Caulobacter crescentus NA1000, complete genome.
Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter.
The genetic basis of laboratory adaptation in Caulobacter crescentus
Submitted (15-SEP-2020) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (03-SEP-2016) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St. - GCIS W138, Chicago, IL 60637, USA
Submitted (08-FEB-2014) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St. - GCIS W138, Chicago, IL 60637, USA
Submitted (18-APR-2013) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St. - W138, Chicago, IL 60637, USA
Submitted (11-OCT-2011) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St. - W138, Chicago, IL 60637, USA
Submitted (15-SEP-2010) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St., Chicago, IL 60637, USA
Submitted (28-JUL-2010) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St., Chicago, IL 60637, USA
Submitted (05-JAN-2009) Biochemistry and Molecular Biology, University of Chicago, 929 E. 57th St., Chicago, IL 60637, USA
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CP001340.\nBacterial strain Caulobacter crescentus NA1000 and source genomic\nDNA are available from Crosson Lab, Department of Biochemistry and\nMolecular Biology, The University of Chicago, 929 E. 57th St.,\nChicago, IL 60637.\nCOMPLETENESS: full length.
small RNA regulates the Caulobacter cell cycle according to Beroual, et al. Biorxiv. https://doi.org/10.1101/756452
pyruvate, phosphate dikinase regulatory protein
Maf-family nucleoside triphosphate pyrophosphatase
gene is essential according to Tn-seq experiments of Christen, et al. (2011) Mol Syst Biol. 30;7:528. doi: 10.1038/msb.2011.58
chromosome replication initiator protein DnaA
molybdenum cofactor biosynthesis protein C
molybdenum cofactor biosynthesis protein B
molybdopterin converting factor, large subunit
molybdopterin converting factor, small subunit
molybdenum cofactor biosynthesis protein A
molybdopterin-guanine dinucleotide biosynthesis protein A
putative aerobic-type carbon monoxide dehydrogenase, large subunit CoxL
putative aerobic-type carbon monoxide dehydrogenase, small subunit CoxS
uroporphyrin-III C-methyltransferase/Precorrin-2 dehydrogenase/Sirohydrochlorin ferrochelatase
major facilitator superfamily transporter
ribosome profiling evidence for a possible non-canonical translation start site at nucleotide position 32667
stable processed 3' UTR RNA from CCNA_00033
polyribonucleotide nucleotidyltransferase
protein translation initiation factor 2 IF-2
Transcription termination/antitermination protein NusA
magnesium and cobalt efflux protein CorC
phosphate starvation-inducible protein PhoH
ribosomal-protein-S18-alanine acetyltransferase
tRNA threonylcarbamoyl adenosine modification protein, YeaZ family
mitochondrial-type Fe-S cluster assembly protein NFU
Peptidoglycan biosynthesis protein MviN/MurJ
S-adenosylmethionine-dependent methyltransferase
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
tRNA threonylcarbamoyl adenosine modification protein TsaD
multifunctional fatty acid oxidation complex subunit alpha FadJ
acyl-CoA dehydrogenase, long-chain specific
phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
protein colocalizes with FtsZ at the midcell and is required for proper cell division[doi: 10.15252/embj.201490730]
NAD-specific glutamate dehydrogenase GdhZ
EXISTENCE:ncRNA mapped by tiling arrays experiments of Landt, et al. (2008) Mol Micro. 68;3:600-14. doi: 10.1111/j.1365-2958.2008.06172.x
transporter, drug/metabolite exporter family
required for production of the holdfast polar adhesin[doi: 10.1371/journal.pgen.1004101]
WecG/TagA-family glycosyltransferase HfsJ
2-polyprenyl-6-methoxyphenol hydroxylase
CnoX exhibits constitutive chaperone holdase activity and cooperates wirth GroEL and DnaK according to DOI: 10.1128/mBio.01541-18
MarR/EmrR-family transcriptional regulator
glucosamine-fructose-6-phosphate aminotransferase, isomerizing
O-linked N-acetylglucosamine transferase, SPINDLY family
AmpG-family major facilitator transporter
hybrid two-component histidine kinase/receiver protein ShkA
magnesium chelatase subunit ChlI-like ATPase
SirB1-family tetratricopeptide repeat protein
ribosomal RNA small subunit methyltransferase I
oxygen-independent coproporphyrinogen-III oxidase
Periplasmic serine protease, S1-C subfamily
winged helix-turn-helix transcription repressor HrcA
expression of this small RNA is activated by the ChvI-ChvG two-component system, and acts as a negative regulator of the TonB-dependent receptor CCNA_03108 (ChvT) according to Froehlich, et al. NAR (2018), doi.org/10.1093/nar/gky765
exopolysaccharide transport family protein
stable RNA processed from CDS CCNA_00164
polyisoprenylphosphate hexose-1-phosphotransferase pssY
gene influences capsular polysaccharide composition and is required to render cells heavy according to Ardissone, et al. eLife 2014;3:e03587 DOI: 10.7554/eLife.03587
transglutaminase-like cysteine proteinase HvyA
type II secretory pathway, prepilin signal peptidase
N-acetylglutamate synthase domain protein
3-isopropylmalate dehydratase small subunit
3-isopropylmalate dehydratase large subunit
2OG-Fe(II) oxygenase superfamily protein
glutathione-regulated potassium-efflux system protein kefB
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A
succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B
type 1 glutamine amidotransferase (GATase1)-like domain protein
undecaprenyl-phosphomannose:protein mannosyltransferase
ribosomal-protein-alanine acetyltransferase
thiol:disulfide interchange protein DsbD
thiol-disulfide isomerase and thioredoxin
glucose-6-phosphate isomerase/glucose-6 phosphate 1-epimerase
MhpC-family ACP methyl ester carboxylesterase
CAAX amino terminal protease family protein
ribosomal large subunit pseudouridine synthase B
two-component sensor histidine kinase chvG
pterin-4-alpha-carbinolamine dehydratase
multimodular transpeptidase-transglycosylase PbpX
ribonucleoside-diphosphate reductase beta chain
ketopantoate reductase panE/ApbA family protein
succinyl-diaminopimelate desuccinylase DapE
2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
pyrimidine 5'-nucleotidase family protein
two-component receiver domain protein LovR
photosensory histidine protein kinase LovK
ABC-type sulfate transport system, periplasmic component
autotransporter outer membrane beta-barrel domain-containing protein
phosphate transport system permease protein pstC
phosphate transport system permease protein pstA
phosphate transport ATP-binding protein pstB
phosphate regulon response regulator PhoB
imidazolonepropionase-related amidohydrolase
3-deoxy-D-manno-octulosonic-acid transferase
cobalt-zinc-cadmium resistance protein czcD
phospholipid-lipopolysaccharide ABC transporter
3'-phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase family protein
3-polyprenyl-4-hydroxybenzoate decarboxylase
vegetatible incompatibility protein HET-E-1
FMN-binding nitroreductase family enzyme
monofunctional biosynthetic peptidoglycan transglycosylase MtgA
molybdenum transport system permease protein modB
transporter, major facilitator superfamily
2-oxoglutarate dehydrogenase E1 component
delta 3,5-delta2,4-dienoyl-CoA isomerase precursor
SH3 domain-containing cell surface protein
alpha/beta hydrolase superfamily protein
phosphonates transport ATP-binding protein phnC
phosphonates transport system permease protein phnE
magnesium and cobalt efflux protein corC-like protein
thiol:disulfide interchange protein dsbA
conserved hypothetical cytosolic protein
zinc metallohydrolase, glyoxalase II family
poly(A) polymerase/tRNA-nucleotidyltransferase
type 1 glutamine amidotransferase (GATase1) domain protein
type 1 capsular polysaccharide biosynthesis protein J
stable RNA processed from CDS CCNA_00434
acyl-CoA dehydrogenase, short-chain specific
globin-coupled-sensor methyl-accepting chemotaxis protein
chemotaxis receiver domain protein cheYI
chemotaxis histidine kinase protein cheAI
chemotaxis protein methyltransferase CheRI
receiver domain-glutamate methylesterase cheBI
chemotaxis receiver domain protein cheYII
single domain response regulator protein that binds cyclic-di-GMP and controls flagellum motor function according to Nesper, et al. (2017) eLife 6:e28842 DOI: 10.7554/eLife.28842
N-acetylglucosamine-6-phosphate deacetylase
N-acetyl-glucosamine/N-acetyl-chitin oligosaccharide outer membrane transporter nagA
phosphoenolpyruvate-protein phosphotransferase/phosphocarrier protein HPr/PTS system, glucose-specific IIA subunit
PTS system, N-acetylglucosamine-specific IIBC component
UDP-glucose 6-dehydrogenase related protein
GT1/WbuB-like N-acetyl-L-fucosamine transferase
Undecaprenyl-phosphate sugar phosphotransferase-related protein
UDP glucuronic acid epimerase-related protein
DNA relaxase/conjugal transfer nickase-helicase trwC
bacterial conjugation protein, ATP binding domain trwB
Zn-dependent hydrolase, glyoxalase II family
ribosomal large subunit pseudouridine synthase D
putative polyketide cyclase-dehydrase/lipid transport protein
putative membrane protein insertion efficiency factor YidD
gene disruption leads to loss of smooth LPS and shedding of the protein S-layer according to Hershey et al (2019) DOI: 10.1128/mBio.02273-18
smooth LPS biosynthesis glycosyltransferase
ubiquinol-cytochrome c reductase iron-sulfur subunit
GTP-binding protein, probable translation factor
Abi superfamily/CAAX amino terminal protease
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase
prolipoprotein diacylglyceryl transferase
Polyhydroxyalkanoate synthesis regulator protein
endonuclease/exonuclease/phosphatase family protein
SNARE-associated family membrane protein
sensory transduction protein kinase CenK
glucose-1-phosphatase/inositol phosphatase
trypsin-like peptidase domain family protein
LytR/AlgR-family transcriptional regulator
ribosome profiling and LC-MS experiments provide evidence for a possible non-canonical translation start site at nucleotide position 635026
von Willebrand factor type A domain protein
arginine N-succinyltransferase, beta chain
succinylglutamic semialdehyde dehydrogenase
acetylornithine aminotransferase/succinyldiaminopimelate aminotransferase
methyl-accepting chemotaxis protein McpK
chemotaxis histidine kinase protein cheAII
receiver domain-glutamate methylesterase CheBII
chemotaxis protein methyltransferase CheRII
FhaC-family hemolysin activation/secretion protein
nitrate transport ATP-binding protein nrtD
MFS superfamily nitrate/nitrite transporter NarK
nitrite reductase (NAD(P)H) catalytic subunit
nitrite reductase (NAD(P)H) small subunit
assimilatory nitrate reductase catalytic subunit
type I restriction-modification system methylation subunit
type I restriction-modification system specificity subunit
5-methylcytosine-specific restriction enzyme MRR
type I restriction-modification system restriction subunit
response regulator receiver domain protein
capsular polysaccharide biosynthesis protein
glycosyltransferase family 99 protein WbsX
ABC-type polysaccharide/polyol phosphate transport system, ATPase component
ABC-type polysaccharide/polyol phosphate export system, permease component
2-hydroxychromene-2-carboxylate isomerase
Deoxyribodipyrimidine photo-lyase-related protein
PAS-family hybrid histidine kinase/receiver protein
Studies doi: 10.1038/srep43240 and doi: 10.1371/journal.pgen.1008591 present evidence that this gene is not essential
CarD-family transcriptional regulator CdnL
ribosomal 50S subunit-recycling heat shock protein
gene product confers immunity to CdzCD according to Garcia-Bayona, et al. eLife. 2017; 6: e24869. doi: 10.7554/eLife.24869
gene product, along with CdzC, forms a killing complex according to Garcia-Bayona, et al. eLife. 2017; 6: e24869. doi: 10.7554/eLife.24869
gene product, along with CdzD, forms a killing complex according to Garcia-Bayona, et al. eLife. 2017; 6: e24869. doi: 10.7554/eLife.24869
gene product is involved in secretion of the Cdz killing system, according to Garcia-Bayona, et al. eLife. 2017; 6: e24869. doi: 10.7554/eLife.24869
type I secretion protein CdzA, transmembrane ATPase/peptidase
beta-barrel assembly machine (BAM) protein BamF
DegQ-family trypsin-like serine prototease
riboflavin kinase/FMN adenylyltransferase
oxidative DNA demethylation family protein
ADA regulatory protein/O6-methylguanine-DNA
cyclic-di-GMP phosphodiesterase, flagellum assembly factor TipF
electron transfer flavoprotein alpha subunit
electron transfer flavoprotein beta subunit
cobalamin adenosyltransferase family protein
aminobenzoyl-glutamate transport protein
peptidoglycan-associated outer membrane lipoprotein
tRNA methyltransferase/FAD-dependent oxidoreductase MnmC
FixT binds an Fe-S cluster according to Stein et al (2020) doi: 10.1128/mBio.03383-19
hypoxia negative feedback regulator FixT
Sgt1 functions as a glycosyltransferase, adding a hexose sugar to sphingolipid according to DOI: 10.1128/mBio.00107-19
Sgt1 functions as a glucuronosyltransferase, adding a hexuronic acid to sphingolipid according to DOI: 10.1128/mBio.00107-19
ABC transporter, ATP-binding protein cydC
ABC transporter, ATP-binding protein cydD
cytochrome bd-type quinol oxidase, subunit 1 cydA
cytochrome bd-type quinol oxidase, subunit 2 cydB
inner membrane protein translocase component yidC
flavin-binding monooxygenase-related protein
2-dehydro-3-deoxy-6-phosphogalactonate aldolase
gene is required for growth on proline as a carbon source according to Mouammine et al, Sci Rep 8: 14677 (2018)
proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase PutA
gene activates putA and is required for growth on proline as a carbon source according to Mouammine et al, Sci Rep 8: 14677 (2018)
leucine-responsive regulatory family protein PutR
periplasmic multidrug efflux lipoprotein precursor
HfiA protein functions as a negative regulator of holdfast development[doi: 10.1371/journal.pgen.1004101]
HfiA protein interacts directly with the glycosyltransferase HfsJ[doi: 10.1371/journal.pgen.1004101]
alpha-ketoglutaric semialdehyde dehydrogenase xylA
fumarylacetoacetate hydrolase family protein
DNA modification methyltransferase-related protein
carbon-nitrogen hydrolase family protein
amidophosphoribosyltransferase family protein
expression of this gene is activated by sigT and GsrN under osmotic stress conditions according to Tien et al., J. Bacteriol. (2018) DOI: 10.1128/JB.00349-18
3-demethylubiquinone 3-methyltransferase
stable processed 3' UTR RNA from CCNA_00886
phosphoenolpyruvate-protein phosphotransferase PtsP
rodZ functions as a cell morphogenic gene according to Alyahya, et al (2014) PNAS, https://doi.org/10.1073/pnas.0810794106
helix-turn-helix DNA-binding protein RodZ
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
ribosomal large subunit pseudouridine synthase F
bacterial peptide chain Release factor 1 (RF-1)
inositol ABC transporter, periplasmic inositol-binding protein IbpA
inositol transport ATP-binding protein IatA
inositol ABC transport system, permease protein IatP
exonuclease-endonuclease-phosphatase (EEP1) protein
3-oxoacyl-(acyl-carrier-protein) synthase III
Molybdenum cofactor sulfurase related protein
peptide release factor-glutamine N5-methyltransferase
MarR/EmrR family transcriptional regulator
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
nuclear transport factor 2 family protein
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase MnmA
flagellar hook length determination protein
Basal-body rod modification protein FlgD
organic hydroperoxide resistance protein
Aminoglycoside phosphotransferase family enzyme
protein tyrosine phosphatase family protein
stable RNA processed from CDS CCNA_00974
RND family efflux transporter, MFP subunit
ABC-type transport system involved in lipoprotein release, permease component LolE
ABC-type transport system involved in lipoprotein release, ATPase component LolD
ROS/MUCR transcriptional regulator MucR1
hybrid sensor histidine kinase/receiver protein
Selenocysteine lyase/Cysteine desulfurase
ROS/MUCR transcriptional regulator MucR2
experimental evidence that this protein functions as a pleiotropic regulator of cell cycle and motility [doi: 10.1128/mBio.01415-15]
PAS-family motility and cell cycle regulatory protein MopJ
flagellar hook-basal body complex protein FliE
tryptophan halogenase superfamily protein
putative hexuronate transporter, major facilitator superfamily
peptide methionine sulfoxide reductase msrA
helix-turn-helix transcriptional regulator
type I protein secretion ATP-binding protein RsaD
UDP-perosamine 4-acetyl transferase PerB
type I secretion outer membrane protein RsaFa
deletion of this gene results in sensitivity to sodium dodecyl sulfate (SDS) in Caulobacter; deletion of a homolog of this gene in Brucella abortus results in sensitivity to multiple cell envelope stressors; Brucella gene is synthetically lethal with genes required for O-polysaccharide biosynthesis according to Herrou et al. 2019. doi: 10.1111/mmi.14178.
stable processed 3' UTR RNA from CCNA_01095
phenylalanyl-tRNA synthetase alpha chain
HdaB proteins can interfere with the RIDA process and affect replication frequency in C. crescentus according to doi: 10.1093/nar/gkz1193
two component sensor histidine kinase CckN
sensory transduction histidine kinase/receiver protein CckA
cell surface polysaccharide synthesis protein, GtrA family
stable processed 3' UTR RNA from CCNA_01159
O-linked N-acetylglucosamine transferase
3'-phosphoadenosine 5'-phosphosulfate sulfotransferase
zinc dependent phospholipase C/S1-P1 nuclease-family protein
stable RNA processed from CDS CCNA_01186
gene is required for robust growth in the presence of sucrose as a sole carbon source according to Modrak, et al. (2018), DOI 10.1007/s12275-018-8225-x
transporter, major facilitator superfamily SucD
gene is required for sucrose uptake according to Modrak, et al. (2018), DOI 10.1007/s12275-018-8225-x
gene product represses expression of the adjacent sucrose utilization operon according to Modrak, et al. (2018), DOI 10.1007/s12275-018-8225-x
LacI-family transcriptional regulator SucR
glucose-1-phosphate thymidylyltransferase
UDP-glucuronate decarboxylase family protein
MobA-like NTP transferase domain protein
sphingosine kinase/diacylglycerol kinase-related protein
CcbF functions in ceramide synthesis according to DOI: 10.1128/mBio.00107-19
BioF-family ceramide biosynthesis protein CcbF
glycerophosphotransferase-related protein
ABC-transporter substrate binding protein
Sdp soluble lytic transglycosylase functions are characterized in Zielinska, et al (2017). doi:10.1111/mmi.13775
soluble lytic murein transglycosylase SdpA
cation/multidrug efflux pump, AcrB family
peptidyl-tRNA hydrolase family protein ArfB
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
experimental evidence that this protein functions as an aldose oxidoreductase[doi:10.1007/s00253-015-7011-5]
multidrug resistance transporter, Bcr family
translation elongation factor Tu (EF-TU)
formate dehydrogenase accessory protein fdhD
NAD-dependent formate dehydrogenase alpha subunit
stable processed 3' UTR RNA from CCNA_01324
adenylate kinase/nucleoside-diphosphate kinase
ABC-type multidrug transport system, ATPase component
phosphodiesterase I/nucleotide pyrophosphatase
ribosomal large subunit pseudouridine synthase C
stable RNA processed from CDS CCNA_01347
two-component response regulator protein
myo-inositol-hexaphosphate 3-phosphohydrolase
gene is part of an operon required for utilization of myo-inositol as a carbon and energy source according to Boutte et al (2008) doi: 10.1371/journal.pgen.1000310.
gene encodes a regulator of the myo-inositol utilization operon according to Boutte et al (2008) doi: 10.1371/journal.pgen.1000310.
malonate-semialdehyde dehydrogenase IolA
two-component sensor histidine kinase UrpS
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Fe-S cluster assembly ABC-type transport system, permease and ATPase components
protein-L-isoaspartate O-methyltransferase
type I secretion outer membrane protein rsaFb
tRNA (uracil-5-)-methyltransferase related protein
soluble lytic murein transglycosylase SdpB
uracil DNA glycosylase superfamily protein
electron transfer flavoprotein-ubiquinone oxidoreductase FzeA
tetratricopeptide repeat family protein TtpA
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
ammonium transporter/methylammonium transporter
DNA-binding transcriptional regulator, AcrR family
K(+)-insensitive pyrophosphate energized proton pump
beta-barrel assembly machine (BAM) protein BamE
ubiquinol-cytochrome C reductase chaperone
fatty acid/phospholipid synthesis protein plsX
N-acetyl-gamma-glutamyl-phosphate reductase
fructose-1,6-bisphosphatase, FIG superfamily
single-stranded-DNA-specific exonuclease recJ
electron transport complex I subunit, NADH-ubiquinone oxidoreductase
cytochrome cbb3 oxidase, cytochrome c subunit ccoO
cytochrome cbb3 oxidase, diheme subunit, membrane-bound ccoP
cation pump-linked membrane protein fixH
cytochrome cbb3 oxidase maturation protein ccoS
experimental evidence that this protein functions as an outer membrane channel for cations[DOI: 10.1371/journal.pone.0143557]
OmpW family outer membrane cation channel
oxygen-independent coproporphyrinogen-III oxidase hemN
cyclopropane-fatty-acyl-phospholipid synthase
2-dehydro-3-deoxyphosphooctonate aldolase
cystine transport system permease protein
C4-dicarboxylate transport system, small permease component
C4-dicarboxylate transporter large subunit
NAD(P)H:FMN oxidoreductase family protein
HD family metal-dependent phosphohydrolase
flagellar biosynthesis regulatory protein flaF
sulfate adenylyltransferase subunit 1/adenylylsulfate kinase
D-galactarate dehydratase/Altronate hydrolase
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase
major intrinsic protein (MIP)-family channel protein
2-keto-4-pentenoate hydratase family protein
gene product activity is tied to formation of cell wall 3-3 crosslinked peptides and non-crosslinked tripeptides according to Billini, et al. https://doi.org/10.1101/389114
Glutathione-dependent formaldehyde-activating enzyme
multimodular transpeptidase-transglycosylase PBP 1A
SN-glycerol-3-phosphate transport ATP-binding protein
NADPH-dependent FMN reductase family protein
cell elongation specific D,D-transpeptidase
SEDS-family peptidoglycan polymerase RodA
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
aminobenzoyl-glutamate utilization protein B
pyridoxal phosphate biosynthetic protein pdxJ
2-nitropropane dioxygenase family protein
cyclophilin-type peptidylprolyl cis-trans isomerase
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
osmosensitive K+ channel histidine kinase kdpD
sulfate transport system permease protein cysT
sulfate transport system permease protein cysW
sulfate transport ATP-binding protein cysA
circularly permuted ATP-grasp type 2 protein
outer membrane translocation and assembly protein TamA
autotransporter translocation and assembly factor TamB
putative poly-gamma-glutamate capsule biosynthesis protein
periplasmic glucoside 3-dehydrogenase, cytochrome c2 component
periplasmic glucoside 3-dehydrogenase, lacA subunit
periplasmic glucoside 3-dehydrogenase, lacC subunit
MecR antirepressor / ankyrin repeat family protein
CopY/TcrY family transcriptional repressor
3-methyl-2-oxobutanoate hydroxymethyltransferase
beta-barrel assembly machine (BAM) protein BamB
transporter, sodium/bile acid symporter family
stable processed 3' UTR RNA from CCNA_01739
malonyl-CoA-(acyl-carrier-protein) transacylase FabD
3-oxoacyl-(acyl-carrier protein) reductase
3-oxoacyl-(acyl-carrier-protein) synthase II
4-hydroxythreonine-4-phosphate dehydrogenase
LPS assembly outer membrane protein LptD
LPS export ABC transporter permease LptG
LPS export ABC transporter permease LptF
phosphoribosylglycinamide formyltransferase
phosphoribosylformylglycinamidine cyclo-ligase
hybrid sensor histidine kinase/receiver domain protein
chromosome replication regulator protein HdaA
pyruvate dehydrogenase E1 component alpha subunit
pyruvate dehydrogenase E1 component beta subunit
pyruvate dehydrogenase complex, dihydrolipoamide acetyltransferase component
type II toxin-antitoxin system RatA family toxin
competence/damage-inducible protein CinA
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
nitrogen assimilation regulatory protein NtrC
nitrogen assimilation regulatory protein ntrX
nucleoside triphosphate pyrophosphohydrolase
SalR-family ligand-binding transcriptional regulator
ABC-type transport permease involved in lysophospholipase L1 biosynthesis
acyl-CoA thioesterase I/lysophospholipase
DNA integration/recombination/inversion protein
cytochrome c oxidase assembly protein Surf1
quinol cytochrome oxidase polypeptide IV
quinol cytochrome oxidase polypeptide III
quinol cytochrome oxidase polypeptide II
magnesium and cobalt transport protein corA
NADH:flavin oxidoreductase, old yellow enzyme family
3-ketoacyl-(acyl-carrier-protein) reductase FabG
NAD-binding Rossmann superfamily protein
IclR family HTH transcriptional regulator
enoyl-CoA hydratase/isomerase family protein
ABC-type transporter, permease component
ABC transporter substrate-binding protein
16S rRNA m(2)G 1207 methyltransferase RsmC
ribosomal small subunit pseudouridine synthase A
transcription-repair coupling factor Mfd
1-acyl-sn-glycerol-3-phosphate acyltransferase
Iron-sulfur cluster assembly accessory protein
cysteine desulfurase/selenocysteine lyase
cysteine desulfhydrase/Selenocysteine lyase
lytM-family Ldp gene functions are characterized in Zielinska, et al (2017). doi:10.1111/mmi.13775
M23 family peptidoglycan-specific endopeptidase LdpA
multimodular transpeptidase-transglycosylase PbpY
AmiC is characterized in Zielinska, et al (2017). doi:10.1111/mmi.13775
ThiaminS ubiquitin-like sulfur carrier protein ThiS
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
leucyl/phenylalanyl-tRNA--protein transferase
NADH:ubiquinone oxidoreductase subunit NDUFA12
vitamin B12-dependent ribonucleotide reductase
this gene can be successfully deleted using a directional knockout approach according to studies of Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
the pentapeptide repeat gene product, named PerA by the authors, is required for cdz toxin-dependent killing according to Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
this gene product localizes almost exclusively to the outer membrane of Caulobacter cells according to Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
pentapeptide envelope resistance protein
anthranilate synthase component II/para-aminobenzoate synthase glutamine amidotransferase component II
DNA translocation competence protein ComA
Flagellar hook-length control protein FliK
biochemical function of this protein in the lipid A biosynthetic pathway has been defined by Metzger and Raetz (2010) Biochemistry 49: 6715-6726.
UDP-2,3-diacylglucosamine pyrophosphatase LpxI
UDP-N-acetylglucosamine O-acyltransferase LpxA
(3R)-hydroxymyristoyl-ACP dehydratase FabZ
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase LpxD
beta-barrel assembly machine (BAM) protein BamA
1-deoxy-D-xylulose 5-phosphate reductoisomerase
translation elongation factor Ts (EF-Ts)
stable processed 5' UTR RNA from CCNA_02000
SOS-induced inhibitor of cell division SidA
inosine-uridine nucleoside N-ribohydrolase
lipoprotein releasing system ATP-binding protein lolD
lipoprotein releasing system transmembrane protein lolE
pantothenate kinase/Bvg accessory factor
Cytochrome bd-type quinol oxidase, subunit 2-like protein
CRISPR/Cas system endoribonuclease Cas6-like protein
ATP-dependent endopeptidase clp, ATP-binding subunit ClpX
ATP-dependent endopeptidase clp, proteolytic subunit ClpP
imidazolonepropionase related amidohydrolase
methylmalonyl-CoA carboxylase, carboxyltransferase subunit
conserved hypothetical protein, YnfA/UPF0060 family
beta-barrel assembly machine (BAM) protein BamD
UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase
phytoene/squalene synthase family protein
peptidoglycan binding endopeptidase DipM
5'(3')-nucleotidase/polyphosphatase SurE
Sec-independent protein translocase protein tatC
Sec-independent protein translocase protein tatB
Sec-independent protein translocase protein tatA
chromosome segregation and condensation protein B scpB
chromosome segregation and condensation protein fusion scpA
anhydromuramoyl-peptide exo-beta-N-acetylglucosaminidase
deoxyguanosinetriphosphate triphosphohydrolase
iron-sulfur cluster insertion protein ErpA
NAD/NADH-dependent eicosanoid dehydrogenase
MdoH-family membrane glycosyltransferase
Type 1 glutamine amidotransferase domain protein
TolB protein precursor/tail-specific protease
pilF-related tetratricopeptide repeat protein
polyketide cyclase/lipid transport protein
ligase-associated DNA damage response DEXH box helicase
ligase-associated DNA damage response endonuclease
bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
polar flagellum positioning protein pflI
flagella basal body P ring formation protein flgA
calcium-binding RTX toxin-related protein
glutamate dehydrogenase/leucine dehydrogenase
long-chain fatty acid transport protein precursor
iron-sulfur cluster assembly/repair protein ApbC
phosphatase/phosphohexomutase family protein
tRNA delta(2)-isopentenylpyrophosphate transferase
competence damage-inducible protein cinA
tmRNA ssrA acceptor RNA mature 5' fragment
tmRNA ssrA acceptor RNA mature 3' fragment
adapter for ClpXP proteolysis of tmRNA-tagged proteins SspB
ketol-acid reductoisomerase/2-dehydropantoate 2-reductase
SMP-30/gluconolactonase/LRE family protein
old yellow enzyme (OYE)-family NADH:flavin oxidoreductase
5-methyltetrahydrofolate--homocysteine methyltransferase homocysteine-binding subunit
CAU/MBL1b family subclass B3 metallo-beta-lactamase
ArsR family/SAM-dependent transcriptional regulator
Peptidogalycan biosysnthesis/recognition protein
glycerophosphoryl diester phosphodiesterase
D-alanyl-D-alanine serine-type carboxypeptidase CrbA
methylcrotonyl-CoA carboxylase biotin-containing subunit
methylcrotonyl-CoA carboxylase carboxyl transferase subunit
hybrid CAP effector domain/patatin phospholipase protein
lysozyme-family localization factor spmX
propionyl-CoA carboxylase biotin-containing subunit
Type 1 glutamine amidotransferase (GATase1)-like protein
peptide methionine sulfoxide reductase msrB
stable RNA processed from CDS CCNA_02265
gene encodes the outer membrane component of a hemin/hemoglobin utilization system according to Balhesteros, et al. (2016) J Bacteriol 199:e00723-16. https://doi.org/10.1128/JB.00723-16.
TonB-dependent outer membrane channel HutA
demethoxyubiquinone hydroxylase family protein
tRNA synthetase class I, catalytic domain protein
thiol:disulfide interchange protein tlpA
hypoxanthine-guanine phosphoribosyltransferase
gene is required for pilus biogenesis according to Mignolet, et al. eLife 2016;5:e18647 DOI: 10.7554/eLife.18647
zinc-finger pilus regulatory protein ZitP
prephenate/arogenate dehydrogenase family protein
2'-deoxycytidine 5'-triphosphate deaminase
aspartate aminotransferase family protein
stable processed 3' UTR RNA from CCNA_02328
M23 family peptidoglycan-specific endopeptidase LdpB
lipid A biosynthesis lauroyl acyltransferase
transcriptional regulator of stalk biogenesis staR
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
xanthine dehydrogenase family protein molybdopterin-binding subunit
membrane-bound aldehyde dehydrogenase iron-sulfur protein
phosphohydrolase, MutT/nudix family protein
CoA-acylating methylmalonate-semialdehyde dehydrogenase
gene is required for synthesis of the holdfast according to Hershey, et al. (2019) mBio; doi: 10.1128/mBio.02273-18.
holdfast glycosyl transferase family 2 protein HfsL
cytoplasmic membrane maltose transporter malY
TonB-dependent maltose outer membrane transporter malA
glucosamine-1-phosphate acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase
ABC membrane transporter, periplasmic component
membrane integrity-associated transporter subunit PqiC
stable processed 3' UTR RNA from CCNA_02412
this transcription factor is activated by SpdR and directly represses hfiA transcription according to Reyes-Ruiz et al (2019) doi:10.1371/journal.pgen.1008022
putative DNA modification/repair radical SAM protein
low molecular weight phosphatase family protein
NCS1 family nucleobase:cation symporter-1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
glutathionylspermidine synthase family protein
stable processed 5' UTR RNA from CCNA_02452
hydantoinase B/oxoprolinase family protein
nitropropane dioxygenase/trans-enoyl-CoA reductase family protein
UDP-glucose/GDP-mannose dehydrogenase family protein
polyisoprenylphosphate hexose-1-phosphotransferase pssZ
type II toxin-antitoxin system HipA family toxin
cobalt-zinc-cadmium resistance protein czcC
cobalt-zinc-cadmium resistance protein czcB
cobalt-zinc-cadmium resistance protein czcA
vanillate demethylase oxygenase subunit A vanA
vanillate demethylase oxidoreductase subunit vanB
NAD-dependent benzaldehyde dehydrogenase II
acetate/3-ketoacid CoA transferase, subunit A
acetate/3-ketoacid CoA transferase, subunit B
protocatechuate 3,4-dioxygenase beta chain
protocatechuate 3,4-dioxygenase alpha chain
3-carboxy-cis,cis-muconate cycloisomerase
3-oxoadipate enol-lactonase/4-carboxymuconolactone decarboxylase
putative 3-(3-hydroxy-phenyl)propionate transporter
Spd soluble lytic transglycosylase functions are characterized in Zielinska, et al (2017). doi:10.1111/mmi.13775
type IV secretory pathway, VirB2 protein
type IV secretory pathway, VirB3 protein
type IV secretory pathway, VirB6 channel protein
type IV secretory pathway, VirB9 channel protein
type IV secretory pathway, VirB10 channel protein
type IV secretory pathway, VirB11 ATPase
polyisoprenylphosphate hexose-1-phosphotransferase hfsE
oligosaccharide translocase/flippase hfsF
polysaccharide autokinase-related protein hfsB
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A
aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
PlsY-like acyl-phosphate glycerol 3-phosphate acyltransferase
DNA recombination-mediator protein A, SMF family
aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
response regulator receiver protein DivK
ATP-dependent Clp protease adaptor protein ClpS
ATP-dependent clp protease ATP-binding subunit ClpA
sensory transduction histidine kinase pleC
methylmalonyl Co-A mutase-associated GTPase
aimB is reported to be an essential gene by Werner et al (2020) https://doi.org/10.1016/j.bpj.2020.04.029
AimB is reported to inhibit assembly of MreB actin by Werner et al (2020) https://doi.org/10.1016/j.bpj.2020.04.029
phosphoribosylamidoimidazole-succinocarboxamide synthase
phosphoribosylformylglycinamidine synthase, purS component
phosphoribosylformylglycinamidine synthase I
phosphoribosylformylglycinamidine synthase II
Zn finger TFIIB-family transcription factor
glutathione-dependent formaldehyde dehydrogenase
stable processed 3' UTR RNA from CCNA_02607
stable processed 3' UTR RNA from CCNA_02624
UDP-N-acetylenolpyruvoylglucosamine reductase
stable RNA processed from CDS CCNA_02629
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
SEDS-family peptidoglycan polymerase FtsW
UDP-N-acetylmuramoylalanine--D-glutamate ligase
phospho-N-acetylmuramoyl-pentapeptide- transferase
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase
UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
stable RNA processed from CDS CCNA_02643
PBP2-family ligand-binding transcriptional regulator
N-acetyl-anhydromuramyl-L-alanine amidase
drug/metabolite transporter (DMT) family protein
crotonase/enoyl-CoA hydratase family protein
pyridoxamine 5'-phosphate oxidase family protein
stable RNA processed from CDS CCNA_02663
chemotactic signal-response protein CheL
stable RNA processed from CDS CCNA_02669
cyclopropane fatty acid synthase-like protein
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
YceI-family polyisoprenoid-binding protein
xanthine dehydrogenase accessory protein XdhC
rhomboid family intramembrane serine protease
ABC-F family ATP-binding cassette domain-containing protein
gene is required for attachment of the holdfast to the cell according to Hershey, et al. (2019) mBio; doi: 10.1128/mBio.02273-18.
NADPH-dependent 7-cyano-7-deazaguanine reductase QueF
Rve-family integrase core domain protein
GAF/PAS-family histidine kinase/receiver protein
adenylate/guanylate cyclase domain-containing protein
lasso peptide isopeptide bond-forming cyclase
ribosome profiling experimental evidence for a possible non-canonical translation start site at nucleotide position 2956119
HTH/XRE-family transcriptional regulator
efflux RND transporter periplasmic adaptor subunit
CusA/CzcA family heavy metal efflux RND transporter
hipA-related phosphatidylinositol 3/4-kinase
sulfoxide reductase heme-binding subunit protein
sulfoxide reductase catalytic subunit protein
glutamate-ammonia-ligase adenylyltransferase
stable RNA processed from CDS CCNA_02841
type II toxin-antitoxin system toxin protein parE3
type II toxin-antitoxin system antitoxin protein parD3
stable processed 3' UTR RNA from CCNA_02846
cytochrome c-type biogenesis protein ccmH
cytochrome c-type biogenesis heme chaperone
cytochrome c-type biogenesis protein ccmI
PepSY peptidase propeptide domain protein
hipA-family phosphatidylinositol 3/4-kinase
glycoside hydrolase TIM-barrel-like domain-containing protein
GTA glycoside hydrolase TIM-barrel domain protein
Putative phage NlpC/P60 cell wall-associated hydrolase
phage-derived conserved hypothetical protein
phage gp6-like head-tail connector protein
phage phi-C31 gp36 major capsid-like protein
glyoxalase/bleomycin resistance protein, dioxygenase superfamily
very short patch repair (Vsr) endonuclease
cbb3-type cytochrome C oxidase, subunit III
FKBP-type peptidyl-prolyl cis-trans isomerase
bifunctional D-altronate/D-mannonate dehydratase
tetratricopeptide repeat-containing 2OG-Fe(II) oxygenase
carbamoyl-phosphate synthase small chain
alcohol dehydrogenase catalytic domain-containing protein
mitochondrial fission ELM1 family protein
spsG-related polysaccharide biosynthesis protein
S-adenosylmethionine-dependent methyltransferase related protein
Protoporphyrinogen oxidase-related protein
beta-1,6-N-acetylglucosaminyltransferase-related protein
SDR family NAD(P)-dependent oxidoreductase
sulfite exporter TauE/SafE family protein
NeuB-family N-acetylneuraminate synthase
type II toxin-antitoxin system HicB family antitoxin
CwlJ-family cell wall hydrolase family protein
non-specific DNA-binding protein Dps/iron-binding ferritin-like antioxidant protein/ferroxidase
RNA polymerase ECF-type sigma factor sigU
aminotransferase class V-fold PLP-dependent enzyme
carbamoyl-phosphate synthase large chain
patatin family phospholipase domain protein
putative DNA-binding domain-containing protein
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
DNA-binding transcriptional regulator, CsgD family
cytochrome b/b6 domain-containing protein
phosphatidylinositol-specific phospholipase C1-like protein
branched-chain amino acid aminotransferase
3-deoxy-manno-octulosonate cytidylyltransferase
ribosome profiling and LC-MS evidence for a possible non-canonical translation start site at nucleotide position 3188063
TadC-related pilus assembly protein CpaH
TadB-related pilus assembly protein CpaG
outer membrane pilus secretion channel CpaC
CpaC-related secretion pathway protein CpaI
TadG-related pilus assembly protein CpaJ
TadE-related pilus assembly protein CpaK
aminodeoxychorismate synthase, component I
Arc/MetJ-family transcriptional regulator
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
protein has been defined as a redox-regulated cell cycle control protein[doi: 10.1101/gad.257030.114]
redox cell cycle regulatory protein NstA
small-conductance mechanosensitive channel
alkylphosphonate utilization operon protein PhnA
expression of this protein is repressed by the small RNA ChvR according to Froehlich, et al. NAR (2018), doi.org/10.1093/nar/gky765
TonB-dependent outer membrane receptor ChvT
mrrA deletion results in several behavioral and growth defects, according to Lori, et al. (2018) mBio, DOI: 10.1128/mBio.00809-18. mrrA is homologous to sdrG of Sphingomonas melonis described in PNAS (2014) 111:E5196-E5204. doi:10.1073/pnas.1410095111
magnesium and cobalt efflux protein corB
membrane-associated phospholipid phosphatase
phospholipase C, phosphocholine-specific
M23 family peptidoglycan-specific endopeptidase LdpD
type II toxin-antitoxin system antitoxin HigA
type II toxin-antitoxin system toxin HigB
ribosome profiling evidence for a possible non-canonical translation start site at nucleotide position 3285799
PAS-family sensor histidine kinase/receiver protein
sulfite reductase (NADPH) flavoprotein alpha-component
bifunctional ornithine acetyltransferase/N-acetylglutamate synthase
hydrophobic ligand-binding SRPBCC domain protein
carboxymuconolactone decarboxylase family protein
ARO8 family aminotransferase/HTH DNA-binding protein
ring hydroxylating dioxygenase, alpha-subunit
basic amino acid/polyamine antiporter (APA) family transporter
TPR repeat sulfotransferase family protein
stable RNA processed from CDS CCNA_03230
gamma-glutamyl-gamma-aminobutyrate hydrolase family protein
spermidine/putrescine transport ATP-binding protein potA
spermidine/putrescine transport system permease protein potC
ABC-type spermidine/putrescine transport system, permease component II
glutamate-1-semialdehyde 2,1-aminomutase
NAD-dependent succinate-semialdehyde dehydrogenase
NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
EAL-domain diguanylate phosphodiesterase
MarR-family HTH transcriptional regulator / N-acyltransferase
CopY/TcrY-family transcriptional regulator
type II toxin-antitoxin system PemK/MazF family toxin
CBS pair-family sensor histidine kinase/receiver domain protein
gene is is involved in degradation of branched-chain amino acids according to Irnov, et al. Plos Genet 2017, https://doi.org/10.1371/journal.pgen.1006978
type II toxin-antitoxin system HicA family toxin
WecE-family pyridoxal phosphate-dependent enzyme
stable processed 3' UTR RNA of CCNA_03303
transcription antitermination protein NusG
UDP-N-acetylglucosamine 4,6-dehydratase/UDP-D-quinovosamine 4-dehydrogenase
DNA polymerase III alpha subunit DnaE2/ImuC
phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase
Tol-Pal system periplasmic component YbgF
peptidoglycan-associated lipoprotein pal
tol-pal system-associated acyl-CoA thioesterase
FtsW/RodA/SpoVE family cell cycle protein
crossover junction endodeoxyribonuclease ruvC
Dipeptidyl aminopeptidase/acylaminoacyl peptidase
glyceraldehyde 3-phosphate dehydrogenase
Cannot be deleted in the presence of an intact sigF gene, a double sigF-nrsF mutant is viable according to doi: 10.1186/1471-2180-12-210.
ECF-family RNA polymerase sigma factor SigF
chemotaxis receiver domain protein CheYIII
RNA polymerase sigma factor, SigJ family
SuhB-family inositol monophosphatase protein
ABC transporter ATP-binding protein/permease
stable processed 3' UTR RNA from CCNA_03384
multimodular transpeptidase-transglycosylase PbpC
ABC transporter ATP-binding cassette domain protein
phosphoribosylaminoimidazole carboxylase ATPase subunit
phosphoribosylcarboxyaminoimidazole (NCAIR) mutase
NAD(P)H quinone oxidoreductase, PIG3 family
M23 family peptidoglycan-specific endopeptidase LdpE
NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta
Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha
aa3 type cytochrome c oxidase subunit IV-related protein
GapR protein binds AT-rich regions of the chromosome according to Ricci et al. PNAS doi: 10.1073/pnas.1612579113
GapR protein stimulates gyrase and topo IV to relax positive supercoils according to Guo at al. Cell doi:https://doi.org/10.1016/j.cell.2018.08.029
membrane-bound lytic murein transglycosylase B
YcaQ-family winged helix DNA-binding protein
peptidoglycan binding domain/FecR protein
horizontally transferred transmembrane domain (HTTM) protein
UDP-glucose 6-dehydrogenase-related protein
glycine cleavage system protein P, C-terminal domain
glycine cleavage system protein P, N-terminal domain
glycine cleavage system aminomethyltransferase GcvT
zinc-dependent metalloprotease, MMP subfamily 2
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
type II toxin-antitoxin system doc family toxin
SpoVT-AbrB family transcription factor, phd antitoxin
triphenylmethane reductase (TMR)-like protein
NfeD-related membrane protease regulator
membrane protease family, stomatin/prohibitin-like protein
zonular occludens toxin, zot-like protein
gluconate 5-dehydrogenase (Ga5DH)-related protein
ADP-ribose pyrophosphatase, nudix family
ribosomal-protein-S5-alanine acetyltransferase
stable processed 3' UTR RNA from CCNA_03513
cytochrome c oxidase assembly protein ctaG
cytochrome c oxidase polypeptide II coxB
biochemical fractionation studies indicate the ZerA protein is localized to the inner membrane, Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
induced expression of ZerA conferes resistance to the Cdz killing system, Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
biochemical fractionation studies indicate the ZerB protein is localized to the inner membrane, Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
induced expression of ZerB conferes resistance to the Cdz killing system, Garcia-Bayona (2019) doi: 10.1128/JB.00538-18
multidrug resistance ABC transporter, ATP-binding and permease components
gene expression is induced by SOS response system[http://dx.doi.org/10.1016/j.dnarep.2015.06.009]
NAD-dependent epimerase/dehydratase family protein
nicotinate-nucleotide adenylyltransferase
M23 family peptidoglycan-specific endopeptidase LdpF
gene expresion is induced by SOS response system[http://dx.doi.org/10.1016/j.dnarep.2015.06.009]
3'(2'),5'-bisphosphate nucleotidase CysQ
chemotaxis receiver domain protein CheYIV
chemotaxis protein methyltransferase CheRIII
two-component sensor histidine kinase PhyK
RNA polymerase EcfG family sigma factor sigT
anti-anti sigma factor/receiver protein PhyR
two-component sensor histidine kinase DivL
ribonucleoside-diphosphate reductase alpha chain
HTH XRE-family transcriptional regulator
sodium-dependent bicarbonate transport family permease
ATP phosphoribosyltransferase regulatory subunit
phenylpropionate dioxygenase ferredoxin reductase subunit
succinate dehydrogenase iron-sulfur protein
succinate dehydrogenase flavoprotein subunit
succinate dehydrogenase membrane anchor subunit
succinate dehydrogenase cytochrome b556 subunit
tRNA A37 threonylcarbamoyladenosine biosynthesis protein
Caulobacter amgK and murU are functional by complementation of the fosfomycin susceptibility phenotype of the Pseudomonas putida amgK and murU mutants according to Gisin et al. 2013. Nature Chemical Biology 9:491-493
N-acetylmuramate/N-acetylglucosamine kinase AmgK
N-acetylmuramate alpha-1-phosphate uridylyltransferase MurU
folylpolyglutamate synthase/dihydrofolate synthase
acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
N-(5'-phosphoribosyl)anthranilate isomerase
4-hydroxy-tetrahydrodipicolinate reductase
gene encodes a small RNA that is a post-transcriptional regulator of gene expression; gene confers resistance to multiple stressors including hydrogen peroxide and hyperosmotic conditions according to Tien, et al, eLife 2018;7:e33684. DOI: 10.7554/eLife.33684
this hybrid histidine kinase directly interacts with the sensor kinases, SpdS and LovK according to Reyes-Ruiz et al (2019) doi:10.1371/journal.pgen.1008022
multimodular transpeptidase-transglycosylase PbpZ
alpha2 macroglobulin domain-containing extracellular protein
SpsF-family polysaccharide biosynthesis protein
xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family
sigma-54-dependent Fis family transcriptional regulator
large-conductance mechanosensitive channel
3-phosphoshikimate 1-carboxyvinyltransferase
ExoD-family ABC transport membrane permease
LPS export ABC transporter ATP-binding protein
LptC-related lipopolysaccharide assembly protein
glutamate synthase (NADPH) small chain GltD
glutamate synthase (NADPH) large chain GltB
dTDP-4-amino-4,6-dideoxygalactose transaminase, WecE family
small-conductance mechanosensitive channel mcsS
ManA is a phosphomannose isomerase that affects phosphate metabolism, cellular envelope biosynthesis, and entry into stationary phase according to DOI: 10.1128/JB.00468-19
hybrid histidine kinase/receiver domain protein
UTP-glucose-1-phosphate uridylyltransferase
bifunctional D-glycero-D-manno-heptose-7-phosphate 1-kinase/D-glycero-D-manno-heptose-1-phosphate adenylyltransferase
citrate lyase beta chain/citryl-CoA lyase subunit
Bacterial BAX inhibitor (BI)-1/YccA-like protein
cytochrome c biogenesis ATP-binding export protein CcmA
cytochrome c biogenesis ABC transporter permease component CcmB
tRNA 2-methylthioadenosine synthase-like protein
gene product is predicted to modify holdfast polysaccharide, and is required for the development of a fully adhesive holdfast according to Sprecher, et al. mBio. DOI: 10.1128/mBio.00294-17
GNAT-family holdfast biogenesis protein HfsK
organic solvent resistance transport system Ttg2D protein
organic solvent resistance transport system Ttg2C protein
organic solvent resistance transport system permease
organic solvent resistance transport system ATP-binding protein
LysR-family transcriptional regulator OxyR
intermediate filament-like cell shape determinant creS
LolA-family outer membrane lipoprotein carrier protein
ubiquinone/menaquinone biosynthesis methyltransferase UbiE
2-polyprenylphenol 6-hydroxylase accessory protein UbiB
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
deoxyuridine 5'-triphosphate nucleotidohydrolase
enoyl-(acyl-carrier protein) reductase FabI
3-oxoacyl-(acyl-carrier-protein) synthase
3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase
gluconate 2-dehydrogenase/glyoxylate reductase/hydroxypyruvate reductase
ATP-dependent endopeptidase hsl proteolytic subunit HslV
ATP-dependent endopeptidase hsl ATP-binding subunit HslU
ADA regulatory protein/O6-methylguanine-DNA methyltransferase
imidazole glycerol phosphate synthase, glutamine amidotransferase subunit
phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase
imidazole glycerol phosphate synthase, cyclase subunit
membrane-bound lytic murein transglycosylase A
pyridoxal 5'-phosphate dependent enzyme class III
tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase