Lachancea thermotolerans CBS 6340 chromosome A complete sequence.
Lachancea thermotolerans CBS 6340 (Kluyveromyces thermotolerans CBS 6340)
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
Comparative genomics of protoploid Saccharomycetaceae
Submitted (05-JUN-2017) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA
Submitted (04-JUN-2009) Genoscope - Centre National de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail : seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
PROVISIONAL REFSEQ: This record has not yet been subject to final\nNCBI review. The reference sequence is identical to CU928165.\nThe Lachancea thermotolerans sequence is made of 8 chromosomes (A\nto H). The sequence was annotated by the Genolevures Consortium.\nFor more information go to\nhttp://cbi.labri.fr/Genolevures.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: INSDC submitter\nAnnotation Status :: Full annotation\nAnnotation Pipeline :: Eukaryotic Annotation Propagation Pipeline\n##Genome-Annotation-Data-END##
weakly similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate
similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W Hypothetical ORF
similar to uniprot|P00331 Saccharomyces cerevisiae YMR303C ADH2 Glucose-repressible alcohol dehydrogenase II involved in the production of certain carboxylate esters
weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake
some similarities with uniprot|Q04179 Saccharomyces cerevisiae YDR400W URH1 uridine nucleosidase (uridine ribohydrolase)
similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF
similar to uniprot|P14065 Saccharomyces cerevisiae YOR120W GCY1 Putative NADP() coupled glycerol dehydrogenase proposed to be involved in an alternative pathway for glycerol catabolism
some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase reduces siderophore-bound iron prior to uptake by transporters expression induced by low iron levels
similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2
similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82
similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain
highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers
some similarities with uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy
highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1 6-amyloglucosidase activities required for glycogen degradation
highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation
similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein
similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI
highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein
similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability
similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C
similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex
highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate
weakly similar to uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition
highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA-type ATPase
similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Hypothetical ORF
similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease
similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton
highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B
highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Bp and has similarity to rat S19 ribosomal protein
highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A and highly similar to uniprot|P07279 Saccharomyces cerevisiae YNL301C RPL18B Protein component of the large (60S) ribosomal subunit
similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport
weakly similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
some similarities with uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit
some similarities with uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus
similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation
some similarities with uniprot|Q12322 Saccharomyces cerevisiae YOL114C Hypothetical ORF
similar to uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42
similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins
weakly similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W Hypothetical ORF
similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH
similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W
similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C Hypothetical ORF
similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane
similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase
similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein
highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
similar to uniprot|P39980 Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates transcription is induced during iron deprivation and diauxic shift potentially phosphorylated by Cdc28p
similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth
similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p
highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo
similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p may be involved in U2 snRNA folding contains two RNA recognition motifs (RRMs)
highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF
similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C
similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis
similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan
similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP-ribose 1''-phosphate a tRNA splicing metabolite may have a role in regulation of tRNA splicing
similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter
similar to uniprot|P04385 Saccharomyces cerevisiae YBR020W GAL1 Galactokinase phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism expression regulated by Gal4p and similar to YDR009W uniprot|P13045 Saccharomyces cerevisiae YDR009W GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose forms a complex with Gal80p and Gal4p to relieve inhibition by Gal80p binds galactose and ATP but does not have galactokinase activity
similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF
similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle
highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates
similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen
similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p
similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro
similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double-strand break repair
highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression
similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm
similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP-dependent RNA helicase
weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation
highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p
similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex
similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein
similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90
similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W
some similarities with uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF
mitochondrial 37S ribosomal protein MRPS16
similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit
similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift
similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation
highly similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER
similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF
similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD()-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD()-dependent histone deacetylase activity in vitro
similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase
similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative)
highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage
similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure
similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1)
similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex
similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras-Pka pathways
similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones
similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF
weakly similar to uniprot|Q12110 Saccharomyces cerevisiae YLR049C Hypothetical ORF
similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA
highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2
highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability
weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex
highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C
some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall
similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Protein involved in bud-site selection nutrient signaling and gene expression controlled by the TOR kinase diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb
similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
similar to uniprot|P06842 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane-spanning regions also involved in cysteine uptake
similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook
highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway
similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
some similarities with uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters
similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF
similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA)
highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p
similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism
weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrr1p acting on an overlapping set of target genes
similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches
highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2
weakly similar to to YER044C-A uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Functions in early recombination; mRNA is meiosis-specific and has 88 bp intron at 5' end spliced independently of MER1[INTRON]
some similarities with uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non-optimal carbon sources
similar to uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis
some similarities with uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system
similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF
similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family
similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A
similar to uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF
similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF
mitochondrial 37S ribosomal protein RSM18
weakly similar to uniprot|P40033 Saccharomyces cerevisiae YER050C
similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF
similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase
highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis
weakly similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways
similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s)
similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Mir1p but less abundant than Mir1p under normal conditions expression is induced at high temperature
weakly similar to uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p
similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus
highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control
similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein
highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases
highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
highly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase
similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated
similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease mediates purine (adenine guanine and hypoxanthine) and cytosine accumulation and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 Putative purine-cytosine permease
similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth
similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase
similar to uniprot|P40106 Saccharomyces cerevisiae HOR2 and to YIL053W uniprot|P41277 Saccharomyces cerevisiae RHR2, two redundant DL-glycerol-3-phosphatases
highly similar to uniprot|P40106 Saccharomyces cerevisiae HOR2 and to YIL053W uniprot|P41277 Saccharomyces cerevisiae RHR2, two redundant DL-glycerol-3- phosphatases
some similarities with uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); (putative) involved in transcription
some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF
similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription
highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF
similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C-terminal region of Not1p
weakly similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog
highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p
highly similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches
some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p
similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division
highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF
similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
weakly similar to uniprot|P40045 Saccharomyces cerevisiae YER071C Protein of unknown
highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance
highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme
highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B and highly similar to uniprot|P26782 Saccharomyces cerevisiae YER074W RPS24A proteins component of the small (40S) ribosomal subunit
highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Hypothetical ORF
some similarities with uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm
similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R
similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF
similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF
similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation
some similarities with uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF
similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria
highly similar to uniprot|P40510 and to YER081W uniprot|P40054 Saccharomyces cerevisiae SER3 3-phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p
highly similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p
highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C
weakly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid
similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function
similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p
similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF
highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic
similar to uniprot|P40507 Saccharomyces cerevisiae YIL079C AIR1 and similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C AIR2
similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane
similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF
highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix
similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C
highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth
similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W
weakly similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF
weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF
highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Hypothetical ORF
similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p
similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis
weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion
similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p
similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START; G(sub)1 cyclin
similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations
similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function
similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein
similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p-phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy
similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase
weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W Hypothetical ORF
similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
some similarities with uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity
highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore
weakly similar to uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF
highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6-bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes
highly similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress
similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing
similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase
similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth
similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase
highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids or YMR207C uniprot|P32874 Saccharomyces cerevisiae YMR207C HFA1 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system
similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C Hypothetical ORF
similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF
mitochondrial 54S ribosomal protein IMG1
similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome
highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF
similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF
similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF
similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation
some similarities with uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex
highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase
highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein
similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN)
similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
similar to uniprot|Q07923 Saccharomyces cerevisiae YLR011W LOT6 Putative NADPH-dependent FMN reductase with strong ferricyanide reductase activity in vitro gene expression increases in cultures shifted to a lower temperature
highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly
similar to uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif
similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p
similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway
similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF
similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation
mitochondrial 54S ribosomal protein IMG2
similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit
highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability
similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p
highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases
similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1
similar to uniprot|Q6B1Q1 Saccharomyces cerevisiae YNR033W
similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W
similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C
similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii
similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p
similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin
putative mitochondrial 37S ribosomal protein MRPS12
similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C
similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF
mitochondrial 37S ribosomal protein RSM19
highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C
similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family
similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit
similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc
similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
weakly similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF
some similarities with uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 mitochondrial thioredoxin
weakly similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 component of the yeast ADA acetyltransferase complex
similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer
weakly similar to uniprot|P35995 Saccharomyces cerevisiae YKL222c
some similarities with uniprot|P18323 Saccharomyces cerevisiae YCR084C
similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication
similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF
similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
some similarities with uniprot|P25653 Saccharomyces cerevisiae YCR089W FIG2 Cell wall adhesin expressed specifically during mating may be involved in maintenance of cell wall integrity during mating
similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF
weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane
highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability
similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate
similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability
some similarities with uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels
similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity
highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD) component of the cellular stress response
weakly similar to uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation
highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming)
similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
similar to uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor
weakly similar to uniprot|P39008 Saccharomyces cerevisiae YNR052C POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
some similarities with uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
similar to uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing
similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor
similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C Hypothetical ORF
highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF
weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C
similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF
highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance