Lachancea thermotolerans CBS 6340 chromosome D complete sequence.
Lachancea thermotolerans CBS 6340 (Kluyveromyces thermotolerans CBS 6340)
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
Comparative genomics of protoploid Saccharomycetaceae
Submitted (05-JUN-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (04-JUN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CU928168.\nThe Lachancea thermotolerans sequence is made of 8 chromosomes (A\nto H). The sequence was annotated by the Genolevures Consortium.\nFor more information go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C
similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
highly similar to uniprot|P40893 Saccharomyces cerevisiae YJL217W Hypothetical ORF
some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins
similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 Putative purine-cytosine permease
similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH
weakly similar to uniprot|P53344 Saccharomyces cerevisiae YGR295C COS6 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins
similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport
similar to uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase
similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor
similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores
highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesize glutamate from ammonia and alpha- ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
weakly similar to uniprot|P54862 Saccharomyces cerevisiae YOL156W HXT11 Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
similar to uniprot|P39713 Saccharomyces cerevisiae YAL061W putative polyol dehydrogenase
similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export
highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed
weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque required for exit from mitosis
weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division
weakly similar to uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p
similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
highly similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C
similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W
similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death
highly similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit
weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization
similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
highly similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C Hypothetical ORF
similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein
similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm
similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon
some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1
similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII
similar to uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated glucose-repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex
similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C
similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport
some similarities with uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing
similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF
similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source
weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin
DNA transposon of KLTH part of the newly discovered ROVER DNA transposon family of the Kluyveromyces:degenerate copy
weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids
similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS)
similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability
similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF
similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase functions in meiotic checkpoint phosphorylates Red1p interacts with Hop1p required for meiotic recombination and normal spore viability
weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C
weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl
similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease
highly similar to uniprot|P00549 Saccharomyces cerevisiae YAL038W CDC19 Pyruvate kinase functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA
some similarities with uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix- loop-helix/leucine-zipper protein family
weakly similar to uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF
highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins
similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2
highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I
similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43
similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly
highly similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C
similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF
similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator and to YLR098C uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; DNA-binding transcriptional activator or CHA1
similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects
highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog
similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p
some similarities with uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate
similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2) channel required for maintenance of intramitochondrial Mg(2) concentrations at the correct level to support splicing of group II introns
similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa)
similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase
some similarities with uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants
similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog
similar to uniprot|P19524 Saccharomyces cerevisiae YOR326W MYO2 One of two type V myosins involved in polarized distribution of mitochondria required for mitochondrion and vacuole inheritance and nuclear spindle orientation moves multiple cargo
similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W Hypothetical ORF
highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis
highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2)-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA
some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus
similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p-GTP
weakly similar to uniprot|P52960 Saccharomyces cerevisiae YOR363C PIP2 peroxisome induction pathway 2 (PIP2) transcriptional activator of peroxisome proliferation may form heterodimer with Oaf1 to activate oleate-inducible gene expression activator of peroxisome proliferation
similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C Hypothetical ORF
highly similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase
similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes
similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening
weakly similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1
some similarities with uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p
some similarities with uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Component of the Mediator complex interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme affects transcription by acting as target of activators and repressors
similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine induced by oxidative stress and heat shock
similar to uniprot|Q870H5 Saccharomyces cerevisiae YOL048C Hypothetical ORF
some similarities with uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF
similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF
similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail- anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol overexpression results in impaired peroxisome assembly
highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A
similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase
similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W
similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8
similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C
some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation
highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C
similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER
similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF
similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene
similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein interacts with Rhc18p and Nse1p to form a large complex S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
weakly similar to uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for formation of nuclear- associated array of smooth endoplasmic reticulum known as karmellae
similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance
similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation
similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A)
highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor contains five zinc fingers required for pre-mRNA 3'-end processing and polyadenylation
weakly similar to uniprot|Q06098 Saccharomyces cerevisiae YPR106W ISR1 Predicted protein kinase overexpression causes sensitivity to staurosporine which is a potent inhibitor of protein kinase C
highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p
similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex
similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C
highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit
similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p
similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3
similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W
similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF
similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37
highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a positive regulator of GCN4 expression
similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G- like protein
similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury
similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein
similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W
similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability
mitochondrial 54S ribosomal protein YmL49
some similarities with uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway which controls cell integrity upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward- rectifier potassium channel
weakly similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate
similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control
weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 Possibly involved in Snf1p regulated transcriptional activation shows homology to DNA binding domain of Gal4p has a leucine zipper motif and acidic region lexA-Sip4p activates transcription
weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability
similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy
highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis
similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins
similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W Hypothetical ORF
some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220
highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates bound by ubiquitin-protein ligases Ubr1p and Ufd4p localized mainly to the nucleus throughout the cell cycle
similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W
some similarities with YGR161c, uniprot|P53289 Saccharomyces cerevisiae Hypothetical ORF, RTS3 SGDID:S0003393
some similarities with uniprot|P08068 Saccharomyces cerevisiae YIR019C GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth
some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre- rRNA processing and ribosome biogenesis
similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8
similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH
similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl- ethanolamine N-methyltransferase
highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus
similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative)
highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis
similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry
similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS
similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p
weakly similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein
similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate-grown cells
similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport
some similarities with uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression
some similarities with uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF and to YKL141W uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone, member of GLR.231
similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes
similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
weakly similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering
mitochondrial 54S ribosomal protein YmL31
similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF
similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin-associated protein (AP-1) complex
highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G-beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1
similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources
highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control
similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline-rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3
similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C
similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C Hypothetical ORF
similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme
similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C Hypothetical ORF
similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis
similar to uniprot|Q04437 Saccharomyces cerevisiae YMR106C YKU80 Forms heterodimer with Yku70p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes
highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism
similar to uniprot|P12688 Saccharomyces cerevisiae or to YMR 104C, YKL126W YPK1 Serine/threonine protein kinase required for receptor-mediated endocytosis involved in sphingolipid-mediated and cell integrity signaling pathways localized to the bud neck cytosol and plasma membrane homolog of mammalian kinase SGK
some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor
similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W
similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex
similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis
highly similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family
weakly similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
weakly similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane
similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions
similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W
highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF
similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway
highly similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations
similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family
some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation gene silencing and DNA replication and repair
weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF
similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin
similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane essential for respiratory competence likely functions in assembly of the large ribosomal subunit has homologs in plants and animals
highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase-induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1
similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1
weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis
weakly similar to uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Protein required for DNA replication phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks) phosphorylation is essential for DNA replication and for complex formation with Dpb11p potential Cdc28p substrate
highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4
similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import
similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain
similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
weakly similar to uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase
weakly similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p
similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 Alcohol dehydrogenase isoenzyme III
similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
weakly similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF
some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization
similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles
highly similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons
similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types
highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism products of which are regulators in Golgi to plasma membrane transport functionally homologous to mammalian PITPs
similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint
some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor
similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination
similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p
similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21-activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus
mitochondrial 37S ribosomal protein MRP4
similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit
highly similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p and highly similar to YKL008C uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p
similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p- Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation as well as for recycling of Golgi proteins and formation of lumenal membranes
similar to uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches
highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment
highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit
weakly similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation contains a TFIIS-like domain and a PHD finger multicopy suppressor of temperature-sensitive ess1 mutations probably binds RNA polymerase II large subunit
similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance
mitochondrial 37S ribosomal protein YmS16
highly similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator
highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis
similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism
highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p
similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs
highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability
weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function
similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation
some similarities with uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1
similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling
similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex
similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3- hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain
some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex
similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification
highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family
similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized
similar to uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF
similar to uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening
weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake
similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family
similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation
some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF
some similarities with uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl- transferase involved in acetylation of the N-terminal residues of histones H4 and H2A
some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes
highly similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein
some similarities with uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b
weakly similar to uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF
some similarities with uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF
similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function
similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold
some similarities with uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF
similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm.
similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
similar to uniprot|P38748 Saccharomyces cerevisiae YHL010C Hypothetical ORF
highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes
similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase
highly similar to uniprot|P32861 Saccharomyces cerevisiae YKL035W UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase EC:2.7.7.9
some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor
similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF
similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1
similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20
similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway
similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein
similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C
similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF
similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins
some similarities with uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes
similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion
similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W
weakly similar to uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol-P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation
C/D snoRNA polycistronic Cluster 1 SNR78
C/D snoRNA polycistronic Cluster 1 SNR77
C/D snoRNA polycistronic Cluster 1 SNR76
C/D snoRNA polycistronic Cluster 1 SNR75
C/D snoRNA polycistronic Cluster 1 SNR74
C/D snoRNA polycistronic Cluster 1 SNR73
C/D snoRNA polycistronic Cluster 1 SNR72
similar to uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs
weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB) involved in SPB duplication may facilitate attachment of the SPB to the nuclear membrane
some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors
weakly similar to uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two-hybrid assay
highly similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair
similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis
similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly
highly similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p
similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF
similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C
mitochondrial 54S ribosomal protein YmL3
similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p
highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis
highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose-ethanol- and autoregulation involved in amino acid catabolism and to YLR134W uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition
similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA-binding zinc knuckle motif
highly similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain
similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
some similarities with uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p
highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF
similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl- carrier-protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p
some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII
highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology
weakly similar to uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases
similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W
similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain- containing protein required for cytokinesis
highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A
similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein
similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Hypothetical ORF
similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase
some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25
similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring
similar to uniprot|P33749 Saccharomyces cerevisiae YKL062W MSN4 Transcriptional activator related to Msn2p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression
similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C
similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W
some similarities with uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator
similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF
similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein
some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C
similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins
highly similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA
weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced
similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W
similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog
some similarities with uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p
some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway
similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
similar to uniprot|P53930 YNL107W Saccharomyces cerevisiae YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p
similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W
similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF
similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm
similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation
similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W
similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing
some similarities with uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III
similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase responsible for arginine degradation expression responds to both induction by arginine and nitrogen catabolite repression disruption enhances freeze tolerance
similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p
similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase
weakly similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 Transcription factor IIA large chain
weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis component of the FEAR regulatory network which promotes Cdc14p release from the nucleolus during anaphase potential Cdc28p substrate
similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization targets the essential Rho-GTPase Cdc42p which controls establishment and maintenance of cell polarity including bud-site assembly
highly similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C
similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC)
highly similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases
similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes implicated in secretion and nuclear segregation multicopy suppressor of BFA (Brefeldin A) sensitivity
similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) catalyzes an essential activation step in the isoprenoid biosynthetic pathway required for viability
similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical conserved nucleotide in mitochondrial 21S rRNA
highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphate dehydratase catalyzes the sixth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control via Gcn4p
similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the large subunit MRP51
similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala- Asp)-box RNA helicase required for translation initiation of all yeast mRNAs mutations in human DEAD-box DBY are a frequent cause of male infertility
similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C
highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III which is responsible for the transcription of tRNA and 5S RNA genes and other low molecular weight RNAs
similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination forms heterodimer with Sae3p proposed to be an assembly factor for Dmc1p
similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre- ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes both complexes mediate intranuclear transport of ribosomal precursors
similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Protein required for sorting and delivery of soluble hydrolases to the vacuole
highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases
similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen- activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus
similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits
highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase
similar to uniprot|Q02931 YPL126W Saccharomyces cerevisiae NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3
highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III
similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p
similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1, a linker histone required for nucleosome packaging at sites
some similarities with uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor
similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit
weakly similar to uniprot|Q99314 Saccharomyces cerevisiae YOR213C SAS5 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain
similar to uniprot|Q12032 YOR215C Saccharomyces cerevisiae Hypothetical ORF
similar to uniprot|Q12234 YOR216C Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi
similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a- factor
highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit
weakly similar to uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF
similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase
similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator
weakly similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
similar to uniprot|Q99297 Saccharomyces cerevisiae YOR222W ODC2 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF
highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
highly similar to uniprot|Q12056 Saccharomyces cerevisiae YOR226C ISU2 Conserved protein of the mitochondrial matrix required for synthesis of mitochondrial and cytosolic iron-sulfur proteins
similar to uniprot|Q12276 Saccharomyces cerevisiae YOR227W Hypothetical ORF
weakly similar to uniprot|Q12106 Saccharomyces cerevisiae YOR228C Hypothetical ORF
similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C
weakly similar to uniprot|Q12206 YOR229W Saccharomyces cerevisiae WTM2 WD repeat containing transcriptional modulator 2
some similarities with uniprot|P32490 Saccharomyces cerevisiae YOR231W MKK1 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk2p
similar to uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria
similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C Hypothetical ORF
highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W, RPL33A Ribosomal Protein of the Large subunit
similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function
similar to uniprot|P35844 Saccharomyces cerevisiae YPL145C KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions peripheral membrane protein that localizes to the Golgi complex
similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired
similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Hypothetical ORF
similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter
similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation
similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W
similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria
some similarities with uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation
similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35
similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome
highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression
similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Resistant to Rapamycin
similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles
weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p
highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates
similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning
some similarities with uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein predicted to have 1 transmembrane segment transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase
weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF
similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF and weakly similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YBR177c uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase, may be involved in lipid metabolism, null mutant slightly temperature sensitive at 37C
similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome
highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA
similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases
similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p
similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C
similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability
weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition
similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit
similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate
similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6
some similarities with uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage
highly similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF
some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W
similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing
similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP
weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers
highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis
similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C
similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis mutations cause defects in transcription and in biogenesis of cell wall proteins
weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued)
highly similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p
mitochondrial 54S ribosomal protein YmL40
similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle
similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression
similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders
highly similar to uniprot|Q6Q5I7 Saccharomyces cerevisiae YOR261C
highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability
weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate
similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta- tubulin
weakly similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein
similar to uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H()-ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis
similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1
similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate
highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF
highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein
similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF
similar to uniprot|Q12256 Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein
similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W
similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms
similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation
similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N- terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p
similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap- binding complex involved in translational control repressor of cap-dependent translation initiation competes with eIF4G for binding to eIF4E
similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog
similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C
highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway
similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic
similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate
weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p
similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C or uniprot|Q99369 Saccharomyces cerevisiae YOR280C FSH3 Serine hydrolase
similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5- Acetyltransferase) acetylation complex required for SAGA- mediated deubiquitination of histone H2B
similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C
similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved
similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W
similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W
similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF
weakly similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability
mitochondrial 54S ribosomal protein YmL44
similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family overexpression suppresses the defect in maturation of carboxypeptidase Y and defects in other essential Pdi1p functions caused by PDI1 deletion
similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF
highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP()-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids
similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator
some similarities with uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation
similar to uniprot|P14908 Saccharomyces cerevisiae YMR228W MTF1 Mitochondrial RNA polymerase sigma- like specificity factor required for promoter recognition interacts with mitochondrial core polymerase Rpo41p imported into mitochondria via a novel process requiring most of the Mtf1p sequence
similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs
similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W Hypothetical ORF
similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Hypothetical ORF
highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit
some similarities with uniprot|P53238 Saccharomyces cerevisiae YGR058W Hypothetical ORF
similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway
highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol
highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Hypothetical ORF
similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C
highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation and plays a role in pre-mRNA processing in addition Spt4p is involved in kinetochore function and gene silencing
similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W Hypothetical ORF
similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter
highly similar to uniprot|Q3E7Y3 Saccharomyces cerevisiae YLR367w RPS22B or uniprot|P0C0W1 Saccharomyces cerevisiae YJL190c RPS22A
similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C Hypothetical ORF
weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 Protein involved in determination of mitochondrial structure
highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins
highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP
similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26- carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis
similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids
weakly similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects
similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein
weakly similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C PSY3 Protein of unknown function deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Hypothetical ORF
similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase
highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism
some similarities with uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein
similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C
highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER
similar to uniprot|P38196 SYBL042C Saccharomyces cerevisiae YBL042C FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport
highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure
similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF
similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance
weakly similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules
similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance
similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination
similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene
similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA homologous to Rad52p
similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin
similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7
similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p
similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Protein of unknown function, similar to Rei1p but not involved in bud growth
similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm associates with pre-40S ribosomal particles
highly similar to uniprot|P41057 Saccharomyces cerevisiae YLR388W RPS29A and to uniprot|P41058 Saccharomyces cerevisiae YDL061C RPS29B Proteins component of the small (40S) ribosomal subunit
similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family
some similarities with uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Non-essential protein of unknown function
similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C
highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins
some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response proteins
weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C Hypothetical ORF
similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6
highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
highly similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF
similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting
similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs
similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase
similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p
similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein
similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region
some similarities with uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies
similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W Hypothetical ORF
similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Hypothetical ORF
similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain
similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p
highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit
similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Hypothetical ORF
weakly similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C Hypothetical ORF
similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis
highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase
similar to uniprot|Q06686 Saccharomyces cerevisiae YLR411W CTR3 High-affinity copper transporter of the plasma membrane acts as a trimer gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes
similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W Hypothetical ORF
highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities
similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature
similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase
weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate
similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA
some similarities with uniprot|P34231 Saccharomyces cerevisiae YKL187C and some similarites with uniprot|Q06689 Saccharomyces cerevisiae YLR413W
similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud
similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2
similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome
similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response
similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF
similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones
highly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression
highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase regulatory B subunit of calcineurin
similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p
highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase
similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid
similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF
similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p
similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase
similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase
similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA
some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins
highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport
similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate
similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF
similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25
similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA
similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity
similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate
weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 and to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 and to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein
similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing
weakly similar to uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function
weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C Hypothetical ORF
highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive
similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine
highly similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay
mitochondrial 54S ribosomal protein YmL4
similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA
similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA
similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion
some similarities with uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex which is a nuclear complex comprised of Hpr1p Mft1p Rlr1p and Thp2p that is involved in transcription elongation and mitotic recombination
highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit
similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily
similar to uniprot|P54784 Saccharomyces cerevisiae YML065W ORC1 Largest subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p
similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential protein of unknown function
some similarities with uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly
similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles
weakly similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF
similar to uniprot|Q04638 Saccharomyces cerevisiae YML068W ITT1 Protein that modulates the efficiency of translation termination interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro contains a zinc finger domain characteristic of the TRIAD class of proteins
highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation
highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation
similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Hypothetical ORF
similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter
highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d
some similarities with uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact
highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W
highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae
similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae
similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor
similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p
highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria
similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation
some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation
highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase
similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis
similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria
similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5
similar to uniprot|P38889 Saccharomyces cerevisiae YHR206W
similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts
similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B
similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Hypothetical ORF
similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance component of the mitochondrial nucleoid required for the repair of oxidative mtDNA damage
similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase
similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Hypothetical ORF
similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix
similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Protein required for cell viability
similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor
highly similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase
similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1
highly similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome
highly similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C ECM17 Sulfite reductase beta subunit involved in amino acid biosynthesis transcription repressed by methionine
some similarities with uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non- tagged protein was localized to the mitochondria
weakly similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C Hypothetical ORF
highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein
weakly similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance component of the kinetochore binds to centromeric DNA in a Ctf19p-dependent manner
similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein
weakly similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild-type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus
highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase
similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog
highly similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology
similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes
similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Hypothetical ORF
similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane
similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine
similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase
similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W Hypothetical ORF
similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17
similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin)
similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70