Lachancea thermotolerans CBS 6340 chromosome H complete sequence.
Lachancea thermotolerans CBS 6340 (Kluyveromyces thermotolerans CBS 6340)
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
Comparative genomics of protoploid Saccharomycetaceae
Submitted (05-JUN-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (04-JUN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CU928180.\nThe Lachancea thermotolerans sequence is made of 8 chromosomes (A\nto H). The sequence was annotated by the Genolevures Consortium.\nFor more information go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF
similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family
similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria
some similarities with uniprot|P53857 Saccharomyces cerevisiae YNL234W similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p
weakly similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor
similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy
similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis
highly similar to uniprot|P11412 YNL241C Saccharomyces cerevisiae ZWF1 Glucose-6-phosphate dehydrogenase
similar to uniprot|P23503 YNL240C Saccharomyces cerevisiae NAR1 Nuclear architecture related protein component of the cytosolic iron-sulfur (FeS) protein assembly machinery
similar to uniprot|P13134 YNL238W Saccharomyces cerevisiae KEX2 Subtilisin-like protease (proprotein convertase)
similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W YTP1
similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription
highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta
highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase acetylates lysine 14 on histone H3 catalytic subunit of the ADA and SAGA histone acetyltransferase complexes founding member of the Gcn5p-related N-acetyltransferase superfamily
similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes
highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability
highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly
some similarities with uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation
similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition
highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing
similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate
some similarities with uniprot|P53316 Saccharomyces cerevisiae YGR250C Hypothetical ORF
some similarities with uniprot|P53050 Saccharomyces cerevisiae YGR249W MGA1 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W SOL3 Glucose-6-phosphate dehydrogenase weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p
similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43
highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
similar to uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin
similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB
similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression
similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1 UGA2 UGA4) zinc- finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type localized to the nucleus
similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF
similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
DNA transposon of KLTH part of the newly discovered ROVER DNA transposon family of the Kluyveromyces:degenerate copy
similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1
weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 Protein of unknown function
highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA
similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C Hypothetical ORF
similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene
similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53
highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase)
some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1
similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response
highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor
similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA
similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme
similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination
some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1
weakly similar to uniprot|Q3E829 Saccharomyces cerevisiae YDL160c-a
weakly similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles
similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides
similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation
similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway
similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF
similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF
similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF
similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2-specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3
similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre- 18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing
similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53
similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre-autophagosomal structure and other cytosolic punctate structures not found in autophagosomes
similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre-18S rRNA
highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid
weakly similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF
similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck
similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway
similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C CRR1 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers
similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels
similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123
highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo
similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function
similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase
highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C
similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity
some similarities with uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation
similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF
similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles
similar to uniprot|P10870 Saccharomyces cerevisiae YDL194W SNF3 glucose sensor
similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1
highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W ARF1 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf2p
highly similar to uniprot|P19146 Saccharomyces cerevisiae YDL137W ARF2 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf1p
highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit
similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex
some similarities with uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain
highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor
highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C PPH21 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph22p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis
some similarities with uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF
uniprot|Q8J0L0 VMA1 Putative vacuolar membrane H-ATPase
similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF
similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W
similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase
some similarities with uniprot|P01097 Saccharomyces cerevisiae YDL181W
similar to uniprot|Q3E7A9 Saccharomyces cerevisiae YMR194C-B
highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit
mitochondrial 54S ribosomal protein YmL24/YmL14
similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit
weakly similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p involved in ER to Golgi trafficking interacts with the yeast amphiphysins Rvs161p and Rvs167p
weakly similar to uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources
weakly similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose repressed by Gal80p and activated by Gal3p
similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity
similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide
highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm
similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF
mitochondrial 37S ribosomal protein MRPS17
similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF
similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP- galactose transport to the Golgi lumen
similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane
similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p
weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl
highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family
similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability
similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1
similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon
weakly similar to uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF
similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Hypothetical ORF
highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue
highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'
similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation
highly similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W SSO1 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE
highly similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities
some similarities with uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF
highly similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase
similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum
weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2 but not required at the other histone loci functionally related to Spt10p
similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU]
similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF
similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF
similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p
similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks
weakly similar to uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein expression is increased in response to heat-shock stress or treatments that produce DNA lesions
weakly similar to uniprot|Q03213 Saccharomyces cerevisiae YMR172W
similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria
weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria
similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation
weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C Hypothetical ORF
similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer
similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit
weakly similar to uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate
highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport
similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p
similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a-specific genes repression of early meiotic genes during mitotic growth and repression of INO1
similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex
similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities
weakly similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein
similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2
similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit
mitochondrial 37S ribosomal protein RSM23
similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis; intranuclear protein which exhibits a nucleotide-specific intron-dependent tRNA pseudouridine synthase activity
highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis
similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane
similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function
similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate
similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W Hypothetical ORF
similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W Hypothetical ORF
similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2-PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation
some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex
similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function
similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes
similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta)
highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit
putative mitochondrial 54S ribosomal protein MNP1
similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid
highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site
similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements
weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p
similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF
highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit
similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo- inositol
similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide
similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF
similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP- 3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex
similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA-like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate
similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly
some similarities with uniprot|P53156 Saccharomyces cerevisiae YGL081W Hypothetical ORF
similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs
similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p
similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant
similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C GUP1 Multimembrane-spanning protein and similar to uniprot|Q08929 Saccharomyces cerevisiae YPL189W GUP2
similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF
similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p
highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Protein involved in error-free postreplication DNA repair forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity cooperates with chromatin-associated RING finger proteins Rad18p and Rad5p
highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD() with lower specificity required for the response to oxidative stress
similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes
similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor
some similarities with uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein of unknown function
similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF
weakly similar to uniprot|P53150 Saccharomyces cerevisiae YGL090W LIF1 Protein involved in DNA double-strand break repair physically interacts with DNA ligase 4 (Lig4p) homologous to mammalian XRCC4 protein
highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta
similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex
weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105
some similarities with uniprot|O14464 Saccharomyces cerevisiae YPL183W-A
similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF
similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One
similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p
similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain
similar to uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase null mutation enhances efficiency of translational suppressors
highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif
some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin-dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription
weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W Hypothetical ORF
similar to uniprot|P38156 Saccharomyces cerevisiae YBR298C MAL31 Maltose permease high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL3 complex locus member of the 12 transmembrane domain superfamily of sugar transporters functional in genomic reference strain S288C
similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C Hypothetical ORF
highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase
highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor
similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p
similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus
similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability
similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions
highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm
similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF
highly similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation
highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor or similar to YBR244W uniprot|P38143 Saccharomyces cerevisiae YBR244W GPX2 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p
similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin
similar to uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF or YGL101W uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF
highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein L29 of the large (60S) ribosomal subunit
similar to uniprot|P53142 Saccharomyces cerevisiae YGL104C VPS73 Mitochondrial protein involved in vacuolar protein sorting
similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes
similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids
similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF
similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF
similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family
highly similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF
similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination
similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis
highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore
highly similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes
weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1
similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W
similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters
highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 involved in release from glucose repression invertase expression and sporulation associates with Snf1p
similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate
similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; has similarity to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome
some similarities with uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA
highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2
some similarities with uniprot|P38325 Saccharomyces cerevisiae YBR230C Hypothetical ORF
similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt- vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate
some similarities with uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations
similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p
similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1
weakly similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF
highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase
highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60
highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex which is an evolutionarily-conserved multi-protein complex found in mitochondria
similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF
weakly similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy
similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Subunit of the RNA polymerase II mediator complex
highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase
similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis
similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy
similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2
some similarities with uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes
similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF
highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
some similarities with uniprot|P53171 Saccharomyces cerevisiae YGL057C Hypothetical protein
similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations
uniprot|P79047 Delta 9-fatty acid desaturase
similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase
some similarities with uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein
some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability
similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud- site selection protein Axl2p to cell surface related to Drosophila cornichon
similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF
weakly similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain
highly similar to uniprot|P23776 YLR300W Saccharomyces cerevisiae EXG1 Major exo-1 3-beta-glucanase of the cell wall
similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p- MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4
similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation
highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans
some similarities with uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing
some similarities with uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase
some similarities with uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase required for high level expression of both the THI and the PDC genes
similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex
similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane
highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF
similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence
similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient
weakly similar to uniprot|P10355 Saccharomyces cerevisiae YER153C PET122 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p located in the mitochondrial inner membrane
similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity
some similarities with uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin
some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077W SED1 Isolated as a suppressor of an erd2 deletion mutant (ERD2 is the HDEL receptor that sorts ER proteins) SED1 encodes a cell wall protein.
weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p
highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization
weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis cell fusion
highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability
similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4
similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6-phosphate phosphatase
some similarities with uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex
similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay
highly similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation
similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P32571 Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin hydrolase required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
weakly similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control
similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase
similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF
similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF
similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF
highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF
highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP- binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
weakly similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N-linked and O-linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family
highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay
weakly similar to uniprot|P40083 Saccharomyces cerevisiae YER137C
similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit
similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W
similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
similar to uniprot|P38067 Saccharomyces cerevisiae YBR006w UGA2 succinate semialdehyde dehydrogenase involved in the utilization of gamma- aminobutyrate (GABA) as a nitrogen source
similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria
similar to uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme-activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences contributing to both complex assembly and DNA binding
similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane mutation is suppressed by expression human p53 protein
similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII
similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments
similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phoshporylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets
highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth
similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF
highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family
similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF
similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM
weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate
mitochondrial 54S ribosomal protein YmL15
similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis
highly similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase
highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p
some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication- linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I)
similar to uniprot|P32601 Saccharomyces cerevisiae YPR017C DSS4 Nucleotide release factor functioning in the post-Golgi secretory pathway required for ER-to-Golgi transport binds zinc found both on membranes and in the cytosol guanine nucleotide dissociation stimulator
highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton
some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF
similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C
similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF
highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector
some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating
highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization
similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Hypothetical ORF
similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis- Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD() salvage pathway gene pyrazinamidase and nicotinamidase
weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2
similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p
similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane
some similarities with uniprot|P27705 Saccharomyces cerevisiae YGL035C
similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes
highly similar to uniprot|P78609 Pichia jadinii Uricase
weakly similar to uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha-acetyl-transferase transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins
similar to uniprot|P32781 Saccharomyces cerevisiae YGL032C AGA2 Adhesion subunit of a-agglutinin of a-cells C-terminal sequence acts as a ligand for alpha- agglutinin (Sag1p) during agglutination modified with O- linked oligomannosyl chains linked to anchorage subunit Aga1p via two disulfide bonds
similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B
highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit
highly similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein
similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation
similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1
similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
similar to uniprot|P38892 Saccharomyces cerevisiae YHR209W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
highly similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall
similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes
similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase
similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase
similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p)
similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate
some similarities with uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 whiskey (whi) mutant forms a tetramer with VPS52 VPS53 and VPS54
weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W TAX4 and to uniprot|P36115 Saccharomyces cerevisiae YKR019C IRS4
similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF
similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF
similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes
weakly similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide- binding protein
similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromosome transmission
some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs
weakly similar to uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF
similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p
some similarities with uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure
similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells also required with Rec8p for cohesion and recombination during meiosis phylogenetically conserved SMC chromosomal ATPase family member
similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1
weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2
similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p
similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery
similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N-acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p
similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C and to uniprot|P38150 Saccharomyces cerevisiae YBR284W Hypothetical ORFs
similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial
weakly similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis; probable purine nucleotide-binding protein
weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation
similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1 homolog of the S. pombe and mammalian Chk1 checkpoint kinases Protein kinase Chk1
similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF
similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C
highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus
weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p
highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex
similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane.
similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Hypothetical ORF
weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains
similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
weakly similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase
similar to uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF
similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein
highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway potential Cdc28p substrate
similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC
mitochondrial 54S ribosomal protein YmL37
similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity
similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains
similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase
similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF
mitochondrial 54S ribosomal protein YmL8
similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF
similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle
some similarities with uniprot|P40366 Saccharomyces cerevisiae YJL065C DLS1 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p Isw2p and Dpb4p involved in inheritance of telomeric silencing
weakly similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches
similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes
similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF
similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF
similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF
similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data
mitochondrial 54S ribosomal protein YmL27
similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential
similar to uniprot|P38341 Saccharomyces cerevisiae YBR262C Hypothetical protein
similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization
weakly similar to uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition
some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition
similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P
similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF
similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
similar to uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing
similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and to YFR014C uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1 Calmodulin-dependent protein kinase
highly similar to uniprot|P23337 Saccharomyces cerevisiae or YLR258W uniprot|P27472 Saccharomyces cerevisiae
some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF
weakly similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF
similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF
similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1
similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF
similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 homolog of nuclear distribution factor NudE NUDEL
similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF
similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17 required for ethanol metabolismand induced by heat shock localized to the inner mitochondrial membrane
some similarities with uniprot|P36111 Saccharomyces cerevisiae YKR015C Hypothetical ORF
weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF
highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm
highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin-associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex
some similarities with uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF
some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations
highly similar to uniprot|P53978 Saccharomyces cerevisiae YNL014W HEF3 Translational elongation factor EF-3 paralog of YEF3 and member of the ABC superfamily stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome normally expressed in zinc deficient cells
similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W SPO1 Meiosis-specific protein with similarity to phospholipase B
similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF
highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF
highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha-ketoglutarate levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype
highly similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs) probable rRNA pseudouridine synthase binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p
some similarities with uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog
highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat
some similarities with uniprot|P48743 Saccharomyces cerevisiae YLR176C
similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C
highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway
highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria
similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth
similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion
similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
mitochondrial 54S ribosomal protein YmL2
similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria
some similarities with uniprot|P25587 Saccharomyces cerevisiae YCL005W Hypothetical ORF
similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate- limiting step of cardiolipin biosynthesis
similar to uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER
similar to uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA-binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division
highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM
mitochondrial 54S ribosomal protein YmL32
some similarities with uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
highly similar to uniprot|P00890 Saccharomyces cerevisiae YNR001C CIT1 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate the rate-limiting enzyme of the TCA cycle nuclear encoded mitochondrial protein
similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W SAT4 Ser/Thr protein kinase involved in salt tolerance
highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress
similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C MHT1 S-methylmethionine-homocysteine methyltransferase
highly similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase
similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF
similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis
similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5- bisphosphate-binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre- autophagosomal structure
weakly similar to uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase
similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase
similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae
similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84
weakly similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W YSC83
highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA
highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability
similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control
similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p
similar to uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase enabling it to act on key substrates to effect a decrease in CDK/B- cyclin activity and mitotic exit
DNA transposon of KLTH part of the newly discovered ROVER DNA transposon family of the Kluyveromyces:full length copy
similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs
weakly similar to uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C Hypothetical ORF
similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds
similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily expression is induced by low levels of glucose and repressed by high levels of glucose
similar to uniprot|P38967 Saccharomyces cerevisiae YOL020W TAT2 Tryptophan permease high affinity
highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family
highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA
similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability
similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2
similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane
some similarities with uniprot|P43598 Saccharomyces cerevisiae YFR017C Putative protein of unknown function
some similarities with uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 Protein involved in determination of longevity
highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis
similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 Probable homolog of mammalian DNA polymerase beta may function in double-stranded DNA break repair DNA polymerase IV
similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Hypothetical ORF
similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Hypothetical ORF
similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
weakly similar to uniprot|P40342 Saccharomyces cerevisiae YNR004W Hypothetical ORF
similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion
highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
highly similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1 6-bisphosphatase (FBPase) cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Subunit of the RSC chromatin remodeling complex
similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome
similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles
highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions
similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies
similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake member of the Ras superfamily of G-proteins
some similarities with uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism as suggested by computational analysis of large-scale protein- protein interaction data GFP-fusion protein localizes to the nuclear periphery
weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex
similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase
similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical ORF
highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins
highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase
similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W
similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity
weakly similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate
highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase
similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription- coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein
similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF
highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex
similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
some similarities with uniprot|P47107 Saccharomyces cerevisiae YJR039W Hypothetical ORF
highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post-Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates
similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis
similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H()-ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis
weakly similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error-prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p
similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C
similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl- thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology
similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6- pentakisphosphate 2-kinase nuclear protein required for synthesis of 1 2 3 4 5 6-hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable
highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric
similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane has a conserved methyltransferase motif multicopy suppressor of respiratory defects caused by OXA1 mutations
highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p).
similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya
weakly similar to uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity
weakly similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W Hypothetical ORF
similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Hypothetical ORF
highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3-epoxide a step in ergosterol biosynthesis
weakly similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein
highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs which are required for pseudouridylation and processing of pre-18S rRNA
highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore
similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability
highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism
highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD() synthetase essential for the formation of NAD() from nicotinic acid adenine dinucleotide
carboxylesterase-mitochondrial 37S ribosomal protein YmS2
similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein
some similarities with uniprot|P38704 Saccharomyces cerevisiae YHR006W STP2 Transcription factor activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids activates transcription of amino acid permease genes
similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p
similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase
similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth
similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end
similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p
similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF
highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2
similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter
weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein
highly similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA
similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)- resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation
highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YMR242c RPL20A and highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YOR312C RPL20B
some similarities with uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage
weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W Protein of unknown function found in the cytoplasm and the nucleus potential Cdc28p substrate
similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1
similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF
similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized stress-responsive protein that negatively regulates the H()-ATPase Pma1p induced by heat shock ethanol treatment weak organic acid glucose limitation and entry into stationary phase
similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF
weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase
highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082w RPL13A ribosomal protein or uniprot|P40212 Saccharomyces cerevisiae YMR142c RPL13B
highly similar to uniprot|P40213 Saccharomyces cerevisiae YMR143w RPS16A or uniprot|P40213 Saccharomyces cerevisiae YDL083c RPS16B
weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF
similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase
highly similar to uniprot|Q3E7B7 Saccharomyces cerevisiae YDL085C-A
highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation
similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W
similar to uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF
some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W Hypothetical ORF
similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit
similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial
highly similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site
similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W
weakly similar to uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p
weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate
weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C
similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C
weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Protein required for splicing of COB aI5 intron Cytochrome B pre-mRNA processing protein
some similarities with uniprot|Q07887 Saccharomyces cerevisiae YLL049W
highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 yeast cortical cytoskeleton component mammalian cofilin homolog Cofilin actin binding and severing protein
similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF
some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C
some similarities with uniprot|P52960 Saccharomyces cerevisiae YOR363C PIP2 peroxisome induction pathway 2 (PIP2) transcriptional activator of peroxisome proliferation may form heterodimer with Oaf1 to activate oleate-inducible gene expression activator of peroxisome proliferation
weakly similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6
similar to uniprot|Q08579 Saccharomyces cerevisiae YOR192C Hypothetical ORF
similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W Hypothetical ORF