae: catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
killer toxin-resistance protein precursor, putative
Similar to S. cerevisiae KRE5; In S. cerevisiae: required for beta-1,6 glucan biosynthesis
uncharacterized protein yhr134w homologue, putative
Similar to S. cerevisiae WSS1; In S. cerevisiae: suggested role in DNA damage response, processing stalled or collapsed replication forks
Similar to S. cerevisiae DTD1; spliced gene; In S. cerevisiae: functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
Similar to S. cerevisiae ECM14; In S. cerevisiae: required for normal cell wall assembly
D-lactate dehydrogenase [cytochrome] 2, mitochondrial precursor, putative
Similar to S. cerevisiae DLD2; D-lactate ferricytochrome c oxidoreductase, putative
proteophosphoglycan, putative; repetitive cell surface protein, putative
transport protein particle (TRAPP) complex subunit, putative
Similar to S. cerevisiae BET5; In S. cerevisiae: plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
Similar to S. cerevisiae MYO1; In S. cerevisiae: required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring
histone acetyltransferase complex component, putative
Similar to S. cerevisiae HFI1; In S. cerevisiae: adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
nitrosoguanidine resistance protein, putative
mitochondrial protein involved in cell wall biogenesis, putative
Similar to S. cerevisiae ECM18; protein ecm18 (extracellular mutant protein 18) homologue, putative
Similar to S. cerevisiae SSO2; In S. cerevisiae: involved in fusion of secretory vesicles at the plasma membrane
Similar to S. cerevisiae SEC13; In S. cerevisiae: component of both the Nup84 nuclear pore sub-complex and of the COPII complex (important for the formation of ER to Golgi transport vesicles); protein transport protein sec13 homologue, putative
purine nucleoside phosphorylase, putative
Similar to S. cerevisiae PNP1; specifically metabolizes inosine and guanosine nucleosides
Similar to S. cerevisiae CAF17; In S. cerevisiae: interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins
low-affinity methionine permease, putative
aminophospholipid translocase (flippase), putative
Similar to S. cerevisiae DNF2; In S. cerevisiae: localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; phospholipid-transporting ATPase, putative
subunit of mRNA cleavage and polyadenylation factor, putative
Similar to S. cerevisiae CFT2; In S. cerevisiae: required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition
optic atrophy 3 family protein, putative
Similar to S. cerevisiae HTZ1; In S. cerevisiae: histone variant; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; histone HSA.F/Z
Similar to S. cerevisiae NPR2; In S. cerevisiae: possible role in regulating expression of nitrogen permeases
Similar to S. cerevisiae MSL5; In S. cerevisiae: component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; splicing factor, putative
N5-glutamine methyltransferase, putative
Similar to S. cerevisiae MTQ2; In S. cerevisiae: S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro
ubiquitin-like protein with similarity to mammalian NEDD8, putative
Similar to S. cerevisiae CLF1; In S. cerevisiae: may serve as a scaffold during splicesome assembly; spliceosome assembly factor, putative
Similar to S. cerevisiae RAD50; In S. cerevisiae: involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; DNA repair protein, putative
cytosine/purine transport protein, putative
Similar to S. cerevisiae FCY21; purine-cytosine permease, putative
retrotransposon tca3-like polyprotein, putative
nuclear regulatory subunit of serine-threonine phosphatase, putative
Similar to S. cerevisiae SDS22; In S. cerevisiae: conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
adrenodoxin homolog, mitochondrial precursor, putative
Similar to S. cerevisiae YAH1; In S. cerevisiae: required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin; mitochondrial ferredoxin, putative
vesicle transport V-snare protein, putative
spliced gene; Similar to S. cerevisiae VTI1; In S. cerevisiae: involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
mitochondrial external NADH-ubiquinone oxidoreductase precursor, putative
Similar to S. cerevisiae NDE1; In S. cerevisiae: a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
Similar to S. cerevisiae TPO1; In S. cerevisiae: ecognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH
succinate-semialdehyde dehydrogenase, putative
Similar to S. cerevisiae UGA2; In S. cerevisiae: involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways
alanine aminotransferase, mitochondrial precursor, putative
Similar to S. cerevisiae ALT1; glutamic-pyruvic transaminase, putative
beta-glucan synthesis-associated protein, putative
nuclear control of ATPase protein, putative
Similar to S. cerevisiae NCA2; In S. cerevisiae: involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase
uncharacterized protein ypr153w homologue, putative
Similar to S. cerevisiae ULP1; In S. cerevisiae: Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase
Similar to S. cerevisiae JLP1; In S. cerevisiae: involved in sulfonate catabolism for use as a sulfur source
spliced gene; Similar to S. cerevisiae GTT1
subunit of the prohibitin complex, putative
Similar to S. cerevisiae PHB1; In S. cerevisiae: subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
Similar to S. cerevisiae ECM18; in-frame stop codon; apparent frameshift - no splice consensus sequences
pre-rRNA-processing endonuclease, putative
Similar to S. cerevisiae NOB1; In S. cerevisiae: essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentration, putative
Similar to S. cerevisiae TAX4; In S. cerevisiae: together with Irs4p, binds and activates the phosphatase Inp51p
histone deacetylase complex subunit, putative
Similar to S. cerevisiae HDA2; In S. cerevisiae: subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
dihydrosphingosine phosphate lyase, putative
Similar to S. cerevisiae DPL1; In S. cerevisiae: regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases; sphingosine-1-phosphate aldolase, putative; sphingosine-1-phosphate lyase, putative
vacuolar integral membrane protein ydr352w homologue, putative
vacuolar Fe2+/Mn2+ transporter, putative
subunit of the origin recognition complex, putative
Similar to S. cerevisiae ORC3; In S. cerevisiae: subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
acyl-CoA : diacylglycerol acyltransferase
Similar to S. cerevisiae DGA1; In S. cerevisiae: atalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles; diacylglycerol o-acyltransferase, putative
methylthioadenosine phosphorylase, putative
Similar to S. cerevisiae MEU1; In S. cerevisiae: catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
Similar to S. cerevisiae PTR2; In S. cerevisiae: integral membrane peptide transporter, mediates transport of di- and tri-peptides
serine/threonine-protein kinase Rad53 homologue, putative
Similar to S. cerevisiae RAD53; In S. cerevisiae: required for cell-cycle arrest in response to DNA damage
pentamidine resistance factor, mitochondrial precursor, putative
Similar to S. cerevisiae PNT1; In S. cerevisiae: mitochondrial inner membrane protein involved in export of proteins from the mitochondrial matrix; overexpression of PNT1 confers resistance to the anti-Pneumocystis carinii drug pentamidine, and deletion confers increased sensitivity
peptidyl-prolyl cis-trans isomerase PTPA-2, putative
Similar to S. cerevisiae RRD2; In S. cerevisiae: activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; serine/threonine-protein phosphatase 2A activator, putative
cleavage and polyadenylation factor CFI component, putative
Similar to S. cerevisiae CLP1; In S. cerevisiae: involved in both the endonucleolytic cleavage and polyadenylation steps of mRNA 3'-end maturation; subunit of cleavage factor I (CFI), putative
uncharacterized protein yer134c homologue, putative
vacuolar protein sorting protein, putative
Similar to S. cerevisiae PEP8; In S. cerevisiae: essential for endosome-to-Golgi retrograde protein transport
Similar to S. cerevisiae HTB1; In S. cerevisiae: one of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function
Similar to S. cerevisiae HTA1; In S. cerevisiae: one of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function
TAT binding protein-associated factor subunit, putative
Similar to S. cerevisiae TAF11; In S. cerevisiae: involved in RNA polymerase II transcription initiation; transcription initiation factor TFIID subunit, putative
Similar to S. cerevisiae GAP1; general amino-acid permease, putative
zinc cluster transcription factor, putative
Similar to Candida albicans PEX8; peroxisomal matrix protein, putative
coproporphyrinogen III oxidase, putative
Similar to S. cerevisiae HEM13; In S. cerevisiae: an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme; coproporphyrinogenase, putative
subunit of the ubiquinol-cytochrome c reductase complex, putative
spliced gene; Similar to S. cerevisiae QCR6; In S. cerevisiae: component of the mitochondrial inner membrane electron transport chain; required for maturation of cytochrome c1; ubiquinol-cytochrome C reductase hinge protein
nucleolar single-stranded nucleic acid-binding protein, putative
Similar to S. cerevisiae MBP1; In S. cerevisiae: involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
nascent polypeptide-associated complex subunit, putative
Similar to S. cerevisiae EGD2; In S. cerevisiae: alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
cell wall synthesis protein precursor, putative
In C. albicans: required for cell wall beta-1,6-glucan synthesis and is essential for growth on glucose; In S. cerevisiae: glycoprotein involved in cell wall beta-glucan assembly
Similar to S. cerevisiae CAR1; In S. cerevisiae: responsible for arginine degradation
Similar to S. cerevisiae URK1; In S. cerevisiae: uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP; uridine monophosphokinase, putative
Similar to S. cerevisiae PRP2; In S. cerevisiae: RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing
cell wall integrity and stress response component, putative
Similar to S. cerevisiae SLG1; In S. cerevisiae: involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; cell wall integrity factor, putative
spliced gene; Similar to S. cerevisiae BSD2; In S. cerevisiae: heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; regulator of metal ion transport, putative
spliced gene; Similar to S. cerevisiae CTP1; In S. cerevisiae: mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family; tricarboxylate transport protein, putative
subunit of the SWI/SNF chromatin remodelling complex, putative
Similar to S. cerevisiae POL1; In S. cerevisiae: required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; DNA polymerase alpha catalytic subunit A, putative; catalytic subunit of the DNA polymerase I alpha-primase complex, putative
sequence similarity with opaque-phase-specific protein OP4 has been noted, but there has been no conclusive identification of this gene as such
Similar to S. cerevisiae PEP12; In S. cerevisiae: target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin; t-SNARE protein, putative; vacuolar protein sorting-associated protein, putative
Similar to S. cerevisiae SLI1; In S. cerevisiae: potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation; alcohol acetyltransferase, putative
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase, putative
Similar to S. cerevisiae AYR1; In S. cerevisiae: NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones; acylglycerone-phosphate reductase, putative
voltage-gated chloride channel, putative
Similar to S. cerevisiae GEF1; In S. cerevisiae: chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
nucleolar preribosomal-associated protein, putative
Similar to S. cerevisiae URB2; In S. cerevisiae: nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis; ribosome biogenesis protein, putative
Similar to S. cerevisiae SNU13; In S. cerevisiae: RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
vacuolar ATP synthase proteolipid subunit, putative
spliced gene; Similar to S. cerevisiae VMA3; In S. cerevisiae: proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
Similar to S. cerevisiae NUP85; In S. cerevisiae: subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; nucleoporin, putative
ubiquinol-cytochrome c oxidoreductase complex subunit, putative
spliced gene; Similar to S. cerevisiae RIP1; In S. cerevisiae: a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursor, putative
uncharacterized protein yel023c homologue, putative
In S. cerevisiae: expression of this gene is greatly increased during sporulation; spliced gene
uncharacterized protein ymr244w homologue, putative
member of SUN gene family - see Pfam:PF03856
WD repeat protein ybl104c homologue, putative
In S. cerevisiae: protein serine/threonine kinase essential for cell wall remodeling during growth
Similar to S. cerevisiae RAS1; In S. cerevisiae: GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
bud site selection protein rax1 homologue, putative
Similar to S. cerevisiae RAX1; In S. cerevisiae: protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
Similar to S. cerevisiae RPL19B; In S. cerevisiae: RPL19A and RPL19B are nearly identical; spliced gene
uncharacterized protein ybl028c homologue, putative
In S. cerevisiae: predicted to be involved in ribosome biogenesis; localizes to the nucleolus
Similar to S. cerevisiae ADE2; In S. cerevisiae: catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine; phosphoribosylaminoimidazole carboxylase, putative
TEA/ATTS transcription factor involved in regulation of hypha-specific genes, putative
Similar to S. cerevisiae TEC1; In C. albicans: involved in regulation of hypha-specific genes; required for wild-type biofilm formation; transcriptional enhancer activator, putative
Similar to S. cerevisiae NTO1; In S. cerevisiae: subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; histone acetyltransferase complex subunit, putative
calcium/calmodulin-dependent protein kinase II, putative
CAATT-binding protein homologue, putative
Similar to S. cerevisiae MAK21; In S. cerevisiae: constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein; ribosome biogenesis protein, putative
proteolytically activated transcription factor, putative
Similar to S. cerevisiae STP2; In S. cerevisiae: transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; zinc finger protein, putative
RNA-binding RNA annealing protein, putative
Similar to S. cerevisiae YRA1; In S. cerevisiae: Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export; spliced gene; mRNA export protein, putative
In S. cerevisiae: putative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance; spindle pole body interacting protein, putative
Similar to Mus musculus Slc25a17; disagreement in databases whether this is a mitochondrial or a peroxisomal carrier protein; peroxisomal membrane protein, putative
uncharacterized protein ydl237w precursor, putative
Similar to S. cerevisiae ORT1; In S. cerevisiae: ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
Similar to S. cerevisiae RPS15; spliced gene
In S. cerevisiae: a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome
CGD describes this gene as an orthologue of S. cerevisiae RAD50. This is not supported by Fasta/BlastP alignments
Similar to S. cerevisiae NUP42; In S. cerevisiae: subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; subunit of the nuclear pore complex, putative
Similar to S. cerevisiae ARV1; In S. cerevisiae: required for normal intracellular sterol distribution and for sphingolipid metabolism
uncharacterized membrane protein ylr241w homologue, putative
Similar to S. cerevisiae TOP3; In S. cerevisiae: conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
Similar to S. cerevisiae SEN1; In S. cerevisiae: putative helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis; tRNA-splicing endonuclease positive effector, putative
COPii-coated vesicle-associated protein, putative
Similar to S. cerevisiae ERV41; In S. cerevisiae: protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
translation termination inhibitor protein Itt1 homologue, putative
Similar to S. cerevisiae ITT1; In S. cerevisiae: modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro
peroxisomal integral membrane peroxin, putative
Similar to S. cerevisiae PEX28; In S. cerevisiae: peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; peroxisomal membrane protein Pex28p homologue, putative
Similar to S. cerevisiae STM1; In Candida maltosa: homolog of a purine motif triple-helical DNA-binding protein, Stm1p, is a ribosome-associated protein and dissociated from ribosomes prior to the induction of cycloheximide resistance; In S. cerevisiae: binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; spliced gene; purine motif triple-helical DNA-binding protein, putative
guanine nucleotide exchange protein, putative
Similar to S. cerevisiae SEC7; In S. cerevisiae: guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles; protein transport protein Sec7 homologue, putative
fatty acid synthase subunit alpha (ec 2.3.1.86) [includes: acyl carrier; 3-oxoacyl-[acyl-carrier-protein] reductase (ec 1.1.1.100) (beta-ketoacyl reductase); 3-oxoacyl-[acyl-carrier-protein] synthase (ec 2.3.1.41) (beta-ketoacyl synthase)], putative
In S. cerevisiae: catalyzes the synthesis of long-chain saturated fatty acids
zinc finger-containing transcription factor, putative
Similar to S. cerevisiae SFP1; In S. cerevisiae: transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
activator of meiotic anaphase promoting complex (APC/C), putative
Similar to S. cerevisiae AMA1; In S. cerevisiae: activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; spliced gene; sporulation-specific protein, putative
Similar to S. cerevisiae PIN3; In S. cerevisiae: induces appearance of [PIN+] prion when overproduced
multidrug transporter of the ABC transporter family, putative
Similar to S. cerevisiae NOP14; In S. cerevisiae: forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; nucleolar complex protein, putative
Similar to S. cerevisiae NCE102; In S. cerevisiae: involved in secretion of proteins that lack classical secretory signal sequences
proteasome non-aATPase subunit, putative
Similar to S. cerevisiae NAS6; In S. cerevisiae: regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; proteasome regulatory subunit, putative
Similar to S. cerevisiae SNF3; glucose transporter, putative
undecaprenyl pyrophosphate synthetase, putative
Similar to S. cerevisiae NUS1; In S. cerevisiae: required for cell viability; involved in protein trafficking
Similar to S. cerevisiae ARF2; In S. cerevisiae: involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; GTPase of the Ras superfamily, putative
Similar to S. cerevisiae RPL35A/RPL35B; In S. cerevisiae: Rpl35A and Rpl35B proteins are identical; spliced gene
Similar to S. cerevisiae UFD2; In S. cerevisiae: ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; uniquitin chain assembly factor, putative
R3H single-stranded nucleic acid binding protein, putative
Rho GDP-dissociation inhibitor, putative
Similar to S. cerevisiae RDI1; In S. cerevisiae: involved in the localization and regulation of Cdc42p
Similar to S. cerevisiae SRS2; In S. cerevisiae: involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
uncharacterized protein yhr151c homologue, putative
Similar to S. cerevisiae PHB2; In S. cerevisiae: subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
Similar to S. cerevisiae ATG9; In S. cerevisiae: transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; cytoplasm to vacuole targeting protein, putative
zinc-finger transcription factor, putative
Similar to S. cerevisiae ADR1; In S. cerevisiae: carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
3-oxoacyl-[acyl-carrier-protein] synthase, putative
Similar to S. cerevisiae CEM1; In S. cerevisiae: possible role in fatty acid synthesis; required for mitochondrial respiration; beta-keto-acyl synthase, putative
Similar to S. cerevisiae RPL18A/RPL18B; In S. cerevisiae: gene products of RPL18A and RPL18B are identical; spliced gene
uncharacterized membrane protein yol073c homologue, putative
microtubule biogenesis protein, putative
Similar to S. cerevisiae PAC10; In S. cerevisiae: part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding; spliced gene; prefoldin subunit, putative
tRNA guanosine-2'-o-methyltransferase, putative
Similar to S. cerevisiae TRM11; In S. cerevisiae: catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
cleavage and polyadenylation factor CF I component, putative
Similar to S. cerevisiae HRP1; In S. cerevisiae: ubunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; nuclear polyadenylated RNA-binding protein, putative
Similar to S. cerevisiae DBP10; ribosome biogenesis protein, putative
Similar to Candida albicans ZCF33; possibly fungal-specific
Similar to S. cerevisiae RHB1; In S. cerevisiae: putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
Similar to S. cerevisiae MCA1; In S. cerevisiae: putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment; metacaspase precursor, putative
Similar to S. cerevisiae RPS19A/RPS19B; In S. cerevisiae: required for assembly and maturation of pre-40 S particles; nearly identical to Rps19Bp; spliced gene
Similar to S. cerevisiae DYN1; In S. cerevisiae: microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division; microtubule motor protein, putative
short variant of CDR1; this protein exists as a longer form (UniProt Q8NJ55; 1501aa) in C. dubliniensis strain CD57; the truncated version described here (UniProt Q8NJ56; 755aa) is found in strain CD36; see Moran et al. (2002). Antimicrobial Agents and Chemotherapy 46(9): 2829-2941 for further details; the truncated protein expressed by this short variant of the CDR1 gene does not show drug resistance activity
elongation of fatty acids protein, putative
uncharacterized protein yll032c homologue, putative
Similar to S. cerevisiae CKI1; In S. cerevisiae: catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway)
Similar to S. cerevisiae DIE2; dolichyl-phosphoglucose-dependent glucosyltransferase, putative
cell wall assembly regulatory protein, putative
Similar to S. cerevisiae SMI1; In S. cerevisiae: proposed to be involved in coordinating cell cycle progression with cell wall integrity
mitochondrial ATP-dependent protease, putative
Similar to S. cerevisiae PIM1; In S. cerevisiae: involved in intramitochondrial proteolysis; involved in degradation of misfolded proteins in mitochondria; required for bigenesis and maintenance of mitochondria
In S. cerevisiae: protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; implicated in control of filamentation in C. albicans; spliced gene
uncharacterized membrane protein yjl163c homologue, putative
phosphatidylinositol N-acetylglucosaminyltransferase subunit, putative
Similar to S. cerevisiae GPI1; In S. cerevisiae: membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
Similar to S. cerevisiae MAM3; In S. cerevisiae: required for normal mitochondrial morphology
uncharacterized protein ykr051w homologue, putative
uncharacterized protein yjl131c homologue, putative
In S. cerevisiae: detected in highly purified mitochondria in high-throughput studies
vacuolar amino acid transporter, putative
Similar to S. cerevisiae AVT4; In S. cerevisiae: exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
Similar to S. cerevisiae TEA1; fungal specific transcription factor, putative; retrotransposon transcriptional activator, putative
Similar to S. cerevisiae MSB3; In S. cerevisiae: GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization
Similar to S. cerevisiae DNM1; In S. cerevisiae: Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur
dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit precursor, putative
Similar to S. cerevisiae OST1; In S. cerevisiae: Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; homologous to mammalian ribophorin I; oligosaccharyl transferase subunit, putative
Similar to S. cerevisiae CPR5; In S. cerevisiae: peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; peptidyl-prolyl cis-trans isomerase D precursor, putative
multidrug transporter of the major facilitator superfamily, putative
Similar to S. cerevisiae AQR1; In S. cerevisiae: confers resistance to short-chain monocarboxylic acids and quinidine; quinidine/multidrug transporter, putative
branched-chain-amino-acid aminotransferase, cytosolic, putative
Similar to S. cerevisiae JLP1; In S. cerevisiae: Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source
chitin synthase regulatory factor, putative
uncharacterized protein ynl208w homologue, putative
Similar to S. cerevisiae KIP3; In S. cerevisiae: involved in mitotic spindle positioning
Similar to S. cerevisiae LAC1; In S. cerevisiae: involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine
RNA polymerase II holoenzyme cyclin-like subunit, putative
Similar to S. cerevisiae SSN8; In S. cerevisiae: involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
DNA/pantothenate metabolism flavoprotein, putative
phosphopantothenoylcysteine synthetase catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; phosphopantothenoylcysteine synthetase, putative
sorting and assembly machinery (SAM) complex subunit of the mitochondrial outer membrane, putative
Similar to S. cerevisiae SAM50; In S. cerevisiae: essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
Similar to S. cerevisiae CRZ1; In S. cerevisiae: activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
Similar to S. cerevisiae SGF11; spliced gene; subunit of SAGA histone acetyltransferase complex, putative
Similar to S. cerevisiae SEN54; tRNA-splicing endonuclease subunit, putative
Similar to S. cerevisiae KRE6; beta-glucan synthesis-associated protein, putative
flavin-containing monooxygenase, putative
Similar to S. cerevisiae FMO1; In S. cerevisiae: localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins; thiol-specific monooxygenase, putative
Similar to S. cerevisiae FYV10; In S. cerevisiae: protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase
uncharacterized protein yil096c homologue, putative
In S. cerevisiae: known to associate with precursors of the 60S ribosomal subunit
ubiquitin carboxyl-terminal hydrolase, putative
Similar to S. cerevisiae UBP1; In S. cerevisiae: ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains; ubiquitin-specific protease, putative
poly uridylate-binding protein, putative
Similar to S. cerevisiae PUB1; In S. cerevisiae: abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes; poly(A)+ RNA-binding protein, putative
S-adenosylmethionine-dependent methyltransferase, putative
Similar to S. cerevisiae TRM12; In S. cerevisiae: required for wybutosine formation in phenylalanine-accepting tRNA; tRNA wybutosine-synthesizing protein, putative
uncharacterized membrane protein yol092w, putative
heme-responsive zinc finger transcription factor, putative
Similar to S. cerevisiae HAP1; In S. cerevisiae: zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen
oleate-activated transcription factor, putative
Similar to S. cerevisiae OAF1; In S. cerevisiae: activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
U2 small nuclear ribonucleoprotein, putative
Similar to S. cerevisiae MSL1; In S. cerevisiae: U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro
anaphase spindle elongation protein, putative
Similar to S. cerevisiae ASE1; In S. cerevisiae: mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; microtubule-associated protein (MAP) family member, putative
In S. cerevisiae: Sis2p is a negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression; ion homeostasis regulating protein, putative; phosphopantothenoylcysteine decarboxylase, putative; protein phosphatase inhibitor, putative
long-chain-fatty-acyl-CoA synthetase, putative
elongation factor 1 gamma domain-containing protein
Similar to S. cerevisiae CAM1; In S. cerevisiae: homolog of translational cofactor elongation factor-1 gamma, participates in the regulation of GTP-binding protein EF-1 alpha, may play a redundant role in the regulation of protein synthesis or another GTP-dependent process; spliced gene
subunit of Golgi mannosyltransferase complex, putative
In S. cerevisiae: mediates elongation of the polysaccharide mannan backbone
Similar to S. cerevisiae NOG1; In S. cerevisiae: ptative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins; ribosome biogenesis protein, putative
mitochondrial respiratory complex assembly protein, putative
Similar to S. cerevisiae MBA1; In S. cerevisiae: protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane; protein Mba1, mitochondrial precursor, putative
Similar to S. cerevisiae ELP3; In S. cerevisiae: subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; RNA polymerase II Elongator subunit, putative; histone acetyltransferase, putative
Similar to S. cerevisiae PBS2; In S. cerevisiae: plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress
DNA polymerase zeta catalytic subunit, putative
Similar to S. cerevisiae REV3; In S. cerevisiae: involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
initiation-specific alpha-1,6-mannosyltransferase, putative
Similar to S. cerevisiae OCH1; In S. cerevisiae: initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; mannosyltransferase of the cis-Golgi apparatus, putative
ATP-dependent DEAD-box RNA helicase, putative
Similar to S. cerevisiae DED1; In S. cerevisiae: required for translation initiation of all yeast mRNAs
Similar to S. cerevisiae UTR1; In S. cerevisiae: phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)
Similar to S. cerevisiae GDA1; In S. cerevisiae: guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; guanosine-diphosphatase, putative
Similar to S. cerevisiae NSA2; In S. cerevisiae: contributes to processing of the 27S pre-rRNA
U3 small nucleolar ribonucleoprotein protein, putative
Similar to S. cerevisiae LCP5; In S. cerevisiae: essential protein involved in maturation of 18S rRNA; rRNA maturation protein, putative
Similar to S. cerevisiae CPR5; In S. cerevisiae: catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; peptidyl-prolyl cis-trans isomerase precursor, putative
Similar to S. cerevisiae MED6; In S. cerevisiae: subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
dinucleoside triphosphate hydrolase, putative
In S. cerevisiae: ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; thioredoxin peroxidase, putative
Similar to C. dubliniensis ALSD2; agglutinin-like protein, putative; cell-surface glycoprotein, putative
ISWI chromatin-remodeling complex ATPase, putative
Similar to S. cerevisiae ISW2; In S. cerevisiae: member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
disruptor of telomeric silencing protein, putative
Similar to S. cerevisiae DOT1; In S. cerevisiae: nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization; histone-lysine N-methyltransferase, putative
catabolic L-serine/threonine dehydratase [includes: l-serin dehydratase (ec 4.3.1.17) (l-serine deaminase); l-threonin dehydratase (ec 4.3.1.19) (l-threonine deaminase)], putative
Similar to S. cerevisiae CHA1; In S. cerevisiae: catalyzes the degradation of both L-serine and L-threonine
transport vesicle coat component, putative
Similar to S. cerevisiae ERV25; In S. cerevisiae: protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
mitochondrial 54S ribosomal protein YmL39
lysine-specific metalloprotease of the mitochondrial intermembrane space, putative
Similar to S. cerevisiae CYM1; In S. cerevisiae: lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; mitochondrial presequence protease, putative
mitochondrial inner membrane oxaloacetate transporter, putative
Similar to S. cerevisiae OAC1; In S. cerevisiae: transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
Similar to S. cerevisiae MUB1; zinc finger protein, putative
Similar to S. cerevisiae MMS21; In S. cerevisiae: SUMO ligase involved in chromosomal organization and DNA repair
Similar to S. cerevisiae CPR5; In S. cerevisiae: peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; peptidyl-prolyl cis-trans isomerase precursor, putative
Similar to S. cerevisiae LCP5; In S. cerevisiae: essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
uracil-DNA glycosylase, mitochondrial precursor, putative
Similar to S. cerevisiae UNG1; In S. cerevisiae: racil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
oligosaccharyltransferase complex subunit, putative
Similar to S. cerevisiae OST6; In S. cerevisiae: subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
Similar to S. cerevisiae APN1; In S. cerevisiae: major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; DNA-(apurinic or apyrimidinic site) lyase, putative; apurinic-apyrimidinic endonuclease, putative
Similar to S. cerevisiae NUP116; In S. cerevisiae: subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; nucleoporin, putative
glycogen synthesis initiator protein, putative
Similar to S. cerevisiae GLG2; In S. cerevisiae: self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; glycogenin glucosyltransferase, putative
adhesion and aggregation mediating surface antigen, putative
Similar to S. cerevisiae ECM15; spliced gene
truncated LTR, preceded by end of POL ORF and PPT.
galactoside O-acetyltransferase, putative
In S. cerevisiae: required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; expressed only in MATa cells; Ste6p homologue, putative
nuclear envelope integral membrane protein required for nuclear transport, putative
Similar to S. cerevisiae BRR6; In S. cerevisiae: essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores
Similar to S. pombe THP1; G/U mismatch-specific uracil DNA glycosylase, putative; uracil mismatch repair protein, putative
uncharacterized protein yor352w homologue, putative
vacuolar import and degradation protein, putative
Similar to S. cerevisiae VID24; In S. cerevisiae: peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
methylene-fatty-acyl-phospholipid synthase, putative
In S. cerevisiae: catalyzes the last two steps in phosphatidylcholine biosynthesis; unsaturated phospholipid N-methyltransferase, putative
Similar to S. cerevisiae JEN1; In S. cerevisiae: required for uptake of lactate and pyruvate; lactate transporter, putative
saccharopine dehydrogenase [NADP+, L-glutamate-forming], putative
Similar to S. cerevisiae LYS9; In S. cerevisiae: catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway; saccharopine reductase, putative
protein involved in mtDNA inheritance, putative
Similar to S. cerevisiae DML1; In S. cerevisiae: essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes
Similar to S. cerevisiae BNI5; In S. cerevisiae: protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
appears to be a fusion of C. albicans orf19.7452 and orf19.7453; Similar to S. cerevisiae SLD3; In S. cerevisiae: protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
subunit of TFIID and SAGA complexes, putative
Similar to S. cerevisiae TAF6; In S. cerevisiae: subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; transcription initiation factor TFIID subunit, putative
mitochondrial membrane protein, putative
pre-mRNA-processing ATP-dependent RNA helicase, putative
Similar to S. cerevisiae PRP5; In S. cerevisiae: necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
Similar to S. cerevisiae EHD3; In S. cerevisiae: believed to play an indirect role in endocytic membrane trafficking
uncharacterized mitochondrial protein, putative
Similar to S. cerevisiae AEP2; In S. cerevisiae: believed to be involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
Similar to S. cerevisiae SSS1; In S. cerevisiae: subunit of the Sec61p translocation complex that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex
ribosomal RNA-processing protein, putative
Similar to S. cerevisiae RRP1; In S. cerevisiae: essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles; ribosome biogenesis protein, putative
Similar to S. cerevisiae SLU7; In S. cerevisiae: RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing
polysome-associated RNA binding protein, putative
Similar to S. cerevisiae SLF1; In S. cerevisiae: proposed to be involved in regulating mRNA translation
helix-loop-helix DNA binding protein, putative
Similar to S. cerevisiae DCN1; In S. cerevisiae: Defective in Cullin Neddylation protein 1; spliced gene; cullin neddylation protein, putative
anaphase-promoting complex (APC) subunit, putative
Similar to S. cerevisiae APC2; In S. cerevisiae: subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p
Similar to S. cerevisiae TAF12; In S. cerevisiae: involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; transcription initiation factor TFIID subunit, putative
fluconazole resistance protein, putative
In S. cerevisiae: putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; xylose and arabinose reductase, putative
glyceraldehyde-3-phosphate dehydrogenase, putative
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase, putative
Similar to S. cerevisiae PMT2; In S. cerevisiae: transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals; protein O-mannosyltransferase, putative
Similar to S. cerevisiae ISA2; In S. cerevisiae: protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space
protein phosphatase regulatory subunit, putative
Similar to S. cerevisiae TPD3; In S. cerevisiae: required for cell morphogenesis and for transcription by RNA polymerase III
uncharacterized protein ydr089w homologue, putative
signal recognition particle subunit, putative
Similar to S. cerevisiae SRP68; In S. cerevisiae: core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
Similar to S. cerevisiae PFA3; protein fatty acyltransferase, putative
NADH kinase, mitochondrial precursor, putative
general transcriptional co-repressor, putative
Similar to S. cerevisiae CYC8; In S. cerevisiae: also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
Similar to S. cerevisiae YSA1; ADP-ribose pyrophosphatase, putative; adenosine diphosphoribose pyrophosphatase, putative
component of the SAGA histone acetylase complex, putative
Similar to S. cerevisiae SUS1; In S. cerevisiae: involved in mRNA export coupled transcription activation
peptidyl-prolyl cis-trans isomerase, putative
Similar to S. cerevisiae RRD1; In S. cerevisiae: ativator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; phosphotyrosyl phosphatase activator, putative; serine/threonine-protein phosphatase activator, putative
Similar to S. cerevisiae HHT2; In S. cerevisiae: one of two identical histone H3 proteins (see also HHT1 and HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
Similar to S. cerevisiae NAM8; U1 snRNP protein, putative
component of the spindle pole body outer plaque, putative
Similar to S. cerevisiae NUD1; In S. cerevisiae: required for exit from mitosis
Similar to S. cerevisiae ERV14; In S. cerevisiae: protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; spliced gene; coated vesicle protein, putative
Similar to S. cerevisiae MTL1; proteophosphoglycan, putative; sialophosphoprotein, putative
In S. cerevisiae: Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); Rab proteins geranylgeranyltransferase component, putative
bifunctional dehydrogenase/ferrochelatase, putative
Similar to S. cerevisiae MET8; In S. cerevisiae: involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
gamma-glutamyl phosphate reductase, putative
Similar to S. cerevisiae PRO2; In S. cerevisiae: catalyzes the second step in proline biosynthesis; glutamate-5 semialdehyde dehydrogenase, putative
Similar to S. cerevisiae DRS2; In S. cerevisiae: maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; phospholipid-transporting ATPase, putative
eIF-2B guanine-nucleotide exchange factor, putative
Similar to S. cerevisiae GCD2; In S. cerevisiae: delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; translation initiation factor eIF-2B subunit, putative
Similar to S. cerevisiae ECM29; In S. cerevisiae: major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
Similar to S. cerevisiae UBI4; In S. cerevisiae: ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
Similar to S. cerevisiae ENT4; contains an ENTH (Epsin N-Terminal Homology) domain (Pfam: PF01417), found in proteins involved in endocytosis and cytoskeletal machinery, although the function of the domain itself is unknown
uncharacterized protein yhl029c homologue, putative
Similar to S. cerevisiae OCA5; In S. cerevisiae: cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
Similar to S. cerevisiae NOP13; In S. cerevisiae: protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA; nucleolar protein, putative
intracellular protein transport protein, putative
Similar to S. cerevisiae USO1; In S. cerevisiae: essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex; plasma membrane protein, putative
negative regulator of sporulation, putative
appears to be a fusion of orf19.6759 and orf19.6760; In S. cerevisiae: putative negative regulator of early meiotic gene expression
NADP(+)-coupled glycerol dehydrogenase, putative
Similar to S. cerevisiae GCY1; In S. cerevisiae: putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family; aldo-keto reductase, putative
Rab GTPase-interacting protein, putative
Similar to S. cerevisiae YIP4; In S. cerevisiae: protein that interacts with Rab GTPases, localized to late Golgi vesicles; possible role in vesicle-mediated transport; Yip4p homologue, putative
Similar to S. cerevisiae DLD1; In S. cerevisiae: oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane; D-lactate ferricytochrome c oxidoreductase, putative
mitochondrial 37S ribosomal protein RSM10
2'-O-ribose tRNA anticodon loop methyltransferase, putative
Similar to S. cerevisiae TRM7; In S. cerevisiae: 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; tRNA (uridine-2'-O-)-methyltransferase, putative
Similar to S. cerevisiae KRS1; In S. cerevisiae: also identified as a negative regulator of general control of amino acid biosynthesis; lysyl-tRNA synthetase, cytoplasmic, putative
Similar to Homo sapiens EIF3S3; eukaryotic translation initiation factor 3 subunit, putative
uncharacterized protein ymr262w homologue, putative
RNA polymerase II subunit a c-terminal domain phosphatase, putative
Similar to S. cerevisiae FCP1; In S. cerevisiae: carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
Similar to S. cerevisiae PRP19; In S. cerevisiae: splicing factor associated with the spliceosome; pre-mRNA-splicing factor, putative
Similar to Homo sapiens PGM2; phosphoglucomutase, putative
In S. cerevisiae: component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant; spliced gene; vanadate resistance protein, putative
Similar to S. cerevisiae FMP38; In S. cerevisiae: FMP38 - Found in Mitochondrial Proteome, protein 38; non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Similar to S. cerevisiae CYC8; In S. cerevisiae: general transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
putative uncharacterized protein ycr015c homologue, putative
uncharacterized protein ycr016w homologue, putative
TATA binding protein (TBP)-interacting protein, putative
Similar to Mus musculus Cand1; TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription; see Pfam:PF08623; TIP120, putative; cullin-associated NEDD8-dissociated protein, putative
initiator methionine tRNA 2'-O-ribosyl phosphate transferase, putative
Similar to S. cerevisiae RIT1; In S. cerevisiae: 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA; tRNA A64-2'-O-ribosylphosphate transferase, putative
negative regulator of ty transcription, putative
Similar to S. cerevisiae SPT2; In S. cerevisiae: protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins; transcription factor, putative
fumarate hydratase, mitochondrial precursor, putative
Similar to S. cerevisiae FUM1; In S. cerevisiae: converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation
Similar to S. cerevisiae ARC18; In S. cerevisiae: required for the motility and integrity of cortical actin patches
DNA repair protein Rad4 homologue, putative
Similar to S. cerevisiae RAD4; In S. cerevisiae: protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
uncharacterized membrane protein ydr090c homologue, putative
histone transcription regulator, putative
Similar to S. cerevisiae HIR3; In S. cerevisiae: transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly
recombination hotspot binding protein, putative
Similar to S. pombe TSN1; spliced gene; translin, putative
RNA (guanine-N7-) methyltransferase, putative
In S. cerevisiae: methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; RNA cap methyltransferase, putative
uncharacterized protein Sgm1p homologue, putative
Similar to S. cerevisiae SGM1; In S. cerevisiae: protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
Similar to S. cerevisiae GZF3; In S. cerevisiae: GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding
possible role in detoxification of epoxides
microtubule-associated protein, putative
Similar to S. cerevisiae BIK1; In S. cerevisiae: microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170; nuclear fusion protein, putative
Similar to S. cerevisiae NUP159; In S. cerevisiae: subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export; subunit of the nuclear pore complex, putative
Similar to S. cerevisiae STD1; In S. cerevisiae: involved in control of glucose-regulated gene expression
Similar to S. cerevisiae FCF2; In S. cerevisiae: essential nucleolar protein involved in the early steps of 35S rRNA processing
Similar to S. cerevisiae SEC61; In S. cerevisiae: essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
D-fructose-1,6-bisphosphate 1-phosphohydrolase, putative
Similar to S. cerevisiae FBP1; fructose-1,6-bisphosphatase, putative
Similar to S. cerevisiae MCH1; In S. cerevisiae: protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane
mitochondrial import inner membrane translocase subunit, putative
Similar to S. cerevisiae TIM8; In S. cerevisiae: mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins
indigoidine synthase A-like protein, putative
gene contains an Indigoidine_A (Pfam:PF04227) domain; suggested role in carbohydrate metabolism
Similar to S. cerevisiae FMP22; In S. cerevisiae: non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Similar to S. cerevisiae MPG1; In S. cerevisiae: synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure; mannose-1-phosphate guanyltransferase, putative
possible retrotransposon-related protein
retrotransposon:solo LTR, iota L (subtelomeric)
incomplete, apparent frameshifts, no splice consensus sequences; Similar to C. albicans YRF1, (HPR5)