Candida dubliniensis CD36 chromosome 2, complete sequence.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Submitted (28-AUG-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (19-JAN-2009) Gamble J.A., Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to FM992689.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
in-frame stop codons, partial sequence, appears to be degenerate pseudogene; Similar to C. albicans YRF1, (HPR5)
polyprotein of l1-like non-ltr retrotransposon zorro 1 (frameshifted), probable
5' truncated ORF1 + 3' truncated ORF2 (subtelomeric)
U3 small nucleolar ribonucleoprotein protein, putative
involved in 18S rRNA production; Similar to S. cerevisiae MPP10
GPI-anchored cell wall protein, putative
meiosis-specific transcription factor, putative
possible upstream start codon; Similar to S. cerevisiae NDT80
Similar to S. cerevisiae NAT2; N-terminal peptidyl-methionine acetyltransferase, putative
hypothetical mitochondrial outer membrane protein
possible upstream start codon; Similar to S. cerevisiae PRP18
Similar to S. cerevisiae TFG2; transcription initiation factor IIF, beta subunit, putative
arginyl-trna-protein transferase, putative
Similar to S. cerevisiae ATE1; arginyltransferase, putative
Similar to S. cerevisiae TMA10; CGD:involved in ATP biosynthesis
CTP:phosphoethanolamin cytidylyltransferase, putative
spliced gene; Similar to S. cerevisiae MUQ1; ethanolamine-phosphate cytidylyltransferase, putative; phosphorylethanolamine transferase, putative
hypothetical membrane protein, conserved
possible mitochondrial location; may be involved in assembly/maturation of mitochondrial iron-sulfur proteins; Similar to S. cerevisiae JAC1
casein kinase II, regulatory (beta) subunit, putative
histone transcription regulator, putative
aromatic amino acid aminotransferase, putative
pleiotropic drug resistance regulatory protein 6, putative
member of the karyopherin-beta family with possible role in nuclear transport and regulation of pleiotropic drug resistance; Similar to S. cerevisiae PDR6
replication factor-A protein 1, putative
spliced gene; Similar to S. cerevisiae STR3; cystathionine beta-lyase, putative; cysteine lyase, putative
subunit of NADH-ubiquinone oxidoreductase, mitochondrial precursor, putative
Similar to S. cerevisiae DHR1; Similar to S. cerevisiae ECM16; ECM16 is an alias, but is widely used - see SGD entry for YMR128W; DEAH box RN helicase, putative; U3 snoRNP-associated helicase, putative
spliced gene; Similar to S. cerevisiae NYV1; CGD describes this gene as the orthologue of NYV1 (Q12255), but Fasta and Blast alignments suggest it is more similar to SNC2 (P33328); vacuolar v-SNARE, putative
DNA polymerase epsilon subunit D, putative
Similar to S. cerevisiae SAS2; something abou silencing protein 2 homologue, putative
APC/C activator protein CDH1 homologue, putative
Similar to S. cerevisiae POM152; nucleoporin, putative; pore membrane protein, putative
4-alpha-hydroxy-tetrahydropterin dehydratase, putative
pterin carbinolamine dehydratase, putative; pterin-4-alpha-carbinolamine dehydratase, putative
clathrin-associated protein ap-1 complex component, putative
Similar to S. cerevisiae APM2; similar to adaptin medium chain homolog APM2
fungal zinc cluster transcription factor, putative
HAD-superfamily ia hydrolase, reg-2-like, putative
Similar to S. cerevisiae DFG5; endo alpha-1->6-d-mannanase, putative; mannan endo-1,6-alpha-mannosidase precursor, putative
mate family drug/sodium antiporter, putative
choline and nitrogen mustard permease, putative
Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol.; Similar to S. cerevisiae HNM1; choline transport protein, putative
chromatin remodeling complex subunit, putative
vacuolar Nramp iron transporter, putative
ATP synthase J chain, mitochondrial, putative
spliced gene; Similar to S. cerevisiae ATP18; ATPase synthase I subunit, putative
Similar to S. cerevisiae DAL2; allantoicase, putative
secreted cu/zn superoxide dismutase, putative
endonuclease/exonuclease/phosphatase, putative
component of mitochondrial inner membrane m-AAA protease
Similar to S. cerevisiae YTA12; gene name given as RCA1 in UniProt entry' YTA12 in SGD; In S. cerevisiae: mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; also highly conserved in prokaryotes; mitochondrial respiratory chain complexes assembly protein, putative
chromatin remodeling complex component, putative
Similar to S. cerevisiae NPL6; chromatin structure remodeling complex protein, putative; nuclear protein localization factor, putative; fungal-specific (no human or murine homolog)
triglyceride lipase-cholesterol esterase, putative
Similar to S. cerevisiae TGL1; Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes.
3-ketoacyl-coa thiolase, peroxisomal precursor, putative
Similar to S. cerevisiae FOX3; acetyl-coa acyltransferase, putative; beta-ketothiolase, putative; peroxisomal 3-oxoacyl-coa thiolase, putative
phosphatidate cytidylyltransferase, putative
Similar to S. cerevisiae NBP35; Essential nuclear protein, evolutionarily conserved putative ATPase; exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta.
Similar to S. cerevisiae MSS1; In S. cerevisiae: MSS1 is a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase.
chromatin structure remodeling complex protein RSC4, putative
Similar to S. cerevisiae RSC4; In S. cerevisiae: one of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; remodel the structure of chromatin complex subunit 4
Similar to S. cerevisiae TAH18; In S. cerevisiae: protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta.
phenylalanyl-tRNA synthetase alpha subunit, mitochondrial precursor, putative
Similar to S. cerevisiae MSF1; nomenclature conflict: the gene name MSF1 has been used to refer to both YPR047W and YLR168C in S. cerevisiae.; In S. cerevisiae: mitochondrial phenylalanyl-tRNA synthetase alpha subunit is active as a monomer, unlike the cytoplasmic subunit, which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase.
leucine-rich repeat-containing protein, conserved
no apparent homologue in S. cerevisiae; Similar to C. albicans DDD1
GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 2.1199; coord'3,224; predicted TM helix region, aa 21-43
GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 0.12900001; coord=200,201
spliced gene; Similar to S. cerevisiae VPS24; In S. cerevisiae: one of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; vacuolar protein sorting protein 24, putative
predicted TM helix region, aa 46-68; predicted TM helix region, aa 15-34
Similar to S. cerevisiae RFC5; In S. cerevisiae: subunit of heteropentameric Replication Factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; replication factor c subunit 5, putative; replication factor c5, putative
Similar to S. cerevisiae MXR1; In S. cerevisiae: peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan; protein-methionine-s-oxide reductase
Similar to S. cerevisiae UBP9; ubiquitin carboxyl-terminal hydrolase, putative; ubiquitin thioesterase, putative; ubiquitin-specific-processing protease, putative
In C. albicans: putative glucose transporter of the major facilitator superfamily; glucose-induced, expressed at high glucose; upregulated in biofilm; fluconazole-induced; C. albicans glucose transporter family comprises 20 members; 11 probable transmembrane helices predicted for ZZZ0930 by TMHMM2.0 at aa 40-62, 93-115, 125-144, 151-173, 183-205, 218-237, 340-362, 369-391, 411-433, 446-468 and 473-495
mitochondrial 54S ribosomal protein YmL47
diphthamide biosynthesis protein 4, putative
Similar to S. cerevisiae JJJ3; In S. cerevisiae: required for the first step of diphtamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from s-adenosyl-l- methionine to a histidine residue. diphthamide is a post- translational modification of histidine which occurs in elongation factor 2; j protein type 3, putative
DNA-Directed RNA Polymerase I, 49 kDa polypeptide, putative
ergosterol biosynthetic protein 28, putative
4 probable transmembrane helices predicted by TMHMM2.0 at aa 15-33, 53-75, 85-107 and 114-131; Similar to S. cerevisiae ERG28
PKA-R; cAMP-dependent protein kinase regulatory subunit
1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29
mRNA deadenylase and CCR4-NOT complex subunit Not3p, putative
Similar to S. cerevisiae PEX12; In S. cerevisiae: Pex12p is an integral peroxisomal membrane protein required for peroxisome biogenesis and peroxisomal matrix protein import; peroxisome assembly protein 12, putative
methylthioribose-1-phosphate isomerase, putative
sequence similarity to regulatory subunit of eIF2B, see literature refs. in Q06489; In S. cerevisiae: methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; mtr-1-p isomerase, putative; s-methyl-5-thioribose-1-phosphate isomerase, putative
cpf1 genetically-interacting protein 1, putative
Similar to S. cerevisiae VPS54; In S. cerevisiae: component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p; temperature-sensitive clathrin synthetic mutation protein 3, putative; vacuolar protein sorting protein 54, putative
5 probable transmembrane helices predicted by TMHMM2.0 at aa 43-65, 91-113, 138-160, 197-215 and 243-262
Similar to S. cerevisiae REG1; nomenclature conflict: see SGD entry; In S. cerevisiae: the REG1 gene product is the regulatory subunit of the type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes; protein Reg1; protein Srn1; regulatory subunit for type-1 protein phosphatase, putative
spliced gene; Similar to S. cerevisiae HNM1; nomenclature conflict between CGD and corresponding database entry; 9 probable transmembrane helices predicted by TMHMM2.0 at aa 30-52, 73-90, 100-119, 181-203, 239-261, 282-304, 308-330, 342-364 and 379-401
96 kDa nucleoporin-interacting component, putative
Similar to S. cerevisiae NIC96; In S. cerevisiae: component of the nuclear pore complex, required for nuclear pore formation; nuclear pore protein, putative; nucleoporin, putative
2-oxoglutarate-dependent dioxygenase, putative
apparently not present in S. cerevisiae; prolyl 4-hydroxylase alpha subunit, putative
ATP-dependent RNA helicase Chl1, putative
Similar to S. cerevisiae CHL1; In S. cerevisiae: conserved nuclear protein required to establish sister-chromatid pairing during S-phase.
catabolic L-serine/threonine dehydratase [includes: l-serine dehydratase (ec 4.3.1.17) (l-serine deaminase); l-threonine dehydratase (ec 4.3.1.19) (l-threonine deaminase)], putative
Similar to S. cerevisiae TTP1; nomenclature conflict: described as MNN2 in SGD, TTP1 in UniProt; In S. cerevisiae: an alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides; localizes to an early Golgi compartment.; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 13-30; mannan synthesis protein mnn2, putative; protein ttp1, putative
Similar to S. cerevisiae SNX41; In S. cerevisiae: Sorting Nexin 41 is involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; forms a complex with Snx4p and Atg20p.
26s proteasome regulatory subunit rpn9, putative
Similar to S. cerevisiae RPN9; proteasome non-ATPase subunit 7, putative
NAD-dependent histone deacetylase Sir2, putative
regulatory protein sir2, putative; silent information regulator 2, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.997, signal anchor probability 0.001) with cleavage site probability 0.484 between residues 17 and 18; 7 probable transmembrane helices predicted for ZZZ1130 by TMHMM2.0 at aa 188-210, 223-245, 260-282, 303-322, 342-364, 385-407 and 427-449; Similar to S. cerevisiae PTM1; In S. cerevisiae: protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; possible mannosyltransferase activity; see Q1WMR4; transmembrane protein, putative
Similar to S. cerevisiae SNX4; In S. cerevisiae: sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport.; In C. albicans: protein induced during the mating process; cytoplasm to vacuole targeting protein, putative; sorting nexin, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.952, signal anchor probability 0.003) with cleavage site probability 0.801 between residues 18 and 19; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 429-451; GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 0.442 near 425; Similar to S. cerevisiae DCW1; fungal-specific; In S. cerevisiae: putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation; endo-alpha-->6-D-mannanase, putative; mannan endo-1,6-alpha-mannosidase, precursor, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 1.000, signal anchor probability 0.000) with cleavage site probability 0.661 between residues 17 and 18; GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 0.15599999 near 663; Similar to S. cerevisiae PLB3; In S. cerevisiae: phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; phospholipase B, putative
Similar to S. cerevisiae ENT2; In S. cerevisiae: Epsin-like protein required for endocytosis and actin patch assembly; contains clathrin-binding motif at C-terminus; epsin-like clathrin-binding protein, putative; ubiquitin-interacting protein, putative
Similar to S. cerevisiae RTT107; In S. cerevisiae: Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition.; In C. albicans: protein similar to S. cerevisiae Esc4p, which represses transposition; transposon mutation affects filamentous growth; cell cycle checkpoint protein, putative; regulator of ty1 transposition protein, putative
In C. albicans: B-type mitotic cyclin (cyclin-dependent protein kinase regulatory subunit); essential; required for wild-type mitotic exit; role in cell polarization; interacts with catalytic subunit Cdk1p.; In S. cerevisiae: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome.
2 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29 and 77-94; Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.839, signal anchor probability 0.094) with cleavage site probability 0.586 between residues 19 and 20; possibly C. dubliniensis-specific
adenine phosphoribosyltransferase, putative
Similar to S. cerevisiae APT1; In S. cerevisiae: adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis.; nomenclature conflict: APT1 has been used to refer to APT1/YML022W, which encodes adenine phosphoribosyltransferase, and YLR118C, which encodes acyl-protein thioesterase (info. from SGD)
dynein light chain 1, cytoplasmic, putative
spliced gene; Similar to S. cerevisiae DYN2
Similar to Myrothecium verrucaria CAH; fungal-specific; metal dependent phosphohydrolase, putative; urea hydro-lyase, putative
Similar to S. cerevisiae SSN2; In S. cerevisiae: protein required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; subunit of the RNA polymerase II mediator complex; essential for transcriptional regulation; suppressor of RNA polymerase B, putative
Similar to S. cerevisiae SPT5; In S. cerevisiae: protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing.; In C. albicans: protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growth; transcription elongation factor, putative
Similar to S. cerevisiae SSL1; In S. cerevisiae: component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; general transcription and DNA repair factor IIH subunit, putative; suppressor of stem-loop protein 1, putative
tRNA-specific adenosine deaminase subunit, putative
Similar to S. cerevisiae TAD2; In S. cerevisiae: subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNA; tRNA-specific adenosine-34 deaminase subunit, putative
protein phosphatase methylesterase, putative
NAD(+) synthase (glutamine-hydrolyzing), putative
Similar to S. cerevisiae QNS1; In S. cerevisiae: glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide; glutamine-dependent NAD(+) synthetase, putative
alpha-ketoglutarate-dependent sulfonate dioxygenase, putative
Similar to S. cerevisiae JLP1; functional similarity noted with S. cerevisiae JLP1 (YLL057C): Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein); dioxygenase; putative; sulfonate dioxygenase, putative
Mg2+-dependent phosphatidate phosphatase, putative
Similar to S. cerevisiae SMP2; Similar to S. cerevisiae PAH1; PAH1 is given as the standard name in SGD, but SMP2 appears to be the most widely used name.; In S. cerevisiae: Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1.; additional function referred to in literature: involved in plasmid maintenance and respiration in Saccharomyces cerevisiae (see SGD entry); Phosphatidic acid phosphohydrolase; lipin homolog, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 12-34
Similar to S. cerevisiae PAA1; member of GNAT family of histone transferases; In S. cerevisiae: polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; acetyltransferase, putative; arylalkylamine N-acetyltransferase homolog, putative
Oligoribonuclease, mitochondrial precursor, putative
Similar to S. cerevisiae REX2; In S. cerevisiae: RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; exonuclease, putative
Cytochrome c oxidase polypeptide VIa, mitochondrial precursor, putative
Similar to S. cerevisiae COX13; In S. cerevisiae: subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP.
cell division control protein 55, putative
Similar to S. cerevisiae CDC55; In S. cerevisiae: non-essential regulatory subunit B of protein phosphatase 2A; has multiple roles in mitosis and protein biosynthesis; found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells); protein phosphatase PP2A regulatory subunit B, putative
cytochrome c oxidase polypeptide IV, mitochondrial precursor, putative
Similar to S. cerevisiae COX4; In S. cerevisiae: subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain.
cytoskeleton assembly control protein, putative
Similar to S. cerevisiae SLA1; reported to be fungal specific (CGD); In S. cerevisiae: cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis.
n6-adenosine-methyltransferase, putative
Similar to S. cerevisiae IME4; In S. cerevisiae: probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells.
endoplasmic reticulum membrane protein, putative
4 probable transmembrane helices predicted by TMHMM2.0 at aa 25-47, 69-91, 112-129 and 144-166; Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.002, signal anchor probability 0.646) with cleavage site probability 0.001 between residues 42 and 43
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit, putative
12 probable transmembrane helices predicted by TMHMM2.0 at aa 21-40, 89-111, 124-144, 154-173, 180-202, 217-239, 252-271, 276-295, 307-329, 366-388, 395-417 and 475-497; Similar to S. cerevisiae STT3; In S. cerevisiae: subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; oligosaccharyl transferase subunit, putative
phosphatidylinositol-3-phosphate-binding protein, putative
Similar to S. cerevisiae PIB2; In S. cerevisiae: involved in telomere-proximal repression of gene expression; zinc finger-containing protein, putative
succinate dehydrogenase cytochrome b subunit, mitochondrial precursor, putative
3 probable transmembrane helices predicted for ZZZ1490 by TMHMM2.0 at aa 78-100, 110-132 and 153-175
mitochondrial 54S ribosomal protein YmL31
hypothetical integral membrane protein, conserved
4 probable transmembrane helices predicted by TMHMM2.0 at aa 70-89, 119-141, 162-184 and 199-221
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.966, signal anchor probability 0.009) with cleavage site probability 0.496 between residues 21 and 22; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 1246-1268; Similar to S. cerevisiae MSB2; In S. cerevisiae: mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate; integral membrane protein, putative; mucin family member, putative
Similar to S. cerevisiae PRP39; In S. cerevisiae: U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats; pre-mRNA-processing protein, putative; spliceosomal U1 snRNP protein, putative
Similar to S. cerevisiae RAD7; In C. albicans: protein similar to S. cerevisiae Rad7p, which is a subunit of the Nucleotide Excision Repair Factor 4; induced under hydroxyurea treatment.; In S. cerevisiae: protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4).
spliced gene; Similar to S. cerevisiae RAD23; In S. cerevisiae: protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins.
haloacid dehalogenase-like hydrolase, putative
Similar to S. cerevisiae UTR4; In S. cerevisiae: function unknown, but found in both cytoplasm and nucleus.
transcriptional regulatory protein, putative
orf19.1496 and orf19.1497 map to a single CDS feature in C. dubliniensis; 2 probable transmembrane helices predicted by TMHMM2.0 at aa 625-647 and 700-719; member of the Gal4p family of zinc cluster proteins; Similar to S. cerevisiae ASG1; Similar to C. albicans ZCF6; nomenclature conflict: different names in CGD (orf19.1497; ZCF6) and SGD (YIL130W; ASG1)
Similar to S. cerevisiae ASG1; Similar to C. albicans CTF1; nomenclature conflict: different names in CGD (orf19.1499; CTF1) and SGD (YIL130W; ASG1)
1 probable transmembrane helix predicted by TMHMM2.0 at aa 204-226; no human or murine homologue; Similar to S. cerevisiae TGL5; patatin-like phospholipase, fungal-specific, putative
negative regulator of exit from mitosis, putative
Similar to S. cerevisiae AMN1; In S. cerevisiae: protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN).
Similar to S. cerevisiae ROD1; arrestin proteins are involved in uncoupling G protein-coupled receptors (Gpcr) from heterotrimeric G-proteins; In C. albicans: protein not essential for viability; similar to S. cerevisiae Rod1p, which is a membrane protein with a role in drug tolerance.
4 probable transmembrane helices predicted by TMHMM2.0 at aa 10-32, 91-113, 123-145 and 152-174; In S. cerevisiae: GFP fusion protein localizes to vacuole and cell periphery
phosphatidylinositol 3,5-kinase, putative
phosphatidylinositol-3-phosphate 5-kinase; type III PIP kinase
Similar to S. cerevisiae VPS74; In S. cerevisiae: non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus; vacuolar sorting-associated protein, putative
In C. albicans: putative chitinase similar to S. cerevisiae Cts2p, which is described as a sporulation-specific chitinase; homozygous null mutation causes no obvious defects; transcription decreases upon yeast-to-hyphal switch; glycosyl hydrolase, putative; sporulation-specific chitinase, putative
Similar to S. cerevisiae UBP14; In S. cerevisiae: a ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; glucose-induced degradation protein 6, putative; ubiquitin carboxyl-terminal hydrolase 14, putative; ubiquitin thioesterase 14, putative; ubiquitin-specific-processing protease 14, putative
3-deoxy-d-arabino-heptulosonate 7-phosphate synthase, putative
Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms (see PUBMED:8760910); dahp synthetase, putative; phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited, putative; phospho-2-keto-3-deoxyheptonate aldolase, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 269-291
Similar to S. cerevisiae SPR3; In S. cerevisiae: sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; septin, putative; sporulation-regulated protein, putative
nonsense-mediated decay protein, putative
Similar to S. cerevisiae NMD4; In S. cerevisiae: protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway.
Similar to S. cerevisiae SNF2; In S. cerevisiae: catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p.; In C. albicans: protein involved in transcriptional regulation; ortholog of S. cerevisiae Snf2p, which is the catalytic subunit of the SWI/SNF chromatin remodeling complex; interacts with Swi1p; SWI/SNF complex is essential for hyphal growth and virulence; SWI/SNF chromatin remodelling complex protein, putative; SWI/SNF complex component, putative; transcription regulatory protein, putative
mitochondrial replication protein, putative
Similar to S. cerevisiae MTF1; In S. cerevisiae: mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p; mitochondrial transcription factor, putative; mitochondrial-specificity factor, putative; ribosomal RNA adenine dimethylase, putative
this CDS appears as two separate CDS features in C. albicans; 3 probable transmembrane helices predicted by TMHMM2.0 at aa 270-292, 305-327 and 342-361
mRNA 3'-end-processing protein, putative
Similar to S. cerevisiae RNA14; In S. cerevisiae: cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex.
mitochondrial outer membrane protein, putative
Similar to S. cerevisiae SAM37; In S. cerevisiae: component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex; sorting assembly machinery (SAM) complex subunit, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.997, signal anchor probability 0.000) with cleavage site probability 0.565 between residues 18 and 19; 1 probable transmembrane helix predicted for ZZZ1900 by TMHMM2.0 at aa 399-421
vacuolar membrane zinc transporter, putative
7 probable transmembrane helices predicted by TMHMM2.0 at aa 15-37, 57-79, 127-149, 510-532, 547-569, 593-615 and 625-643; Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.013, signal anchor probability 0.983) with cleavage site probability 0.003 between residues 25 and 26; In S. cerevisiae: vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency.; In C. albicans: protein similar to S. cerevisiae Zrt3p, which is a transporter of zinc ions; predicted Kex2p substrate; zinc transport protein, putative
zinc/cadmium resistance protein, putative
6 probable transmembrane helices predicted by TMHMM2.0 at aa 7-29, 33-55, 76-98, 113-132, 305-327 and 337-359; Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.694, signal anchor probability 0.147) with cleavage site probability 0.500 between residues 26 and 27; Similar to S. cerevisiae ZRC1; In S. cerevisiae: vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm.; this protein apparently represented in two separate UniProt entries: P20107 (zinc/cadmium resistance protein) and Q06808 (oxidative stress resistance); sequences essentially identical, so probably represents the same gene
1 probable transmembrane helix predicted by TMHMM2.0 at aa 345-362; Similar to S. cerevisiae TLG2; In S. cerevisiae: syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; t-SNARE, putative
hexose metabolism-related protein, putative
Similar to S. cerevisiae HEX3; In S. cerevisiae: protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability.; In C. albicans: protein similar to S. cerevisiae Hex3p, which is involved in DNA damage response; transposon mutation affects filamentous growth.
negative regulator of phospholipid biosynthesis, putative
Similar to S. cerevisiae OPI1; In S. cerevisiae: transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance.; In C. albicans: functional homolog of S. cerevisiae Opi1p, which is a transcriptional repressor of INO1 involved in inositol biosynthesis; has leucine zipper and putative Opi1-Sin3 interaction domain; interacts with ScSin3p, but not CaSin3p; overproducer of inositol, putative; transcription factor, putative; transcriptional repressor, putative
Similar to S. cerevisiae RRP5; In S. cerevisiae: protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome.
GATA zinc finger-containing transcription factor, putative
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, putative
Similar to S. cerevisiae PRS3; In S. cerevisiae: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of a five related enzymes, which are active as heteromultimeric complexes.; In C. albicans: phosphoribosylpyrophosphate synthetase; enzyme of purine, pyrimidine, histidine, and tryptophan biosynthesis; essential; flucytosine induced; macrophage/pseudohyphal-induced; phosphoribosyl pyrophosphate synthetase, putative; ribose-phosphate pyrophosphokinase, putative
Similar to S. cerevisiae TAF7; In S. cerevisiae: TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation; transcription initiation factor TFIID subunit 7, putative
spliced gene; Similar to S. cerevisiae ADY2; In S. cerevisiae: required for normal sporulation.
2,3-epoxysqualene-lanosterol cyclase, putative
In C. albicans: 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), catalyzes the conversion of 2,3-oxidosqualene to lanosterol in sterol biosynthesis; fluconazole-induced.; In S. cerevisiae: lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; lanosterol synthase, putative; oxidosqualene-lanosterol cyclase, putative
nucleolar RNA-associated proteins, putative
Similar to S. cerevisiae UTP22; In S. cerevisiae: possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; nucleolar protein UTP22, putative
Rab guanyl-nucleotide exchange factor, putative
Similar to S. cerevisiae VAM6; In S. cerevisiae: vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p; vacuolar assembly protein, putative; vacuolar morphogenesis protein, putative
Similar to S. cerevisiae UTP21; In S. cerevisiae: possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; WD repeat protein, putative
endoplasmic reticulum transmembrane protein, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.976, signal anchor probability 0.002) with cleavage site probability 0.913 between residues 23 and 24; 3 probable transmembrane helices predicted by TMHMM2.0 at aa 7-26, 46-63 and 107-129; Similar to S. cerevisiae YET3
10 probable transmembrane helices predicted for ZZZ2160 by TMHMM2.0 at aa 10-32, 51-68, 78-100, 107-126, 146-168, 367-389, 404-426, 446-468, 483-503 and 516-538; Similar to S. cerevisiae ECM3; membrane transport protein, putative
Similar to S. cerevisiae POB3; In S. cerevisiae: subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; FACT complex subunit, putative; facilitates chromatin transcription complex subunit, putative
aspartate-semialdehyde dehydrogenase, putative
Similar to S. cerevisiae HOM2; In S. cerevisiae: aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis;fungal-specific (no human or murine homolog); ketoconazole-repressed.
leucine permease transcriptional regulator, putative
Similar to S. cerevisiae SAC3; In S. cerevisiae: nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus.
spliced gene; Similar to S. cerevisiae ENT3; In S. cerevisiae: protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p.
Similar to S. cerevisiae CPR3; In S. cerevisiae: mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria; PPIase, putative; cyclophilin C, putative; peptidyl-prolyl cis-trans isomerase C, mitochondrial precursor, putative; rotamase, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 137-156
U4/U6.U5 small nuclear ribonucleoprotein component, putative
Similar to S. cerevisiae SNU23; In S. cerevisiae: component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome.
Similar to S. cerevisiae TPP1; In S. cerevisiae: DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily; DNA 3' phosphatase, putative; polynucleotide 3'-phosphatase, putative; three prime phosphatase, putative
hypothetical mitochondrial protein, conserved
1 probable transmembrane helix predicted by TMHMM2.0 at aa 57-76; function unknown; localized to mitochondrion in S. cerevisiae
mitochondrial 37S ribosomal protein MRPS8
ion transporter of major facilitator superfamily, putative
spliced gene; Similar to S. cerevisiae HOL1; In S. cerevisiae: putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake.; merged with adjacent CDS (Cd36_17340)
polyprotein of L1-like non-LTR retrotransposon
12 probable transmembrane helices predicted for ZZZ2340 by TMHMM2.0 at aa 105-127, 147-166, 178-200, 204-226, 231-253, 263-282, 322-344, 359-378, 385-404, 409-431, 448-470 and 480-502; Similar to S. cerevisiae MCH4; In S. cerevisiae: protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport.
low-affinity zinc transport protein, putative
7 probable transmembrane helices predicted for ZZZ2350 by TMHMM2.0 at aa 29-51, 63-85, 105-127, 212-234, 273-295, 307-329 and 349-366; Similar to S. cerevisiae ZRT2; In C. albicans: protein described as predicted zinc transporter; ciclopirox olamine, fluconazole, or alkaline downregulated; transcriptionally induced by interaction with macrophage; amphotericin B induced.; In S. cerevisiae: low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor; zinc-regulated transporter, putative
phosphatidylinositol-specific phospholipase c, putative
In C. albicans: putative phosphatidylinositol-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; no S. cerevisiae ortholog; role in, and regulated by, filamentation; no mouse systemic virulence role; almost identical to orf19.5797.
glucose transporter of the major facilitator superfamily, putative
11 probable transmembrane helices predicted for ZZZ2370 by TMHMM2.0 at aa 20-37, 81-103, 115-137, 174-196, 203-222, 306-328, 341-363, 373-392, 399-421, 436-458 and 465-487; In C. albicans: putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; regulated by Nrg1p.
RNA polymerase I-specific transcription initiation factor, putative
Similar to S. cerevisiae RRN7; In S. cerevisiae: protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein.
Similar to S. cerevisiae BNA3; In S. cerevisiae: arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate; arylformamidase, putative; biosynthesis of nicotinic acid (BNA) protein, putative
Similar to S. cerevisiae MET1; In S. cerevisiae: S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in sulfate assimilation, methionine metabolism, and siroheme biosynthesis; UROM, putative; urogen III methylase, putative; uroporphyrin-III c-methyltransferase, putative; uroporphyrinogen III methylase, putative
Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.000, signal anchor probability 0.877) with cleavage site probability 0.000 between residues 17 and 18; 2 probable transmembrane helices predicted by TMHMM2.0 at aa 26-48 and 82-104
dihydroxyacetone phosphate acyltransferase, putative
Similar to S. cerevisiae GPT2; In S. cerevisiae: glycerol-3-phosphate acyltransferase located in both lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone, which are intermediate steps in lipid biosynthesis.; 4 probable transmembrane helices predicted by TMHMM2.0 at aa 38-60, 455-474, 507-529 and 539-561; glycerol-3-phosphate o-acyltransferase, putative; glycerol-3-phosphate/dihydroxyacetone phosphate acyltransferase, putative
Similar to S. cerevisiae OYE2; In S. cerevisiae: widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN).
spliced gene; Similar to S. cerevisiae BET3; In S. cerevisiae: hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex; Transport Protein Particle subunit, putative
Similar to S. cerevisiae SUR2; In C. albicans: described as similar to ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions.; In S. cerevisiae: sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosynthesis.; 2 probable transmembrane helices predicted by TMHMM2.0 at aa 30-52 and 136-158
Similar to S. cerevisiae UGA4; In S. cerevisiae: permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane.; 11 probable transmembrane helices predicted by TMHMM2.0 at aa 55-77, 87-109, 141-163, 178-195, 207-229, 286-308, 337-359, 388-410, 417-439, 459-478 and 490-512; GABA-specific transport protein, putative
small glutamine-rich tetratricopeptide repeat-containing protein, putative
Similar to S. cerevisiae SGT2; In C. albicans: protein abundance is affected by URA3 expression in the CAI-4 strain background; transcription is regulated by Mig1p.; In S. cerevisiae: glutamine-rich cytoplasmic protein of unknown function; contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions; has similarity to human SGT, which is a cochaperone that negatively regulates Hsp70.
Similar to S. cerevisiae NCB2; In S. cerevisiae: beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2); transcriptional repressor, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.730, signal anchor probability 0.157) with cleavage site probability 0.384 between residues 22 and 23; 2 probable transmembrane helices predicted for ZZZ2570 by TMHMM2.0 at aa 2-21 and 76-95; GPI-Anchor Signal predicted for ZZZ2570 by DGPI v2.04 with cleavage site probability 0.52 near 59; Similar to S. cerevisiae YOS1; In S. cerevisiae: integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p; integral membrane protein required for ER to Golgi transport, putative
12 probable transmembrane helices predicted by TMHMM2.0 at aa 55-77, 87-109, 141-163, 178-195, 202-224, 246-265, 286-308, 338-360, 391-413, 418-440, 452-474 and 489-511; Similar to S. cerevisiae UGA4; gaba-specific transport protein, putative
cell cycle arrest protein bub2, putative
Similar to S. cerevisiae BUB2; Similar to S. pombe CDC16; In S. cerevisiae: mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage.; In S. Pombe: required both for maintenance of p34cdc2 kinase activity and regulation of septum formation; cell division control protein, putative; mitotic check point protein bub2, putative
splicing factor U2AF. large subunit, putative
heat shock protein 70 homolog LHS1 precursor, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.614, signal anchor probability 0.370) with cleavage site probability 0.398 between residues 20 and 21; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-24; Similar to S. cerevisiae LHS1; In S. cerevisiae: molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway.
xanthine phosphoribosyltransferase, putative
Similar to S. cerevisiae XPT1; In S. cerevisiae: dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate.
ubiquitin fusion degradation protein, putative
Similar to S. cerevisiae UFD1; In S. cerevisiae: protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol.
Signal peptide predicted for ZZZ2650 by SignalP 2.0 HMM (Signal peptide probability 0.719, signal anchor probability 0.000) with cleavage site probability 0.315 between residues 15 and 16; Similar to S. cerevisiae SXM1; In S. cerevisiae: nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; nuclear transport factor, putative
ribosomal rna-processing protein, putative
Similar to S. cerevisiae RRP7; In S. cerevisiae: essential protein involved in rRNA processing and ribosome biogenesis.
4-amino-4-deoxychorismate lyase, putative
In S. cerevisiae: catalyzes the third step in para-aminobenzoic acid biosynthesis.
o-phosphoserine phosphohydrolase, putative
Similar to S. cerevisiae SER2; In S. cerevisiae: phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source; phosphoserine phosphatase, putative
phosphatidylinositol transfer protein, putative
Similar to S. cerevisiae PDR16; In S. cerevisiae: phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p; pleiotropic drug resistance protein, putative; sec14 homolog
Similar to S. cerevisiae BNA3; biosynthesis of nicotinic acid protein 3, putative
S-adenosylmethionine-dependent methyltransferase, putative
described as 'uncharacterized' in UniProt and SGD
aldehyde dehydrogenase, mitochondrial precursor, putative
Similar to S. cerevisiae ALD5; In S. cerevisiae: mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation.
d-lactate dehydrogenase [cytochrome] 1, putative
Similar to S. cerevisiae DLD1; Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.004, signal anchor probability 0.995) with cleavage site probability 0.002 between residues 45 and 46; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 31-50; d-lactate ferricytochrome c oxidoreductase, putative
Similar to Rattus norvegicus OPLAH; 5-oxo-l-prolinase, putative; 5-opase, putative; pyroglutamase, putative
uncharacterized metal-binding protein, putative
ribonucleoside-diphosphate reductase small chain 1, putative
Similar to S. cerevisiae RNR2; In S. cerevisiae: ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; ribonucleotide reductase r2 subunit 1, putative; ribonucleotide reductase small subunit 1, putative
uncharacterized protein Skg3p homologue, putative
Similar to S. cerevisiae SKG3; phenotype observed in S. cerevisiae (SGD:YLR187W)
previously known as CDC9 in C. albicans; changed to LIG4 in assembly 19; polydeoxyribonucleotide synthase [atp], putative
no apparent orthologue in S. cerevisiae; role in, and regulated by, filamentation (info from CDB)
mitochondrial distribution and morphology protein 33, putative
Similar to S. cerevisiae SHE9; 2 probable transmembrane helices predicted by TMHMM2.0 at aa 421-443 and 533-555; mitochondrial inner membrane protein precursor, putative; sensitive to high expression protein 9, mitochondrial precursor, putative
26s protease regulatory subunit 6b homolog, putative
Similar to S. cerevisiae RPT3; tat-binding homolog 2, putative
isocitrate dehydrogenase [nad] subunit 2, mitochondrial precursor, putative
Similar to S. cerevisiae IDH2; isocitric dehydrogenase, putative
5'-phosphoribosylglycinamide transformylase, putative
Similar to S. cerevisiae ADE8; phosphoribosylglycinamide formyltransferase, putative
Similar to S. cerevisiae EFT2; eukaryotic elongation factor 2, putative; ribosomal translocase, putative; translation elongation factor 2, putative
hypothetical transmembrane protein, conserved
6 probable transmembrane helices predicted by TMHMM2.0 at aa 35-54, 64-81, 88-110, 130-149, 156-178 and 250-272
unknown EC_number=1.4.3.6; Similar to Pichia angusta AMO; peroxisomal copper amine oxidase, putative
phospholipase, mitochondrial precursor, putative
6 probable transmembrane helices predicted by TMHMM2.0 at aa 88-110, 297-319, 394-411, 431-450, 463-485 and 505-527
ribonucleoside-diphosphate reductase large chain 1, putative
Similar to S. cerevisiae RNR1; ribonucleotide reductase large subunit 1, putative; ribonucleotide reductase r1 subunit 1, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 9-31
e3 ubiquitin protein ligase tom1, putative
Similar to S. cerevisiae TOM1; suppressor of snRNA protein, putative; temperature-dependent organization in mitotic nucleus protein 1, putative
Similar to S. cerevisiae PRP3; u4/u6 small nuclear ribonucleoprotein prp3, putative
ATP synthase K chain, mitochondrial, putative
spliced gene; Similar to S. cerevisiae ATP19; has not so far been reported in C. albicans
zinc finger-containing transcription factor, putative
elongation of fatty acids protein 2, putative
Similar to S. cerevisiae ELO2; 7 probable transmembrane helices predicted by TMHMM2.0 at aa 53-75, 88-110, 130-152, 157-179, 184-203, 224-241 and 256-278; gns1 protein, putative; v-snare bypass mutant gene 2 protein, putative
rho1 gdp-gtp exchange protein 2, putative
vacuolar amino acid transporter, putative
Similar to S. cerevisiae GPM1; phosphoglyceromutase 1, putative
Similar to S. cerevisiae NSP1; nucleoporin, putative; nucleoskeletal-like protein, putative
mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15), putative
delta-aminolevulinic acid dehydratase, putative
Similar to S. cerevisiae HEM2; porphobilinogen synthase, putative
amino acid sensor-independent protein, putative
Similar to S. cerevisiae VPS20; charged multivesicular body protein, putative; vacuolar protein sorting protein, putative
histidine kinase osmosensor and regulator, putative
mitogen-activated protein kinase hog1, putative
reduced growth phenotype protein (protein rgp1), putative
hypothetical GPI-anchored protein, conserved
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.998, signal anchor probability 0.001) with cleavage site probability 0.907 between residues 19 and 20; GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 0.696 near 531
Similar to S. cerevisiae AMD1; myoadenylate deaminase, putative
Similar to S. cerevisiae THI20; phosphomethylpyrimidine kinase, putative
Similar to S. cerevisiae PAN1; In S. cerevisiae: part of actin cytoskeleton-regulatory complex.
heat shock protein 78, mitochondrial precursor, putative
5 probable transmembrane helices predicted by TMHMM2.0 at aa 74-96, 106-125, 155-172, 182-204 and 233-250; other allele appears to be a pseudogene; Similar to S. cerevisiae DFG16; DFG stands for Defective for Filamentous Growth; Protein of the Rim101p pathway that regulates filamentation in response to alkaline pH; similar to S. cerevisiae Dfg16p (predicted transmembrane receptor, possibly G-protein-coupled) that acts in Rim101p processing. In S. cerevisiae, probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p; protein dfg16, putative; zinc-regulated gene 11 protein, putative
Similar to S. cerevisiae SFB3; In S. cerevisiae: member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate; sec24-related protein 3, putative; sed5-binding protein 3, putative
chromatin modification-related protein, putative
Similar to S. cerevisiae YNG2; In S. cerevisiae: subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1.
3 probable transmembrane helices predicted by TMHMM2.0 at aa 3-25, 35-57 and 235-257
cytochrome c oxidase polypeptide VI, mitochondrial precursor, putative
spliced gene; Similar to S. cerevisiae COX6
ferric reductase transmembrane component, putative
7 probable transmembrane helices predicted by TMHMM2.0 at aa 15-37, 58-80, 95-112, 133-155, 165-187, 194-216 and 221-238; Similar to S. cerevisiae FRE8; In S. cerevisiae: protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; ferric-chelate reductase, putative
Similar to S. cerevisiae RAD30; In S. cerevisiae: RAD30 gene product (DNA polymerase eta) is involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins.; Protein similar to S. cerevisiae protein with role in nucleotide excision repair; down-regulation associated with azole resistance.
nonsense-mediated mrna decay protein, putative
Similar to S. cerevisiae NMD2; up-frameshift suppressor, putative
mitochondrial 54S ribosomal protein YmL35
AP-1-like transcription factor, putative
Similar to S. cerevisiae YAP6; basic leucine zipper (bZIP) transcription factor, putative
hypothetical wry family protein, conserved
flavin-dependent monooxygenase, putative
Similar to S. cerevisiae FMO1; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 269-291; thiol-specific monooxygenase, putative
4-aminobutyrate aminotransferase, putative
Similar to S. cerevisiae UGA1; In S. cerevisiae: Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; gaba aminotransferase, putative; gaba transaminase, putative; gamma-amino-n-butyrate transaminase, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.986, signal anchor probability 0.001) with cleavage site probability 0.808 between residues 17 and 18; secreted aspartyl protease, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.973, signal anchor probability 0.002) with cleavage site probability 0.392 between residues 19 and 20; secreted aspartyl protease, putative
positive regulator for mannosylphosphate transferase, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.621, signal anchor probability 0.378) with cleavage site probability 0.392 between residues 24 and 25; Similar to S. cerevisiae MNN4; In S. cerevisiae: a putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases.
Similar to S. cerevisiae NTA1; In S. cerevisiae: amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; protein N-terminal amidase, putative
positive regulator of mannosylphosphate transferase, putative
Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.128, signal anchor probability 0.864) with cleavage site probability 0.038 between residues 34 and 35; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 17-39; Similar to S. cerevisiae MNN4; fungal-specific; In S. cerevisiae: putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases.
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.818, signal anchor probability 0.008) with cleavage site probability 0.424 between residues 18 and 19; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 4-26; GPI-Anchor Signal predicted by DGPI v2.04 with cleavage site probability 0.408 near 71
serine/threonine-protein kinase, putative
Gag ORF flanked by inverted LTRs, each LTR followed by PBS, one LTR truncated
transposable element; Similar to Ty3/gypsy-like retrotransposons in Candida albicans and Candida dubliniensis
Similar to S. cerevisiae STE11; In S. cerevisiae: signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p.
calcineurin-like phosphoesterase, putative
Signal anchor predicted for SignalP 2.0 HMM (Signal peptide probability 0.207, signal anchor probability 0.793) with cleavage site probability 0.157 between residues 28 and 29; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 7-29; Similar to S. cerevisiae DCR2; In S. cerevisiae: putative phosphoesterase that functions as a dosage-dependent positive regulator of the G1/S phase transition by controlling the timing of START.; In C. albicans: putative DNA repair exonuclease; fungal-specific (no human or murine homolog); dosage-dependent cell cycle regulator, putative; phosphatase, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.948, signal anchor probability 0.010) with cleavage site probability 0.261 between residues 25 and 26
1 probable transmembrane helix predicted by TMHMM2.0 at aa 637-659; In S. cerevisiae: Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function.; Similar to S. cerevisiae COY1
spliced gene; Similar to S. cerevisiae RPL21A
spliced gene; Similar to S. cerevisiae RPS9B
basic helix-loop-helix transcription factor
spliced gene; Similar to S. cerevisiae INO4; In S. cerevisiae: transcription factor required for derepression of inositol-choline regulated genes involved in phospholipid synthesis; has not so far been described in C. albicans; protein INO4, putative
glucosamine 6-phosphate n-acetyltransferase, putative
Similar to S. cerevisiae GNA1; In S. cerevisiae: evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA.; In C. albicans: glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection; phosphoglucosamine acetylase, putative; phosphoglucosamine transacetylase, putative
small nuclear ribonucleoprotein G (snRNP-G), putative
spliced gene; Similar to S. cerevisiae SMX2
In C. albicans: protein likely to be essential for growth, based on an insertional mutagenesis strategy
Similar to S. cerevisiae IES1; INO80 chromatin remodelling complex subunit, putative
1 probable transmembrane helix predicted for ZZZ3520 by TMHMM2.0 at aa 5-27; Similar to S. cerevisiae MNL1; In S. cerevisiae: alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides.
GPI ethanolamine phosphate transferase, putative
15 probable transmembrane helices predicted by TMHMM2.0 at aa 39-61, 463-485, 497-519, 524-546, 566-588, 598-620, 625-644, 664-686, 693-715, 741-760, 805-827, 831-853, 904-926, 941-963 and 983-1005; Similar to S. cerevisiae GPI13; In S. cerevisiae: ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein.; In C. albicans: protein of major facilitator superfamily; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi13p, which acts in GPI anchor biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis protein, putative
Similar to S. cerevisiae SCH9; In S. cerevisiae: protein kinase that regulates signal transduction activity and G1 progression, controls cAPK activity, required for nitrogen activation of the FGM pathway, involved in life span regulation, homologous to mammalian Akt/PKB.; In C. albicans: protein required for chlamydospore formation and for embedded hyphal growth, not essential for viability; similar to S. cerevisiae Sch9p, which is a protein kinase involved in growth control.
mitochondrial 54S ribosomal protein YmL24/YmL14
eIF-2B GDP-GTP exchange factor subunit beta, putative
Similar to S. cerevisiae GCD7; In S. cerevisiae: beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; guanine nucleotide exchange factor subunit, putative; negative regulator of GCN4 expression, putative; translation initiation factor eIF-2B subunit beta, putative
In C. albicans: redicted ORF in Assemblies 19 and 20; protein detected in some, not all, biofilm extracts; fluconazole-downregulated; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type; transcription is upregulated in response to treatment with ciclopiroxolamine.
leucine-ruch repeat protein, hypothetical
Similar to S. cerevisiae SDS22; In S. cerevisiae: conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis; protein phosphatase 1 regulatory subunit, putative
NADH-ubiquinone oxidoreductase subunit, putative
Similar to S. cerevisiae ACP1; acyl carrier protein, mitochondrial precursor, putative
In S. cerevisiae: protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors).; In C. albicans: transposon mutation affects filamentous growth; dedicator of cytokinesis protein, putative; guanine nucleotide exchange factor, putative
10 probable transmembrane helices predicted for ZZZ3670 by TMHMM2.0 at aa 323-345, 380-402, 412-434, 447-469, 521-543, 562-584, 693-715, 728-750, 774-796 and 803-825; Similar to S. cerevisiae SSY1; In S. cerevisiae: component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes.; In C. albicans: amino acid sensor, required for wild-type hyphal growth on solid serum or Lees media, but not for hyphal growth under all conditions.
1 probable transmembrane helix predicted by TMHMM2.0 at aa 271-293; In S. cerevisiae: GFP-fusion protein localizes to mitochondrion
Similar to S. cerevisiae HFM1; In S. cerevisiae: meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity.
Similar to S. cerevisiae NOP12; In S. cerevisiae: nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe.
Similar to S. cerevisiae DEP1; In S. cerevisiae: transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation.
Similar to S. cerevisiae CHS5; In S. cerevisiae: protein involved in export from the Golgi to plasma membrane; involved in chitin biosynthesis through its role in Chs3p localization; interacts with Arf1p, Bch1p, Fmp50p, Bud7p, and Chs6p.; In C. albicans: putative chitin biosynthesis protein; fungal-specific (no human or murine homolog); transcription decreases upon yeast-to-hyphal switch.
Similar to S. cerevisiae VMA7; In S. cerevisiae: subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane.; In C. albicans: putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p; v-ATPase subunit, putative; vacuolar ATP synthase subunit F, putative; vacuolar proton pump F subunit, putative
In S. cerevisiae: GFP-fusion of homologous protein (SGD:YGR021W) localizes to the mitochondrion
2 probable transmembrane helices predicted for ZZZ3770 by TMHMM2.0 at aa 192-214 and 234-256
Similar to S. cerevisiae TBF1; In S. cerevisiae: telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation; TTAGGG repeat-binding factor, putative; protein TBF1, putative
guanine nucleotide-binding protein subunit beta, putative
Similar to S. cerevisiae STE4; In C. albicans: protein similar to S. cerevisiae Ste4p, the beta subunit of the G protein of mating signal transduction in S. cerevisiae; transcription is specific to cells homozygous at MTL and is induced by alpha pheromone.; In S. cerevisiae: G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats.
Similar to S. cerevisiae TAF14; In S. cerevisiae: subunit (30 kDa) of TFIID, TFIIF, and SWI/SNF complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domain; TBP-associated factor, putative; transcription factor, putative; transcription initiation factor TFIID subunit, putative; transcription initiation factor TFIIF subunit, putative
5' truncated in ORF1 and with middle of ORF2 replaced by 5' end and start of ORF1 in opposite orientation (and with eta LTR inserted in 3' UTR).
polyprotein of l1-like non-ltr retrotransposon zorro 3, putative
non-ltr retrotransposon zorro 3 orf1-related protein, putative
branched-chain-amino-acid aminotransferase, cytosolic, putative
Similar to S. cerevisiae BAT2; In S. cerevisiae: cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase.; In C. albicans: protein described as a branched chain amino acid aminotransferase; regulated by Gcn4p, Gcn2p; induced in response to amino acid starvation (3-aminotriazole treatment).
Similar to S. cerevisiae HYM1; In S. cerevisiae: component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response.
vacuolar protein sorting protein, putative
Similar to S. cerevisiae VPS36; In S. cerevisiae: component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome.; In C. albicans: protein involved in proteolytic activation of Rim101p, which regulates pH response; similar to S. cerevisiae Vps36p, which is a member of the ESCRT II protein sorting complex.
meiotic mRNA stability protein kinase, putative
Similar to S. cerevisiae SSN3; In S. cerevisiae: cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression.
Similar to S. cerevisiae CAK1; In C. albicans: monomeric CDK-activating kinase (CAK); functional homolog of S. cerevisiae Cak1p; phosphorylates cyclin-free human CDK2; lacks glycine loop motif; conserved lysine (K36) not required for activity.; In S. cerevisiae: cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; cyclin-dependent kinase-activating kinase, putative; serine/threonine-protein kinase, putative
spliced gene; 1 probable transmembrane helix predicted by TMHMM2.0 at aa 280-297
Similar to S. cerevisiae MDS1; In S. cerevisiae: protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; serine/threonine-protein kinase, putative
3 probable transmembrane helices predicted by TMHMM2.0 at aa 105-127, 169-191 and 198-220; In S. cerevisiae: protein of unknown function involved in maintenance of proper telomere length.
Similar to S. cerevisiae ERG10; In C. albicans: protein similar to acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in relative protein abundance are associated with resistance to azole antifungal drugs; fluconazole or ketoconazole induced.; In S. cerevisiae: acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis.; two isoforms of this enzyme have been characterized in Candida tropicalis, with the gene names PACTA and PACTB; acetyl-coa acetyltransferase, putative; ergosterol biosynthesis protein, putative
3 probable transmembrane helices predicted by TMHMM2.0 at aa 20-42, 194-216 and 244-266; In S. cerevisiae: protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts.
SGD entry needs updating; UniProt is current; gluconokinase, putative
ATP-dependent RNA helicase, mitochondrial precursor, putative
Similar to S. cerevisiae SUV3; In S. cerevisiae: ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Msu1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs.; In C. albicans: protein required for chlamydospore formation, for embedded hyphal growth, and for wild-type respiratory growth; similar to S. cerevisiae Suv3p, which is an RNA helicase involved in mitochondrial RNA catabolism.
folylpoly-gamma-glutamate synthetase, putative
Similar to S. cerevisiae MET7; In S. cerevisiae: folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; folylpolyglutamate synthase, putative; tetrahydrofolate synthase, putative; tetrahydrofolylpolyglutamate synthase, putative
covalently-linked cell wall protein precursor, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.997, signal anchor probability 0.000) with cleavage site probability 0.584 between residues 18 and 19; Similar to S. cerevisiae CIS3; In S. cerevisiae: mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family; soluble cell wall protein, putative
hypothetical leucine-rich repeat family protein, conserved
homocitrate synthase, mitochondrial precursor, putative
Similar to S. cerevisiae LYS21; In S. cerevisiae: homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p.
Similar to S. cerevisiae ADH1; In S. cerevisiae: alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway.
TATA-binding protein-associated factor, putative
2 probable transmembrane helices predicted by TMHMM2.0 at aa 1166-1188 and 1208-1230; Similar to S. cerevisiae MOT1; In S. cerevisiae: essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; TBP-associated factor, putative; helicase, putative; modifier of transcription, putative
Similar to S. cerevisiae RIM2; In S. cerevisiae: mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family.
RNA polymerase II mediator complex subunit, putative
Similar to S. cerevisiae MED8; In S. cerevisiae: subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; RNA polymerase II transcriptional regulation mediator, putative
Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.996, signal anchor probability 0.003) with cleavage site probability 0.873 between residues 19 and 20; 5 probable transmembrane helices predicted by TMHMM2.0 at aa 137-159, 169-186, 257-276, 296-318 and 325-347; In S. cerevisiae: GFP-fusion protein localizes to vacuole; function unknown, but known to be essential
NADH dehydrogenase complex I subunit, putative
In C. albicans: subunit of nicotinamide adenine dinucleotide dehydrogenase complex I, of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline downregulated.
1 probable transmembrane helix predicted by TMHMM2.0 at aa 5-27; Similar to S. cerevisiae KTR2; In S. cerevisiae: mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family.
Similar to S. cerevisiae EBP2; In S. cerevisiae: essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA-processing protein, putative
Similar to S. cerevisiae FPP1; In S. cerevisiae: farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis.; In C. albicans: putative farnesyl pyrophosphate synthetase involved in isoprenoid and sterol biosynthesis, based on similarity to S. cerevisiae Erg20p; likely to be essential for growth, based on an insertional mutagenesis strategy; farnesyl diphosphate synthetase, putative; farnesyl pyrophosphate synthetase, putative; geranyltranstransferase, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 57-74; Similar to S. cerevisiae QCR8; In S. cerevisiae: subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p; cytochrome b-c1 complex subunit 8, putative; ubiquinol-cytochrome c reductase complex protein, putative; ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C, putative
Similar to S. cerevisiae RPL17B; In S. cerevisiae: protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins.; In C. albicans: predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage.
SWI/SNF complex component SWI3, putative
Similar to S. cerevisiae SWI3; In S. cerevisiae: subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; chromatin remodelling complex subunit, putative; transcription regulatory protein SWI3, putative
U5 small nuclear ribonucleoprotein component, putative
Similar to S. cerevisiae SNU114; In S. cerevisiae: GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2.; Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
DNA-directed RNA polymerase II subunit, putative
Similar to S. cerevisiae RPB4; In S. cerevisiae: RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance.
dual specificity protein kinase, putative
Similar to S. cerevisiae YAK1; In C. albicans: induced in core caspofungin response; In S. cerevisiae: serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal.
mitochondrial import inner membrane translocase subunit, putative
2 probable transmembrane helices predicted by TMHMM2.0 at aa 13-35 and 89-108; Similar to S. cerevisiae TIM17; In S. cerevisiae: essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import; mitochondrial inner membrane protein, putative; mitochondrial protein import protein, putative
12 probable transmembrane helices predicted by TMHMM2.0 at aa 88-110, 120-142, 173-195, 210-229, 241-263, 286-308, 321-343, 371-393, 430-449, 454-476, 489-511 and 521-543; In S. cerevisiae: protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles.
In S. cerevisiae: possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data.
Similar to S. cerevisiae URE2; In S. cerevisiae: nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion.; In C. albicans: plays an important role in the cellular response to the nitrogen source. ure2 gene plays a major part in the repression of gln1 and gdh2 genes by glutamine, and is required for the inactivation of glutamine synthetase. ure2 gene product may catalytically inactivate gln3 in response to an increase in the intracellular concentration of glutamine.
in-frame stop codons; Similar to C. albicans LPF29; Similar to C. albicans FGR51; possibly Candida-specific; Similar to a C.albicans gene family identified as FGR (filamentous growth regulator) genes; designated FGR1, FGR2, etc.
nuclear pore complex component, putative
2 probable transmembrane helices predicted by TMHMM2.0 at aa 250-272 and 311-333
possibly involved in initiation of septation: see Pfam hit
9 probable transmembrane helices predicted by TMHMM2.0 at aa 5-27, 87-106, 111-133, 140-162, 193-215, 264-286, 306-328, 333-355 and 365-387; Signal peptide predicted by SignalP 2.0 HMM (Signal peptide probability 0.801, signal anchor probability 0.105) with cleavage site probability 0.327 between residues 26 and 27
Similar to S. cerevisiae KIC1; In S. cerevisiae: protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; kinase that interacts with cdc31, putative; serine/threonine-protein kinase, putative
Similar to S. cerevisiae SWC3; In S. cerevisiae: protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae.
mitochondrial 37S ribosomal protein MRP51
Similar to S. cerevisiae MRP51; In S. cerevisiae: mitochondrial ribosomal protein of the large subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences.
mitochondrial inheritance component Mdm10p, putative
Similar to S. cerevisiae MDM10; In S. cerevisiae: subunit of the mitochondrial sorting and assembly machinery (SAM complex); has a role in assembly of the TOM complex, which mediates protein import through the outer membrane; required for normal mitochondrial morphology and inheritance; mitochondrial outer membrane protein, putative
imidazoleglycerol-phosphate dehydratase, putative
Similar to S. cerevisiae HIS3; In S. cerevisiae: imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p.
Similar to S. cerevisiae PET56; In S. cerevisiae: ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA.
1 probable transmembrane helix predicted by TMHMM2.0 at aa 267-289
hypothetical protein, C. dubliniensis-specific
LAS seventeen-binding protein 3, putative
spliced gene; possible intron; In S. cerevisiae: protein involved in the organization of the actin cytoskeleton.
Similar to S. cerevisiae TFC2; In S. cerevisiae: transcription factor IIIA (TFIIIA), essential protein with nine C2H2 Zn-fingers, binds the 5S rRNA gene through the zinc finger domain and directs assembly of a multiprotein initiation complex for RNA polymerase III; also binds DNA; zinc finger-containing transcription factor, putative
Similar to S. cerevisiae RLR1; In S. cerevisiae: subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; protein THO2 homologue, putative
NADPH:adrenodoxin oxidoreductase homolog, mitochondrial precursor, putative
Similar to S. cerevisiae ARH1; In S. cerevisiae: oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; adrenodoxin reductase homolog, putative
unknown EC_number=2/7/11/23; In C. albicans: protein kinase of the Cdc2 kinase subfamily; required for hyphal development and virulence; serine/threonine-protein kinase, putative
12 probable transmembrane helices predicted by TMHMM2.0 at aa 65-87, 110-132, 139-161, 167-189, 196-214, 224-246, 313-332, 352-374, 381-403, 418-440, 461-483 and 488-510; Similar to S. cerevisiae ITR2; In S. cerevisiae: myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively.; In C. albicans: putative glucose transporter of major facilitator superfamily; C. albicans glucose transporter family comprises 20 members; 12 probable transmembrane motifs; expressed in rich medium with 2% glucose; fluconazole, caspofungin downregulated.
1 probable transmembrane helix predicted for ZZZ4440 by TMHMM2.0 at aa 12-34; Similar to S. cerevisiae CTC1; In S. cerevisiae: cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex; cytochrome b-c1 complex subunit cyt1, putative; cytochrome c1, heme protein, mitochondrial precursor, putative; ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit, putative
Similar to S. pombe AIN1; putative role in actin-ring formation and organization; putative role in cytokinesis and septation; alpha-actinin-like protein, putative
casein kinase II subunit alpha', putative
Similar to S. cerevisiae CKA2; In C. albicans: catalytic subunit (alpha-subunit) of protein kinase CK2; interaction with calcineurin pathway to affect fluconazole sensitivity; not essential for viability; synthetically lethal with CKA1; similar to S. cerevisiae Cka2p.; In S. cerevisiae: alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases.
mitochondrial morphogenesis protein, putative
In S. cerevisiae: required for mitochondrial morphology
mitochondrial 54S ribosomal protein YmL10/YmL18
Similar to S. cerevisiae MRPL10; In S. cerevisiae: mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels.
early meiotic induction protein, putative
Similar to S. cerevisiae EMI1; In S. cerevisiae: non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation.
spliced gene; Similar to S. cerevisiae RHO3; In S. cerevisiae: non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p.; In C. albicans: putative Rho family GTPase; possible substrate of protein farnesyltransferase and geranylgeranyltransferase type I; greater transcription in hyphal form than yeast form.; possible intron; protein rho3, putative
1 probable transmembrane helix predicted by TMHMM2.0 at aa 68-90
Similar to S. cerevisiae GNT1; Signal anchor predicted by SignalP 2.0 HMM (Signal peptide probability 0.040, signal anchor probability 0.721) with cleavage site probability 0.032 between residues 47 and 48; n-acetylglucosaminyltransferase, putative
Similar to S. cerevisiae SRX1; In S. cerevisiae: sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes; sulphiredoxin, putative
ferric reductase transmembrane component precursor, putative
Similar to S. cerevisiae FRE2; ferric-chelate reductase, putative
GFP-fusion protein localizes to nucleolus; non-essential gene
Similar to S. cerevisiae MAK5; maintenance of killer protein, putative
eukaryotic peptide chain release factor subunit, putative
Similar to S. cerevisiae SUP1; In S. cerevisiae: polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor.; In C. albicans: putative translation release factor 1, which interacts with stop codons and promotes release of nascent peptides from ribosomes; eukaryotic release factor, putative; omnipotent suppressor protein, putative
alkylphosphocholine resistance protein, putative
Similar to S. cerevisiae LEM3; brefeldin-a sensitivity protein, putative
Similar to Pongo pygmaeus ZADH1; zinc-binding alcohol dehydrogenase, putative
Similar to S. cerevisiae PEX2; peroxisomal biogenesis factor, putative; peroxisomal protein, putative
pumilio-family RNA binding domain-containing protein
In C. albicans: cytoplasmic protein expressed specifically in white phase yeast-form cells; expression in opaque cells increases virulence and frequency of opaque-to-white switching; null mutant shows wild-type switching; similar to S. cerevisiae Hsp12p.
DASH complex subunit DAD2 homologue, putative
Similar to S. cerevisiae DAD2; DUO1 and DAM1-interacting protein, putative; helper of ASK1 protein, putative; outer kinetochore protein DAD2, putative
Similar to S. cerevisiae NUP133; nucleoporin, putative
aspartate aminotransferase, cytoplasmic, putative
Similar to S. cerevisiae AAT2; transaminase A, putative
Similar to S. cerevisiae KAP104; In S. cerevisiae: involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm; karyopherin beta-2 subunit, putative; transportin, putative
phosphatidylinositol N-acetylglucosaminyltransferase subunit, putative
protein ERP3 precursor homologue, putative
mitochondrial 37S ribosomal protein MRPS35
DNA-directed RNA polymerases I and III subunit, putative
Similar to S. cerevisiae RPC5; In S. cerevisiae: RNA polymerase subunit, common to RNA polymerase I and III
Similar to S. cerevisiae BIO6; biotin biosynthesis enzyme, putative
spliced gene; Similar to S. cerevisiae RPL31B; In S. cerevisiae: RPL31A and RPL31B gene products are almost identical
Similar to S. cerevisiae PEX6; peroxisomal biogenesis factor, putative; peroxisome biosynthesis protein, putative
Similar to S. cerevisiae MDJ2; mitochondrial membrane chaperonin, putative
ubiquinone biosynthesis methyltransferase, mitochondrial precursor, putative
ATP synthase subunit, mitochondrial precursor, putative
chromatin assembly factor 1 (CAF1) subunit, putative
Similar to S. cerevisiae YRB2; Ran-specific GTPase-activating protein, putative
U1 small nuclear ribonucleoprotein, putative
spliced gene; Similar to S. cerevisiae SNP1
Similar to S. cerevisiae DAP1; sterol binding protein, putative
NADPH-dependent methylglyoxal reductase, putative
Similar to S. cerevisiae AST2; protein ast2 homologue, putative
diphthamide biosynthesis protein, putative
vacuolar protein sorting-associated protein vps35 homologue, putative
peptide-n4-(n-acetyl-beta-d-glucosaminyl) asparaginase amidase n, putative
Similar to S. cerevisiae SEN34; tRNA-intron endonuclease, putative; tRNA-splicing endonuclease subunit, putative
golgi transport complex subunit, putative
NADH-dependent fumarate reductase, putative
spliced gene; Similar to S. cerevisiae RPL33A
Similar to S. cerevisiae KES1; protein kes1 homologue, putative
GPI-anchored wall transfer protein, putative
integral nuclear/ER membrane protein, putative
Similar to S. cerevisiae SPO7; sporulation-specific protein, putative
from Pfam: this nucleolar family of proteins are involved in 60S ribosomal biogenesis; specifically, in the processing beyond the 27S stage of 25S rRNA maturation.
hypothetical zinc finger protein, Candida conserved
mitogen-activated kinase kinase (MAKK), putative
Similar to S. cerevisiae MKK1; In S. cerevisiae: involved in protein kinase C signaling pathway that controls cell integrity
spliced gene; Similar to S. cerevisiae RFC1
Golgi matrix protein involved in the structural organization of the cis-Golgi, putative
conserved oligomeric golgi complex subunit, putative
Similar to S. cerevisiae XBP1; transcriptional repressor, putative
isocitrate dehydrogenase [nadp], mitochondrial precursor, putative
Similar to S. cerevisiae IDP1; oxalosuccinate decarboxylase, putative
cleavage and polyadenylation factor (CF-IA) component, putative
Similar to S. cerevisiae PCF11; In S. cerevisiae, CF-IA is involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II; mRNA 3' end processing factor, putative; mRNA cleavage and polyadenylylation specificity factor, putative
cytochrome c oxidase polypeptide viii, mitochondrial precursor, putative
cytochrome c oxidase subunit 7a precursor (ec 1.9.3.1) (cytochrome oxidase polypeptide viia)
homotypic vacuole fusion and vacuole protein sorting (HOPS) complex subunit, putative
Similar to S. cerevisiae TES5; In S. cerevisiae, likely to be involved in fatty acid oxidation rather than fatty acid synthesis; TES1 mRNA levels increase during growth on fatty acids
peroxisomal Acyl-CoA thioesterase Tes1p, putative
bud formation and morphogenesis protein, putative
In S. cerevisiae, essential nuclear protein; mutants require the SSD1-v allele for viability
peripheral membrane protein, vesicular trafficking, putative
Similar to S. cerevisiae ATG2; In S. cerevisiae, required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; interacts with Atg9p and is necessary for its trafficking
concentrative nucleoside transporter 2, putative
Similar to Rattus norvegicus CNT2; na(+)/nucleoside cotransporter [2], putative; sodium-coupled nucleoside transporter [2], putative; sodium/nucleoside cotransporter [2], putative; sodium/purine nucleoside cotransporter, putative
Similar to S. cerevisiae SLI1; In S. cerevisiae, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
long chain fatty acyl-coa synthetase [2], putative; long-chain-fatty-acid--CoA ligase [2], putative
Similar to S. pombe TNR3; thiamine pyrophosphokinase, putative
dolichyl-phosphate-mannose--protein mannosyltransferase, putative
Similar to S. cerevisiae PPX1; exopolyphosphatase, putative; metaphosphatase, putative
chromosome segregation/replication protein, putative
26s proteasome 19S regulatory particle non-ATPase subunit, putative
Similar to S. cerevisiae RPN10; In S. cerevisiae, N-terminus plays a role in maintaining the structural integrity of the regulatory particle; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein; multiubiquitin binding protein, putative
sulfite reductase [nadph] beta subunit, putative
Similar to S. cerevisiae ECM17; In S. cerevisiae, involved in amino acid biosynthesis, transcription repressed by methionine
threonine dehydratase, mitochondrial precursor, putative
Similar to S. cerevisiae ILV1; threonine dehydratase, putative
Similar to S. cerevisiae SER1; In S. cerevisiae, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p
cleavage and polyadenylation factor specificity complex subunit, putative
Similar to S. cerevisiae YSH1; In S. cerevisiae, putative endonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs; endonuclease, putative
small nuclear ribonucleoprotein sm d2, putative
spliced gene; Similar to S. cerevisiae SMD2; In S. cerevisiae, core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2; small nuclear riboucleoprotein (snrnp) core protein d2, putative
DNA licensing factor helicase subunit, putative
Similar to S. cerevisiae MCM5; In S. cerevisiae, component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; MCM complex helicase subunit, putative; chromosome replication minichromosome maintenance, putative
Similar to S. cerevisiae YHC1; U1 snRNP complex, putative; pre-mRNA splicing complex subunit, putative
GTP-binding nuclear protein, Ran family member, putative
Similar to S. cerevisiae GSP1; In S. cerevisiae, involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
Similar to S. cerevisiae NAB6; Similar to S. pombe NRD1
aminoacid vacuolar transporter, putative
In S. cerevisiae, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; vacuolar transporter, vesicular GABA-glycine transporters family member, putative
nuclear regulator/transcription factor, cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway, pseudohyphal differentiation, putative
Similar to S. cerevisiae SOK2; In S. cerevisiae, negatively regulates pseudohyphal differentiation; homologous to several transcription factors
4-hydroxyphenylpyruvate dioxygenase, putative
Similar to S. cerevisiae MAK16; In S. cerevisiae, essential nuclear protein; required for normal concentration of free 60S ribosomal subunits; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
Similar to S. cerevisiae SCP1; calponin-like actin-binding protein, putative; transgelin, putative
spliced gene; In C. albicans: functional basis of mycophenolic acid resistance
serine/threonine-protein phosphatase B-type regulatory subunit, putative
ethanol metabolism and heat shock tolerance protein, putative
oxidoreductase, degenerate fragmented pseudogene, putative; Similar to S. cerevisiae GRE2; In S. cerevisiae, NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
Similar to S. cerevisiae RSB1; In S. cerevisiae, suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; integral membrane transporter, putative
Similar to S. cerevisiae RSB1; integral membrane transporter, putative
trna (guanine-n(1)-)-methyltransferase, putative
Similar to S. cerevisiae TRM10; trna methyltransferase [10], putative
Similar to S. cerevisiae PNG1; In S. cerevisiae, conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation, localizes to the cytoplasm and nucleus, interacts with the DNA repair protein Rad23p
mitochondrial thiamine pyrophosphate transporter, mitochondrial carrier family member, putative
Similar to S. cerevisiae TPC1; In S. cerevisiae, mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
Similar to S. pombe CTA4; Similar to S. cerevisiae SPF1; In S. cerevisiae, involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; P-type ATPase, putative; cation transporting ATPase, putative
mannose-containing glycoprotein, cell wall constituent, PIR family member, putative
plasma membrane permease, glycerophosphoinositol and glycerophosphocholine uptake, putative
Similar to S. cerevisiae GIT1; In S. cerevisiae, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
Similar to S. pombe DSK1; Similar to S. cerevisiae SKY1; In S. cereviaie, involved in regulating proteins involved in mRNA metabolism and cation homeostasis
conserved oligomeric Golgi complex component, putative
Similar to S. cerevisiae COG8; In S. cerevisiae, the Cog1p through Cog8p complex is a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
valine--trna ligase, mitochondrial precursor, putative
Similar to S. cerevisiae VAS1; valyl-trna synthetase, mitochondrial precursor, putative
pre-mrna-splicing factor, U4/U6-U5 snRNP complex component, putative
exosome 3->5 exonuclease complex component, rRNA processing, putative
Similar to S. cerevisiae RRP46; ribosomal rna-processing protein [46], putative
serine/threonine-protein kinase, transcription and stress response, putative
Similar to S. cerevisiae ATO2; In S. cerevisiae, required for normal sporulation
In S. cerevisiae, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
Similar to S. cerevisiae GRE2; In S. cerevisiae, stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; NADPH-dependent methylglyoxal reductase, putative
integral membrane protein, eisosome component, putative
Similar to S. cerevisiae PIL1; In S. cerevisiae, eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; negative effector of stress resistance pathways, putative
Similar to S. cerevisiae RDS3; In S. cerevisiae, involved in pre-mRNA splicing and cycloheximide resistance
Similar to S. cerevisiae PRE2; multicatalytic endopeptidase complex subunit, putative; proteasome component, putative; proteinase ysce subunit, putative
fork head like transcriptional regulator, putative
Similar to S. pombe FHL1; yeast conserved, C-terminal domain extension of unknown function; required for rRNA processing, putative
Similar to S. cerevisiae SPR1; sporulation-specific glucan 1,3-beta-glucosidase precursor, putative
unable to locate translational start codon
Similar to S. cerevisiae PST2; In S. cerevisiae, induced by oxidative stress in a Yap1p dependent manner
In S. cerevisiae, involved in protein degradation in the vacuole and required for full protein degradation during sporulation; vacuolar serine protease, yscb/subtilisin family, putative
In S. cerevisiae, involved in arabinose and xylose metabolism
Similar to S. cerevisiae ARE2; sterol-ester synthase 2, putative
Similar to S. cerevisiae AAH1; shows colony morphology-related gene regulation by Ssn6p; Hog1p-, biofilm-induced; adenosine deaminase involved in purine salvage and nitrogen catabolism, putative
box C/D snoRNA processing protein, putative
Similar to S. cerevisiae BCD1; In S. cerevisisae YHR040W is an essential protein required for the accumulation of box C/D snoRNA
spliceosome associated protein, putative
replication factor A protein 2, putative
serine/threonine protein kinase, putative
putative mitochondrial 54S ribosomal protein MNP1
DNA-directed RNA polymerase II subunit 9, putative
Catalytic subunit of cAMP-dependent protein kinase (PKA), putative
transcription factor with zinc cluster DNA-binding motif, putative
succinyl-coa:alpha-ketoacid-coa transferase, putative
6-chlorohydroxyquinol-1,2-dioxygenase, putative
Subunit of the cytosolic chaperonin Cct ring complex, putative
Protein involved in DNA replication, putative
RNA terminal phosphate cyclase-like protein, putative
Similar to S. cerevisiae TAF4; involved in RNA polymerase II transcription initiation, putative
Non-SMC subunit of the condensin complex, putative
Similar to S. cerevisiae YCS4; required for establishment and maintenance of chromosome condensation
membrane bound o-acyl transferase, putative
transcription is not regulated by iron levels and is not affected by a yfh1 null mutation; Similar to S. cerevisiae HEM15
subunit of the RNA polymerase II mediator complex, putative
Similar to S. cerevisiae NAM8; In S. cerevisiae: this is an RNA binding protein, component of the U1 snRNP protein. Mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA.
meiosis-specific serine/threonine-protein kinase MEK1, putative
spliced gene; merged with adjacent CDS (Cd36_21810); Similar to S. cerevisiae MEK1
ribonucleoside diphosphate reductase, putative
Similar to S. cerevisiae VMA10; v-atpase subunit, putative; vacuolar ATP synthase subunit G, putative; vacuolar proton pump G subunit, putative
protein involved in RNA metabolism, putative
precocious dissociation of sisters protein, putative
Similar to S. cerevisiae PDS5; sister chromatid cohesion protein, putative
Similar to S. cerevisiae GLE1; nuclear pore protein, putative; nucleoporin, putative
mitochondrial 54S ribosomal protein YmL7/YmL5
Similar to S. cerevisiae YVC1; yeast vacuolar conductance protein, putative
Similar to S. cerevisiae NST1; apparent -1 frameshift
cytochrome b pre-mRNA-processing protein, putative
lectin family integral membrane protein, putative
inorganic phosphate transporter, putative
Similar to S. cerevisiae FLC2; TRP-like ion channel, putative; flavin carrier protein, putative
Similar to S. cerevisiae FMO1; thiol-specific monooxygenase, putative
Similar to S. cerevisiae APM4; adaptin medium chain, putative; clathrin assembly protein complex medium chain, putative; clathrin coat assembly protein, putative; plasma membrane adaptor protein, putative
phosphoribosyl pyrophosphate synthetase, putative
Similar to S. cerevisiae PRPS5; ribose-phosphate pyrophosphokinase, putative
NAD-specific glutamate dehydrogenase, putative
Similar to S. cerevisiae VRP1; verprolin
Similar to S. cerevisiae ALG7; N-acetylglucosamine-1-phosphate transferase, putative; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative; tunicamycin resistance protein, putative
Similar to S. cerevisiae SEH1; nucleoporin, putative; sec13 homolog, putative
constituent of pre-ribosomal particles, putative
Similar to S. cerevisiae NSA1; ribosome biogenesis protein, putative; uncharacterized protein ygl111w
fumarylacetoacetate hydrolase family protein, putative
ATP-binding cassette protein involved in Ribosome Biogenesis, putative
Similar to S. cerevisiae ARB1; probable ATP-dependent transporter, putative
Similar to S. cerevisiae BLM10; proteasome activator, putative
spliced gene; Similar to S. cerevisiae RPS10A
Similar to S. cerevisiae ARN1; siderophore iron transporter, putative
mitochondrial RNA-splicing protein, putative
Similar to S. cerevisiae MRS4; mitochondrial carrier protein, putative; mitochondrial iron transporter, putative
mitochondrial cell death effector, putative
Similar to S. cerevisiae AIF1; pyridine nucleotide-disulphide oxidoreductase, putative; reductase, putative
repressor of RNA polymerase III transcription, putative
D-arabinose dehydrogenase [NAD(P)+] heavy chain, putative
Similar to S. cerevisiae ARA1; large subunit of NADP+ dependent arabinose dehydrogenase, putative
membrane traffic regulatory protein, putative
spliced gene; Similar to S. cerevisiae YOP1; protein yop1 homologue, putative
spliced gene; Similar to S. cerevisiae RRP14; ribosomal biogenesis protein, putative
Similar to S. cerevisiae VMA5; V-ATPase subunit, putative; vacuolar ATP synthase subunit C, putative; vacuolar proton pump C subunit, putative
acetyltransferase complex component, putative
Similar to S. cerevisiae EAF3; chromatin modification-related protein, putative
retrotransposon polyprotein, fragment, putative
phosphatidylinositol 4,5-bisphosphate 5-phosphatase, putative
Similar to S. cerevisiae INP52; synaptojanin-like protein, putative
Similar to S. cerevisiae TEF2; elongation factor 1-alpha, putative; eukaryotic elongation factor 1a, putative; translation elongation factor 1a, putative
DNA replication regulator dpb11, putative
Similar to S. cerevisiae DPB11; S-M checkpoint control protein, putative
3-methyladenine DNA glycosidase, putative
Similar to S. cerevisiae MAG1; 3MEA DNA glycosylase, putative; DNA-3-methyladenine glycosylase, putative
Similar to S. cerevisiae RRP8; ribosomal RNA-processing protein, putative
Similar to S. cerevisiae YNG2; histone acetyltransferase complex subunit, putative
putative retrotransposon tca3 polyprotein
exoribonuclease II, mitochondrial precursor, putative
Similar to S. cerevisiae DSS1; mitochondrial biogenesis protein, putative; ribonuclease II, putative
component of condensin complex, putative
Similar to S. cerevisiae SMC2; structural maintenance of chromosome 2 homologue, putative
aminonitrophenyl propanediol resistance protein, putative
Similar to S. cerevisiae ANP1; mannan polymerase II complex subunit, putative
Similar to S. cerevisiae FLO9; flocculin, putative
farnesyl-diphosphate farnesyltransferase, putative
fpp:fpp farnesyltransferase, putative; squalene synthetase, putative
RNA polymerase-associated protein, putative
spliced gene; Similar to S. cerevisiae PST2; protoplast secreted protein, precursor, putative
NADH-ubiquinone oxidoreductase subunit, mitochondrial precursor, putative
U3 small nucleolar RNA-associated protein, putative
Similar to S. cerevisiae UTP15; U3 snoRNA-associated protein, putative
Similar to S. cerevisiae MSH3; mismatch-binding protein, putative
Similar to S. cerevisiae IES2; subunit of INO80 chromatin remodeling complex, putative
Similar to S. cerevisiae TIF4631; eIF4F p150 homologue, putative; eIF4G1, putative; eukaryotic initiation factor 4F subunit p150 homologue, putative; mRNA cap-binding protein complex subunit p150 homologue, putative
26S protease regulatory subunit, putative
Similar to S. cerevisiae JEM1; dnaJ-like protein of the ER membrane, putative
Similar to S. cerevisiae IPP1; pyrophosphate phospho-hydrolase, putative
Similar to S. cerevisiae SPO11; sporulation-specific protein, putative
ER protein involved in chitin deposition in the cell wall, putative
subunit of an adoMet-dependent tRNA methyltransferase complex, putative
probable serine/threonine-protein kinase, putative
covalently-linked cell wall protein, putative
Similar to S. cerevisiae PIR1; protein pir1 homologue, putative; structural protein of cell wall, putative
possible positional orthologue of C. albicans BUD20; some very faint sequence similarity; position within genome suggests positional orthology with orf19.218 (BUD20)
ankyrin repeat-containing protein, putative
Similar to S. cerevisiae AVO2; potential TOR2 kinase complex component, putative
26s proteasome regulatory subunit, putative
Similar to S. cerevisiae RPN12; nuclear integrity protein, putative
vacuolar protein sorting-associated protein vps28 homologue, putative
3-oxo-5-alpha-steroid 4-dehydrogenase, putative
spliced gene; frameshift appears to be genuine - sequence reads consistent over this area
SIN3-binding protein 3 homologue, putative
Similar to S. cerevisiae STB3; protein STB3 homologue, putative
DNA replication licensing factor CDC47 homologue, putative
Similar to S. cerevisiae CDC47; may be incomplete at 3' end; cell division control protein, putative
asparagine synthetase [glutamine-hydrolyzing], putative
Similar to S. cerevisiae ASN2; glutamine-dependent asparagine synthetase, putative
GPI-anchored protein of unknown function, putative
subunit alpha of assimilatory sulfite reductase, putative
Similar to S. cerevisiae MET10; sulfite reductase [NADPH] flavoprotein component, putative
mannosyl phosphorylinositol ceramide synthase, putative
Similar to S. cerevisiae RRP45; ribosomal RNA-processing protein, putative
beta-subunit of the Snf1 kinase complex, putative
Similar to S. cerevisiae GAL83; glucose repression protein, putative
Similar to S. cerevisiae GLO2; hydroxyacylglutathione hydrolase, cytoplasmic isozyme, putative
subunit of SCF ubiquitin ligase complex, putative
Similar to S. cerevisiae SGT1; suppressor of G2 allele of SKP1 homologue, putative
vacuolar ATPase assembly integral membrane protein, putative
spliced gene; Similar to S. cerevisiae VMA21
nucleolar protein involved in rRNA processing, putative
Similar to S. cerevisiae NOP7; pescadillo homolog, putative; ribosome biogenesis protein, putative
Similar to S. cerevisiae TAZ1; lyso-phosphatidylcholine acyltransferase
Similar to S. cerevisiae RRP15; pre=rRNA processing protein, putative; ribosomal biogenesis protein, putative
Similar to S. cerevisiae ERG24; delta(14)-sterol reductase, putative; sterol C14-reductase, putative
Similar to S. cerevisiae PMS1; postmeiotic segregation protein, putative
processivity subunit of DNA polymerase zeta, putative
Similar to S. cerevisiae REV7; protein rev7 homologue, putative
calcium-binding mitochondrial carrier, putative
Similar to S. cerevisiae SAL1; suppressor of AAC2 lethality, putative
Similar to S. cerevisiae CCT2; T-complex protein 1 subunit beta, putative; TCP-1-beta, putative; TCP-1/cpn60 chaperonin family protein, putative; cytosolic chaperonin CCT ring complex, subunit beta, putative
Similar to S. cerevisiae FLO11 (MUC1, STA4); In S. cerevisiae: GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); cell wall adhesin, putative; cell wall protein, putative
cop9 signalosome complex subunit, putative
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, putative
Similar to S. cerevisiae AGE2; GTPase activating protein for Arf, putative; protein AGE2 homologue
mitochondrial phosphate carrier protein, putative
Similar to S. cerevisiae PIC2; phosphate transport protein, putative
mitochondrial NAD+ transporter, putative
Similar to S. cerevisiae YIA6; In S. cerevisiae: disputed role as a pyruvate transporter
protein disulfide-isomerase precursor, putative
phosphohexomutase, putative; phosphomannose isomerase, putative
cytoplasmic RNA-binding protein, putative
Similar to S. cerevisiae NOP16; ribosomal subunit biogenesis protein, putative
Similar to S. cerevisiae BET1; v-SNARE, putative; vesicular transport protein, putative
UDP-N-acetylglucosamine transporter, putative
LAS seventeen-binding protein 5 homologue, putative
eukaryotic peptide chain release factor GTP-binding subunit, putative
polypeptide release factor 3, putative; translation release factor 3, putative
arginine metabolism regulation protein III, putative
Similar to S. cerevisiae ARG82; inositol polyphosphate multikinase, putative
Similar to S. cerevisiae SSO2; syntaxin, putative; t-SNARE, putative
Similar to S. cerevisiae LEU4; alpha-ipm synthetase, putative; alpha-isopropylmalate synthase, putative
Similar to S. cerevisiae INP53; synaptojanin-like protein, putative
Similar to S. cerevisiae MTW1; kinetochore-associated protein, putative
iron/ascorbate family oxidoreductase, putative
conserved hypothetical transmembrane protein
fungus-specific chromosomal protein, putative
membrane import machinery protein, putative
Similar to S. cerevisiae TIM23; mitochondrial import inner membrane translocase subunit, putative; mitochondrial inner membrane protein, putative; mitochondrial protein import protein, putative
amino acid biosynthesis regulatory protein, putative
Similar to S. cerevisiae GCN4; general control protein GCN4 homologue, putative; transcriptional activator of amino acid biosynthetic genes, putative
Similar to S. cerevisiae SOL1; described as 6-phosphogluconase in P50278, but SGD notes that Sol1 does not exhibit this enzymatic activity, despite the sequence similarity; tRNA processing/export protein, putative
oligomycin resistance ATP-dependent permease, putative
Similar to S. cerevisiae YOR1; plasma membrane transporter of the ATP-binding cassette (ABC) family, putative
spliced gene; possibly C. dubliniensis-specific; no convincing Fasta/BlastP hits to known proteins
family 17 glucosidase, putative; glycosyl hydrolase, putative
Similar to S. cerevisiae UBP15; ubiquitin carboxyl-terminal hydrolase, putative; ubiquitin thioesterase, putative; ubiquitin-specific-processing protease, putative
pantetheine-phosphate adenylyltransferase (PPAT), putative
DNA-binding protein RAP1 homologue, putative
In S. cerevisiae: binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure; repressor/activator site-binding protein, putative
complexed with CEF1 protein 22, putative
Similar to S. cerevisiae CWC22; pre-mRNA-splicing factor, putative
Similar to S. cerevisiae PLP2; phosducin-like protein, putative; viral IAP-associated factor 1 homolog, putative
Similar to S. cerevisiae UPB8; In S. cerevisiae: component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B; ubiquitin carboxyl-terminal hydrolase, putative; ubiquitin thioesterase, putative; ubiquitin-specific protease, putative; ubiquitin-specific-processing protease, putative
glycosyl hydrolase, putative; mannan endo-1,6-alpha-mannosidase, putative; possible alpha-1,6-mannanase
core RPS block of MRS_1 consists of one complete RPS unit of 2106bp, plus one partial RPS unit of 1535bp; orientation = sense
Similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS_1
RPS (RePeat Sequence domain; last RPS unit is partial
similar to Q59KJ3: ORF in C. albicans Major Repeat Sequence, RB2 region
Defective cell wall 1 homologue, putative
Similar to Candida glabrata DCW1; Endo-alpha-1->6-D-mannanase DCW1 homologue, putative; alpha-1,6-mannanase, putative; glycosyl hydrolase family 76, putative; mannan endo-1,6-alpha-mannosidase, putative
Similar to S. cerevisiae OST2; Oligosaccharyl transferase subunit, putative
CGD describes this gene as orthologous to S. cerevisiae RAS2, not RAS1; RAS signal transduction GTPase, putative; Ras homolog type B, putative; Ras-like protein 1, putative
subunit of histone deacetylase complex, putative
Similar to S. cerevisiae PHO23; transcriptional regulatory protein PHO23 homologue, putative
transcriptional regulator met32 (methionine-requiring protein 32)
Similar to S. cerevisiae MET31; transcriptional regulator of sulfur amino acid metabolism, putative; transcriptional regulator, putative; zinc finger-containing DNA-binding protein, putative
NAD-dependent glycerol-3-phosphate dehydrogenase, putative
glycerol-3-phosphate dehydrogenase [NAD+], putative
Similar to S. cerevisiae SET2; histone methyltransferase, putative; histone-lysine N-methyltransferase, putative
calcium/calmodulin-dependent protein kinase, putative
In S. cerevisiae: involved in regulation of unsaturated fatty acid biosynthesis; Similar to S. cerevisiae SPT23; protein Spt23 orthologue, putative
spliced gene; Similar to S. cerevisiae NOP3; In S. cerevisiae: RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm
hypothetical LDG family protein, putative
similar to LDG family protein in C. albicans
Similar to S. cerevisiae HEM3; porphobilinogen deaminase, putative; pre-uroporphyrinogen synthase, putative
core RPS block consists of four complete RPS units of 2106bp each, plus one partial RPS unit of 1535bp; orientation = sense
similar to Pichia stipitis IDH1; degraded pseudogene in HOK region of MRS_2
similar to Q59KJ3: ORF in C. albicans Major Repeat Sequence, RB2 region; this gene lies within the RB2 region of MRS_2
cation channel family transporter, putative
DNA repair protein Rad1 homologue, putative
RAD1 endonuclease, component of the nucleotide excision repairosome; Similar to S. cerevisiae RAD1
RecQ-mediated genome instability protein 1 homologue, putative
methylenetetrahydrofolate reductase, putative
autophagy-related protein precursor, putative
malate dehydrogenase, mitochondrial precursor, putative
membrane-bound mettalopeptidase, putative
Located at a synteny breakpoint with C. albicans. The C. albicans positional ortholog (orf19.5370) matches to only the C-terminal half of this protein, but there is a better match to another C. albicans protein (UniProt:Q59RF7
uroporphyrinogen decarboxylase, putative
spliced gene; Similar to S. cerevisiae HEM12
dna repair and recombination protein rdh54, putative
HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 2.1e-06; HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 3.4e-85; HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.2e-20
gene model created based on similarity shown by ACT comparison with C. albicans
UDP-N-acetylglucosamine transferase subunit, putative
Similar to S. cerevisiae ALG14; asparagine linked glycosylation protein, putative
RNA polymerase III subunit C11, putative
origin recognition complex subunit 2, putative
Similar to S. cerevisiae ORC2; origin recognition complex subunit, putative
Similar to S. cerevisiae PRK1; p53-regulating kinase, putative
uncharacterized protein YNL313C orthologue, putative
translation initiation factor 1A, putative
alpha,alpha trehalose-phosphate synthase [UDP-forming] subunit, putative
spliced gene; Similar to S. cerevisiae TPS3; trehalose synthase complex regulatory subunit, putative
Similar to S. cerevisiae TAF8; transcription initiation factor TFIID subunit, putative
ubiquitin domain-containing protein, putative
asymetrically localized transcriptional regulator that controls filamentous growth; Similar to S. cerevisiae ASH1
mRNA transport regulator MTR2 homologue, putative
spliced gene; Similar to S. cerevisiae MTR2
Annotation based on Pfam hit to PF00149, Calcineurin-like phosphoesterase
regulatory protein GAL4 homologue, putative
Similar to S. cerevisiae UBC13; ubiquitin-conjugating enzyme, putative
zinc finger-containing regulatory protein, putative
translational activator GCN1 homologue, putative
regulatory protein Mig1 homologue, putative
Similar to S. cerevisiae MIG1; zinc finger-containing regulatory protein, putative
Similar to C. albicans YRF1, (HPR5); stop codons, partial sequence; appears to be degenerate pseudogene