Saccharomyces cerevisiae S288C chromosome XV, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome XV, complete sequence.
sequence version: NC_001147.6
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001147.6
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169874
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
reference: 9
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006948.\n\nOn Apr 26, 2011 this sequence version replaced NC_001147.5.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##

sequence
subclass of: SO_0000340
sequence length: 1091291
topology: linear
so has quality: SO_0000987
location: 1..1091291
location: region:1-1091291:1
RO_0002162: 559292

NC_001147
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
author: Dujon, B.
author: Albermann, K.
author: Aldea, M.
author: Alexandraki, D.
author: Ansorge, W.
author: Arino, J.
author: Benes, V.
author: Bohn, C.
author: Bolotin-Fukuhara, M.
author: Bordonne, R.
author: Boyer, J.
author: Camasses, A.
author: Casamayor, A.
author: Casas, C.
author: Cheret, G.
author: Cziepluch, C.
author: Daignan-Fornier, B.
author: Dang, D.V.
author: de Haan, M.
author: Delius, H.
author: Durand, P.
author: Fairhead, C.
author: Feldmann, H.
author: Gaillon, L.
author: Kleine, K. et al.
journal: Nature 387 (6632 SUPPL), 98-102 (1997)
pubmed: 9169874

9169874
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

7
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

8
title: Direct Submission
journal: Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

9
title: Direct Submission
journal: Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1091291:1
position: 1091291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-1091291:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: XV

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL15L; Telomeric region on the left arm of Chromosome XV; composed of an X element core sequence, X element combinatorial repeats, and a terminal stretch of telomeric repeats
so part of: sequence
location: complement(1..847)
location: region:1-847:-1
so has part: feature:1-847:-1:region

S000028929
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:847:-1
position: 847
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-847:-1:region

YOL166W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL166W-A
so part of: sequence
location: <585..>740
location: region:585-740:1
so has part: feature:585-740:1:exon
subclass of: SO_0000010

1466472
type: Gene
SIO_000068: ncbigene

position:585:1
position: 585
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:740:1
position: 740
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:585-740:1:exon

YOL166W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL166W-A
product: uncharacterized protein
transcript id: NM_001184623.1
SIO_010081: YOL166W-A
subclass of: SO_0000673
so part of: YOL166W-A
location: <585..>740
location: region:585-740:1
so has part: feature:585-740:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:585-740:1:exon

YOL166W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL166W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MHGACLSGLYPLPFTHKFHDYLHFNIYISFGGPKYCITALNTYVILFYTVY
SIO_010081: YOL166W-A
subclass of: SO_0000673
so part of: YOL166W-A
location: 585..740
location: region:585-740:1
so has part: feature:585-740:1:exon

NP_878160.1
type: Protein
SIO_000068: ncbiprotein

S000028709
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:585-740:1:exon

YOL165C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAD15
locus tag: YOL165C
so part of: sequence
location: complement(<1647..>2078)
location: region:1647-2078:-1
so has part: feature:1647-2078:-1:exon
subclass of: SO_0000010

853999
type: Gene
SIO_000068: ncbigene

position:1647:-1
position: 1647
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:2078:-1
position: 2078
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1647-2078:-1:exon

YOL165C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAD15
locus tag: YOL165C
product: putative aryl-alcohol dehydrogenase
transcript id: NM_001183418.1
SIO_010081: YOL165C
subclass of: SO_0000673
so part of: YOL165C
location: complement(<1647..>2078)
location: region:1647-2078:-1
so has part: feature:1647-2078:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:1647-2078:-1:exon

YOL165C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAD15
locus tag: YOL165C
note: Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family
codon start: 1
product: putative aryl-alcohol dehydrogenase
translation: MARHFGMALAPWDVMGGGRFQSKKAMEERRKNGECIRSFVGASEQTDAEIKISEALAKVAEEHGTESVTAIAIAYVRSKAKNVFPSVEGGKIEDLKENIKALSIDLTPDNIKYLENVVPFDIGFPNTFIVLNSLTQKYGTNNV
SIO_010081: YOL165C
subclass of: SO_0000673
so part of: YOL165C
location: complement(1647..2078)
location: region:1647-2078:-1
so has part: feature:1647-2078:-1:exon

NP_014477.1
type: Protein
SIO_000068: ncbiprotein

S000005525
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:1647-2078:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(2894..3223)
location: region:2894-3223:-1
so has part: feature:2894-3223:-1:region

S000007148
type: SGD
SIO_000068: sgd

position:2894:-1
position: 2894
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:3223:-1
position: 3223
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2894-3223:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 3809..3986
location: region:3809-3986:1
so has part: feature:3809-3986:1:region

S000007160
type: SGD
SIO_000068: sgd

position:3809:1
position: 3809
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:3986:1
position: 3986
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3809-3986:1:region

YOL164W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL164W-A
so part of: sequence
location: <4130..>4312
location: region:4130-4312:1
so has part: feature:4130-4312:1:exon
subclass of: SO_0000010

1466473
type: Gene
SIO_000068: ncbigene

position:4130:1
position: 4130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:4312:1
position: 4312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4130-4312:1:exon

YOL164W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL164W-A
product: uncharacterized protein
transcript id: NM_001184575.1
SIO_010081: YOL164W-A
subclass of: SO_0000673
so part of: YOL164W-A
location: <4130..>4312
location: region:4130-4312:1
so has part: feature:4130-4312:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:4130-4312:1:exon

YOL164W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL164W-A
note: hypothetical protein; identified by fungal homology and RT-PCR
codon start: 1
product: uncharacterized protein
translation: MFAKLYRGLTYVTNKILSTLLSHHSIHYCINSFKPTTLAIIILLHPCCRCNVYIIRCIHH
SIO_010081: YOL164W-A
subclass of: SO_0000673
so part of: YOL164W-A
location: 4130..4312
location: region:4130-4312:1
so has part: feature:4130-4312:1:exon

NP_878161.1
type: Protein
SIO_000068: ncbiprotein

S000028580
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:4130-4312:1:exon

YOL164W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BDS1
locus tag: YOL164W
so part of: sequence
location: <6175..>8115
location: region:6175-8115:1
so has part: feature:6175-8115:1:exon
subclass of: SO_0000010

854000
type: Gene
SIO_000068: ncbigene

position:6175:1
position: 6175
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:8115:1
position: 8115
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6175-8115:1:exon

YOL164W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BDS1
locus tag: YOL164W
product: sulfuric ester hydrolase
transcript id: NM_001183417.1
SIO_010081: YOL164W
subclass of: SO_0000673
so part of: YOL164W
location: <6175..>8115
location: region:6175-8115:1
so has part: feature:6175-8115:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6175-8115:1:exon

YOL164W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BDS1
locus tag: YOL164W
experiment: EXISTENCE:mutant phenotype:GO:0018741 alkyl sulfatase activity [PMID:15947202]
experiment: EXISTENCE:mutant phenotype:GO:0018909 dodecyl sulfate metabolic process [PMID:15947202]
note: Bacterially-derived sulfatase; required for use of alkyl sulfates as sulfur source
codon start: 1
product: sulfuric ester hydrolase
translation: MIGAFKRNRGSSQSFAKECQPSTLKANLEVAKELPFSDRRDFEDATQGYIGSLSDEQIIGPDGGVVWCMKSYGFLEPETPANTVNPSLWRQAQLNAIHGLFKITDNVYQVRGLDISNMTIIEGNTSLIIIDTLFTTETAQESLKLYYRHRPQKPVRTVIYTHSHSDHYGGVKGIVKEADVKSGEVQIIAPVGFMESVVAENILAGNAMHRRSQYQFGMLLSPSVKGHVDCGIGKAASHGTVTLIAPTIIIEEPVEERTIDGVDFVFQLAPGSEAPSEMLIYMPQQRVLNMAEDVTHHMHNLYALRGVEVRDGNQWAKYIDAARVAFGSKTDVLIAQHHWPTTGQMRINELLKKQRDMYKFIHDQTLRLLNQGYTSRDIAETLRMPSSLEQEWSTRGYYGTLSHNVKAVYQKYLGWYDANPANLNPLPPVAYAKKAVEYMGGADAVLARAYKDFQKGEFRWVASVVNQLVFADPNNHQARELCADALEQLGYQAEASTWRNAYLVGAMELRQGVPKRRSTGKRNNIAVLNNEMFFDFLAVRLNATKAEGKIIVSNWCFINSNERFVITLENCALTYIQGWQTDADATITLKRTTFEALLANEITMVDFLRSKEVEIEGNRLRIEELLKLFDDFDQSFPVVEPMGGST
SIO_010081: YOL164W
subclass of: SO_0000673
so part of: YOL164W
location: 6175..8115
location: region:6175-8115:1
so has part: feature:6175-8115:1:exon

NP_014478.1
type: Protein
SIO_000068: ncbiprotein

S000005524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6175-8115:1:exon

YOL163W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL163W
so part of: sequence
location: <9597..>10106
location: region:9597-10106:1
so has part: feature:9597-10106:1:exon
subclass of: SO_0000010

854001
type: Gene
SIO_000068: ncbigene

position:9597:1
position: 9597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:10106:1
position: 10106
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:9597-10106:1:exon

YOL163W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL163W
product: uncharacterized protein
transcript id: NM_001183416.1
SIO_010081: YOL163W
subclass of: SO_0000673
so part of: YOL163W
location: <9597..>10106
location: region:9597-10106:1
so has part: feature:9597-10106:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:9597-10106:1:exon

YOL163W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL163W
note: hypothetical protein; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL162W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family
codon start: 1
product: uncharacterized protein
translation: MIAWSLVATLQCKMTGKSSFYTCRALMGLFEGGFVADLVLWMSYFYSSSELSIRLSFFWVTLSLTQIITSIVAFGVFHMRGIGGMAGWQWLFLIERIFTLVIGISAYFLMVPSVVQTKKPWSKKGWFTEREEKIIVNKILRDDPTKGDMNNRQGMSLKMLWQGITDYYI
SIO_010081: YOL163W
subclass of: SO_0000673
so part of: YOL163W
location: 9597..10106
location: region:9597-10106:1
so has part: feature:9597-10106:1:exon

NP_014479.1
type: Protein
SIO_000068: ncbiprotein

S000005523
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:9597-10106:1:exon

YOL162W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL162W
so part of: sequence
location: <10119..>10766
location: region:10119-10766:1
so has part: feature:10119-10766:1:exon
subclass of: SO_0000010

854002
type: Gene
SIO_000068: ncbigene

position:10119:1
position: 10119
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:10766:1
position: 10766
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:10119-10766:1:exon

YOL162W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL162W
product: uncharacterized protein
transcript id: NM_001183415.1
SIO_010081: YOL162W
subclass of: SO_0000673
so part of: YOL162W
location: <10119..>10766
location: region:10119-10766:1
so has part: feature:10119-10766:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:10119-10766:1:exon

YOL162W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL162W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL163W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family
codon start: 1
product: uncharacterized protein
translation: MGLLAYIPTNVLATYLTLVLRSIGFTTFQANLLAIPNFVLHILLLFGLTWSTEKCNNRLGLSLLQPLYTVPLLAVLRFWKGTMFNKWGTYAIITLILDNPYIHAICVSLCSRNSQSVKTRTVSTCLYNMFVQAGLIISSNIYAKSDAPLYRKGNGVLFGLALFMFPILIGSKLIYVYINKQRDKRWNAMSEEEKDHYLSTTSDAGSRRLDFRFYH
SIO_010081: YOL162W
subclass of: SO_0000673
so part of: YOL162W
location: 10119..10766
location: region:10119-10766:1
so has part: feature:10119-10766:1:exon

NP_014480.1
type: Protein
SIO_000068: ncbiprotein

S000005522
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:10119-10766:1:exon

YOL161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU20
locus tag: YOL161C
so part of: sequence
location: complement(<11549..>11911)
location: region:11549-11911:-1
so has part: feature:11549-11911:-1:exon
subclass of: SO_0000010

854003
type: Gene
SIO_000068: ncbigene

position:11549:-1
position: 11549
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:11911:-1
position: 11911
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11549-11911:-1:exon

YOL161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU20
locus tag: YOL161C
product: seripauperin PAU20
transcript id: NM_001183414.1
SIO_010081: YOL161C
subclass of: SO_0000673
so part of: YOL161C
location: complement(<11549..>11911)
location: region:11549-11911:-1
so has part: feature:11549-11911:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11549-11911:-1:exon

YOL161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU20
locus tag: YOL161C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation
codon start: 1
product: seripauperin PAU20
translation: MVKLTSIAAGVAAIAAGASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGISPDQVTRMITGVPWYSTRLKPAISKALSKDGIYTIAN
SIO_010081: YOL161C
subclass of: SO_0000673
so part of: YOL161C
location: complement(11549..11911)
location: region:11549-11911:-1
so has part: feature:11549-11911:-1:exon

NP_014481.1
type: Protein
SIO_000068: ncbiprotein

S000005521
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11549-11911:-1:exon

YOL160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL160W
so part of: sequence
location: <14313..>14654
location: region:14313-14654:1
so has part: feature:14313-14654:1:exon
subclass of: SO_0000010

854004
type: Gene
SIO_000068: ncbigene

position:14313:1
position: 14313
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14654:1
position: 14654
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14313-14654:1:exon

YOL160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL160W
product: uncharacterized protein
transcript id: NM_001348873.1
SIO_010081: YOL160W
subclass of: SO_0000673
so part of: YOL160W
location: <14313..>14654
location: region:14313-14654:1
so has part: feature:14313-14654:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14313-14654:1:exon

YOL160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL160W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MENIAFICLQSCTRGIYGCQFYSATLENYHNISFPIFLLQTTLFNHCISLNWSKAVFNRIKRRKYMMELKKHCYNYQVSRIGNRKKNGCFFLKMANNRVFSVKNSPRLLLFFI
SIO_010081: YOL160W
subclass of: SO_0000673
so part of: YOL160W
location: 14313..14654
location: region:14313-14654:1
so has part: feature:14313-14654:1:exon

NP_001335811.1
type: Protein
SIO_000068: ncbiprotein

S000005520
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14313-14654:1:exon

YOL159C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL159C-A
so part of: sequence
location: complement(<15233..>15505)
location: region:15233-15505:-1
so has part: feature:15233-15505:-1:exon
subclass of: SO_0000010

854005
type: Gene
SIO_000068: ncbigene

position:15233:-1
position: 15233
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:15505:-1
position: 15505
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:15233-15505:-1:exon

YOL159C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL159C-A
product: uncharacterized protein
transcript id: NM_001184493.1
SIO_010081: YOL159C-A
subclass of: SO_0000673
so part of: YOL159C-A
location: complement(<15233..>15505)
location: region:15233-15505:-1
so has part: feature:15233-15505:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:15233-15505:-1:exon

YOL159C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL159C-A
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21777356|PMID:14562095]
note: hypothetical protein; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
codon start: 1
product: uncharacterized protein
translation: MQYCELDLSGQWLDTVYCEENFSDFVFIKFLNPSQFEEKIYCYTLHITKRTLENKRLLLYYEDEFKKHGHDINELVGDGIILRSCWNPRQ
SIO_010081: YOL159C-A
subclass of: SO_0000673
so part of: YOL159C-A
location: complement(15233..15505)
location: region:15233-15505:-1
so has part: feature:15233-15505:-1:exon

NP_076909.1
type: Protein
SIO_000068: ncbiprotein

S000007627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:15233-15505:-1:exon

YOL159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSS3
locus tag: YOL159C
so part of: sequence
location: complement(<17281..>17796)
location: region:17281-17796:-1
so has part: feature:17281-17796:-1:exon
subclass of: SO_0000010

854006
type: Gene
SIO_000068: ncbigene

position:17281:-1
position: 17281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17796:-1
position: 17796
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17281-17796:-1:exon

YOL159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSS3
locus tag: YOL159C
product: Css3p
transcript id: NM_001183412.1
SIO_010081: YOL159C
subclass of: SO_0000673
so part of: YOL159C
location: complement(<17281..>17796)
location: region:17281-17796:-1
so has part: feature:17281-17796:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17281-17796:-1:exon

YOL159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSS3
locus tag: YOL159C
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
codon start: 1
product: Css3p
translation: MVPLFGLFCIFSQLYSLCSAYVDITSGYQVFFNLPTNMTNNQICWLFQASYYDIYSDKSGRTLRTGRFEPGDQQSLIYRDTLVELEAITDSYEYSNLDLSTYNGPEPYNSETDYCTDIMDLVMRVYDEEGHYVHPVANNSTNACAHPTPPTLNNLLISNYSDGRNYKESSI
SIO_010081: YOL159C
subclass of: SO_0000673
so part of: YOL159C
location: complement(17281..17796)
location: region:17281-17796:-1
so has part: feature:17281-17796:-1:exon

NP_014483.1
type: Protein
SIO_000068: ncbiprotein

S000005519
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17281-17796:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(18302..18561)
location: region:18302-18561:-1
so has part: feature:18302-18561:-1:region

S000007149
type: SGD
SIO_000068: sgd

position:18302:-1
position: 18302
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:18561:-1
position: 18561
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:18302-18561:-1:region

YOL158C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARN4
gene: ENB1
locus tag: YOL158C
gene synonym: ARN4
so part of: sequence
location: complement(<19491..>21311)
location: region:19491-21311:-1
so has part: feature:19491-21311:-1:exon
subclass of: SO_0000010

854007
type: Gene
SIO_000068: ncbigene

position:19491:-1
position: 19491
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:21311:-1
position: 21311
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:19491-21311:-1:exon

YOL158C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARN4
gene: ENB1
locus tag: YOL158C
gene synonym: ARN4
product: Enb1p
transcript id: NM_001183411.1
SIO_010081: YOL158C
subclass of: SO_0000673
so part of: YOL158C
location: complement(<19491..>21311)
location: region:19491-21311:-1
so has part: feature:19491-21311:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:19491-21311:-1:exon

YOL158C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARN4
gene: ENB1
locus tag: YOL158C
gene synonym: ARN4
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17714436]
experiment: EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:17714436]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015620 ferric-enterobactin transmembrane transporter activity [PMID:10831226]
experiment: EXISTENCE:mutant phenotype:GO:0015685 ferric-enterobactin import into cell [PMID:10831226]
note: Ferric enterobactin transmembrane transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
codon start: 1
product: Enb1p
translation: MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRIDAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFGKHSQVGSINTVKSIVASVVAVPYARISDRFGRIECWIFALVLYTIGEIISAATPTFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLRDRTFAMNIFLIPVIINTWVSGNIVSSVAGNVAPYKWRWGYGIFCIIVPISTLILVLPYVYAQYISWRSGKLPPLKLKEKGQTLRQTLWKFADDINLIGVILFTAFLVLVLLPLTIAGGATSKWREGHIIAMIVVGGCLGFIFLIWELKFAKNPFIPRVYLGDPTIYVALLMEFVWRLGLQIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSCTNIVVGIMLHFYPHPKVFVVAGSLLGVIGMGLLYKYRVVYDGISGLIGAEIVVGIAGGMIRFPMWTLVHASTTHNEMATVTGLLMSVYQIGDAVGASIAGAIWTQRLAKELIQRLGSSLGMAIYKSPLNYLKKYPIGSEVRVQMIESYSKIQRLLIIVSISFAAFNAVLCFFLRGFTVNKKQSLSAEEREKEKLKIKQQSWLRRVIGY
SIO_010081: YOL158C
subclass of: SO_0000673
so part of: YOL158C
location: complement(19491..21311)
location: region:19491-21311:-1
so has part: feature:19491-21311:-1:exon

NP_014484.1
type: Protein
SIO_000068: ncbiprotein

S000005518
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:19491-21311:-1:exon

YOL157C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMA2
locus tag: YOL157C
so part of: sequence
location: complement(<22525..>24294)
location: region:22525-24294:-1
so has part: feature:22525-24294:-1:exon
subclass of: SO_0000010

854008
type: Gene
SIO_000068: ncbigene

position:22525:-1
position: 22525
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:24294:-1
position: 24294
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22525-24294:-1:exon

YOL157C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMA2
locus tag: YOL157C
product: oligo-1,6-glucosidase IMA2
transcript id: NM_001183410.1
SIO_010081: YOL157C
subclass of: SO_0000673
so part of: YOL157C
location: complement(<22525..>24294)
location: region:22525-24294:-1
so has part: feature:22525-24294:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:22525-24294:-1:exon

YOL157C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMA2
locus tag: YOL157C
EC number: 3.2.1.10
experiment: EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265]
experiment: EXISTENCE:direct assay:GO:0004575 sucrose alpha-glucosidase activity [PMID:24649402]
experiment: EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20562106|PMID:20471265]
experiment: EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]
note: Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose
codon start: 1
product: oligo-1,6-glucosidase IMA2
translation: MTISSAHPETEPKWWKEATIYQIYPASFKDSNNDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWRSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVAGLPDAPVIDENSKWQPSDPFTMNGPRIHEFHQEMNKFIRNRVKDGREIMTVGEMQHATDETKRLYTSASRHELSELFNFSHTDVGTSPKFRQNLIPYELKDWKVALAELFRYVNGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLVSLSGTLYVYQGQELGEINFKNWPIEKYEDVEVRNNYDAIKEEHGENSKEMKRFLEAIALISRDHARTPMQWSREEPNAGFSGPNAKPWFYLNESFREGINAEDESKDPNSVLNFWKEALRFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYDNKTLFAALNFSSDSIDFTIPNNSSSFKLEFGNYPRSEVDASSRTLKPWEGRIYISE
SIO_010081: YOL157C
subclass of: SO_0000673
so part of: YOL157C
location: complement(22525..24294)
location: region:22525-24294:-1
so has part: feature:22525-24294:-1:exon

NP_014485.1
type: Protein
SIO_000068: ncbiprotein

S000005517
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:22525-24294:-1:exon

YOL156W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LGT3
gene: HXT11
locus tag: YOL156W
gene synonym: LGT3
so part of: sequence
location: <25273..>26976
location: region:25273-26976:1
so has part: feature:25273-26976:1:exon
subclass of: SO_0000010

854009
type: Gene
SIO_000068: ncbigene

position:25273:1
position: 25273
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26976:1
position: 26976
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25273-26976:1:exon

YOL156W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LGT3
gene: HXT11
locus tag: YOL156W
gene synonym: LGT3
product: hexose transporter HXT11
transcript id: NM_001183409.1
SIO_010081: YOL156W
subclass of: SO_0000673
so part of: YOL156W
location: <25273..>26976
location: region:25273-26976:1
so has part: feature:25273-26976:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25273-26976:1:exon

YOL156W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LGT3
gene: HXT11
locus tag: YOL156W
gene synonym: LGT3
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:1902341 xylitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0005355 glucose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]
note: Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance
codon start: 1
product: hexose transporter HXT11
translation: MSGVNNTSANELSTTMSNSNSAVGAPSVKTEHGDSKNSLNLDANEPPIDLPQKPLSAYTTVAILCLMIAFGGFIFGWDTGTISGFVNLSDFIRRFGQKNDKGTYYLSKVRMGLIVSIFNIGCAIGGIVLSKVGDIYGRRIGLITVTAIYVVGILIQITSINKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKHIRGTLVQLYQLMGTMGIFLGYCTNYGTKNYHNATQWRVGLGLCFAWATFMVSGMMFVPESPRYLIEVGKDEEAKRSLSKSNKVSVDDPALLVEYDTIKAGIELEKLAGNASWSELLSTKTKVFQRVLMGVMIQSLQQLTGDNYFFYYGTTIFKSVGLKDSFQTSIIIGVVNFFSSFIAVYTIERFGRRTCLLWGAASMLCCFAVFASVGVTKLWPQGSSHQDITSQGAGNCMIVFTMFFIFSFATTWAGGCYVIVSETFPLRVKSRGMAIATAANWMWGFLISFFTPFITGAINFYYGYVFLGCLVFAYFYVFFFVPETKGLTLEEVNTMWLEGVPAWKSASWVPPERRTADYDADAIDHDNRPIYKRFFSS
SIO_010081: YOL156W
subclass of: SO_0000673
so part of: YOL156W
location: 25273..26976
location: region:25273-26976:1
so has part: feature:25273-26976:1:exon

NP_014486.1
type: Protein
SIO_000068: ncbiprotein

S000005516
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25273-26976:1:exon

YOL155W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL155W-A
so part of: sequence
location: <27084..>27218
location: region:27084-27218:1
so has part: feature:27084-27218:1:exon
subclass of: SO_0000010

1466474
type: Gene
SIO_000068: ncbigene

position:27084:1
position: 27084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27218:1
position: 27218
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27084-27218:1:exon

YOL155W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL155W-A
product: uncharacterized protein
transcript id: NM_001184666.1
SIO_010081: YOL155W-A
subclass of: SO_0000673
so part of: YOL155W-A
location: <27084..>27218
location: region:27084-27218:1
so has part: feature:27084-27218:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:27084-27218:1:exon

YOL155W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL155W-A
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MFYGSFNKCVTGYSCRMAIHYYVYRIIKSATRPDYKSNTQILVL
SIO_010081: YOL155W-A
subclass of: SO_0000673
so part of: YOL155W-A
location: 27084..27218
location: region:27084-27218:1
so has part: feature:27084-27218:1:exon

NP_878162.1
type: Protein
SIO_000068: ncbiprotein

S000028855
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:27084-27218:1:exon

YOL155C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HPF1
locus tag: YOL155C
so part of: sequence
location: complement(<28703..>31606)
location: region:28703-31606:-1
so has part: feature:28703-31606:-1:exon
subclass of: SO_0000010

854010
type: Gene
SIO_000068: ncbigene

position:28703:-1
position: 28703
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31606:-1
position: 31606
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:28703-31606:-1:exon

YOL155C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HPF1
locus tag: YOL155C
product: mannoprotein
transcript id: NM_001183408.1
SIO_010081: YOL155C
subclass of: SO_0000673
so part of: YOL155C
location: complement(<28703..>31606)
location: region:28703-31606:-1
so has part: feature:28703-31606:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:28703-31606:-1:exon

YOL155C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HPF1
locus tag: YOL155C
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11748726]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:11748726]
note: Haze-protective mannoprotein; reduces particle size of aggregated proteins in white wines, thereby decreasing turbidity; intragenic repeat expansion controls chronological aging; expansion of intragenic tandem repeats within N-terminus sufficient to cause pronounced life span shortening; repeat expansion shifts cells from sedentary to buoyant, thereby increasing exposure to oxygen, altering methionine, lipid, and purine metabolism
codon start: 1
product: mannoprotein
translation: MFNRFNKLQAALALVLYSQSALGQYYTNSSSIASNSSTAVSSTSSGSVSISSSIELTSSTSDVSSSLTELTSSSTEVSSSIAPSTSSSEVSSSITSSGSSVSGSSSITSSGSSVSSSSSATESGSSASGSSSATESGSSVSGSSTSITSGSSSATESGSSVSGSTSATESGSSASGSSSATESGSSASGSSSATESGSSVSGSSSATESGSSVSGSSSATESGSASSVPSSSGSVTESGSSSSASESSITQSGTASGSSASSTSGSVTQSGSSVSGSSASSAPGISSSIPQSTSSASTASGSITSGTLSSITSSASSATATASNSLSSSDGTIYLPSTTISGDITLTGSVIATEAVEVAAGGKLTLLDGDKYVFSADFIIHGGVFVEKSKPTYPGTEFDISGENFDVSGTFNAEEPAASSASAYSFTPGSFDNSGDISLSLSESTKGEVTFSPYSNSGAFSFSNAILNGGSVSGLQRRAESGSVNNGEINLENGSTYVVVEPVSGSGTINIISGNLYLHYPDTFTGQTVVFKGEGVLAVDPTETNTTPIPVVGYTGENQIAITADVTALSYDSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYLNYGGVVASSATPSSTSTTSGATNSTSGSTSFGASVTGSTASTSFGASVTGSTASTLISGSPSVYTTTLTYATTTSTVVVSCSETTDSNGNVYTITTTVPCSSTTATITSCDETGCHVTTSTGTVATETVSSKSYTTVTVTHCDNNGCNTKTVTSECPEETSATTTSPKSYTTVTVTHCDDNGCNTKTVTSEAPEATTTTVSPKTYTTATVTQCDDNGCSTKTVTSEAPKETSETSETSAAPKTYTTATVTQCDDNGCNVKIITSQIPEATSTVTATSASPKSYTTVTSEGSKATSLTTAISKASSAISTYSKSAAPIKTSTGIIVQSEGIAAGLNANTLNALVGIFVLAFFN
SIO_010081: YOL155C
subclass of: SO_0000673
so part of: YOL155C
location: complement(28703..31606)
location: region:28703-31606:-1
so has part: feature:28703-31606:-1:exon

NP_014487.1
type: Protein
SIO_000068: ncbiprotein

S000005515
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:28703-31606:-1:exon

YOL154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZPS1
locus tag: YOL154W
so part of: sequence
location: <34658..>35407
location: region:34658-35407:1
so has part: feature:34658-35407:1:exon
subclass of: SO_0000010

854011
type: Gene
SIO_000068: ncbigene

position:34658:1
position: 34658
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:35407:1
position: 35407
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34658-35407:1:exon

YOL154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZPS1
locus tag: YOL154W
product: Zps1p
transcript id: NM_001183407.1
SIO_010081: YOL154W
subclass of: SO_0000673
so part of: YOL154W
location: <34658..>35407
location: region:34658-35407:1
so has part: feature:34658-35407:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34658-35407:1:exon

YOL154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZPS1
locus tag: YOL154W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
codon start: 1
product: Zps1p
translation: MKFSSGKSIIFATIASLALSAPVTYDTNSTAELQSPSSQEILGWSHATFPTIYQTCNETNARMLNAAFKDTAEITAYGKDRLLNYGVDDVYYKRWFGNGSIFTVMGVFEQLMEASKGAMLMRCDDIDGLCAANPNYYAGHHRQSAPAETVICDYFYTSKKPLSTICFEGTIVDVGPKHYAGIDMLHRYLHVPTMSMDGYVGEYAETLEEVVDYTQNNATYAVRNTDNYLYYLADVYSASVIPGGCLGNL
SIO_010081: YOL154W
subclass of: SO_0000673
so part of: YOL154W
location: 34658..35407
location: region:34658-35407:1
so has part: feature:34658-35407:1:exon

NP_014488.1
type: Protein
SIO_000068: ncbiprotein

S000005514
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34658-35407:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1531; Autonomously Replicating Sequence
so part of: sequence
location: 35669..35904
location: region:35669-35904:1
so has part: feature:35669-35904:1:region

S000118995
type: SGD
SIO_000068: sgd

position:35669:1
position: 35669
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:35904:1
position: 35904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35669-35904:1:region

YOL153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL153C
pseudo: true
so part of: sequence
location: complement(36822..38567)
location: region:36822-38567:-1
so has part: feature:36822-38567:-1:exon

854012
type: Gene
SIO_000068: ncbigene

position:36822:-1
position: 36822
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:38567:-1
position: 38567
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36822-38567:-1:exon

YOL153C
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
locus tag: YOL153C
note: Blocked reading frame, contains two in-frame stops in translation; this ORF is conserved, without the stops, in Saccharomyces paradoxus, S. mikatae, and S. bayanus; RNA sequencing data indicate the presence of a transcription unit at this reading frame
pseudo: true
SIO_010081: YOL153C
subclass of: SO_0000673
so part of: YOL153C
location: complement(36822..38567)
location: region:36822-38567:-1
so has part: feature:36822-38567:-1:exon

S000005513
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36822-38567:-1:exon

YOL152W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRE7
locus tag: YOL152W
so part of: sequence
location: <40748..>42610
location: region:40748-42610:1
so has part: feature:40748-42610:1:exon
subclass of: SO_0000010

854013
type: Gene
SIO_000068: ncbigene

position:40748:1
position: 40748
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42610:1
position: 42610
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40748-42610:1:exon

YOL152W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRE7
locus tag: YOL152W
product: putative ferric-chelate reductase
transcript id: NM_001183406.1
SIO_010081: YOL152W
subclass of: SO_0000673
so part of: YOL152W
location: <40748..>42610
location: region:40748-42610:1
so has part: feature:40748-42610:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40748-42610:1:exon

YOL152W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRE7
locus tag: YOL152W
EC number: 1.16.1.9
experiment: EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:17681937]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17553781]
experiment: EXISTENCE:genetic interaction:GO:0000293 ferric-chelate reductase activity [PMID:17553781]
experiment: EXISTENCE:genetic interaction:GO:0006826 iron ion transport [PMID:17553781]
experiment: EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:17553781]
note: Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
codon start: 1
product: putative ferric-chelate reductase
translation: MIEERDLVLSNGIHCIADIHSELYARLKKESQAATPWVYQKQYGKFVTYFVAVIIFLSLIKKLAFMYYDSSEEFLPEKKNSPTTPSVFLARIMTKLVAFNRYICYRKFPTLIFSYLGIPTSVGTFLVVMATTLYTLLYCFVPHPFYRPCAGFGSPPLSVRAGIMAISLVPFVFSLSGKINVIGWLVGLSYEKINIYHQWASILCLFFSWVHVIPFLRQARHEGGYERMHQRWKASDMWRSGVPPILFLNLLWLSSLPIARRHFYEIFLQLHWILAVGFYISLFYHVYPELNSHMYLVATIVVWFAQLFYRLAVKGYLRPGRSFMASTIANVSIVGEGCVELIVKDVEMAYSPGQHIFVRTIDKGIISNHPFSIFPSAKYPGGIKMLIRAQKGFSKRLYESNDDMKKILIDGPYGGIERDIRSFTNVYLICSGSGISTCLPFLQKYGPILHKTNLEVITLDWVVRHREDISWIRDEMCTLSNNLRQLFLDGKIVVRIYVCSDSTVPGIIKTFPQTIDTASDQSDLAKREKDTEFGQDDTESNSTFDKSNNEYKGLITIIPSKPDLNQVINDYQIGFRNCFICSGSDSLRYTVGNSVAGLQAKVFSNKNVEECYLHSESFGY
SIO_010081: YOL152W
subclass of: SO_0000673
so part of: YOL152W
location: 40748..42610
location: region:40748-42610:1
so has part: feature:40748-42610:1:exon

NP_014489.2
type: Protein
SIO_000068: ncbiprotein

S000005512
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40748-42610:1:exon

YOL151W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRE2
locus tag: YOL151W
so part of: sequence
location: <43694..>44722
location: region:43694-44722:1
so has part: feature:43694-44722:1:exon
subclass of: SO_0000010

854014
type: Gene
SIO_000068: ncbigene

position:43694:1
position: 43694
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:44722:1
position: 44722
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:43694-44722:1:exon

YOL151W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRE2
locus tag: YOL151W
product: methylglyoxal reductase (NADPH-dependent) GRE2
transcript id: NM_001183405.1
SIO_010081: YOL151W
subclass of: SO_0000673
so part of: YOL151W
location: <43694..>44722
location: region:43694-44722:1
so has part: feature:43694-44722:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:43694-44722:1:exon

YOL151W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRE2
locus tag: YOL151W
EC number: 1.1.1.265
EC number: 1.1.1.283
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12206772]
experiment: EXISTENCE:direct assay:GO:0043892 methylglyoxal reductase (NADPH-dependent) activity [PMID:12722185]
experiment: EXISTENCE:genetic interaction:GO:0008204 ergosterol metabolic process [PMID:16598690]
experiment: EXISTENCE:mutant phenotype:GO:0008204 ergosterol metabolic process [PMID:16598690]
experiment: EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:16999827]
experiment: EXISTENCE:mutant phenotype:GO:0046568 3-methylbutanol:NAD(P) oxidoreductase activity [PMID:16999827]
note: 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase
codon start: 1
product: methylglyoxal reductase (NADPH-dependent) GRE2
translation: MSVFVSGANGFIAQHIVDLLLKEDYKVIGSARSQEKAENLTEAFGNNPKFSMEVVPDISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIKKYAADSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAAWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPELFGGYIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILNEDFPVLKGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFRNLKETIDDTASQILKFEGRI
SIO_010081: YOL151W
subclass of: SO_0000673
so part of: YOL151W
location: 43694..44722
location: region:43694-44722:1
so has part: feature:43694-44722:1:exon

NP_014490.1
type: Protein
SIO_000068: ncbiprotein

S000005511
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:43694-44722:1:exon

YOL149W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MRT2
gene: DCP1
locus tag: YOL149W
gene synonym: MRT2
so part of: sequence
location: <44938..>45633
location: region:44938-45633:1
so has part: feature:44938-45633:1:exon
subclass of: SO_0000010

854016
type: Gene
SIO_000068: ncbigene

position:44938:1
position: 44938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45633:1
position: 45633
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:44938-45633:1:exon

YOL149W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MRT2
gene: DCP1
locus tag: YOL149W
gene synonym: MRT2
product: Dcp1p
transcript id: NM_001183403.1
SIO_010081: YOL149W
subclass of: SO_0000673
so part of: YOL149W
location: <44938..>45633
location: region:44938-45633:1
so has part: feature:44938-45633:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:44938-45633:1:exon

YOL149W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MRT2
gene: DCP1
locus tag: YOL149W
gene synonym: MRT2
experiment: EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:11139489]
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23509072|PMID:12730603]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11139489]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16341225]
experiment: EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]
experiment: EXISTENCE:direct assay:GO:0098745 Dcp1-Dcp2 complex [PMID:12554866]
experiment: EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]
experiment: EXISTENCE:physical interaction:GO:0098745 Dcp1-Dcp2 complex [PMID:10508173]
note: Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: Dcp1p
translation: MTGAATAAENSATQLEFYRKALNFNVIGRYDPKIKQLLFHTPHASLYKWDFKKDEWNKLEYQGVLAIYLRDVSQNTNLLPVSPQEVDIFDSQNGSNNIQVNNGSDNSNRNSSGNGNSYKSNDSLTYNCGKTLSGKDIYNYGLIILNRINPDNFSMGIVPNSVVNKRKVFNAEEDTLNPLECMGVEVKDELVIIKNLKHEVYGIWIHTVSDRQNIYELIKYLLENEPKDSFA
SIO_010081: YOL149W
subclass of: SO_0000673
so part of: YOL149W
location: 44938..45633
location: region:44938-45633:1
so has part: feature:44938-45633:1:exon

NP_014492.1
type: Protein
SIO_000068: ncbiprotein

S000005509
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:44938-45633:1:exon

YOL148C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ADA5
gene: SPT20
locus tag: YOL148C
gene synonym: ADA5
so part of: sequence
location: complement(<45760..>47574)
location: region:45760-47574:-1
so has part: feature:45760-47574:-1:exon
subclass of: SO_0000010

854017
type: Gene
SIO_000068: ncbigene

position:45760:-1
position: 45760
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:47574:-1
position: 47574
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45760-47574:-1:exon

YOL148C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ADA5
gene: SPT20
locus tag: YOL148C
gene synonym: ADA5
product: Spt20p
transcript id: NM_001183402.1
SIO_010081: YOL148C
subclass of: SO_0000673
so part of: YOL148C
location: complement(<45760..>47574)
location: region:45760-47574:-1
so has part: feature:45760-47574:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45760-47574:-1:exon

YOL148C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ADA5
gene: SPT20
locus tag: YOL148C
gene synonym: ADA5
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9224714|PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]
experiment: EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:8649430]
experiment: EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:10652329]
note: Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
codon start: 1
product: Spt20p
translation: MSANSPTGNDPHVFGIPVNATPSNMGSPGSPVNVPPPMNPAVANVNHPVMRTNSNSNANEGTRTLTREQIQQLQQRQRLLLQQRLLEQQRKQQALQNYEAQFYQMLMTLNKRPKRLYNFVEDADSILKKYEQYLHSFEFHIYENNYKICAPANSRLQQQQKQPELTSDGLILTKNNETLKEFLEYVARGRIPDAIMEVLRDCNIQFYEGNLILQVYDHTNTVDVTPKENKPNLNSSSSPSNNNSTQDNSKIQQPSEPNSGVANTGANTANKKASFKRPRVYRTLLKPNDLTTYYDMMSYADNARFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLEETAFSEPHWDSEKKSFIHEHRAESTREGTKGVVGHIEERDEFPQHSSNYEQLMLIMNERTTTITNSTFAVSLTKNAMEIASSSSNGVRGASSSTSNSASNTRNNSLANGNQVALAAAAAAAAVGSTMGNDNNQFSRLKFIEQWRINKEKRKQQALSANINPTPFNARISMTAPLTPQQQLLQRQQQALEQQQNGGAMKNANKRSGNNATSNNNNNNNNLDKPKVKRPRKNAKKSESGTPAPKKKRMTKKKQSASSTPSSTTMS
SIO_010081: YOL148C
subclass of: SO_0000673
so part of: YOL148C
location: complement(45760..47574)
location: region:45760-47574:-1
so has part: feature:45760-47574:-1:exon

NP_014493.1
type: Protein
SIO_000068: ncbiprotein

S000005508
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45760-47574:-1:exon

YOL147C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PMP24
alternative label: PMP27
gene: PEX11
locus tag: YOL147C
gene synonym: PMP24; PMP27
so part of: sequence
location: complement(<47933..>48643)
location: region:47933-48643:-1
so has part: feature:47933-48643:-1:exon
subclass of: SO_0000010

854018
type: Gene
SIO_000068: ncbigene

position:47933:-1
position: 47933
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48643:-1
position: 48643
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:47933-48643:-1:exon

YOL147C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PMP24
alternative label: PMP27
gene: PEX11
locus tag: YOL147C
gene synonym: PMP24; PMP27
product: Pex11p
transcript id: NM_001183401.1
SIO_010081: YOL147C
subclass of: SO_0000673
so part of: YOL147C
location: complement(<47933..>48643)
location: region:47933-48643:-1
so has part: feature:47933-48643:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:47933-48643:-1:exon

YOL147C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PMP24
alternative label: PMP27
gene: PEX11
locus tag: YOL147C
gene synonym: PMP24; PMP27
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:7860627|PMID:7721939]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20028986]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]
experiment: EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:7721939|PMID:7860627]
experiment: EXISTENCE:mutant phenotype:GO:0019395 fatty acid oxidation [PMID:10931862]
note: Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
codon start: 1
product: Pex11p
translation: MVCDTLVYHPSVTRFVKFLDGSAGREKVLRLLQYLARFLAVQNSSLLARQLQAQFTTVRKFLRFLKPLNHLQAAAKFYDNKLASDNVVRVCNVLKNIFFAAYLSLDQVNLLRILKVIPVTVLTGKKIPRWSNWCWLFGLLSGLAMDLRKIQTSHAQIAAFVKAKSQSQGDEHEDHKKVLGKAYQDRYTALRRLFWDAADSFIVLNNLGYLSSNEEYVALSGVVTSILGMQDMWKAT
SIO_010081: YOL147C
subclass of: SO_0000673
so part of: YOL147C
location: complement(47933..48643)
location: region:47933-48643:-1
so has part: feature:47933-48643:-1:exon

NP_014494.1
type: Protein
SIO_000068: ncbiprotein

S000005507
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:47933-48643:-1:exon

YOL146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSF3
locus tag: YOL146W
so part of: sequence
location: <48864..>49448
location: region:48864-49448:1
so has part: feature:48864-49448:1:exon
subclass of: SO_0000010

854019
type: Gene
SIO_000068: ncbigene

position:48864:1
position: 48864
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:49448:1
position: 49448
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48864-49448:1:exon

YOL146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSF3
locus tag: YOL146W
product: DNA replication protein PSF3
transcript id: NM_001183400.1
SIO_010081: YOL146W
subclass of: SO_0000673
so part of: YOL146W
location: <48864..>49448
location: region:48864-49448:1
so has part: feature:48864-49448:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48864-49448:1:exon

YOL146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSF3
locus tag: YOL146W
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]
experiment: EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12730134]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12768207|PMID:12730134]
experiment: EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]
note: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
codon start: 1
product: DNA replication protein PSF3
translation: MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGDEALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKELANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHESYKDTKRWMFKK
SIO_010081: YOL146W
subclass of: SO_0000673
so part of: YOL146W
location: 48864..49448
location: region:48864-49448:1
so has part: feature:48864-49448:1:exon

NP_014495.2
type: Protein
SIO_000068: ncbiprotein

S000005506
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48864-49448:1:exon

YOL145C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDP1
gene: CTR9
locus tag: YOL145C
gene synonym: CDP1
so part of: sequence
location: complement(<49555..>52788)
location: region:49555-52788:-1
so has part: feature:49555-52788:-1:exon
subclass of: SO_0000010

854020
type: Gene
SIO_000068: ncbigene

position:49555:-1
position: 49555
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52788:-1
position: 52788
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:49555-52788:-1:exon

YOL145C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDP1
gene: CTR9
locus tag: YOL145C
gene synonym: CDP1
product: Ctr9p
transcript id: NM_001183399.2
SIO_010081: YOL145C
subclass of: SO_0000673
so part of: YOL145C
location: complement(<49555..>52788)
location: region:49555-52788:-1
so has part: feature:49555-52788:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:49555-52788:-1:exon

YOL145C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDP1
gene: CTR9
locus tag: YOL145C
gene synonym: CDP1
experiment: EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:15531585]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10219085|PMID:10684247|PMID:15643076]
experiment: EXISTENCE:direct assay:GO:0045142 triplex DNA binding [PMID:11058104]
experiment: EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]
experiment: EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]
experiment: EXISTENCE:genetic interaction:GO:0006360 transcription by RNA polymerase I [PMID:20299458]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11927560]
experiment: EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]
experiment: EXISTENCE:mutant phenotype:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:10219085]
experiment: EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]
experiment: EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]
experiment: EXISTENCE:mutant phenotype:GO:0006362 transcription elongation by RNA polymerase I [PMID:19164765]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]
experiment: EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:16246725]
experiment: EXISTENCE:mutant phenotype:GO:0060260 regulation of transcription initiation by RNA polymerase II [PMID:18194564]
experiment: EXISTENCE:mutant phenotype:GO:1901525 negative regulation of mitophagy [PMID:31525119]
experiment: EXISTENCE:mutant phenotype:GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [PMID:18469135]
experiment: EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:11884586]
experiment: EXISTENCE:physical interaction:GO:0003712 transcription coregulator activity [PMID:11927560]
experiment: EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:10219085|PMID:11884586|PMID:11927560]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11927560]
note: Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
codon start: 1
product: Ctr9p
translation: MTNAMKVEGYPSMEWPTSLDIPLKASEELVGIDLETDLPDDPTDLKTLLVEENSEKEHWLTIALAYCNHGKTNEGIKLIEMALDVFQNSERASLHTFLTWAHLNLAKGQSLSVETKEHELTQAELNLKDAIGFDPTWIGNMLATVELYYQRGHYDKALETSDLFVKSIHAEDHRSGRQSKPNCLFLLLRAKLLYQKKNYMASLKIFQELLVINPVLQPDPRIGIGLCFWQLKDSKMAIKSWQRALQLNPKNTSASILVLLGEFRESFTNSTNDKTFKEAFTKALSDLNNIFSENQHNPVLLTLLQTYYYFKGDYQTVLDIYHHRILKMSPMIAKIVLSESSFWCGRAHYALGDYRKSFIMFQESLKKNEDNLLAKLGLGQTQIKNNLLEESIITFENLYKTNESLQELNYILGMLYAGKAFDAKTAKNTSAKEQSNLNEKALKYLERYLKLTLATKNQLVISRAYLVISQLYELQNQYKTSLDYLSKALEEMEFIKKEIPLEVLNNLACYHFINGDFIKADDLFKQAKAKVSDKDESVNITLEYNIARTNEKNDCEKSESIYSQVTSLHPAYIAARIRNLYLKFAQSKIEDSDMSTEMNKLLDLNKSDLEIRSFYGWYLKNSKERKNNEKSTTHNKETLVKYNSHDAYALISLANLYVTIARDGKKSRNPKEQEKSKHSYLKAIQLYQKVLQVDPFNIFAAQGLAIIFAESKRLGPALEILRKVRDSLDNEDVQLNLAHCYLEMREYGKAIENYELVLKKFDNEKTRPHILNLLGRAWYARAIKERSVNFYQKALENAKTALDLFVKESSKSKFIHSVKFNIALLHFQIAETLRRSNPKFRTVQQIKDSLEGLKEGLELFRELNDLKEFNMIPKEELEQRIQLGETTMKSALERSLNEQEEFEKEQSAKIDEARKILEENELKEQGWMKQEEEARRLKLEKQAEEYRKLQDEAQKLIQEREAMAISEHNVKDDSDLSDKDNEYDEEKPRQKRKRSTKTKNSGESKRRKAAKKTLSDSDEDDDDVVKKPSHNKGKKSQLSNEFIEDSDEEEAQMSGSEQNKNDDNDENNDNDDNDGLF
SIO_010081: YOL145C
subclass of: SO_0000673
so part of: YOL145C
location: complement(49555..52788)
location: region:49555-52788:-1
so has part: feature:49555-52788:-1:exon

NP_014496.2
type: Protein
SIO_000068: ncbiprotein

S000005505
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:49555-52788:-1:exon

YOL144W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP8
locus tag: YOL144W
so part of: sequence
location: <53098..>54552
location: region:53098-54552:1
so has part: feature:53098-54552:1:exon
subclass of: SO_0000010

854021
type: Gene
SIO_000068: ncbigene

position:53098:1
position: 53098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:54552:1
position: 54552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53098-54552:1:exon

YOL144W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP8
locus tag: YOL144W
product: Nop8p
transcript id: NM_001183398.1
SIO_010081: YOL144W
subclass of: SO_0000673
so part of: YOL144W
location: <53098..>54552
location: region:53098-54552:1
so has part: feature:53098-54552:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53098-54552:1:exon

YOL144W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP8
locus tag: YOL144W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9891085]
experiment: EXISTENCE:direct assay:GO:0008428 ribonuclease inhibitor activity [PMID:21747919]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9891085]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:9891085]
note: Nucleolar protein required for 60S ribosomal subunit biogenesis
codon start: 1
product: Nop8p
translation: MDSVIQKRIFVGNIFHNADDCYSELLDRFGKFGDCQDFQFEKHNHFAFIDIRFNDEADFNKLRKSFNNVKFKGNILKVDEAKPNWESTWAVQHAKDLKEDIILNAKMKKKNWQHYKKMENVAKSWKDHKEVIAGRMREAPRKRSQLRNITFRINVNGSLKVYKCYKTKLWGYERNKELNDLVYKFTNNFWKNGYNHIVDRLDYSRAVKTVRFKNGLKQLTVSKDENVCSGEMDSDENMSEEEKEKNNVILNDLLKDFDFDKPMTLNDSDEELLTEQRKGEEEEEEEEEKEVNAPEYENVNKTKDQSTLPQEKPEERKEQDEGDGQEDNEFIPTFTKEIGQGTISNTETLRNLFNPNEAEPVSQFKLIEDSDNDIDHAKDVDVNQLEEEVSKSSDTLGLTSAPVPHVSRDKDNKNFLFFPHLQSPFLVGQTQLSKVRAPGRETMLSNWDEEFWANRGNWTRDMRRKMKDALKHRKRKQSKSGLLL
SIO_010081: YOL144W
subclass of: SO_0000673
so part of: YOL144W
location: 53098..54552
location: region:53098-54552:1
so has part: feature:53098-54552:1:exon

NP_014497.1
type: Protein
SIO_000068: ncbiprotein

S000005504
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53098-54552:1:exon

YOL143C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIB4
locus tag: YOL143C
so part of: sequence
location: complement(<54595..>55104)
location: region:54595-55104:-1
so has part: feature:54595-55104:-1:exon
subclass of: SO_0000010

854022
type: Gene
SIO_000068: ncbigene

position:54595:-1
position: 54595
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55104:-1
position: 55104
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54595-55104:-1:exon

YOL143C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIB4
locus tag: YOL143C
product: lumazine synthase RIB4
transcript id: NM_001183397.1
SIO_010081: YOL143C
subclass of: SO_0000673
so part of: YOL143C
location: complement(<54595..>55104)
location: region:54595-55104:-1
so has part: feature:54595-55104:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54595-55104:-1:exon

YOL143C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIB4
locus tag: YOL143C
EC number: 2.5.1.78
experiment: EXISTENCE:direct assay:GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity [PMID:7559556]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:5366000|PMID:7559556]
note: Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase
codon start: 1
product: lumazine synthase RIB4
translation: MAVKGLGKPDQVYDGSKIRVGIIHARWNRVIIDALVKGAIERMASLGVEENNIIIETVPGSYELPWGTKRFVDRQAKLGKPLDVVIPIGVLIKGSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAHSMHNHGEDWGAAAVEMAVKFGKNAF
SIO_010081: YOL143C
subclass of: SO_0000673
so part of: YOL143C
location: complement(54595..55104)
location: region:54595-55104:-1
so has part: feature:54595-55104:-1:exon

NP_014498.1
type: Protein
SIO_000068: ncbiprotein

S000005503
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54595-55104:-1:exon

YOL142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MTR14
gene: RRP40
locus tag: YOL142W
gene synonym: MTR14
so part of: sequence
location: <55558..>56280
location: region:55558-56280:1
so has part: feature:55558-56280:1:exon
subclass of: SO_0000010

854023
type: Gene
SIO_000068: ncbigene

position:55558:1
position: 55558
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:56280:1
position: 56280
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:55558-56280:1:exon

YOL142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MTR14
gene: RRP40
locus tag: YOL142W
gene synonym: MTR14
product: exosome non-catalytic core subunit RRP40
transcript id: NM_001183396.2
SIO_010081: YOL142W
subclass of: SO_0000673
so part of: YOL142W
location: <55558..>56280
location: region:55558-56280:1
so has part: feature:55558-56280:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:55558-56280:1:exon

YOL142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MTR14
gene: RRP40
locus tag: YOL142W
gene synonym: MTR14
experiment: EXISTENCE:curator inference:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0043628 regulatory ncRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070651 nonfunctional rRNA decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:17391830]
experiment: EXISTENCE:direct assay:GO:0030145 manganese ion binding [PMID:17159918]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:17643380]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]
note: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration
codon start: 1
product: exosome non-catalytic core subunit RRP40
translation: MSTFIFPGDSFPVDPTTPVKLGPGIYCDPNTQEIRPVNTGVLHVSAKGKSGVQTAYIDYSSKRYIPSVNDFVIGVIIGTFSDSYKVSLQNFSSSVSLSYMAFPNASKKNRPTLQVGDLVYARVCTAEKELEAEIECFDSTTGRDAGFGILEDGMIIDVNLNFARQLLFNNDFPLLKVLAAHTKFEVAIGLNGKIWVKCEELSNTLACYRTIMECCQKNDTAAFKDIAKRQFKEILTVKEE
SIO_010081: YOL142W
subclass of: SO_0000673
so part of: YOL142W
location: 55558..56280
location: region:55558-56280:1
so has part: feature:55558-56280:1:exon

NP_014499.2
type: Protein
SIO_000068: ncbiprotein

S000005502
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:55558-56280:1:exon

YOL141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TYW4
gene: PPM2
locus tag: YOL141W
gene synonym: TYW4
so part of: sequence
location: <56452..>58539
location: region:56452-58539:1
so has part: feature:56452-58539:1:exon
subclass of: SO_0000010

854024
type: Gene
SIO_000068: ncbigene

position:56452:1
position: 56452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58539:1
position: 58539
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56452-58539:1:exon

YOL141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TYW4
gene: PPM2
locus tag: YOL141W
gene synonym: TYW4
product: tRNA methyltransferase PPM2
transcript id: NM_001183395.2
SIO_010081: YOL141W
subclass of: SO_0000673
so part of: YOL141W
location: <56452..>58539
location: region:56452-58539:1
so has part: feature:56452-58539:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56452-58539:1:exon

YOL141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TYW4
gene: PPM2
locus tag: YOL141W
gene synonym: TYW4
EC number: 2.1.1.290
EC number: 2.3.1.231
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0008175 tRNA methyltransferase activity [PMID:16642040]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0008175 tRNA methyltransferase activity [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:17150819|PMID:16642040]
note: AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
codon start: 1
product: tRNA methyltransferase PPM2
translation: MKNLTTIKQTNKNVKQERRKKYADLAIQGTNNSSIASKRSVELLYLPKLSSANNFQMDKNNKLLEYFKFFVPKKIKRSPCINRGYWLRLFAIRSRLNSIIEQTPQDKKIVVVNLGCGYDPLPFQLLDTNNIQSQQYHDRVSFIDIDYSDLLKIKIELIKTIPELSKIIGLSEDKDYVDDSNVDFLTTPKYLARPCDLNDSKMFSTLLNECQLYDPNVVKVFVAEVSLAYMKPERSDSIIEATSKMENSHFIILEQLIPKGPFEPFSKQMLAHFKRNDSPLQSVLKYNTIESQVQRFNKLGFAYVNVGDMFQLWESADEATKKELLKVEPFDELEEFHLFCHHYVLCHATNYKEFAFTQGFLFDRSISEINLTVDEDYQLLECECPINRKFGDVDVAGNDVFYMGGSNPYRVNEILQLSIHYDKIDMKNIEVSSSEVPVARMCHTFTTISRNNQLLLIGGRKAPHQGLSDNWIFDMKTREWSMIKSLSHTRFRHSACSLPDGNVLILGGVTEGPAMLLYNVTEEIFKDVTPKDEFFQNSLVSAGLEFDPVSKQGIILGGGFMDQTTVSDKAIIFKYDAENATEPITVIKKLQHPLFQRYGSQIKYITPRKLLIVGGTSPSGLFDRTNSIISLDPLSETLTSIPISRRIWEDHSLMLAGFSLVSTSMGTIHIIGGGATCYGFGSVTNVGLKLIAIAK
SIO_010081: YOL141W
subclass of: SO_0000673
so part of: YOL141W
location: 56452..58539
location: region:56452-58539:1
so has part: feature:56452-58539:1:exon

NP_014500.2
type: Protein
SIO_000068: ncbiprotein

S000005501
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56452-58539:1:exon

misc_feature
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
note: ETC2; Chromosome-organizing-clamp; tethers chromosomal regions to the nuclear periphery; binds TFIIIC transcription factor but does not recruit RNA Polymerase III; can act as a transcription-blocking insulator or as a heterochromatin barrier element; remains predominantly localized to the nuclear periphery throughout cell cycle; located between PPM2 and ARG8
so part of: sequence
location: 58541..58563
location: region:58541-58563:1
so has part: feature:58541-58563:1:region

S000077073
type: SGD
SIO_000068: sgd

position:58541:1
position: 58541
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:58563:1
position: 58563
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58541-58563:1:region

YOL140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARG8
locus tag: YOL140W
so part of: sequence
location: <58759..>60030
location: region:58759-60030:1
so has part: feature:58759-60030:1:exon
subclass of: SO_0000010

854025
type: Gene
SIO_000068: ncbigene

position:58759:1
position: 58759
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:60030:1
position: 60030
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58759-60030:1:exon

YOL140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARG8
locus tag: YOL140W
product: acetylornithine transaminase
transcript id: NM_001183394.1
SIO_010081: YOL140W
subclass of: SO_0000673
so part of: YOL140W
location: <58759..>60030
location: region:58759-60030:1
so has part: feature:58759-60030:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:58759-60030:1:exon

YOL140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARG8
locus tag: YOL140W
EC number: 2.6.1.11
experiment: EXISTENCE:direct assay:GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [PMID:2199330]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]
note: Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
codon start: 1
product: acetylornithine transaminase
translation: MFKRYLSSTSSRRFTSILEEKAFQVTTYSRPEDLCITRGKNAKLYDDVNGKEYIDFTAGIAVTALGHANPKVAEILHHQANKLVHSSNLYFTKECLDLSEKIVEKTKQFGGQHDASRVFLCNSGTEANEAALKFAKKHGIMKNPSKQGIVAFENSFHGRTMGALSVTWNSKYRTPFGDLVPHVSFLNLNDEMTKLQSYIETKKDEIAGLIVEPIQGEGGVFPVEVEKLTGLKKICQDNDVIVIHDEIQCGLGRSGKLWAHAYLPSEAHPDIFTSAKALGNGFPIAATIVNEKVNNALRVGDHGTTYGGNPLACSVSNYVLDTIADEAFLKQVSKKSDILQKRLREIQAKYPNQIKTIRGKGLMLGAEFVEPPTEVIKKARELGLLIITAGKSTVRFVPALTIEDELIEEGMDAFEKAIEAVYA
SIO_010081: YOL140W
subclass of: SO_0000673
so part of: YOL140W
location: 58759..60030
location: region:58759-60030:1
so has part: feature:58759-60030:1:exon

NP_014501.1
type: Protein
SIO_000068: ncbiprotein

S000005500
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:58759-60030:1:exon

YOL139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TIF45
gene: CDC33
locus tag: YOL139C
gene synonym: TIF45
so part of: sequence
location: complement(<60383..>61024)
location: region:60383-61024:-1
so has part: feature:60383-61024:-1:exon
subclass of: SO_0000010

854026
type: Gene
SIO_000068: ncbigene

position:60383:-1
position: 60383
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:61024:-1
position: 61024
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:60383-61024:-1:exon

YOL139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TIF45
gene: CDC33
locus tag: YOL139C
gene synonym: TIF45
product: translation initiation factor eIF4E
transcript id: NM_001183393.1
SIO_010081: YOL139C
subclass of: SO_0000673
so part of: YOL139C
location: complement(<60383..>61024)
location: region:60383-61024:-1
so has part: feature:60383-61024:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:60383-61024:-1:exon

YOL139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TIF45
gene: CDC33
locus tag: YOL139C
gene synonym: TIF45
experiment: EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:15753296]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8119957]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8119957]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:17908917|PMID:18981231|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:15753296]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]
experiment: EXISTENCE:direct assay:GO:0098808 mRNA cap binding [PMID:24183571]
experiment: EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017]
experiment: EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2540596]
note: Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant
codon start: 1
product: translation initiation factor eIF4E
translation: MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQNIPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSFQLRGKGADIDELWLRTLLAVIGETIDEDDSQINGVVLSIRKGGNKFALWTKSEDKEPLLRIGGKFKQVLKLTDDGHLEFFPHSSANGRHPQPSITL
SIO_010081: YOL139C
subclass of: SO_0000673
so part of: YOL139C
location: complement(60383..61024)
location: region:60383-61024:-1
so has part: feature:60383-61024:-1:exon

NP_014502.1
type: Protein
SIO_000068: ncbiprotein

S000005499
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:60383-61024:-1:exon

YOL138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEA2
gene: RTC1
locus tag: YOL138C
gene synonym: SEA2
so part of: sequence
location: complement(<61325..>65350)
location: region:61325-65350:-1
so has part: feature:61325-65350:-1:exon
subclass of: SO_0000010

853982
type: Gene
SIO_000068: ncbigene

position:61325:-1
position: 61325
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65350:-1
position: 65350
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61325-65350:-1:exon

YOL138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEA2
gene: RTC1
locus tag: YOL138C
gene synonym: SEA2
product: Rtc1p
transcript id: NM_001183392.2
SIO_010081: YOL138C
subclass of: SO_0000673
so part of: YOL138C
location: complement(<61325..>65350)
location: region:61325-65350:-1
so has part: feature:61325-65350:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:61325-65350:-1:exon

YOL138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEA2
gene: RTC1
locus tag: YOL138C
gene synonym: SEA2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]
experiment: EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:23716719]
note: Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1
codon start: 1
product: Rtc1p
translation: MSLSPHVENASIPKGSTPIPKNRNVSSIGKGEFLGSSSSNNSSFRMNHYSNSGQPSVLDSIRRPNLTPTFSYSNGVYMPESHRTSSFNDSYLPYDKNPYAKTTGSMSNKSNMKIKTKKNAINTNTRKSSGLIYTTKVDKELSSIDKVNDPNINGLVCAGKTHLGLYKFSPSDRSIKCVHDFITPNSNTSTRGTTSLLPKLSKRTRQNKFSTIADVKTGFNNYKNCIAVCNNSTAISIYDLNKSSSIDNPLITSLCEHTRSINSFDFNMVESNLIISGGQDSCVKIWDLRSNKSKSSNRSDISINTASDSIRDVKWMPGYNFASKNDQGSSTYGNLKSGYKFASIHDSGYLLKFDLRQPAQYEKKLNAHTGPGLCLNWHPNQEYIATGGRDGKCCLWFVGDNANAAENTVLNYGNSPSLHAPNTSLNNSGSLAFPKLTINTGYPVTKLKFKPAYSSNIYNSLLGISSMGDEAEVRIYSLARKYIPKHVLLSETPSLGLVWWDENLIFNIDKGTRINGWDINKEPTVLENLSKNTTTWRDLDGNGLLSVDQEIGSYEVVEPELQPTSSTTCKKHPGTIKNPKNGNPENQGIIGGIKKGFSHTGLTSFTPERPPTLKAGPTFSTKSLTLASGASSFNSSSASLTSLTPQTENREEIAIEPPCIITLDIPQIFNNIRLTKIAHSRKKNVISESSSMKNSPVEKFKYLARQLKFSYIREHNVSDSADTAYKNDIENIDVVKNATETHGDNTTTTNNNDDGDDDDDDDDDDKIIESHLLKKYNFPENNTWATLMNEKVNNKKSKRNSSSSREFDEKDVRSSISSISASRQSHDRARKIDKNVEAELQEKIQTLVDLISIATHNASVYLSIDDLTNFKIWILIRDSLLWDLKWMTSSQISSDNASNMDANESSDFEAGENLKTGKEFPEEDGAGTSGAESLVEERPQAFRANSDEPSDAEKKPVSKLKEQLKNTEIIPYAQPNEDSDEVLTKLKELQNQRLESRTKMGETVSDDVIIEEDEHEHQEEEQPHDSPTKSAQFHASPIAKSIPILQKREHRKSFIDTFMLHSPNGYNGDTDIGNEDDNISPRFTYNSVSPRSKVSSLQSYATTTSQLETFKKLSSHTAPIIGSPRHAPSRPDSIGREQLSSSLTKKLAKCKKIIADPPWDTKKLIKQLYNQATETGNVVLTVNILFLFQTIYQITEIDIAKDAIAHFLLLLHRYELFGIAADVLKYCPFEDIMGSEGDQSSIRLFCERCGELITNESSKEKLRAEAQQTGNKKIMDKFGYWYCDSCKKKNTSCVLCERPLKKLTMVILPCGHEGHFQCIQEWFLDENEQECPGGCPGVAFI
SIO_010081: YOL138C
subclass of: SO_0000673
so part of: YOL138C
location: complement(61325..65350)
location: region:61325-65350:-1
so has part: feature:61325-65350:-1:exon

NP_014503.2
type: Protein
SIO_000068: ncbiprotein

S000005498
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:61325-65350:-1:exon

YOL137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BSC6
locus tag: YOL137W
so part of: sequence
location: <65621..>67114
location: region:65621-67114:1
so has part: feature:65621-67114:1:exon
subclass of: SO_0000010

853983
type: Gene
SIO_000068: ncbigene

position:65621:1
position: 65621
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:67114:1
position: 67114
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:65621-67114:1:exon

YOL137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BSC6
locus tag: YOL137W
product: Bsc6p
transcript id: NM_001183391.1
SIO_010081: YOL137W
subclass of: SO_0000673
so part of: YOL137W
location: <65621..>67114
location: region:65621-67114:1
so has part: feature:65621-67114:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:65621-67114:1:exon

YOL137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BSC6
locus tag: YOL137W
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
note: hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
codon start: 1
product: Bsc6p
translation: MDASSVPPKVDDYGMYTTEISHHNPIELKNLLSSSDSRRNSQDEDSLPNNTNLIKEIDWQGEKVKTYPLNYQTVPLVKLQVIACLIMFVVFGMNDQTVGALLPTLIEYYHISRVDVSNVFIVQLCGYVMASLSKERLNKHFGMRGGMLLAAGLCIVFLIILATAPSSFYVCMFCGLPLGLGIGILDSTGNVLMGSLLVHKNELMGIMHGLYGAAAMVTPPLVSYFVEWGHWSLFFLIPLFFSIIGMIVIFPAFKFETASKYDYLCSVENKESNNDVEEAGDNSLMESTKASPGFFELLRNPAIFLYSLYLFLYLGAEITTGSWFFSYLLETKSSNKVAMSYIAASFWTGLTVGRLCLGFVTERFFENEYKASKAYAFLTLSSYTLFVLVGLINSSSVFYFVVLFFVVFCCGTFIGPLFPNASIVALQVLPKRLHVSGVGVAVAVGGCGGAAIPYLAGVIAHTVGIQYIPLLCWIMVALFTLEWTLYPKFIKGHEEYF
SIO_010081: YOL137W
subclass of: SO_0000673
so part of: YOL137W
location: 65621..67114
location: region:65621-67114:1
so has part: feature:65621-67114:1:exon

NP_014504.1
type: Protein
SIO_000068: ncbiprotein

S000005497
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:65621-67114:1:exon

YOL136C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PFK27
locus tag: YOL136C
so part of: sequence
location: complement(<67561..>68754)
location: region:67561-68754:-1
so has part: feature:67561-68754:-1:exon
subclass of: SO_0000010

853984
type: Gene
SIO_000068: ncbigene

position:67561:-1
position: 67561
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:68754:-1
position: 68754
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67561-68754:-1:exon

YOL136C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PFK27
locus tag: YOL136C
product: 6-phosphofructo-2-kinase
transcript id: NM_001183390.1
SIO_010081: YOL136C
subclass of: SO_0000673
so part of: YOL136C
location: complement(<67561..>68754)
location: region:67561-68754:-1
so has part: feature:67561-68754:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:67561-68754:-1:exon

YOL136C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PFK27
locus tag: YOL136C
EC number: 2.7.1.105
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8861205]
experiment: EXISTENCE:mutant phenotype:GO:0006003 fructose 2,6-bisphosphate metabolic process [PMID:8861205]
experiment: EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:8861205]
note: 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
codon start: 1
product: 6-phosphofructo-2-kinase
translation: MGGSSDSDSHDGYLTSEYNSSNSLFSLNTGNSYSSASLDRATLDCQDSVFFDNHKSSLLSTEVPRFISNDPLHLPITLNYKRDNADPTYTNGKVNKFMIVLIGLPATGKSTISSHLIQCLKNNPLTNSLRCKVFNAGKIRRQISCATISKPLLLSNTSSEDLFNPKNNDKKETYARITLQKLFHEINNDECDVGIFDATNSTIERRRFIFEEVCSFNTDELSSFNLVPIILQVSCFNRSFIKYNIHNKSFNEDYLDKPYELAIKDFAKRLKHYYSQFTPFSLDEFNQIHRYISQHEEIDTSLFFFNVINAGVVEPHSLNQSHYPSTCGKQIRDTIMVIENFINHYSQMFGFEYIEAVKLFFESFGNSSEETLTTLDSVVNDKFFDDLQSLIESNGFA
SIO_010081: YOL136C
subclass of: SO_0000673
so part of: YOL136C
location: complement(67561..68754)
location: region:67561-68754:-1
so has part: feature:67561-68754:-1:exon

NP_014505.1
type: Protein
SIO_000068: ncbiprotein

S000005496
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67561-68754:-1:exon

YOL135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MED7
locus tag: YOL135C
so part of: sequence
location: complement(<69376..>70044)
location: region:69376-70044:-1
so has part: feature:69376-70044:-1:exon
subclass of: SO_0000010

853985
type: Gene
SIO_000068: ncbigene

position:69376:-1
position: 69376
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70044:-1
position: 70044
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:69376-70044:-1:exon

YOL135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MED7
locus tag: YOL135C
product: mediator complex subunit MED7
transcript id: NM_001183389.1
SIO_010081: YOL135C
subclass of: SO_0000673
so part of: YOL135C
location: complement(<69376..>70044)
location: region:69376-70044:-1
so has part: feature:69376-70044:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:69376-70044:-1:exon

YOL135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MED7
locus tag: YOL135C
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19057509]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16452140]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
codon start: 1
product: mediator complex subunit MED7
translation: MSNDPGNEVSSLYPPPPPYVKFFTQSNLEKLPKYKEKKAASAKQTAPNNSNGGSEEEITCALDYLIPPPMPKNQQYRAFGSIWQVKDQLPDLESMGLTQLYKKSTENESTNYQYKIQELRKLLKSLLLNYLELIGVLSINPDMYERKVENIRTILVNIHHLLNEYRPHQSRESLIMLLEEQLEYKRGEIREIEQVCKQVHDKLTSIQDTLRTGSQSPPSSSQ
SIO_010081: YOL135C
subclass of: SO_0000673
so part of: YOL135C
location: complement(69376..70044)
location: region:69376-70044:-1
so has part: feature:69376-70044:-1:exon

NP_014506.1
type: Protein
SIO_000068: ncbiprotein

S000005495
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:69376-70044:-1:exon

YOL133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRT2
alternative label: RBX1
alternative label: ROC1
gene: HRT1
locus tag: YOL133W
gene synonym: HRT2; RBX1; ROC1
so part of: sequence
location: <70325..>70690
location: region:70325-70690:1
so has part: feature:70325-70690:1:exon
subclass of: SO_0000010

853986
type: Gene
SIO_000068: ncbigene

position:70325:1
position: 70325
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70690:1
position: 70690
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70325-70690:1:exon

YOL133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRT2
alternative label: RBX1
alternative label: ROC1
gene: HRT1
locus tag: YOL133W
gene synonym: HRT2; RBX1; ROC1
product: SCF ubiquitin ligase complex subunit HRT1
transcript id: NM_001183387.1
SIO_010081: YOL133W
subclass of: SO_0000673
so part of: YOL133W
location: <70325..>70690
location: region:70325-70690:1
so has part: feature:70325-70690:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70325-70690:1:exon

YOL133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRT2
alternative label: RBX1
alternative label: ROC1
gene: HRT1
locus tag: YOL133W
gene synonym: HRT2; RBX1; ROC1
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10385629]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10385629]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:10385629|PMID:19882662]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:10213692]
experiment: EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10385629]
experiment: EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:12676951]
experiment: EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:12676951]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10230407]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10385629]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:10385629]
note: RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair
codon start: 1
product: SCF ubiquitin ligase complex subunit HRT1
translation: MSNEVDRMDVDEDESQNIAQSSNQSAPVETKKKRFEIKKWTAVAFWSWDIAVDNCAICRNHIMEPCIECQPKAMTDTDNECVAAWGVCNHAFHLHCINKWIKTRDACPLDNQPWQLARCGR
SIO_010081: YOL133W
subclass of: SO_0000673
so part of: YOL133W
location: 70325..70690
location: region:70325-70690:1
so has part: feature:70325-70690:1:exon

NP_014508.1
type: Protein
SIO_000068: ncbiprotein

S000005493
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70325-70690:1:exon

YOL132W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAS4
locus tag: YOL132W
so part of: sequence
location: <71300..>72715
location: region:71300-72715:1
so has part: feature:71300-72715:1:exon
subclass of: SO_0000010

853988
type: Gene
SIO_000068: ncbigene

position:71300:1
position: 71300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:72715:1
position: 72715
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:71300-72715:1:exon

YOL132W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAS4
locus tag: YOL132W
product: 1,3-beta-glucanosyltransferase
transcript id: NM_001183386.1
SIO_010081: YOL132W
subclass of: SO_0000673
so part of: YOL132W
location: <71300..>72715
location: region:71300-72715:1
so has part: feature:71300-72715:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:71300-72715:1:exon

YOL132W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAS4
locus tag: YOL132W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106]
experiment: EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:17189486]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17189486]
note: 1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
codon start: 1
product: 1,3-beta-glucanosyltransferase
translation: MMVFSSTFIFLILELVVLCEASVHTIQIKDKHFVDTVTGKPFFIKGVDYQPGGSSDVSEKQDPLSNPDACARDILLFQELGINTVRIYSINPDLNHDACMTMLAMAGIYLILDVNSPLQNQHLNRYEPWTTYNEVYLEHVFKVVEQFSHYNNTLGFFAGNEIVNDKRSAQYSPAYVKELIGTMKNYISAHSPRTIPVGYSAADDLNYRVSLSEYLECKDDDKPENSVDFYGVNSYQWCGQQTMQTSGYDTLVDAYRSYSKPVFFSEFGCNKVLPRQFQEIGYLFSEEMYSVFCGGLVYEFSQEDNNYGLVEYQEDDSVQLLADFEKLKSHYQNIEFPSMKTLKETVQMEETPSCAEDYENLKIESKIAKNLGSSLIKKGVKVEKGKYIDIHEDQLSTNVTILDKHGDRWNGPKKIEIRQSLTLADLEGEEQEDADEDKDDLKRKHRNSASISGPLLPLGLCLLFFTFSLFF
SIO_010081: YOL132W
subclass of: SO_0000673
so part of: YOL132W
location: 71300..72715
location: region:71300-72715:1
so has part: feature:71300-72715:1:exon

NP_014509.1
type: Protein
SIO_000068: ncbiprotein

S000005492
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:71300-72715:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1507; Autonomously Replicating Sequence
so part of: sequence
location: 72683..72753
location: region:72683-72753:1
so has part: feature:72683-72753:1:region

S000118484
type: SGD
SIO_000068: sgd

position:72683:1
position: 72683
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:72753:1
position: 72753
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:72683-72753:1:region

YOL131W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL131W
so part of: sequence
location: <73031..>73357
location: region:73031-73357:1
so has part: feature:73031-73357:1:exon
subclass of: SO_0000010

853989
type: Gene
SIO_000068: ncbigene

position:73031:1
position: 73031
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73357:1
position: 73357
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:73031-73357:1:exon

YOL131W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL131W
product: uncharacterized protein
transcript id: NM_001183385.1
SIO_010081: YOL131W
subclass of: SO_0000673
so part of: YOL131W
location: <73031..>73357
location: region:73031-73357:1
so has part: feature:73031-73357:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:73031-73357:1:exon

YOL131W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL131W
note: hypothetical protein; YOL131W has a paralog, STB1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MNTNKIAQDEVQDKVLQRAELAHSVWNLRFNLSKVAKRIRMETKVFPEIKINDAQSQLERSRCRIFSPDLEEEHVPLIQGFKCLDSPPPVPPSSSQGEDEENTVDSQY
SIO_010081: YOL131W
subclass of: SO_0000673
so part of: YOL131W
location: 73031..73357
location: region:73031-73357:1
so has part: feature:73031-73357:1:exon

NP_014510.1
type: Protein
SIO_000068: ncbiprotein

S000005491
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73031-73357:1:exon

YOL130W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SWC3
gene: ALR1
locus tag: YOL130W
gene synonym: SWC3
so part of: sequence
location: <74400..>76979
location: region:74400-76979:1
so has part: feature:74400-76979:1:exon
subclass of: SO_0000010

853990
type: Gene
SIO_000068: ncbigene

position:74400:1
position: 74400
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:76979:1
position: 76979
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74400-76979:1:exon

YOL130W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SWC3
gene: ALR1
locus tag: YOL130W
gene synonym: SWC3
product: Mg(2+) transporter ALR1
transcript id: NM_001183384.1
SIO_010081: YOL130W
subclass of: SO_0000673
so part of: YOL130W
location: <74400..>76979
location: region:74400-76979:1
so has part: feature:74400-76979:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74400-76979:1:exon

YOL130W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SWC3
gene: ALR1
locus tag: YOL130W
gene synonym: SWC3
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21738593]
experiment: EXISTENCE:direct assay:GO:0015693 magnesium ion transport [PMID:12167543]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9430719]
experiment: EXISTENCE:mutant phenotype:GO:0006812 cation transport [PMID:9430719]
experiment: EXISTENCE:mutant phenotype:GO:0022890 inorganic cation transmembrane transporter activity [PMID:9430719]
note: Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1
codon start: 1
product: Mg(2+) transporter ALR1
translation: MSSSSSSSESSPNLSRSNSLANTMVSMKTEDHTGLYDHRQHPDSLPVRHQPPTLKNKEIAKSTKPSIPKEQKSATRYNSHVDVGSVPSRGRMDFEDEGQGMDETVAHHQLRASAILTSNARPSRLAHSMPHQRQLYVESNIHTPPKDVGVKRDYTMSSSTASSGNKSKLSASSSASPITKVRKSSLVSPVLEIPHESKSDTHSKLAKPKKRTYSTTSAHSSINPAVLLTKSTSQKSDADDDTLERKPVRMNTRASFDSDVSQASRDSQETEEDVCFPMPPQLHTRVNGIDFDELEEYAQFANAEKSQFLASLQVPNEQKYSNVSQDIGFTSSTSTSGSSAALKYTPRVSQTGEKSESTNETEIHEKKEDEHEKIKPSLHPGISFGKNKVEGEENENIPSNDPAYCSYQGTDFQIPNRFSFFCSESDETVHASDIPSLVSEGQTFYELFRGGEPTWWLDCSCPTDDEMRCIAKAFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFENDKESEDFLEPINVYIVVCRSGVLTFHFGPISHCANVRRRVRQLRDYVNVNSDWLCYALIDDITDSFAPVIQSIEYEADAIEDSVFMARDMDFAAMLQRIGESRRKTMTLMRLLSGKADVIKMFAKRCQDEANGIGPALTSQINIANLQARQDNASHIKNNSSTTVPNNYAPTTSQPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHTNYLAQLQVESFNSNNKVTEMLGKVTMIGTMLVPLNVITGLFGMNVKVPGENSSIAWWFGILGVLLLLAVLGWFLASYWIKRIDPPATLNEAAESGAKSVISSFLPKRNKRFNDRSKNINVRAGPSNKSVASLPSRYSRYD
SIO_010081: YOL130W
subclass of: SO_0000673
so part of: YOL130W
location: 74400..76979
location: region:74400-76979:1
so has part: feature:74400-76979:1:exon

NP_014511.1
type: Protein
SIO_000068: ncbiprotein

S000005490
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74400-76979:1:exon

YOL129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VPS68
locus tag: YOL129W
so part of: sequence
location: <77560..>78114
location: region:77560-78114:1
so has part: feature:77560-78114:1:exon
subclass of: SO_0000010

853991
type: Gene
SIO_000068: ncbigene

position:77560:1
position: 77560
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:78114:1
position: 78114
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77560-78114:1:exon

YOL129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VPS68
locus tag: YOL129W
product: Vps68p
transcript id: NM_001183383.1
SIO_010081: YOL129W
subclass of: SO_0000673
so part of: YOL129W
location: <77560..>78114
location: region:77560-78114:1
so has part: feature:77560-78114:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77560-78114:1:exon

YOL129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VPS68
locus tag: YOL129W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23708375|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0034424 Vps55/Vps68 complex [PMID:18216282]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18216282]
experiment: EXISTENCE:physical interaction:GO:0034424 Vps55/Vps68 complex [PMID:18216282]
note: Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria
codon start: 1
product: Vps68p
translation: MEADDHVSLFRFPFKIPTFRGIRKGGVYLSGALYALGFWIFLDAVLYSRYSNASDVHVTFIDWIPFLCSTLGTLIVNSIEKNRLLQGALSSDGGAFGSGVGDLDSSMAWQARTVLFFGFALLAGGLSGSIVVLIIKFLVKDYNTYPTLGMGVNNVLGNVCILLSCVVLWIAQNVEDEYSYSLTL
SIO_010081: YOL129W
subclass of: SO_0000673
so part of: YOL129W
location: 77560..78114
location: region:77560-78114:1
so has part: feature:77560-78114:1:exon

NP_014512.1
type: Protein
SIO_000068: ncbiprotein

S000005489
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77560-78114:1:exon

YOL128C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YGK3
locus tag: YOL128C
so part of: sequence
location: complement(<78352..>79479)
location: region:78352-79479:-1
so has part: feature:78352-79479:-1:exon
subclass of: SO_0000010

853992
type: Gene
SIO_000068: ncbigene

position:78352:-1
position: 78352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79479:-1
position: 79479
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78352-79479:-1:exon

YOL128C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YGK3
locus tag: YOL128C
product: serine/threonine protein kinase YGK3
transcript id: NM_001183382.1
SIO_010081: YOL128C
subclass of: SO_0000673
so part of: YOL128C
location: complement(<78352..>79479)
location: region:78352-79479:-1
so has part: feature:78352-79479:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78352-79479:-1:exon

YOL128C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YGK3
locus tag: YOL128C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10958669]
experiment: EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:10958669]
note: Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase YGK3
translation: MLKVNNVFGSNPNRMTKLEDEHYFIDDIVSIKNRQKSKMYVREGKRIGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMHWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASEKRALGEYYNLIVPSLD
SIO_010081: YOL128C
subclass of: SO_0000673
so part of: YOL128C
location: complement(78352..79479)
location: region:78352-79479:-1
so has part: feature:78352-79479:-1:exon

NP_014513.1
type: Protein
SIO_000068: ncbiprotein

S000005488
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78352-79479:-1:exon

YOL127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL25
locus tag: YOL127W
so part of: sequence
location: <80348..>81190
location: region:80348-81190:1
so has part: feature:80348-81190:1:exon
subclass of: SO_0000010

853993
type: Gene
SIO_000068: ncbigene

position:80348:1
position: 80348
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:81190:1
position: 81190
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80348-81190:1:exon

YOL127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL25
locus tag: YOL127W
product: ribosomal 60S subunit protein L25
transcript id: NM_001183381.1
SIO_010081: YOL127W
subclass of: SO_0000673
so part of: YOL127W
location: join(<80348..80360,80775..>81190)
location: region:80348-81190:1
so has part: feature:80348-80360:1:exon
so has part: feature:80775-81190:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80348-80360:1:exon

position:80360:1
position: 80360
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:80775-81190:1:exon

position:80775:1
position: 80775
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOL127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL25
locus tag: YOL127W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8028007]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:8028007]
note: Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
codon start: 1
product: ribosomal 60S subunit protein L25
translation: MAPSAKATAAKKAVVKGTNGKKALKVRTSATFRLPKTLKLARAPKYASKAVPHYNRLDSYKVIEQPITSETAMKKVEDGNILVFQVSMKANKYQIKKAVKELYEVDVLKVNTLVRPNGTKKAYVRLTADYDALDIANRIGYI
SIO_010081: YOL127W
subclass of: SO_0000673
so part of: YOL127W
location: join(80348..80360,80775..81190)
location: region:80348-81190:1
so has part: feature:80348-80360:1:exon
so has part: feature:80775-81190:1:exon

NP_014514.1
type: Protein
SIO_000068: ncbiprotein

S000005487
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80348-80360:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:80775-81190:1:exon

YOL126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDH2
locus tag: YOL126C
so part of: sequence
location: complement(<81787..>82920)
location: region:81787-82920:-1
so has part: feature:81787-82920:-1:exon
subclass of: SO_0000010

853994
type: Gene
SIO_000068: ncbigene

position:81787:-1
position: 81787
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82920:-1
position: 82920
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81787-82920:-1:exon

YOL126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDH2
locus tag: YOL126C
product: malate dehydrogenase MDH2
transcript id: NM_001183380.1
SIO_010081: YOL126C
subclass of: SO_0000673
so part of: YOL126C
location: complement(<81787..>82920)
location: region:81787-82920:-1
so has part: feature:81787-82920:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81787-82920:-1:exon

YOL126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDH2
locus tag: YOL126C
EC number: 1.1.1.37
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1986231]
experiment: EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase activity [PMID:1986231]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:12730240]
experiment: EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:19118449]
experiment: EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase activity [PMID:1986231]
note: Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy
codon start: 1
product: malate dehydrogenase MDH2
translation: MPHSVTPSIEQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHIDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEFVASRSASS
SIO_010081: YOL126C
subclass of: SO_0000673
so part of: YOL126C
location: complement(81787..82920)
location: region:81787-82920:-1
so has part: feature:81787-82920:-1:exon

NP_014515.2
type: Protein
SIO_000068: ncbiprotein

S000005486
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81787-82920:-1:exon

YOL125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM13
locus tag: YOL125W
so part of: sequence
location: <83834..>85264
location: region:83834-85264:1
so has part: feature:83834-85264:1:exon
subclass of: SO_0000010

853995
type: Gene
SIO_000068: ncbigene

position:83834:1
position: 83834
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85264:1
position: 85264
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:83834-85264:1:exon

YOL125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM13
locus tag: YOL125W
product: tRNA:m4X modification enzyme
transcript id: NM_001183379.2
SIO_010081: YOL125W
subclass of: SO_0000673
so part of: YOL125W
location: <83834..>85264
location: region:83834-85264:1
so has part: feature:83834-85264:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:83834-85264:1:exon

YOL125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM13
locus tag: YOL125W
EC number: 2.1.1.225
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:17242307]
experiment: EXISTENCE:direct assay:GO:0106050 tRNA 2'-O-methyltransferase activity [PMID:17242307]
experiment: EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]
experiment: EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:17242307]
experiment: EXISTENCE:mutant phenotype:GO:0106050 tRNA 2'-O-methyltransferase activity [PMID:17242307]
note: 2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
codon start: 1
product: tRNA:m4X modification enzyme
translation: MLQDNNGPAVKRAKPSERLQCEYFMEKKKRRCGMTRSSQNLYCSEHLNLMKKAANSQVHNKNGSEAEKERERVPCPLDPNHTVWADQLKKHLKKCNKTKLSHLNDDKPYYEPGYNGENGLLSSSVKIDITAEHLVQSIELLYKVFEGESMDELPLRQLNNKLMSLKRFPQLPSNTKHAVQQSSLIENLVDAGAFERPESLNFIEFGCGRAEFSRYVSLYLLTQLTSLPAEHSGSNSNEFVLIDRATNRMKFDKKIKDDFSEIKSNSPSKPISCPSIKRIKIDIRDLKMDPILKSTPGDDIQYVCISKHLCGVATDLTLRCIGNSSILHGDDNNGCNPKLKAICIAMCCRHVCDYGDYVNRSYVTSLVEKYRAHGSILTYETFFRVLTKLCSWGTCGRKPGTAITDIVNVVESFEGAEPYTITIKERENIGLMARRVIDEGRLVYVKEKFTEFNAELIRYVESDVSLENVAMLVYKK
SIO_010081: YOL125W
subclass of: SO_0000673
so part of: YOL125W
location: 83834..85264
location: region:83834-85264:1
so has part: feature:83834-85264:1:exon

NP_014516.1
type: Protein
SIO_000068: ncbiprotein

S000005485
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:83834-85264:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1508; Autonomously Replicating Sequence
so part of: sequence
location: 85270..85361
location: region:85270-85361:1
so has part: feature:85270-85361:1:region

S000118485
type: SGD
SIO_000068: sgd

position:85270:1
position: 85270
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:85361:1
position: 85361
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85270-85361:1:region

YOL124C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM11
locus tag: YOL124C
so part of: sequence
location: complement(<85456..>86757)
location: region:85456-86757:-1
so has part: feature:85456-86757:-1:exon
subclass of: SO_0000010

853996
type: Gene
SIO_000068: ncbigene

position:85456:-1
position: 85456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:86757:-1
position: 86757
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85456-86757:-1:exon

YOL124C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM11
locus tag: YOL124C
product: tRNA (guanine-N2-)-methyltransferase
transcript id: NM_001183378.1
SIO_010081: YOL124C
subclass of: SO_0000673
so part of: YOL124C
location: complement(<85456..>86757)
location: region:85456-86757:-1
so has part: feature:85456-86757:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85456-86757:-1:exon

YOL124C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM11
locus tag: YOL124C
EC number: 2.1.1.214
experiment: EXISTENCE:direct assay:GO:0004809 tRNA (guanine-N2-)-methyltransferase activity [PMID:15899842]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15899842|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:15899842]
experiment: EXISTENCE:mutant phenotype:GO:0004809 tRNA (guanine-N2-)-methyltransferase activity [PMID:15899842]
experiment: EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:15899842]
experiment: EXISTENCE:physical interaction:GO:0043528 tRNA (m2G10) methyltransferase complex [PMID:15899842]
note: Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p
codon start: 1
product: tRNA (guanine-N2-)-methyltransferase
translation: MKKYLLYMVQVHLNFRRAELESLADLYNLSIDFSQYDANSPFFIVELENDQQAKDWIKRSILTRGIYEYWGQGTTLDELHKDIQRQSNFEQDLQLKFKHSTFKFEFECYKGNSKAKRVEQIETFRYLGFEGKIDMKHPQEVFTVIEEYTPISENVGGKTPTRIYFGRQVQMSNRSAMEKYDLKKRPYKGTTSFEAELSLVSANIAQVKPGTIMYDPFAGTGSFLVAGGHFGSLVIGSDIDGRMIRGKGAQVNISANFKKYGESSQFLDVLTMDFTNNALRNNLVIDTILCDPPYGIRESIKVLGAKDPERFLGKEDMEIDGEKAYLRRDYIPTKKPYALDSLLDDLLQYSSERLPIGGRLAFWMPTANDANIETIVPMHENLELKYNCVQEFNKWSRRLLVYINRGSTFNGSSNHGIKRSKDNFRERYFNNFN
SIO_010081: YOL124C
subclass of: SO_0000673
so part of: YOL124C
location: complement(85456..86757)
location: region:85456-86757:-1
so has part: feature:85456-86757:-1:exon

NP_014517.1
type: Protein
SIO_000068: ncbiprotein

S000005484
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85456-86757:-1:exon

YOL123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAB4
alternative label: NAB5
gene: HRP1
locus tag: YOL123W
gene synonym: NAB4; NAB5
so part of: sequence
location: <87844..>89448
location: region:87844-89448:1
so has part: feature:87844-89448:1:exon
subclass of: SO_0000010

853997
type: Gene
SIO_000068: ncbigene

position:87844:1
position: 87844
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:89448:1
position: 89448
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87844-89448:1:exon

YOL123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAB4
alternative label: NAB5
gene: HRP1
locus tag: YOL123W
gene synonym: NAB4; NAB5
product: Hrp1p
transcript id: NM_001183377.1
SIO_010081: YOL123W
subclass of: SO_0000673
so part of: YOL123W
location: <87844..>89448
location: region:87844-89448:1
so has part: feature:87844-89448:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87844-89448:1:exon

YOL123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAB4
alternative label: NAB5
gene: HRP1
locus tag: YOL123W
gene synonym: NAB4; NAB5
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9334319]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:15703440|PMID:23222640|PMID:17684230]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9334319|PMID:15572678|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9334319]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11344258]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11344258]
experiment: EXISTENCE:mutant phenotype:GO:0006378 mRNA polyadenylation [PMID:9334319]
experiment: EXISTENCE:mutant phenotype:GO:0072423 response to DNA damage checkpoint signaling [PMID:24603480]
experiment: EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]
note: Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis
codon start: 1
product: Hrp1p
translation: MSSDEEDFNDIYGDDKPTTTEEVKKEEEQNKAGSGTSQLDQLAALQALSSSLNKLNNPNSNNSSSNNSNQDTSSSKQDGTANDKEGSNEDTKNEKKQESATSANANANASSAGPSGLPWEQLQQTMSQFQQPSSQSPPQQQVTQTKEERSKADLSKESCKMFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKDPATGRSRGFGFLSFEKPSSVDEVVKTQHILDGKVIDPKRAIPRDEQDKTGKIFVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRAEPRHMQQKSSNNGGNNGGNNMNRRGGNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQQMQKQTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQTIGNTSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYGYNRDRGDRDRNDRDRDYNHRSGGNHRRNGRGGRGGYNRRNNGYHPYNR
SIO_010081: YOL123W
subclass of: SO_0000673
so part of: YOL123W
location: 87844..89448
location: region:87844-89448:1
so has part: feature:87844-89448:1:exon

NP_014518.1
type: Protein
SIO_000068: ncbiprotein

S000005483
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87844-89448:1:exon

YOL122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SBS1
gene: SMF1
locus tag: YOL122C
gene synonym: SBS1
so part of: sequence
location: complement(<89692..>91419)
location: region:89692-91419:-1
so has part: feature:89692-91419:-1:exon
subclass of: SO_0000010

854027
type: Gene
SIO_000068: ncbigene

position:89692:-1
position: 89692
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:91419:-1
position: 91419
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:89692-91419:-1:exon

YOL122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SBS1
gene: SMF1
locus tag: YOL122C
gene synonym: SBS1
product: divalent metal ion transporter SMF1
transcript id: NM_001183376.1
SIO_010081: YOL122C
subclass of: SO_0000673
so part of: YOL122C
location: complement(<89692..>91419)
location: region:89692-91419:-1
so has part: feature:89692-91419:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:89692-91419:-1:exon

YOL122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SBS1
gene: SMF1
locus tag: YOL122C
gene synonym: SBS1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8643535]
experiment: EXISTENCE:direct assay:GO:0015295 solute:proton symporter activity [PMID:10574989]
experiment: EXISTENCE:direct assay:GO:0022890 inorganic cation transmembrane transporter activity [PMID:10574989]
experiment: EXISTENCE:genetic interaction:GO:0006825 copper ion transport [PMID:9115231]
experiment: EXISTENCE:genetic interaction:GO:0006826 iron ion transport [PMID:10930410]
experiment: EXISTENCE:genetic interaction:GO:0006876 cellular cadmium ion homeostasis [PMID:9115231]
experiment: EXISTENCE:genetic interaction:GO:0006878 cellular copper ion homeostasis [PMID:9115231]
experiment: EXISTENCE:genetic interaction:GO:0015691 cadmium ion transport [PMID:9115231]
experiment: EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:8643535]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:8643535]
note: Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
codon start: 1
product: divalent metal ion transporter SMF1
translation: MVNVGPSHAAVAVDASEARKRNISEEVFELRDKKDSTVVIEGEAPVRTFTSSSSNHEREDTYVSKRQVMRDIFAKYLKFIGPGLMVSVAYIDPGNYSTAVDAGASNQFSLLCIILLSNFIAIFLQCLCIKLGSVTGLDLSRACREYLPRWLNWTLYFFAECAVIATDIAEVIGTAIALNILIKVPLPAGVAITVVDVFLIMFTYKPGASSIRFIRIFECFVAVLVVGVCICFAIELAYIPKSTSVKQVFRGFVPSAQMFDHNGIYTAISILGATVMPHSLFLGSALVQPRLLDYDVKHGNYTVSEEQDKVKKSKSTEEIMEEKYFNYRPTNAAIKYCMKYSMVELSITLFTLALFVNCAILVVAGSTLYNSPEADGADLFTIHELLSRNLAPAAGTIFMLALLLSGQSAGVVCTMSGQIVSEGHINWKLQPWQRRLATRCISIIPCLVISICIGREALSKALNASQVVLSIVLPFLVAPLIFFTCKKSIMKTEITVDHTEEDSHNHQNNNDRSAGSVIEQDGSSGMEIENGKDVKIVYMANNWIITVIAIIVWLFLSLLNVYAIVQLGMSHGDIS
SIO_010081: YOL122C
subclass of: SO_0000673
so part of: YOL122C
location: complement(89692..91419)
location: region:89692-91419:-1
so has part: feature:89692-91419:-1:exon

NP_014519.1
type: Protein
SIO_000068: ncbiprotein

S000005482
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:89692-91419:-1:exon

YOL121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS19A
locus tag: YOL121C
so part of: sequence
location: complement(<92026..>92850)
location: region:92026-92850:-1
so has part: feature:92026-92850:-1:exon
subclass of: SO_0000010

854028
type: Gene
SIO_000068: ncbigene

position:92026:-1
position: 92026
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:92850:-1
position: 92850
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92026-92850:-1:exon

YOL121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS19A
locus tag: YOL121C
product: ribosomal 40S subunit protein S19A
transcript id: NM_001183375.1
SIO_010081: YOL121C
subclass of: SO_0000673
so part of: YOL121C
location: complement(join(<92026..92440,92831..>92850))
location: region:92026-92850:-1
so has part: feature:92831-92850:-1:exon
so has part: feature:92026-92440:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92831-92850:-1:exon

position:92831:-1
position: 92831
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:92026-92440:-1:exon

position:92440:-1
position: 92440
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YOL121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS19A
locus tag: YOL121C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728|PMID:16159874]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:16159874]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]
note: Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S19A
translation: MPGVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNEMPPQDAEGWFYKRAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINRKVLQALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEEDE
SIO_010081: YOL121C
subclass of: SO_0000673
so part of: YOL121C
location: complement(join(92026..92440,92831..92850))
location: region:92026-92850:-1
so has part: feature:92831-92850:-1:exon
so has part: feature:92026-92440:-1:exon

NP_014520.1
type: Protein
SIO_000068: ncbiprotein

S000005481
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92831-92850:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:92026-92440:-1:exon

YOL120C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RP28A
gene: RPL18A
locus tag: YOL120C
gene synonym: RP28A
so part of: sequence
location: complement(<93395..>94402)
location: region:93395-94402:-1
so has part: feature:93395-94402:-1:exon
subclass of: SO_0000010

854029
type: Gene
SIO_000068: ncbigene

position:93395:-1
position: 93395
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:94402:-1
position: 94402
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:93395-94402:-1:exon

YOL120C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RP28A
gene: RPL18A
locus tag: YOL120C
gene synonym: RP28A
product: ribosomal 60S subunit protein L18A
transcript id: NM_001183374.1
SIO_010081: YOL120C
subclass of: SO_0000673
so part of: YOL120C
location: complement(join(<93395..93843,94291..>94402))
location: region:93395-94402:-1
so has part: feature:94291-94402:-1:exon
so has part: feature:93395-93843:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94291-94402:-1:exon

position:94291:-1
position: 94291
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:93395-93843:-1:exon

position:93843:-1
position: 93843
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YOL120C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RP28A
gene: RPL18A
locus tag: YOL120C
gene synonym: RP28A
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L18A
translation: MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV
SIO_010081: YOL120C
subclass of: SO_0000673
so part of: YOL120C
location: complement(join(93395..93843,94291..94402))
location: region:93395-94402:-1
so has part: feature:94291-94402:-1:exon
so has part: feature:93395-93843:-1:exon

NP_014521.1
type: Protein
SIO_000068: ncbiprotein

S000005480
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94291-94402:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:93395-93843:-1:exon

YOL119C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCH4
locus tag: YOL119C
so part of: sequence
location: complement(<94856..>96361)
location: region:94856-96361:-1
so has part: feature:94856-96361:-1:exon
subclass of: SO_0000010

854030
type: Gene
SIO_000068: ncbigene

position:94856:-1
position: 94856
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:96361:-1
position: 96361
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94856-96361:-1:exon

YOL119C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCH4
locus tag: YOL119C
product: Mch4p
transcript id: NM_001183373.1
SIO_010081: YOL119C
subclass of: SO_0000673
so part of: YOL119C
location: complement(<94856..>96361)
location: region:94856-96361:-1
so has part: feature:94856-96361:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94856-96361:-1:exon

YOL119C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCH4
locus tag: YOL119C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11536335]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport
codon start: 1
product: Mch4p
translation: MLNIPIIANSKRFLFSKDHEAQSTRDHDVELETREGPSSGYNPNFNAADAILKKNSDQVDLDVNKLTNVTSRVLNTPEASLIYDDDREFPDGGLKAWLVVFGAFMGLVPVFGLINSLGAIESYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIGKGTVANYNHFIIFNSALMAAGAACYIISRHICVGAKLCKF
SIO_010081: YOL119C
subclass of: SO_0000673
so part of: YOL119C
location: complement(94856..96361)
location: region:94856-96361:-1
so has part: feature:94856-96361:-1:exon

NP_014522.1
type: Protein
SIO_000068: ncbiprotein

S000005479
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94856-96361:-1:exon

YOL118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL118C
so part of: sequence
location: complement(<96608..>96916)
location: region:96608-96916:-1
so has part: feature:96608-96916:-1:exon
subclass of: SO_0000010

854031
type: Gene
SIO_000068: ncbigene

position:96608:-1
position: 96608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:96916:-1
position: 96916
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96608-96916:-1:exon

YOL118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL118C
product: uncharacterized protein
transcript id: NM_001348874.1
SIO_010081: YOL118C
subclass of: SO_0000673
so part of: YOL118C
location: complement(<96608..>96916)
location: region:96608-96916:-1
so has part: feature:96608-96916:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:96608-96916:-1:exon

YOL118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL118C
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MSFRKKKLKPPAGSQFIINDSIMSYIDRTKTLIRMIGCKNQYIKARMKDKTFFYTKQFRTAKNKFFFHLYHWEATHINVDHYICTCHPIFWGSIGQKLRRSA
SIO_010081: YOL118C
subclass of: SO_0000673
so part of: YOL118C
location: complement(96608..96916)
location: region:96608-96916:-1
so has part: feature:96608-96916:-1:exon

NP_001335812.1
type: Protein
SIO_000068: ncbiprotein

S000005478
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:96608-96916:-1:exon

YOL117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSN10
gene: RRI2
locus tag: YOL117W
gene synonym: CSN10
so part of: sequence
location: <97551..>99488
location: region:97551-99488:1
so has part: feature:97551-99488:1:exon
subclass of: SO_0000010

854032
type: Gene
SIO_000068: ncbigene

position:97551:1
position: 97551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99488:1
position: 99488
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97551-99488:1:exon

YOL117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSN10
gene: RRI2
locus tag: YOL117W
gene synonym: CSN10
product: Rri2p
transcript id: NM_001183371.1
SIO_010081: YOL117W
subclass of: SO_0000673
so part of: YOL117W
location: <97551..>99488
location: region:97551-99488:1
so has part: feature:97551-99488:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:97551-99488:1:exon

YOL117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSN10
gene: RRI2
locus tag: YOL117W
gene synonym: CSN10
experiment: EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]
experiment: EXISTENCE:genetic interaction:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:12446563]
experiment: EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12186635|PMID:12446563]
note: Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
codon start: 1
product: Rri2p
translation: MSDEDNNYDDFMLSDDEGMESIEMEEETDDEDKQNIEINEDNSQDDQDRGAARHKQHEQGTFEKHDRVEDICERIFEQGQALKEDERYKEARDLFLKIYYKEEFSSDESIERLMTWKFKSLIEILRLRALQLYFQKNGAQDLVLQILEDTATMSVFLQRIDFQIDGNIFELLSDTFEVLAPKWERVFLFDIEKVDRENMICKIDFQKNFMDQFQWILRKPGKDCKLQNLQRIIRKKIFIAVVWYQRLTMGNVFTPEISSQIEILVKDNECSSFEENNDLESVSMLLQYYILEYMNTARINNRRLFKKCIDFFEMLISKSLTFSQESGLMVILYTSKIVFILDSDSENDLSFALMRYYDRKEELKNMFLYILKHLEEMGKLRERDITSLFHKFILSGFIFTSMILEAISTDKINPFGFEQVKIALGSPIVNVLEDVYRCFAQLELRQLNASISLIPELSVVLSGIIQDIYYLAQTLKLWRKIARLYSCISISDIISMLQISDDNEMTRDDLLTILMRSIMKNRSVVYFKLDLTSDLVYFGDENKVMLPRCSKEEFRLMISPKDEETTEKARLIDFEYVNDVAIYNNPTRIRTKSSKEFFNTLRKSRETVKLPRVSNQSNEDTFLPSYMKFSNKYLELCKLASNNLE
SIO_010081: YOL117W
subclass of: SO_0000673
so part of: YOL117W
location: 97551..99488
location: region:97551-99488:1
so has part: feature:97551-99488:1:exon

NP_014524.1
type: Protein
SIO_000068: ncbiprotein

S000005477
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:97551-99488:1:exon

YOL116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FUP1
alternative label: HRB382
alternative label: MSS10
alternative label: PHD2
gene: MSN1
locus tag: YOL116W
gene synonym: FUP1; HRB382; MSS10; PHD2
so part of: sequence
location: <99809..>100957
location: region:99809-100957:1
so has part: feature:99809-100957:1:exon
subclass of: SO_0000010

854033
type: Gene
SIO_000068: ncbigene

position:99809:1
position: 99809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:100957:1
position: 100957
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99809-100957:1:exon

YOL116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FUP1
alternative label: HRB382
alternative label: MSS10
alternative label: PHD2
gene: MSN1
locus tag: YOL116W
gene synonym: FUP1; HRB382; MSS10; PHD2
product: Msn1p
transcript id: NM_001183370.1
SIO_010081: YOL116W
subclass of: SO_0000673
so part of: YOL116W
location: <99809..>100957
location: region:99809-100957:1
so has part: feature:99809-100957:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99809-100957:1:exon

YOL116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FUP1
alternative label: HRB382
alternative label: MSS10
alternative label: PHD2
gene: MSN1
locus tag: YOL116W
gene synonym: FUP1; HRB382; MSS10; PHD2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2263457|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10409737]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15773992|PMID:8710886|PMID:9987114|PMID:10409737|PMI D:8662191]
note: Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Msn1p
translation: MASNQHIGASNLNENEAILTNRVAELERRMSMFEGIFHALSNRLDLHFKKYDVVVNSQQQQINELTAFLSTLLNDQQRHAEILSEKLSGTLHGVSATSISLSQTLDPQGFTDGTTAPGAPRNYTSVPMNNDQTAHPQNEGAVSNETLFEDILNGNSQENDKSQQQTNSSNSISQENNSTNPSVDTRFNKPQNYNSNLVPSLEEYSANPPNNDGGQSQGLYISSNSSQSRQSPNLQKVSPNHENAVESNAQESVPTFEEEQYETKTGLKRKRIVCTRPFEFIKSPHSVMEVWKEYTEGVNGQPSIRKMEALYQTAWRRDPAVNKRYSRRKVLWKAIQTGLNRGYSLNYVVEILENSRYVNDKQKVKQPIGWLCHSSHIPETLK
SIO_010081: YOL116W
subclass of: SO_0000673
so part of: YOL116W
location: 99809..100957
location: region:99809-100957:1
so has part: feature:99809-100957:1:exon

NP_014525.1
type: Protein
SIO_000068: ncbiprotein

S000005476
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99809-100957:1:exon

YOL115W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TRF4
gene: PAP2
locus tag: YOL115W
gene synonym: TRF4
so part of: sequence
location: <101475..>103229
location: region:101475-103229:1
so has part: feature:101475-103229:1:exon
subclass of: SO_0000010

854034
type: Gene
SIO_000068: ncbigene

position:101475:1
position: 101475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:103229:1
position: 103229
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:101475-103229:1:exon

YOL115W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TRF4
gene: PAP2
locus tag: YOL115W
gene synonym: TRF4
product: non-canonical poly(A) polymerase PAP2
transcript id: NM_001183369.1
SIO_010081: YOL115W
subclass of: SO_0000673
so part of: YOL115W
location: <101475..>103229
location: region:101475-103229:1
so has part: feature:101475-103229:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:101475-103229:1:exon

YOL115W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TRF4
gene: PAP2
locus tag: YOL115W
gene synonym: TRF4
EC number: 2.7.7.19
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004652 polynucleotide adenylyltransferase activity [PMID:12062100|PMID:15935758|PMID:15935759|PMID:16260630|P MID:16374505]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10066793|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15828860|PMID:15935758|PMID:15935759]
experiment: EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:22532666]
experiment: EXISTENCE:direct assay:GO:0043629 ncRNA polyadenylation [PMID:15935758|PMID:15828860]
experiment: EXISTENCE:direct assay:GO:0051575 5'-deoxyribose-5-phosphate lyase activity [PMID:17983848]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:15935758|PMID:17643380]
experiment: EXISTENCE:genetic interaction:GO:0004652 polynucleotide adenylyltransferase activity [PMID:16374505]
experiment: EXISTENCE:genetic interaction:GO:0006284 base-excision repair [PMID:17983848]
experiment: EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0043629 ncRNA polyadenylation [PMID:15145828|PMID:15935759|PMID:16373491|PMID:16374505]
experiment: EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]
experiment: EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:16541108]
experiment: EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758|PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15145828]
experiment: EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]
experiment: EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0071044 histone mRNA catabolic process [PMID:17179095]
experiment: EXISTENCE:genetic interaction:GO:0071050 sno(s)RNA polyadenylation [PMID:18951092]
experiment: EXISTENCE:genetic interaction:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0004652 polynucleotide adenylyltransferase activity [PMID:15828860|PMID:15935759|PMID:16260630]
experiment: EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:17983848]
experiment: EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:22319136]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:25210768]
experiment: EXISTENCE:mutant phenotype:GO:0043629 ncRNA polyadenylation [PMID:15828860|PMID:16431988]
experiment: EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:23762389]
experiment: EXISTENCE:mutant phenotype:GO:0051575 5'-deoxyribose-5-phosphate lyase activity [PMID:17983848]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:16431988|PMID:18007593]
experiment: EXISTENCE:mutant phenotype:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758]
experiment: EXISTENCE:mutant phenotype:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758|PMID:16431988]
experiment: EXISTENCE:mutant phenotype:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:16431988|PMID:18456844]
experiment: EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258|PMID:15935759|PMID:16973436|PMID:18007593]
experiment: EXISTENCE:mutant phenotype:GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process [PMID:18022365]
experiment: EXISTENCE:mutant phenotype:GO:0071047 polyadenylation-dependent mRNA catabolic process [PMID:19369424]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]
note: Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia
codon start: 1
product: non-canonical poly(A) polymerase PAP2
translation: MGAKSVTASSSKKIKNRHNGKVKKSKKIKKVRKPQKSISLNDENEVEILPSRNEQETNKLPKDHVTADGILVLEHKSDDDEGFDVYDGHFDNPTDIPSTTEESKTPSLAVHGDEKDLANNDDFISLSASSEDEQAEQEEEREKQELEIKKEKQKEILNTDYPWILNHDHSKQKEISDWLTFEIKDFVAYISPSREEIEIRNQTISTIREAVKQLWPDADLHVFGSYSTDLYLPGSDIDCVVTSELGGKESRNNLYSLASHLKKKNLATEVEVVAKARVPIIKFVEPHSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRELVLIVKQFLHARRLNNVHTGGLGGFSIICLVFSFLHMHPRIITNEIDPKDNLGVLLIEFFELYGKNFGYDDVALGSSDGYPVYFPKSTWSAIQPIKNPFSLAIQDPGDESNNISRGSFNIRDIKKAFAGAFDLLTNRCFELHSATFKDRLGKSILGNVIKYRGKARDFKDERGLVLNKAIIENENYHKKRSRIIHDEDFAEDTVTSTATATTTDDDYEITNPPAKKAKIEEKPESEPAKRNSGETYITVSSEDDDEDGYNPYTL
SIO_010081: YOL115W
subclass of: SO_0000673
so part of: YOL115W
location: 101475..103229
location: region:101475-103229:1
so has part: feature:101475-103229:1:exon

NP_014526.1
type: Protein
SIO_000068: ncbiprotein

S000005475
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:101475-103229:1:exon

YOL114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTH4
locus tag: YOL114C
so part of: sequence
location: complement(<103317..>103925)
location: region:103317-103925:-1
so has part: feature:103317-103925:-1:exon
subclass of: SO_0000010

854035
type: Gene
SIO_000068: ncbigene

position:103317:-1
position: 103317
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:103925:-1
position: 103925
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:103317-103925:-1:exon

YOL114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTH4
locus tag: YOL114C
product: Pth4p
transcript id: NM_001183368.1
SIO_010081: YOL114C
subclass of: SO_0000673
so part of: YOL114C
location: complement(<103317..>103925)
location: region:103317-103925:-1
so has part: feature:103317-103925:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:103317-103925:-1:exon

YOL114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTH4
locus tag: YOL114C
experiment: EXISTENCE:direct assay:GO:0004045 aminoacyl-tRNA hydrolase activity [PMID:33686140]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:25683707]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:33686140]
note: Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene
codon start: 1
product: Pth4p
translation: MTTLMGKFKLTGRSPLFVLQPMLHCKKQQFVEEAVRLISNKKIGKKSDFVQARNWVGALNVTGLPLNQFILRYDRASGPGGQNVNKVNSKCTLTLSGLSNCAWIPQEVRNILSSGRFRYYAKGSDSIVIQSDETRSRETNKLKCFEKLVQEIRQTCQFPNDTTAETSKKWNKIKEKANKERLLDKKVHSDKKKNRSKIKFNY
SIO_010081: YOL114C
subclass of: SO_0000673
so part of: YOL114C
location: complement(103317..103925)
location: region:103317-103925:-1
so has part: feature:103317-103925:-1:exon

NP_014527.1
type: Protein
SIO_000068: ncbiprotein

S000005474
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:103317-103925:-1:exon

YOL113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKM1
locus tag: YOL113W
so part of: sequence
location: <104326..>106293
location: region:104326-106293:1
so has part: feature:104326-106293:1:exon
subclass of: SO_0000010

854036
type: Gene
SIO_000068: ncbigene

position:104326:1
position: 104326
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:106293:1
position: 106293
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:104326-106293:1:exon

YOL113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKM1
locus tag: YOL113W
product: putative serine/threonine protein kinase SKM1
transcript id: NM_001183367.1
SIO_010081: YOL113W
subclass of: SO_0000673
so part of: YOL113W
location: <104326..>106293
location: region:104326-106293:1
so has part: feature:104326-106293:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:104326-106293:1:exon

YOL113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKM1
locus tag: YOL113W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19793923]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15023338]
experiment: EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:9044278]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]
note: Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication
codon start: 1
product: putative serine/threonine protein kinase SKM1
translation: MKGVKKEGWISYKVDGLFSFLWQKRYLVLNDSYLAFYKSDKCNEEPVLSVPLTSITNVSRIQLKQNCFEILRATDQKENISPINSYFYESNSKRSIFISTRTERDLHGWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYNGLDTMQFNDHLNTSLDLKPLKSPTRYIINKRTNSIKRSVSRTLRKGKTDSILPVYQSELKPFPRPSDDDYKFTNIEDNKVREEGRVHVSKESTADSQTKQLGKKEQKVIQSHLRRHDNNSTFRPHRLAPSAPATKNHDSKTKWHKEDLLELKNNDDSNEIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVSLKWH
SIO_010081: YOL113W
subclass of: SO_0000673
so part of: YOL113W
location: 104326..106293
location: region:104326-106293:1
so has part: feature:104326-106293:1:exon

NP_014528.1
type: Protein
SIO_000068: ncbiprotein

S000005473
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:104326-106293:1:exon

YOL112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSB4
locus tag: YOL112W
so part of: sequence
location: <106710..>108188
location: region:106710-108188:1
so has part: feature:106710-108188:1:exon
subclass of: SO_0000010

854037
type: Gene
SIO_000068: ncbigene

position:106710:1
position: 106710
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108188:1
position: 108188
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:106710-108188:1:exon

YOL112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSB4
locus tag: YOL112W
product: Rab GTPase-activating protein MSB4
transcript id: NM_001183366.1
SIO_010081: YOL112W
subclass of: SO_0000673
so part of: YOL112W
location: <106710..>108188
location: region:106710-108188:1
so has part: feature:106710-108188:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:106710-108188:1:exon

YOL112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSB4
locus tag: YOL112W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10679030]
experiment: EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10937877]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10679030]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]
experiment: EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]
experiment: EXISTENCE:physical interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:12913108|PMID:16166638]
note: GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant
codon start: 1
product: Rab GTPase-activating protein MSB4
translation: MIMSSTMSTEAALVPNESVFDTVSSFNEDDANYSVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSLIMADPENFDRYGFSKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEEKAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVALGILKLSESEFLESKSQKLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEADMEILQVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQRASSRPKERRK
SIO_010081: YOL112W
subclass of: SO_0000673
so part of: YOL112W
location: 106710..108188
location: region:106710-108188:1
so has part: feature:106710-108188:1:exon

NP_014529.1
type: Protein
SIO_000068: ncbiprotein

S000005472
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:106710-108188:1:exon

YOL111C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GET5
alternative label: TMA24
gene: MDY2
locus tag: YOL111C
gene synonym: GET5; TMA24
so part of: sequence
location: complement(<108258..>108896)
location: region:108258-108896:-1
so has part: feature:108258-108896:-1:exon
subclass of: SO_0000010

854038
type: Gene
SIO_000068: ncbigene

position:108258:-1
position: 108258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108896:-1
position: 108896
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108258-108896:-1:exon

YOL111C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GET5
alternative label: TMA24
gene: MDY2
locus tag: YOL111C
gene synonym: GET5; TMA24
product: Mdy2p
transcript id: NM_001183365.1
SIO_010081: YOL111C
subclass of: SO_0000673
so part of: YOL111C
location: complement(<108258..>108896)
location: region:108258-108896:-1
so has part: feature:108258-108896:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108258-108896:-1:exon

YOL111C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GET5
alternative label: TMA24
gene: MDY2
locus tag: YOL111C
gene synonym: GET5; TMA24
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16390866|PMID:23285234]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23285234|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:17441508]
experiment: EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]
experiment: EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:19325107]
experiment: EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:16390866]
note: Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
codon start: 1
product: Mdy2p
translation: MSTSASGPEHEFVSKFLTLATLTEPKLPKSYTKPLKDVTNLGVPLPTLKYKYKQNRAKKLKLHQDQQGQDNAAVHLTLKKIQAPKFSIEHDFSPSDTILQIKQHLISEEKASHISEIKLLLKGKVLHDNLFLSDLKVTPANSTITVMIKPNPTISKEPEAEKSTNSPAPAPPQELTVPWDDIEALLKNNFENDQAAVRQVMERLQKGWSLAK
SIO_010081: YOL111C
subclass of: SO_0000673
so part of: YOL111C
location: complement(108258..108896)
location: region:108258-108896:-1
so has part: feature:108258-108896:-1:exon

NP_014530.1
type: Protein
SIO_000068: ncbiprotein

S000005471
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108258-108896:-1:exon

YOL110W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ERF4
gene: SHR5
locus tag: YOL110W
gene synonym: ERF4
so part of: sequence
location: <109176..>109889
location: region:109176-109889:1
so has part: feature:109176-109889:1:exon
subclass of: SO_0000010

854039
type: Gene
SIO_000068: ncbigene

position:109176:1
position: 109176
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:109889:1
position: 109889
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:109176-109889:1:exon

YOL110W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ERF4
gene: SHR5
locus tag: YOL110W
gene synonym: ERF4
product: Shr5p
transcript id: NM_001183364.1
SIO_010081: YOL110W
subclass of: SO_0000673
so part of: YOL110W
location: <109176..>109889
location: region:109176-109889:1
so has part: feature:109176-109889:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:109176-109889:1:exon

YOL110W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ERF4
gene: SHR5
locus tag: YOL110W
gene synonym: ERF4
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:12193598]
experiment: EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:12193598]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:7532279]
experiment: EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16751107]
experiment: EXISTENCE:physical interaction:GO:0031211 endoplasmic reticulum palmitoyltransferase complex [PMID:12193598]
note: Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2
codon start: 1
product: Shr5p
translation: MCDSHQKEEDNANTSERALFFNYHEFSYSFYEDLGSEDAKPTEHDEDHKLCITHFPNVYAARGSAEFQVTRVVRVPRRFDESRSSLETPQFSTQLPGSEPAAIVGDDGTSFVRCGRYDIGDHVFGCSSVSPLSEYLSAAELAEVVHRVNGFLLREEGEVFGWRNLSGLLLDMLTGGLWSWVLGPLLSRPVFQESLALEQYVAQLNSPGGLLHERGVRLVLPRRSGCLSLDFVVPRPK
SIO_010081: YOL110W
subclass of: SO_0000673
so part of: YOL110W
location: 109176..109889
location: region:109176-109889:1
so has part: feature:109176-109889:1:exon

NP_014531.1
type: Protein
SIO_000068: ncbiprotein

S000005470
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:109176-109889:1:exon

YOL109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZEO1
locus tag: YOL109W
so part of: sequence
location: <110297..>110638
location: region:110297-110638:1
so has part: feature:110297-110638:1:exon
subclass of: SO_0000010

854040
type: Gene
SIO_000068: ncbigene

position:110297:1
position: 110297
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110638:1
position: 110638
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110297-110638:1:exon

YOL109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZEO1
locus tag: YOL109W
product: Zeo1p
transcript id: NM_001183363.1
SIO_010081: YOL109W
subclass of: SO_0000673
so part of: YOL109W
location: <110297..>110638
location: region:110297-110638:1
so has part: feature:110297-110638:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:110297-110638:1:exon

YOL109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZEO1
locus tag: YOL109W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12949174|PMID:16622836]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12949174]
note: Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
codon start: 1
product: Zeo1p
translation: MSEIQNKAETAAQDVQQKLEETKESLQNKGQEVKEQAEASIDNLKNEATPEAEQVKKEEQNIADGVEQKKTEAANKVEETKKQASAAVSEKKETKKEGGFLKKLNRKIASIFN
SIO_010081: YOL109W
subclass of: SO_0000673
so part of: YOL109W
location: 110297..110638
location: region:110297-110638:1
so has part: feature:110297-110638:1:exon

NP_014532.1
type: Protein
SIO_000068: ncbiprotein

S000005469
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110297-110638:1:exon

YNCO0001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF1
locus tag: YNCO0001C
so part of: sequence
location: complement(110962..111033)
location: region:110962-111033:-1
so has part: feature:110962-111033:-1:exon
subclass of: SO_0000663

854041
type: Gene
SIO_000068: ncbigene

position:110962:-1
position: 110962
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:111033:-1
position: 111033
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110962-111033:-1:exon

YNCO0001C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF1
locus tag: YNCO0001C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons
SIO_010081: YNCO0001C
subclass of: SO_0000673
so part of: YNCO0001C
location: complement(110962..111033)
location: region:110962-111033:-1
so has part: feature:110962-111033:-1:exon

S000006592
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110962-111033:-1:exon

YOL108C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INO4
locus tag: YOL108C
so part of: sequence
location: complement(<111431..>111886)
location: region:111431-111886:-1
so has part: feature:111431-111886:-1:exon
subclass of: SO_0000010

854042
type: Gene
SIO_000068: ncbigene

position:111431:-1
position: 111431
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:111886:-1
position: 111886
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111431-111886:-1:exon

YOL108C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INO4
locus tag: YOL108C
product: Ino4p
transcript id: NM_001183362.1
SIO_010081: YOL108C
subclass of: SO_0000673
so part of: YOL108C
location: complement(<111431..>111886)
location: region:111431-111886:-1
so has part: feature:111431-111886:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111431-111886:-1:exon

YOL108C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INO4
locus tag: YOL108C
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8195172]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15455074]
experiment: EXISTENCE:direct assay:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:2834106]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1461729|PMID:8195172]
experiment: EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8195172]
experiment: EXISTENCE:physical interaction:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]
note: Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
codon start: 1
product: Ino4p
translation: MTNDIKEIQTIQPGLSEIKEIKGELANVKKRKRRSKKINKLTDGQIRINHVSSEKKRRELERAIFDELVAVVPDLQPQESRSELIIYLKSLSYLSWLYERNEKLRKQIIAKHEAKTGSSSSSDPVQEQNGNIRDLVPKELIWELGDGQSGQ
SIO_010081: YOL108C
subclass of: SO_0000673
so part of: YOL108C
location: complement(111431..111886)
location: region:111431-111886:-1
so has part: feature:111431-111886:-1:exon

NP_014533.1
type: Protein
SIO_000068: ncbiprotein

S000005468
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111431-111886:-1:exon

YOL107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL107W
so part of: sequence
location: <112102..>113130
location: region:112102-113130:1
so has part: feature:112102-113130:1:exon
subclass of: SO_0000010

854043
type: Gene
SIO_000068: ncbigene

position:112102:1
position: 112102
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:113130:1
position: 113130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112102-113130:1:exon

YOL107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL107W
product: uncharacterized protein
transcript id: NM_001183361.1
SIO_010081: YOL107W
subclass of: SO_0000673
so part of: YOL107W
location: <112102..>113130
location: region:112102-113130:1
so has part: feature:112102-113130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:112102-113130:1:exon

YOL107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL107W
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
codon start: 1
product: uncharacterized protein
translation: MQYSSRFLELNIPDSFLNINKIPDATKFITVTYICLTATLFCIRRSLYNKLVLEDPNLDYNLITSPLLQMVPSQIWRYPTSLVLSNFIDTKAWKVVVNLLNLIIGGSFIERNWNSSKEMFKFIIVLGSLTNVLIIMLTLLVSFFSNKVRLDIPLDGNYTILIGFPIIYRQLLPETTIIHLKTPQFLAKNFRFKLLPIFVMFTMTVTQIIWFHHFAQLFSIWVTFFASWSYLRFFQKLAPLNCPSLPTTNSQGGQEILVGDASDTFQLIYFFPDLIKPILRPIFNFIYNVVVVKFKVIKPFHDIDIDIGNTIAESRGAKKIMTVEERRRQLALQVLEERMVNP
SIO_010081: YOL107W
subclass of: SO_0000673
so part of: YOL107W
location: 112102..113130
location: region:112102-113130:1
so has part: feature:112102-113130:1:exon

NP_014534.1
type: Protein
SIO_000068: ncbiprotein

S000005467
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:112102-113130:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(113294..113626)
location: region:113294-113626:-1
so has part: feature:113294-113626:-1:region

S000007150
type: SGD
SIO_000068: sgd

position:113294:-1
position: 113294
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:113626:-1
position: 113626
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113294-113626:-1:region

YNCO0002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0002W
so part of: sequence
location: 113802..113874
location: region:113802-113874:1
so has part: feature:113802-113874:1:exon
subclass of: SO_0000663

854045
type: Gene
SIO_000068: ncbigene

position:113802:1
position: 113802
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:113874:1
position: 113874
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113802-113874:1:exon

YNCO0002W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0002W
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0002W
subclass of: SO_0000673
so part of: YNCO0002W
location: 113802..113874
location: region:113802-113874:1
so has part: feature:113802-113874:1:exon

S000006746
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:113802-113874:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1509; Autonomously Replicating Sequence
so part of: sequence
location: 113885..113983
location: region:113885-113983:1
so has part: feature:113885-113983:1:region

S000118486
type: SGD
SIO_000068: sgd

position:113885:1
position: 113885
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:113983:1
position: 113983
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113885-113983:1:region

YOL105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WSC3
locus tag: YOL105C
so part of: sequence
location: complement(<114138..>115808)
location: region:114138-115808:-1
so has part: feature:114138-115808:-1:exon
subclass of: SO_0000010

854046
type: Gene
SIO_000068: ncbigene

position:114138:-1
position: 114138
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:115808:-1
position: 115808
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:114138-115808:-1:exon

YOL105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WSC3
locus tag: YOL105C
product: Wsc3p
transcript id: NM_001183359.1
SIO_010081: YOL105C
subclass of: SO_0000673
so part of: YOL105C
location: complement(<114138..>115808)
location: region:114138-115808:-1
so has part: feature:114138-115808:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:114138-115808:-1:exon

YOL105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WSC3
locus tag: YOL105C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]
experiment: EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:20385774]
note: Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication
codon start: 1
product: Wsc3p
translation: MERVWFAKLTNKGTIKIGYISFILLSLLCQSLIGLVNADFNYEGCYSAADIQSAGLSLKNSYIYQSVSYCQNQCPESAVVALFNGSDCYCGNSVSFLTSLTKSTDSNCGTKCSGWPYQMCGGSSYMNVYVNAETFVSSVESSSSKEGSSTSYMPSTTSSLSSAQISSTTRRTSTDMKSSEMIATTVSTTSTTSSSTSSTTSSTTSSTTSSTTSSTTSSSTSSTTSSTTSSTTSSTTSSTTSSTTSSTTSSTTSSTTSIFSVTSSSSSITLSSSEHTTVDSRTSSPSSTLVPVSSSSSTLSTPKVTSMTPSTSSTIPIVTSVELVTSVVTKAIVSTSDQHQETIFVTRTSVVERSSEVATATAAASNNRSNSTSKQRLSGGAIAGIVIGVVFGVIFIILILLFLIWRRRKSHDQLDLEETKHYQPYSFGDEDANPIGPPPSSGTTNWMRHSRGNTAGSIGTSNMYGFSMSNGANYSSPSSNTSGSIINNLAGLQDATVQKQNLPSTVFEEANTLNSANERFSANSLPDMMMSGPLQVVNPDNPDNPELSSTVSHNRA
SIO_010081: YOL105C
subclass of: SO_0000673
so part of: YOL105C
location: complement(114138..115808)
location: region:114138-115808:-1
so has part: feature:114138-115808:-1:exon

NP_014536.1
type: Protein
SIO_000068: ncbiprotein

S000005465
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:114138-115808:-1:exon

YOL104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAM1
gene: NDJ1
locus tag: YOL104C
gene synonym: TAM1
so part of: sequence
location: complement(<116396..>117454)
location: region:116396-117454:-1
so has part: feature:116396-117454:-1:exon
subclass of: SO_0000010

854047
type: Gene
SIO_000068: ncbigene

position:116396:-1
position: 116396
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:117454:-1
position: 117454
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116396-117454:-1:exon

YOL104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAM1
gene: NDJ1
locus tag: YOL104C
gene synonym: TAM1
product: Ndj1p
transcript id: NM_001183358.1
SIO_010081: YOL104C
subclass of: SO_0000673
so part of: YOL104C
location: complement(<116396..>117454)
location: region:116396-117454:-1
so has part: feature:116396-117454:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116396-117454:-1:exon

YOL104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAM1
gene: NDJ1
locus tag: YOL104C
gene synonym: TAM1
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:25897084|PMID:9157883|PMID:9242487]
experiment: EXISTENCE:direct assay:GO:0007129 homologous chromosome pairing at meiosis [PMID:9157883]
experiment: EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:25897084]
experiment: EXISTENCE:direct assay:GO:0045141 meiotic telomere clustering [PMID:12734403]
experiment: EXISTENCE:genetic interaction:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028|PMID:9157883]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16648465]
experiment: EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18818741|PMID:18818742]
experiment: EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:11018056]
experiment: EXISTENCE:mutant phenotype:GO:0070197 meiotic attachment of telomere to nuclear envelope [PMID:18818741|PMID:18818742]
experiment: EXISTENCE:mutant phenotype:GO:2000711 positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric [PMID:25897084]
note: Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
codon start: 1
product: Ndj1p
translation: MSKDNRLASILLQPVASSSGNCTEFHDSKLHTLQEELNFLPLEGVASNVCPPMFRGHKNYVFVLYCLNQVDLVTNLQDSTKRYYPLQIFKDCQLSSLVQKDFSHYFQLSRQKEGEDRNDSDTTLVNVVNSGVSRHRSQLLKMCIIPRICSFDKSNSKTYKLIQEYVNRFETVLTKFGPEKDFTKVYANWSKLIESFNELILHDLLVKWQQWSELTQPNATVHQNIPNVLRELVIKLTQRYFTFQPSYSCSIDEFTTILLNKNALSLLDVFRKPRKYKLNFGLWLDCQNGILIFTNGIVQMADEITSERVKSFVRPAHLLVLEDHSNDEAVKKLMFFTFSAILQCFTDEILNC
SIO_010081: YOL104C
subclass of: SO_0000673
so part of: YOL104C
location: complement(116396..117454)
location: region:116396-117454:-1
so has part: feature:116396-117454:-1:exon

NP_014537.1
type: Protein
SIO_000068: ncbiprotein

S000005464
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116396-117454:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YOLWTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YOLWTy1-1
so part of: sequence
location: 117703..123628
location: region:117703-123628:1
so has part: feature:117703-123628:1:region

S000007161
type: SGD
SIO_000068: sgd

position:117703:1
position: 117703
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:123628:1
position: 123628
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117703-123628:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 117703..118040
location: region:117703-118040:1
so has part: feature:117703-118040:1:region

S000007154
type: SGD
SIO_000068: sgd

position:118040:1
position: 118040
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117703-118040:1:region

YOL103W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL103W-B
so part of: sequence
location: <118000..>123268
location: region:118000-123268:1
so has part: feature:118000-123268:1:exon
subclass of: SO_0000010

854049
type: Gene
SIO_000068: ncbigene

position:118000:1
position: 118000
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:123268:1
position: 123268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118000-123268:1:exon

YOL103W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL103W-B
product: gag-pol fusion protein
transcript id: NM_001184384.2
SIO_010081: YOL103W-B
subclass of: SO_0000673
so part of: YOL103W-B
location: <118000..>123268
location: region:118000-123268:1
so has part: feature:118000-123268:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:118000-123268:1:exon

YOL103W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL103W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPQISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIINRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YOL103W-B
subclass of: SO_0000673
so part of: YOL103W-B
location: join(118000..119304,119306..123268)
location: region:118000-123268:1
so has part: feature:118000-119304:1:exon
so has part: feature:119306-123268:1:exon

NP_058181.1
type: Protein
SIO_000068: ncbiprotein

S000007350
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:118000-119304:1:exon

position:119304:1
position: 119304
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:119306-123268:1:exon

position:119306:1
position: 119306
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOL103W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL103W-A
so part of: sequence
location: <118000..>119322
location: region:118000-119322:1
so has part: feature:118000-119322:1:exon
subclass of: SO_0000010

854048
type: Gene
SIO_000068: ncbigene

position:119322:1
position: 119322
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118000-119322:1:exon

YOL103W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL103W-A
product: gag protein
transcript id: NM_001184383.1
SIO_010081: YOL103W-A
subclass of: SO_0000673
so part of: YOL103W-A
location: <118000..>119322
location: region:118000-119322:1
so has part: feature:118000-119322:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:118000-119322:1:exon

YOL103W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL103W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPQISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIINRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YOL103W-A
subclass of: SO_0000673
so part of: YOL103W-A
location: 118000..119322
location: region:118000-119322:1
so has part: feature:118000-119322:1:exon

NP_058182.1
type: Protein
SIO_000068: ncbiprotein

S000007349
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:118000-119322:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 123291..123628
location: region:123291-123628:1
so has part: feature:123291-123628:1:region

S000007155
type: SGD
SIO_000068: sgd

position:123291:1
position: 123291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123291-123628:1:region

YOL103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRB612
gene: ITR2
locus tag: YOL103W
gene synonym: HRB612
so part of: sequence
location: <124001..>125830
location: region:124001-125830:1
so has part: feature:124001-125830:1:exon
subclass of: SO_0000010

854050
type: Gene
SIO_000068: ncbigene

position:124001:1
position: 124001
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:125830:1
position: 125830
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:124001-125830:1:exon

YOL103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRB612
gene: ITR2
locus tag: YOL103W
gene synonym: HRB612
product: myo-inositol transporter ITR2
transcript id: NM_001183357.1
SIO_010081: YOL103W
subclass of: SO_0000673
so part of: YOL103W
location: <124001..>125830
location: region:124001-125830:1
so has part: feature:124001-125830:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124001-125830:1:exon

YOL103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRB612
gene: ITR2
locus tag: YOL103W
gene synonym: HRB612
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16233524]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005365 myo-inositol transmembrane transporter activity [PMID:2040626]
experiment: EXISTENCE:mutant phenotype:GO:0015798 myo-inositol transport [PMID:2040626]
note: Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication
codon start: 1
product: myo-inositol transporter ITR2
translation: MKNSTAASSRWTKSRLSHFFPSYTNSSGMGAASTDQSSTQGEELHHRKHCEEDNDGQKPKKSPVSTSTMQIKSRQDEDEDDGRIVIKPVNDEDDTSVIITFNQSISPFIITLTFVASISGFMFGYDTGYISSALISINRDLDNKVLTYGEKELITAATSLGALITSVGAGTAADVFGRRPCLMFSNLMFLIGAILQITAHKFWQMAAGRLIMGFGVGIGSLISPLFISEIAPKMIRGRLTVINSLWLTGGQLIAYGCGAGLNHVKNGWRILVGLSLIPTVLQFSFFCFLPDTPRYYVMKGDLKRAKMVLKRSYVNTEDEIIDQKVEELSSLNQSIPGKNPITKFWNMVKELHTVPSNFRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKIGRRYILLIGLPGMTVALVICAIAFHFLGIKFNGADAVVASDGFSSWGIVIIVFIIVYAAFYALGIGTVPWQQSELFPQNVRGVGTSYATATNWAGSLVIASTFLTMLQNITPTGTFSFFAGVACLSTIFCYFCYPELSGLELEEVQTILKDGFNIKASKALAKKRKQQVAEGAAHHKLKFEPTQEIVES
SIO_010081: YOL103W
subclass of: SO_0000673
so part of: YOL103W
location: 124001..125830
location: region:124001-125830:1
so has part: feature:124001-125830:1:exon

NP_014538.2
type: Protein
SIO_000068: ncbiprotein

S000005463
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124001-125830:1:exon

YOL102C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPT1
locus tag: YOL102C
so part of: sequence
location: complement(<125997..>126689)
location: region:125997-126689:-1
so has part: feature:125997-126689:-1:exon
subclass of: SO_0000010

854051
type: Gene
SIO_000068: ncbigene

position:125997:-1
position: 125997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:126689:-1
position: 126689
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:125997-126689:-1:exon

YOL102C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPT1
locus tag: YOL102C
product: tRNA 2'-phosphotransferase
transcript id: NM_001183356.1
SIO_010081: YOL102C
subclass of: SO_0000673
so part of: YOL102C
location: complement(<125997..>126689)
location: region:125997-126689:-1
so has part: feature:125997-126689:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:125997-126689:-1:exon

YOL102C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPT1
locus tag: YOL102C
EC number: 2.7.1.160
experiment: EXISTENCE:direct assay:GO:0000215 tRNA 2'-phosphotransferase activity [PMID:9148937]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22391451]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22391451]
experiment: EXISTENCE:direct assay:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:9148937]
note: tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
codon start: 1
product: tRNA 2'-phosphotransferase
translation: MRQVLQKDKRDVQLSKALSYLLRHTAVKEKLTIDSNGYTPLKELLSHNRLKTHKCTVDDIHRIVKENDKQRFHIKTLGADEEWICATQGHSIKSIQPSDEVLVPITEASQLPQELIHGTNLQSVIKIIESGAISPMSRNHVHLSPGMLHAKGVISGMRSSSNVYIFIDCHSPLFFQTLKMFRSLNNVYLSSSIPVELIQKVVVKGNLKDEEKLDTLRRILHERNIPLEKI
SIO_010081: YOL102C
subclass of: SO_0000673
so part of: YOL102C
location: complement(125997..126689)
location: region:125997-126689:-1
so has part: feature:125997-126689:-1:exon

NP_014539.1
type: Protein
SIO_000068: ncbiprotein

S000005462
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:125997-126689:-1:exon

YOL101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IZH4
locus tag: YOL101C
so part of: sequence
location: complement(<126982..>127920)
location: region:126982-127920:-1
so has part: feature:126982-127920:-1:exon
subclass of: SO_0000010

854052
type: Gene
SIO_000068: ncbigene

position:126982:-1
position: 126982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:127920:-1
position: 127920
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126982-127920:-1:exon

YOL101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IZH4
locus tag: YOL101C
product: Izh4p
transcript id: NM_001183355.1
SIO_010081: YOL101C
subclass of: SO_0000673
so part of: YOL101C
location: complement(<126982..>127920)
location: region:126982-127920:-1
so has part: feature:126982-127920:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:126982-127920:-1:exon

YOL101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IZH4
locus tag: YOL101C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0006882 cellular zinc ion homeostasis [PMID:15060275]
note: Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication
codon start: 1
product: Izh4p
translation: MVSLTTIEQSPVKCETTTEKESNDTRGTDSNENAETKETKKGFPFHDLAKLQKQYKNKSSRNESLVALIYLLGSMLSFCLLIFFTDFYLIPLFPTTTTMTDYIVFNFYLLNVFVFCMVHFIYHFVKNISLQQHLEHWQKFSYLSNINLLISSQITILYYLFYDYVFFFKIFTLLMNFIGLVAYFFILTDKLISSKRFNKTVFFISVSVVCCSLPLLTAIITFDGLENLKERIKVNAITWELVALVAASIIYVTRFPESLFRRNKKEEGWNHSEYLFHLLISGTAFYHFFILIQSYILMHSSLNQPELINFKS
SIO_010081: YOL101C
subclass of: SO_0000673
so part of: YOL101C
location: complement(126982..127920)
location: region:126982-127920:-1
so has part: feature:126982-127920:-1:exon

NP_014540.1
type: Protein
SIO_000068: ncbiprotein

S000005461
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:126982-127920:-1:exon

YOL100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PKH2
locus tag: YOL100W
so part of: sequence
location: <129237..>132482
location: region:129237-132482:1
so has part: feature:129237-132482:1:exon
subclass of: SO_0000010

854053
type: Gene
SIO_000068: ncbigene

position:129237:1
position: 129237
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:132482:1
position: 132482
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129237-132482:1:exon

YOL100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PKH2
locus tag: YOL100W
product: serine/threonine protein kinase PKH2
transcript id: NM_001183354.1
SIO_010081: YOL100W
subclass of: SO_0000673
so part of: YOL100W
location: <129237..>132482
location: region:129237-132482:1
so has part: feature:129237-132482:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129237-132482:1:exon

YOL100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PKH2
locus tag: YOL100W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:10567559|PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22918958]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12221112]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12221112]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:18034155]
experiment: EXISTENCE:genetic interaction:GO:0000196 cell wall integrity MAPK cascade [PMID:10567559]
experiment: EXISTENCE:genetic interaction:GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly [PMID:21163942]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22918958]
experiment: EXISTENCE:genetic interaction:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:21163942]
experiment: EXISTENCE:mutant phenotype:GO:0000196 cell wall integrity MAPK cascade [PMID:10567559]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22918958]
experiment: EXISTENCE:mutant phenotype:GO:0071902 positive regulation of protein serine/threonine kinase activity [PMID:12221112]
note: Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase PKH2
translation: MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDRKLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINLRQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKRS
SIO_010081: YOL100W
subclass of: SO_0000673
so part of: YOL100W
location: 129237..132482
location: region:129237-132482:1
so has part: feature:129237-132482:1:exon

NP_014541.1
type: Protein
SIO_000068: ncbiprotein

S000005460
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129237-132482:1:exon

YOL098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDD3
locus tag: YOL098C
so part of: sequence
location: complement(<132725..>135838)
location: region:132725-135838:-1
so has part: feature:132725-135838:-1:exon
subclass of: SO_0000010

854055
type: Gene
SIO_000068: ncbigene

position:132725:-1
position: 132725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135838:-1
position: 135838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:132725-135838:-1:exon

YOL098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDD3
locus tag: YOL098C
product: Sdd3p
transcript id: NM_001183352.1
SIO_010081: YOL098C
subclass of: SO_0000673
so part of: YOL098C
location: complement(<132725..>135838)
location: region:132725-135838:-1
so has part: feature:132725-135838:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:132725-135838:-1:exon

YOL098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDD3
locus tag: YOL098C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P
codon start: 1
product: Sdd3p
translation: MGFKKLVSFQPDYVPQYHITKYISERTKLQLVHINHKTSPLVHGYFAVPTECLNDSGAPHTLEHLIFMGSKSYPYKGLLDTAGNLSLSNTNAWTDTDQTVYTLSSAGWKGFSKLLPAYLDHILHPTLTDEACLTEVYHIDPENLGDKGVVFSEMEAIETQGWYISGLEKQRLMFPEGSGYRSETGGLTKNLRTLTNDEIRQFHKSLYSSDNLCVIVCGNVPTDELLTVMEEWDNKLPEIPSNIPKKRPFLDNKLSHIPQSRDKVTESTVEFPELDESQGELLFSWIGVPYSDFRNDLAVDVLLDYFTDSALAVFTRELVEIDDPMANSTDCCTDYFMRTIIDLRIQGVPTEKIAATKTKVLEILKTHTIDLSRVRQVVENTKWEYLLNYEKNGESRFSSAVITDYIYGNEDGSSLVSSLKDLSDFDALLQWSQKDWQSLLNRIFVDNKPIIVTAKPSALMYEQLEKEKSDLIKQREAEFDDEKKLVLLKRLNNAKNINDRPIPKSLLQKFEIDNPSKSVEFVNTKSIATVDSYKYNNVSDPLTKKILETRPDNFPLFIHLNHFPSQFIELHFLVNSASIKDTSLLPYFNMFDELFSMPMKILDEESNVETMLSFEEVVAKLKSETIDAQINQGLKGSCPDLINFKIQCRAGGYSNSVQWIKHCLFDMVFDENRVRILLENYLNSIVEWKRNGNVMLSSLTNRNLYSARSLKKSTDPLFVEAKLQEIFAEIENGNFEKEILPRIETMRKQLRANFNKFHILVLGDISKIDDVYEPWNPLIKCLNIAHPVEKLKIPPVPRALDTISSICRTPGEKAFIITTPASESAYMNLITSIPFNLDYHDPEYAIVSLASEYLECVEGPFWKGIRGAGLAYGASMLKLCEINSWGFNIYRGADIIKCYEVGKQIVQDYASGALEFDEQLIQGAISSIINRLATIECGYFETALSKYVDEFCLQRGNNFNELYLERLQNVTKTDLKNAMQKYFVNMFDSNKSVAFVSCHPAKLESVQEFFETQGFTVEIEELEDDDDEIDSEEDENA
SIO_010081: YOL098C
subclass of: SO_0000673
so part of: YOL098C
location: complement(132725..135838)
location: region:132725-135838:-1
so has part: feature:132725-135838:-1:exon

NP_014543.1
type: Protein
SIO_000068: ncbiprotein

S000005458
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:132725-135838:-1:exon

YNCO0003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR58
locus tag: YNCO0003C
so part of: sequence
location: complement(136088..136183)
location: region:136088-136183:-1
so has part: feature:136088-136183:-1:exon
subclass of: SO_0000578

9164976
type: Gene
SIO_000068: ncbigene

position:136088:-1
position: 136088
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:136183:-1
position: 136183
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136088-136183:-1:exon

YNCO0003C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR58
locus tag: YNCO0003C
product: SNR58
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position C663
transcript id: NR_132255.1
SIO_010081: YNCO0003C
subclass of: SO_0000673
so part of: YNCO0003C
location: complement(136088..136183)
location: region:136088-136183:-1
so has part: feature:136088-136183:-1:exon

S000006449
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136088-136183:-1:exon

YOL097W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL097W-A
so part of: sequence
location: <136220..>136405
location: region:136220-136405:1
so has part: feature:136220-136405:1:exon
subclass of: SO_0000010

1466475
type: Gene
SIO_000068: ncbigene

position:136220:1
position: 136220
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:136405:1
position: 136405
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136220-136405:1:exon

YOL097W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL097W-A
product: uncharacterized protein
transcript id: NM_001184665.1
SIO_010081: YOL097W-A
subclass of: SO_0000673
so part of: YOL097W-A
location: <136220..>136405
location: region:136220-136405:1
so has part: feature:136220-136405:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:136220-136405:1:exon

YOL097W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL097W-A
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MQSMICSSEHENLTCKYWPVSFLASWCENGSGTLMQKDGSLLYAVKNFSHIFEKKIFHTNL
SIO_010081: YOL097W-A
subclass of: SO_0000673
so part of: YOL097W-A
location: 136220..136405
location: region:136220-136405:1
so has part: feature:136220-136405:1:exon

NP_878163.1
type: Protein
SIO_000068: ncbiprotein

S000028854
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136220-136405:1:exon

YOL097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRE342
gene: WRS1
locus tag: YOL097C
gene synonym: HRE342
so part of: sequence
location: complement(<136527..>137825)
location: region:136527-137825:-1
so has part: feature:136527-137825:-1:exon
subclass of: SO_0000010

854056
type: Gene
SIO_000068: ncbigene

position:136527:-1
position: 136527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:137825:-1
position: 137825
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136527-137825:-1:exon

YOL097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRE342
gene: WRS1
locus tag: YOL097C
gene synonym: HRE342
product: tryptophan--tRNA ligase WRS1
transcript id: NM_001183351.1
SIO_010081: YOL097C
subclass of: SO_0000673
so part of: YOL097C
location: complement(<136527..>137825)
location: region:136527-137825:-1
so has part: feature:136527-137825:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:136527-137825:-1:exon

YOL097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRE342
gene: WRS1
locus tag: YOL097C
gene synonym: HRE342
EC number: 6.1.1.2
experiment: EXISTENCE:direct assay:GO:0004830 tryptophan-tRNA ligase activity [PMID:9046085]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant
codon start: 1
product: tryptophan--tRNA ligase WRS1
translation: MSNDETVEKVTQQVSELKSTDVKEQVVTPWDVEGGVDEQGRAQNIDYDKLIKQFGTKPVNEETLKRFKQVTGREPHHFLRKGLFFSERDFTKILDLYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQEVFDVPLVIELTDDEKFLFKHKLTINDVKNFARENAKDIIAVGFDPKNTFIFSDLQYMGGAFYETVVRVSRQITGSTAKAVFGFNDSDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDPYFRVCRDVADKLKYSKPALLHSRFFPALQGSTTKMSASDDTTAIFMTDTPKQIQKKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLSFFKDDDVFLKECYDKYKSGELLSGEMKKLCIETLQEFVKAFQERRAQVDEETLDKFMVPHKLVWGEKERLVAPKPKTKQEKK
SIO_010081: YOL097C
subclass of: SO_0000673
so part of: YOL097C
location: complement(136527..137825)
location: region:136527-137825:-1
so has part: feature:136527-137825:-1:exon

NP_014544.1
type: Protein
SIO_000068: ncbiprotein

S000005457
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136527-137825:-1:exon

YOL096C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COQ3
locus tag: YOL096C
so part of: sequence
location: complement(<138107..>139045)
location: region:138107-139045:-1
so has part: feature:138107-139045:-1:exon
subclass of: SO_0000010

854057
type: Gene
SIO_000068: ncbigene

position:138107:-1
position: 138107
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139045:-1
position: 139045
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138107-139045:-1:exon

YOL096C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COQ3
locus tag: YOL096C
product: hexaprenyldihydroxybenzoate methyltransferase
transcript id: NM_001183350.1
SIO_010081: YOL096C
subclass of: SO_0000673
so part of: YOL096C
location: complement(<138107..>139045)
location: region:138107-139045:-1
so has part: feature:138107-139045:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138107-139045:-1:exon

YOL096C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COQ3
locus tag: YOL096C
EC number: 2.1.1.64
EC number: 2.1.1.114
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10760477|PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10419476]
experiment: EXISTENCE:direct assay:GO:0006744 ubiquinone biosynthetic process [PMID:10419476]
experiment: EXISTENCE:mutant phenotype:GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity [PMID:1885593]
experiment: EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:1885593]
experiment: EXISTENCE:mutant phenotype:GO:0061543 3-demethylubiquinol-6 3-O-methyltransferase activity [PMID:10419476]
note: O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
codon start: 1
product: hexaprenyldihydroxybenzoate methyltransferase
translation: MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN
SIO_010081: YOL096C
subclass of: SO_0000673
so part of: YOL096C
location: complement(138107..139045)
location: region:138107-139045:-1
so has part: feature:138107-139045:-1:exon

NP_014545.2
type: Protein
SIO_000068: ncbiprotein

S000005456
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138107-139045:-1:exon

YOL095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HMI1
locus tag: YOL095C
so part of: sequence
location: complement(<139227..>141347)
location: region:139227-141347:-1
so has part: feature:139227-141347:-1:exon
subclass of: SO_0000010

854058
type: Gene
SIO_000068: ncbigene

position:139227:-1
position: 139227
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141347:-1
position: 141347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139227-141347:-1:exon

YOL095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HMI1
locus tag: YOL095C
product: ATP-dependent 3'-5' DNA helicase
transcript id: NM_001183349.1
SIO_010081: YOL095C
subclass of: SO_0000673
so part of: YOL095C
location: complement(<139227..>141347)
location: region:139227-141347:-1
so has part: feature:139227-141347:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:139227-141347:-1:exon

YOL095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HMI1
locus tag: YOL095C
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10409639]
experiment: EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:16358299]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:10669756]
experiment: EXISTENCE:mutant phenotype:GO:0032042 mitochondrial DNA metabolic process [PMID:16358299]
note: Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
codon start: 1
product: ATP-dependent 3'-5' DNA helicase
translation: MDKLTPSQWKVINKSYEPASTIKVIAGPGSGKTLTLLYKVLHLITVENIKPEEILIFSLTNKAVDSIIENLLSIFENSHTNKEIVHQIGCYTVHGLANRIVVENEGMINIIEEIGWRGLMKLLPPSKRTPHHFRSYKELEKVVKDYKLNNAKNNNPVIEKLVELMDNCKVMTNDDLIIRAKKYLELDSSDSDASSFTQDLRNKYKVVLIDEFQDLYPSLAPLITMICKGKQLIMFGDTNQSIYGFLGSNNEIMSQLDNLHPKNSTTVLKLFDNFRSTPEIISLASKIINRPLAEKQIIDDTDETPSELVRKLPSGVSPQIMTFDDLAAESEFIIDKITQLICSSAKFSDIAILSRTNSHLTAIASILKKYGIPYQKLKSQPDWMDDLRIQFLLDILKVCSLASDEKHNREFNTGDKWQSNFSILVTMSALKGIGDASIQALYKACSLKNLSIWKYLTMVPNFEWPLGLSIKKKMENYTSNLYEMIENDQVHQLDDPMELLEKVASITNNLNLNPTYFQSLSDAQSSLEFKTHLQEMAQVMKVSKSNKPPGISFVKWFLETYFDQTMVFHQSQQALQTTGPGTVKLSTIHSAKGLEFPIVFLTNGSMSNFPMDTNALYVGITRARNLLYMCNMKHERLVSKSSPYSRNIMSNNLFWTYYNKDLKRSVCDVKVTHGYNVQRYNQLRKNFGFYRAYSSLRGCKSVFRRI
SIO_010081: YOL095C
subclass of: SO_0000673
so part of: YOL095C
location: complement(139227..141347)
location: region:139227-141347:-1
so has part: feature:139227-141347:-1:exon

NP_014546.1
type: Protein
SIO_000068: ncbiprotein

S000005455
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:139227-141347:-1:exon

YOL094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RFC4
locus tag: YOL094C
so part of: sequence
location: complement(<141584..>142555)
location: region:141584-142555:-1
so has part: feature:141584-142555:-1:exon
subclass of: SO_0000010

854059
type: Gene
SIO_000068: ncbigene

position:141584:-1
position: 141584
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:142555:-1
position: 142555
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141584-142555:-1:exon

YOL094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RFC4
locus tag: YOL094C
product: replication factor C subunit 4
transcript id: NM_001183348.1
SIO_010081: YOL094C
subclass of: SO_0000673
so part of: YOL094C
location: complement(<141584..>142555)
location: region:141584-142555:-1
so has part: feature:141584-142555:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141584-142555:-1:exon

YOL094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RFC4
locus tag: YOL094C
experiment: EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:12604797|PMID:8995429]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:8063832]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]
experiment: EXISTENCE:direct assay:GO:0007062 sister chromatid cohesion [PMID:11389843]
experiment: EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797]
experiment: EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]
experiment: EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]
experiment: EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12909721|PMID:12912927]
note: Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: replication factor C subunit 4
translation: MSKTLSLQLPWVEKYRPQVLSDIVGNKETIDRLQQIAKDGNMPHMIISGMPGIGKTTSVHCLAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHLPPGKHKIVILDEADSMTAGAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSRCAILRYSKLSDEDVLKRLLQIIKLEDVKYTNDGLEAIIFTAEGDMRQAINNLQSTVAGHGLVNADNVFKIVDSPHPLIVKKMLLASNLEDSIQILRTDLWKKGYSSIDIVTTSFRVTKNLAQVKESVRLEMIKEIGLTHMRILEGVGTYLQLASMLAKIHKLNNKA
SIO_010081: YOL094C
subclass of: SO_0000673
so part of: YOL094C
location: complement(141584..142555)
location: region:141584-142555:-1
so has part: feature:141584-142555:-1:exon

NP_014547.1
type: Protein
SIO_000068: ncbiprotein

S000005454
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141584-142555:-1:exon

YOL093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM10
locus tag: YOL093W
so part of: sequence
location: <142815..>143696
location: region:142815-143696:1
so has part: feature:142815-143696:1:exon
subclass of: SO_0000010

854060
type: Gene
SIO_000068: ncbigene

position:142815:1
position: 142815
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:143696:1
position: 143696
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:142815-143696:1:exon

YOL093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM10
locus tag: YOL093W
product: tRNA (guanine(9)-N(1))-methyltransferase
transcript id: NM_001183347.1
SIO_010081: YOL093W
subclass of: SO_0000673
so part of: YOL093W
location: <142815..>143696
location: region:142815-143696:1
so has part: feature:142815-143696:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:142815-143696:1:exon

YOL093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM10
locus tag: YOL093W
EC number: 2.1.1.221
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016423 tRNA (guanine) methyltransferase activity [PMID:12702816]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:12702816]
note: tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator
codon start: 1
product: tRNA (guanine(9)-N(1))-methyltransferase
translation: MSNDEINQNEEKVKRTPPLPPVPEGMSKKQWKKMCKRQRWEENKAKYNAERRVKKKRLRHERSAKIQEYIDRGEEVPQELIREPRINVNQTDSGIEIILDCSFDELMNDKEIVSLSNQVTRAYSANRRANHFAEIKVAPFDKRLKQRFETTLKNTNYENWNHFKFLPDDKIMFGDEHISKDKIVYLTADTEEKLEKLEPGMRYIVGGIVDKNRYKELCLKKAQKMGIPTRRLPIDEYINLEGRRVLTTTHVVQLMLKYFDDHNWKNAFESVLPPRKLDAEAKSASSSPAPKDT
SIO_010081: YOL093W
subclass of: SO_0000673
so part of: YOL093W
location: 142815..143696
location: region:142815-143696:1
so has part: feature:142815-143696:1:exon

NP_014548.1
type: Protein
SIO_000068: ncbiprotein

S000005453
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:142815-143696:1:exon

YOL092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPQ1
locus tag: YOL092W
so part of: sequence
location: <144204..>145130
location: region:144204-145130:1
so has part: feature:144204-145130:1:exon
subclass of: SO_0000010

854061
type: Gene
SIO_000068: ncbigene

position:144204:1
position: 144204
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145130:1
position: 145130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144204-145130:1:exon

YOL092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPQ1
locus tag: YOL092W
product: cationic amino acid transporter
transcript id: NM_001183346.1
SIO_010081: YOL092W
subclass of: SO_0000673
so part of: YOL092W
location: <144204..>145130
location: region:144204-145130:1
so has part: feature:144204-145130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:144204-145130:1:exon

YOL092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPQ1
locus tag: YOL092W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23169667|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:23169667]
experiment: EXISTENCE:mutant phenotype:GO:0034488 basic amino acid transmembrane export from vacuole [PMID:23169667]
note: Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication
codon start: 1
product: cationic amino acid transporter
translation: MQLVPLELNRSTLSGISGSISISCWIIVFVPQIYENFYRKSSDGLSLLFVVLWLAGDVFNLMGAVMQHLLSTMIILAAYYTVADIILLGQCLWYDNEEKPAVDPIHLSPANPINENVLHDVFNEQQPLLNSQGQPNRIDEEMAAPSSDGNAGDDNLREVNSRNLIKDIFIVSGVVFVGFISWYVTYCVNYTQPPPVEDPSLPVPELQINWMAQIFGYLSALLYLGSRIPQILLNFKRKSCEGISFLFFLFACLGNTTFIFSVIVISLDWKYLIMNASWLVGSIGTLFMDFVIFSQFFIYKRNKKFILN
SIO_010081: YOL092W
subclass of: SO_0000673
so part of: YOL092W
location: 144204..145130
location: region:144204-145130:1
so has part: feature:144204-145130:1:exon

NP_014549.1
type: Protein
SIO_000068: ncbiprotein

S000005452
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:144204-145130:1:exon

YOL091W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPC70
gene: SPO21
locus tag: YOL091W
gene synonym: MPC70
so part of: sequence
location: <145334..>147163
location: region:145334-147163:1
so has part: feature:145334-147163:1:exon
subclass of: SO_0000010

854062
type: Gene
SIO_000068: ncbigene

position:145334:1
position: 145334
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147163:1
position: 147163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145334-147163:1:exon

YOL091W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPC70
gene: SPO21
locus tag: YOL091W
gene synonym: MPC70
product: Spo21p
transcript id: NM_001183345.1
SIO_010081: YOL091W
subclass of: SO_0000673
so part of: YOL091W
location: <145334..>147163
location: region:145334-147163:1
so has part: feature:145334-147163:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145334-147163:1:exon

YOL091W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPC70
gene: SPO21
locus tag: YOL091W
gene synonym: MPC70
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:10899120]
experiment: EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]
note: Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication
codon start: 1
product: Spo21p
translation: MDNILKASNMEGTSTMTVTSRSSEDSSCISNHEQDTDTHKDGDTSGLENSKISKRKWMKEFFKLSKSPASKSSRSIGSMKSNQSLVSMKSSDDGNSYKNDYSSICGNSLPSAGLSRSNSVKELKLDSTGSQRSKNNVAMLARSSTTSQTTCSSSSSSSSYNSIKGNENDILLQNNNHFRHNKEIPQSKGSSNINTASIMSQYNVDTQATAIMSDMQKQYDSQQMTSPFVNEDLHFDPNGEVSHVIKAIFKEIGYKYDDFSDIPVFQLMQEMYQLVKKNSSARRTKITDYASKLKEKEAQLKSQNDKILKLETTNKAYKTKYKEVSLENKKIKEAFKELDNESYNHDEELLKKYKYTRETLDRVNREQQLIIDQNEFLKKSVNELQNEVNATNFKFSLFKEKYAKLADSITELNTSTKKREALGENLTFECNELKEICLKYKKNIENISNTNKNLQNSFKNERKKVLDLRNERNLLKKEILLIECHGSYSLLLVSNILTCYRFLLPSDTIIETESLIKELLNMNNSLSNHVSSSDEPPAEYSKRLELKCVEFEEKLLYFYQELVTKKIIDVIYKCFINYYKKSRQTDQKSNQNSSTPYKQSQRQVPHSIK
SIO_010081: YOL091W
subclass of: SO_0000673
so part of: YOL091W
location: 145334..147163
location: region:145334-147163:1
so has part: feature:145334-147163:1:exon

NP_014550.1
type: Protein
SIO_000068: ncbiprotein

S000005451
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145334-147163:1:exon

YOL090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PMS5
gene: MSH2
locus tag: YOL090W
gene synonym: PMS5
so part of: sequence
location: <147382..>150276
location: region:147382-150276:1
so has part: feature:147382-150276:1:exon
subclass of: SO_0000010

854063
type: Gene
SIO_000068: ncbigene

position:147382:1
position: 147382
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150276:1
position: 150276
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:147382-150276:1:exon

YOL090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PMS5
gene: MSH2
locus tag: YOL090W
gene synonym: PMS5
product: mismatch repair ATPase MSH2
transcript id: NM_001183344.1
SIO_010081: YOL090W
subclass of: SO_0000673
so part of: YOL090W
location: <147382..>150276
location: region:147382-150276:1
so has part: feature:147382-150276:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:147382-150276:1:exon

YOL090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PMS5
gene: MSH2
locus tag: YOL090W
gene synonym: PMS5
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:10882115]
experiment: EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:10066781|PMID:9018043]
experiment: EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:16781730]
experiment: EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:16781730]
experiment: EXISTENCE:direct assay:GO:0000406 double-strand/single-strand DNA junction binding [PMID:16781730]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9545323]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9819445]
experiment: EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:8805366]
experiment: EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:8816473]
experiment: EXISTENCE:direct assay:GO:0032138 single base insertion or deletion binding [PMID:8816473]
experiment: EXISTENCE:genetic interaction:GO:0000735 removal of nonhomologous ends [PMID:9256462]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16157874]
experiment: EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]
experiment: EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:1334021|PMID:16702432|PMID:8056309]
experiment: EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:10523644|PMID:9256462]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:10523644|PMID:9520271]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:15920474]
experiment: EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:1334021]
experiment: EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:8849883]
experiment: EXISTENCE:mutant phenotype:GO:0032138 single base insertion or deletion binding [PMID:9111312]
experiment: EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:27045900]
experiment: EXISTENCE:physical interaction:GO:0032301 MutSalpha complex [PMID:8816473]
experiment: EXISTENCE:physical interaction:GO:0032302 MutSbeta complex [PMID:8805366]
note: Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres
codon start: 1
product: mismatch repair ATPase MSH2
translation: MSSTRPELKFSDVSEERNFYKKYTGLPKKPLKTIRLVDKGDYYTVIGSDAIFVADSVYHTQSVLKNCQLDPVTAKNFHEPTKYVTVSLQVLATLLKLCLLDLGYKVEIYDKGWKLIKSASPGNIEQVNELMNMNIDSSIIIASLKVQWNSQDGNCIIGVAFIDTTAYKVGMLDIVDNEVYSNLESFLIQLGVKECLVQDLTSNSNSNAEMQKVINVIDRCGCVVTLLKNSEFSEKDVELDLTKLLGDDLALSLPQKYSKLSMGACNALIGYLQLLSEQDQVGKYELVEHKLKEFMKLDASAIKALNLFPQGPQNPFGSNNLAVSGFTSAGNSGKVTSLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYLIDQIELRQMLTSEYLPMIPDIRRLTKKLNKRGNLEDVLKIYQFSKRIPEIVQVFTSFLEDDSPTEPVNELVRSVWLAPLSHHVEPLSKFEEMVETTVDLDAYEENNEFMIKVEFNEELGKIRSKLDTLRDEIHSIHLDSAEDLGFDPDKKLKLENHHLHGWCMRLTRNDAKELRKHKKYIELSTVKAGIFFSTKQLKSIANETNILQKEYDKQQSALVREIINITLTYTPVFEKLSLVLAHLDVIASFAHTSSYAPIPYIRPKLHPMDSERRTHLISSRHPVLEMQDDISFISNDVTLESGKGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIVDELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMHVVAHIEKNLKEQKHDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDLKTNNEDLKKAKLSLQEVNEGNIRLKALLKEWIRKVKEEGLHDPSKITEEASQHKIQELLRAIANEPEKENDNYLKYIKALLL
SIO_010081: YOL090W
subclass of: SO_0000673
so part of: YOL090W
location: 147382..150276
location: region:147382-150276:1
so has part: feature:147382-150276:1:exon

NP_014551.1
type: Protein
SIO_000068: ncbiprotein

S000005450
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:147382-150276:1:exon

YOL089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HAL9
locus tag: YOL089C
so part of: sequence
location: complement(<150398..>153490)
location: region:150398-153490:-1
so has part: feature:150398-153490:-1:exon
subclass of: SO_0000010

854064
type: Gene
SIO_000068: ncbigene

position:150398:-1
position: 150398
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:153490:-1
position: 153490
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150398-153490:-1:exon

YOL089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HAL9
locus tag: YOL089C
product: Hal9p
transcript id: NM_001183343.1
SIO_010081: YOL089C
subclass of: SO_0000673
so part of: YOL089C
location: complement(<150398..>153490)
location: region:150398-153490:-1
so has part: feature:150398-153490:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:150398-153490:-1:exon

YOL089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HAL9
locus tag: YOL089C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11943786|PMID:9559673]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9559673]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11943786|PMID:9559673]
note: Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication
codon start: 1
product: Hal9p
translation: MENQGGDYSPNGFSNSASNMNAVFNNEITGRSDISNVNHQTGTPRLVPETQIWSMPVPDQLMTMPNRENTLMTGSTIGPNIPMNVAYPNTIYSPTEHQSQFQTQQNRDISTMMEHTNSNDMSGSGKNLKKRVSKACDHCRKRKIRCDEVDQQTKKCSNCIKFQLPCTFKHRDEILKKKRKLEIKHHATPGESLQTSNSISNPVASSSVPNSGRFELLNGNSPLESNIIDKVSNIQNNLNKKMNSKIEKLDRKMSYIIDSVARLEWLLDKAVKKQEGKYKEKNNLPKPARKIYSTALLTAQKLYWFKQSLGVKASNEEFLSPISEILSISLKWYATQMKKFMDLSSPAFFSSEIILYSLPPKKQAKRLLENFHATLLSSVTGIISLKECLDLAEKYYSESGEKLTYPEHLLLNVCLCSGASATQSIIRGDSKFLRKDRYDPTSQELKKIENVALLNAMYYYHKLSTICSGTRTLQALLLLNRYFQLTYDTELANCILGTAIRLAVDMELNRKSSYKSLDFEEAIRRRRMWWHCFCTDKLYSLMLSRPPIVGERDMDMLTDQNYYEVIKTNILPDLIDKKEDLDKITDVNSALNVVVNFCQHISLFISYYVSKLVSIESKIYSTCFAVRSTLDLSFDAMLDKIKDLNDSLNNWRDNLHVSMKLKSYKQYLSVLYAQKSQENPALSFEIACSRVLNCHFRALYSKVILSMMTTSLLIDNERLYKGSRHDIPQLFILFSSQYLNASKEMLQLFQGINYQAHMYNEVMYQFSTAMFVLFFYVVDNMNDLKKKGEVKEIIDILKKSYDRLVGENDEQLLFDNVKWNTLIVFYSHFLKYVLQRYHALNDSTSIFDSKPYDETITKVIMHSRKIKDETVDQLIMSLKSYGSLHSLQKGNEADLADDGLNTNDISSEDFAEEAPINLFGELSVEILKLLKSHSPISNFGDLSPSSNRKGISDDSSLYPIRSDLTSLVYPIHSSDTGDTLSSGLETPENSNFNSDSGIKEDFEAFRALLPLGKLIYDRDYSFVNTFRDYE
SIO_010081: YOL089C
subclass of: SO_0000673
so part of: YOL089C
location: complement(150398..153490)
location: region:150398-153490:-1
so has part: feature:150398-153490:-1:exon

NP_014552.1
type: Protein
SIO_000068: ncbiprotein

S000005449
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:150398-153490:-1:exon

YOL088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPD2
locus tag: YOL088C
so part of: sequence
location: complement(<153912..>154745)
location: region:153912-154745:-1
so has part: feature:153912-154745:-1:exon
subclass of: SO_0000010

854065
type: Gene
SIO_000068: ncbigene

position:153912:-1
position: 153912
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:154745:-1
position: 154745
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153912-154745:-1:exon

YOL088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPD2
locus tag: YOL088C
product: protein disulfide isomerase MPD2
transcript id: NM_001183342.1
SIO_010081: YOL088C
subclass of: SO_0000673
so part of: YOL088C
location: complement(<153912..>154745)
location: region:153912-154745:-1
so has part: feature:153912-154745:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153912-154745:-1:exon

YOL088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPD2
locus tag: YOL088C
EC number: 5.3.4.1
experiment: EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:16002399]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:16002399]
experiment: EXISTENCE:genetic interaction:GO:0003756 protein disulfide isomerase activity [PMID:11157982]
experiment: EXISTENCE:genetic interaction:GO:0005783 endoplasmic reticulum [PMID:15377672]
experiment: EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:11157982]
experiment: EXISTENCE:genetic interaction:GO:0015035 protein-disulfide reductase activity [PMID:11157982]
experiment: EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]
note: Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
codon start: 1
product: protein disulfide isomerase MPD2
translation: MKLHGFLFSVLSTCVVILPALAYSEAVTMVKSIEQYFDICNRNDSYTMIKYYTSWCQHCKTLAPVYEELGELYAKKANKDDTPINFLEVNCEFFGPTLCTDLPGFPIIELVKPRTKPLVLPKLDWSSMKFHERLWQRIKTWFNNPKYQLDTSRVVRFEGSRNLKSLSNFIDTVRSKDTEERFIEHIFDDSRNCNEELRSQQLLCKAGKEYYSDTLSKLYGDVNGLEKERRRLEALIKQNGDDLSKEVKEKLKIIRLQLSLLSHIEDQLEDTSSHDEL
SIO_010081: YOL088C
subclass of: SO_0000673
so part of: YOL088C
location: complement(153912..154745)
location: region:153912-154745:-1
so has part: feature:153912-154745:-1:exon

NP_014553.1
type: Protein
SIO_000068: ncbiprotein

S000005448
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153912-154745:-1:exon

YOL087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUF1
locus tag: YOL087C
so part of: sequence
location: complement(<155287..>158637)
location: region:155287-158637:-1
so has part: feature:155287-158637:-1:exon
subclass of: SO_0000010

854066
type: Gene
SIO_000068: ncbigene

position:155287:-1
position: 155287
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:158637:-1
position: 158637
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:155287-158637:-1:exon

YOL087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUF1
locus tag: YOL087C
product: Duf1p
transcript id: NM_001183341.1
SIO_010081: YOL087C
subclass of: SO_0000673
so part of: YOL087C
location: complement(<155287..>158637)
location: region:155287-158637:-1
so has part: feature:155287-158637:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:155287-158637:-1:exon

YOL087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUF1
locus tag: YOL087C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]
note: Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
codon start: 1
product: Duf1p
translation: MNQLTVSYGLISPDYCTSQDAHILPITKILYPDIPGKNYFLTSGRDGSIILHKNTQLSNEPETAATTIKNDAIRMQVHSDWASDLIHVNMKNSDPSAGDTFISVSHDFSIVLISVNAQLTTWDKKIIGDHDDYIKCIVPIHYEMSNDYELEEQEGGPDNVHDGINNGIVVDEQNNFLFVTGGLDRKIKLWCLSSGPEKMATLLHTFDNAQSNDTGSIYSMSPIIPKYSFDDNQTSRPFDFVAGDCNGDLIFYSCKYRKEVIRIQNAHRTNIKVVRTLDDSTRLISTSSDGVINVWDLNCRHDQTTGALQLPKKIGSWSWDSSIWCVQGTSLDKLYFGDSQGNVMRANLSSYEDAKLTRIFKPDHHHHHHHHHEHEEQNISTTDAKVKKYGGILDIALLPNEKLLFSFCTDSNLNVLDLTNNHFSVNEGGFALTRSSLLTNRRHVITENTKGQMQRWDIVSCELLNTFDSSEGSFDDIVMKYTSKEILSHWCTVSVKVGMLFVKINPKFLKTEVYGSALKDYQVVNNIEINSDERYNLGKIVINSLFNEFISYEVQKDKLLRKKIFSLKKKDLTNSLTLDTGYNSESKKNNKDKKRKSTFKISSTLSIGNTNSSGTPPNSAPATPVMAETIVLEEQPLLQSASDKAIDDSLELVQPLPASKKPYFRTQSSGSLLSRKFKSFRSTSGRATTGLNTPEEPKGILPDTPHVINDDSAFPQAINTTQQSKDATPESMLWNHPFKLEQKLSAISSQDLPSNNTHNKLRSSENSRANSTSTLEGNEKKKPEFMPDLLEQIQESYKQQYMNTSSLKYLTKRLPVTKIIKASSCPIIRVKSATLVLVHLWKEGSCGGRVLFSTLLPPSHVDNETVSGGKENSKPPDDEEVDLQAVDDDKLGKYDLIDGELGSRLNRRQIFEQLEENLPYWFAKALFRDIKTVEEQPKLNFLIMPWSSVGGSEAAGNENKKKFISASDTTESSGNDSSDSSLGNGNEAVSPSTQQQFHNMLKFGRPKTSEQELNPTDLPRISEANVKLVAPGMIRVKKIKLYVADRFETKTPEMKAKMEPSLWLDLLCRGQVLDNDMTLNTVRTLYWKSQGDIVLEYRRKVHNSPLVHEVNGNEGK
SIO_010081: YOL087C
subclass of: SO_0000673
so part of: YOL087C
location: complement(155287..158637)
location: region:155287-158637:-1
so has part: feature:155287-158637:-1:exon

NP_014554.1
type: Protein
SIO_000068: ncbiprotein

S000005447
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:155287-158637:-1:exon

YOL086W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MHF1
locus tag: YOL086W-A
so part of: sequence
location: <159173..>159445
location: region:159173-159445:1
so has part: feature:159173-159445:1:exon
subclass of: SO_0000010

854067
type: Gene
SIO_000068: ncbigene

position:159173:1
position: 159173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159445:1
position: 159445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159173-159445:1:exon

YOL086W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MHF1
locus tag: YOL086W-A
product: Mhf1p
transcript id: NM_001184492.1
SIO_010081: YOL086W-A
subclass of: SO_0000673
so part of: YOL086W-A
location: <159173..>159445
location: region:159173-159445:1
so has part: feature:159173-159445:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159173-159445:1:exon

YOL086W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MHF1
locus tag: YOL086W-A
experiment: EXISTENCE:direct assay:GO:0071821 FANCM-MHF complex [PMID:22325783]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:20347428]
note: Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
codon start: 1
product: Mhf1p
translation: MNDDEDRAQLKARLWIRVEERLQQVLSSEDIKYTPRFINSLLELAYLQLGEMGSDLQAFARHAGRGVVNKSDLMLYLRKQPDLQERVTQE
SIO_010081: YOL086W-A
subclass of: SO_0000673
so part of: YOL086W-A
location: 159173..159445
location: region:159173-159445:1
so has part: feature:159173-159445:1:exon

NP_076910.1
type: Protein
SIO_000068: ncbiprotein

S000007626
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159173-159445:1:exon

YOL086C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ADC1
gene: ADH1
locus tag: YOL086C
gene synonym: ADC1
so part of: sequence
location: complement(<159548..>160594)
location: region:159548-160594:-1
so has part: feature:159548-160594:-1:exon
subclass of: SO_0000010

854068
type: Gene
SIO_000068: ncbigene

position:159548:-1
position: 159548
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:160594:-1
position: 160594
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159548-160594:-1:exon

YOL086C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ADC1
gene: ADH1
locus tag: YOL086C
gene synonym: ADC1
product: alcohol dehydrogenase ADH1
transcript id: NM_001183340.1
SIO_010081: YOL086C
subclass of: SO_0000673
so part of: YOL086C
location: complement(<159548..>160594)
location: region:159548-160594:-1
so has part: feature:159548-160594:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159548-160594:-1:exon

YOL086C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ADC1
gene: ADH1
locus tag: YOL086C
gene synonym: ADC1
EC number: 1.1.1.1
experiment: EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:6985717]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2937632]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006116 NADH oxidation [PMID:3546317]
experiment: EXISTENCE:direct assay:GO:0019170 methylglyoxal reductase (NADH-dependent) activity [PMID:12722185]
experiment: EXISTENCE:direct assay:GO:0045069 regulation of viral genome replication [PMID:31648290]
experiment: EXISTENCE:direct assay:GO:0046809 replication compartment [PMID:31648290]
experiment: EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]
experiment: EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
experiment: EXISTENCE:mutant phenotype:GO:0006116 NADH oxidation [PMID:15082781|PMID:23744286]
experiment: EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:15082781]
note: Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication
codon start: 1
product: alcohol dehydrogenase ADH1
translation: MSIPETQKGVIFYESHGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSFQQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKALKSANLMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGGAHGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRADTREALDFFARGLVKSPIKVVGLSTLPEIYEKMEKGQIVGRYVVDTSK
SIO_010081: YOL086C
subclass of: SO_0000673
so part of: YOL086C
location: complement(159548..160594)
location: region:159548-160594:-1
so has part: feature:159548-160594:-1:exon

NP_014555.1
type: Protein
SIO_000068: ncbiprotein

S000005446
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159548-160594:-1:exon

YOL085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL085C
so part of: sequence
location: complement(<161673..>162014)
location: region:161673-162014:-1
so has part: feature:161673-162014:-1:exon
subclass of: SO_0000010

854069
type: Gene
SIO_000068: ncbigene

position:161673:-1
position: 161673
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:162014:-1
position: 162014
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:161673-162014:-1:exon

YOL085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL085C
product: uncharacterized protein
transcript id: NM_001348875.1
SIO_010081: YOL085C
subclass of: SO_0000673
so part of: YOL085C
location: complement(<161673..>162014)
location: region:161673-162014:-1
so has part: feature:161673-162014:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:161673-162014:-1:exon

YOL085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL085C
note: hypothetical protein; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A
codon start: 1
product: uncharacterized protein
translation: MKAKDKYKGRTKNKVKSVDMMYLALRRRKNEFTQLHNHADSVADPRSCRPGDNAGREAVPGGVFCACIFQGLPCAKGRDWRSNKNAGWGCDDDDHDNWCHYLSCRKNLSAFAT
SIO_010081: YOL085C
subclass of: SO_0000673
so part of: YOL085C
location: complement(161673..162014)
location: region:161673-162014:-1
so has part: feature:161673-162014:-1:exon

NP_001335813.1
type: Protein
SIO_000068: ncbiprotein

S000005445
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:161673-162014:-1:exon

YOL084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHM7
locus tag: YOL084W
so part of: sequence
location: <162356..>165331
location: region:162356-165331:1
so has part: feature:162356-165331:1:exon
subclass of: SO_0000010

854070
type: Gene
SIO_000068: ncbigene

position:162356:1
position: 162356
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:165331:1
position: 165331
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:162356-165331:1:exon

YOL084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHM7
locus tag: YOL084W
product: Phm7p
transcript id: NM_001183338.1
SIO_010081: YOL084W
subclass of: SO_0000673
so part of: YOL084W
location: <162356..>165331
location: region:162356-165331:1
so has part: feature:162356-165331:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:162356-165331:1:exon

YOL084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHM7
locus tag: YOL084W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
codon start: 1
product: Phm7p
translation: MADSSSTSAFISTLIIYGLTAVVFVWLFLLLRPKNRRVYEPRSLKDIQTIPEEERTEPVPEGYFGWVEYLLSKPHSFLIQHTSVDGYFLLRYIGIVGSLSFVGCLLLLPILLPVNATNGNNLQGFELLSFSNVTNKNRFYAHVFLSWIFFGLFTYVIYKELYYYVVFRHAMQTTPLYDGLLSSRTVIVTELHKSIAQEGEMQMRFPKASNVAFAYDLSDLQELCKERAKNAAKYEAALNKVLNKCVKMTRNKTQKQLDKLYNNGTKPKDDLETYVPHKKRPKHRLGKLPLCLGGKKVNTLSYSSKRIGELNEEIHEKQADWASNDRQPACFIQFETQLEAQRCYQSVEAILGKKNFGKRLIGYSPEDVNWGSMRLSSKERHSRRAVANTIMVLLIIFWAFPVAVVGIISNVNFLTDKVPFLRFINNMPTFLMGVITGLLPTIALVVLMSLVPPFIVMLGKLSGCVTRQETDLYSQAWYYAFAVIQIFLVVTATSSASSTVDSIIDRPRSAMTLLANNLPKASNFYIMYFILKGLTGPTWTILQAVNLLLSKVLGRVLDSTPRQKWNRYNTLATPRMGIVYPGIEILVCIYICYSIIAPILLFFSTVMLTLLYVAYLYNLNYVFGFSFDLKGRNYPRALFQIFVGIYLSEVCLLGLFIMAKTWGPLVLEVFWIVVTALAHIYMKRKFIPLFDAVPLSAIRHARGEPGYSYPTSDLGLQEIKDIADEMKGKYEQDNTHGILTPVTKDDLKKANLIPDNDGSSENGTPSNPFESGSERASLSGSNAESDSIKKLNDTVIKKSSTLSSSTKDNNESTFVPEGEKFRKFHYSDVEALRNKRPYDEDDHSKHGPEGAVPVNADAGVIYSDPAAVMKEPQAFPPDVLETNTWTRRILQFFNPRRSYPFDSVRMRFPLVFNTSIEYDEEYLSSAYTDPCVREKDPIVWCCKDPLGVSKQQIQEARSNGLDVRDDFTRYDEKGKVIFTYNPPDYEPEAKK
SIO_010081: YOL084W
subclass of: SO_0000673
so part of: YOL084W
location: 162356..165331
location: region:162356-165331:1
so has part: feature:162356-165331:1:exon

NP_014557.1
type: Protein
SIO_000068: ncbiprotein

S000005444
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:162356-165331:1:exon

YOL083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATG34
locus tag: YOL083W
so part of: sequence
location: <165714..>166952
location: region:165714-166952:1
so has part: feature:165714-166952:1:exon
subclass of: SO_0000010

854071
type: Gene
SIO_000068: ncbigene

position:165714:1
position: 165714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:166952:1
position: 166952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:165714-166952:1:exon

YOL083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATG34
locus tag: YOL083W
product: Atg34p
transcript id: NM_001183337.1
SIO_010081: YOL083W
subclass of: SO_0000673
so part of: YOL083W
location: <165714..>166952
location: region:165714-166952:1
so has part: feature:165714-166952:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:165714-166952:1:exon

YOL083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATG34
locus tag: YOL083W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:20639194|PMID:20659891]
experiment: EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:20639194]
experiment: EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:20639194|PMID:20659891]
experiment: EXISTENCE:genetic interaction:GO:0071211 protein targeting to vacuole involved in autophagy [PMID:20639194]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20639194]
note: Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
codon start: 1
product: Atg34p
translation: MKIAVETTLFDFFVIDQFKKSTFSAPNTKVDTIKGCINKFIEQFNVYDEQHIFWQPPGKSNVRLLSNANDFGQLGNFLHKKIKCNIFIGEEALRKYDLNICGPYDKFVENSDPSVKKVVNRDDVMLSRKCLNIISEQLSILEKSISKAQNQVLQSSEVEGKKCIILPEDKPELIKFFSKFETSVQLQEVYEGYKVYEKLLQKFGGQKKRMESFLNENTPMSGAEAIKQINISEELKEKGERLTTPNDPLLHVEVSNEDNSLHFILYNKTNIIIPGNCTFEFSSQISEVFSIKMGPHEIGIKGQKELWFFPSLPTPLSNYTMKVVNQDGETILVGKCADSNEITLKSPLASFSTGSFQTGSFHTLQDPTNVFRADALSSPDESSIMSTPFLGETDEVYNSGSTLSRPFTWEEI
SIO_010081: YOL083W
subclass of: SO_0000673
so part of: YOL083W
location: 165714..166952
location: region:165714-166952:1
so has part: feature:165714-166952:1:exon

NP_014558.1
type: Protein
SIO_000068: ncbiprotein

S000005443
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:165714-166952:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1510; Autonomously Replicating Sequence
so part of: sequence
location: 166976..167221
location: region:166976-167221:1
so has part: feature:166976-167221:1:region

S000118487
type: SGD
SIO_000068: sgd

position:166976:1
position: 166976
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:167221:1
position: 167221
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:166976-167221:1:region

YOL082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CVT19
gene: ATG19
locus tag: YOL082W
gene synonym: CVT19
so part of: sequence
location: <168727..>169974
location: region:168727-169974:1
so has part: feature:168727-169974:1:exon
subclass of: SO_0000010

854072
type: Gene
SIO_000068: ncbigene

position:168727:1
position: 168727
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169974:1
position: 169974
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168727-169974:1:exon

YOL082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CVT19
gene: ATG19
locus tag: YOL082W
gene synonym: CVT19
product: Atg19p
transcript id: NM_001183336.1
SIO_010081: YOL082W
subclass of: SO_0000673
so part of: YOL082W
location: <168727..>169974
location: region:168727-169974:1
so has part: feature:168727-169974:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:168727-169974:1:exon

YOL082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CVT19
gene: ATG19
locus tag: YOL082W
gene synonym: CVT19
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:12479808|PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11382752]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:11430817|PMID:12479808|PMID:20659891]
experiment: EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:20659891]
experiment: EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:15138258]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:17238920]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:12479808]
experiment: EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:11430817|PMID:12479808|PMID:12479807|PMID:20659891]
experiment: EXISTENCE:mutant phenotype:GO:0061912 selective autophagy [PMID:29673596]
note: Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p
codon start: 1
product: Atg19p
translation: MNNSKTNQQMNTSMGYPLTVYDECNKFQLIVPTLDANIMLWCIGQLSLLNDSNGCKHLFWQPNDKSNVRILLNNYDYGHLFKYLQCQRKCSVYIGEGTLKKYNLTISTSFDNFLDLTPSEEKESLCREDAHEDPVSPKAGSEEEISPNSTSNVVVSRECLDNFMKQLLKLEESLNKLELEQKVTNKEPNHRISGTIDIPEDRSELVNFFTELKTVKQLEDVFQRYHDYERLSQECDSKTEIASDHSKKETKIEVEPPNERSLQITMNQRDNSLYFQLFNNTNSVLAGNCKLKFTDAGDKPTTQIIDMGPHEIGIKEYKEYRYFPYALDLEAGSTIEIENQYGEVIFLGKYGSSPMINLRPPSRLSAESLQASQEPFYSFQIDTLPELDDSSIISTSISLSYDGDDNEKALTWEEL
SIO_010081: YOL082W
subclass of: SO_0000673
so part of: YOL082W
location: 168727..169974
location: region:168727-169974:1
so has part: feature:168727-169974:1:exon

NP_014559.1
type: Protein
SIO_000068: ncbiprotein

S000005442
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:168727-169974:1:exon

YOL081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CCS1
alternative label: GLC4
gene: IRA2
locus tag: YOL081W
gene synonym: CCS1; GLC4
so part of: sequence
location: <171070..>180309
location: region:171070-180309:1
so has part: feature:171070-180309:1:exon
subclass of: SO_0000010

854073
type: Gene
SIO_000068: ncbigene

position:171070:1
position: 171070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:180309:1
position: 180309
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171070-180309:1:exon

YOL081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CCS1
alternative label: GLC4
gene: IRA2
locus tag: YOL081W
gene synonym: CCS1; GLC4
product: Ras GTPase activating protein IRA2
transcript id: NM_001183335.1
SIO_010081: YOL081W
subclass of: SO_0000673
so part of: YOL081W
location: <171070..>180309
location: region:171070-180309:1
so has part: feature:171070-180309:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171070-180309:1:exon

YOL081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CCS1
alternative label: GLC4
gene: IRA2
locus tag: YOL081W
gene synonym: CCS1; GLC4
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:7577970]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22575457|PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:2178777]
experiment: EXISTENCE:mutant phenotype:GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [PMID:15629464|PMID:2164637]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15629464]
experiment: EXISTENCE:mutant phenotype:GO:0043547 positive regulation of GTPase activity [PMID:2178777]
experiment: EXISTENCE:mutant phenotype:GO:0046580 negative regulation of Ras protein signal transduction [PMID:15339905]
experiment: EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:15629464]
experiment: EXISTENCE:mutant phenotype:GO:0070417 cellular response to cold [PMID:15629464]
experiment: EXISTENCE:mutant phenotype:GO:0071248 cellular response to metal ion [PMID:15629464]
note: GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
codon start: 1
product: Ras GTPase activating protein IRA2
translation: MSQPTKNKKKEHGTDSKSSRMTRTLVNHILFERILPILPVESNLSTYSEVEEYSSFISCRSVLINVTVSRDANAMVEGTLELIESLLQGHEIISDKGSSDVIESILIILRLLSDALEYNWQNQESLHYNDISTHVEHDQEQKYRPKLNSILPDYSSTHSNGNKHFFHQSKPQALIPELASKLLESCAKLKFNTRTLQILQNMISHVHGNILTTLSSSILPRHKSYLTRHNHPSHCKMIDSTLGHILRFVAASNPSEYFEFIRKSVQVPVTQTHTHSHSHSHSLPSSVYNSIVPHFDLFSFIYLSKHNFKKYLELIKNLSVTLRKTIYHCLLLHYSAKAIMFWIMARPAEYYELFNLLKDNNNEHSKSLNTLNHTLFEEIHSTFNVNSMITTNQNAHQGSSSPSSSSPSSPPSSSSSDNNNQNIIAKSLSRQLSHHQSYIQQQSERKLHSSWTTNSQSSTSLSSSTSNSTTTDFSTHTQPGEYDPSLPDTPTMSNITISASSLLSQTPTPTTQLQQRLNSAAAAAAAAASPSNSTPTGYTAEQQSRASYDAHKTGHTGKDYDEHFLSVTRLDNVLELYTHFDDTEVLPHTSVLKFLTTLTMFDIDLFNELNATSFKYIPDCTMHRPKERTSSFNNTAHETGSEKTSGIKHITQGLKKLTSLPSSTKKTVKFVKMLLRNLNGNQAVSDVALLDTMRALLSFFTMTSAVFLVDRNLPSVLFAKRLIPIMGTNLSVGQDWNSKINNSLMVCLKKNSTTFVQLQLIFFSSAIQFDHELLLARLSIDTMANNLNMQKLCLYTEGFRIFFDIPSKKELRKAIAVKISKFFKTLFSIIADILLQEFPYFDEQITDIVASILDGTIINEYGTKKHFKGSSPSLCSTTRSRSGSTSQSSMTPVSPLGLDTDICPMNTLSLVGSSTSRNSDNVNSLNSSPKNLSSDPYLSHLVAPRARHALGGPSSIIRNKIPTTLTSPPGTEKSSPVQRPQTESISATPMAITNSTPLSSAAFGIRSPLQKIRTRRYSDESLGKFMKSTNNYIQEHLIPKDLNEATLQDARRIMINIFSIFKRPNSYFIIPHNINSNLQWVSQDFRNIMKPIFVAIVSPDVDLQNTAQSFMDTLLSNVITYGESDENISIEGYHLLCSYTVTLFAMGLFDLKINNEKRQILLDITVKFMKVRSHLAGIAEASHHMEYISDSEKLTFPLIMGTVGRALFVSLYSSQQKIEKTLKIAYTEYLSAINFHERNIDDADKTWVHNIEFVEAMCHDNYTTSGSIAFQRRTRNNILRFATIPNAILLDSMRMIYKKWHTYTHSKSLEKQERNDFRNFAGILASLSGILFINKKILQEMYPYLLDTVSELKKNIDSFISKQCQWLNYPDLLTRENSRDILSVELHPLSFNLLFNNLRLKLKELACSDLSIPENESSYVLLEQIIKMLRTILGRDDDNYVMMLFSTEIVDLIDLLTDEIKKIPAYCPKYLKAIIQMTKMFSALQHSEVNLGVKNHFHVKNKWLRQITDWFQVSIAREYDFENLSKPLKEMDLVKRDMDILYIDTAIEASTAIAYLTRHTFLEIPPAASDPELSRSRSVIFGFYFNILMKGLEKSSDRDNYPVFLRHKMSVLNDNVILSLTNLSNTNVDASLQFTLPMGYSGNRNIRNAFLEVFINIVTNYRTYTAKTDLGKLEAADKFLRYTIEHPQLSSFGAAVCPASDIDAYAAGLINAFETRNATHIVVAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFEIEKLKPEDSDAERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACEKFPDHAIIAAGSFVFLRFFCPALVSPDSENIIDISHLSEKRTFISLAKVIQNIANGSENFSRWPALCSQKDFLKECSDRIFRFLAELCRTDRTIDIQVRTDPTPIAFDYQFLHSFVYLYGLEVRRNVLNEAKHDDGDIDGDDFYKTTFLLIDDVLGQLGQPKMEF…
SIO_010081: YOL081W
subclass of: SO_0000673
so part of: YOL081W
location: 171070..180309
location: region:171070-180309:1
so has part: feature:171070-180309:1:exon

NP_014560.1
type: Protein
SIO_000068: ncbiprotein

S000005441
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171070-180309:1:exon

YOL080C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: REX4
locus tag: YOL080C
so part of: sequence
location: complement(<180558..>181427)
location: region:180558-181427:-1
so has part: feature:180558-181427:-1:exon
subclass of: SO_0000010

854075
type: Gene
SIO_000068: ncbigene

position:180558:-1
position: 180558
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181427:-1
position: 181427
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180558-181427:-1:exon

YOL080C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: REX4
locus tag: YOL080C
product: putative 3'-5' exonuclease
transcript id: NM_001183334.1
SIO_010081: YOL080C
subclass of: SO_0000673
so part of: YOL080C
location: complement(<180558..>181427)
location: region:180558-181427:-1
so has part: feature:180558-181427:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180558-181427:-1:exon

YOL080C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: REX4
locus tag: YOL080C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0000027 ribosomal large subunit assembly [PMID:12364601]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:12364601]
note: Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly
codon start: 1
product: putative 3'-5' exonuclease
translation: MALSSNWQALLASESNPTSNGKNKQSNRKIRNVKKVSKTVNVSSTTQYAPRKRKNGSKIMDMVYNMNKEISKHEKDKLEGKVFEFNPNKANTSTTIKEPVKVGISEDTRINSNKSKEIGKYIAMDCEFVGVGPEGKESALARISIVNYFGHVVLDEFVKPREKVVEWRTWVSGIKPEHMKNAITFKEAQKKTADILEGRILVGHALKHDLEALMLSHPKSLLRDTSRHLPFRKLYAKGKTPSLKKLTREVLKISIQEGEHSSVEDARATMLLYKKEKTEFEKIHRNTFN
SIO_010081: YOL080C
subclass of: SO_0000673
so part of: YOL080C
location: complement(180558..181427)
location: region:180558-181427:-1
so has part: feature:180558-181427:-1:exon

NP_014561.1
type: Protein
SIO_000068: ncbiprotein

S000005440
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180558-181427:-1:exon

YOL078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVO1
locus tag: YOL078W
so part of: sequence
location: <181682..>185212
location: region:181682-185212:1
so has part: feature:181682-185212:1:exon
subclass of: SO_0000010

854076
type: Gene
SIO_000068: ncbigene

position:181682:1
position: 181682
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185212:1
position: 185212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181682-185212:1:exon

YOL078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVO1
locus tag: YOL078W
product: Avo1p
transcript id: NM_001183332.1
SIO_010081: YOL078W
subclass of: SO_0000673
so part of: YOL078W
location: <181682..>185212
location: region:181682-185212:1
so has part: feature:181682-185212:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181682-185212:1:exon

YOL078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVO1
locus tag: YOL078W
experiment: EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:19144819]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19144819]
experiment: EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16002396]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]
note: Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; C-terminal PH domain binds to phosphoinositide-(4,5)-bisphosphate (PI(4,5)P2); binds directly to Ypk2p a Tor2p substrate and downstream TORC2 effector through a conserved central CRIM domain; acts with Tsc11p as a scaffold important for the integrity of the TORC2 complex; dispensable for PM localization of TORC2; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1
codon start: 1
product: Avo1p
translation: MDTVTVLNELRAQFLRVCPEKDQMKRIIKPYIPVDEFNTEQCLDSSIRELYMNSDGVSLLPELESPPVSKDFMENYASLGKMRIMRENEGQKGKANQNLIGAEKTERDEEETRNLQDKSAKNTLIVEENGTLRYNPLNSSASNSLLNDDDHTSGKHHKTSSKEDSYLNSSMEMQKKSSKRSSLPFVRIFKSRRDHSNTSGNKNVMNTTNTRAKSSTLHPPGARHNKKGSKFDMNFDFDENLEEEDDDDDDDEEGDDIHSQFFQLDDDFDAKGSGASPAHKGINGMSNNKNNTYTNNRNSISILDDRESSNGNIGSASRLKSHFPTSQKGKIFLTDNKNDGQKSDSLNANKGIHGDGSSASGNGSVSRDGLTETESNNISDMESYINEKDLDDLNFDTVTSNINKTVSDLGGHESTNDGTAVMNRDSKDSRSNSNEFNAQNRDRITPGSSYGKSLLGSEYSEERYSNNDSSTMESGEMSLDSDMQTNTIPSHSIPMSMQKYGIYHGDDDSTLNNVFDKAVLTMNSSRHPKERRDTVISGKEPTSLTSSNRKFSVSSNLTSTRSPLLRGHGRTSSTASSEHMKAPKVSDSVLHRARKSTLTLKQDHSQPSVPSSVHKSSKEGNILIEKTTDYLVSKPKASQLSNMFNKKKKRTNTNSVDVLEYFSFVCGDKVPNYESMGLEIYIQASKKYKRNSFTTKVRKSSTIFEVIGFALFLYSTEKKPDNFEEDGLTVEDISNPNNFSLKIVDEDGEPFEDNFGKLDRKSTIQSISDSEVVLCKVDDAEKSQNEIETPLPFETGGGLMDASTLDANSSHDTTDGTINQLSFYKPIIGNEDDIDKTNGSKIIDVTVYLYPNVNPKFNYTTISVLVTSHINDILVKYCKMKNMDPNEYALKVLGKNYILDLNDTVLRLDGINKVELISKKDARELHLEKMKPDLKKPVLPTIQSNDLTPLTLEPLNSYLKADAGGAVAAIPENTKVTSKAKKISTKYKLGLAKQHSSSSVASGSVSTAGGLANGNGFFKNKNSSKSSLHGTLQFHNINRSQSTMEHTPDTPNGVGDNFQDLFTGAYHKYKVWRRQQMSFINKHERTLAIDGDYIYIVPPEGRIHWHDNVKTKSLHISQVVLVKKSKRVPEHFKIFVRREGQDDIKRYYFEAVSGQECTEIVTRLQNLLSAYRMNHK
SIO_010081: YOL078W
subclass of: SO_0000673
so part of: YOL078W
location: 181682..185212
location: region:181682-185212:1
so has part: feature:181682-185212:1:exon

NP_014563.1
type: Protein
SIO_000068: ncbiprotein

S000005438
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181682-185212:1:exon

YOL077W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP19
locus tag: YOL077W-A
so part of: sequence
location: <185438..>185644
location: region:185438-185644:1
so has part: feature:185438-185644:1:exon
subclass of: SO_0000010

854077
type: Gene
SIO_000068: ncbigene

position:185438:1
position: 185438
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185644:1
position: 185644
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185438-185644:1:exon

YOL077W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP19
locus tag: YOL077W-A
product: F1F0 ATP synthase subunit k
transcript id: NM_001184377.1
SIO_010081: YOL077W-A
subclass of: SO_0000673
so part of: YOL077W-A
location: <185438..>185644
location: region:185438-185644:1
so has part: feature:185438-185644:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185438-185644:1:exon

YOL077W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP19
locus tag: YOL077W-A
experiment: EXISTENCE:curator inference:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:9857174]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [PMID:9857174]
experiment: EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9857174]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971]
note: Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
codon start: 1
product: F1F0 ATP synthase subunit k
translation: MGAAYHFMGKAIPPHQLAIGTLGLLGLLVVPNPFKSAKPKTVDIKTDNKDEEKFIENYLKKHSEKQDA
SIO_010081: YOL077W-A
subclass of: SO_0000673
so part of: YOL077W-A
location: 185438..185644
location: region:185438-185644:1
so has part: feature:185438-185644:1:exon

NP_014564.1
type: Protein
SIO_000068: ncbiprotein

S000007339
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185438-185644:1:exon

YOL077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRX1
locus tag: YOL077C
so part of: sequence
location: complement(<185848..>186723)
location: region:185848-186723:-1
so has part: feature:185848-186723:-1:exon
subclass of: SO_0000010

854078
type: Gene
SIO_000068: ncbigene

position:185848:-1
position: 185848
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186723:-1
position: 186723
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185848-186723:-1:exon

YOL077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRX1
locus tag: YOL077C
product: ribosome biogenesis protein BRX1
transcript id: NM_001183331.2
SIO_010081: YOL077C
subclass of: SO_0000673
so part of: YOL077C
location: complement(<185848..>186723)
location: region:185848-186723:-1
so has part: feature:185848-186723:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185848-186723:-1:exon

YOL077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRX1
locus tag: YOL077C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11843177]
experiment: EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11843177]
experiment: EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11843177]
experiment: EXISTENCE:mutant phenotype:GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11843177]
note: Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
codon start: 1
product: ribosome biogenesis protein BRX1
translation: MSSIYKALAGKSKDNKSEKKQGNVKQFMNKQRTLLISSRGVNYRHRHLIQDLSGLLPHSRKEPKLDTKKDLQQLNEIAELYNCNNVLFFEARKHQDLYLWLSKPPNGPTIKFYIQNLHTMDELNFTGNCLKGSRPVLSFDQRFESSPHYQLIKELLVHNFGVPPNARKSKPFIDHVMSFSIVDDKIWVRTYEISHSTKNKEEYEDGEEDISLVEIGPRFVMTVILILEGSFGGPKIYENKQYVSPNVVRAQIKQQAAEEAKSRAEAAVERKIKRRENVLAADPLSNDALFK
SIO_010081: YOL077C
subclass of: SO_0000673
so part of: YOL077C
location: complement(185848..186723)
location: region:185848-186723:-1
so has part: feature:185848-186723:-1:exon

NP_014565.2
type: Protein
SIO_000068: ncbiprotein

S000005437
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185848-186723:-1:exon

YOL076W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DEC1
alternative label: NAA25
gene: MDM20
locus tag: YOL076W
gene synonym: DEC1; NAA25
so part of: sequence
location: <187024..>189414
location: region:187024-189414:1
so has part: feature:187024-189414:1:exon
subclass of: SO_0000010

854079
type: Gene
SIO_000068: ncbigene

position:187024:1
position: 187024
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:189414:1
position: 189414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187024-189414:1:exon

YOL076W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DEC1
alternative label: NAA25
gene: MDM20
locus tag: YOL076W
gene synonym: DEC1; NAA25
product: Mdm20p
transcript id: NM_001183330.1
SIO_010081: YOL076W
subclass of: SO_0000673
so part of: YOL076W
location: <187024..>189414
location: region:187024-189414:1
so has part: feature:187024-189414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187024-189414:1:exon

YOL076W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DEC1
alternative label: NAA25
gene: MDM20
locus tag: YOL076W
gene synonym: DEC1; NAA25
experiment: EXISTENCE:direct assay:GO:0031416 NatB complex [PMID:12783868]
experiment: EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:9105043]
experiment: EXISTENCE:genetic interaction:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:12783868]
experiment: EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9105043]
experiment: EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:12783868]
experiment: EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9105043]
experiment: EXISTENCE:mutant phenotype:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:12783868]
experiment: EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]
note: Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
codon start: 1
product: Mdm20p
translation: MSDKIQEEILGLVSRSNFKQCYAKLGQLQKQFPNALYFKILETYVKFKQSPGKFDYNKLLEEPYGLKGTTITGDTRSLEFLHNFFVELGKYDEALHVYERGNFKFPSYELSYHWFMKALEDSNYNQMSKASLQLAKYSDSGNLPKRAYYFWNAISILAVSRFQENTLSDPKKILLSRLARQSLLDLKPFQNVQEIIVYCLVLDELFPQSREISEEIVAITFANFDTSVNLYLKNFILKHTKLLNSPQKLFEVCSKLIEKGLDDYELITNLIDAAYKLSKSKDEVKQWIDENLGDSRNTRLARLKLDIMYTDSVSESSLSYYLSKYHNKPCCSIDLNHYSGHINIDMLKSIMSKYDPEDKDLIHHCNILELGLIGSDSINNYNKFKGTLEKKSVTDYSSCSTFLLEIVKDKCKKTNPELKDVLLCITILENYQAKDPHNFDTMCWLIVLYMYLGLVPDAYFHFINLKIKNVQTDSLDYMIFSRFSTLFPNKQSDFYSKTFHEHNNLYDTSLANLPRYIQVAFERNSYSKILGMLEMRDKLMKSYTRWTKTLENLQFSRLCNDKRGHLLQKLHEDWRSLEMTQSVSFSDNRDFSILDENFAQFLNRGKILEYANLNEESIFLTLIRELIIEALPNGEKTEQISALLKKLPSINLEELLNNNLTEVESASFLIFFEIYENNGKNLHDLISRLMKVPINAKQNWMVSHTYLTKMATLKTLDSLKRIKDKEIQKLIKNSLKELRSCCDDVFKGYSKALVQAYEELKKDECGNLLKELDVKAENVKNIKNSLLGIQKSVRNL
SIO_010081: YOL076W
subclass of: SO_0000673
so part of: YOL076W
location: 187024..189414
location: region:187024-189414:1
so has part: feature:187024-189414:1:exon

NP_014566.1
type: Protein
SIO_000068: ncbiprotein

S000005436
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187024-189414:1:exon

YOL075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL075C
so part of: sequence
location: complement(<189658..>193542)
location: region:189658-193542:-1
so has part: feature:189658-193542:-1:exon
subclass of: SO_0000010

854080
type: Gene
SIO_000068: ncbigene

position:189658:-1
position: 189658
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:193542:-1
position: 193542
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:189658-193542:-1:exon

YOL075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL075C
product: uncharacterized protein
transcript id: NM_001183329.2
SIO_010081: YOL075C
subclass of: SO_0000673
so part of: YOL075C
location: complement(<189658..>193542)
location: region:189658-193542:-1
so has part: feature:189658-193542:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:189658-193542:-1:exon

YOL075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL075C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23658021]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Putative ABC transporter
codon start: 1
product: uncharacterized protein
translation: MSQQENGDVATELIENRLSFSRIPRISLHVRDLSIVASKTNTTLVNTFSMDLPSGSVMAVMGGSGSGKTTLLNVLASKISGGLTHNGSIRYVLEDTGSEPNETEPKRAHLDGQDHPIQKHVIMAYLPQQDVLSPRLTCRETLKFAADLKLNSSERTKKLMVEQLIEELGLKDCADTLVGDNSHRGLSGGEKRRLSIGTQMISNPSIMFLDEPTTGLDAYSAFLVIKTLKKLAKEDGRTFIMSIHQPRSDILFLLDQVCILSKGNVVYCDKMDNTIPYFESIGYHVPQLVNPADYFIDLSSVDSRSDKEEAATQSRLNSLIDHWHDYERTHLQLQAESYISNATEIQIQNMTTRLPFWKQVTVLTRRNFKLNFSDYVTLISTFAEPLIIGTVCGWIYYKPDKSSIGGLRTTTACLYASTILQCYLYLLFDTYRLCEQDIALYDRERAEGSVTPLAFIVARKISLFLSDDFAMTMIFVSITYFMFGLEADARKFFYQFAVVFLCQLSCSGLSMLSVAVSRDFSKASLVGNMTFTVLSMGCGFFVNAKVMPVYVRWIKYIAFTWYSFGTLMSSTFTNSYCTTDNLDECLGNQILEVYGFPRNWITVPAVVLLCWSVGYFVVGAIILYLHKIDITLQNEVKSKQKKIKKKSPTGMKPEIQLLDDVYHQKDLEAEKGKNIHITIKLEDIDLRVIFSAPFSNWKEGNFHHETKEILQSVNAIFKPGMINAIMGPSGSGKSSLLNLISGRLKSSVFAKFDTSGSIMFNDIQVSELMFKNVCSYVSQDDDHLLAALTVKETLKYAAALRLHHLTEAERMERTDNLIRSLGLKHCENNIIGNEFVKGISGGEKRRVTMGVQLLNDPPILLLDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPRSELFKRFGNVLLLAKSGRTAFNGSPDEMIAYFTELGYNCPSFTNVADFFLDLISVNTQNEQNEISSRARVEKILSAWKANMDNESLSPTPISEKQQYSQESFFTEYSEFVRKPANLVLAYIVNVKRQFTTTRRSFDSLMARIAQIPGLGVIFALFFAPVKHNYTSISNRLGLAQESTALYFVGMLGNLACYPTERDYFYEEYNDNVYGIAPFFLAYMTLELPLSALASVLYAVFTVLACGLPRTAGNFFATVYCSFIVTCCGEALGIMTNTFFERPGFVVNCISIILSIGTQMSGLMSLGMSRVLKGFNYLNPVGYTSMIIINFAFPGNLKLTCEDGGKNSDGTCEFANGHDVLVSYGLVRNTQKYLGIIVCVAIIYRLIAFFILKAKLEWIKW
SIO_010081: YOL075C
subclass of: SO_0000673
so part of: YOL075C
location: complement(189658..193542)
location: region:189658-193542:-1
so has part: feature:189658-193542:-1:exon

NP_014567.2
type: Protein
SIO_000068: ncbiprotein

S000005435
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:189658-193542:-1:exon

YOL073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DSC2
locus tag: YOL073C
so part of: sequence
location: complement(<193832..>194800)
location: region:193832-194800:-1
so has part: feature:193832-194800:-1:exon
subclass of: SO_0000010

854081
type: Gene
SIO_000068: ncbigene

position:193832:-1
position: 193832
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194800:-1
position: 194800
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:193832-194800:-1:exon

YOL073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DSC2
locus tag: YOL073C
product: Dsc2p
transcript id: NM_001183328.1
SIO_010081: YOL073C
subclass of: SO_0000673
so part of: YOL073C
location: complement(<193832..>194800)
location: region:193832-194800:-1
so has part: feature:193832-194800:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:193832-194800:-1:exon

YOL073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DSC2
locus tag: YOL073C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]
note: Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2
codon start: 1
product: Dsc2p
translation: MSMEPPVGLTAMPVTKLAMITTLVVPLVASIASYKHIFLLQYDPFLQTYHQYYRLLIFQFCAINESDTVILALIWYLFRHLERLLGSHKYLTLIVLSWAYTTLGIWGLNLIWNAFIGQYKWLQWNNFSTGSLPIVLSLVHFYKEYTPQIYEWNIRLLGPRGGASSHNDNKREDKSAVEWKINDQFLLNGLILLLILNQGFAGILCGFISWMCGIFIDKGLLPGLDHWRIPFVSYFISQGPPTRANVAIAANAATNTAAARATVEAATAATGNGNTGNSGPTSLPLRGSSTTPTNTSSAGDDEPGADEPARPLGVQFLDTFRR
SIO_010081: YOL073C
subclass of: SO_0000673
so part of: YOL073C
location: complement(193832..194800)
location: region:193832-194800:-1
so has part: feature:193832-194800:-1:exon

NP_014568.1
type: Protein
SIO_000068: ncbiprotein

S000005434
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:193832-194800:-1:exon

YOL072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BUD29
gene: THP1
locus tag: YOL072W
gene synonym: BUD29
so part of: sequence
location: <194970..>196337
location: region:194970-196337:1
so has part: feature:194970-196337:1:exon
subclass of: SO_0000010

854082
type: Gene
SIO_000068: ncbigene

position:194970:1
position: 194970
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196337:1
position: 196337
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194970-196337:1:exon

YOL072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BUD29
gene: THP1
locus tag: YOL072W
gene synonym: BUD29
product: Thp1p
transcript id: NM_001183327.1
SIO_010081: YOL072W
subclass of: SO_0000673
so part of: YOL072W
location: <194970..>196337
location: region:194970-196337:1
so has part: feature:194970-196337:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194970-196337:1:exon

YOL072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BUD29
gene: THP1
locus tag: YOL072W
gene synonym: BUD29
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:12702719]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12702719]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11139493]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12206772]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:12411502]
experiment: EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:15311284]
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18003937]
experiment: EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11139493]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:12411502]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:18003937]
note: Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
codon start: 1
product: Thp1p
translation: MDMANQLLDELAHGNFSHLTLNLSQNGREIAILQKQLTGFDDKQLETFVEQHPAMPNDTRFKIMCTSFLNYARDVDPWSAWSSSDLIFEFYQCLINCLINDNAPHIEMLIPVATRETEFIINLAGKLDSFHLQLHTRSHQFLSHISSILSRLFNSIKPPRGNASSTNIPGKQRILLYLVNKLNNIYFRIESPQLCSNIFKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLNLPLTNQAITRNGTRILNYMIPTGLILGKMVKWGPLRPFLSQETIDNWSVLYKHVRYGNIQGVSLWLRQNERHLCARQLLIVLLEKLPMVTYRNLIKTVIKSWTTEWGQNKLPYSLIERVLQLSIGPTFEDPGAQEITIYNGIHSPKNVENVLVTLINLGLLRANCFPQLQLCVVKKTTMIQEIVPPVNERITKMFPAHSHVLW
SIO_010081: YOL072W
subclass of: SO_0000673
so part of: YOL072W
location: 194970..196337
location: region:194970-196337:1
so has part: feature:194970-196337:1:exon

NP_014569.1
type: Protein
SIO_000068: ncbiprotein

S000005433
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194970-196337:1:exon

YOL071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EMI5
gene: SDH5
locus tag: YOL071W
gene synonym: EMI5
so part of: sequence
location: <196507..>196995
location: region:196507-196995:1
so has part: feature:196507-196995:1:exon
subclass of: SO_0000010

854083
type: Gene
SIO_000068: ncbigene

position:196507:1
position: 196507
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196995:1
position: 196995
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196507-196995:1:exon

YOL071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EMI5
gene: SDH5
locus tag: YOL071W
gene synonym: EMI5
product: succinate dehydrogenase assembly factor SDH5
transcript id: NM_001183326.1
SIO_010081: YOL071W
subclass of: SO_0000673
so part of: YOL071W
location: <196507..>196995
location: region:196507-196995:1
so has part: feature:196507-196995:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196507-196995:1:exon

YOL071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EMI5
gene: SDH5
locus tag: YOL071W
gene synonym: EMI5
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:19628817]
experiment: EXISTENCE:direct assay:GO:0017013 protein flavinylation [PMID:19628817]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]
experiment: EXISTENCE:mutant phenotype:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:23043141]
experiment: EXISTENCE:physical interaction:GO:0006099 tricarboxylic acid cycle [PMID:19628817]
note: Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
codon start: 1
product: succinate dehydrogenase assembly factor SDH5
translation: MHNMFPALTKTLSLQGYKIINSQTGSAAWSCGRRWFSSDKDDHDDVVTRIKIAPIKRTNEPLDKKRARLIYQSRKRGILETDLLLSGFAAKYLKKMNEEELEEYDSLLNELDWDIYYWATKNFKTSPLPDKWANSKLLKQLQEFSENKEKEILSMPDLSKYQ
SIO_010081: YOL071W
subclass of: SO_0000673
so part of: YOL071W
location: 196507..196995
location: region:196507-196995:1
so has part: feature:196507-196995:1:exon

NP_014570.1
type: Protein
SIO_000068: ncbiprotein

S000005432
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196507-196995:1:exon

YOL070C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NBA1
locus tag: YOL070C
so part of: sequence
location: complement(<197220..>198725)
location: region:197220-198725:-1
so has part: feature:197220-198725:-1:exon
subclass of: SO_0000010

854084
type: Gene
SIO_000068: ncbigene

position:197220:-1
position: 197220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:198725:-1
position: 198725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:197220-198725:-1:exon

YOL070C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NBA1
locus tag: YOL070C
product: Nba1p
transcript id: NM_001183325.1
SIO_010081: YOL070C
subclass of: SO_0000673
so part of: YOL070C
location: complement(<197220..>198725)
location: region:197220-198725:-1
so has part: feature:197220-198725:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:197220-198725:-1:exon

YOL070C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NBA1
locus tag: YOL070C
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:25416945|PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18086883|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:18086883|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]
experiment: EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]
experiment: EXISTENCE:genetic interaction:GO:2001107 negative regulation of Rho guanyl-nucleotide exchange factor activity [PMID:25416945]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]
experiment: EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:29074565]
experiment: EXISTENCE:mutant phenotype:GO:1901900 regulation of protein localization to cell division site [PMID:28148650]
note: Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited by Aim44p and Nap1p to the cell cortex and to cytokinesis remnants (bud scars) where it prevents Rsr1p-mediated activation of Cdc24p, the Cdc42p GEF; localizes to the cytoplasm, and the cell division site prior to being stably recruited to cytokinesis remnants; establishes the transient localization of Rga1p, a Cdc42p GAP, at bud scars along with Nis1p; potential Cdc28p substrate
codon start: 1
product: Nba1p
translation: MSEEREENGISRATLNTQRLSAMIDSLNNEKDDRLFPSPTTTRTMITEEKADQSDVFKPPSRLLRSPAGDVSLPPGDNRSSMISNYSGIIQEGVEVSYVVKNRQQTQERRTSKDSNSLYSLKEPVSKNELPSLPMLPSEATLTKHLSDNQSTKSNTNADEIVIKPVTNAKPVGRFNSNTSKKVEGRGSLKLLSSPLRQEKVMRSSIGSGNLASESGSSTYNTKFHQSIQEQLEEEEEGNVSDKLSIVSSVIPELYTTTNEAPKAINPIRSETNDYNPTIPPRSKDRPRSRLFIEEGDGEGDLLTEEILPTPVQPGGHYKNSSQISTVSEQKSESYYSAATSMPPEEETYLTRPLPSTPNEDSRVTSNLKRDDTLKAIHDRANHTSTSTNKQDDDMYEDIIEETPKKTKLKKDTKKKLNKKKSVKELRSFDIDTLNQLLSVTKGTLIGSEFAQLGMKIEEKRALERLVDSLSRLTADMVLDPDRYEEGLKRLDKATKALEGF
SIO_010081: YOL070C
subclass of: SO_0000673
so part of: YOL070C
location: complement(197220..198725)
location: region:197220-198725:-1
so has part: feature:197220-198725:-1:exon

NP_014571.1
type: Protein
SIO_000068: ncbiprotein

S000005431
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:197220-198725:-1:exon

YOL069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUF2
locus tag: YOL069W
so part of: sequence
location: <198942..>200297
location: region:198942-200297:1
so has part: feature:198942-200297:1:exon
subclass of: SO_0000010

854085
type: Gene
SIO_000068: ncbigene

position:198942:1
position: 198942
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:200297:1
position: 200297
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198942-200297:1:exon

YOL069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUF2
locus tag: YOL069W
product: kinetochore-associated Ndc80 complex subunit NUF2
transcript id: NM_001183324.1
SIO_010081: YOL069W
subclass of: SO_0000673
so part of: YOL069W
location: <198942..>200297
location: region:198942-200297:1
so has part: feature:198942-200297:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198942-200297:1:exon

YOL069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUF2
locus tag: YOL069W
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11179222|PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:11266451]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:8188751]
experiment: EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11266451]
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:17195848]
experiment: EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11266451]
experiment: EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:11266451]
experiment: EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]
experiment: EXISTENCE:physical interaction:GO:0031262 Ndc80 complex [PMID:11179222]
note: Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p
codon start: 1
product: kinetochore-associated Ndc80 complex subunit NUF2
translation: MSRNQDVFPILDLQELVICLQSCDFALATQENISRPTSDYMVTLYKQIIENFMGISVESLLNSSNQETGDGHLQEENENIYLDTLNVLVLNKICFKFFENIGVQDFNMTDLYKPEAQRTQRLLSAVVNYARFREERMFDCNSFILQMESLLGQLRSKFDDYNLIQQQLKQYEDVDGDNIPDEQELQKLEEQNKELEIQLKKLTKIQETLSIDYNDYKISKQSIFKDLEALSFQIVELESNRDKLIKISNTDMEELSEGIKELNDLLIQRKKTLDDLTAQQKNLQDTVTTFETIISELYDVLRIISSEVQESNRTETELVGLKQNLINNKLKLMNVLETGIMYKLEILQEQLDLQLKNLEKLSQDTKEESRLNDTKLMDLQIKYENEIKPKIDKTDIFIQEELISGKINKLNDEIKQLQKDFEVEVKEIEIEYSLLSGHINKYMNEMLEYMQ
SIO_010081: YOL069W
subclass of: SO_0000673
so part of: YOL069W
location: 198942..200297
location: region:198942-200297:1
so has part: feature:198942-200297:1:exon

NP_014572.1
type: Protein
SIO_000068: ncbiprotein

S000005430
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198942-200297:1:exon

YOL068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HST1
locus tag: YOL068C
so part of: sequence
location: complement(<200368..>201879)
location: region:200368-201879:-1
so has part: feature:200368-201879:-1:exon
subclass of: SO_0000010

854086
type: Gene
SIO_000068: ncbigene

position:200368:-1
position: 200368
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201879:-1
position: 201879
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:200368-201879:-1:exon

YOL068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HST1
locus tag: YOL068C
product: histone deacetylase HST1
transcript id: NM_001183323.1
SIO_010081: YOL068C
subclass of: SO_0000673
so part of: YOL068C
location: complement(<200368..>201879)
location: region:200368-201879:-1
so has part: feature:200368-201879:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:200368-201879:-1:exon

YOL068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HST1
locus tag: YOL068C
EC number: 2.3.1.286
experiment: EXISTENCE:direct assay:GO:0017136 NAD-dependent histone deacetylase activity [PMID:11313477|PMID:11711434]
experiment: EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11313477|PMID:27185881]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11313477]
experiment: EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]
note: NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication
codon start: 1
product: histone deacetylase HST1
translation: MNILLMQRIVSFILVVSQGRYFHVGELTMTMLKRPQEEESDNNATKKLKTRLTYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNITSNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRLRLPNFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVTHAEFDLNLLGFCDDVASLVAKKCHWDIPHKKWQDLKKIDYNCTEIDKGTYKIKKQPRKKQQ
SIO_010081: YOL068C
subclass of: SO_0000673
so part of: YOL068C
location: complement(200368..201879)
location: region:200368-201879:-1
so has part: feature:200368-201879:-1:exon

NP_014573.1
type: Protein
SIO_000068: ncbiprotein

S000005429
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:200368-201879:-1:exon

YOL067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTG1
locus tag: YOL067C
so part of: sequence
location: complement(<201985..>202518)
location: region:201985-202518:-1
so has part: feature:201985-202518:-1:exon
subclass of: SO_0000010

854087
type: Gene
SIO_000068: ncbigene

position:201985:-1
position: 201985
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:202518:-1
position: 202518
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:201985-202518:-1:exon

YOL067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTG1
locus tag: YOL067C
product: Rtg1p
transcript id: NM_001183322.1
SIO_010081: YOL067C
subclass of: SO_0000673
so part of: YOL067C
location: complement(<201985..>202518)
location: region:201985-202518:-1
so has part: feature:201985-202518:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:201985-202518:-1:exon

YOL067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTG1
locus tag: YOL067C
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:7493987|PMID:8422683]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10848632]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10848632]
experiment: EXISTENCE:direct assay:GO:0031930 mitochondria-nucleus signaling pathway [PMID:7493987]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8422683|PMID:7493987]
experiment: EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:8422683]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12393187|PMID:8422683]
experiment: EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:12393187]
note: Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization
codon start: 1
product: Rtg1p
translation: MSSIPAGTDPGSCGANFKNDRKRRDKINDRIQELLSIIPKDFFRDYYGNSGSNDTLSESTPGALGLSSKAKGTGTKDGKPNKGQILTQAVEYISHLQNQVDTQNREEVELMVKATQLAKQTGTIVNDINLENTSAEVALSRIGVGPLAATNDDSVRPPAKRLSSFEYGGYGEYGNGS
SIO_010081: YOL067C
subclass of: SO_0000673
so part of: YOL067C
location: complement(201985..202518)
location: region:201985-202518:-1
so has part: feature:201985-202518:-1:exon

NP_014574.1
type: Protein
SIO_000068: ncbiprotein

S000005428
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:201985-202518:-1:exon

YOL066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PUS8
gene: RIB2
locus tag: YOL066C
gene synonym: PUS8
so part of: sequence
location: complement(<202696..>204471)
location: region:202696-204471:-1
so has part: feature:202696-204471:-1:exon
subclass of: SO_0000010

854088
type: Gene
SIO_000068: ncbigene

position:202696:-1
position: 202696
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204471:-1
position: 204471
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202696-204471:-1:exon

YOL066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PUS8
gene: RIB2
locus tag: YOL066C
gene synonym: PUS8
product: bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2
transcript id: NM_001183321.1
SIO_010081: YOL066C
subclass of: SO_0000673
so part of: YOL066C
location: complement(<202696..>204471)
location: region:202696-204471:-1
so has part: feature:202696-204471:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:202696-204471:-1:exon

YOL066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PUS8
gene: RIB2
locus tag: YOL066C
gene synonym: PUS8
EC number: 3.5.4.26
EC number: 5.4.99.28
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15466869]
experiment: EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:5366000|PMID:4555411]
experiment: EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]
experiment: EXISTENCE:mutant phenotype:GO:0043723 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity [PMID:4555411]
note: Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication
codon start: 1
product: bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2
translation: MEDSNNEASDDFNNLLNKEIESAKEVKLRKFANRNNNRNENSSKVKDASGFRLRVIQTDGHKTKKTDPDYEVTIDGPLRKIEPYFFTYKTFCKERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLNDEPANLDTIIRDGDLITHKVHRHEPPVTSKPIDIVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGYSVHPCNRLDKPTSGLMFLAKTPLGADRMGDQMKAREVTKEYVARVKGEFPIGIVEVDKPVRSVNPKVALNAVCEMSDENAKHAKTVFQRVSYDGQTSIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPDIWGPDLGRGGLQNYDDIVLKLDAIGKTNPAESWIHPHSEGEYLLGRQCEECEAEMYTDPGTNDLDLWLHAFRYESLERNSDTQKPLWSYRTKYPEWALEPHRRYMEMAVKEAGKCGPTKTAFSVGAVLVHGTQVLATGYSRELPGNTHAEQCALIKYSQLHPNCPTIVPMGTVLYTTMEPCSFRLSGNEPCCDRILATQGAIGTVFVGVMEPDTFVKNNTSLNKLESHGVNYIQIPGYEEECTIIAFKGHDNSDDKA
SIO_010081: YOL066C
subclass of: SO_0000673
so part of: YOL066C
location: complement(202696..204471)
location: region:202696-204471:-1
so has part: feature:202696-204471:-1:exon

NP_014575.1
type: Protein
SIO_000068: ncbiprotein

S000005427
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202696-204471:-1:exon

YOL065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INP54
locus tag: YOL065C
so part of: sequence
location: complement(<204731..>205885)
location: region:204731-205885:-1
so has part: feature:204731-205885:-1:exon
subclass of: SO_0000010

854089
type: Gene
SIO_000068: ncbigene

position:204731:-1
position: 204731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:205885:-1
position: 205885
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204731-205885:-1:exon

YOL065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INP54
locus tag: YOL065C
product: phosphoinositide 5-phosphatase INP54
transcript id: NM_001183320.1
SIO_010081: YOL065C
subclass of: SO_0000673
so part of: YOL065C
location: complement(<204731..>205885)
location: region:204731-205885:-1
so has part: feature:204731-205885:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:204731-205885:-1:exon

YOL065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INP54
locus tag: YOL065C
EC number: 3.1.3.36
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10660045]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11116155]
experiment: EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10660045]
note: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
codon start: 1
product: phosphoinositide 5-phosphatase INP54
translation: MNKTNWKVSVTTFNCGKEFPVENSKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAVNRDLIDRITTTAVNCLNEKVSATQGDEQYSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVCDSEVAKSDHFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDEPLCKGFQELKITFPPTYKFKLFEKETYNTKRIPSWCDRILYKSYAVPTFAQEGTYHSVPRSNALLFSDHQPVNLTVRLPRSTGTPVPLSLHIEKYPLSWSSGLIGQIGDAVIGYCGWLVTKNVHYWILGSLLLYLLLKIL
SIO_010081: YOL065C
subclass of: SO_0000673
so part of: YOL065C
location: complement(204731..205885)
location: region:204731-205885:-1
so has part: feature:204731-205885:-1:exon

NP_014576.1
type: Protein
SIO_000068: ncbiprotein

S000005426
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:204731-205885:-1:exon

YOL064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HAL2
gene: MET22
locus tag: YOL064C
gene synonym: HAL2
so part of: sequence
location: complement(<206103..>207176)
location: region:206103-207176:-1
so has part: feature:206103-207176:-1:exon
subclass of: SO_0000010

854090
type: Gene
SIO_000068: ncbigene

position:206103:-1
position: 206103
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:207176:-1
position: 207176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:206103-207176:-1:exon

YOL064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HAL2
gene: MET22
locus tag: YOL064C
gene synonym: HAL2
product: 3'(2'),5'-bisphosphate nucleotidase
transcript id: NM_001183319.1
SIO_010081: YOL064C
subclass of: SO_0000673
so part of: YOL064C
location: complement(<206103..>207176)
location: region:206103-207176:-1
so has part: feature:206103-207176:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:206103-207176:-1:exon

YOL064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HAL2
gene: MET22
locus tag: YOL064C
gene synonym: HAL2
EC number: 3.1.3.7
experiment: EXISTENCE:direct assay:GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity [PMID:7809627]
experiment: EXISTENCE:direct assay:GO:0016078 tRNA catabolic process [PMID:31619505]
experiment: EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:8910555]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:8393782]
experiment: EXISTENCE:mutant phenotype:GO:0042538 hyperosmotic salinity response [PMID:8393782]
note: Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant
codon start: 1
product: 3'(2'),5'-bisphosphate nucleotidase
translation: MALERELLVATQAVRKASLLTKRIQSEVISHKDSTTITKNDNSPVTTGDYAAQTIIINAIKSNFPDDKVVGEESSSGLSDAFVSGILNEIKANDEVYNKNYKKDDFLFTNDQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKGFLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLKGHESFGYIFRAVRGLGAFYSPSSDAESWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKSLHLDSQAKYCLLALGLADVYLRLPIKLSYQEKIWDHAAGNVIVHEAGGIHTDAMEDVPLDFGNGRTLATKGVIASSGPRELHDLVVSTSCDVIQSRNA
SIO_010081: YOL064C
subclass of: SO_0000673
so part of: YOL064C
location: complement(206103..207176)
location: region:206103-207176:-1
so has part: feature:206103-207176:-1:exon

NP_014577.1
type: Protein
SIO_000068: ncbiprotein

S000005425
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:206103-207176:-1:exon

YOL063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRT10
locus tag: YOL063C
so part of: sequence
location: complement(<207392..>210265)
location: region:207392-210265:-1
so has part: feature:207392-210265:-1:exon
subclass of: SO_0000010

854091
type: Gene
SIO_000068: ncbigene

position:207392:-1
position: 207392
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210265:-1
position: 210265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:207392-210265:-1:exon

YOL063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRT10
locus tag: YOL063C
product: Crt10p
transcript id: NM_001183318.1
SIO_010081: YOL063C
subclass of: SO_0000673
so part of: YOL063C
location: complement(<207392..>210265)
location: region:207392-210265:-1
so has part: feature:207392-210265:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:207392-210265:-1:exon

YOL063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRT10
locus tag: YOL063C
experiment: EXISTENCE:genetic interaction:GO:0070651 nonfunctional rRNA decay [PMID:25534857]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:25534857]
note: Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat
codon start: 1
product: Crt10p
translation: MPPQIPNENDDLFTRWLKSRAIIQRAVSTRECFDSEVFLASGGWNITNEIITLKKYYQLKWPNSSCNSFHPKTVEFIKERLHNLEEHDSSWKIPNPAYSFKKAFLEDTKSAFSNLEPVWGPSRLLNPAELLLPQDEKLLVQEIPLEFAPFQYTNRFAYGGLQFKNNLFVTYGSYSFLAAGQCVEVHNFDILLNVSSLEICHALLPVIIPDDGDVRNFRNSSYVKFKDTQFNSIPELCSINFMKICNFMHQDFLLACGDNGIVYIWEINKVIKIFNKFTSDILGGKDNSRERYINVDPYMVLRVEESCWSVDVIDINGIIYIAVGHNKPGVTVFAFDKDVKKERRYIRPLDLPSSHNVPCVNFVPNSKDSVGYITLSYCSIFGNVVTVKLKEHDCTILTSFLDTQFFGDDLWTITPLTKKDFAKVDNFELLNLNYQDGFKESMLYSICRDDFLLGYYCDNAYLSGNFGIGTLLNQFQVPVTDLRLTSSAGIPDEVIPLRFTSFDRNYTTTGSIKYEYSREDFALILHAGDLDDMNDAVTKNTSCEQHLHQWTFWEDSGYKHYRATERGFSKYKDIINTFPQLITPSGRNKTSQYQNTSGRKICEPSTYKLTDLENDIEDISREFNRSIRNLKMDKQRQLRTSKEFKSLSSVNHIPNIESGNFLWYNTDAAADWRTLFGKDLNTVLKDPEICSLQLNSTEEDDVNSDPENEESGSSLTSFQRRYRDTEQRAHLKSESQKSWGFHNYVRNVKRLLESAVPGSEDSPLGYQLSEMHDEFFFLTTAHRLVLMKANPLIIISATHHEIFPLDGVVTCASKSLLQALNRINFVCHIKELNCIAVASQLGLISLLRLTEYRGIYSFRQEYILGWEVQDPVNPSPECRCNRNLFDAPMYGADGESSDTYCGVCDVYFPMGDICGLDYTYASDSEELKRKGYATLYVASRGSLRAFKITTEHGTTQQ
SIO_010081: YOL063C
subclass of: SO_0000673
so part of: YOL063C
location: complement(207392..210265)
location: region:207392-210265:-1
so has part: feature:207392-210265:-1:exon

NP_014578.1
type: Protein
SIO_000068: ncbiprotein

S000005424
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:207392-210265:-1:exon

YOL062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AMP1
gene: APM4
locus tag: YOL062C
gene synonym: AMP1
so part of: sequence
location: complement(<210520..>211995)
location: region:210520-211995:-1
so has part: feature:210520-211995:-1:exon
subclass of: SO_0000010

854092
type: Gene
SIO_000068: ncbigene

position:210520:-1
position: 210520
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:211995:-1
position: 211995
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210520-211995:-1:exon

YOL062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AMP1
gene: APM4
locus tag: YOL062C
gene synonym: AMP1
product: Apm4p
transcript id: NM_001183317.1
SIO_010081: YOL062C
subclass of: SO_0000673
so part of: YOL062C
location: complement(<210520..>211995)
location: region:210520-211995:-1
so has part: feature:210520-211995:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210520-211995:-1:exon

YOL062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AMP1
gene: APM4
locus tag: YOL062C
gene synonym: AMP1
experiment: EXISTENCE:curator inference:GO:0006886 intracellular protein transport [PMID:10564262]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:24460703]
experiment: EXISTENCE:physical interaction:GO:0030122 AP-2 adaptor complex [PMID:10564262]
note: Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals
codon start: 1
product: Apm4p
translation: MISGVLVYSSRGELVLNKFFKNSLKRSISDIFRVQVINNLDVRSPVLTLGSTTFHHIRSRHGDNLWLVTITRSNANSAAIWEFLYKLDAVMNAYRLDREEALKEEFMIVHEMLDIMLGGNGIPIDTELNSVIAQMSVKPVRNMGGLLDSPDGNDVLSSSSSPTSSAGELHFPKFLTKRSSSFLGQGDSTSDFYDNNKITWRPKGIIHKKDEVFLYVNERINILVSRDGSILKSYVDGTIDITTHLSGTPICRFGLNDSLGMQSEDEKKWLAQQQRHSGSDFGNKNFIPKAAAGSVLLEDCKFHECVSLDKFNRNHIIEFVPPDGSMELMKYHVRDNINLPFKVTPIVTHSTRDNEIDYRITLKSLFPGKLSAKDVVLHIPVPPSTVDCKISVSNGHCKFVPEENAMIWRFNKYNGLTENTLSAVTVSTSDTTQLNLQQWTRPPISLEFEVMMFSNSGLVVRYFTISGKDSKHRAVKWIKYISKAGSYEVRY
SIO_010081: YOL062C
subclass of: SO_0000673
so part of: YOL062C
location: complement(210520..211995)
location: region:210520-211995:-1
so has part: feature:210520-211995:-1:exon

NP_014579.1
type: Protein
SIO_000068: ncbiprotein

S000005423
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210520-211995:-1:exon

YOL061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRS5
locus tag: YOL061W
so part of: sequence
location: <212244..>213734
location: region:212244-213734:1
so has part: feature:212244-213734:1:exon
subclass of: SO_0000010

854093
type: Gene
SIO_000068: ncbigene

position:212244:1
position: 212244
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:213734:1
position: 213734
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212244-213734:1:exon

YOL061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRS5
locus tag: YOL061W
product: ribose phosphate diphosphokinase subunit PRS5
transcript id: NM_001183316.1
SIO_010081: YOL061W
subclass of: SO_0000673
so part of: YOL061W
location: <212244..>213734
location: region:212244-213734:1
so has part: feature:212244-213734:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212244-213734:1:exon

YOL061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRS5
locus tag: YOL061W
EC number: 2.7.6.1
experiment: EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]
experiment: EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]
experiment: EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]
experiment: EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:15470112]
note: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: ribose phosphate diphosphokinase subunit PRS5
translation: MSMSNIVVFGGDSHPELVTKICENLDIHPSKVELGKFSNGETNIALRESVREKDVYIIQSGCGQVNDTFMQLLILISACKSASASRVTAVMPYLCYSRQPDIPYTAKGAPIISKPKENYTFESHPGTPVSSSLMTQRPGAESSLKSLDSAIRSTINLENPQPIRTPNSSATANNNFDIKKTLSFSRIPMIPGGKLQNTSNSTDAGELFNAQNAGYKLWVVQAGTLIAHLLSAAGADHVITMDLHDPQFPGFFDIPVDNLYCKPIAQNYIQHRIPDYQDAVIVSPDAGGAKRATAIADALELSFALIHKERRSQLLKGPPDATLTSGGSLPVSPRPLVTTLVSSQNTTSSGATGVAALEMKKTTSTSSTSSQSSNSSKFVQTTMLVGDVRNKVCIIVDDLVDTSYTITRAAKLLKDQGSTKVYALITHGVFSGDALERIGQSSIDKLIISNTVPQDRTLQYLGKDRVDVIDVSCIIGEAIRRIHNGESISMLFEHGW
SIO_010081: YOL061W
subclass of: SO_0000673
so part of: YOL061W
location: 212244..213734
location: region:212244-213734:1
so has part: feature:212244-213734:1:exon

NP_014580.1
type: Protein
SIO_000068: ncbiprotein

S000005422
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212244-213734:1:exon

YOL060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAM3
locus tag: YOL060C
so part of: sequence
location: complement(<214017..>216137)
location: region:214017-216137:-1
so has part: feature:214017-216137:-1:exon
subclass of: SO_0000010

854094
type: Gene
SIO_000068: ncbigene

position:214017:-1
position: 214017
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:216137:-1
position: 216137
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214017-216137:-1:exon

YOL060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAM3
locus tag: YOL060C
product: Mam3p
transcript id: NM_001183315.1
SIO_010081: YOL060C
subclass of: SO_0000673
so part of: YOL060C
location: complement(<214017..>216137)
location: region:214017-216137:-1
so has part: feature:214017-216137:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214017-216137:-1:exon

YOL060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAM3
locus tag: YOL060C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10628851]
experiment: EXISTENCE:mutant phenotype:GO:0010961 cellular magnesium ion homeostasis [PMID:35087208]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:15498024]
note: Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins
codon start: 1
product: Mam3p
translation: MSFLPLRSRSRSGAPHWVYIILYHIFTIPKIYSLPLLSGSHVLNSRDVADSGHSVGDEASVTTYYIISIILVLLGGVFAGLTLGLMGQDEVYLKVISTSGSNSEKKLAKRVLDLISRGKHWVLVTLLLSNVITNETLPIVLDRCLGGGWQAVVSSTILIVIFGEIIPQSVCVKYGLQVGAFFCPFVLVLMYLMYPVAYPIATLLDYMLGEDHGTMYKKSGLKTLVTLHRTMGVERLTKDEVTIISAVLDLKAKRVEEIMTPIENVFTMSADTILDDKTVEKIFNSGFSRIPIFLPNEPNNFIGMLLVRVLISYDPDDCLPISHFPLATLPETSPNTSCLNILNYFQEGKAHMCVVSKEPGSSHGAIGVLTLEDVIEELIGEEIVDESDVFVDMHQHIMRQQPGPLSKRHITSYLHHLYTSSHKEHKAADQADESSPLLSPSNSNHPSEHPQQDLNNKSWKQKSNDGYDRSNAVLSPTPQVTEHGTIIPSNLASNPLNVNKSFVTIKKPANVPKIITTHTPHSSKEPSPAPHSNDKSLSAEEQQLLSDHAELSRQAVLHTQRSGQPTQVTTSTKTTRNSPDSISIPNSGANHGNENQNVTISTSYQNTKNGIVESVITVKGVPKTIIGPAKDWDESKSEYGNENINQENSNRSDDRESSSSNASLFSSIKNKFKNENANNNDRSNFTDSLSRTSNYDANGSSSTIKR
SIO_010081: YOL060C
subclass of: SO_0000673
so part of: YOL060C
location: complement(214017..216137)
location: region:214017-216137:-1
so has part: feature:214017-216137:-1:exon

NP_014581.1
type: Protein
SIO_000068: ncbiprotein

S000005421
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214017-216137:-1:exon

YOL059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GPD3
gene: GPD2
locus tag: YOL059W
gene synonym: GPD3
so part of: sequence
location: <217126..>218448
location: region:217126-218448:1
so has part: feature:217126-218448:1:exon
subclass of: SO_0000010

854095
type: Gene
SIO_000068: ncbigene

position:217126:1
position: 217126
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218448:1
position: 218448
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217126-218448:1:exon

YOL059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GPD3
gene: GPD2
locus tag: YOL059W
gene synonym: GPD3
product: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
transcript id: NM_001183314.1
SIO_010081: YOL059W
subclass of: SO_0000673
so part of: YOL059W
location: <217126..>218448
location: region:217126-218448:1
so has part: feature:217126-218448:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217126-218448:1:exon

YOL059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GPD3
gene: GPD2
locus tag: YOL059W
gene synonym: GPD3
EC number: 1.1.1.8
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:9171333]
experiment: EXISTENCE:mutant phenotype:GO:0006116 NADH oxidation [PMID:9171333]
experiment: EXISTENCE:mutant phenotype:GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [PMID:9171333]
note: NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication
codon start: 1
product: glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2
translation: MLAVRRLTRYTFLKRTHPVLYTRRAYKILPSRSTFLRRSLLQTQLHSKMTAHTNIKQHKHCHEDHPIRRSDSAVSIVHLKRAPFKVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSIKGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSETTVAYQLPKDYQGDGKDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGEIIKFGRMFFPESKVETYYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCELTQEFPLFEAVYQIVYNNVRMEDLPEMIEELDIDDE
SIO_010081: YOL059W
subclass of: SO_0000673
so part of: YOL059W
location: 217126..218448
location: region:217126-218448:1
so has part: feature:217126-218448:1:exon

NP_014582.1
type: Protein
SIO_000068: ncbiprotein

S000005420
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217126-218448:1:exon

YOL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARG10
gene: ARG1
locus tag: YOL058W
gene synonym: ARG10
so part of: sequence
location: <219211..>220473
location: region:219211-220473:1
so has part: feature:219211-220473:1:exon
subclass of: SO_0000010

854096
type: Gene
SIO_000068: ncbigene

position:219211:1
position: 219211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220473:1
position: 220473
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:219211-220473:1:exon

YOL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARG10
gene: ARG1
locus tag: YOL058W
gene synonym: ARG10
product: argininosuccinate synthase
transcript id: NM_001183313.2
SIO_010081: YOL058W
subclass of: SO_0000673
so part of: YOL058W
location: <219211..>220473
location: region:219211-220473:1
so has part: feature:219211-220473:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:219211-220473:1:exon

YOL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARG10
gene: ARG1
locus tag: YOL058W
gene synonym: ARG10
EC number: 6.3.4.5
experiment: EXISTENCE:direct assay:GO:0004055 argininosuccinate synthase activity [PMID:2897249]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]
experiment: EXISTENCE:mutant phenotype:GO:0006526 arginine biosynthetic process [PMID:2897249]
note: Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
codon start: 1
product: argininosuccinate synthase
translation: MSKGKVCLAYSGGLDTSVILAWLLDQGYEVVAFMANVGQEEDFDAAKEKALKIGACKFVCVDCREDFVKDILFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGNDQIRFELSFYALKPDVKCITPWRMPEFFERFAGRKDLLDYAAQKGIPVAQTKAKPWSTDENQAHISYEAGILEDPDTTPPKDMWKLIVDPMDAPDQPQDLTIDFERGLPVKLTYTDNKTSKEVSVTKPLDVFLAASNLARANGVGRIDIVEDRYINLKSRGCYEQAPLTVLRKAHVDLEGLTLDKEVRQLRDSFVTPNYSRLIYNGSYFTPECEYIRSMIQPSQNSVNGTVRVRLYKGNVIILGRSTKTEKLYDPTESSMDELTGFLPTDTTGFIAIQAIRIKKYGESKKTKGEELTL
SIO_010081: YOL058W
subclass of: SO_0000673
so part of: YOL058W
location: 219211..220473
location: region:219211-220473:1
so has part: feature:219211-220473:1:exon

NP_014583.2
type: Protein
SIO_000068: ncbiprotein

S000005419
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:219211-220473:1:exon

YOL057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL057W
so part of: sequence
location: <220767..>222902
location: region:220767-222902:1
so has part: feature:220767-222902:1:exon
subclass of: SO_0000010

854097
type: Gene
SIO_000068: ncbigene

position:220767:1
position: 220767
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222902:1
position: 222902
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220767-222902:1:exon

YOL057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL057W
product: dipeptidyl-peptidase III
transcript id: NM_001183312.1
SIO_010081: YOL057W
subclass of: SO_0000673
so part of: YOL057W
location: <220767..>222902
location: region:220767-222902:1
so has part: feature:220767-222902:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220767-222902:1:exon

YOL057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL057W
EC number: 3.4.14.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008239 dipeptidyl-peptidase activity [PMID:19825391]
note: Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
codon start: 1
product: dipeptidyl-peptidase III
translation: MSHFFADHDAPLSMLSVKTEYFPQLTDKEQKYAHFMSKASHAGSRVVMRQVSHESEPIFDLILAIHSKLNGKYPEDDITQKQQTGLYLEYVSQFLSNLGNFKSFGDTKFIPRCEVKFFKQLLELAKINPCSSPLTLSPVDVNHEFTSHHLFSTINELIDIGIYHVEEKAALLGFPSQGYTSAYYLGLPVTPEDMALLKEQLFAELAILPENTRINKVGENSFQIWVASENVKNQITETYPSGQITLSNAVTKVEFIFGDHSREMRLVASYLKEAQKFAANDTQKAMLQEYINHFVTGSSQAHKEAQKLWVKDISPVIETNIGFIETYREPSGIIGEFESLVAIQNKERTAKFSSLVNNAEEFISLLPWSKDYEKPIFNPPDFTSLEVLTFTGSGIPAGINIPNYDDVRLKIGFKNVSLGNILSAAAKSSSKHPPSFISQEDRPIFEKYQSDSFEVQVGIHELLGHGSGKLLTEFTDGFNFDKENPPLGLDGKPVSTYYKVGETWGSKFGQLAGPFEECRAEVIAMFLLTNKKILDIFGFHDVESQDKVIYAGYLQMARAGLLALEYWNPKTGKWGQPHMQARFSIMKTFMKHSTDKNFLKLEMNSTNDDFAIKLDKSLIKTAGHECVKDYLKHLHVYKCSGDVEQGSKYFIDRSTVTPDLASLRDIVLSKRLPRRQFIQSNSYIDDNNKVTLKEYDETPQGMLQSFLDREL
SIO_010081: YOL057W
subclass of: SO_0000673
so part of: YOL057W
location: 220767..222902
location: region:220767-222902:1
so has part: feature:220767-222902:1:exon

NP_014584.1
type: Protein
SIO_000068: ncbiprotein

S000005418
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220767-222902:1:exon

YOL056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPM3
locus tag: YOL056W
so part of: sequence
location: <223268..>224179
location: region:223268-224179:1
so has part: feature:223268-224179:1:exon
subclass of: SO_0000010

854098
type: Gene
SIO_000068: ncbigene

position:223268:1
position: 223268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:224179:1
position: 224179
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:223268-224179:1:exon

YOL056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPM3
locus tag: YOL056W
product: phosphoglycerate mutase family protein GPM3
transcript id: NM_001183311.1
SIO_010081: YOL056W
subclass of: SO_0000673
so part of: YOL056W
location: <223268..>224179
location: region:223268-224179:1
so has part: feature:223268-224179:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:223268-224179:1:exon

YOL056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPM3
locus tag: YOL056W
EC number: 5.4.2.11
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication
codon start: 1
product: phosphoglycerate mutase family protein GPM3
translation: MTVTDTFKLFILRHGQSELNSENIFCGWIDAQLTEKGKSQARHSAKLIKQFCDSNNISLPQIGYTSRLIRTQQTMDVILEELGLKHTNYVITTNTNIKEELQDTRFEGSMPVLQTWRLNERHYGAWQGQRKPDILKEYGKEKYMYIRRDYNGKPPKVNLNLEMVQEENDQGSSTGYDFKEPNRHLKYGPEEKANERLPESESLCEVVVRLKPFLNNVVLSTANKISQESCVIVGHGSSVRSLLKVLEGISDEDIKDVDIPNGIPLVIELDRDNYSFVRKFYLDPESAKVNAQMVRDEGFEKNP
SIO_010081: YOL056W
subclass of: SO_0000673
so part of: YOL056W
location: 223268..224179
location: region:223268-224179:1
so has part: feature:223268-224179:1:exon

NP_014585.1
type: Protein
SIO_000068: ncbiprotein

S000005417
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:223268-224179:1:exon

YOL055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THI20
locus tag: YOL055C
so part of: sequence
location: complement(<224420..>226075)
location: region:224420-226075:-1
so has part: feature:224420-226075:-1:exon
subclass of: SO_0000010

854099
type: Gene
SIO_000068: ncbigene

position:224420:-1
position: 224420
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:226075:-1
position: 226075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224420-226075:-1:exon

YOL055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THI20
locus tag: YOL055C
product: trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase
transcript id: NM_001183310.1
SIO_010081: YOL055C
subclass of: SO_0000673
so part of: YOL055C
location: complement(<224420..>226075)
location: region:224420-226075:-1
so has part: feature:224420-226075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224420-226075:-1:exon

YOL055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THI20
locus tag: YOL055C
EC number: 2.7.1.49
EC number: 2.7.4.7
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348]
experiment: EXISTENCE:direct assay:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15967475|PMID:15614489]
experiment: EXISTENCE:direct assay:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489]
experiment: EXISTENCE:direct assay:GO:0009230 thiamine catabolic process [PMID:15967475]
experiment: EXISTENCE:direct assay:GO:0050334 thiaminase activity [PMID:15967475]
experiment: EXISTENCE:genetic interaction:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]
experiment: EXISTENCE:genetic interaction:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:10383756|PMID:15614489]
experiment: EXISTENCE:mutant phenotype:GO:0009228 thiamine biosynthetic process [PMID:10383756]
note: Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p
codon start: 1
product: trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase
translation: MTYSTVSINTPPPYLTLACNEKLPTVLSIAGTDPSGGAGIEADVKTITAHRCYAMTCITALNAQTPVKVYSINNTPKEVVFQTLESNLKDMKCNVIKTGMLTAAAIEVLHEKLLQLGENRPKLVVDPVLVATSGSSLAGKDIVSLITEKVAPFADILTPNIPECYKLLGEERKVNGLQDIFQIAKDLAKITKCSNILVKGGHIPWNDEKEKYITDVLFLGAEQKFIIFKGNFVNTTHTHGTGCTLASAIASNLARGYSLPQSVYGGIEYVQNAVAIGCDVTKETVKDNGPINHVYAVEIPLEKMLSDECFTASDVIPKKPLKSAADKIPGGNFYEYLINHPKVKPHWDSYINHEFVKKVADGTLERKKFQFFIEQDYAYLVDYARVHCIAGSKAPCLEDMEKELVIVGGVRTEMGQHEKRLKEVFGVKDPDYFQKIKRGPALRAYSRYFNDVSRRGNWQELVASLTPCLMGYGEALTKMKGKVTAPEGSVYHEWCETYASSWYREAMDEGEKLLNHILETYPPEQLDTLVTIYAEVCELETNFWTAALEYE
SIO_010081: YOL055C
subclass of: SO_0000673
so part of: YOL055C
location: complement(224420..226075)
location: region:224420-226075:-1
so has part: feature:224420-226075:-1:exon

NP_014586.1
type: Protein
SIO_000068: ncbiprotein

S000005416
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224420-226075:-1:exon

YNCO0004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0004C
so part of: sequence
location: complement(226611..226681)
location: region:226611-226681:-1
so has part: feature:226611-226681:-1:exon
subclass of: SO_0000663

854100
type: Gene
SIO_000068: ncbigene

position:226611:-1
position: 226611
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:226681:-1
position: 226681
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226611-226681:-1:exon

YNCO0004C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0004C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0004C
subclass of: SO_0000673
so part of: YNCO0004C
location: complement(226611..226681)
location: region:226611-226681:-1
so has part: feature:226611-226681:-1:exon

S000006586
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:226611-226681:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 226696..227037
location: region:226696-227037:1
so has part: feature:226696-227037:1:region

S000007158
type: SGD
SIO_000068: sgd

position:226696:1
position: 226696
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:227037:1
position: 227037
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226696-227037:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 227096..227293
location: region:227096-227293:1
so has part: feature:227096-227293:1:region

S000007156
type: SGD
SIO_000068: sgd

position:227096:1
position: 227096
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:227293:1
position: 227293
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227096-227293:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(227851..228178)
location: region:227851-228178:-1
so has part: feature:227851-228178:-1:region

S000007151
type: SGD
SIO_000068: sgd

position:227851:-1
position: 227851
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:228178:-1
position: 228178
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227851-228178:-1:region

YNCO0005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0005W
so part of: sequence
location: 228331..228404
location: region:228331-228404:1
so has part: feature:228331-228404:1:exon
subclass of: SO_0000663

854101
type: Gene
SIO_000068: ncbigene

position:228331:1
position: 228331
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:228404:1
position: 228404
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228331-228404:1:exon

YNCO0005W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0005W
product: tRNA-Asn
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0005W
subclass of: SO_0000673
so part of: YNCO0005W
location: 228331..228404
location: region:228331-228404:1
so has part: feature:228331-228404:1:exon

S000006675
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228331-228404:1:exon

YOL054W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSH1
locus tag: YOL054W
so part of: sequence
location: <228614..>229834
location: region:228614-229834:1
so has part: feature:228614-229834:1:exon
subclass of: SO_0000010

854102
type: Gene
SIO_000068: ncbigene

position:228614:1
position: 228614
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229834:1
position: 229834
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228614-229834:1:exon

YOL054W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSH1
locus tag: YOL054W
product: ubiquitin-protein ligase PSH1
transcript id: NM_001183309.1
SIO_010081: YOL054W
subclass of: SO_0000673
so part of: YOL054W
location: <228614..>229834
location: region:228614-229834:1
so has part: feature:228614-229834:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228614-229834:1:exon

YOL054W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSH1
locus tag: YOL054W
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:21070970]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:21070970|PMID:21070971]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21070970|PMID:21070971]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21070970|PMID:21070971]
note: E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p; ubiquitination of Cse4p may be antagonized by Scm3p; interacts with the FACT complex preventing mislocalization of Cse4p to euchromatin independent of Slx5p; formyl-methionine/N-recognin component of N-end rule pathway mediating destruction of formylated cytosolic proteins elevated in response to starvation or stationary phase entry
codon start: 1
product: ubiquitin-protein ligase PSH1
translation: MGDELHNRLLHQNDGTKDAILYKIIESLVCSICHDYMFVPMMTPCGHNYCYGCLNTWFASNTQKELACPQCRSDITTIPALNTTLQQYLSFILEKLRDQNDESFKKLLTTKTKEENDYKNDKEKDTLFDKVFKNSALAVADDSDDGITRCSNCHWELDPDEVEDGNVCPHCNARIRNYAGGRDEFDEEEYSEGELDEIRESMRRRRENRFASTNPFANRDDVSSEDDDSSEEEPMREHIPLGRWARSHNRSIAVDAVDDEDDEEEDEEEEEEMDSDLKDFIEDDEDDEDEDGSRRNLVLSALKNRHVIITDDEEEEQRRHATEEEDRDSDFYEHNDDGFVSGDSLDEDQKEVTRIQSSSDSEDRSLSYSGSSDVKDNNDDNTEELDDPQPKRQKRFRVVLGDSDDE
SIO_010081: YOL054W
subclass of: SO_0000673
so part of: YOL054W
location: 228614..229834
location: region:228614-229834:1
so has part: feature:228614-229834:1:exon

NP_014587.1
type: Protein
SIO_000068: ncbiprotein

S000005415
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228614-229834:1:exon

YOL053W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM39
locus tag: YOL053W
so part of: sequence
location: <230085..>231272
location: region:230085-231272:1
so has part: feature:230085-231272:1:exon
subclass of: SO_0000010

854103
type: Gene
SIO_000068: ncbigene

position:230085:1
position: 230085
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:231272:1
position: 231272
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:230085-231272:1:exon

YOL053W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM39
locus tag: YOL053W
product: Aim39p
transcript id: NM_001183308.1
SIO_010081: YOL053W
subclass of: SO_0000673
so part of: YOL053W
location: <230085..>231272
location: region:230085-231272:1
so has part: feature:230085-231272:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:230085-231272:1:exon

YOL053W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM39
locus tag: YOL053W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; null mutant displays elevated frequency of mitochondrial genome loss; localizes to mitochondria, cytosol and to the peroxisome in a Pex5p-dependent manner in glucose
codon start: 1
product: Aim39p
translation: MWGLCKKHFPSNKIQVQERNKALKPKKSGSEHKTKQLFPVFNCKKKEKGVMIRFAILRNANTSLLSARSICLFTQAPTYCHVRLNTLNKSITTKRNSLTESKRHVHDGKHFFTTPHQQQQTKLGEIEEGHSPNIKGEDLRSIGQAITHQRNKRRKQIWSAIFGGIFGVILGYSLIYRVIYLKEQSFLPLFPSSKIRKLSTRDLKKVDVNQVQKLSKLRVLEILSGHDMIKEQYGVPLLDKDGNSPTLNEFSMWCEDQDPCVTGIVMEPDDKRDSSHTWYRIPFVCKWRITHRPISIRGTIDDLLNRIGLETADLFEIISPERVYGSFKYEYPLQGDSHALHLWFHGEIELDDDSLIVYNGKYHVDVKLQEIDLFRREKNGQLIQYVLYKNEAGDK
SIO_010081: YOL053W
subclass of: SO_0000673
so part of: YOL053W
location: 230085..231272
location: region:230085-231272:1
so has part: feature:230085-231272:1:exon

NP_014588.1
type: Protein
SIO_000068: ncbiprotein

S000005414
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:230085-231272:1:exon

YOL052C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOL053C-A
gene: DDR2
locus tag: YOL052C-A
gene synonym: YOL053C-A
so part of: sequence
location: complement(<231570..>231755)
location: region:231570-231755:-1
so has part: feature:231570-231755:-1:exon
subclass of: SO_0000010

854104
type: Gene
SIO_000068: ncbigene

position:231570:-1
position: 231570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:231755:-1
position: 231755
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231570-231755:-1:exon

YOL052C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOL053C-A
gene: DDR2
locus tag: YOL052C-A
gene synonym: YOL053C-A
product: Ddr2p
transcript id: NM_001183307.1
SIO_010081: YOL052C-A
subclass of: SO_0000673
so part of: YOL052C-A
location: complement(<231570..>231755)
location: region:231570-231755:-1
so has part: feature:231570-231755:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:231570-231755:-1:exon

YOL052C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOL053C-A
gene: DDR2
locus tag: YOL052C-A
gene synonym: YOL053C-A
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:expression pattern:GO:0006974 cellular response to DNA damage stimulus [PMID:9473471]
experiment: EXISTENCE:expression pattern:GO:0009267 cellular response to starvation [PMID:9473471]
experiment: EXISTENCE:expression pattern:GO:0034605 cellular response to heat [PMID:9473471]
experiment: EXISTENCE:expression pattern:GO:0070301 cellular response to hydrogen peroxide [PMID:9473471]
note: Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication
codon start: 1
product: Ddr2p
translation: MKVSQVFISAISVFGLATSVNAQNASNTTSNAAPALHAQNGQLLNAGVVGAAVGGALAFLI
SIO_010081: YOL052C-A
subclass of: SO_0000673
so part of: YOL052C-A
location: complement(231570..231755)
location: region:231570-231755:-1
so has part: feature:231570-231755:-1:exon

NP_014589.1
type: Protein
SIO_000068: ncbiprotein

S000005413
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:231570-231755:-1:exon

YOL052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPE2
locus tag: YOL052C
so part of: sequence
location: complement(<232446..>233636)
location: region:232446-233636:-1
so has part: feature:232446-233636:-1:exon
subclass of: SO_0000010

854105
type: Gene
SIO_000068: ncbigene

position:232446:-1
position: 232446
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233636:-1
position: 233636
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232446-233636:-1:exon

YOL052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPE2
locus tag: YOL052C
product: adenosylmethionine decarboxylase SPE2
transcript id: NM_001183306.1
SIO_010081: YOL052C
subclass of: SO_0000673
so part of: YOL052C
location: complement(<232446..>233636)
location: region:232446-233636:-1
so has part: feature:232446-233636:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232446-233636:-1:exon

YOL052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPE2
locus tag: YOL052C
EC number: 4.1.1.50
experiment: EXISTENCE:direct assay:GO:0004014 adenosylmethionine decarboxylase activity [PMID:2266128]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006597 spermine biosynthetic process [PMID:7929015]
experiment: EXISTENCE:mutant phenotype:GO:0008295 spermidine biosynthetic process [PMID:7929015]
experiment: EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]
note: S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
codon start: 1
product: adenosylmethionine decarboxylase SPE2
translation: MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI
SIO_010081: YOL052C
subclass of: SO_0000673
so part of: YOL052C
location: complement(232446..233636)
location: region:232446-233636:-1
so has part: feature:232446-233636:-1:exon

NP_014590.1
type: Protein
SIO_000068: ncbiprotein

S000005412
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232446-233636:-1:exon

YNCO0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR81
locus tag: YNCO0006W
so part of: sequence
location: 234346..234546
location: region:234346-234546:1
so has part: feature:234346-234546:1:exon
subclass of: SO_0000578

9164973
type: Gene
SIO_000068: ncbigene

position:234346:1
position: 234346
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:234546:1
position: 234546
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234346-234546:1:exon

YNCO0006W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR81
locus tag: YNCO0006W
product: SNR81
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:15306656]
experiment: EXISTENCE:curator inference:GO:0031429 box H/ACA snoRNP complex [PMID:15306656]
experiment: EXISTENCE:direct assay:GO:0030565 snRNA pseudouridylation guide activity [PMID:15962000]
experiment: EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15306656]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:15306656]
experiment: EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U1052, constitutive pseudouridylation of U2 snRNA (LSR1) at position 42, and stress-induced U2 pseudouridylation at position 93
transcript id: NR_132256.1
SIO_010081: YNCO0006W
subclass of: SO_0000673
so part of: YNCO0006W
location: 234346..234546
location: region:234346-234546:1
so has part: feature:234346-234546:1:exon

S000081375
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234346-234546:1:exon

YOL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ABE1
alternative label: MED15
alternative label: RAR3
alternative label: SDS4
alternative label: SPT13
gene: GAL11
locus tag: YOL051W
gene synonym: ABE1; MED15; RAR3; SDS4; SPT13
so part of: sequence
location: <234940..>238185
location: region:234940-238185:1
so has part: feature:234940-238185:1:exon
subclass of: SO_0000010

854106
type: Gene
SIO_000068: ncbigene

position:234940:1
position: 234940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238185:1
position: 238185
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234940-238185:1:exon

YOL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ABE1
alternative label: MED15
alternative label: RAR3
alternative label: SDS4
alternative label: SPT13
gene: GAL11
locus tag: YOL051W
gene synonym: ABE1; MED15; RAR3; SDS4; SPT13
product: Gal11p
transcript id: NM_001183305.1
SIO_010081: YOL051W
subclass of: SO_0000673
so part of: YOL051W
location: <234940..>238185
location: region:234940-238185:1
so has part: feature:234940-238185:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234940-238185:1:exon

YOL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ABE1
alternative label: MED15
alternative label: RAR3
alternative label: SDS4
alternative label: SPT13
gene: GAL11
locus tag: YOL051W
gene synonym: ABE1; MED15; RAR3; SDS4; SPT13
experiment: EXISTENCE:direct assay:GO:0001095 TFIIE-class transcription factor complex binding [PMID:8790357]
experiment: EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:10973956]
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:8378310]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986|PMID:8378310]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:genetic interaction:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]
experiment: EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
codon start: 1
product: Gal11p
translation: MSAAPVQDKDTLSNAERAKNVNGLLQVLMDINTLNGGSSDTADKIRIHAKNFEAALFAKSSSKKEYMDSMNEKVAVMRNTYNTRKNAVTAAAANNNIKPVEQHHINNLKNSGNSANNMNVNMNLNPQMFLNQQAQARQQVAQQLRNQQQQQQQQQQQQRRQLTPQQQQLVNQMKVAPIPKQLLQRIPNIPPNINTWQQVTALAQQKLLTPQDMEAAKEVYKIHQQLLFKARLQQQQAQAQAQANNNNNGLPQNGNINNNINIPQQQQMQPPNSSANNNPLQQQSSQNTVPNVLNQINQIFSPEEQRSLLQEAIETCKNFEKTQLGSTMTEPVKQSFIRKYINQKALRKIQALRDVKNNNNANNNGSNLQRAQNVPMNIIQQQQQQNTNNNDTIATSATPNAAAFSQQQNASSKLYQMQQQQQAQAQAQAQAQAQAQAQAQAQAAQAAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAHAQHQPSQQPQQAQQQPNPLHGLTPTAKDVEVIKQLSLDASKTNLRLTDVTNSLSNEEKEKIKMKLKQGQKLFVQVSNFAPQVYIITKNENFLKEVFQLRIFVKEILEKCAEGIFVVKLDTVDRLIIKYQKYWESMRIQILRRQAILRQQQQMANNNGNPGTTSTGNNNNIATQQNMQQSLQQMQHLQQLKMQQQQQQQQQQQQQQQQQQQQQQQHIYPSSTPGVANYSAMANAPGNNIPYMNHKNTSSMDFLNSMENTPKVPVSAAATPSLNKTINGKVNGRTKSNTIPVTSIPSTNKKLSISNAASQQPTPRSASNTAKSTPNTNPSPLKTQTKNGTPNPNNMKTVQSPMGAQPSYNSAIIENAFRKEELLLKDLEIRKLEISSRFKHRQEIFKDSPMDLFMSTLGDCLGIKDEEMLTSCTIPKAVVDHINGSGKRKPTKAAQRARDQDSIDISIKDNKLVMKSKFNKSNRSYSIALSNVAAIFKGIGGNFKDLSTLVHSSSPSTSSNMDVGNPRKRKASVLEISPQDSIASVLSPDSNIMSDSKKIKVDSPDDPFMTKSGATTSEKQEVTNEAPFLTSGTSSEQFNVWDWNNWTSAT
SIO_010081: YOL051W
subclass of: SO_0000673
so part of: YOL051W
location: 234940..238185
location: region:234940-238185:1
so has part: feature:234940-238185:1:exon

NP_014591.1
type: Protein
SIO_000068: ncbiprotein

S000005411
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234940-238185:1:exon

YOL049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GSH2
locus tag: YOL049W
so part of: sequence
location: <238619..>240094
location: region:238619-240094:1
so has part: feature:238619-240094:1:exon
subclass of: SO_0000010

854108
type: Gene
SIO_000068: ncbigene

position:238619:1
position: 238619
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:240094:1
position: 240094
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:238619-240094:1:exon

YOL049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GSH2
locus tag: YOL049W
product: glutathione synthase
transcript id: NM_001183303.1
SIO_010081: YOL049W
subclass of: SO_0000673
so part of: YOL049W
location: <238619..>240094
location: region:238619-240094:1
so has part: feature:238619-240094:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:238619-240094:1:exon

YOL049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GSH2
locus tag: YOL049W
EC number: 6.3.2.3
experiment: EXISTENCE:direct assay:GO:0004363 glutathione synthase activity [PMID:9512666]
experiment: EXISTENCE:mutant phenotype:GO:0006750 glutathione biosynthetic process [PMID:9512666]
note: Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
codon start: 1
product: glutathione synthase
translation: MAHYPPSKDQLNELIQEVNQWAITNGLSMYPPKFEENPSNASVSPVTIYPTPIPRKCFDEAVQIQPVFNELYARITQDMAQPDSYLHKTTEALALSDSEFTGKLWSLYLATLKSAQYKKQNFRLGIFRSDYLIDKKKGTEQIKQVEFNTVSVSFAGLSEKVDRLHSYLNRANKYDPKGPIYNDQNMVISDSGYLLSKALAKAVESYKSQQSSSTTSDPIVAFIVQRNERNVFDQKVLELNLLEKFGTKSVRLTFDDVNDKLFIDDKTGKLFIRDTEQEIAVVYYRTGYTTTDYTSEKDWEARLFLEKSFAIKAPDLLTQLSGSKKIQQLLTDEGVLGKYISDAEKKSSLLKTFVKIYPLDDTKLGREGKRLALSEPSKYVLKPQREGGGNNVYKENIPNFLKGIEERHWDAYILMELIEPELNENNIILRDNKSYNEPIISELGIYGCVLFNDEQVLSNEFSGSLLRSKFNTSNEGGVAAGFGCLDSIILY
SIO_010081: YOL049W
subclass of: SO_0000673
so part of: YOL049W
location: 238619..240094
location: region:238619-240094:1
so has part: feature:238619-240094:1:exon

NP_014593.1
type: Protein
SIO_000068: ncbiprotein

S000005409
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:238619-240094:1:exon

YOL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRT8
locus tag: YOL048C
so part of: sequence
location: complement(<240204..>241310)
location: region:240204-241310:-1
so has part: feature:240204-241310:-1:exon
subclass of: SO_0000010

854109
type: Gene
SIO_000068: ncbigene

position:240204:-1
position: 240204
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241310:-1
position: 241310
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:240204-241310:-1:exon

YOL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRT8
locus tag: YOL048C
product: Rrt8p
transcript id: NM_001183302.1
SIO_010081: YOL048C
subclass of: SO_0000673
so part of: YOL048C
location: complement(join(<240204..240947,241026..>241310))
location: region:240204-241310:-1
so has part: feature:241026-241310:-1:exon
so has part: feature:240204-240947:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241026-241310:-1:exon

position:241026:-1
position: 241026
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:240204-240947:-1:exon

position:240947:-1
position: 240947
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YOL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRT8
locus tag: YOL048C
experiment: EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:23966878]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:23966878]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:23966878]
note: Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
codon start: 1
product: Rrt8p
translation: MKAGIELISHSQASHATYANSMTLAEKGPQRLKRQFKEHSSSKESNVSRWLKIFIRQFDIWFPETIPTMKVRYELLRKNFIKEIFNSRAFIYPFLGFYEVLTNPVYWKHILLFAVCYALIFVTIAGLFYVTLVPLLVTWAILLLGPLGVILVHIQWILQTNVLTAFVCRTLVLTHITNQIFDISLVLQDQDEFLNEVKVLPKPQKPHRKIDEPDAVRNFNTIKGSRIFKIPRLLFRMFFKVSNFTSLTLLSLIPIVGPILANQLMAPKRTFTYLQRYFLLKGFSKKQAKDFQYEHYASFICFGMSAGLLELIPFFTIVTISSNTVGAAKWCTSLLKGERKKE
SIO_010081: YOL048C
subclass of: SO_0000673
so part of: YOL048C
location: complement(join(240204..240947,241026..241310))
location: region:240204-241310:-1
so has part: feature:241026-241310:-1:exon
so has part: feature:240204-240947:-1:exon

NP_014594.2
type: Protein
SIO_000068: ncbiprotein

S000005408
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241026-241310:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:240204-240947:-1:exon

YOL047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LDS2
locus tag: YOL047C
so part of: sequence
location: complement(<241614..>242747)
location: region:241614-242747:-1
so has part: feature:241614-242747:-1:exon
subclass of: SO_0000010

854110
type: Gene
SIO_000068: ncbigene

position:241614:-1
position: 241614
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:242747:-1
position: 242747
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241614-242747:-1:exon

YOL047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LDS2
locus tag: YOL047C
product: Lds2p
transcript id: NM_001183301.1
SIO_010081: YOL047C
subclass of: SO_0000673
so part of: YOL047C
location: complement(join(<241614..242441,242505..>242747))
location: region:241614-242747:-1
so has part: feature:242505-242747:-1:exon
so has part: feature:241614-242441:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:242505-242747:-1:exon

position:242505:-1
position: 242505
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:241614-242441:-1:exon

position:242441:-1
position: 242441
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YOL047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LDS2
locus tag: YOL047C
experiment: EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:23966878]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:23966878]
experiment: EXISTENCE:direct assay:GO:0005633 ascus lipid droplet [PMID:23966878]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141]
experiment: EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]
note: Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
codon start: 1
product: Lds2p
translation: MSTRPQPDWYYHRHPYASTPLAEGEEPQLLPIQDQGNHKKSKIWMAYKAPIVRWYKNAMLVKDNFWKDLESSHQIIWYPYKGISESVGNSDYLHLFFLIFGYYLLNLLLIVAFTSILAWSLLVCIYLPFLGLFALPLAYMQTILISTTLCNSMVKGTDFVLFTRIYGVTFARKGLTELSEACETISFTPFVYRRSHRLGGLFSKRFYLVSLPQFFIFFFWYIFIAFMFLLLLLVPIVGPITINMLPFSPGMGFYYFEPYFVDVLHLDSRKLSKVYYKGFAKWLLYSISSGLLESIPILGGLFIGTNAVGASLWIVKEIKDRDQPAVPPSPPAEPEEPTVGSYAPPIQQSIAHINPP
SIO_010081: YOL047C
subclass of: SO_0000673
so part of: YOL047C
location: complement(join(241614..242441,242505..242747))
location: region:241614-242747:-1
so has part: feature:242505-242747:-1:exon
so has part: feature:241614-242441:-1:exon

NP_014595.2
type: Protein
SIO_000068: ncbiprotein

S000005407
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:242505-242747:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:241614-242441:-1:exon

YOL045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSK2
locus tag: YOL045W
so part of: sequence
location: <243497..>246802
location: region:243497-246802:1
so has part: feature:243497-246802:1:exon
subclass of: SO_0000010

854111
type: Gene
SIO_000068: ncbigene

position:243497:1
position: 243497
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246802:1
position: 246802
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243497-246802:1:exon

YOL045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSK2
locus tag: YOL045W
product: serine/threonine protein kinase PSK2
transcript id: NM_001183299.1
SIO_010081: YOL045W
subclass of: SO_0000673
so part of: YOL045W
location: <243497..>246802
location: region:243497-246802:1
so has part: feature:243497-246802:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243497-246802:1:exon

YOL045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSK2
locus tag: YOL045W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:12372297]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:12372297]
experiment: EXISTENCE:genetic interaction:GO:0060917 regulation of (1->6)-beta-D-glucan biosynthetic process [PMID:17531808]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:12372297]
experiment: EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:12372297]
experiment: EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:26310304]
note: PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase PSK2
translation: MTYPVSAAAPADISYSKNTPLVGLSKPPCLYQHASSSVDSFSSTFSDDDRSDLVAVPNESPHAFSYNPISPNSLGVRLTILRRSLEIMVNSPDILHELKKKAPVIAYPPSLRHTRNLTETATLSASRDPLNGSLISPLVSNMPSPASRPVIQRATSLMVLPDNDTASKLNPAKSELENLLFLLNLALENNSFERASDLHMLSLLNIKKINFDSDIQKSETLKKVLLDSLAEPFFENYKKFPHKDLGSKSQYNEYEEKHDDIVSLADIKPQQDYSRILHPFTSAKNSGPEAIFTCSQQYPWNFKAANDLACLTFGISKNVIKALTLLDLIHTDSRNFVLEKIMNAEDDNQEIVFTGETIPIVQPNSTSNNNVPNLIWASLWAKRKNGLLVCVFEKTPCDYIDVMLNLRDFSVDSIIDTTHFLENFDKKKQQESTSPMTEKKTVKFANEIHDIGSVSHSLSKLIDDVRFGKVFSADDDLLPLSIRVANHVNEERYFTLNCLSENIPCAVTTSVLENEIKLKIHSLPYQAGLFIVDSHTLSLLSFNKSVAKNMFGLRLHELAGSSVTKLVPSLADMISYINKTYPMLNITLPENKGLVLTEHFFRKIEAEMHHDKDSFYTSIGLDGCHKDGNLIKVDVQLRVLNTNAVLLWITHSRDVVIENYTTVPSQLPMLKENEIDVVGSRGSSSASSKKSSEKIPVNTLKAMADLSISSAETISNSDDEVDLNQVNEKLRETSCGKVRGIESNDNNNYDDDMTMVDDPELKHKIELTKMYTQDKSKFVKDDNFKVDEKFIMRIIEPINGEEIKKETNELDKRNSTLKATYLTTPEANIGSQKRIKKFSDFTILQVMGEGAYGKVNLCIHNREHYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMATLNKNSQENILKLLDFFEDDDYYYIETPVHGETGSIDLFDVIEFKKDMVEHEAKLVFKQVVASIKHLHDQGIVHRDIKDENVIVDSHGFVKLIDFGSAAYIKSGPFDVFVGTMDYAAPEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEILEGELRFDKSEHVSEECISLIKRILTREVDKRPTIDEIYEDKWLKI
SIO_010081: YOL045W
subclass of: SO_0000673
so part of: YOL045W
location: 243497..246802
location: region:243497-246802:1
so has part: feature:243497-246802:1:exon

NP_014597.1
type: Protein
SIO_000068: ncbiprotein

S000005405
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243497-246802:1:exon

YOL044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS21
gene: PEX15
locus tag: YOL044W
gene synonym: PAS21
so part of: sequence
location: <247150..>248301
location: region:247150-248301:1
so has part: feature:247150-248301:1:exon
subclass of: SO_0000010

854113
type: Gene
SIO_000068: ncbigene

position:247150:1
position: 247150
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248301:1
position: 248301
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:247150-248301:1:exon

YOL044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS21
gene: PEX15
locus tag: YOL044W
gene synonym: PAS21
product: Pex15p
transcript id: NM_001183298.1
SIO_010081: YOL044W
subclass of: SO_0000673
so part of: YOL044W
location: <247150..>248301
location: region:247150-248301:1
so has part: feature:247150-248301:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:247150-248301:1:exon

YOL044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS21
gene: PEX15
locus tag: YOL044W
gene synonym: PAS21
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9405362]
experiment: EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:12808025]
experiment: EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:12808025]
experiment: EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:12808025|PMID:16007078|PMID:16911527]
note: Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly
codon start: 1
product: Pex15p
translation: MAASEIMNNLPMHSLDSSLRDLLNDDLFIESDESTKSVNDQRSEVFQECVNLFIKRDIKDCLEKMSEVGFIDITVFKSNPMILDLFVSACDIMPSFTKLGLTLQSEILNIFTLDTPQCIETRKIILGDLSKLLVINKFFRCCIKVIQFNLTDHTEQEEKTLELESIMSDFIFVYITKMRTTIDVVGLQELIEIFIFQVKVKLHHKKPSPNMYWALCKTLPKLSPTLKGLYLSKDVSIEDAILNSIDNKIQKDKAKSKGKQRGVKQKIHHFHEPMLHNSSEEQVKVEDAFNQRTSTDSRLQSTGTAPRKKNNDITVLAGSFWAVLKHHFTRSVLNKNGLLLTGLLLLLCLKKYKSLMAIFKHVPAAFHTVYPQIVGLLKLLASI
SIO_010081: YOL044W
subclass of: SO_0000673
so part of: YOL044W
location: 247150..248301
location: region:247150-248301:1
so has part: feature:247150-248301:1:exon

NP_014598.1
type: Protein
SIO_000068: ncbiprotein

S000005404
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:247150-248301:1:exon

YOL043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCR2
gene: NTG2
locus tag: YOL043C
gene synonym: SCR2
so part of: sequence
location: complement(<248392..>249534)
location: region:248392-249534:-1
so has part: feature:248392-249534:-1:exon
subclass of: SO_0000010

854114
type: Gene
SIO_000068: ncbigene

position:248392:-1
position: 248392
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:249534:-1
position: 249534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248392-249534:-1:exon

YOL043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCR2
gene: NTG2
locus tag: YOL043C
gene synonym: SCR2
product: bifunctional N-glycosylase/AP lyase NTG2
transcript id: NM_001183297.1
SIO_010081: YOL043C
subclass of: SO_0000673
so part of: YOL043C
location: complement(<248392..>249534)
location: region:248392-249534:-1
so has part: feature:248392-249534:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248392-249534:-1:exon

YOL043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCR2
gene: NTG2
locus tag: YOL043C
gene synonym: SCR2
EC number: 4.2.99.18
experiment: EXISTENCE:direct assay:GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [PMID:9020769]
experiment: EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:14500818]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10471279|PMID:19029246]
experiment: EXISTENCE:direct assay:GO:0006284 base-excision repair [PMID:14500818]
experiment: EXISTENCE:direct assay:GO:0006285 base-excision repair, AP site formation [PMID:9826748]
note: DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
codon start: 1
product: bifunctional N-glycosylase/AP lyase NTG2
translation: MREESRSRKRKHIPVDIEEVEVRSKYFKKNERTVELVKENKINKDLQNYGGVNIDWIKALKPIEYFEWIESRTCDDPRTWGRPITKEEMINDSGAKVPESFLPIYNRVRLMRSKVKTPVDAMGCSMIPVLVSNKCGIPSEKVDPKNFRLQFLIGTMLSAQTRDERMAQAALNITEYCLNTLKIAEGITLDGLLKIDEPVLANLIRCVSFYTRKANFIKRTAQLLVDNFDSDIPYDIEGILSLPGVGPKMGYLTLQKGWGLIAGICVDVHVHRLCKMWNWVDPIKCKTAEHTRKELQVWLPHSLWYEINTVLVGFGQLICMARGKRCDLCLANDVCNARNEKLIESSKFHQLEDKEDIEKVYSHWLDTVTNGITTERHKKK
SIO_010081: YOL043C
subclass of: SO_0000673
so part of: YOL043C
location: complement(248392..249534)
location: region:248392-249534:-1
so has part: feature:248392-249534:-1:exon

NP_014599.1
type: Protein
SIO_000068: ncbiprotein

S000005403
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248392-249534:-1:exon

YOL042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NGL1
locus tag: YOL042W
so part of: sequence
location: <249825..>250916
location: region:249825-250916:1
so has part: feature:249825-250916:1:exon
subclass of: SO_0000010

854115
type: Gene
SIO_000068: ncbigene

position:249825:1
position: 249825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:250916:1
position: 250916
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:249825-250916:1:exon

YOL042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NGL1
locus tag: YOL042W
product: RNA exonuclease
transcript id: NM_001183296.1
SIO_010081: YOL042W
subclass of: SO_0000673
so part of: YOL042W
location: <249825..>250916
location: region:249825-250916:1
so has part: feature:249825-250916:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:249825-250916:1:exon

YOL042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NGL1
locus tag: YOL042W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
note: Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: RNA exonuclease
translation: MFTRRFIPVVQSTKQNIGKYVRKDARFTLLTYNMLSPSYMWPQVYTYVAEPYKNWSYRHRLLEKELLNTFKADIMCLQEMTARDYEDYWHDSIGVDVNYGSKFISKTPPKYWKKPVKDMDGVSIFYNLAKFDFISSSGIYLNQLLNVFNQRELKYLYNKKVTLTDGASNVIGEDSLLDVLKGKNQVCLFVSLRHKETGTIFVVLNTHLYWKYDEVKLTQCMIIMRELSKIIKQLLPGDVKGQERVKILFTGDLNSTRDSLVVNFLQGQIVSHGDLNLINPMRPYLDRCVYDDIPKDYFVHTCYSGKLKGIFDYVWYHDSDFLLTKILTGNEVSDELLASNQLGLPNENHPSDHIPLLTEFKIL
SIO_010081: YOL042W
subclass of: SO_0000673
so part of: YOL042W
location: 249825..250916
location: region:249825-250916:1
so has part: feature:249825-250916:1:exon

NP_014600.1
type: Protein
SIO_000068: ncbiprotein

S000005402
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:249825-250916:1:exon

YOL041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP12
locus tag: YOL041C
so part of: sequence
location: complement(<251267..>252646)
location: region:251267-252646:-1
so has part: feature:251267-252646:-1:exon
subclass of: SO_0000010

854116
type: Gene
SIO_000068: ncbigene

position:251267:-1
position: 251267
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:252646:-1
position: 252646
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251267-252646:-1:exon

YOL041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP12
locus tag: YOL041C
product: Nop12p
transcript id: NM_001183295.1
SIO_010081: YOL041C
subclass of: SO_0000673
so part of: YOL041C
location: complement(<251267..>252646)
location: region:251267-252646:-1
so has part: feature:251267-252646:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251267-252646:-1:exon

YOL041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP12
locus tag: YOL041C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11452019]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0030684 preribosome [PMID:17922018]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21811236|PMID:11452019]
note: Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
codon start: 1
product: Nop12p
translation: MSSAIDNLFGNIDEKKIESSVDKLFSSSCGPINKLEVKSKTRTVLPDSKKRERAAEADQEEKEASKPDVSDEQTEEVALPKVKKAKKSKRNDEDEDLEARYYAKLLNEEAEAEDDKPTVTKTDETSVPLTSAAKKVDFKEDELEKAERTVFIGNILSTVITSKKVYKEFKKLFGTNPIAETEESGNEKEEESSKKSDNNEFAIESIRFRSISFDEALPRKVAFVQQKFHKSRDTINAYIVYKNKSAVRKICSNLNAVVFQDHHLRVDSVAHPAPHDKKRSIFVGNLDFEEIEESLWKHFEPCGDIEYVRIIRDSKTNMGKGFAYVQFKDLQSVNKALLLNEKPMKSQKQEDENTKKPTKKARKLRVSRCKNMKKGTTIGTGLDRNGLTDSQRTRAGRAKKILGKADRATLGQEITIEGLRAKKGEGSTHLKKKKQRSATGRVTKRSIAFKKAQAEKSKK
SIO_010081: YOL041C
subclass of: SO_0000673
so part of: YOL041C
location: complement(251267..252646)
location: region:251267-252646:-1
so has part: feature:251267-252646:-1:exon

NP_014601.1
type: Protein
SIO_000068: ncbiprotein

S000005401
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251267-252646:-1:exon

YOL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS21
gene: RPS15
locus tag: YOL040C
gene synonym: RPS21
so part of: sequence
location: complement(<253149..>253577)
location: region:253149-253577:-1
so has part: feature:253149-253577:-1:exon
subclass of: SO_0000010

854117
type: Gene
SIO_000068: ncbigene

position:253149:-1
position: 253149
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253577:-1
position: 253577
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253149-253577:-1:exon

YOL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS21
gene: RPS15
locus tag: YOL040C
gene synonym: RPS21
product: ribosomal 40S subunit protein S15
transcript id: NM_001183294.1
SIO_010081: YOL040C
subclass of: SO_0000673
so part of: YOL040C
location: complement(<253149..>253577)
location: region:253149-253577:-1
so has part: feature:253149-253577:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253149-253577:-1:exon

YOL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS21
gene: RPS15
locus tag: YOL040C
gene synonym: RPS21
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:15167894|PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
codon start: 1
product: ribosomal 40S subunit protein S15
translation: MSQAVNAKKRVFKTHSYRGVDLEKLLEMSTEDFVKLAPARVRRRFARGMTSKPAGFMKKLRAAKLAAPENEKPAPVRTHMRNMIIVPEMIGSVVGIYNGKAFNQVEIRPEMLGHYLGEFSITYTPVRHGRAGATTSRFIPLK
SIO_010081: YOL040C
subclass of: SO_0000673
so part of: YOL040C
location: complement(253149..253577)
location: region:253149-253577:-1
so has part: feature:253149-253577:-1:exon

NP_014602.1
type: Protein
SIO_000068: ncbiprotein

S000005400
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253149-253577:-1:exon

YOL039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL44
alternative label: RPLA2
gene: RPP2A
locus tag: YOL039W
gene synonym: RPL44; RPLA2
so part of: sequence
location: <254297..>254617
location: region:254297-254617:1
so has part: feature:254297-254617:1:exon
subclass of: SO_0000010

854118
type: Gene
SIO_000068: ncbigene

position:254297:1
position: 254297
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:254617:1
position: 254617
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:254297-254617:1:exon

YOL039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL44
alternative label: RPLA2
gene: RPP2A
locus tag: YOL039W
gene synonym: RPL44; RPLA2
product: ribosomal protein P2A
transcript id: NM_001183293.1
SIO_010081: YOL039W
subclass of: SO_0000673
so part of: YOL039W
location: <254297..>254617
location: region:254297-254617:1
so has part: feature:254297-254617:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:254297-254617:1:exon

YOL039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL44
alternative label: RPLA2
gene: RPP2A
locus tag: YOL039W
gene synonym: RPL44; RPLA2
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:9559554]
note: Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
codon start: 1
product: ribosomal protein P2A
translation: MKYLAAYLLLNAAGNTPDATKIKAILESVGIEIEDEKVSSVLSALEGKSVDELITEGNEKLAAVPAAGPASAGGAAAASGDAAAEEEKEEEAAEESDDDMGFGLFD
SIO_010081: YOL039W
subclass of: SO_0000673
so part of: YOL039W
location: 254297..254617
location: region:254297-254617:1
so has part: feature:254297-254617:1:exon

NP_014603.1
type: Protein
SIO_000068: ncbiprotein

S000005399
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:254297-254617:1:exon

YOL038C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL038C-A
so part of: sequence
location: complement(<254926..>255021)
location: region:254926-255021:-1
so has part: feature:254926-255021:-1:exon
subclass of: SO_0000010

1466476
type: Gene
SIO_000068: ncbigene

position:254926:-1
position: 254926
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255021:-1
position: 255021
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:254926-255021:-1:exon

YOL038C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL038C-A
product: uncharacterized protein
transcript id: NM_001184641.1
SIO_010081: YOL038C-A
subclass of: SO_0000673
so part of: YOL038C-A
location: complement(<254926..>255021)
location: region:254926-255021:-1
so has part: feature:254926-255021:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:254926-255021:-1:exon

YOL038C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL038C-A
note: hypothetical protein; identified by SAGE analysis
codon start: 1
product: uncharacterized protein
translation: MKYMGSFLRKAATTNLFNSIKKRKVQNRAMS
SIO_010081: YOL038C-A
subclass of: SO_0000673
so part of: YOL038C-A
location: complement(254926..255021)
location: region:254926-255021:-1
so has part: feature:254926-255021:-1:exon

NP_878164.1
type: Protein
SIO_000068: ncbiprotein

S000028812
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:254926-255021:-1:exon

YOL038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRE6
locus tag: YOL038W
so part of: sequence
location: <255337..>256101
location: region:255337-256101:1
so has part: feature:255337-256101:1:exon
subclass of: SO_0000010

854119
type: Gene
SIO_000068: ncbigene

position:255337:1
position: 255337
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256101:1
position: 256101
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255337-256101:1:exon

YOL038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRE6
locus tag: YOL038W
product: proteasome core particle subunit alpha 4
transcript id: NM_001183292.1
SIO_010081: YOL038W
subclass of: SO_0000673
so part of: YOL038W
location: <255337..>256101
location: region:255337-256101:1
so has part: feature:255337-256101:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255337-256101:1:exon

YOL038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRE6
locus tag: YOL038W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18504300]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9799224]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
note: Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
codon start: 1
product: proteasome core particle subunit alpha 4
translation: MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH
SIO_010081: YOL038W
subclass of: SO_0000673
so part of: YOL038W
location: 255337..256101
location: region:255337-256101:1
so has part: feature:255337-256101:1:exon

NP_014604.1
type: Protein
SIO_000068: ncbiprotein

S000005398
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255337-256101:1:exon

YOL036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL036W
so part of: sequence
location: <256745..>259030
location: region:256745-259030:1
so has part: feature:256745-259030:1:exon
subclass of: SO_0000010

854120
type: Gene
SIO_000068: ncbigene

position:256745:1
position: 256745
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259030:1
position: 259030
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256745-259030:1:exon

YOL036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL036W
product: uncharacterized protein
transcript id: NM_001183290.1
SIO_010081: YOL036W
subclass of: SO_0000673
so part of: YOL036W
location: <256745..>259030
location: region:256745-259030:1
so has part: feature:256745-259030:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256745-259030:1:exon

YOL036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL036W
note: hypothetical protein; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MEHQDSSPPRFRNSGSNRVTVYNGTTLPTMPKSATPTSSSTTVTTHLQNIKEEETNDDELTQVDRSSPRVLGRISSTSSSSSNIDLRDNLDMLHEIEKSNTNISLSAPNLHEELGVLSDKGNSKEELALLPPLPHTGEMEITPQFDINEAIFERDDISHSSRLEPDDVLTKLANSTRDATGEDQGFVVMTHGHDASTNDDSQLSATILDNQTSFDLSKALEMTSHSNISNIINSSGSEGRRSRTPVSNSTLKPNLSSPESAEREANTTSSSSTSDHGATMQYDPKKIITPIPVLPSSVREQQQNNAPLRERSRSNSSALASTLRDTIISGLPQNINSVERKLSRKSNRSRKNTVTFEDRLQKLPPLSTQISNQYAKVAPAENNIALHFHNLPTPVSNTQTPVTFQSESGLTGGEKKMPFLRRASSALLRKTSAKNCSNLTRTNTPTLSTSSTFESDLNARQPMLIRRSSTIDNKLPRRQLSCSKLYSRLNSDSKFANSSRASEEVLVSTPNDTEHVYRKTSLGSKIKRGFTRILSDSNNSKEILTLSPKSMVTTGPTELSFSSLSTVGGHPTTPVSKENDRVSIDGVSTFNRASTSLPESSTDDISPLREEGKINVPKRTSSRKILSKNSSKKNVLPEQQTKPSEIYLDKEALQSFVPVLSVTEGTHRINRSSLQTQSTIGLCITNLRNKEGMKLNAKEYVEILAQQQRKEDERYAVLERKFASCRWCSDKDLQYLKKKRISMNKIWSDYVRFYRGKLNNP
SIO_010081: YOL036W
subclass of: SO_0000673
so part of: YOL036W
location: 256745..259030
location: region:256745-259030:1
so has part: feature:256745-259030:1:exon

NP_014606.1
type: Protein
SIO_000068: ncbiprotein

S000005396
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256745-259030:1:exon

YNCO0007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR50
locus tag: YNCO0007W
so part of: sequence
location: 259489..259578
location: region:259489-259578:1
so has part: feature:259489-259578:1:exon
subclass of: SO_0000578

9164975
type: Gene
SIO_000068: ncbigene

position:259489:1
position: 259489
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:259578:1
position: 259578
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259489-259578:1:exon

YNCO0007W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR50
locus tag: YNCO0007W
product: SNR50
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position G867
transcript id: NR_132257.1
SIO_010081: YNCO0007W
subclass of: SO_0000673
so part of: YNCO0007W
location: 259489..259578
location: region:259489-259578:1
so has part: feature:259489-259578:1:exon

S000006441
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259489-259578:1:exon

YOL034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMC5
locus tag: YOL034W
so part of: sequence
location: <259923..>263204
location: region:259923-263204:1
so has part: feature:259923-263204:1:exon
subclass of: SO_0000010

854123
type: Gene
SIO_000068: ncbigene

position:259923:1
position: 259923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263204:1
position: 263204
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259923-263204:1:exon

YOL034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMC5
locus tag: YOL034W
product: DNA repair ATPase SMC5
transcript id: NM_001183288.1
SIO_010081: YOL034W
subclass of: SO_0000673
so part of: YOL034W
location: <259923..>263204
location: region:259923-263204:1
so has part: feature:259923-263204:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:259923-263204:1:exon

YOL034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMC5
locus tag: YOL034W
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:16793545]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21293191]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11927594]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11927594]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:21293191]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]
experiment: EXISTENCE:mutant phenotype:GO:0051304 chromosome separation [PMID:15793567]
experiment: EXISTENCE:mutant phenotype:GO:0071139 resolution of recombination intermediates [PMID:20159973]
experiment: EXISTENCE:physical interaction:GO:0000725 recombinational repair [PMID:19995966]
note: Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
codon start: 1
product: DNA repair ATPase SMC5
translation: MTSLIDLGRYVERTHHGEDTEPRSKRVKIAKPDLSSFQPGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDARDETIKITRIITRSKRRSDYLINDYQVSESVVKTLVAQLNIQLDNLCQFLSQERVEEFARLKSVKLLVETIRSIDASLLDVLDELRELQGNEQSLQKDLDFKKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHSQLLPYVKVKDHKEKLNIYKEEYERAKANLRAILKDKKPFANTKKTLENQVEELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDFLRSQEILAQTHLPEKSVFEDIDIKRKEIINKEGEIRDLISEIDAKANAINHEMRSIQRQAESKTKSLTTTDKIGILNQDQDLKEVRDAVLMVREHPEMKDKILEPPIMTVSAINAQFAAYLAQCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSDFITGDKRVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNGKILFKRIIHGNRLVDIKQSAYGSKQVFPTDVSIKQTNFYQGSIMSNEQKIRIENEIINLKNEYNDRKSTLDALSNQKSGYRHELSELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLKQRHLLSKMASSMKSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKKKFVKEMRDTPEFQSWMREIRSYDQDTKEKLNKVAEKYEEEGNFNLSFVQDVLDKLESEIAMVNHDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLEPKLDDIVSKISARFARLFNNVGSAGAVRLEKPKDYAEWKIEIMVKFRDNAPLKKLDSHTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLITPKLLTGLHYHEKMRIHCVMAGSWIPNPSEDPKMIHFGETSNYSFD
SIO_010081: YOL034W
subclass of: SO_0000673
so part of: YOL034W
location: 259923..263204
location: region:259923-263204:1
so has part: feature:259923-263204:1:exon

NP_014608.1
type: Protein
SIO_000068: ncbiprotein

S000005394
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259923-263204:1:exon

YOL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSE1
locus tag: YOL033W
so part of: sequence
location: <263475..>265085
location: region:263475-265085:1
so has part: feature:263475-265085:1:exon
subclass of: SO_0000010

854124
type: Gene
SIO_000068: ncbigene

position:263475:1
position: 263475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:265085:1
position: 265085
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263475-265085:1:exon

YOL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSE1
locus tag: YOL033W
product: glutamate--tRNA ligase MSE1
transcript id: NM_001183287.1
SIO_010081: YOL033W
subclass of: SO_0000673
so part of: YOL033W
location: <263475..>265085
location: region:263475-265085:1
so has part: feature:263475-265085:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263475-265085:1:exon

YOL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSE1
locus tag: YOL033W
EC number: 6.1.1.17
experiment: EXISTENCE:curator inference:GO:0070149 mitochondrial glutamyl-tRNA aminoacylation [PMID:7607232]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]
note: Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated
codon start: 1
product: glutamate--tRNA ligase MSE1
translation: MIMLRIPTRSYCSPSKLIKGVGLSPLKKSLLSKKIKEDIHPSLPVRTRFAPSPTGFLHLGSLRTALYNYLLARNTNGQFLLRLEDTDQKRLIEGAEENIYEILKWCNINYDETPIKQSERKLIYDKYVKILLSSGKAYRCFCSKERLNDLRHSAMELKPPSMASYDRCCAHLGEEEIKSKLAQGIPFTVRFKSPERYPTFTDLLHGQINLQPQVNFNDKRYDDLILVKSDKLPTYHLANVVDDHLMGITHVIRGEEWLPSTPKHIALYNAFGWACPKFIHIPLLTTVGDKKLSKRKGDMSISDLKRQGVLPEALINFCALFGWSPPRDLASKKHECFSMEELETIFNLNGLTKGNAKVDDKKLWFFNKHFLQKRILNPSTLRELVDDIMPSLESIYNTSTISREKVAKILLNCGGSLSRINDFHDEFYYFFEKPKYNDNDAVTKFLSKNESRHIAHLLKKLGQFQEGTDAQEVESMVETMYYENGFSRKVTYQAMRFALAGCHPGAKIAAMIDILGIKESNKRLSEGLQFLQREKK
SIO_010081: YOL033W
subclass of: SO_0000673
so part of: YOL033W
location: 263475..265085
location: region:263475-265085:1
so has part: feature:263475-265085:1:exon

NP_014609.1
type: Protein
SIO_000068: ncbiprotein

S000005393
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263475-265085:1:exon

YOL032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OPI10
locus tag: YOL032W
so part of: sequence
location: <265429..>266169
location: region:265429-266169:1
so has part: feature:265429-266169:1:exon
subclass of: SO_0000010

854125
type: Gene
SIO_000068: ncbigene

position:265429:1
position: 265429
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266169:1
position: 266169
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:265429-266169:1:exon

YOL032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OPI10
locus tag: YOL032W
product: Opi10p
transcript id: NM_001183286.1
SIO_010081: YOL032W
subclass of: SO_0000673
so part of: YOL032W
location: <265429..>266169
location: region:265429-266169:1
so has part: feature:265429-266169:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:265429-266169:1:exon

YOL032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OPI10
locus tag: YOL032W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006020 inositol metabolic process [PMID:16582425]
note: Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
codon start: 1
product: Opi10p
translation: MFAAIASGNPLQLSVEVPNSNGLQHTIVLSRTKPKLYSHITLFILPNVTFPQDYIATVYFKLSPQEEFKLFGYLSSEKPSAIFKVQIPSSKKDAGDTSDGLGEIDMDVDDGSGAADPFTDTNGSSSNNISELIIGISIEPREQGMMKLEEWKASMNAEAQKNNSLILSRPNLGIIRNITTAGQLAQVYPSLTQELAAKIVQHAYNYLSGFLDAQGNVPIKRFDTWWDKFRNRLANDGTFLDEVTKN
SIO_010081: YOL032W
subclass of: SO_0000673
so part of: YOL032W
location: 265429..266169
location: region:265429-266169:1
so has part: feature:265429-266169:1:exon

NP_014610.1
type: Protein
SIO_000068: ncbiprotein

S000005392
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:265429-266169:1:exon

YOL031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLS1
gene: SIL1
locus tag: YOL031C
gene synonym: SLS1
so part of: sequence
location: complement(<266264..>267529)
location: region:266264-267529:-1
so has part: feature:266264-267529:-1:exon
subclass of: SO_0000010

854126
type: Gene
SIO_000068: ncbigene

position:266264:-1
position: 266264
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:267529:-1
position: 267529
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:266264-267529:-1:exon

YOL031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLS1
gene: SIL1
locus tag: YOL031C
gene synonym: SLS1
product: Sil1p
transcript id: NM_001183285.1
SIO_010081: YOL031C
subclass of: SO_0000673
so part of: YOL031C
location: complement(<266264..>267529)
location: region:266264-267529:-1
so has part: feature:266264-267529:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:266264-267529:-1:exon

YOL031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLS1
gene: SIL1
locus tag: YOL031C
gene synonym: SLS1
experiment: EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:10958688]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:10958688]
note: Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein
codon start: 1
product: Sil1p
translation: MVRILPIILSALSSKLVASTILHSSIHSVPSGGEIISAEDLKELEISGNSICVDNRCYPKIFEPRHDWQPILPGQELPGGLDIRINMDTGLKEAKLNDEKNVGDNGSHELIVSSEDMKASPGDYEFSSDFKEMRNIIDSNPTLSSQDIARLEDSFDRIMEFAHDYKHGYKIITHEFALLANLSLNENLPLTLRELSTRVITSCLRNNPPVVEFINESFPNFKSKIMAALSNLNDSNHRSSNILIKRYLSILNELPVTSEDLPIYSTVVLQNVYERNNKDKQLQIKVLELISKILKADMYENDDTNLILFKRNAENWSSNLQEWANEFQEMVQNKSIDELHTRTFFDTLYNLKKIFKSDITINKGFLNWLAQQCKARQSNLDNGLQERDTEQDSFDKKLIDSRHLIFGNPMAHRIKNFRDEL
SIO_010081: YOL031C
subclass of: SO_0000673
so part of: YOL031C
location: complement(266264..267529)
location: region:266264-267529:-1
so has part: feature:266264-267529:-1:exon

NP_014611.1
type: Protein
SIO_000068: ncbiprotein

S000005391
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:266264-267529:-1:exon

YOL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAS5
locus tag: YOL030W
so part of: sequence
location: <268187..>269641
location: region:268187-269641:1
so has part: feature:268187-269641:1:exon
subclass of: SO_0000010

854127
type: Gene
SIO_000068: ncbigene

position:268187:1
position: 268187
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:269641:1
position: 269641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268187-269641:1:exon

YOL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAS5
locus tag: YOL030W
product: 1,3-beta-glucanosyltransferase
transcript id: NM_001183284.1
SIO_010081: YOL030W
subclass of: SO_0000673
so part of: YOL030W
location: <268187..>269641
location: region:268187-269641:1
so has part: feature:268187-269641:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:268187-269641:1:exon

YOL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAS5
locus tag: YOL030W
experiment: EXISTENCE:curator inference:GO:0006074 (1->3)-beta-D-glucan metabolic process [PMID:10769178|PMID:17397106]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]
experiment: EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106]
note: 1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall
codon start: 1
product: 1,3-beta-glucanosyltransferase
translation: MLLRSLTSAFVLSAGLAQAASSSNSSTPSIEIKGNAFFNSESGERFYIRGVDYQPGGSSNLTDPLADASVCDRDVPVLKDLGINTVRVYTVDNSQDHSHCMKLLQENGIYLILDVNTPTSAISRYDPACSYNADYLQNVFATIDTFADYDNVLGFFAGNEVINSVNTTNTATYVKAVVRDMKKYIKARKYRQIPVGYSAADIVANRQLAAEYFNCGDEADARIDMFGVNDYSWCGESSFVVSGYSTKMKLYQDYSVPVFLSEFGCNQVKSSRPFTEIEAIYSTQMSSVFSGGLVYEYSNETNNYGLVQIDGDKVTKLTDFENLKNEYSKVSNPEGNGGYSTSNNYSTCPDYEKGVWEANNTLPAMPSAASAYFTSGAGSPMGTGIATQQSCDAKDDDDEEDDDTSSSSSSSSSSSSSASSSSESSSSTSKASSSSPSASETSLLKSAASATSSSQSSSKSKGAAGIIEIPLIFRALAELYNLVL
SIO_010081: YOL030W
subclass of: SO_0000673
so part of: YOL030W
location: 268187..269641
location: region:268187-269641:1
so has part: feature:268187-269641:1:exon

NP_014612.1
type: Protein
SIO_000068: ncbiprotein

S000005390
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:268187-269641:1:exon

YOL029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL029C
so part of: sequence
location: complement(<269815..>270420)
location: region:269815-270420:-1
so has part: feature:269815-270420:-1:exon
subclass of: SO_0000010

854128
type: Gene
SIO_000068: ncbigene

position:269815:-1
position: 269815
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270420:-1
position: 270420
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:269815-270420:-1:exon

YOL029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL029C
product: uncharacterized protein
transcript id: NM_001183283.1
SIO_010081: YOL029C
subclass of: SO_0000673
so part of: YOL029C
location: complement(<269815..>270420)
location: region:269815-270420:-1
so has part: feature:269815-270420:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:269815-270420:-1:exon

YOL029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL029C
note: hypothetical protein; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
codon start: 1
product: uncharacterized protein
translation: MKPVTCCNQKNNIMPSLVPVCCSEKKIESDAKKSISKCCGDKEIYDSENRPITKEDGSWIPGSCKQCRSDPHSRNFCQSLSNKCSSSSFSSNSALSPDLNEQQTDVNYNSIKLPEICSCKNAQMNAASDAKRYLPISYTYQKIRQHMQKNKSIQEQLNPEDSTSISSALENIASGLHVRGQKVELQSIKDALHKMDKNVLE
SIO_010081: YOL029C
subclass of: SO_0000673
so part of: YOL029C
location: complement(269815..270420)
location: region:269815-270420:-1
so has part: feature:269815-270420:-1:exon

NP_014613.1
type: Protein
SIO_000068: ncbiprotein

S000005389
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:269815-270420:-1:exon

YOL028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YAP7
locus tag: YOL028C
so part of: sequence
location: complement(<270633..>271370)
location: region:270633-271370:-1
so has part: feature:270633-271370:-1:exon
subclass of: SO_0000010

854129
type: Gene
SIO_000068: ncbigene

position:270633:-1
position: 270633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271370:-1
position: 271370
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270633-271370:-1:exon

YOL028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YAP7
locus tag: YOL028C
product: Yap7p
transcript id: NM_001183282.1
SIO_010081: YOL028C
subclass of: SO_0000673
so part of: YOL028C
location: complement(<270633..>271370)
location: region:270633-271370:-1
so has part: feature:270633-271370:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270633-271370:-1:exon

YOL028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YAP7
locus tag: YOL028C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:20802496]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496]
note: Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
codon start: 1
product: Yap7p
translation: MRQRRSVVAVSVKPKGFKLGHKQGSMSTTSPPPSSPDGNVSTSGPSAIKLSKNWELPQRLKPGRKPKSKRGDASANNDGSSKIKKVQTSNQKDQMTTKDHENEGAKGHEGKSDDEGNGSGDENGVDSVEKRRRQNRDAQRAYRERRTTRIQVLEEKVEMLHNLVDDWQRKYKLLESEFSDTKENLQKSIALNNELQKALPLIVNTPFQQQPENPPDNPISILEMVENFKPIGAVSLKKGKLKAHC
SIO_010081: YOL028C
subclass of: SO_0000673
so part of: YOL028C
location: complement(270633..271370)
location: region:270633-271370:-1
so has part: feature:270633-271370:-1:exon

NP_014614.1
type: Protein
SIO_000068: ncbiprotein

S000005388
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270633-271370:-1:exon

YOL027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MKH1
gene: MDM38
locus tag: YOL027C
gene synonym: MKH1
so part of: sequence
location: complement(<272003..>273724)
location: region:272003-273724:-1
so has part: feature:272003-273724:-1:exon
subclass of: SO_0000010

854130
type: Gene
SIO_000068: ncbigene

position:272003:-1
position: 272003
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273724:-1
position: 273724
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272003-273724:-1:exon

YOL027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MKH1
gene: MDM38
locus tag: YOL027C
gene synonym: MKH1
product: ribosome-binding protein MDM38
transcript id: NM_001183281.1
SIO_010081: YOL027C
subclass of: SO_0000673
so part of: YOL027C
location: complement(<272003..>273724)
location: region:272003-273724:-1
so has part: feature:272003-273724:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272003-273724:-1:exon

YOL027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MKH1
gene: MDM38
locus tag: YOL027C
gene synonym: MKH1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15138253|PMID:16476776]
experiment: EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:20427570]
experiment: EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]
experiment: EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:20427570]
experiment: EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]
experiment: EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:15904662]
experiment: EXISTENCE:mutant phenotype:GO:0030007 cellular potassium ion homeostasis [PMID:15138253]
experiment: EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:16476776]
note: Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
codon start: 1
product: ribosome-binding protein MDM38
translation: MLNFASRASCVTRRQASLYFVKNQGPRLIASTIPSCHWPLRAQGVQPNYPLSLRFYSTDKSKSVTKPVAPTSTDAPAKPKETLMVKVKHALKHYANGTKLLGYEIKVSTKLLIKFAQGYELSRRERNQLRRTMGDVFRLIPFSAFLIIPFAELFLPFALKLFPNLLPSTYESGKDKQAKRNKLIEIRKKTSEFLHETLEESNLITYNTIENAEKKQKFLNFFRKLYSAKEGKIMTFQHDEISAIAQMFKNDSVLDNLSRPQLAAMSKFMSLRPFGNDNMLRYQIRSKLKDIMNDDKTIDYEGVESLSQEELYQACVSRGMKAYGVSKEDLVDNLKVWLELRLRQKIPSVLMVLSSTFTFGGLPKENYSKAFSPLAEKKETKSKYDDLLDLYYDGILQVLSSIPDPVYNVAKLDVSESKSSAAETEAEKQVAEKKIKTEEKPEETAIPKEEATAKESVIATTASAVTPKLVVVNEKAETAKTEEISQEKENAEPTDSAEATEAEEKKTSDDNEFKLNVLKEQEELIKKEEEEAKQRASREHVPDDINLDEEEEAKSVPPIPADQAAKTFVIKKD
SIO_010081: YOL027C
subclass of: SO_0000673
so part of: YOL027C
location: complement(272003..273724)
location: region:272003-273724:-1
so has part: feature:272003-273724:-1:exon

NP_014615.1
type: Protein
SIO_000068: ncbiprotein

S000005387
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272003-273724:-1:exon

YOL026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TOM13
gene: MIM1
locus tag: YOL026C
gene synonym: TOM13
so part of: sequence
location: complement(<274012..>274353)
location: region:274012-274353:-1
so has part: feature:274012-274353:-1:exon
subclass of: SO_0000010

854131
type: Gene
SIO_000068: ncbigene

position:274012:-1
position: 274012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:274353:-1
position: 274353
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274012-274353:-1:exon

YOL026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TOM13
gene: MIM1
locus tag: YOL026C
gene synonym: TOM13
product: Mim1p
transcript id: NM_001183280.1
SIO_010081: YOL026C
subclass of: SO_0000673
so part of: YOL026C
location: complement(<274012..>274353)
location: region:274012-274353:-1
so has part: feature:274012-274353:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274012-274353:-1:exon

YOL026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TOM13
gene: MIM1
locus tag: YOL026C
gene synonym: TOM13
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15608614|PMID:15326197]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:21825073|PMID:21825074]
experiment: EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:15608614|PMID:17974559]
note: Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex
codon start: 1
product: Mim1p
translation: MTEVVGFWESVSDDESEDKDCMEVQNTVSADESPLVQSLVSFVGSCSINLLLPFLNGMMLGFGELFAHELCWRFNWFNHRNKGYKVYPESRKIAALKEISSPGTRGRVASKFL
SIO_010081: YOL026C
subclass of: SO_0000673
so part of: YOL026C
location: complement(274012..274353)
location: region:274012-274353:-1
so has part: feature:274012-274353:-1:exon

NP_014616.1
type: Protein
SIO_000068: ncbiprotein

S000005386
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274012-274353:-1:exon

YNCO0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0008W
so part of: sequence
location: 274673..274773
location: region:274673-274773:1
so has part: feature:274673-274773:1:exon
subclass of: SO_0000663

854132
type: Gene
SIO_000068: ncbigene

position:274673:1
position: 274673
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:274773:1
position: 274773
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274673-274773:1:exon

YNCO0008W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0008W
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0008W
subclass of: SO_0000673
so part of: YNCO0008W
location: join(274673..274709,274729..274773)
location: region:274673-274773:1
so has part: feature:274673-274709:1:exon
so has part: feature:274729-274773:1:exon

S000006733
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274673-274709:1:exon

position:274709:1
position: 274709
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:274729-274773:1:exon

position:274729:1
position: 274729
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOL025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECM36
gene: LAG2
locus tag: YOL025W
gene synonym: ECM36
so part of: sequence
location: <274957..>276939
location: region:274957-276939:1
so has part: feature:274957-276939:1:exon
subclass of: SO_0000010

854133
type: Gene
SIO_000068: ncbigene

position:274957:1
position: 274957
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276939:1
position: 276939
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274957-276939:1:exon

YOL025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECM36
gene: LAG2
locus tag: YOL025W
gene synonym: ECM36
product: Lag2p
transcript id: NM_001183279.1
SIO_010081: YOL025W
subclass of: SO_0000673
so part of: YOL025W
location: <274957..>276939
location: region:274957-276939:1
so has part: feature:274957-276939:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274957-276939:1:exon

YOL025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECM36
gene: LAG2
locus tag: YOL025W
gene synonym: ECM36
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0051444 negative regulation of ubiquitin-protein transferase activity [PMID:19942853]
experiment: EXISTENCE:mutant phenotype:GO:0051444 negative regulation of ubiquitin-protein transferase activity [PMID:19763088]
note: Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
codon start: 1
product: Lag2p
translation: MSLHISKLIEQYRSTKDNDLKYMLLRQNFKINDIEDELAPLVNELLLPVLVEEQDMEILNLVSFQVLPDLVLSMISDPAAAQLGWVISLICDPLLNQSMIHANRSFVLIETLRNVLQKIENSPHLDYHQPVNSSLEFISKFIVEMKRHMCDVDAAQLSHSLSESNMLIYIESLNLLLKFSFFSDAASPSVMVTLPFDILNDVFTIAQDYSATNTNESIDRITEKLLLTSTQLTHPVDLENLCPKMKYNTLAAVSRIWYKFGPIVDKLFTNRLLPVLFPPQMGEECNVEDVLEIVHNFHPYFSIRRLKDNRPLLSDSTISQLREGLFGMLSILNDSLTRTQNENDHGSDNLIDSDDGFGSDNDPEQQAYLDELVSEGYDENMYDGDTDDEDADDINVEKNDEATKDITETNKILLIFSELHYPQEERFSELLVELQTKIAINTSLIDKILSKETTELPTHNGEIADLNEILNEVKGNKPIRKNVIFCTLAHTLSLQSGSELSVLQLSIEVIDHLLVKNHSNNITRGEQFQLIKLILPHLKTNKSFIDTLKAGNFTQKIDEGVTLRTMILSLLLQLFPLDYSMLGEILPTIARYSVRDKDLGVRDLSFQLLDQILRTYYNYLIGIDWEWYKDDFYQVLQETCIKKDINTNLLLQFPPYLPHD
SIO_010081: YOL025W
subclass of: SO_0000673
so part of: YOL025W
location: 274957..276939
location: region:274957-276939:1
so has part: feature:274957-276939:1:exon

NP_014617.1
type: Protein
SIO_000068: ncbiprotein

S000005385
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274957-276939:1:exon

YOL024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL024W
so part of: sequence
location: <277086..>277604
location: region:277086-277604:1
so has part: feature:277086-277604:1:exon
subclass of: SO_0000010

854134
type: Gene
SIO_000068: ncbigene

position:277086:1
position: 277086
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:277604:1
position: 277604
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:277086-277604:1:exon

YOL024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL024W
product: uncharacterized protein
transcript id: NM_001183278.1
SIO_010081: YOL024W
subclass of: SO_0000673
so part of: YOL024W
location: <277086..>277604
location: region:277086-277604:1
so has part: feature:277086-277604:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:277086-277604:1:exon

YOL024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL024W
note: hypothetical protein; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSKLSSYPHAADFINMEEPPKSKEFFDDLCAVPNLLKRRFPNSRRSTHYCEALNYSRKKLPVVLSKMTLQELRHNMSTFFLQEKDQINIYDTCKVIDMGDRVLLETMPPQPRDLFEKLHASKTNLVVQTAALDEPLLTVKAELQSSSFPQKSSLFLYEDYKKFIYQQLDMFS
SIO_010081: YOL024W
subclass of: SO_0000673
so part of: YOL024W
location: 277086..277604
location: region:277086-277604:1
so has part: feature:277086-277604:1:exon

NP_014618.1
type: Protein
SIO_000068: ncbiprotein

S000005384
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:277086-277604:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1511; Autonomously Replicating Sequence; replication capacity dependent upon Sum1p
so part of: sequence
location: 277530..277778
location: region:277530-277778:1
so has part: feature:277530-277778:1:region

S000118488
type: SGD
SIO_000068: sgd

position:277530:1
position: 277530
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:277778:1
position: 277778
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:277530-277778:1:region

YOL023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IFM1
locus tag: YOL023W
so part of: sequence
location: <278056..>280086
location: region:278056-280086:1
so has part: feature:278056-280086:1:exon
subclass of: SO_0000010

854135
type: Gene
SIO_000068: ncbigene

position:278056:1
position: 278056
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280086:1
position: 280086
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278056-280086:1:exon

YOL023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IFM1
locus tag: YOL023W
product: translation initiation factor 2
transcript id: NM_001183277.1
SIO_010081: YOL023W
subclass of: SO_0000673
so part of: YOL023W
location: <278056..>280086
location: region:278056-280086:1
so has part: feature:278056-280086:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278056-280086:1:exon

YOL023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IFM1
locus tag: YOL023W
experiment: EXISTENCE:curator inference:GO:0070124 mitochondrial translational initiation [PMID:15935987]
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:12729623]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:15935987]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:12729623]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:11914276|PMID:14576278|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1935960]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1935960]
note: Mitochondrial translation initiation factor 2
codon start: 1
product: translation initiation factor 2
translation: MLRRHGLFWLKTCPRLNVLLNQSIPIPHLLHSRDICQQRWYAKGKRRNQISKKELKPLNFSIPNYISVNKLANLLNCRVERLIKDLTALGFENITTTYILSKEYVELILQEYNFALPNLSTSTNLDNVYDELKSPVNPKLLTKRAPVVTIMGHVDHGKTTIIDYLRKSSVVAQEHGGITQHIGAFQITAPKSGKKITFLDTPGHAAFLKMRERGANITDIIVLVVSVEDSLMPQTLEAIKHAKNSGNEMIIAITKIDRIPQPKEREKKIEKVINDLIVQGIPVEKIGGDVQVIPISAKTGENMDLLEESIVLLSEVMDIRAENSPKTIAEGWIIESQVKKQVGNVATVLVKKGTLQKGKILICGNTFCKIKNLIDDKGIPILKATPSYATEVLGWKDVPHVGDEVIQVKSEAIAKKFISKRQDLIEVQKNSSIVEKLNEERALAKEQHLNKELEHENTVQEHEQNTGPKLINYIIKCDVSGSAEAVSESISSLGNDEVRCNVISSSVGIPTESDLKMAQITESTILCFNLGNLPSEVINNRAGIKIKQYNVIYKLIEDVTETLTENLKPIFEKKIVSTVDVRETFDFRLKKKIIRIAGCKVNNGVIKKNSLVQVVRGPNEDVIFDGKISTLKHNKDDVAEVSKGHECGITFESGFEGFKPGDKILVYENVRVPRYL
SIO_010081: YOL023W
subclass of: SO_0000673
so part of: YOL023W
location: 278056..280086
location: region:278056-280086:1
so has part: feature:278056-280086:1:exon

NP_014619.1
type: Protein
SIO_000068: ncbiprotein

S000005383
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278056-280086:1:exon

YOL022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TSR4
locus tag: YOL022C
so part of: sequence
location: complement(<280272..>281498)
location: region:280272-281498:-1
so has part: feature:280272-281498:-1:exon
subclass of: SO_0000010

854136
type: Gene
SIO_000068: ncbigene

position:280272:-1
position: 280272
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281498:-1
position: 281498
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280272-281498:-1:exon

YOL022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TSR4
locus tag: YOL022C
product: Tsr4p
transcript id: NM_001183276.2
SIO_010081: YOL022C
subclass of: SO_0000673
so part of: YOL022C
location: complement(<280272..>281498)
location: region:280272-281498:-1
so has part: feature:280272-281498:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280272-281498:-1:exon

YOL022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TSR4
locus tag: YOL022C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:31182640]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:31062022|PMID:31182640]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:31062022]
experiment: EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:31062022|PMID:31182640]
experiment: EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:31182640]
note: Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2
codon start: 1
product: Tsr4p
translation: MSKIEELPPSDTDDHSYSSKPGDVFLAFVDAPVKETDDILVEDSFIGGEPKWLHPDSEPPAELLKCGACKSADNMKLLLQAFSPLDDEQMSAIQQRLGINNMSYINPQDDRVLYVFLCTECQRKGNSVRCIRGVKKNKNVDSLSEKMASTSLEKDFQINPFDLSNNSDSKCNAFSSNPFGGANANPFGADSINSNISQSKDEGKKKESATVSAKTARKLHDLQKDKEYDGNKCFKSCLLYVEEETFKNKKPAHLQLPKNLKIDKEALDLTGDEDLEKDPIKLDPRTEKLSKFLDDDTFQKFQEVVGYNPLQVLRYDLGGKPLLYAETKVDILSTVPRPGYNPSSQRIFEMQLMPKMIFDLEEVVSVDNGMEWGTILVFTDVENYMPEFDEHGVGYVEECVKVQWESRT
SIO_010081: YOL022C
subclass of: SO_0000673
so part of: YOL022C
location: complement(280272..281498)
location: region:280272-281498:-1
so has part: feature:280272-281498:-1:exon

NP_014620.1
type: Protein
SIO_000068: ncbiprotein

S000005382
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280272-281498:-1:exon

YNCO0009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF17
locus tag: YNCO0009W
so part of: sequence
location: 282164..282234
location: region:282164-282234:1
so has part: feature:282164-282234:1:exon
subclass of: SO_0000663

854137
type: Gene
SIO_000068: ncbigene

position:282164:1
position: 282164
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:282234:1
position: 282234
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282164-282234:1:exon

YNCO0009W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF17
locus tag: YNCO0009W
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons
SIO_010081: YNCO0009W
subclass of: SO_0000673
so part of: YNCO0009W
location: 282164..282234
location: region:282164-282234:1
so has part: feature:282164-282234:1:exon

S000006587
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282164-282234:1:exon

YOL021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MTR17
alternative label: RRP44
gene: DIS3
locus tag: YOL021C
gene synonym: MTR17; RRP44
so part of: sequence
location: complement(<282421..>285426)
location: region:282421-285426:-1
so has part: feature:282421-285426:-1:exon
subclass of: SO_0000010

854138
type: Gene
SIO_000068: ncbigene

position:282421:-1
position: 282421
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:285426:-1
position: 285426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282421-285426:-1:exon

YOL021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MTR17
alternative label: RRP44
gene: DIS3
locus tag: YOL021C
gene synonym: MTR17; RRP44
product: exosome catalytic subunit DIS3
transcript id: NM_001183275.1
SIO_010081: YOL021C
subclass of: SO_0000673
so part of: YOL021C
location: complement(<282421..>285426)
location: region:282421-285426:-1
so has part: feature:282421-285426:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282421-285426:-1:exon

YOL021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MTR17
alternative label: RRP44
gene: DIS3
locus tag: YOL021C
gene synonym: MTR17; RRP44
experiment: EXISTENCE:curator inference:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:17643380]
experiment: EXISTENCE:direct assay:GO:0000175 3'-5'-exoribonuclease activity [PMID:17173052|PMID:17643380]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:19060886|PMID:19060898|PMID:19129231]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9562621|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:15935758|PMID:17643380]
experiment: EXISTENCE:genetic interaction:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15145828]
experiment: EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:17643380]
experiment: EXISTENCE:mutant phenotype:GO:0000175 3'-5'-exoribonuclease activity [PMID:17173052|PMID:17643380]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:9390555]
experiment: EXISTENCE:mutant phenotype:GO:0004521 endoribonuclease activity [PMID:19060886|PMID:19129231]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]
experiment: EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:10508172]
experiment: EXISTENCE:mutant phenotype:GO:0043628 regulatory ncRNA 3'-end processing [PMID:11352936]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:11030620]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16431988|PMID:18940861]
experiment: EXISTENCE:mutant phenotype:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:17643380]
experiment: EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]
note: Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress
codon start: 1
product: exosome catalytic subunit DIS3
translation: MSVPAIAPRRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNDRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDIDDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK
SIO_010081: YOL021C
subclass of: SO_0000673
so part of: YOL021C
location: complement(282421..285426)
location: region:282421-285426:-1
so has part: feature:282421-285426:-1:exon

NP_014621.1
type: Protein
SIO_000068: ncbiprotein

S000005381
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282421-285426:-1:exon

YOL020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HPG2
alternative label: LTG3
alternative label: SAB2
alternative label: SCM2
alternative label: TAP2
gene: TAT2
locus tag: YOL020W
gene synonym: HPG2; LTG3; SAB2; SCM2; TAP2
so part of: sequence
location: <286172..>287950
location: region:286172-287950:1
so has part: feature:286172-287950:1:exon
subclass of: SO_0000010

854139
type: Gene
SIO_000068: ncbigene

position:286172:1
position: 286172
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:287950:1
position: 287950
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286172-287950:1:exon

YOL020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HPG2
alternative label: LTG3
alternative label: SAB2
alternative label: SCM2
alternative label: TAP2
gene: TAT2
locus tag: YOL020W
gene synonym: HPG2; LTG3; SAB2; SCM2; TAP2
product: aromatic amino acid transmembrane transporter TAT2
transcript id: NM_001183274.1
SIO_010081: YOL020W
subclass of: SO_0000673
so part of: YOL020W
location: <286172..>287950
location: region:286172-287950:1
so has part: feature:286172-287950:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:286172-287950:1:exon

YOL020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HPG2
alternative label: LTG3
alternative label: SAB2
alternative label: SCM2
alternative label: TAP2
gene: TAT2
locus tag: YOL020W
gene synonym: HPG2; LTG3; SAB2; SCM2; TAP2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12810702|PMID:30660361]
experiment: EXISTENCE:direct assay:GO:0015173 aromatic amino acid transmembrane transporter activity [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0015801 aromatic amino acid transport [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:35031272]
experiment: EXISTENCE:mutant phenotype:GO:0005300 high-affinity tryptophan transmembrane transporter activity [PMID:7523855|PMID:35031272]
experiment: EXISTENCE:mutant phenotype:GO:0015827 tryptophan transport [PMID:7523855|PMID:35031272]
note: High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance
codon start: 1
product: aromatic amino acid transmembrane transporter TAT2
translation: MTEDFISSVKRSNEELKERKSNFGFVEYKSKQLTSSSSHNSNSSHHDDDNQHGKRNIFQRCVDSFKSPLDGSFDTSNLKRTLKPRHLIMIAIGGSIGTGLFVGSGKAIAEGGPLGVVIGWAIAGSQIIGTIHGLGEITVRFPVVGAFANYGTRFLDPSISFVVSTIYVLQWFFVLPLEIIAAAMTVQYWNSSIDPVIWVAIFYAVIVSINLFGVRGFGEAEFAFSTIKAITVCGFIILCVVLICGGGPDHEFIGAKYWHDPGCLANGFPGVLSVLVVASYSLGGIEMTCLASGETDPKGLPSAIKQVFWRILFFFLISLTLVGFLVPYTNQNLLGGSSVDNSPFVIAIKLHHIKALPSIVNAVILISVLSVGNSCIFASSRTLCSMAHQGLIPWWFGYIDRAGRPLVGIMANSLFGLLAFLVKSGSMSEVFNWLMAIAGLATCIVWLSINLSHIRFRLAMKAQGKSLDELEFVSAVGIWGSAYSALINCLILIAQFYCSLWPIGGWTSGKERAKIFFQNYLCALIMLFIFIVHKIYYKCQTGKWWGVKALKDIDLETDRKDIDIEIVKQEIAEKKMYLDSRPWYVRQFHFWC
SIO_010081: YOL020W
subclass of: SO_0000673
so part of: YOL020W
location: 286172..287950
location: region:286172-287950:1
so has part: feature:286172-287950:1:exon

NP_014622.1
type: Protein
SIO_000068: ncbiprotein

S000005380
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:286172-287950:1:exon

YNCO0010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUP3
locus tag: YNCO0010W
so part of: sequence
location: 288192..288280
location: region:288192-288280:1
so has part: feature:288192-288280:1:exon
subclass of: SO_0000663

854140
type: Gene
SIO_000068: ncbigene

position:288192:1
position: 288192
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:288280:1
position: 288280
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288192-288280:1:exon

YNCO0010W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUP3
locus tag: YNCO0010W
product: tRNA-Tyr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations
SIO_010081: YNCO0010W
subclass of: SO_0000673
so part of: YNCO0010W
location: join(288192..288230,288245..288280)
location: region:288192-288280:1
so has part: feature:288192-288230:1:exon
so has part: feature:288245-288280:1:exon

S000006785
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288192-288230:1:exon

position:288230:1
position: 288230
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:288245-288280:1:exon

position:288245:1
position: 288245
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOL019W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL019W-A
so part of: sequence
location: <288420..>288572
location: region:288420-288572:1
so has part: feature:288420-288572:1:exon
subclass of: SO_0000010

1466477
type: Gene
SIO_000068: ncbigene

position:288420:1
position: 288420
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:288572:1
position: 288572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288420-288572:1:exon

YOL019W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL019W-A
product: uncharacterized protein
transcript id: NM_001184622.1
SIO_010081: YOL019W-A
subclass of: SO_0000673
so part of: YOL019W-A
location: <288420..>288572
location: region:288420-288572:1
so has part: feature:288420-288572:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288420-288572:1:exon

YOL019W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL019W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MSNTFVAVEFSWLYAISLILPCETIRVAWAPKRAYHGTSEEKRRLAPADI
SIO_010081: YOL019W-A
subclass of: SO_0000673
so part of: YOL019W-A
location: 288420..288572
location: region:288420-288572:1
so has part: feature:288420-288572:1:exon

NP_878165.1
type: Protein
SIO_000068: ncbiprotein

S000028707
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288420-288572:1:exon

YOL019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOS7
locus tag: YOL019W
so part of: sequence
location: <288898..>290553
location: region:288898-290553:1
so has part: feature:288898-290553:1:exon
subclass of: SO_0000010

854141
type: Gene
SIO_000068: ncbigene

position:288898:1
position: 288898
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:290553:1
position: 290553
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288898-290553:1:exon

YOL019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOS7
locus tag: YOL019W
product: Tos7p
transcript id: NM_001183273.1
SIO_010081: YOL019W
subclass of: SO_0000673
so part of: YOL019W
location: <288898..>290553
location: region:288898-290553:1
so has part: feature:288898-290553:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288898-290553:1:exon

YOL019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOS7
locus tag: YOL019W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:33002606]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33002606|PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication
codon start: 1
product: Tos7p
translation: MKKNSSVVFFLVGLSQFVTMAFLIIGSITAPIFKQIGYSKYDEITYGTFGYCKEGSCSKASYNYHPDELSDSDSNWKLNSNARSILGKIIFITPIAAGLNFLGFLCTIMSVLLINVLSSDRVGSASAIMFFVNLTFSTLGFLSASLICIVVFLLFYPHVTWCSWVLIPGAALSLLVIPLIFSAYSRSSGSRDDDETEELEEKGMLLNDPYLSSKSGRFDIDADSEANLRGDSRTNLLGDNFKNGTNITVVPDIISHNQDPKLSNITTSTTSDISTFDKEAKDMENSNGSGLNEEEDDGMAYDKRRSTSTYSVIESESGLKNGSVSNNYVRNNGSNTSNNINYKVPLGKTEISSSASLASSDYSQREVIPHRNPSRLLNDIMETSFNEPNDSHINSMSSYNDKDSTLTSISQRGVNPEVYNQMPRETAAGPANIRPYAGQPHPAPLVYPQQRLQPQQQQPQQQYHQYNLYQRTTPAGPDPSNVILQSNPYFNVAPNQVPQHRNPVPGVGFAPNPLPNQSPITQGYKPAYKRRMQNKNLPRATTSLNNPYGFR
SIO_010081: YOL019W
subclass of: SO_0000673
so part of: YOL019W
location: 288898..290553
location: region:288898-290553:1
so has part: feature:288898-290553:1:exon

NP_014623.1
type: Protein
SIO_000068: ncbiprotein

S000005379
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288898-290553:1:exon

YOL018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TLG2
locus tag: YOL018C
so part of: sequence
location: complement(<290881..>292074)
location: region:290881-292074:-1
so has part: feature:290881-292074:-1:exon
subclass of: SO_0000010

854142
type: Gene
SIO_000068: ncbigene

position:290881:-1
position: 290881
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292074:-1
position: 292074
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290881-292074:-1:exon

YOL018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TLG2
locus tag: YOL018C
product: Tlg2p
transcript id: NM_001183272.1
SIO_010081: YOL018C
subclass of: SO_0000673
so part of: YOL018C
location: complement(<290881..>292074)
location: region:290881-292074:-1
so has part: feature:290881-292074:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:290881-292074:-1:exon

YOL018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TLG2
locus tag: YOL018C
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11739407]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:9427746|PMID:9565594]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11739407]
experiment: EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:9565594]
experiment: EXISTENCE:genetic interaction:GO:0006673 inositol phosphoceramide metabolic process [PMID:18753406]
experiment: EXISTENCE:genetic interaction:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:18753406]
experiment: EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:18753406]
experiment: EXISTENCE:genetic interaction:GO:0032527 protein exit from endoplasmic reticulum [PMID:18753406]
experiment: EXISTENCE:mutant phenotype:GO:0006673 inositol phosphoceramide metabolic process [PMID:18753406]
experiment: EXISTENCE:mutant phenotype:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:18753406]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9427746]
experiment: EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:22753847]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10545112]
experiment: EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]
note: Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
codon start: 1
product: Tlg2p
translation: MFRDRTNLFLSYRRTFPHNITFSSGKAPLGDDQDIEMGTYPMMNMSHDISARLTDERKNKHENHSDALPPIFIDIAQDVDDYLLEVRRLSEQLAKVYRKNSLPGFEDKSHDEALIEDLSFKVIQMLQKCYAVMKRLKTIYNSQFVDGKQLSREELIILDNLQKIYAEKIQTESNKFRVLQNNYLKFLNKDDLKPIRNKASAENTLLLDDEEEEAAREKREGLDIEDYSKRTLQRQQQLHDTSAEAYLRERDEEITQLARGVLEVSTIFREMQDLVVDQGTIVDRIDYNLENTVVELKSADKELNKATHYQKRTQKCKVILLLTLCVIALFFFVMLKPHGGGSGGRNNGSNKYNNDDNKTVNNSHDDGSNTHINDEESNLPSIVEVTESENDALDDLL
SIO_010081: YOL018C
subclass of: SO_0000673
so part of: YOL018C
location: complement(290881..292074)
location: region:290881-292074:-1
so has part: feature:290881-292074:-1:exon

NP_014624.1
type: Protein
SIO_000068: ncbiprotein

S000005378
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:290881-292074:-1:exon

YOL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ESC8
locus tag: YOL017W
so part of: sequence
location: <292529..>294673
location: region:292529-294673:1
so has part: feature:292529-294673:1:exon
subclass of: SO_0000010

854143
type: Gene
SIO_000068: ncbigene

position:292529:1
position: 292529
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:294673:1
position: 294673
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292529-294673:1:exon

YOL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ESC8
locus tag: YOL017W
product: Esc8p
transcript id: NM_001183271.1
SIO_010081: YOL017W
subclass of: SO_0000673
so part of: YOL017W
location: <292529..>294673
location: region:292529-294673:1
so has part: feature:292529-294673:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292529-294673:1:exon

YOL017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ESC8
locus tag: YOL017W
experiment: EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:12399377]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:12399377]
note: Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
codon start: 1
product: Esc8p
translation: MTEIIDLDLVDDFIKKPMVKQQKNQSSKPRVKRRGQLTFDDFRNIKIVEEPVVLSHNSSIDESLDAATQNTKKREKYEGTCDEEMKTKEMEANMASKYSNIKTHSNDTNKVESISEHTTSNNRPLNTLNWSPNIPLRYSDFAKFMSDETVTESNWAPPLCTPLPYAGDVMKILSFIVKFKWVFSDDLLNLSFQDVEIGLELKVAGHSAKNIRICQDKMNLLFCSLLRLLFCSEKRADNQTHRNFTLKRFLSLKNPYGKLVGKLRSLIQEWGLPKEWRGNSDILSTLNFNGGGLLTMEPLDRIILLRCMIDWNCSYSALFHNEIQRLTHLKGDTGFNHQTFHASRFAMCGANNILDSCEVLCSLMSQKLENRKKRKPSDKGKLSKINSQMKFLKGVRKSLSEKVTTDRLRAAVKINEEWGEYFANEFTHTPIDDPTVDEIYKLRTSEFMIARIPRVGDFYLPPFWIGNECSSVNTSYSFNDMSTYLNYFVKFKEEGTKILPAKTAQNENKCQLKLIYRNTPACIRNLQFNDVHFAEVPHWFEVAGDSNSLSNFIEYLESLSSLTENDTDDTKKGIDNLIEFLKIFSIFINETIQRITAAPTGSTEGRHLRTSSQRRTTVHYSSDVNGDVSEESENEVDIDVSDDYDSEYLSEENTLTRKGEDRTDKSFGKRELHNGAKDCDRNCDDIEIFSEPVRQLQDNSREKRSLRRNARKGL
SIO_010081: YOL017W
subclass of: SO_0000673
so part of: YOL017W
location: 292529..294673
location: region:292529-294673:1
so has part: feature:292529-294673:1:exon

NP_014625.1
type: Protein
SIO_000068: ncbiprotein

S000005377
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292529-294673:1:exon

YOL016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CMK2
locus tag: YOL016C
so part of: sequence
location: complement(<294777..>296120)
location: region:294777-296120:-1
so has part: feature:294777-296120:-1:exon
subclass of: SO_0000010

854144
type: Gene
SIO_000068: ncbigene

position:294777:-1
position: 294777
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296120:-1
position: 296120
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:294777-296120:-1:exon

YOL016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CMK2
locus tag: YOL016C
product: calmodulin-dependent protein kinase CMK2
transcript id: NM_001183270.1
SIO_010081: YOL016C
subclass of: SO_0000673
so part of: YOL016C
location: complement(<294777..>296120)
location: region:294777-296120:-1
so has part: feature:294777-296120:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:294777-296120:-1:exon

YOL016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CMK2
locus tag: YOL016C
EC number: 2.7.11.17
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004683 calmodulin-dependent protein kinase activity [PMID:2061341]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:2061341|PMID:16319894]
note: Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
codon start: 1
product: calmodulin-dependent protein kinase CMK2
translation: MPKESEVINSEFHVDVQDPERLNGHPVAKFINKLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDVKKGFSLRKKLRDAIEIVKLNNRIKRLRNMYSLGDDGDNDIEENSLNESLLDGVTHSLDDLRLQSQKKGGELTEEQMKLKSALTKDAFVQIVKAATKNKHKVLAGEEEDDSKKTLHDDRESKSED
SIO_010081: YOL016C
subclass of: SO_0000673
so part of: YOL016C
location: complement(294777..296120)
location: region:294777-296120:-1
so has part: feature:294777-296120:-1:exon

NP_014626.1
type: Protein
SIO_000068: ncbiprotein

S000005376
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:294777-296120:-1:exon

YOL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRC10
locus tag: YOL015W
so part of: sequence
location: <297078..>298838
location: region:297078-298838:1
so has part: feature:297078-298838:1:exon
subclass of: SO_0000010

854145
type: Gene
SIO_000068: ncbigene

position:297078:1
position: 297078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:298838:1
position: 298838
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297078-298838:1:exon

YOL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRC10
locus tag: YOL015W
product: Irc10p
transcript id: NM_001183269.1
SIO_010081: YOL015W
subclass of: SO_0000673
so part of: YOL015W
location: <297078..>298838
location: region:297078-298838:1
so has part: feature:297078-298838:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:297078-298838:1:exon

YOL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRC10
locus tag: YOL015W
experiment: EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:24390141]
note: hypothetical protein; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci
codon start: 1
product: Irc10p
translation: MFIEYSRLPGFESINISFSRGMLRLAKFTNFATYKQKLEYFRLLAGSNKYIQRISVADFERHPDEINYIYIILISILQMEECMPVLVLCPTVYWVRFHWPGKCSVNSLNFTNETLKSAFHAVFTPYFALMKKVLGRIKNNMLLFAEPHANLNNLFVKHFHDLIYKSVKDEKTGEAILYLRTNVNVPNVFIDDKRAVFHGDGMKIGKFTGKFLCFSFKRTIRWSKLDSVDSFAVTTVNYRVSVNWEKTPRKTFLSLDSDTKNLHYISKKILNKKGKNATTSKTTKSSCTSENVCDDKTFSVEFPLTTSAKTEYLLRSNFSLEKINESNNPTLQELTLNRTHRLYRSNFRNEQSTTQRKFEKIGRTVSTDSGNKLLTFPEQKATRDSNPFSIELTHATVISSDESALKDTTNQAIAEMQRITPAIAKTISRRTANWVCSNPAPDPYGEPSTWSRILTPNLKIISESSPYYPVHLASPNSTFSRDQSVRSVVMRRSSVCVEKQNSFFRNYEHFKNILSRRTIKVKTSCPRLSVDVSDNKRENLSQEHLILPNKSREKVNRFKNCLHRVAEALRAAKENWDQHNPRNSIH
SIO_010081: YOL015W
subclass of: SO_0000673
so part of: YOL015W
location: 297078..298838
location: region:297078-298838:1
so has part: feature:297078-298838:1:exon

NP_014627.1
type: Protein
SIO_000068: ncbiprotein

S000005375
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:297078-298838:1:exon

YOL014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOL014W
so part of: sequence
location: <299693..>300067
location: region:299693-300067:1
so has part: feature:299693-300067:1:exon
subclass of: SO_0000010

854146
type: Gene
SIO_000068: ncbigene

position:299693:1
position: 299693
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300067:1
position: 300067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:299693-300067:1:exon

YOL014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOL014W
product: uncharacterized protein
transcript id: NM_001183268.1
SIO_010081: YOL014W
subclass of: SO_0000673
so part of: YOL014W
location: <299693..>300067
location: region:299693-300067:1
so has part: feature:299693-300067:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:299693-300067:1:exon

YOL014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOL014W
note: hypothetical protein; mCherry fusion protein localizes to the cytosol and nucleus
codon start: 1
product: uncharacterized protein
translation: MRPHHFFCGNMGVMYTAMSGYETEDAQAYWACGRAYESAFATLTKKVPGTTFSADMPTSTWHGVLDCGYSSSINVAENKSSPIDYWNCGRTYARNYALSDALSLKPTNMLQYFLLVLFFICIIL
SIO_010081: YOL014W
subclass of: SO_0000673
so part of: YOL014W
location: 299693..300067
location: region:299693-300067:1
so has part: feature:299693-300067:1:exon

NP_014628.1
type: Protein
SIO_000068: ncbiprotein

S000005374
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:299693-300067:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(300683..301021)
location: region:300683-301021:-1
so has part: feature:300683-301021:-1:region

S000007152
type: SGD
SIO_000068: sgd

position:300683:-1
position: 300683
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:301021:-1
position: 301021
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:300683-301021:-1:region

YOL013W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOL013W-B
locus tag: YOL013W-A
gene synonym: YOL013W-B
so part of: sequence
location: <301047..>301238
location: region:301047-301238:1
so has part: feature:301047-301238:1:exon
subclass of: SO_0000010

854147
type: Gene
SIO_000068: ncbigene

position:301047:1
position: 301047
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301238:1
position: 301238
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301047-301238:1:exon

YOL013W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOL013W-B
locus tag: YOL013W-A
gene synonym: YOL013W-B
product: uncharacterized protein
transcript id: NM_001184640.1
SIO_010081: YOL013W-A
subclass of: SO_0000673
so part of: YOL013W-A
location: <301047..>301238
location: region:301047-301238:1
so has part: feature:301047-301238:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:301047-301238:1:exon

YOL013W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOL013W-B
locus tag: YOL013W-A
gene synonym: YOL013W-B
note: hypothetical protein; identified by SAGE
codon start: 1
product: uncharacterized protein
translation: MMCIINSESFHGSQKRSGVWSSGMILALGDFLINRGTKHARGPGFNSQLAPFFTIEKYSVRRS
SIO_010081: YOL013W-A
subclass of: SO_0000673
so part of: YOL013W-A
location: 301047..301238
location: region:301047-301238:1
so has part: feature:301047-301238:1:exon

NP_878166.1
type: Protein
SIO_000068: ncbiprotein

S000028811
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301047-301238:1:exon

YNCO0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0011W
so part of: sequence
location: 301097..301198
location: region:301097-301198:1
so has part: feature:301097-301198:1:exon
subclass of: SO_0000663

854148
type: Gene
SIO_000068: ncbigene

position:301097:1
position: 301097
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:301198:1
position: 301198
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301097-301198:1:exon

YNCO0011W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0011W
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin
SIO_010081: YNCO0011W
subclass of: SO_0000673
so part of: YNCO0011W
location: join(301097..301132,301163..301198)
location: region:301097-301198:1
so has part: feature:301097-301132:1:exon
so has part: feature:301163-301198:1:exon

S000006687
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301097-301132:1:exon

position:301132:1
position: 301132
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:301163-301198:1:exon

position:301163:1
position: 301163
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOL013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DER3
gene: HRD1
locus tag: YOL013C
gene synonym: DER3
so part of: sequence
location: complement(<301380..>303035)
location: region:301380-303035:-1
so has part: feature:301380-303035:-1:exon
subclass of: SO_0000010

854149
type: Gene
SIO_000068: ncbigene

position:301380:-1
position: 301380
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:303035:-1
position: 303035
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301380-303035:-1:exon

YOL013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DER3
gene: HRD1
locus tag: YOL013C
gene synonym: DER3
product: E3 ubiquitin-protein ligase HRD1
transcript id: NM_001183267.1
SIO_010081: YOL013C
subclass of: SO_0000673
so part of: YOL013C
location: complement(<301380..>303035)
location: region:301380-303035:-1
so has part: feature:301380-303035:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:301380-303035:-1:exon

YOL013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DER3
gene: HRD1
locus tag: YOL013C
gene synonym: DER3
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11139575|PMID:11146622]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:27831485]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11139575|PMID:9437001]
experiment: EXISTENCE:direct assay:GO:0030970 retrograde protein transport, ER to cytosol [PMID:27321670]
experiment: EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:27321670|PMID:31713515]
experiment: EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11146622]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:11146622]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:17035235|PMID:22298424|PMID:11146622]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:22298424]
experiment: EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]
note: Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
codon start: 1
product: E3 ubiquitin-protein ligase HRD1
translation: MVPENRRKQLAIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLIPFRMPMMLLKDVVWDILALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQHI
SIO_010081: YOL013C
subclass of: SO_0000673
so part of: YOL013C
location: complement(301380..303035)
location: region:301380-303035:-1
so has part: feature:301380-303035:-1:exon

NP_014630.1
type: Protein
SIO_000068: ncbiprotein

S000005373
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301380-303035:-1:exon

YOL012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HTA3
gene: HTZ1
locus tag: YOL012C
gene synonym: HTA3
so part of: sequence
location: complement(<303579..>303983)
location: region:303579-303983:-1
so has part: feature:303579-303983:-1:exon
subclass of: SO_0000010

854150
type: Gene
SIO_000068: ncbigene

position:303579:-1
position: 303579
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:303983:-1
position: 303983
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:303579-303983:-1:exon

YOL012C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HTA3
gene: HTZ1
locus tag: YOL012C
gene synonym: HTA3
product: histone H2AZ
transcript id: NM_001183266.1
SIO_010081: YOL012C
subclass of: SO_0000673
so part of: YOL012C
location: complement(<303579..>303983)
location: region:303579-303983:-1
so has part: feature:303579-303983:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:303579-303983:-1:exon

YOL012C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HTA3
gene: HTZ1
locus tag: YOL012C
gene synonym: HTA3
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11081628|PMID:11090616]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11081628]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11081628]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11090616]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:21357739]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11081628]
experiment: EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]
note: Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling
codon start: 1
product: histone H2AZ
translation: MSGKAHGGKGKSGAKDSGSLRSQSSSARAGLQFPVGRIKRYLKRHATGRTRVGSKAAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDDELDSLIRATIASGGVLPHINKALLLKVEKKGSKK
SIO_010081: YOL012C
subclass of: SO_0000673
so part of: YOL012C
location: complement(303579..303983)
location: region:303579-303983:-1
so has part: feature:303579-303983:-1:exon

NP_014631.1
type: Protein
SIO_000068: ncbiprotein

S000005372
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:303579-303983:-1:exon

YOL011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PLB3
locus tag: YOL011W
so part of: sequence
location: <305349..>307409
location: region:305349-307409:1
so has part: feature:305349-307409:1:exon
subclass of: SO_0000010

854151
type: Gene
SIO_000068: ncbigene

position:305349:1
position: 305349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:307409:1
position: 307409
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:305349-307409:1:exon

YOL011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PLB3
locus tag: YOL011W
product: lysophospholipase
transcript id: NM_001183265.1
SIO_010081: YOL011W
subclass of: SO_0000673
so part of: YOL011W
location: <305349..>307409
location: region:305349-307409:1
so has part: feature:305349-307409:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:305349-307409:1:exon

YOL011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PLB3
locus tag: YOL011W
EC number: 3.1.1.5
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10497163]
experiment: EXISTENCE:direct assay:GO:0006660 phosphatidylserine catabolic process [PMID:10497163]
experiment: EXISTENCE:direct assay:GO:0046488 phosphatidylinositol metabolic process [PMID:10497163]
experiment: EXISTENCE:mutant phenotype:GO:0004622 lysophospholipase activity [PMID:10497163]
experiment: EXISTENCE:mutant phenotype:GO:0006660 phosphatidylserine catabolic process [PMID:10497163]
experiment: EXISTENCE:mutant phenotype:GO:0046488 phosphatidylinositol metabolic process [PMID:10497163]
note: Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication
codon start: 1
product: lysophospholipase
translation: MIRPLCSKIIISYIFAISQFLLAANAWSPTDSYVPGTVSCPDDINLVREATSISQNESAWLEKRNKVTSVALKDFLTRATANFSDSSEVLSKLFNDGNSENLPKIAVAVSGGGYRSMLTGAGVLAAMDNRTEGAYEHGLGGLLQSTTYLSGASGGNWLVGTLALNNWTSVQDILNNMQNDDSIWDLSDSIVTPGGINIFKTAKRWDHISNAVESKQNADYNTSLADIWGRALAYNFFPSLNRGGIGLTWSSIRDFPVFQNAEMPFPISVADGRYPGTKVINLNATVFEFNPFEMGSWDPSLNSFANVKYLGTNVSNGVPLERGKCTAGFDNAGFIMGTSSTLFNQFLLRINSTHLPSFITRLARHFLKDLSQDFNDIAVYSPNPFKDTKFLDSDYTTSIVDSDSLFLVDGGEDDENVPVLPLIQKERDVDIIFAVDNSADMRLAWPDGSSLVHTYERQFVKQGQGMSFPYVPDTNTFVNLGLNKKPTFFGCDANNLTDLQYIPPLVVYLPNAEYSFNSNQSAFKLSYSESQRRSMIQNGFEIATRNNFTDDPEFMGCVGCAIIRRKQQALNITLPPECETCFKNYCWNGTLDTTPLPDVEKDVHHSFINVNSFNSSIGQEESLYAGSSASQSSSSSSSSSSSSEIPSATATLEKKAATNSGSHLSGISVKFSAMIMLTLLMFTGAV
SIO_010081: YOL011W
subclass of: SO_0000673
so part of: YOL011W
location: 305349..307409
location: region:305349-307409:1
so has part: feature:305349-307409:1:exon

NP_014632.1
type: Protein
SIO_000068: ncbiprotein

S000005371
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:305349-307409:1:exon

YOL010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCL1
locus tag: YOL010W
so part of: sequence
location: <307938..>309041
location: region:307938-309041:1
so has part: feature:307938-309041:1:exon
subclass of: SO_0000010

854152
type: Gene
SIO_000068: ncbigene

position:307938:1
position: 307938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:309041:1
position: 309041
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307938-309041:1:exon

YOL010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCL1
locus tag: YOL010W
product: rRNA-processing endoribonuclease
transcript id: NM_001183264.1
SIO_010081: YOL010W
subclass of: SO_0000673
so part of: YOL010W
location: <307938..>309041
location: region:307938-309041:1
so has part: feature:307938-309041:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307938-309041:1:exon

YOL010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCL1
locus tag: YOL010W
experiment: EXISTENCE:direct assay:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21849504]
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:21849504]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10790377]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16307926]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:16307926|PMID:12150911]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21849504|PMID:10790377]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10790377]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10790377]
note: Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
codon start: 1
product: rRNA-processing endoribonuclease
translation: MSSSAPKYTTFQGSQNFRLRIVLATLSGKPIKIEKIRSGDLNPGLKDYEVSFLRLIESVTNGSVIEISYTGTTVIYRPGIIVGGASTHICPSSKPVGYFVEPMLYLAPFSKKKFSILFKGITASHNDAGIEAIKWGLMPVMEKFGVRECALHTLKRGSPPLGGGEVHLVVDSLIAQPITMHEIDRPIISSITGVAYSTRVSPSLVNRMIDGAKKVLKNLQCEVNITADVWRGENSGKSPGWGITLVAQSKQKGWSYFAEDIGDAGSIPEELGEKVACQLLEEISKSAAVGRNQLPLAIVYMVIGKEDIGRLRINKEQIDERFIILLRDIKKIFNTEVFLKPVDEADNEDMIATIKGIGFTNTSKKIA
SIO_010081: YOL010W
subclass of: SO_0000673
so part of: YOL010W
location: 307938..309041
location: region:307938-309041:1
so has part: feature:307938-309041:1:exon

NP_014633.1
type: Protein
SIO_000068: ncbiprotein

S000005370
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307938-309041:1:exon

YOL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDM12
locus tag: YOL009C
so part of: sequence
location: complement(<309324..>310139)
location: region:309324-310139:-1
so has part: feature:309324-310139:-1:exon
subclass of: SO_0000010

854153
type: Gene
SIO_000068: ncbigene

position:309324:-1
position: 309324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:310139:-1
position: 310139
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:309324-310139:-1:exon

YOL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDM12
locus tag: YOL009C
product: ERMES complex subunit MDM12
transcript id: NM_001183263.1
SIO_010081: YOL009C
subclass of: SO_0000673
so part of: YOL009C
location: complement(<309324..>310139)
location: region:309324-310139:-1
so has part: feature:309324-310139:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:309324-310139:-1:exon

YOL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDM12
locus tag: YOL009C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:9024686]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0008429 phosphatidylethanolamine binding [PMID:27821511]
experiment: EXISTENCE:direct assay:GO:0031210 phosphatidylcholine binding [PMID:27821511]
experiment: EXISTENCE:direct assay:GO:0120013 lipid transfer activity [PMID:29279306]
experiment: EXISTENCE:direct assay:GO:1901611 phosphatidylglycerol binding [PMID:27821511]
experiment: EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9024686]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:30908556]
experiment: EXISTENCE:mutant phenotype:GO:0015917 aminophospholipid transport [PMID:27469264]
experiment: EXISTENCE:mutant phenotype:GO:0031210 phosphatidylcholine binding [PMID:27821511]
experiment: EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:17410204]
experiment: EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]
experiment: EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:13679517|PMID:17410204]
note: Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase
codon start: 1
product: ERMES complex subunit MDM12
translation: MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEITDPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQFLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFLCDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGELEQFLFTIFKDFLRKELAWPSWINLDFNDGDE
SIO_010081: YOL009C
subclass of: SO_0000673
so part of: YOL009C
location: complement(309324..310139)
location: region:309324-310139:-1
so has part: feature:309324-310139:-1:exon

NP_014634.1
type: Protein
SIO_000068: ncbiprotein

S000005369
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:309324-310139:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1512; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay
so part of: sequence
location: 309359..309925
location: region:309359-309925:1
so has part: feature:309359-309925:1:region

S000130135
type: SGD
SIO_000068: sgd

position:309359:1
position: 309359
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:309925:1
position: 309925
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:309359-309925:1:region

YOL008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COQ10
locus tag: YOL008W
so part of: sequence
location: <310312..>310935
location: region:310312-310935:1
so has part: feature:310312-310935:1:exon
subclass of: SO_0000010

854154
type: Gene
SIO_000068: ncbigene

position:310312:1
position: 310312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:310935:1
position: 310935
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310312-310935:1:exon

YOL008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COQ10
locus tag: YOL008W
product: ubiquinone-binding protein COQ10
transcript id: NM_001183262.1
SIO_010081: YOL008W
subclass of: SO_0000673
so part of: YOL008W
location: <310312..>310935
location: region:310312-310935:1
so has part: feature:310312-310935:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310312-310935:1:exon

YOL008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COQ10
locus tag: YOL008W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16230336]
experiment: EXISTENCE:direct assay:GO:0048039 ubiquinone binding [PMID:16230336]
experiment: EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:23270816]
experiment: EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:23270816|PMID:50596]
note: Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A
codon start: 1
product: ubiquinone-binding protein COQ10
translation: MVLIIRPSQTLILFRKAMLKPIGRYPLKRNFFGLSGTNHTIREQRYVLRKAINAPPSTVYAAVSEVAQYKEFIPYCVDSFVDKRNPVDNKPLIAGLRVGFKQYDEEFICNVTCKDTDHTYTVVAETISHNLFHLLISKWTIMPHPNRPNAAMVELLLRFKFKSRIYNSVSLIFAKTVTELVMNAFAKRAYHLVRLAMLKPSSKEGSP
SIO_010081: YOL008W
subclass of: SO_0000673
so part of: YOL008W
location: 310312..310935
location: region:310312-310935:1
so has part: feature:310312-310935:1:exon

NP_014635.1
type: Protein
SIO_000068: ncbiprotein

S000005368
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310312-310935:1:exon

YOL007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSI2
locus tag: YOL007C
so part of: sequence
location: complement(<311342..>312367)
location: region:311342-312367:-1
so has part: feature:311342-312367:-1:exon
subclass of: SO_0000010

854155
type: Gene
SIO_000068: ncbigene

position:311342:-1
position: 311342
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:312367:-1
position: 312367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:311342-312367:-1:exon

YOL007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSI2
locus tag: YOL007C
product: Csi2p
transcript id: NM_001183261.1
SIO_010081: YOL007C
subclass of: SO_0000673
so part of: YOL007C
location: complement(<311342..>312367)
location: region:311342-312367:-1
so has part: feature:311342-312367:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:311342-312367:-1:exon

YOL007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSI2
locus tag: YOL007C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15282802|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]
note: hypothetical protein; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
codon start: 1
product: Csi2p
translation: MRLPEISIWKVILLLHLFALQEFQLVSAANLPSLSSSTKAADSSSKGSSSAKTTTSLGKSSVTSKDVSSSHNVTSSTKMPKITTSASTSLYTNSSLWSNNSVISTSSITPSSVYIPVTDGNKFLYQAHHPNGTVFIAFAGCLGAILLSLTGAWIALNIKSWRSARKENKLRNLENQYQHDPFYFQTNINDDESETSSHSDDSDISEKVLKNNSSRMSLYTLGSTSVLNLLNNKTDANDNFRSSMFISPTEILQSDANNSNTWSQSNESAIYDSLSSTPREPGATQILGKFTDSTNPFNYTSYNLSPDSEDRSTPKSNVSQGKVKKYRPPSVHLDQLLDGKE
SIO_010081: YOL007C
subclass of: SO_0000673
so part of: YOL007C
location: complement(311342..312367)
location: region:311342-312367:-1
so has part: feature:311342-312367:-1:exon

NP_014636.1
type: Protein
SIO_000068: ncbiprotein

S000005367
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:311342-312367:-1:exon

YOL006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAK1
alternative label: MAK17
gene: TOP1
locus tag: YOL006C
gene synonym: MAK1; MAK17
so part of: sequence
location: complement(<313078..>315387)
location: region:313078-315387:-1
so has part: feature:313078-315387:-1:exon
subclass of: SO_0000010

854156
type: Gene
SIO_000068: ncbigene

position:313078:-1
position: 313078
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315387:-1
position: 315387
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:313078-315387:-1:exon

YOL006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAK1
alternative label: MAK17
gene: TOP1
locus tag: YOL006C
gene synonym: MAK1; MAK17
product: DNA topoisomerase 1
transcript id: NM_001183260.1
SIO_010081: YOL006C
subclass of: SO_0000673
so part of: YOL006C
location: complement(<313078..>315387)
location: region:313078-315387:-1
so has part: feature:313078-315387:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:313078-315387:-1:exon

YOL006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAK1
alternative label: MAK17
gene: TOP1
locus tag: YOL006C
gene synonym: MAK1; MAK17
EC number: 5.6.2.1
experiment: EXISTENCE:direct assay:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:6088500|PMID:6319395]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6088500]
experiment: EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:6088500]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:genetic interaction:GO:0009303 rRNA transcription [PMID:2436053]
experiment: EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:2902925]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10082585]
experiment: EXISTENCE:mutant phenotype:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:2989818|PMID:6319395]
experiment: EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:2989818]
experiment: EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:2549254]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9199287]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:1660829]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:2840207]
experiment: EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:8895658]
experiment: EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:8895658]
experiment: EXISTENCE:physical interaction:GO:0005730 nucleolus [PMID:10967121]
note: Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation
codon start: 1
product: DNA topoisomerase 1
translation: MTIADASKVNHELSSDDDDDVPLSQTLKKRKVASMNSASLQDEAEPYDSDEAISKISKKKTKKIKTEPVQSSSLPSPPAKKSATSKPKKIKKEDGDVKVKTTKKEEQENEKKKREEEEEEDKKAKEEEEEYKWWEKENEDDTIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLNGIEIKEFSRCDFTKMFDYFQLQKEQKKQLTSQEKKQIRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAPVPPAPEGHKWGEIRHDNTVQWLAMWRENIFNSFKYVRLAANSSLKGQSDYKKFEKARQLKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDVFALRAGGEKSEDEADTVGCCSLRYEHVTLKPPNTVIFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRPPKQPGHQLFDRLDPSILNKYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPNKGSVAEKILKYNAANRTVAILCNHQRTVTKGHAQTVEKANNRIQELEWQKIRCKRAILQLDKDLLKKEPKYFEEIDDLTKEDEATIHKRIIDREIEKYQRKFVRENDKRKFEKEELLPESQLKEWLEKVDEKKQEFEKELKTGEVELKSSWNSVEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLGTSKINYIDPRLSVVFCKKYDVPIEKIFTKTLREKFKWAIESVDENWRF
SIO_010081: YOL006C
subclass of: SO_0000673
so part of: YOL006C
location: complement(313078..315387)
location: region:313078-315387:-1
so has part: feature:313078-315387:-1:exon

NP_014637.1
type: Protein
SIO_000068: ncbiprotein

S000005366
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:313078-315387:-1:exon

YOL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPB11
locus tag: YOL005C
so part of: sequence
location: complement(<315813..>316175)
location: region:315813-316175:-1
so has part: feature:315813-316175:-1:exon
subclass of: SO_0000010

854157
type: Gene
SIO_000068: ncbigene

position:315813:-1
position: 315813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316175:-1
position: 316175
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:315813-316175:-1:exon

YOL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPB11
locus tag: YOL005C
product: DNA-directed RNA polymerase II core subunit RPB11
transcript id: NM_001183259.1
SIO_010081: YOL005C
subclass of: SO_0000673
so part of: YOL005C
location: complement(<315813..>316175)
location: region:315813-316175:-1
so has part: feature:315813-316175:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:315813-316175:-1:exon

YOL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPB11
locus tag: YOL005C
experiment: EXISTENCE:direct assay:GO:0001055 RNA polymerase II activity [PMID:8288647]
experiment: EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]
experiment: EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:17179178]
experiment: EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:16537912]
note: RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
codon start: 1
product: DNA-directed RNA polymerase II core subunit RPB11
translation: MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDRKVLFAAYKVEHPFFARFKLRIQTTEGYDPKDALKNACNSIINKLGALKTNFETEWNLQTLAADDAF
SIO_010081: YOL005C
subclass of: SO_0000673
so part of: YOL005C
location: complement(315813..316175)
location: region:315813-316175:-1
so has part: feature:315813-316175:-1:exon

NP_014638.1
type: Protein
SIO_000068: ncbiprotein

S000005365
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:315813-316175:-1:exon

YOL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPE1
alternative label: GAM2
alternative label: RPD1
alternative label: SDI1
alternative label: SDS16
alternative label: UME4
gene: SIN3
locus tag: YOL004W
gene synonym: CPE1; GAM2; RPD1; SDI1; SDS16; UME4
so part of: sequence
location: <316938..>321548
location: region:316938-321548:1
so has part: feature:316938-321548:1:exon
subclass of: SO_0000010

854158
type: Gene
SIO_000068: ncbigene

position:316938:1
position: 316938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321548:1
position: 321548
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316938-321548:1:exon

YOL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPE1
alternative label: GAM2
alternative label: RPD1
alternative label: SDI1
alternative label: SDS16
alternative label: UME4
gene: SIN3
locus tag: YOL004W
gene synonym: CPE1; GAM2; RPD1; SDI1; SDS16; UME4
product: transcriptional regulator SIN3
transcript id: NM_001183258.1
SIO_010081: YOL004W
subclass of: SO_0000673
so part of: YOL004W
location: <316938..>321548
location: region:316938-321548:1
so has part: feature:316938-321548:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316938-321548:1:exon

YOL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPE1
alternative label: GAM2
alternative label: RPD1
alternative label: SDI1
alternative label: SDS16
alternative label: UME4
gene: SIN3
locus tag: YOL004W
gene synonym: CPE1; GAM2; RPD1; SDI1; SDS16; UME4
experiment: EXISTENCE:direct assay:GO:0032221 Rpd3S/Clr6-CII complex [PMID:16286007|PMID:16286008]
experiment: EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16286008|PMID:16314178|PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9234741]
experiment: EXISTENCE:genetic interaction:GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle [PMID:17908798]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11095743|PMID:2690066]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:14737171]
experiment: EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9150136]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:14711989]
experiment: EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:15143171]
experiment: EXISTENCE:mutant phenotype:GO:0044804 autophagy of nucleus [PMID:31553911]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11095743|PMID:14737171|PMID:20398213]
experiment: EXISTENCE:mutant phenotype:GO:0051038 negative regulation of transcription involved in meiotic cell cycle [PMID:17158929]
experiment: EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10388812]
experiment: EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10082585|PMID:10388812]
experiment: EXISTENCE:mutant phenotype:GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress [PMID:20398213]
experiment: EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:31553911]
experiment: EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9150136]
note: Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
codon start: 1
product: transcriptional regulator SIN3
translation: MSQVWHNSNSQSNDVATSNDATGSNERNEKEPSLQGNKPGFVQQQQRITLPSLSALSTKEEDRRDSNGQQALTSHAAHILGYPPPHSNAMPSIATDSALKQPHEYHPRPKSSSSSPSINASLMNAGPAPLPTVGAASFSLSRFDNPLPIKAPVHTEEPKSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHDEDADYRPLNVKDALSYLEQVKFQFSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSSNPDDPIRVTTPMGTTTVNNNISPSGRGTTDAQELGSFPESDGNGVQQPSNVPMVPSSVYQSEQNQDQQQSLPLLATSSGLPSIQQPEMPAHRQIPQSQSLVPQEDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLPDSSASANQQVQHAQQHAQQQHEAQMHAQAQAQAQAQAQVEQQKQQQQFLYPASGYYGHPSNRGIPQQNLPPIGSFSPPTNGSTVHEAYQDQQHMQPPHFMPLPSIVQHGPNMVHQGIANENPPLSDLRTSLTEQYAPSSIQHQQQHPQSISPIANTQYGDIPVRPEIDLDPSIVPVVPEPTEPIENNISLNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSNKELFTWFKNFVGYQEKTKCIENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEISSIKVDQTNKKIHWLTPKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEESLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDILHRSRYQKLKRSNDEDGKVPQLSEPPEEEPNTIEEEELIDEEAKNPWLTGNLVEEANSQGIIQNRSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQDIDGTEVDEEFSPEGISVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQKGMVSQKKELISKFLDCAVGLRNNLDEAQKLSMQKKWENLKDSIAKTSAGNQGIESETEKGKITKQEQSDNLDSSTASVLPASITTVPQDDNIETTGNTESSDKGAKIQ
SIO_010081: YOL004W
subclass of: SO_0000673
so part of: YOL004W
location: 316938..321548
location: region:316938-321548:1
so has part: feature:316938-321548:1:exon

NP_014639.1
type: Protein
SIO_000068: ncbiprotein

S000005364
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316938-321548:1:exon

YOL003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PFA4
locus tag: YOL003C
so part of: sequence
location: complement(<321858..>322994)
location: region:321858-322994:-1
so has part: feature:321858-322994:-1:exon
subclass of: SO_0000010

854159
type: Gene
SIO_000068: ncbigene

position:321858:-1
position: 321858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:322994:-1
position: 322994
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321858-322994:-1:exon

YOL003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PFA4
locus tag: YOL003C
product: palmitoyltransferase PFA4
transcript id: NM_001183257.1
SIO_010081: YOL003C
subclass of: SO_0000673
so part of: YOL003C
location: complement(<321858..>322994)
location: region:321858-322994:-1
so has part: feature:321858-322994:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:321858-322994:-1:exon

YOL003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PFA4
locus tag: YOL003C
EC number: 2.3.1.225
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16647879|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:16818716|PMID:26224664]
experiment: EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16751107|PMID:16818716]
note: Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
codon start: 1
product: palmitoyltransferase PFA4
translation: MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICTNPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANYPHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLTITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKDAEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKYEANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKWYNDWGESLDDFGVDVDME
SIO_010081: YOL003C
subclass of: SO_0000673
so part of: YOL003C
location: complement(321858..322994)
location: region:321858-322994:-1
so has part: feature:321858-322994:-1:exon

NP_014640.1
type: Protein
SIO_000068: ncbiprotein

S000005363
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:321858-322994:-1:exon

YOL002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PHO36
gene: IZH2
locus tag: YOL002C
gene synonym: PHO36
so part of: sequence
location: complement(<323411..>324364)
location: region:323411-324364:-1
so has part: feature:323411-324364:-1:exon
subclass of: SO_0000010

854160
type: Gene
SIO_000068: ncbigene

position:323411:-1
position: 323411
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:324364:-1
position: 324364
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323411-324364:-1:exon

YOL002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PHO36
gene: IZH2
locus tag: YOL002C
gene synonym: PHO36
product: PAQR-type receptor
transcript id: NM_001183256.1
SIO_010081: YOL002C
subclass of: SO_0000673
so part of: YOL002C
location: complement(<323411..>324364)
location: region:323411-324364:-1
so has part: feature:323411-324364:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323411-324364:-1:exon

YOL002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PHO36
gene: IZH2
locus tag: YOL002C
gene synonym: PHO36
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18625204]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15664187]
experiment: EXISTENCE:mutant phenotype:GO:0006882 cellular zinc ion homeostasis [PMID:15060275]
experiment: EXISTENCE:mutant phenotype:GO:0009636 response to toxic substance [PMID:15664187]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15664187]
note: Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor
codon start: 1
product: PAQR-type receptor
translation: MSTLLERTKSVQELKKRAAGKTSANPAEVAKAKKVLRRLYSWDEIPEWQRDNDFILHGYVKETSSFIETFKSLFYLHNESVNIYSHLIPALGFFTVLLLDKSTIKVFATTTWLDHMVIDLFYSGAFACLILSSSFHCLKSHSLRIATLGNKLDYLGICILIVTSMVSILYYGYFEKFSLFCLFALITVSFGIACSIVSLKDKFRKREWRPYRAGLFVCFGLSSIIPIFSGLYCYSFSEIWTQIQLFWVLLGGVLYIIGAVLYGMRFPEKICPGKFDIWGHSHQLFHFLVVIAALCHLRGLLNSYELVHIKMENGIVS
SIO_010081: YOL002C
subclass of: SO_0000673
so part of: YOL002C
location: complement(323411..324364)
location: region:323411-324364:-1
so has part: feature:323411-324364:-1:exon

NP_014641.2
type: Protein
SIO_000068: ncbiprotein

S000005362
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323411-324364:-1:exon

YOL001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AGS3
alternative label: TUP7
alternative label: VAC5
gene: PHO80
locus tag: YOL001W
gene synonym: AGS3; TUP7; VAC5
so part of: sequence
location: <325249..>326130
location: region:325249-326130:1
so has part: feature:325249-326130:1:exon
subclass of: SO_0000010

854161
type: Gene
SIO_000068: ncbigene

position:325249:1
position: 325249
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326130:1
position: 326130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325249-326130:1:exon

YOL001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AGS3
alternative label: TUP7
alternative label: VAC5
gene: PHO80
locus tag: YOL001W
gene synonym: AGS3; TUP7; VAC5
product: Pho80p
transcript id: NM_001183255.1
SIO_010081: YOL001W
subclass of: SO_0000673
so part of: YOL001W
location: <325249..>326130
location: region:325249-326130:1
so has part: feature:325249-326130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325249-326130:1:exon

YOL001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AGS3
alternative label: TUP7
alternative label: VAC5
gene: PHO80
locus tag: YOL001W
gene synonym: AGS3; TUP7; VAC5
experiment: EXISTENCE:direct assay:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:8108735]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9853758]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8108735]
experiment: EXISTENCE:direct assay:GO:1990860 Pho85-Pho80 CDK-cyclin complex [PMID:8108735]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:3915785]
experiment: EXISTENCE:genetic interaction:GO:0045936 negative regulation of phosphate metabolic process [PMID:3915785]
experiment: EXISTENCE:genetic interaction:GO:0050849 negative regulation of calcium-mediated signaling [PMID:16455487]
experiment: EXISTENCE:mutant phenotype:GO:0006875 cellular metal ion homeostasis [PMID:20429018]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:16455487]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:27252384]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:8108735]
note: Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
codon start: 1
product: Pho80p
translation: MESTSGERSENIHEDQGIPKVILPADFNKCSRTDLVVLISRMLVSLIAINENSATKKSDDQITLTRYHSKIPPNISIFNYFIRLTKFSSLEHCVLMTSLYYIDLLQTVYPDFTLNSLTAHRFLLTATTVATKGLCDSFSTNAHYAKVGGVRCHELNILENDFLKRVNYRIIPRDHNITLCSIEQKQKKFVIDKNALGSLDLDSYSYVNRPKSGYNVLDKYYRRIVQLVGSFNASPDKSRKVDYVLPPNIDIVSESGSQTTQLKGSSSPNSHSSQKRYSEAKDAHIYNKRSKPD
SIO_010081: YOL001W
subclass of: SO_0000673
so part of: YOL001W
location: 325249..326130
location: region:325249-326130:1
so has part: feature:325249-326130:1:exon

NP_014642.1
type: Protein
SIO_000068: ncbiprotein

S000005361
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325249-326130:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN15; Chromosome XV centromere
so part of: sequence
location: complement(326584..326702)
location: region:326584-326702:-1
so has part: feature:326584-326702:-1:region

S000006476
type: SGD
SIO_000068: sgd

position:326584:-1
position: 326584
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:326702:-1
position: 326702
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326584-326702:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN15_CDEIII of CEN15
so part of: sequence
location: complement(326584..326608)
location: region:326584-326608:-1
so has part: feature:326584-326608:-1:region

position:326608:-1
position: 326608
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326584-326608:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN15_CDEII of CEN15
so part of: sequence
location: complement(326609..326692)
location: region:326609-326692:-1
so has part: feature:326609-326692:-1:region

position:326609:-1
position: 326609
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:326692:-1
position: 326692
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326609-326692:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN15_CDEI of CEN15
so part of: sequence
location: complement(326693..326702)
location: region:326693-326702:-1
so has part: feature:326693-326702:-1:region

position:326693:-1
position: 326693
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326693-326702:-1:region

YOR001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP6
locus tag: YOR001W
so part of: sequence
location: <326832..>329033
location: region:326832-329033:1
so has part: feature:326832-329033:1:exon
subclass of: SO_0000010

854162
type: Gene
SIO_000068: ncbigene

position:326832:1
position: 326832
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:329033:1
position: 329033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326832-329033:1:exon

YOR001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP6
locus tag: YOR001W
product: exosome nuclease subunit RRP6
transcript id: NM_001183420.1
SIO_010081: YOR001W
subclass of: SO_0000673
so part of: YOR001W
location: <326832..>329033
location: region:326832-329033:1
so has part: feature:326832-329033:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326832-329033:1:exon

YOR001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP6
locus tag: YOR001W
experiment: EXISTENCE:direct assay:GO:0000175 3'-5'-exoribonuclease activity [PMID:10611239]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10611239|PMID:23580640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108|PMID:31662437]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:31662437]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860]
experiment: EXISTENCE:genetic interaction:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]
experiment: EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172|PMID:10716935]
experiment: EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:12417728|PMID:17410208|PMID:11586364]
experiment: EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16541108]
experiment: EXISTENCE:genetic interaction:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:18456844]
experiment: EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172|PMID:18940861|PMID:9582370]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18614049]
experiment: EXISTENCE:mutant phenotype:GO:0032204 regulation of telomere maintenance [PMID:28160602]
experiment: EXISTENCE:mutant phenotype:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172|PMID:10611222|PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:27124216]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791|PMID:15572680|PMID:16431988|PMID:18007593|P MID:18940861|PMID:15173578]
experiment: EXISTENCE:mutant phenotype:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:16431988]
experiment: EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759|PMID:16973436|PMID:18007593]
experiment: EXISTENCE:mutant phenotype:GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process [PMID:18022365]
experiment: EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491|PMID:19369424]
experiment: EXISTENCE:mutant phenotype:GO:0071044 histone mRNA catabolic process [PMID:17179095]
experiment: EXISTENCE:mutant phenotype:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10611222|PMID:16373491|PMID:18951092]
note: Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based
codon start: 1
product: exosome nuclease subunit RRP6
translation: MTSENPDVLLSRVINVVRAASSLASQDVDFYKNLDRGFSKDLKSKADKLADMANEIILSIDEHHESFELKEEDISDLWNNFGNIMDNLLEMSDHSLDKLNCAINSKSRGSDLQYLGEFSGKNFSPTKRVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDENNPSHYPHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLEDLKNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNEVFTNPSIVKVFHGAFMDIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLAYLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLRNKLIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTPTDVIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNTNEEATPIPSSETKADGILLETISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKDGLPNKVKTEDIRIRAQNFKSALANLEDIIFEIEKPLVVPVKLEEIKTVDPASAPNHSPEIDNLDDLVVLKKKNIQKKQPAKEKGVTEKDAVDYSKIPNILSNKPGQNNRQQKKRRFDPSSSDSNGPRAAKKRRPAAKGKNLSFKR
SIO_010081: YOR001W
subclass of: SO_0000673
so part of: YOR001W
location: 326832..329033
location: region:326832-329033:1
so has part: feature:326832-329033:1:exon

NP_014643.1
type: Protein
SIO_000068: ncbiprotein

S000005527
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326832-329033:1:exon

YOR002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALG6
locus tag: YOR002W
so part of: sequence
location: <329417..>331051
location: region:329417-331051:1
so has part: feature:329417-331051:1:exon
subclass of: SO_0000010

854163
type: Gene
SIO_000068: ncbigene

position:329417:1
position: 329417
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:331051:1
position: 331051
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:329417-331051:1:exon

YOR002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALG6
locus tag: YOR002W
product: dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
transcript id: NM_001183421.1
SIO_010081: YOR002W
subclass of: SO_0000673
so part of: YOR002W
location: <329417..>331051
location: region:329417-331051:1
so has part: feature:329417-331051:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:329417-331051:1:exon

YOR002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALG6
locus tag: YOR002W
EC number: 2.4.1.267
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8877369]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8877369]
experiment: EXISTENCE:mutant phenotype:GO:0006490 oligosaccharide-lipid intermediate biosynthetic process [PMID:10336995]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:15794922]
experiment: EXISTENCE:mutant phenotype:GO:0016758 hexosyltransferase activity [PMID:8877369]
experiment: EXISTENCE:mutant phenotype:GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [PMID:10336995]
note: ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant
codon start: 1
product: dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
translation: MAIGKRLLVNKPAEESFYASPMYDFLYPFRPVGNQWLPEYIIFVCAVILRCTIGLGPYSGKGSPPLYGDFEAQRHWMEITQHLPLSKWYWYDLQYWGLDYPPLTAFHSYLLGLIGSFFNPSWFALEKSRGFESPDNGLKTYMRSTVIISDILFYFPAVIYFTKWLGRYRNQSPIGQSIAASAILFQPSLMLIDHGHFQYNSVMLGLTAYAINNLLDEYYAMAAVCFVLSICFKQMALYYAPIFFAYLLSRSLLFPKFNIARLTVIAFATLATFAIIFAPLYFLGGGLKNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKERFTIQQLQLYSLIATVIGFLPAMIMTLLHPKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYSSTDWNVLSLVSWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIGNFSFITPRFLPKSLTPGPSISSINSDYRRRSLLPYNVVWKSFIIGTYIAMGFYHFLDQFVAPPSKYPDLWVLLNCAVGFICFSIFWLWSYYKIFTSGSKSMKDL
SIO_010081: YOR002W
subclass of: SO_0000673
so part of: YOR002W
location: 329417..331051
location: region:329417-331051:1
so has part: feature:329417-331051:1:exon

NP_014644.1
type: Protein
SIO_000068: ncbiprotein

S000005528
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:329417-331051:1:exon

YOR003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YSP3
locus tag: YOR003W
so part of: sequence
location: <331455..>332891
location: region:331455-332891:1
so has part: feature:331455-332891:1:exon
subclass of: SO_0000010

854164
type: Gene
SIO_000068: ncbigene

position:331455:1
position: 331455
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332891:1
position: 332891
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:331455-332891:1:exon

YOR003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YSP3
locus tag: YOR003W
product: putative subtilisin-like protease YSP3
transcript id: NM_001183422.1
SIO_010081: YOR003W
subclass of: SO_0000673
so part of: YOR003W
location: <331455..>332891
location: region:331455-332891:1
so has part: feature:331455-332891:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:331455-332891:1:exon

YOR003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YSP3
locus tag: YOR003W
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:17651441]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication
codon start: 1
product: putative subtilisin-like protease YSP3
translation: MKFSTILPILWANCCLCMIIPDFDGIVRFIENIDGTRSVRAGEGLGQHDPGNFHTEHQHVAHKTEFLPYRYVIVFNEDISLQQIQSHMQVVQKDHSTSVGKLTENDAFWRVISSSVSSKSQFGGIDNFFDINGLFRGYTGYFTDEIIKIISQDPIIKFVEQETTVKISNSSLQEEAPWGLHRVSHREKPKYGQDLEYLYEDAAGKGVTSYVLDTGIDTEHEDFEGRAEWGAVIPANDEASDLNGHGTHCAGIIGSKHFGVAKNTKIVAVKVLRSNGEGTVSDVIKGIEYVTKEHIESSKKKNKEFKGSTANLSLGSSKSLAMEMAVNAAVDSGVHFAIAAGNEDEDACLSSPAGAEKSITVGASTFSDDRAFFSNWGTCVDVFAPGINIMSTYIGSRNATLSLSGTSMASPHVAGILSYFLSLQPAPDSEFFNDAPSPQELKEKVLKFSTQGVLGDIGDDTPNKLIYNGGGKKLDGFW
SIO_010081: YOR003W
subclass of: SO_0000673
so part of: YOR003W
location: 331455..332891
location: region:331455-332891:1
so has part: feature:331455-332891:1:exon

NP_014645.1
type: Protein
SIO_000068: ncbiprotein

S000005529
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:331455-332891:1:exon

YOR004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP23
locus tag: YOR004W
so part of: sequence
location: <333592..>334356
location: region:333592-334356:1
so has part: feature:333592-334356:1:exon
subclass of: SO_0000010

854165
type: Gene
SIO_000068: ncbigene

position:333592:1
position: 333592
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334356:1
position: 334356
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:333592-334356:1:exon

YOR004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP23
locus tag: YOR004W
product: rRNA-binding ribosome biosynthesis protein UTP23
transcript id: NM_001183423.1
SIO_010081: YOR004W
subclass of: SO_0000673
so part of: YOR004W
location: <333592..>334356
location: region:333592-334356:1
so has part: feature:333592-334356:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:333592-334356:1:exon

YOR004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP23
locus tag: YOR004W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16769905|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:16769905]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:24152547]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]
experiment: EXISTENCE:mutant phenotype:GO:0070181 small ribosomal subunit rRNA binding [PMID:24152547]
experiment: EXISTENCE:physical interaction:GO:0032040 small-subunit processome [PMID:16769905]
note: Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
codon start: 1
product: rRNA-binding ribosome biosynthesis protein UTP23
translation: MRQKRAKSYRKQLLVYSHTFKFREPYQVLVDNQLVLECNNSNFNLPSGLKRTLQADVKVMITQCCIQALYETRNDGAINLAKQFERRRCNHSFKDPKSPAECIESVVNISGANKHRYVVASQDIDLRRKLRTVPGVPLIHLTRSVMVMEPLSTASAKASKITEEQKLYKGLNDPNIEKLQESGDGSGKESITKKRKLGPKAPNPLSVKKKKKVNSPSDEVKDKEDTSKEKKKRRRRKHKSNTNVPVSNGTTAAQ
SIO_010081: YOR004W
subclass of: SO_0000673
so part of: YOR004W
location: 333592..334356
location: region:333592-334356:1
so has part: feature:333592-334356:1:exon

NP_014646.1
type: Protein
SIO_000068: ncbiprotein

S000005530
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:333592-334356:1:exon

YOR005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LIG4
gene: DNL4
locus tag: YOR005C
gene synonym: LIG4
so part of: sequence
location: complement(<334509..>337343)
location: region:334509-337343:-1
so has part: feature:334509-337343:-1:exon
subclass of: SO_0000010

854166
type: Gene
SIO_000068: ncbigene

position:334509:-1
position: 334509
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337343:-1
position: 337343
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334509-337343:-1:exon

YOR005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LIG4
gene: DNL4
locus tag: YOR005C
gene synonym: LIG4
product: DNA ligase (ATP) DNL4
transcript id: NM_001183424.1
SIO_010081: YOR005C
subclass of: SO_0000673
so part of: YOR005C
location: complement(<334509..>337343)
location: region:334509-337343:-1
so has part: feature:334509-337343:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334509-337343:-1:exon

YOR005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LIG4
gene: DNL4
locus tag: YOR005C
gene synonym: LIG4
EC number: 6.5.1.1
experiment: EXISTENCE:direct assay:GO:0003910 DNA ligase (ATP) activity [PMID:9242411|PMID:9271115]
experiment: EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]
experiment: EXISTENCE:mutant phenotype:GO:0003910 DNA ligase (ATP) activity [PMID:9271115]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9242411]
experiment: EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:20541983]
experiment: EXISTENCE:physical interaction:GO:0032807 DNA ligase IV complex [PMID:17567543]
note: DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome
codon start: 1
product: DNA ligase (ATP) DNL4
translation: MISALDSIPEPQNFAPSPDFKWLCEELFVKIHEVQINGTAGTGKSRSFKYYEIISNFVEMWRKTVGNNIYPALVLALPYRDRRIYNIKDYVLIRTICSYLKLPKNSATEQRLKDWKQRVGKGGNLSSLLVEEIAKRRAEPSSKAITIDNVNHYLDSLSGDRFASGRGFKSLVKSKPFLHCVENMSFVELKYFFDIVLKNRVIGGQEHKLLNCWHPDAQDYLSVISDLKVVTSKLYDPKVRLKDDDLSIKVGFAFAPQLAKKVNLSYEKICRTLHDDFLVEEKMDGERIQVHYMNYGESIKFFSRRGIDYTYLYGASLSSGTISQHLRFTDSVKECVLDGEMVTFDAKRRVILPFGLVKGSAKEALSFNSINNVDFHPLYMVFDLLYLNGTSLTPLPLHQRKQYLNSILSPLKNIVEIVRSSRCYGVESIKKSLEVAISLGSEGVVLKYYNSSYNVASRNNNWIKVKPEYLEEFGENLDLIVIGRDSGKKDSFMLGLLVLDEEEYKKHQGDSSEIVDHSSQEKHIQNSRRRVKKILSFCSIANGISQEEFKEIDRKTRGHWKRTSEVAPPASILEFGSKIPAEWIDPSESIVLEIKSRSLDNTETNMQKYATNCTLYGGYCKRIRYDKEWTDCYTLNDLYESRTVKSNPSYQAERSQLGLIRKKRKRVLISDSFHQNRKQLPISNIFAGLLFYVLSDYVTEDTGIRITRAELEKTIVEHGGKLIYNVILKRHSIGDVRLISCKTTTECKALIDRGYDILHPNWVLDCIAYKRLILIEPNYCFNVSQKMRAVAEKRVDCLGDSFENDISETKLSSLYKSQLSLPPMGELEIDSEVRRFPLFLFSNRIAYVPRRKISTEDDIIEMKIKLFGGKITDQQSLCNLIIIPYTDPILRKDCMNEVHEKIKEQIKASDTIPKIARVVAPEWVDHSINENCQVPEEDFPVVNY
SIO_010081: YOR005C
subclass of: SO_0000673
so part of: YOR005C
location: complement(334509..337343)
location: region:334509-337343:-1
so has part: feature:334509-337343:-1:exon

NP_014647.1
type: Protein
SIO_000068: ncbiprotein

S000005531
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334509-337343:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1513; Autonomously Replicating Sequence
so part of: sequence
location: 337424..337491
location: region:337424-337491:1
so has part: feature:337424-337491:1:region

S000118489
type: SGD
SIO_000068: sgd

position:337424:1
position: 337424
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:337491:1
position: 337491
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337424-337491:1:region

YOR006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TSR3
locus tag: YOR006C
so part of: sequence
location: complement(<337680..>338621)
location: region:337680-338621:-1
so has part: feature:337680-338621:-1:exon
subclass of: SO_0000010

854167
type: Gene
SIO_000068: ncbigene

position:337680:-1
position: 337680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:338621:-1
position: 338621
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337680-338621:-1:exon

YOR006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TSR3
locus tag: YOR006C
product: ribosome biogenesis protein TSR3
transcript id: NM_001183425.1
SIO_010081: YOR006C
subclass of: SO_0000673
so part of: YOR006C
location: complement(<337680..>338621)
location: region:337680-338621:-1
so has part: feature:337680-338621:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337680-338621:-1:exon

YOR006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TSR3
locus tag: YOR006C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27084949|PMID:14562095|PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]
experiment: EXISTENCE:mutant phenotype:GO:0106388 18S rRNA aminocarboxypropyltransferase activity [PMID:27084949]
note: Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes
codon start: 1
product: ribosome biogenesis protein TSR3
translation: MGKGKNKMHEPKNGRPQRGANGHSSRQNHRRMEMKYDNSEKMKFPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGASVVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELLSHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRRGNGSQSDTSESEENSEQSDLEGNNQCIEYDSLGNAIRIDNMKSREAQSEESEDEESGSKENGEPLSYDPLGNLIR
SIO_010081: YOR006C
subclass of: SO_0000673
so part of: YOR006C
location: complement(337680..338621)
location: region:337680-338621:-1
so has part: feature:337680-338621:-1:exon

NP_014648.1
type: Protein
SIO_000068: ncbiprotein

S000005532
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337680-338621:-1:exon

YOR007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SGT2
locus tag: YOR007C
so part of: sequence
location: complement(<338938..>339978)
location: region:338938-339978:-1
so has part: feature:338938-339978:-1:exon
subclass of: SO_0000010

854168
type: Gene
SIO_000068: ncbigene

position:338938:-1
position: 338938
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339978:-1
position: 339978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:338938-339978:-1:exon

YOR007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SGT2
locus tag: YOR007C
product: Sgt2p
transcript id: NM_001183426.1
SIO_010081: YOR007C
subclass of: SO_0000673
so part of: YOR007C
location: complement(<338938..>339978)
location: region:338938-339978:-1
so has part: feature:338938-339978:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:338938-339978:-1:exon

YOR007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SGT2
locus tag: YOR007C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]
experiment: EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:12482202]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:20850366]
note: Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: Sgt2p
translation: MSASKEEIAALIVNYFSSIVEKKEISEDGADSLNVAMDCISEAFGFEREAVSGILGKSEFKGQHLADILNSASRVPESNKKDDAENVEINIPEDDAETKAKAEDLKMQGNKAMANKDYELAINKYTEAIKVLPTNAIYYANRAAAHSSLKEYDQAVKDAESAISIDPSYFRGYSRLGFAKYAQGKPEEALEAYKKVLDIEGDNATEAMKRDYESAKKKVEQSLNLEKTVPEQSRDADVDASQGASAGGLPDLGSLLGGGLGGLMNNPQLMQAAQKMMSNPGAMQNIQKMMQDPSIRQMAEGFASGGGTPNLSDLMNNPALRNMAGNLFGGAGAQSTDETPDNENKQ
SIO_010081: YOR007C
subclass of: SO_0000673
so part of: YOR007C
location: complement(338938..339978)
location: region:338938-339978:-1
so has part: feature:338938-339978:-1:exon

NP_014649.1
type: Protein
SIO_000068: ncbiprotein

S000005533
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:338938-339978:-1:exon

YNCO0012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0012C
so part of: sequence
location: complement(340299..340371)
location: region:340299-340371:-1
so has part: feature:340299-340371:-1:exon
subclass of: SO_0000663

854169
type: Gene
SIO_000068: ncbigene

position:340299:-1
position: 340299
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:340371:-1
position: 340371
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:340299-340371:-1:exon

YNCO0012C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0012C
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCO0012C
subclass of: SO_0000673
so part of: YNCO0012C
location: complement(340299..340371)
location: region:340299-340371:-1
so has part: feature:340299-340371:-1:exon

S000006705
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:340299-340371:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(340598..340898)
location: region:340598-340898:-1
so has part: feature:340598-340898:-1:region

S000007153
type: SGD
SIO_000068: sgd

position:340598:-1
position: 340598
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:340898:-1
position: 340898
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:340598-340898:-1:region

YOR008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HCS77
alternative label: WSC1
gene: SLG1
locus tag: YOR008C
gene synonym: HCS77; WSC1
so part of: sequence
location: complement(<341278..>342414)
location: region:341278-342414:-1
so has part: feature:341278-342414:-1:exon
subclass of: SO_0000010

854170
type: Gene
SIO_000068: ncbigene

position:341278:-1
position: 341278
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:342414:-1
position: 342414
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341278-342414:-1:exon

YOR008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HCS77
alternative label: WSC1
gene: SLG1
locus tag: YOR008C
gene synonym: HCS77; WSC1
product: Slg1p
transcript id: NM_001183427.1
SIO_010081: YOR008C
subclass of: SO_0000673
so part of: YOR008C
location: complement(<341278..>342414)
location: region:341278-342414:-1
so has part: feature:341278-342414:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341278-342414:-1:exon

YOR008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HCS77
alternative label: WSC1
gene: SLG1
locus tag: YOR008C
gene synonym: HCS77; WSC1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9391108|PMID:20652590]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17761172]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]
experiment: EXISTENCE:genetic interaction:GO:0006970 response to osmotic stress [PMID:14871941]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:30361468]
experiment: EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843|PMID:10508863]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843|PMID:10508863]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:10508863|PMID:24326069]
experiment: EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:10508863]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:20385774]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10348843]
experiment: EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073|PMID:24326069]
note: Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
codon start: 1
product: Slg1p
translation: MRPNKTSLLLALLSILSQANAYEYVNCFSSLPSDFSKADSYNWQSSSHCNSECSAKGASYFALYNHSECYCGDTNPSGSESTSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSASSSTTSSTTSSTTSTTSSTTSSTTSSMASSSTVQNSPESTQAAASISTSQSSSTVTSESSLTSDTLATSSTSSQSQDATSIIYSTTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTHKKKANVGAIVGGVVGGVVGAVAIALCILLIVRHINMKREQDRMEKEYQEAIKPVEYPDKLYASSFSSNHGPSSGSFEEEHTKGQTDINPFDDSRRISNGTFINGGPGGKNNVLTVVNPDEAD
SIO_010081: YOR008C
subclass of: SO_0000673
so part of: YOR008C
location: complement(341278..342414)
location: region:341278-342414:-1
so has part: feature:341278-342414:-1:exon

NP_014650.1
type: Protein
SIO_000068: ncbiprotein

S000005534
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341278-342414:-1:exon

YOR008C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR008C-A
so part of: sequence
location: complement(<342857..>343081)
location: region:342857-343081:-1
so has part: feature:342857-343081:-1:exon
subclass of: SO_0000010

854171
type: Gene
SIO_000068: ncbigene

position:342857:-1
position: 342857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343081:-1
position: 343081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342857-343081:-1:exon

YOR008C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR008C-A
product: uncharacterized protein
transcript id: NM_001184305.1
SIO_010081: YOR008C-A
subclass of: SO_0000673
so part of: YOR008C-A
location: complement(<342857..>343081)
location: region:342857-343081:-1
so has part: feature:342857-343081:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342857-343081:-1:exon

YOR008C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR008C-A
note: hypothetical protein; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively
codon start: 1
product: uncharacterized protein
translation: MWRSYLVFLFFMTPRIQTYCPVPVLRSMAVLNIISPLIIFVSPIKKQDSLHSSACYANLTLVEKLQLWHSMSND
SIO_010081: YOR008C-A
subclass of: SO_0000673
so part of: YOR008C-A
location: complement(342857..343081)
location: region:342857-343081:-1
so has part: feature:342857-343081:-1:exon

NP_014651.1
type: Protein
SIO_000068: ncbiprotein

S000006431
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342857-343081:-1:exon

YOR009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIR4
locus tag: YOR009W
so part of: sequence
location: <344335..>345798
location: region:344335-345798:1
so has part: feature:344335-345798:1:exon
subclass of: SO_0000010

854173
type: Gene
SIO_000068: ncbigene

position:344335:1
position: 344335
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345798:1
position: 345798
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:344335-345798:1:exon

YOR009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIR4
locus tag: YOR009W
product: Tir4p
transcript id: NM_001183428.1
SIO_010081: YOR009W
subclass of: SO_0000673
so part of: YOR009W
location: <344335..>345798
location: region:344335-345798:1
so has part: feature:344335-345798:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:344335-345798:1:exon

YOR009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIR4
locus tag: YOR009W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
codon start: 1
product: Tir4p
translation: MAYSKITLLAALAAIAYAQTQAQINELNVVLDDVKTNIADYITLSYTPNSGFSLDQMPAGIMDIAAQLVANPSDDSYTTLYSEVDFSAVEHMLTMVPWYSSRLLPELEAMDASLTTSSSAATSSSEVASSSIASSTSSSVAPSSSEVVSSSVAPSSSEVVSSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVAPSSSEVVSSSVASSSSEVASSSVAPSSSEVVSSSVASSTSEATSSSAVTSSSAVSSSTESVSSSSVSSSSAVSSSEAVSSSPVSSVVSSSAGPASSSVAPYNSTIASSSSTAQTSISTIAPYNSTTTTTPASSASSVIISTRNGTTVTETDNTLVTKETTVCDYSSTSAVPASTTGYNNSTKVSTATICSTCKEGTSTATDFSTLKTTVTVCDSACQAKKSATVVSVQSKTTGIVEQTENGAAKAVIGMGAGALAAVAAMLL
SIO_010081: YOR009W
subclass of: SO_0000673
so part of: YOR009W
location: 344335..345798
location: region:344335-345798:1
so has part: feature:344335-345798:1:exon

NP_014652.1
type: Protein
SIO_000068: ncbiprotein

S000005535
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:344335-345798:1:exon

YOR010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SRP2
gene: TIR2
locus tag: YOR010C
gene synonym: SRP2
so part of: sequence
location: complement(<346195..>346950)
location: region:346195-346950:-1
so has part: feature:346195-346950:-1:exon
subclass of: SO_0000010

854174
type: Gene
SIO_000068: ncbigene

position:346195:-1
position: 346195
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346950:-1
position: 346950
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346195-346950:-1:exon

YOR010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SRP2
gene: TIR2
locus tag: YOR010C
gene synonym: SRP2
product: putative GPI-anchored mannoprotein
transcript id: NM_001183429.1
SIO_010081: YOR010C
subclass of: SO_0000673
so part of: YOR010C
location: complement(<346195..>346950)
location: region:346195-346950:-1
so has part: feature:346195-346950:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346195-346950:-1:exon

YOR010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SRP2
gene: TIR2
locus tag: YOR010C
gene synonym: SRP2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071497 cellular response to freezing [PMID:7746155]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication
codon start: 1
product: putative GPI-anchored mannoprotein
translation: MAYIKIALLAAIAALASAQTQEEIDELNVILNDVKSNLQEYISLAEDSSSGFSLSSLPSGVLDIGLALASATDDSYTTLYSEVDFAAVSKMLTMVPWYSSRLLPELESLLGTSTTAASSTEASSAATSSAVASSSETTSSAVASSSEATSSAVASSSEASSSAATSSAVASSSEATSSTVASSTKAASSTKASSSAVSSAVASSTKASAISQISDGQVQATSTVSEQTENGAAKAVIGMGAGVMAAAAMLL
SIO_010081: YOR010C
subclass of: SO_0000673
so part of: YOR010C
location: complement(346195..346950)
location: region:346195-346950:-1
so has part: feature:346195-346950:-1:exon

NP_014653.1
type: Protein
SIO_000068: ncbiprotein

S000005536
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346195-346950:-1:exon

YOR011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AUS1
locus tag: YOR011W
so part of: sequence
location: <349679..>353863
location: region:349679-353863:1
so has part: feature:349679-353863:1:exon
subclass of: SO_0000010

854175
type: Gene
SIO_000068: ncbigene

position:349679:1
position: 349679
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:353863:1
position: 353863
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349679-353863:1:exon

YOR011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AUS1
locus tag: YOR011W
product: ATP-binding cassette sterol transporter AUS1
transcript id: NM_001183430.1
SIO_010081: YOR011W
subclass of: SO_0000673
so part of: YOR011W
location: <349679..>353863
location: region:349679-353863:1
so has part: feature:349679-353863:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349679-353863:1:exon

YOR011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AUS1
locus tag: YOR011W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21521689]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0035376 sterol import [PMID:21110944|PMID:12077145]
experiment: EXISTENCE:mutant phenotype:GO:0034041 ABC-type sterol transporter activity [PMID:21521689]
experiment: EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:21521689|PMID:12077145]
note: Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication
codon start: 1
product: ATP-binding cassette sterol transporter AUS1
translation: MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSRGSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVIVFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLAIAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDVPFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSPYTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVCAYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKIITKVIPHRGKKPVQN
SIO_010081: YOR011W
subclass of: SO_0000673
so part of: YOR011W
location: 349679..353863
location: region:349679-353863:1
so has part: feature:349679-353863:1:exon

NP_014654.1
type: Protein
SIO_000068: ncbiprotein

S000005537
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349679-353863:1:exon

YNCO0013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0013C
so part of: sequence
location: complement(354041..354113)
location: region:354041-354113:-1
so has part: feature:354041-354113:-1:exon
subclass of: SO_0000663

854176
type: Gene
SIO_000068: ncbigene

position:354041:-1
position: 354041
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:354113:-1
position: 354113
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354041-354113:-1:exon

YNCO0013C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0013C
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0013C
subclass of: SO_0000673
so part of: YNCO0013C
location: complement(354041..354113)
location: region:354041-354113:-1
so has part: feature:354041-354113:-1:exon

S000006747
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:354041-354113:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 354128..354466
location: region:354128-354466:1
so has part: feature:354128-354466:1:region

S000007159
type: SGD
SIO_000068: sgd

position:354128:1
position: 354128
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:354466:1
position: 354466
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354128-354466:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 354681..354958
location: region:354681-354958:1
so has part: feature:354681-354958:1:region

S000007157
type: SGD
SIO_000068: sgd

position:354681:1
position: 354681
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:354958:1
position: 354958
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354681-354958:1:region

YOR011W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR011W-A
so part of: sequence
location: <355652..>355858
location: region:355652-355858:1
so has part: feature:355652-355858:1:exon
subclass of: SO_0000010

1466479
type: Gene
SIO_000068: ncbigene

position:355652:1
position: 355652
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:355858:1
position: 355858
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:355652-355858:1:exon

YOR011W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR011W-A
product: uncharacterized protein
transcript id: NM_001184576.1
SIO_010081: YOR011W-A
subclass of: SO_0000673
so part of: YOR011W-A
location: <355652..>355858
location: region:355652-355858:1
so has part: feature:355652-355858:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:355652-355858:1:exon

YOR011W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR011W-A
codon start: 1
product: uncharacterized protein
translation: MAKSVFNFFHFEILEYLNRFVYHSQYFLPYYCSLEVLGKSRKNWTFQYWCLYITTDKKIIKKKDFYHR
SIO_010081: YOR011W-A
subclass of: SO_0000673
so part of: YOR011W-A
location: 355652..355858
location: region:355652-355858:1
so has part: feature:355652-355858:1:exon

NP_878167.1
type: Protein
SIO_000068: ncbiprotein

S000028581
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:355652-355858:1:exon

YOR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR012W
so part of: sequence
location: <356543..>356956
location: region:356543-356956:1
so has part: feature:356543-356956:1:exon
subclass of: SO_0000010

854177
type: Gene
SIO_000068: ncbigene

position:356543:1
position: 356543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356956:1
position: 356956
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:356543-356956:1:exon

YOR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR012W
product: uncharacterized protein
transcript id: NM_001183431.1
SIO_010081: YOR012W
subclass of: SO_0000673
so part of: YOR012W
location: <356543..>356956
location: region:356543-356956:1
so has part: feature:356543-356956:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:356543-356956:1:exon

YOR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR012W
codon start: 1
product: uncharacterized protein
translation: MVASSINEESSLAVNLTSDVEKASKTLFKAFEKSYANDYLMKKFFHIPITEKVSRARINAMIHYYTTCYHDLDGEIAEANDFDAVAIWSRPGCHLPATLSDDESFNKIFFSRLDCEEARSHASGNGLLLPLCHRKRS
SIO_010081: YOR012W
subclass of: SO_0000673
so part of: YOR012W
location: 356543..356956
location: region:356543-356956:1
so has part: feature:356543-356956:1:exon

NP_014655.1
type: Protein
SIO_000068: ncbiprotein

S000005538
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:356543-356956:1:exon

YOR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCS1
gene: RTS1
locus tag: YOR014W
gene synonym: SCS1
so part of: sequence
location: <357674..>359947
location: region:357674-359947:1
so has part: feature:357674-359947:1:exon
subclass of: SO_0000010

854179
type: Gene
SIO_000068: ncbigene

position:357674:1
position: 357674
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:359947:1
position: 359947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357674-359947:1:exon

YOR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCS1
gene: RTS1
locus tag: YOR014W
gene synonym: SCS1
product: protein phosphatase 2A regulatory subunit RTS1
transcript id: NM_001183433.1
SIO_010081: YOR014W
subclass of: SO_0000673
so part of: YOR014W
location: <357674..>359947
location: region:357674-359947:1
so has part: feature:357674-359947:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:357674-359947:1:exon

YOR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCS1
gene: RTS1
locus tag: YOR014W
gene synonym: SCS1
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:25236599]
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:12636916|PMID:23785440]
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16541024]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:31781172]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12388751|PMID:12636916|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12388751]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12388751|PMID:12636916]
experiment: EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:9079645]
experiment: EXISTENCE:genetic interaction:GO:0031134 sister chromatid biorientation [PMID:25236599]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:19605686]
experiment: EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]
experiment: EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:31781172]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:19605686]
experiment: EXISTENCE:mutant phenotype:GO:0031107 septin ring disassembly [PMID:12636916]
experiment: EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]
experiment: EXISTENCE:mutant phenotype:GO:0051754 meiotic sister chromatid cohesion, centromeric [PMID:16541024]
experiment: EXISTENCE:mutant phenotype:GO:0070199 establishment of protein localization to chromosome [PMID:24945276]
note: B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
codon start: 1
product: protein phosphatase 2A regulatory subunit RTS1
translation: MMRGFKQRLIKKTTGSSSSSSSKKKDKEKEKEKSSTTSSTSKKPASASSSSHGTTHSSASSTGSKSTTEKGKQSGSVPSQGKHHSSSTSKTKTATTPSSSSSSSRSSSVSRSGSSSTKKTSSRKGQEQSKQSQQPSQSQKQGSSSSSAAIMNPTPVLTVTKDDKSTSGEDHAHPTLLGAVSAVPSSPISNASGTAVSSDVENGNSNNNNMNINTSNTQDANHASSQSIDIPRSSHSFERLPTPTKLNPDTDLELIKTPQRHSSSRFEPSRYTPLTKLPNFNEVSPEERIPLFIAKVDQCNTMFDFNDPSFDIQGKEIKRSTLDELIEFLVTNRFTYTNEMYAHVVNMFKINLFRPIPPPVNPVGDIYDPDEDEPVNELAWPHMQAVYEFFLRFVESPDFNHQIAKQYIDQDFILKLLELFDSEDIRERDCLKTTLHRIYGKFLSLRSFIRRSMNNIFLQFIYETEKFNGVAELLEILGSIINGFALPLKEEHKVFLVRILIPLHKVRCLSLYHPQLAYCIVQFLEKDPLLTEEVVMGLLRYWPKINSTKEIMFLNEIEDIFEVIEPLEFIKVEVPLFVQLAKCISSPHFQVAEKVLSYWNNEYFLNLCIENAEVILPIIFPALYELTSQLELDTANGEDSISDPYMLVEQAINSGSWNRAIHAMAFKALKIFLETNPVLYENCNALYLSSVKETQQRKVQREENWSKLEEYVKNLRINNDKDQYTIKNPELRNSFNTASENNTLNEENENDCDSEIQ
SIO_010081: YOR014W
subclass of: SO_0000673
so part of: YOR014W
location: 357674..359947
location: region:357674-359947:1
so has part: feature:357674-359947:1:exon

NP_014657.1
type: Protein
SIO_000068: ncbiprotein

S000005540
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:357674-359947:1:exon

YOR015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR015W
so part of: sequence
location: <359993..>360352
location: region:359993-360352:1
so has part: feature:359993-360352:1:exon
subclass of: SO_0000010

854180
type: Gene
SIO_000068: ncbigene

position:359993:1
position: 359993
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360352:1
position: 360352
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359993-360352:1:exon

YOR015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR015W
product: uncharacterized protein
transcript id: NM_001348876.1
SIO_010081: YOR015W
subclass of: SO_0000673
so part of: YOR015W
location: <359993..>360352
location: region:359993-360352:1
so has part: feature:359993-360352:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359993-360352:1:exon

YOR015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR015W
note: hypothetical protein; conserved among S. cerevisiae strains; YOR015W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MPHFKRAAVYEEQKRTGKWGQLVEETKDRIPEYSNKTIAKISHLDNGCLWPEIKVSFSHHLSILQSMCLHFIISILFSKYIFVFLFAFLLPSAFPLFILHSTLFRKPCLSIIGFLKTKV
SIO_010081: YOR015W
subclass of: SO_0000673
so part of: YOR015W
location: 359993..360352
location: region:359993-360352:1
so has part: feature:359993-360352:1:exon

NP_001335814.1
type: Protein
SIO_000068: ncbiprotein

S000005541
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359993-360352:1:exon

YOR016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERP4
locus tag: YOR016C
so part of: sequence
location: complement(<360461..>361084)
location: region:360461-361084:-1
so has part: feature:360461-361084:-1:exon
subclass of: SO_0000010

854181
type: Gene
SIO_000068: ncbigene

position:360461:-1
position: 360461
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361084:-1
position: 361084
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360461-361084:-1:exon

YOR016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERP4
locus tag: YOR016C
product: Erp4p
transcript id: NM_001183435.1
SIO_010081: YOR016C
subclass of: SO_0000673
so part of: YOR016C
location: complement(<360461..>361084)
location: region:360461-361084:-1
so has part: feature:360461-361084:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360461-361084:-1:exon

YOR016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERP4
locus tag: YOR016C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]
note: Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication
codon start: 1
product: Erp4p
translation: MRVFTLIAILFSSSLLTHAFSSNYAPVGISLPAFTKECLYYDLSSDKDVLVVSYQVLTGGNFEIDFDITAPDGSVIVTERQKKHSDFLLKSFGIGKYTFCLSNNYGTSPKKVEITLEKEKEIVSSHESKEDIIANNAIEEIDRNLNKITKTMDYLRAREWRNMYTVSSTESRLTWLSLLIMGVMVGISIVQALIIQFFFTSRQKNYV
SIO_010081: YOR016C
subclass of: SO_0000673
so part of: YOR016C
location: complement(360461..361084)
location: region:360461-361084:-1
so has part: feature:360461-361084:-1:exon

NP_014659.1
type: Protein
SIO_000068: ncbiprotein

S000005542
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360461-361084:-1:exon

YOR017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PET127
locus tag: YOR017W
so part of: sequence
location: <361412..>363814
location: region:361412-363814:1
so has part: feature:361412-363814:1:exon
subclass of: SO_0000010

854182
type: Gene
SIO_000068: ncbigene

position:361412:1
position: 361412
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:363814:1
position: 363814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:361412-363814:1:exon

YOR017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PET127
locus tag: YOR017W
product: Pet127p
transcript id: NM_001183436.1
SIO_010081: YOR017W
subclass of: SO_0000673
so part of: YOR017W
location: <361412..>363814
location: region:361412-363814:1
so has part: feature:361412-363814:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:361412-363814:1:exon

YOR017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PET127
locus tag: YOR017W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:9111353]
experiment: EXISTENCE:mutant phenotype:GO:0000964 mitochondrial RNA 5'-end processing [PMID:18086665|PMID:9111353]
note: Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane
codon start: 1
product: Pet127p
translation: MGFYNCRFLSRRLSVEPCRIGSAAKSYQQRSIYHFGAALTNAPSGRETPDKLRSDLHSALEMVDEIYDTNSTVEDIGNKEKGGRQKYTEEMDKAINLLKTNIKKEYRHDKYLERTKVGTYPGRRTYPGRRTYPARRTYPASRTYSDSNSYTFRINVQKIRHALVRYNQDGVQKHNQKPPRIGHGLTRVLYQPLSLQKLRDNRSRMYNFDPAVENINPEYLEKKSEKDVNTDSSGEGQSKPIFITPHKDESLLKVAKEHRKKYISSSSSMTSVLSQLHYLLSNFRRLNIIDSSISKNFPQKNCNYSESAYFPSAVILRKKRNGICSIDSDRSLDREIVLSVLGHYLEDFLTEKSLKNSSKSENYHYSSIDEFIVRSQLDAYDPNLPGTGVFDLKTRAVSAIRYDLSHVESNNNQTGYEIDKVYGEFESLEREYFELIRSALLKYSLQARIGKMDGIFVAYHNISKMFGFQYLPLDELDYIIHSSYNSKFDSLLKEKNDITKGIYGEEDYILHYDRDDRKIACLVANREFKMSMNLFSNILKHVEQLLNSSNTKWEKCKIMLKTEVEEKRSKSGRFFNEPVLNIVALPLSPEYEDKSLLVKDTSNEQLTEELLNLRSYNENLLEEHLNSLVGFKVNVKHFYHHHPNTTHLPDFALKKNDILDTESRKYISDMMKRDWYKDIPSTQTPNFFHASDVSTWEVNSTFTDINDKQILRKLYFKYLDVKLNALKNQVITRQEPDMSKKDEIMNRIKSLQARNDHRDNGSNKRYSNFGPTRLQTKLRAYAKKGALRRKLLERSNKFHI
SIO_010081: YOR017W
subclass of: SO_0000673
so part of: YOR017W
location: 361412..363814
location: region:361412-363814:1
so has part: feature:361412-363814:1:exon

NP_014660.1
type: Protein
SIO_000068: ncbiprotein

S000005543
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:361412-363814:1:exon

YOR018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ART4
gene: ROD1
locus tag: YOR018W
gene synonym: ART4
so part of: sequence
location: <364369..>366882
location: region:364369-366882:1
so has part: feature:364369-366882:1:exon
subclass of: SO_0000010

854183
type: Gene
SIO_000068: ncbigene

position:364369:1
position: 364369
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:366882:1
position: 366882
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364369-366882:1:exon

YOR018W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ART4
gene: ROD1
locus tag: YOR018W
gene synonym: ART4
product: Rod1p
transcript id: NM_001183437.1
SIO_010081: YOR018W
subclass of: SO_0000673
so part of: YOR018W
location: <364369..>366882
location: region:364369-366882:1
so has part: feature:364369-366882:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:364369-366882:1:exon

YOR018W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ART4
gene: ROD1
locus tag: YOR018W
gene synonym: ART4
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8621680]
experiment: EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]
experiment: EXISTENCE:direct assay:GO:0071333 cellular response to glucose stimulus [PMID:22249293]
experiment: EXISTENCE:genetic interaction:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:24820415]
experiment: EXISTENCE:genetic interaction:GO:0002092 positive regulation of receptor internalization [PMID:24820415]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:24820415]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:12163175]
experiment: EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]
experiment: EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:22249293]
experiment: EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]
note: Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
codon start: 1
product: Rod1p
translation: MFSSSSRPSKEPLLFDIRLRNLDNDVLLIKGPPDEASSVLLSGTIVLSITEPIQIKSLALRLFGRLRLNIPTVLQTVHGPHKRYSKFERNIYSHFWDDFNIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTASLISSNGQTSASKNYHTLVKGNYEFPFSAIIPGSLVESVEGLPNAAVTYALEATIERPKQPDLICKKHLRVIRTLAIDAVELSETVSVDNSWPEKVDYTISIPTKAIAIGSSTMINILIVPILKGLKLGPVRISLVENSQYCGSYGGVINQERMVAKLKLKDPLKHVAQIKKKRSLNEAADEGVDTDTGEFQDKWEVRALLNIPASLTKCSQDCRILSNIKVRHKIKFTISLLNPDGHISELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSYQVTSQHDNSFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTMVTSLMVPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQNLYISDSNNSNNPILAPNPQIKIEDDSLNNCDSRGDSVNNSNLNLVNSNLTISENWNNNSPSANRYNNIINAGLNSPSLTPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLPPAYPEEELGVQENKKIELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSPLPRNNSGSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFPFNMTTSFTSNSSSKNNSHFDKTDSTSDANKPREEENYTSATHNRRSRSSSVRSNNSNSPLRQGTGSFANLMEMFTKRDRS
SIO_010081: YOR018W
subclass of: SO_0000673
so part of: YOR018W
location: 364369..366882
location: region:364369-366882:1
so has part: feature:364369-366882:1:exon

NP_014661.1
type: Protein
SIO_000068: ncbiprotein

S000005544
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:364369-366882:1:exon

YOR019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR019W
so part of: sequence
location: <368127..>370319
location: region:368127-370319:1
so has part: feature:368127-370319:1:exon
subclass of: SO_0000010

854184
type: Gene
SIO_000068: ncbigene

position:368127:1
position: 368127
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370319:1
position: 370319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368127-370319:1:exon

YOR019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR019W
product: uncharacterized protein
transcript id: NM_001183438.1
SIO_010081: YOR019W
subclass of: SO_0000673
so part of: YOR019W
location: <368127..>370319
location: region:368127-370319:1
so has part: feature:368127-370319:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368127-370319:1:exon

YOR019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR019W
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MISVCPQNDLQKCYRSLTFDVPGQQFEERNEQNLKKRAKKKGSFQPSVAFDTVPSTAGYSSIDDSREGFKGVPVPNYYTMEECYDDETDSFSPNLQYYLRDTFQSSPFLNTRKENKSESSSFPMRSSKLLEKNSDIKKYFLVSKNGKIVRRDYPSTPVIVNETLMINRFEKNWIKLWRQRKLQINERLNDKKKWFTYPELIFSEERIKPLYRGDDSAPCTKEQKRKHKILQQKVGYPNNPKTIVCHINGKKHTWVALDWTVYKFARNLDHIVVITTLPKMISNRKKTAKDDTEWAPGYQKEVIDQKLNDIFDYILQLVKVVKISVKITLEIIVGKIKKSLVDVINVHTPDFLVLATLKHERNENLITYKSKKLTDVFPVSYPIPTFVVPSKRMYSFELNLQREVNEHYVSKNHMKHEHTDVESMSSSMFKKNTISDISSHISVDSYAEDFKRQGYIKKQFNTSNDSIPRKLTGLAQHSRRKITGDIEKLQDDEKDRECTKEKLLLKKIDIIIRESLKSSLAIETLPGKNVSQSSHGDQISSFKNALIGNGSKNTKFRKSLIPYSSSEEQNTTTTIKLSSSPTSQIKFATSVKHKDGRAALGKARNLPDIRHSISFDKENSFDPSDKSSSVDNSIPLRKVKSAGALRKVKTNDSSSSAGSKKSSSSFSTVNTFTGGGVGIFKVFKSGSSSGNKSSSRRNSSSGDVFESDDRNDKKKKKKKKKKSLFLFGKI
SIO_010081: YOR019W
subclass of: SO_0000673
so part of: YOR019W
location: 368127..370319
location: region:368127-370319:1
so has part: feature:368127-370319:1:exon

NP_014662.1
type: Protein
SIO_000068: ncbiprotein

S000005545
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368127-370319:1:exon

YOR020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPN10
gene: HSP10
locus tag: YOR020C
gene synonym: CPN10
so part of: sequence
location: complement(<370524..>370844)
location: region:370524-370844:-1
so has part: feature:370524-370844:-1:exon
subclass of: SO_0000010

854185
type: Gene
SIO_000068: ncbigene

position:370524:-1
position: 370524
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370844:-1
position: 370844
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370524-370844:-1:exon

YOR020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPN10
gene: HSP10
locus tag: YOR020C
gene synonym: CPN10
product: Hsp10p
transcript id: NM_001183439.1
SIO_010081: YOR020C
subclass of: SO_0000673
so part of: YOR020C
location: complement(<370524..>370844)
location: region:370524-370844:-1
so has part: feature:370524-370844:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370524-370844:-1:exon

YOR020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPN10
gene: HSP10
locus tag: YOR020C
gene synonym: CPN10
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:7903252]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7902576]
experiment: EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9256426]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:7902576]
experiment: EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:9256426]
experiment: EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:7913473]
experiment: EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:7913473]
experiment: EXISTENCE:physical interaction:GO:0051087 chaperone binding [PMID:9256426]
note: Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
codon start: 1
product: Hsp10p
translation: MSTLLKSAKSIVPLMDRVLVQRIKAQAKTASGLYLPEKNVEKLNQAEVVAVGPGFTDANGNKVVPQVKVGDQVLIPQFGGSTIKLGNDDEVILFRDAEILAKIAKD
SIO_010081: YOR020C
subclass of: SO_0000673
so part of: YOR020C
location: complement(370524..370844)
location: region:370524-370844:-1
so has part: feature:370524-370844:-1:exon

NP_014663.1
type: Protein
SIO_000068: ncbiprotein

S000005546
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370524-370844:-1:exon

YOR020W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCO10
locus tag: YOR020W-A
so part of: sequence
location: <371685..>371957
location: region:371685-371957:1
so has part: feature:371685-371957:1:exon
subclass of: SO_0000010

1466480
type: Gene
SIO_000068: ncbigene

position:371685:1
position: 371685
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371957:1
position: 371957
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371685-371957:1:exon

YOR020W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCO10
locus tag: YOR020W-A
product: Mco10p
transcript id: NM_001184536.1
SIO_010081: YOR020W-A
subclass of: SO_0000673
so part of: YOR020W-A
location: <371685..>371957
location: region:371685-371957:1
so has part: feature:371685-371957:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371685-371957:1:exon

YOR020W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCO10
locus tag: YOR020W-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]
note: Mitochondrial hypothetical protein; conserved in A. gossypii; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Mco10p
translation: MGAAYKVFGKTVQPHVLAISTFIATAAVASYFTTKPKTKNEGKNSSALSQQKSGESSNSDAMGKDDDVVKSIEGFLNDLEKDTRQDTKAN
SIO_010081: YOR020W-A
subclass of: SO_0000673
so part of: YOR020W-A
location: 371685..371957
location: region:371685-371957:1
so has part: feature:371685-371957:1:exon

NP_878168.1
type: Protein
SIO_000068: ncbiprotein

S000028526
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371685-371957:1:exon

YOR021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SFM1
locus tag: YOR021C
so part of: sequence
location: complement(<372798..>373439)
location: region:372798-373439:-1
so has part: feature:372798-373439:-1:exon
subclass of: SO_0000010

854186
type: Gene
SIO_000068: ncbigene

position:372798:-1
position: 372798
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:373439:-1
position: 373439
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372798-373439:-1:exon

YOR021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SFM1
locus tag: YOR021C
product: protein-arginine N-methyltransferase SFM1
transcript id: NM_001183440.1
SIO_010081: YOR021C
subclass of: SO_0000673
so part of: YOR021C
location: complement(<372798..>373439)
location: region:372798-373439:-1
so has part: feature:372798-373439:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372798-373439:-1:exon

YOR021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SFM1
locus tag: YOR021C
experiment: EXISTENCE:direct assay:GO:0035241 protein-arginine omega-N monomethyltransferase activity [PMID:22650761]
experiment: EXISTENCE:mutant phenotype:GO:0018216 peptidyl-arginine methylation [PMID:22650761]
note: SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
codon start: 1
product: protein-arginine N-methyltransferase SFM1
translation: MKYIIEHMEEGFSEWVILEYSQILREVGAENLILSSLPESTTEKDIPQRLLKLGLRWTTKDLKGINEDFKDLELLKDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYPNLLISRRLGDKQMTTDTAIRTTQLIIKDRIAFEDIKFIDYPEFRFNKNEATEMPFRYVLDKEGKPILPEGMLDLIKKDSAQSLDDLLM
SIO_010081: YOR021C
subclass of: SO_0000673
so part of: YOR021C
location: complement(372798..373439)
location: region:372798-373439:-1
so has part: feature:372798-373439:-1:exon

NP_014664.1
type: Protein
SIO_000068: ncbiprotein

S000005547
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372798-373439:-1:exon

YOR022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DDL1
locus tag: YOR022C
so part of: sequence
location: complement(<373710..>375857)
location: region:373710-375857:-1
so has part: feature:373710-375857:-1:exon
subclass of: SO_0000010

854187
type: Gene
SIO_000068: ncbigene

position:373710:-1
position: 373710
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:375857:-1
position: 375857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373710-375857:-1:exon

YOR022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DDL1
locus tag: YOR022C
product: putative carboxylic ester hydrolase
transcript id: NM_001183441.1
SIO_010081: YOR022C
subclass of: SO_0000673
so part of: YOR022C
location: complement(<373710..>375857)
location: region:373710-375857:-1
so has part: feature:373710-375857:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:373710-375857:-1:exon

YOR022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DDL1
locus tag: YOR022C
experiment: EXISTENCE:direct assay:GO:0004620 phospholipase activity [PMID:27402848|PMID:27746179]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:27746179]
experiment: EXISTENCE:mutant phenotype:GO:0004620 phospholipase activity [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0046337 phosphatidylethanolamine metabolic process [PMID:27402848]
note: DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism
codon start: 1
product: putative carboxylic ester hydrolase
translation: MLRFTHRGLPSSTRFRNIFVRLNHIYVPWFYAIDVPNSKPYLPTYQTLHSPKKFKPFSVDDSNRLEKASKRQERRPVLVNEDYLFKVDLSHMELSPTYWEGPTYQVRRGVWFDSSNQPLSSDLTSEIEGLYKQLKFDDSNDDPTTTPPAESQDIFRLKGKYPVDKENEGEQKNGSSNKDENESTFKFILFANKQTAFLLSDLDGGKLQLAFLRSNLAQSLPINATMITRSYKYSSSATTKQTSTSFKAAKTPQTEVADGSNSSKSRSIETKLEKKVSNLFNLSDFLQLFNGNASKDQDDAQSLEKQMETDYNNADNSQGANASSKIEDGKNSGASDRQIRSNRRDVDNLILCVHGIGQTLGKKYEYVNFAHTVNLLRSNMKKIYNNSEKLQSLNTAPDYKSNCNVQVLPITWRHSISFQTDAKEENIENPDLPTLSQVTVNGVLPLRKLLADGLLDILLYVEPYYQDMILQQVTSQLNKTYRIFKEFNPEFDGKVHLVGHSLGSMILFDILSKQKKYELEFQVDNLFFIGSPIGLLKLIQRTKIGDRPEFPNDLERKLTVQRPQCKDIYNVYHVCDPISYRMEPLVSKEMAHYEQTYLPHCSEAYGLTSKVLEFGENIWKDLPGTDENNLQSKKTSPEKKEVKLSENLTRMLTGLNYTGRLDYAMSPSLLEVDFISAIKSHVSYFEEPDIAAFILKEILSKHENASEIYVKRKTG
SIO_010081: YOR022C
subclass of: SO_0000673
so part of: YOR022C
location: complement(373710..375857)
location: region:373710-375857:-1
so has part: feature:373710-375857:-1:exon

NP_014665.1
type: Protein
SIO_000068: ncbiprotein

S000005548
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:373710-375857:-1:exon

YOR023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AHC1
locus tag: YOR023C
so part of: sequence
location: complement(<376012..>377712)
location: region:376012-377712:-1
so has part: feature:376012-377712:-1:exon
subclass of: SO_0000010

854188
type: Gene
SIO_000068: ncbigene

position:376012:-1
position: 376012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:377712:-1
position: 377712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:376012-377712:-1:exon

YOR023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AHC1
locus tag: YOR023C
product: Ahc1p
transcript id: NM_001183442.1
SIO_010081: YOR023C
subclass of: SO_0000673
so part of: YOR023C
location: complement(<376012..>377712)
location: region:376012-377712:-1
so has part: feature:376012-377712:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:376012-377712:-1:exon

YOR023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AHC1
locus tag: YOR023C
experiment: EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10490601]
experiment: EXISTENCE:direct assay:GO:0140671 ADA complex [PMID:10490601]
experiment: EXISTENCE:mutant phenotype:GO:0016573 histone acetylation [PMID:10490601]
experiment: EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]
note: Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex
codon start: 1
product: Ahc1p
translation: MMSPAQDKLQHQHHNPNSSSSSSSKMTNVYQVTTPKSPQDLENNMDEPFKMDTATSNPDKDSENTQRLKYECAKGEIQNVLNLHIMLNHKHVRHLRRNVQKVNAKLALLETLHKDTGLLNKIERTYQLKIKQHQQHSVLGGHFHDSTATENTNASNYNLSYPVLSDYNINCQPLSSSSNRNLSTTRIPHHHYHTRSKSNGLLLEPSALRPANSNIIDYRLTGSKSLSEAITKPTPVSLPHSNSDGISSPRSSSISPLDEQPGFQILPFKPSQMHLNHRRNYSSTCLTSNSGIIGKTENNEPIFRRYDGILVIITCSKCDRSGFTSAQGIVNHTRLKHSKLYSSQPLAVLNNQKLLPNDKQDPEILSKFKKLNLDPNKDYLPSDIAIPKPQSPINHSENHTRAPKTVKNTPHLEKLYQNKEDFKKLIDMVNETPDDLNEYLKQREIQLRYQKEQEEESSKSDDEASYVPSPSLSATATTTTTTDPPSPPVLSSSLQRKLLRKRKLSLNSSTPMEDLPLRERLRANPTDKKPRKAALLTNELEGPDPAAKSSSYYNLRSKSRLRGSHT
SIO_010081: YOR023C
subclass of: SO_0000673
so part of: YOR023C
location: complement(376012..377712)
location: region:376012-377712:-1
so has part: feature:376012-377712:-1:exon

NP_014666.1
type: Protein
SIO_000068: ncbiprotein

S000005549
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:376012-377712:-1:exon

YOR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HST3
locus tag: YOR025W
so part of: sequence
location: <378219..>379562
location: region:378219-379562:1
so has part: feature:378219-379562:1:exon
subclass of: SO_0000010

854190
type: Gene
SIO_000068: ncbigene

position:378219:1
position: 378219
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:379562:1
position: 379562
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379562:1:exon

YOR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HST3
locus tag: YOR025W
product: NAD-dependent histone deacetylase HST3
transcript id: NM_001183444.1
SIO_010081: YOR025W
subclass of: SO_0000673
so part of: YOR025W
location: <378219..>379562
location: region:378219-379562:1
so has part: feature:378219-379562:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379562:1:exon

YOR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HST3
locus tag: YOR025W
EC number: 2.3.1.286
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12242223]
experiment: EXISTENCE:direct assay:GO:0009299 mRNA transcription [PMID:31167142]
experiment: EXISTENCE:direct assay:GO:0017136 NAD-dependent histone deacetylase activity [PMID:17977840]
experiment: EXISTENCE:direct assay:GO:0098781 ncRNA transcription [PMID:31167142]
experiment: EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7498786]
experiment: EXISTENCE:mutant phenotype:GO:0017136 NAD-dependent histone deacetylase activity [PMID:17977840]
experiment: EXISTENCE:mutant phenotype:GO:0046459 short-chain fatty acid metabolic process [PMID:12618394]
experiment: EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]
note: Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases
codon start: 1
product: NAD-dependent histone deacetylase HST3
translation: MTSVSPSPPASRSGSMCSDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQMKAQKDSIGTPPTTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEEDEEENLDTRKRAKIRPTFGDNQAS
SIO_010081: YOR025W
subclass of: SO_0000673
so part of: YOR025W
location: 378219..379562
location: region:378219-379562:1
so has part: feature:378219-379562:1:exon

NP_014668.1
type: Protein
SIO_000068: ncbiprotein

S000005551
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379562:1:exon

YOR026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAC9
gene: BUB3
locus tag: YOR026W
gene synonym: PAC9
so part of: sequence
location: <379781..>380806
location: region:379781-380806:1
so has part: feature:379781-380806:1:exon
subclass of: SO_0000010

854191
type: Gene
SIO_000068: ncbigene

position:379781:1
position: 379781
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:380806:1
position: 380806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379781-380806:1:exon

YOR026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAC9
gene: BUB3
locus tag: YOR026W
gene synonym: PAC9
product: Bub3p
transcript id: NM_001183445.1
SIO_010081: YOR026W
subclass of: SO_0000673
so part of: YOR026W
location: <379781..>380806
location: region:379781-380806:1
so has part: feature:379781-380806:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:379781-380806:1:exon

YOR026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAC9
gene: BUB3
locus tag: YOR026W
gene synonym: PAC9
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178]
experiment: EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]
experiment: EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]
experiment: EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]
experiment: EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]
note: Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression
codon start: 1
product: Bub3p
translation: MQIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIELNASSIYIIFDYEN
SIO_010081: YOR026W
subclass of: SO_0000673
so part of: YOR026W
location: 379781..380806
location: region:379781-380806:1
so has part: feature:379781-380806:1:exon

NP_014669.1
type: Protein
SIO_000068: ncbiprotein

S000005552
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:379781-380806:1:exon

YOR027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STI1
locus tag: YOR027W
so part of: sequence
location: <381053..>382822
location: region:381053-382822:1
so has part: feature:381053-382822:1:exon
subclass of: SO_0000010

854192
type: Gene
SIO_000068: ncbigene

position:381053:1
position: 381053
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382822:1
position: 382822
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381053-382822:1:exon

YOR027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STI1
locus tag: YOR027W
product: Hsp90 cochaperone STI1
transcript id: NM_001183446.1
SIO_010081: YOR027W
subclass of: SO_0000673
so part of: YOR027W
location: <381053..>382822
location: region:381053-382822:1
so has part: feature:381053-382822:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:381053-382822:1:exon

YOR027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STI1
locus tag: YOR027W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0030544 Hsp70 protein binding [PMID:12716905]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:21170051]
experiment: EXISTENCE:direct assay:GO:0051879 Hsp90 protein binding [PMID:9927435|PMID:12525481]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:8972212]
experiment: EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:27412066]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:24109600]
experiment: EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:12525481]
note: Evolutionarily-conserved Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
codon start: 1
product: Hsp90 cochaperone STI1
translation: MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR
SIO_010081: YOR027W
subclass of: SO_0000673
so part of: YOR027W
location: 381053..382822
location: region:381053-382822:1
so has part: feature:381053-382822:1:exon

NP_014670.1
type: Protein
SIO_000068: ncbiprotein

S000005553
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381053-382822:1:exon

YOR028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HAL6
alternative label: YAP4
gene: CIN5
locus tag: YOR028C
gene synonym: HAL6; YAP4
so part of: sequence
location: complement(<383533..>384420)
location: region:383533-384420:-1
so has part: feature:383533-384420:-1:exon
subclass of: SO_0000010

854193
type: Gene
SIO_000068: ncbigene

position:383533:-1
position: 383533
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384420:-1
position: 384420
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:383533-384420:-1:exon

YOR028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HAL6
alternative label: YAP4
gene: CIN5
locus tag: YOR028C
gene synonym: HAL6; YAP4
product: Cin5p
transcript id: NM_001183447.1
SIO_010081: YOR028C
subclass of: SO_0000673
so part of: YOR028C
location: complement(<383533..>384420)
location: region:383533-384420:-1
so has part: feature:383533-384420:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:383533-384420:-1:exon

YOR028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HAL6
alternative label: YAP4
gene: CIN5
locus tag: YOR028C
gene synonym: HAL6; YAP4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11179441|PMID:19029946]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19029946]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496|PMID:9372930|PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:21552514]
experiment: EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:19774548]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11179441|PMID:15821130|PMID:9593122]
experiment: EXISTENCE:mutant phenotype:GO:0042538 hyperosmotic salinity response [PMID:9559673]
note: Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
codon start: 1
product: Cin5p
translation: MLMQIKMDNHPFNFQPILASHSMTRDSTKPKKMTDTAFVPSPPVGFIKEENKADLHTISVVASNVTLPQIQLPKIATLEEPGYESRTGSLTDLSGRRNSVNIGALCEDVPNTAGPHIARPVTINNLIPPSLPRLNTYQLRPQLSDTHLNCHFNSNPYTTASHAPFESSYTTASTFTSQPAASYFPSNSTPATRKNSATTNLPSEERRRVSVSLSEQVFNEGERYNNDGQLIGKTGKPLRNTKRAAQNRSAQKAFRQRREKYIKNLEEKSKLFDGLMKENSELKKMIESLKSKLKE
SIO_010081: YOR028C
subclass of: SO_0000673
so part of: YOR028C
location: complement(383533..384420)
location: region:383533-384420:-1
so has part: feature:383533-384420:-1:exon

NP_014671.1
type: Protein
SIO_000068: ncbiprotein

S000005554
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:383533-384420:-1:exon

YOR029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR029W
so part of: sequence
location: <384600..>384935
location: region:384600-384935:1
so has part: feature:384600-384935:1:exon
subclass of: SO_0000010

854194
type: Gene
SIO_000068: ncbigene

position:384600:1
position: 384600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384935:1
position: 384935
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:384600-384935:1:exon

YOR029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR029W
product: uncharacterized protein
transcript id: NM_001348877.1
SIO_010081: YOR029W
subclass of: SO_0000673
so part of: YOR029W
location: <384600..>384935
location: region:384600-384935:1
so has part: feature:384600-384935:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:384600-384935:1:exon

YOR029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR029W
note: hypothetical protein; conserved among S. cerevisiae strains; YOR029W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MMQTSTSSRVRRYPYQITLSLVLKGFYSPSAPSYDFCLVLLPTLFLIDLMPIKFSLHVTIGIGEATPVPIFFFSAPWYFRSGNPLPHCVRAYRCKVNFPFFRLGWSTWLHY
SIO_010081: YOR029W
subclass of: SO_0000673
so part of: YOR029W
location: 384600..384935
location: region:384600-384935:1
so has part: feature:384600-384935:1:exon

NP_001335815.1
type: Protein
SIO_000068: ncbiprotein

S000005555
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:384600-384935:1:exon

YOR030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECM41
alternative label: ZRG12
gene: DFG16
locus tag: YOR030W
gene synonym: ECM41; ZRG12
so part of: sequence
location: <386825..>388684
location: region:386825-388684:1
so has part: feature:386825-388684:1:exon
subclass of: SO_0000010

854195
type: Gene
SIO_000068: ncbigene

position:386825:1
position: 386825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388684:1
position: 388684
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:386825-388684:1:exon

YOR030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECM41
alternative label: ZRG12
gene: DFG16
locus tag: YOR030W
gene synonym: ECM41; ZRG12
product: Dfg16p
transcript id: NM_001183449.1
SIO_010081: YOR030W
subclass of: SO_0000673
so part of: YOR030W
location: <386825..>388684
location: region:386825-388684:1
so has part: feature:386825-388684:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:386825-388684:1:exon

YOR030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECM41
alternative label: ZRG12
gene: DFG16
locus tag: YOR030W
gene synonym: ECM41; ZRG12
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:15879523]
note: Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
codon start: 1
product: Dfg16p
translation: MIIRLHFYYLLTLVYHLGLVGAYEKAARKRIQPPDLIPGPPGHKLGDERPPHYDHRPPYKKHIDNIPAYNLTDLIDDKLLNKYENSCTVNVLTGGFISLASNSWHLRAYNYTLNYPSFLIRCDNGSANPNFSHVLQDFVYDINNKFNVQDDSSKYIGKDPFPLGMIMITFASGCICVATWMLFLVVLLLPSDNHNRRNKVVHVYVLFSAIIRTVFLNETIAVIFDSQYHDDYQDASQFESFIVETAPYKICELVANILSDINWIYIVHYLQSNYGKPTWNWIPFKMKKGTHIIITVGCFLSLADNILFANLLWRKNLVVLKVFYKLIELLIYTIFISIICYFTWHNFAYILLPKTAEINTDGKCKTKLRILWENYHETIPLLAYNILIFILFYFTTIFFAAFTKHVRGWTFNFVHLLKVLITVNVWGLIGVLEKRELHISKKTVLGRKINNRDKFFANPTVNYYGEDLGKHLSAITLNRDLNTTKSNTTSHDSSSLVGSPSPTWKSPIERIRDRRRRHKIMKSENKFGQNPSFGSKSNGKPNTKTTLSKYRQLLRKPRRKTNSYEPKNGIGQNKEGSTVRPGADKHIRDSNYLATDISDNESMETELRTNHIYNYENSD
SIO_010081: YOR030W
subclass of: SO_0000673
so part of: YOR030W
location: 386825..388684
location: region:386825-388684:1
so has part: feature:386825-388684:1:exon

NP_014673.1
type: Protein
SIO_000068: ncbiprotein

S000005556
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:386825-388684:1:exon

YOR031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRS5
locus tag: YOR031W
pseudo: true
so part of: sequence
location: 389213..389422
location: region:389213-389422:1
so has part: feature:389213-389422:1:exon

854196
type: Gene
SIO_000068: ncbigene

position:389213:1
position: 389213
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:389422:1
position: 389422
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389213-389422:1:exon

YOR031W
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
gene: CRS5
locus tag: YOR031W
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:17163970]
experiment: EXISTENCE:mutant phenotype:GO:0005507 copper ion binding [PMID:7929222]
experiment: EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:17163970|PMID:7929222]
note: Copper-binding metallothionein; required for wild-type copper resistance
pseudo: true
SIO_010081: YOR031W
subclass of: SO_0000673
so part of: YOR031W
location: 389213..389422
location: region:389213-389422:1
so has part: feature:389213-389422:1:exon

S000005557
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:389213-389422:1:exon

YOR032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HMS1
locus tag: YOR032C
so part of: sequence
location: complement(<389771..>391075)
location: region:389771-391075:-1
so has part: feature:389771-391075:-1:exon
subclass of: SO_0000010

854197
type: Gene
SIO_000068: ncbigene

position:389771:-1
position: 389771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:391075:-1
position: 391075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389771-391075:-1:exon

YOR032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HMS1
locus tag: YOR032C
product: Hms1p
transcript id: NM_001183451.1
SIO_010081: YOR032C
subclass of: SO_0000673
so part of: YOR032C
location: complement(<389771..>391075)
location: region:389771-391075:-1
so has part: feature:389771-391075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:389771-391075:-1:exon

YOR032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HMS1
locus tag: YOR032C
experiment: EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9832522]
note: bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
codon start: 1
product: Hms1p
translation: MPNFQKPFSGSSDGNSVMNDLGNKVAIKVFDCRSAQDGSEEQNVNVTTNQMYLMFQSNNYNVPPPNYNTEDLGSQGPPTHAYYAPFQHPIHLQPPVPPVYKNNTYSATDQYSDSSFPNTSGHTPVIDSNYYNDALASIPTTTTGSTTMTTDNGNTIDSEEYIDNMEVFSSEENENIDNVKQTDLKSEKDSSLLSAASIVKKEQLSGFENFLPLSKTESPLVTADEIKSSLNLENIDNADSMSFKLKTSPIRKHFHVKPKRITRVRTGRVSHNIIEKKYRSNINDKIEQLRRTVPTLRVAYKKCNDLPITSRDLADLDGLEPATKLNKASILTKSIEYICHLERKCLQLSLANQHLSNDTRDSFVHLTEPSQPLSDNSSSEQVQKQTRSCQRQRQRQPRQQQPLHNIQYNIPHQNGLMSGTNNSHDMDFNNAGDF
SIO_010081: YOR032C
subclass of: SO_0000673
so part of: YOR032C
location: complement(389771..391075)
location: region:389771-391075:-1
so has part: feature:389771-391075:-1:exon

NP_014675.1
type: Protein
SIO_000068: ncbiprotein

S000005558
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:389771-391075:-1:exon

YOR032W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR032W-A
so part of: sequence
location: <392176..>392376
location: region:392176-392376:1
so has part: feature:392176-392376:1:exon
subclass of: SO_0000010

1466481
type: Gene
SIO_000068: ncbigene

position:392176:1
position: 392176
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:392376:1
position: 392376
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392176-392376:1:exon

YOR032W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR032W-A
product: uncharacterized protein
transcript id: NM_001184624.1
SIO_010081: YOR032W-A
subclass of: SO_0000673
so part of: YOR032W-A
location: <392176..>392376
location: region:392176-392376:1
so has part: feature:392176-392376:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392176-392376:1:exon

YOR032W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR032W-A
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MRRALFIAGQTYLWLNLTHLLLIFSWSSTMAFSQSRRLLTPTVPCPTLLGIDFLILVLRHFDEIFI
SIO_010081: YOR032W-A
subclass of: SO_0000673
so part of: YOR032W-A
location: 392176..392376
location: region:392176-392376:1
so has part: feature:392176-392376:1:exon

NP_878169.1
type: Protein
SIO_000068: ncbiprotein

S000028710
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392176-392376:1:exon

YOR033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DHS1
gene: EXO1
locus tag: YOR033C
gene synonym: DHS1
so part of: sequence
location: complement(<392416..>394524)
location: region:392416-394524:-1
so has part: feature:392416-394524:-1:exon
subclass of: SO_0000010

854198
type: Gene
SIO_000068: ncbigene

position:392416:-1
position: 392416
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394524:-1
position: 394524
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392416-394524:-1:exon

YOR033C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DHS1
gene: EXO1
locus tag: YOR033C
gene synonym: DHS1
product: Rad2 family nuclease EXO1
transcript id: NM_001183452.1
SIO_010081: YOR033C
subclass of: SO_0000673
so part of: YOR033C
location: complement(<392416..>394524)
location: region:392416-394524:-1
so has part: feature:392416-394524:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392416-394524:-1:exon

YOR033C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DHS1
gene: EXO1
locus tag: YOR033C
gene synonym: DHS1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:12531018]
experiment: EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:12531018]
experiment: EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]
experiment: EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:15126387|PMID:19595717]
experiment: EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:17347674|PMID:21841787|PMID:18805091]
experiment: EXISTENCE:genetic interaction:GO:0031860 telomeric 3' overhang formation [PMID:20808892]
experiment: EXISTENCE:genetic interaction:GO:0044818 mitotic G2/M transition checkpoint [PMID:18805091]
experiment: EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:17347674]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:11438669]
experiment: EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:18806779]
note: 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication
codon start: 1
product: Rad2 family nuclease EXO1
translation: MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHRAACSCAYELAMGKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKLPKKFPLGSLTNEEIITMVCLSGCDYTNGIPKVGLITAMKLVRRFNTIERIILSIQREGKLMIPDTYINEYEAAVLAFQFQRVFCPIRKKIVSLNEIPLYLKDTESKRKRLYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIAQGDLNPYDFHQPLANREHKLQLASKSNIEFGKTNTTNSEAKVKPIESFFQKMTKLDHNPKVANNIHSLRQAEDKLTMAIKRRKLSNANVVQETLKDTRSKFFNKPSMTVVENFKEKGDSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLSEEVSEVVSDIEEDRKNSEGKTIGNEIYNTDDDGDGDTSEDYSETAESRVPTSSTTSFPGSSQRSISGCTKVLQKFRYSSSFSGVNANRQPLFPRHVNQKSRGMVYVNQNRDDDCDDNDGKNQITQRPSLRKSLIGARSQRIVIDMKSVDERKSFNSSPILHEESKKRDIETTKSSQARPAVRSISLLSQFVYKGK
SIO_010081: YOR033C
subclass of: SO_0000673
so part of: YOR033C
location: complement(392416..394524)
location: region:392416-394524:-1
so has part: feature:392416-394524:-1:exon

NP_014676.1
type: Protein
SIO_000068: ncbiprotein

S000005559
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392416-394524:-1:exon

YOR034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AKR2
locus tag: YOR034C
so part of: sequence
location: complement(<394837..>397086)
location: region:394837-397086:-1
so has part: feature:394837-397086:-1:exon
subclass of: SO_0000010

854199
type: Gene
SIO_000068: ncbigene

position:394837:-1
position: 394837
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397086:-1
position: 397086
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394837-397086:-1:exon

YOR034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AKR2
locus tag: YOR034C
product: putative palmitoyltransferase AKR2
transcript id: NM_001183453.1
SIO_010081: YOR034C
subclass of: SO_0000673
so part of: YOR034C
location: complement(<394837..>397086)
location: region:394837-397086:-1
so has part: feature:394837-397086:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394837-397086:-1:exon

YOR034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AKR2
locus tag: YOR034C
EC number: 2.3.1.225
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16647879]
note: Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication
codon start: 1
product: putative palmitoyltransferase AKR2
translation: MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSPFLLMVYIYLISLVLSPVLAIMLSLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAMLIVQFFQILKGITTPELFILIKEEHKAKFINLIPFENSIYTSESKGVEDSDMIPEGPSATTITHTISIDGLEPRNRRRAILSACFSMMGINQWLVTIKEIVGITHILHGQVPQQHHSSLLRSFLVTNHWKTNLTDFWLNSDVTAPLWQRFFYSSDTSKAMLGGTEVDYYELYEYPAREGEVLRPN
SIO_010081: YOR034C
subclass of: SO_0000673
so part of: YOR034C
location: complement(394837..397086)
location: region:394837-397086:-1
so has part: feature:394837-397086:-1:exon

NP_014677.1
type: Protein
SIO_000068: ncbiprotein

S000005560
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394837-397086:-1:exon

YOR034C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR034C-A
so part of: sequence
location: complement(<397426..>397668)
location: region:397426-397668:-1
so has part: feature:397426-397668:-1:exon
subclass of: SO_0000010

1466482
type: Gene
SIO_000068: ncbigene

position:397426:-1
position: 397426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397668:-1
position: 397668
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397426-397668:-1:exon

YOR034C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR034C-A
product: uncharacterized protein
transcript id: NM_001184667.1
SIO_010081: YOR034C-A
subclass of: SO_0000673
so part of: YOR034C-A
location: complement(<397426..>397668)
location: region:397426-397668:-1
so has part: feature:397426-397668:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397426-397668:-1:exon

YOR034C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR034C-A
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MNTQELCKIFVAREYPLVVVPFIYFVLFLHQKYHTTLNYVWYPTCSKRIWVREKGRKCSFFFFSKVPRSDGFANNRCQRK
SIO_010081: YOR034C-A
subclass of: SO_0000673
so part of: YOR034C-A
location: complement(397426..397668)
location: region:397426-397668:-1
so has part: feature:397426-397668:-1:exon

NP_878170.1
type: Protein
SIO_000068: ncbiprotein

S000028856
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397426-397668:-1:exon

YOR035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DIM1
gene: SHE4
locus tag: YOR035C
gene synonym: DIM1
so part of: sequence
location: complement(<397735..>400104)
location: region:397735-400104:-1
so has part: feature:397735-400104:-1:exon
subclass of: SO_0000010

854200
type: Gene
SIO_000068: ncbigene

position:397735:-1
position: 397735
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400104:-1
position: 400104
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397735-400104:-1:exon

YOR035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DIM1
gene: SHE4
locus tag: YOR035C
gene synonym: DIM1
product: She4p
transcript id: NM_001183454.1
SIO_010081: YOR035C
subclass of: SO_0000673
so part of: YOR035C
location: complement(<397735..>400104)
location: region:397735-400104:-1
so has part: feature:397735-400104:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397735-400104:-1:exon

YOR035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DIM1
gene: SHE4
locus tag: YOR035C
gene synonym: DIM1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8625407]
experiment: EXISTENCE:direct assay:GO:0017022 myosin binding [PMID:12725728]
experiment: EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:11553699]
note: Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
codon start: 1
product: She4p
translation: MPLCEKGNDPIDSSTIDSLCAAFDKTLKSTPDVQKYNDAINTIFQLRQKSESGKMPADLTNSEALKDRQKIEEILTRSYQDHSESRVHLSKLIQNDIPFALNLFEILSRSSIHVFVGCFSNKDATIALLNELQIRIHYGEDTHVTYLLSIILQLLNKFKYNFKEVRFLVKELILRISEDEVKSMMLIIFAELQSSFQKDFDKAVVDFMSSLIVEAEIDVGNDPLSIIVKTLSELYPSLTTLCSEIFLTKGLSKLFKKRVFEEQDLQFTKELLRLLSSACIDETMRTYITENYLQLLERSLNVEDVQIYSALVLVKTWSFTKLTCINLKQLSEIFINAISRRIMPKIENVNESAVKLEEVPKVEMSVEALAYLSLKASVKIMIRSNESFTEILLTMIKSQKMTHCLYGLLVIMANLSTLPEESNGSSQSINDLKNYADLKGPGADKVGAEKESKEDILLFNEKYILRTELISFLKREMHNLSPNCKQQVVRVIYNITRSKNFIPQCISQGGTTIILEYLANKQDIGEPIRILGCRALTRMLIFTNPGLIFKKYSALNAIPFLFELLPRSTPVDDNPLHNDEQIKLTDNYEALLALTNLASSETSDGEEVCKHIVSTKVYWSTIENLMLDENVPLQRSTLELISNMMSHPLTIAAKFFNLENPQSLRNFNILVKLLQLSDVESQRAVAAIFANIATTIPLIAKELLTKKELIENAIQVFADQIDDIELRQRLLMLFFGLFEVIPDNGTNEVYPLLQENQKLKDALNMSLKRGDSGPEFSAAIPVILAKIKV
SIO_010081: YOR035C
subclass of: SO_0000673
so part of: YOR035C
location: complement(397735..400104)
location: region:397735-400104:-1
so has part: feature:397735-400104:-1:exon

NP_014678.1
type: Protein
SIO_000068: ncbiprotein

S000005561
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397735-400104:-1:exon

YOR036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VPL6
alternative label: VPS6
alternative label: VPT13
gene: PEP12
locus tag: YOR036W
gene synonym: VPL6; VPS6; VPT13
so part of: sequence
location: <400348..>401214
location: region:400348-401214:1
so has part: feature:400348-401214:1:exon
subclass of: SO_0000010

854201
type: Gene
SIO_000068: ncbigene

position:400348:1
position: 400348
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:401214:1
position: 401214
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:400348-401214:1:exon

YOR036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VPL6
alternative label: VPS6
alternative label: VPT13
gene: PEP12
locus tag: YOR036W
gene synonym: VPL6; VPS6; VPT13
product: SNAP receptor PEP12
transcript id: NM_001183455.1
SIO_010081: YOR036W
subclass of: SO_0000673
so part of: YOR036W
location: <400348..>401214
location: region:400348-401214:1
so has part: feature:400348-401214:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:400348-401214:1:exon

YOR036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VPL6
alternative label: VPS6
alternative label: VPT13
gene: PEP12
locus tag: YOR036W
gene synonym: VPL6; VPS6; VPT13
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:14981247]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]
experiment: EXISTENCE:mutant phenotype:GO:0005484 SNAP receptor activity [PMID:8730101]
experiment: EXISTENCE:mutant phenotype:GO:0005768 endosome [PMID:8730101]
experiment: EXISTENCE:mutant phenotype:GO:0005794 Golgi apparatus [PMID:8730101]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:8730101]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:19793921]
note: Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
codon start: 1
product: SNAP receptor PEP12
translation: MSEDEFFGGDNEAVWNGSRFSDSPEFQTLKEEVAAELFEINGQISTLQQFTATLKSFIDRGDVSAKVVERINKRSVAKIEEIGGLIKKVNTSVKKMDAIEEASLDKTQIIAREKLVRDVSYSFQEFQGIQRQFTQVMKQVNERAKESLEASEMANDAALLDEEQRQNSSKSTRIPGSQIVIERDPINNEEFAYQQNLIEQRDQEISNIERGITELNEVFKDLGSVVQQQGVLVDNIEANIYTTSDNTQLASDELRKAMRYQKRTSRWRVYLLIVLLVMLLFIFLIMKL
SIO_010081: YOR036W
subclass of: SO_0000673
so part of: YOR036W
location: 400348..401214
location: region:400348-401214:1
so has part: feature:400348-401214:1:exon

NP_014679.1
type: Protein
SIO_000068: ncbiprotein

S000005562
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:400348-401214:1:exon

YOR037W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CYC2
locus tag: YOR037W
so part of: sequence
location: <401555..>402655
location: region:401555-402655:1
so has part: feature:401555-402655:1:exon
subclass of: SO_0000010

854202
type: Gene
SIO_000068: ncbigene

position:401555:1
position: 401555
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402655:1
position: 402655
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401555-402655:1:exon

YOR037W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CYC2
locus tag: YOR037W
product: oxidoreductase
transcript id: NM_001183456.1
SIO_010081: YOR037W
subclass of: SO_0000673
so part of: YOR037W
location: <401555..>402655
location: region:401555-402655:1
so has part: feature:401555-402655:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:401555-402655:1:exon

YOR037W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CYC2
locus tag: YOR037W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16207709]
experiment: EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:16207709]
experiment: EXISTENCE:genetic interaction:GO:0018063 cytochrome c-heme linkage [PMID:14514677|PMID:16207709]
experiment: EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:11488609]
note: Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
codon start: 1
product: oxidoreductase
translation: MLWKNYVLSSSRITRRLHKSPRKSSFSKNFFITGCLLTVGAVSSYLTYRYTSERENKHELSPSYFVKYKISHKRDIDSSHFLLEVTPLFKQKVNIWSLMTAENLWSVEIKQPEVMVVRNYTPLPLKFNPASKEIEILKDGDNADGKLSFYIKKYENGEVARWLHHLPKGHIIEIRGPFIDYEFPHLPNELKRSRDCLYMDNRNERGNNVRENSQFIYQPYDIMMFTAGTGIVTALQLLLTESPFRGTIKLFHTDKNIKQLGPLYPILLRLQASNRVQLKIFETDRQTKQDVLKSIQKSITKPYPYKGLLPFSNVNNKNIMPVLALVCGPESYISSISGRKYDLNQGPVGGLLSKEGWNSDNVYKLS
SIO_010081: YOR037W
subclass of: SO_0000673
so part of: YOR037W
location: 401555..402655
location: region:401555-402655:1
so has part: feature:401555-402655:1:exon

NP_014680.2
type: Protein
SIO_000068: ncbiprotein

S000005563
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401555-402655:1:exon

YOR038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPT1
gene: HIR2
locus tag: YOR038C
gene synonym: SPT1
so part of: sequence
location: complement(<402761..>405388)
location: region:402761-405388:-1
so has part: feature:402761-405388:-1:exon
subclass of: SO_0000010

854203
type: Gene
SIO_000068: ncbigene

position:402761:-1
position: 402761
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:405388:-1
position: 405388
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402761-405388:-1:exon

YOR038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPT1
gene: HIR2
locus tag: YOR038C
gene synonym: SPT1
product: Hir2p
transcript id: NM_001183457.1
SIO_010081: YOR038C
subclass of: SO_0000673
so part of: YOR038C
location: complement(<402761..>405388)
location: region:402761-405388:-1
so has part: feature:402761-405388:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402761-405388:-1:exon

YOR038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPT1
gene: HIR2
locus tag: YOR038C
gene synonym: SPT1
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9001207]
experiment: EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16264190|PMID:16303565]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]
experiment: EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9001207]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8417331|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16264190|PMID:16303565]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:16449659]
experiment: EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]
experiment: EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]
experiment: EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]
experiment: EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]
note: Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Hir2p
translation: MRLLKYPLDIHNEQVNALAALGPYIILAGSGGHVMAWRQQQLVDTAFDRVMIKDLKPEVSFQVDQDTTGDIFFITGDLETLYIGSEHRLWGYSGWLCRDTNNINSVEKMNSKLLFECKSPSTITDVKYDINLGILFVLLSNENKILLFRHKTFDKLSEITIDKASKPITGIIDPTGQTFTVMTSDRSILVYQINKTGTHKLINKLTQHVQMYPLHYRISMSPQADILPVINSVKGVPNNATSCTALLDRNNNYKVTKTLVTPSSNGCRVLVYSPAFYEKPNLKKGTSTRYNLIATSGSTDGTILVWNTKRMKPLFNALQVSSTAINDMSWSQDGFTLFAISNDATLYTFAFQEKDLGVALPQTEIKSLQEVNKKLPKLEEPLAEQIPKSFPENIKLEESASAAPIPNDIGRSAVGKKPTKKKTANNQTNGIKTIQSTSMEFNTPSYTVPRDLKRKPKEATPSNIAPGSKKQKKELQPIDFLDTGLLLPNTSFSRIRLATPKIRSTFKYSPINNPNLILDVKNGSGNEQRPTIVKLTSKVLDQDQVLFQDFIPKLITICTAGDTFWSFCSEDGSIYIYSDSGRKLMAPLVLGVSISFLEACGTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDILTRAENITLCSITKKGVPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSKANTDSFNGSESNINEIVSDIKNDNQSIINFLECKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSHLENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDVFQWLYDDLPISGTGSAFADKDFKRNLLKKILIACGDIRQVQRVTTRYAKEMNIIS
SIO_010081: YOR038C
subclass of: SO_0000673
so part of: YOR038C
location: complement(402761..405388)
location: region:402761-405388:-1
so has part: feature:402761-405388:-1:exon

NP_014681.1
type: Protein
SIO_000068: ncbiprotein

S000005564
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402761-405388:-1:exon

YOR039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CKB2
locus tag: YOR039W
so part of: sequence
location: <405768..>406544
location: region:405768-406544:1
so has part: feature:405768-406544:1:exon
subclass of: SO_0000010

854204
type: Gene
SIO_000068: ncbigene

position:405768:1
position: 405768
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:406544:1
position: 406544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405768-406544:1:exon

YOR039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CKB2
locus tag: YOR039W
product: casein kinase 2 regulatory subunit CKB2
transcript id: NM_001183458.1
SIO_010081: YOR039W
subclass of: SO_0000673
so part of: YOR039W
location: <405768..>406544
location: region:405768-406544:1
so has part: feature:405768-406544:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:405768-406544:1:exon

YOR039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CKB2
locus tag: YOR039W
experiment: EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]
experiment: EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006974 cellular response to DNA damage stimulus [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:18265947]
experiment: EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]
experiment: EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]
experiment: EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11827175]
note: Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
codon start: 1
product: casein kinase 2 regulatory subunit CKB2
translation: MGSRSENVGTVTREGSRVEQDDVLMDDDSDSSEYVDMWIDLFLGRKGHEYFCDVDPEYITDRFNLMNLQKTVSKFSYVVQYIVDDLDDSILENMTHARLEQLESDSRKLYGLIHARYIITIKGLQKMYAKYKEADFGRCPRVYCNLQQLLPVGLHDIPGIDCVKLYCPSCEDLYIPKSSRHSSIDGAYFGTSFPGMFLQAFPDMVPKHPTKRYVPKIFGFELHKQAQLTRWQELQRLKLVEKLESKDVDLTKSGGFKT
SIO_010081: YOR039W
subclass of: SO_0000673
so part of: YOR039W
location: 405768..406544
location: region:405768-406544:1
so has part: feature:405768-406544:1:exon

NP_014682.1
type: Protein
SIO_000068: ncbiprotein

S000005565
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:405768-406544:1:exon

YOR040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLO4
locus tag: YOR040W
so part of: sequence
location: <407064..>407921
location: region:407064-407921:1
so has part: feature:407064-407921:1:exon
subclass of: SO_0000010

854205
type: Gene
SIO_000068: ncbigene

position:407064:1
position: 407064
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:407921:1
position: 407921
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407064-407921:1:exon

YOR040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLO4
locus tag: YOR040W
product: hydroxyacylglutathione hydrolase GLO4
transcript id: NM_001183459.1
SIO_010081: YOR040W
subclass of: SO_0000673
so part of: YOR040W
location: <407064..>407921
location: region:407064-407921:1
so has part: feature:407064-407921:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407064-407921:1:exon

YOR040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLO4
locus tag: YOR040W
EC number: 3.1.2.6
experiment: EXISTENCE:direct assay:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9261170]
experiment: EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]
experiment: EXISTENCE:genetic interaction:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]
experiment: EXISTENCE:genetic interaction:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]
experiment: EXISTENCE:mutant phenotype:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]
experiment: EXISTENCE:mutant phenotype:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]
note: Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication
codon start: 1
product: hydroxyacylglutathione hydrolase GLO4
translation: MKFLLQQIRNMHVKPIKMRWLTGGVNYSYLLSTEDRRNSWLIDPAEPLEVSPKLSAEEKKSIDAIVNTHHHYDHSGGNLALYSILCQENSGHDIKIIGGSKSSPGVTEVPDNLQQYHLGNLRVTCIRTPCHTKDSICYYIKDLETGEQCIFTGDTLFIAGCGRFFEGTGRDMDMALNQIMLRAVGETNWNKVKIYPGHEYTKGNVSFIRAKIYSDIGQNKEFDALEQYCKSNECTTGHFTLRDELGYNPFMRLDDRAVRLAVGDTAGTYPRSVVMQELRKLKNAM
SIO_010081: YOR040W
subclass of: SO_0000673
so part of: YOR040W
location: 407064..407921
location: region:407064-407921:1
so has part: feature:407064-407921:1:exon

NP_014683.1
type: Protein
SIO_000068: ncbiprotein

S000005566
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407064-407921:1:exon

YNCO0014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR9
locus tag: YNCO0014C
so part of: sequence
location: complement(407948..408134)
location: region:407948-408134:-1
so has part: feature:407948-408134:-1:exon
subclass of: SO_0000578

9164974
type: Gene
SIO_000068: ncbigene

position:407948:-1
position: 407948
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:408134:-1
position: 408134
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407948-408134:-1:exon

YNCO0014C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR9
locus tag: YNCO0014C
product: SNR9
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:3327689]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:3327689]
experiment: EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:3327689]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2340 and U2345
transcript id: NR_132258.1
SIO_010081: YNCO0014C
subclass of: SO_0000673
so part of: YNCO0014C
location: complement(407948..408134)
location: region:407948-408134:-1
so has part: feature:407948-408134:-1:exon

S000007292
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407948-408134:-1:exon

YOR042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUE5
locus tag: YOR042W
so part of: sequence
location: <408425..>409660
location: region:408425-409660:1
so has part: feature:408425-409660:1:exon
subclass of: SO_0000010

854206
type: Gene
SIO_000068: ncbigene

position:408425:1
position: 408425
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:409660:1
position: 409660
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408425-409660:1:exon

YOR042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUE5
locus tag: YOR042W
product: ubiquitin-binding protein CUE5
transcript id: NM_001183461.1
SIO_010081: YOR042W
subclass of: SO_0000673
so part of: YOR042W
location: <408425..>409660
location: region:408425-409660:1
so has part: feature:408425-409660:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:408425-409660:1:exon

YOR042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUE5
locus tag: YOR042W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]
experiment: EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25042851]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:25042851]
note: Ubiquitin-binding protein; functions as a Ub-Atg8p adaptor in ubiquitin-dependent autophagy; serves as a proteaphagy receptor for inactivated 26S proteasomes; contains a CUE domain that binds K48-and K63-linked Ub chains and also binds monoubiquitin, facilitating intramolecular monoubiquitination; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q
codon start: 1
product: ubiquitin-binding protein CUE5
translation: MEEKEGIKDSSLLEKSNVPESINEDISKTTDVDLNSDGKKDNDTSAKDGTPKVEEKVNKSSGIDEDEVVTPAEDAKEEEEEHPPLPARRKSEEEPSKENPILQELKDAFPNLEEKYIKAVIIASQGVLSPAFNALLFLSDPESGKDIELPTQPVRKNPEAPARRRQTQLEQDELLARQLDEQFNSSHSRRRNRDRATRSMHEQRRRRHNPNEREQHHEDSEEEDSWSQFVEKDLPELTDRAGRSLQDTANKVSNWISDAYRRNFASGNEQNDNQHGHQDQQEWEPEIVDLSQGGKNSRPQQPERRRFNSFGVQVGDDSLESHGITLHNEDGFEDDEDVPPQLPTRTKSGESTGKVVAETTYIDTPDTETKKKWQPLPPEPLDTTPTKVNAVSRNKKNPDEDEFLINSDDEM
SIO_010081: YOR042W
subclass of: SO_0000673
so part of: YOR042W
location: 408425..409660
location: region:408425-409660:1
so has part: feature:408425-409660:1:exon

NP_014685.1
type: Protein
SIO_000068: ncbiprotein

S000005568
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:408425-409660:1:exon

YNCO0015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR62
locus tag: YNCO0015C
so part of: sequence
location: complement(409765..409864)
location: region:409765-409864:-1
so has part: feature:409765-409864:-1:exon
subclass of: SO_0000578

9164978
type: Gene
SIO_000068: ncbigene

position:409765:-1
position: 409765
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:409864:-1
position: 409864
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:409765-409864:-1:exon

YNCO0015C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR62
locus tag: YNCO0015C
product: SNR62
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U1888
transcript id: NR_132259.1
SIO_010081: YNCO0015C
subclass of: SO_0000673
so part of: YNCO0015C
location: complement(409765..409864)
location: region:409765-409864:-1
so has part: feature:409765-409864:-1:exon

S000006453
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:409765-409864:-1:exon

YOR043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WHI2
locus tag: YOR043W
so part of: sequence
location: <410870..>412330
location: region:410870-412330:1
so has part: feature:410870-412330:1:exon
subclass of: SO_0000010

854208
type: Gene
SIO_000068: ncbigene

position:410870:1
position: 410870
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412330:1
position: 412330
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410870-412330:1:exon

YOR043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WHI2
locus tag: YOR043W
product: Whi2p
transcript id: NM_001183462.1
SIO_010081: YOR043W
subclass of: SO_0000673
so part of: YOR043W
location: <410870..>412330
location: region:410870-412330:1
so has part: feature:410870-412330:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410870-412330:1:exon

YOR043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WHI2
locus tag: YOR043W
experiment: EXISTENCE:direct assay:GO:0019903 protein phosphatase binding [PMID:12090248]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:21429936]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15020461]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:15020461]
experiment: EXISTENCE:mutant phenotype:GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress [PMID:12090248]
experiment: EXISTENCE:mutant phenotype:GO:1903452 positive regulation of G1 to G0 transition [PMID:7001255]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]
note: Negative regulator of TORC1 in response to limiting leucine; suppresses TORC1 activity with binding partners Psr1p/Psr2p, acting in parallel with SEACIT; regulates cell cycle arrest in stationary phase; inhibits Ras-cAMP-PKA regulation of apoptosis during nutrient depletion; required with Psr1p for activation of the general stress response; role in rapamycin-induced mitophagy; localizes to the cell periphery; human tumor suppressor and Whi2-like protein KCTD11 functionally complements the null
codon start: 1
product: Whi2p
translation: MDDIITQVSPDNAESAPILQEQQQQQNSQYEGNEEDYGDSLIHLNIQENHYFITRDQLMSLPESLLLCLFPSGVFLDRCGQVITNLTRDDEVYIVNFPPDCFEYIMEIYTKAHDDLYNHPVEKFFDRPSSSFVSNAKGFFGLSSNNSISSNNEQDILHQKPAIIVLREDLDYYCVPQEEFQFDSTNEENNEDLLRHFMAQVKMAAGSYLTSKTSIFQGLYSSNRLKQQQQQQKIEKGSNSSSNTKSTSKKLGPAEQHLMDMLCSSGFTKETCWGNRTQETGKTVISSLSLCRLANETTEGFRQKFNEAKAKWEAEHKPSQDNFITPMQSNISINSLSASKSNSTISTARNLTSGSTAPATARDKRKSRLSKLADNVRSHSSSRHSSQTRSKPPELPKLYDLVPKPNINAKLLLFWRKPARKCWWGEEDIELEVEVFGSWKDESKKIIELILPTNVDPEAELHKIIVPVRLHIRRVWTLELSVIGVQ
SIO_010081: YOR043W
subclass of: SO_0000673
so part of: YOR043W
location: 410870..412330
location: region:410870-412330:1
so has part: feature:410870-412330:1:exon

NP_014686.1
type: Protein
SIO_000068: ncbiprotein

S000005569
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410870-412330:1:exon

YOR044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRC23
locus tag: YOR044W
so part of: sequence
location: <413007..>413480
location: region:413007-413480:1
so has part: feature:413007-413480:1:exon
subclass of: SO_0000010

854209
type: Gene
SIO_000068: ncbigene

position:413007:1
position: 413007
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:413480:1
position: 413480
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413007-413480:1:exon

YOR044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRC23
locus tag: YOR044W
product: Irc23p
transcript id: NM_001183463.1
SIO_010081: YOR044W
subclass of: SO_0000673
so part of: YOR044W
location: <413007..>413480
location: region:413007-413480:1
so has part: feature:413007-413480:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413007-413480:1:exon

YOR044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRC23
locus tag: YOR044W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
note: hypothetical protein involved in multidrug resistance; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
codon start: 1
product: Irc23p
translation: MIEALEIVLLLVIQSLQYICRTCIAFLLIPFLGLYAFDLFLYVYRMILYLSQMFNYKRKLGRSKTNNRPHSPRLHKIYSSGDCMDTLIGQVRDLRVFLLSTIHSHSKRFFSTRFQTKSGINSAIDANDVETTSDVSSFTNLHLTRSSEEGYYIAGSI
SIO_010081: YOR044W
subclass of: SO_0000673
so part of: YOR044W
location: 413007..413480
location: region:413007-413480:1
so has part: feature:413007-413480:1:exon

NP_014687.1
type: Protein
SIO_000068: ncbiprotein

S000005570
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413007-413480:1:exon

YOR045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISP6
alternative label: MOM8B
gene: TOM6
locus tag: YOR045W
gene synonym: ISP6; MOM8B
so part of: sequence
location: <413852..>414037
location: region:413852-414037:1
so has part: feature:413852-414037:1:exon
subclass of: SO_0000010

854210
type: Gene
SIO_000068: ncbigene

position:413852:1
position: 413852
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:414037:1
position: 414037
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413852-414037:1:exon

YOR045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISP6
alternative label: MOM8B
gene: TOM6
locus tag: YOR045W
gene synonym: ISP6; MOM8B
product: Tom6p
transcript id: NM_001183464.1
SIO_010081: YOR045W
subclass of: SO_0000673
so part of: YOR045W
location: <413852..>414037
location: region:413852-414037:1
so has part: feature:413852-414037:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413852-414037:1:exon

YOR045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISP6
alternative label: MOM8B
gene: TOM6
locus tag: YOR045W
gene synonym: ISP6; MOM8B
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:7565772]
experiment: EXISTENCE:direct assay:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:20668160]
experiment: EXISTENCE:mutant phenotype:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667|PMID:7565772]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:9774667]
note: Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
codon start: 1
product: Tom6p
translation: MDGMFAMPGAAAGAASPQQPKSRFQAFKESPLYTIALNGAFFVAGVAFIQSPLMDMLAPQL
SIO_010081: YOR045W
subclass of: SO_0000673
so part of: YOR045W
location: 413852..414037
location: region:413852-414037:1
so has part: feature:413852-414037:1:exon

NP_014688.1
type: Protein
SIO_000068: ncbiprotein

S000005571
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413852-414037:1:exon

YOR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RAT8
gene: DBP5
locus tag: YOR046C
gene synonym: RAT8
so part of: sequence
location: complement(<414459..>415907)
location: region:414459-415907:-1
so has part: feature:414459-415907:-1:exon
subclass of: SO_0000010

854211
type: Gene
SIO_000068: ncbigene

position:414459:-1
position: 414459
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:415907:-1
position: 415907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:414459-415907:-1:exon

YOR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RAT8
gene: DBP5
locus tag: YOR046C
gene synonym: RAT8
product: ATP-dependent RNA helicase DBP5
transcript id: NM_001183465.1
SIO_010081: YOR046C
subclass of: SO_0000673
so part of: YOR046C
location: complement(<414459..>415907)
location: region:414459-415907:-1
so has part: feature:414459-415907:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:414459-415907:-1:exon

YOR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RAT8
gene: DBP5
locus tag: YOR046C
gene synonym: RAT8
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:16783363]
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:9564047]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15280434]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10610322|PMID:15280434|PMID:9564048]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:17272721]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:19198597]
experiment: EXISTENCE:direct assay:GO:0006409 tRNA export from nucleus [PMID:31453808]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:19805289]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:27251550]
experiment: EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:10610322]
experiment: EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:17272721]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:9564048]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]
experiment: EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:17272721]
note: Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress
codon start: 1
product: ATP-dependent RNA helicase DBP5
translation: MSDTKRDPADLLASLKIDNEKEDTSEVSTKETVKSQPEKTADSIKPAEKLVPKVEEKKTKQEDSNLISSEYEVKVKLADIQADPNSPLYSAKSFDELGLAPELLKGIYAMKFQKPSKIQERALPLLLHNPPRNMIAQSQSGTGKTAAFSLTMLTRVNPEDASPQAICLAPSRELARQTLEVVQEMGKFTKITSQLIVPDSFEKNKQINAQVIVGTPGTVLDLMRRKLMQLQKIKIFVLDEADNMLDQQGLGDQCIRVKRFLPKDTQLVLFSATFADAVRQYAKKIVPNANTLELQTNEVNVDAIKQLYMDCKNEADKFDVLTELYGLMTIGSSIIFVATKKTANVLYGKLKSEGHEVSILHGDLQTQERDRLIDDFREGRSKVLITTNVLARGIDIPTVSMVVNYDLPTLANGQADPATYIHRIGRTGRFGRKGVAISFVHDKNSFNILSAIQKYFGDIEMTRVPTDDWDEVEKIVKKVLKD
SIO_010081: YOR046C
subclass of: SO_0000673
so part of: YOR046C
location: complement(414459..415907)
location: region:414459-415907:-1
so has part: feature:414459-415907:-1:exon

NP_014689.1
type: Protein
SIO_000068: ncbiprotein

S000005572
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:414459-415907:-1:exon

YOR047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MSN3
alternative label: SFS3
gene: STD1
locus tag: YOR047C
gene synonym: MSN3; SFS3
so part of: sequence
location: complement(<416347..>417681)
location: region:416347-417681:-1
so has part: feature:416347-417681:-1:exon
subclass of: SO_0000010

854212
type: Gene
SIO_000068: ncbigene

position:416347:-1
position: 416347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:417681:-1
position: 417681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:416347-417681:-1:exon

YOR047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MSN3
alternative label: SFS3
gene: STD1
locus tag: YOR047C
gene synonym: MSN3; SFS3
product: Std1p
transcript id: NM_001183466.1
SIO_010081: YOR047C
subclass of: SO_0000673
so part of: YOR047C
location: complement(<416347..>417681)
location: region:416347-417681:-1
so has part: feature:416347-417681:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:416347-417681:-1:exon

YOR047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MSN3
alternative label: SFS3
gene: STD1
locus tag: YOR047C
gene synonym: MSN3; SFS3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10373505]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10373505]
experiment: EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:12618390]
experiment: EXISTENCE:genetic interaction:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:genetic interaction:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:10373505]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:7667094]
experiment: EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:10373505]
experiment: EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9725828]
experiment: EXISTENCE:mutant phenotype:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:mutant phenotype:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]
note: Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication
codon start: 1
product: Std1p
translation: MFVSPPPATARNQVLGKRKSKRHDENPKNVQPNADTEMTNSVPSIGFNSNLPHNNQEINTPNHYNLSSNSGNVRSNNNFVTTPPEYADRARIEIIKRLLPTAGTKPMEVNSNTAENANIQHINTPDSQSFVSDHSSSYESSIFSQPSTALTDITTGSSLIDTKTPKFVTEVTLEDALPKTFYDMYSPEVLMSDPANILYNGRPKFTKRELLDWDLNDIRSLLIVEQLRPEWGSQLPTVVTSGINLPQFRLQLLPLSSSDEFIIATLVNSDLYIEANLDRNFKLTSAKYTVASARKRHEEMTGSKEPIMRLSKPEWRNIIENYLLNVAVEAQCRYDFKQKRSEYKRWKLLNSNLKRPDMPPPSLIPHGFKIHDCTNSGSLLKKALMKNLQLKNYKNDAKTLGAGTQKNVVNKVSLTSEERAAIWFQCQTQVYQRLGLDWKPDGMS
SIO_010081: YOR047C
subclass of: SO_0000673
so part of: YOR047C
location: complement(416347..417681)
location: region:416347-417681:-1
so has part: feature:416347-417681:-1:exon

NP_014690.1
type: Protein
SIO_000068: ncbiprotein

S000005573
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:416347-417681:-1:exon

YOR048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HKE1
alternative label: TAP1
alternative label: XRN2
gene: RAT1
locus tag: YOR048C
gene synonym: HKE1; TAP1; XRN2
so part of: sequence
location: complement(<418630..>421650)
location: region:418630-421650:-1
so has part: feature:418630-421650:-1:exon
subclass of: SO_0000010

854213
type: Gene
SIO_000068: ncbigene

position:418630:-1
position: 418630
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:421650:-1
position: 421650
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:418630-421650:-1:exon

YOR048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HKE1
alternative label: TAP1
alternative label: XRN2
gene: RAT1
locus tag: YOR048C
gene synonym: HKE1; TAP1; XRN2
product: ssRNA exonuclease RAT1
transcript id: NM_001183467.1
SIO_010081: YOR048C
subclass of: SO_0000673
so part of: YOR048C
location: complement(<418630..>421650)
location: region:418630-421650:-1
so has part: feature:418630-421650:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:418630-421650:-1:exon

YOR048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HKE1
alternative label: TAP1
alternative label: XRN2
gene: RAT1
locus tag: YOR048C
gene synonym: HKE1; TAP1; XRN2
experiment: EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004534 5'-3' exoribonuclease activity [PMID:8417335]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9315672|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0110155 NAD-cap decapping [PMID:35173156]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:9488433]
experiment: EXISTENCE:genetic interaction:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]
experiment: EXISTENCE:genetic interaction:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:24501251]
experiment: EXISTENCE:genetic interaction:GO:0043144 sno(s)RNA processing [PMID:9488433]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11030620]
experiment: EXISTENCE:genetic interaction:GO:1901408 negative regulation of phosphorylation of RNA polymerase II C-terminal domain [PMID:24501251]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:33978753]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11142370|PMID:9488433]
experiment: EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15565157]
experiment: EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]
experiment: EXISTENCE:mutant phenotype:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:24501251]
experiment: EXISTENCE:mutant phenotype:GO:0043144 sno(s)RNA processing [PMID:9488433]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:11030620|PMID:27124216]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16131592]
experiment: EXISTENCE:mutant phenotype:GO:1901408 negative regulation of phosphorylation of RNA polymerase II C-terminal domain [PMID:24501251]
note: Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation
codon start: 1
product: ssRNA exonuclease RAT1
translation: MGVPSFFRWLSRKYPKIISPVLEEQPQIVDGVILPLDYSASNPNGELDNLYLDMNGIVHPCSHPENKPPPETEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRFRSARDAQIENEAREEIMRQREEVGEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWTAFKLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIFLGLATHEPHFKILREDVFAQDNRKRNNLKDTINMTEEEKQFLQKQNSEQPFLWLHINVLREYLSAELWVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWKVVLPKLKTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHIQEARKKEAFERRKAQKNMSKGQDRHPTVATEQLQMYDTQGNLAKGSWNLTTSDMVRLKKELMLANEGNEEAIAKVKQQSDKNNELMKDISKEEIDDAVSKANKTNFNLAEVMKQKIINKKHRLEKDNEEEEIAKDSKKVKTEKAESECDLDAEIKDEIVADVNDRENSETTEVSRDSPVHSTVNVSEGPKNGVFDTDEFVKLFEPGYHERYYTAKFHVTPQDIEQLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATDFHGFSHLEIKFEEGTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPIDMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPLLSDAERARNIRGEPVLLISNKNANYERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSKDVEGFELNGKIVCPIQGGSLPNLSTTLILKMSYRLIPLPSRNKSIILNGFIPSEPVLTAYDLDSIMYKYNNQNYSRRWNFGNDLKQNIVPVGPKGITQYKPRTGGYRAFFYFAELSRNNVQPAHNYGRNSYNSQPGFNNSRYDGGNNNYRQNSNYRNNNYSGNRNSGQYSGNSYSRNNKQSRYDNSRANRR
SIO_010081: YOR048C
subclass of: SO_0000673
so part of: YOR048C
location: complement(418630..421650)
location: region:418630-421650:-1
so has part: feature:418630-421650:-1:exon

NP_014691.1
type: Protein
SIO_000068: ncbiprotein

S000005574
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:418630-421650:-1:exon

YOR049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSB1
locus tag: YOR049C
so part of: sequence
location: complement(<422668..>423732)
location: region:422668-423732:-1
so has part: feature:422668-423732:-1:exon
subclass of: SO_0000010

854214
type: Gene
SIO_000068: ncbigene

position:422668:-1
position: 422668
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:423732:-1
position: 423732
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:422668-423732:-1:exon

YOR049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSB1
locus tag: YOR049C
product: phospholipid-translocating ATPase RSB1
transcript id: NM_001183468.1
SIO_010081: YOR049C
subclass of: SO_0000673
so part of: YOR049C
location: complement(<422668..>423732)
location: region:422668-423732:-1
so has part: feature:422668-423732:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:422668-423732:-1:exon

YOR049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSB1
locus tag: YOR049C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005324 long-chain fatty acid transporter activity [PMID:28175317]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12034738]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12034738|PMID:16407254]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:12034738]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:24146988]
experiment: EXISTENCE:direct assay:GO:1905329 sphingoid long-chain base transport [PMID:12034738]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:15342785]
experiment: EXISTENCE:mutant phenotype:GO:1905329 sphingoid long-chain base transport [PMID:12034738]
note: Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation
codon start: 1
product: phospholipid-translocating ATPase RSB1
translation: MVPNLRFNITMIVIWGILLTIHVVQLLMRQYWFSIAFICTGILEVLGFIGRTWSHSNVADMDAFLLNMICLTIAPVFTMGGIYYQLAKLIEVYGHRFSLLPSPMAYSFIFICSDIVSLVVQAVGGGLCGVAVTDGTSTTTGNHVFIAGLAIQVASMAIFLMLWFHFLFRIYISVRWEHINSRPISLSLLKISQTEVDYLYREKFHFLRLEPKRWVFHYFNLAITVAVLTIFTRCCYRLAELVVGWDGYLITHEWYFIILDALMMAIATVTLTIFHPGFAFKGRSTSIPITPGHVDPETLPHTDDVEDILDTSDSKQFDIEKEEFQASMKYPISTFKQFMSKIANLFSSKKKAKL
SIO_010081: YOR049C
subclass of: SO_0000673
so part of: YOR049C
location: complement(422668..423732)
location: region:422668-423732:-1
so has part: feature:422668-423732:-1:exon

NP_014692.1
type: Protein
SIO_000068: ncbiprotein

S000005575
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:422668-423732:-1:exon

YOR051C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NRO1
alternative label: YOR29-02
gene: ETT1
locus tag: YOR051C
gene synonym: NRO1; YOR29-02
so part of: sequence
location: complement(<424846..>426084)
location: region:424846-426084:-1
so has part: feature:424846-426084:-1:exon
subclass of: SO_0000010

854216
type: Gene
SIO_000068: ncbigene

position:424846:-1
position: 424846
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426084:-1
position: 426084
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424846-426084:-1:exon

YOR051C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NRO1
alternative label: YOR29-02
gene: ETT1
locus tag: YOR051C
gene synonym: NRO1; YOR29-02
product: Ett1p
transcript id: NM_001183470.1
SIO_010081: YOR051C
subclass of: SO_0000673
so part of: YOR051C
location: complement(<424846..>426084)
location: region:424846-426084:-1
so has part: feature:424846-426084:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:424846-426084:-1:exon

YOR051C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NRO1
alternative label: YOR29-02
gene: ETT1
locus tag: YOR051C
gene synonym: NRO1; YOR29-02
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:14562095|PMID:26359986]
experiment: EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:20630870]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:20630870]
note: Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
codon start: 1
product: Ett1p
translation: MAKRPLGLGKQSREKKRKVESVEKKSDEPSRESTPVRSQMSVELDDDADLDDELAQLKGLWSKYFHSDRDDEYVLNGIVHECDRLLRLSEEDKEIKKTLNDIFHGIYALALSELTIFKAGDEEATEEKRKKDVSSFFESAIERVELGLSHFPESQFLKLVLAKIIFQRIPLEYISNLHLKSKDKKLDLVGQLEHGKKHFSIYENDTEFTFEILQMVNDLLDIVENFGREQSIQEGIDSDNEEEEELIDIELEPEHPVYPLQQSLEANYEWLRNHFDKLLDNTNTDVKIYASIANTLGELYLKKAEEPSKVFLSLQYDDGGSEKVSDKEAKNAQETALKHTKKALEYLEKAKLEDDPDTWVQVAEAYIDLGNLLDNESAEQEEAYKTAEEILGKANKASHGKFQDVLDNFLQG
SIO_010081: YOR051C
subclass of: SO_0000673
so part of: YOR051C
location: complement(424846..426084)
location: region:424846-426084:-1
so has part: feature:424846-426084:-1:exon

NP_014694.1
type: Protein
SIO_000068: ncbiprotein

S000005577
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424846-426084:-1:exon

YOR052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-03
gene: TMC1
locus tag: YOR052C
gene synonym: YOR29-03
so part of: sequence
location: complement(<426772..>427224)
location: region:426772-427224:-1
so has part: feature:426772-427224:-1:exon
subclass of: SO_0000010

854217
type: Gene
SIO_000068: ncbigene

position:426772:-1
position: 426772
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:427224:-1
position: 427224
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:426772-427224:-1:exon

YOR052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-03
gene: TMC1
locus tag: YOR052C
gene synonym: YOR29-03
product: Tmc1p
transcript id: NM_001183471.1
SIO_010081: YOR052C
subclass of: SO_0000673
so part of: YOR052C
location: complement(<426772..>427224)
location: region:426772-427224:-1
so has part: feature:426772-427224:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:426772-427224:-1:exon

YOR052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-03
gene: TMC1
locus tag: YOR052C
gene synonym: YOR29-03
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071218 cellular response to misfolded protein [PMID:27226598]
experiment: EXISTENCE:direct assay:GO:0071243 cellular response to arsenic-containing substance [PMID:27226598]
experiment: EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]
note: AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress
codon start: 1
product: Tmc1p
translation: MSDINEIEIPSRKDEIRQVTPKDPMHEIEDKSTYHAKIKKSDSGTVLGAIPLNSRSSSNSSVTSTGQSSRRVTKKTTKKKKKNACYFDTCSSAASKFIGDCNFCKGHFCSKHRLMENHACNGLTSCKEQLHQRNADKLEAEQTKAPKIQI
SIO_010081: YOR052C
subclass of: SO_0000673
so part of: YOR052C
location: complement(426772..427224)
location: region:426772-427224:-1
so has part: feature:426772-427224:-1:exon

NP_014695.1
type: Protein
SIO_000068: ncbiprotein

S000005578
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:426772-427224:-1:exon

YOR054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-05
gene: VHS3
locus tag: YOR054C
gene synonym: YOR29-05
so part of: sequence
location: complement(<427833..>429857)
location: region:427833-429857:-1
so has part: feature:427833-429857:-1:exon
subclass of: SO_0000010

854220
type: Gene
SIO_000068: ncbigene

position:427833:-1
position: 427833
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:429857:-1
position: 429857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427833-429857:-1:exon

YOR054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-05
gene: VHS3
locus tag: YOR054C
gene synonym: YOR29-05
product: phosphopantothenoylcysteine decarboxylase complex subunit VHS3
transcript id: NM_001183473.1
SIO_010081: YOR054C
subclass of: SO_0000673
so part of: YOR054C
location: complement(<427833..>429857)
location: region:427833-429857:-1
so has part: feature:427833-429857:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427833-429857:-1:exon

YOR054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-05
gene: VHS3
locus tag: YOR054C
gene synonym: YOR29-05
experiment: EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:0004864 protein phosphatase inhibitor activity [PMID:15192104]
experiment: EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]
experiment: EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19915539]
experiment: EXISTENCE:genetic interaction:GO:0030004 cellular monovalent inorganic cation homeostasis [PMID:15192104]
experiment: EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
experiment: EXISTENCE:physical interaction:GO:0030004 cellular monovalent inorganic cation homeostasis [PMID:15192104]
note: Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)
codon start: 1
product: phosphopantothenoylcysteine decarboxylase complex subunit VHS3
translation: MTNKSSLKNNRKGVASNTLSGAEQANIGSSAMPDTNSTGPFSSVSSLDTPVVRKSTSPTGSQTKSIMNASGTSGAVVSNTPEPGLKRIPTVTFSDPKLGSLRSDVEQTPPNQVARQSSEKKATSVHIAAEGANQGRNLKDINTKVPKDGEASASSFSTPTSILSNADMGNNISSLLAKKLSFTGGTDSILNSDNSSDSPRKEHPHFYVEDPLHTPSVRSRSNSTSPRPSVVVNTFNPINIEREGSISKTGEPTLLESVLEEAMSPNAVSNPLKRENIMTNMDPRLPQDDGKLHVLFGATGSLSVFKLKHMIRKLEEIYGRDKICIQVILTNSATKFFAMKYMRKNKKQHNSIDTSFNSTNSNAGNITGNKKKVASLEKFSIQKTSSNSAASQTNNKQEEEKQMASTTGFPSTLGGSRTYSNSSNVVSQHPQIELPAHIQFWTDQDEWDVWRQRTDPVLHIELRRWADILVVAPLTANTLAKIALGLCDNLLTSVIRAWNPTFPIFLAPSMGSGTFNSIMTKKHFRIIQEEMPWVTVFKPSEKVMGINGDIGLSGMMDANEIVGKIVVKLGGYPDVSAGKEEEEDEDNDEEDDNKKNDTGGKDEDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEDEDEDDEGKKKEDKGGLQRS
SIO_010081: YOR054C
subclass of: SO_0000673
so part of: YOR054C
location: complement(427833..429857)
location: region:427833-429857:-1
so has part: feature:427833-429857:-1:exon

NP_014697.1
type: Protein
SIO_000068: ncbiprotein

S000005580
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427833-429857:-1:exon

YOR056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-07
gene: NOB1
locus tag: YOR056C
gene synonym: YOR29-07
so part of: sequence
location: complement(<430247..>431626)
location: region:430247-431626:-1
so has part: feature:430247-431626:-1:exon
subclass of: SO_0000010

854221
type: Gene
SIO_000068: ncbigene

position:430247:-1
position: 430247
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:431626:-1
position: 431626
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:430247-431626:-1:exon

YOR056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-07
gene: NOB1
locus tag: YOR056C
gene synonym: YOR29-07
product: rRNA-binding endoribonuclease
transcript id: NM_001183475.1
SIO_010081: YOR056C
subclass of: SO_0000673
so part of: YOR056C
location: complement(<430247..>431626)
location: region:430247-431626:-1
so has part: feature:430247-431626:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:430247-431626:-1:exon

YOR056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-07
gene: NOB1
locus tag: YOR056C
gene synonym: YOR29-07
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:19801658]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12502737|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030490 maturation of SSU-rRNA [PMID:19801658]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:12588997]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:19706509]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12588997|PMID:15388878]
experiment: EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12502737]
experiment: EXISTENCE:physical interaction:GO:0043248 proteasome assembly [PMID:12502737]
note: Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
codon start: 1
product: rRNA-binding endoribonuclease
translation: MTENQTAHVRALILDATPLITQSYTHYQNYAQSFYTTPTVFQEIKDAQARKNLEIWQSLGTLKLVHPSENSIAKVSTFAKLTGDYSVLSANDLHILALTYELEIKLNNGDWRLRKKPGDALDASKADVGTDGKQKLTEDNKKEEDSESVPKKKNKRRGGKKQKAKREAREAREAENANLELESKAEEHVEEAGSKEQICNDENIKESSDLNEVFEDADDDGDWITPENLTEAIIKDSGEDTTGSLGVEASEEDRHVALNRPENQVALATGDFAVQNVALQMNLNLMNFMSGLKIKRIRNYMLRCHACFKIFPLPKDGKPKHFCASCGGQGTLLRCAVSVDSRTGNVTPHLKSNFQWNNRGNRYSVASPLSKNSQKRYGKKGHVHSKPQENVILREDQKEYEKVIKQEEWTRRHNEKILNNWIGGGSADNYISPFAITGLKQHNVRIGKGRYVNSSKRRS
SIO_010081: YOR056C
subclass of: SO_0000673
so part of: YOR056C
location: complement(430247..431626)
location: region:430247-431626:-1
so has part: feature:430247-431626:-1:exon

NP_014699.1
type: Protein
SIO_000068: ncbiprotein

S000005582
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:430247-431626:-1:exon

YOR057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SGT1
locus tag: YOR057W
so part of: sequence
location: <432186..>433373
location: region:432186-433373:1
so has part: feature:432186-433373:1:exon
subclass of: SO_0000010

854222
type: Gene
SIO_000068: ncbigene

position:432186:1
position: 432186
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433373:1
position: 433373
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432186-433373:1:exon

YOR057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SGT1
locus tag: YOR057W
product: co-chaperone SGT1
transcript id: NM_001183476.1
SIO_010081: YOR057W
subclass of: SO_0000673
so part of: YOR057W
location: <432186..>433373
location: region:432186-433373:1
so has part: feature:432186-433373:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432186-433373:1:exon

YOR057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SGT1
locus tag: YOR057W
experiment: EXISTENCE:direct assay:GO:0000151 ubiquitin ligase complex [PMID:10445024]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:34192536]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:34192536]
experiment: EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:34192536]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:16945921]
experiment: EXISTENCE:direct assay:GO:0051087 chaperone binding [PMID:16945921|PMID:34192536]
experiment: EXISTENCE:direct assay:GO:0051382 kinetochore assembly [PMID:10445024]
experiment: EXISTENCE:direct assay:GO:0065003 protein-containing complex assembly [PMID:15090617]
note: Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
codon start: 1
product: co-chaperone SGT1
translation: MPVEKDLKTAYKALYDEKEPLKALHLYDEILKGSPTNLTALIFKAACLEKLYFGFSDWHSDATMENAKELLDKALMTAEGRGDRSKIGLVNFRYFVHFFNIKDYELAQSYFKKAKNLGYVDDTLPLWEDRLETKLNKKNKKQKDSTNKHTIKPVESIENRGDNNSSHSPISPLKIETAPQESPKFKIDWYQSSTSVTISLFTVNLPESKEQVNIYISPNDRRTLSISYQVPKSGSEFQYNAKLSHEVDPKAVSLKIFPKKLEITLSKIDSTQWKKLEEDILTESSRLSDEGKNSDSATRLLSAETASKERLSYPSSSKKKIDWSKLDIDEEADEEAGSADSFFQKLYAGADPDTKRAMMKSFIESNGTALSTDWEDVSKGTVKTSPPEGMEPKHW
SIO_010081: YOR057W
subclass of: SO_0000673
so part of: YOR057W
location: 432186..433373
location: region:432186-433373:1
so has part: feature:432186-433373:1:exon

NP_014700.1
type: Protein
SIO_000068: ncbiprotein

S000005583
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432186-433373:1:exon

YOR058C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-09
gene: ASE1
locus tag: YOR058C
gene synonym: YOR29-09
so part of: sequence
location: complement(<433688..>436345)
location: region:433688-436345:-1
so has part: feature:433688-436345:-1:exon
subclass of: SO_0000010

854223
type: Gene
SIO_000068: ncbigene

position:433688:-1
position: 433688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436345:-1
position: 436345
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:433688-436345:-1:exon

YOR058C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-09
gene: ASE1
locus tag: YOR058C
gene synonym: YOR29-09
product: Ase1p
transcript id: NM_001183477.1
SIO_010081: YOR058C
subclass of: SO_0000673
so part of: YOR058C
location: complement(<433688..>436345)
location: region:433688-436345:-1
so has part: feature:433688-436345:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:433688-436345:-1:exon

YOR058C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-09
gene: ASE1
locus tag: YOR058C
gene synonym: YOR29-09
experiment: EXISTENCE:direct assay:GO:0001578 microtubule bundle formation [PMID:12591913]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005819 spindle [PMID:7559759]
experiment: EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:7559759]
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:12591913]
experiment: EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:7559759]
experiment: EXISTENCE:genetic interaction:GO:0000022 mitotic spindle elongation [PMID:7559759]
experiment: EXISTENCE:genetic interaction:GO:0000073 initial mitotic spindle pole body separation [PMID:16688214]
experiment: EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:12591913|PMID:7559759]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:16615892]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9036857]
experiment: EXISTENCE:mutant phenotype:GO:0051255 spindle midzone assembly [PMID:17562791]
note: Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
codon start: 1
product: Ase1p
translation: METATSSPLPIKSRRNSENSGSTTVIPHMNPSLATPLTVSTMVNQSNSKEFMKLTPVRIRDFGSPLKNVSTNYHFLDSENGKGNTMDNMYRENFILISKDLEKLLENLNVIYQNIGYSNTEIITKEKIIFTTISNSIKQFFEQADEELKRLSAENGIEQDILNNILERINDPSGIKTIPDLYIRNAILLQESKTVPQSPKKPLSLLSKKAALDTAKKFVLGSFLPRLRDYLKSLITLKHLIQSVKENLPGLTEADNEAIAEFPELSTLTAYLLQIENGKGDIGLSMKFIIDNRKDILKGSAFKTINEESVKHMNEVIKIYEEEYERRFKSVLTKKVSISSICEQLGTPLATLIGEDFEQDLRSYGEEENSTSEIPNFHPVDRERMSKIDITLEKLQAIHKERADKKRLLMEQCQKLWTRLKISQEYIKTFMRNNSSLSTESLGRISKEVMRLEAMKKKLIKKLISDSWDKIQELWRTLQYSEESRSKFIIVFEELRNSATTLQEDELLLETCENELKRLEEKLTLYKPILKLISDFESLQEDQEFLERSSKDSSRLLSRNSHKILLTEEKMRKRITRHFPRVINDLRIKLEEADGLFDQPFLFKGKPLSEAIDIQQQEIEAKYPRCRVRMQRSKKGKCGANKENKVIKNTFKATESSIRVPIGLNLNDANITYKTPSKKTIQGLTKNDLSQENSLARHMQGTTKLSSPNRRATRLLAPTVISRNSKGNIERPTLNRNRSSDLSSSPRINHTHGEHAVKPRQLFPIPLNKVDTKGSHIPQLTKEKALELLKRSTGTTGKENVRSPERKSSLEDYAQKLSSPYKEPEHSIYKLSMSPEGKFQLNIQQKDIESGFDDTSMMEDENDKDFITWKNEQVSKLNGFSFTDI
SIO_010081: YOR058C
subclass of: SO_0000673
so part of: YOR058C
location: complement(433688..436345)
location: region:433688-436345:-1
so has part: feature:433688-436345:-1:exon

NP_116582.1
type: Protein
SIO_000068: ncbiprotein

S000005584
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:433688-436345:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(438175..438483)
location: region:438175-438483:-1
so has part: feature:438175-438483:-1:region

S000007162
type: SGD
SIO_000068: sgd

position:438175:-1
position: 438175
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:438483:-1
position: 438483
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438175-438483:-1:region

YNCO0016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0016W
so part of: sequence
location: 438643..438738
location: region:438643-438738:1
so has part: feature:438643-438738:1:exon
subclass of: SO_0000663

854224
type: Gene
SIO_000068: ncbigene

position:438643:1
position: 438643
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:438738:1
position: 438738
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438643-438738:1:exon

YNCO0016W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0016W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCO0016W
subclass of: SO_0000673
so part of: YNCO0016W
location: join(438643..438679,438703..438738)
location: region:438643-438738:1
so has part: feature:438643-438679:1:exon
so has part: feature:438703-438738:1:exon

S000006634
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438643-438679:1:exon

position:438679:1
position: 438679
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:438703-438738:1:exon

position:438703:1
position: 438703
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOR059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-10
gene: LPL1
locus tag: YOR059C
gene synonym: YOR29-10
so part of: sequence
location: complement(<438906..>440258)
location: region:438906-440258:-1
so has part: feature:438906-440258:-1:exon
subclass of: SO_0000010

854225
type: Gene
SIO_000068: ncbigene

position:438906:-1
position: 438906
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440258:-1
position: 440258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438906-440258:-1:exon

YOR059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-10
gene: LPL1
locus tag: YOR059C
gene synonym: YOR29-10
product: putative hydrolase
transcript id: NM_001183478.1
SIO_010081: YOR059C
subclass of: SO_0000673
so part of: YOR059C
location: complement(<438906..>440258)
location: region:438906-440258:-1
so has part: feature:438906-440258:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:438906-440258:-1:exon

YOR059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-10
gene: LPL1
locus tag: YOR059C
gene synonym: YOR29-10
EC number: 3.1.1.4
experiment: EXISTENCE:direct assay:GO:0004622 lysophospholipase activity [PMID:25014274]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093|PMID:25014274]
experiment: EXISTENCE:mutant phenotype:GO:0004622 lysophospholipase activity [PMID:25014274]
experiment: EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:25014274]
note: Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative hydrolase
translation: MTSDKHLFVLIHGLWGNYTHMESMRTILSTTLKKEDVNDDMIYFLPKQNAMFKTFDGIEIIGYRTLIEVCEFIRDYKDGKITKLSVMGYSQGGLVARFMIGKMLTEFKELFEDIEPQLFITMATPHLGVEFYNPTGIAYKSALYSALRTLGSTILGKSGREMFIANSSNNILVKLSQGEYLEALSLFKWRIAFANVKNDRTVAFYTAFITDCDPFIDFDNKLKYTFEEKIPGSGYKGILPKIVDLNALNVNSHAPTKPTKTYKKWGRTILIILVATFLILPIALVMNGLGTAYSYIVTCKYRKMLSNGILHNEVRGKLGLTEQLKGYVTDAYGSIINSALDMDANYEASNSNLVNEEELPWKEFIQKYTTINDGVWKSKFKKLPFDENRKVILRNLNKLKWIRVPIYIKAVNAHGVIVARRGMDENTAATGIACIEFTAQLLAYLMHKSN
SIO_010081: YOR059C
subclass of: SO_0000673
so part of: YOR059C
location: complement(438906..440258)
location: region:438906-440258:-1
so has part: feature:438906-440258:-1:exon

NP_014702.1
type: Protein
SIO_000068: ncbiprotein

S000005585
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438906-440258:-1:exon

YOR060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-11
gene: SLD7
locus tag: YOR060C
gene synonym: YOR29-11
so part of: sequence
location: complement(<440390..>441163)
location: region:440390-441163:-1
so has part: feature:440390-441163:-1:exon
subclass of: SO_0000010

854226
type: Gene
SIO_000068: ncbigene

position:440390:-1
position: 440390
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:441163:-1
position: 441163
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440390-441163:-1:exon

YOR060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-11
gene: SLD7
locus tag: YOR060C
gene synonym: YOR29-11
product: Sld7p
transcript id: NM_001183479.1
SIO_010081: YOR060C
subclass of: SO_0000673
so part of: YOR060C
location: complement(<440390..>441163)
location: region:440390-441163:-1
so has part: feature:440390-441163:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440390-441163:-1:exon

YOR060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-11
gene: SLD7
locus tag: YOR060C
gene synonym: YOR29-11
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:21487389]
experiment: EXISTENCE:genetic interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:21487389]
experiment: EXISTENCE:physical interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:21487389]
note: Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor
codon start: 1
product: Sld7p
translation: MSRKLCTLNFTLSGKQGSLVIRDIQLWSNRPTASKSTSELRGQFIQYVDLAKLPLWVRSTNMNTYRCYSTSATAQAYFKSKLRNANRGIVIELFDKVDQRSQEPAYLIIFRENTELNCFQVDLTMKHEFDGQVTKLKQDIGKTRASVSKEGSIDIIIQQSQQRKIGTKTEVYRNVHINDKRLQFNETLSKLILGGLRLRGISNSITDYQKLYKITFDAAEFTHRDELKRISMGSGEEVSFESLQETVETLLKLFTKS
SIO_010081: YOR060C
subclass of: SO_0000673
so part of: YOR060C
location: complement(440390..441163)
location: region:440390-441163:-1
so has part: feature:440390-441163:-1:exon

NP_014703.1
type: Protein
SIO_000068: ncbiprotein

S000005586
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440390-441163:-1:exon

YOR061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-12
gene: CKA2
locus tag: YOR061W
gene synonym: YOR29-12
so part of: sequence
location: <441534..>442553
location: region:441534-442553:1
so has part: feature:441534-442553:1:exon
subclass of: SO_0000010

854227
type: Gene
SIO_000068: ncbigene

position:441534:1
position: 441534
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442553:1
position: 442553
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441534-442553:1:exon

YOR061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-12
gene: CKA2
locus tag: YOR061W
gene synonym: YOR29-12
product: casein kinase 2 catalytic subunit CKA2
transcript id: NM_001183480.1
SIO_010081: YOR061W
subclass of: SO_0000673
so part of: YOR061W
location: <441534..>442553
location: region:441534-442553:1
so has part: feature:441534-442553:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441534-442553:1:exon

YOR061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-12
gene: CKA2
locus tag: YOR061W
gene synonym: YOR29-12
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8226802]
experiment: EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]
experiment: EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006974 cellular response to DNA damage stimulus [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]
experiment: EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:22496671]
experiment: EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:24817120]
note: Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
codon start: 1
product: casein kinase 2 catalytic subunit CKA2
translation: MPLPPSTLNQKSNRVYSVARVYKNACEERPQEYWDYEQGVTIDWGKISNYEIINKIGRGKYSEVFSGRCIVNNQKCVIKVLKPVKMKKIYRELKILTNLTGGPNVVGLYDIVQDADSKIPALIFEEIKNVDFRTLYPTFKLPDIQYYFTQLLIALDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAEFYHPGVDYNVRVASRYHKGPELLVNLNQYDYSLDLWSVGCMLAAIVFKKEPFFKGSSNPDQLVKIATVLGTKELLGYLGKYGLHLPSEYDNIMRDFTKKSWTHFITSETKLAVPEVVDLIDNLLRYDHQERLTAKEAMDHKFFKTKFE
SIO_010081: YOR061W
subclass of: SO_0000673
so part of: YOR061W
location: 441534..442553
location: region:441534-442553:1
so has part: feature:441534-442553:1:exon

NP_014704.1
type: Protein
SIO_000068: ncbiprotein

S000005587
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441534-442553:1:exon

YOR062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-13
locus tag: YOR062C
gene synonym: YOR29-13
so part of: sequence
location: complement(<442725..>443531)
location: region:442725-443531:-1
so has part: feature:442725-443531:-1:exon
subclass of: SO_0000010

854228
type: Gene
SIO_000068: ncbigene

position:442725:-1
position: 442725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:443531:-1
position: 443531
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442725-443531:-1:exon

YOR062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-13
locus tag: YOR062C
gene synonym: YOR29-13
product: uncharacterized protein
transcript id: NM_001183481.1
SIO_010081: YOR062C
subclass of: SO_0000673
so part of: YOR062C
location: complement(<442725..>443531)
location: region:442725-443531:-1
so has part: feature:442725-443531:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:442725-443531:-1:exon

YOR062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-13
locus tag: YOR062C
gene synonym: YOR29-13
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MTSLDDSVLTKKNIALLDNATNYIRPAIDYFHFKFNYDSLDVSTTWRLLLKMRKHKLLRLPSCSSENEFDYSIYMARLYHCIWRRWSIKHFNLDEYKIDPLSINWNKEIDVTVLYGPDLVGIHEREQPTPTDFPMGNIKEQGKQLLDVRKEGSASSLLKKGSVFYSKGKWLSQRSISFDDTVRRRDIDKRGRFRESCVLINDVEQFQNYSIVWDESRHRYRRQALPDTYDYEHLYPNGDETPRNTPHDNIIIHQNLHSITEGSYIYIK
SIO_010081: YOR062C
subclass of: SO_0000673
so part of: YOR062C
location: complement(442725..443531)
location: region:442725-443531:-1
so has part: feature:442725-443531:-1:exon

NP_014705.1
type: Protein
SIO_000068: ncbiprotein

S000005588
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:442725-443531:-1:exon

YOR063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAK8
alternative label: TCM1
alternative label: YOR29-14
gene: RPL3
locus tag: YOR063W
gene synonym: MAK8; TCM1; YOR29-14
so part of: sequence
location: <444686..>445849
location: region:444686-445849:1
so has part: feature:444686-445849:1:exon
subclass of: SO_0000010

854229
type: Gene
SIO_000068: ncbigene

position:444686:1
position: 444686
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:445849:1
position: 445849
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:444686-445849:1:exon

YOR063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAK8
alternative label: TCM1
alternative label: YOR29-14
gene: RPL3
locus tag: YOR063W
gene synonym: MAK8; TCM1; YOR29-14
product: ribosomal 60S subunit protein L3
transcript id: NM_001183482.1
SIO_010081: YOR063W
subclass of: SO_0000673
so part of: YOR063W
location: <444686..>445849
location: region:444686-445849:1
so has part: feature:444686-445849:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:444686-445849:1:exon

YOR063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAK8
alternative label: TCM1
alternative label: YOR29-14
gene: RPL3
locus tag: YOR063W
gene synonym: MAK8; TCM1; YOR29-14
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:3537704]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:26826131]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:9858562|PMID:26826131]
note: Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus
codon start: 1
product: ribosomal 60S subunit protein L3
translation: MSHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDLDRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVLVHTQIRKTPLAQKKAHLAEIQLNGGSISEKVDWAREHFEKTVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDRTKKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWIDTASKFGKGRFQTPAEKHAFMGTLKKDL
SIO_010081: YOR063W
subclass of: SO_0000673
so part of: YOR063W
location: 444686..445849
location: region:444686-445849:1
so has part: feature:444686-445849:1:exon

NP_014706.1
type: Protein
SIO_000068: ncbiprotein

S000005589
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:444686-445849:1:exon

YOR064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-15
gene: YNG1
locus tag: YOR064C
gene synonym: YOR29-15
so part of: sequence
location: complement(<446079..>446738)
location: region:446079-446738:-1
so has part: feature:446079-446738:-1:exon
subclass of: SO_0000010

854230
type: Gene
SIO_000068: ncbigene

position:446079:-1
position: 446079
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:446738:-1
position: 446738
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446079-446738:-1:exon

YOR064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-15
gene: YNG1
locus tag: YOR064C
gene synonym: YOR29-15
product: Yng1p
transcript id: NM_001183483.1
SIO_010081: YOR064C
subclass of: SO_0000673
so part of: YOR064C
location: complement(<446079..>446738)
location: region:446079-446738:-1
so has part: feature:446079-446738:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:446079-446738:-1:exon

YOR064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-15
gene: YNG1
locus tag: YOR064C
gene synonym: YOR29-15
experiment: EXISTENCE:direct assay:GO:0016573 histone acetylation [PMID:12077334]
experiment: EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:16923967|PMID:17157260]
experiment: EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:25104842]
experiment: EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:12077334]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10805724]
experiment: EXISTENCE:mutant phenotype:GO:0035064 methylated histone binding [PMID:17157260]
experiment: EXISTENCE:physical interaction:GO:0033100 NuA3 histone acetyltransferase complex [PMID:12077334]
note: Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region
codon start: 1
product: Yng1p
translation: MEHLANENSDSDIRYSFLSTLDHLPCELIRSLRLMQTIDLFKNEEDEPGMERACRDLLLVATYINDLVDDQIHFLKQHKKELEIQKSVTKNFNSSLENIKSKLTLEEPGAYKEPKLLLKINLKKAKSRERKESITSPTIGINQGDVTEGNNNQEEVYCFCRNVSYGPMVACDNPACPFEWFHYGCVGLKQAPKGKWYCSKDCKEIANQRSKSKRQKRRK
SIO_010081: YOR064C
subclass of: SO_0000673
so part of: YOR064C
location: complement(446079..446738)
location: region:446079-446738:-1
so has part: feature:446079-446738:-1:exon

NP_014707.1
type: Protein
SIO_000068: ncbiprotein

S000005590
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:446079-446738:-1:exon

YOR065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTC1
alternative label: YOR29-16
gene: CYT1
locus tag: YOR065W
gene synonym: CTC1; YOR29-16
so part of: sequence
location: <447439..>448368
location: region:447439-448368:1
so has part: feature:447439-448368:1:exon
subclass of: SO_0000010

854231
type: Gene
SIO_000068: ncbigene

position:447439:1
position: 447439
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:448368:1
position: 448368
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447439-448368:1:exon

YOR065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTC1
alternative label: YOR29-16
gene: CYT1
locus tag: YOR065W
gene synonym: CTC1; YOR29-16
product: ubiquinol--cytochrome-c reductase catalytic subunit CYT1
transcript id: NM_001183484.1
SIO_010081: YOR065W
subclass of: SO_0000673
so part of: YOR065W
location: <447439..>448368
location: region:447439-448368:1
so has part: feature:447439-448368:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447439-448368:1:exon

YOR065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTC1
alternative label: YOR29-16
gene: CYT1
locus tag: YOR065W
gene synonym: CTC1; YOR29-16
EC number: 7.1.1.8
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005750 mitochondrial respiratory chain complex III [PMID:10873857]
experiment: EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:11279090]
experiment: EXISTENCE:mutant phenotype:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:11279090]
note: Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
codon start: 1
product: ubiquinol--cytochrome-c reductase catalytic subunit CYT1
translation: MFSNLSKRWAQRTLSKSFYSTATGAASKSGKLTQKLVTAGVAAAGITASTLLYADSLTAEAMTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVCAACHSLDRVAWRTLVGVSHTNEEVRNMAEEFEYDDEPDEQGNPKKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLIVKARHGGCDYIFSLLTGYPDEPPAGVALPPGSNYNPYFPGGSIAMARVLFDDMVEYEDGTPATTSQMAKDVTTFLNWCAEPEHDERKRLGLKTVIILSSLYLLSIWVKKFKWAGIKTRKFVFNPPKPRK
SIO_010081: YOR065W
subclass of: SO_0000673
so part of: YOR065W
location: 447439..448368
location: region:447439-448368:1
so has part: feature:447439-448368:1:exon

NP_014708.1
type: Protein
SIO_000068: ncbiprotein

S000005591
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447439-448368:1:exon

YOR066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-17
gene: MSA1
locus tag: YOR066W
gene synonym: YOR29-17
so part of: sequence
location: <449436..>451325
location: region:449436-451325:1
so has part: feature:449436-451325:1:exon
subclass of: SO_0000010

854232
type: Gene
SIO_000068: ncbigene

position:449436:1
position: 449436
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451325:1
position: 451325
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449436-451325:1:exon

YOR066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-17
gene: MSA1
locus tag: YOR066W
gene synonym: YOR29-17
product: Msa1p
transcript id: NM_001183485.1
SIO_010081: YOR066W
subclass of: SO_0000673
so part of: YOR066W
location: <449436..>451325
location: region:449436-451325:1
so has part: feature:449436-451325:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:449436-451325:1:exon

YOR066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-17
gene: MSA1
locus tag: YOR066W
gene synonym: YOR29-17
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19520826]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]
experiment: EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:18160399]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18160399]
experiment: EXISTENCE:mutant phenotype:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:18160399]
experiment: EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:18160399]
experiment: EXISTENCE:physical interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:18160399]
note: Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication
codon start: 1
product: Msa1p
translation: MDKSMIKKRGRPPITKDYPNPLQSPMAHSSMQVQKQGPHSFAKPLMKVGQSSPSPNKRRLSIDHHHNLAATTRKGRYRGVLLSTPTKKSSTNGSTPISTPSSNDSYNNTVFSETRKTFLQSSPPIMTSSPAFQKKNDYMFPSQEQFKLSLTITESGKAVIAGSLPFSPSSKSSHLMNNNNKKIMQNEKIHKGSKKNAPKFEKRRILSLLKQMKNEKYCDTDTLPEAPPAKPSRSDIIDTELPTIIETSASPIGSARNNNILLSQPPQSPPSSAQLKPPSTPKSSLQFRMGFTPNVALNSVSLSDTISKSTNAVGASNNNNQNGNSISNIADANTLLTLTNSPGVFLSPRNKMLPKSTTASNEQQQEFVFKFSSGDPLLLTDDADGNWPEMLFNVSNTPRRQKCFNTPPSWINFGSPGLFSPPRSSNVMVNGTTVATASDSGNVHRQLQAQLEAQVQVQSQSNSPTQRQQQQRQFQIPPPHINMNSSPPQINIASPPHQSMSRVSSIYFNKEKTTTGVANMLGNTKSENLQPPANLFTAAHGPSTPRNQEFQLPTLIECTPLIQQTMNGSLGTKYIPGTSISNSATPNLHGFPVGTGKAPSSFDDSLKQNPYSNKQDDARTALKRLIDDQ
SIO_010081: YOR066W
subclass of: SO_0000673
so part of: YOR066W
location: 449436..451325
location: region:449436-451325:1
so has part: feature:449436-451325:1:exon

NP_014709.1
type: Protein
SIO_000068: ncbiprotein

S000005592
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:449436-451325:1:exon

YOR067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-18
gene: ALG8
locus tag: YOR067C
gene synonym: YOR29-18
so part of: sequence
location: complement(<451729..>453462)
location: region:451729-453462:-1
so has part: feature:451729-453462:-1:exon
subclass of: SO_0000010

854233
type: Gene
SIO_000068: ncbigene

position:451729:-1
position: 451729
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453462:-1
position: 453462
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451729-453462:-1:exon

YOR067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-18
gene: ALG8
locus tag: YOR067C
gene synonym: YOR29-18
product: dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
transcript id: NM_001183486.1
SIO_010081: YOR067C
subclass of: SO_0000673
so part of: YOR067C
location: complement(<451729..>453462)
location: region:451729-453462:-1
so has part: feature:451729-453462:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:451729-453462:-1:exon

YOR067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-18
gene: ALG8
locus tag: YOR067C
gene synonym: YOR29-18
EC number: 2.4.1.265
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:8016100]
experiment: EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:8016100]
experiment: EXISTENCE:mutant phenotype:GO:0006490 oligosaccharide-lipid intermediate biosynthetic process [PMID:3536907]
experiment: EXISTENCE:mutant phenotype:GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [PMID:3536907]
note: Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant
codon start: 1
product: dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase
translation: MKGDRSRQNMAVTKKAKLKKNDEPKKVLKTAATEKGEGSKRYSLWNFWISTLFLKLLLIPDYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWFLSQFVPKSVRDDGCLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVASSIVLSPGFLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYFVFLLRAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFSRGLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAANNNGSKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKRFVGSLTLCGLASFLFGWHVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIKTLYTYVWCIIYFAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFLQKFEFLGLMIYSVYCSLGIISSWFALSWLYNFDELLWQ
SIO_010081: YOR067C
subclass of: SO_0000673
so part of: YOR067C
location: complement(451729..453462)
location: region:451729-453462:-1
so has part: feature:451729-453462:-1:exon

NP_014710.1
type: Protein
SIO_000068: ncbiprotein

S000005593
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451729-453462:-1:exon

YOR069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GRD2
alternative label: PEP10
alternative label: VPT5
gene: VPS5
locus tag: YOR069W
gene synonym: GRD2; PEP10; VPT5
so part of: sequence
location: <453768..>455795
location: region:453768-455795:1
so has part: feature:453768-455795:1:exon
subclass of: SO_0000010

854235
type: Gene
SIO_000068: ncbigene

position:453768:1
position: 453768
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:455795:1
position: 455795
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:453768-455795:1:exon

YOR069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GRD2
alternative label: PEP10
alternative label: VPT5
gene: VPS5
locus tag: YOR069W
gene synonym: GRD2; PEP10; VPT5
product: sorting nexin 1
transcript id: NM_001183488.1
SIO_010081: YOR069W
subclass of: SO_0000673
so part of: YOR069W
location: <453768..>455795
location: region:453768-455795:1
so has part: feature:453768-455795:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:453768-455795:1:exon

YOR069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GRD2
alternative label: PEP10
alternative label: VPT5
gene: VPS5
locus tag: YOR069W
gene synonym: GRD2; PEP10; VPT5
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:9175702|PMID:9700157]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9175702]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]
experiment: EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030905 retromer, tubulation complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]
note: Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication
codon start: 1
product: sorting nexin 1
translation: MDYEDNLEAPVWDELNHEGDKTQSLVSNSIESIGQISTNEERKDNELLETTASFADKIDLDSAPEWKDPGLSVAGNPQLEEHDNSKADDLINSLAPEQDPIADLKNSTTQFIATRESGGALFTGNANSPLVFDDTIYDANTSPNTSKSISGRRSGKPRILFDSARAQRNSKRNHSLKAKRTTASDDTIKTPFTDPLKKAEKENEFVEEPLDDRNERRENNEGKFTASVEKNILEQVDRPLYNLPQTGANISSPAEVEENSEKFGKTKIGSKVPPTEKAVAFKVEVKDPVKVGELTSIHVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENRRFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQLLGAEDAAEVLKNGGIDAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLSKSLEMVDTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIKDEFQGFSTDKIREFRNGMEISLEAAIESQKECIELWETFYQTNL
SIO_010081: YOR069W
subclass of: SO_0000673
so part of: YOR069W
location: 453768..455795
location: region:453768-455795:1
so has part: feature:453768-455795:1:exon

NP_014712.2
type: Protein
SIO_000068: ncbiprotein

S000005595
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:453768-455795:1:exon

YOR068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VAM10
locus tag: YOR068C
so part of: sequence
location: complement(<453869..>454213)
location: region:453869-454213:-1
so has part: feature:453869-454213:-1:exon
subclass of: SO_0000010

854234
type: Gene
SIO_000068: ncbigene

position:453869:-1
position: 453869
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454213:-1
position: 454213
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:453869-454213:-1:exon

YOR068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VAM10
locus tag: YOR068C
product: Vam10p
transcript id: NM_001183487.1
SIO_010081: YOR068C
subclass of: SO_0000673
so part of: YOR068C
location: complement(<453869..>454213)
location: region:453869-454213:-1
so has part: feature:453869-454213:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:453869-454213:-1:exon

YOR068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VAM10
locus tag: YOR068C
experiment: EXISTENCE:curator inference:GO:0000329 fungal-type vacuole membrane [PMID:12748377]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:12748377]
note: Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
codon start: 1
product: Vam10p
translation: MLFEVFGEVLASYIVSSKTKGELAFPVNNAPPDSLVAINCVVLFLRSAIGSCSGAKELIRSSALELSCSSSCGLPATDKPGSFHSGALSKSILSANEAVVSKSSLSFLSSFVDI
SIO_010081: YOR068C
subclass of: SO_0000673
so part of: YOR068C
location: complement(453869..454213)
location: region:453869-454213:-1
so has part: feature:453869-454213:-1:exon

NP_014711.1
type: Protein
SIO_000068: ncbiprotein

S000005594
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:453869-454213:-1:exon

YOR070C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-21
gene: GYP1
locus tag: YOR070C
gene synonym: YOR29-21
so part of: sequence
location: complement(<455907..>457820)
location: region:455907-457820:-1
so has part: feature:455907-457820:-1:exon
subclass of: SO_0000010

854236
type: Gene
SIO_000068: ncbigene

position:455907:-1
position: 455907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457820:-1
position: 457820
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455907-457820:-1:exon

YOR070C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-21
gene: GYP1
locus tag: YOR070C
gene synonym: YOR29-21
product: GTPase-activating protein GYP1
transcript id: NM_001183489.1
SIO_010081: YOR070C
subclass of: SO_0000673
so part of: YOR070C
location: complement(<455907..>457820)
location: region:455907-457820:-1
so has part: feature:455907-457820:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:455907-457820:-1:exon

YOR070C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-21
gene: GYP1
locus tag: YOR070C
gene synonym: YOR29-21
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10508155]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:35134079]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11359917]
experiment: EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:11118206]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:10508155]
note: Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p
codon start: 1
product: GTPase-activating protein GYP1
translation: MGVRSAAKEMHERDHNSDSSSLVTSLMKSWRISSASSSKKPSLYKMNTTESTSLPSGYASSADRDRRTSDGNFEAMAKQQASTRRTSNSYSPLRYVNPTLSTASNESPRPALLLRQHHQRHHHHQQPRHSSSGSVGNNCSNSTEPNKKGDRYFKDLDEDWSAVIDDYNMPIPILTNGGFGTPVAPTRTLSRKSTSSSINSISNMGTSAVRNSSSSFTYPQLPQLQKEKTNDSKKTQLEIENERDVQELNSIIQRISKFDNILKDKTIINQQDLRQISWNGIPKIHRPVVWKLLIGYLPVNTKRQEGFLQRKRKEYRDSLKHTFSDQHSRDIPTWHQIEIDIPRTNPHIPLYQFKSVQNSLQRILYLWAIRHPASGYVQGINDLVTPFFETFLTEYLPPSQIDDVEIKDPSTYMVDEQITDLEADTFWCLTKLLEQITDNYIHGQPGILRQVKNLSQLVKRIDADLYNHFQNEHVEFIQFAFRWMNCLLMREFQMGTVIRMWDTYLSETSQEVTSSYSMSSNDIKPPVTPTEPRVASFVTPTKDFQSPTTALSNMTPNNAVEDSGKMRQSSLNEFHVFVCAAFLIKWSDQLMEMDFQETITFLQNPPTKDWTETDIEMLLSEAFIWQSLYKDATSHWL
SIO_010081: YOR070C
subclass of: SO_0000673
so part of: YOR070C
location: complement(455907..457820)
location: region:455907-457820:-1
so has part: feature:455907-457820:-1:exon

NP_014713.1
type: Protein
SIO_000068: ncbiprotein

S000005596
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455907-457820:-1:exon

YOR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: THI71
alternative label: YOR29-22
gene: NRT1
locus tag: YOR071C
gene synonym: THI71; YOR29-22
so part of: sequence
location: complement(<459480..>461276)
location: region:459480-461276:-1
so has part: feature:459480-461276:-1:exon
subclass of: SO_0000010

854237
type: Gene
SIO_000068: ncbigene

position:459480:-1
position: 459480
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461276:-1
position: 461276
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459480-461276:-1:exon

YOR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: THI71
alternative label: YOR29-22
gene: NRT1
locus tag: YOR071C
gene synonym: THI71; YOR29-22
product: nicotinamide riboside transporter
transcript id: NM_001183490.1
SIO_010081: YOR071C
subclass of: SO_0000673
so part of: YOR071C
location: complement(<459480..>461276)
location: region:459480-461276:-1
so has part: feature:459480-461276:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:459480-461276:-1:exon

YOR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: THI71
alternative label: YOR29-22
gene: NRT1
locus tag: YOR071C
gene synonym: THI71; YOR29-22
experiment: EXISTENCE:genetic interaction:GO:0015888 thiamine transport [PMID:16850348|PMID:9235906]
experiment: EXISTENCE:genetic interaction:GO:0034257 nicotinamide riboside transmembrane transporter activity [PMID:18258590]
experiment: EXISTENCE:genetic interaction:GO:0034258 nicotinamide riboside transport [PMID:18258590]
experiment: EXISTENCE:mutant phenotype:GO:0034257 nicotinamide riboside transmembrane transporter activity [PMID:18258590]
experiment: EXISTENCE:mutant phenotype:GO:0034258 nicotinamide riboside transport [PMID:18258590]
experiment: EXISTENCE:mutant phenotype:GO:1903088 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport [PMID:24778186]
experiment: EXISTENCE:mutant phenotype:GO:1903089 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity [PMID:24778186]
note: High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
codon start: 1
product: nicotinamide riboside transporter
translation: MSFSSIVSKFLRYLEIPAKNRTAVNFLRNPDLQPIKSANQTWGFWSNLAYWGAVSFTAGTWMSGSAALSVGLSYPETIVSFLLGNVLTIIFTMANSYPGYDWKIGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWLGGLSINMILDSWSHHYLHLPNTLSPSVAMTTKQLVGFIIFHVLTALCYFMKPYHMNYLLIWSCVATCFAMLGIVIYLTKNAHGVGELFTSTKSTVTGSKRAWAWVYMISYWFGSISPGSTNQSDYSRFGSSNLAIWTGSVCALLIPATLVPIFGVISASTCDKLYGKQFWMPMDIFDYWLTNNYSAGARAGAFFCGLCFTMSQMSSTISNCGFATGMDMAGLLPKYVDIKRGALFCACISWACLPWNFYNSSSTFLTVMSSFGVVMTPIIAVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMAPGLPGIAWEVNNNYFHDSGIVKFFYGDSFFSFLISFFVYWGLCVFFPFKITVRHDDKDYYGAFTDEEARKKGMIPYSEISEEEIRAYTLGECYTTGHEYKPESSDNESPELIKTSSENTNVFEIVHQKDDEKHSFSTTQQVV
SIO_010081: YOR071C
subclass of: SO_0000673
so part of: YOR071C
location: complement(459480..461276)
location: region:459480-461276:-1
so has part: feature:459480-461276:-1:exon

NP_014714.1
type: Protein
SIO_000068: ncbiprotein

S000005597
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459480-461276:-1:exon

YOR072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-23
locus tag: YOR072W
gene synonym: YOR29-23
so part of: sequence
location: <461502..>461816
location: region:461502-461816:1
so has part: feature:461502-461816:1:exon
subclass of: SO_0000010

854238
type: Gene
SIO_000068: ncbigene

position:461502:1
position: 461502
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461816:1
position: 461816
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:461502-461816:1:exon

YOR072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-23
locus tag: YOR072W
gene synonym: YOR29-23
product: uncharacterized protein
transcript id: NM_001348878.1
SIO_010081: YOR072W
subclass of: SO_0000673
so part of: YOR072W
location: <461502..>461816
location: region:461502-461816:1
so has part: feature:461502-461816:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:461502-461816:1:exon

YOR072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-23
locus tag: YOR072W
gene synonym: YOR29-23
note: hypothetical protein; conserved across S. cerevisiae strains; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
codon start: 1
product: uncharacterized protein
translation: MLTKVVFLFFWSRSDSTKKLAACNHATLAHYILTPALYSDACAIYSDVYSITIIVVATVVRNPARCSLRARKFCRLFSSFFQFHYLKELFYFIRKPDDKFSSFI
SIO_010081: YOR072W
subclass of: SO_0000673
so part of: YOR072W
location: 461502..461816
location: region:461502-461816:1
so has part: feature:461502-461816:1:exon

NP_001335816.1
type: Protein
SIO_000068: ncbiprotein

S000005598
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:461502-461816:1:exon

YNCO0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF11
locus tag: YNCO0017W
so part of: sequence
location: 464450..464551
location: region:464450-464551:1
so has part: feature:464450-464551:1:exon
subclass of: SO_0000663

854239
type: Gene
SIO_000068: ncbigene

position:464450:1
position: 464450
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:464551:1
position: 464551
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464450-464551:1:exon

YNCO0017W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF11
locus tag: YNCO0017W
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin; can mutate to suppress +1 frameshift mutations in proline codons
SIO_010081: YNCO0017W
subclass of: SO_0000673
so part of: YNCO0017W
location: join(464450..464485,464516..464551)
location: region:464450-464551:1
so has part: feature:464450-464485:1:exon
so has part: feature:464516-464551:1:exon

S000006688
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464450-464485:1:exon

position:464485:1
position: 464485
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:464516-464551:1:exon

position:464516:1
position: 464516
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOR072W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR072W-B
so part of: sequence
location: <464469..>464630
location: region:464469-464630:1
so has part: feature:464469-464630:1:exon
subclass of: SO_0000010

1466483
type: Gene
SIO_000068: ncbigene

position:464469:1
position: 464469
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464630:1
position: 464630
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464469-464630:1:exon

YOR072W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR072W-B
product: uncharacterized protein
transcript id: NM_001184526.1
SIO_010081: YOR072W-B
subclass of: SO_0000673
so part of: YOR072W-B
location: <464469..>464630
location: region:464469-464630:1
so has part: feature:464469-464630:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:464469-464630:1:exon

YOR072W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR072W-B
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MILALGDFLTNRKTKHARGPGFNSQLAPFIFDYLFPIGRVTDFFYFFQGPFVL
SIO_010081: YOR072W-B
subclass of: SO_0000673
so part of: YOR072W-B
location: 464469..464630
location: region:464469-464630:1
so has part: feature:464469-464630:1:exon

NP_878171.1
type: Protein
SIO_000068: ncbiprotein

S000028516
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464469-464630:1:exon

YOR073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-24
gene: SGO1
locus tag: YOR073W
gene synonym: YOR29-24
so part of: sequence
location: <464771..>466543
location: region:464771-466543:1
so has part: feature:464771-466543:1:exon
subclass of: SO_0000010

854240
type: Gene
SIO_000068: ncbigene

position:464771:1
position: 464771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:466543:1
position: 466543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464771-466543:1:exon

YOR073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-24
gene: SGO1
locus tag: YOR073W
gene synonym: YOR29-24
product: Sgo1p
transcript id: NM_001183492.1
SIO_010081: YOR073W
subclass of: SO_0000673
so part of: YOR073W
location: <464771..>466543
location: region:464771-466543:1
so has part: feature:464771-466543:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:464771-466543:1:exon

YOR073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-24
gene: SGO1
locus tag: YOR073W
gene synonym: YOR29-24
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:25236599]
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14730319|PMID:15062096]
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:14730319|PMID:16357219|PMID:28980861]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0045184 establishment of protein localization [PMID:25236599]
experiment: EXISTENCE:direct assay:GO:0051383 kinetochore organization [PMID:22365852]
experiment: EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:15637284]
experiment: EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:15637284]
experiment: EXISTENCE:genetic interaction:GO:0034096 positive regulation of maintenance of meiotic sister chromatid cohesion [PMID:15062096]
experiment: EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:14730319|PMID:15062096|PMID:15637284]
experiment: EXISTENCE:mutant phenotype:GO:0000779 condensed chromosome, centromeric region [PMID:28980861]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:15637284]
experiment: EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:17980598|PMID:18081426|PMID:25236599]
experiment: EXISTENCE:mutant phenotype:GO:0034090 maintenance of meiotic sister chromatid cohesion [PMID:14752166]
experiment: EXISTENCE:mutant phenotype:GO:0034096 positive regulation of maintenance of meiotic sister chromatid cohesion [PMID:15062096]
experiment: EXISTENCE:mutant phenotype:GO:0034508 centromere complex assembly [PMID:22365852]
experiment: EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:14730319|PMID:15062096]
experiment: EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:25236599]
experiment: EXISTENCE:mutant phenotype:GO:0051383 kinetochore organization [PMID:22365852]
experiment: EXISTENCE:mutant phenotype:GO:0051757 meiotic sister chromatid separation [PMID:15062096]
experiment: EXISTENCE:mutant phenotype:GO:0070199 establishment of protein localization to chromosome [PMID:24945276]
note: Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension
codon start: 1
product: Sgo1p
translation: MPKRKIAPNKESSRRTVSHDDLTPQIQEFQNLMDLESQKVENIRQSYSRQNSLLAKDNSILKIKVNSLEKKISQLVQENVTLRSKTSISEAIYRERLSNQLQVIENGIIQRFDEIFYMFENVRKNENLPSSSLRTMLKRTSSRSRSCSLSSPTYSKSYTRLSNHENNLSHESSFNKDDGPDLEPKAKKRKSSRRQSMFVSTSLEPEDETGENEPMMENSSVEVPAESHESAQVEETIDALNPEEENSDSVSNFTNSIIEYSIPEENPTEPEHSSSKLEIFNDSTNMLSTVPSNPLPLPLPGPSATLPTTTSDASTVYPSSSSSTNSHPKTKIKHSMKPPRIELKKKVIDEVMPVSNMSSNSEISFTRTRRTRGKAVDYTLPSLRAKMRRPSEKLVDATTVIDIHDLQVSKRNRETSHKRKSLSQDSIPDEPQLREVVVSKDYGTPKGKKTEDEIHEDTAHLMTTSNNNSNNKNEKKLTSNNSPKKSSPLLDITNKSENKKKSTRTKKLFKNAIVNNLSDENSTTRPSKSSKGTSNNNNNYNNFDNNNSNINNVNNKSVSFRLNEDDLAVFDLFGNGKAVKHQPKTYRTKK
SIO_010081: YOR073W
subclass of: SO_0000673
so part of: YOR073W
location: 464771..466543
location: region:464771-466543:1
so has part: feature:464771-466543:1:exon

NP_014716.1
type: Protein
SIO_000068: ncbiprotein

S000005599
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464771-466543:1:exon

YOR074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CRT9
alternative label: TMP1
gene: CDC21
locus tag: YOR074C
gene synonym: CRT9; TMP1
so part of: sequence
location: complement(<466675..>467589)
location: region:466675-467589:-1
so has part: feature:466675-467589:-1:exon
subclass of: SO_0000010

854241
type: Gene
SIO_000068: ncbigene

position:466675:-1
position: 466675
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:467589:-1
position: 467589
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466675-467589:-1:exon

YOR074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CRT9
alternative label: TMP1
gene: CDC21
locus tag: YOR074C
gene synonym: CRT9; TMP1
product: thymidylate synthase
transcript id: NM_001183493.1
SIO_010081: YOR074C
subclass of: SO_0000673
so part of: YOR074C
location: complement(<466675..>467589)
location: region:466675-467589:-1
so has part: feature:466675-467589:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466675-467589:-1:exon

YOR074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CRT9
alternative label: TMP1
gene: CDC21
locus tag: YOR074C
gene synonym: CRT9; TMP1
EC number: 2.1.1.45
experiment: EXISTENCE:direct assay:GO:0004799 thymidylate synthase activity [PMID:6287238]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:8132557]
experiment: EXISTENCE:mutant phenotype:GO:0004799 thymidylate synthase activity [PMID:334734]
experiment: EXISTENCE:mutant phenotype:GO:0006231 dTMP biosynthetic process [PMID:334734|PMID:794696]
note: Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature
codon start: 1
product: thymidylate synthase
translation: MTMDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIILELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKYKTCDDDYTGQGIDQLKQVIHKLKTNPYDRRIIMSAWNPADFDKMALPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDMGLGVPFNIASYALLTRMIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDIDDFKLTDFEIEDYNPHPRIQMKMSV
SIO_010081: YOR074C
subclass of: SO_0000673
so part of: YOR074C
location: complement(466675..467589)
location: region:466675-467589:-1
so has part: feature:466675-467589:-1:exon

NP_014717.2
type: Protein
SIO_000068: ncbiprotein

S000005600
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466675-467589:-1:exon

YOR075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UFE1
locus tag: YOR075W
so part of: sequence
location: <468212..>469252
location: region:468212-469252:1
so has part: feature:468212-469252:1:exon
subclass of: SO_0000010

854242
type: Gene
SIO_000068: ncbigene

position:468212:1
position: 468212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:469252:1
position: 469252
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468212-469252:1:exon

YOR075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UFE1
locus tag: YOR075W
product: Ufe1p
transcript id: NM_001183494.1
SIO_010081: YOR075W
subclass of: SO_0000673
so part of: YOR075W
location: <468212..>469252
location: region:468212-469252:1
so has part: feature:468212-469252:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:468212-469252:1:exon

YOR075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UFE1
locus tag: YOR075W
experiment: EXISTENCE:curator inference:GO:0048279 vesicle fusion with endoplasmic reticulum [PMID:8612273]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8612273|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9214619]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8612273]
experiment: EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:9506516]
note: t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
codon start: 1
product: Ufe1p
translation: MMSDLTPIFRKYVAVIDDARNEQNGIDDHVERKQEDFGNSNETCEMFRDSFIKECARLLKFLVELNKVIKQIEKNYLDDFNMSDAEKDEFDMECRLQIQQYFKKFEFLENYEMERHNLSLKRFQSKSHRWSKILSNKNDNTKHVIHPQDIENGVYEFRLGVLRCLNLWIKYVSSKFTTIQQERLILENKMNFNSTPMPTLSNNADDFSADAIDISVSQSAPVETVQDEVKHYEETISKLTQEQLQVLETEHSELLNQKNEQLKKVETINKTILDIVNIQNELSNHLTVQSQNINLMLNNQDDIELNIKKGNKELRKAKRAAGRTAKMTTYGAIIMGVFILFLDYVG
SIO_010081: YOR075W
subclass of: SO_0000673
so part of: YOR075W
location: 468212..469252
location: region:468212-469252:1
so has part: feature:468212-469252:1:exon

NP_014718.1
type: Protein
SIO_000068: ncbiprotein

S000005601
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468212-469252:1:exon

YOR076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKI7
locus tag: YOR076C
so part of: sequence
location: complement(<469377..>471620)
location: region:469377-471620:-1
so has part: feature:469377-471620:-1:exon
subclass of: SO_0000010

854243
type: Gene
SIO_000068: ncbigene

position:469377:-1
position: 469377
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:471620:-1
position: 471620
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469377-471620:-1:exon

YOR076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKI7
locus tag: YOR076C
product: Ski7p
transcript id: NM_001183495.1
SIO_010081: YOR076C
subclass of: SO_0000673
so part of: YOR076C
location: complement(<469377..>471620)
location: region:469377-471620:-1
so has part: feature:469377-471620:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469377-471620:-1:exon

YOR076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKI7
locus tag: YOR076C
experiment: EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:26051716]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11532933]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:11532933]
experiment: EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:27481473]
experiment: EXISTENCE:genetic interaction:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:11027292]
experiment: EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12769863|PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:27481473]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11532933]
experiment: EXISTENCE:mutant phenotype:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:11027292|PMID:11532933]
experiment: EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]
note: GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication
codon start: 1
product: Ski7p
translation: MSLLEQLARKRIEKSKGLLSADQSHSTSKSASLLERLHKNRETKDNNAETKRKDLKTLLAKDKVKRSDFTPNQHSVSLSLKLSALKKSNSDLEKQGKSVTLDSKENELPTKRKSPDDKLNLEESWKAIKEMNHYCFLKNDPCINQTDDFAFTNFIIKDKKNSLSTSIPLSSQNSSFLSLKKHNNELLGIFVPCNLPKTTRKVAIENFNRPSPDDIIQSAQLNAFNEKLENLNIKSVPKAEKKEPINLQTPPTESIDIHSFIATHPLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGFSMFKKVIQVENDLLPPSSTLTLIDTPGSIKYFNKETLNSILTFDPEVYVLVIDCNYDSWEKSLDGPNNQIYEILKVISYLNKNSACKKHLIILLNKADLISWDKHRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLGSNLNKTENITKSKYKSEFDSINYVPEWYEGPTFFSQLYLLVEHNMNKIETTLEEPFVGTILQSSVLQPIAEINYVSLKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNNISVGLNPDILEVLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLLALRLIKLSIQTHALSDPVDLGSELLLYHNLTHNAVKLVKILGTNDISINPNQSLIVEVEIIEPDFALNVIDSKYITNNIVLTSIDHKVIAVGRIACQ
SIO_010081: YOR076C
subclass of: SO_0000673
so part of: YOR076C
location: complement(469377..471620)
location: region:469377-471620:-1
so has part: feature:469377-471620:-1:exon

NP_014719.1
type: Protein
SIO_000068: ncbiprotein

S000005602
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469377-471620:-1:exon

YOR077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTS2
locus tag: YOR077W
so part of: sequence
location: <471899..>472597
location: region:471899-472597:1
so has part: feature:471899-472597:1:exon
subclass of: SO_0000010

854244
type: Gene
SIO_000068: ncbigene

position:471899:1
position: 471899
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472597:1
position: 472597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:471899-472597:1:exon

YOR077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTS2
locus tag: YOR077W
product: Rts2p
transcript id: NM_001183496.1
SIO_010081: YOR077W
subclass of: SO_0000673
so part of: YOR077W
location: <471899..>472597
location: region:471899-472597:1
so has part: feature:471899-472597:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:471899-472597:1:exon

YOR077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTS2
locus tag: YOR077W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
codon start: 1
product: Rts2p
translation: MADYDSAKYWSKQGARRGLQKTRYYCQICQRQCKDANGFQSHNKSPSHLRKISQVTAEDARRYNIQFEKGFLQLLKQRHGEKWIDANKVYNEYVQDRDHVHMNATMHRSLTQFVRYLGRAGKVDVDMDIDDTSENVEGPLLIRIHPSSLSSPSEDGMLRSQQEEQEVIAAELLKRQLNRAKRQTEKVYQPEMKSEISGDSTLKRVQVTFHGNGRVNKKKKKVPPRKDGIKFR
SIO_010081: YOR077W
subclass of: SO_0000673
so part of: YOR077W
location: 471899..472597
location: region:471899-472597:1
so has part: feature:471899-472597:1:exon

NP_014720.1
type: Protein
SIO_000068: ncbiprotein

S000005603
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:471899-472597:1:exon

YOR078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UTP16
alternative label: YOR29-29
gene: BUD21
locus tag: YOR078W
gene synonym: UTP16; YOR29-29
so part of: sequence
location: <472725..>473369
location: region:472725-473369:1
so has part: feature:472725-473369:1:exon
subclass of: SO_0000010

854245
type: Gene
SIO_000068: ncbigene

position:472725:1
position: 472725
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:473369:1
position: 473369
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472725-473369:1:exon

YOR078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UTP16
alternative label: YOR29-29
gene: BUD21
locus tag: YOR078W
gene synonym: UTP16; YOR29-29
product: Bud21p
transcript id: NM_001183497.1
SIO_010081: YOR078W
subclass of: SO_0000673
so part of: YOR078W
location: <472725..>473369
location: region:472725-473369:1
so has part: feature:472725-473369:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472725-473369:1:exon

YOR078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UTP16
alternative label: YOR29-29
gene: BUD21
locus tag: YOR078W
gene synonym: UTP16; YOR29-29
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309|PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Component of small ribosomal subunit (SSU) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern
codon start: 1
product: Bud21p
translation: MSNGHVKFDADESQASASAVTDRQDDVLVISKKDKEVHSSSDEESDDDDAPQEEGLHSGKSEVESQITQREEAIRLEQSQLRSKRRKQNELYAKQKKSVNETEVTDEVIAELPEELLKNIDQKDEGSTQYSSSRHVTFDKLDESDENEEALAKAIKTKKRKTLKNLRKDSVKRGKFRVQLLSTTQDSKTLPPKKESSIIRSKDRWLNRKALNKG
SIO_010081: YOR078W
subclass of: SO_0000673
so part of: YOR078W
location: 472725..473369
location: region:472725-473369:1
so has part: feature:472725-473369:1:exon

NP_014721.1
type: Protein
SIO_000068: ncbiprotein

S000005604
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472725-473369:1:exon

YOR079C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-30
gene: ATX2
locus tag: YOR079C
gene synonym: YOR29-30
so part of: sequence
location: complement(<473475..>474416)
location: region:473475-474416:-1
so has part: feature:473475-474416:-1:exon
subclass of: SO_0000010

854246
type: Gene
SIO_000068: ncbigene

position:473475:-1
position: 473475
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:474416:-1
position: 474416
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:473475-474416:-1:exon

YOR079C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-30
gene: ATX2
locus tag: YOR079C
gene synonym: YOR29-30
product: Mn(2+) transporter ATX2
transcript id: NM_001183498.1
SIO_010081: YOR079C
subclass of: SO_0000673
so part of: YOR079C
location: complement(<473475..>474416)
location: region:473475-474416:-1
so has part: feature:473475-474416:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:473475-474416:-1:exon

YOR079C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-30
gene: ATX2
locus tag: YOR079C
gene synonym: YOR29-30
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:8887660]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:25713143]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:25713143]
experiment: EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:8887660]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:8887660]
note: Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
codon start: 1
product: Mn(2+) transporter ATX2
translation: MKFLGVILLASFLLIATFLIGLIPLYYIDKQKSSIVTNQEGADSISDFTTNADTQTINDDVSSYRVKIAVLSQFGIGMLLGTSFMLVIPEGIKACVEHDGNVGVNLLIGFLGVYVLDRLVTLWVSRKQTVYTHDAVKFQSWKDIINHPRQIWMNLIQNNVVFALFIHGLSDGIALGTTTNNDSLLIVVLIAIVIHKIPAVLSLTSLMVSRQNLMKWEVICNVFLFASSTPIGYIVLSLLNLSHSPTMDWISGNLLLMSGGSLLYASFTAFVGGDSHDHDLSVEQEVVLPHDESVYVLIGVCIPLVISYCISEE
SIO_010081: YOR079C
subclass of: SO_0000673
so part of: YOR079C
location: complement(473475..474416)
location: region:473475-474416:-1
so has part: feature:473475-474416:-1:exon

NP_014722.1
type: Protein
SIO_000068: ncbiprotein

S000005605
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:473475-474416:-1:exon

YOR080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR29-31
gene: DIA2
locus tag: YOR080W
gene synonym: YOR29-31
so part of: sequence
location: <474594..>476792
location: region:474594-476792:1
so has part: feature:474594-476792:1:exon
subclass of: SO_0000010

854247
type: Gene
SIO_000068: ncbigene

position:474594:1
position: 474594
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:476792:1
position: 476792
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:474594-476792:1:exon

YOR080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR29-31
gene: DIA2
locus tag: YOR080W
gene synonym: YOR29-31
product: DNA-binding SCF ubiquitin ligase subunit DIA2
transcript id: NM_001183499.1
SIO_010081: YOR080W
subclass of: SO_0000673
so part of: YOR080W
location: <474594..>476792
location: region:474594-476792:1
so has part: feature:474594-476792:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:474594-476792:1:exon

YOR080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR29-31
gene: DIA2
locus tag: YOR080W
gene synonym: YOR29-31
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16421250]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:19910927]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19858292]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:16421250]
experiment: EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:19910927]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:19910927]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:11063681]
experiment: EXISTENCE:genetic interaction:GO:0032984 protein-containing complex disassembly [PMID:26255844]
experiment: EXISTENCE:mutant phenotype:GO:0006275 regulation of DNA replication [PMID:16421250]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:23129771]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:15620357|PMID:25342810]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:22844255]
experiment: EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:19910927]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:22844255]
experiment: EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:25342810|PMID:26255844]
note: Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth
codon start: 1
product: DNA-binding SCF ubiquitin ligase subunit DIA2
translation: MSSPGNSGVAIDSTVLKAIELGTRLFKSGEYLQAKRIFTNALRVCDSYSQEQIMRIRNAYQLDTARPDNKRLYHPRYIKILDNICACYEKLNDLKSCLDVSQRLLKLEPGNIKCYIRCTRTLIKLKDWKRAYKTCSRGLQLCNNDSNHLRQQKQFIKNNMVQKQDGKRSYIDPLEETKIAKKKKNNNVLESLPKKKIKGSTKKTDLVGNLPIEILPIIFQRFTTKELVTLSLVCNKWRDKILYHLDCFQEFNLAPINFKNFVKFMDFLQQNFTRTYRKYILSQVKVSSRITSEELRITQLLFSKMPKCINIERLILSMPTLTTTQIFKLMVRGGTDFFTRLLELSLMITYRPDKQHELEILQTCPLLKKIELIFVNSLVPIFDGNNSVGRDGSFNVMARHTNMQISTADNDEQGIVEEKVIYSELEKITLICDKKKIKNFPLCRALLRGQFPLLQKLTITGVTFPMNNQDIMNFQWLLNFPDLKELWIEDNDNCELSKFLQLLKFSNVWKNLEKLTFRENKLYPIVNLDEDQPVTNDDEVPSMLFYKENLQNLEKLDLMGTSISGSALTRLCEQEYLDGRKLRSLNIGNCPNIQFPNNHAHTARMILDVNAVLKRLSKLEEINLSHLSSLNDSTMKSFIINVPFLENLKRLDISHNFEITGISIYEFLKKFQMDHDNEAGGQPLAYLNIDGCSQVSHITVNMIRAQNLVTQVDCVYERDVWRKFGINSYSYS
SIO_010081: YOR080W
subclass of: SO_0000673
so part of: YOR080W
location: 474594..476792
location: region:474594-476792:1
so has part: feature:474594-476792:1:exon

NP_014723.2
type: Protein
SIO_000068: ncbiprotein

S000005606
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:474594-476792:1:exon

YOR081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: STC2
gene: TGL5
locus tag: YOR081C
gene synonym: STC2
so part of: sequence
location: complement(<476939..>479188)
location: region:476939-479188:-1
so has part: feature:476939-479188:-1:exon
subclass of: SO_0000010

854248
type: Gene
SIO_000068: ncbigene

position:476939:-1
position: 476939
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:479188:-1
position: 479188
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476939-479188:-1:exon

YOR081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: STC2
gene: TGL5
locus tag: YOR081C
gene synonym: STC2
product: triacylglycerol lipase
transcript id: NM_001183500.1
SIO_010081: YOR081C
subclass of: SO_0000673
so part of: YOR081C
location: complement(<476939..>479188)
location: region:476939-479188:-1
so has part: feature:476939-479188:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476939-479188:-1:exon

YOR081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: STC2
gene: TGL5
locus tag: YOR081C
gene synonym: STC2
EC number: 3.1.1.3
experiment: EXISTENCE:direct assay:GO:0004806 triglyceride lipase activity [PMID:16135509]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:16135509|PMID:24868093|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006642 triglyceride mobilization [PMID:16135509]
experiment: EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:20016004]
experiment: EXISTENCE:mutant phenotype:GO:0004806 triglyceride lipase activity [PMID:16135509]
experiment: EXISTENCE:mutant phenotype:GO:0006642 triglyceride mobilization [PMID:16135509]
note: Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication
codon start: 1
product: triacylglycerol lipase
translation: MSNTLPVTEFLLSKYYELSNTPATDSSSLFKWLYHKTLSRKQLLISDLSSQKKHAISYDQWNDIASRLDDLTGLSEWKTIDESSLYNYKLLQDLTIRMRHLRTTHDYHRLLYLIRTKWVRNLGNMNNVNLYRHSHTGTKQIIHDYLEESQAVLTALIHQSNMNDHYLLGILQQTRRNIGRTALVLSGGSTFGLFHIGVLAALFESDLMPKVISGSSAGAIVASIFCVHTTQEIPSLLTNVLNMEFNIFNDDNSKSPNENLLIKISRFCQNGTWFNNQPLINTMLSFLGNLTFREAYNKTGKILNITVSPASIYEQPKLLNNLTAPNVLIWSAVCASCSLPGVFPSTPLFEKDPHTGKIKEWGATNLHLSNMKFMDGSVDNDMPISRLSEMFNVDHIIACQVNIHVFPLLKFSNTCVGGEIEKEITARFRNQVTKIFKFFSDETIHFLDILKELEFHPYLMTKLKHLFLQQYSGNVTILPDLSMVGQFHEVLKNPSQLFLLHQTTLGARATWPKISMIQNNCGQEFALDKAITFLKEKIIISSSIKNPLQFYQPRFSEQIKSLSIMDADLPGVDLEESSSNSLSIIKSPNKTAAPGRFPLQPLPSPSSTFNKRKMDMLSPSPSPSTSPQRSKSSFTQQGTRQKANSLSFAIGASSLRLKKSPLKVPSRPQFKKRSSYYNQNMSAEMRKNRKKSGTISSYDVQTNSEDFPIPAIENGSFDNTLFNPSRFPMDAMSAATNDNFMNNSDIFQN
SIO_010081: YOR081C
subclass of: SO_0000673
so part of: YOR081C
location: complement(476939..479188)
location: region:476939-479188:-1
so has part: feature:476939-479188:-1:exon

NP_014724.1
type: Protein
SIO_000068: ncbiprotein

S000005607
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476939-479188:-1:exon

YOR083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WHI5
locus tag: YOR083W
so part of: sequence
location: <479533..>480420
location: region:479533-480420:1
so has part: feature:479533-480420:1:exon
subclass of: SO_0000010

854249
type: Gene
SIO_000068: ncbigene

position:479533:1
position: 479533
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:480420:1
position: 480420
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:479533-480420:1:exon

YOR083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WHI5
locus tag: YOR083W
product: transcriptional repressor WHI5
transcript id: NM_001183502.1
SIO_010081: YOR083W
subclass of: SO_0000673
so part of: YOR083W
location: <479533..>480420
location: region:479533-480420:1
so has part: feature:479533-480420:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:479533-480420:1:exon

YOR083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WHI5
locus tag: YOR083W
experiment: EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:15210111]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210111|PMID:24470217|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15210111|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:15210110]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:15210111]
experiment: EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:19745812]
experiment: EXISTENCE:genetic interaction:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:15210110|PMID:15210111|PMID:19823668]
experiment: EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:19745812]
experiment: EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:26390151]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:15210110|PMID:15210111]
note: Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; WHI5 expression is repressed in M/early G phase; phosphorylation of Whi5p by G1 cyclin (Cln)/Cdc28p relieves repression and promoter binding by Whi5p, drives nuclear export, and contributes to both the determination of critical cell size at START and cell fate; dephosphorylated and re-imported into the nucleus post-START during the starvation response, reversing commitment
codon start: 1
product: transcriptional repressor WHI5
translation: MSLRTPKRSRTSDEQEQEQEQEQVQNPDTHVNNEHQQRPGPTTLLSTPVRLKNGFGTPSPPSPPGITKSITKSRRRPSTTSLQGIFMSPVNKRRVGITAHGRVYDHNDDGHESESEDDENEEENENQKKYDGHVSMPLLPPTTPKSRRSEVFLSPSPRLRSPPTAARRSTGERPIREISHTLRTRLNYALVKLQNGWTDKTLPELETELAPAVQTPPRRYHNRFPDSADAGTSAHTAFLQALGGHPPREEATAVETLMLLSSPTKKQQHRPVPATSAGEPTDETEPESDTEVETS
SIO_010081: YOR083W
subclass of: SO_0000673
so part of: YOR083W
location: 479533..480420
location: region:479533-480420:1
so has part: feature:479533-480420:1:exon

NP_014726.1
type: Protein
SIO_000068: ncbiprotein

S000005609
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:479533-480420:1:exon

YOR084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LPX1
locus tag: YOR084W
so part of: sequence
location: <480587..>481750
location: region:480587-481750:1
so has part: feature:480587-481750:1:exon
subclass of: SO_0000010

854251
type: Gene
SIO_000068: ncbigene

position:480587:1
position: 480587
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:481750:1
position: 481750
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:480587-481750:1:exon

YOR084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LPX1
locus tag: YOR084W
product: triglyceride lipase
transcript id: NM_001183503.1
SIO_010081: YOR084W
subclass of: SO_0000673
so part of: YOR084W
location: <480587..>481750
location: region:480587-481750:1
so has part: feature:480587-481750:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:480587-481750:1:exon

YOR084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LPX1
locus tag: YOR084W
experiment: EXISTENCE:direct assay:GO:0004806 triglyceride lipase activity [PMID:24187129]
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:12135984]
experiment: EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:24187129]
note: Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible
codon start: 1
product: triglyceride lipase
translation: MEQNRFKKETKTCSASWPRAPQSTLCATDRLELTYDVYTSAERQRRSRTATRLNLVFLHGSGMSKVVWEYYLPRLVAADAEGNYAIDKVLLIDQVNHGDSAVRNRGRLGTNFNWIDGARDVLKIATCELGSIDSHPALNVVIGHSMGGFQALACDVLQPNLFHLLILIEPVVITRKAIGAGRPGLPPDSPQIPENLYNSLRLKTCDHFANESEYVKYMRNGSFFTNAHSQILQNIIDFERTKASGDDEDGGPVRTKMEQAQNLLCYMNMQTFAPFLISNVKFVRKRTIHIVGARSNWCPPQNQLFLQKTLQNYHLDVIPGGSHLVNVEAPDLVIERINHHIHEFVLTSPLQSSHIPQLTLEERAVMFDRAFDSFKNEALVKTTKQKL
SIO_010081: YOR084W
subclass of: SO_0000673
so part of: YOR084W
location: 480587..481750
location: region:480587-481750:1
so has part: feature:480587-481750:1:exon

NP_014727.1
type: Protein
SIO_000068: ncbiprotein

S000005610
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:480587-481750:1:exon

YOR085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OST3
locus tag: YOR085W
so part of: sequence
location: <482033..>483085
location: region:482033-483085:1
so has part: feature:482033-483085:1:exon
subclass of: SO_0000010

854252
type: Gene
SIO_000068: ncbigene

position:482033:1
position: 482033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483085:1
position: 483085
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482033-483085:1:exon

YOR085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OST3
locus tag: YOR085W
product: dolichyl-diphosphooligosaccharide--protein glycotransferase OST3
transcript id: NM_001183504.1
SIO_010081: YOR085W
subclass of: SO_0000673
so part of: YOR085W
location: <482033..>483085
location: region:482033-483085:1
so has part: feature:482033-483085:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482033-483085:1:exon

YOR085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OST3
locus tag: YOR085W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:23416356]
experiment: EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:10358084]
experiment: EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:22492205]
experiment: EXISTENCE:genetic interaction:GO:0065003 protein-containing complex assembly [PMID:10358084]
experiment: EXISTENCE:mutant phenotype:GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity [PMID:7622558]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:7622558]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:28598353]
experiment: EXISTENCE:mutant phenotype:GO:0016020 membrane [PMID:7622558]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins including modification of Pmt2p at N131 and N403
codon start: 1
product: dolichyl-diphosphooligosaccharide--protein glycotransferase OST3
translation: MNWLFLVSLVFFCGVSTHPALAMSSNRLLKLANKSPKKIIPLKDSSFENILAPPHENAYIVALFTATAPEIGCSLCLELESEYDTIVASWFDDHPDAKSSNSDTSIFFTKVNLEDPSKTIPKAFQFFQLNNVPRLFIFKPNSPSILDHSVISISTDTGSERMKQIIQAIKQFSQVNDFSLHLPMDWTPIITSTIITFITVLLFKKQSKLMFSIISSRIIWATLSTFFIICMISAYMFNQIRNTQLAGVGPKGEVMYFLPNEFQHQFAIETQVMVLIYGTLAALVVVLVKGIQFLRSHLYPETKKAYFIDAILASFCALFIYVFFAALTTVFTIKSPAYPFPLLRLSAPFK
SIO_010081: YOR085W
subclass of: SO_0000673
so part of: YOR085W
location: 482033..483085
location: region:482033-483085:1
so has part: feature:482033-483085:1:exon

NP_014728.1
type: Protein
SIO_000068: ncbiprotein

S000005611
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482033-483085:1:exon

YOR086C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCB1
locus tag: YOR086C
so part of: sequence
location: complement(<483219..>486779)
location: region:483219-486779:-1
so has part: feature:483219-486779:-1:exon
subclass of: SO_0000010

854253
type: Gene
SIO_000068: ncbigene

position:483219:-1
position: 483219
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486779:-1
position: 486779
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483219-486779:-1:exon

YOR086C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCB1
locus tag: YOR086C
product: tricalbin
transcript id: NM_001183505.1
SIO_010081: YOR086C
subclass of: SO_0000673
so part of: YOR086C
location: complement(<483219..>486779)
location: region:483219-486779:-1
so has part: feature:483219-486779:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483219-486779:-1:exon

YOR086C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCB1
locus tag: YOR086C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:15049706]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22250200]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]
experiment: EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]
experiment: EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]
note: Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of the Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER and to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
codon start: 1
product: tricalbin
translation: MAKEDTGVTAPKKPETAQVANINGIDKLEPPKTKEETESSKSVSSEKAAHASDESFKRSIHEASYVGWKQIGGWEDKDELTLDDELMDMTRETFLDNIIPDSLYGDWYHSVAIFFIGGVASFALGHYKFSMGSAFFVIVITSLLYRTSAKKYRGSIRELVQKEFTVQKVENDYESLEWLNAFLDKYWPILEPSVSQLIVQQANEQMATNEAIPKFITQLWIDELTLGVKPPRVDLVKTFQNTASDVVVMDWGISFTPHDLCDMSAKQVRNYVNELAVVKAKIFGITIPVSVSDIAFKAHARVKFKLMTPFPHVETVNIQLLKVPDFDFVATLFGRSIFNWEILAIPGLMTLIQKMAKKYMGPILLPPFSLQLNIPQLLSGSNLSIGILEITVKNAKGLKRTSSILNESIDPYLSFEFNDISIAKTRTVRDTLNPVWDETLYVLLNSFTDPLTISVYDKRAKLKDKVLGRIQYNLNTLHDKTTQRNLKAQFLRNSKPVGELTFDLRFFPTLEEKKLPDGSVEELPDLNTGIAKVVVEEGSRFAEEEQKVTAYVEVYLNAKLVLTTGKATDTGTLKWNSDYEAVIADRRKTRYKFVVKDGKGEEIGSTIQTLNDLIDRSQVNKNLIPLKNQKGDIKITTYWRPVRLEIGSNSVAYTPPIGAIRVFIEKANDLRNLEKFGTIDPYCKVLVNGLSKGRTDFKSQTLNPVWNQVIYVAVTSPNQRITLQCMDVETVNKDRSLGEFNVNVQDLFKKDENDKYEETIDEKAKVGRLVMPKKKPKGTITYYTSFYPALPVLTLEEIQDLDKVNKKKKALELRKSAIDEKKISKEDKAKFDQEWNEVKELEDMYSNRQKLDLPELLQYNQGVLAVTVLNGELPDSGLYVQAFFDDNGHPRFVSPRIPSRIVKNGWSGDVIIKELDKSITTFRVAKNKNYNRVEKCVCEVELPTQELVKNCYYKPSILHLSGEGSAKLMLQISWFPIDTKQLPANDLITNSGDLTIMSRSAENLIASDLNGYSDPYLKYYINNEEDCAYKTKVVKKTLNPKWNDEGTIQINNRLNDVLRIKVMDWDSTSADDTIGTAEIPLNKVKVEGTTELDVPVEGLENAGQDGGMLHLAFSFKPRYTISVSKREKKVGDIASKGLGTGLKAGTTVIGGGVGAIGKIKKGVFGGLGSLTNHKKNHEMGEEETKF
SIO_010081: YOR086C
subclass of: SO_0000673
so part of: YOR086C
location: complement(483219..486779)
location: region:483219-486779:-1
so has part: feature:483219-486779:-1:exon

NP_014729.1
type: Protein
SIO_000068: ncbiprotein

S000005612
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483219-486779:-1:exon

YNCO0018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0018W
so part of: sequence
location: 487439..487512
location: region:487439-487512:1
so has part: feature:487439-487512:1:exon
subclass of: SO_0000663

854254
type: Gene
SIO_000068: ncbigene

position:487439:1
position: 487439
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:487512:1
position: 487512
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487439-487512:1:exon

YNCO0018W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0018W
product: tRNA-Asn
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0018W
subclass of: SO_0000673
so part of: YNCO0018W
location: 487439..487512
location: region:487439-487512:1
so has part: feature:487439-487512:1:exon

S000006676
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:487439-487512:1:exon

YOR087W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR088W
gene: YVC1
locus tag: YOR087W
gene synonym: YOR088W
so part of: sequence
location: <487707..>489734
location: region:487707-489734:1
so has part: feature:487707-489734:1:exon
subclass of: SO_0000010

854255
type: Gene
SIO_000068: ncbigene

position:487707:1
position: 487707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:489734:1
position: 489734
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487707-489734:1:exon

YOR087W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR088W
gene: YVC1
locus tag: YOR087W
gene synonym: YOR088W
product: Yvc1p
transcript id: NM_001183506.1
SIO_010081: YOR087W
subclass of: SO_0000673
so part of: YOR087W
location: <487707..>489734
location: region:487707-489734:1
so has part: feature:487707-489734:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:487707-489734:1:exon

YOR087W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR088W
gene: YVC1
locus tag: YOR087W
gene synonym: YOR088W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11427713|PMID:11781332]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20035756|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005227 calcium activated cation channel activity [PMID:1700419]
experiment: EXISTENCE:direct assay:GO:0005244 voltage-gated ion channel activity [PMID:1700419]
experiment: EXISTENCE:direct assay:GO:0005262 calcium channel activity [PMID:11781332]
experiment: EXISTENCE:direct assay:GO:0005267 potassium channel activity [PMID:1700419]
experiment: EXISTENCE:direct assay:GO:0005272 sodium channel activity [PMID:1700419]
experiment: EXISTENCE:direct assay:GO:0030003 cellular cation homeostasis [PMID:11427713|PMID:11781332]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]
experiment: EXISTENCE:mutant phenotype:GO:0030003 cellular cation homeostasis [PMID:11427713|PMID:11781332]
experiment: EXISTENCE:mutant phenotype:GO:0097553 calcium ion transmembrane import into cytosol [PMID:27708136]
note: Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
codon start: 1
product: Yvc1p
translation: MVSANGDLHLPISNEQCMPENNGSLGFEAPTPRQILRVTLNLKYLIDKVVPIVYDPNDIVCDHSEILSPKVVKLAYEACGGNPKDKANKRKYQSVIIFSLLKVCEWYSILATMEVHNAKLYETRNLASQQLCKLLIEREETRDLQFLFMQLLLRRYVINENDEDQEPLNALELATDMHCTTVIGSSGFQRCLKWIWRGWIVQNGLDPTTFIKDDSLAEVSLISHFNPVRLKAPVYQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAHLSFWNLFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKISYRVLSCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGPILGNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIRAPDEDVYVSPLNLIEVFMTPIFRILPPKRAKDLSYTVMTIVYSPFLLLISVKETREARRIKYNRMKRLNDDANEYDTPWDLTDGYLDDDDGLFSDNRNSGMRATQLKNSRSLKLQRTAEQEDVHFKVPKKWYKNVKKCSPSFEQYDNDDTEDDAGEDKDEVKELTKKVENLTAVITDLLEKLDIKDKKE
SIO_010081: YOR087W
subclass of: SO_0000673
so part of: YOR087W
location: 487707..489734
location: region:487707-489734:1
so has part: feature:487707-489734:1:exon

NP_014730.2
type: Protein
SIO_000068: ncbiprotein

S000005613
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:487707-489734:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1501; Autonomously Replicating Sequence
so part of: sequence
location: 489683..489942
location: region:489683-489942:1
so has part: feature:489683-489942:1:region

S000007554
type: SGD
SIO_000068: sgd

position:489683:1
position: 489683
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:489942:1
position: 489942
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:489683-489942:1:region

YOR089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VPS12
alternative label: VPT12
alternative label: YPT21
alternative label: YPT51
gene: VPS21
locus tag: YOR089C
gene synonym: VPS12; VPT12; YPT21; YPT51
so part of: sequence
location: complement(<490196..>490828)
location: region:490196-490828:-1
so has part: feature:490196-490828:-1:exon
subclass of: SO_0000010

854256
type: Gene
SIO_000068: ncbigene

position:490196:-1
position: 490196
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490828:-1
position: 490828
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490196-490828:-1:exon

YOR089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VPS12
alternative label: VPT12
alternative label: YPT21
alternative label: YPT51
gene: VPS21
locus tag: YOR089C
gene synonym: VPS12; VPT12; YPT21; YPT51
product: Rab family GTPase VPS21
transcript id: NM_001183508.1
SIO_010081: YOR089C
subclass of: SO_0000673
so part of: YOR089C
location: complement(<490196..>490828)
location: region:490196-490828:-1
so has part: feature:490196-490828:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490196-490828:-1:exon

YOR089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VPS12
alternative label: VPT12
alternative label: YPT21
alternative label: YPT51
gene: VPS21
locus tag: YOR089C
gene synonym: VPS12; VPT12; YPT21; YPT51
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005769 early endosome [PMID:31754649]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:22748138|PMID:23612966]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22748138]
experiment: EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]
experiment: EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:22748138]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:22748138|PMID:23612966]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]
note: Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
codon start: 1
product: Rab family GTPase VPS21
translation: MNTSVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTINEHTVKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSFIKARHWVKELHEQASKDIIIALVGNKIDMLQEGGERKVAREEGEKLAEEKGLLFFETSAKTGENVNDVFLGIGEKIPLKTAEEQNSASNERESNNQRVDLNAANDGTSANSACSC
SIO_010081: YOR089C
subclass of: SO_0000673
so part of: YOR089C
location: complement(490196..490828)
location: region:490196-490828:-1
so has part: feature:490196-490828:-1:exon

NP_014732.1
type: Protein
SIO_000068: ncbiprotein

S000005615
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490196-490828:-1:exon

YOR090C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPP1
gene: PTC5
locus tag: YOR090C
gene synonym: PPP1
so part of: sequence
location: complement(<491123..>492841)
location: region:491123-492841:-1
so has part: feature:491123-492841:-1:exon
subclass of: SO_0000010

854257
type: Gene
SIO_000068: ncbigene

position:491123:-1
position: 491123
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:492841:-1
position: 492841
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491123-492841:-1:exon

YOR090C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPP1
gene: PTC5
locus tag: YOR090C
gene synonym: PPP1
product: type 2C protein phosphatase PTC5
transcript id: NM_001183509.1
SIO_010081: YOR090C
subclass of: SO_0000673
so part of: YOR090C
location: complement(<491123..>492841)
location: region:491123-492841:-1
so has part: feature:491123-492841:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491123-492841:-1:exon

YOR090C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPP1
gene: PTC5
locus tag: YOR090C
gene synonym: PPP1
EC number: 3.1.3.43
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10580002]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16643908|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:32398688]
experiment: EXISTENCE:mutant phenotype:GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity [PMID:18180296]
experiment: EXISTENCE:mutant phenotype:GO:0070262 peptidyl-serine dephosphorylation [PMID:18180296]
experiment: EXISTENCE:mutant phenotype:GO:1904184 positive regulation of pyruvate dehydrogenase activity [PMID:16643908|PMID:18180296]
note: Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
codon start: 1
product: type 2C protein phosphatase PTC5
translation: MSPLTRTVAIKKTVKVLSKCQSGREYTQKFLQRAYSTSHANSTYYSRTKLFISSHSKALNIALLSGSLLLTYSYYSPKKILSLDTINGIKDYSTNTSGNINMPSPNPKGTETQKSQRSQNDQSVLILNDSKIEAKLHDREESHFVNRGTGIFRYDVAQLPSNHPIEDDHVEQIITIPIESEDGKSIEKDLYFFGIFDGHGGPFTSEKLSKDLVRYVAYQLGQVYDQNKTVFHSDPNQLIDSAISKGFLKLDNDLVIESFRKLFQDPNNTNIANTLPAISGSCALLSLYNSTNSILKVAVTGDSRALICGLDNEGNWTVKSLSTDQTGDNLDEVRRIRKEHPGEPNVIRNGRILGSLQPSRAFGDYRYKIKEVDGKPLSDLPEVAKLYFRREPRDFKTPPYVTAEPVITSAKIGENTKFMVMGSDGLFELLTNEEIASLVIRWMDKNMNLAPVKAEPGKLPKVIDVSEDKEAQRPAFRYKDNNSSSPSGSNPEYLIEDKNVATHLIRNALSAGGRKEYVSALVSIPSPMSRRYRDDLTVTVAFFGDSGTPSIVSNATSIVMNPEATTKPKPRL
SIO_010081: YOR090C
subclass of: SO_0000673
so part of: YOR090C
location: complement(491123..492841)
location: region:491123-492841:-1
so has part: feature:491123-492841:-1:exon

NP_014733.1
type: Protein
SIO_000068: ncbiprotein

S000005616
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491123-492841:-1:exon

YOR091W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TMA46
locus tag: YOR091W
so part of: sequence
location: <493433..>494470
location: region:493433-494470:1
so has part: feature:493433-494470:1:exon
subclass of: SO_0000010

854258
type: Gene
SIO_000068: ncbigene

position:493433:1
position: 493433
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:494470:1
position: 494470
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:493433-494470:1:exon

YOR091W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TMA46
locus tag: YOR091W
product: Tma46p
transcript id: NM_001183510.1
SIO_010081: YOR091W
subclass of: SO_0000673
so part of: YOR091W
location: <493433..>494470
location: region:493433-494470:1
so has part: feature:493433-494470:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:493433-494470:1:exon

YOR091W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TMA46
locus tag: YOR091W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]
experiment: EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]
note: hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p
codon start: 1
product: Tma46p
translation: MPPKKGKQAQAAGKKKDNVDKTFGMKNKNRSTKVQKYIKQVQSQSDPKKEEMRLKKLEEKKRREAEEAERRALFNPVADQRVRAGVDPKSMVCALFKLGNCNKGAKCKFSHDLNVGRRMEKKDLYQDTRSEKENDTMDNWDEEKLRKVILSKHGNPKTTTDKVCKYFIEAVENGKYGWFWICPNGGDKCMYRHSLPEGFVLKTNEQKRLERESLEKQPKITLEEFIETERGKLDKSKLTPITIANFAQWKKDHVIAKINAEKKLSSKRKPTGREIILKMSAENKSFETDNADMPDDVTQGSAWDLTEFTDALKKADHQDDGGIKDYGDGSNPTFDIKKANSATLA
SIO_010081: YOR091W
subclass of: SO_0000673
so part of: YOR091W
location: 493433..494470
location: region:493433-494470:1
so has part: feature:493433-494470:1:exon

NP_014734.2
type: Protein
SIO_000068: ncbiprotein

S000005617
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:493433-494470:1:exon

YOR092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YOR3165W
gene: ECM3
locus tag: YOR092W
gene synonym: YOR3165W
so part of: sequence
location: <495127..>496968
location: region:495127-496968:1
so has part: feature:495127-496968:1:exon
subclass of: SO_0000010

854259
type: Gene
SIO_000068: ncbigene

position:495127:1
position: 495127
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:496968:1
position: 496968
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:495127-496968:1:exon

YOR092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YOR3165W
gene: ECM3
locus tag: YOR092W
gene synonym: YOR3165W
product: putative ATPase ECM3
transcript id: NM_001183511.1
SIO_010081: YOR092W
subclass of: SO_0000673
so part of: YOR092W
location: <495127..>496968
location: region:495127-496968:1
so has part: feature:495127-496968:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:495127-496968:1:exon

YOR092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YOR3165W
gene: ECM3
locus tag: YOR092W
gene synonym: YOR3165W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:22842922|PMID:26928762]
note: Non-essential hypothetical protein; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
codon start: 1
product: putative ATPase ECM3
translation: MTHITLGQAIWASVRPIIKIYLIIGVGFGLCKMNILTVQATRSISDIVLTILLPCLSFNKIVANIEDNDIKDVGIICLTSVILFATGLGFAFIVRSVLPVPKRWRGGILAGGMFPNISDLPIAYLQSMDQGFIFTEAEGEKGVANVIIFLAMFLICVFNLGGFRLIENDFHYKGDDDEENTLTNDDSAQQPTQPIEGNSSSSSNQDILKEPNESTVPNSSQASYISEKNKKEKTELSVPKPTHTAPPAIDDRSSNSSAVVSIDSITHSLRTNHVDAQSVSELNDPTYRTRSQPIAYTTESRTSHVHNNRRNSITGSLRSIDMRELPAEGMSDLIREYSNVDQYGRRRKSSISSQGAPSVLQADGTISPNLTRTSTLQRVKTSNLTRIITSDATVSKKDIETSGSSLPKWLQKFPLTKFFVFFLKNCLRPCSMAVILALIIAFIPWVKALFVTTSNTPKIKQAPDNAPALTFIMDFTSYVGAASVPFGLILLGATLGRLKIGKLYPGFWKSAVVLVFLRQCIMPIFGVLWCDRLVKAGWLNWENDKMLLFVTAITWNLPTMTTLIYFTASYTPEDETEPVQMECTSFFLMLQYPLMVVSLPFLVSYFIKVQMKL
SIO_010081: YOR092W
subclass of: SO_0000673
so part of: YOR092W
location: 495127..496968
location: region:495127-496968:1
so has part: feature:495127-496968:1:exon

NP_014735.1
type: Protein
SIO_000068: ncbiprotein

S000005618
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:495127-496968:1:exon

YOR093C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DIP2
gene: CMR2
locus tag: YOR093C
gene synonym: DIP2
so part of: sequence
location: complement(<497506..>502452)
location: region:497506-502452:-1
so has part: feature:497506-502452:-1:exon
subclass of: SO_0000010

854260
type: Gene
SIO_000068: ncbigene

position:497506:-1
position: 497506
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502452:-1
position: 502452
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497506-502452:-1:exon

YOR093C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DIP2
gene: CMR2
locus tag: YOR093C
gene synonym: DIP2
product: Cmr2p
transcript id: NM_001183512.1
SIO_010081: YOR093C
subclass of: SO_0000673
so part of: YOR093C
location: complement(<497506..>502452)
location: region:497506-502452:-1
so has part: feature:497506-502452:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:497506-502452:-1:exon

YOR093C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DIP2
gene: CMR2
locus tag: YOR093C
gene synonym: DIP2
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:35766356]
experiment: EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:35766356]
experiment: EXISTENCE:mutant phenotype:GO:0046339 diacylglycerol metabolic process [PMID:35766356]
experiment: EXISTENCE:mutant phenotype:GO:0097576 vacuole fusion [PMID:35766356]
note: Protein involved in regulation of diacylglycerol lipids levels; deletion causes sensitivity to unfolded protein response-inducing agents
codon start: 1
product: Cmr2p
translation: MDFSIPPTLPLDLQSRLNELIQDYKDENLTRKGYETKRKQLLDKFEISQMRPYTPLRSPNSRKSKHLHRRNTSLASSITSLPNSIDRRHSIYRVTTINSTSANNTPRRRSKRYTASLQSSLPGSSDENGSVKDAVYNPMIPLLPRHTGAENTSSGDSAMTDSLPLILRGRFEHYDGQTAMISINSKGKETFITWDKLYLKAERVAHELNKSHLYKMDKILLWYNKNDVIEFTIALLGCFISGMAAVPVSFETYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTKAKKTSPTFDIPNISYIEFTRTPLGRLSGVVMKHNILINQFETMTKILNSRSMPHWKQKSQSIRKPFHKKIMATNSRFVILNSLDPTRSTGLIMGVLFNLFTGNLMISIDSSILQRPGGYENIIDKFRADILLNDQLQLKQVVINYLENPESAFSKKHKIDFSCIKSCLTSCTTIDTDVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFINREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISSNHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTKLMGFVHNGKIYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAESTKAIDISSLSGETSSGYKRVVESHYLQQITETVVRTVNTVFEVAAFELQHHKEEHFLVMVVESSLAKTEEESKNGETTDTTLMKFAETQRNKLETKMNDLTDQIFRILWIFHKIQPMCILVVPRDTLPRRYCSLELANSTVEKKFLNNDLSAQFVKFQFDNVILDFLPHSAYYNESILSEHLSKLRKMALQEEYAMIEPAYRNGGPVKPKLALQCSGVDYRDESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNASKIVKETLQLRNNSPLFSICSHTSGLGFMFSCLLGIYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTKGISPKNSSMIMEVWAKNRASIMQAWFDQKIQIEAQFGINYGENISIYLLSDYEKDNI
SIO_010081: YOR093C
subclass of: SO_0000673
so part of: YOR093C
location: complement(497506..502452)
location: region:497506-502452:-1
so has part: feature:497506-502452:-1:exon

NP_014736.1
type: Protein
SIO_000068: ncbiprotein

S000005619
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:497506-502452:-1:exon

YOR094W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARL2
gene: ARF3
locus tag: YOR094W
gene synonym: ARL2
so part of: sequence
location: <502795..>503346
location: region:502795-503346:1
so has part: feature:502795-503346:1:exon
subclass of: SO_0000010

854261
type: Gene
SIO_000068: ncbigene

position:502795:1
position: 502795
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:503346:1
position: 503346
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:502795-503346:1:exon

YOR094W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARL2
gene: ARF3
locus tag: YOR094W
gene synonym: ARL2
product: Arf family GTPase ARF3
transcript id: NM_001183513.1
SIO_010081: YOR094W
subclass of: SO_0000673
so part of: YOR094W
location: <502795..>503346
location: region:502795-503346:1
so has part: feature:502795-503346:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:502795-503346:1:exon

YOR094W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARL2
gene: ARF3
locus tag: YOR094W
gene synonym: ARL2
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8063710]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17786213]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17786213]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:18208507]
experiment: EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:17425670]
experiment: EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:14668359|PMID:17425670]
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:12972567]
experiment: EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:8063710]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:18208507]
experiment: EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:23783029]
experiment: EXISTENCE:mutant phenotype:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:18208507]
experiment: EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:23783029]
experiment: EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18397879]
note: Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6
codon start: 1
product: Arf family GTPase ARF3
translation: MGNSISKVLGKLFGSKEMKILMLGLDKAGKTTILYKLKLNKIKTSTPTVGFNVETVTYKNVKFNMWDVGGQQRLRPLWRHYFPATTALIFVIDSSARNRMEEAKEELYSIIGEKEMENVVLLVWANKQDLKDAMKPQEVSDFLELEKNLKNQPWCVIGSNALSGQGLVEGLSWISNNTNVPKK
SIO_010081: YOR094W
subclass of: SO_0000673
so part of: YOR094W
location: 502795..503346
location: region:502795-503346:1
so has part: feature:502795-503346:1:exon

NP_014737.1
type: Protein
SIO_000068: ncbiprotein

S000005620
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:502795-503346:1:exon

YOR095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RKI1
locus tag: YOR095C
so part of: sequence
location: complement(<503552..>504328)
location: region:503552-504328:-1
so has part: feature:503552-504328:-1:exon
subclass of: SO_0000010

854262
type: Gene
SIO_000068: ncbigene

position:503552:-1
position: 503552
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:504328:-1
position: 504328
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503552-504328:-1:exon

YOR095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RKI1
locus tag: YOR095C
product: ribose-5-phosphate isomerase RKI1
transcript id: NM_001183514.1
SIO_010081: YOR095C
subclass of: SO_0000673
so part of: YOR095C
location: complement(<503552..>504328)
location: region:503552-504328:-1
so has part: feature:503552-504328:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:503552-504328:-1:exon

YOR095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RKI1
locus tag: YOR095C
EC number: 5.3.1.6
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004751 ribose-5-phosphate isomerase activity [PMID:8929392]
experiment: EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8929392]
experiment: EXISTENCE:mutant phenotype:GO:0008615 pyridoxine biosynthetic process [PMID:14690456]
note: Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
codon start: 1
product: ribose-5-phosphate isomerase RKI1
translation: MAAGVPKIDALESLGNPLEDAKRAAAYRAVDENLKFDDHKIIGIGSGSTVVYVAERIGQYLHDPKFYEVASKFICIPTGFQSRNLILDNKLQLGSIEQYPRIDIAFDGADEVDENLQLIKGGGACLFQEKLVSTSAKTFIVVADSRKKSPKHLGKNWRQGVPIEIVPSSYVRVKNDLLEQLHAEKVDIRQGGSAKAGPVVTDNNNFIIDADFGEISDPRKLHREIKLLVGVVETGLFIDNASKAYFGNSDGSVEVTEK
SIO_010081: YOR095C
subclass of: SO_0000673
so part of: YOR095C
location: complement(503552..504328)
location: region:503552-504328:-1
so has part: feature:503552-504328:-1:exon

NP_014738.1
type: Protein
SIO_000068: ncbiprotein

S000005621
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:503552-504328:-1:exon

YOR096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS30
gene: RPS7A
locus tag: YOR096W
gene synonym: RPS30
so part of: sequence
location: <505794..>506767
location: region:505794-506767:1
so has part: feature:505794-506767:1:exon
subclass of: SO_0000010

854263
type: Gene
SIO_000068: ncbigene

position:505794:1
position: 505794
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:506767:1
position: 506767
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:505794-506767:1:exon

YOR096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS30
gene: RPS7A
locus tag: YOR096W
gene synonym: RPS30
product: ribosomal 40S subunit protein S7A
transcript id: NM_001183515.1
SIO_010081: YOR096W
subclass of: SO_0000673
so part of: YOR096W
location: join(<505794..505937,506339..>506767)
location: region:505794-506767:1
so has part: feature:505794-505937:1:exon
so has part: feature:506339-506767:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:505794-505937:1:exon

position:505937:1
position: 505937
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:506339-506767:1:exon

position:506339:1
position: 506339
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOR096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS30
gene: RPS7A
locus tag: YOR096W
gene synonym: RPS30
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]
experiment: EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S7A
translation: MSAPQAKILSQAPTELELQVAQAFVELENSSPELKAELRPLQFKSIREIDVAGGKKALAIFVPVPSLAGFHKVQTKLTRELEKKFQDRHVIFLAERRILPKPSRTSRQVQKRPRSRTLTAVHDKILEDLVFPTEIVGKRVRYLVGGNKIQKVLLDSKDVQQIDYKLESFQAVYNKLTGKQIVFEIPSETH
SIO_010081: YOR096W
subclass of: SO_0000673
so part of: YOR096W
location: join(505794..505937,506339..506767)
location: region:505794-506767:1
so has part: feature:505794-505937:1:exon
so has part: feature:506339-506767:1:exon

NP_014739.1
type: Protein
SIO_000068: ncbiprotein

S000005622
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:505794-505937:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:506339-506767:1:exon

YOR097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR097C
so part of: sequence
location: complement(<506978..>507505)
location: region:506978-507505:-1
so has part: feature:506978-507505:-1:exon
subclass of: SO_0000010

854264
type: Gene
SIO_000068: ncbigene

position:506978:-1
position: 506978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507505:-1
position: 507505
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506978-507505:-1:exon

YOR097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR097C
product: uncharacterized protein
transcript id: NM_001183516.1
SIO_010081: YOR097C
subclass of: SO_0000673
so part of: YOR097C
location: complement(<506978..>507505)
location: region:506978-507505:-1
so has part: feature:506978-507505:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506978-507505:-1:exon

YOR097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR097C
note: hypothetical protein; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MDLKRDWLRWKITIGSGPGSIVLDFPSFLVGCVFTTMMGPILQKLIGKLLVGLITVCKFLVIIGSIVFVIGVASKKYTYDDFKVSIKRSGEPGESHDMRTEPKRTAKTATVPMEKDEGVGSYNYFEIPITKETSTIPYINCDGTSSLRKPPNGPSSVGLSNSNRYENFINMARHK
SIO_010081: YOR097C
subclass of: SO_0000673
so part of: YOR097C
location: complement(506978..507505)
location: region:506978-507505:-1
so has part: feature:506978-507505:-1:exon

NP_014740.1
type: Protein
SIO_000068: ncbiprotein

S000005623
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506978-507505:-1:exon

YOR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUP1
locus tag: YOR098C
so part of: sequence
location: complement(<507948..>511178)
location: region:507948-511178:-1
so has part: feature:507948-511178:-1:exon
subclass of: SO_0000010

854265
type: Gene
SIO_000068: ncbigene

position:507948:-1
position: 507948
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511178:-1
position: 511178
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:507948-511178:-1:exon

YOR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUP1
locus tag: YOR098C
product: FG-nucleoporin NUP1
transcript id: NM_001183517.1
SIO_010081: YOR098C
subclass of: SO_0000673
so part of: YOR098C
location: complement(<507948..>511178)
location: region:507948-511178:-1
so has part: feature:507948-511178:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:507948-511178:-1:exon

YOR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUP1
locus tag: YOR098C
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:11046143|PMID:2190694]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:10684247]
experiment: EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]
experiment: EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:16760982|PMID:20098417]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7929578]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11046143|PMID:16118201]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:12411502|PMID:16118201|PMID:7929578]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:10525531|PMID:12917401|PMID:17418788]
note: FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
codon start: 1
product: FG-nucleoporin NUP1
translation: MSSNTSSVMSSPRVEKRSFSSTLKSFFTNPNKKRPSSKKVFSSNLSYANHLEESDVEDTLHVNKRKRVSGTSQHSDSLTQNNNNAPIIIYGTENTERPPLLPILPIQRLRLLREKQRVRNMRELGLIQSTEFPSITSSVILGSQSKSDEGGSYLCTSSTPSPIKNGSCTRQLAGKSGEDTNVGLPILKSLKNRSNRKRFHSQSKGTVWSANFEYDLSEYDAIQKKDNKDKEGNAGGDQKTSENRNNIKSSISNGNLATGPNLTSEIEDLRADINSNRLSNPQKNLLLKGPASTVAKTAPIQESFVPNSERSGTPTLKKNIEPKKDKESIVLPTVGFDFIKDNETPSKKTSPKATSSAGAVFKSSVEMGKTDKSTKTAEAPTLSFNFSQKANKTKAVDNTVPSTTLFNFGGKSDTVTSASQPFKFGKTSEKSENHTESDAPPKSTAPIFSFGKQEENGDEGDDENEPKRKRRLPVSEDTNTKPLFDFGKTGDQKETKKGESEKDASGKPSFVFGASDKQAEGTPLFTFGKKADVTSNIDSSAQFTFGKAATAKETHTKPSETPATIVKKPTFTFGQSTSENKISEGSAKPTFSFSKSEEERKSSPISNEAAKPSFSFPGKPVDVQAPTDDKTLKPTFSFTEPAQKDSSVVSEPKKPSFTFASSKTSQPKPLFSFGKSDAAKEPPGSNTSFSFTKPPANETDKRPTPPSFTFGGSTTNNTTTTSTKPSFSFGAPESMKSTASTAAANTEKLSNGFSFTKFNHNKEKSNSPTSFFDGSASSTPIPVLGKPTDATGNTTSKSAFSFGTANTNGTNASANSTSFSFNAPATGNGTTTTSNTSGTNIAGTFNVGKPDQSIASGNTNGAGSAFGFSSSGTAATGAASNQSSFNFGNNGAGGLNPFTSATSSTNANAGLFNKPPSTNAQNVNVPSAFNFTGNNSTPGGGSVFNMNGNTNANTVFAGSNNQPHQSQTPSFNTNSSFTPSTVPNINFSGLNGGITNTATNALRPSDIFGANAASGSNSNVTNPSSIFGGAGGVPTTSFGQPQSAPNQMGMGTNNGMSMGGGVMANRKIARMRHSKR
SIO_010081: YOR098C
subclass of: SO_0000673
so part of: YOR098C
location: complement(507948..511178)
location: region:507948-511178:-1
so has part: feature:507948-511178:-1:exon

NP_014741.1
type: Protein
SIO_000068: ncbiprotein

S000005624
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:507948-511178:-1:exon

YOR099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KTR1
locus tag: YOR099W
so part of: sequence
location: <511825..>513006
location: region:511825-513006:1
so has part: feature:511825-513006:1:exon
subclass of: SO_0000010

854266
type: Gene
SIO_000068: ncbigene

position:511825:1
position: 511825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:513006:1
position: 513006
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:511825-513006:1:exon

YOR099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KTR1
locus tag: YOR099W
product: alpha-1,2-mannosyltransferase KTR1
transcript id: NM_001183518.1
SIO_010081: YOR099W
subclass of: SO_0000673
so part of: YOR099W
location: <511825..>513006
location: region:511825-513006:1
so has part: feature:511825-513006:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:511825-513006:1:exon

YOR099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KTR1
locus tag: YOR099W
experiment: EXISTENCE:direct assay:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9020857]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]
experiment: EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:9182588]
experiment: EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:9182588]
experiment: EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9182588]
note: Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
codon start: 1
product: alpha-1,2-mannosyltransferase KTR1
translation: MAKIMIPASKQPVYKKLGLLLVAVFTVYVFFHGAQYARGSAPSPKYSTVLSSGSGYKYSKVELPKYTGPREKATFVTLVRNRDLYSLAESIKSVEDRFNSKFNYDWVFLNDEEFTDEFKNVTSALVSGTTKYGVIPKEHWSFPEWIDEEKAAQVRKEMGEKRIIYGDSISYRHMCRFESGFFYRHPLMDDYDWYWRVEPDIKLHCDIDYDVFKFMKDNKKKYAFAISIKEYEATIPTLWETTRKFMEAHPELIHENNMLDFVSDDQGLSYNLCHFWSNFEIAALDLWRSPAYSAYFDYLDREGGFFYERWGDAPVHSIGAALFLDRSEIHHFGDIGYYHVPFHSCPIDTSIRLANKCDCDPSKDFTWHSYSCTTKFYNINKLPKPAGWQNHIG
SIO_010081: YOR099W
subclass of: SO_0000673
so part of: YOR099W
location: 511825..513006
location: region:511825-513006:1
so has part: feature:511825-513006:1:exon

NP_014742.1
type: Protein
SIO_000068: ncbiprotein

S000005625
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:511825-513006:1:exon

YOR100C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRC1
locus tag: YOR100C
so part of: sequence
location: complement(<513295..>514278)
location: region:513295-514278:-1
so has part: feature:513295-514278:-1:exon
subclass of: SO_0000010

854267
type: Gene
SIO_000068: ncbigene

position:513295:-1
position: 513295
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:514278:-1
position: 514278
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513295-514278:-1:exon

YOR100C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRC1
locus tag: YOR100C
product: carnitine:acyl carnitine antiporter
transcript id: NM_001183519.1
SIO_010081: YOR100C
subclass of: SO_0000673
so part of: YOR100C
location: complement(<513295..>514278)
location: region:513295-514278:-1
so has part: feature:513295-514278:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:513295-514278:-1:exon

YOR100C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRC1
locus tag: YOR100C
experiment: EXISTENCE:direct assay:GO:0005476 carnitine:acyl carnitine antiporter activity [PMID:10545096]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10545096]
experiment: EXISTENCE:direct assay:GO:0006631 fatty acid metabolic process [PMID:10545096]
note: Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant
codon start: 1
product: carnitine:acyl carnitine antiporter
translation: MSSDTSLSESSLLKEESGSLTKSRPPIKSNPVRENIKSFVAGGVGGVCAVFTGHPFDLIKVRCQNGQANSTVHAITNIIKEAKTQVKGTLFTNSVKGFYKGVIPPLLGVTPIFAVSFWGYDVGKKLVTFNNKQGGSNELTMGQMAAAGFISAIPTTLVTAPTERVKVVLQTSSKGSFIQAAKTIVKEGGIASLFKGSLATLARDGPGSALYFASYEISKNYLNSRQPRQDAGKDEPVNILNVCLAGGIAGMSMWLAVFPIDTIKTKLQASSTRQNMLSATKEIYLQRGGIKGFFPGLGPALLRSFPANAATFLGVEMTHSLFKKYGI
SIO_010081: YOR100C
subclass of: SO_0000673
so part of: YOR100C
location: complement(513295..514278)
location: region:513295-514278:-1
so has part: feature:513295-514278:-1:exon

NP_014743.1
type: Protein
SIO_000068: ncbiprotein

S000005626
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:513295-514278:-1:exon

YOR101W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAS1
locus tag: YOR101W
so part of: sequence
location: <515244..>516173
location: region:515244-516173:1
so has part: feature:515244-516173:1:exon
subclass of: SO_0000010

854268
type: Gene
SIO_000068: ncbigene

position:515244:1
position: 515244
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516173:1
position: 516173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:515244-516173:1:exon

YOR101W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAS1
locus tag: YOR101W
product: Ras family GTPase RAS1
transcript id: NM_001183520.1
SIO_010081: YOR101W
subclass of: SO_0000673
so part of: YOR101W
location: <515244..>516173
location: region:515244-516173:1
so has part: feature:515244-516173:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:515244-516173:1:exon

YOR101W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAS1
locus tag: YOR101W
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:14674766]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20162532|PMID:3513173]
experiment: EXISTENCE:direct assay:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:3891097]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0045762 positive regulation of adenylate cyclase activity [PMID:2981630|PMID:3891097]
experiment: EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:6327067]
note: GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication
codon start: 1
product: Ras family GTPase RAS1
translation: MQGNKSTIREYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEIRDSELTSSATADREKKNNGSYVLDNSLTNAGTGSSSKSAVNHNGETTKRTDEKNYVNQNNNNEGNTKYSSNGNGNRSDISRGNQNNALNSRSKQSAEPQKNSSANARKESSGGCCIIC
SIO_010081: YOR101W
subclass of: SO_0000673
so part of: YOR101W
location: 515244..516173
location: region:515244-516173:1
so has part: feature:515244-516173:1:exon

NP_014744.1
type: Protein
SIO_000068: ncbiprotein

S000005627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:515244-516173:1:exon

YOR103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OST2
locus tag: YOR103C
so part of: sequence
location: complement(<516449..>516841)
location: region:516449-516841:-1
so has part: feature:516449-516841:-1:exon
subclass of: SO_0000010

854270
type: Gene
SIO_000068: ncbigene

position:516449:-1
position: 516449
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516841:-1
position: 516841
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:516449-516841:-1:exon

YOR103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OST2
locus tag: YOR103C
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
transcript id: NM_001183522.1
SIO_010081: YOR103C
subclass of: SO_0000673
so part of: YOR103C
location: complement(<516449..>516841)
location: region:516449-516841:-1
so has part: feature:516449-516841:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:516449-516841:-1:exon

YOR103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OST2
locus tag: YOR103C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:7593165]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Non-catalytic epsilon subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Wbp1p involved in binding terminal glucose units of the donor glycan; located in the ER lumen
codon start: 1
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
translation: MAKAPKANTPKVTSTSSAVLTDFQETFKTSKRAYFAQIEKYPKLKLIDTFCFFLVLLGVIQCTFIILIRDNFPFNAFLAGFIICVGQFVLLMSLRLQLCNSFPGISKNRAFAEFIVASLILHFVCLHFIN
SIO_010081: YOR103C
subclass of: SO_0000673
so part of: YOR103C
location: complement(516449..516841)
location: region:516449-516841:-1
so has part: feature:516449-516841:-1:exon

NP_014746.2
type: Protein
SIO_000068: ncbiprotein

S000005629
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:516449-516841:-1:exon

YOR104W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PIN2
locus tag: YOR104W
so part of: sequence
location: <517642..>518490
location: region:517642-518490:1
so has part: feature:517642-518490:1:exon
subclass of: SO_0000010

854271
type: Gene
SIO_000068: ncbigene

position:517642:1
position: 517642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:518490:1
position: 518490
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517642-518490:1:exon

YOR104W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PIN2
locus tag: YOR104W
product: Pin2p
transcript id: NM_001183523.1
SIO_010081: YOR104W
subclass of: SO_0000673
so part of: YOR104W
location: <517642..>518490
location: region:517642-518490:1
so has part: feature:517642-518490:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517642-518490:1:exon

YOR104W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PIN2
locus tag: YOR104W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24656818]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:24656818]
note: Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated
codon start: 1
product: Pin2p
translation: MNVCKLKEIVPLFPRSSFTDGVVSTGKSFRSWDTCMDNKACKIIAIVGIVLACILVIWLIGGLLTCFRQGVTGIGQFICWCCRCSNDRNGNNTMPVNEGFSRVNMGVAPPSTVIYQPIQQPESAYYRNDAKNDTFYDEVKTPSNEVYELEEDFDLEKQKEKTRKKQQKERNKEGRSPSRVAPLVYEEENFEGSSPQPQYDARNSFIQNAANTGSNNAHVASQSPIFDISDYGENYYYDNNNINNNLQGNSYNTPSSNHRSPYPTENYQSYQGYKPNQSDRYY
SIO_010081: YOR104W
subclass of: SO_0000673
so part of: YOR104W
location: 517642..518490
location: region:517642-518490:1
so has part: feature:517642-518490:1:exon

NP_014747.1
type: Protein
SIO_000068: ncbiprotein

S000005630
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517642-518490:1:exon

YOR105W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR105W
so part of: sequence
location: <518195..>518521
location: region:518195-518521:1
so has part: feature:518195-518521:1:exon
subclass of: SO_0000010

854272
type: Gene
SIO_000068: ncbigene

position:518195:1
position: 518195
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:518521:1
position: 518521
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:518195-518521:1:exon

YOR105W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR105W
product: uncharacterized protein
transcript id: NM_001270761.1
SIO_010081: YOR105W
subclass of: SO_0000673
so part of: YOR105W
location: <518195..>518521
location: region:518195-518521:1
so has part: feature:518195-518521:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:518195-518521:1:exon

YOR105W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR105W
note: hypothetical protein; expressed at both mRNA and protein levels
codon start: 1
product: uncharacterized protein
translation: MKKKISKVAALSRNMMLEIRLSKMRPILVATTLMLLHNLQFLTSAIMARTIITIIITSIITSRETVTILPPLIIEVHIQPKIINHIRDINQTKAIDITNEVNIYSPFF
SIO_010081: YOR105W
subclass of: SO_0000673
so part of: YOR105W
location: 518195..518521
location: region:518195-518521:1
so has part: feature:518195-518521:1:exon

NP_001257690.1
type: Protein
SIO_000068: ncbiprotein

S000005631
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:518195-518521:1:exon

YOR106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PTH1
gene: VAM3
locus tag: YOR106W
gene synonym: PTH1
so part of: sequence
location: <519121..>519972
location: region:519121-519972:1
so has part: feature:519121-519972:1:exon
subclass of: SO_0000010

854273
type: Gene
SIO_000068: ncbigene

position:519121:1
position: 519121
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:519972:1
position: 519972
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519121-519972:1:exon

YOR106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PTH1
gene: VAM3
locus tag: YOR106W
gene synonym: PTH1
product: SNAP receptor VAM3
transcript id: NM_001183525.1
SIO_010081: YOR106W
subclass of: SO_0000673
so part of: YOR106W
location: <519121..>519972
location: region:519121-519972:1
so has part: feature:519121-519972:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:519121-519972:1:exon

YOR106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PTH1
gene: VAM3
locus tag: YOR106W
gene synonym: PTH1
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9202390|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:17054985]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9425154]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9685264]
experiment: EXISTENCE:genetic interaction:GO:0048278 vesicle docking [PMID:9245783]
experiment: EXISTENCE:genetic interaction:GO:0051469 vesicle fusion with vacuole [PMID:9245783]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0097352 autophagosome maturation [PMID:9202390]
note: Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
codon start: 1
product: SNAP receptor VAM3
translation: MSFFDIEAQSSKGNSQQEPQFSTNQKTKELSNLIETFAEQSRVLEKECTKIGSKRDSKELRYKIETELIPNCTSVRDKIESNILIHQNGKLSADFKNLKTKYQSLQQSYNQRKSLFPLKTPISPGTSKERKDIHPRTEAVRQDPESSYISIKVNEQSPLLHNEGQHQLQLQEEQEQQQQGLSQEELDFQTIIHQERSQQIGRIHTAVQEVNAIFHQLGSLVKEQGEQVTTIDENISHLHDNMQNANKQLTRADQHQRDRNKCGKVTLIIIIVVCMVVLLAVLS
SIO_010081: YOR106W
subclass of: SO_0000673
so part of: YOR106W
location: 519121..519972
location: region:519121-519972:1
so has part: feature:519121-519972:1:exon

NP_014749.1
type: Protein
SIO_000068: ncbiprotein

S000005632
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519121-519972:1:exon

YOR107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RGS2
locus tag: YOR107W
so part of: sequence
location: <521353..>522282
location: region:521353-522282:1
so has part: feature:521353-522282:1:exon
subclass of: SO_0000010

854274
type: Gene
SIO_000068: ncbigene

position:521353:1
position: 521353
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522282:1
position: 522282
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:521353-522282:1:exon

YOR107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RGS2
locus tag: YOR107W
product: GTPase-activating protein RGS2
transcript id: NM_001183526.3
SIO_010081: YOR107W
subclass of: SO_0000673
so part of: YOR107W
location: <521353..>522282
location: region:521353-522282:1
so has part: feature:521353-522282:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:521353-522282:1:exon

YOR107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RGS2
locus tag: YOR107W
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10523302]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [PMID:10523302]
note: Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
codon start: 1
product: GTPase-activating protein RGS2
translation: MASVPSLCDILIPLEKNSRSDGDAESSNTVLIQLRKGHHERMRSPYTIQKFYKFLKRAHCEENLEFFEKAHQFLQLKQNRSISEEKLLEVWNKSLYIKYIAVDSPKECNFSQDTREIFEKCFANNEVPADVDVLCAISHVMGLLMDGYHRFVSSVNEKKYSATYAHNDSATEQDLKNESTTSFSSLGVEDISEDRNSYLKKPDINGLSTIIQETSANTTNESQCSDRTSRPSESSSSLNTTSSTYKNTSTRNLQKPQNTGILNSGKGLLQKLNFVKKRKSFKQPSGVICSHYNSNVQNRLKGQNSHQQR
SIO_010081: YOR107W
subclass of: SO_0000673
so part of: YOR107W
location: 521353..522282
location: region:521353-522282:1
so has part: feature:521353-522282:1:exon

NP_014750.3
type: Protein
SIO_000068: ncbiprotein

S000005633
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:521353-522282:1:exon

YOR108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LEU9
locus tag: YOR108W
so part of: sequence
location: <523027..>524841
location: region:523027-524841:1
so has part: feature:523027-524841:1:exon
subclass of: SO_0000010

854275
type: Gene
SIO_000068: ncbigene

position:523027:1
position: 523027
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524841:1
position: 524841
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523027-524841:1:exon

YOR108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LEU9
locus tag: YOR108W
product: 2-isopropylmalate synthase LEU9
transcript id: NM_001183527.1
SIO_010081: YOR108W
subclass of: SO_0000673
so part of: YOR108W
location: <523027..>524841
location: region:523027-524841:1
so has part: feature:523027-524841:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523027-524841:1:exon

YOR108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LEU9
locus tag: YOR108W
EC number: 2.3.3.13
experiment: EXISTENCE:direct assay:GO:0003852 2-isopropylmalate synthase activity [PMID:11158296|PMID:25841022]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11158296|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0003852 2-isopropylmalate synthase activity [PMID:10790691]
experiment: EXISTENCE:genetic interaction:GO:0009098 leucine biosynthetic process [PMID:10790691]
experiment: EXISTENCE:mutant phenotype:GO:0009098 leucine biosynthetic process [PMID:25841022]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:25841022]
note: Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication
codon start: 1
product: 2-isopropylmalate synthase LEU9
translation: MVKHSFIALAEHASKLRRSIPPVKLTYKNMLRDPSVKYRAFAPPKMVKRIWPDKTIQKAPRWLSTDLRDGNQSLPDPMSVAQKKEYFHKLINIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVGIQCLVQSREHLIKRTVEALTGAKRATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFSTHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSISEIVHRCNKIPIPPRAPYGGELVVSAFSGSHQDAIKKGFAIQNKKQAQGETRWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVIMRSLGLDVPRPMQVDFSNTLQKNADALGRELKSEEITKLFKETYNYNNNEHIYVTLLNYEVKKLNPERRALVGQVEINDKVVNIEGYGNGPISSLVDALSNLLNVKLSVQNYSEHSLGSGSATQAASFINLSYIKDINNHATSNMWGVGVSEDTGDASIKAVFATVNNIIHSGDVLLAE
SIO_010081: YOR108W
subclass of: SO_0000673
so part of: YOR108W
location: 523027..524841
location: region:523027-524841:1
so has part: feature:523027-524841:1:exon

NP_014751.1
type: Protein
SIO_000068: ncbiprotein

S000005634
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523027-524841:1:exon

YOR109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SJL3
alternative label: SOP2
gene: INP53
locus tag: YOR109W
gene synonym: SJL3; SOP2
so part of: sequence
location: <525278..>528601
location: region:525278-528601:1
so has part: feature:525278-528601:1:exon
subclass of: SO_0000010

854276
type: Gene
SIO_000068: ncbigene

position:525278:1
position: 525278
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:528601:1
position: 528601
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525278-528601:1:exon

YOR109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SJL3
alternative label: SOP2
gene: INP53
locus tag: YOR109W
gene synonym: SJL3; SOP2
product: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
transcript id: NM_001183528.3
SIO_010081: YOR109W
subclass of: SO_0000673
so part of: YOR109W
location: <525278..>528601
location: region:525278-528601:1
so has part: feature:525278-528601:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525278-528601:1:exon

YOR109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SJL3
alternative label: SOP2
gene: INP53
locus tag: YOR109W
gene synonym: SJL3; SOP2
EC number: 3.1.3.36
experiment: EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11094088]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:9560389]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11094088]
experiment: EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]
experiment: EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131]
experiment: EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9438131]
note: Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53
translation: MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYPVLPETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDVNGQPEALLGDENPIEPEEKAKLNHMTLDSWQPLTPK
SIO_010081: YOR109W
subclass of: SO_0000673
so part of: YOR109W
location: 525278..528601
location: region:525278-528601:1
so has part: feature:525278-528601:1:exon

NP_014752.3
type: Protein
SIO_000068: ncbiprotein

S000005635
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525278-528601:1:exon

YOR110W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TFC7
locus tag: YOR110W
so part of: sequence
location: <528941..>530248
location: region:528941-530248:1
so has part: feature:528941-530248:1:exon
subclass of: SO_0000010

854277
type: Gene
SIO_000068: ncbigene

position:528941:1
position: 528941
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:530248:1
position: 530248
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:528941-530248:1:exon

YOR110W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TFC7
locus tag: YOR110W
product: transcription factor TFIIIC subunit TFC7
transcript id: NM_001183529.1
SIO_010081: YOR110W
subclass of: SO_0000673
so part of: YOR110W
location: <528941..>530248
location: region:528941-530248:1
so has part: feature:528941-530248:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:528941-530248:1:exon

YOR110W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TFC7
locus tag: YOR110W
experiment: EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:1474578|PMID:2002052|PMID:9584160]
experiment: EXISTENCE:direct assay:GO:0000995 RNA polymerase III general transcription initiation factor activity [PMID:9584160]
experiment: EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]
experiment: EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]
experiment: EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:8464480|PMID:2183033|PMID:9584160]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]
experiment: EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:23569204]
experiment: EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]
experiment: EXISTENCE:mutant phenotype:GO:0000995 RNA polymerase III general transcription initiation factor activity [PMID:9584160]
experiment: EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:9584160]
note: RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication
codon start: 1
product: transcription factor TFIIIC subunit TFC7
translation: MVVNTIYIARHGYRSNWLPEGPYPDPLTGIDSDVPLAEHGVQQAKELAHYLLSLDNQPEAAFASPFYRCLETVQPIAKLLEIPVYLERGIGEWYRPDRKPVIPVPAGYEILSKFFPGVISQEWDSTLTPNEKGETEQEMYMRFKKFWPLFIERVEKEYPNVECILLVTHAASKIALGMSLLGYDNPRMSLNENGDKIRSGSCSLDKYEILKKSYDTIDETDDQTSFTYIPFSDRKWVLTMNGNTEFLSSGEEMNWNFDCVAEAGSDADIKKRQMTKKTSSPIPEADDQTEVETVYISVDIPSGNYKERTEIAKSAILQYSGLETDAPLFRIGNRLYEGSWERLVGTELAFPNAAHVHKKTAGLLSPTEENETTNAGQSKGSSTANDPNIQIQEEDVGLPDSTNTSRDHTGDKEEVQSEKIYRIKERIVLSNVRPM
SIO_010081: YOR110W
subclass of: SO_0000673
so part of: YOR110W
location: 528941..530248
location: region:528941-530248:1
so has part: feature:528941-530248:1:exon

NP_014753.1
type: Protein
SIO_000068: ncbiprotein

S000005636
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:528941-530248:1:exon

YOR111W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR111W
so part of: sequence
location: <530429..>531127
location: region:530429-531127:1
so has part: feature:530429-531127:1:exon
subclass of: SO_0000010

854278
type: Gene
SIO_000068: ncbigene

position:530429:1
position: 530429
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:531127:1
position: 531127
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:530429-531127:1:exon

YOR111W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR111W
product: nucleotide diphosphatase
transcript id: NM_001183530.3
SIO_010081: YOR111W
subclass of: SO_0000673
so part of: YOR111W
location: <530429..>531127
location: region:530429-531127:1
so has part: feature:530429-531127:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:530429-531127:1:exon

YOR111W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR111W
EC number: 3.6.1.9
codon start: 1
product: nucleotide diphosphatase
translation: MSGNSQLPPDVIGFICSKYDIILASTSPRRYEILHDIMGITDLKTMVSTFEENLDKMNYSTDPIGYVCDTSWHKAQNIIEILTDYEDENPNEIDKPKLIICADTIIIDKSGRIYEKPKTKEVQKKFLMKFCYEDDEPVNVVTAVTLIKWYGRENFELVPFRDETKVYFDNKIPLRILEEYVESGDGLEVGGGFKIQGQGAILIEKIEGDYYNVVGLPLNKTFKGLYAEANSI
SIO_010081: YOR111W
subclass of: SO_0000673
so part of: YOR111W
location: 530429..531127
location: region:530429-531127:1
so has part: feature:530429-531127:1:exon

NP_014754.3
type: Protein
SIO_000068: ncbiprotein

S000005637
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:530429-531127:1:exon

YOR112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CEX1
locus tag: YOR112W
so part of: sequence
location: <531508..>533793
location: region:531508-533793:1
so has part: feature:531508-533793:1:exon
subclass of: SO_0000010

854279
type: Gene
SIO_000068: ncbigene

position:531508:1
position: 531508
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:533793:1
position: 533793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:531508-533793:1:exon

YOR112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CEX1
locus tag: YOR112W
product: Cex1p
transcript id: NM_001183531.1
SIO_010081: YOR112W
subclass of: SO_0000673
so part of: YOR112W
location: <531508..>533793
location: region:531508-533793:1
so has part: feature:531508-533793:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:531508-533793:1:exon

YOR112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CEX1
locus tag: YOR112W
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:17203074]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:17203074]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17203074|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:22008473]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:17203074]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:33753324]
experiment: EXISTENCE:physical interaction:GO:0005643 nuclear pore [PMID:17203074]
experiment: EXISTENCE:physical interaction:GO:0006409 tRNA export from nucleus [PMID:17203074]
note: Component of COPI-mediated trafficking and tRNA nuclear export; enables Rna1p to access and activate Gsp1p-GTP bound to the export receptor tRNA complex during aminoacylation-dependent tRNA export; copurifies with tRNA export receptors; interacts with COPI coat proteins and regulates Golgi-to-ER trafficking; membrane fraction associated; mutations in members of the homologous human SCY1-like (SCYL) family of pseudokinases are linked to peripheral neuropathy, cerebellar atrophy, ataxia and ALS
codon start: 1
product: Cex1p
translation: MNFSSIFKSISNFQFPYTIEETAITETALWQCFDGTRKADSLPVTVFKAKRSPENESLILNAVHKSKILKIPGLCTVLETFDSDPQSTFIVTERVVPFPWDNLGSLSQNKFGVELGISQLLATLGFLKNFVLGTLSKDSVFINIKGEWVLFGLELCSSKEGLSAFEFASRARSYYNIIGSQLPCEDPNTIDSMGLGLLIKSLMAPSCLPKDWIVNVNMISDGKITIENFRKRLENTETWRSNPLINFYQELRELHIKDPQGKLVVMSNLENLYLESREIFRNLTPGMIENFIIPELCEIIKLLMTQSISSAASPIGMNFNASHKLVPFLAIVLDLTSETNTFPVGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLSKSEISSRIYPHFIQGLTDSDATLRLQTLKTIPCIVSCLTERQLNNELLRFLAKTQVDSDVEIRTWTVIIISKISTILSTSVGNRSNILATAFTKSLKDPQVKPRLAALYGLEKSIELFDVNTIANKILTVIAPGLLDKSPIVRGRAKILFEEYLEKLEKEAQLIQTNDSTADSEDVKDIDFENYGCDEEDMNKEDNLLAAQFLNNLRLNSPSATTPSNITESEIDSAQDGSGWDDLSDTDGFITNGTTESFDETTNPVTTASTPKLFGKPIKINKSWNDELNDDGWIQDESGPSKVPQKHTRPQNSTLAKSIAPSSRLSIKKKKTTILAPRNIASNSTVTTKSSLSNKTARSKPISSIRGSVTKKGNVDGWDDDGDSDSWDTNW
SIO_010081: YOR112W
subclass of: SO_0000673
so part of: YOR112W
location: 531508..533793
location: region:531508-533793:1
so has part: feature:531508-533793:1:exon

NP_014755.1
type: Protein
SIO_000068: ncbiprotein

S000005638
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:531508-533793:1:exon

YOR113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AZF1
locus tag: YOR113W
so part of: sequence
location: <534075..>536819
location: region:534075-536819:1
so has part: feature:534075-536819:1:exon
subclass of: SO_0000010

854280
type: Gene
SIO_000068: ncbigene

position:534075:1
position: 534075
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:536819:1
position: 536819
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:534075-536819:1:exon

YOR113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AZF1
locus tag: YOR113W
product: Azf1p
transcript id: NM_001183532.3
SIO_010081: YOR113W
subclass of: SO_0000673
so part of: YOR113W
location: <534075..>536819
location: region:534075-536819:1
so has part: feature:534075-536819:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:534075-536819:1:exon

YOR113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AZF1
locus tag: YOR113W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11839825|PMID:16467472]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11839825]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:9799362|PMID:16467472]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11839825]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:16467472]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11839825]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11839825]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:16467472]
experiment: EXISTENCE:mutant phenotype:GO:0071322 cellular response to carbohydrate stimulus [PMID:11839825|PMID:16467472]
note: Zinc-finger transcription factor; involved in the diauxic shift; activates transcription of genes involved in carbon metabolism and energy production on glucose, while it activates transcription of genes involved in cell wall organization and biogenesis on glycerol-lactate; may also function as a co-repressor; capable of forming the prion [AZF1+]; relocalizes to the cytosol in response to hypoxia; contains polyglutamine and polyasparagine domains
codon start: 1
product: Azf1p
translation: MPPPTAQFMGPTQAGQNESQNQSSGEAGEQNQEHGQGPTPILNQSQPASSQPQHQQQRNESISYYTNFNQPRYSTDASINSFLNISDNVPVTSTGGPSSGGAYSNLPRLSTSSTHQPPDLSQIGRGFSIVNNLFPQQQQLQNQHRQQQQQQQQQSHQQPPFKTPSFSTGLTGSSSQYQFLPRNDNTSQPPSKRNSVYLGPNDGPDFEFFSMQQSQQPQFQPSSRRESNSMRPPLLIPAATTKSQSNGTNNSGNMNTNADYESFFNTGTNNSNSNQNPYFLSSRNNSLKFNPEDFDFQFKRRNSFVRGTLDHSSQNAFIPESRLNSLSVNNKANGDPVADNVTNNMKGKSNEVDNDDGNDSSNNNNNNNNNNNNENNNDNNNDNNDNSINSATSTNIPNQEDHSLASTDTTSNSRKDLKEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEGLNKHIDESGMQPNIIKKRKKDDSTVYVKNEMPRTDPPMSKDNSTSAEGAAMANFSGKEPPIPDISSVSDDATNLIGATKVDQLMLIIQARKKGFTEKVNTTQDGDLLFNQTMDILPPKSELVGGVEKPKGTQNTRAVKKHECPYCHRLFSQATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLVTHQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFASIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSENNGNPEGNIDSSSNSNPGSHSMISPTQKDMGTLQSQFIQNNFNNSVNSSNPSNQPIINYNYTTLPHSRLGSSSSSNTNNNNSNFSVGAAPGVLMAPTTNNDFSFNLDQSNDNERSQQEQVRFKNINYKS
SIO_010081: YOR113W
subclass of: SO_0000673
so part of: YOR113W
location: 534075..536819
location: region:534075-536819:1
so has part: feature:534075-536819:1:exon

NP_014756.3
type: Protein
SIO_000068: ncbiprotein

S000005639
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:534075-536819:1:exon

YOR114W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPI34
locus tag: YOR114W
so part of: sequence
location: <537570..>538454
location: region:537570-538454:1
so has part: feature:537570-538454:1:exon
subclass of: SO_0000010

854281
type: Gene
SIO_000068: ncbigene

position:537570:1
position: 537570
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538454:1
position: 538454
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:537570-538454:1:exon

YOR114W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPI34
locus tag: YOR114W
product: Dpi34p
transcript id: NM_001183533.1
SIO_010081: YOR114W
subclass of: SO_0000673
so part of: YOR114W
location: <537570..>538454
location: region:537570-538454:1
so has part: feature:537570-538454:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:537570-538454:1:exon

YOR114W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPI34
locus tag: YOR114W
note: Putative mitochondrial hypothetical protein; null mutant is viable
codon start: 1
product: Dpi34p
translation: MKATLLLKAQLSPVSYTTKKSFQRQLNRTPYTAFQYFFQLEVQKLHNVSKYEDIINHVRGNSNFKRFARNEWDSMSLTKKRLYYASFCQSMDIDILNVSKIELAKRLEIPIPAMSEYLLFRNKFKVKFDSHCSSLERKDRKSVPRPSITRKVATTEICSKSRSNTPVGKINPRKRLVALKRISRSENTAKNHSHEAQNYLYDYMKRFQQMCKECRYAWNEEVDYDQKLEIRKKLQVWRAKFEEMMDNEIQILQKNMDIMSKFGLRSESYLTAANHDTNTQPNNILPMTYLLKKK
SIO_010081: YOR114W
subclass of: SO_0000673
so part of: YOR114W
location: 537570..538454
location: region:537570-538454:1
so has part: feature:537570-538454:1:exon

NP_014757.1
type: Protein
SIO_000068: ncbiprotein

S000005640
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:537570-538454:1:exon

YOR115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRS33
locus tag: YOR115C
so part of: sequence
location: complement(<538659..>539465)
location: region:538659-539465:-1
so has part: feature:538659-539465:-1:exon
subclass of: SO_0000010

854282
type: Gene
SIO_000068: ncbigene

position:538659:-1
position: 538659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:539465:-1
position: 539465
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538659-539465:-1:exon

YOR115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRS33
locus tag: YOR115C
product: Trs33p
transcript id: NM_001183534.3
SIO_010081: YOR115C
subclass of: SO_0000673
so part of: YOR115C
location: complement(<538659..>539465)
location: region:538659-539465:-1
so has part: feature:538659-539465:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538659-539465:-1:exon

YOR115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRS33
locus tag: YOR115C
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:27672095]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:19843283]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:19843283]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9564032]
experiment: EXISTENCE:genetic interaction:GO:0016239 positive regulation of macroautophagy [PMID:27672095]
experiment: EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:27672095]
experiment: EXISTENCE:genetic interaction:GO:0034497 protein localization to phagophore assembly site [PMID:27672095]
experiment: EXISTENCE:genetic interaction:GO:0065003 protein-containing complex assembly [PMID:19843283]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:27672095]
note: Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy
codon start: 1
product: Trs33p
translation: MSSTHSNNVGHPQSSPQGPLTEQQRAQQQYQIFENSLPKVSQSVYQMLLNEMVPLAMGIERQISGDVISSDSNVTSENGNINNMIKRLKIEEHHTVDIIRSHNLIHELYKADEEEKEKVLARLRNIGFQIGLKLSELLIFSNNPNLKFKEMDLLLIMKFICRDVWKQIFGKQIDNLKTNHRGTFYLLDYDYRPIQSFSLEEDAKNEELKMIEPFLEIPVGIIRGVLSSLGYSSEEVICLASFIDRPTDRPKTAFPKGVSFHVQVTMPQ
SIO_010081: YOR115C
subclass of: SO_0000673
so part of: YOR115C
location: complement(538659..539465)
location: region:538659-539465:-1
so has part: feature:538659-539465:-1:exon

NP_014758.3
type: Protein
SIO_000068: ncbiprotein

S000005641
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538659-539465:-1:exon

YOR116C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPC1
alternative label: RPC160
gene: RPO31
locus tag: YOR116C
gene synonym: RPC1; RPC160
so part of: sequence
location: complement(<539763..>544145)
location: region:539763-544145:-1
so has part: feature:539763-544145:-1:exon
subclass of: SO_0000010

854283
type: Gene
SIO_000068: ncbigene

position:539763:-1
position: 539763
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:544145:-1
position: 544145
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:539763-544145:-1:exon

YOR116C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPC1
alternative label: RPC160
gene: RPO31
locus tag: YOR116C
gene synonym: RPC1; RPC160
product: DNA-directed RNA polymerase III core subunit RPO31
transcript id: NM_001183535.1
SIO_010081: YOR116C
subclass of: SO_0000673
so part of: YOR116C
location: complement(<539763..>544145)
location: region:539763-544145:-1
so has part: feature:539763-544145:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:539763-544145:-1:exon

YOR116C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPC1
alternative label: RPC160
gene: RPO31
locus tag: YOR116C
gene synonym: RPC1; RPC160
EC number: 2.7.7.6
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
note: RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
codon start: 1
product: DNA-directed RNA polymerase III core subunit RPO31
translation: MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALKAN
SIO_010081: YOR116C
subclass of: SO_0000673
so part of: YOR116C
location: complement(539763..544145)
location: region:539763-544145:-1
so has part: feature:539763-544145:-1:exon

NP_014759.1
type: Protein
SIO_000068: ncbiprotein

S000005642
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:539763-544145:-1:exon

YOR117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YTA1
gene: RPT5
locus tag: YOR117W
gene synonym: YTA1
so part of: sequence
location: <545029..>546333
location: region:545029-546333:1
so has part: feature:545029-546333:1:exon
subclass of: SO_0000010

854284
type: Gene
SIO_000068: ncbigene

position:545029:1
position: 545029
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:546333:1
position: 546333
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545029-546333:1:exon

YOR117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YTA1
gene: RPT5
locus tag: YOR117W
gene synonym: YTA1
product: proteasome regulatory particle base subunit RPT5
transcript id: NM_001183536.3
SIO_010081: YOR117W
subclass of: SO_0000673
so part of: YOR117W
location: <545029..>546333
location: region:545029-546333:1
so has part: feature:545029-546333:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:545029-546333:1:exon

YOR117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YTA1
gene: RPT5
locus tag: YOR117W
gene synonym: YTA1
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:11742986|PMID:9741626]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9724628]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]
experiment: EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]
note: ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
codon start: 1
product: proteasome regulatory particle base subunit RPT5
translation: MATLEELDAQTLPGDDELDQEILNLSTQELQTRAKLLDNEIRIFRSELQRLSHENNVMLEKIKDNKEKIKNNRQLPYLVANVVEVMDMNEIEDKENSESTTQGGNVNLDNTAVGKAAVVKTSSRQTVFLPMVGLVDPDKLKPNDLVGVNKDSYLILDTLPSEFDSRVKAMEVDEKPTETYSDVGGLDKQIEELVEAIVLPMKRADKFKDMGIRAPKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLVQMYIGEGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPSEDSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGISEVQARKSKSVSFYA
SIO_010081: YOR117W
subclass of: SO_0000673
so part of: YOR117W
location: 545029..546333
location: region:545029-546333:1
so has part: feature:545029-546333:1:exon

NP_014760.3
type: Protein
SIO_000068: ncbiprotein

S000005643
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545029-546333:1:exon

YOR118W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTC5
locus tag: YOR118W
so part of: sequence
location: <546857..>548560
location: region:546857-548560:1
so has part: feature:546857-548560:1:exon
subclass of: SO_0000010

854285
type: Gene
SIO_000068: ncbigene

position:546857:1
position: 546857
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:548560:1
position: 548560
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546857-548560:1:exon

YOR118W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTC5
locus tag: YOR118W
product: Rtc5p
transcript id: NM_001183537.1
SIO_010081: YOR118W
subclass of: SO_0000673
so part of: YOR118W
location: <546857..>548560
location: region:546857-548560:1
so has part: feature:546857-548560:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546857-548560:1:exon

YOR118W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTC5
locus tag: YOR118W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
codon start: 1
product: Rtc5p
translation: MGQSSSISSSNEEGSSHSKKFTNSKDILAYFNNKAQQQVTIPELVSFKGNLQIEDLNTPISHKALCNSLYFPQNHAMIVGIVTNMLRVLSNFPLMKSSYEPITGYGLLKCILLLNRARCAKFLKTKSYDQLKLLFISLSLQKTDKEELSEESENDGNKELTIKQIITGFDDVDTEMLCIPADFMLQFLTWLLILTVDCPTTNSKLDNTETHDQWGNFKVSALNLLRTMNPDVVGDIESHSITFQQFSTAIRTVMPNLLKPLENLMEHFFYLQHDLVDHDTNLSSIQDSKVMTPALLAQLSTGLPKELFIHKLQSLYIGRKSGFSMRSLQAKVFKWMAPSILVVSGMRITNSEEYAAEKNPRYRHFLEEFPKLKESDQMMDASHLNKRKTTFAVYIDDPWKVTNKDYFGDLNTRIIEISPRQDIYKVNQKGTIYFNTIGGGIGIGDKQPLIKPASKRYIPGNVSLTFDSTLEFAVFRNTGYGGSLDPGLLSMERKEENSPYELHFLIQDVEVWGCGGEKELEEQIKQLEWEEAESKRRQQINLRSLGEDRALLEMAGLVGQHQGGGSM
SIO_010081: YOR118W
subclass of: SO_0000673
so part of: YOR118W
location: 546857..548560
location: region:546857-548560:1
so has part: feature:546857-548560:1:exon

NP_014761.1
type: Protein
SIO_000068: ncbiprotein

S000005644
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546857-548560:1:exon

YOR119C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRP10
gene: RIO1
locus tag: YOR119C
gene synonym: RRP10
so part of: sequence
location: complement(<548792..>550246)
location: region:548792-550246:-1
so has part: feature:548792-550246:-1:exon
subclass of: SO_0000010

854286
type: Gene
SIO_000068: ncbigene

position:548792:-1
position: 548792
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550246:-1
position: 550246
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548792-550246:-1:exon

YOR119C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRP10
gene: RIO1
locus tag: YOR119C
gene synonym: RRP10
product: protein kinase RIO1
transcript id: NM_001183538.3
SIO_010081: YOR119C
subclass of: SO_0000673
so part of: YOR119C
location: complement(<548792..>550246)
location: region:548792-550246:-1
so has part: feature:548792-550246:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548792-550246:-1:exon

YOR119C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRP10
gene: RIO1
locus tag: YOR119C
gene synonym: RRP10
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12612080|PMID:11483523]
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11972772|PMID:25851096]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12612080|PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11483523]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:30011030]
experiment: EXISTENCE:direct assay:GO:0007096 regulation of exit from mitosis [PMID:11972772]
experiment: EXISTENCE:direct assay:GO:0030874 nucleolar chromatin [PMID:25851096]
experiment: EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:25851096]
experiment: EXISTENCE:mutant phenotype:GO:2000234 positive regulation of rRNA processing [PMID:25851096]
note: Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain; prevents premature use of pre-40S particles in translation; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; phosphorylates Rpa43p in anaphase to remove Pol I from rDNA
codon start: 1
product: protein kinase RIO1
translation: MSLEDKFDSLSVSQGASDHINNQLLEKYSHKIKTDELSFSRAKTSKDKANRATVENVLDPRTMRFLKSMVTRGVIADLNGCLSTGKEANVYHAFAGTGKAPVIDEETGQYEVLETDGSRAEYAIKIYKTSILVFKDRERYVDGEFRFRNSRSQHNPRKMIKIWAEKEFRNLKRIYQSGVIPAPKPIEVKNNVLVMEFLSRGNGFASPKLKDYPYKNRDEIFHYYHTMVAYMRLLYQVCRLVHADLSEYNTIVHDDKLYMIDVSQSVEPEHPMSLDFLRMDIKNVNLYFEKMGISIFPERVIFQFVISETLEKFKGDYNNISALVAYIASNLPIKSTEQDEAEDEIFRSLHLVRSLGGLEERDFDRYTDGKFDLLKSLIAHDNERNFAASEQFEFDNADHECSSGTEEFSDDEEDGSSGSEEDDEEEGEYYDDDEPKVLKGKKHEDKDLKKLRKQEAKDAKREKRKTKVKKHIKKKLVKKTKSKK
SIO_010081: YOR119C
subclass of: SO_0000673
so part of: YOR119C
location: complement(548792..550246)
location: region:548792-550246:-1
so has part: feature:548792-550246:-1:exon

NP_014762.3
type: Protein
SIO_000068: ncbiprotein

S000005645
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548792-550246:-1:exon

YOR120W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GCY1
locus tag: YOR120W
so part of: sequence
location: <551114..>552052
location: region:551114-552052:1
so has part: feature:551114-552052:1:exon
subclass of: SO_0000010

854287
type: Gene
SIO_000068: ncbigene

position:551114:1
position: 551114
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552052:1
position: 552052
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551114-552052:1:exon

YOR120W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GCY1
locus tag: YOR120W
product: glycerol 2-dehydrogenase (NADP(+)) GCY1
transcript id: NM_001183539.1
SIO_010081: YOR120W
subclass of: SO_0000673
so part of: YOR120W
location: <551114..>552052
location: region:551114-552052:1
so has part: feature:551114-552052:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551114-552052:1:exon

YOR120W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GCY1
locus tag: YOR120W
EC number: 1.1.1.156
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]
experiment: EXISTENCE:direct assay:GO:0004032 alditol:NADP+ 1-oxidoreductase activity [PMID:11306085]
experiment: EXISTENCE:direct assay:GO:0004033 aldo-keto reductase (NADP) activity [PMID:17140678|PMID:10818358]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:17962934]
experiment: EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]
experiment: EXISTENCE:direct assay:GO:0042843 D-xylose catabolic process [PMID:12271459]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]
experiment: EXISTENCE:genetic interaction:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]
experiment: EXISTENCE:mutant phenotype:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]
experiment: EXISTENCE:mutant phenotype:GO:1990042 glycerol dehydrogenase [NAD(P)+] activity [PMID:22979944]
note: Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
codon start: 1
product: glycerol 2-dehydrogenase (NADP(+)) GCY1
translation: MPATLHDSTKILSLNTGAQIPQIGLGTWQSKENDAYKAVLTALKDGYRHIDTAAIYRNEDQVGQAIKDSGVPREEIFVTTKLWCTQHHEPEVALDQSLKRLGLDYVDLYLMHWPARLDPAYIKNEDILSVPTKKDGSRAVDITNWNFIKTWELMQELPKTGKTKAVGVSNFSINNLKDLLASQGNKLTPAANQVEIHPLLPQDELINFCKSKGIVVEAYSPLGSTDAPLLKEPVILEIAKKNNVQPGHVVISWHVQRGYVVLPKSVNPDRIKTNRKIFTLSTEDFEAINNISKEKGEKRVVHPNWSPFEVFK
SIO_010081: YOR120W
subclass of: SO_0000673
so part of: YOR120W
location: 551114..552052
location: region:551114-552052:1
so has part: feature:551114-552052:1:exon

NP_014763.1
type: Protein
SIO_000068: ncbiprotein

S000005646
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551114-552052:1:exon

YOR122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLS5
alternative label: PRF1
gene: PFY1
locus tag: YOR122C
gene synonym: CLS5; PRF1
so part of: sequence
location: complement(<552298..>552887)
location: region:552298-552887:-1
so has part: feature:552298-552887:-1:exon
subclass of: SO_0000010

854289
type: Gene
SIO_000068: ncbigene

position:552298:-1
position: 552298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552887:-1
position: 552887
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552298-552887:-1:exon

YOR122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLS5
alternative label: PRF1
gene: PFY1
locus tag: YOR122C
gene synonym: CLS5; PRF1
product: profilin
transcript id: NM_001183541.3
SIO_010081: YOR122C
subclass of: SO_0000673
so part of: YOR122C
location: complement(join(<552298..552665,552875..>552887))
location: region:552298-552887:-1
so has part: feature:552875-552887:-1:exon
so has part: feature:552298-552665:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552875-552887:-1:exon

position:552875:-1
position: 552875
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:552298-552665:-1:exon

position:552665:-1
position: 552665
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YOR122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLS5
alternative label: PRF1
gene: PFY1
locus tag: YOR122C
gene synonym: CLS5; PRF1
experiment: EXISTENCE:direct assay:GO:0003785 actin monomer binding [PMID:10953013]
experiment: EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:8247001]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:7592954]
experiment: EXISTENCE:direct assay:GO:0042989 sequestering of actin monomers [PMID:10953013]
experiment: EXISTENCE:direct assay:GO:0070064 proline-rich region binding [PMID:8247001|PMID:9698363]
experiment: EXISTENCE:direct assay:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12134165]
experiment: EXISTENCE:genetic interaction:GO:0046907 intracellular transport [PMID:9720869]
experiment: EXISTENCE:mutant phenotype:GO:0003785 actin monomer binding [PMID:10953013]
experiment: EXISTENCE:mutant phenotype:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:8247001]
experiment: EXISTENCE:mutant phenotype:GO:0042989 sequestering of actin monomers [PMID:10953013]
experiment: EXISTENCE:mutant phenotype:GO:0070064 proline-rich region binding [PMID:8247001]
experiment: EXISTENCE:mutant phenotype:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12134165]
experiment: EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]
note: Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS
codon start: 1
product: profilin
translation: MSWQAYTDNLIGTGKVDKAVIYSRAGDAVWATSGGLSLQPNEIGEIVQGFDNPAGLQSNGLHIQGQKFMLLRADDRSIYGRHDAEGVVCVRTKQTVIIAHYPPTVQAGEATKIVEQLADYLIGVQY
SIO_010081: YOR122C
subclass of: SO_0000673
so part of: YOR122C
location: complement(join(552298..552665,552875..552887))
location: region:552298-552887:-1
so has part: feature:552875-552887:-1:exon
so has part: feature:552298-552665:-1:exon

NP_014765.3
type: Protein
SIO_000068: ncbiprotein

S000005648
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552875-552887:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:552298-552665:-1:exon

YOR123C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LEO1
locus tag: YOR123C
so part of: sequence
location: complement(<553176..>554570)
location: region:553176-554570:-1
so has part: feature:553176-554570:-1:exon
subclass of: SO_0000010

854290
type: Gene
SIO_000068: ncbigene

position:553176:-1
position: 553176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:554570:-1
position: 554570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553176-554570:-1:exon

YOR123C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LEO1
locus tag: YOR123C
product: Leo1p
transcript id: NM_001183542.1
SIO_010081: YOR123C
subclass of: SO_0000673
so part of: YOR123C
location: complement(<553176..>554570)
location: region:553176-554570:-1
so has part: feature:553176-554570:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:553176-554570:-1:exon

YOR123C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LEO1
locus tag: YOR123C
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20732871]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643076]
experiment: EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]
experiment: EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11927560]
experiment: EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:20732871]
experiment: EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]
experiment: EXISTENCE:physical interaction:GO:0003712 transcription coregulator activity [PMID:11927560]
experiment: EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11927560|PMID:11884586]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11927560]
note: Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
codon start: 1
product: Leo1p
translation: MSSESPQDQPQKEQISNNVGVTTNSTSNEETSRSQDDNVKEVNGNDDTKEEEQEEDAELDDLFGDDNDDDDDDDVKKSETEKSDSDSDEDDEGENINHRSRHRESLGLDDDEAEEQAMYTRKFYGEDANNFSDQDETTHTFKEENVELVRHIIPSKANVNETASHNEIFYARIPNFLTIDPIPFDPPSFEAKVNERASNSASREDQLDDRLIDENTVRWRYSRDKDQHVFKESNTQIVQWSDGTYSLKVGEECTDILVNDTSNTFLTVSHDQQELIQCYEGGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMDPEVEKKELERKQSQILRDRRRRQLKEKEKQESPDAAFETGFRKQNSPTTYGASRRNEYEEDDFLVDDDEEEEAAFDDEEDDNEEEEEEEDADEENASRLRNLKREGAAMYREEEEEEKDRSETKRRRVAVIEDDEDED
SIO_010081: YOR123C
subclass of: SO_0000673
so part of: YOR123C
location: complement(553176..554570)
location: region:553176-554570:-1
so has part: feature:553176-554570:-1:exon

NP_014766.1
type: Protein
SIO_000068: ncbiprotein

S000005649
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:553176-554570:-1:exon

YOR124C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBP2
locus tag: YOR124C
so part of: sequence
location: complement(<554824..>558642)
location: region:554824-558642:-1
so has part: feature:554824-558642:-1:exon
subclass of: SO_0000010

854291
type: Gene
SIO_000068: ncbigene

position:554824:-1
position: 554824
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558642:-1
position: 558642
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554824-558642:-1:exon

YOR124C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBP2
locus tag: YOR124C
product: ubiquitin-specific protease UBP2
transcript id: NM_001183543.3
SIO_010081: YOR124C
subclass of: SO_0000673
so part of: YOR124C
location: complement(<554824..>558642)
location: region:554824-558642:-1
so has part: feature:554824-558642:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554824-558642:-1:exon

YOR124C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBP2
locus tag: YOR124C
EC number: 3.4.19.12
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680|PMID:24069405]
experiment: EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:15933713|PMID:24069405]
experiment: EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:24069405]
experiment: EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:23317502]
experiment: EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:25622294]
experiment: EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:24069405|PMID:23317502]
experiment: EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:19165343]
note: Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
codon start: 1
product: ubiquitin-specific protease UBP2
translation: MPNEDNELQKAIENHHNQLLNQDKENADRNGSVIEDLPLYGTSINQQSTPGDVDDGKHLLYPDIATNLPLKTSDRLLDDILCDTIFLNSTDPKVMQKGLQSRGILKESMLSYSTFRSSIRPNCLGSLTDQVVFQTKSEYDSISCPKYNKIHVFQAVIFNPSLAEQQISTFDDIVKIPIYHLKVSVKVRQELERLKKHVGVTQFHSLDHLHEYDRVDLSTFDSSDPNLLDYGIYVSDDTNKLILIEIFKPEFNSPEEHESFTADAIKKRYNAMCVKNESLDKSETPSQVDCFYTLFKIFKGPLTRKSKAEPTKTIDSGNLALNTHLNPEWLTSKYGFQASSEIDEETNEIFTEYVPPDMVDYVNDLETRKIRESFVRKCLQLIFWGQLSTSLLAPNSPLKNTKSVKGMSSLQTSFSTLPWFHLLGESRARILLNSNEQTHSPLDAEPHFINLSVSHYYTDRDIIRNYESLSSLDPENIGLYFDALTYIANRKGAYQLIAYCGKQDIIGQEALENALLMFKINPKECNISELNEATLLSIYKYETSNKSQVTSNHLTNLKNALRLLAKYTKSDKLKFYVDHEPYRALSQAYDTLSIDESVDEDIIKTAYSVKINDSPGLKLDCDRALYTIAISKRSLDLFNFLTEECPQFSNYYGPEKLDYQEALKLLQVNENASDETILKIFKQKWFDENVYEPDQFLILRAALTKISIERNSTLITNFLLTGTIDPNSLPPENWPTGINNIGNTCYLNSLLQYYFSIAPLRRYVLEYQKTVENFNDHLSNSGHIRRIGGREISRGEVERSIQFIYQLRNLFYAMVHTRERCVTPSKELAYLAFAPSNVEVEFEVEGNKVVDQTGVLSDSKKETTDDAFTTKIKDTSLIDLEMEDGLNGDVGTDANRKKNESNDAEVSENEDTTGLTSPTRVAKISSDQLENALEMGRQQDVTECIGNVLFQIESGSEPIRYDEDNEQYDLVKQLFYGTTKQSIVPLSATNKVRTKVERFLSLLINIGDHPKDIYDAFDSYFKDEYLTMEEYGDVIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRYADTENPLLLAKKKETEEMKQKLKVMKNRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTPLKIEAANDVIKTLRNNVQNIDNELMKLYNDINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYGHYWIYIKDRNRNGIWRKYNDETISEVQEEEVFNFNEGNTATPYFLVYVKQGQEGDIEPLKRILK
SIO_010081: YOR124C
subclass of: SO_0000673
so part of: YOR124C
location: complement(554824..558642)
location: region:554824-558642:-1
so has part: feature:554824-558642:-1:exon

NP_014767.3
type: Protein
SIO_000068: ncbiprotein

S000005650
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554824-558642:-1:exon

YOR125C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COQ7
gene: CAT5
locus tag: YOR125C
gene synonym: COQ7
so part of: sequence
location: complement(<559030..>559731)
location: region:559030-559731:-1
so has part: feature:559030-559731:-1:exon
subclass of: SO_0000010

854292
type: Gene
SIO_000068: ncbigene

position:559030:-1
position: 559030
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:559731:-1
position: 559731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559030-559731:-1:exon

YOR125C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COQ7
gene: CAT5
locus tag: YOR125C
gene synonym: COQ7
product: putative monooxygenase CAT5
transcript id: NM_001183544.1
SIO_010081: YOR125C
subclass of: SO_0000673
so part of: YOR125C
location: complement(<559030..>559731)
location: region:559030-559731:-1
so has part: feature:559030-559731:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559030-559731:-1:exon

YOR125C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COQ7
gene: CAT5
locus tag: YOR125C
gene synonym: COQ7
EC number: 1.14.99.60
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9452453]
experiment: EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9452453]
note: Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
codon start: 1
product: putative monooxygenase CAT5
translation: MLSRVSVFKPASRGFSVLSSLKITEHTSAKHTEKPEHAPKCQNLSDAQAAFLDRVIRVDQAGELGADYIYAGQYFVLAHRYPHLKPVLKHIWDQEIHHHNTFNNLQLKRRVRPSLLTPLWKAGAFAMGAGTALISPEAAMACTEAVETVIGGHYNGQLRNLANQFNLERTDGTKGPSEEIKSLTSTIQQFRDDELEHLDTAIKHDSYMAVPYTVITEGIKTICRVAIWSAERI
SIO_010081: YOR125C
subclass of: SO_0000673
so part of: YOR125C
location: complement(559030..559731)
location: region:559030-559731:-1
so has part: feature:559030-559731:-1:exon

NP_014768.2
type: Protein
SIO_000068: ncbiprotein

S000005651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559030-559731:-1:exon

YOR126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IAH1
locus tag: YOR126C
so part of: sequence
location: complement(<559961..>560677)
location: region:559961-560677:-1
so has part: feature:559961-560677:-1:exon
subclass of: SO_0000010

854293
type: Gene
SIO_000068: ncbigene

position:559961:-1
position: 559961
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560677:-1
position: 560677
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559961-560677:-1:exon

YOR126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IAH1
locus tag: YOR126C
product: isoamyl acetate-hydrolyzing esterase
transcript id: NM_001183545.3
SIO_010081: YOR126C
subclass of: SO_0000673
so part of: YOR126C
location: complement(<559961..>560677)
location: region:559961-560677:-1
so has part: feature:559961-560677:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559961-560677:-1:exon

YOR126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IAH1
locus tag: YOR126C
EC number: 3.1.1.112
experiment: EXISTENCE:direct assay:GO:0006083 acetate metabolic process [PMID:10855721]
experiment: EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:10855721]
note: Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
codon start: 1
product: isoamyl acetate-hydrolyzing esterase
translation: MDYEKFLLFGDSITEFAFNTRPIEDGKDQYALGAALVNEYTRKMDILQRGFKGYTSRWALKILPEILKHESNIVMATIFLGANDACSAGPQSVPLPEFIDNIRQMVSLMKSYHIRPIIIGPGLVDREKWEKEKSEEIALGYFRTNENFAIYSDALAKLANEEKVPFVALNKAFQQEGGDAWQQLLTDGLHFSGKGYKIFHDELLKVIETFYPQYHPKNMQYKLKDWRDVLDDGSNIMS
SIO_010081: YOR126C
subclass of: SO_0000673
so part of: YOR126C
location: complement(559961..560677)
location: region:559961-560677:-1
so has part: feature:559961-560677:-1:exon

NP_014769.3
type: Protein
SIO_000068: ncbiprotein

S000005652
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559961-560677:-1:exon

YOR127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DBM1
alternative label: THE1
gene: RGA1
locus tag: YOR127W
gene synonym: DBM1; THE1
so part of: sequence
location: <561170..>564193
location: region:561170-564193:1
so has part: feature:561170-564193:1:exon
subclass of: SO_0000010

854294
type: Gene
SIO_000068: ncbigene

position:561170:1
position: 561170
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:564193:1
position: 564193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561170-564193:1:exon

YOR127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DBM1
alternative label: THE1
gene: RGA1
locus tag: YOR127W
gene synonym: DBM1; THE1
product: GTPase-activating protein RGA1
transcript id: NM_001183546.1
SIO_010081: YOR127W
subclass of: SO_0000673
so part of: YOR127W
location: <561170..>564193
location: region:561170-564193:1
so has part: feature:561170-564193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:561170-564193:1:exon

YOR127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DBM1
alternative label: THE1
gene: RGA1
locus tag: YOR127W
gene synonym: DBM1; THE1
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12455995|PMID:17981141|PMID:18166650|PMID:7498791]
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:29074565]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:18166650]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:12455995]
experiment: EXISTENCE:direct assay:GO:0071597 cellular birth scar [PMID:29074565]
experiment: EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:7498791]
experiment: EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:7498791]
experiment: EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:14517318]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:8657111]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:18166650]
experiment: EXISTENCE:physical interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:7498791]
experiment: EXISTENCE:physical interaction:GO:0007118 budding cell apical bud growth [PMID:7498791]
experiment: EXISTENCE:physical interaction:GO:0007119 budding cell isotropic bud growth [PMID:7498791]
experiment: EXISTENCE:physical interaction:GO:2000222 positive regulation of pseudohyphal growth [PMID:7498791]
note: GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain
codon start: 1
product: GTPase-activating protein RGA1
translation: MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT
SIO_010081: YOR127W
subclass of: SO_0000673
so part of: YOR127W
location: 561170..564193
location: region:561170-564193:1
so has part: feature:561170-564193:1:exon

NP_014770.1
type: Protein
SIO_000068: ncbiprotein

S000005653
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:561170-564193:1:exon

YOR128C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADE2
locus tag: YOR128C
so part of: sequence
location: complement(<564476..>566191)
location: region:564476-566191:-1
so has part: feature:564476-566191:-1:exon
subclass of: SO_0000010

854295
type: Gene
SIO_000068: ncbigene

position:564476:-1
position: 564476
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:566191:-1
position: 566191
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:564476-566191:-1:exon

YOR128C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADE2
locus tag: YOR128C
product: phosphoribosylaminoimidazole carboxylase ADE2
transcript id: NM_001183547.3
SIO_010081: YOR128C
subclass of: SO_0000673
so part of: YOR128C
location: complement(<564476..>566191)
location: region:564476-566191:-1
so has part: feature:564476-566191:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:564476-566191:-1:exon

YOR128C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADE2
locus tag: YOR128C
EC number: 4.1.1.21
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004638 phosphoribosylaminoimidazole carboxylase activity [PMID:5767024]
experiment: EXISTENCE:mutant phenotype:GO:0006144 purine nucleobase metabolic process [PMID:8939809]
note: Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
codon start: 1
product: phosphoribosylaminoimidazole carboxylase ADE2
translation: MDSRTVGILGGGQLGRMIVEAANRLNIKTVILDAENSPAKQISNSNDHVNGSFSNPLDIEKLAEKCDVLTIEIEHVDVPTLKNLQVKHPKLKIYPSPETIRLIQDKYIQKEHLIKNGIAVTQSVPVEQASETSLLNVGRDLGFPFVLKSRTLAYDGRGNFVVKNKEMIPEALEVLKDRPLYAEKWAPFTKELAVMIVRSVNGLVFSYPIVETIHKDNICDLCYAPARVPDSVQLKAKLLAENAIKSFPGCGIFGVEMFYLETGELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKNFTSFSTITTNAIMLNVLGDKHTKDKELETCERALATPGSSVYLYGKESRPNRKVGHINIIASSMAECEQRLNYITGRTDIPIKISVAQKLDLEAMVKPLVGIIMGSDSDLPVMSAACAVLKDFGVPFEVTIVSAHRTPHRMSAYAISASKRGIKTIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSCLDGVDSLHSIVQMPRGVPVATVAINNSTNAALLAVRLLGAYDSSYTTKMEQFLLKQEEEVLVKAQKLETVGYEAYLENK
SIO_010081: YOR128C
subclass of: SO_0000673
so part of: YOR128C
location: complement(564476..566191)
location: region:564476-566191:-1
so has part: feature:564476-566191:-1:exon

NP_014771.3
type: Protein
SIO_000068: ncbiprotein

S000005654
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:564476-566191:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1516; Autonomously Replicating Sequence
so part of: sequence
location: 566410..566643
location: region:566410-566643:1
so has part: feature:566410-566643:1:region

S000114843
type: SGD
SIO_000068: sgd

position:566410:1
position: 566410
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:566643:1
position: 566643
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566410-566643:1:region

YOR129C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AFI1
locus tag: YOR129C
so part of: sequence
location: complement(<566877..>569558)
location: region:566877-569558:-1
so has part: feature:566877-569558:-1:exon
subclass of: SO_0000010

854296
type: Gene
SIO_000068: ncbigene

position:566877:-1
position: 566877
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:569558:-1
position: 569558
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566877-569558:-1:exon

YOR129C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AFI1
locus tag: YOR129C
product: Afi1p
transcript id: NM_001183548.1
SIO_010081: YOR129C
subclass of: SO_0000673
so part of: YOR129C
location: complement(<566877..>569558)
location: region:566877-569558:-1
so has part: feature:566877-569558:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:566877-569558:-1:exon

YOR129C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AFI1
locus tag: YOR129C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18397879]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:18397879]
experiment: EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18397879]
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:18397879]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:14515169]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:14515169|PMID:18397879]
experiment: EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18397879]
note: Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p
codon start: 1
product: Afi1p
translation: MLRRELNNSISNRSIENESFPFERPNVSYIISAEFDNKLGPILKHQYPKDIPGFNQFSHEQRNGNTSVSMNLASLMIPSSIERNPGKQDITVFTLYYNKFTQNYQLFPVPKDPRFSFNLHHREQSDGSVTNSIYYDAENHQDAKNNRYTIVLEDDELECQEVQNNQKAIDNEPLFFINVANTVLDTTNDRGAVIKSIAIGTPLKTFFAFKNIIVLVLDLYMKAPTQAAATDILLDCFNMLNSIDLTLINDIHSKSSIQEVLHSIHDESIITKVFLDPDSTLKKLFCINGFDTKDKYGNIVTFHDQLIQYHFTRFQPKTLPPFLLKIPLQFNMIRREPIYIENDYNELVLKFLDKFVPYLLKAGQKVNAWKLVINSTKLSKEDLCAFILSLANITATYASDPQSYFKGNAALIFPYMDISLVDGLRAYVASNSDFVGCFAIIGTANPIFRYQLDIWDYYYDVDEGVFYENNSPEKEKPDTVAEVKIGPNPLRKIFNRPHFSTNAVNESQVNLGQKLFSLLIDEYHDSDTIMSVLRRLNVLQLENLLDALKRREIPPNIALKDEYIMFYKDFFIFPEFFDYFTLHSIELLSNLDNCLFSLGNTCQLFSTEQIYSQLSQILDIVKELFRMVSVSRTNIEKFLNACLNYSPFKILPTAQLHGDNISRWSFESEVRQGFDNFNSYMGIEKDPHGVIVSAIDLFTQIYSFDILAFFLTFITKESGQDLPFTKSLSRRRTYLTRIAQSSSLRQFLQLSTRPNIRILGGNGQGTGNSNYPEFTNASSVISPKLRASPLLERRASKICYAITKLLYRLECHPIGMALLKKYLHNQLREAYLESKRHFISKKGDSTNTSSTIASSSFAGASVPLSSNESGMLNGLKQINEQQESTLETTQKED
SIO_010081: YOR129C
subclass of: SO_0000673
so part of: YOR129C
location: complement(566877..569558)
location: region:566877-569558:-1
so has part: feature:566877-569558:-1:exon

NP_014772.1
type: Protein
SIO_000068: ncbiprotein

S000005655
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566877-569558:-1:exon

YOR130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARG11
gene: ORT1
locus tag: YOR130C
gene synonym: ARG11
so part of: sequence
location: complement(<569929..>570807)
location: region:569929-570807:-1
so has part: feature:569929-570807:-1:exon
subclass of: SO_0000010

854297
type: Gene
SIO_000068: ncbigene

position:569929:-1
position: 569929
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:570807:-1
position: 570807
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569929-570807:-1:exon

YOR130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARG11
gene: ORT1
locus tag: YOR130C
gene synonym: ARG11
product: Ort1p
transcript id: NM_001183549.4
SIO_010081: YOR130C
subclass of: SO_0000673
so part of: YOR130C
location: complement(<569929..>570807)
location: region:569929-570807:-1
so has part: feature:569929-570807:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:569929-570807:-1:exon

YOR130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARG11
gene: ORT1
locus tag: YOR130C
gene synonym: ARG11
experiment: EXISTENCE:direct assay:GO:0000064 L-ornithine transmembrane transporter activity [PMID:9237680]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:8798783]
experiment: EXISTENCE:direct assay:GO:1990575 mitochondrial L-ornithine transmembrane transport [PMID:9237680]
experiment: EXISTENCE:mutant phenotype:GO:0006526 arginine biosynthetic process [PMID:8798783]
note: Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement
codon start: 1
product: Ort1p
translation: MEDSKKKGLIEGAILDIINGSIAGACGKVIEFPFDTVKVRLQTQASNVFPTTWSCIKFTYQNEGIARGFFQGIASPLVGACLENATLFVSYNQCSKFLEKHTNVSPLGQILISGGVAGSCASLVLTPVELVKCKLQVANLQVASAKTKHTKVLPTIKAIITERGLAGLWQGQSGTFIRESFGGVAWFATYEIVKKSLKDRHSLDDPKRDESKIWELLISGGSAGLAFNASIFPADTVKSVMQTEHISLTNAVKKIFGKFGLKGFYRGLGITLFRAVPANAAVFYIFETLSAL
SIO_010081: YOR130C
subclass of: SO_0000673
so part of: YOR130C
location: complement(569929..570807)
location: region:569929-570807:-1
so has part: feature:569929-570807:-1:exon

NP_014773.4
type: Protein
SIO_000068: ncbiprotein

S000005656
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:569929-570807:-1:exon

YNCO0019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0019W
so part of: sequence
location: 571958..572029
location: region:571958-572029:1
so has part: feature:571958-572029:1:exon
subclass of: SO_0000663

854298
type: Gene
SIO_000068: ncbigene

position:571958:1
position: 571958
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:572029:1
position: 572029
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:571958-572029:1:exon

YNCO0019W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0019W
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0019W
subclass of: SO_0000673
so part of: YNCO0019W
location: 571958..572029
location: region:571958-572029:1
so has part: feature:571958-572029:1:exon

S000006545
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:571958-572029:1:exon

YOR131C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR131C
so part of: sequence
location: complement(<572182..>572838)
location: region:572182-572838:-1
so has part: feature:572182-572838:-1:exon
subclass of: SO_0000010

854299
type: Gene
SIO_000068: ncbigene

position:572182:-1
position: 572182
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:572838:-1
position: 572838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:572182-572838:-1:exon

YOR131C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR131C
product: putative haloacid dehalogenase-like hydrolase
transcript id: NM_001183550.1
SIO_010081: YOR131C
subclass of: SO_0000673
so part of: YOR131C
location: complement(<572182..>572838)
location: region:572182-572838:-1
so has part: feature:572182-572838:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:572182-572838:-1:exon

YOR131C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR131C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0033883 pyridoxal phosphatase activity [PMID:26071590]
note: Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative haloacid dehalogenase-like hydrolase
translation: MTKLQGLQGLKHIKAVVFDMDGTLCLPQPWMFPAMRNAIGLEDKSIDILHFIDTLPTEKEKKEAHDRIELVEAKAMKEMQPQPGLVDIMRYLTKNGISKNICTRNVGAPVETFVKRFIPSELSRFDYIVTREFRPTKPQPDPLLHIASKLNIRPLEMIMVGDSFDDMKSGRSAGCFTVLLKNHVNGHLLLEHKELVDVSVEDLSEIIELIQNMNKESF
SIO_010081: YOR131C
subclass of: SO_0000673
so part of: YOR131C
location: complement(572182..572838)
location: region:572182-572838:-1
so has part: feature:572182-572838:-1:exon

NP_014774.1
type: Protein
SIO_000068: ncbiprotein

S000005657
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:572182-572838:-1:exon

YOR132W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PEP21
alternative label: VPT3
gene: VPS17
locus tag: YOR132W
gene synonym: PEP21; VPT3
so part of: sequence
location: <573175..>574830
location: region:573175-574830:1
so has part: feature:573175-574830:1:exon
subclass of: SO_0000010

854300
type: Gene
SIO_000068: ncbigene

position:573175:1
position: 573175
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:574830:1
position: 574830
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:573175-574830:1:exon

YOR132W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PEP21
alternative label: VPT3
gene: VPS17
locus tag: YOR132W
gene synonym: PEP21; VPT3
product: retromer subunit VPS17
transcript id: NM_001183551.3
SIO_010081: YOR132W
subclass of: SO_0000673
so part of: YOR132W
location: <573175..>574830
location: region:573175-574830:1
so has part: feature:573175-574830:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:573175-574830:1:exon

YOR132W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PEP21
alternative label: VPT3
gene: VPS17
locus tag: YOR132W
gene synonym: PEP21; VPT3
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030905 retromer, tubulation complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0140318 protein transporter activity [PMID:9700157]
note: Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes
codon start: 1
product: retromer subunit VPS17
translation: MTSAVPYDPYDDLDNNPFAEPQEEDSEPAATTTDGSSSMSEERVGTEQTAASVQDNGTANNIQNGLGEEGNATRSKTSNEHNENQQPSQPSERVILPERSDEKKKYTLLAKVTGLERFGSATGKKENPTIIFDCSTNLPTFRKQQYKNVKKSYEEFHQLFKYLNVAIQESFVPTLPSAYTTFGINSEEDRMKVTRNFQLWFNRLSQDPLIIRNEEVAFFIESDFNTYTPINKSKSLASGLKRKTLKQLAPPYDEITELAEFRPLVKSIYVVSQSLQEKLLRVSRNRKMMVQEENAFGQDFVNLDEHNKLYRRYGKILTAVGDIDSIIATMDMATLYDGLEWIVRDAYAVKEALTNRHFIMRNLVQAQQNSKAKQEQARRFRSRRDINPMKIDEALRQLKAAAKNEQVLTLKLQRITSNMIIERKQWISWYEEWIRSSIKEFTLRKIEYERKKLTLLERVRSDIRKADENGGLSRLGRHAVSNNNSDTSQTLKGDSWTGESNRKSQIPINKIAHTEFDDELFTEDDGYNSQDSDTTSLNARHAASLLGMSTK
SIO_010081: YOR132W
subclass of: SO_0000673
so part of: YOR132W
location: 573175..574830
location: region:573175-574830:1
so has part: feature:573175-574830:1:exon

NP_014775.3
type: Protein
SIO_000068: ncbiprotein

S000005658
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:573175-574830:1:exon

YOR133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EFT1
locus tag: YOR133W
so part of: sequence
location: <575098..>577626
location: region:575098-577626:1
so has part: feature:575098-577626:1:exon
subclass of: SO_0000010

854301
type: Gene
SIO_000068: ncbigene

position:575098:1
position: 575098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:577626:1
position: 577626
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575098-577626:1:exon

YOR133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EFT1
locus tag: YOR133W
product: elongation factor 2
transcript id: NM_001183552.1
SIO_010081: YOR133W
subclass of: SO_0000673
so part of: YOR133W
location: <575098..>577626
location: region:575098-577626:1
so has part: feature:575098-577626:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:575098-577626:1:exon

YOR133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EFT1
locus tag: YOR133W
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16950777]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:10835368|PMID:16950777]
experiment: EXISTENCE:direct assay:GO:0051087 chaperone binding [PMID:30876804]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:16950777]
experiment: EXISTENCE:mutant phenotype:GO:0045901 positive regulation of translational elongation [PMID:19338753]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:16950777]
note: Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
codon start: 1
product: elongation factor 2
translation: MVAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYDKL
SIO_010081: YOR133W
subclass of: SO_0000673
so part of: YOR133W
location: 575098..577626
location: region:575098-577626:1
so has part: feature:575098-577626:1:exon

NP_014776.1
type: Protein
SIO_000068: ncbiprotein

S000005659
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:575098-577626:1:exon

YOR134W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BAG7
locus tag: YOR134W
so part of: sequence
location: <578564..>579793
location: region:578564-579793:1
so has part: feature:578564-579793:1:exon
subclass of: SO_0000010

854302
type: Gene
SIO_000068: ncbigene

position:578564:1
position: 578564
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:579793:1
position: 579793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578564-579793:1:exon

YOR134W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BAG7
locus tag: YOR134W
product: GTPase-activating protein BAG7
transcript id: NM_001183553.3
SIO_010081: YOR134W
subclass of: SO_0000673
so part of: YOR134W
location: <578564..>579793
location: region:578564-579793:1
so has part: feature:578564-579793:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:578564-579793:1:exon

YOR134W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BAG7
locus tag: YOR134W
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12207708|PMID:11591390]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:11591390|PMID:12207708]
experiment: EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:12207708]
note: Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication
codon start: 1
product: GTPase-activating protein BAG7
translation: MFNMNLLSTPSSEEGSPQNRSSSMSSVEGKKDRDTFTNLQNEFDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGKYLKENALDTTGIFRIAGSNKRVRELQAVFSKPPDYGRKFEGWCDFNVHDIATLLKRYLNSLSEPLVPLALYDIFRNPILENPKINEHKEQIIKDYEDIYMLLPQQNRHLILYLAALLNLFARNEKKNLMSASNLAAIVQPSLLSHPKDEMCPKEYEASRTVIEFLILHASDIIPNTEKANKDTMPHAGTVAKFNNITVPEMAIDSDEEDFVHPSIDDHMLPRSRALSDSNNFTIHHHHHHHHALFPSPIDFDNNGLSVPRSFKGRTLSAESLSPRLSKLLGNVGNSSNTGIKDPTERVPRGEHKTKHKQRQSWLRRLTSPSRTQP
SIO_010081: YOR134W
subclass of: SO_0000673
so part of: YOR134W
location: 578564..579793
location: region:578564-579793:1
so has part: feature:578564-579793:1:exon

NP_014777.3
type: Protein
SIO_000068: ncbiprotein

S000005660
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578564-579793:1:exon

YOR136W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IDH2
locus tag: YOR136W
so part of: sequence
location: <580250..>581359
location: region:580250-581359:1
so has part: feature:580250-581359:1:exon
subclass of: SO_0000010

854303
type: Gene
SIO_000068: ncbigene

position:580250:1
position: 580250
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:581359:1
position: 581359
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:580250-581359:1:exon

YOR136W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IDH2
locus tag: YOR136W
product: isocitrate dehydrogenase (NAD(+)) IDH2
transcript id: NM_001183555.1
SIO_010081: YOR136W
subclass of: SO_0000673
so part of: YOR136W
location: <580250..>581359
location: region:580250-581359:1
so has part: feature:580250-581359:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:580250-581359:1:exon

YOR136W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IDH2
locus tag: YOR136W
EC number: 1.1.1.41
experiment: EXISTENCE:direct assay:GO:0004449 isocitrate dehydrogenase (NAD+) activity [PMID:16884682]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:11914276|PMID:16823961|PMID:14576278|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+) [PMID:16884682]
experiment: EXISTENCE:direct assay:GO:0006102 isocitrate metabolic process [PMID:16884682]
note: Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes oxidation of isocitrate to alpha-ketoglutarate in TCA cycle; targeted to vacuole via AP-3 pathway
codon start: 1
product: isocitrate dehydrogenase (NAD(+)) IDH2
translation: MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL
SIO_010081: YOR136W
subclass of: SO_0000673
so part of: YOR136W
location: 580250..581359
location: region:580250-581359:1
so has part: feature:580250-581359:1:exon

NP_014779.1
type: Protein
SIO_000068: ncbiprotein

S000005662
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:580250-581359:1:exon

YOR137C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SIA1
locus tag: YOR137C
so part of: sequence
location: complement(<581813..>583681)
location: region:581813-583681:-1
so has part: feature:581813-583681:-1:exon
subclass of: SO_0000010

854305
type: Gene
SIO_000068: ncbigene

position:581813:-1
position: 581813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583681:-1
position: 583681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581813-583681:-1:exon

YOR137C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SIA1
locus tag: YOR137C
product: Sia1p
transcript id: NM_001183556.3
SIO_010081: YOR137C
subclass of: SO_0000673
so part of: YOR137C
location: complement(<581813..>583681)
location: region:581813-583681:-1
so has part: feature:581813-583681:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:581813-583681:-1:exon

YOR137C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SIA1
locus tag: YOR137C
experiment: EXISTENCE:mutant phenotype:GO:1902600 proton transmembrane transport [PMID:9450541]
note: Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization
codon start: 1
product: Sia1p
translation: MRLHYRRRFNFLRRILFILCITSLYLSRDSLKLHAKNVLMDHNVAEYHGGMIDDIQILRCYHWYRQCSSLYAPKLHPSNTAKKIKDKNSILWTRVSKNITVETLYSLQSGPFYNSYLYVHLKDFQSNPKNTIKELAIARDSALIPLQVLRDINKLVKSSDSSVFHNHVYLREKPTSSWWKLLFGISVDTDNIAVFGEEWVYKGSGIWCKYILNDDDNDAPITNLEIYLGSSFIESRPSWKEVIHEFHRNNIPSLPISITRKLETKNHHHKFSNGLLGSLRTPSKDINIQVDADYKITSPHIQFSRGQRSFKILQITDFHFKCTDNSMTVINEIKTVNFIDRVLASENPDLVVITGDLLDSHNTIDYQTCIMKVVQPMISNKIPYAISLGVSDESNLATSAQIRDFIRNLPYTFNNVASEEGHMAIEVSFKKKLTKNTLLERDIDTEDETNPSEALFFVFDSFAPVNNFLQDYNDLIGKIDFGLAFQYFPLSEYRPHGLFPIIGQYNERSTLTVDTPRSRGQVSMTINGKHYKSFLDILSLWNIKGVSCGHEHNNDCCLQSKNEMWLCYGGSAGIGLPRIQGIYPTVRLFNLDDILDEITSWKRNSNLVDEVYDYQYIYKGKQ
SIO_010081: YOR137C
subclass of: SO_0000673
so part of: YOR137C
location: complement(581813..583681)
location: region:581813-583681:-1
so has part: feature:581813-583681:-1:exon

NP_014780.3
type: Protein
SIO_000068: ncbiprotein

S000005663
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:581813-583681:-1:exon

YOR138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RUP1
locus tag: YOR138C
so part of: sequence
location: complement(<584309..>586324)
location: region:584309-586324:-1
so has part: feature:584309-586324:-1:exon
subclass of: SO_0000010

854306
type: Gene
SIO_000068: ncbigene

position:584309:-1
position: 584309
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:586324:-1
position: 586324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584309-586324:-1:exon

YOR138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RUP1
locus tag: YOR138C
product: Rup1p
transcript id: NM_001183557.1
SIO_010081: YOR138C
subclass of: SO_0000673
so part of: YOR138C
location: complement(<584309..>586324)
location: region:584309-586324:-1
so has part: feature:584309-586324:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584309-586324:-1:exon

YOR138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RUP1
locus tag: YOR138C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:24069405]
experiment: EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:15933713]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15933713]
note: Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Rup1p
translation: MMDNQAVKSLLEMGIPHEVAVDALQRTGGNLEAAVNFIFSNELPEQAEMGEENDGSQPRISENKIVAGTKPCDVPNNGDQDIDMPDVSGVDVDYDDDEDITDERSGSNSTSGCRVTAQNYDRYSISETSIPPPSYSIVQHNEFKSNVGDPTVVLPLPLNSLIESYFGLFALLTAVYFPHVFLKPDFKDLNYRADWFKGSSFTEPKYRLAYCEAEDGSTTSEIVLASGPNEGLQPHLLWQLQKLISVVNTRKCERAFVSAKVFTSSLEPQLRSKLADSEHLYEVLPAFIKSLAVDLEMCPGIRDRETRSLFISSALHTPNKNEPPMETFLSLFHFLPEEYDSNLYKMFNVLLYPEEEEEEEDVIRGGEQEEARYVEPENTLKEVAPVLTILFNELETNTESVSLPNGVDIPLEFYPQLYTKQCKDQLIRHIISKRKQARTRSRCLLQEINELKSYQGKNISTILESTLAYLQTIPDDANNEAAKQIASLKDTLNSARAAKMEEYKDLASKLHGEWNLSHPETHIINTAKQLGLIENPYILTMAALSPYSYFIRSRNGAWSWIQSNTLGTEFKVKKCSSPSVVQEAIKHGTKYASETPLMFIYCEEGKIPTEEVVAEALKSNSGCLKFAEDDQNSLKTLRSQFFDGMGDPEQATNNINNGNDNDNDDDIDSDN
SIO_010081: YOR138C
subclass of: SO_0000673
so part of: YOR138C
location: complement(584309..586324)
location: region:584309-586324:-1
so has part: feature:584309-586324:-1:exon

NP_014781.1
type: Protein
SIO_000068: ncbiprotein

S000005664
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584309-586324:-1:exon

YOR140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SFL1
locus tag: YOR140W
so part of: sequence
location: <586981..>589281
location: region:586981-589281:1
so has part: feature:586981-589281:1:exon
subclass of: SO_0000010

854307
type: Gene
SIO_000068: ncbigene

position:586981:1
position: 586981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:589281:1
position: 589281
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586981-589281:1:exon

YOR140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SFL1
locus tag: YOR140W
product: Sfl1p
transcript id: NM_001183559.4
SIO_010081: YOR140W
subclass of: SO_0000673
so part of: YOR140W
location: <586981..>589281
location: region:586981-589281:1
so has part: feature:586981-589281:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:586981-589281:1:exon

YOR140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SFL1
locus tag: YOR140W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11399075|PMID:12024012|PMID:9755175]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12024012]
experiment: EXISTENCE:direct assay:GO:0010508 positive regulation of autophagy [PMID:26649943]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:27336723]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26649943]
experiment: EXISTENCE:direct assay:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:26649943]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9811878]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12024012|PMID:15466424|PMID:9811878]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27336723|PMID:17594096]
experiment: EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9755175|PMID:11399075]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11399075]
note: Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)
codon start: 1
product: Sfl1p
translation: MSEEETVSAPAPASTPAPAGTDVGSGGAAAGIANAGAEGGDGAEDVKKHGSKMLVGPRPPQNAIFIHKLYQILEDESLHDLIWWTPSGLSFMIKPVERFSKALATYFKHTNITSFVRQLNIYGFHKVSHDHSSNDANSGDDANTNDDSNTHDDNSGNKNSSGDENTGGGVQEKEKSNPTKIWEFKHSSGIFKKGDIEGLKHIKRRASSRNNSSINSRKNSSNQNYDIDSGARVRPSSIQDPSTSSNSFGNFVPQIPGANNSIPEYFNNSHVTYENANHAPLESNNPEMQEQNRPPNFQDETLKHLKEINFDMVKIIESMQHFISLQHSFCSQSFTFKNVSKKKSENIVKDHQKQLQAFESDMLTFKQHVMSRAHRTIDSLCAVNAAATAASVAPAPAPTSTSAYAPKSQYEMMVPPGNQYVPQKSSSTTNIPSRFNTASVPPSQLFVQYQPQSQQHVTYAKQPAHVPNFINQPIPIQQLPPQYADTFSTPQMMHNPFASKNNNKPGNTKRTNSVLMDPLTPAASVGVQGPLNYPIMNINPSVRDYNKPVPQNMAPSPIYPINEPTTRLYSQPKMRSLGSTSSLPNDRRNSPLKLTPRSSLNEDSLYPKPRNSLKSSISGTSLSSSFTLVANNPAPIRYSQQGLLRSLNKAANCAPDSVTPLDSSVLTGPPPKNMDNLPAVSSNLINSPMNVEHSSSLSQAEPAPQIELPQPSLPTTSTTKNTGEADNSKRKGSGVYSLLNQEDSSTSSADPKTEDKAAPALKKVKM
SIO_010081: YOR140W
subclass of: SO_0000673
so part of: YOR140W
location: 586981..589281
location: region:586981-589281:1
so has part: feature:586981-589281:1:exon

NP_014783.4
type: Protein
SIO_000068: ncbiprotein

S000005666
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586981-589281:1:exon

YOR141C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARP8
locus tag: YOR141C
so part of: sequence
location: complement(<589942..>592587)
location: region:589942-592587:-1
so has part: feature:589942-592587:-1:exon
subclass of: SO_0000010

854309
type: Gene
SIO_000068: ncbigene

position:589942:-1
position: 589942
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592587:-1
position: 592587
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:589942-592587:-1:exon

YOR141C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARP8
locus tag: YOR141C
product: Arp8p
transcript id: NM_001183560.1
SIO_010081: YOR141C
subclass of: SO_0000673
so part of: YOR141C
location: complement(<589942..>592587)
location: region:589942-592587:-1
so has part: feature:589942-592587:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:589942-592587:-1:exon

YOR141C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARP8
locus tag: YOR141C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:23644470]
experiment: EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:17320816]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12887900]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:17320816]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:10952318|PMID:24034245]
note: Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity
codon start: 1
product: Arp8p
translation: MSQEEAESSIIYEEPIDIPLEDDDDEDELEEENSVPLSSQADQENAENESDDSVDNVVGSETPRSVTGLSVDPRDVADEEDEDEEGEDEDEDEDDNDVDNEDENDNDNANENENELGSSRDKRAPPAVQTSKRYKKYPKLDPAKAPPGKKVPLHLLEKRRLGRIKAAEEFAKTLKKIGIEKVETTTLPATGLFQPLMLINQKNYSSDYLKKDDQIFALRDRKFLRNNNTSQISSTNTPDVIDLKSLPHSEASAAPLNDEIDLNDPTATIVIHPGSNSIKIGFPKDDHPVVVPNCVAVPKKWLDLENSEHVENVCLQREQSEEFNNIKSEMEKNFRERMRYYKRKVPGNAHEQVVSFNENSKPEIISEKNDPSPIEWIFDDSKLYYGSDALRCVDEKFVIRKPFRGGSFNVKSPYYKSLAELISDVTKLLEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFLLQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQLYNFMNRSPNQPTEKYEFKLFDEVMLAPLALFFPQIFKLIRTSSHKNSSLEFQLPESRDLFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDKPENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTDRINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEELEEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVHGSRILQYKCIFTY
SIO_010081: YOR141C
subclass of: SO_0000673
so part of: YOR141C
location: complement(589942..592587)
location: region:589942-592587:-1
so has part: feature:589942-592587:-1:exon

NP_014784.1
type: Protein
SIO_000068: ncbiprotein

S000005667
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:589942-592587:-1:exon

YOR142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LSC1
locus tag: YOR142W
so part of: sequence
location: <593057..>594046
location: region:593057-594046:1
so has part: feature:593057-594046:1:exon
subclass of: SO_0000010

854310
type: Gene
SIO_000068: ncbigene

position:593057:1
position: 593057
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:594046:1
position: 594046
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593057-594046:1:exon

YOR142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LSC1
locus tag: YOR142W
product: succinate--CoA ligase (GDP-forming) subunit alpha
transcript id: NM_001183561.3
SIO_010081: YOR142W
subclass of: SO_0000673
so part of: YOR142W
location: <593057..>594046
location: region:593057-594046:1
so has part: feature:593057-594046:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593057-594046:1:exon

YOR142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LSC1
locus tag: YOR142W
EC number: 6.2.1.5
experiment: EXISTENCE:direct assay:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9874242|PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0006104 succinyl-CoA metabolic process [PMID:9874242]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]
experiment: EXISTENCE:mutant phenotype:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]
note: Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
codon start: 1
product: succinate--CoA ligase (GDP-forming) subunit alpha
translation: MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK
SIO_010081: YOR142W
subclass of: SO_0000673
so part of: YOR142W
location: 593057..594046
location: region:593057-594046:1
so has part: feature:593057-594046:1:exon

NP_014785.3
type: Protein
SIO_000068: ncbiprotein

S000005668
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593057-594046:1:exon

YNCO0020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF5
locus tag: YNCO0020C
so part of: sequence
location: complement(594354..594425)
location: region:594354-594425:-1
so has part: feature:594354-594425:-1:exon
subclass of: SO_0000663

854311
type: Gene
SIO_000068: ncbigene

position:594354:-1
position: 594354
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:594425:-1
position: 594425
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594354-594425:-1:exon

YNCO0020C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF5
locus tag: YNCO0020C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons
SIO_010081: YNCO0020C
subclass of: SO_0000673
so part of: YNCO0020C
location: complement(594354..594425)
location: region:594354-594425:-1
so has part: feature:594354-594425:-1:exon

S000006573
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:594354-594425:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 594512..594819
location: region:594512-594819:1
so has part: feature:594512-594819:1:region

S000007169
type: SGD
SIO_000068: sgd

position:594512:1
position: 594512
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:594819:1
position: 594819
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594512-594819:1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YORWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YORWTy1-2
so part of: sequence
location: 594820..600733
location: region:594820-600733:1
so has part: feature:594820-600733:1:region

S000007182
type: SGD
SIO_000068: sgd

position:594820:1
position: 594820
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:600733:1
position: 600733
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594820-600733:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 594820..595151
location: region:594820-595151:1
so has part: feature:594820-595151:1:region

S000007170
type: SGD
SIO_000068: sgd

position:595151:1
position: 595151
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594820-595151:1:region

YOR142W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR142W-B
so part of: sequence
location: <595112..>600380
location: region:595112-600380:1
so has part: feature:595112-600380:1:exon
subclass of: SO_0000010

854313
type: Gene
SIO_000068: ncbigene

position:595112:1
position: 595112
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:600380:1
position: 600380
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:595112-600380:1:exon

YOR142W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR142W-B
product: gag-pol fusion protein
transcript id: NM_001184386.2
SIO_010081: YOR142W-B
subclass of: SO_0000673
so part of: YOR142W-B
location: <595112..>600380
location: region:595112-600380:1
so has part: feature:595112-600380:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:595112-600380:1:exon

YOR142W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR142W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNSNKRIIAKLKMQYDTKIINLGESDDEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPNGRKLGAPGQPGLYINQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YOR142W-B
subclass of: SO_0000673
so part of: YOR142W-B
location: join(595112..596416,596418..600380)
location: region:595112-600380:1
so has part: feature:595112-596416:1:exon
so has part: feature:596418-600380:1:exon

NP_058183.1
type: Protein
SIO_000068: ncbiprotein

S000007352
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:595112-596416:1:exon

position:596416:1
position: 596416
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:596418-600380:1:exon

position:596418:1
position: 596418
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YOR142W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR142W-A
so part of: sequence
location: <595112..>596434
location: region:595112-596434:1
so has part: feature:595112-596434:1:exon
subclass of: SO_0000010

854312
type: Gene
SIO_000068: ncbigene

position:596434:1
position: 596434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:595112-596434:1:exon

YOR142W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR142W-A
product: gag protein
transcript id: NM_001184385.3
SIO_010081: YOR142W-A
subclass of: SO_0000673
so part of: YOR142W-A
location: <595112..>596434
location: region:595112-596434:1
so has part: feature:595112-596434:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:595112-596434:1:exon

YOR142W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR142W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRPITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YOR142W-A
subclass of: SO_0000673
so part of: YOR142W-A
location: 595112..596434
location: region:595112-596434:1
so has part: feature:595112-596434:1:exon

NP_058184.3
type: Protein
SIO_000068: ncbiprotein

S000007351
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:595112-596434:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 600402..600733
location: region:600402-600733:1
so has part: feature:600402-600733:1:region

S000007171
type: SGD
SIO_000068: sgd

position:600402:1
position: 600402
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:600402-600733:1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1502; Autonomously Replicating Sequence
so part of: sequence
location: 600886..600960
location: region:600886-600960:1
so has part: feature:600886-600960:1:region

S000007643
type: SGD
SIO_000068: sgd

position:600886:1
position: 600886
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:600960:1
position: 600960
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:600886-600960:1:region

YOR143C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THI80
locus tag: YOR143C
so part of: sequence
location: complement(<601383..>602342)
location: region:601383-602342:-1
so has part: feature:601383-602342:-1:exon
subclass of: SO_0000010

854314
type: Gene
SIO_000068: ncbigene

position:601383:-1
position: 601383
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:602342:-1
position: 602342
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:601383-602342:-1:exon

YOR143C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THI80
locus tag: YOR143C
product: thiamine diphosphokinase
transcript id: NM_001183562.1
SIO_010081: YOR143C
subclass of: SO_0000673
so part of: YOR143C
location: complement(<601383..>602342)
location: region:601383-602342:-1
so has part: feature:601383-602342:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:601383-602342:-1:exon

YOR143C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THI80
locus tag: YOR143C
EC number: 2.7.6.2
experiment: EXISTENCE:direct assay:GO:0004788 thiamine diphosphokinase activity [PMID:18652651|PMID:8394343]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004788 thiamine diphosphokinase activity [PMID:8394343]
experiment: EXISTENCE:mutant phenotype:GO:0009229 thiamine diphosphate biosynthetic process [PMID:8394343]
note: Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
codon start: 1
product: thiamine diphosphokinase
translation: MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL
SIO_010081: YOR143C
subclass of: SO_0000673
so part of: YOR143C
location: complement(601383..602342)
location: region:601383-602342:-1
so has part: feature:601383-602342:-1:exon

NP_014786.1
type: Protein
SIO_000068: ncbiprotein

S000005669
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:601383-602342:-1:exon

YOR144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RTT110
gene: ELG1
locus tag: YOR144C
gene synonym: RTT110
so part of: sequence
location: complement(<602717..>605092)
location: region:602717-605092:-1
so has part: feature:602717-605092:-1:exon
subclass of: SO_0000010

854315
type: Gene
SIO_000068: ncbigene

position:602717:-1
position: 602717
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:605092:-1
position: 605092
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:602717-605092:-1:exon

YOR144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RTT110
gene: ELG1
locus tag: YOR144C
gene synonym: RTT110
product: Elg1p
transcript id: NM_001183563.3
SIO_010081: YOR144C
subclass of: SO_0000673
so part of: YOR144C
location: complement(<602717..>605092)
location: region:602717-605092:-1
so has part: feature:602717-605092:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:602717-605092:-1:exon

YOR144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RTT110
gene: ELG1
locus tag: YOR144C
gene synonym: RTT110
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18482875]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:19430531]
experiment: EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17170004]
experiment: EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12912927]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:19430531]
experiment: EXISTENCE:mutant phenotype:GO:0010526 negative regulation of transposition, RNA-mediated [PMID:11779788]
experiment: EXISTENCE:mutant phenotype:GO:0090618 DNA clamp unloading [PMID:29440488|PMID:23499004]
experiment: EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12909721]
note: Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
codon start: 1
product: Elg1p
translation: MKRHVSLSDILTGNKRKVRRQDALQITIDDENDTESGTFDARTAKHDDSSVIFLNHSVVKPIEAVSTNHKSAKEFLMTKRTKEKCDDDDDDLIVISDKSPKSETNCSKIALSQEHEDDISIISTSRIKSSLLNERASKIKNFLKHETTDTFKRLNSISKLNEIEPPLPLHQSIFPVGDKELSDRSVDIPLPFRTIPPLNHNFLPSDYESLKDKNSASCIPVRYQAPVLLGTNIKRNTTLTWPQLFKPVTLKQVLIEPKLKLRIKNWIETSFHTLEKPTLRNRLLNRINPNKQQGSGDELANFIVPDLEEDENLRPDFYRNGEANSSLSEFVPLMILHGNSIGKKTLIQTIMREIAGDDNSYQIYEVNSNMNRSKKDLLDILLDFTTTHYVKDSSKRKSDYGLVLFNDVDVLFKEHDRGYWAMISKLCEFSRRPLVLTCKDLSLVPSELIALASEQNSLFHTKKISTSTVYAFLTKYLKSLEIEVCDDWLRDVVKQNNADIRKCLMHLQFWCVDTEADLISSKNRLPVLTSTLGSSVKDISQLTDLLSINDVIGQATLNRSMVRQEIDSTTMTPEKVNTFQDQNLDDEMKLKFDYVIDYKLHLNDPNRQPLLPFELNIYQHIQEQLEARYSYVREANHRLDNEYLVNRFKKMTESTLNFLASRIPKYDHLQSARRTRNSKKISDILNQFKGIYNDETLNENAEIDLLSATTQQIKAEINPFVFEIAKSDANVKNENKQIFELHSENVSERRYKDLVYQLSQEGVLKNVWFNADPSIVVRKWEHLHSGFSKNK
SIO_010081: YOR144C
subclass of: SO_0000673
so part of: YOR144C
location: complement(602717..605092)
location: region:602717-605092:-1
so has part: feature:602717-605092:-1:exon

NP_014787.3
type: Protein
SIO_000068: ncbiprotein

S000005670
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:602717-605092:-1:exon

YOR145C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DIM2
alternative label: RRP20
gene: PNO1
locus tag: YOR145C
gene synonym: DIM2; RRP20
so part of: sequence
location: complement(<605347..>606171)
location: region:605347-606171:-1
so has part: feature:605347-606171:-1:exon
subclass of: SO_0000010

854317
type: Gene
SIO_000068: ncbigene

position:605347:-1
position: 605347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:606171:-1
position: 606171
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605347-606171:-1:exon

YOR145C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DIM2
alternative label: RRP20
gene: PNO1
locus tag: YOR145C
gene synonym: DIM2; RRP20
product: Pno1p
transcript id: NM_001183564.1
SIO_010081: YOR145C
subclass of: SO_0000673
so part of: YOR145C
location: complement(<605347..>606171)
location: region:605347-606171:-1
so has part: feature:605347-606171:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:605347-606171:-1:exon

YOR145C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DIM2
alternative label: RRP20
gene: PNO1
locus tag: YOR145C
gene synonym: DIM2; RRP20
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12502737]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10923024]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:18755838]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12502737]
experiment: EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:18755838]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12736301]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12736301]
experiment: EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:18755838]
experiment: EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12502737]
experiment: EXISTENCE:physical interaction:GO:0043248 proteasome assembly [PMID:12502737]
note: Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
codon start: 1
product: Pno1p
translation: MVAPTALKKATVTPVSGQDGGSSRIIGINNTESIDEDDDDDVLLDDSDNNTAKEEVEGEEGSRKTHESKTVVVDDQGKPRFTSASKTQGNKIKFESRKIMVPPHRMTPLRNSWTKIYPPLVEHLKLQVRMNLKTKSVELRTNPKFTTDPGALQKGADFIKAFTLGFDLDDSIALLRLDDLYIETFEVKDVKTLTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMARESVVSLILGSPPGKVYGNLRTVASRLKERY
SIO_010081: YOR145C
subclass of: SO_0000673
so part of: YOR145C
location: complement(605347..606171)
location: region:605347-606171:-1
so has part: feature:605347-606171:-1:exon

NP_014788.1
type: Protein
SIO_000068: ncbiprotein

S000005671
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605347-606171:-1:exon

YOR147W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDM32
locus tag: YOR147W
so part of: sequence
location: <606607..>608475
location: region:606607-608475:1
so has part: feature:606607-608475:1:exon
subclass of: SO_0000010

854318
type: Gene
SIO_000068: ncbigene

position:606607:1
position: 606607
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:608475:1
position: 608475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:606607-608475:1:exon

YOR147W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDM32
locus tag: YOR147W
product: Mdm32p
transcript id: NM_001183566.3
SIO_010081: YOR147W
subclass of: SO_0000673
so part of: YOR147W
location: <606607..>608475
location: region:606607-608475:1
so has part: feature:606607-608475:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:606607-608475:1:exon

YOR147W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDM32
locus tag: YOR147W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15631992]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:15631992]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:16020778]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266|PMID:16020778]
note: Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure
codon start: 1
product: Mdm32p
translation: MLITRLRVPTIKRPLLPITSHLVRHCIRTYVATNHGNVRPFITPYKSSLPVRCLIAQRHIRTFPSNDKFTTKASNIETILLRKNNEREFKQSLLADAKNFQERFKINLKWILIKNNRPFSLNEISIIASWLILSQILWLILSTTTFISFYLFVINSVFSQEYIHEKKIYERLLKWLLKDHKCSNQDLEITFSPEDKASMLVLSPDWESNSILIKRLNVRDEILDLDLKFHHINLNVSLKNWLLGRGLITNVSIYGIRGCLNLSNFINLVNSFQGDQKTENFLKTLNNVEITDSEILLKQSLSAQETPSLKFSIYNLSLPRLRLNHFISDILSAKTFSGSINNSLFNLFKRQQKLTAVIENNNKNRMASSKFDFTDNNQENYRTVTHQDDPNYVTTLRLNFININDLKFNGDGKFNWLKDGQVEILADIMLTNSTSHLSSESKYAVVDLKVTCRDLKTTFPQEPPVLSTGDSIVSLDELKPIITFINSYEGMANPILKDFSENERLTNSIIWNSPNVSINRQRKSYPLTTKVTSNSTKEIIKFHNQPNTNANEIVLRCKMVKNLSDLQLININQILDQITMELYVDLTKIVEDWEFKNKNDWMKQWGTTFASQLLLFGFGAMV
SIO_010081: YOR147W
subclass of: SO_0000673
so part of: YOR147W
location: 606607..608475
location: region:606607-608475:1
so has part: feature:606607-608475:1:exon

NP_014790.4
type: Protein
SIO_000068: ncbiprotein

S000005673
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:606607-608475:1:exon

YOR148C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPP2
locus tag: YOR148C
so part of: sequence
location: complement(<608640..>609197)
location: region:608640-609197:-1
so has part: feature:608640-609197:-1:exon
subclass of: SO_0000010

854319
type: Gene
SIO_000068: ncbigene

position:608640:-1
position: 608640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:609197:-1
position: 609197
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:608640-609197:-1:exon

YOR148C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPP2
locus tag: YOR148C
product: Spp2p
transcript id: NM_001183567.1
SIO_010081: YOR148C
subclass of: SO_0000673
so part of: YOR148C
location: complement(<608640..>609197)
location: region:608640-609197:-1
so has part: feature:608640-609197:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:608640-609197:-1:exon

YOR148C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPP2
locus tag: YOR148C
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:25561498]
experiment: EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:7493316]
experiment: EXISTENCE:direct assay:GO:0032781 positive regulation of ATP-dependent activity [PMID:25561498]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:7493316]
note: Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity
codon start: 1
product: Spp2p
translation: MSKFSLKLGSKTLKKNISKKTKKKNSLQKANLFDWDDAETASLSHKPQSKIKIQSIDKFDLDEESSSKKKLVIKLSENADTKKNDAPLVEYVTEKEYNEVPVEEFGDALLRGMGWESDSEQDSKGDKTQSRNKDVSNVSQIHPDGLGIGAKLNKAINVEEASFMPVVKIDKITGTKVDDDKKNKS
SIO_010081: YOR148C
subclass of: SO_0000673
so part of: YOR148C
location: complement(608640..609197)
location: region:608640-609197:-1
so has part: feature:608640-609197:-1:exon

NP_014791.1
type: Protein
SIO_000068: ncbiprotein

S000005674
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:608640-609197:-1:exon

YOR149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LAS2
alternative label: SAP2
gene: SMP3
locus tag: YOR149C
gene synonym: LAS2; SAP2
so part of: sequence
location: complement(<609838..>611388)
location: region:609838-611388:-1
so has part: feature:609838-611388:-1:exon
subclass of: SO_0000010

854320
type: Gene
SIO_000068: ncbigene

position:609838:-1
position: 609838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611388:-1
position: 611388
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:609838-611388:-1:exon

YOR149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LAS2
alternative label: SAP2
gene: SMP3
locus tag: YOR149C
gene synonym: LAS2; SAP2
product: glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
transcript id: NM_001183568.4
SIO_010081: YOR149C
subclass of: SO_0000673
so part of: YOR149C
location: complement(<609838..>611388)
location: region:609838-611388:-1
so has part: feature:609838-611388:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:609838-611388:-1:exon

YOR149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LAS2
alternative label: SAP2
gene: SMP3
locus tag: YOR149C
gene synonym: LAS2; SAP2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:11356840]
experiment: EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:2005867]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:11356840]
note: Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
codon start: 1
product: glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
translation: MMRYQWWLYLVYAIGLMLCLGPSYIHPDEHFQCIEILAMQFMKVKGTIPWEFKSKFAARSYGPLLLVYGPLFTILESFPEIQDNPALILYSMRLQNYVMYLLCYHFLIPKLIRDERKAVQFIKKSLLLTSYVTWTYQTHTFSNSIETLALISTLTVMEDMVNEKNIQRSNFKNSVILGLIFSFGVFNRVTFPAFIFLPCLILFWKFYRVHWKSFSLLLLSFSFSSCLFVLIDTNIYNNGKGFVITPLNNLKYNLNVQNLQVHGLHPRYTHLLVNLPQIVGPVLLLAIFSGYKLDKLSTYAIISGLLFLSFFQHQELRFLVPLVPLLVTNLNWTPLSSTLVNKKIFKGTWLLFNIIMAFIMGISHQAGIIQFLGDYFHFRTEQMGVHIWWKTYSPPTWMYMSNNLTVSSLINTQDGIESIDEVAFSVGNHHVIDLKGCDLPLLTETIRRLRLNGSITPLTLVTPNSMTSELKKLKRDGTINLIPKRNYLFHLDLDHLDFNDFTTFKPGLTVYSIELL
SIO_010081: YOR149C
subclass of: SO_0000673
so part of: YOR149C
location: complement(609838..611388)
location: region:609838-611388:-1
so has part: feature:609838-611388:-1:exon

NP_014792.4
type: Protein
SIO_000068: ncbiprotein

S000005675
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:609838-611388:-1:exon

YOR150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL13m
gene: MRPL23
locus tag: YOR150W
gene synonym: uL13m
so part of: sequence
location: <611999..>612490
location: region:611999-612490:1
so has part: feature:611999-612490:1:exon
subclass of: SO_0000010

854321
type: Gene
SIO_000068: ncbigene

position:611999:1
position: 611999
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:612490:1
position: 612490
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611999-612490:1:exon

YOR150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL13m
gene: MRPL23
locus tag: YOR150W
gene synonym: uL13m
product: mitochondrial 54S ribosomal protein YmL23
transcript id: NM_001183569.1
SIO_010081: YOR150W
subclass of: SO_0000673
so part of: YOR150W
location: <611999..>612490
location: region:611999-612490:1
so has part: feature:611999-612490:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611999-612490:1:exon

YOR150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL13m
gene: MRPL23
locus tag: YOR150W
gene synonym: uL13m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23509072]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]
note: Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2
codon start: 1
product: mitochondrial 54S ribosomal protein YmL23
translation: MSQKIGHSGLAFARLWHHVDVARDKRTLGRLASAIAITLIGRHKPVYHPSQDCGDYVVVTNCQKIRVTGKKFEQKTYWSHSGRPGQLKLQTMNKVVADKGFGEILKKAVSGMLPKNKLRKQRLDRLKVFDGSENPYKQNITAFAHEQSSIPEPLKESIFNQLK
SIO_010081: YOR150W
subclass of: SO_0000673
so part of: YOR150W
location: 611999..612490
location: region:611999-612490:1
so has part: feature:611999-612490:1:exon

NP_014793.1
type: Protein
SIO_000068: ncbiprotein

S000005676
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611999-612490:1:exon

YOR151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPB150
alternative label: RPO22
alternative label: SIT2
alternative label: SOH2
gene: RPB2
locus tag: YOR151C
gene synonym: RPB150; RPO22; SIT2; SOH2
so part of: sequence
location: complement(<612997..>616671)
location: region:612997-616671:-1
so has part: feature:612997-616671:-1:exon
subclass of: SO_0000010

854322
type: Gene
SIO_000068: ncbigene

position:612997:-1
position: 612997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:616671:-1
position: 616671
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:612997-616671:-1:exon

YOR151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPB150
alternative label: RPO22
alternative label: SIT2
alternative label: SOH2
gene: RPB2
locus tag: YOR151C
gene synonym: RPB150; RPO22; SIT2; SOH2
product: DNA-directed RNA polymerase II core subunit RPB2
transcript id: NM_001183570.3
SIO_010081: YOR151C
subclass of: SO_0000673
so part of: YOR151C
location: complement(<612997..>616671)
location: region:612997-616671:-1
so has part: feature:612997-616671:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:612997-616671:-1:exon

YOR151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPB150
alternative label: RPO22
alternative label: SIT2
alternative label: SOH2
gene: RPB2
locus tag: YOR151C
gene synonym: RPB150; RPO22; SIT2; SOH2
EC number: 2.7.7.6
experiment: EXISTENCE:direct assay:GO:0001055 RNA polymerase II activity [PMID:8288647]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:2406558]
note: RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit
codon start: 1
product: DNA-directed RNA polymerase II core subunit RPB2
translation: MSDLANSEKYYDEDPYGFEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNISRKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEAIDVPGRELKYELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEANEENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF
SIO_010081: YOR151C
subclass of: SO_0000673
so part of: YOR151C
location: complement(612997..616671)
location: region:612997-616671:-1
so has part: feature:612997-616671:-1:exon

NP_014794.3
type: Protein
SIO_000068: ncbiprotein

S000005677
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:612997-616671:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1518; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 616670..617517
location: region:616670-617517:1
so has part: feature:616670-617517:1:region

S000130136
type: SGD
SIO_000068: sgd

position:616670:1
position: 616670
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:617517:1
position: 617517
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616670-617517:1:region

YOR152C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATG40
locus tag: YOR152C
so part of: sequence
location: complement(<617518..>618288)
location: region:617518-618288:-1
so has part: feature:617518-618288:-1:exon
subclass of: SO_0000010

854323
type: Gene
SIO_000068: ncbigene

position:617518:-1
position: 617518
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:618288:-1
position: 618288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:617518-618288:-1:exon

YOR152C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATG40
locus tag: YOR152C
product: Atg40p
transcript id: NM_001183571.1
SIO_010081: YOR152C
subclass of: SO_0000673
so part of: YOR152C
location: complement(<617518..>618288)
location: region:617518-618288:-1
so has part: feature:617518-618288:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:617518-618288:-1:exon

YOR152C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATG40
locus tag: YOR152C
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26040717]
experiment: EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:26040717]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26040717]
note: Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy
codon start: 1
product: Atg40p
translation: MFNLILWPLFLLTSVAIPLQLTLEVVYLTSSVDFSKASAAKTATSLGQSPVVITIYKSLLKYWSLYEFIHFIYLYTPIDAFLNFLPFTSLLMSFGSICLTRELVYDFIAFMESQNKLTGFLNKITEPNFNSYLLFSSIYNIWFADDTNDKFLFGKLTQILISVTKRYEFPRTFYLAKVSDFLQNLILTRLRPFVTEQPQGDKNRYQNGDRESTKNGAAYQKSSQQSSSFEQNFTSTEFPNDYDFMEDILDETTELD
SIO_010081: YOR152C
subclass of: SO_0000673
so part of: YOR152C
location: complement(617518..618288)
location: region:617518-618288:-1
so has part: feature:617518-618288:-1:exon

NP_014795.1
type: Protein
SIO_000068: ncbiprotein

S000005678
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:617518-618288:-1:exon

YOR153W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LEM1
alternative label: STS1
alternative label: YDR1
gene: PDR5
locus tag: YOR153W
gene synonym: LEM1; STS1; YDR1
so part of: sequence
location: <619840..>624375
location: region:619840-624375:1
so has part: feature:619840-624375:1:exon
subclass of: SO_0000010

854324
type: Gene
SIO_000068: ncbigene

position:619840:1
position: 619840
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:624375:1
position: 624375
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:619840-624375:1:exon

YOR153W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LEM1
alternative label: STS1
alternative label: YDR1
gene: PDR5
locus tag: YOR153W
gene synonym: LEM1; STS1; YDR1
product: ATP-binding cassette multidrug transporter PDR5
transcript id: NM_001183572.3
SIO_010081: YOR153W
subclass of: SO_0000673
so part of: YOR153W
location: <619840..>624375
location: region:619840-624375:1
so has part: feature:619840-624375:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:619840-624375:1:exon

YOR153W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LEM1
alternative label: STS1
alternative label: YDR1
gene: PDR5
locus tag: YOR153W
gene synonym: LEM1; STS1; YDR1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:8810273]
experiment: EXISTENCE:direct assay:GO:0008559 ABC-type xenobiotic transporter activity [PMID:21207971]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030003 cellular cation homeostasis [PMID:8985171]
experiment: EXISTENCE:mutant phenotype:GO:0008559 ABC-type xenobiotic transporter activity [PMID:15707993]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:17881724]
experiment: EXISTENCE:mutant phenotype:GO:0030003 cellular cation homeostasis [PMID:8985171]
experiment: EXISTENCE:mutant phenotype:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:9450972]
note: Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication
codon start: 1
product: ATP-binding cassette multidrug transporter PDR5
translation: MPEAKLNNNVNDVTSYSSASSSTENAADLHNYNGFDEHTEARIQKLARTLTAQSMQNSTQSAPNKSDAQSIFSSGVEGVNPIFSDPEAPGYDPKLDPNSENFSSAAWVKNMAHLSAADPDFYKPYSLGCAWKNLSASGASADVAYQSTVVNIPYKILKSGLRKFQRSKETNTFQILKPMDGCLNPGELLVVLGRPGSGCTTLLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVVYNAEADVHLPHLTVFETLVTVARLKTPQNRIKGVDRESYANHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISNTSATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLTSVTSPSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVDQRLLNDDEASREAIKEAHIAKQSKRARPSSPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSMFFKIMKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSHLFRCVGSLTKTLSEAMVPASMLLLALSMYTGFAIPKKKILRWSKWIWYINPLAYLFESLLINEFHGIKFPCAEYVPRGPAYANISSTESVCTVVGAVPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMAYVVFFFFVYLFLCEYNEGAKQKGEILVFPRSIVKRMKKRGVLTEKNANDPENVGERSDLSSDRKMLQESSEEESDTYGEIGLSKSEAIFHWRNLCYEVQIKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPRDKSFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEVWRNSEEYRAVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIRLFQQYWRSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQNQMLAVFMFTVIFNPILQQYLPSFVQQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYFIYYYPIGFYSNASAAGQLHERGALFWLFSCAFYVYVGSMGLLVISFNQVAESAANLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQALLAVGVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAKTGYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLARVPKKNGKLSKK
SIO_010081: YOR153W
subclass of: SO_0000673
so part of: YOR153W
location: 619840..624375
location: region:619840-624375:1
so has part: feature:619840-624375:1:exon

NP_014796.3
type: Protein
SIO_000068: ncbiprotein

S000005679
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:619840-624375:1:exon

YOR154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLP1
locus tag: YOR154W
so part of: sequence
location: <624729..>626492
location: region:624729-626492:1
so has part: feature:624729-626492:1:exon
subclass of: SO_0000010

854325
type: Gene
SIO_000068: ncbigene

position:624729:1
position: 624729
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:626492:1
position: 626492
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:624729-626492:1:exon

YOR154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLP1
locus tag: YOR154W
product: Slp1p
transcript id: NM_001183573.1
SIO_010081: YOR154W
subclass of: SO_0000673
so part of: YOR154W
location: <624729..>626492
location: region:624729-626492:1
so has part: feature:624729-626492:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:624729-626492:1:exon

YOR154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLP1
locus tag: YOR154W
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:23275891]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]
note: Glycosylated integral ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
codon start: 1
product: Slp1p
translation: MANRLLIYGLILWVSIIGSFALDRNKTAQNAKIGLHDTTVITTGSTTNVQKEHSSPLSTGSLRTHDFRQASKVDIRQADIRENGERKEQDALTQPATPRNPGDSSNSFLSFDEWKKVKSKEHSSGPERHLSRVREPVDPSCYKEKECIGEELEIDLGFLTNKNEWSEREENQKGFNEEKDIEKVYKKKFNYASLDCAATIVKSNPEAIGATSTLIESKDKYLLNPCSAPQQFIVIELCEDILVEEIEIANYEFFSSTFKRFRVSVSDRIPMVKNEWTILGEFEARNSRELQKFQIHNPQIWASYLKIEILSHYEDEFYCPISLIKVYGKSMMDEFKIDQLKAQEDKEQSIGTNNINNLNEQNIQDRCNNIETRLETPNTSNLSDLAGALSCTSKLIPLKFDEFFKVLNASFCPSKQMISSSSSSAVPVIPEESIFKNIMKRLSQLETNSSLTVSYIEEQSKLLSKSFEQLEMAHEAKFSHLVTIFNETMMSNLDLLNNFANQLKDQSLRILEEQKLENDKFTNRHLLHLERLEKEVSFQRRIVYASFFAFVGLISYLLITRELYFEDFEESKNGAIEKADIVQQAIR
SIO_010081: YOR154W
subclass of: SO_0000673
so part of: YOR154W
location: 624729..626492
location: region:624729-626492:1
so has part: feature:624729-626492:1:exon

NP_014797.1
type: Protein
SIO_000068: ncbiprotein

S000005680
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:624729-626492:1:exon

YOR155C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ISN1
locus tag: YOR155C
so part of: sequence
location: complement(<626628..>627980)
location: region:626628-627980:-1
so has part: feature:626628-627980:-1:exon
subclass of: SO_0000010

854326
type: Gene
SIO_000068: ncbigene

position:626628:-1
position: 626628
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:627980:-1
position: 627980
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:626628-627980:-1:exon

YOR155C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ISN1
locus tag: YOR155C
product: IMP 5'-nucleotidase
transcript id: NM_001183574.3
SIO_010081: YOR155C
subclass of: SO_0000673
so part of: YOR155C
location: complement(<626628..>627980)
location: region:626628-627980:-1
so has part: feature:626628-627980:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:626628-627980:-1:exon

YOR155C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ISN1
locus tag: YOR155C
EC number: 3.1.3.99
experiment: EXISTENCE:direct assay:GO:0050483 IMP 5'-nucleotidase activity [PMID:12735798]
experiment: EXISTENCE:genetic interaction:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:genetic interaction:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:mutant phenotype:GO:0006190 inosine salvage [PMID:12735798]
experiment: EXISTENCE:mutant phenotype:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]
experiment: EXISTENCE:mutant phenotype:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]
note: Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms
codon start: 1
product: IMP 5'-nucleotidase
translation: MSSRYRVEYHLKSHRKDEFIDWVKGLLASPFVLHAVSHEGDYNDDLATTQRVRSQYADIFKDIEGLIKDKIEFDSRNMSQDEIEDGASSQSLNILGQSRLNLLVPSIGTFFTELPLEQAFLWEDSQRAISARRMVAPSFNDIRHILNTAQIFHFKKQENLHNGKVLRLVTFDGDVTLYEDGGSLVYTNPVIPYILKLLRCGINVGIVTAAGYDEAGTYENRLKGLIVALHDSTDIPVSQKQNLTIMGGESSYLFRYYEDPEEDNFGFRQIDKEEWLLPRMKAWSLEDVEKTLDFAERTLNRLRKRLNLPSEISIIRKVRAVGIVPGERYDEASKRQVPVKLDREQLEEIVLTLQNTLESFAPSRRIQFSCFDGGSDVWCDIGGKDLGVRSLQQFYNPESPIQPSETLHVGDQFAPVGSANDFKARLAGCTLWIASPQETVNYLHRLLETD
SIO_010081: YOR155C
subclass of: SO_0000673
so part of: YOR155C
location: complement(626628..627980)
location: region:626628-627980:-1
so has part: feature:626628-627980:-1:exon

NP_014798.3
type: Protein
SIO_000068: ncbiprotein

S000005681
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:626628-627980:-1:exon

YOR156C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SIZ2
gene: NFI1
locus tag: YOR156C
gene synonym: SIZ2
so part of: sequence
location: complement(<628360..>630540)
location: region:628360-630540:-1
so has part: feature:628360-630540:-1:exon
subclass of: SO_0000010

854327
type: Gene
SIO_000068: ncbigene

position:628360:-1
position: 628360
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:630540:-1
position: 630540
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628360-630540:-1:exon

YOR156C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SIZ2
gene: NFI1
locus tag: YOR156C
gene synonym: SIZ2
product: SUMO ligase NFI1
transcript id: NM_001183575.1
SIO_010081: YOR156C
subclass of: SO_0000673
so part of: YOR156C
location: complement(<628360..>630540)
location: region:628360-630540:-1
so has part: feature:628360-630540:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:628360-630540:-1:exon

YOR156C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SIZ2
gene: NFI1
locus tag: YOR156C
gene synonym: SIZ2
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16204216]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:23122649]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:12761287|PMID:23443663]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:12761287]
experiment: EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:26960795]
experiment: EXISTENCE:genetic interaction:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]
experiment: EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:23122649]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16204216]
experiment: EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:22345352|PMID:23122649]
experiment: EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:23122649]
note: SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance
codon start: 1
product: SUMO ligase NFI1
translation: MASVMSNNNNNNNNNNASYMFTNPLSNTGGGLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTGAFKHPVASGQLPVTALQSTALPPYSQQQALAYSFTSPFYKPIVQIPDANKKLKQSAGRGCTKMKFKVSKSNHDLLKSNKSYKLYLFSGFSIPFIYETVGHEAIDFPYPCELVFNGTKLEDNVKGLKKQNGTGNPANLTPYLKVPTEMNHLDLHYLNIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQNCNEDVEQVEISVDGSWKPIHNSSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKSFPTHVNPRNDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNYQDAFQMRSFLNQGATTNINDTPTNNSSINSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQRNPYGPNYNTTAQDRNLLGIEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSGHGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFNTSAQDNSEVVDLTSD
SIO_010081: YOR156C
subclass of: SO_0000673
so part of: YOR156C
location: complement(628360..630540)
location: region:628360-630540:-1
so has part: feature:628360-630540:-1:exon

NP_014799.1
type: Protein
SIO_000068: ncbiprotein

S000005682
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:628360-630540:-1:exon

YOR157C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUP1
locus tag: YOR157C
so part of: sequence
location: complement(<630966..>631751)
location: region:630966-631751:-1
so has part: feature:630966-631751:-1:exon
subclass of: SO_0000010

854328
type: Gene
SIO_000068: ncbigene

position:630966:-1
position: 630966
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:631751:-1
position: 631751
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:630966-631751:-1:exon

YOR157C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUP1
locus tag: YOR157C
product: proteasome core particle subunit beta 2
transcript id: NM_001183576.3
SIO_010081: YOR157C
subclass of: SO_0000673
so part of: YOR157C
location: complement(<630966..>631751)
location: region:630966-631751:-1
so has part: feature:630966-631751:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:630966-631751:-1:exon

YOR157C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUP1
locus tag: YOR157C
EC number: 3.4.25.1
experiment: EXISTENCE:curator inference:GO:0005789 endoplasmic reticulum membrane [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18504300|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
experiment: EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:9207060|PMID:9312134]
note: Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
codon start: 1
product: proteasome core particle subunit beta 2
translation: MAGLSFDNYQRNNFLAENSHTQPKATSTGTTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA
SIO_010081: YOR157C
subclass of: SO_0000673
so part of: YOR157C
location: complement(630966..631751)
location: region:630966-631751:-1
so has part: feature:630966-631751:-1:exon

NP_014800.3
type: Protein
SIO_000068: ncbiprotein

S000005683
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:630966-631751:-1:exon

YOR158W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mS26
gene: PET123
locus tag: YOR158W
gene synonym: mS26
so part of: sequence
location: <632164..>633120
location: region:632164-633120:1
so has part: feature:632164-633120:1:exon
subclass of: SO_0000010

854329
type: Gene
SIO_000068: ncbigene

position:632164:1
position: 632164
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:633120:1
position: 633120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:632164-633120:1:exon

YOR158W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mS26
gene: PET123
locus tag: YOR158W
gene synonym: mS26
product: mitochondrial 37S ribosomal protein PET123
transcript id: NM_001183577.1
SIO_010081: YOR158W
subclass of: SO_0000673
so part of: YOR158W
location: <632164..>633120
location: region:632164-633120:1
so has part: feature:632164-633120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:632164-633120:1:exon

YOR158W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mS26
gene: PET123
locus tag: YOR158W
gene synonym: mS26
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
codon start: 1
product: mitochondrial 37S ribosomal protein PET123
translation: MGKGAAKYGFKSGVFPTTRSILKSPTTKQTDIINKVKSPKPKGVLGIGYAKGVKHPKGSHRLSPKVNFIDVDNLIAKTVAEPQSIKSSNGSAQKVRLQKAELRRKFLIEAFRKEEARLLHKHEYLQKRTKELEKAKELELEKLNKEKSSDLTIMTLDKMMSQPLLRNRSPEESELLKLKRNYNRSLLNFQAHKKKLNELLNLYHVANEFIVTESQLLKKIDKVFNDETEEFTDAYDVTSNFTQFGNRKLLLSGNTTLQTQINNAIMGSLSNEKFFDISLVDSYLNKDLKNISNKIDSKLNPTSNGAGNNGNNNNTTNL
SIO_010081: YOR158W
subclass of: SO_0000673
so part of: YOR158W
location: 632164..633120
location: region:632164-633120:1
so has part: feature:632164-633120:1:exon

NP_014801.1
type: Protein
SIO_000068: ncbiprotein

S000005684
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:632164-633120:1:exon

YOR159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SME1
locus tag: YOR159C
so part of: sequence
location: complement(<633282..>633566)
location: region:633282-633566:-1
so has part: feature:633282-633566:-1:exon
subclass of: SO_0000010

854330
type: Gene
SIO_000068: ncbigene

position:633282:-1
position: 633282
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:633566:-1
position: 633566
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:633282-633566:-1:exon

YOR159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SME1
locus tag: YOR159C
product: mRNA splicing protein SME1
transcript id: NM_001183578.3
SIO_010081: YOR159C
subclass of: SO_0000673
so part of: YOR159C
location: complement(<633282..>633566)
location: region:633282-633566:-1
so has part: feature:633282-633566:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:633282-633566:-1:exon

YOR159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SME1
locus tag: YOR159C
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9012791|PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:8918241]
experiment: EXISTENCE:physical interaction:GO:1990935 splicing factor binding [PMID:9528767]
note: Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
codon start: 1
product: mRNA splicing protein SME1
translation: MSNKVKTKAMVPPINCIFNFLQQQTPVTIWLFEQIGIRIKGKIVGFDEFMNVVIDEAVEIPVNSADGKEDVEKGTPLGKILLKGDNITLITSAD
SIO_010081: YOR159C
subclass of: SO_0000673
so part of: YOR159C
location: complement(633282..633566)
location: region:633282-633566:-1
so has part: feature:633282-633566:-1:exon

NP_014802.3
type: Protein
SIO_000068: ncbiprotein

S000005685
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:633282-633566:-1:exon

YOR160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KAP111
gene: MTR10
locus tag: YOR160W
gene synonym: KAP111
so part of: sequence
location: <633839..>636757
location: region:633839-636757:1
so has part: feature:633839-636757:1:exon
subclass of: SO_0000010

854331
type: Gene
SIO_000068: ncbigene

position:633839:1
position: 633839
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:636757:1
position: 636757
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:633839-636757:1:exon

YOR160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KAP111
gene: MTR10
locus tag: YOR160W
gene synonym: KAP111
product: Mtr10p
transcript id: NM_001183579.1
SIO_010081: YOR160W
subclass of: SO_0000673
so part of: YOR160W
location: <633839..>636757
location: region:633839-636757:1
so has part: feature:633839-636757:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:633839-636757:1:exon

YOR160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KAP111
gene: MTR10
locus tag: YOR160W
gene synonym: KAP111
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9545233]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9412460|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:9545233|PMID:9412460]
experiment: EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:9545233]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0006403 RNA localization [PMID:12167699]
experiment: EXISTENCE:mutant phenotype:GO:0006404 RNA import into nucleus [PMID:16040803|PMID:17409072]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9412460|PMID:9545233]
experiment: EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:33074312]
experiment: EXISTENCE:mutant phenotype:GO:0051031 tRNA transport [PMID:17409072|PMID:20032305]
experiment: EXISTENCE:mutant phenotype:GO:0061015 snRNA import into nucleus [PMID:31189105]
note: Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
codon start: 1
product: Mtr10p
translation: MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNALLELNIFAAQTLRNKVTYDLSQLENNLPQFKDSLLTLLLSHNQKLIITQLNVALARLAIQFLEWQNPIFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIAEDVLKFLVSCIDLLQNTDGNSSSSISLEQILRCLNSWSYEFPVEQLLTVQPLINLVFETISNGNESDMEAFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLLPTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAWSVVISKNPDFFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVLPRYQESRKAYSDIFVKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAIENNNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNLPEQAKIRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHALMFFCSDCSKLLVGYIDQLINFFLNVQSSIDIESQFELCQGLSAVINNQPEAKVSVIFQKLVDDNLRQIEALIPQWKANPTLLAPQIADKIDLLYALFEELKPRYNYPQQGSEPLLPRIEFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFCEPILPSVAEFLIQGYLTTGFGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQLNDYHEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDIISWGFKTPPISTVSIEIVPDEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISCIVKCLRILTEANNNDATICIDWIYKVVEQLGQVTLNERDNLAKAVVEGLNSKDYRKVREGIRAFVGWYSRKNINSRFE
SIO_010081: YOR160W
subclass of: SO_0000673
so part of: YOR160W
location: 633839..636757
location: region:633839-636757:1
so has part: feature:633839-636757:1:exon

NP_014803.1
type: Protein
SIO_000068: ncbiprotein

S000005686
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:633839-636757:1:exon

YOR161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PNS1
locus tag: YOR161C
so part of: sequence
location: complement(<636939..>638558)
location: region:636939-638558:-1
so has part: feature:636939-638558:-1:exon
subclass of: SO_0000010

854332
type: Gene
SIO_000068: ncbigene

position:636939:-1
position: 636939
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:638558:-1
position: 638558
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:636939-638558:-1:exon

YOR161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PNS1
locus tag: YOR161C
product: Pns1p
transcript id: NM_001183580.3
SIO_010081: YOR161C
subclass of: SO_0000673
so part of: YOR161C
location: complement(<636939..>638558)
location: region:636939-638558:-1
so has part: feature:636939-638558:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:636939-638558:-1:exon

YOR161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PNS1
locus tag: YOR161C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
codon start: 1
product: Pns1p
translation: MPLNEKYERPPQPPPAYDPNHRPPSSSENSAAANVNDGQTPYHFRQDQYYNLNSKTSGAPIGSFDEAFPTENDNKPRWNDWPFTIFFLCTVGGFIAIAAITLRAWSQTYSSTGSGIYDGVNTGTLNTNAAILLVFVCIIALVFSVLGLTLCRIFPKQFIYCGMVINLVASLGTAIMYMSLRYWSAGIVFLVFTFMTAWCYWGMRSRIPLSVAVLKVVVDAMKKCPQIFFVSFVGALVASAFGFLFSAVIVATYIKYDPNSSNGGCDVSGGSCSHSKLIGVLVVVFFCGYYISEVIRNVIHCVISGVFGSWYYMSKSDQGMPRWPAFGALKRAMTYSFGSICFGSLLVALIDLLRQILQMIRHDVTSSGGGQIAIQILFMVFDWIIGFLKWLAEYFNHYAYSFIALYGKPYLRAAKETWYMLREKGMDALINDNLINIALGLFSMFASYMTALFTFLYLRFTSPQYNSNGAYNGALMAFSFVIALQICNIATEAIRSGTATFFVALGNDPEVFHHSYPHRFDEIFRAYPDVLRKLSHQNV
SIO_010081: YOR161C
subclass of: SO_0000673
so part of: YOR161C
location: complement(636939..638558)
location: region:636939-638558:-1
so has part: feature:636939-638558:-1:exon

NP_014804.3
type: Protein
SIO_000068: ncbiprotein

S000005687
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:636939-638558:-1:exon

YOR161C-C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YOR161C-C
so part of: sequence
location: complement(<639121..>639267)
location: region:639121-639267:-1
so has part: feature:639121-639267:-1:exon
subclass of: SO_0000010

1466484
type: Gene
SIO_000068: ncbigene

position:639121:-1
position: 639121
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:639267:-1
position: 639267
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:639121-639267:-1:exon

YOR161C-C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YOR161C-C
product: uncharacterized protein
transcript id: NM_001184625.1
SIO_010081: YOR161C-C
subclass of: SO_0000673
so part of: YOR161C-C
location: complement(<639121..>639267)
location: region:639121-639267:-1
so has part: feature:639121-639267:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:639121-639267:-1:exon

YOR161C-C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YOR161C-C
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MSYTRVDHPTGKMACHLRQILASPLFFANYVLHAAIHYPSSDIRGDIL
SIO_010081: YOR161C-C
subclass of: SO_0000673
so part of: YOR161C-C
location: complement(639121..639267)
location: region:639121-639267:-1
so has part: feature:639121-639267:-1:exon

NP_878172.1
type: Protein
SIO_000068: ncbiprotein

S000028712
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:639121-639267:-1:exon

YOR162C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PDR2
gene: YRR1
locus tag: YOR162C
gene synonym: PDR2
so part of: sequence
location: complement(<639560..>641992)
location: region:639560-641992:-1
so has part: feature:639560-641992:-1:exon
subclass of: SO_0000010

854333
type: Gene
SIO_000068: ncbigene

position:639560:-1
position: 639560
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:641992:-1
position: 641992
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:639560-641992:-1:exon

YOR162C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PDR2
gene: YRR1
locus tag: YOR162C
gene synonym: PDR2
product: Yrr1p
transcript id: NM_001183581.3
SIO_010081: YOR162C
subclass of: SO_0000673
so part of: YOR162C
location: complement(<639560..>641992)
location: region:639560-641992:-1
so has part: feature:639560-641992:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:639560-641992:-1:exon

YOR162C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PDR2
gene: YRR1
locus tag: YOR162C
gene synonym: PDR2
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10052137]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11909958]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:10052137|PMID:11134057]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11134057]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:10052137]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]
note: Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
codon start: 1
product: Yrr1p
translation: MKRRSDALLGSFQATNVTPPSDNSNSTAGGANGSNSGTPTSTSGKKRNKLIKSCGFCRRRKLRCDQQKPMCSTCISRNLTTCQYAEEFNKNIEKKATYGPYPNADLLKKVEELENKIRILEAEKNTNSSASSMYTSPNFPPLGTSVGRGSTETSSPLPDGVINPYADRYYLQSKHSGRSTLYGPTSMRTQIANSNWGFIEKYKQLWAKVKVERNKWKQNNQKTMCRELGLLDESDWQPDPLIKQICRFLPSYNKALSILDDFFNDGACNEINVILDKAKVRRDFLDYFMPEKEVKAEGDRSIVYILSNPKKNYYKAAVILLILCLKYFHTDVPTPIEKFFTLLKGASTAKVFYIERAQMLILFYYHRETYSFGGDGSDLVNINECLVTTVTTIGLHLNIRETFKEHEVFMGSIESLENVWLMAIFIDYNISCNVGRPLLINKFYLDENQDHCILNSKSKTYEGKLKRYLKLTRPMLLTLYDRDKFPDLKAYSKRIINFVEEELGPLGHYTGENISEEVPLRESRILSMAVGLLLSFYALIHSVLKVRNIESKNNTFQLVLINFSIIVNTTIRCYRIDKALYPEKFEASNPHLPPHMALSMSLTAGLFSKTLVFFCSLIYFKLTLFENGLCLSNDMEVGWSDLTKLTVPLDKDLSLGTAMSLYSSIFDRLFTVGNKELIRTMHRSSQFVIELAIERTYRTILGNVIEFRKLTEETWLAQIKQELDPQSDNPSSEAKIVSDRQRDLSLAVPTPTPSIIPMLPSPGETKNHAKSQSEIIQMLTDEFWANYNSGWEELINQSEFSTLFDDYKDN
SIO_010081: YOR162C
subclass of: SO_0000673
so part of: YOR162C
location: complement(639560..641992)
location: region:639560-641992:-1
so has part: feature:639560-641992:-1:exon

NP_014805.3
type: Protein
SIO_000068: ncbiprotein

S000005688
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:639560-641992:-1:exon

YOR163W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DDP1
locus tag: YOR163W
so part of: sequence
location: <642741..>643307
location: region:642741-643307:1
so has part: feature:642741-643307:1:exon
subclass of: SO_0000010

854334
type: Gene
SIO_000068: ncbigene

position:642741:1
position: 642741
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:643307:1
position: 643307
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:642741-643307:1:exon

YOR163W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DDP1
locus tag: YOR163W
product: polyphosphatase DDP1
transcript id: NM_001183582.1
SIO_010081: YOR163W
subclass of: SO_0000673
so part of: YOR163W
location: <642741..>643307
location: region:642741-643307:1
so has part: feature:642741-643307:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:642741-643307:1:exon

YOR163W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DDP1
locus tag: YOR163W
EC number: 3.6.1.52
EC number: 3.6.1.60
experiment: EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:21775424|PMID:31175919]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:21775424]
experiment: EXISTENCE:direct assay:GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity [PMID:10419486]
experiment: EXISTENCE:direct assay:GO:0015961 diadenosine polyphosphate catabolic process [PMID:10085096|PMID:9450008]
experiment: EXISTENCE:direct assay:GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity [PMID:10085096|PMID:9450008]
experiment: EXISTENCE:direct assay:GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity [PMID:10085096|PMID:9450008]
experiment: EXISTENCE:direct assay:GO:0050072 m7G(5')pppN diphosphatase activity [PMID:23353937]
experiment: EXISTENCE:direct assay:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:23353937]
note: Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
codon start: 1
product: polyphosphatase DDP1
translation: MGKTADNHGPVRSETAREGRENQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKDEPNYETTAQRETWEEAGCIGKIVANLGTVEDMRPPKDWNKDIKQFENSRKDSEVAKHPPRTEFHFYELEIENLLDKFPECHKRHRKLYSYTEAKQNLIDAKRPELLEALNRSAIIKDDK
SIO_010081: YOR163W
subclass of: SO_0000673
so part of: YOR163W
location: 642741..643307
location: region:642741-643307:1
so has part: feature:642741-643307:1:exon

NP_014806.1
type: Protein
SIO_000068: ncbiprotein

S000005689
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:642741-643307:1:exon

YOR164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ENV8
gene: GET4
locus tag: YOR164C
gene synonym: ENV8
so part of: sequence
location: complement(<643394..>644332)
location: region:643394-644332:-1
so has part: feature:643394-644332:-1:exon
subclass of: SO_0000010

854335
type: Gene
SIO_000068: ncbigene

position:643394:-1
position: 643394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:644332:-1
position: 644332
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:643394-644332:-1:exon

YOR164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ENV8
gene: GET4
locus tag: YOR164C
gene synonym: ENV8
product: Get4p
transcript id: NM_001183583.3
SIO_010081: YOR164C
subclass of: SO_0000673
so part of: YOR164C
location: complement(<643394..>644332)
location: region:643394-644332:-1
so has part: feature:643394-644332:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:643394-644332:-1:exon

YOR164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ENV8
gene: GET4
locus tag: YOR164C
gene synonym: ENV8
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]
experiment: EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]
experiment: EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:19325107]
note: Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
codon start: 1
product: Get4p
translation: MVPAESNAVQAKLAKTLQRFENKIKAGDYYEAHQTLRTIANRYVRSKSYEHAIELISQGALSFLKAKQGGSGTDLIFYLLEVYDLAEVKVDDISVARLVRLIAELDPSEPNLKDVITGMNNWSIKFSEYKFGDPYLHNTIGSKLLEGDFVYEAERYFMLGTHDSMIKYVDLLWDWLCQVDDIEDSTVAEFFSRLVFNYLFISNISFAHESKDIFLERFIEKFHPKYEKIDKNGYEIVFFEDYSDLNFLQLLLITCQTKDKSYFLNLKNHYLDFSQAYKSELEFLGQEYFNIVAPKQTNFLQDMMSGFLGGSK
SIO_010081: YOR164C
subclass of: SO_0000673
so part of: YOR164C
location: complement(643394..644332)
location: region:643394-644332:-1
so has part: feature:643394-644332:-1:exon

NP_014807.3
type: Protein
SIO_000068: ncbiprotein

S000005690
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:643394-644332:-1:exon

YOR165W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEY1
locus tag: YOR165W
so part of: sequence
location: <644566..>646896
location: region:644566-646896:1
so has part: feature:644566-646896:1:exon
subclass of: SO_0000010

854336
type: Gene
SIO_000068: ncbigene

position:644566:1
position: 644566
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:646896:1
position: 646896
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:644566-646896:1:exon

YOR165W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEY1
locus tag: YOR165W
product: dynamin-like GTPase SEY1
transcript id: NM_001183584.1
SIO_010081: YOR165W
subclass of: SO_0000673
so part of: YOR165W
location: <644566..>646896
location: region:644566-646896:1
so has part: feature:644566-646896:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:644566-646896:1:exon

YOR165W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEY1
locus tag: YOR165W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19665976|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:19665976]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:22508509|PMID:19665976]
experiment: EXISTENCE:genetic interaction:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]
experiment: EXISTENCE:genetic interaction:GO:0061024 membrane organization [PMID:12427979]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:19665976]
experiment: EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]
note: Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
codon start: 1
product: dynamin-like GTPase SEY1
translation: MADRPAIQLIDEEKEFHQSALQYFQQCIGNRDVGLDYHVISVFGSQSSGKSTLLNVLFNTNFDTMDAQVKRQQTTKGIWLAHTKQVNTTIEIDNDRPDIFVLDVEGSDGSERGEDQDFERKAALFAIAVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKNDNDHKVLLLFVIRDHVGVTPLSSLSDSVTRELEKIWTELSKPAGCEGSSLYDYFDLKFVGLAHKLLQEDKFTQDVKKLGDSFVMKGTENYYFKPQYHHRLPLDGWTMYAENCWDQIERNKDLDLPTQQILVARFKTEEISNEALEEFISKYDESIAPLKGNLGSLTSQLVKLKEECLTKYDEQASRYARNVYMEKREALNTKLNSHISGTINEFLESLMEKLWDDLKLEVSSRDKATTSFVESVAAGKSKIEKEFNESMETFKKLGLLISNEEITCKFSDDIEERIKQLRDAELKAKIGRIKKNLVPELKDHVIHLLSHPSKKVWDDIMNDFESTIKDNISAYQVEKDKYDFKIGLSESENAKIYKNIRILAWRTLDTTVHDYLKIDTIVSILRDRFEDVFRYDAEGSPRLWKTEEEIDGAFRVAKEHALEVFEVLSLAVTSDNVEIIPDVPMAEEESGEDNEIYRDNEGVFHSRRFAHILTELQKENVLDQFRRQINITVLDSKRSIITTRTHIPPWIYVLLAVLGWNEFVAVIRNPLFVTLTLILGATFFVIHKFGLWGPVVNVVQSAVGETRTAIKDKLRQFVVEDHEVKESFEMKDFSKNEQKEK
SIO_010081: YOR165W
subclass of: SO_0000673
so part of: YOR165W
location: 644566..646896
location: region:644566-646896:1
so has part: feature:644566-646896:1:exon

NP_014808.1
type: Protein
SIO_000068: ncbiprotein

S000005691
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:644566-646896:1:exon

YOR166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SWT1
locus tag: YOR166C
so part of: sequence
location: complement(<647126..>648502)
location: region:647126-648502:-1
so has part: feature:647126-648502:-1:exon
subclass of: SO_0000010

854337
type: Gene
SIO_000068: ncbigene

position:647126:-1
position: 647126
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:648502:-1
position: 648502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:647126-648502:-1:exon

YOR166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SWT1
locus tag: YOR166C
product: mRNA-processing endoribonuclease
transcript id: NM_001183585.3
SIO_010081: YOR166C
subclass of: SO_0000673
so part of: YOR166C
location: complement(<647126..>648502)
location: region:647126-648502:-1
so has part: feature:647126-648502:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:647126-648502:-1:exon

YOR166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SWT1
locus tag: YOR166C
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:19127978]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17030511|PMID:19127978]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19127978]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17030511]
experiment: EXISTENCE:mutant phenotype:GO:0004521 endoribonuclease activity [PMID:19127978]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17030511]
experiment: EXISTENCE:mutant phenotype:GO:0071032 nuclear mRNA surveillance of mRNP export [PMID:19127978]
experiment: EXISTENCE:physical interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17030511]
note: RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
codon start: 1
product: mRNA-processing endoribonuclease
translation: MTDEKRAFPKGNNHIRSETFNGSVSHKISESIKDIASLRPHGKYTVQDIDNIIASTSSHENRGQSGDSNGCINHDEEGDIPMCDLNDESDVEMISEYLSSQREMEAQSVANYMPKINDDLPLLNPPTLKTAFVVDTNFIISHLNTLEKLRSLSSTYHHLIIVPTTVIQELDGLKKSPDIARDNDDTTNQEHDRTIGTLARWGNDWIYKNLANLDSGLIGQKLKQSLNPGSLKDDSILDCCLYFKEILNCFVILLSNDKNLCTKALTEDILTVSFRKNMDAKIIAMRAYEENQLRFANLRDSTVNNFDQNVTSYAHIPGIETPPLQFDKVSQNVFEQVKETIFFAIDHTLRKEYGEDIGFIDYNPDKLTTIENASNYIYLFWVSVFSELFTCSKIKKNEWKSLPTVLKSKPTNLNDLRTFEQFWETVLHFLFSKFTNEEKQSLEKQIHEWKTSINAIST
SIO_010081: YOR166C
subclass of: SO_0000673
so part of: YOR166C
location: complement(647126..648502)
location: region:647126-648502:-1
so has part: feature:647126-648502:-1:exon

NP_014809.3
type: Protein
SIO_000068: ncbiprotein

S000005692
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:647126-648502:-1:exon

YOR167C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS33A
gene: RPS28A
locus tag: YOR167C
gene synonym: RPS33A
so part of: sequence
location: complement(<648804..>649007)
location: region:648804-649007:-1
so has part: feature:648804-649007:-1:exon
subclass of: SO_0000010

854338
type: Gene
SIO_000068: ncbigene

position:648804:-1
position: 648804
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:649007:-1
position: 649007
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:648804-649007:-1:exon

YOR167C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS33A
gene: RPS28A
locus tag: YOR167C
gene synonym: RPS33A
product: ribosomal 40S subunit protein S28A
transcript id: NM_001183586.1
SIO_010081: YOR167C
subclass of: SO_0000673
so part of: YOR167C
location: complement(<648804..>649007)
location: region:648804-649007:-1
so has part: feature:648804-649007:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:648804-649007:-1:exon

YOR167C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS33A
gene: RPS28A
locus tag: YOR167C
gene synonym: RPS33A
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:24492965]
note: Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S28A
translation: MDNKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR
SIO_010081: YOR167C
subclass of: SO_0000673
so part of: YOR167C
location: complement(648804..649007)
location: region:648804-649007:-1
so has part: feature:648804-649007:-1:exon

NP_014810.1
type: Protein
SIO_000068: ncbiprotein

S000005693
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:648804-649007:-1:exon

YOR168W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLN4
locus tag: YOR168W
so part of: sequence
location: <649303..>651732
location: region:649303-651732:1
so has part: feature:649303-651732:1:exon
subclass of: SO_0000010

854339
type: Gene
SIO_000068: ncbigene

position:649303:1
position: 649303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:651732:1
position: 651732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:649303-651732:1:exon

YOR168W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLN4
locus tag: YOR168W
product: glutamine--tRNA ligase
transcript id: NM_001183587.3
SIO_010081: YOR168W
subclass of: SO_0000673
so part of: YOR168W
location: <649303..>651732
location: region:649303-651732:1
so has part: feature:649303-651732:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:649303-651732:1:exon

YOR168W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLN4
locus tag: YOR168W
EC number: 6.1.1.18
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004819 glutamine-tRNA ligase activity [PMID:2991203]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
experiment: EXISTENCE:mutant phenotype:GO:0006425 glutaminyl-tRNA aminoacylation [PMID:2991203]
note: Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions
codon start: 1
product: glutamine--tRNA ligase
translation: MSSVEELTQLFSQVGFEDKKVKEIVKNKKVSDSLYKLIKETPSDYQWNKSTRALVHNLASFVKGTDLPKSELIVNGIINGDLKTSLQVDAAFKYVKANGEASTKMGMNENSGVGIEITEDQVRNYVMQYIQENKERILTERYKLVPGIFADVKNLKELKWADPRSFKPIIDQEVLKLLGPKDERDLIKKKTKNNEKKKTNSAKKSSDNSASSGPKRTMFNEGFLGDLHKVGENPQAYPELMKEHLEVTGGKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEYFESIKRMVSWLGFKPWKITYSSDYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDGTPGGERYACKHRDQSIEQNLQEFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGTKWRIYPTYDFTHCLVDSMENITHSLCTTEFYLSRESYEWLCDQVHVFRPAQREYGRLNITGTVLSKRKIAQLVDEKFVRGWDDPRLFTLEAIRRRGVPPGAILSFINTLGVTTSTTNIQVVRFESAVRKYLEDTTPRLMFVLDPVEVVVDNLSDDYEELATIPYRPGTPEFGERTVPFTNKFYIERSDFSENVDDKEFFRLTPNQPVGLIKVSHTVSFKSLEKDEAGKIIRIHVNYDNKVEEGSKPKKPKTYIQWVPISSKYNSPLRVTETRVYNQLFKSENPSSHPEGFLKDINPESEVVYKESVMEHNFGDVVKNSPWVVDSVKNSEFYVEEDKDSKEVCRFQAMRVGYFTLDKESTTSKVILNRIVSLKDATSK
SIO_010081: YOR168W
subclass of: SO_0000673
so part of: YOR168W
location: 649303..651732
location: region:649303-651732:1
so has part: feature:649303-651732:1:exon

NP_014811.3
type: Protein
SIO_000068: ncbiprotein

S000005694
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:649303-651732:1:exon

YOR171C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LCB4
locus tag: YOR171C
so part of: sequence
location: complement(<652010..>653884)
location: region:652010-653884:-1
so has part: feature:652010-653884:-1:exon
subclass of: SO_0000010

854342
type: Gene
SIO_000068: ncbigene

position:652010:-1
position: 652010
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:653884:-1
position: 653884
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:652010-653884:-1:exon

YOR171C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LCB4
locus tag: YOR171C
product: sphinganine kinase LCB4
transcript id: NM_001183590.1
SIO_010081: YOR171C
subclass of: SO_0000673
so part of: YOR171C
location: complement(<652010..>653884)
location: region:652010-653884:-1
so has part: feature:652010-653884:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:652010-653884:-1:exon

YOR171C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LCB4
locus tag: YOR171C
EC number: 2.7.1.91
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12493772|PMID:16141212]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12459470]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16141212]
experiment: EXISTENCE:direct assay:GO:0006665 sphingolipid metabolic process [PMID:9677363]
experiment: EXISTENCE:direct assay:GO:0017050 D-erythro-sphingosine kinase activity [PMID:9677363]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:17686782]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]
note: Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication
codon start: 1
product: sphinganine kinase LCB4
translation: MVVQKKLRAILTDEGVLIKSQSHHMFNKHGQLRSGDSLSLLSCLSCLDDGTLSSDGGSFDEDDSLELLPLNTTIPFNRILNAKYVNVGQKGFNNGKISSNPFQTENLSSSSENDDVENHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDVIPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFLTKARPILVESGCKIEIAYTKYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDRVDAFNKLAVTQLPCGSGNAMSISCHWTNNPSYAALCLVKSIETRIDLMCCSQPSYMNEWPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKYAAKSKKELKVHFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPRDWEKMDSELTDNLTIFYTGKMPYIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVLEPEVIHSKILAYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGRYIDTEFESM
SIO_010081: YOR171C
subclass of: SO_0000673
so part of: YOR171C
location: complement(652010..653884)
location: region:652010-653884:-1
so has part: feature:652010-653884:-1:exon

NP_014814.1
type: Protein
SIO_000068: ncbiprotein

S000005697
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:652010-653884:-1:exon

YOR172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YRM1
locus tag: YOR172W
so part of: sequence
location: <654210..>656570
location: region:654210-656570:1
so has part: feature:654210-656570:1:exon
subclass of: SO_0000010

854343
type: Gene
SIO_000068: ncbigene

position:654210:1
position: 654210
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:656570:1
position: 656570
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:654210-656570:1:exon

YOR172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YRM1
locus tag: YOR172W
product: Yrm1p
transcript id: NM_001183591.3
SIO_010081: YOR172W
subclass of: SO_0000673
so part of: YOR172W
location: <654210..>656570
location: region:654210-656570:1
so has part: feature:654210-656570:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:654210-656570:1:exon

YOR172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YRM1
locus tag: YOR172W
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14512416]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:14512416]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:14512416]
note: Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
codon start: 1
product: Yrm1p
translation: MSKRGSLQDRASPSEETVKKAQKRRKPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSGCLYTEKFTHKIETKELFGSTPNIELLKRIEDLEKRLDDKELTEKDVALSTSPFRNPYANFYYLQCKGSGRRIVYGPTSLRTHLSNDDNRFVNTYNQLWSKVKIERNRWKARHKWTMKPETQLLEGPPLEKTGSDILQQVCNVLPSFEQSSKIITDFFNTELETNEVSEVLDKTKIINDFTSSFLPSDELLPNGERRIEKLLPSTKKNYYKIGVILMILCIRHFYKNTPEEIEKFLIMLTGLSTAKVYFIERAQFLLLKYYHRELIWACGDDSHMISLVDLLCSTAIMLGLHLNIREIYKNQENIVGSMESLENLWVWIILSDFNVSLNIGRCLAINSSYFQVDECENGERLPKNTNNYSSTVFFDQSNSCMGKLKRFLRLARPMLDQIYDRSAFPDLAENCKKLRNFVETEFHPISYYTDSELISKVPLCEIKVLAQVLNLLLTFYSLRYLIYKEKSVVLENNILQTILVSFSLVINTTILCFNLDEKHFPEFFDHNCVHLPPFMALSLVYTNFLFPRASTGFCAFLYHKLTLFEKGYYLSSNIKDQEVTDWDLSTLNIPLDKAMNLLTAFKIHSDIFAKWSNDNNKQLRIIMARSYTFVINIALESIYRAVLEKVIKYRTEVENTWLQQLQDELNGSYSLTDNVNTPIDPSLSDLGVTSASPLAGNSPGLPPEEVRNNSENASHNNETGPIETELAQTISNEFWTAYNLGWEELMSQPDYKYLFDTQ
SIO_010081: YOR172W
subclass of: SO_0000673
so part of: YOR172W
location: 654210..656570
location: region:654210-656570:1
so has part: feature:654210-656570:1:exon

NP_014815.3
type: Protein
SIO_000068: ncbiprotein

S000005698
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:654210-656570:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1519; Autonomously Replicating Sequence
so part of: sequence
location: 656701..656772
location: region:656701-656772:1
so has part: feature:656701-656772:1:region

S000118490
type: SGD
SIO_000068: sgd

position:656701:1
position: 656701
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:656772:1
position: 656772
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:656701-656772:1:region

YOR173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DCS2
locus tag: YOR173W
so part of: sequence
location: <657264..>658325
location: region:657264-658325:1
so has part: feature:657264-658325:1:exon
subclass of: SO_0000010

854344
type: Gene
SIO_000068: ncbigene

position:657264:1
position: 657264
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:658325:1
position: 658325
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:657264-658325:1:exon

YOR173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DCS2
locus tag: YOR173W
product: 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
transcript id: NM_001183592.1
SIO_010081: YOR173W
subclass of: SO_0000673
so part of: YOR173W
location: <657264..>658325
location: region:657264-658325:1
so has part: feature:657264-658325:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:657264-658325:1:exon

YOR173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DCS2
locus tag: YOR173W
experiment: EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:16963086]
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:16963086]
experiment: EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:16963086]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:15240832]
note: m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication
codon start: 1
product: 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
translation: MGSQDLASLIGRFKYVRVLDSNPHTKVISLLGSIDGKDAVLTAEKTHFIFDETVRRPSQSGRSTPIFFHREIDEYSFLNGITDLKELTSNDIYYWGLSVLKQHILHNPTAKVNLIWPASQFHIKGYDQQDLHVVRETPDMYRNIVVPFIQEMCTSERMKWVNNILYEGAEDDRVVYKEYSSRNKEDGFVILPDMKWDGINIDSLYLVAIVYRDDIKSLRDLNPNHRDWLIRLNKKIKTIIPQHYDYNVNPDELRVFIHYQPSYYHFHVHIVNIRHPGVGEERGSGMTILLEDVIEALGFLGPEGYMKKTLTYVIGENHDLWKKGFKEEVEKQLKHDGIATSPEKGSGFNTNLG
SIO_010081: YOR173W
subclass of: SO_0000673
so part of: YOR173W
location: 657264..658325
location: region:657264-658325:1
so has part: feature:657264-658325:1:exon

NP_014816.2
type: Protein
SIO_000068: ncbiprotein

S000005699
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:657264-658325:1:exon

YOR174W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MED4
locus tag: YOR174W
so part of: sequence
location: <658747..>659601
location: region:658747-659601:1
so has part: feature:658747-659601:1:exon
subclass of: SO_0000010

854345
type: Gene
SIO_000068: ncbigene

position:658747:1
position: 658747
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:659601:1
position: 659601
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:658747-659601:1:exon

YOR174W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MED4
locus tag: YOR174W
product: Med4p
transcript id: NM_001183593.3
SIO_010081: YOR174W
subclass of: SO_0000673
so part of: YOR174W
location: <658747..>659601
location: region:658747-659601:1
so has part: feature:658747-659601:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:658747-659601:1:exon

YOR174W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MED4
locus tag: YOR174W
experiment: EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:9420330]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
codon start: 1
product: Med4p
translation: MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESVDRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFIWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKTDSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF
SIO_010081: YOR174W
subclass of: SO_0000673
so part of: YOR174W
location: 658747..659601
location: region:658747-659601:1
so has part: feature:658747-659601:1:exon

NP_014817.3
type: Protein
SIO_000068: ncbiprotein

S000005700
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:658747-659601:1:exon

YOR175C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LCA1
alternative label: LPT1
alternative label: SLC4
gene: ALE1
locus tag: YOR175C
gene synonym: LCA1; LPT1; SLC4
so part of: sequence
location: complement(<659815..>661674)
location: region:659815-661674:-1
so has part: feature:659815-661674:-1:exon
subclass of: SO_0000010

854346
type: Gene
SIO_000068: ncbigene

position:659815:-1
position: 659815
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:661674:-1
position: 661674
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:659815-661674:-1:exon

YOR175C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LCA1
alternative label: LPT1
alternative label: SLC4
gene: ALE1
locus tag: YOR175C
gene synonym: LCA1; LPT1; SLC4
product: lysophospholipid acyltransferase
transcript id: NM_001183594.1
SIO_010081: YOR175C
subclass of: SO_0000673
so part of: YOR175C
location: complement(<659815..>661674)
location: region:659815-661674:-1
so has part: feature:659815-661674:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:659815-661674:-1:exon

YOR175C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LCA1
alternative label: LPT1
alternative label: SLC4
gene: ALE1
locus tag: YOR175C
gene synonym: LCA1; LPT1; SLC4
EC number: 2.3.1.23
EC number: 2.3.1.51
EC number: 2.3.1.n6
EC number: 2.3.1.n7
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17890783|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008374 O-acyltransferase activity [PMID:17890783]
experiment: EXISTENCE:genetic interaction:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:17675291]
experiment: EXISTENCE:genetic interaction:GO:0046474 glycerophospholipid biosynthetic process [PMID:17675291]
experiment: EXISTENCE:genetic interaction:GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine [PMID:30514764]
experiment: EXISTENCE:mutant phenotype:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:17675291|PMID:17726007]
experiment: EXISTENCE:mutant phenotype:GO:0008374 O-acyltransferase activity [PMID:17890783]
experiment: EXISTENCE:mutant phenotype:GO:0046474 glycerophospholipid biosynthetic process [PMID:17890783|PMID:17675291|PMID:17726007]
experiment: EXISTENCE:mutant phenotype:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:17726007|PMID:17951629]
note: Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
codon start: 1
product: lysophospholipid acyltransferase
translation: MYNPVDAVLTKIITNYGIDSFTLRYAICLLGSFPLNAILKRIPEKRIGLKCCFIISMSMFYLFGVLNLVSGFRTLFISTMFTYLISRFYRSKFMPHLNFMFVMGHLAINHIHAQFLNEQTQTTVDITSSQMVLAMKLTSFAWSYYDGSCTSESDFKDLTEHQKSRAVRGHPPLLKFLAYAFFYSTLLTGPSFDYADFDSWLNCEMFRDLPESKKPMRRHHPGERRQIPKNGKLALWKVVQGLAWMILSTLGMKHFPVKYVLDKDGFPTRSFIFRIHYLFLLGFIHRFKYYAAWTISEGSCILCGLGYNGYDSKTQKIRWDRVRNIDIWTVETAQNTREMLEAWNMNTNKWLKYSVYLRVTKKGKKPGFRSTLFTFLTSAFWHGTRPGYYLTFATGALYQTCGKIYRRNFRPIFLREDGVTPLPSKKIYDLVGIYAIKLAFGYMVQPFIILDLKPSLMVWGSVYFYVHIIVAFSFFLFRGPYAKQVTEFFKSKQPKEIFIRKQKKLEKDISASSPNLGGILKAKIEHEKGKTAEEEEMNLGIPPIELEKWDNAKEDWEDFCKDYKEWRNKNGLEIEEENLSKAFERFKQEFSNAASGSGERVRKMSFSGYSPKPISKKEE
SIO_010081: YOR175C
subclass of: SO_0000673
so part of: YOR175C
location: complement(659815..661674)
location: region:659815-661674:-1
so has part: feature:659815-661674:-1:exon

NP_014818.1
type: Protein
SIO_000068: ncbiprotein

S000005701
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:659815-661674:-1:exon

YOR176W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HEM15
locus tag: YOR176W
so part of: sequence
location: <662401..>663582
location: region:662401-663582:1
so has part: feature:662401-663582:1:exon
subclass of: SO_0000010

854347
type: Gene
SIO_000068: ncbigene

position:662401:1
position: 662401
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:663582:1
position: 663582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:662401-663582:1:exon

YOR176W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HEM15
locus tag: YOR176W
product: ferrochelatase HEM15
transcript id: NM_001183595.3
SIO_010081: YOR176W
subclass of: SO_0000673
so part of: YOR176W
location: <662401..>663582
location: region:662401-663582:1
so has part: feature:662401-663582:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:662401-663582:1:exon

YOR176W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HEM15
locus tag: YOR176W
EC number: 4.98.1.1
experiment: EXISTENCE:direct assay:GO:0004325 ferrochelatase activity [PMID:1304908]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7629135]
experiment: EXISTENCE:mutant phenotype:GO:0004325 ferrochelatase activity [PMID:2185242]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]
note: Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
codon start: 1
product: ferrochelatase HEM15
translation: MLSRTIRTQGSFLRRSQLTITRSFSVTFNMQNAQKRSPTGIVLMNMGGPSKVEETYDFLYQLFADNDLIPISAKYQKTIAKYIAKFRTPKIEKQYREIGGGSPIRKWSEYQATEVCKILDKTCPETAPHKPYVAFRYAKPLTAETYKQMLKDGVKKAVAFSQYPHFSYSTTGSSINELWRQIKALDSERSISWSVIDRWPTNEGLIKAFSENITKKLQEFPQPVRDKVVLLFSAHSLPMDVVNTGDAYPAEVAATVYNIMQKLKFKNPYRLVWQSQVGPKPWLGAQTAEIAEFLGPKVDGLMFIPIAFTSDHIETLHEIDLGVIGESEYKDKFKRCESLNGNQTFIEGMADLVKSHLQSNQLYSNQLPLDFALGKSNDPVKDLSLVFGNHEST
SIO_010081: YOR176W
subclass of: SO_0000673
so part of: YOR176W
location: 662401..663582
location: region:662401-663582:1
so has part: feature:662401-663582:1:exon

NP_014819.3
type: Protein
SIO_000068: ncbiprotein

S000005702
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:662401-663582:1:exon

YNCO0021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCO0021C
so part of: sequence
location: complement(663812..663885)
location: region:663812-663885:-1
so has part: feature:663812-663885:-1:exon
subclass of: SO_0000663

854348
type: Gene
SIO_000068: ncbigene

position:663812:-1
position: 663812
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:663885:-1
position: 663885
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:663812-663885:-1:exon

YNCO0021C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCO0021C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCO0021C
subclass of: SO_0000673
so part of: YNCO0021C
location: complement(663812..663885)
location: region:663812-663885:-1
so has part: feature:663812-663885:-1:exon

S000006766
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:663812-663885:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(664003..664324)
location: region:664003-664324:-1
so has part: feature:664003-664324:-1:region

S000007163
type: SGD
SIO_000068: sgd

position:664003:-1
position: 664003
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:664324:-1
position: 664324
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:664003-664324:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 664325..664469
location: region:664325-664469:1
so has part: feature:664325-664469:1:region

S000007172
type: SGD
SIO_000068: sgd

position:664325:1
position: 664325
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:664469:1
position: 664469
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:664325-664469:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 664813..665145
location: region:664813-665145:1
so has part: feature:664813-665145:1:region

S000007173
type: SGD
SIO_000068: sgd

position:664813:1
position: 664813
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:665145:1
position: 665145
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:664813-665145:1:region