Lachancea thermotolerans CBS 6340 chromosome C complete sequence.
Lachancea thermotolerans CBS 6340 (Kluyveromyces thermotolerans CBS 6340)
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
Comparative genomics of protoploid Saccharomycetaceae
Submitted (05-JUN-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (04-JUN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CU928167.\nThe Lachancea thermotolerans sequence is made of 8 chromosomes (A\nto H). The sequence was annotated by the Genolevures Consortium.\nFor more information go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
DNA transposon of KLTH part of the newly discovered ROVER DNA transposon family of the Kluyveromyces:degenerate copy
similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Hypothetical ORF
some similarities with uniprot|P53053 Saccharomyces cerevisiae YGL263W COS12 Protein of unknown function member of a family of conserved often subtelomerically- encoded proteins
similar to uniprot|Q2TZW5 Aspergillus oryzae AO090011000693 Protein involved in biosynthesis of mitomycin antibiotics/polyketidefumonisin
similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF
similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF, memberof the Dal5p subfamily of the major facilitator family
similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor
similar to uniprot|P00635 Saccharomyces cerevisiae YBR093C PHO5 One of three repressible acid phosphatases a glycoprotein that is transported to the cell surface by the secretory pathway induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH
some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation
highly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily expression is induced by low levels of glucose and repressed by high levels of glucose
similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p- Pan3p poly(A)-ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C or to uniprot|P40580 Saccharomyces cerevisiae YIR036C Hypothetical ORFs
highly similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6
similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation
highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L-lysine-forming) catalyzes the conversion of saccharopine to L-lysine which is the final step in the lysine biosynthesis pathway
similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta- transducin repeats
similar to uniprot|P40578 Saccharomyces cerevisiae YIR033W MGA2 or to uniprot|P35210 Saccharomyces cerevisiae YKL020C SPT23, ER membrane proteins involved in regulation of OLE1 transcription
similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit
similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase
some similarities with uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC) needed for meiotic nuclear division
similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A
highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha- associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities
highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis
similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type
similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit
similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control
similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex
highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Hypothetical ORF
similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease
some similarities with uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability
weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381w FRE3 protein Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters
highly similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process
similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1
similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response activates the pathway via Scp160p
similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes
weakly similar to uniprot|Q08909 Saccharomyces cerevisiae YOR385W Hypothetical ORF
highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle
similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex
similar to uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth
weakly similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
weakly similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration
similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability
elongation factor 1 gamma domain-containing protein
similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF- 1gamma
highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector
some similarities with uniprot|Q06150 Saccharomyces cerevisiae YLR267W BOP2 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation
weakly similar to uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins
some similarities with uniprot|P38854 Saccharomyces cerevisiae YHR159W Protein of unknown function that localizes to the cytoplasm potential Cdc28p substrate
similar to uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate
some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF
similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF
some similarities with uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing
similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin- CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p
similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6
highly similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p
some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W
similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein
similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1
weakly similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF
similar to uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p
similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation
similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5- bisphosphate-binding protein predicted to fold as a seven- bladed beta-propeller displays punctate cytoplasmic localization
similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane
weakly similar to uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate
highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
mitochondrial 54S ribosomal protein YmL16
similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit
mitochondrial 54S ribosomal protein YmL9
similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit
highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus
similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones
similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol
mitochondrial 37S ribosomal protein RSM27
similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit
highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit
similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF
weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W Hypothetical ORF
weakly similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin
highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p)
weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA involved in RNA splicing
similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W Hypothetical ORF
highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre-ribosomal particles
similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C Hypothetical ORF
highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C-terminal domain of Hyp2p (eIF5A) has four to five HEAT-like repeats
similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N-hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis
similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA
weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein binds eIF4E and inhibits cap-dependent translation also functions independently of eIF4E to maintain genetic stability plays a role in cell growth implicated in the TOR signaling cascade
highly similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function
highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg
highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity
highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo
highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex
similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p) involved in mannosylphosphorylation of N-linked oligosaccharides expression increases in late-logarithmic and stationary growth phases
some similarities with uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Helix-loop-helix protein that binds the motif CACRTG (R
weakly similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake
similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP-binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes
highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p
some similarities with uniprot|P50263 Saccharomyces cerevisiae YMR175W
some similarities with uniprot|P47115 Saccharomyces cerevisiae YJR056C Hypothetical ORF
similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Multicopy suppressor of rvs167 mutation putative integral membrane protein
similar to uniprot|P04387 Saccharomyces cerevisiae YML051W GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose inhibits transcriptional activation by Gal4p inhibition relieved by Gal3p or Gal1p binding
similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature
similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W Hypothetical ORF
similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing
similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression
some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate
similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats
similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4)
similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF
similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C Fumurate ReDuctase Soluble
highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis
similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
highly similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Hypothetical ORF
weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W Hypothetical ORF
similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest
similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2
similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p)
similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance
highly similar to uniprot|P00044 Saccharomyces cerevisiae CYC1 Cytochrome c isoform 1 and to YEL039C uniprot|P00045 Saccharomyces cerevisiae CYC7 Cytochrome c isoform 2
similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus
similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23
similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex
highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A
similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase
similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication)
similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes
similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C
mitochondrial 54S ribosomal protein YmL33
similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase
weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
weakly similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp
similar to uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator
similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data
similar to uniprot|P13090 Saccharomyces cerevisiae YML116W ATR1 Multidrug efflux pump of the major facilitator superfamily required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N-glycosylation
highly similar to uniprot|Q08985 Saccharomyces cerevisiae YPL273W SAM4 S-adenosylmethionine-homocysteine methyltransferase functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF
similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase
weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation
some similarities with uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome
weakly similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts
similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
similar to uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3- ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1
similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease
similar to uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p
similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha-beta sandwiches.
highly similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme
weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery
highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1
similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19
similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit
weakly similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds
some similarities with uniprot|Q03525 Saccharomyces cerevisiae YMR269W Nucleolar protein of unknown function
similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC)
similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein.
weakly similar to uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF
similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans
similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination
weakly similar to uniprot|P53133 Saccharomyces cerevisiae YGL117W Hypothetical ORF
similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci
similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF
similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex and to YML100W uniprot|P38427 Saccharomyces cerevisiae YML100W TSL1 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product
highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A
similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Hypothetical ORF
similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C Hypothetical ORF
weakly similar to uniprot|P08468 Saccharomyces cerevisiae YMR257C PET111 Specific translational activator for the COX2 mRNA located in the mitochondrial inner membrane
some similarities with uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p-binding protein
highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
weakly similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W Hypothetical ORF
some similarities with uniprot|Q04839 Saccharomyces cerevisiae YMR255W GFD1 Coiled-coiled protein of unknown function identified as a high-copy suppressor of a dbp5 mutation
similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF
weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase
highly similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation
some similarities with uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization, possible component of the TOR nutrient signaling pathway
weakly similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex required for Cdc7p kinase activity and initiation of DNA replication phosphorylates the Mcm2-7 family of proteins cell cycle regulated
some similarities with uniprot|P53753 Saccharomyces cerevisiae YNR067C
similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF
highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents
similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF
similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference
similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases
highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase
similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF
similar to uniprot|P38084 Saccharomyces cerevisiae YBR068C BAP2 High-affinity leucine permease functions as a branched-chain amino acid permease involved in the uptake of leucine isoleucine and valine contains 12 predicted transmembrane domains and to YDR046C uniprot|P41815 Saccharomyces cerevisiae YDR046C BAP3 Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis
highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
mitochondrial 37S ribosomal protein RSM10
similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF
similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p
similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex
similar to uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex
weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria
highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Tryptophan 2 3-dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF
similar to uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YPR032W uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae
similar to uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein Kinase C
similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF
similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex
some similarities with uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop- helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein Rtg1p to activate the retrograde (RTG) and TOR pathways
similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W
weakly similar to uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements
similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin-associated protein (AP) complex
similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion
similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization
highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis
similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy- terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover
similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics
similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p
similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF
similar to uniprot|P38682 Saccharomyces cerevisiae YER122C
similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component
highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein
similar to uniprot|P40075 Saccharomyces cerevisiae YER120W SCS2 Protein likely to be involved in regulating INO1 expression suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline involved in inositol metabolism regulator of INO1 expression
highly similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p
weakly similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high- osmolarity glycerol response pathway
similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene
highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W RPL23B and highly similar to uniprot|P04451 Saccharomyces cerevisiae YBL087C RPL23A Proteins component of the large (60S) ribosomal subunit
some similarities with uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair
similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
similar to uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud-emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
some similarities with uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition
similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF
weakly similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay
some similarities with uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor
highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1
similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1- 3) mannosyltransferase involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
weakly similar to uniprot|P40068 Saccharomyces cerevisiae YER109C FLO8 Transcription
highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p
some similarities with uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF
similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation
similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation
highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy
weakly similar to uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 Protein with a role in regulation of Ty1 transposition
highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A
highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family
similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit
highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p
weakly similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein
similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway
highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes
some similarities with uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Suppressor of Essential Function putative transcription factor
similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress
similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation
similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein forms a helical filament with DNA that searches for homology involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis homolog of Dmc1p and bacterial RecA protein
weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF
highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10
highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca
similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF
similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability
similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase
similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase
similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I
similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation
similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF
some similarities with uniprot|Q03125 Saccharomyces cerevisiae YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
highly similar to uniprot|P11353 YDR044W Saccharomyces cerevisiae HEM13 Coproporphyrinogen III oxidase
highly similar to uniprot|Q04307 Saccharomyces cerevisiae YDR045C RPC11 RNA polymerase III subunit C11
some similarities with uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex
similar to uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Ser-Thr protein kinase
weakly similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases
weakly similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains
weakly similar to uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation
weakly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase
weakly similar to uniprot|P38081 YBR056w Saccharomyces cerevisiae Hypothetical ORF
similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex
similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co- inducer
similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF
similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C
similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
highly similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W Hypothetical
weakly similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSA protein
similar to uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing
similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex
some similarities with uniprot|Q12457 Saccharomyces cerevisiae YDR026C Hypothetical ORF
highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025w RPS18A or uniprot|P26781 Saccharomyces cerevisiae YBR048w RPS18B ribosomal protein
similar to uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23
similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C ZTA1 Zeta-crystallin homolog
similar to uniprot|P32833 Saccharomyces cerevisiae YBR060C ORC2 Subunit of the origin recognition complex
highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase
weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Protein involved in microtubule assembly
highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C Hypothetical ORF
similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone
similar to uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1)
similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS- MDR)
similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C Hypothetical ORF
similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating
similar to uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis
similar to uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats
similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore
some similarities with uniprot|Q03937 Saccharomyces cerevisiae YDR014W-A HED1 Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired
highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism
some similarities with uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity
highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery
mitochondrial 54S ribosomal protein YmL25
similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit
similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome
highly similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein
weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons
similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein-protein binding
highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation
mitochondrial 37S ribosomal protein YmS-T
similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin
similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate
similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p- Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering
similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly
similar to uniprot|P06700 Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan plays roles in silencing at HML HMR telomeres and the rDNA locus negatively regulates initiation of DNA replication
similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus
similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing
similar to uniprot|Q12362 Saccharomyces cerevisiae YOL066C Hypothetical ORF
similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5- bisphosphate 5-phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
weakly similar to uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G-protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'- phosphoadenosine-5'-phosphosulfate intermediates of the sulfate assimilation pathway
similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln
highly similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family
similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly
similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP-diaclglyerol a critical step in the synthesis of all major yeast phospholipids
similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF
weakly similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment
similar to uniprot|Q4WG56 Aspergillus fumigatus Afu7g03850 Oxidoreductase 2-nitropropane dioxygenase family putative
similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis
similar to uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
similar to uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis forms a complex with Ino2p that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF
mitochondrial 54S ribosomal protein YmL10/YmL18
similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC4
similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p
similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre-rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends
similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus
similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
some similarities with uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p
highly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
pumilio-family RNA binding domain-containing protein
similar to uniprot|Q04373 YDR496C Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences
similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein
weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation
similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase
similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae FMP36
similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc
similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis
similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF
similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery
weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8
highly similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration
highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA
similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative)
similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C
weakly similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting
similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription
similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W
highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W
similar to uniprot|Q12010 YOL092W Saccharomyces cerevisiae Hypothetical ORF
highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process contains a Walker ATP-binding motif required for repair activity Msh2p-Msh6p binds to and hydrolyzes ATP
similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified
weakly similar to uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression
similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus
weakly similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family exhibits chaperone activity overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions undergoes oxidation by Ero1p
weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrr1p acting on an overlapping set of target genes
similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation
similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates
similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF
similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1
similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF
highly similar to uniprot|P0C0X0 Saccharomyces cerevisiae YLR264W RPS28B or highly similar to uniprot|Q3E7X9 Saccharomyces cerevisiae YOR167C RPS28A
weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein involved in chromosome segregation during the first meiotic division
highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions
highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A TMA7
highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6
similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long- chain base phosphates which function as signaling molecules and similar to YOR171c
highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL
similar to uniprot|P23172 Saccharomyces cerevisiae YOR380W RDR1 Transcriptional repressor involved in the control of multidrug resistance negatively regulates expression of the PDR5 gene member of the Gal4p family of zinc cluster proteins
similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W Hypothetical ORF
similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor
similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger
highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin
similar to uniprot|P39105 Saccharomyces cerevisiae YMR008C PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate
highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity
similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae
similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF
weakly similar to uniprot|Q03673 Saccharomyces cerevisiae YMR003W Hypothetical ORF
similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF
some similarities with uniprot|Q08054 Saccharomyces cerevisiae YOL007C Appears to be a structural component of the chitin synthase 3 complex
similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I
highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C
highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C
similar to uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation
similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC-CRD protein
similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc
similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance
highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family
similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease
similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans
similar to uniprot|Q04263 Saccharomyces cerevisiae YML002W Hypothetical ORF
similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF
similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end-joining (NHEJ) forms stable heterodimer with required cofactor Lif1p catalyzes DNA ligation as part of a complex with Lif1p and Nej1p involved in meiosis not essential for vegetative growth
similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences
similar to uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability
similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation
similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase may play a role in steroid detoxification forms volatile esters during fermentation which is important in brewing
highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation
similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A SOM1 Protein whose overexpression suppresses the imp1 mutation may be required for the function of the Imp1p mitochondrial inner membrane peptidase and/or the protein sorting machinery
similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine- phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin
similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function
similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W
similar to uniprot|Q08984 Saccharomyces cerevisiae YPL272C Hypothetical ORF
similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C
similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane
weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
some similarities with uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide- specific phospholipase C hydrolyzes phosphatidylinositol 4 5-biphosphate (PIP2) to generate inositol 1 4 5- triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation
weakly similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1
highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA part of 90S and 40S pre-particles in nucleolus involved in pre-ribosomal RNA processing
similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions
weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF
some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W
highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF