Saccharomyces cerevisiae S288C chromosome XIV, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome XIV, complete sequence.
sequence version: NC_001146.8
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001146.8
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169873
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006947.\n\nOn Apr 26, 2011 this sequence version replaced NC_001146.7.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 784333
topology: linear
so has quality: SO_0000987
location: 1..784333
location: region:1-784333:1
RO_0002162: 559292

NC_001146
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications
author: Philippsen, P.
author: Kleine, K.
author: Pohlmann, R.
author: Dusterhoft, A.
author: Hamberg, K.
author: Hegemann, J.H.
author: Obermaier, B.
author: Urrestarazu, L.A.
author: Aert, R.
author: Albermann, K.
author: Altmann, R.
author: Andre, B.
author: Baladron, V.
author: Ballesta, J.P.
author: Becam, A.M.
author: Beinhauer, J.
author: Boskovic, J.
author: Buitrago, M.J.
author: Bussereau, F.
author: Coster, F.
author: Crouzet, M.
author: D'Angelo, M.
author: Dal Pero, F.
author: De Antoni, A.
author: Hani, J. et al.
journal: Nature 387 (6632 SUPPL), 93-98 (1997)
pubmed: 9169873

9169873
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

7
title: Direct Submission
journal: Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

8
title: Direct Submission
journal: Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:784333:1
position: 784333
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-784333:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: XIV

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL14L; Telomeric region on the left arm of Chromosome XIV; composed of an X element core sequence, X element combinatorial repeats, a short stretch of telomeric repeats, and a long Y' element
so part of: sequence
location: complement(1..7428)
location: region:1-7428:-1
so has part: feature:1-7428:-1:region

S000028924
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:7428:-1
position: 7428
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-7428:-1:region

YNL339C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-6
locus tag: YNL339C
gene synonym: YRF1
so part of: sequence
location: complement(<371..>6098)
location: region:371-6098:-1
so has part: feature:371-6098:-1:exon
subclass of: SO_0000010

855377
type: Gene
SIO_000068: ncbigene

position:371:-1
position: 371
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:6098:-1
position: 6098
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371-6098:-1:exon

YNL339C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-6
locus tag: YNL339C
gene synonym: YRF1
product: Y' element ATP-dependent helicase protein 1 copy 6
transcript id: NM_001183177.1
SIO_010081: YNL339C
subclass of: SO_0000673
so part of: YNL339C
location: complement(join(<371..5931,6080..>6098))
location: region:371-6098:-1
so has part: feature:6080-6098:-1:exon
so has part: feature:371-5931:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6080-6098:-1:exon

position:6080:-1
position: 6080
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:371-5931:-1:exon

position:5931:-1
position: 5931
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL339C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-6
locus tag: YNL339C
gene synonym: YRF1
EC number: 3.6.4.12
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]
note: Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
codon start: 1
product: Y' element ATP-dependent helicase protein 1 copy 6
translation: MEIENEQICTCIAQILHLLNSLIITFLDDDKTETGQSFVYIDGFLVKKHNNQHTIVNFETYKNKMKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCYEIASARPNDSSTMRTFTDFVSGTPIVRGLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
SIO_010081: YNL339C
subclass of: SO_0000673
so part of: YNL339C
location: complement(join(371..5931,6080..6098))
location: region:371-6098:-1
so has part: feature:6080-6098:-1:exon
so has part: feature:371-5931:-1:exon

NP_014060.1
type: Protein
SIO_000068: ncbiprotein

S000005283
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6080-6098:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:371-5931:-1:exon

YNL336W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS1
locus tag: YNL336W
so part of: sequence
location: <8330..>9475
location: region:8330-9475:1
so has part: feature:8330-9475:1:exon
subclass of: SO_0000010

855380
type: Gene
SIO_000068: ncbigene

position:8330:1
position: 8330
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:9475:1
position: 9475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:8330-9475:1:exon

YNL336W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS1
locus tag: YNL336W
product: Cos1p
transcript id: NM_001183174.1
SIO_010081: YNL336W
subclass of: SO_0000673
so part of: YNL336W
location: <8330..>9475
location: region:8330-9475:1
so has part: feature:8330-9475:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:8330-9475:1:exon

YNL336W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS1
locus tag: YNL336W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
codon start: 1
product: Cos1p
translation: MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEVTENTPSSDPHDWEVVAANLNSYLYENKAWNTKYFFFNAMVCQEAFRTTLLEPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNSEKSWSPVGLEDAKLPKEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTFYLGWILFMLVQGFQNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWKNEEFFFDGIDCEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA
SIO_010081: YNL336W
subclass of: SO_0000673
so part of: YNL336W
location: 8330..9475
location: region:8330-9475:1
so has part: feature:8330-9475:1:exon

NP_014063.1
type: Protein
SIO_000068: ncbiprotein

S000005280
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:8330-9475:1:exon

YNL335W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DDI3
gene: DDI2
locus tag: YNL335W
gene synonym: DDI3
so part of: sequence
location: <11452..>12129
location: region:11452-12129:1
so has part: feature:11452-12129:1:exon
subclass of: SO_0000010

855381
type: Gene
SIO_000068: ncbigene

position:11452:1
position: 11452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:12129:1
position: 12129
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11452-12129:1:exon

YNL335W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DDI3
gene: DDI2
locus tag: YNL335W
gene synonym: DDI3
product: cyanamide hydratase
transcript id: NM_001183173.1
SIO_010081: YNL335W
subclass of: SO_0000673
so part of: YNL335W
location: <11452..>12129
location: region:11452-12129:1
so has part: feature:11452-12129:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11452-12129:1:exon

YNL335W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DDI3
gene: DDI2
locus tag: YNL335W
gene synonym: DDI3
EC number: 4.2.1.69
experiment: EXISTENCE:direct assay:GO:0018820 cyanamide hydratase activity [PMID:25847245]
experiment: EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:25847245]
note: Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p
codon start: 1
product: cyanamide hydratase
translation: MSQYGFVRVPREVEKAIPVVNAPRPRAVVPPPNSETARLVREYAAKELTAPVLNHSLRVFQYSVAIIRDQFPAWDLDQEVLYVTCLLHDIATTDKNMRATKMSFEYYGGILSRELVFNATGGNQDYADAVTEAIIRHQDLTGTGYITTLGLILQIATTLDNVGSNTDLIHIDTVSAINEQFPRLHWLSCFATVVDTENSRKPWGHTSSLGDDFSKKVICNTFGYN
SIO_010081: YNL335W
subclass of: SO_0000673
so part of: YNL335W
location: 11452..12129
location: region:11452-12129:1
so has part: feature:11452-12129:1:exon

NP_014064.1
type: Protein
SIO_000068: ncbiprotein

S000005279
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11452-12129:1:exon

YNL334C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNO2
locus tag: YNL334C
so part of: sequence
location: complement(<12208..>12876)
location: region:12208-12876:-1
so has part: feature:12208-12876:-1:exon
subclass of: SO_0000010

855382
type: Gene
SIO_000068: ncbigene

position:12208:-1
position: 12208
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:12876:-1
position: 12876
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:12208-12876:-1:exon

YNL334C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNO2
locus tag: YNL334C
product: putative pyridoxal 5'-phosphate synthase
transcript id: NM_001183172.1
SIO_010081: YNL334C
subclass of: SO_0000673
so part of: YNL334C
location: complement(<12208..>12876)
location: region:12208-12876:-1
so has part: feature:12208-12876:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:12208-12876:-1:exon

YNL334C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNO2
locus tag: YNL334C
EC number: 3.5.1.2
EC number: 4.3.3.6
note: hypothetical protein; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
codon start: 1
product: putative pyridoxal 5'-phosphate synthase
translation: MTVVIGVLALQGAFIEHVRHVEKCIVENRDFYEKKLSVMTVKDKNQLAQCDALIIPGGESTAMSLIAERTGFYDDLYAFVHNPSKVTWGTCAGMIYISQQLSNEEKLVKTLNLLKVKVKRNAFGRQAQSSTRICDFSNFIPHCNDFPATFIRAPVIEEVLDPEHVQVLYKLDGKDNGGQELIVAAKQKNNILATSFHPELAENDIRFHDWFIREFVLKNYSK
SIO_010081: YNL334C
subclass of: SO_0000673
so part of: YNL334C
location: complement(12208..12876)
location: region:12208-12876:-1
so has part: feature:12208-12876:-1:exon

NP_014065.1
type: Protein
SIO_000068: ncbiprotein

S000005278
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:12208-12876:-1:exon

YNL333W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNZ2
locus tag: YNL333W
so part of: sequence
location: <13267..>14163
location: region:13267-14163:1
so has part: feature:13267-14163:1:exon
subclass of: SO_0000010

855383
type: Gene
SIO_000068: ncbigene

position:13267:1
position: 13267
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14163:1
position: 14163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:13267-14163:1:exon

YNL333W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNZ2
locus tag: YNL333W
product: pyridoxine biosynthesis protein SNZ2
transcript id: NM_001183171.1
SIO_010081: YNL333W
subclass of: SO_0000673
so part of: YNL333W
location: <13267..>14163
location: region:13267-14163:1
so has part: feature:13267-14163:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:13267-14163:1:exon

YNL333W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNZ2
locus tag: YNL333W
EC number: 4.3.3.6
experiment: EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]
experiment: EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:30498136]
experiment: EXISTENCE:genetic interaction:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]
note: Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3
codon start: 1
product: pyridoxine biosynthesis protein SNZ2
translation: MSEFKVKTGLAQMLKGGVIMDVVTPEQAIIAERAGACAVMALERIPADMRKSGQVCRMSDPRMIKEIMEAVSIPVMAKVRIGHFVEAQILEELQVDYIDESEVLTPADWTHHIEKHNFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHITKIKAEIQQYKENLKTESDFAAKATELRVPVDLLKTTLSEGKLPVVNFAAGGVATPADAALLMQLGCEGVFVGSGIFKSSDPEKLACAIVEATTHYDNPAKLLQISSDLGDLMGGISIQSINEAGGKNGARLSEIGW
SIO_010081: YNL333W
subclass of: SO_0000673
so part of: YNL333W
location: 13267..14163
location: region:13267-14163:1
so has part: feature:13267-14163:1:exon

NP_014066.1
type: Protein
SIO_000068: ncbiprotein

S000005277
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:13267-14163:1:exon

YNL332W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THI12
locus tag: YNL332W
so part of: sequence
location: <14832..>15854
location: region:14832-15854:1
so has part: feature:14832-15854:1:exon
subclass of: SO_0000010

855384
type: Gene
SIO_000068: ncbigene

position:14832:1
position: 14832
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:15854:1
position: 15854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14832-15854:1:exon

YNL332W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THI12
locus tag: YNL332W
product: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
transcript id: NM_001183170.1
SIO_010081: YNL332W
subclass of: SO_0000673
so part of: YNL332W
location: <14832..>15854
location: region:14832-15854:1
so has part: feature:14832-15854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14832-15854:1:exon

YNL332W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THI12
locus tag: YNL332W
experiment: EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]
note: Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP
codon start: 1
product: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
translation: MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTNPSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITEDFQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPRLNNDLSYKQYQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFKRLALPA
SIO_010081: YNL332W
subclass of: SO_0000673
so part of: YNL332W
location: 14832..15854
location: region:14832-15854:1
so has part: feature:14832-15854:1:exon

NP_014067.1
type: Protein
SIO_000068: ncbiprotein

S000005276
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14832-15854:1:exon

YNL331C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAD14
locus tag: YNL331C
so part of: sequence
location: complement(<16118..>17248)
location: region:16118-17248:-1
so has part: feature:16118-17248:-1:exon
subclass of: SO_0000010

855385
type: Gene
SIO_000068: ncbigene

position:16118:-1
position: 16118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17248:-1
position: 17248
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:16118-17248:-1:exon

YNL331C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAD14
locus tag: YNL331C
product: putative aryl-alcohol dehydrogenase
transcript id: NM_001183169.1
SIO_010081: YNL331C
subclass of: SO_0000673
so part of: YNL331C
location: complement(<16118..>17248)
location: region:16118-17248:-1
so has part: feature:16118-17248:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:16118-17248:-1:exon

YNL331C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAD14
locus tag: YNL331C
experiment: EXISTENCE:direct assay:GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity [PMID:29079624]
note: Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family
codon start: 1
product: putative aryl-alcohol dehydrogenase
translation: MTDLFKPLPEPPTELGRLRVLSKTAGIRVSPLILGGASIGDAWSGFMGSMNKEQAFELLDAFYEAGGNCIDTANSYQNEESEIWIGEWMASRKLRDQIVIATKFTGDYKKYEVGGGKSANYCGNHKRSLHVSVRDSLRKLQTDWIDILYIHWWDYMSSIEEVMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSHGKTPFSVYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERKKNGEGLRTFVGGPEQTELEVKISEALTKIAEEHGTESVTAIAIAYVRSKAKNVFPLIGGRKIEHLKQNIEALSIKLTPEQIEYLESIVPFDVGFPKSLIGDDPAVTKKLSPLTSMSARIAFDN
SIO_010081: YNL331C
subclass of: SO_0000673
so part of: YNL331C
location: complement(16118..17248)
location: region:16118-17248:-1
so has part: feature:16118-17248:-1:exon

NP_014068.1
type: Protein
SIO_000068: ncbiprotein

S000005275
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:16118-17248:-1:exon

YNL330C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MOF6
alternative label: REC3
alternative label: SDI2
alternative label: SDS6
gene: RPD3
locus tag: YNL330C
gene synonym: MOF6; REC3; SDI2; SDS6
so part of: sequence
location: complement(<18001..>19302)
location: region:18001-19302:-1
so has part: feature:18001-19302:-1:exon
subclass of: SO_0000010

855386
type: Gene
SIO_000068: ncbigene

position:18001:-1
position: 18001
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:19302:-1
position: 19302
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:18001-19302:-1:exon

YNL330C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MOF6
alternative label: REC3
alternative label: SDI2
alternative label: SDS6
gene: RPD3
locus tag: YNL330C
gene synonym: MOF6; REC3; SDI2; SDS6
product: histone deacetylase RPD3
transcript id: NM_001183168.1
SIO_010081: YNL330C
subclass of: SO_0000673
so part of: YNL330C
location: complement(<18001..>19302)
location: region:18001-19302:-1
so has part: feature:18001-19302:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:18001-19302:-1:exon

YNL330C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MOF6
alternative label: REC3
alternative label: SDI2
alternative label: SDS6
gene: RPD3
locus tag: YNL330C
gene synonym: MOF6; REC3; SDI2; SDS6
EC number: 3.5.1.98
experiment: EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:8962081]
experiment: EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:12110674]
experiment: EXISTENCE:direct assay:GO:0032221 Rpd3S/Clr6-CII complex [PMID:16286007|PMID:16286008]
experiment: EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16286008|PMID:16314178|PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9234741]
experiment: EXISTENCE:genetic interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:19823668]
experiment: EXISTENCE:genetic interaction:GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle [PMID:17908798]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:19948887]
experiment: EXISTENCE:genetic interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:15143171]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:17296735]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15141165|PMID:16314178|PMID:17121596|PMID:20398213|P MID:24358376|PMID:24881874]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:14737171]
experiment: EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9150136]
experiment: EXISTENCE:mutant phenotype:GO:0004407 histone deacetylase activity [PMID:12110674|PMID:8962081|PMID:9512514|PMID:9572144]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22539722]
experiment: EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:14609951|PMID:19270272]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:12453428|PMID:15143171|PMID:19417103]
experiment: EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:17203076]
experiment: EXISTENCE:mutant phenotype:GO:0044804 autophagy of nucleus [PMID:31553911]
experiment: EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:18515193]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15254041|PMID:17210643|PMID:17296735|PMID:17706600|P MID:20398213]
experiment: EXISTENCE:mutant phenotype:GO:0051038 negative regulation of transcription involved in meiotic cell cycle [PMID:17158929]
experiment: EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10388812|PMID:10512855|PMID:19372273]
experiment: EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10082585|PMID:10388812|PMID:10512855]
experiment: EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:31553911]
experiment: EXISTENCE:physical interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:19823668]
experiment: EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]
experiment: EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:14737171]
experiment: EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9150136]
note: Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway
codon start: 1
product: histone deacetylase RPD3
translation: MVYEATPFDPITVKPSDKRRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVNYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDKDLPYNEYYEYYGPDYKLSVRPSNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLNHTPRDAEDLGDVEEDSAEAKDTKGGSQYARDLHVEHDNEFY
SIO_010081: YNL330C
subclass of: SO_0000673
so part of: YNL330C
location: complement(18001..19302)
location: region:18001-19302:-1
so has part: feature:18001-19302:-1:exon

NP_014069.1
type: Protein
SIO_000068: ncbiprotein

S000005274
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:18001-19302:-1:exon

YNL329C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS8
gene: PEX6
locus tag: YNL329C
gene synonym: PAS8
so part of: sequence
location: complement(<19541..>22633)
location: region:19541-22633:-1
so has part: feature:19541-22633:-1:exon
subclass of: SO_0000010

855387
type: Gene
SIO_000068: ncbigene

position:19541:-1
position: 19541
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:22633:-1
position: 22633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:19541-22633:-1:exon

YNL329C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS8
gene: PEX6
locus tag: YNL329C
gene synonym: PAS8
product: AAA family ATPase peroxin 6
transcript id: NM_001183167.1
SIO_010081: YNL329C
subclass of: SO_0000673
so part of: YNL329C
location: complement(<19541..>22633)
location: region:19541-22633:-1
so has part: feature:19541-22633:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:19541-22633:-1:exon

YNL329C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS8
gene: PEX6
locus tag: YNL329C
gene synonym: PAS8
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:12808025]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12808025]
experiment: EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:29321502]
experiment: EXISTENCE:genetic interaction:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:12808025]
experiment: EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:15634331]
note: AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death
codon start: 1
product: AAA family ATPase peroxin 6
translation: MKASLTFSLSGIYAPCSISRDIYLEYGDKKAECLYGTIRLPQYGPGCTPGKIVHCVLDDSLPFCSIVVPSKLFGFMPTQPTMDFCYFEPILDNVVPVLDSVTFLINEQLYSKLMDLPQEMQQIQFLHYKYNINSMETVVHSRDILTSGLCQILNCSPFPQGLVDFTETQLILVNDTEQKLSALKYANEDEEYALPKIGTNSALSIDLESLPCTISRDLLRPAPHINDDNSIYAFTDAETLLRLDVTSGSFITVSNMGCVRLVKLFVLLLPNGFKKRTIYAPPKIIASFPDCSVVTISKSNIGHTDIPIANQVFISRVGGWLQSQKCFQNIILTTLKKFFSESKRILCQNDLIPIAFDSSMADLNIAEENDESDDEDELGQYYKNDSLVWFFVTSAELDCFSKDNSHFIIDPNRTKLITTNITNRRPLPLSRSNLQRYYGFAETFYYDLHIFPYVRQLVNILETSFNCSQRGITLNASVLLHSTTNNVGKATMVRFASKYLGIHLLEIDCLSLTSNSRQLDSTSKIIGYIRAKCENVLPYASPAVIFLAHLDSILLDVNANQDPEAIKLQKSINFEMSKLLDDFTFKFPGTTFVGSVNNIDNVPSSFRSHMRFEILVPVPSEAQRLRIFQWYLSSHELNRDVQQKVPVSYMDNISFSSLSSYSAGLTPLDIKSIVETARMTATARFYQESKKCGWLPQSILITQEDLSKATSKARNEFSVSIGAPQIPNVTWDDIGGIDFVKGEILDTIDMPLKHPELFTSGMKKRSGILFYGPPGTGKTLMAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQKAREAKPCVIFFDEIDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRFDKLLYLGIPDTDTKQLNILEALTRKFVLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRIARMVEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYEAVRANFEGA
SIO_010081: YNL329C
subclass of: SO_0000673
so part of: YNL329C
location: complement(19541..22633)
location: region:19541-22633:-1
so has part: feature:19541-22633:-1:exon

NP_014070.1
type: Protein
SIO_000068: ncbiprotein

S000005273
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:19541-22633:-1:exon

YNL328C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDJ2
locus tag: YNL328C
so part of: sequence
location: complement(<22834..>23274)
location: region:22834-23274:-1
so has part: feature:22834-23274:-1:exon
subclass of: SO_0000010

855388
type: Gene
SIO_000068: ncbigene

position:22834:-1
position: 22834
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:23274:-1
position: 23274
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22834-23274:-1:exon

YNL328C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDJ2
locus tag: YNL328C
product: Mdj2p
transcript id: NM_001183166.1
SIO_010081: YNL328C
subclass of: SO_0000673
so part of: YNL328C
location: complement(<22834..>23274)
location: region:22834-23274:-1
so has part: feature:22834-23274:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:22834-23274:-1:exon

YNL328C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDJ2
locus tag: YNL328C
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16027163]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9325105]
experiment: EXISTENCE:genetic interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]
experiment: EXISTENCE:physical interaction:GO:0001405 PAM complex, Tim23 associated import motor [PMID:16027163]
experiment: EXISTENCE:physical interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]
note: Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
codon start: 1
product: Mdj2p
translation: MVLPIIIGLGVTMVALSVKSGLNAWTVYKTLSPLTIAKLNNIRIENPTAGYRDALKFKSSLIDEELKNRLNQYQGGFAPRMTEPEALLILDISAREINHLDEKLLKKKHRKAMVRNHPDRGGSPYMAAKINEAKEVLERSVLLRKR
SIO_010081: YNL328C
subclass of: SO_0000673
so part of: YNL328C
location: complement(22834..23274)
location: region:22834-23274:-1
so has part: feature:22834-23274:-1:exon

NP_014071.1
type: Protein
SIO_000068: ncbiprotein

S000005272
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:22834-23274:-1:exon

YNL327W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EGT2
locus tag: YNL327W
so part of: sequence
location: <24048..>27173
location: region:24048-27173:1
so has part: feature:24048-27173:1:exon
subclass of: SO_0000010

855389
type: Gene
SIO_000068: ncbigene

position:24048:1
position: 24048
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27173:1
position: 27173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:24048-27173:1:exon

YNL327W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EGT2
locus tag: YNL327W
product: Egt2p
transcript id: NM_001183165.2
SIO_010081: YNL327W
subclass of: SO_0000673
so part of: YNL327W
location: <24048..>27173
location: region:24048-27173:1
so has part: feature:24048-27173:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:24048-27173:1:exon

YNL327W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EGT2
locus tag: YNL327W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0030428 cell septum [PMID:15452134]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:8668141]
note: Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
codon start: 1
product: Egt2p
translation: MNKLLLHLVRVISILGLANALTQTQPILKDIQITDSYTKTKECTDPDHWFIIEGQLSIPKGSQQNITFQVPDAFSSFPQEPFSIKHNSNSVATISRPDKSTNNFTISIPEKSSEDITTTFNFLAQLTSDAKSKVTEPKSIVYSFYSENTMFNDVIDYVAKNTSAITTDGGIYKTNNTAWFTVDLPMRTFRNPVYLTSQTSSSSDYVFDTSLTKFEVVTAVDSFNEPINAIPYTTVHDYSTEDEIRCLFNSTISGGLYFRVTYFTKKLSTSSISNTVELTYPDEGTSVRLLGKRDTSTTLASELYSESAANIDSTTSDDTTSSDAAITPTYSNSTLSSYTSQSSAIPEVAVTASLSSGILSSTVDGASTSADASMSAVSTVSSSSEQASSSSISLSAPSSSNSTFTTPSSSLSATETYSIISSASISVTQASYIDNSTTTAVTQSTSTIAVSSAEKLSSTLSYTSNVTISVSSATQHTTTPSYVSNSTTLSSSSVLESVISSPYLANTTVSGASSASQSTNPPYVSNSTTSSATQLATIAPFAINITGTSISSSITNTSSVSSTTSSLSSGPFVSNTTVASGSYILTTTTESAQLTEIGSLIPISTITTSTTTSGTDKTGSNKVASSTEIAQSIVNNSSLSVSTINTNAATAAANARNATFTHATHSGSLQPSYHSSSLLSSTIDTKVTTATTSTSRDGSSSLAFTTGLNQSVVTGTDKSDTYSVISSTESAQVTEYDSLLPISTLKPTVVTGTSRNSTFSMVSSTKLTEATATDKGDAYSVISSTQSAQVTEYGSMLPISTLETPTVIMSTDESGYFTLTTCTESGQATEYGSLIPISTLDGSVIYTFTGESVVVGYSTTVGAAQYAQHTSLVPVSTIKGSKTSLSTEESVVAGYSTTVGAAQYAQHTSLVPVSTIKGSKTSLSTEESVVAGYSTTVDSAQYAEHTNLVAIDTLKTSTFQKATATEVCVTCTALSSPHSATLDAGTTISLPTSSSTSLSTIITWYSSSTIKPPSISTYSGAAGQLTIRIGSLLLGLISFLL
SIO_010081: YNL327W
subclass of: SO_0000673
so part of: YNL327W
location: 24048..27173
location: region:24048-27173:1
so has part: feature:24048-27173:1:exon

NP_014072.2
type: Protein
SIO_000068: ncbiprotein

S000005271
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:24048-27173:1:exon

YNL326C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PFA3
locus tag: YNL326C
so part of: sequence
location: complement(<27337..>28347)
location: region:27337-28347:-1
so has part: feature:27337-28347:-1:exon
subclass of: SO_0000010

855390
type: Gene
SIO_000068: ncbigene

position:27337:-1
position: 27337
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:28347:-1
position: 28347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27337-28347:-1:exon

YNL326C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PFA3
locus tag: YNL326C
product: palmitoyltransferase PFA3
transcript id: NM_001183164.1
SIO_010081: YNL326C
subclass of: SO_0000673
so part of: YNL326C
location: complement(<27337..>28347)
location: region:27337-28347:-1
so has part: feature:27337-28347:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:27337-28347:-1:exon

YNL326C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PFA3
locus tag: YNL326C
EC number: 2.3.1.225
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16301533|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16186255]
experiment: EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:16186255]
experiment: EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:16186255]
experiment: EXISTENCE:mutant phenotype:GO:0000324 fungal-type vacuole [PMID:16301533]
experiment: EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:26224664]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:16186255|PMID:16301533]
note: Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
codon start: 1
product: palmitoyltransferase PFA3
translation: MNDRLSLTSLFPRCLTTCLYIWTAYITLTRIHQIPRWFLALTIVPTLAVALYTYYKVIARGPGSPLDFPDLLVHDLKAAENGLELPPEYMSKRCLTLKHDGRFRVCQVCHVWKPDRCHHCSSCDVCILKMDHHCPWFAECTGFRNQKFFIQFLMYTTLYAFLVLIYTCYELGTWFNSGSFNRELIDFHLLGVALLAVAVFISVLAFTCFSIYQVCKNQTTIEVHGMRRYRRDLEILNDSYGTNEHLENIFDLGSSMANWQDIMGTSWLEWILPIETFKYKKSKHTKDEKGLYFNVRPQVQDRLLSSRCLEDQLLRRVTPRPSLEADRASVEIIDAN
SIO_010081: YNL326C
subclass of: SO_0000673
so part of: YNL326C
location: complement(27337..28347)
location: region:27337-28347:-1
so has part: feature:27337-28347:-1:exon

NP_014073.1
type: Protein
SIO_000068: ncbiprotein

S000005270
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:27337-28347:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1405; Autonomously Replicating Sequence
so part of: sequence
location: 28469..28700
location: region:28469-28700:1
so has part: feature:28469-28700:1:region

S000118382
type: SGD
SIO_000068: sgd

position:28469:1
position: 28469
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:28700:1
position: 28700
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:28469-28700:1:region

YNL325C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FIG4
locus tag: YNL325C
so part of: sequence
location: complement(<28739..>31378)
location: region:28739-31378:-1
so has part: feature:28739-31378:-1:exon
subclass of: SO_0000010

855392
type: Gene
SIO_000068: ncbigene

position:28739:-1
position: 28739
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31378:-1
position: 31378
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:28739-31378:-1:exon

YNL325C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FIG4
locus tag: YNL325C
product: phosphatidylinositol-3,5-bisphosphate 5-phosphatase
transcript id: NM_001183163.1
SIO_010081: YNL325C
subclass of: SO_0000673
so part of: YNL325C
location: complement(<28739..>31378)
location: region:28739-31378:-1
so has part: feature:28739-31378:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:28739-31378:-1:exon

YNL325C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FIG4
locus tag: YNL325C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14528018]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:14528018]
experiment: EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:14528018]
experiment: EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]
experiment: EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:11950935]
experiment: EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]
note: Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder
codon start: 1
product: phosphatidylinositol-3,5-bisphosphate 5-phosphatase
translation: MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ
SIO_010081: YNL325C
subclass of: SO_0000673
so part of: YNL325C
location: complement(28739..31378)
location: region:28739-31378:-1
so has part: feature:28739-31378:-1:exon

NP_014074.1
type: Protein
SIO_000068: ncbiprotein

S000005269
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:28739-31378:-1:exon

YNL323W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BRE3
alternative label: ROS3
gene: LEM3
locus tag: YNL323W
gene synonym: BRE3; ROS3
so part of: sequence
location: <31944..>33188
location: region:31944-33188:1
so has part: feature:31944-33188:1:exon
subclass of: SO_0000010

855393
type: Gene
SIO_000068: ncbigene

position:31944:1
position: 31944
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:33188:1
position: 33188
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31944-33188:1:exon

YNL323W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BRE3
alternative label: ROS3
gene: LEM3
locus tag: YNL323W
gene synonym: BRE3; ROS3
product: Lem3p
transcript id: NM_001183161.1
SIO_010081: YNL323W
subclass of: SO_0000673
so part of: YNL323W
location: <31944..>33188
location: region:31944-33188:1
so has part: feature:31944-33188:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31944-33188:1:exon

YNL323W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BRE3
alternative label: ROS3
gene: LEM3
locus tag: YNL323W
gene synonym: BRE3; ROS3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12133835|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12133835]
experiment: EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]
experiment: EXISTENCE:mutant phenotype:GO:0007166 cell surface receptor signaling pathway [PMID:11063677]
experiment: EXISTENCE:mutant phenotype:GO:0015247 aminophospholipid flippase activity [PMID:12133835]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:12842877]
experiment: EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:12133835]
experiment: EXISTENCE:physical interaction:GO:1990531 phospholipid-translocating ATPase complex [PMID:15090616]
note: Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p
codon start: 1
product: Lem3p
translation: MVNFDLGQVGEVFRRKDKGAIVSGDNPEEEEDVDASEFEEDEVKPVRTKNRRPKEDAFTQQRLAAINPVLTPRTVLPLYLLIAVVFVIVGGCILAQNSKVDEVTIYYQDCMTNATSSWSDIPSEHWQFVFHKYKTYNTAPQWRFVDDESDDFTKQRGTCQIRFTTPSDMKNNVYLNYVLEKFAANHRRYVLSFSEDQIRGEDASYETVHDATGINCKPLSKNADGKIYYPCGLIANSMFNDTFPLQLTNVGDTSNNYSLTNKGINWESDKKRYKKTKYNYTQIAPPPYWEKMYPDGYNETNIPDIQDWEEFQNWMRPGAFDKITKLIRINKNDTLPAGEYQLDIGLHWPVLEFNGKKGIYLTHGSHLGGRNPFLGIVYLIGGCICAAMALILLTFWLFGGRKIADASSLSWNMK
SIO_010081: YNL323W
subclass of: SO_0000673
so part of: YNL323W
location: 31944..33188
location: region:31944-33188:1
so has part: feature:31944-33188:1:exon

NP_014076.1
type: Protein
SIO_000068: ncbiprotein

S000005267
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31944-33188:1:exon

YNL322C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KRE1
locus tag: YNL322C
so part of: sequence
location: complement(<33294..>34235)
location: region:33294-34235:-1
so has part: feature:33294-34235:-1:exon
subclass of: SO_0000010

855394
type: Gene
SIO_000068: ncbigene

position:33294:-1
position: 33294
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:34235:-1
position: 34235
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:33294-34235:-1:exon

YNL322C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KRE1
locus tag: YNL322C
product: Kre1p
transcript id: NM_001183160.1
SIO_010081: YNL322C
subclass of: SO_0000673
so part of: YNL322C
location: complement(<33294..>34235)
location: region:33294-34235:-1
so has part: feature:33294-34235:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:33294-34235:-1:exon

YNL322C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KRE1
locus tag: YNL322C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747]
note: Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
codon start: 1
product: Kre1p
translation: MMRRTLLHSFATLLLSLSLWSAAVMAAVTTQVTVVTNVAGALVTETTIWDPATAAAAATTTAQTGFFTTVFTTTNDVGTTVTLTQTVNRATMLPTTTTSTSSTGKTTTTVPTATSSLSSGLYLSTVTTTNDLGTTVTLTQTFTHSSTSATSSASSSVSSSVSSSGSSSSVKTTTSTGSAVAETGTRPDPSTDFTEPPVSAVTSLSIDSYITITEGTTSTYTTTRAPTSMWVTVVRQGNTITVQTTFVQRFSSQYVTVASPSVGSIGMGTLTGTVGVIKSAIKKTVSHNEAQHLGMSSFTSILGGLLTVLIWFL
SIO_010081: YNL322C
subclass of: SO_0000673
so part of: YNL322C
location: complement(33294..34235)
location: region:33294-34235:-1
so has part: feature:33294-34235:-1:exon

NP_014077.1
type: Protein
SIO_000068: ncbiprotein

S000005266
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:33294-34235:-1:exon

YNL321W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VNX1
locus tag: YNL321W
so part of: sequence
location: <34696..>37422
location: region:34696-37422:1
so has part: feature:34696-37422:1:exon
subclass of: SO_0000010

855395
type: Gene
SIO_000068: ncbigene

position:34696:1
position: 34696
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:37422:1
position: 37422
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34696-37422:1:exon

YNL321W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VNX1
locus tag: YNL321W
product: Vnx1p
transcript id: NM_001183159.1
SIO_010081: YNL321W
subclass of: SO_0000673
so part of: YNL321W
location: <34696..>37422
location: region:34696-37422:1
so has part: feature:34696-37422:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34696-37422:1:exon

YNL321W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VNX1
locus tag: YNL321W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17588950]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20709757|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:20578725]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]
experiment: EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:17588950]
experiment: EXISTENCE:mutant phenotype:GO:0006814 sodium ion transport [PMID:17588950]
experiment: EXISTENCE:mutant phenotype:GO:0015369 calcium:proton antiporter activity [PMID:20578725]
experiment: EXISTENCE:mutant phenotype:GO:0015385 sodium:proton antiporter activity [PMID:17588950]
experiment: EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:17588950]
experiment: EXISTENCE:mutant phenotype:GO:1902600 proton transmembrane transport [PMID:20578725]
note: Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway
codon start: 1
product: Vnx1p
translation: MAKNNHISASGNSTSGDHRLKEEVLTPTTSASTPHRIFSVDDDPKEIQNDIRYLEGLHEGLKFALHANKSKRSVSSQSPIVHSSNNTLHHHEHQQHLPPTLESLSSKSHSVPDLNTATPSSPKRMHSSIRELPHDDNDDEDANDDSRFIIHDSHGHDLLIDEINCQSPSHLENNDQASNASSTESFTLRERQDAINETHPFGIRIWKPALYKKHRSVQRTAAQDIHETQLKTITWEVTCSNVLWFILFGFPIAILFYSAAIVVFLLGGGGLVTNSAKEYSKCLYKLANYFLWPFGKMVYLLQDEQYLQEDKDEGISMQQFYNWVTSYSNRLVFHQSQAKFQQREDHPAPATESSSLMPPANTTATPLNSNHPSYNSIRHEIPHAAAQRRYFGRGKWSWGRVLFYTIFHLVLQPILAVLSLCLWLLVFTIPMSNVLWQIMYHCRRHPLALGFKYVENSSQSHENEITQQQLNKNILLCTFRAAGWHYYKYTVDGTNVIVVNLISIVFFTIFDFYVLKNFLHWKTWFTYESSIFILCLTSTIPLAFYIGQAVASISAQTSMGVGAVINAFFSTIVEIFLYCVALQQKKGLLVEGSMIGSILGAVLLLPGLSMCGGALNRKTQRYNPASAGVSSALLIFSMIVMFVPTVLYEIYGGYSVNCADGANDRDCTFSHPPLKFNRLFTHVIQPMSISCAIVLFCAYIIGLWFTLRTHAKMIWQLPIADPTSTAPEQQEQNSHDAPNWSRSKSTCILLMSTLLYAIIAEILVSCVDAVLEDIPSLNPKFLGLTIFALIPNTTEFLNAISFAIHGNVALSMEIGSAYALQVCLLQIPSLVIYSIFYTWNVKKSMINIRTQMFPLVFPRWDIFGAMTSVFMFTYLYAEGKSNYFKGSMLILLYIIIVVGFYFQGALSE
SIO_010081: YNL321W
subclass of: SO_0000673
so part of: YNL321W
location: 34696..37422
location: region:34696-37422:1
so has part: feature:34696-37422:1:exon

NP_014078.1
type: Protein
SIO_000068: ncbiprotein

S000005265
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34696-37422:1:exon

YNL320W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL320W
so part of: sequence
location: <37700..>38554
location: region:37700-38554:1
so has part: feature:37700-38554:1:exon
subclass of: SO_0000010

855396
type: Gene
SIO_000068: ncbigene

position:37700:1
position: 37700
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38554:1
position: 38554
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:37700-38554:1:exon

YNL320W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL320W
product: uncharacterized protein
transcript id: NM_001183158.1
SIO_010081: YNL320W
subclass of: SO_0000673
so part of: YNL320W
location: <37700..>38554
location: region:37700-38554:1
so has part: feature:37700-38554:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:37700-38554:1:exon

YNL320W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL320W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: uncharacterized protein
translation: MLWKVSKMFLGGLVALTTISVATLYHYQNRLVYPSWAQGARNHVDTPDSRGIPYEKLTLITQDHIKLEAWDIKNENSTSTVLILCPNAGNIGYFILIIDIFYRQFGMSVFIYSYRGYGNSEGSPSEKGLKLDADCVISHLSTDSFHSKRKLVLYGRSLGGANALYIASKFRDLCDGVILENTFLSIRKVIPYIFPLLKRFTLLCHEIWNSEGLMGSCSSETPFLFLSGLKDEIVPPFHMRKLYETCPSSNKKIFEFPLGSHNDTIIQDGYWDIIRDFLIEKGFI
SIO_010081: YNL320W
subclass of: SO_0000673
so part of: YNL320W
location: 37700..38554
location: region:37700-38554:1
so has part: feature:37700-38554:1:exon

NP_014079.1
type: Protein
SIO_000068: ncbiprotein

S000005264
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:37700-38554:1:exon

YNL318C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HXT14
locus tag: YNL318C
so part of: sequence
location: complement(<38707..>40329)
location: region:38707-40329:-1
so has part: feature:38707-40329:-1:exon
subclass of: SO_0000010

855398
type: Gene
SIO_000068: ncbigene

position:38707:-1
position: 38707
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:40329:-1
position: 40329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38707-40329:-1:exon

YNL318C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HXT14
locus tag: YNL318C
product: Hxt14p
transcript id: NM_001183156.1
SIO_010081: YNL318C
subclass of: SO_0000673
so part of: YNL318C
location: complement(<38707..>40329)
location: region:38707-40329:-1
so has part: feature:38707-40329:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:38707-40329:-1:exon

YNL318C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HXT14
locus tag: YNL318C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]
note: Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Hxt14p
translation: MTAQIPYQHSSGYISHFHNNELDAGRGRDYNVTIKYLDDKEENIEGQAAKISHNASLHIPVLLCLVISLGGFIFGWDIGTIGGMTNMVSFQEKFGTTNIIHDDETIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGDWIGRKGGIWFALVVYCIGITIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFGILMGNILNFICERCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKNDVPSAKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSLVKRNTFEFIMGKPKLWLRLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIKDPYITSIILSSVNFLSTILGIYYVEKWGHKTCLLYGSTNLLFYMMTYATVGTFGRETDFSNIVLIIVTCCFIFWFAITLGPVTFVLVSELFPLRTRAISMAICTFINWMFNFLISLLTPMIVSKIDFKLGYIFAACLLALIIFSWILVPETRKKNEQEINKIFEPE
SIO_010081: YNL318C
subclass of: SO_0000673
so part of: YNL318C
location: complement(38707..40329)
location: region:38707-40329:-1
so has part: feature:38707-40329:-1:exon

NP_014081.1
type: Protein
SIO_000068: ncbiprotein

S000005262
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38707-40329:-1:exon

YNL317W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PFS2
locus tag: YNL317W
so part of: sequence
location: <40619..>42016
location: region:40619-42016:1
so has part: feature:40619-42016:1:exon
subclass of: SO_0000010

855399
type: Gene
SIO_000068: ncbigene

position:40619:1
position: 40619
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42016:1
position: 42016
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40619-42016:1:exon

YNL317W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PFS2
locus tag: YNL317W
product: cleavage polyadenylation factor subunit PFS2
transcript id: NM_001183155.1
SIO_010081: YNL317W
subclass of: SO_0000673
so part of: YNL317W
location: <40619..>42016
location: region:40619-42016:1
so has part: feature:40619-42016:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40619-42016:1:exon

YNL317W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PFS2
locus tag: YNL317W
experiment: EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11344258]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11344258]
experiment: EXISTENCE:mutant phenotype:GO:0006378 mRNA polyadenylation [PMID:10619842]
experiment: EXISTENCE:mutant phenotype:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:10619842]
note: Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
codon start: 1
product: cleavage polyadenylation factor subunit PFS2
translation: MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI
SIO_010081: YNL317W
subclass of: SO_0000673
so part of: YNL317W
location: 40619..42016
location: region:40619-42016:1
so has part: feature:40619-42016:1:exon

NP_014082.1
type: Protein
SIO_000068: ncbiprotein

S000005261
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40619-42016:1:exon

YNL316C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHA2
locus tag: YNL316C
so part of: sequence
location: complement(<42071..>43075)
location: region:42071-43075:-1
so has part: feature:42071-43075:-1:exon
subclass of: SO_0000010

855400
type: Gene
SIO_000068: ncbigene

position:42071:-1
position: 42071
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:43075:-1
position: 43075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42071-43075:-1:exon

YNL316C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHA2
locus tag: YNL316C
product: prephenate dehydratase PHA2
transcript id: NM_001183154.1
SIO_010081: YNL316C
subclass of: SO_0000673
so part of: YNL316C
location: complement(<42071..>43075)
location: region:42071-43075:-1
so has part: feature:42071-43075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42071-43075:-1:exon

YNL316C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHA2
locus tag: YNL316C
EC number: 4.2.1.51
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004664 prephenate dehydratase activity [PMID:1532796]
experiment: EXISTENCE:mutant phenotype:GO:0009094 L-phenylalanine biosynthetic process [PMID:1532796]
note: Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
codon start: 1
product: prephenate dehydratase PHA2
translation: MASKTLRVLFLGPKGTYSHQAALQQFQSTSDVEYLPAASIPQCFNQLENDTSIDYSVVPLENSTNGQVVFSYDLLRDRMIKKALSLPAPADTNRITPDIEVIAEQYVPITHCLISPIQLPNGIASLGNFEEVIIHSHPQVWGQVECYLRSMAEKFPQVTFIRLDCSSTSESVNQCIRSSTADCDNILHLAIASETAAQLHKAYIIEHSINDKLGNTTRFLVLKRRENAGDNEVEDTGLLRVNLLTFTTRQDDPGSLVDVLNILKIHSLNMCSINSRPFHLDEHDRNWRYLFFIEYYTEKNTPKNKEKFYEDISDKSKQWCLWGTFPRNERYYHK
SIO_010081: YNL316C
subclass of: SO_0000673
so part of: YNL316C
location: complement(42071..43075)
location: region:42071-43075:-1
so has part: feature:42071-43075:-1:exon

NP_014083.2
type: Protein
SIO_000068: ncbiprotein

S000005260
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42071-43075:-1:exon

YNL315C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP11
locus tag: YNL315C
so part of: sequence
location: complement(<43324..>44280)
location: region:43324-44280:-1
so has part: feature:43324-44280:-1:exon
subclass of: SO_0000010

855401
type: Gene
SIO_000068: ncbigene

position:43324:-1
position: 43324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:44280:-1
position: 44280
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:43324-44280:-1:exon

YNL315C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP11
locus tag: YNL315C
product: Atp11p
transcript id: NM_001183153.1
SIO_010081: YNL315C
subclass of: SO_0000673
so part of: YNL315C
location: complement(<43324..>44280)
location: region:43324-44280:-1
so has part: feature:43324-44280:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:43324-44280:-1:exon

YNL315C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP11
locus tag: YNL315C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:1532796|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10681564|PMID:12829692]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:2142305]
experiment: EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:2142305]
experiment: EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:10681564]
note: Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo
codon start: 1
product: Atp11p
translation: MWRLTRKIGTRIHISNQLSPIFNKAIGTVPVFRFYSSSPEQKYRKKLLEEAQKQGFNSIEELKNHLKETIESKKREFNKIDPLKELEDYQQKTQMENNNSKHLMTKSRSPLDPSAPKVPFKTLDSFLDVGKLKDLSKQEVEFLWRARWAQKDNTLCAVIPVSVYDKMMANARNNPIFVLPLPRQVQSEDAKPNEEQGMELHYIQWQFVGPQTTHCMMTSLAEYKLHQEFARPHTTLQFHSDLVKDKGIVFMNGHVEPDTNVNVQDAQLLLLNVQRFYGAMGEETPVAKQRVQLLRDFSKASPGFTVEKLISLSQSMEN
SIO_010081: YNL315C
subclass of: SO_0000673
so part of: YNL315C
location: complement(43324..44280)
location: region:43324-44280:-1
so has part: feature:43324-44280:-1:exon

NP_014084.1
type: Protein
SIO_000068: ncbiprotein

S000005259
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:43324-44280:-1:exon

YNL314W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DAL82
locus tag: YNL314W
so part of: sequence
location: <44447..>45214
location: region:44447-45214:1
so has part: feature:44447-45214:1:exon
subclass of: SO_0000010

855402
type: Gene
SIO_000068: ncbigene

position:44447:1
position: 44447
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45214:1
position: 45214
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:44447-45214:1:exon

YNL314W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DAL82
locus tag: YNL314W
product: Dal82p
transcript id: NM_001183152.1
SIO_010081: YNL314W
subclass of: SO_0000673
so part of: YNL314W
location: <44447..>45214
location: region:44447-45214:1
so has part: feature:44447-45214:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:44447-45214:1:exon

YNL314W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DAL82
locus tag: YNL314W
experiment: EXISTENCE:curator inference:GO:0003700 DNA-binding transcription factor activity []
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10702289]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:8367295]
experiment: EXISTENCE:mutant phenotype:GO:0000256 allantoin catabolic process [PMID:1898922]
experiment: EXISTENCE:mutant phenotype:GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter [PMID:10906145]
experiment: EXISTENCE:mutant phenotype:GO:0043565 sequence-specific DNA binding [PMID:10702289]
experiment: EXISTENCE:physical interaction:GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter [PMID:10906145]
note: Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
codon start: 1
product: Dal82p
translation: MDESVDPVELLLRLLIRHKPHLKPYAYRQDSWQRVLDEYNRQTGSRYRQSRTLKTKFRRLKDLFSADRAQFSPSQLKLMGALLDEAPEHPRPRTKFGNESSSSLSSSSFIKSHPGPDPFQQLSSAEHPNNHSSDDEHSGSQPLPLDSITIGIPPTLHTIPMILSKDNDVGKVIKSPKINKGTNRFSETVLPPQMAAEQSWSDSNMELEICLDYLHNELEVIKKRQEDFECKVLNKLNIIEALLSQMRPPSQGDKI
SIO_010081: YNL314W
subclass of: SO_0000673
so part of: YNL314W
location: 44447..45214
location: region:44447-45214:1
so has part: feature:44447-45214:1:exon

NP_014085.1
type: Protein
SIO_000068: ncbiprotein

S000005258
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:44447-45214:1:exon

YNL313C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMW1
locus tag: YNL313C
so part of: sequence
location: complement(<45308..>48022)
location: region:45308-48022:-1
so has part: feature:45308-48022:-1:exon
subclass of: SO_0000010

855403
type: Gene
SIO_000068: ncbigene

position:45308:-1
position: 45308
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48022:-1
position: 48022
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45308-48022:-1:exon

YNL313C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMW1
locus tag: YNL313C
product: tetratricopeptide repeat-containing protein EMW1
transcript id: NM_001183151.1
SIO_010081: YNL313C
subclass of: SO_0000673
so part of: YNL313C
location: complement(<45308..>48022)
location: region:45308-48022:-1
so has part: feature:45308-48022:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45308-48022:-1:exon

YNL313C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMW1
locus tag: YNL313C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21273246|PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21273246|PMID:14562095|PMID:14690591]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:21273246]
note: Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
codon start: 1
product: tetratricopeptide repeat-containing protein EMW1
translation: METLLHAKLLLSAEVESLKSGSFDQTYVKKAEHIISGESYQLVQQFVDKFKGKISISGEISTSSVIAALNDFLNVEVFKMGQENEMLFLAIALLQTFIQNNYTGPAARLKAISGLFGKTGIEIGAVNTALSRSLAIMGQPAYEFMDDPLYLVLSLLLLERITGQKSLFDVTPDQEIPLPIISAESTPGLLAVAYWWWARALLTQLSLIPEPSGFQASVASAIYQSADLAYAITKELPESIHEDFKRELCAMYYLENVKCSLAINTEHLCLPSLTRAKKITNFEFVMTGARATRTKYQQKAHAGLIILAKSFTFQNFALRTTSATPETFALESDLLLEKPHFESIADEPLDEQIYSKRQKVDLNEGYEEDKLLPLALRQENIPKLLLDLNPNDQPTLSDYDNIQLLLRLYTIKNTTPAKDPLVEEELTALLSRILYQNGDKNWSIFARSLWERSIIETTKAKTIERGLLQMQSLVEELDLKIKSKLVPSSSEINVASRLSYIHQLPFIPRWQLDATLAEKYMSLGILKSAVEIYERLGMACETALCYAAVGDEKKAEEILLQRINENDSDARAYSILGDIKQDPSLWEKSWEIGKYVNAKNSLAKYYFNPPPKSGAQPNYSATLKHLNDSLRQYPLSFETWYFYGCVGLQCGKMQIAAEAFTRCVSLDPYHALSWSNLSAAYTKMDKLKEAYSCLKRAISCDAQKNWKIWENYMLVAVKLNEWEDVLTACKQLVSIRRDKSGEGSIDLPIIEKLVELLVTSEYPEEPQQLSYFQKSCTEFICNTLPQVITTSARCWRLVARVELWRKRPWAALECHEKAYRAISHNPDLEVEEKVWNDTVDACEDLVAAYESLGEMEGKYGPGSLVCKDWKYKCRSTIKALMSKGKGRWDDSPGWDRLVEARSQI
SIO_010081: YNL313C
subclass of: SO_0000673
so part of: YNL313C
location: complement(45308..48022)
location: region:45308-48022:-1
so has part: feature:45308-48022:-1:exon

NP_014086.1
type: Protein
SIO_000068: ncbiprotein

S000005257
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45308-48022:-1:exon

YNL312W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BUF1
alternative label: RPA2
alternative label: RPA32
gene: RFA2
locus tag: YNL312W
gene synonym: BUF1; RPA2; RPA32
so part of: sequence
location: <48287..>49216
location: region:48287-49216:1
so has part: feature:48287-49216:1:exon
subclass of: SO_0000010

855404
type: Gene
SIO_000068: ncbigene

position:48287:1
position: 48287
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:49216:1
position: 49216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48287-49216:1:exon

YNL312W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BUF1
alternative label: RPA2
alternative label: RPA32
gene: RFA2
locus tag: YNL312W
gene synonym: BUF1; RPA2; RPA32
product: Rfa2p
transcript id: NM_001183150.1
SIO_010081: YNL312W
subclass of: SO_0000673
so part of: YNL312W
location: join(<48287..48293,48402..>49216)
location: region:48287-49216:1
so has part: feature:48287-48293:1:exon
so has part: feature:48402-49216:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48287-48293:1:exon

position:48293:1
position: 48293
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:48402-49216:1:exon

position:48402:1
position: 48402
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL312W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BUF1
alternative label: RPA2
alternative label: RPA32
gene: RFA2
locus tag: YNL312W
gene synonym: BUF1; RPA2; RPA32
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8804316]
experiment: EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]
experiment: EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]
experiment: EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:2554144]
experiment: EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]
experiment: EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]
experiment: EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]
experiment: EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9093844]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9093844]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:8910442]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:14702040]
experiment: EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]
experiment: EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:14702040]
experiment: EXISTENCE:physical interaction:GO:0000722 telomere maintenance via recombination [PMID:2554144]
experiment: EXISTENCE:physical interaction:GO:0006312 mitotic recombination [PMID:2554144]
experiment: EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:2554144]
experiment: EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]
note: Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s
codon start: 1
product: Rfa2p
translation: MATYQPYNEYSSVTGGGFENSESRPGSGESETNTRVNTLTPVTIKQILESKQDIQDGPFVSHNQELHHVCFVGVVRNITDHTANIFLTIEDGTGQIEVRKWSEDANDLAAGNDDSSGKGYGSQVAQQFEIGGYVKVFGALKEFGGKKNIQYAVIKPIDSFNEVLTHHLEVIKCHSIASGMMKQPLESASNNNGQSLFVKDDNDTSSGSSPLQRILEFCKKQCEGKDANSFAVPIPLISQSLNLDETTVRNCCTTLTDQGFIYPTFDDNNFFAL
SIO_010081: YNL312W
subclass of: SO_0000673
so part of: YNL312W
location: join(48287..48293,48402..49216)
location: region:48287-49216:1
so has part: feature:48287-48293:1:exon
so has part: feature:48402-49216:1:exon

NP_014087.1
type: Protein
SIO_000068: ncbiprotein

S000005256
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48287-48293:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:48402-49216:1:exon

YNL311C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKP2
locus tag: YNL311C
so part of: sequence
location: complement(<49397..>51688)
location: region:49397-51688:-1
so has part: feature:49397-51688:-1:exon
subclass of: SO_0000010

855405
type: Gene
SIO_000068: ncbigene

position:49397:-1
position: 49397
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:51688:-1
position: 51688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:49397-51688:-1:exon

YNL311C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKP2
locus tag: YNL311C
product: putative SCF ubiquitin ligase complex subunit SKP2
transcript id: NM_001183149.1
SIO_010081: YNL311C
subclass of: SO_0000673
so part of: YNL311C
location: complement(<49397..>51688)
location: region:49397-51688:-1
so has part: feature:49397-51688:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:49397-51688:-1:exon

YNL311C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKP2
locus tag: YNL311C
experiment: EXISTENCE:curator inference:GO:0004842 ubiquitin-protein transferase activity [PMID:14747994]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:20936605]
experiment: EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:20936605]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]
note: F-box hypothetical protein; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
codon start: 1
product: putative SCF ubiquitin ligase complex subunit SKP2
translation: MKRLQLFGRSKYFSLVSSAAKEEEEEEEGCADAKSLLHSTSHDIKSRSLRFNDKSSLMCLPTKVLLLILRTLDFNTLVTLCQVNSRFYNLITNEFLFQNVILDSKLSLLKFNALIHSEFHTSNIVTHSGDCSTQSRSQNARFLVRSIEFKNPQSQDSLLKYSKFYNKSGQDSIIAGSYKLDSYDKDVKKLNNIRLNDETPIITSERIKLLDKLESNYFHYTYIELMLDIIDYLPNLTRVILSDVEPNFKIPLWYSVFNDGSRDFFKKIIKGQQSITNEDLRTFQLSKKFVKEYESKYYSLPRLKILEIKANNKRQRTFNRQRHHQKLVLRPSLFCCFGIINELKLENVTIDTESLDTPMEFLPLFLKNEDNELYSLQSPITALTLDSCDVVPGNGILRLFHSYFKMVKHLSLLKINSKFDLLLCSCFPSLSNLTIDCNSKCFTNEQVVGESYYFQQRSLDTEDDFDDCNSMTETLFEAPSDSKIITPPPTSSVVLSLNLNYISRTTGNDVSNNPSPDNNKKPAMLTAAQLQNFQRQRIPEFHSFYHYYRLLWERLPSKNISINVINIPFTNVYPLSPLSFWEHLARTITSVDETDEDVGDENDQETLIGYENNSIRDNIPNANAVPNLSTVMSPESDIHHTYYWNNSVRRCLRDSLIKLKNRTIEYRDLDVEEFLQNVTLENFFNDFQDPENFKDIPNINLWCFLRNLSKFKAVKIRMLRHFSLCTPRTRYDWELLLKPVLRVNVPIEVRDKDGFVLYSYGQK
SIO_010081: YNL311C
subclass of: SO_0000673
so part of: YNL311C
location: complement(49397..51688)
location: region:49397-51688:-1
so has part: feature:49397-51688:-1:exon

NP_014088.1
type: Protein
SIO_000068: ncbiprotein

S000005255
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:49397-51688:-1:exon

YNL310C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEP1
alternative label: TIM15
gene: ZIM17
locus tag: YNL310C
gene synonym: HEP1; TIM15
so part of: sequence
location: complement(<51907..>52431)
location: region:51907-52431:-1
so has part: feature:51907-52431:-1:exon
subclass of: SO_0000010

855406
type: Gene
SIO_000068: ncbigene

position:51907:-1
position: 51907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52431:-1
position: 52431
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:51907-52431:-1:exon

YNL310C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEP1
alternative label: TIM15
gene: ZIM17
locus tag: YNL310C
gene synonym: HEP1; TIM15
product: Zim17p
transcript id: NM_001183148.1
SIO_010081: YNL310C
subclass of: SO_0000673
so part of: YNL310C
location: complement(<51907..>52431)
location: region:51907-52431:-1
so has part: feature:51907-52431:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:51907-52431:-1:exon

YNL310C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEP1
alternative label: TIM15
gene: ZIM17
locus tag: YNL310C
gene synonym: HEP1; TIM15
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15992824|PMID:15383543]
experiment: EXISTENCE:direct assay:GO:0051087 chaperone binding [PMID:15719019]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15719019]
experiment: EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:15992824]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15719019]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15383543]
experiment: EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:16460754]
note: Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins
codon start: 1
product: Zim17p
translation: MIPRTRTLLQSKIPITRYFARCWAPRVRYNVCRTLPAAALHTNIIAHNEVKKDDKKVHLGSFKVDKPKMMIAFTCKKCNTRSSHTMSKQAYEKGTVLISCPHCKVRHLIADHLKIFHDHHVTVEQLMKANGEQVSQDVGDLEFEDIPDSLKDVLGKYAKNNSENASQLPHPSQK
SIO_010081: YNL310C
subclass of: SO_0000673
so part of: YNL310C
location: complement(51907..52431)
location: region:51907-52431:-1
so has part: feature:51907-52431:-1:exon

NP_014089.2
type: Protein
SIO_000068: ncbiprotein

S000005254
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:51907-52431:-1:exon

YNL309W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STB1
locus tag: YNL309W
so part of: sequence
location: <52662..>53924
location: region:52662-53924:1
so has part: feature:52662-53924:1:exon
subclass of: SO_0000010

855407
type: Gene
SIO_000068: ncbigene

position:52662:1
position: 52662
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:53924:1
position: 53924
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52662-53924:1:exon

YNL309W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STB1
locus tag: YNL309W
product: Stb1p
transcript id: NM_001183147.1
SIO_010081: YNL309W
subclass of: SO_0000673
so part of: YNL309W
location: <52662..>53924
location: region:52662-53924:1
so has part: feature:52662-53924:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:52662-53924:1:exon

YNL309W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STB1
locus tag: YNL309W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:18794370]
experiment: EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:18794370]
experiment: EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9393435]
experiment: EXISTENCE:genetic interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:10409718]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9393435]
experiment: EXISTENCE:mutant phenotype:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:18794370]
experiment: EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:10409718|PMID:12832490|PMID:18794370]
experiment: EXISTENCE:physical interaction:GO:0070822 Sin3-type complex [PMID:9393435]
note: Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication
codon start: 1
product: Stb1p
translation: MSQPQMSPEKEQELASKILHRAELAQMTRQLKLGLSNVPSTKRKQDSTTKKRSGEDAEDVDEDHKTLLEAISPAKKPLHDDTNKMTVISPVKFVEKPNTPPSSRQRKAEDRSQQIKPRKEDTPSTPRASATPIILPHASSHYQRPHDKNFMTPKRNNNNSSNHSNNNNNIKKKAAGSKDAPQDSDNTAGADLLMYLATSPYNKSSHHGTPMAVRMPTTPRSYHYASQLSLNGNTASTSNDAVRFSHIKPSASSPQSTFKSNLLPNFPDESLMDSPSLYLSNNNGSVQATLSPQQRRKPTTNTLHPPSNVPTTPSRELNGTNFNLLRTPNFNMGDYLHNLFSPSPRVPAQQGASNTSASIPSVPAMVPGSSSNTSAIATAAISSHTTNNFLDMNANGIPLIVGPGTDRIGEGESIDDKLTD
SIO_010081: YNL309W
subclass of: SO_0000673
so part of: YNL309W
location: 52662..53924
location: region:52662-53924:1
so has part: feature:52662-53924:1:exon

NP_014090.2
type: Protein
SIO_000068: ncbiprotein

S000005253
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52662-53924:1:exon

YNL308C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KRI1
locus tag: YNL308C
so part of: sequence
location: complement(<54122..>55897)
location: region:54122-55897:-1
so has part: feature:54122-55897:-1:exon
subclass of: SO_0000010

855408
type: Gene
SIO_000068: ncbigene

position:54122:-1
position: 54122
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55897:-1
position: 55897
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54122-55897:-1:exon

YNL308C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KRI1
locus tag: YNL308C
product: Kri1p
transcript id: NM_001183146.1
SIO_010081: YNL308C
subclass of: SO_0000673
so part of: YNL308C
location: complement(<54122..>55897)
location: region:54122-55897:-1
so has part: feature:54122-55897:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54122-55897:-1:exon

YNL308C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KRI1
locus tag: YNL308C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11027267]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22180534]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11027267]
note: Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p
codon start: 1
product: Kri1p
translation: MPRKKSAAKRAREQAKKEAAVPATDTATIKTSETSATTVKPAIEASKSYVPSEDEEEDEEEEEEEDDYGELITDEVENGINQVLDAIKNNKTDKLLDPKVKFFEDPESAAAKLANREGKHKPIYLKDYHRMNILSGDALKEDDEEYEHATVDGKQSFVSQQREEKTQLLNEIKSAFSDEENEESSGDEDDGFLKKKEPSTKKEGKNLPDPTVNEENFLEEFVNQQAWIPKKGDKVISLDLNNNEEDDEEFEDAAEKFENAYNFRYEDPNAAEIISYARSQATLRRSDDSSRRRKREEKRKIKEQIKAEKETALQKKKTKKLNKLTDILEQLTKEYGAEINADMVKKITDTLLKNDFKEEEWDNVVAELFNEEFYQQEGKPTWNEDDEIMGDFYADADGDDQTEEGEVEKEQKEEDEEEGPKRKKSKKEEKLQKKKEKRKVNELVENALEQNKLALIEEVEKEEEERKSRSRTKEEQDLKFRYREVSPESFGLTAREIFAADDTDLNEFIGLKKFAPYRSKELRAKDKRKVMKARRLREWRKKTFKNENGLAPVEAEAGEKDEDTILIPVEKASKSKHKRGHSHKHKGHQKK
SIO_010081: YNL308C
subclass of: SO_0000673
so part of: YNL308C
location: complement(54122..55897)
location: region:54122-55897:-1
so has part: feature:54122-55897:-1:exon

NP_014091.1
type: Protein
SIO_000068: ncbiprotein

S000005252
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54122-55897:-1:exon

YNL307C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CMS1
alternative label: YPK1
gene: MCK1
locus tag: YNL307C
gene synonym: CMS1; YPK1
so part of: sequence
location: complement(<56446..>57573)
location: region:56446-57573:-1
so has part: feature:56446-57573:-1:exon
subclass of: SO_0000010

855409
type: Gene
SIO_000068: ncbigene

position:56446:-1
position: 56446
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:57573:-1
position: 57573
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56446-57573:-1:exon

YNL307C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CMS1
alternative label: YPK1
gene: MCK1
locus tag: YNL307C
gene synonym: CMS1; YPK1
product: serine/threonine/tyrosine protein kinase MCK1
transcript id: NM_001183145.1
SIO_010081: YNL307C
subclass of: SO_0000673
so part of: YNL307C
location: complement(<56446..>57573)
location: region:56446-57573:-1
so has part: feature:56446-57573:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56446-57573:-1:exon

YNL307C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CMS1
alternative label: YPK1
gene: MCK1
locus tag: YNL307C
gene synonym: CMS1; YPK1
EC number: 2.7.12.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:23314252]
experiment: EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:8407952]
experiment: EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:17954914|PMID:23236290]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:36321416]
experiment: EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:2010084]
experiment: EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:22918234]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:17954914|PMID:23236290]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2010083]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:2010083]
experiment: EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:22918234]
note: Dual-specificity S/T and tyrosine protein kinase; spindle position checkpoint component that works in parallel with Kin4p to prevent mitotic exit network (MEN) activation by the Cdc14 early anaphase release (FEAR) network; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent degradation of Rcn1p and Cdc6p, inhibition of protein kinase A, transcriptional regulation, inhibition of RNAPIII, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division
codon start: 1
product: serine/threonine/tyrosine protein kinase MCK1
translation: MSTEEQNGVPLQRGSEFIADDVTSNKSNNTRRMLVKEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKSRELQILRIADHPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDDTFLPRGFTEPIKLPNLFDFNDFELQILGEFADKIKPTKVAE
SIO_010081: YNL307C
subclass of: SO_0000673
so part of: YNL307C
location: complement(56446..57573)
location: region:56446-57573:-1
so has part: feature:56446-57573:-1:exon

NP_014092.1
type: Protein
SIO_000068: ncbiprotein

S000005251
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56446-57573:-1:exon

YNL306W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uS11m
gene: MRPS18
locus tag: YNL306W
gene synonym: uS11m
so part of: sequence
location: <58155..>58808
location: region:58155-58808:1
so has part: feature:58155-58808:1:exon
subclass of: SO_0000010

855410
type: Gene
SIO_000068: ncbigene

position:58155:1
position: 58155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58808:1
position: 58808
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58155-58808:1:exon

YNL306W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uS11m
gene: MRPS18
locus tag: YNL306W
gene synonym: uS11m
product: mitochondrial 37S ribosomal protein YmS18
transcript id: NM_001183144.1
SIO_010081: YNL306W
subclass of: SO_0000673
so part of: YNL306W
location: <58155..>58808
location: region:58155-58808:1
so has part: feature:58155-58808:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:58155-58808:1:exon

YNL306W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uS11m
gene: MRPS18
locus tag: YNL306W
gene synonym: uS11m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]
note: Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
codon start: 1
product: mitochondrial 37S ribosomal protein YmS18
translation: MLLQPVWKGCRWTQFVRPIRRWNSTGTNRGVPFSFKDISNQEDITNISYPSSSDSVLTKSNGSSEVYKPKEEVVKYILHGKFTKNNTHLTFSSVVEDKNFHKNKGLTYNDTMLYYLNLPQKVKISLSTGCLGFRKAARGEYEAAFQTSGRMFELIKEKNMLNKDIEVVMDDFGKGRAAFISALVGKEGASVVKKVVKISDATKLKFGGVRSPKMRRL
SIO_010081: YNL306W
subclass of: SO_0000673
so part of: YNL306W
location: 58155..58808
location: region:58155-58808:1
so has part: feature:58155-58808:1:exon

NP_014093.1
type: Protein
SIO_000068: ncbiprotein

S000005250
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:58155-58808:1:exon

YNL305C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YBH3
gene: BXI1
locus tag: YNL305C
gene synonym: YBH3
so part of: sequence
location: complement(<58898..>59791)
location: region:58898-59791:-1
so has part: feature:58898-59791:-1:exon
subclass of: SO_0000010

855411
type: Gene
SIO_000068: ncbigene

position:58898:-1
position: 58898
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:59791:-1
position: 59791
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58898-59791:-1:exon

YNL305C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YBH3
gene: BXI1
locus tag: YNL305C
gene synonym: YBH3
product: Bxi1p
transcript id: NM_001183143.1
SIO_010081: YNL305C
subclass of: SO_0000673
so part of: YNL305C
location: complement(<58898..>59791)
location: region:58898-59791:-1
so has part: feature:58898-59791:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:58898-59791:-1:exon

YNL305C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YBH3
gene: BXI1
locus tag: YNL305C
gene synonym: YBH3
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:21673659|PMID:21673967|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21673659]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21673967]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:21673659|PMID:21673967]
experiment: EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:21673967]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:21673967]
note: Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
codon start: 1
product: Bxi1p
translation: MSGPPPPYEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIFRKVYPDEEVRCAMMLYLDIVNLFLSILRILANSNDDN
SIO_010081: YNL305C
subclass of: SO_0000673
so part of: YNL305C
location: complement(58898..59791)
location: region:58898-59791:-1
so has part: feature:58898-59791:-1:exon

NP_014094.1
type: Protein
SIO_000068: ncbiprotein

S000005249
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:58898-59791:-1:exon

YNL304W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPT11
locus tag: YNL304W
so part of: sequence
location: <60297..>61550
location: region:60297-61550:1
so has part: feature:60297-61550:1:exon
subclass of: SO_0000010

855412
type: Gene
SIO_000068: ncbigene

position:60297:1
position: 60297
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:61550:1
position: 61550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:60297-61550:1:exon

YNL304W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPT11
locus tag: YNL304W
product: Rab family GTPase YPT11
transcript id: NM_001183142.1
SIO_010081: YNL304W
subclass of: SO_0000673
so part of: YNL304W
location: <60297..>61550
location: region:60297-61550:1
so has part: feature:60297-61550:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:60297-61550:1:exon

YNL304W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPT11
locus tag: YNL304W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12391144]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:23427260]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16980630|PMID:23427260]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12391144|PMID:23427260]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12391144|PMID:23427260]
experiment: EXISTENCE:direct assay:GO:0048309 endoplasmic reticulum inheritance [PMID:23427260]
experiment: EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:23427260]
experiment: EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:12391144|PMID:15201867]
experiment: EXISTENCE:genetic interaction:GO:0048313 Golgi inheritance [PMID:18595704]
experiment: EXISTENCE:genetic interaction:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:18245340]
experiment: EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:16980630|PMID:23427260]
experiment: EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:12391144]
experiment: EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:18595704]
experiment: EXISTENCE:mutant phenotype:GO:0051646 mitochondrion localization [PMID:23139336]
experiment: EXISTENCE:mutant phenotype:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]
experiment: EXISTENCE:physical interaction:GO:0031489 myosin V binding [PMID:12391144]
note: Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed
codon start: 1
product: Rab family GTPase YPT11
translation: MSQRKRYSLNVVTSPSIPSPTPSAPIRTNESNWEAASPASAASSFLPNVHHGGTVLNPGLGIMRSPSLNKSGAFGRSGSSGSSTVIEPSNIKLLLIGDANVGKTAMILSYCRELLTRAEMSRSARLRHQQQQQHKDLGLKKTVVNHRLSMKEKRKRYSSNDFEKEFKDINHFADETSDFGNPNIGDDNNHEMADPNEIVIETRSTIGIDIKTNLVNIDNRFFNVILWDTAGQERYQNAIIPSLYKKTNAVILTYDITNAKSFQSCMERWIVQALENFSSQDLLKARFFLVGNKIDLYKERQVTHYDVVQMVQEMQLKHGIKISGNFEVSCKWVNVVERTMNMIILDLVENGCFENNDPCVSITTSDDVQGHEQEFHDTVEEPFNFTRQRQHQLEKNNTVDITKPNDDIANNQSICCV
SIO_010081: YNL304W
subclass of: SO_0000673
so part of: YNL304W
location: 60297..61550
location: region:60297-61550:1
so has part: feature:60297-61550:1:exon

NP_014095.2
type: Protein
SIO_000068: ncbiprotein

S000005248
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:60297-61550:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1406; Autonomously Replicating Sequence
so part of: sequence
location: 61599..61895
location: region:61599-61895:1
so has part: feature:61599-61895:1:region

S000118383
type: SGD
SIO_000068: sgd

position:61599:1
position: 61599
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:61895:1
position: 61895
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61599-61895:1:region

YNL302C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RP55B
gene: RPS19B
locus tag: YNL302C
gene synonym: RP55B
so part of: sequence
location: complement(<61958..>62943)
location: region:61958-62943:-1
so has part: feature:61958-62943:-1:exon
subclass of: SO_0000010

855414
type: Gene
SIO_000068: ncbigene

position:61958:-1
position: 61958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:62943:-1
position: 62943
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61958-62943:-1:exon

YNL302C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RP55B
gene: RPS19B
locus tag: YNL302C
gene synonym: RP55B
product: ribosomal 40S subunit protein S19B
transcript id: NM_001183140.1
SIO_010081: YNL302C
subclass of: SO_0000673
so part of: YNL302C
location: complement(join(<61958..62372,62924..>62943))
location: region:61958-62943:-1
so has part: feature:62924-62943:-1:exon
so has part: feature:61958-62372:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:62924-62943:-1:exon

position:62924:-1
position: 62924
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:61958-62372:-1:exon

position:62372:-1
position: 62372
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL302C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RP55B
gene: RPS19B
locus tag: YNL302C
gene synonym: RP55B
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16159874|PMID:16246728]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:16159874]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]
note: Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S19B
translation: MAGVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSSGNEMPPQDAEGWFYKRAASVARHIYMRKQVGVGKLNKLYGGAKSRGVRPYKHIDASGSINRKVLQALEKIGIVEISPKGGRRISENGQRDLDRIAAQTLEEDE
SIO_010081: YNL302C
subclass of: SO_0000673
so part of: YNL302C
location: complement(join(61958..62372,62924..62943))
location: region:61958-62943:-1
so has part: feature:62924-62943:-1:exon
so has part: feature:61958-62372:-1:exon

NP_014097.1
type: Protein
SIO_000068: ncbiprotein

S000005246
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62924-62943:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:61958-62372:-1:exon

YNL301C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RP28B
gene: RPL18B
locus tag: YNL301C
gene synonym: RP28B
so part of: sequence
location: complement(<63570..>64562)
location: region:63570-64562:-1
so has part: feature:63570-64562:-1:exon
subclass of: SO_0000010

855415
type: Gene
SIO_000068: ncbigene

position:63570:-1
position: 63570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:64562:-1
position: 64562
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:63570-64562:-1:exon

YNL301C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RP28B
gene: RPL18B
locus tag: YNL301C
gene synonym: RP28B
product: ribosomal 60S subunit protein L18B
transcript id: NM_001183139.1
SIO_010081: YNL301C
subclass of: SO_0000673
so part of: YNL301C
location: complement(join(<63570..64018,64451..>64562))
location: region:63570-64562:-1
so has part: feature:64451-64562:-1:exon
so has part: feature:63570-64018:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:64451-64562:-1:exon

position:64451:-1
position: 64451
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:63570-64018:-1:exon

position:64018:-1
position: 64018
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL301C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RP28B
gene: RPL18B
locus tag: YNL301C
gene synonym: RP28B
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L18B
translation: MGIDHTSKQHKRSGHRTAPKSDNVYLKLLVKLYTFLARRTDAPFNKVVLKALFLSKINRPPVSVSRIARALKQEGAANKTVVVVGTVTDDARIFEFPKTTVAALRFTAGARAKIVKAGGECITLDQLAVRAPKGQNTLILRGPRNSREAVRHFGMGPHKGKAPRILSTGRKFERARGRRRSKGFKV
SIO_010081: YNL301C
subclass of: SO_0000673
so part of: YNL301C
location: complement(join(63570..64018,64451..64562))
location: region:63570-64562:-1
so has part: feature:64451-64562:-1:exon
so has part: feature:63570-64018:-1:exon

NP_014098.1
type: Protein
SIO_000068: ncbiprotein

S000005245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:64451-64562:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:63570-64018:-1:exon

YNL300W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOS6
locus tag: YNL300W
so part of: sequence
location: <65744..>66052
location: region:65744-66052:1
so has part: feature:65744-66052:1:exon
subclass of: SO_0000010

855416
type: Gene
SIO_000068: ncbigene

position:65744:1
position: 65744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:66052:1
position: 66052
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:65744-66052:1:exon

YNL300W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOS6
locus tag: YNL300W
product: Tos6p
transcript id: NM_001183138.1
SIO_010081: YNL300W
subclass of: SO_0000673
so part of: YNL300W
location: <65744..>66052
location: region:65744-66052:1
so has part: feature:65744-66052:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:65744-66052:1:exon

YNL300W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOS6
locus tag: YNL300W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
note: Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
codon start: 1
product: Tos6p
translation: MKFSTLSTVAAIAAFASADSTSDGVTYVDVTTTPQSTTSMVSTVKTTSTPYTTSTIATLSTKSISSQANTTTHEISTYVGAAVKGSVAGMGAIMGAAAFALL
SIO_010081: YNL300W
subclass of: SO_0000673
so part of: YNL300W
location: 65744..66052
location: region:65744-66052:1
so has part: feature:65744-66052:1:exon

NP_014099.1
type: Protein
SIO_000068: ncbiprotein

S000005244
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:65744-66052:1:exon

YNL299W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRF5
locus tag: YNL299W
so part of: sequence
location: <66517..>68445
location: region:66517-68445:1
so has part: feature:66517-68445:1:exon
subclass of: SO_0000010

855417
type: Gene
SIO_000068: ncbigene

position:66517:1
position: 66517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:68445:1
position: 68445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:66517-68445:1:exon

YNL299W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRF5
locus tag: YNL299W
product: non-canonical poly(A) polymerase TRF5
transcript id: NM_001183137.1
SIO_010081: YNL299W
subclass of: SO_0000673
so part of: YNL299W
location: <66517..>68445
location: region:66517-68445:1
so has part: feature:66517-68445:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:66517-68445:1:exon

YNL299W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRF5
locus tag: YNL299W
EC number: 2.7.7.19
experiment: EXISTENCE:direct assay:GO:0004652 polynucleotide adenylyltransferase activity [PMID:16260630|PMID:16374505]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:16374505]
experiment: EXISTENCE:genetic interaction:GO:0004652 polynucleotide adenylyltransferase activity [PMID:16374505]
experiment: EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0043629 ncRNA polyadenylation [PMID:16373491|PMID:16374505|PMID:16431988]
experiment: EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:17652137]
experiment: EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758|PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]
experiment: EXISTENCE:genetic interaction:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:16431988]
experiment: EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18007593]
experiment: EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491]
experiment: EXISTENCE:genetic interaction:GO:0071044 histone mRNA catabolic process [PMID:17179095]
experiment: EXISTENCE:genetic interaction:GO:0071050 sno(s)RNA polyadenylation [PMID:18951092]
experiment: EXISTENCE:genetic interaction:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0004652 polynucleotide adenylyltransferase activity [PMID:16374505]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:18007593]
note: Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
codon start: 1
product: non-canonical poly(A) polymerase TRF5
translation: MTRLKAKYSPTKGKRKEDKHTKRMRKSSFTRTQKMLEVFNDNRSHFNKYESLAIDVEDDDTFGNLVLMENDKSDVDIPVIEEVTSSEDEQRAESSKRNNSLEDNQDFIAFSDSSEDETEQIKEDDDERSSFLLTDEHEVSKLTSQQSLNTESACNVEYPWIRNHCHSKQRRIADWLTSEIKDFVHYISPSKNEIKCRNRTIDKLRRAVKELWSDADLHVFGSFATDLYLPGSDIDCVVNSRNRDKEDRNYIYELARHLKNKGLAIRMEVIVKTRVPIIKFIEPQSQLHIDVSFERTNGLEAAKLIREWLRDSPGLRELVLIIKQFLHSRRLNNVHTGGLGGFTVICLVYSFLNMHPRIKSNDIDVLDNLGVLLIDFFELYGKNFGYDDVAISISDGYASYIPKSCWRTLEPSRSKFSLAIQDPGDPNNNISRGSFNMKDIKKAFAGAFELLVNKCWELNSATFKDRVGKSILGNVIKYRGQKRDFNDERDLVQNKAIIENERYHKRRTRIVQEDLFINDTEDLPVEEIYKLDEPAKKKQKAKKDKREGEIKKSAIPSPPPDFGVSRSKLKRKVKKTDQGSLLHQNNLSIDDLMGLSENDQESDQDQKGRDTPSGQDEKSPLETKTVDAQTRRDYWLSKGQAL
SIO_010081: YNL299W
subclass of: SO_0000673
so part of: YNL299W
location: 66517..68445
location: region:66517-68445:1
so has part: feature:66517-68445:1:exon

NP_014100.2
type: Protein
SIO_000068: ncbiprotein

S000005243
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:66517-68445:1:exon

YNL298W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ERC10
gene: CLA4
locus tag: YNL298W
gene synonym: ERC10
so part of: sequence
location: <68915..>71443
location: region:68915-71443:1
so has part: feature:68915-71443:1:exon
subclass of: SO_0000010

855418
type: Gene
SIO_000068: ncbigene

position:68915:1
position: 68915
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:71443:1
position: 71443
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:68915-71443:1:exon

YNL298W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ERC10
gene: CLA4
locus tag: YNL298W
gene synonym: ERC10
product: serine/threonine protein kinase CLA4
transcript id: NM_001183136.1
SIO_010081: YNL298W
subclass of: SO_0000673
so part of: YNL298W
location: <68915..>71443
location: region:68915-71443:1
so has part: feature:68915-71443:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:68915-71443:1:exon

YNL298W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ERC10
gene: CLA4
locus tag: YNL298W
gene synonym: ERC10
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:19218422]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22588722]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:19218422]
experiment: EXISTENCE:direct assay:GO:0016301 kinase activity [PMID:14993234]
experiment: EXISTENCE:direct assay:GO:0019899 enzyme binding [PMID:31395335]
experiment: EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:19218422]
experiment: EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:genetic interaction:GO:0019236 response to pheromone [PMID:17189484]
experiment: EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:7649470]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:19218422]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]
experiment: EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:11025657]
experiment: EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:22588722]
note: Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase CLA4
translation: MSLSAAANKISDNDFQNIGPAPRPPSSNSQGRTCYNQTQPITKLMSQLDLTSASHLGTSTSKKKSGWVSYKDDGILSFIWQKRYLMLHDSYVALYKNDKQNDDAILKIPLTSIISVSRTQLKQYCFELVRCSDRNSVSSGSSSSLNVSSDSNSKKSIYIATKTESDLHSWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQPPNTKSPVSLGSGSLPPINTKLPTSQSNIPRHLQNVPNQQYPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQQQQQQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAIPRYAQNSSPTAAHFQPQRTAPKPPISAPRAPYPSNQNATSNTHVQPVAPKNDQSTPQTMRQAPKRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSLLEWKE
SIO_010081: YNL298W
subclass of: SO_0000673
so part of: YNL298W
location: 68915..71443
location: region:68915-71443:1
so has part: feature:68915-71443:1:exon

NP_014101.1
type: Protein
SIO_000068: ncbiprotein

S000005242
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:68915-71443:1:exon

YNL297C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YSL2
gene: MON2
locus tag: YNL297C
gene synonym: YSL2
so part of: sequence
location: complement(<71673..>76583)
location: region:71673-76583:-1
so has part: feature:71673-76583:-1:exon
subclass of: SO_0000010

855420
type: Gene
SIO_000068: ncbigene

position:71673:-1
position: 71673
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:76583:-1
position: 76583
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:71673-76583:-1:exon

YNL297C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YSL2
gene: MON2
locus tag: YNL297C
gene synonym: YSL2
product: Mon2p
transcript id: NM_001183135.1
SIO_010081: YNL297C
subclass of: SO_0000673
so part of: YNL297C
location: complement(<71673..>76583)
location: region:71673-76583:-1
so has part: feature:71673-76583:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:71673-76583:-1:exon

YNL297C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YSL2
gene: MON2
locus tag: YNL297C
gene synonym: YSL2
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:12052896]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16301316]
experiment: EXISTENCE:direct assay:GO:0006623 protein targeting to vacuole [PMID:16219684]
experiment: EXISTENCE:direct assay:GO:0031901 early endosome membrane [PMID:16219684]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12052896]
experiment: EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16301316]
experiment: EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]
note: Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins
codon start: 1
product: Mon2p
translation: MAMNTGGFDSMQRQLEAELRSLSSESKRRNSTIRHASDKSIEILKRVHSFEELERHPDFALPFVLACQSRNAKMTTLAMQCLQGLSTVPSIPRSRLSEILDAFIEATHLAMEIQLKVLQVVPIFFKTYGKFIYGPLCKKLLLCCSNLLHVPNKAPVVVGTASATLQQLIDEIFDRLSIESVVDDKQYEVLISNSESIKVNVYRYDANKLFDNICSLNEISSNGAVSDEEMLLDIGDIPIDYGLEILESILKNSQKNLLECQDLQYLLRVKAIPLLLRCISSSRHFSTAVRSCRCLKLLIRKEYLSILELELEVILSLLIHGISVESNLSGWQRVLSLELFKDLSQDPEIVNTLYMDYDNYPDKKHVFKYLLKECIVLLNSPEYITFLAPSKVVEKMDSPLITTENSTVKTKFMHLLDKSNAPSINITYIISLILTICNHLCEGLNKSALESSPLEKKIEDKEREEGTGNDSTVVKVYSGLFSGLFELNKLFLYSTSLETSIFHLVVRAFQKLAHSAGVLSLKDKLRACMKLFSILITNNVTSSNQYSFNDTSKSAKNQHTRNISTSSVTTSPVESTKNPSRSIADSAQNKEMKRRLHPRNISSRQVSLLRALISLSISLGPIFDSESWRYTFLTWQWITYYIYGPSADFKESFYSEDIPPPPILTKSDVTSIESSLTKFFESTSSYSCSTFHLVLTRLILDSKNTLTLEQTNLNLNNDIGYHPLDAKDEIIPCIYNKAFFVNKIGELATYNCKKFLFGKNGKELWSLISTYMIKLISNREMDNDSLRLYTVRVFTDIIKKATNEVGNSDEQDNKVKQFGTLENLVIDSLMATINSIKQLDIGKQEIYNGTINVESDILFQLLLTLKEILNEFGELLMNSWTNIFNIINSPFEWTVEDTDFSVNEDIDDSSLFEGIVQKHKNMIQVSYDVFKLISDDFLQSLPMSVIKFVIDTLVNFVSQKRNLNISFSSISQFWLVGDYLRVRFNPETLNLSDEKRRSLSEKINNQKLIEIITSSSSHDWELYNGLWIYLLKNLINCTNDDRVEVKNGAVQTFFRIIDSHSVCFPPWDLIFLEVIEPLLTKEWSTEELENETDFINVTLQGLIKLYPEHFKDFKNNTTCAKEWSMLLDFLKRLLSSTSNNTKNAVILNYQTLLKEIITIEDVPSDILKKCCEIFTDYNITYSDLSTNASSKTEYDCIYELITGFPPLYQLISKYDAMTDEFVEKVLLLFNSAIKYPLLPEFVQDKTKPSSMQKAILSGLDIFMTNDSKDTEILILLQLSTISILAFDTREKITKKLGPKLPKASLNRLPTFEAISYMSCSNLRNRIAKIDQFGISTLKAKHILRILKNLAEIIKRKSLITGSESDEIPIWVLASNCFCDLSNKIFKSLQEDAENPLKDNFCDLFINVIVVTLQRINPELDNLTEIDDLNEYSKYREILLENRIIDLFNERQLDTFIYAVWDCSFLYEFDELENALMQDCGTFSELSQKLSSFDFSCIFGSTTNPRFQTKYKCSLECLQDLVNFMLNTNEKLRKLTAPYLSARIALALRRYISDEYLIGRAPIPKLRKTELATLLNGLCVILRGVLDQNSTLGNKQIGVENLQTLSPLILRTIPVSHKMDGLQDKVLELSLGFTKLD
SIO_010081: YNL297C
subclass of: SO_0000673
so part of: YNL297C
location: complement(71673..76583)
location: region:71673-76583:-1
so has part: feature:71673-76583:-1:exon

NP_014102.1
type: Protein
SIO_000068: ncbiprotein

S000005241
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:71673-76583:-1:exon

YNL295W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRX6
locus tag: YNL295W
so part of: sequence
location: <76946..>78520
location: region:76946-78520:1
so has part: feature:76946-78520:1:exon
subclass of: SO_0000010

855421
type: Gene
SIO_000068: ncbigene

position:76946:1
position: 76946
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:78520:1
position: 78520
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:76946-78520:1:exon

YNL295W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRX6
locus tag: YNL295W
product: Mrx6p
transcript id: NM_001183133.1
SIO_010081: YNL295W
subclass of: SO_0000673
so part of: YNL295W
location: <76946..>78520
location: region:76946-78520:1
so has part: feature:76946-78520:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:76946-78520:1:exon

YNL295W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRX6
locus tag: YNL295W
experiment: EXISTENCE:direct assay:GO:0000262 mitochondrial chromosome [PMID:31532710]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:31532710]
experiment: EXISTENCE:mutant phenotype:GO:0090144 mitochondrial nucleoid organization [PMID:31532710]
experiment: EXISTENCE:mutant phenotype:GO:1901858 regulation of mitochondrial DNA metabolic process [PMID:31532710]
note: Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA
codon start: 1
product: Mrx6p
translation: MEHQALRRLVLYCPNFIRRGALRQNMTRVSCRHMSGKGGGRDEKGDCNEEKDSSKDLGRVPSKMKRAYDGETVIKEGDSHAESLAQQGKQPTDLAYNSRSKISGSNLHLLVPRVASTDYISNKEVHTEGLFAGYRPLFLGNSGFPSDARKGKNFHELDDVLPNIQVVDASEKDGKLNVQEIIEDLQRTSLRESIHSMEQLPSSHKRKPVIPWDASISGMVYNDMPFKYVPKNIILKMKPFKLLRIERKSQAKNARKPTMIKLQFHNRRINDTPELVNLYHNKSRLHESLYNTKPLQESGYSSANTSKRQKMLKARSDFEHKQKNYAYKHTFIKNDQELFRNELTKLNKILAREFKKLTKLSIHNEFKREHLPLAVYVSKSKGTKKLFRRSLKMKIMDHIYPVYTTILSTLTNSRDSKKFENKIKAYIEKIIVRLSDEVPSTYFFQDGVDCIIQPSPIHNFKRMHWLRYTKRHNTFWGRTIHKDVQVSFNDKYVVTRSGVRYTRYPTNLNTQLLETAFEEWDYYE
SIO_010081: YNL295W
subclass of: SO_0000673
so part of: YNL295W
location: 76946..78520
location: region:76946-78520:1
so has part: feature:76946-78520:1:exon

NP_014104.1
type: Protein
SIO_000068: ncbiprotein

S000005239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:76946-78520:1:exon

YNL294C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAL2
gene: RIM21
locus tag: YNL294C
gene synonym: PAL2
so part of: sequence
location: complement(<78659..>80260)
location: region:78659-80260:-1
so has part: feature:78659-80260:-1:exon
subclass of: SO_0000010

855422
type: Gene
SIO_000068: ncbigene

position:78659:-1
position: 78659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80260:-1
position: 80260
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78659-80260:-1:exon

YNL294C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAL2
gene: RIM21
locus tag: YNL294C
gene synonym: PAL2
product: Rim21p
transcript id: NM_001183132.1
SIO_010081: YNL294C
subclass of: SO_0000673
so part of: YNL294C
location: complement(<78659..>80260)
location: region:78659-80260:-1
so has part: feature:78659-80260:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78659-80260:-1:exon

YNL294C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAL2
gene: RIM21
locus tag: YNL294C
gene synonym: PAL2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]
experiment: EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]
experiment: EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10821185]
experiment: EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10821185]
experiment: EXISTENCE:mutant phenotype:GO:0070613 regulation of protein processing [PMID:27803246]
experiment: EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:23019326]
experiment: EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:27803246]
note: pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
codon start: 1
product: Rim21p
translation: MNLWRHSPEELAAYNSCHPMKLGSGVLIQLPLYDNSAVYAEDITFRSFCCERVPVYVSTVLRNSSPYRYLDEVINDWQKFIQVSDYVGGSAEYAIYAVILSITSNFVITVFLTVICCINISGRAYKRILQLLRIASLLASLNLTIFITKVLRRLEKEHNVYGVVRAHSIMHIFSDDMTFVVLDFLATLMFQFCQVGIVIRLFQRAQEKRIIFFIGVILTITANILWVIPPFANHTTKHRNDWQILRPFVYLFRIAIATSYASIVIYHIWQKKKLWFKFNQMGLLTLLTILVVLLLPGFFLADVSNLWISELGEVFNTTCYVTSTVITWEWLDRLNVLERKEEAQSILGRPIFEEEQQDYRFAKYALRVQNALTRRESQDASTDRHDTSSNSEVCDLQTISRYDPEDQISVGRSIDRMHFNDRGTYKDVALKKLGYARDKILYFTDQIVQKSVGHNNSSSSKNEKTKQRKAMVRKRLGLDKPGIYIYSTKDVVFNSDEDDDENAEDEDDDEYEVGSEGNNNSSATFTSDHIGHI
SIO_010081: YNL294C
subclass of: SO_0000673
so part of: YNL294C
location: complement(78659..80260)
location: region:78659-80260:-1
so has part: feature:78659-80260:-1:exon

NP_014105.1
type: Protein
SIO_000068: ncbiprotein

S000005238
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78659-80260:-1:exon

YNL293W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GYP3
gene: MSB3
locus tag: YNL293W
gene synonym: GYP3
so part of: sequence
location: <80640..>82541
location: region:80640-82541:1
so has part: feature:80640-82541:1:exon
subclass of: SO_0000010

855423
type: Gene
SIO_000068: ncbigene

position:80640:1
position: 80640
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82541:1
position: 82541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80640-82541:1:exon

YNL293W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GYP3
gene: MSB3
locus tag: YNL293W
gene synonym: GYP3
product: Rab GTPase-activating protein MSB3
transcript id: NM_001183131.1
SIO_010081: YNL293W
subclass of: SO_0000673
so part of: YNL293W
location: <80640..>82541
location: region:80640-82541:1
so has part: feature:80640-82541:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80640-82541:1:exon

YNL293W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GYP3
gene: MSB3
locus tag: YNL293W
gene synonym: GYP3
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10679030]
experiment: EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593206]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10559187|PMID:22593206]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:22593206]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22593206]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22593206]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10679030|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22593206|PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0090630 activation of GTPase activity [PMID:22593206]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]
experiment: EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:22593206]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:22593206]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:22593206]
experiment: EXISTENCE:mutant phenotype:GO:0043087 regulation of GTPase activity [PMID:22593206]
experiment: EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:22593206]
experiment: EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:22593206]
experiment: EXISTENCE:physical interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]
note: Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null
codon start: 1
product: Rab GTPase-activating protein MSB3
translation: MQNDQQRFSLQNRTVLAHPYKRLGGAFTVKSPSVPNFHDKMHSDHSSSDSALVNGSFRANDHRSVEPSCLGQASPSEHDGNLSVIDLYGDEVESQRAEGEDDDDNNGDNGNEDLEEVHSDDLDLVPDDDNRQRVELEGAASATSANSNGINNTHFDRYGFKKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDDSPSRFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQVQDLDIIERDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAGLLLLFLDEERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSIDHHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIFQVIQTFPKTLLNPNEIFEKIIFKRRFNLNRLDQDEIDRCRKFVAAQRLKFKTYGELLGNSTSEADLPINDNTDNKGIHITSDAVNEALSSEVYGFKKSLAGVHWNNSIKEKVKQMRKKKDKGD
SIO_010081: YNL293W
subclass of: SO_0000673
so part of: YNL293W
location: 80640..82541
location: region:80640-82541:1
so has part: feature:80640-82541:1:exon

NP_014106.1
type: Protein
SIO_000068: ncbiprotein

S000005237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80640-82541:1:exon

YNL292W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUS4
locus tag: YNL292W
so part of: sequence
location: <82806..>84017
location: region:82806-84017:1
so has part: feature:82806-84017:1:exon
subclass of: SO_0000010

855424
type: Gene
SIO_000068: ncbigene

position:82806:1
position: 82806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:84017:1
position: 84017
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:82806-84017:1:exon

YNL292W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUS4
locus tag: YNL292W
product: pseudouridine synthase PUS4
transcript id: NM_001183130.1
SIO_010081: YNL292W
subclass of: SO_0000673
so part of: YNL292W
location: <82806..>84017
location: region:82806-84017:1
so has part: feature:82806-84017:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:82806-84017:1:exon

YNL292W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUS4
locus tag: YNL292W
EC number: 5.4.99.25
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:9358157]
experiment: EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:9358157]
experiment: EXISTENCE:genetic interaction:GO:0009982 pseudouridine synthase activity [PMID:9358157]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:9358157]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9358157]
experiment: EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136|PMID:25219674]
note: Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
codon start: 1
product: pseudouridine synthase PUS4
translation: MNGIFAIEKPSGITSNQFMLKLQHALTKSQVFSKEIQRATAERKQQYEKQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVIGIGAGTKKLANYLSGTVKVYESEALFGVSTTSGDVEGEILSQNSVKHLNFDDLKTVEEKFVGQLKQTPPIYAALKMDGKPLHEYAREGKPLPRAIEPRQVTIYDLKVFSDSLKRDHDYPLLRPTTEEAVDTVKNLNANMLNDVLYFSKEYTEKHGLDSEVAKVEEPFPLSEQEEQEIQKEGDSYRAPKLHFKANVSSGTYIRSLVSDIGKSMRSSCYMVKLIRLQQQDWSLEKNNVFQLTDFTERDEKVWSKVLEKVLDEGATVDVIEELKKAEKEIPADVKECIVSSDQPGDEATAETIETANAEEHSNTLKRKIEQV
SIO_010081: YNL292W
subclass of: SO_0000673
so part of: YNL292W
location: 82806..84017
location: region:82806-84017:1
so has part: feature:82806-84017:1:exon

NP_014107.1
type: Protein
SIO_000068: ncbiprotein

S000005236
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:82806-84017:1:exon

YNL291C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MID1
locus tag: YNL291C
so part of: sequence
location: complement(<84169..>85815)
location: region:84169-85815:-1
so has part: feature:84169-85815:-1:exon
subclass of: SO_0000010

855425
type: Gene
SIO_000068: ncbigene

position:84169:-1
position: 84169
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85815:-1
position: 85815
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84169-85815:-1:exon

YNL291C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MID1
locus tag: YNL291C
product: Mid1p
transcript id: NM_001183129.1
SIO_010081: YNL291C
subclass of: SO_0000673
so part of: YNL291C
location: complement(<84169..>85815)
location: region:84169-85815:-1
so has part: feature:84169-85815:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84169-85815:-1:exon

YNL291C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MID1
locus tag: YNL291C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14729456]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10958666]
experiment: EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10958666]
experiment: EXISTENCE:direct assay:GO:0015275 stretch-activated, cation-selective, calcium channel activity [PMID:10436155]
experiment: EXISTENCE:mutant phenotype:GO:0005262 calcium channel activity [PMID:12492866|PMID:9343395]
note: Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells
codon start: 1
product: Mid1p
translation: MIVWQALFVVYCLFTTSIHGLFQDFNPFANKNISLKFPSLNRWEKNVMATGQQTIINSDSIYEWTPILSNITAGKKDSFVFTIDAEASGYGFAPTYEVLMFISGNICQMPMNRSDVDLTIYYSFNETVLENPNIGQSAVFQDGYIQALAISPVQSSSSNATSTYSNLYVVAELVNSTTEQPLSSSDASENWEYRLSISENDLVFQWDVRPWVEVLDTDMNSALLSTGNVTADAKVYHNYSIYDPSLYDLYVYSYEDSVQLNQNYNLSLCAVKNGPYLVSSQNTSNATVTSNSTNPLERTDLAIQKKITEYGGSVTEMFYVTGLNASTTYVAYLTKKISNGDGLSSVGGILFSHVYFTTRSTDVCSLIFGLDFCSDVAYSVPTSSFSVGNKTLMAQTYDHIAEALYANFSKALQLISCDADKDARYSPVMTCDDCAEAYRDWVCAVSIPRCTTTSSQYYIHRDKSHNRNDYLNKFIKPLDDYYEILPCIDMCYTLVRNCPSDFQFSCPNDLTTEDLLYQSYNFYMDTDYSTCNYIGNSSLMVIHPLDDT
SIO_010081: YNL291C
subclass of: SO_0000673
so part of: YNL291C
location: complement(84169..85815)
location: region:84169-85815:-1
so has part: feature:84169-85815:-1:exon

NP_014108.1
type: Protein
SIO_000068: ncbiprotein

S000005235
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84169-85815:-1:exon

YNL290W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RFC3
locus tag: YNL290W
so part of: sequence
location: <86218..>87240
location: region:86218-87240:1
so has part: feature:86218-87240:1:exon
subclass of: SO_0000010

855426
type: Gene
SIO_000068: ncbigene

position:86218:1
position: 86218
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:87240:1
position: 87240
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86218-87240:1:exon

YNL290W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RFC3
locus tag: YNL290W
product: replication factor C subunit 3
transcript id: NM_001183128.1
SIO_010081: YNL290W
subclass of: SO_0000673
so part of: YNL290W
location: <86218..>87240
location: region:86218-87240:1
so has part: feature:86218-87240:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:86218-87240:1:exon

YNL290W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RFC3
locus tag: YNL290W
experiment: EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:12604797|PMID:8995429]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:7651383]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8302859]
experiment: EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]
experiment: EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]
experiment: EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]
experiment: EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927]
note: Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: replication factor C subunit 3
translation: MSTSTEKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLADIEYSISKGGNDQIQGSAVIGAIKASFENETVKANV
SIO_010081: YNL290W
subclass of: SO_0000673
so part of: YNL290W
location: 86218..87240
location: region:86218-87240:1
so has part: feature:86218-87240:1:exon

NP_014109.1
type: Protein
SIO_000068: ncbiprotein

S000005234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86218-87240:1:exon

YNL289W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HCS26
gene: PCL1
locus tag: YNL289W
gene synonym: HCS26
so part of: sequence
location: <87897..>88736
location: region:87897-88736:1
so has part: feature:87897-88736:1:exon
subclass of: SO_0000010

855427
type: Gene
SIO_000068: ncbigene

position:87897:1
position: 87897
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:88736:1
position: 88736
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87897-88736:1:exon

YNL289W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HCS26
gene: PCL1
locus tag: YNL289W
gene synonym: HCS26
product: Pcl1p
transcript id: NM_001183127.1
SIO_010081: YNL289W
subclass of: SO_0000673
so part of: YNL289W
location: <87897..>88736
location: region:87897-88736:1
so has part: feature:87897-88736:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87897-88736:1:exon

YNL289W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HCS26
gene: PCL1
locus tag: YNL289W
gene synonym: HCS26
experiment: EXISTENCE:direct assay:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:7973730]
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14688790]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7973730]
experiment: EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:19458192]
experiment: EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:7973730]
experiment: EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]
note: Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
codon start: 1
product: Pcl1p
translation: MCEYSKALHILLKSPVTDDIIKFLTDTTLRVVPSSNYPTPPGSPGEKHLTRLPSLMTFITRLVRYTNVYTPTLLTAACYLNKLKRILPRDATGLPSTIHRIFLACLILSAKFHNDSSPLNKHWARYTDGLFTLEDINLMERQLLQLLNWDLRVNTEDLILDLQPLLEPIKQDLARSSDQRKRINMMMSMNRRTCAGTSPIRSNNRFKLYEKQRNVSIASDLSSATLVDSCNDLRRLKDVTNIANNTVANTNYVRTVEKWNDNVNRQSWDLEQIMSQHGF
SIO_010081: YNL289W
subclass of: SO_0000673
so part of: YNL289W
location: 87897..88736
location: region:87897-88736:1
so has part: feature:87897-88736:1:exon

NP_014110.1
type: Protein
SIO_000068: ncbiprotein

S000005233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87897-88736:1:exon

YNCN0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR40
locus tag: YNCN0001W
so part of: sequence
location: 89210..89306
location: region:89210-89306:1
so has part: feature:89210-89306:1:exon
subclass of: SO_0000578

9164969
type: Gene
SIO_000068: ncbigene

position:89210:1
position: 89210
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:89306:1
position: 89306
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:89210-89306:1:exon

YNCN0001W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR40
locus tag: YNCN0001W
product: SNR40
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:8674114|PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:8674114|PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0000452 snoRNA guided rRNA 2'-O-methylation [PMID:25653162]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U898 and small subunit (SSU) rRNA at position G1271
transcript id: NR_132249.1
SIO_010081: YNCN0001W
subclass of: SO_0000673
so part of: YNCN0001W
location: 89210..89306
location: region:89210-89306:1
so has part: feature:89210-89306:1:exon

S000007304
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:89210-89306:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1407; Autonomously Replicating Sequence
so part of: sequence
location: 89531..89804
location: region:89531-89804:1
so has part: feature:89531-89804:1:region

S000118384
type: SGD
SIO_000068: sgd

position:89531:1
position: 89531
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:89804:1
position: 89804
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:89531-89804:1:region

YNL288W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAF40
locus tag: YNL288W
so part of: sequence
location: <90303..>91424
location: region:90303-91424:1
so has part: feature:90303-91424:1:exon
subclass of: SO_0000010

855428
type: Gene
SIO_000068: ncbigene

position:90303:1
position: 90303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:91424:1
position: 91424
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:90303-91424:1:exon

YNL288W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAF40
locus tag: YNL288W
product: CCR4-NOT core subunit CAF40
transcript id: NM_001183126.1
SIO_010081: YNL288W
subclass of: SO_0000673
so part of: YNL288W
location: <90303..>91424
location: region:90303-91424:1
so has part: feature:90303-91424:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:90303-91424:1:exon

YNL288W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAF40
locus tag: YNL288W
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]
experiment: EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:11733989]
note: Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p
codon start: 1
product: CCR4-NOT core subunit CAF40
translation: MFSAQKPIYGNGAGVNMGGGGPSTNNPGSMSMPGVPTSMGPGMNQQIPSGGPMLMGNTPNNNNSNENGENNGNNGNNGGNDANATRNNPNMVNNRGAVHALDDPNVYHWICQLTYGPQKEQALLELGRKREQFDDLAVVLWSSFGVMTSLLNEIISVYPMLQPQMLSNNLSNRVCNALVLLQCVASHPETKHLFLQAHIPLFLFPFLNTTSRQRTFEYLRLTSLGVIGALVKNDSQDVITFLLRTDIVPLCLRIMESSSELSKTVAIFILQKILLDDVGLQYICATLERFYAVTNVLKDMVEHLTVSTPPGRLLKHIIRCYLRLSDDLEARRLLKIVLPAKLRDNTFTEVLRDDVGSKRCLAQLLLTLNEETS
SIO_010081: YNL288W
subclass of: SO_0000673
so part of: YNL288W
location: 90303..91424
location: region:90303-91424:1
so has part: feature:90303-91424:1:exon

NP_014111.1
type: Protein
SIO_000068: ncbiprotein

S000005232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:90303-91424:1:exon

YNL287W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC21
locus tag: YNL287W
so part of: sequence
location: <91994..>94801
location: region:91994-94801:1
so has part: feature:91994-94801:1:exon
subclass of: SO_0000010

855429
type: Gene
SIO_000068: ncbigene

position:91994:1
position: 91994
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:94801:1
position: 94801
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91994-94801:1:exon

YNL287W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC21
locus tag: YNL287W
product: coatomer subunit gamma
transcript id: NM_001183125.1
SIO_010081: YNL287W
subclass of: SO_0000673
so part of: YNL287W
location: <91994..>94801
location: region:91994-94801:1
so has part: feature:91994-94801:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:91994-94801:1:exon

YNL287W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC21
locus tag: YNL287W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:17101773]
experiment: EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:1461285]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:1461285]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]
note: Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
codon start: 1
product: coatomer subunit gamma
translation: MSAHTYKKFENSTSGDLPDKMTIYQDCMNTFNESPVNSKRCRLLISRLLRLLAQGETFPQNEATALFFSISKLFQHQNDPLRQAVYLAIKELSGISEDVLMATSSIMKDVQNGSDLIKPDAIRSLTYVLDESTAFSAERLLKSAVVSRHPSISSAALCTSYHLLPISEVTIRRFTNETQEAVLDLKQFPNQHGNSEYYPNSTYISQYHALGLLYQLKKTDKMALLKLVRHFSENNSMKNQLAKVELVKIVNDLIYRDPQLFSQFRPLLSDWLSNKFESVQLETAKLITSFATRNSRLVAPELYAAAISALQSLLTVPRVSSRFAALRILNRISMVSPEKIVVCNPELESLINDSNRNISTYAITTLLKTGTSKNISSLISTITNFIHDVSDDFKIIIIDAVRTLSLNFPQEWKSILNFLIDVLKNSEGGFKFKNSIVEALIDIVSFVPQSKELALENLCDFIEDCEFNEILVRILHLLGKEGPSAPNPSLYVRHIYNRVVLENSIIRSAAVVALSKFALTKNDPTLYESIISLLKRIANDKDDEVRDRATIALEFIDSARNKDDVIAQNLIESKYFYDIPSLESKLSSYISSNTDSFATAFDVNQVRKFTEDEMKAINLKRKQEQIFNQKSETTLDTTPEAESVPEKRADANSFAGPNLDDHQEDLLATKYADELLSIEQIKPFGQLVNSSRAISLTEPEAEFVVRGVKHLFKDNVVLQFNITNTLTDIALDNVSVVCTPEISDEAELEELFTLQVDRLLPSEEAACYVAFKKLDEIVMEGFLNNLTFTTKEINPDTNEPFDGDEGFQDEYEIDSIFLNAGDYVKSSFTGNFSATFDELPCEEVAVFNIQEDLSIQEVVDKIILNSSCLPVESTQFAPSDSNSHTLKLFGKSALTGSKVALQIKMIKSSKGLALKVHGKGEDSLLCSDLVNGLMQ
SIO_010081: YNL287W
subclass of: SO_0000673
so part of: YNL287W
location: 91994..94801
location: region:91994-94801:1
so has part: feature:91994-94801:1:exon

NP_014112.1
type: Protein
SIO_000068: ncbiprotein

S000005231
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:91994-94801:1:exon

YNL286W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUS2
locus tag: YNL286W
so part of: sequence
location: <95223..>96080
location: region:95223-96080:1
so has part: feature:95223-96080:1:exon
subclass of: SO_0000010

855430
type: Gene
SIO_000068: ncbigene

position:95223:1
position: 95223
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:96080:1
position: 96080
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:95223-96080:1:exon

YNL286W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUS2
locus tag: YNL286W
product: U2 snRNP complex subunit CUS2
transcript id: NM_001183124.1
SIO_010081: YNL286W
subclass of: SO_0000673
so part of: YNL286W
location: <95223..>96080
location: region:95223-96080:1
so has part: feature:95223-96080:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:95223-96080:1:exon

YNL286W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUS2
locus tag: YNL286W
experiment: EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:26631165|PMID:17403781]
experiment: EXISTENCE:direct assay:GO:0034337 RNA folding [PMID:26631165]
experiment: EXISTENCE:genetic interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]
experiment: EXISTENCE:mutant phenotype:GO:0030620 U2 snRNA binding [PMID:26631165|PMID:9710584]
experiment: EXISTENCE:mutant phenotype:GO:0034337 RNA folding [PMID:26631165]
experiment: EXISTENCE:mutant phenotype:GO:1903241 U2-type prespliceosome assembly [PMID:17403781]
experiment: EXISTENCE:physical interaction:GO:0005686 U2 snRNP [PMID:26631165]
experiment: EXISTENCE:physical interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]
note: Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)
codon start: 1
product: U2 snRNP complex subunit CUS2
translation: MDADELELKGHLKKLKKEELLRRKQLKESNLQKRELEYNNASKNTSIYISGLPTDKTTKEGLTEQFCKYGMIRTNRDGEPLCKLYVNDKGAFKGDALITYSKEESVTLAIEMMNESIFLGKQIRVERAQFQNKEGDNMHGKENDLKEFNGPEPPIKRLKKAKSEGEGEVIDYNDDESLAKADRTVIFANVFNIYKSYTNDDINDIQEDLLEGCEEIGQVDSISVSPNKGEATVVFKNNKVALQCCKIMTGRYFDGQKLLAFISGDENTSSTSDKNEDSEVEDDLI
SIO_010081: YNL286W
subclass of: SO_0000673
so part of: YNL286W
location: 95223..96080
location: region:95223-96080:1
so has part: feature:95223-96080:1:exon

NP_014113.1
type: Protein
SIO_000068: ncbiprotein

S000005230
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:95223-96080:1:exon

YNCN0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF6
locus tag: YNCN0002C
so part of: sequence
location: complement(96241..96312)
location: region:96241-96312:-1
so has part: feature:96241-96312:-1:exon
subclass of: SO_0000663

855432
type: Gene
SIO_000068: ncbigene

position:96241:-1
position: 96241
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:96312:-1
position: 96312
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96241-96312:-1:exon

YNCN0002C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF6
locus tag: YNCN0002C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in glycine codons
SIO_010081: YNCN0002C
subclass of: SO_0000673
so part of: YNCN0002C
location: complement(96241..96312)
location: region:96241-96312:-1
so has part: feature:96241-96312:-1:exon

S000006591
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:96241-96312:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1409; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 96247..96463
location: region:96247-96463:1
so has part: feature:96247-96463:1:region

S000130140
type: SGD
SIO_000068: sgd

position:96247:1
position: 96247
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:96463:1
position: 96463
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96247-96463:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 96451..96609
location: region:96451-96609:1
so has part: feature:96451-96609:1:region

S000007140
type: SGD
SIO_000068: sgd

position:96451:1
position: 96451
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:96609:1
position: 96609
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96451-96609:1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YNLCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YNLCTy1-1
so part of: sequence
location: complement(96610..102523)
location: region:96610-102523:-1
so has part: feature:96610-102523:-1:region

S000007134
type: SGD
SIO_000068: sgd

position:96610:-1
position: 96610
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:102523:-1
position: 102523
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96610-102523:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(96610..96941)
location: region:96610-96941:-1
so has part: feature:96610-96941:-1:region

S000007129
type: SGD
SIO_000068: sgd

position:96941:-1
position: 96941
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96610-96941:-1:region

YNL284C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL284C-B
so part of: sequence
location: complement(<96964..>102232)
location: region:96964-102232:-1
so has part: feature:96964-102232:-1:exon
subclass of: SO_0000010

855433
type: Gene
SIO_000068: ncbigene

position:96964:-1
position: 96964
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:102232:-1
position: 102232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96964-102232:-1:exon

YNL284C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL284C-B
product: gag-pol fusion protein
transcript id: NM_001184415.2
SIO_010081: YNL284C-B
subclass of: SO_0000673
so part of: YNL284C-B
location: complement(<96964..>102232)
location: region:96964-102232:-1
so has part: feature:96964-102232:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:96964-102232:-1:exon

YNL284C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL284C-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYQQQCMMTQNQANPSGWSFYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFAPSQFLPTWVKDILSADYTDIMKILSKSINKMQSDTQEVNDITTLATLHYNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRYIHMTVADLFSDIHSMYEEQQESKRNKSTYRRNPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTSNNSSGPDNDLIRGSTTEPIQLKNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPGINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISKSNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQYNTHESSHTSKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTKLSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNLNSNKRIIEKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YNL284C-B
subclass of: SO_0000673
so part of: YNL284C-B
location: complement(join(96964..100926,100928..102232))
location: region:96964-102232:-1
so has part: feature:100928-102232:-1:exon
so has part: feature:96964-100926:-1:exon

NP_058178.1
type: Protein
SIO_000068: ncbiprotein

S000007387
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100928-102232:-1:exon

position:100928:-1
position: 100928
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:96964-100926:-1:exon

position:100926:-1
position: 100926
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL284C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL284C-A
so part of: sequence
location: complement(<100910..>102232)
location: region:100910-102232:-1
so has part: feature:100910-102232:-1:exon
subclass of: SO_0000010

855434
type: Gene
SIO_000068: ncbigene

position:100910:-1
position: 100910
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100910-102232:-1:exon

YNL284C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL284C-A
product: gag protein
transcript id: NM_001184414.1
SIO_010081: YNL284C-A
subclass of: SO_0000673
so part of: YNL284C-A
location: complement(<100910..>102232)
location: region:100910-102232:-1
so has part: feature:100910-102232:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100910-102232:-1:exon

YNL284C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL284C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYQQQCMMTQNQANPSGWSFYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFAPSQFLPTWVKDILSADYTDIMKILSKSINKMQSDTQEVNDITTLATLHYNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRYIHMTVADLFSDIHSMYEEQQESKRNKSTYRRNPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTSNNSSGPDNDLIRGSTTEPIQLKNKHDLHLRPGTY
SIO_010081: YNL284C-A
subclass of: SO_0000673
so part of: YNL284C-A
location: complement(100910..102232)
location: region:100910-102232:-1
so has part: feature:100910-102232:-1:exon

NP_058179.1
type: Protein
SIO_000068: ncbiprotein

S000007386
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100910-102232:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(102192..102523)
location: region:102192-102523:-1
so has part: feature:102192-102523:-1:region

S000007130
type: SGD
SIO_000068: sgd

position:102192:-1
position: 102192
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102192-102523:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(102632..102700)
location: region:102632-102700:-1
so has part: feature:102632-102700:-1:region

S000007133
type: SGD
SIO_000068: sgd

position:102632:-1
position: 102632
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:102700:-1
position: 102700
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102632-102700:-1:region

YNCN0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0003W
so part of: sequence
location: 102716..102789
location: region:102716-102789:1
so has part: feature:102716-102789:1:exon
subclass of: SO_0000663

855435
type: Gene
SIO_000068: ncbigene

position:102716:1
position: 102716
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:102789:1
position: 102789
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102716-102789:1:exon

YNCN0003W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0003W
product: tRNA-Asn
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0003W
subclass of: SO_0000673
so part of: YNCN0003W
location: 102716..102789
location: region:102716-102789:1
so has part: feature:102716-102789:1:exon

S000006673
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:102716-102789:1:exon

YNL284C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MRPL18
alternative label: uL15m
gene: MRPL10
locus tag: YNL284C
gene synonym: MRPL18; uL15m
so part of: sequence
location: complement(<103134..>104102)
location: region:103134-104102:-1
so has part: feature:103134-104102:-1:exon
subclass of: SO_0000010

855436
type: Gene
SIO_000068: ncbigene

position:103134:-1
position: 103134
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:104102:-1
position: 104102
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:103134-104102:-1:exon

YNL284C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MRPL18
alternative label: uL15m
gene: MRPL10
locus tag: YNL284C
gene synonym: MRPL18; uL15m
product: mitochondrial 54S ribosomal protein YmL10/YmL18
transcript id: NM_001183122.1
SIO_010081: YNL284C
subclass of: SO_0000673
so part of: YNL284C
location: complement(<103134..>104102)
location: region:103134-104102:-1
so has part: feature:103134-104102:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:103134-104102:-1:exon

YNL284C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MRPL18
alternative label: uL15m
gene: MRPL10
locus tag: YNL284C
gene synonym: MRPL18; uL15m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
codon start: 1
product: mitochondrial 54S ribosomal protein YmL10/YmL18
translation: MKAERQTGLRNSFTTVIGRKLINTFVPSMMLTSVAGNDIFFRGLFKSPVLAFQSYRYVSILGQLKPSDGSTKSFKRLGRGPSSGLGKTSGRGQKGQKARGKVKSWFEGGQTPIYKLFPKIGFTNVGAKPLKELNLKRIQWFHDKNRLHLQPGEVLDMNKMRKLGLVTGPIKYGVKILASGKFHYNLPIALEASRASAKAIAAIEKAGGKFTARYYTPLGLRAHLNPQWFLEKRGRVPLQARPTKRRDIDFYSKEEKRGYLVMEKDKLLQDIKEAQNKGSRHFLKQNVKKSSLEIELEELSPEKDWVPVVSNSKVMNIKALDH
SIO_010081: YNL284C
subclass of: SO_0000673
so part of: YNL284C
location: complement(103134..104102)
location: region:103134-104102:-1
so has part: feature:103134-104102:-1:exon

NP_014115.1
type: Protein
SIO_000068: ncbiprotein

S000005228
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:103134-104102:-1:exon

YNCN0004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0004W
so part of: sequence
location: 104805..104877
location: region:104805-104877:1
so has part: feature:104805-104877:1:exon
subclass of: SO_0000663

855437
type: Gene
SIO_000068: ncbigene

position:104805:1
position: 104805
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:104877:1
position: 104877
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:104805-104877:1:exon

YNCN0004W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0004W
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0004W
subclass of: SO_0000673
so part of: YNCN0004W
location: 104805..104877
location: region:104805-104877:1
so has part: feature:104805-104877:1:exon

S000006744
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:104805-104877:1:exon

YNL283C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: STA3
gene: WSC2
locus tag: YNL283C
gene synonym: STA3
so part of: sequence
location: complement(<105184..>106695)
location: region:105184-106695:-1
so has part: feature:105184-106695:-1:exon
subclass of: SO_0000010

855438
type: Gene
SIO_000068: ncbigene

position:105184:-1
position: 105184
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:106695:-1
position: 106695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105184-106695:-1:exon

YNL283C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: STA3
gene: WSC2
locus tag: YNL283C
gene synonym: STA3
product: Wsc2p
transcript id: NM_001183121.1
SIO_010081: YNL283C
subclass of: SO_0000673
so part of: YNL283C
location: complement(<105184..>106695)
location: region:105184-106695:-1
so has part: feature:105184-106695:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:105184-106695:-1:exon

YNL283C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: STA3
gene: WSC2
locus tag: YNL283C
gene synonym: STA3
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20652590|PMID:27337501]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:11545731]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]
experiment: EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10348843]
note: Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication
codon start: 1
product: Wsc2p
translation: MHLDLIHKSFILVWLIYIRAALADQFTYKACYSASDIRKLGLTYKGVYEYQSVSYCQNECPGQAVVALFNGTGCYCGGSVAQLQSLTQVDSSKCDVSCAGWPYQNCGGSSAMNVYINNAASTADSTSSTATSTSTTSSSSTSVSSKTSTKLDTKTSTSSSATHSSSSSSTTSTTTSSSETTTSSSSSSSSSSTSTTSTTSTTSSTTSTSSSPSTTSSSTSASSSSETSSTQATSSSTTSTSSSTSTATVTSTPSSTSIGTSTHYTTRVVTQSVVSQANQQASTIFTTRTSVYATVSSTSSSTSSLLNGKSSSSKSKGLSGGAIAGVVVGVVCGTVALLALALFFFVWKKRRQSSQHVDLEETKQYQPYSLGDADANPVIPPSASSTNWHIPSRNNTALSKNTASTFATYDLPTRAPGGRDSIITGDAHNISKRSHFPSVVYEEPPSIYNGNQRFSATSLPDMMEERQLHIVNPDNVSSNIGSNVSDGDDDYDDAKDSNNSSLR
SIO_010081: YNL283C
subclass of: SO_0000673
so part of: YNL283C
location: complement(105184..106695)
location: region:105184-106695:-1
so has part: feature:105184-106695:-1:exon

NP_014116.1
type: Protein
SIO_000068: ncbiprotein

S000005227
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:105184-106695:-1:exon

YNL282W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POP3
locus tag: YNL282W
so part of: sequence
location: <107687..>108274
location: region:107687-108274:1
so has part: feature:107687-108274:1:exon
subclass of: SO_0000010

855439
type: Gene
SIO_000068: ncbigene

position:107687:1
position: 107687
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108274:1
position: 108274
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:107687-108274:1:exon

YNL282W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POP3
locus tag: YNL282W
product: Pop3p
transcript id: NM_001183120.1
SIO_010081: YNL282W
subclass of: SO_0000673
so part of: YNL282W
location: <107687..>108274
location: region:107687-108274:1
so has part: feature:107687-108274:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:107687-108274:1:exon

YNL282W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POP3
locus tag: YNL282W
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [PMID:14729943]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
experiment: EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9029160]
experiment: EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9029160]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9029160]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9029160]
experiment: EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:9029160]
experiment: EXISTENCE:physical interaction:GO:0005655 nucleolar ribonuclease P complex [PMID:9029160]
note: Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Pop3p
translation: MSGSLKSLDKKIAKRRQVYKPVLDNPFTNEAHMWPRVHDQPLIWQLLQSSIINKLIHIQSKENYPWELYTDFNEIVQYLSGAHGNSDPVCLFVCNKDPDVPLVLLQQIPLLCYMAPMTVKLVQLPKSAMDTFKSVSKYGMLLLRCDDRVDKKFVSQIQKNVDLLQFPWLNAIKYRPTSVKLLKTTVPIVSKKRQK
SIO_010081: YNL282W
subclass of: SO_0000673
so part of: YNL282W
location: 107687..108274
location: region:107687-108274:1
so has part: feature:107687-108274:1:exon

NP_014117.1
type: Protein
SIO_000068: ncbiprotein

S000005226
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:107687-108274:1:exon

YNL281W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HCH1
locus tag: YNL281W
so part of: sequence
location: <108467..>108928
location: region:108467-108928:1
so has part: feature:108467-108928:1:exon
subclass of: SO_0000010

855440
type: Gene
SIO_000068: ncbigene

position:108467:1
position: 108467
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108928:1
position: 108928
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108467-108928:1:exon

YNL281W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HCH1
locus tag: YNL281W
product: Hch1p
transcript id: NM_001183119.1
SIO_010081: YNL281W
subclass of: SO_0000673
so part of: YNL281W
location: <108467..>108928
location: region:108467-108928:1
so has part: feature:108467-108928:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108467-108928:1:exon

YNL281W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HCH1
locus tag: YNL281W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12504007]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0051087 chaperone binding [PMID:12504007]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:12504007]
experiment: EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:12504007]
note: Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
codon start: 1
product: Hch1p
translation: MVVLNPNNWHWVDKNTLPWSKDYLNGKLTSLSTVSSDGKSKIELTQVSSITGDSNVSQRKGKPICYFDLQLSMNVKVTNLDTNKDDEDDDGILADGKLEIPEFMHDESDIPILSQGFDAFDGLVRSEFVPKVVETLLKYQDDLIKEHSKDIQV
SIO_010081: YNL281W
subclass of: SO_0000673
so part of: YNL281W
location: 108467..108928
location: region:108467-108928:1
so has part: feature:108467-108928:1:exon

NP_014118.1
type: Protein
SIO_000068: ncbiprotein

S000005225
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108467-108928:1:exon

YNL280C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG24
locus tag: YNL280C
so part of: sequence
location: complement(<109095..>110411)
location: region:109095-110411:-1
so has part: feature:109095-110411:-1:exon
subclass of: SO_0000010

855441
type: Gene
SIO_000068: ncbigene

position:109095:-1
position: 109095
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110411:-1
position: 110411
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:109095-110411:-1:exon

YNL280C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG24
locus tag: YNL280C
product: delta(14)-sterol reductase
transcript id: NM_001183118.1
SIO_010081: YNL280C
subclass of: SO_0000673
so part of: YNL280C
location: complement(<109095..>110411)
location: region:109095-110411:-1
so has part: feature:109095-110411:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:109095-110411:-1:exon

YNL280C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG24
locus tag: YNL280C
EC number: 1.3.1.70
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0050613 delta14-sterol reductase activity [PMID:32908]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1394506|PMID:1418625|PMID:8125337]
experiment: EXISTENCE:mutant phenotype:GO:0050613 delta14-sterol reductase activity [PMID:1394506|PMID:8125337]
note: C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
codon start: 1
product: delta(14)-sterol reductase
translation: MVSALNPRTTEFEFGGLIGALGISIGLPVFTIILNQMIRPDYFIKGFFQNFDIVELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRDGSKLSYKINGIAMSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKILALGGNSGNIIYDWFIGRELNPRLGPLDIKMFSELRPGMLLWLLINLSCLHHHYLKTGKINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQGKLENLKSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKCRLKYGENWEEYERKVPYKIIPYVY
SIO_010081: YNL280C
subclass of: SO_0000673
so part of: YNL280C
location: complement(109095..110411)
location: region:109095-110411:-1
so has part: feature:109095-110411:-1:exon

NP_014119.1
type: Protein
SIO_000068: ncbiprotein

S000005224
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:109095-110411:-1:exon

YNL279W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRM1
locus tag: YNL279W
so part of: sequence
location: <110917..>112902
location: region:110917-112902:1
so has part: feature:110917-112902:1:exon
subclass of: SO_0000010

855442
type: Gene
SIO_000068: ncbigene

position:110917:1
position: 110917
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:112902:1
position: 112902
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110917-112902:1:exon

YNL279W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRM1
locus tag: YNL279W
product: pheromone-regulated protein PRM1
transcript id: NM_001183117.1
SIO_010081: YNL279W
subclass of: SO_0000673
so part of: YNL279W
location: <110917..>112902
location: region:110917-112902:1
so has part: feature:110917-112902:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:110917-112902:1:exon

YNL279W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRM1
locus tag: YNL279W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11062271]
experiment: EXISTENCE:mutant phenotype:GO:0032220 plasma membrane fusion involved in cytogamy [PMID:11062271|PMID:15590839]
note: Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
codon start: 1
product: pheromone-regulated protein PRM1
translation: MSGFKCYLQLGDRLSQIWLNKYTLVLLLAMLKLLFFSKSIQHAIEVSETYILSNCYSIDSLYSKMTDNTPHYLGIMGNYLIEKGMEETVKATLETLSLIVYASEGLVNFAIDLYLGTYACLIVSAVDGTVDVATNITEKLISLVNDTVSSVANELDTGLNDISKIINKVIKAASKVENFFTGDDDDSNMTSSIKSVNLTISALHNLYIPSSINDKLEELSAKTPDFAQVKNTTKNLISVPFNEVRKNIKAVNASNIIGDTSVLYVPPVSLDNSTGICSSNQSEILAFYSILGHVLKIATVVCITVLICFAVGAMAPVAWNEIKLWRRLCGMRDHYMLSRQDSYTSFSSENTHELKDPFRDPPIQNGQYDVIASYQQCFQTWNTRIAGWMTNLVTFGKSPENIDPKTKQKIEWVVAYMTSERALCVLGIGLLGILVCICQFVMIALLKHKISHSLTSNDGDGVQNLLKSSTAVDIENQMSLWSVQTNKYINTTETNINQEVFGWINTTTLSVNNTVATMISDIDTTLADVFNGTLLYNPMKTVVGCAIENKLYTIEKAMTWIHDKAQLHIPRINGTQIKQALAKQTDNSTIPTASSTSAATENLLENLVNDMREGLLKILRAYHRITLGELTVALVILAVWLVQLPIALVILRLRLRKATFD
SIO_010081: YNL279W
subclass of: SO_0000673
so part of: YNL279W
location: 110917..112902
location: region:110917-112902:1
so has part: feature:110917-112902:1:exon

NP_014120.1
type: Protein
SIO_000068: ncbiprotein

S000005223
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110917-112902:1:exon

YNL278W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAF120
locus tag: YNL278W
so part of: sequence
location: <113271..>116453
location: region:113271-116453:1
so has part: feature:113271-116453:1:exon
subclass of: SO_0000010

855443
type: Gene
SIO_000068: ncbigene

position:113271:1
position: 113271
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:116453:1
position: 116453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113271-116453:1:exon

YNL278W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAF120
locus tag: YNL278W
product: Caf120p
transcript id: NM_001183116.1
SIO_010081: YNL278W
subclass of: SO_0000673
so part of: YNL278W
location: <113271..>116453
location: region:113271-116453:1
so has part: feature:113271-116453:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:113271-116453:1:exon

YNL278W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAF120
locus tag: YNL278W
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:25028499]
note: Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication
codon start: 1
product: Caf120p
translation: MRIFSGDNKVVDSLASNPGLMSPSNFGGDFGSRLKVNVTSKKKLNDSSPTSPMESSPVSPELVPILTLLNAHTHRRYHEGVFLILQDLNNNGTHAARKWKDVYGVLLGTQLALWDAKELAEFTDPSCPVSEKKLKEVASKPTYINLTDATLRTLDNSDNIVMECGKNLTNALVVSTTLKNRYFLQFGNKESFNAWNSAIRLCLYECSSLQEAYTGAFISSRGAKLGDIRILLTNRKYDYKDWVSVRFGAGMPWKRCYAVISQSSSKKKGHFGEINLYENDKKVKKNHAMATIVEAKALYAVYPSSPKLIDSSTIIKVVGSVKFEKKESAQEKDVFIMPEKHQAVPSYDTIIRFLIPAMDTFKLYGRPEKLLSSKNDPHSLLFGLPVLPHIYYLEVEDLLPLTNSVSSLHWSNNEWKEHISDILQRKIAQGYCGCNSTSNITSPLPSPFLGSADLFERADGVLSPKLSYGSKSSSNNSSKNSLPKRERVKLSSSSEQDLNNSDSPSIKRKSPPLVISESPHKVHTPTDASFRTRVTEGSPYAKQRHPKPFASSVNDSPSDRAKSRTVPYNNNDRKATTPEKFERGETSCGKNVDESLEKVRNMKLEIPESNFDKFMTDKNLLSVDSKCSNEKKLSVESDLSAIYEKYSNGPFGHTEGLNGSSDETYLRFQRASVHSESNYNSRKSFTPSDFSNGNEEEHAVLQELNSLTQRINELGMESINSNSDSDRINGSYSQVDFGNNNDEDDMNLFDPDFMAQDQLRAEERDYNKDDRTPLAKVPAAFQSTGLGITPDDDIERQYITEHRSRHEVPKRSPEKPSNPLEIGNPYAKPGTRLNTTHTHSKTDRSITPQRGQPVPSGQQISSYVQPANINSPNKMYGANNSAMGSPRNPKTRAPPGPYNQGWNNRPSPSNIYQRPHPSDTQPQAYHLPGNPYSTGNRPNMQAQYHPQQVPMPILQQPNRPYQPYAMNTHMGSPGGYAGAAPPFQPANVNYNTRPQQPWPTPNSPSAHYRPPPNLNQPQNGSAGYYRPPAPQLQNSQARPQKKDGFSQFMPSATTKNPYAQ
SIO_010081: YNL278W
subclass of: SO_0000673
so part of: YNL278W
location: 113271..116453
location: region:113271-116453:1
so has part: feature:113271-116453:1:exon

NP_014121.1
type: Protein
SIO_000068: ncbiprotein

S000005222
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:113271-116453:1:exon

YNL277W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL277W-A
so part of: sequence
location: <116679..>116867
location: region:116679-116867:1
so has part: feature:116679-116867:1:exon
subclass of: SO_0000010

1466509
type: Gene
SIO_000068: ncbigene

position:116679:1
position: 116679
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:116867:1
position: 116867
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116679-116867:1:exon

YNL277W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL277W-A
product: uncharacterized protein
transcript id: NM_001184664.1
SIO_010081: YNL277W-A
subclass of: SO_0000673
so part of: YNL277W-A
location: <116679..>116867
location: region:116679-116867:1
so has part: feature:116679-116867:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116679-116867:1:exon

YNL277W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL277W-A
codon start: 1
product: uncharacterized protein
translation: MTLAYYGQPVKMCHILPPLRSLPVLVGKKKLKKKKSQTTNNHVIFLFTLFIKLLKTHNRMSL
SIO_010081: YNL277W-A
subclass of: SO_0000673
so part of: YNL277W-A
location: 116679..116867
location: region:116679-116867:1
so has part: feature:116679-116867:1:exon

NP_878151.1
type: Protein
SIO_000068: ncbiprotein

S000028852
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116679-116867:1:exon

YNL277W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MET2
locus tag: YNL277W
so part of: sequence
location: <117349..>118809
location: region:117349-118809:1
so has part: feature:117349-118809:1:exon
subclass of: SO_0000010

855444
type: Gene
SIO_000068: ncbigene

position:117349:1
position: 117349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:118809:1
position: 118809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117349-118809:1:exon

YNL277W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MET2
locus tag: YNL277W
product: homoserine O-acetyltransferase
transcript id: NM_001183115.1
SIO_010081: YNL277W
subclass of: SO_0000673
so part of: YNL277W
location: <117349..>118809
location: region:117349-118809:1
so has part: feature:117349-118809:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:117349-118809:1:exon

YNL277W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MET2
locus tag: YNL277W
EC number: 2.3.1.31
experiment: EXISTENCE:direct assay:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0009092 homoserine metabolic process [PMID:3301801]
experiment: EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]
experiment: EXISTENCE:mutant phenotype:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:6035500]
experiment: EXISTENCE:mutant phenotype:GO:0009092 homoserine metabolic process [PMID:3301801]
note: L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
codon start: 1
product: homoserine O-acetyltransferase
translation: MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW
SIO_010081: YNL277W
subclass of: SO_0000673
so part of: YNL277W
location: 117349..118809
location: region:117349-118809:1
so has part: feature:117349-118809:1:exon

NP_014122.1
type: Protein
SIO_000068: ncbiprotein

S000005221
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117349-118809:1:exon

YNL275W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BOR1
locus tag: YNL275W
so part of: sequence
location: <119268..>120998
location: region:119268-120998:1
so has part: feature:119268-120998:1:exon
subclass of: SO_0000010

855446
type: Gene
SIO_000068: ncbigene

position:119268:1
position: 119268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:120998:1
position: 120998
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:119268-120998:1:exon

YNL275W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BOR1
locus tag: YNL275W
product: Bor1p
transcript id: NM_001183113.1
SIO_010081: YNL275W
subclass of: SO_0000673
so part of: YNL275W
location: <119268..>120998
location: region:119268-120998:1
so has part: feature:119268-120998:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:119268-120998:1:exon

YNL275W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BOR1
locus tag: YNL275W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11401825|PMID:12447444]
experiment: EXISTENCE:direct assay:GO:0046713 borate transport [PMID:17459946]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0080139 borate efflux transmembrane transporter activity [PMID:17459946]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:16565073]
experiment: EXISTENCE:mutant phenotype:GO:0046713 borate transport [PMID:12447444|PMID:16923078|PMID:17459946]
experiment: EXISTENCE:mutant phenotype:GO:0080139 borate efflux transmembrane transporter activity [PMID:12447444|PMID:16923078|PMID:17459946]
note: Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
codon start: 1
product: Bor1p
translation: MSNESTRVTVSRGCTASDECAQALERTNDELDRESSVSESRSDEESHEKLSRRRFPTLGIGIWLDLKDRIPYYKSDWVDAFNYRVIPSIVDTYFNNLLPAIAFAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISIFNYTVYEIIKPLNTSYFGFMFWICMWSMIFHLVLAFTNAVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFSAKSGEKSVQDGFASVVVALVMTAFGLFFKLFHYYPLFSHRIRTFISDYSTALSVLFWSSFTHFGGYLHDVKFKKLPITKAFFPTSKVNRPQNTWLAYEPIPVKDVFIALPFGIFLTILFYFDHNVSSLMAQRHQYKLKKPSSFHYDFALLGLTTCISGVLGIPAPNGLIPQAPLHTETLLVRDSNQKVISCVEQRFTNTFQGLMILGTMTRPLLVCLGEIPQAVLSGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMKVSKKSMLIFLSFSLTGFAGEFAITNTIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQKFTIKNLLLENIRDAKFCDKHED
SIO_010081: YNL275W
subclass of: SO_0000673
so part of: YNL275W
location: 119268..120998
location: region:119268-120998:1
so has part: feature:119268-120998:1:exon

NP_014124.1
type: Protein
SIO_000068: ncbiprotein

S000005219
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:119268-120998:1:exon

YNL274C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GOR1
locus tag: YNL274C
so part of: sequence
location: complement(<121118..>122170)
location: region:121118-122170:-1
so has part: feature:121118-122170:-1:exon
subclass of: SO_0000010

855447
type: Gene
SIO_000068: ncbigene

position:121118:-1
position: 121118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:122170:-1
position: 122170
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:121118-122170:-1:exon

YNL274C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GOR1
locus tag: YNL274C
product: glyoxylate reductase
transcript id: NM_001183112.1
SIO_010081: YNL274C
subclass of: SO_0000673
so part of: YNL274C
location: complement(<121118..>122170)
location: region:121118-122170:-1
so has part: feature:121118-122170:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:121118-122170:-1:exon

YNL274C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GOR1
locus tag: YNL274C
EC number: 1.1.1.26
EC number: 1.1.1.79
EC number: 1.1.1.81
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0009436 glyoxylate catabolic process [PMID:17173333]
experiment: EXISTENCE:mutant phenotype:GO:0047964 glyoxylate reductase (NAD+) activity [PMID:17173333]
note: Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
codon start: 1
product: glyoxylate reductase
translation: MSKKPIVLKLGKDAFGDQAWGELEKIADVITIPESTTREQFLREVKDPQNKLSQVQVITRTARSVKNTGRFDEELALALPSSVVAVCHTGAGYDQIDVEPFKKRHIQVANVPDLVSNATADTHVFLLLGALRNFGIGNRRLIEGNWPEAGPACGSPFGYDPEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPSEEEHGCEYVGFEEFLKRSDIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVIDEQAMTDALRSGKIRSAGLDVFEYEPKISKELLSMSQVLGLPHMGTHSVETRKKMEELVVENAKNVILTGKVLTIVPELQNEDWPNESKPLV
SIO_010081: YNL274C
subclass of: SO_0000673
so part of: YNL274C
location: complement(121118..122170)
location: region:121118-122170:-1
so has part: feature:121118-122170:-1:exon

NP_014125.1
type: Protein
SIO_000068: ncbiprotein

S000005218
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:121118-122170:-1:exon

YNL273W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOF1
locus tag: YNL273W
so part of: sequence
location: <122883..>126599
location: region:122883-126599:1
so has part: feature:122883-126599:1:exon
subclass of: SO_0000010

855448
type: Gene
SIO_000068: ncbigene

position:122883:1
position: 122883
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:126599:1
position: 126599
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122883-126599:1:exon

YNL273W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOF1
locus tag: YNL273W
product: Tof1p
transcript id: NM_001183111.1
SIO_010081: YNL273W
subclass of: SO_0000673
so part of: YNL273W
location: <122883..>126599
location: region:122883-126599:1
so has part: feature:122883-126599:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122883-126599:1:exon

YNL273W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOF1
locus tag: YNL273W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]
experiment: EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]
experiment: EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:12944972]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:16137625]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]
experiment: EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:16103218|PMID:16418273|PMID:17652453]
experiment: EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]
experiment: EXISTENCE:mutant phenotype:GO:0048478 replication fork protection [PMID:16418273|PMID:18632578]
note: Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Tof1p
translation: MSADLQQGTTNAADFSLTVLRARIALLATAIGGPDYTSQIDPPPYKLGDDCLACLKDLKRWFKLVDDQQKRWDVAMAVAEYRILTDDLLPILIDWENKCSLAAKLAKNNPDHEEFRNKAYYDKIALNCLQLLVLMTWPLIVTEQSSSNQITLYGELKKHQLVYKKTILSMESGKVLRAAIRLALDVIKIDRLSRTPRDNMVLKLVLNFFRNVIAIEPGEFTINTKKSMPKKGITSIDTLPPNVSMDDISLNTVISSFHKNKVFGFLLTLTSSLSKEFDQDFINIPLLEIMFYFTKDVNQELLFPRQFETGTHSKVVNKNESSSANNIVTSAGFELSKLLQKEHQMRKNVIKHTSARHSRFGGLLSIQTPDKTRLTVSGSQALVDEKIALQKLDDSKKWNKRIIKKHQSVAAEGLPNSLLNSQTGKAIFFTESNGKHFKEFINNFIDSGFNILLHSVTNYFTTEQDRMVTLEQVEYLLFFAWFVKYQLLRSKIDNSADIKQVSEALKEVTFILVSSLLRSAYDLKNWTVTHAGMIAFNELLNLVSRTKAAQEEDSTDIEFIVSRLFSDERIQLLSNLPKIGSKYSLQFMKSCIELTHSVLKVLEQYSDDKTLVIEGKSRRQKKFNISEGDITKLIEEENVDRDEALDILTSSLRSIEVNFQKVQANYMTEPVIETYINFLERFRELEDDSIKKVFSFFHRVFVQAKEQALLFRFDLIILLREMLSPDGLDRMSRSRKYVSQFSDYFLARLKKRLKKSPAWFVGLLFPPLHNSEVGFYQRYGEYNVLNNESMYAAPASQFKPIPDEEALPPSILLDMKYGVLVSTLLDDGKTELLDQLLKHITHTLDIFKSWLTVNVNAGKETVNPPNEYFTLTGVLNNDPIFKDKDYRALLLLIGYSIPRKINEPCFLPGTVEVSDLTVSCELVKKYLSTPFETPNGLPSSSYLLRVRSEKDSFSHNEQDGWEGDDDYDYNDPYIVPDDQILSKSDAAYFKDLDNNASDKLKGTKFSKGIARSKKKDKRKRRKGEAKTNLPMFGDQDDERPQTVRERHGVFSKEFISDSEDDEDLMNPIFFENETYMRWLLDKNNGQLTEDRYIQFAKFAAERMNNGGVVTGDYTSLFGGSIPSIESIRATESSSFAPDKSLISLASHVASEMSIFDVNNNNNNQLSDDDVNSESRNSLGSSQPSNSQNMFQSEVYSRKESTKRSLEASAADESDEDEEAIRLFGKKSRVVLSQGDSDD
SIO_010081: YNL273W
subclass of: SO_0000673
so part of: YNL273W
location: 122883..126599
location: region:122883-126599:1
so has part: feature:122883-126599:1:exon

NP_014126.1
type: Protein
SIO_000068: ncbiprotein

S000005217
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122883-126599:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1410; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay
so part of: sequence
location: 126599..126805
location: region:126599-126805:1
so has part: feature:126599-126805:1:region

S000130141
type: SGD
SIO_000068: sgd

position:126805:1
position: 126805
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126599-126805:1:region

YNL272C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC2
locus tag: YNL272C
so part of: sequence
location: complement(<126805..>129084)
location: region:126805-129084:-1
so has part: feature:126805-129084:-1:exon
subclass of: SO_0000010

855449
type: Gene
SIO_000068: ncbigene

position:126805:-1
position: 126805
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:129084:-1
position: 129084
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126805-129084:-1:exon

YNL272C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC2
locus tag: YNL272C
product: guanine nucleotide exchange factor SEC2
transcript id: NM_001183110.1
SIO_010081: YNL272C
subclass of: SO_0000673
so part of: YNL272C
location: complement(<126805..>129084)
location: region:126805-129084:-1
so has part: feature:126805-129084:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:126805-129084:-1:exon

YNL272C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC2
locus tag: YNL272C
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9199166]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12045183]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20493815]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:20493815|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:12045183]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]
experiment: EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:20444978]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:12045183]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:20444978]
experiment: EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:29293994]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:29293994]
experiment: EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]
note: Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
codon start: 1
product: guanine nucleotide exchange factor SEC2
translation: MDASEEAKRVSIQVTSLSTQLIESVDKQSHLEEQLNKSLKTIASQKAAIENYNQLKEDYNTLKRELSDRDDEVKRLREDIAKENELRTKAEEEADKLNKEVEDLTASLFDEANNMVADARKEKYAIEILNKRLTEQLREKDTLLDTLTLQLKNLKKVMHSLDNESTVTNNSNRYSTILSDSATSSSTSLNKVPTSYSLASQDIYSGIVYSPSISSIRYDISLYNEFLKFVAALPRCENIKATSTESKLIRRLVNDEIQPILKIDNASGIGWLVKKTLLSLIIDGLVVVEPLSGVNATYQIGYNSSSPAKQATSNMPKMFKFPLDSPPVAVHAACSFCGESRDDIIEHARMYILKTLHKTDDGKEQVTNTYPLCHWCLLKLRQTCEIFAFLRSLKVGAWHLEKLTTQNITKEDLEKFSEVTKHTKRDGRVSSQDKKTKRLSFMAGLGINSSTKNKPKMEIFSSETNAKPGQPTTNIQRAWLQLCKLRCILHWTHIGIWAVDDSISSKIGPLVEDDSDEDQNDAISVRLQDKALWKQDAKRPFSSSSAEESQKSDAFDFESGDMENEITGESSSDESSSDGSSTDNSTADSSSEDESSLADSTTSSADSSSPESIDNGEGDDTVTKDDKSSIKSANNNEENSDCGDKKGRSIIKKKAPQRKIQKKKLLQDLDDLEEQFREESAIDQTEFENAESNVKQNISSKRASSGDENSKKDNNEKTLKTNLTIGDKTQEQIGENSPSSGLHASSSNDDNFDDAQEQQ
SIO_010081: YNL272C
subclass of: SO_0000673
so part of: YNL272C
location: complement(126805..129084)
location: region:126805-129084:-1
so has part: feature:126805-129084:-1:exon

NP_014127.1
type: Protein
SIO_000068: ncbiprotein

S000005216
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:126805-129084:-1:exon

YNL271C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPF3
alternative label: SHE5
gene: BNI1
locus tag: YNL271C
gene synonym: PPF3; SHE5
so part of: sequence
location: complement(<129522..>135383)
location: region:129522-135383:-1
so has part: feature:129522-135383:-1:exon
subclass of: SO_0000010

855450
type: Gene
SIO_000068: ncbigene

position:129522:-1
position: 129522
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135383:-1
position: 135383
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129522-135383:-1:exon

YNL271C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPF3
alternative label: SHE5
gene: BNI1
locus tag: YNL271C
gene synonym: PPF3; SHE5
product: formin BNI1
transcript id: NM_001183109.2
SIO_010081: YNL271C
subclass of: SO_0000673
so part of: YNL271C
location: complement(<129522..>135383)
location: region:129522-135383:-1
so has part: feature:129522-135383:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129522-135383:-1:exon

YNL271C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPF3
alternative label: SHE5
gene: BNI1
locus tag: YNL271C
gene synonym: PPF3; SHE5
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11154270]
experiment: EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638|PMID:9571251]
experiment: EXISTENCE:direct assay:GO:0005522 profilin binding [PMID:15923184|PMID:12134165]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005884 actin filament [PMID:12052901]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11154270]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11154270]
experiment: EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9082982|PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0045010 actin nucleation [PMID:12052901]
experiment: EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:14561409]
experiment: EXISTENCE:direct assay:GO:0070649 formin-nucleated actin cable assembly [PMID:12134165]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:23671312]
experiment: EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]
experiment: EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]
experiment: EXISTENCE:genetic interaction:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:17237521]
experiment: EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:10085293]
experiment: EXISTENCE:mutant phenotype:GO:0005522 profilin binding [PMID:15923184]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10085294|PMID:16166638]
experiment: EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:23671312]
experiment: EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]
experiment: EXISTENCE:mutant phenotype:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:17237521]
experiment: EXISTENCE:physical interaction:GO:0000133 polarisome [PMID:9571251]
note: Formin; polarisome component; nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; functionally redundant with BNR1
codon start: 1
product: formin BNI1
translation: MLKNSGSKHSNSKESHSNSSSGIFQNLKRLANSNATNSNTGSPTYASQQQHSPVGNEVSTSPASSSSFRKLNAPSRSTSTEARPLNKKSTLNTQNLSQYMNGKLSGDVPVSSQHARSHSMQSKYSYSKRNSSQASNKLTRQHTGQSHSASSLLSQGSLTNLSKFTTPDGKIYLEMPSDPYEVEVLFEDIMYKRNIFQSLSEDKQEALMGYSIEKKWLIVKQDLQNELKKMRANTTSSSTASRTSMASDHHPILTANSSLSSPKSVLMTSASSPTSTVYSNSLNHSTTLSSVGTSTSKGKKLVSGSLKKQPSLNNIYRGGAENNTSASTLPGDRTNRPPIHYVQRILADKLTSDEMKDLWVTLRTEQLDWVDAFIDHQGHIAMANVLMNSIYKTAPRENLTKELLEKENSFFKCFRVLSMLSQGLYEFSTHRLMTDTVAEGLFSTKLATRKMATEIFVCMLEKKNKSRFEAVLTSLDKKFRIGQNLHMIQNFKKMPQYFSHLTLESHLKIIQAWLFAVEQTLDGRGKMGSLVGASDEFKNGGGENAILEYCQWTMVFINHLCSCSDNINQRMLLRTKLENCGILRIMNKIKLLDYDKVIDQIELYDNNKLDDFNVKLEANNKAFNVDLHDPLSLLKNLWDICKGTENEKLLVSLVQHLFLSSSKLIEENQNSSKLTKQLKLMDSLVTNVSVASTSDEETNMNMAIQRLYDAMQTDEVARRAILESRALTKKLEEIQAERDSLSEKLSKAEHGLVGQLEDELHERDRILAKNQRVMQQLEAELEELKKKHLLEKHQQEVELRKMLTILNSRPEESFNKNEGTRGMNSSLNSSEKANIQKVLQDGLSRAKKDYKDDSKKFGMTLQPNKRLKMLRMQMENIENEARQLEMTNFAEFEKDRLEPPIHIKKPKVKKMKNKDRKPLVKPQEADVNKLNDLRRALAEIQMESNDISKFNVEERVNELFNEKKSLALKRLKELETKYKGFGIDFNVDEIMDSPKKNTGDVETEEDANYASLDPKTYQKKLDEINRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDDESEEIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEKTFMNRLRKSTVSSAPYLEELTQKVNKVEPYEQNEDEGLDKKSLPENSTASAASAFDKAEKDMRQHVENGKQGRVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLFGESLEKEKKSEDDTVKQETTGDSPAPPPPPPPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPMMPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKAEKFADDLYEKGVLADLEKAFAAREIKSLASKRKEDLQKITFLSRDISQQFGINLHMYSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLEDAKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAVSALQESDNLRNVFNVILAVGNFMNDTSKQAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIVRLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKVLIKTLPVLPEARKKGDLLEDEVKLTIMEFESLMHTYGEDSGDKFAKISFFKKFADFINEYKKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGNEEDEAEDRRAVMDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKDNAPQLLNDLDTEEGSILYSPEAMDPTADTVIHAESPTPLATRGVMNTSEDLPSPSKTSALEDQEEISDRARMLLKELRGSDTPVKQNSILDEHLEKLRARKERSIGEASTGNRLSFK
SIO_010081: YNL271C
subclass of: SO_0000673
so part of: YNL271C
location: complement(129522..135383)
location: region:129522-135383:-1
so has part: feature:129522-135383:-1:exon

NP_014128.2
type: Protein
SIO_000068: ncbiprotein

S000005215
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129522-135383:-1:exon

YNL270C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APL1
gene: ALP1
locus tag: YNL270C
gene synonym: APL1
so part of: sequence
location: complement(<135940..>137661)
location: region:135940-137661:-1
so has part: feature:135940-137661:-1:exon
subclass of: SO_0000010

855451
type: Gene
SIO_000068: ncbigene

position:135940:-1
position: 135940
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:137661:-1
position: 137661
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135940-137661:-1:exon

YNL270C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APL1
gene: ALP1
locus tag: YNL270C
gene synonym: APL1
product: arginine permease ALP1
transcript id: NM_001183108.1
SIO_010081: YNL270C
subclass of: SO_0000673
so part of: YNL270C
location: complement(<135940..>137661)
location: region:135940-137661:-1
so has part: feature:135940-137661:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:135940-137661:-1:exon

YNL270C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APL1
gene: ALP1
locus tag: YNL270C
gene synonym: APL1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]
note: Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
codon start: 1
product: arginine permease ALP1
translation: MDETVNIQMSKEGQYEINSSSIIKEEEFVDEQYSGENVTKAITTERKVEDDAAKETESSPQERREVKRKLKQRHIGMIALGGTIGTGLIIGIGPPLAHAGPVGALISYLFMGTVIYSVTQSLGEMVTFIPVTSSFSVFAQRFLSPALGATNGYMYWLSWCFTFALELSVLGKVIQYWTEAVPLAAWIVIFWCLLTSMNMFPVKYYGEFEFCIASIKVIALLGFIIFSFCVVCGAGQSDGPIGFRYWRNPGAWGPGIISSDKNEGRFLGWVSSLINAAFTYQGTELVGITAGEAANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLDSDGIFVSSSPFMISIENSGTKVLPDIFNAVVLITILSAGNSNVYIGSRVLYSLSKNSLAPRFLSNVTRGGVPYFSVLSTSVFGFLAFLEVSAGSGKAFNWLLNITGVAGFFAWLLISFSHIRFMQAIRKRGISRDDLPYKAQMMPFLAYYASFFIALIVLIQGFTAFAPTFQPIDFVAAYISIFLFLAIWLSFQVWFKCRLLWKLQDIDIDSDRRQIEELVWIEPECKTRWQRVWDVLS
SIO_010081: YNL270C
subclass of: SO_0000673
so part of: YNL270C
location: complement(135940..137661)
location: region:135940-137661:-1
so has part: feature:135940-137661:-1:exon

NP_014129.1
type: Protein
SIO_000068: ncbiprotein

S000005214
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:135940-137661:-1:exon

YNL269W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BSC4
locus tag: YNL269W
so part of: sequence
location: <137699..>138094
location: region:137699-138094:1
so has part: feature:137699-138094:1:exon
subclass of: SO_0000010

855452
type: Gene
SIO_000068: ncbigene

position:137699:1
position: 137699
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:138094:1
position: 138094
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137699-138094:1:exon

YNL269W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BSC4
locus tag: YNL269W
product: Bsc4p
transcript id: NM_001183107.1
SIO_010081: YNL269W
subclass of: SO_0000673
so part of: YNL269W
location: <137699..>138094
location: region:137699-138094:1
so has part: feature:137699-138094:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:137699-138094:1:exon

YNL269W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BSC4
locus tag: YNL269W
note: hypothetical protein; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment
codon start: 1
product: Bsc4p
translation: MSIVLRKSNKKNKNCITSKFYTIHIIKISTPVFRAPIAIGESPYVEWSCLQVVFRKDMVTKKTTFAQLITRLNHFLCQALKRRDSKTYILCRTAVFGAMTPFSPRKSHINNKLPMQPRKKKIVIIYVVRFH
SIO_010081: YNL269W
subclass of: SO_0000673
so part of: YNL269W
location: 137699..138094
location: region:137699-138094:1
so has part: feature:137699-138094:1:exon

NP_014130.1
type: Protein
SIO_000068: ncbiprotein

S000005213
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:137699-138094:1:exon

YNL268W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LYP1
locus tag: YNL268W
so part of: sequence
location: <138550..>140385
location: region:138550-140385:1
so has part: feature:138550-140385:1:exon
subclass of: SO_0000010

855453
type: Gene
SIO_000068: ncbigene

position:138550:1
position: 138550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:140385:1
position: 140385
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138550-140385:1:exon

YNL268W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LYP1
locus tag: YNL268W
product: lysine permease
transcript id: NM_001183106.1
SIO_010081: YNL268W
subclass of: SO_0000673
so part of: YNL268W
location: <138550..>140385
location: region:138550-140385:1
so has part: feature:138550-140385:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138550-140385:1:exon

YNL268W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LYP1
locus tag: YNL268W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:29402931]
note: Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
codon start: 1
product: lysine permease
translation: MGRFSNIITSNKWDEKQNNIGEQSMQELPEDQIEHEMEAIDPSNKTTPYSIDEKQYNTKKKHGSLQGGAIADVNSITNSLTRLQVVSHETDINEDEEEAHYEDKHVKRALKQRHIGMIALGGTIGTGLFVGISTPLSNAGPVGSLIAYIFMGTIVYFVTQSLGEMATFIPVTSSITVFSKRFLSPAFGVSNGYMYWFNWAITYAVEVSVIGQVIEYWTDKVPLAAWIAIFWVIITLMNFFPVKVYGEFEFWVASVKVLAIMGYLIYALIIVCGGSHQGPIGFRYWRNPGAWGPGIISSDKSEGRFLGWVSSLINAAFTYQGTELVGITAGEAANPRKTVPRAINKVVFRIVLFYIMSLFFIGLLVPYNDSRLSASSAVIASSPFVISIQNAGTYALPDIFNAVVLITVVSAANSNVYVGSRVLYSLARTGNAPKQFGYVTRQGVPYLGVVCTAALGLLAFLVVNNNANTAFNWLINISTLAGLCAWLFISLAHIRFMQALKHRGISRDDLPFKAKLMPYGAYYAAFFVTVIIFIQGFQAFCPFKVSEFFTSYISLILLAVVFIGCQIYYKCRFIWKLEDIDIDSDRREIEAIIWEDDEPKNLWEKFWAAVA
SIO_010081: YNL268W
subclass of: SO_0000673
so part of: YNL268W
location: 138550..140385
location: region:138550-140385:1
so has part: feature:138550-140385:1:exon

NP_014131.1
type: Protein
SIO_000068: ncbiprotein

S000005212
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138550-140385:1:exon

YNL267W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PIK120
alternative label: PIK41
gene: PIK1
locus tag: YNL267W
gene synonym: PIK120; PIK41
so part of: sequence
location: <140878..>144078
location: region:140878-144078:1
so has part: feature:140878-144078:1:exon
subclass of: SO_0000010

855454
type: Gene
SIO_000068: ncbigene

position:140878:1
position: 140878
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:144078:1
position: 144078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140878-144078:1:exon

YNL267W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PIK120
alternative label: PIK41
gene: PIK1
locus tag: YNL267W
gene synonym: PIK120; PIK41
product: 1-phosphatidylinositol 4-kinase
transcript id: NM_001183105.1
SIO_010081: YNL267W
subclass of: SO_0000673
so part of: YNL267W
location: <140878..>144078
location: region:140878-144078:1
so has part: feature:140878-144078:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140878-144078:1:exon

YNL267W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PIK120
alternative label: PIK41
gene: PIK1
locus tag: YNL267W
gene synonym: PIK120; PIK41
EC number: 2.7.1.67
experiment: EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:8194527|PMID:8248783]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10587649|PMID:16365163|PMID:8194527]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:10587649|PMID:16365163]
experiment: EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8194527|PMID:8248783]
experiment: EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:10587649]
experiment: EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:10587649]
experiment: EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]
experiment: EXISTENCE:mutant phenotype:GO:2000786 positive regulation of autophagosome assembly [PMID:31125705]
note: Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network
codon start: 1
product: 1-phosphatidylinositol 4-kinase
translation: MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS
SIO_010081: YNL267W
subclass of: SO_0000673
so part of: YNL267W
location: 140878..144078
location: region:140878-144078:1
so has part: feature:140878-144078:1:exon

NP_014132.1
type: Protein
SIO_000068: ncbiprotein

S000005211
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140878-144078:1:exon

YNL265C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IST1
locus tag: YNL265C
so part of: sequence
location: complement(<144280..>145281)
location: region:144280-145281:-1
so has part: feature:144280-145281:-1:exon
subclass of: SO_0000010

855456
type: Gene
SIO_000068: ncbigene

position:144280:-1
position: 144280
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145281:-1
position: 145281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144280-145281:-1:exon

YNL265C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IST1
locus tag: YNL265C
product: Ist1p
transcript id: NM_001183103.1
SIO_010081: YNL265C
subclass of: SO_0000673
so part of: YNL265C
location: complement(join(<144280..145149,145255..>145281))
location: region:144280-145281:-1
so has part: feature:145255-145281:-1:exon
so has part: feature:144280-145149:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145255-145281:-1:exon

position:145255:-1
position: 145255
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:144280-145149:-1:exon

position:145149:-1
position: 145149
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL265C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IST1
locus tag: YNL265C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18032584]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:18032584|PMID:36125415|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:18032582]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032584]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032582]
experiment: EXISTENCE:mutant phenotype:GO:0042030 ATPase inhibitor activity [PMID:36125415]
experiment: EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]
note: Protein involved in recycling of membrane transporters from endosome to plasma membrane; plays a role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
codon start: 1
product: Ist1p
translation: MAPSMIPFTIKLKTCLKMCIQRLRYAQEKQQAIAKQSRRQVAQLLLTNKEQKAHYRVETLIHDDIHIELLEILELYCELLLARVQVINDISTEEQLVKEHMDDGINEAIRSLIYAILFVDEVKELSQLKDLMAWKINVEFVNGVIADHIDVPEKIIKKCSPSVPKEELVDLYLKEIAKTYDVPYSKLENSLSSSSSNISSDFSDPSGDIEDNDEEKPILALDNDDNDNADAKHPITVKKPRQNSENIKNELKIPKDIKKEVIEKKQSEKKTTKRKTKKEQENDELDELKKRFDALRRK
SIO_010081: YNL265C
subclass of: SO_0000673
so part of: YNL265C
location: complement(join(144280..145149,145255..145281))
location: region:144280-145281:-1
so has part: feature:145255-145281:-1:exon
so has part: feature:144280-145149:-1:exon

NP_014134.1
type: Protein
SIO_000068: ncbiprotein

S000005209
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145255-145281:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:144280-145149:-1:exon

YNL264C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISS1
alternative label: SFH4
gene: PDR17
locus tag: YNL264C
gene synonym: ISS1; SFH4
so part of: sequence
location: complement(<145563..>146615)
location: region:145563-146615:-1
so has part: feature:145563-146615:-1:exon
subclass of: SO_0000010

855457
type: Gene
SIO_000068: ncbigene

position:145563:-1
position: 145563
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:146615:-1
position: 146615
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145563-146615:-1:exon

YNL264C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISS1
alternative label: SFH4
gene: PDR17
locus tag: YNL264C
gene synonym: ISS1; SFH4
product: phosphatidylinositol transporter
transcript id: NM_001183102.1
SIO_010081: YNL264C
subclass of: SO_0000673
so part of: YNL264C
location: complement(<145563..>146615)
location: region:145563-146615:-1
so has part: feature:145563-146615:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145563-146615:-1:exon

YNL264C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISS1
alternative label: SFH4
gene: PDR17
locus tag: YNL264C
gene synonym: ISS1; SFH4
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:20016005]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12869188|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10799527|PMID:10848624]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10799527|PMID:10848624]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]
experiment: EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]
experiment: EXISTENCE:genetic interaction:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]
experiment: EXISTENCE:genetic interaction:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:12869188]
experiment: EXISTENCE:mutant phenotype:GO:0006658 phosphatidylserine metabolic process [PMID:10799527]
experiment: EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]
note: Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition
codon start: 1
product: phosphatidylinositol transporter
translation: MGLFSRKRDHTPAVPKEKLIPCDKIFLDPPAKYGNAPLLEPISEDQNEKYRAVLRHFQDDDLKLPENLNDLDNGTHANDRPLSDWEKFWLSRECFLRYLRANKWNTANAIKGLTKTLVWRREIGLTHGKEDKDPLTADKVAVENETGKQVILGFDNAKRPLYYMKNGRQNTESSFRQVQELVYMMETATTVAPQGVEKITVLVDFKSYKEPGIITDKAPPISIARMCLNVMQDHYPERLAKCVLINIPWFAWAFLKMMYPFLDPATKAKAIFDEPFENHIEPSQLDALYNGLLDFKYKHEVYWPDMVKKVDDLRLKRFDRFLKFGGIVGLSEYDTKGQHDELKYPVDMVI
SIO_010081: YNL264C
subclass of: SO_0000673
so part of: YNL264C
location: complement(145563..146615)
location: region:145563-146615:-1
so has part: feature:145563-146615:-1:exon

NP_014135.1
type: Protein
SIO_000068: ncbiprotein

S000005208
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145563-146615:-1:exon

YNL263C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YIF1
locus tag: YNL263C
so part of: sequence
location: complement(<146896..>147840)
location: region:146896-147840:-1
so has part: feature:146896-147840:-1:exon
subclass of: SO_0000010

855458
type: Gene
SIO_000068: ncbigene

position:146896:-1
position: 146896
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147840:-1
position: 147840
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146896-147840:-1:exon

YNL263C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YIF1
locus tag: YNL263C
product: protein transporter YIF1
transcript id: NM_001183101.1
SIO_010081: YNL263C
subclass of: SO_0000673
so part of: YNL263C
location: complement(<146896..>147840)
location: region:146896-147840:-1
so has part: feature:146896-147840:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:146896-147840:-1:exon

YNL263C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YIF1
locus tag: YNL263C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10970842]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10970842]
experiment: EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]
note: Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
codon start: 1
product: protein transporter YIF1
translation: MSYNPYAYATSEQNGVNDRFSHTPQQQRPMQIPRNTPVNGQGNANMNANVNGSGGGFPFQDPRGSMAFQLGQSAFSNFIGQDNFNQFQETVNKATANAAGSQQISTYFQVSTRYVINKLKLILVPFLNGTKNWQRIMDSGNFLPPRDDVNSPDMYMPIMGLVTYILIWNTQQGLKGSFNPEDLYYKLSSTLAFVCLDLLILKLGLYLLIDSKIPSFSLVELLCYVGYKFVPLILAQLLTNVTMPFNLNILIKFYLFIAFGVFLLRSVKFNLLSRSGAEDDDIHVSISKSTVKKCNYFLFVYGFIWQNVLMWLMG
SIO_010081: YNL263C
subclass of: SO_0000673
so part of: YNL263C
location: complement(146896..147840)
location: region:146896-147840:-1
so has part: feature:146896-147840:-1:exon

NP_014136.1
type: Protein
SIO_000068: ncbiprotein

S000005207
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:146896-147840:-1:exon

YNL262W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DUN2
gene: POL2
locus tag: YNL262W
gene synonym: DUN2
so part of: sequence
location: <148212..>154880
location: region:148212-154880:1
so has part: feature:148212-154880:1:exon
subclass of: SO_0000010

855459
type: Gene
SIO_000068: ncbigene

position:148212:1
position: 148212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:154880:1
position: 154880
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148212-154880:1:exon

YNL262W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DUN2
gene: POL2
locus tag: YNL262W
gene synonym: DUN2
product: DNA polymerase epsilon catalytic subunit
transcript id: NM_001183100.1
SIO_010081: YNL262W
subclass of: SO_0000673
so part of: YNL262W
location: <148212..>154880
location: region:148212-154880:1
so has part: feature:148212-154880:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148212-154880:1:exon

YNL262W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DUN2
gene: POL2
locus tag: YNL262W
gene synonym: DUN2
EC number: 2.7.7.7
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:16369485]
experiment: EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893|PMID:18851837]
experiment: EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:14622139|PMID:16369485]
experiment: EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:12571237|PMID:2406268]
experiment: EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:31765407]
experiment: EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]
experiment: EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]
experiment: EXISTENCE:genetic interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837|PMID:8895664]
experiment: EXISTENCE:mutant phenotype:GO:0003887 DNA-directed DNA polymerase activity [PMID:1537345]
experiment: EXISTENCE:mutant phenotype:GO:0006272 leading strand elongation [PMID:17615360]
experiment: EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:8423775]
experiment: EXISTENCE:mutant phenotype:GO:0006297 nucleotide-excision repair, DNA gap filling [PMID:11452038]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:12665575]
experiment: EXISTENCE:mutant phenotype:GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity [PMID:1658784]
experiment: EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:8895664]
experiment: EXISTENCE:mutant phenotype:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:9792727]
experiment: EXISTENCE:mutant phenotype:GO:0035822 gene conversion [PMID:20595613]
experiment: EXISTENCE:mutant phenotype:GO:0045004 DNA replication proofreading [PMID:1658784|PMID:21124948]
experiment: EXISTENCE:physical interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837]
note: Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
codon start: 1
product: DNA polymerase epsilon catalytic subunit
translation: MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATLVSQETLSSGSNGGGNSNDGERVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIATKEDKFKQTSLTKFFSKTKNVPTMGKIKDIEDLFEPTVEEDNAKIKIARTTKKKAVSKRKRNQLTNEEDPLVLPSEIPSMDEDYVGWLNYQKIKWKIQARDRKRRDQLFGNTNSSRERSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMDLGASVTFRSKAMGALGKGIQQGFEMKDLSMAENERYLSGFSMDIGYLLHFPTSIGYEFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNEVLLPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDLVNNNMGIDDKDAVINSPSEFVHDAFSNDALNVLRGMLKEWWDEALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNSGTQRPTQIVNVKKQDKEDSVENSL…
SIO_010081: YNL262W
subclass of: SO_0000673
so part of: YNL262W
location: 148212..154880
location: region:148212-154880:1
so has part: feature:148212-154880:1:exon

NP_014137.1
type: Protein
SIO_000068: ncbiprotein

S000005206
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148212-154880:1:exon

YNL261W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ORC5
locus tag: YNL261W
so part of: sequence
location: <155100..>156539
location: region:155100-156539:1
so has part: feature:155100-156539:1:exon
subclass of: SO_0000010

855460
type: Gene
SIO_000068: ncbigene

position:155100:1
position: 155100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:156539:1
position: 156539
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:155100-156539:1:exon

YNL261W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ORC5
locus tag: YNL261W
product: origin recognition complex subunit 5
transcript id: NM_001183099.1
SIO_010081: YNL261W
subclass of: SO_0000673
so part of: YNL261W
location: <155100..>156539
location: region:155100-156539:1
so has part: feature:155100-156539:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:155100-156539:1:exon

YNL261W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ORC5
locus tag: YNL261W
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
experiment: EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:7579692]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9038340]
experiment: EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188|PMID:7579692]
note: Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
codon start: 1
product: origin recognition complex subunit 5
translation: MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYFNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIKLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTILVMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFIHLIVQAFHSYTGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLSENGQGESAITTNRDDLENSQTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIEVFQNLSELHTLKLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIHE
SIO_010081: YNL261W
subclass of: SO_0000673
so part of: YNL261W
location: 155100..156539
location: region:155100-156539:1
so has part: feature:155100-156539:1:exon

NP_014138.1
type: Protein
SIO_000068: ncbiprotein

S000005205
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:155100-156539:1:exon

YNL260C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LTO1
locus tag: YNL260C
so part of: sequence
location: complement(<156859..>157347)
location: region:156859-157347:-1
so has part: feature:156859-157347:-1:exon
subclass of: SO_0000010

855461
type: Gene
SIO_000068: ncbigene

position:156859:-1
position: 156859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157347:-1
position: 157347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156859-157347:-1:exon

YNL260C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LTO1
locus tag: YNL260C
product: ribosome biosynthesis protein LTO1
transcript id: NM_001183098.2
SIO_010081: YNL260C
subclass of: SO_0000673
so part of: YNL260C
location: complement(<156859..>157347)
location: region:156859-157347:-1
so has part: feature:156859-157347:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:156859-157347:-1:exon

YNL260C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LTO1
locus tag: YNL260C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23318452|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]
experiment: EXISTENCE:direct assay:GO:0062092 Yae1-Lto1 complex [PMID:26182403]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]
experiment: EXISTENCE:mutant phenotype:GO:0062092 Yae1-Lto1 complex [PMID:26182403]
experiment: EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:26182403]
note: Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion
codon start: 1
product: ribosome biosynthesis protein LTO1
translation: MDFDNLLNLEEQYYQEGFLEGQNENIKQSFLEGKQYGLQVGFQRFTLLGQMEGLCDVIESYGLHSPTLEKNIHTIRTLMKGLKMNNDDESVMEFERVLIKLKNKFRTILITLHRLVKDKRTPTVTFEVFEDVSRAIAGEIRGFVENEDIAKNKTKQNQAQSW
SIO_010081: YNL260C
subclass of: SO_0000673
so part of: YNL260C
location: complement(156859..157347)
location: region:156859-157347:-1
so has part: feature:156859-157347:-1:exon

NP_014139.2
type: Protein
SIO_000068: ncbiprotein

S000005204
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:156859-157347:-1:exon

YNL259C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATX1
locus tag: YNL259C
so part of: sequence
location: complement(<157644..>157865)
location: region:157644-157865:-1
so has part: feature:157644-157865:-1:exon
subclass of: SO_0000010

855462
type: Gene
SIO_000068: ncbigene

position:157644:-1
position: 157644
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157865:-1
position: 157865
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:157644-157865:-1:exon

YNL259C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATX1
locus tag: YNL259C
product: copper metallochaperone ATX1
transcript id: NM_001183097.1
SIO_010081: YNL259C
subclass of: SO_0000673
so part of: YNL259C
location: complement(<157644..>157865)
location: region:157644-157865:-1
so has part: feature:157644-157865:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:157644-157865:-1:exon

YNL259C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATX1
locus tag: YNL259C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9083054]
experiment: EXISTENCE:direct assay:GO:0016531 copper chaperone activity [PMID:17961510|PMID:9346482]
experiment: EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:9083054]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:9083054]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:7731983]
note: Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1
codon start: 1
product: copper metallochaperone ATX1
translation: MAEIKHYQFNVVMTCSGCSGAVNKVLTKLEPDVSKIDISLEKQLVDVYTTLPYDFILEKIKKTGKEVRSGKQL
SIO_010081: YNL259C
subclass of: SO_0000673
so part of: YNL259C
location: complement(157644..157865)
location: region:157644-157865:-1
so has part: feature:157644-157865:-1:exon

NP_014140.1
type: Protein
SIO_000068: ncbiprotein

S000005203
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:157644-157865:-1:exon

YNL258C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RNS1
gene: DSL1
locus tag: YNL258C
gene synonym: RNS1
so part of: sequence
location: complement(<158109..>160373)
location: region:158109-160373:-1
so has part: feature:158109-160373:-1:exon
subclass of: SO_0000010

855463
type: Gene
SIO_000068: ncbigene

position:158109:-1
position: 158109
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:160373:-1
position: 160373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:158109-160373:-1:exon

YNL258C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RNS1
gene: DSL1
locus tag: YNL258C
gene synonym: RNS1
product: Dsl1p
transcript id: NM_001183096.1
SIO_010081: YNL258C
subclass of: SO_0000673
so part of: YNL258C
location: complement(<158109..>160373)
location: region:158109-160373:-1
so has part: feature:158109-160373:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:158109-160373:-1:exon

YNL258C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RNS1
gene: DSL1
locus tag: YNL258C
gene synonym: RNS1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15942868]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:19346454]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11739780]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11493604]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11739780|PMID:11493604]
experiment: EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:19346454]
experiment: EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]
note: Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene
codon start: 1
product: Dsl1p
translation: MESLFPNKGEIIRELLKDPLILKNDSKRSNGSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMRNNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITENSIQFTPTVEWGKDKVHIEYDTFMDFVAQQYFPKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSSSHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPLKNLVSVINNKLTRLVAKSEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIRSIFEDPKKSWQNLEVVELTTSNTNTMSEKIGKNDSDVQNEKELHNAVSKDDDWNWEVEDDDADAWGDEIDVNIDDEEEKTNQEKEKEPEEEENAWDEAWAIDENIDDASLENGKEHLKAHDVGSLDKDHIEVTQLPKLFLAISQNFKSSFADSHVDEQYFAYKYNLLQTSYMAMCTANFSHNWCQLYVDMRYLIERDEKLYRIKELTRNLLETKLNMKYRIVCQLIRHQLTEFRENERNPSWDATIEKLLPYILKEIVRPLQKIRGEEGSRYLLSFLNFLYNDCVTKEILKWQIISEVNSENLGELVSLLVNNTDIQLLAKEPSYKKMREKFATMGKFLPLHLKEIMEMFYNGDFYLFATDELIQWIELLFADTPLRRNAIDDIYEIRGTALDD
SIO_010081: YNL258C
subclass of: SO_0000673
so part of: YNL258C
location: complement(158109..160373)
location: region:158109-160373:-1
so has part: feature:158109-160373:-1:exon

NP_014141.1
type: Protein
SIO_000068: ncbiprotein

S000005202
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:158109-160373:-1:exon

YNL257C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LAM3
gene: SIP3
locus tag: YNL257C
gene synonym: LAM3
so part of: sequence
location: complement(<160631..>164320)
location: region:160631-164320:-1
so has part: feature:160631-164320:-1:exon
subclass of: SO_0000010

855464
type: Gene
SIO_000068: ncbigene

position:160631:-1
position: 160631
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164320:-1
position: 164320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160631-164320:-1:exon

YNL257C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LAM3
gene: SIP3
locus tag: YNL257C
gene synonym: LAM3
product: Sip3p
transcript id: NM_001183095.1
SIO_010081: YNL257C
subclass of: SO_0000673
so part of: YNL257C
location: complement(<160631..>164320)
location: region:160631-164320:-1
so has part: feature:160631-164320:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160631-164320:-1:exon

YNL257C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LAM3
gene: SIP3
locus tag: YNL257C
gene synonym: LAM3
experiment: EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:8127709]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8127709]
experiment: EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]
note: Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p
codon start: 1
product: Sip3p
translation: MSVHGRDPKKRQLRLISVAFKEASIDSPSFRASVNFFQTRVDALEDWIEKTVDFFDQKYKVSFEDFRRAKETLLSQLLPPPALLSNGFVSNQSFTPRLIDSFNKDYYDFSMKLLQIVKGDDSSHSTALLELMTTAIEPYRNVRKNFDFYQGKYDSMLASYQAIRISKTSLEPSSIKSDALQLFEVQKNYLKASLDLISAISAVKLSLDKFILESMKVLKSRSIFITKDSGRKIDLSPCINEYLDNYAIWVENSIEGSKVLDSDISNAKKQAYRYTLKRITPSSDTSDYNIRSIHSSKLLSKDTQVPPKSPEKSGWLYMKTQVGKPTREIWVRRWCFLKNAVFGMFLLSPSKTYVEETDKFGVFLTNVRYDPEEDRKFCFEVKIFGNKVTEAHDNMSKDITLVFQTSNYLDLKSWLIAFEATKKYVMSIQHDSLEYELAFKRFSPKFFEFASSTTTSIDQLITTFDKETESLYETLNCSISEYDILTLGEEKVFQFQMPTTPISTKMTQLAILSNFLTKGSWFPNAVLANIWGTTDWSEYTILPGKGKKPSSLLTIDGKRLPIRNSTIYPQYYSNELKVLDLQFKSLVFSPDQRLEKLPEELLLFKFEALWCPNKKQKFSATCFCTKDYIYCYMNSMEFICLTKISLSEIVSVEADRSSKKTLKLYDASGLQMKAIVLFSDYKLIASKLQYLLENKAIKNPNSNEEILVKFEQMEKESQEKKQEELYKIEQENSFDRKATSVSKIIKSRVTFWEMSDDASTLLNRLKKLQTEYSITYNHEYEISSKGLAHILFGDKSNAFPKCLFLARKDGEEHGKRFWYKNKDINGKSQLVRKIPFRLDMTGNFLNTGKYHRDKESKMIFATQRIVKIVDNKYYEVDLDPFFVKVPFCHLLKLSIKFVITESYDVDNHLEIKLNMTASSSSLHVLYKLEYIDSRTGKTIEKLSLAEIICQTWALKFAHSEFLLIRRVLRYYLEKIGKHGKVIKAIKLCGILGVLSNKSEEPATEKNGNSKESESMQYDIRYSCTILFLVFIKLMVYRVTNLTFVFFRILIGILLLCAEKFSRINRMMVVGLLASIMINILLSEKASVPYWSIKRAEKLFHDRLGSDKFTMQRAIYISDSDLLSSQLSVPSNNPIFEKFSEDNFNKDYQYSETRKQLAMRRNELLIELRILQDMEKQLVHDDYEKFLLEEVNKCSMVSIEMTDLWFNDTQLQNYCSICNEELEKLRPPIT
SIO_010081: YNL257C
subclass of: SO_0000673
so part of: YNL257C
location: complement(160631..164320)
location: region:160631-164320:-1
so has part: feature:160631-164320:-1:exon

NP_014142.1
type: Protein
SIO_000068: ncbiprotein

S000005201
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160631-164320:-1:exon

YNL256W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FOL1
locus tag: YNL256W
so part of: sequence
location: <164623..>167097
location: region:164623-167097:1
so has part: feature:164623-167097:1:exon
subclass of: SO_0000010

855465
type: Gene
SIO_000068: ncbigene

position:164623:1
position: 164623
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167097:1
position: 167097
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164623-167097:1:exon

YNL256W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FOL1
locus tag: YNL256W
product: trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1
transcript id: NM_001183094.1
SIO_010081: YNL256W
subclass of: SO_0000673
so part of: YNL256W
location: <164623..>167097
location: region:164623-167097:1
so has part: feature:164623-167097:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164623-167097:1:exon

YNL256W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FOL1
locus tag: YNL256W
EC number: 2.5.1.15
EC number: 2.7.6.3
EC number: 4.1.2.25
experiment: EXISTENCE:direct assay:GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [PMID:15169867]
experiment: EXISTENCE:direct assay:GO:0004150 dihydroneopterin aldolase activity [PMID:15169867]
experiment: EXISTENCE:direct assay:GO:0004156 dihydropteroate synthase activity [PMID:15169867]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8813764]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15169867]
experiment: EXISTENCE:mutant phenotype:GO:0004156 dihydropteroate synthase activity [PMID:11731153]
experiment: EXISTENCE:mutant phenotype:GO:0046654 tetrahydrofolate biosynthetic process [PMID:11731153|PMID:15169867]
note: Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
codon start: 1
product: trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1
translation: MSKLFSTVNSARHSVPLGGMRDYVHIKKLEMNTVLGPDSWNQLMPQKCLLSLDMGTDFSKSAATDDLKYSLNYAVISRDLTNFVSKKKNWGSVSNLAKSVSQFVMDKYSGVECLNLEVQADTTHIRSDHISCIIQQERGNPESQEFDVVRISELKMLTLIGVFTFERLKKQYVTLDIKLPWPKKAELPPPVQSIIDNVVKFVEESNFKTVEALVESVSAVIAHNEYFQKFPDSPLVVKVLKLNAITATEGVGVSCIREPREIAMVNIPYLSSIHESSDIKFQLSSSQNTPIEGKNTWKRAFLAFGSNIGDRFKHIQMALQLLSREKTVKLRNISSIFESEPMYFKDQTPFMNGCVEVETLLTPSELLKLCKKIEYEELQRVKHFDNGPRTIDLDIVMFLNSAGEDIIVNEPDLNIPHPRMLERTFVLEPLCELISPVHLHPVTAEPIVDHLKQLYDKQHDEDTLWKLVPLPYRSGVEPRFLKFKTATKLDEFTGETNRITVSPTYIMAIFNATPDSFSDGGEHFADIESQLNDIIKLCKDALYLHESVIIDVGGCSTRPNSIQASEEEEIRRSIPLIKAIRESTELPQDKVILSIDTYRSNVAKEAIKVGVDIINDISGGLFDSNMFAVIAENPEICYILSHTRGDISTMNRLAHYENFALGDSIQQEFVHNTDIQQLDDLKDKTVLIRNVGQEIGERYIKAIDNGVKRWQILIDPGLGFAKTWKQNLQIIRHIPILKNYSFTMNSNNSQVYVNLRNMPVLLGPSRKKFIGHITKDVDAKQRDFATGAVVASCIGFGSDMVRVHDVKNCSKSIKLADAIYKGLE
SIO_010081: YNL256W
subclass of: SO_0000673
so part of: YNL256W
location: 164623..167097
location: region:164623-167097:1
so has part: feature:164623-167097:1:exon

NP_014143.2
type: Protein
SIO_000068: ncbiprotein

S000005200
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164623-167097:1:exon

YNL255C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIS2
locus tag: YNL255C
so part of: sequence
location: complement(<167329..>167790)
location: region:167329-167790:-1
so has part: feature:167329-167790:-1:exon
subclass of: SO_0000010

855466
type: Gene
SIO_000068: ncbigene

position:167329:-1
position: 167329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167790:-1
position: 167790
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167329-167790:-1:exon

YNL255C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIS2
locus tag: YNL255C
product: mRNA-binding translational activator GIS2
transcript id: NM_001183093.1
SIO_010081: YNL255C
subclass of: SO_0000673
so part of: YNL255C
location: complement(<167329..>167790)
location: region:167329-167790:-1
so has part: feature:167329-167790:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167329-167790:-1:exon

YNL255C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIS2
locus tag: YNL255C
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640|PMID:23285195]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21232131]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764|PMID:21232131|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23285195]
experiment: EXISTENCE:direct assay:GO:0042788 polysomal ribosome [PMID:21277287]
experiment: EXISTENCE:direct assay:GO:0045182 translation regulator activity [PMID:21277287]
experiment: EXISTENCE:direct assay:GO:2000767 positive regulation of cytoplasmic translation [PMID:21277287]
note: Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
codon start: 1
product: mRNA-binding translational activator GIS2
translation: MSQKACYVCGKIGHLAEDCDSERLCYNCNKPGHVQTDCTMPRTVEFKQCYNCGETGHVRSECTVQRCFNCNQTGHISRECPEPKKTSRFSKVSCYKCGGPNHMAKDCMKEDGISGLKCYTCGQAGHMSRDCQNDRLCYNCNETGHISKDCPKA
SIO_010081: YNL255C
subclass of: SO_0000673
so part of: YNL255C
location: complement(167329..167790)
location: region:167329-167790:-1
so has part: feature:167329-167790:-1:exon

NP_014144.1
type: Protein
SIO_000068: ncbiprotein

S000005199
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167329-167790:-1:exon

YNL254C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTC4
locus tag: YNL254C
so part of: sequence
location: complement(<168043..>169248)
location: region:168043-169248:-1
so has part: feature:168043-169248:-1:exon
subclass of: SO_0000010

855467
type: Gene
SIO_000068: ncbigene

position:168043:-1
position: 168043
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169248:-1
position: 169248
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168043-169248:-1:exon

YNL254C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTC4
locus tag: YNL254C
product: Rtc4p
transcript id: NM_001183092.1
SIO_010081: YNL254C
subclass of: SO_0000673
so part of: YNL254C
location: complement(<168043..>169248)
location: region:168043-169248:-1
so has part: feature:168043-169248:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:168043-169248:-1:exon

YNL254C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTC4
locus tag: YNL254C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
codon start: 1
product: Rtc4p
translation: MVGPGLGINRVRRKGVYSTKKGSGDNLLLMKRQGKHDIHDRESDDLSGHDAFSPSKKRGKIDSITEDEIEVKKLSTVATFDKLSRSFPNSEVQAAKNAALRGKEKEEEKVVSIPLIQNLKNEDIESIKCRNNNLLDGKKLLLEAELSAVEDNQIFSSSFPEDKKLSLQSCLSSKEQIIKKLQVREEYMSKFKLPPMLFSDELLTEVEPFMPIVMDILEGKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTHNQPATLKWWGITDFCNYVLAPETLTSFCIYQLNLSNKSCSSKTPNKHPKQQLNEKEYYYDPELRMLAYDLLEDTVEYGIIVADSDPIEQWEAAIEEDRLRELKLDVHNYSSRRWRLDTHD
SIO_010081: YNL254C
subclass of: SO_0000673
so part of: YNL254C
location: complement(168043..169248)
location: region:168043-169248:-1
so has part: feature:168043-169248:-1:exon

NP_014145.1
type: Protein
SIO_000068: ncbiprotein

S000005198
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:168043-169248:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1411; ARS activated in late S phase
so part of: sequence
location: 169675..169753
location: region:169675-169753:1
so has part: feature:169675-169753:1:region

S000077373
type: SGD
SIO_000068: sgd

position:169675:1
position: 169675
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:169753:1
position: 169753
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169675-169753:1:region

YNL253W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TEX1
locus tag: YNL253W
so part of: sequence
location: <170018..>171286
location: region:170018-171286:1
so has part: feature:170018-171286:1:exon
subclass of: SO_0000010

855468
type: Gene
SIO_000068: ncbigene

position:170018:1
position: 170018
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171286:1
position: 171286
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:170018-171286:1:exon

YNL253W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TEX1
locus tag: YNL253W
product: Tex1p
transcript id: NM_001183091.1
SIO_010081: YNL253W
subclass of: SO_0000673
so part of: YNL253W
location: <170018..>171286
location: region:170018-171286:1
so has part: feature:170018-171286:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:170018-171286:1:exon

YNL253W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TEX1
locus tag: YNL253W
experiment: EXISTENCE:curator inference:GO:0006406 mRNA export from nucleus [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
note: Protein involved in mRNA export; component of the transcription export (TREX) complex
codon start: 1
product: Tex1p
translation: MSTIGAVDILNQKTITSEVAASVTSKYLQSTFSKGNTSHIEDKRFIHVSSRSHSRFTSTPITPNEILSLKFHVSGSSMAYSRMDGSLTVWFIKDASFDKSVEVYIPDCCGSDKLATDLSWNPTSLNQIAVVSNSSEISLLLINEKSLTASKLRTLSLGSKTKVNTCLYDPLGNWLLAATKSEKIYLFDVKKDHSSVCSLNISDISQEDNDVVYSLAWSNGGSHIFIGFKSGYLAILKAKHGILEVCTKIKAHTGPITEIKMDPWGRNFITGSIDGNCYVWNMKSLCCELIINDLNSAVTTLDVCHLGKILGICTEDEMVYFYDLNSGNLLHSKSLANYKTDPVLKFYPDKSWYIMSGKNDTLSNHFVKNEKNLITYWKDMFDNTMIEKRRKNNGGGNNHNKRTSKNTDRIGKDRPSRFNSKK
SIO_010081: YNL253W
subclass of: SO_0000673
so part of: YNL253W
location: 170018..171286
location: region:170018-171286:1
so has part: feature:170018-171286:1:exon

NP_014146.1
type: Protein
SIO_000068: ncbiprotein

S000005197
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:170018-171286:1:exon

YNL252C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL46
alternative label: MRPL30
gene: MRPL17
locus tag: YNL252C
gene synonym: mL46; MRPL30
so part of: sequence
location: complement(<171441..>172286)
location: region:171441-172286:-1
so has part: feature:171441-172286:-1:exon
subclass of: SO_0000010

855469
type: Gene
SIO_000068: ncbigene

position:171441:-1
position: 171441
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:172286:-1
position: 172286
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171441-172286:-1:exon

YNL252C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL46
alternative label: MRPL30
gene: MRPL17
locus tag: YNL252C
gene synonym: mL46; MRPL30
product: mitochondrial 54S ribosomal protein YmL17/YmL30
transcript id: NM_001183090.1
SIO_010081: YNL252C
subclass of: SO_0000673
so part of: YNL252C
location: complement(<171441..>172286)
location: region:171441-172286:-1
so has part: feature:171441-172286:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171441-172286:-1:exon

YNL252C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL46
alternative label: MRPL30
gene: MRPL17
locus tag: YNL252C
gene synonym: mL46; MRPL30
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL17/YmL30
translation: MKVNLMLKRGLATATATASSAPPKIKVGVLLSRIPIIKSELNELEKKYYEYQSELEKRLMWTFPAYFYFKKGTVAEHKFLSLQKGPISKKNGIWFPRGIPDIKHGRERSTKQEVKLSDDSTVAFSNNQKEQSKDDVNRPVIPNDRITEADRSNDMKSLERQLSRTLYLLVKDKSGTWKFPNFDLSDESKPLHVHAENELKLLSGDQIYTWSVSATPIGVLQDERNRTAEFIVKSHILAGKFDLVASKNDAFEDFAWLTKGEISEYVPKDYFNKTEFLLADN
SIO_010081: YNL252C
subclass of: SO_0000673
so part of: YNL252C
location: complement(171441..172286)
location: region:171441-172286:-1
so has part: feature:171441-172286:-1:exon

NP_014147.1
type: Protein
SIO_000068: ncbiprotein

S000005196
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171441-172286:-1:exon

YNL251C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRD1
locus tag: YNL251C
so part of: sequence
location: complement(<172588..>174315)
location: region:172588-174315:-1
so has part: feature:172588-174315:-1:exon
subclass of: SO_0000010

855470
type: Gene
SIO_000068: ncbigene

position:172588:-1
position: 172588
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174315:-1
position: 174315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172588-174315:-1:exon

YNL251C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRD1
locus tag: YNL251C
product: Nrd1 complex RNA-binding subunit
transcript id: NM_001183089.1
SIO_010081: YNL251C
subclass of: SO_0000673
so part of: YNL251C
location: complement(<172588..>174315)
location: region:172588-174315:-1
so has part: feature:172588-174315:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172588-174315:-1:exon

YNL251C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRD1
locus tag: YNL251C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:21084293]
experiment: EXISTENCE:direct assay:GO:0001068 transcription regulatory region RNA binding [PMID:21084293]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9618475]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:18660819]
experiment: EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:16427013]
experiment: EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:10655211]
experiment: EXISTENCE:direct assay:GO:0071041 antisense RNA transcript catabolic process [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]
experiment: EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]
experiment: EXISTENCE:mutant phenotype:GO:0034472 snRNA 3'-end processing [PMID:11565036]
experiment: EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:21460797]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:21113025]
experiment: EXISTENCE:mutant phenotype:GO:0071034 CUT catabolic process [PMID:16973436]
experiment: EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:22028667]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]
note: RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size
codon start: 1
product: Nrd1 complex RNA-binding subunit
translation: MQQDDDFQNFVATLESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLDETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLNAIRSKCFAMDISNNTANTASQQLSLDPKQRSKQILSNLKKSPPLNLNISLPTDLTSTDPAKQQAALFQVIAALQKHFKTLPSHTSVGTVAPPQAHTITEYGSRRERERERERYNSRRNRSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTTFGTNNHHLYPDELNVSNNPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKPFAEVQSVILNNSRKHAFVKVYSRHEAENVLQNFNKDGALPLRTRWGVGFGPRDCCDYQHGYSIIPMHRLTDADKKWSVSAQWGGTSGQPLVTGIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNAPLASPPPQQYVQPMMQQPYGYAPNQPLPSQGPAAAAPPVPQQQFDPTAQLNSLMNMLNQQQQQQQQS
SIO_010081: YNL251C
subclass of: SO_0000673
so part of: YNL251C
location: complement(172588..174315)
location: region:172588-174315:-1
so has part: feature:172588-174315:-1:exon

NP_014148.1
type: Protein
SIO_000068: ncbiprotein

S000005195
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172588-174315:-1:exon

YNL250W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD50
locus tag: YNL250W
so part of: sequence
location: <175410..>179348
location: region:175410-179348:1
so has part: feature:175410-179348:1:exon
subclass of: SO_0000010

855471
type: Gene
SIO_000068: ncbigene

position:175410:1
position: 175410
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:179348:1
position: 179348
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175410-179348:1:exon

YNL250W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD50
locus tag: YNL250W
product: MRX complex DNA-binding subunit
transcript id: NM_001183088.1
SIO_010081: YNL250W
subclass of: SO_0000673
so part of: YNL250W
location: <175410..>179348
location: region:175410-179348:1
so has part: feature:175410-179348:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175410-179348:1:exon

YNL250W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD50
locus tag: YNL250W
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:8367302]
experiment: EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:17698079]
experiment: EXISTENCE:direct assay:GO:0004017 adenylate kinase activity [PMID:17349953]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9845372|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15546877]
experiment: EXISTENCE:direct assay:GO:0032078 negative regulation of endodeoxyribonuclease activity [PMID:17698079]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15721260]
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17698079]
experiment: EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:17698079]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17349953]
experiment: EXISTENCE:mutant phenotype:GO:0004017 adenylate kinase activity [PMID:17349953]
experiment: EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:20040573]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380|PMID:9501103|PMID:31390569]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:8207053]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:27173583]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17349953]
experiment: EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]
experiment: EXISTENCE:physical interaction:GO:0030870 Mre11 complex [PMID:9845372]
note: Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
codon start: 1
product: MRX complex DNA-binding subunit
translation: MSAIYKLSIQGIRSFDSNDRETIEFGKPLTLIVGMNGSGKTTIIECLKYATTGDLPPNSKGGVFIHDPKITGEKDIRAQVKLAFTSANGLNMIVTRNIQLLMKKTTTTFKTLEGQLVAINNSGDRSTLSTRSLELDAQVPLYLGVPKAILEYVIFCHQEDSLWPLSEPSNLKKKFDEIFQAMKFTKALDNLKSIKKDMSVDIKLLKQSVEHLKLDKDRSKAMKLNIHQLQTKIDQYNEEVSEIESQLNEITEKSDKLFKSNQDFQKILSKVENLKNTKLSISDQVKRLSNSIDILDLSKPDLQNLLANFSKVLMDKNNQLRDLETDISSLKDRQSSLQSLSNSLIRRQGELEAGKETYEKNRNHLSSLKEAFQHKFQGLSNIENSDMAQVNHEMSQFKAFISQDLTDTIDQFAKDIQLKETNLSDLIKSITVDSQNLEYNKKDRSKLIHDSEELAEKLKSFKSLSTQDSLNHELENLKTYKEKLQSWESENIIPKLNQKIEEKNNEMIILENQIEKFQDRIMKTNQQADLYAKLGLIKKSINTKLDELQKITEKLQNDSRIRQVFPLTQEFQRADLEMDFQKLFINMQKNIAINNKKMHELDRRYTNALYNLNTIEKDLQDNQKSKEKVIQLLSENLPEDCTIDEYNDVLEETELSYKTALENLKMHQTTLEFNRKALEIAERDSCCYLCSRKFENESFKSKLLQELKTKTDANFEKTLKDTVQNEKEYLHSLRLLEKHIITLNSINEKIDNSQKCLEKAKEETKTSKSKLDELEVDSTKLKDEKELAESEIRPLIEKFTYLEKELKDLENSSKTISEELSIYNTSEDGIQTVDELRDQQRKMNDSLRELRKTISDLQMEKDEKVRENSRMINLIKEKELTVSEIESSLTQKQNIDDSIRSKRENINDIDSRVKELEARIISLKNKKDEAQSVLDKVKNERDIQVRNKQKTVADINRLIDRFQTIYNEVVDFEAKGFDELQTTIKELELNKAQMLELKEQLDLKSNEVNEEKRKLADSNNEEKNLKQNLELIELKSQLQHIESEISRLDVQNAEAERDKYQEESLRLRTRFEKLSSENAGKLGEMKQLQNQIDSLTHQLRTDYKDIEKNYHKEWVELQTRSFVTDDIDVYSKALDSAIMKYHGLKMQDINRIIDELWKRTYSGTDIDTIKIRSDEVSSTVKGKSYNYRVVMYKQDVELDMRGRCSAGQKVLASIIIRLALSETFGANCGVIALDEPTTNLDEENIESLAKSLHNIINMRRHQKNFQLIVITHDEKFLGHMNAAAFTDHFFKVKRDDRQKSQIEWVDINRVTY
SIO_010081: YNL250W
subclass of: SO_0000673
so part of: YNL250W
location: 175410..179348
location: region:175410-179348:1
so has part: feature:175410-179348:1:exon

NP_014149.1
type: Protein
SIO_000068: ncbiprotein

S000005194
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175410-179348:1:exon

YNL249C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPA43
locus tag: YNL249C
so part of: sequence
location: complement(<179394..>181022)
location: region:179394-181022:-1
so has part: feature:179394-181022:-1:exon
subclass of: SO_0000010

855472
type: Gene
SIO_000068: ncbigene

position:179394:-1
position: 179394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181022:-1
position: 181022
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:179394-181022:-1:exon

YNL249C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPA43
locus tag: YNL249C
product: Mpa43p
transcript id: NM_001183087.1
SIO_010081: YNL249C
subclass of: SO_0000673
so part of: YNL249C
location: complement(<179394..>181022)
location: region:179394-181022:-1
so has part: feature:179394-181022:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:179394-181022:-1:exon

YNL249C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPA43
locus tag: YNL249C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Mpa43p
translation: MNSSLQVGIGIDVGSSSARIGVYNYYNDALLEMAQEPVPYYQDSSKKSWKFWQKSTEIIKALQKCLQKLNIREYEVKSCGVSATCSLAIFERDRTSNMLIPYPNEDNVIFWMDSSAVNECQWLNMQCPQQLLDYLGGKFVPEMGVPKLKYFLDEYSHLRDKHFHIFDLHQYIAYELSRLYEWNIEGLLGRENLNGIGNDGEVSGWSSSFYKNIINLPSNVSIGTTSLVANKHISTTVVRSCIDSYASWFAVASPHLETSLFMIAGTSSCYMYGTTISDTRIPGVWGPFDTILDNRGDFSVYAAGQSCTGKLIEHLFESHPCARKILKDGADIYQVLEQTIRDIEKNNGLSIHILTKDMFFYGDYEGNRTPFADPRIKGSFIGESTDTSMLNLTYKYICILEFLSFQTKLIIDTFQNENSNIHIKELRISGSQAKNERLLSLISLVNNGVAIIKPKENVDMMGIKGAYVLAKSAKEKKQLADVITERDISNDSEKFESLAEYRLGNDSILLRKLLCVKYHIHLDMAKQQKRYHKLVDEVFQHL
SIO_010081: YNL249C
subclass of: SO_0000673
so part of: YNL249C
location: complement(179394..181022)
location: region:179394-181022:-1
so has part: feature:179394-181022:-1:exon

NP_014150.1
type: Protein
SIO_000068: ncbiprotein

S000005193
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:179394-181022:-1:exon

YNL248C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPA49
locus tag: YNL248C
so part of: sequence
location: complement(<181361..>182608)
location: region:181361-182608:-1
so has part: feature:181361-182608:-1:exon
subclass of: SO_0000010

855473
type: Gene
SIO_000068: ncbigene

position:181361:-1
position: 181361
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:182608:-1
position: 182608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181361-182608:-1:exon

YNL248C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPA49
locus tag: YNL248C
product: DNA-directed RNA polymerase I subunit RPA49
transcript id: NM_001183086.1
SIO_010081: YNL248C
subclass of: SO_0000673
so part of: YNL248C
location: complement(<181361..>182608)
location: region:181361-182608:-1
so has part: feature:181361-182608:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181361-182608:-1:exon

YNL248C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPA49
locus tag: YNL248C
experiment: EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21263028]
experiment: EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:18160037]
experiment: EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]
experiment: EXISTENCE:mutant phenotype:GO:0005736 RNA polymerase I complex [PMID:1409638]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:12374750]
note: RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p
codon start: 1
product: DNA-directed RNA polymerase I subunit RPA49
translation: MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTRPSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDEITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNSKYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILSRFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKVVSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR
SIO_010081: YNL248C
subclass of: SO_0000673
so part of: YNL248C
location: complement(181361..182608)
location: region:181361-182608:-1
so has part: feature:181361-182608:-1:exon

NP_014151.1
type: Protein
SIO_000068: ncbiprotein

S000005192
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181361-182608:-1:exon

YNL247W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRS1
locus tag: YNL247W
so part of: sequence
location: <182875..>185178
location: region:182875-185178:1
so has part: feature:182875-185178:1:exon
subclass of: SO_0000010

855474
type: Gene
SIO_000068: ncbigene

position:182875:1
position: 182875
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185178:1
position: 185178
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182875-185178:1:exon

YNL247W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRS1
locus tag: YNL247W
product: cysteine--tRNA ligase
transcript id: NM_001183085.1
SIO_010081: YNL247W
subclass of: SO_0000673
so part of: YNL247W
location: <182875..>185178
location: region:182875-185178:1
so has part: feature:182875-185178:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:182875-185178:1:exon

YNL247W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRS1
locus tag: YNL247W
EC number: 6.1.1.16
experiment: EXISTENCE:direct assay:GO:0004817 cysteine-tRNA ligase activity [PMID:9523015]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31350340]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31350340]
experiment: EXISTENCE:direct assay:GO:0006423 cysteinyl-tRNA aminoacylation [PMID:9523015]
note: Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid
codon start: 1
product: cysteine--tRNA ligase
translation: MNIFIKALRRYTIMSTPKIVQPKWKVPTPQAKETVLKLYNSLTRSKVEFIPQSGNRGVTWYSCGPTVYDASHMGHARNYVSIDINRRIIQDYFGYDVQFVQNVTDIDDKIILRARQNYLFDNFVKENDTKFNATVVDKVKTALFQYINKNFTIQGSEIKTIEEFETWLSNADTETLKLENPKFPMHVTAVQNAIESITKGDSMDAEVAFEKVKDVTVPLLDKELGSTISNPEIFRQLPAYWEQKFNDDMLSLNVLPPTVTTRVSEYVPEIIDFVQKIIDNGYAYATSDGSVYFDTLKFDKSPNHDYAKCQPWNKGQLDLINDGEGSLSNFADNGKKSNNDFALWKASKAGEPEWESPWGKGRPGWHIECSVMASDILGSNIDIHSGGIDLAFPHHDNELAQSEARFDNQQWINYFLHTGHLHIEGQKMSKSLKNFITIQEALKKFSPRQLRLAFASVQWNNQLDFKESLIHEVKSFENSMNNFFKTIRALKNDAASAGHISKKFSPLEKELLADFVESESKVHSAFCDNLSTPVALKTLSELVTKSNTYITTAGAALKIEPLIAICSYITKILRIIGFPSRPDNLGWAAQAGSNDGSLGSLEDTVMPYVKCLSTFRDDVRSLAIKKAEPKEFLQLTDKIRNEDLLNLNVALDDRNGQSALIKFLTNDEKLEIVKLNEEKHANELAKKQKKLEQQKLREQKENERKQKAQIKPQDMFKDVTLYSAWDEQGLPTKDKDGNDITKSMTKKLKKQWEQQKKLHEEYFGEDK
SIO_010081: YNL247W
subclass of: SO_0000673
so part of: YNL247W
location: 182875..185178
location: region:182875-185178:1
so has part: feature:182875-185178:1:exon

NP_014152.1
type: Protein
SIO_000068: ncbiprotein

S000005191
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:182875-185178:1:exon

YNL246W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VPS75
locus tag: YNL246W
so part of: sequence
location: <185460..>186349
location: region:185460-186349:1
so has part: feature:185460-186349:1:exon
subclass of: SO_0000010

855475
type: Gene
SIO_000068: ncbigene

position:185460:1
position: 185460
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186349:1
position: 186349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185460-186349:1:exon

YNL246W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VPS75
locus tag: YNL246W
product: Vps75p
transcript id: NM_001183084.1
SIO_010081: YNL246W
subclass of: SO_0000673
so part of: YNL246W
location: join(<185460..185491,185587..>186349)
location: region:185460-186349:1
so has part: feature:185460-185491:1:exon
so has part: feature:185587-186349:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185460-185491:1:exon

position:185491:1
position: 185491
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:185587-186349:1:exon

position:185587:1
position: 185587
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL246W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VPS75
locus tag: YNL246W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17344218]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:17344218]
experiment: EXISTENCE:direct assay:GO:0010698 acetyltransferase activator activity [PMID:19172749]
experiment: EXISTENCE:direct assay:GO:0035066 positive regulation of histone acetylation [PMID:18458063]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17344218]
experiment: EXISTENCE:genetic interaction:GO:0035066 positive regulation of histone acetylation [PMID:18458063]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]
experiment: EXISTENCE:mutant phenotype:GO:0010698 acetyltransferase activator activity [PMID:19172749]
experiment: EXISTENCE:mutant phenotype:GO:0035066 positive regulation of histone acetylation [PMID:18458063]
experiment: EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]
experiment: EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17344218]
note: NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Vps75p
translation: MMSDQENENEHAKAFLGLAKCEEEVDAIEREVELYRLNKMKPVYEKRDAYIDEIAEFWKIVLSQHVSFANYIRASDFKYIDTIDKIKVEWLALESEMYDTRDFSITFHFHGIEGDFKEQQVTKVFQIKKGKDDQEDGILTSEPVPIEWPQSYDSINPDLIKDKRSPEGKKKYRQGMKTIFGWFRWTGLKPGKEFPHGDSLASLFSEEIYPFCVKYYAEAQRDLEDEEGESGLSADGDSEDDDGSLGEVDLPLSDEEPSSKKRKV
SIO_010081: YNL246W
subclass of: SO_0000673
so part of: YNL246W
location: join(185460..185491,185587..186349)
location: region:185460-186349:1
so has part: feature:185460-185491:1:exon
so has part: feature:185587-186349:1:exon

NP_014153.1
type: Protein
SIO_000068: ncbiprotein

S000005190
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185460-185491:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:185587-186349:1:exon

YNL245C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CWC25
locus tag: YNL245C
so part of: sequence
location: complement(<186346..>186885)
location: region:186346-186885:-1
so has part: feature:186346-186885:-1:exon
subclass of: SO_0000010

855476
type: Gene
SIO_000068: ncbigene

position:186346:-1
position: 186346
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186885:-1
position: 186885
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:186346-186885:-1:exon

YNL245C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CWC25
locus tag: YNL245C
product: U2-type spliceosomal complex subunit CWC25
transcript id: NM_001183083.1
SIO_010081: YNL245C
subclass of: SO_0000673
so part of: YNL245C
location: complement(<186346..>186885)
location: region:186346-186885:-1
so has part: feature:186346-186885:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:186346-186885:-1:exon

YNL245C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CWC25
locus tag: YNL245C
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:19935684]
experiment: EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]
note: Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
codon start: 1
product: U2-type spliceosomal complex subunit CWC25
translation: MGSGDLNLLKSWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKERELNELLNESSKDKPETLKNDLALKKSGLEWMYQDAKLSDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKDDPMSKFKVTKQQRRTPDSTKKRAMSQRGKPLSKPAPDLDY
SIO_010081: YNL245C
subclass of: SO_0000673
so part of: YNL245C
location: complement(186346..186885)
location: region:186346-186885:-1
so has part: feature:186346-186885:-1:exon

NP_014154.1
type: Protein
SIO_000068: ncbiprotein

S000005189
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:186346-186885:-1:exon

YNL244C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MOF2
alternative label: RFR1
gene: SUI1
locus tag: YNL244C
gene synonym: MOF2; RFR1
so part of: sequence
location: complement(<187170..>187496)
location: region:187170-187496:-1
so has part: feature:187170-187496:-1:exon
subclass of: SO_0000010

855477
type: Gene
SIO_000068: ncbigene

position:187170:-1
position: 187170
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187496:-1
position: 187496
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187170-187496:-1:exon

YNL244C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MOF2
alternative label: RFR1
gene: SUI1
locus tag: YNL244C
gene synonym: MOF2; RFR1
product: translation initiation factor eIF1
transcript id: NM_001183082.1
SIO_010081: YNL244C
subclass of: SO_0000673
so part of: YNL244C
location: complement(<187170..>187496)
location: region:187170-187496:-1
so has part: feature:187170-187496:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187170-187496:-1:exon

YNL244C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MOF2
alternative label: RFR1
gene: SUI1
locus tag: YNL244C
gene synonym: MOF2; RFR1
experiment: EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673|PMID:15664195|PMID:17434125|PMID:17504939]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]
experiment: EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]
experiment: EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:12861028|PMID:15145951]
experiment: EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:17434125|PMID:19751744|PMID:12860115]
experiment: EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]
experiment: EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:17504939|PMID:19751744]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:19751744]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:9488467]
experiment: EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:12861028|PMID:15145951|PMID:22851688]
note: Translation initiation factor eIF1; component of complex involved in recognition of initiator codon; modulates translation accuracy at initiation phase by discriminating against suboptimal initiation sites to prevent excessive uORF translation genome-wide
codon start: 1
product: translation initiation factor eIF1
translation: MSIENLKSFDPFADTGDDETATSNYIHIRIQQRNGRKTLTTVQGVPEEYDLKRILKVLKKDFACNGNIVKDPEMGEIIQLQGDQRAKVCEFMISQLGLQKKNIKIHGF
SIO_010081: YNL244C
subclass of: SO_0000673
so part of: YNL244C
location: complement(187170..187496)
location: region:187170-187496:-1
so has part: feature:187170-187496:-1:exon

NP_014155.1
type: Protein
SIO_000068: ncbiprotein

S000005188
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187170-187496:-1:exon

YNL243W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: END4
alternative label: MOP2
gene: SLA2
locus tag: YNL243W
gene synonym: END4; MOP2
so part of: sequence
location: <188051..>190957
location: region:188051-190957:1
so has part: feature:188051-190957:1:exon
subclass of: SO_0000010

855478
type: Gene
SIO_000068: ncbigene

position:188051:1
position: 188051
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:190957:1
position: 190957
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:188051-190957:1:exon

YNL243W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: END4
alternative label: MOP2
gene: SLA2
locus tag: YNL243W
gene synonym: END4; MOP2
product: Sla2p
transcript id: NM_001183081.2
SIO_010081: YNL243W
subclass of: SO_0000673
so part of: YNL243W
location: <188051..>190957
location: region:188051-190957:1
so has part: feature:188051-190957:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:188051-190957:1:exon

YNL243W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: END4
alternative label: MOP2
gene: SLA2
locus tag: YNL243W
gene synonym: END4; MOP2
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11302750]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10397764]
experiment: EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:17151356]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:8335689]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10397764]
note: Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
codon start: 1
product: Sla2p
translation: MSRIDSDLQKALKKACSVEETAPKRKHVRACIVYTWDHQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAIRDRDWIRSLGRVHSGGSSYSKLIREYVRYLVLKLDFHAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFASIQSERRNTECKISALIPLIAESYGIYKFITSMLRAMHRQLNDAEGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVTIPKLPVDAPDVFLINDVDESKEIKFKKREPSVTPARTPARTPTPTPPVVAEPAISPRPVSQRTTSTPTGYLQTMPTGATTGMMIPTATGAANAIFPQATAQMQPDFWANQQAQFANEQNRLEQERVQQLQQQQAQQELFQQQLQKAQQDMMNMQLQQQNQHQNDLIALTNQYEKDQALLQQYDQRVQQLESEITTMDSTASKQLANKDEQLTALQDQLDVWERKYESLAKLYSQLRQEHLNLLPRFKKLQLKVNSAQESIQKKEQLEHKLKQKDLQMAELVKDRDRARLELERSINNAEADSAAATAAAETMTQDKMNPILDAILESGINTIQESVYNLDSPLSWSGPLTPPTFLLSLLESTSENATEFATSFNNLIVDGLAHGDQTEVIHCVSDFSTSMATLVTNSKAYAVTTLPQEQSDQILTLVKRCAREAQYFFEDLMSENLNQVGDEEKTDIVINANVDMQEKLQELSLAIEPLLNIQSVKSNKETNPHSELVATADKIVKSSEHLRVDVPKPLLSLALMIIDAVVALVKAAIQCQNEIATTTSIPLNQFYLKNSRWTEGLISAAKAVAGATNVLITTASKLITSEDNENTSPEQFIVASKEVAASTIQLVAASRVKTSIHSKAQDKLEHCSKDVTDACRSLGNHVMGMIEDDHSTSQQQQPLDFTSEHTLKTAEMEQQVEILKLEQSLSNARKRLGEIRRHAYYNQDDD
SIO_010081: YNL243W
subclass of: SO_0000673
so part of: YNL243W
location: 188051..190957
location: region:188051-190957:1
so has part: feature:188051-190957:1:exon

NP_014156.2
type: Protein
SIO_000068: ncbiprotein

S000005187
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:188051-190957:1:exon

YNL242W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG2
alternative label: AUT8
alternative label: SPO72
gene: ATG2
locus tag: YNL242W
gene synonym: APG2; AUT8; SPO72
so part of: sequence
location: <191324..>196102
location: region:191324-196102:1
so has part: feature:191324-196102:1:exon
subclass of: SO_0000010

855479
type: Gene
SIO_000068: ncbigene

position:191324:1
position: 191324
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196102:1
position: 196102
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:191324-196102:1:exon

YNL242W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG2
alternative label: AUT8
alternative label: SPO72
gene: ATG2
locus tag: YNL242W
gene synonym: APG2; AUT8; SPO72
product: Atg2p
transcript id: NM_001183080.1
SIO_010081: YNL242W
subclass of: SO_0000673
so part of: YNL242W
location: <191324..>196102
location: region:191324-196102:1
so has part: feature:191324-196102:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:191324-196102:1:exon

YNL242W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG2
alternative label: AUT8
alternative label: SPO72
gene: ATG2
locus tag: YNL242W
gene synonym: APG2; AUT8; SPO72
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:11689437|PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11382760|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030242 autophagy of peroxisome [PMID:11382760]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:27498190]
experiment: EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]
experiment: EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:11382761]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:11382760]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:11382761]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]
note: Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: Atg2p
translation: MAFWLPQNIQKRLLLYVLQQISLFSNIDLSNLDVSIGSKSHFSFHDVNLSLDDLNIPNVQINEGIVDELVLKLTVSGGVEIDGSGLRFIMTPLYSSGSQELHSDFLVKSIQDLTNSMLQFSDPLTTYNRYKEDDISSSDSSSDLNSNIEASKPAANGSYTLQNMRNKALNVALAKLKIALKDVTIRFIVNDRDPSDNIVEVHLESIQLITTDANLRHINIENITISSIQKQAVPDSPVHPFNNDDLSQSVYLSKMEATSLYMSAMEEQSNEDPSEPQVTQEEQENDKCKESLMEINNLNIAFKGLSSVNDLRMSNIVIDIQDVHLAIHKIVEIKNSTLKNIIDIIVTHLDANESFSCQDSQSPSPDKQEPSALSSVDIKCIYLNLGQDITVILKSFKLEQKENNSLAFSLGSFYSNSSPLTISHKTKPLLTGEQTPQSIALNMGDELDIIISHDGIAHFFKIFQFVSKCMSFYQNKSKGMMPQIASDTKRTVQLTSKAVKLSLKFPYFLLCFQVSPFIYDSNRELYIELVDVFKKLPSRCTKILTMSSITISNLQSPLQLGSYDDTLKEALIYSSVHAIIKEVIFNEEYSGIVQLVEDISAFGKLFTDSKNSECTGKSKSKRGSFLQRSVRVLNSSRFVYKQSLSANFSLKIDSMKLKVSEIIGPQFGSVEALLSNNFFAITDDSQIVYFTKNLKVERKTPSLLEPQEIMSVVLNKAVNEPVLYVHRRANGKLKVIFNNIRIHYYARWLEILKKNIGPDNASSKDEPVSQKLSKKQPTSGFPWELKCLDCSLILHPFRLKSVMVIVLDNLTTGGSSFIPQAKLLSKANTLFLIDDYQNFKIQKDKNWPSLINFYAGQGFSAIGKIDTLNFLINKSDGALLLDCKIEQVGLSLCADSFQTFCQLCIDLKYPQTFPDEEKFRTQLKNPIDVFKDIDCDLFNSAFIRENNHQNDYDSVHLVDSFLDKTHEFNNGARSKLSSQGSYEMDSSSGTATGGILLPHESYLDSAQPKEEDTPPIASKEQERDVDIRGSIDVEKVVIKLFDGYDWKYTRKFIANTVEKLDKELSKAEASSSKSNVPQSEANIFDSIYISANKNNVTDLRRNLDGEIQGVQNSFSDVSKVNLRPSKHYKALIQLNKVHVNLKNYRVDEPDESNSDNSTDVLNRCVVSIYEFEIIDNVPTSTWNKFVTLLKHEPWPHSSPMFLLDLEFIRPIDFLQAVELVMQLNVAPLRLHVDQDTLEFLIRFLGFKDKRFELIDEYPDIVFIQKFSTNSIKLRLDYKPKKVDYAGLRSGQTSELMNFFTLDGSKIILKSVVLYGLNGFDELNNKLKAIWTPDITKKQLPGVLEGLAPVRSFMAIGSGVKTLVTVLMSEYRQEGHLGRSLKKGGNVFLKTTTGDFVKLGVKLTSGTQAILENTEELFGGVGSNGRVYDASKFGSADGADSDTAAVLDLDTLFEEDQLVGSKYSRIRDHEPTAVVIDMSSPGDHNEPTIVSLYADQPLDLPTGLKEAYSSLEKHMHIAYDAVWRAKGQMKDDKRGGPSAAAVYVARAAPVAIIRPLIGATEAVSKTLQGIANQVDKTHNEQINDKYKSNRTDS
SIO_010081: YNL242W
subclass of: SO_0000673
so part of: YNL242W
location: 191324..196102
location: region:191324-196102:1
so has part: feature:191324-196102:1:exon

NP_014157.1
type: Protein
SIO_000068: ncbiprotein

S000005186
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:191324-196102:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1412; ARS activated in late S phase
so part of: sequence
location: 196134..196232
location: region:196134-196232:1
so has part: feature:196134-196232:1:region

S000077374
type: SGD
SIO_000068: sgd

position:196134:1
position: 196134
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:196232:1
position: 196232
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196134-196232:1:region

YNL241C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MET19
alternative label: POS10
gene: ZWF1
locus tag: YNL241C
gene synonym: MET19; POS10
so part of: sequence
location: complement(<196426..>197943)
location: region:196426-197943:-1
so has part: feature:196426-197943:-1:exon
subclass of: SO_0000010

855480
type: Gene
SIO_000068: ncbigene

position:196426:-1
position: 196426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:197943:-1
position: 197943
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196426-197943:-1:exon

YNL241C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MET19
alternative label: POS10
gene: ZWF1
locus tag: YNL241C
gene synonym: MET19; POS10
product: glucose-6-phosphate dehydrogenase
transcript id: NM_001183079.1
SIO_010081: YNL241C
subclass of: SO_0000673
so part of: YNL241C
location: complement(<196426..>197943)
location: region:196426-197943:-1
so has part: feature:196426-197943:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196426-197943:-1:exon

YNL241C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MET19
alternative label: POS10
gene: ZWF1
locus tag: YNL241C
gene synonym: MET19; POS10
EC number: 1.1.1.49
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0004345 glucose-6-phosphate dehydrogenase activity [PMID:2001672|PMID:2269430]
experiment: EXISTENCE:mutant phenotype:GO:0006740 NADPH regeneration [PMID:2269430]
experiment: EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:7045591|PMID:8299150]
experiment: EXISTENCE:mutant phenotype:GO:0042542 response to hydrogen peroxide [PMID:7586028|PMID:9480895]
note: Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant
codon start: 1
product: glucose-6-phosphate dehydrogenase
translation: MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN
SIO_010081: YNL241C
subclass of: SO_0000673
so part of: YNL241C
location: complement(196426..197943)
location: region:196426-197943:-1
so has part: feature:196426-197943:-1:exon

NP_014158.1
type: Protein
SIO_000068: ncbiprotein

S000005185
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196426-197943:-1:exon

YNL240C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAR1
locus tag: YNL240C
so part of: sequence
location: complement(<198502..>199977)
location: region:198502-199977:-1
so has part: feature:198502-199977:-1:exon
subclass of: SO_0000010

855481
type: Gene
SIO_000068: ncbigene

position:198502:-1
position: 198502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:199977:-1
position: 199977
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198502-199977:-1:exon

YNL240C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAR1
locus tag: YNL240C
product: iron-sulfur cluster assembly protein NAR1
transcript id: NM_001183078.1
SIO_010081: YNL240C
subclass of: SO_0000673
so part of: YNL240C
location: complement(<198502..>199977)
location: region:198502-199977:-1
so has part: feature:198502-199977:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198502-199977:-1:exon

YNL240C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAR1
locus tag: YNL240C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15103330]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15103330]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15103330]
note: Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf
codon start: 1
product: iron-sulfur cluster assembly protein NAR1
translation: MSALLSESDLNDFISPALACVKPTQVSGGKKDNVNMNGEYEVSTEPDQLEKVSITLSDCLACSGCITSSEEILLSSQSHSVFLKNWGKLSQQQDKFLVVSVSPQCRLSLAQYYGLTLEAADLCLMNFFQKHFQCKYMVGTEMGRIISISKTVEKIIAHKKQKENTGADRKPLLSAVCPGFLIYTEKTKPQLVPMLLNVKSPQQITGSLIRATFESLAIARESFYHLSLMPCFDKKLEASRPESLDDGIDCVITPREIVTMLQELNLDFKSFLTEDTSLYGRLSPPGWDPRVHWASNLGGTCGGYAYQYVTAVQRLHPGSQMIVLEGRNSDIVEYRLLHDDRIIAAASELSGFRNIQNLVRKLTSGSGSERKRNITALRKRRTGPKANSREMAAATAATADPYHSDYIEVNACPGACMNGGGLLNGEQNSLKRKQLVQTLNKRHGEELAMVDPLTLGPKLEEAAARPLSLEYVFAPVKQAVEKDLVSVGSTW
SIO_010081: YNL240C
subclass of: SO_0000673
so part of: YNL240C
location: complement(198502..199977)
location: region:198502-199977:-1
so has part: feature:198502-199977:-1:exon

NP_014159.1
type: Protein
SIO_000068: ncbiprotein

S000005184
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198502-199977:-1:exon

YNL239W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BLH1
alternative label: GAL6
alternative label: YCP1
gene: LAP3
locus tag: YNL239W
gene synonym: BLH1; GAL6; YCP1
so part of: sequence
location: <200569..>201933
location: region:200569-201933:1
so has part: feature:200569-201933:1:exon
subclass of: SO_0000010

855482
type: Gene
SIO_000068: ncbigene

position:200569:1
position: 200569
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201933:1
position: 201933
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:200569-201933:1:exon

YNL239W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BLH1
alternative label: GAL6
alternative label: YCP1
gene: LAP3
locus tag: YNL239W
gene synonym: BLH1; GAL6; YCP1
product: bleomycin hydrolase
transcript id: NM_001183077.1
SIO_010081: YNL239W
subclass of: SO_0000673
so part of: YNL239W
location: <200569..>201933
location: region:200569-201933:1
so has part: feature:200569-201933:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:200569-201933:1:exon

YNL239W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BLH1
alternative label: GAL6
alternative label: YCP1
gene: LAP3
locus tag: YNL239W
gene synonym: BLH1; GAL6; YCP1
EC number: 3.4.22.40
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8063738]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:9584198]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9584198]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19061865|PMID:9584198|PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:8063738]
experiment: EXISTENCE:direct assay:GO:0043418 homocysteine catabolic process [PMID:16769724]
experiment: EXISTENCE:direct assay:GO:0046677 response to antibiotic [PMID:8063738]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9374524]
experiment: EXISTENCE:mutant phenotype:GO:0043418 homocysteine catabolic process [PMID:16769724]
note: Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; targeted to vacuole via CVT pathway; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
codon start: 1
product: bleomycin hydrolase
translation: MSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTRLQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFELSQAYLFFYDKLEKANYFLDQIVSSADQDIDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPKDLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSIIVTLREQMQREIFRLMSLFMDIPPVQPNEQFTWEYVDKDKKIHTIKSTPLEFASKYAKLDPSTPVSLINDPRHPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKKTGVMDIELWNYPAIGYNLPQQKASRIRYHESLMTHAMLITGCHVDETSKLPLRYRVENSWGKDSGKDGLYVMTQKYFEEYCFQIVVDINELPKELASKFTSGKEEPIVLPIWDPMGALAK
SIO_010081: YNL239W
subclass of: SO_0000673
so part of: YNL239W
location: 200569..201933
location: region:200569-201933:1
so has part: feature:200569-201933:1:exon

NP_014160.2
type: Protein
SIO_000068: ncbiprotein

S000005183
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:200569-201933:1:exon

YNL238W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: QDS1
alternative label: SRB1
alternative label: VMA45
gene: KEX2
locus tag: YNL238W
gene synonym: QDS1; SRB1; VMA45
so part of: sequence
location: <202428..>204872
location: region:202428-204872:1
so has part: feature:202428-204872:1:exon
subclass of: SO_0000010

855483
type: Gene
SIO_000068: ncbigene

position:202428:1
position: 202428
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204872:1
position: 204872
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202428-204872:1:exon

YNL238W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: QDS1
alternative label: SRB1
alternative label: VMA45
gene: KEX2
locus tag: YNL238W
gene synonym: QDS1; SRB1; VMA45
product: kexin KEX2
transcript id: NM_001183076.1
SIO_010081: YNL238W
subclass of: SO_0000673
so part of: YNL238W
location: <202428..>204872
location: region:202428-204872:1
so has part: feature:202428-204872:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:202428-204872:1:exon

YNL238W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: QDS1
alternative label: SRB1
alternative label: VMA45
gene: KEX2
locus tag: YNL238W
gene synonym: QDS1; SRB1; VMA45
EC number: 3.4.21.61
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004252 serine-type endopeptidase activity [PMID:2646633]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]
experiment: EXISTENCE:mutant phenotype:GO:0007323 peptide pheromone maturation [PMID:6430565]
note: Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
codon start: 1
product: kexin KEX2
translation: MKVRKYITLCFWWAFSTSALVSSQQIPLKDHTSRQYFAVESNETLSRLEEMHPNWKYEHDVRGLPNHYVFSKELLKLGKRSSLEELQGDNNDHILSVHDLFPRNDLFKRLPVPAPPMDSSLLPVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSWDFNDNTNLPKPRLSDDYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSDINGRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEKSLQDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGVGDWKIKVKTTENGHRIDFHSWRLKLFGESIDSSKTETFVFGNDKEEVEPAATESTVSQYSASSTSISISATSTSSISIGVETSAIPQTTTASTDPDSDPNTPKKLSSPRQAMHYFLTIFLIGATFLVLYFMFFMKSRRRIRRSRAETYEFDIIDTDSEYDSTLDNGTSGITEPEEVEDFDFDLSDEDHLASLSSSENGDAEHTIDSVLTNENPFSDPIKQKFPNDANAESASNKLQELQPDVPPSSGRS
SIO_010081: YNL238W
subclass of: SO_0000673
so part of: YNL238W
location: 202428..204872
location: region:202428-204872:1
so has part: feature:202428-204872:1:exon

NP_014161.1
type: Protein
SIO_000068: ncbiprotein

S000005182
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202428-204872:1:exon

YNL237W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YTP1
locus tag: YNL237W
so part of: sequence
location: <205188..>206567
location: region:205188-206567:1
so has part: feature:205188-206567:1:exon
subclass of: SO_0000010

855484
type: Gene
SIO_000068: ncbigene

position:205188:1
position: 205188
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:206567:1
position: 206567
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205188-206567:1:exon

YNL237W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YTP1
locus tag: YNL237W
product: Ytp1p
transcript id: NM_001183075.1
SIO_010081: YNL237W
subclass of: SO_0000673
so part of: YNL237W
location: <205188..>206567
location: region:205188-206567:1
so has part: feature:205188-206567:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:205188-206567:1:exon

YNL237W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YTP1
locus tag: YNL237W
note: Probable type-III integral membrane hypothetical protein; has regions of similarity to mitochondrial electron transport proteins
codon start: 1
product: Ytp1p
translation: MTAANKNIVFGFSRSISAILLICFFFEKVCGDMEHDMGMDDTSGYTRPEIVQAGSKSFHWLCTLGFLLLLPSVVTCLSFAGRIYSATLLQCTCAVYAFLEAAVLRFQDNDGVENRTSRGTAWFLVGLTWITLFFGGLAGGTGFLVKSKRLQTFISNAGEKRLSYIHRGLSFLTVLTGWVKVCLAPVALFGFCREAHTGQCIAHGIMGSAFVLYGFIYVLVLVIPWIRSAQTSYSQDYVDSWVMCIWGVVNTFTEHRWGREGWSVHDYQHTFMGIIWWTGGILGIFLSRNGRRTFVPSLIIIFTGWAMSEHAQHLIISTKVHNMFGLVLMCGGALRIIEISFLLRDKRTLDKIHSFQYLAPFCLVCSGLLFMGANEEQLILVLRLGGDHSAYVLIIVSGAFLVYFWMIACLEFYLYLLEKGKQGFLPKSYELEEENNNVSFELDNISNEDVDEDTTPFNV
SIO_010081: YNL237W
subclass of: SO_0000673
so part of: YNL237W
location: 205188..206567
location: region:205188-206567:1
so has part: feature:205188-206567:1:exon

NP_014162.1
type: Protein
SIO_000068: ncbiprotein

S000005181
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205188-206567:1:exon

YNL236W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BEL2
alternative label: GAL22
alternative label: MED16
alternative label: RYE1
alternative label: SDI3
alternative label: SSF5
alternative label: SSN4
alternative label: SSX3
alternative label: TSF3
gene: SIN4
locus tag: YNL236W
gene synonym: BEL2; GAL22; MED16; RYE1; SDI3; SSF5; SSN4; SSX3; TSF3
so part of: sequence
location: <206930..>209854
location: region:206930-209854:1
so has part: feature:206930-209854:1:exon
subclass of: SO_0000010

855485
type: Gene
SIO_000068: ncbigene

position:206930:1
position: 206930
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:209854:1
position: 209854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:206930-209854:1:exon

YNL236W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BEL2
alternative label: GAL22
alternative label: MED16
alternative label: RYE1
alternative label: SDI3
alternative label: SSF5
alternative label: SSN4
alternative label: SSX3
alternative label: TSF3
gene: SIN4
locus tag: YNL236W
gene synonym: BEL2; GAL22; MED16; RYE1; SDI3; SSF5; SSN4; SSX3; TSF3
product: Sin4p
transcript id: NM_001183074.1
SIO_010081: YNL236W
subclass of: SO_0000673
so part of: YNL236W
location: <206930..>209854
location: region:206930-209854:1
so has part: feature:206930-209854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:206930-209854:1:exon

YNL236W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BEL2
alternative label: GAL22
alternative label: MED16
alternative label: RYE1
alternative label: SDI3
alternative label: SSF5
alternative label: SSN4
alternative label: SSX3
alternative label: TSF3
gene: SIN4
locus tag: YNL236W
gene synonym: BEL2; GAL22; MED16; RYE1; SDI3; SSF5; SSN4; SSX3; TSF3
experiment: EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:genetic interaction:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12558798]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]
experiment: EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription
codon start: 1
product: Sin4p
translation: MMLGEHLMSWSKTGIIAYSDSQSSNANICLTFLESINGINWRFHTPQKYVLHPQLHEVQYQESSSTLSTHSTTTSVNGSTTAGVGSTPNFGGNSNKSPPQFFYNISSIHWNNWFSLPGDMLAVCDELGNMTMLITGQRPDRATTYEKLTMVFQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRKEYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVYHPPFIKYACLAIRKNGQIDFWYQFSNSKDHKKITLQLLDTSNQRFKDLQWLEFARITPMNDDQCMLITTYSKLSKNISFYKLHVNWNLNATKPNVLNDPSLKIQFILSTTLDPTDDEGHVLKLENLHVVSKSSIEKDPSPEILVLYNVCDTSKSLVKRYRLAPTQLSAEYLVILKPDLNIDRNNSTNQIFQSRRYNLRRHSDIVLDKKVTLITSEMFDAFVSFYFEDGTIESYNQNDWKLETERLISQSQLGKFKNIIASPLSAGFNYGKLPLPPSVEWMKVSPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSLHKQISAEDLTIAAKTHILRISFLDRKRAKEFITTLLKSLYSFFNISPDAPKEIMDKIITSRPLQKIMLLQLELGSCFSQENIEEMARVILYLKNVLFAFNGVARNFHFAIEQISNNSNQQQNPKLFQTIFSKQDLIHSLIPVAKWFVKFITYLTQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPETSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAEIPPEYAKVGDFLLQYANNAVISHANAAAVYFADTSGLKISNSEFFNPEIFHLLQPLEEGLIIDTDKLPIKNRTSKSFSKLLYDDVTCDKLSVSEISDGKLKRCSRCGSVTRAGNIISSDKTIVPTSIQTKRWPTMYTRLCICSGMLFEMDG
SIO_010081: YNL236W
subclass of: SO_0000673
so part of: YNL236W
location: 206930..209854
location: region:206930-209854:1
so has part: feature:206930-209854:1:exon

NP_014163.1
type: Protein
SIO_000068: ncbiprotein

S000005180
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:206930-209854:1:exon

YNL234W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL234W
so part of: sequence
location: <210233..>211513
location: region:210233-211513:1
so has part: feature:210233-211513:1:exon
subclass of: SO_0000010

855487
type: Gene
SIO_000068: ncbigene

position:210233:1
position: 210233
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:211513:1
position: 211513
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210233-211513:1:exon

YNL234W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL234W
product: uncharacterized protein
transcript id: NM_001183072.1
SIO_010081: YNL234W
subclass of: SO_0000673
so part of: YNL234W
location: <210233..>211513
location: region:210233-211513:1
so has part: feature:210233-211513:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210233-211513:1:exon

YNL234W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL234W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0020037 heme binding [PMID:9988749]
note: hypothetical protein with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1
codon start: 1
product: uncharacterized protein
translation: MTGEKILHSQLLTNSDMSSGNVHHTKPMMYNVTLPSYNSSSIGPVDNLKINERPGSHDHSMRSEMSSKNSGSDFMPQSISRSEGSVYQVKIDRGDSPNTEGFDFKVNARDLLLLRMSWDILLREYLTPKELKVFQALLYSNKHITSTERPYLNTAPDGMISKTIDPTARPRKTKQRDNDNKVDTALFCSQFYDNLIAMDPLLEEYFPSLKHQAVSFCKVLDSAIDNLENVHVLDDYIVKLGKRHSRILGIKTVGFEVMGKAFMTTLQDRFGSFLTLELKNLWGQLYSYLANCMITAGKDPMEKIQPDFSYNGDSVVLNFSIPKLAMHDISTVNKLQMVKTKNATIPHNITQVPTNKIPTEILLDNSSTPIKSDRESTPPISPKGSGSTKPSIGSSTVVESNTKKNNYDEKIHLLQKTAQQKNCSIM
SIO_010081: YNL234W
subclass of: SO_0000673
so part of: YNL234W
location: 210233..211513
location: region:210233-211513:1
so has part: feature:210233-211513:1:exon

NP_014165.1
type: Protein
SIO_000068: ncbiprotein

S000005178
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210233-211513:1:exon

YNL233W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BNI4
locus tag: YNL233W
so part of: sequence
location: <211922..>214600
location: region:211922-214600:1
so has part: feature:211922-214600:1:exon
subclass of: SO_0000010

855488
type: Gene
SIO_000068: ncbigene

position:211922:1
position: 211922
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214600:1
position: 214600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:211922-214600:1:exon

YNL233W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BNI4
locus tag: YNL233W
product: Bni4p
transcript id: NM_001183071.1
SIO_010081: YNL233W
subclass of: SO_0000673
so part of: YNL233W
location: <211922..>214600
location: region:211922-214600:1
so has part: feature:211922-214600:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:211922-214600:1:exon

YNL233W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BNI4
locus tag: YNL233W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15470103|PMID:15901837]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0005940 septin ring [PMID:9314530|PMID:15901837]
experiment: EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:15901837]
experiment: EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:15470103]
experiment: EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:15470103]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12529424|PMID:9314530]
note: Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly
codon start: 1
product: Bni4p
translation: MSDSISDSKSSELLNSTFYSSTSINTLDHARTFRNSLILKEISDQSLNSSIKPCESVLDRDVESSVLQRSFGESNARDSEVQTVNMTTSPSLSALADILNERSKYADQKTRKAQNIESSIIEEEEEAEEQNNSINYHEDITGSRLSVREEANENLAMTSPNLIDIDGSNSIQVAPLSLPSFEEPDFLSTPRVKPDSQGPRSKVSTRRTILERDNNLPVKREENTIINSETESTTHSAPFLKEDPKPSPPSSKLYNPKVRLNKAEARKYTDSSAQRTTSAGSVLEDTSMHKKKKSIFSFLKKKEPKPVIGNNSVTNEKNKMSSSSTFSMNIQTSLKTPEKLKKKSHSSSSIFNSFLKGKIETSDSPRKEPMRQKKRTPKSKDKKQDTEQIIDAASVLSTESPLLRKNHDDTPVKIDHVTRSIDQRKPTPLNMDLILGGDKQINTPLQEHVREDDDAKNDLQLPTKDNFLSLDYEAPSPAFSKHDTGEVLFPKFLDNHEVDSIVSLERTRSTKSNKRSSMNSQRRSLTDTLSIKAQSEGMFITEASSVVLSTPDLTKSPASSILKNGRFEYSDNFSREHSYEGTTNEDFLDIKDDSGPLKKDDIFLESIEQKFDQLVMASDEEKTEVERDVPKPREEPLKKDSERQSVFADDDNELISDIMEFASFINFGDDDLNLDLDLGDTTASYATETPEPVGNDEVNRSGTFDTRNNKEDSYKERETQSYSAAGATTYGDERQGQLHTFEQDGSEINDNEFENEDFNKHIEQPIEVTPRNNAYLPEFEPNRPVSMSFKGLKAPRMNTSFIDSMTPDSPVKSDLTSLGEVYVNSNNDQGVRFSSQIILYDTYGEFEYDRHPEISTCNQLTPQLAQMIKLELNELKSAMEVHDDSRCYTHFY
SIO_010081: YNL233W
subclass of: SO_0000673
so part of: YNL233W
location: 211922..214600
location: region:211922-214600:1
so has part: feature:211922-214600:1:exon

NP_014166.1
type: Protein
SIO_000068: ncbiprotein

S000005177
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:211922-214600:1:exon

YNL232W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SKI4
gene: CSL4
locus tag: YNL232W
gene synonym: SKI4
so part of: sequence
location: <214923..>215801
location: region:214923-215801:1
so has part: feature:214923-215801:1:exon
subclass of: SO_0000010

855489
type: Gene
SIO_000068: ncbigene

position:214923:1
position: 214923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:215801:1
position: 215801
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214923-215801:1:exon

YNL232W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SKI4
gene: CSL4
locus tag: YNL232W
gene synonym: SKI4
product: exosome non-catalytic core subunit CSL4
transcript id: NM_001183070.1
SIO_010081: YNL232W
subclass of: SO_0000673
so part of: YNL232W
location: <214923..>215801
location: region:214923-215801:1
so has part: feature:214923-215801:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214923-215801:1:exon

YNL232W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SKI4
gene: CSL4
locus tag: YNL232W
gene synonym: SKI4
experiment: EXISTENCE:curator inference:GO:0043628 regulatory ncRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070651 nonfunctional rRNA decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11027292]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11027292]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:15935758|PMID:17643380]
experiment: EXISTENCE:genetic interaction:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:11027292|PMID:19060898]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]
experiment: EXISTENCE:mutant phenotype:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:11027292|PMID:19060898]
experiment: EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]
note: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed
codon start: 1
product: exosome non-catalytic core subunit CSL4
translation: MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLIQYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRTVKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVEDKPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRVKVIECFKPGDIVRAQVLSLGDGTNYYLTTARNDLGVVFARAANGAGGLMYATDWQMMTSPVTGATEKRKCAKPF
SIO_010081: YNL232W
subclass of: SO_0000673
so part of: YNL232W
location: 214923..215801
location: region:214923-215801:1
so has part: feature:214923-215801:1:exon

NP_014167.1
type: Protein
SIO_000068: ncbiprotein

S000005176
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214923-215801:1:exon

YNL231C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SFH3
gene: PDR16
locus tag: YNL231C
gene synonym: SFH3
so part of: sequence
location: complement(<215987..>217042)
location: region:215987-217042:-1
so has part: feature:215987-217042:-1:exon
subclass of: SO_0000010

855490
type: Gene
SIO_000068: ncbigene

position:215987:-1
position: 215987
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:217042:-1
position: 217042
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215987-217042:-1:exon

YNL231C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SFH3
gene: PDR16
locus tag: YNL231C
gene synonym: SFH3
product: phosphatidylinositol transporter
transcript id: NM_001183069.1
SIO_010081: YNL231C
subclass of: SO_0000673
so part of: YNL231C
location: complement(<215987..>217042)
location: region:215987-217042:-1
so has part: feature:215987-217042:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:215987-217042:-1:exon

YNL231C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SFH3
gene: PDR16
locus tag: YNL231C
gene synonym: SFH3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:12869188|PMID:24403601]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]
experiment: EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:31690622]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:29187527]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]
experiment: EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]
experiment: EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:9890948]
experiment: EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]
experiment: EXISTENCE:mutant phenotype:GO:0043942 negative regulation of sexual sporulation resulting in formation of a cellular spore [PMID:24403601]
note: Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
codon start: 1
product: phosphatidylinositol transporter
translation: MFKRFSKKKEAPEDPKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPGNSKIPPIGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLRGTHEKLLYPVKSESSTV
SIO_010081: YNL231C
subclass of: SO_0000673
so part of: YNL231C
location: complement(215987..217042)
location: region:215987-217042:-1
so has part: feature:215987-217042:-1:exon

NP_014168.1
type: Protein
SIO_000068: ncbiprotein

S000005175
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:215987-217042:-1:exon

YNL230C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ELA1
locus tag: YNL230C
so part of: sequence
location: complement(<217523..>218662)
location: region:217523-218662:-1
so has part: feature:217523-218662:-1:exon
subclass of: SO_0000010

855491
type: Gene
SIO_000068: ncbigene

position:217523:-1
position: 217523
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218662:-1
position: 218662
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217523-218662:-1:exon

YNL230C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ELA1
locus tag: YNL230C
product: elongin A
transcript id: NM_001183068.1
SIO_010081: YNL230C
subclass of: SO_0000673
so part of: YNL230C
location: complement(<217523..>218662)
location: region:217523-218662:-1
so has part: feature:217523-218662:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217523-218662:-1:exon

YNL230C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ELA1
locus tag: YNL230C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:17296727]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17296727]
experiment: EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]
experiment: EXISTENCE:physical interaction:GO:0070449 elongin complex [PMID:10430890|PMID:10753924]
note: Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex
codon start: 1
product: elongin A
translation: MKSLQTLCEISLMRNHSNIQSVSNVPYHLLKRILQKVKIPQLLKLEKSNVLLIFDDDELWLEFLRQDFPTNVHEQFVSKRDIICKYYFDFVKENDIELYHSNQDLLKSCVRQSVVKDIRNNKYRIPYRMLYSKYQQEVEKKQEESAERLRLEMQKLQQEREKKQTIVVDHTVYFKKRNTKKTTRLHNEPHSQLYMKSLKDHESRLKHFKDGGFNIAKRHAQRVAFGGQAGGQSSSPKKGPLSIKPEPVKVNRQMDNVTAEKKDVTQPITPVKKRRSESPSIFLNRKKPALFRPTPKTNAAGSRPHTTAITNDHRTTSHPYPHKDVVTSISSVTANPVTKGHKKKKSGIFVRNAGSDGDSFPHVTATGPTTRPYIYEPRK
SIO_010081: YNL230C
subclass of: SO_0000673
so part of: YNL230C
location: complement(217523..218662)
location: region:217523-218662:-1
so has part: feature:217523-218662:-1:exon

NP_014169.1
type: Protein
SIO_000068: ncbiprotein

S000005174
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217523-218662:-1:exon

YNL229C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: URE2
locus tag: YNL229C
so part of: sequence
location: complement(<219137..>220201)
location: region:219137-220201:-1
so has part: feature:219137-220201:-1:exon
subclass of: SO_0000010

855492
type: Gene
SIO_000068: ncbigene

position:219137:-1
position: 219137
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220201:-1
position: 220201
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:219137-220201:-1:exon

YNL229C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: URE2
locus tag: YNL229C
product: glutathione peroxidase
transcript id: NM_001183067.1
SIO_010081: YNL229C
subclass of: SO_0000673
so part of: YNL229C
location: complement(<219137..>220201)
location: region:219137-220201:-1
so has part: feature:219137-220201:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:219137-220201:-1:exon

YNL229C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: URE2
locus tag: YNL229C
EC number: 1.11.1.9
experiment: EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:15371425]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10748041]
experiment: EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:10604478]
experiment: EXISTENCE:genetic interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]
experiment: EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:8002570]
experiment: EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]
experiment: EXISTENCE:mutant phenotype:GO:0042994 cytoplasmic sequestering of transcription factor [PMID:10748041|PMID:10799523]
experiment: EXISTENCE:physical interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]
note: Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression
codon start: 1
product: glutathione peroxidase
translation: MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
SIO_010081: YNL229C
subclass of: SO_0000673
so part of: YNL229C
location: complement(219137..220201)
location: region:219137-220201:-1
so has part: feature:219137-220201:-1:exon

NP_014170.1
type: Protein
SIO_000068: ncbiprotein

S000005173
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:219137-220201:-1:exon

YNL227C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: JJJ1
locus tag: YNL227C
so part of: sequence
location: complement(<220659..>222431)
location: region:220659-222431:-1
so has part: feature:220659-222431:-1:exon
subclass of: SO_0000010

855495
type: Gene
SIO_000068: ncbigene

position:220659:-1
position: 220659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222431:-1
position: 222431
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220659-222431:-1:exon

YNL227C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: JJJ1
locus tag: YNL227C
product: Jjj1p
transcript id: NM_001183065.1
SIO_010081: YNL227C
subclass of: SO_0000673
so part of: YNL227C
location: complement(<220659..>222431)
location: region:220659-222431:-1
so has part: feature:220659-222431:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220659-222431:-1:exon

YNL227C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: JJJ1
locus tag: YNL227C
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:17242366]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20368619|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17242366|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:20368619]
experiment: EXISTENCE:mutant phenotype:GO:0005730 nucleolus [PMID:20368619]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17242366]
note: Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
codon start: 1
product: Jjj1p
translation: MKTCYYELLGVETHASDLELKKAYRKKALQYHPDKNPDNVEEATQKFAVIRAAYEVLSDPQERAWYDSHKEQILNDTPPSTDDYYDYEVDATVTGVTTDELLLFFNSALYTKIDNSAAGIYQIAGKIFAKLAKDEILSGKRLGKFSEYQDDVFEQDINSIGYLKACDNFINKTDKLLYPLFGYSPTDYEYLKHFYKTWSAFNTLKSFSWKDEYMYSKNYDRRTKREVNRRNEKARQQARNEYNKTVKRFVVFIKKLDKRMKEGAKIAEEQRKLKEQQRKNELNNRRKFGNDNNDEEKFHLQSWQTVKEENWDELEKVYDNFGEFENSKNDKEGEVLIYECFICNKTFKSEKQLKNHINTKLHKKNMEEIRKEMEEENITLGLDNLSDLEKFDSADESVKEKEDIDLQALQAELAEIERKLAESSSEDESEDDNLNIEMDIEVEDVSSDENVHVNTKNKKKRKKKKKAKVDTETEESESFDDTKDKRSNELDDLLASLGDKGLQTDDDEDWSTKAKKKKGKQPKKNSKSTKSTPSLSTLPSSMSPTSAIEVCTTCGESFDSRNKLFNHVKIAGHAAVKNVVKRKKVKTKRI
SIO_010081: YNL227C
subclass of: SO_0000673
so part of: YNL227C
location: complement(220659..222431)
location: region:220659-222431:-1
so has part: feature:220659-222431:-1:exon

NP_014172.1
type: Protein
SIO_000068: ncbiprotein

S000005171
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220659-222431:-1:exon

YNL225C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CNM67
locus tag: YNL225C
so part of: sequence
location: complement(<222724..>224469)
location: region:222724-224469:-1
so has part: feature:222724-224469:-1:exon
subclass of: SO_0000010

855496
type: Gene
SIO_000068: ncbigene

position:222724:-1
position: 222724
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:224469:-1
position: 224469
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222724-224469:-1:exon

YNL225C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CNM67
locus tag: YNL225C
product: Cnm67p
transcript id: NM_001183063.1
SIO_010081: YNL225C
subclass of: SO_0000673
so part of: YNL225C
location: complement(<222724..>224469)
location: region:222724-224469:-1
so has part: feature:222724-224469:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:222724-224469:-1:exon

YNL225C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CNM67
locus tag: YNL225C
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:11514632]
experiment: EXISTENCE:direct assay:GO:0061499 outer plaque of mitotic spindle pole body [PMID:9585415]
experiment: EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:11514632]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:10749924|PMID:9571234]
experiment: EXISTENCE:mutant phenotype:GO:0051300 spindle pole body organization [PMID:9571234]
note: Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication
codon start: 1
product: Cnm67p
translation: MTDFDLMNFPFHERLDSPVSENGEIKDGEPIPQNWLNENHVGKSILPLFVNPEDVINCNFSNARDSYEENKSPSMDQMNYARNTSYQESPGLQERPKNEKDKSPIGTDVHKKDVPNFIHSTPRENSSKHFTRANEQASAQPTDEHTSPDISIEDCNGAKIFLQNSLSKEDFRMLENVILGYQKKVIELGRDNLRQEERANSLQKELEAATKSNDKTLDNKKKIEEQTVLIENLTKDLSLNKEMLEKANDTIQTKHTALLSLTDSLRKAELFEIPIGILFFDLYDSEENSSKLDHILQEKYPNIKGFLCASQQEELSRISQRFKNAKAEAEDLRNELENKKIEIQTMREKNNTLIGTNKTLSKQNKILCDKFDKLTIDEKEILKGCNEEIKIKLERLNERLGSWEKSKEKYETSLKDKEKMLADAEKKTNTLSKELDNLRSRFGNLEGNTSERITIKNILQSRPDISAEECNFLMVEQIDSANLTTLQNTVKEIVLAVGIPYPKLRRKIPLLAIKLKYENIMLSNFAQRLHRQVYSQEMNLKKFTDQAYYDFMSTRRMDSIDHHLERCLDHLYDHILEKMVK
SIO_010081: YNL225C
subclass of: SO_0000673
so part of: YNL225C
location: complement(222724..224469)
location: region:222724-224469:-1
so has part: feature:222724-224469:-1:exon

NP_014174.1
type: Protein
SIO_000068: ncbiprotein

S000005169
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:222724-224469:-1:exon

YNL224C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PFA1
gene: SQS1
locus tag: YNL224C
gene synonym: PFA1
so part of: sequence
location: complement(<224796..>227099)
location: region:224796-227099:-1
so has part: feature:224796-227099:-1:exon
subclass of: SO_0000010

855497
type: Gene
SIO_000068: ncbigene

position:224796:-1
position: 224796
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:227099:-1
position: 227099
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224796-227099:-1:exon

YNL224C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PFA1
gene: SQS1
locus tag: YNL224C
gene synonym: PFA1
product: Sqs1p
transcript id: NM_001183062.1
SIO_010081: YNL224C
subclass of: SO_0000673
so part of: YNL224C
location: complement(<224796..>227099)
location: region:224796-227099:-1
so has part: feature:224796-227099:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224796-227099:-1:exon

YNL224C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PFA1
gene: SQS1
locus tag: YNL224C
gene synonym: PFA1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:19927118]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:19927118]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16227579|PMID:19927118]
experiment: EXISTENCE:direct assay:GO:0032781 positive regulation of ATP-dependent activity [PMID:19927118]
experiment: EXISTENCE:direct assay:GO:0051096 positive regulation of helicase activity [PMID:19927118]
experiment: EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16945917]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:19927118]
experiment: EXISTENCE:genetic interaction:GO:0030490 maturation of SSU-rRNA [PMID:19801658|PMID:19927118]
experiment: EXISTENCE:mutant phenotype:GO:0032781 positive regulation of ATP-dependent activity [PMID:19927118]
experiment: EXISTENCE:mutant phenotype:GO:0051096 positive regulation of helicase activity [PMID:19927118]
note: Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
codon start: 1
product: Sqs1p
translation: MAKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPTNSWHNSSIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNRYDSSTDLQAGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENEDDDSQNSPSTDHSLSSNESKVEDGDLFFVDEEAQQSPDLTKIKRVCIEEIARPREVAIEFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSEVDQGFNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLPSPASEELEFGFKEEDFVINTNDIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVVDELGLPEDRLPAYLNFIKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHSDIEEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIETKAKKRKAKEDFIDQENRNSNDMLKKYPYGLHIQNIKDEFESFLSRNNDRLTFPPLDPHGNKTVMKIAKHYNMKSSKIGKANHTSVVVEKIKKTKWSSPNYSLIDQLMRQRPVFMRIDIRRPREEQAAFERTKTIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGLGIQGNKGISEPIFAKIKKNRSGLRHSES
SIO_010081: YNL224C
subclass of: SO_0000673
so part of: YNL224C
location: complement(224796..227099)
location: region:224796-227099:-1
so has part: feature:224796-227099:-1:exon

NP_014175.1
type: Protein
SIO_000068: ncbiprotein

S000005168
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224796-227099:-1:exon

YNL223W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG4
alternative label: AUT2
gene: ATG4
locus tag: YNL223W
gene synonym: APG4; AUT2
so part of: sequence
location: <227370..>228854
location: region:227370-228854:1
so has part: feature:227370-228854:1:exon
subclass of: SO_0000010

855498
type: Gene
SIO_000068: ncbigene

position:227370:1
position: 227370
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228854:1
position: 228854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227370-228854:1:exon

YNL223W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG4
alternative label: AUT2
gene: ATG4
locus tag: YNL223W
gene synonym: APG4; AUT2
product: cysteine protease ATG4
transcript id: NM_001183061.1
SIO_010081: YNL223W
subclass of: SO_0000673
so part of: YNL223W
location: <227370..>228854
location: region:227370-228854:1
so has part: feature:227370-228854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:227370-228854:1:exon

YNL223W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG4
alternative label: AUT2
gene: ATG4
locus tag: YNL223W
gene synonym: APG4; AUT2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22240591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22240591]
experiment: EXISTENCE:direct assay:GO:0019786 Atg8-specific peptidase activity [PMID:11038174]
experiment: EXISTENCE:direct assay:GO:0051697 protein delipidation [PMID:17632063]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:11038174]
experiment: EXISTENCE:mutant phenotype:GO:0019786 Atg8-specific peptidase activity [PMID:11038174]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:11149920]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
note: Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation
codon start: 1
product: cysteine protease ATG4
translation: MQRWLQLWKMDLVQKVSHGVFEGSSEEPAALMNHDYIVLGEVYPERDEESGAEQCEQDCRYRGEAVSDGFLSSLFGREISSYTKEFLLDVQSRVNFTYRTRFVPIARAPDGPSPLSLNLLVRTNPISTIEDYIANPDCFNTDIGWGCMIRTGQSLLGNALQILHLGRDFRVNGNESLERESKFVNWFNDTPEAPFSLHNFVSAGTELSDKRPGEWFGPAATARSIQSLIYGFPECGIDDCIVSVSSGDIYENEVEKVFAENPNSRILFLLGVKLGINAVNESYRESICGILSSTQSVGIAGGRPSSSLYFFGYQGNEFLHFDPHIPQPAVEDSFVESCHTSKFGKLQLSEMDPSMLIGILIKGEKDWQQWKLEVAESAIINVLAKRMDDFDVSCSMDDVESVSSNSMKKDASNNENLGVLEGDYVDIGAIFPHTTNTEDVDEYDCFQDIHCKKQKIVVMGNTHTVNANLTDYEVEGVLVEKETVGIHSPIDEKC
SIO_010081: YNL223W
subclass of: SO_0000673
so part of: YNL223W
location: 227370..228854
location: region:227370-228854:1
so has part: feature:227370-228854:1:exon

NP_014176.2
type: Protein
SIO_000068: ncbiprotein

S000005167
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:227370-228854:1:exon

YNL222W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSU72
locus tag: YNL222W
so part of: sequence
location: <229094..>229714
location: region:229094-229714:1
so has part: feature:229094-229714:1:exon
subclass of: SO_0000010

855499
type: Gene
SIO_000068: ncbigene

position:229094:1
position: 229094
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229714:1
position: 229714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229094-229714:1:exon

YNL222W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSU72
locus tag: YNL222W
product: RNA polymerase II subunit A C-terminal domain phosphatase
transcript id: NM_001183060.1
SIO_010081: YNL222W
subclass of: SO_0000673
so part of: YNL222W
location: <229094..>229714
location: region:229094-229714:1
so has part: feature:229094-229714:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229094-229714:1:exon

YNL222W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSU72
locus tag: YNL222W
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]
experiment: EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:12660165]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:15125841|PMID:22235117]
experiment: EXISTENCE:direct assay:GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain [PMID:15125841|PMID:22235117]
experiment: EXISTENCE:genetic interaction:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]
experiment: EXISTENCE:genetic interaction:GO:0004721 phosphoprotein phosphatase activity [PMID:12660165]
experiment: EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:11046131]
experiment: EXISTENCE:genetic interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17101794]
experiment: EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]
experiment: EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17101794]
experiment: EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12660165|PMID:22235117]
experiment: EXISTENCE:mutant phenotype:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:15125841|PMID:22235117]
experiment: EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:12660165]
experiment: EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12944462|PMID:12819204]
experiment: EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:12944462|PMID:12819204]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12704082]
experiment: EXISTENCE:mutant phenotype:GO:0031564 transcription antitermination [PMID:12453421]
experiment: EXISTENCE:mutant phenotype:GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain [PMID:15125841|PMID:22235117]
experiment: EXISTENCE:mutant phenotype:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:12704082]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:11046131]
experiment: EXISTENCE:physical interaction:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12453421]
experiment: EXISTENCE:physical interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]
note: Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
codon start: 1
product: RNA polymerase II subunit A C-terminal domain phosphatase
translation: MPSHRNSNLKFCTVCASNNNRSMESHKVLQEAGYNVSSYGTGSAVRLPGLSIDKPNVYSFGTPYNDIYNDLLSQSADRYKSNGLLQMLDRNRRLKKAPEKWQESTKVFDFVFTCEERCFDAVCEDLMNRGGKLNKIVHVINVDIKDDDENAKIGSKAILELADMLNDKIEQCEKDDIPFEDCIMDILTEWQSSHSQLPSLYAPSYY
SIO_010081: YNL222W
subclass of: SO_0000673
so part of: YNL222W
location: 229094..229714
location: region:229094-229714:1
so has part: feature:229094-229714:1:exon

NP_014177.1
type: Protein
SIO_000068: ncbiprotein

S000005166
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229094-229714:1:exon

YNCN0005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR19
locus tag: YNCN0005C
so part of: sequence
location: complement(230105..230672)
location: region:230105-230672:-1
so has part: feature:230105-230672:-1:exon
subclass of: SO_0000623

9164965
type: Gene
SIO_000068: ncbigene

position:230105:-1
position: 230105
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:230672:-1
position: 230672
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:230105-230672:-1:exon

YNCN0005C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snRNA
gene: SNR19
locus tag: YNCN0005C
product: SNR19
experiment: EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:2529976]
experiment: EXISTENCE:direct assay:GO:0000395 mRNA 5'-splice site recognition [PMID:18084028]
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:2440584]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:2440584]
experiment: EXISTENCE:direct assay:GO:0030627 pre-mRNA 5'-splice site binding [PMID:12214237|PMID:18084028]
experiment: EXISTENCE:mutant phenotype:GO:0030627 pre-mRNA 5'-splice site binding [PMID:15989965|PMID:3056718]
note: U1 spliceosomal RNA (U1 snRNA); snRNA U1 homolog
transcript id: NR_132250.1
SIO_010081: YNCN0005C
subclass of: SO_0000673
so part of: YNCN0005C
location: complement(230105..230672)
location: region:230105-230672:-1
so has part: feature:230105-230672:-1:exon

S000007295
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:230105-230672:-1:exon

YNL221C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POP1
locus tag: YNL221C
so part of: sequence
location: complement(<231068..>233695)
location: region:231068-233695:-1
so has part: feature:231068-233695:-1:exon
subclass of: SO_0000010

855500
type: Gene
SIO_000068: ncbigene

position:231068:-1
position: 231068
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233695:-1
position: 233695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231068-233695:-1:exon

YNL221C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POP1
locus tag: YNL221C
product: ribonuclease P/MRP protein subunit POP1
transcript id: NM_001183059.1
SIO_010081: YNL221C
subclass of: SO_0000673
so part of: YNL221C
location: complement(<231068..>233695)
location: region:231068-233695:-1
so has part: feature:231068-233695:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:231068-233695:-1:exon

YNL221C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POP1
locus tag: YNL221C
EC number: 3.1.26.5
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [PMID:14729943]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23700311|PMID:26135751]
experiment: EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]
experiment: EXISTENCE:direct assay:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
experiment: EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:16618965]
experiment: EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:16618965]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:7926742]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:7926742]
experiment: EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]
note: Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P
codon start: 1
product: ribonuclease P/MRP protein subunit POP1
translation: MSGSLSRGNGGKKVLNKNQLLKRNRIRNARSIRAEAVAASSTKTGTPSDLSESGSKLNVDQFISSRQFEVKQLQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREMRKSDQQDVLKGSSASSRKAHGLNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNCHVRQKIKTLKRMIKESSTANPNIKLLNNRMGSYDCTGVNELAPIPKGRVKYTKRQKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLGGDTCSSDGALCMDSSYIGTIIVKDKSNDSEGDFLKSIIGKLTAERANLRKYREGQVLFQGLIYSFNEENGEDSTKPLGPCDVFWVQKDTAIIRLHPSIYTQVFNILLQHKEKLTVQDCRYSLASVTLKGAKALESLASCLRSTEYSKSFEQFKMVSMITDHNALPQRCTFAFEAIDPRHLAAPKKLNDSQRKTVNSDDILSLHENYPQDEINAVFNELCDPESRTQSYNNQNTLKEISARRYKLLTATPNSINKTTVPFKESDDPSIPLVIIRRLKTRDWIVVLPWFWLLPLWHLLNRIPRMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEASKTKWDRKPMGKRINFEKIKDIHNTKLPAYSGEIGDFFSSDWRFLQILRNGIDYLQRNDKTLELMDSKKTGQFNAQGVRDINCVNDVLEFCKDYEAKTKAMSLSIEENIPVALCKNRKCQFRTPDSISVNSSSFSLTFFPRCIIAVSCTLLERGHPKDNARIYQVPEKDLEHWLQLAKGVYRPNGRKDHDLKIPLPEVHDLIGFITSGTYHLNCGNGMGIGFIDHHAAIRQPTRYVLIRNVGTNTYRLGEWSKISV
SIO_010081: YNL221C
subclass of: SO_0000673
so part of: YNL221C
location: complement(231068..233695)
location: region:231068-233695:-1
so has part: feature:231068-233695:-1:exon

NP_014178.1
type: Protein
SIO_000068: ncbiprotein

S000005165
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:231068-233695:-1:exon

YNL220W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BRA9
gene: ADE12
locus tag: YNL220W
gene synonym: BRA9
so part of: sequence
location: <234413..>235714
location: region:234413-235714:1
so has part: feature:234413-235714:1:exon
subclass of: SO_0000010

855501
type: Gene
SIO_000068: ncbigene

position:234413:1
position: 234413
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235714:1
position: 235714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234413-235714:1:exon

YNL220W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BRA9
gene: ADE12
locus tag: YNL220W
gene synonym: BRA9
product: adenylosuccinate synthase
transcript id: NM_001183058.1
SIO_010081: YNL220W
subclass of: SO_0000673
so part of: YNL220W
location: <234413..>235714
location: region:234413-235714:1
so has part: feature:234413-235714:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234413-235714:1:exon

YNL220W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BRA9
gene: ADE12
locus tag: YNL220W
gene synonym: BRA9
EC number: 6.3.4.4
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:8706758]
experiment: EXISTENCE:direct assay:GO:0004019 adenylosuccinate synthase activity [PMID:8706758|PMID:10417315]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004019 adenylosuccinate synthase activity [PMID:5807803]
experiment: EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:5807803]
note: Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
codon start: 1
product: adenylosuccinate synthase
translation: MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKEIK
SIO_010081: YNL220W
subclass of: SO_0000673
so part of: YNL220W
location: 234413..235714
location: region:234413-235714:1
so has part: feature:234413-235714:1:exon

NP_014179.1
type: Protein
SIO_000068: ncbiprotein

S000005164
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234413-235714:1:exon

YNL219C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALG9
locus tag: YNL219C
so part of: sequence
location: complement(<235996..>237663)
location: region:235996-237663:-1
so has part: feature:235996-237663:-1:exon
subclass of: SO_0000010

855502
type: Gene
SIO_000068: ncbigene

position:235996:-1
position: 235996
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237663:-1
position: 237663
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:235996-237663:-1:exon

YNL219C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALG9
locus tag: YNL219C
product: dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
transcript id: NM_001183057.1
SIO_010081: YNL219C
subclass of: SO_0000673
so part of: YNL219C
location: complement(<235996..>237663)
location: region:235996-237663:-1
so has part: feature:235996-237663:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:235996-237663:-1:exon

YNL219C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALG9
locus tag: YNL219C
EC number: 2.4.1.259
EC number: 2.4.1.261
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:15987956]
experiment: EXISTENCE:direct assay:GO:0052918 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]
experiment: EXISTENCE:direct assay:GO:0052926 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]
experiment: EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:8692962]
experiment: EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8692962]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8692962]
experiment: EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:15987956]
note: Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation
codon start: 1
product: dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase
translation: MNCKAVTISLLLLLFLTRVYIQPTFSLISDCDETFNYWEPLNLLVRGFGKQTWEYSPEYSIRSWAFLLPFYCILYPVNKFTDLESHWNFFITRACLGFFSFIMEFKLHREIAGSLALQIANIWIIFQLFNPGWFHASVELLPSAVAMLLYVGATRHSLRYLSTGSTSNFTKSLAYNFLASILGWPFVLILSLPLCLHYLFNHRIISTIRTAFDCCLIFSLTAFAVIVTDSIFYGKLAPVSWNILFYNVINASEESGPNIFGVEPWYYYPLNLLLNFPLPVLVLAILGIFHLRLWPLWASLFTWIAVFTQQPHKEERFLYPIYGLITLSASIAFYKVLNLFNRKPILKKGIKLSVLLIVAGQAMSRIVALVNNYTAPIAVYEQFSSLNQGGVKAPVVNVCTGREWYHFPSSFLLPDNHRLKFVKSGFDGLLPGDFPESGSIFKKIRTLPKGMNNKNIYDTGKEWPITRCDYFIDIVAPINLTKDVFNPLHLMDNWNKLACAAFIDGENSKILGRAFYVPEPINRIMQIVLPKQWNQVYGVRYIDYCLFEKPTETTN
SIO_010081: YNL219C
subclass of: SO_0000673
so part of: YNL219C
location: complement(235996..237663)
location: region:235996-237663:-1
so has part: feature:235996-237663:-1:exon

NP_014180.1
type: Protein
SIO_000068: ncbiprotein

S000005163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:235996-237663:-1:exon

YNL218W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MGS1
locus tag: YNL218W
so part of: sequence
location: <238238..>240001
location: region:238238-240001:1
so has part: feature:238238-240001:1:exon
subclass of: SO_0000010

855503
type: Gene
SIO_000068: ncbigene

position:238238:1
position: 238238
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:240001:1
position: 240001
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:238238-240001:1:exon

YNL218W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MGS1
locus tag: YNL218W
product: ssDNA-dependent ATPase MGS1
transcript id: NM_001183056.1
SIO_010081: YNL218W
subclass of: SO_0000673
so part of: YNL218W
location: <238238..>240001
location: region:238238-240001:1
so has part: feature:238238-240001:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:238238-240001:1:exon

YNL218W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MGS1
locus tag: YNL218W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16251400]
experiment: EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:11459965|PMID:16251400]
experiment: EXISTENCE:direct assay:GO:0033567 DNA replication, Okazaki fragment processing [PMID:16251400]
experiment: EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:32748509]
experiment: EXISTENCE:direct assay:GO:1905493 regulation of G-quadruplex DNA binding [PMID:32748509]
experiment: EXISTENCE:genetic interaction:GO:0006282 regulation of DNA repair [PMID:16809783]
experiment: EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:32748509]
note: Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
codon start: 1
product: ssDNA-dependent ATPase MGS1
translation: MSNKRTSVEQLISCPICSRKVFFSLINSHLDICGKEKSKPSSRPQTVSSLLAGPKKRKQANSEKFIDLENKDHEIKPGLKSESDDIEIVENESKRFKAAPSTDFAKSIVEPASSRDQLHNDYESRWLQKISHLPLSEKLRPKELRDYVGQQHILSQDNGTLFKYIKQGTIPSMILWGPPGVGKTSLARLLTKTATTSSNESNVGSRYFMIETSATKANTQELRGIFEKSKKEYQLTKRRTVLFIDEIHRFNKVQQDLLLPHVENGDIILIGATTENPSFQLNNALISRCLIFVLEKLNVNELCIVLSRGIALLNKCRKQVWNIENPLKLSRSILEYVVDLSVGDTRRALNMLEMIEVSTRERKADEEELSIDDVRDIIKNNSSNGLNTYYDPKGDNHYDTISAFHKSIRGGDENASLYYLARMLQGGEDPLYVARRMIRIASEDIGLRDSSLLPLAVAAHDAVMKVGLPEADLALAQCCVALARAPKSVELYRAWKKLRAMMSENMYSLASSEIPMHIRNAPTKLMEELGYHKGYKYNPDYIEGKVQQDYFPKEVLEKCPNKTDLKFLDGKHLGDKEDPDLRQSYQG
SIO_010081: YNL218W
subclass of: SO_0000673
so part of: YNL218W
location: 238238..240001
location: region:238238-240001:1
so has part: feature:238238-240001:1:exon

NP_014181.1
type: Protein
SIO_000068: ncbiprotein

S000005162
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:238238-240001:1:exon

YNL217W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPN2
locus tag: YNL217W
so part of: sequence
location: <240331..>241311
location: region:240331-241311:1
so has part: feature:240331-241311:1:exon
subclass of: SO_0000010

855504
type: Gene
SIO_000068: ncbigene

position:240331:1
position: 240331
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241311:1
position: 241311
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:240331-241311:1:exon

YNL217W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPN2
locus tag: YNL217W
product: putative serine/threonine-protein phosphatase
transcript id: NM_001183055.1
SIO_010081: YNL217W
subclass of: SO_0000673
so part of: YNL217W
location: <240331..>241311
location: region:240331-241311:1
so has part: feature:240331-241311:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:240331-241311:1:exon

YNL217W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPN2
locus tag: YNL217W
experiment: EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:31175919|PMID:28302909]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005775 vacuolar lumen [PMID:28302909]
experiment: EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:28302909]
experiment: EXISTENCE:genetic interaction:GO:0000298 endopolyphosphatase activity [PMID:28302909]
experiment: EXISTENCE:genetic interaction:GO:0006798 polyphosphate catabolic process [PMID:28302909]
experiment: EXISTENCE:mutant phenotype:GO:0000298 endopolyphosphatase activity [PMID:28302909]
experiment: EXISTENCE:mutant phenotype:GO:0006798 polyphosphate catabolic process [PMID:28302909]
note: Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
codon start: 1
product: putative serine/threonine-protein phosphatase
translation: MEDKRKRRAATLSTALILFVACCVYTLYIFKFDNPRLSPPVSLLPTISTLKKIEHVTDLNKEYVFVGDVHGNYDEFIELIDDKIGGLGENITMILLGDFIHKGPDSDKVVSYILNHKDQVKCVLGNHEILVMMAYLNPDFSKWVRRPKLMTPLTFSTETNFIPQDISKISNAHGRLARELGFSKLSQLAEHCSMAIELDLDITGDILFGAHAGMVPGDFMKPNQIPGVSSLSNMKYVDKKNWSKTSREKENKNYVRWYTLWDKYGDHFSNAKVFYGHDASMGLNLRRQTKGLDTACIKNNLLSSMKVKYDIKKGQYDYELIQVQCS
SIO_010081: YNL217W
subclass of: SO_0000673
so part of: YNL217W
location: 240331..241311
location: region:240331-241311:1
so has part: feature:240331-241311:1:exon

NP_014182.1
type: Protein
SIO_000068: ncbiprotein

S000005161
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:240331-241311:1:exon

YNL216W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GRC4
alternative label: GRF1
alternative label: TBA1
alternative label: TUF1
gene: RAP1
locus tag: YNL216W
gene synonym: GRC4; GRF1; TBA1; TUF1
so part of: sequence
location: <241689..>244172
location: region:241689-244172:1
so has part: feature:241689-244172:1:exon
subclass of: SO_0000010

855505
type: Gene
SIO_000068: ncbigene

position:241689:1
position: 241689
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:244172:1
position: 244172
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241689-244172:1:exon

YNL216W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GRC4
alternative label: GRF1
alternative label: TBA1
alternative label: TUF1
gene: RAP1
locus tag: YNL216W
gene synonym: GRC4; GRF1; TBA1; TUF1
product: DNA-binding transcription factor RAP1
transcript id: NM_001183054.1
SIO_010081: YNL216W
subclass of: SO_0000673
so part of: YNL216W
location: <241689..>244172
location: region:241689-244172:1
so has part: feature:241689-244172:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241689-244172:1:exon

YNL216W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GRC4
alternative label: GRF1
alternative label: TBA1
alternative label: TUF1
gene: RAP1
locus tag: YNL216W
gene synonym: GRC4; GRF1; TBA1; TUF1
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11455386]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:16956377|PMID:26399229|PMID:9710643]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1904543]
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:12051841|PMID:10487921]
experiment: EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:17074814]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:18195009|PMID:20559389]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2656680]
experiment: EXISTENCE:direct assay:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]
experiment: EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:18195009]
experiment: EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:19782036]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:8510148|PMID:17656141|PMID:2225074]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:31742863]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:8194531]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20559389]
experiment: EXISTENCE:direct assay:GO:0061849 telomeric G-quadruplex DNA binding [PMID:8052638]
experiment: EXISTENCE:direct assay:GO:0070187 shelterin complex [PMID:23746845]
experiment: EXISTENCE:direct assay:GO:0071919 G-quadruplex DNA formation [PMID:8052638]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:7958893]
experiment: EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7958893]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15300680]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:2010087]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:2237406]
experiment: EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]
experiment: EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]
experiment: EXISTENCE:mutant phenotype:GO:0031848 protection from non-homologous end joining at telomere [PMID:16096640]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2010087]
experiment: EXISTENCE:physical interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:12080091]
experiment: EXISTENCE:physical interaction:GO:0070200 establishment of protein localization to telomere [PMID:11689698]
experiment: EXISTENCE:physical interaction:GO:0071169 establishment of protein localization to chromatin [PMID:11689698]
note: Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters
codon start: 1
product: DNA-binding transcription factor RAP1
translation: MSSPDDFETAPAEYVDALDPSMVVVDSGSAAVTAPSDSAAEVKANQNEENTGATAAETSEKVDQTEVEKKDDDDTTEVGVTTTTPSIADTAATANIASTSGASVTEPTTDDTAADEKKEQVSGPPLSNMKFYLNRDADAHDSLNDIDQLARLIRANGGEVLDSKPRESKENVFIVSPYNHTNLPTVTPTYIKACCQSNSLLNMENYLVPYDNFREVVDSRLQEESHSNGVDNSNSNSDNKDSIRPKTEIISTNTNGATEDSTSEKVMVDAEQQARLQEQAQLLRQHVSSTASITSGGHNDLVQIEQPQKDTSNNNNSNVNDEDNDLLTQDNNPQTADEGNASFQAQRSMISRGALPSHNKASFTDEEDEFILDVVRKNPTRRTTHTLYDEISHYVPNHTGNSIRHRFRVYLSKRLEYVYEVDKFGKLVRDDDGNLIKTKVLPPSIKRKFSADEDYTLAIAVKKQFYRDLFQIDPDTGRSLITDEDTPTAIARRNMTMDPNHVPGSEPNFAAYRTQSRRGPIAREFFKHFAEEHAAHTENAWRDRFRKFLLAYGIDDYISYYEAEKAQNREPEPMKNLTNRPKRPGVPTPGNYNSAAKRARNYSSQRNVQPTANAASANAAAAAAAAASNSYAIPENELLDEDTMNFISSLKNDLSNISNSLPFEYPHEIAEAIRSDFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEKDLL
SIO_010081: YNL216W
subclass of: SO_0000673
so part of: YNL216W
location: 241689..244172
location: region:241689-244172:1
so has part: feature:241689-244172:1:exon

NP_014183.1
type: Protein
SIO_000068: ncbiprotein

S000005160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241689-244172:1:exon

YNL215W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IES2
locus tag: YNL215W
so part of: sequence
location: <244468..>245430
location: region:244468-245430:1
so has part: feature:244468-245430:1:exon
subclass of: SO_0000010

855506
type: Gene
SIO_000068: ncbigene

position:244468:1
position: 244468
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245430:1
position: 245430
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:244468-245430:1:exon

YNL215W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IES2
locus tag: YNL215W
product: Ies2p
transcript id: NM_001183053.1
SIO_010081: YNL215W
subclass of: SO_0000673
so part of: YNL215W
location: <244468..>245430
location: region:244468-245430:1
so has part: feature:244468-245430:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:244468-245430:1:exon

YNL215W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IES2
locus tag: YNL215W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
codon start: 1
product: Ies2p
translation: MDSEASDIEAELSDSVSAGGEEYIDDDDYTEDIDDQIVTAKSSRRTARRSVPKGVRTSKRIRDKELSVEVDEDYDEEEDVLSPSKKRHLHTRSMDKRQVAATASEKSDIGDSKGNDGEIEDGILEEEESLEKELNRGGGKEVEKSEESYYAQNDVGQKGEEEQDGESGGYEDNEPSISKESDELVSVVNGNGNEEDDEVEATKENTTDSTRSTTTRSKMLLDLLEDGGSKKKLTDEEIQLRRAENARKRKNLSEKRLEEEKQDTINKLLKKRAGKSRSHLPNDDEKNDGSSSFVKPRRPYNSEGMTRILRRYEEDLFCTF
SIO_010081: YNL215W
subclass of: SO_0000673
so part of: YNL215W
location: 244468..245430
location: region:244468-245430:1
so has part: feature:244468-245430:1:exon

NP_014184.1
type: Protein
SIO_000068: ncbiprotein

S000005159
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:244468-245430:1:exon

YNL214W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS9
gene: PEX17
locus tag: YNL214W
gene synonym: PAS9
so part of: sequence
location: <245617..>246216
location: region:245617-246216:1
so has part: feature:245617-246216:1:exon
subclass of: SO_0000010

855507
type: Gene
SIO_000068: ncbigene

position:245617:1
position: 245617
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246216:1
position: 246216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245617-246216:1:exon

YNL214W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS9
gene: PEX17
locus tag: YNL214W
gene synonym: PAS9
product: Pex17p
transcript id: NM_001183052.1
SIO_010081: YNL214W
subclass of: SO_0000673
so part of: YNL214W
location: <245617..>246216
location: region:245617-246216:1
so has part: feature:245617-246216:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245617-246216:1:exon

YNL214W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS9
gene: PEX17
locus tag: YNL214W
gene synonym: PAS9
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9425153]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831|PMID:12667447]
experiment: EXISTENCE:mutant phenotype:GO:0005778 peroxisomal membrane [PMID:9425153]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12667447|PMID:16679311|PMID:9425153]
experiment: EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:16679311]
note: Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
codon start: 1
product: Pex17p
translation: MTSINSFPRNIDWPSNIGIKKIEGTNPTVNAIKGLLYNGGSIYAFLYFVIAMFVEPTLQKQYQQRNDFSLFVLLRLRRIIAQLQKRLVMTPVSSLGFNEQNNFVERSTQTSDDNIIREDNSHWAEMIYQLQNMKQELQYFNRSSGQPSESIDDFVFQIKMVTDQVELTDRSRAFSNKSRNIIQGIREIKGWFVNGQVPR
SIO_010081: YNL214W
subclass of: SO_0000673
so part of: YNL214W
location: 245617..246216
location: region:245617-246216:1
so has part: feature:245617-246216:1:exon

NP_014185.1
type: Protein
SIO_000068: ncbiprotein

S000005158
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245617-246216:1:exon

YNL213C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRG9
locus tag: YNL213C
so part of: sequence
location: complement(<246460..>247104)
location: region:246460-247104:-1
so has part: feature:246460-247104:-1:exon
subclass of: SO_0000010

855508
type: Gene
SIO_000068: ncbigene

position:246460:-1
position: 246460
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:247104:-1
position: 247104
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246460-247104:-1:exon

YNL213C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRG9
locus tag: YNL213C
product: Rrg9p
transcript id: NM_001183051.1
SIO_010081: YNL213C
subclass of: SO_0000673
so part of: YNL213C
location: complement(<246460..>247104)
location: region:246460-247104:-1
so has part: feature:246460-247104:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246460-247104:-1:exon

YNL213C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRG9
locus tag: YNL213C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10029995]
note: hypothetical protein; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Rrg9p
translation: MNILRIACRSFHCLRCGPLLNENRGWSSKKIIKLVNKSSLSNKEFTEKVRDGTKDIPEWKKQKMAVRKKLQGQRWNPPKKISQEQMEALRLLKFNFPELTASDLADRFKISPEAVRRILKSNWKRTDEENNNTYERWKRRGERIKEMYQRKEDADFVSNQIVTSRKIILGSNSNSPELIARNVRTFKPFKPNNSTPEKKNTNKLYILKHLGSKQ
SIO_010081: YNL213C
subclass of: SO_0000673
so part of: YNL213C
location: complement(246460..247104)
location: region:246460-247104:-1
so has part: feature:246460-247104:-1:exon

NP_014186.1
type: Protein
SIO_000068: ncbiprotein

S000005157
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246460-247104:-1:exon

YNL212W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VID27
locus tag: YNL212W
so part of: sequence
location: <247461..>249809
location: region:247461-249809:1
so has part: feature:247461-249809:1:exon
subclass of: SO_0000010

855509
type: Gene
SIO_000068: ncbigene

position:247461:1
position: 247461
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:249809:1
position: 249809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:247461-249809:1:exon

YNL212W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VID27
locus tag: YNL212W
product: Vid27p
transcript id: NM_001183050.1
SIO_010081: YNL212W
subclass of: SO_0000673
so part of: YNL212W
location: <247461..>249809
location: region:247461-249809:1
so has part: feature:247461-249809:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:247461-249809:1:exon

YNL212W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VID27
locus tag: YNL212W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Cytoplasmic hypothetical protein; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains
codon start: 1
product: Vid27p
translation: MNILKKFMESGNKPELITIPSGQFNLLRSKNSPKAALECIYNNATLSVRKIGKFDYELAVYRVEDDSEGGTGDEAENFEDDTISVLSTQSKKKEEEWSVEISDKIMFHKTWDKQGNVALVWENLRGDEQDEKVQFVVAADVSFSDVEQFIQTVYRCQFEVRNKKSSLTASADDLKEIEHRSTRLFVQDDDDELDSSSDDFQDAKDTSFEHEKESEILERTPSPLKKVPEGEYCCLVMSSLYMYDPIQEKFILQEPVVKVAIIDTGKYEFWLAIEGKDNRLGTQVAPNINPTFELATDAFLFNYTLQNITLSYMLKFKDLDKCIQFRFAWVKCLWMTLNKETWTDVPEKEKDYILDSSSVPLEKQFDDILHIDDRSNEERDKESSESENDSEDEDDENDHSKRIISSEAFEEPRRATSKGNSSLTVAFRNNRSYVTRDNRIGVFKTDDEDDSLEFVAAIKNISNLGGKSIDPHKPMLYMEDRNLILTDGENENKLYKMDIERGKVIEEWSTGDKNVVQYGPTKKFDQMTPEQTIVGVSQKGVFKIDPRINGKNKIAVDESKDYVGKYNFSSIGTTESGYIAIGSEKGDIKLYDRLGIRAKTAIPSLGQAIKFITTSADGKWLLATCESTLLLMDLKIKDGKNAGNIGFLKSFPASENVKTYVLKIRPEHSASILTYTKKPIRFTKAYFNTGIGQQEQTIVTSTGPYAISWSLKGILNQDGSNNYPYRIRRYNADVVADNFEFGSDKKVIVALKDDVSLSKVKSFKQPSKGVLMPSASLQDFYG
SIO_010081: YNL212W
subclass of: SO_0000673
so part of: YNL212W
location: 247461..249809
location: region:247461-249809:1
so has part: feature:247461-249809:1:exon

NP_014187.1
type: Protein
SIO_000068: ncbiprotein

S000005156
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:247461-249809:1:exon

YNL211C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRX7
locus tag: YNL211C
so part of: sequence
location: complement(<250055..>250315)
location: region:250055-250315:-1
so has part: feature:250055-250315:-1:exon
subclass of: SO_0000010

855510
type: Gene
SIO_000068: ncbigene

position:250055:-1
position: 250055
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:250315:-1
position: 250315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:250055-250315:-1:exon

YNL211C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRX7
locus tag: YNL211C
product: Mrx7p
transcript id: NM_001183049.1
SIO_010081: YNL211C
subclass of: SO_0000673
so part of: YNL211C
location: complement(<250055..>250315)
location: region:250055-250315:-1
so has part: feature:250055-250315:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:250055-250315:-1:exon

YNL211C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRX7
locus tag: YNL211C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
codon start: 1
product: Mrx7p
translation: MPPRSIEEWFYYKLLSSPGFHRFVRKVYRKVNGIKEDPFTDQSTAFQYLYKPTPRQKFKALRLLFWDEMRSTFGFRRRLGDRFKKD
SIO_010081: YNL211C
subclass of: SO_0000673
so part of: YNL211C
location: complement(250055..250315)
location: region:250055-250315:-1
so has part: feature:250055-250315:-1:exon

NP_014188.1
type: Protein
SIO_000068: ncbiprotein

S000005155
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:250055-250315:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1413; Strong origin of replication activated in late S phase
so part of: sequence
location: 250315..250931
location: region:250315-250931:1
so has part: feature:250315-250931:1:region

S000077375
type: SGD
SIO_000068: sgd

position:250315:1
position: 250315
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:250931:1
position: 250931
reference: sequence
type: ForwardStrandPosition
type: ExactPosition
type: FuzzyPosition

urn:…
SIO_000300: 1
SIO_000628: feature:250315-250931:1:region

YNL210W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MER1
locus tag: YNL210W
so part of: sequence
location: <250931..>251743
location: region:250931-251743:1
so has part: feature:250931-251743:1:exon
subclass of: SO_0000010

855511
type: Gene
SIO_000068: ncbigene

position:251743:1
position: 251743
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:250931-251743:1:exon

YNL210W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MER1
locus tag: YNL210W
product: Mer1p
transcript id: NM_001183048.1
SIO_010081: YNL210W
subclass of: SO_0000673
so part of: YNL210W
location: <250931..>251743
location: region:250931-251743:1
so has part: feature:250931-251743:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:250931-251743:1:exon

YNL210W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MER1
locus tag: YNL210W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:10983980]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7891689]
experiment: EXISTENCE:direct assay:GO:1990446 U1 snRNP binding [PMID:10983980]
experiment: EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:2659434]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2659434]
experiment: EXISTENCE:mutant phenotype:GO:0048026 positive regulation of mRNA splicing, via spliceosome [PMID:10983980]
note: mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22
codon start: 1
product: Mer1p
translation: MSNQHSPQPFCLDTKLVKLLEELQEGKQFNNKNIFPEKALYLKLALDYSFFRKNLLEFCVHLDKIKGVIRPNYDTIYILCLLEVDLLNLVFTDNILEICLPRFVSREDLRVFNNTFYTYHDNRLRILQEDFSQLFKKIKTKASVLCFTVEEIFLTNQEILPQNSTVAELQKSTNKVQTNGPQRHDFIVTLEIKLNKTQITFLIGAKGTRIESLREKSGASIKIIPISDKMTAHERNHPESVQQTILISGDLYSIALAVTSIESALITLDL
SIO_010081: YNL210W
subclass of: SO_0000673
so part of: YNL210W
location: 250931..251743
location: region:250931-251743:1
so has part: feature:250931-251743:1:exon

NP_014189.1
type: Protein
SIO_000068: ncbiprotein

S000005154
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:250931-251743:1:exon

YNL209W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YG103
gene: SSB2
locus tag: YNL209W
gene synonym: YG103
so part of: sequence
location: <252059..>253900
location: region:252059-253900:1
so has part: feature:252059-253900:1:exon
subclass of: SO_0000010

855512
type: Gene
SIO_000068: ncbigene

position:252059:1
position: 252059
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253900:1
position: 253900
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:252059-253900:1:exon

YNL209W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YG103
gene: SSB2
locus tag: YNL209W
gene synonym: YG103
product: Hsp70 family ATPase SSB2
transcript id: NM_001183047.1
SIO_010081: YNL209W
subclass of: SO_0000673
so part of: YNL209W
location: <252059..>253900
location: region:252059-253900:1
so has part: feature:252059-253900:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:252059-253900:1:exon

YNL209W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YG103
gene: SSB2
locus tag: YNL209W
gene synonym: YG103
EC number: 3.6.4.10
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:1394434|PMID:16413483]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9860955]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9670014]
experiment: EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:9670014]
experiment: EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:20368619]
experiment: EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:19723765]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1394434]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]
experiment: EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]
experiment: EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:1394434]
note: Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
codon start: 1
product: Hsp70 family ATPase SSB2
translation: MAEGVFQGAIGIDLGTTYSCVATYESSVEIIANEQGNRVTPSFVAFTPQERLIGDAAKNQAALNPRNTVFDAKRLIGRRFDDESVQKDMKTWPFKVIDVDGNPVIEVQYLEETKTFSPQEISAMVLTKMKEIAEAKIGKKVEKAVITVPAYFNDAQRQATKDAGAISGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLHIAGGVYTVKSTSGNTHLGGQDFDTNLLEHFKAEFKKKTGLDISDDARALRRLRTAAERAKRTLSSVTQTTVEVDSLFDGEDFESSLTRARFEDLNAALFKSTLEPVEQVLKDAKISKSQIDEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTSDETKDLLLLDVAPLSLGVGMQGDIFGIVVPRNTTVPTIKRRTFTTVSDNQTTVQFPVYQGERVNCKENTLLGEFDLKNIPMMPAGEPVLEAIFEVDANGILKVTAVEKSTGKSSNITISNAVGRLSSEEIEKMVNQAEEFKAADEAFAKKHEARQRLESYVASIEQTVTDPVLSSKLKRGSKSKIEAALSDALAALQIEDPSADELRKAEVGLKRVVTKAMSSR
SIO_010081: YNL209W
subclass of: SO_0000673
so part of: YNL209W
location: 252059..253900
location: region:252059-253900:1
so has part: feature:252059-253900:1:exon

NP_014190.1
type: Protein
SIO_000068: ncbiprotein

S000005153
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:252059-253900:1:exon

YNL208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL208W
so part of: sequence
location: <254418..>255017
location: region:254418-255017:1
so has part: feature:254418-255017:1:exon
subclass of: SO_0000010

855513
type: Gene
SIO_000068: ncbigene

position:254418:1
position: 254418
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255017:1
position: 255017
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:254418-255017:1:exon

YNL208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL208W
product: uncharacterized protein
transcript id: NM_001183046.1
SIO_010081: YNL208W
subclass of: SO_0000673
so part of: YNL208W
location: <254418..>255017
location: region:254418-255017:1
so has part: feature:254418-255017:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:254418-255017:1:exon

YNL208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL208W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
codon start: 1
product: uncharacterized protein
translation: MSANEFYSSGQQGQYNQQNNQERTGAPNNGQYGADNGNPNGERGLFSTIVGGSAGAYAGSKVSNNHSKLSGVLGAIGGAFLANKISDERKEHKQQEQYGNSNFGGAPQGGHNNHHRQDNNNNNGGFGGPGGPGGQGFGRQGPQGFGGPGPQEFGGPGGQGFGGPNPQEFGGPGGQGFGGPNPQEFGGQGRQGFNGGSRW
SIO_010081: YNL208W
subclass of: SO_0000673
so part of: YNL208W
location: 254418..255017
location: region:254418-255017:1
so has part: feature:254418-255017:1:exon

NP_014191.2
type: Protein
SIO_000068: ncbiprotein

S000005152
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:254418-255017:1:exon

YNL207W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIO2
locus tag: YNL207W
so part of: sequence
location: <255353..>256630
location: region:255353-256630:1
so has part: feature:255353-256630:1:exon
subclass of: SO_0000010

855514
type: Gene
SIO_000068: ncbigene

position:255353:1
position: 255353
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256630:1
position: 256630
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255353-256630:1:exon

YNL207W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIO2
locus tag: YNL207W
product: protein kinase RIO2
transcript id: NM_001183045.1
SIO_010081: YNL207W
subclass of: SO_0000673
so part of: YNL207W
location: <255353..>256630
location: region:255353-256630:1
so has part: feature:255353-256630:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255353-256630:1:exon

YNL207W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIO2
locus tag: YNL207W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:12690111]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12690111|PMID:12612080]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15167894]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12612080]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12690111|PMID:12612080|PMID:15167894]
experiment: EXISTENCE:mutant phenotype:GO:0046830 positive regulation of RNA import into nucleus [PMID:12612080]
note: Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
codon start: 1
product: protein kinase RIO2
translation: MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSNDEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLGNYILE
SIO_010081: YNL207W
subclass of: SO_0000673
so part of: YNL207W
location: 255353..256630
location: region:255353-256630:1
so has part: feature:255353-256630:1:exon

NP_014192.1
type: Protein
SIO_000068: ncbiprotein

S000005151
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255353-256630:1:exon

YNL206C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTT106
locus tag: YNL206C
so part of: sequence
location: complement(<256788..>258155)
location: region:256788-258155:-1
so has part: feature:256788-258155:-1:exon
subclass of: SO_0000010

855515
type: Gene
SIO_000068: ncbigene

position:256788:-1
position: 256788
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:258155:-1
position: 258155
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256788-258155:-1:exon

YNL206C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTT106
locus tag: YNL206C
product: Rtt106p
transcript id: NM_001183044.1
SIO_010081: YNL206C
subclass of: SO_0000673
so part of: YNL206C
location: complement(<256788..>258155)
location: region:256788-258155:-1
so has part: feature:256788-258155:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256788-258155:-1:exon

YNL206C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTT106
locus tag: YNL206C
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:20007951]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16157874|PMID:18662540|PMID:20007951]
experiment: EXISTENCE:genetic interaction:GO:0006335 DNA replication-dependent chromatin assembly [PMID:18662540]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:18708354]
experiment: EXISTENCE:genetic interaction:GO:0031507 heterochromatin formation [PMID:17410207|PMID:20007951]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19683497]
experiment: EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:20007951]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:18708354]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:18708354]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:17410207]
experiment: EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:20007951]
experiment: EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:16157874]
note: Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)
codon start: 1
product: Rtt106p
translation: MSKLFLDELPESLSRKIGTVVRVLPSSLEIFEELYKYALNENSNDRSGRHKKPRIDVSSDLLKTDEISETNTIFKLEGVSVLSPLRKKLDLVFYLSNVDGSPVITLLKGNDRELSIYQLNKNIKMASFLPVPEKPNLIYLFMTYTSCEDNKFSEPVVMTLNKENTLNQFKNLGLLDSNVTDFEKCVEYIRKQAILTGFKISNPFVNSTLVDTDAEKINSFHLQCHRGTKEGTLYFLPDHIIFGFKKPILLFDASDIESITYSSITRLTFNASLVTKDGEKYEFSMIDQTEYAKIDDYVKRKQMKDKSMSEELKAKSKSKGQATDGTADQPSILQEATRQMQDEKKAGVFSDDDEENDQNFEAESDLSDGSGQESSDGAEDGEEAEEDDEEDDEEEDKKGQSALNRDNSFASINGQPEQELQYKEFKEPLELEDIPIEIDNDDDEDDEDGSGVEYD
SIO_010081: YNL206C
subclass of: SO_0000673
so part of: YNL206C
location: complement(256788..258155)
location: region:256788-258155:-1
so has part: feature:256788-258155:-1:exon

NP_014193.1
type: Protein
SIO_000068: ncbiprotein

S000005150
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256788-258155:-1:exon

YNL204C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPX18
gene: SPS18
locus tag: YNL204C
gene synonym: SPX18
so part of: sequence
location: complement(<258375..>259277)
location: region:258375-259277:-1
so has part: feature:258375-259277:-1:exon
subclass of: SO_0000010

855517
type: Gene
SIO_000068: ncbigene

position:258375:-1
position: 258375
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259277:-1
position: 259277
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:258375-259277:-1:exon

YNL204C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPX18
gene: SPS18
locus tag: YNL204C
gene synonym: SPX18
product: Sps18p
transcript id: NM_001183042.1
SIO_010081: YNL204C
subclass of: SO_0000673
so part of: YNL204C
location: complement(<258375..>259277)
location: region:258375-259277:-1
so has part: feature:258375-259277:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:258375-259277:-1:exon

YNL204C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPX18
gene: SPS18
locus tag: YNL204C
gene synonym: SPX18
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]
note: hypothetical protein, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication
codon start: 1
product: Sps18p
translation: MRLFENSKDMENRKRLLRAKKAAGNNNCFECKSVNPQFVSCSFGIFICVNCANLLRGMGTNIFCVKSITMDNFEEKDVRRVEKSGNNRFGSFLSKNGILQNGIPLREKYDNLFAKSYKRRLANEVRSNDINRNMYLGFNNFQQYTNGATSQIRDRTLREISNNSNASEGAEFVLPEKVLGSDNFQDCERFPACLSSERNLDENNVTSATSTLTIEKFQNDPIGTISRSWQLLSDALYKSYEDFKGSVVQPTIENIQQRNLPNDIKRSFVHFNEKLHETPHLPSPVFSCFTGGDILPPEFN
SIO_010081: YNL204C
subclass of: SO_0000673
so part of: YNL204C
location: complement(258375..259277)
location: region:258375-259277:-1
so has part: feature:258375-259277:-1:exon

NP_014195.1
type: Protein
SIO_000068: ncbiprotein

S000005148
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:258375-259277:-1:exon

YNL202W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPX19
gene: SPS19
locus tag: YNL202W
gene synonym: SPX19
so part of: sequence
location: <259578..>260456
location: region:259578-260456:1
so has part: feature:259578-260456:1:exon
subclass of: SO_0000010

855518
type: Gene
SIO_000068: ncbigene

position:259578:1
position: 259578
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:260456:1
position: 260456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259578-260456:1:exon

YNL202W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPX19
gene: SPS19
locus tag: YNL202W
gene synonym: SPX19
product: 2,4-dienoyl-CoA reductase (NADPH)
transcript id: NM_001183040.1
SIO_010081: YNL202W
subclass of: SO_0000673
so part of: YNL202W
location: <259578..>260456
location: region:259578-260456:1
so has part: feature:259578-260456:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:259578-260456:1:exon

YNL202W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPX19
gene: SPS19
locus tag: YNL202W
gene synonym: SPX19
EC number: 1.3.1.124
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:9268358]
experiment: EXISTENCE:direct assay:GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity [PMID:9268358]
experiment: EXISTENCE:direct assay:GO:0009062 fatty acid catabolic process [PMID:9268358]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]
note: Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
codon start: 1
product: 2,4-dienoyl-CoA reductase (NADPH)
translation: MNTANTLDGKFVTEGSWRPDLFKGKVAFVTGGAGTICRVQTEALVLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAIANVDVRNFEQVENAVKKTVEKFGKIDFVIAGAAGNFVCDFANLSPNAFKSVVDIDLLGSFNTAKACLKELKKSKGSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVELGPLGIRSNCIAPGAIDNTEGLKRLAGKKYKEKALAKIPLQRLGSTRDIAESTVYIFSPAASYVTGTVLVVDGGMWHLGTYFGHELYPEALIKSMTSKL
SIO_010081: YNL202W
subclass of: SO_0000673
so part of: YNL202W
location: 259578..260456
location: region:259578-260456:1
so has part: feature:259578-260456:1:exon

NP_014197.2
type: Protein
SIO_000068: ncbiprotein

S000005146
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259578-260456:1:exon

YNL201C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSY2
locus tag: YNL201C
so part of: sequence
location: complement(<260627..>263203)
location: region:260627-263203:-1
so has part: feature:260627-263203:-1:exon
subclass of: SO_0000010

855520
type: Gene
SIO_000068: ncbigene

position:260627:-1
position: 260627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263203:-1
position: 263203
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:260627-263203:-1:exon

YNL201C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSY2
locus tag: YNL201C
product: Psy2p
transcript id: NM_001183039.1
SIO_010081: YNL201C
subclass of: SO_0000673
so part of: YNL201C
location: complement(<260627..>263203)
location: region:260627-263203:-1
so has part: feature:260627-263203:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:260627-263203:-1:exon

YNL201C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSY2
locus tag: YNL201C
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:20951350]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:17517611]
experiment: EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:16299494|PMID:17517611]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:15598824]
experiment: EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]
experiment: EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:20951350]
experiment: EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:24277933]
experiment: EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:16299494|PMID:17517611]
experiment: EXISTENCE:mutant phenotype:GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining [PMID:24498054]
note: Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
codon start: 1
product: Psy2p
translation: MSLPGTPTTSPTPMDEDTEQAVSVNTEPKRVKVYILENNEWKDTGTGFCIGEVDEGKFAYLVVSDEDSPTETLLKSKLEGNIEYQRQEETLIVWKDLGGKDIALSFEESMGCDTLCEFIVHVQRNIESNISLVTVKSSDNGLGSVHDIITGPVTLPSNDQQQNSQTLLEALKILNENTSFDFLKNETIEFILQSNYIDTLISHFHKAEEEKIPKDLFLLSNIIKTLILYNKRDILESMVEDDRIMGIVGILEYDTEYPTSKANHRKYLGSKGPNFKEVIPLENEDLKIIMKKCFRLQFLKDVVLVRFLDDHNFNLISEIVMDLETCIIDFLQVGTFLDRLIELYDTKTLPESSSEKEKFVQKRKDGIRLLQQCVQMSINLDAVDRSKFYKTLVRKGLFKVLDYAFHMETDSNVRILATDTIITIIEHDILLIHNVQNEDSFKRQHKSAPDDKSSHRKYPQDYSSSTDSKLLLILSTILLSDRSPGLREQVVQALNTLLHPEGCVGNGEGSYDLMGRSNYEAKNTSEDFPSFSYGLNSDSINLNNYHYSSDEMNNLEPESESEFQVMEYFANFYNKIAPILFGPLIKKDITTEMAEIDGQIEKVTKDDLLLIHLVKLVSFVCTEHDRVLSRRFILENGILDSVSKLIGGNHMMQLRLTAVRCIKNLMCLDDKYYHRYMISKNLYAPVFKLFQENIDKNNLANSCIQDFFRIIITECRAYQSDGHNRKEKTNGSYDGNGNDVKTNVNNNRTNFTILNKYLVQTYGDVLRKATDIPFIQDMLETGEENQPDHSSFENSIEGGNDISVNMSTDGFASNHLEDIDIKNVKRLHSEIEHFENDPHYSGDQLAFKKSVDQMNAST
SIO_010081: YNL201C
subclass of: SO_0000673
so part of: YNL201C
location: complement(260627..263203)
location: region:260627-263203:-1
so has part: feature:260627-263203:-1:exon

NP_014198.1
type: Protein
SIO_000068: ncbiprotein

S000005145
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:260627-263203:-1:exon

YNL200C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NNR1
locus tag: YNL200C
so part of: sequence
location: complement(<263713..>264453)
location: region:263713-264453:-1
so has part: feature:263713-264453:-1:exon
subclass of: SO_0000010

855521
type: Gene
SIO_000068: ncbigene

position:263713:-1
position: 263713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:264453:-1
position: 264453
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263713-264453:-1:exon

YNL200C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NNR1
locus tag: YNL200C
product: NADHX epimerase
transcript id: NM_001183038.1
SIO_010081: YNL200C
subclass of: SO_0000673
so part of: YNL200C
location: complement(<263713..>264453)
location: region:263713-264453:-1
so has part: feature:263713-264453:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263713-264453:-1:exon

YNL200C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NNR1
locus tag: YNL200C
EC number: 5.1.99.6
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21994945]
experiment: EXISTENCE:direct assay:GO:0052856 NADHX epimerase activity [PMID:21994945]
note: NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: NADHX epimerase
translation: MSTLKVVSSKLAAEIDKELMGPQIGFTLQQLMELAGFSVAQAVCRQFPLRGKTETEKGKHVFVIAGPGNNGGDGLVCARHLKLFGYNPVVFYPKRSERTEFYKQLVHQLNFFKVPVLSQDEGNWLEYLKPEKTLCIVDAIFGFSFKPPMREPFKGIVEELCKVQNIIPIVSVDVPTGWDVDKGPISQPSINPAVLVSLTVPKPCSSHIRENQTTHYVGGRFIPRDFANKFGFEPFGYESTDQILKL
SIO_010081: YNL200C
subclass of: SO_0000673
so part of: YNL200C
location: complement(263713..264453)
location: region:263713-264453:-1
so has part: feature:263713-264453:-1:exon

NP_014199.1
type: Protein
SIO_000068: ncbiprotein

S000005144
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263713-264453:-1:exon

YNL199C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GCR2
locus tag: YNL199C
so part of: sequence
location: complement(<264926..>266530)
location: region:264926-266530:-1
so has part: feature:264926-266530:-1:exon
subclass of: SO_0000010

855522
type: Gene
SIO_000068: ncbigene

position:264926:-1
position: 264926
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266530:-1
position: 266530
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264926-266530:-1:exon

YNL199C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GCR2
locus tag: YNL199C
product: Gcr2p
transcript id: NM_001183037.1
SIO_010081: YNL199C
subclass of: SO_0000673
so part of: YNL199C
location: complement(<264926..>266530)
location: region:264926-266530:-1
so has part: feature:264926-266530:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264926-266530:-1:exon

YNL199C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GCR2
locus tag: YNL199C
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15817685]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15817685]
experiment: EXISTENCE:direct assay:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11333224]
experiment: EXISTENCE:genetic interaction:GO:0003712 transcription coregulator activity [PMID:11333224]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10455229|PMID:15789351|PMID:27190003|PMID:9335590|PM ID:11333224|PMID:2247062]
experiment: EXISTENCE:mutant phenotype:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:11333224]
note: Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
codon start: 1
product: Gcr2p
translation: MHHQTKLDVFIIRAYNLLSNESVISGASLQSVTNSPQTTTNTPSGMVNGAVGTGIANPTGLMGSDSTPNIDEIITSTGSNALTKTNSDSANGTPNGNSSSTSAISNASNPATTGNNASSSATSNGIYTQAQYSQLFAKISKLYNATLSSGSIDDRSTSPKSAIELYQRFQQMIKELELSFDASPYAKYFRRLDGRLWQIKTDSELENDELWRLVSMSIFTVFDPQTGQILTQGRRKGNSLNTSTKGSPSDLQGINNGNNNGNNGNIGNGSNIKNYGNKNMPNNRTKKRGTRVAKNAKNGKNNKNSNKERNGITDTSAFSNTTISNPGTNMLFDPSLSQQLQKRLQTLSQDVNSRSLTGYYTQPTSPGSGGFEFGLSHADLNPNASSNTMGYNTMSNNGSHSWKRRSLGSLDVNTLDDEAVEELLQLTNTSKRQRPMTTAAEGALINDGPDTNLNANNTQMKVDLNPSNSMGPIDTEAVIRPLKEAYDAIISEKGQRIVQLERELELQRQETQWLRKMLIEDMGCVRSMLRDLQR
SIO_010081: YNL199C
subclass of: SO_0000673
so part of: YNL199C
location: complement(264926..266530)
location: region:264926-266530:-1
so has part: feature:264926-266530:-1:exon

NP_014200.1
type: Protein
SIO_000068: ncbiprotein

S000005143
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264926-266530:-1:exon

YNL197C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WHI3
locus tag: YNL197C
so part of: sequence
location: complement(<267608..>269593)
location: region:267608-269593:-1
so has part: feature:267608-269593:-1:exon
subclass of: SO_0000010

855524
type: Gene
SIO_000068: ncbigene

position:267608:-1
position: 267608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:269593:-1
position: 269593
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267608-269593:-1:exon

YNL197C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WHI3
locus tag: YNL197C
product: mRNA-binding protein WHI3
transcript id: NM_001183035.1
SIO_010081: YNL197C
subclass of: SO_0000673
so part of: YNL197C
location: complement(<267608..>269593)
location: region:267608-269593:-1
so has part: feature:267608-269593:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267608-269593:-1:exon

YNL197C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WHI3
locus tag: YNL197C
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:24386402]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11691832|PMID:24386402]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11691832]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:35085498]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:24386330|PMID:24386402|PMID:26777405]
experiment: EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14685274]
experiment: EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:11691832]
experiment: EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14685274|PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0061013 regulation of mRNA catabolic process [PMID:24386330]
experiment: EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:24386402]
note: RNA binding protein that modulates mRNA stability; regulates cell cycle, sister chromatid cohesion, and stress response genes; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules to regulate target mRNAs; regulates cell fate and critical cell size for Start passage; regulates ploidy; self-templating mnemon that forms inactive super-assemblies, preventing G1 arrest in mother cells after unsuccessful mating and causing sterility in old cells
codon start: 1
product: mRNA-binding protein WHI3
translation: MQSSVYFDQTGSFASSSDNVVSSTTNTHNISPSHRSSLNLNTTSHPHEASGRGSASGELYLNDTNSPLAISSMLNTLALGSMPQDIASSNISNHDNNIKGSYSLKLSNVAKDITLRECYAIFALAEGVKSIELQKKNSSSSITSASLEDENDIFIIARFELLNLAINYAVILNSKNELFGPSFPNKTTVEIIDDTTKNLVSFPSSAIFNDTSRLNKSNSGMKRPSLLSQRSRFSFSDPFSNDSPLSQQQSQQQQQQPQQPQQHSTQKHSPQQCNQQQVNSSIPLSSQGQVIGLHSNHSHQDLSVESTIQTSDIGKSFLLRDNTEINEKIWGTSGIPSSINGYMSTPQPSTPTLEWGNTSASQHGSSFFLPSAASTAIAPTNSNTSANANASSNNGASNNGANQALSASSQQPMMQIGNTINTSLTSSNSLPPYGLMSSQSQHISNMVNTSDMNITPQKQNRFMQQPQPEHMYPVNQSNTPQKVPPARLSSSRNSHKNNSTTSLSSNITGSASISQADLSLLARIPPPANPADQNPPCNTLYVGNLPSDATEQELRQLFSGQEGFRRLSFRNKNTTSNGHSHGPMCFVEFDDVSFATRALAELYGRQLPRSTVSSKGGIRLSFSKNPLGVRGPNSRRGGSGNPNPNVNMLSSYNSNVGHIKN
SIO_010081: YNL197C
subclass of: SO_0000673
so part of: YNL197C
location: complement(267608..269593)
location: region:267608-269593:-1
so has part: feature:267608-269593:-1:exon

NP_014202.1
type: Protein
SIO_000068: ncbiprotein

S000005141
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267608-269593:-1:exon

YNL196C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLZ1
locus tag: YNL196C
so part of: sequence
location: complement(<270275..>271171)
location: region:270275-271171:-1
so has part: feature:270275-271171:-1:exon
subclass of: SO_0000010

855525
type: Gene
SIO_000068: ncbigene

position:270275:-1
position: 270275
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271171:-1
position: 271171
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270275-271171:-1:exon

YNL196C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLZ1
locus tag: YNL196C
product: Slz1p
transcript id: NM_001183034.1
SIO_010081: YNL196C
subclass of: SO_0000673
so part of: YNL196C
location: complement(<270275..>271171)
location: region:270275-271171:-1
so has part: feature:270275-271171:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270275-271171:-1:exon

YNL196C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLZ1
locus tag: YNL196C
experiment: EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]
experiment: EXISTENCE:genetic interaction:GO:0080009 mRNA methylation [PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:0080009 mRNA methylation [PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22685417]
experiment: EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]
note: Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation
codon start: 1
product: Slz1p
translation: MMNKVDQIIGYKKYEVKLPKDRQVKKNKSKGGNVDQIDTKREKDKMRAFGEERKKFLDKMAKNKKKNTSRKDREKPKEVEKENYKREDKRLKEQKKLSLAKEFRFKEPNSEAINQNTAAENGKPKPQTGLDFDIDHQTVSKIMIDQAIQTSSPLNVQLTELFNDNVLDVSKDSQFVLQDMEFTSWERRWSNCSTTSNATTVSSVPDPKYNINYNDITSFNSVALITEDLNISASSNGLHERGKKLLQQEMEYSNKVKNVTIGLERLCMDEKPVPDAGITMQQASRWSEFPTCCDQAAI
SIO_010081: YNL196C
subclass of: SO_0000673
so part of: YNL196C
location: complement(270275..271171)
location: region:270275-271171:-1
so has part: feature:270275-271171:-1:exon

NP_014203.1
type: Protein
SIO_000068: ncbiprotein

S000005140
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270275-271171:-1:exon

YNL195C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL195C
so part of: sequence
location: complement(<271523..>272308)
location: region:271523-272308:-1
so has part: feature:271523-272308:-1:exon
subclass of: SO_0000010

855526
type: Gene
SIO_000068: ncbigene

position:271523:-1
position: 271523
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:272308:-1
position: 272308
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271523-272308:-1:exon

YNL195C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL195C
product: uncharacterized protein
transcript id: NM_001183033.1
SIO_010081: YNL195C
subclass of: SO_0000673
so part of: YNL195C
location: complement(<271523..>272308)
location: region:271523-272308:-1
so has part: feature:271523-272308:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271523-272308:-1:exon

YNL195C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL195C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MLGLGQSAQAYASDDALNMNQAKDKTYSVPGCGRASDLKYPHRDGHSSSHEQRSGILPTECPGPTLNTGAGSIGIPGCGKVTNRVVSDYNKNARSTLANFDSSKMTEARMNSKNVPIGCQDTSDPHFNGPIDQHVPGAGSPQSQPHHIDAWNSVSSRRADNNNQDMMDPQTASSDRYNEKMMREENSGVSASSYTTKVQGYPASIPSFNQETEEKETYAYGVGDRHNVPRNQIMDETNPSANVLNATDHSISHPENKVLHK
SIO_010081: YNL195C
subclass of: SO_0000673
so part of: YNL195C
location: complement(271523..272308)
location: region:271523-272308:-1
so has part: feature:271523-272308:-1:exon

NP_014204.2
type: Protein
SIO_000068: ncbiprotein

S000005139
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271523-272308:-1:exon

YNL194C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL194C
so part of: sequence
location: complement(<272710..>273615)
location: region:272710-273615:-1
so has part: feature:272710-273615:-1:exon
subclass of: SO_0000010

855527
type: Gene
SIO_000068: ncbigene

position:272710:-1
position: 272710
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273615:-1
position: 273615
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272710-273615:-1:exon

YNL194C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL194C
product: uncharacterized protein
transcript id: NM_001183032.1
SIO_010081: YNL194C
subclass of: SO_0000673
so part of: YNL194C
location: complement(<272710..>273615)
location: region:272710-273615:-1
so has part: feature:272710-273615:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272710-273615:-1:exon

YNL194C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL194C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]
note: Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSYKKFVYFINLFFLLGATLLTFFLILAGGRTTGVLKNFYWFQASTSGFNSAPSVTRWYNYNWCGWESRGIAVNCSSKMAAQPFSPRDNFGSSPLMPSTFLNNRNAYYYLSRVGWAMLLIGLFFLLITLVSVIASLIRYNRRTAALATAMSWITLFFITLSACLYTGCYAKAVKAFHHENRDARLGPKNFGLIWTTVFLLIVNAICCTIMVATHKRNEYIYDRSFASTKTVDSQTPTPVPTNGGIPSSVPVTEVQQSQSHQNHRFFKKLRTKKRTVTSAGDEPDRVQEERVYTEQNVPVVS
SIO_010081: YNL194C
subclass of: SO_0000673
so part of: YNL194C
location: complement(272710..273615)
location: region:272710-273615:-1
so has part: feature:272710-273615:-1:exon

NP_014205.1
type: Protein
SIO_000068: ncbiprotein

S000005138
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272710-273615:-1:exon

YNL193W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL193W
so part of: sequence
location: <274368..>276044
location: region:274368-276044:1
so has part: feature:274368-276044:1:exon
subclass of: SO_0000010

855528
type: Gene
SIO_000068: ncbigene

position:274368:1
position: 274368
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276044:1
position: 276044
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274368-276044:1:exon

YNL193W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL193W
product: uncharacterized protein
transcript id: NM_001183031.2
SIO_010081: YNL193W
subclass of: SO_0000673
so part of: YNL193W
location: <274368..>276044
location: region:274368-276044:1
so has part: feature:274368-276044:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274368-276044:1:exon

YNL193W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL193W
note: hypothetical protein; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
codon start: 1
product: uncharacterized protein
translation: MGPPKNFKHFSKSNKHKKEQKALITQEDFYLAAIDCEEQADRWLLSDIKKCLRFYLKALEHYENGLTALDSTQEGKYNIYYNETRLFLQIYTDYLANNGYINILQYVKMDDMPDLSNLVLSLPQIIQRFEIVYETFPEQRTWDLQFNLLTCYLTLIESLDDTVSPTVAMEGADILTLTNKYIEIFQHLVNYLLQELQNWSENAEQDSDDTDTELQRDTLDEDAMQVTRDGSGIRTNGPVQPPAEVMDVSEQVTPSSLTEVLANSLKFNHALMELVIESKISIEKNVETKILNPIQINFLEDTTNKFYLQLRDIIDSISAAIPLDLKEIGLAKTLIEGLNIISSGTFESLQDFVLQTVSFTDLLDEKDVQGKIDLSLIRVDIVEFAILCLNDYSSDASWKLSGLLTKVLTEARTLLTDYRNQILFLKNQTLNEQLSHVVFQLCDVLVNSSDNELRRYAIKESTEKSQKTPGGAHTLNILMKNANVFLNNAVAISSKQCGLQETIIDKLKRNYIHNQAKERLLFLQRLEQKSNEDDGTSASPTAMTFDMPPEHPFYSHYR
SIO_010081: YNL193W
subclass of: SO_0000673
so part of: YNL193W
location: 274368..276044
location: region:274368-276044:1
so has part: feature:274368-276044:1:exon

NP_014206.2
type: Protein
SIO_000068: ncbiprotein

S000005137
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274368-276044:1:exon

YNL192W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: USA4
gene: CHS1
locus tag: YNL192W
gene synonym: USA4
so part of: sequence
location: <276502..>279897
location: region:276502-279897:1
so has part: feature:276502-279897:1:exon
subclass of: SO_0000010

855529
type: Gene
SIO_000068: ncbigene

position:276502:1
position: 276502
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:279897:1
position: 279897
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276502-279897:1:exon

YNL192W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: USA4
gene: CHS1
locus tag: YNL192W
gene synonym: USA4
product: chitin synthase CHS1
transcript id: NM_001183030.2
SIO_010081: YNL192W
subclass of: SO_0000673
so part of: YNL192W
location: <276502..>279897
location: region:276502-279897:1
so has part: feature:276502-279897:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:276502-279897:1:exon

YNL192W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: USA4
gene: CHS1
locus tag: YNL192W
gene synonym: USA4
EC number: 2.4.1.16
experiment: EXISTENCE:direct assay:GO:0004100 chitin synthase activity [PMID:7952171]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8970154]
experiment: EXISTENCE:direct assay:GO:0045009 chitosome [PMID:8970154]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:2523889]
note: Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor
codon start: 1
product: chitin synthase CHS1
translation: MSDQNNRSRNEYHSNRKNEPSYELQNAHSGLFHSSNEELTNRNQRYTNQNASMGSFTPVQSLQFPEQSQQTNMLYNGDDGNNNTINDNERDIYGGFVNHHRQRPPPATAEYNDVFNTNSQQLPSEHQYNNVPSYPLPSINVIQTTPELIHNGSQTMATPIERPFFNENDYYYNNRNSRTSPSIASSSDGYADQEARPILEQPNNNMNSGNIPQYHDQPFGYNNGYHGLQAKDYYDDPEGGYIDQRGDDYQINSYLGRNGEMVDPYDYENSLRHMTPMERREYLHDDSRPVNDGKEELDSVKSGYSHRDLGEYDKDDFSRDDEYDDLNTIDKLQFQANGVPASSSVSSIGSKESDIIVSNDNLTANRALKRSGTEIRKFKLWNGNFVFDSPISKTLLDQYATTTENANTLPNEFKFMRYQAVTCEPNQLAEKNFTVRQLKYLTPRETELMLVVTMYNEDHILLGRTLKGIMDNVKYMVKKKNSSTWGPDAWKKIVVCIISDGRSKINERSLALLSSLGCYQDGFAKDEINEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQLLFCLKEQNQKKINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNVGGACGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGAFSAYRFEAVRGQPLQKYFYGEIMENEGFHFFSSNMYLAEDRILCFEVVTKKNCNWILKYCRSSYASTDVPERVPEFILQRRRWLNGSFFASVYSFCHFYRVWSSGHNIGRKLLLTVEFFYLFFNTLISWFSLSSFFLVFRILTVSIALAYHSAFNVLSVIFLWLYGICTLSTFILSLGNKPKSTEKFYVLTCVIFAVMMIYMIFCSIFMSVKSFQNILKNDTISFEGLITTEAFRDIVISLGSTYCLYLISSIIYLQPWHMLTSFIQYILLSPSYINVLNIYAFCNVHDLSWGTKGAMANPLGKINTTEDGTFKMEVLVSSSEIQANYDKYLKVLNDFDPKSESRPTEPSYDEKKTGYYANVRSLVIIFWVITNFIIVAVVLETGGIADYIAMKSISTDDTLETAKKAEIPLMTSKASIYFNVILWLVALSALIRFIGCSIYMIVRFFKKVTFR
SIO_010081: YNL192W
subclass of: SO_0000673
so part of: YNL192W
location: 276502..279897
location: region:276502-279897:1
so has part: feature:276502-279897:1:exon

NP_014207.2
type: Protein
SIO_000068: ncbiprotein

S000005136
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:276502-279897:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1414; ARS activated in mid-S phase
so part of: sequence
location: 279982..280071
location: region:279982-280071:1
so has part: feature:279982-280071:1:region

S000077376
type: SGD
SIO_000068: sgd

position:279982:1
position: 279982
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:280071:1
position: 280071
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:279982-280071:1:region

YNL191W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUG3
locus tag: YNL191W
so part of: sequence
location: <280432..>281505
location: region:280432-281505:1
so has part: feature:280432-281505:1:exon
subclass of: SO_0000010

855530
type: Gene
SIO_000068: ncbigene

position:280432:1
position: 280432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281505:1
position: 281505
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280432-281505:1:exon

YNL191W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUG3
locus tag: YNL191W
product: glutamine amidotransferase subunit DUG3
transcript id: NM_001183029.1
SIO_010081: YNL191W
subclass of: SO_0000673
so part of: YNL191W
location: <280432..>281505
location: region:280432-281505:1
so has part: feature:280432-281505:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280432-281505:1:exon

YNL191W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUG3
locus tag: YNL191W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17179087|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:22277648]
experiment: EXISTENCE:direct assay:GO:0036374 glutathione hydrolase activity [PMID:22277648]
experiment: EXISTENCE:direct assay:GO:0061672 glutathione hydrolase complex [PMID:22277648]
experiment: EXISTENCE:genetic interaction:GO:0008233 peptidase activity [PMID:17179087]
experiment: EXISTENCE:genetic interaction:GO:0008242 omega peptidase activity [PMID:17179087]
experiment: EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:17179087|PMID:22277648]
note: Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
codon start: 1
product: glutamine amidotransferase subunit DUG3
translation: MCRFLIFKGKQPIRLSHLLTRPAHSIINQSFDSRLRLDRRRPMNGDGFGVAYYPLDTELSEDGPCLFKAITPAWNNQNLSTLAEKTKSDLVFAHVRASTYGVLSETNCHPFTYHSLCFMHNGGISNFKGIKRKLLNHIKDEYLNFIQGSTDSECAFALFLDTLDKLGYDPKKQDGDFGNVALRKAMLRTIDYIRDWTKEANKDEAHVEPSLLNFAVTDGSTVVVSRYITSKTDEAASLHFSCGSSFVETSPGEYRVERLDRNQDVIMVASEPLTFERGDWTAVPTNSILTIKKQTILLHPIIDEYYQEDPLYLRSSTLAESKGLMGSIPLAKAVEKNVPPLEREGRTRPPTAVAHIA
SIO_010081: YNL191W
subclass of: SO_0000673
so part of: YNL191W
location: 280432..281505
location: region:280432-281505:1
so has part: feature:280432-281505:1:exon

NP_014208.1
type: Protein
SIO_000068: ncbiprotein

S000005135
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280432-281505:1:exon

YNL190W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL190W
so part of: sequence
location: <282395..>283009
location: region:282395-283009:1
so has part: feature:282395-283009:1:exon
subclass of: SO_0000010

855531
type: Gene
SIO_000068: ncbigene

position:282395:1
position: 282395
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283009:1
position: 283009
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282395-283009:1:exon

YNL190W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL190W
product: uncharacterized protein
transcript id: NM_001183028.1
SIO_010081: YNL190W
subclass of: SO_0000673
so part of: YNL190W
location: <282395..>283009
location: region:282395-283009:1
so has part: feature:282395-283009:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282395-283009:1:exon

YNL190W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL190W
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:22442684]
note: Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site
codon start: 1
product: uncharacterized protein
translation: MKFSSVTAITLATVATVATAKKGEHDFTTTLTLSSDGSLTTTTSTHTTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTSKSKTPNHTGTHKYGKFNKTKHDTTTYGPGEKARKNNAAPGPSNFNSIKLFGVTAGSAAVAGALLLL
SIO_010081: YNL190W
subclass of: SO_0000673
so part of: YNL190W
location: 282395..283009
location: region:282395-283009:1
so has part: feature:282395-283009:1:exon

NP_014209.1
type: Protein
SIO_000068: ncbiprotein

S000005134
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282395-283009:1:exon

YNL189W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KAP60
alternative label: SCM1
gene: SRP1
locus tag: YNL189W
gene synonym: KAP60; SCM1
so part of: sequence
location: <284260..>285888
location: region:284260-285888:1
so has part: feature:284260-285888:1:exon
subclass of: SO_0000010

855532
type: Gene
SIO_000068: ncbigene

position:284260:1
position: 284260
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:285888:1
position: 285888
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284260-285888:1:exon

YNL189W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KAP60
alternative label: SCM1
gene: SRP1
locus tag: YNL189W
gene synonym: KAP60; SCM1
product: karyopherin alpha
transcript id: NM_001183027.1
SIO_010081: YNL189W
subclass of: SO_0000673
so part of: YNL189W
location: <284260..>285888
location: region:284260-285888:1
so has part: feature:284260-285888:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:284260-285888:1:exon

YNL189W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KAP60
alternative label: SCM1
gene: SRP1
locus tag: YNL189W
gene synonym: KAP60; SCM1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10725229|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10725229]
experiment: EXISTENCE:direct assay:GO:0042564 NLS-dependent protein nuclear import complex [PMID:19141610]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:7622450]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:19141610]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:16929305]
experiment: EXISTENCE:mutant phenotype:GO:0031144 proteasome localization [PMID:25274630]
note: Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation
codon start: 1
product: karyopherin alpha
translation: MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQFYSQLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFGFGSNVNQQFNFN
SIO_010081: YNL189W
subclass of: SO_0000673
so part of: YNL189W
location: 284260..285888
location: region:284260-285888:1
so has part: feature:284260-285888:1:exon

NP_014210.1
type: Protein
SIO_000068: ncbiprotein

S000005133
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:284260-285888:1:exon

YNL188W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KAR1
locus tag: YNL188W
so part of: sequence
location: <286308..>287609
location: region:286308-287609:1
so has part: feature:286308-287609:1:exon
subclass of: SO_0000010

855533
type: Gene
SIO_000068: ncbigene

position:286308:1
position: 286308
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:287609:1
position: 287609
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286308-287609:1:exon

YNL188W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KAR1
locus tag: YNL188W
product: Kar1p
transcript id: NM_001183026.1
SIO_010081: YNL188W
subclass of: SO_0000673
so part of: YNL188W
location: <286308..>287609
location: region:286308-287609:1
so has part: feature:286308-287609:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:286308-287609:1:exon

YNL188W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KAR1
locus tag: YNL188W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:10428957]
experiment: EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:1607389]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:3030557]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10428957|PMID:8188750]
note: Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene
codon start: 1
product: Kar1p
translation: MNVTSPKDGNHSFSKKNRFNTNKPRFHKLNEQAQSINLPEDRDSIVSSNTTSIMTDDAFDYNEGIASRTKNINSDSDRSNDTIKQNNYNKRETGYNPFYNGSGINQRYTQFRKREFEPTLAENKAEEYISDEDNVKIDEDNIENELQFTPKIKEASILRSSLLGQRNVLNTRNPKSKESHIKVKPIINNKSSSQRKSSAALRKQLGKPLPLPYLNSPNSDSTPTLQRKEEVFTDEVLQKKRELIESKWHRLLFHDKKMVEKKLESLREYERKRMPPRGTDVSSSEQDNSFKISTPTKSYVSLEQKPLPNLSAMNNFNDVTDNKEKEETNNNILKFQAQRDPLQILQSEIEMHTKKLDTIIELLKDDTDSKEKRKVVTNDNAAPEQMVNKGWRKNVMMIYKKSGNIMKKYREYFLWTICILILLYCNIYVYYRF
SIO_010081: YNL188W
subclass of: SO_0000673
so part of: YNL188W
location: 286308..287609
location: region:286308-287609:1
so has part: feature:286308-287609:1:exon

NP_014211.1
type: Protein
SIO_000068: ncbiprotein

S000005132
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:286308-287609:1:exon

YNL187W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SWT21
locus tag: YNL187W
so part of: sequence
location: <287994..>289067
location: region:287994-289067:1
so has part: feature:287994-289067:1:exon
subclass of: SO_0000010

855534
type: Gene
SIO_000068: ncbigene

position:287994:1
position: 287994
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:289067:1
position: 289067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287994-289067:1:exon

YNL187W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SWT21
locus tag: YNL187W
product: Swt21p
transcript id: NM_001183025.1
SIO_010081: YNL187W
subclass of: SO_0000673
so part of: YNL187W
location: <287994..>289067
location: region:287994-289067:1
so has part: feature:287994-289067:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:287994-289067:1:exon

YNL187W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SWT21
locus tag: YNL187W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19451230]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19451230]
note: Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
codon start: 1
product: Swt21p
translation: MEKKVICQDIFWSCDGTSFVSVHNDFGIRQYLVPEESNTDKLNRNLLLPFTRFFRNQSIVSCAIDPFYTLYNENSDRLAGDRIVVGGKNFPLQLYSLMDGQCILSYDTMNKINGEYETVYSVKIDVESRVYTGSCRNKVAIYDKSRRDAVWMNQSTKKASKGRQSIISCFEEQPMGGQALSRGSLLCGSYANEMFQVDCRHQRLERLNYTRTVAGGIVQILTSDNGRYVYVVRRNSDAISIYDRRNLQHELNVLRLPFRIHHNSAKLKAYIDTAYGLSMGTPQGTILNWGRDLVEFGGVPSHNSVEDPLITSIPPESEWRTNLDSTIPATVVKNCPGDPELFALSHGGTISLCRFGG
SIO_010081: YNL187W
subclass of: SO_0000673
so part of: YNL187W
location: 287994..289067
location: region:287994-289067:1
so has part: feature:287994-289067:1:exon

NP_014212.1
type: Protein
SIO_000068: ncbiprotein

S000005131
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:287994-289067:1:exon

YNL186W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DOT4
gene: UBP10
locus tag: YNL186W
gene synonym: DOT4
so part of: sequence
location: <289498..>291876
location: region:289498-291876:1
so has part: feature:289498-291876:1:exon
subclass of: SO_0000010

855535
type: Gene
SIO_000068: ncbigene

position:289498:1
position: 289498
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:291876:1
position: 291876
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:289498-291876:1:exon

YNL186W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DOT4
gene: UBP10
locus tag: YNL186W
gene synonym: DOT4
product: ubiquitin-specific protease UBP10
transcript id: NM_001183024.2
SIO_010081: YNL186W
subclass of: SO_0000673
so part of: YNL186W
location: <289498..>291876
location: region:289498-291876:1
so has part: feature:289498-291876:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:289498-291876:1:exon

YNL186W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DOT4
gene: UBP10
locus tag: YNL186W
gene synonym: DOT4
EC number: 3.4.19.12
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:10490600]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10490600|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22902402]
experiment: EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:15721261]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:31665643]
experiment: EXISTENCE:mutant phenotype:GO:0016578 histone deubiquitination [PMID:22829782]
experiment: EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:15721261|PMID:22829782|PMID:31665643]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15721261|PMID:26587833]
experiment: EXISTENCE:mutant phenotype:GO:2001020 regulation of response to DNA damage stimulus [PMID:31665643]
note: Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36
codon start: 1
product: ubiquitin-specific protease UBP10
translation: MTTQESIKPLVDRILSNPLQFNAAMISNKSNNNDTSAAPENSSYIVIGKQHNNNSNSTAIAATAESKQIKENNLIDRPNGKKTNTVPKSMAEALLLYTSKNDKDAADATGAKKSAELSTELSTEPPSSSSEDDKVGKEEEEEGEIFHEARDYVEPRKASLKERDNADKGDGEDIGEDIGEDIGEDIGEDIGEDIGENLGSPLATIDDSSNENEKEKRKELSTSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMENSTVEVNRYEPVNNTKENGNRNPKGEEEEEEEEELKHKSRSITPPVTISNLSNFYQFNENINDRGSLNSTRIVKNWGDKFTNLKPRGLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQEDSHEYFMSLMSRLQEDSVPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLSSANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNGTSSSKMKQAVSYPMFLDLTEYCESKELPVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPNNRPLKINSKKNNRKKWKKNKKRKFTK
SIO_010081: YNL186W
subclass of: SO_0000673
so part of: YNL186W
location: 289498..291876
location: region:289498-291876:1
so has part: feature:289498-291876:1:exon

NP_014213.2
type: Protein
SIO_000068: ncbiprotein

S000005130
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:289498-291876:1:exon

YNL185C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL11m
gene: MRPL19
locus tag: YNL185C
gene synonym: uL11m
so part of: sequence
location: complement(<292193..>292669)
location: region:292193-292669:-1
so has part: feature:292193-292669:-1:exon
subclass of: SO_0000010

855536
type: Gene
SIO_000068: ncbigene

position:292193:-1
position: 292193
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292669:-1
position: 292669
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292193-292669:-1:exon

YNL185C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL11m
gene: MRPL19
locus tag: YNL185C
gene synonym: uL11m
product: mitochondrial 54S ribosomal protein YmL19
transcript id: NM_001183023.1
SIO_010081: YNL185C
subclass of: SO_0000673
so part of: YNL185C
location: complement(<292193..>292669)
location: region:292193-292669:-1
so has part: feature:292193-292669:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292193-292669:-1:exon

YNL185C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL11m
gene: MRPL19
locus tag: YNL185C
gene synonym: uL11m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL19
translation: MSQAAKNVIVKLIVGAGQAAPSPPVGPALGSKGIKAIDFCKEFNARSANYQPGVPVPVLITIKPDRTFTFEMKSPPTGYLLLKALKMDKGHGQPNVGTMLGSAPAKGPTRALGELSLKHVYEIAKIKKSDERHSLLEMEGIVKSIVGVAKSMGIKVVP
SIO_010081: YNL185C
subclass of: SO_0000673
so part of: YNL185C
location: complement(292193..292669)
location: region:292193-292669:-1
so has part: feature:292193-292669:-1:exon

NP_014214.1
type: Protein
SIO_000068: ncbiprotein

S000005129
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292193-292669:-1:exon

YNL184C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL184C
so part of: sequence
location: complement(<292557..>292883)
location: region:292557-292883:-1
so has part: feature:292557-292883:-1:exon
subclass of: SO_0000010

855537
type: Gene
SIO_000068: ncbigene

position:292557:-1
position: 292557
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292883:-1
position: 292883
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292557-292883:-1:exon

YNL184C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL184C
product: uncharacterized protein
transcript id: NM_001270758.1
SIO_010081: YNL184C
subclass of: SO_0000673
so part of: YNL184C
location: complement(<292557..>292883)
location: region:292557-292883:-1
so has part: feature:292557-292883:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292557-292883:-1:exon

YNL184C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL184C
note: hypothetical protein; expressed at both mRNA and protein levels
codon start: 1
product: uncharacterized protein
translation: MKRVTLIVLPRRQFPFLKFHSKEALESAVNLQLIRRKKSVNIQIDSVTFCIYFCLLYFRTLEYHRGTISLHNVTGSKKRDSKANSRSRPSGTITSRGARIGLQGYKSH
SIO_010081: YNL184C
subclass of: SO_0000673
so part of: YNL184C
location: complement(292557..292883)
location: region:292557-292883:-1
so has part: feature:292557-292883:-1:exon

NP_001257687.1
type: Protein
SIO_000068: ncbiprotein

S000005128
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292557-292883:-1:exon

YNL183C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NPR1
locus tag: YNL183C
so part of: sequence
location: complement(<293137..>295509)
location: region:293137-295509:-1
so has part: feature:293137-295509:-1:exon
subclass of: SO_0000010

855538
type: Gene
SIO_000068: ncbigene

position:293137:-1
position: 293137
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:295509:-1
position: 295509
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:293137-295509:-1:exon

YNL183C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NPR1
locus tag: YNL183C
product: serine/threonine protein kinase NPR1
transcript id: NM_001183021.1
SIO_010081: YNL183C
subclass of: SO_0000673
so part of: YNL183C
location: complement(<293137..>295509)
location: region:293137-295509:-1
so has part: feature:293137-295509:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:293137-295509:-1:exon

YNL183C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NPR1
locus tag: YNL183C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:19780626]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17095607]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17095607]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22118465]
experiment: EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:11500493]
experiment: EXISTENCE:mutant phenotype:GO:0022898 regulation of transmembrane transporter activity [PMID:2125693]
experiment: EXISTENCE:mutant phenotype:GO:0045806 negative regulation of endocytosis [PMID:22118465]
experiment: EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:23363605]
note: Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase NPR1
translation: MSSLTRLLQEKRKNETSNSSPRTSADTLTTTPESQSLDLHSRNKSSSHIGSVSNSSSSDRNRANVPVPGSVTTVTQIYSEEDSSSTAGSSLDDRNQFSSSFLNANFAHTASFYGTSAQSRDRFGSLINDQGTAGLSSHGGSFAAQNRITSRLSTTSHTSGRAIPSLSSSIPYSVPNSNKDNNSSNSNSSSLSSSWLETYAGGMPNNISAIDSNVISSPKVDSVEPRFVISKQKLQKASMDSNNANATQSRSISRSGSFSSQLGNFFFSKNSKESSNSNSAGMSFSANSNGPSPNIKNPNVTNGSTPIPKPIRARQSSIYSASRQPTGSYTDNFYGSPSSVHDHLPPSQSVPRSQHSSIGDLKRFFKKSSNSNLSSNSNNVIPNGSPLSSGIAVPSHSHSSSHFAAGNNSYSTSYNGNGDTIYSHSHGGSGIPFSKRYIKTGADLGAGAGGSVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIETIEIVYENDRILQVMEYCEYDLFAIVMSNKMSYEEICCCFKQILTGVQYLHSIGLAHRDLKLDNCVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPRPVDIWSSAIIFACMILKKFPWKIPKLRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGNIEEIMEDPWIRSIDMCHLVEDGLSFKVVRGEDHHHTQVDQSEAHIAGLEKKKKKQNNQ
SIO_010081: YNL183C
subclass of: SO_0000673
so part of: YNL183C
location: complement(293137..295509)
location: region:293137-295509:-1
so has part: feature:293137-295509:-1:exon

NP_014216.1
type: Protein
SIO_000068: ncbiprotein

S000005127
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:293137-295509:-1:exon

YNL182C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IPI3
locus tag: YNL182C
so part of: sequence
location: complement(<295960..>297627)
location: region:295960-297627:-1
so has part: feature:295960-297627:-1:exon
subclass of: SO_0000010

855539
type: Gene
SIO_000068: ncbigene

position:295960:-1
position: 295960
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:297627:-1
position: 297627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:295960-297627:-1:exon

YNL182C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IPI3
locus tag: YNL182C
product: chromatin-binding/pre-rRNA-processing protein IPI3
transcript id: NM_001183020.1
SIO_010081: YNL182C
subclass of: SO_0000673
so part of: YNL182C
location: complement(<295960..>297627)
location: region:295960-297627:-1
so has part: feature:295960-297627:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:295960-297627:-1:exon

YNL182C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IPI3
locus tag: YNL182C
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:22421151]
experiment: EXISTENCE:direct assay:GO:0097344 Rix1 complex [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]
experiment: EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]
note: Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p
codon start: 1
product: chromatin-binding/pre-rRNA-processing protein IPI3
translation: MDEQVIFTTNTSGTIASVHSFEQINLRQCSTQSRNSCVQVGNKYLFIAQAQKALINVYNLSGSFKRESVEQRLPLPEILKCLEVVENDGVQYDRIQGVNHNLPDFNLPYLLLGSTESGKLYIWELNSGILLNVKPMAHYQSITKIKSILNGKYIITSGNDSRVIIWQTVDLVSASNDDPKPLCILHDHTLPVTDFQVSSSQGKFLSCTDTKLFTVSQDATIRCYDLSLIGSKKKQKANENDVSIGKTPVLLATFTTPYSIKSIVLDPADRACYIGTAEGCFSLNLFYKLKGNAIVNLLQSAGVNTVQKGRVFSLVQRNSLTGGENEDLDALYAMGQLVCENVLNSNVSCLEISMDGTLLLIGDTEGKVSIAEIYSKQIIRTIQTLTTSQDSVGEVTNLLTNPYRLERGNLLFEGESKGKQPSNNNGHNFMKIPNLQRVIFDGKNKGHLHDIWYQIGEPEAETDPNLALPLNDFNAYLEQVKTQESIFSHIGKVSSNVKVIDNKIDATSSLDSNAAKDEEITELKTNIEALTHAYKELRDMHEKLYEEHQQMLDKQ
SIO_010081: YNL182C
subclass of: SO_0000673
so part of: YNL182C
location: complement(295960..297627)
location: region:295960-297627:-1
so has part: feature:295960-297627:-1:exon

NP_014217.1
type: Protein
SIO_000068: ncbiprotein

S000005126
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:295960-297627:-1:exon

YNL181W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PBR1
locus tag: YNL181W
so part of: sequence
location: <298335..>299558
location: region:298335-299558:1
so has part: feature:298335-299558:1:exon
subclass of: SO_0000010

855540
type: Gene
SIO_000068: ncbigene

position:298335:1
position: 298335
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:299558:1
position: 299558
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298335-299558:1:exon

YNL181W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PBR1
locus tag: YNL181W
product: putative oxidoreductase
transcript id: NM_001183019.2
SIO_010081: YNL181W
subclass of: SO_0000673
so part of: YNL181W
location: <298335..>299558
location: region:298335-299558:1
so has part: feature:298335-299558:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298335-299558:1:exon

YNL181W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PBR1
locus tag: YNL181W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591|PMID:14562095|PMID:26928762]
note: Putative oxidoreductase; required for cell viability
codon start: 1
product: putative oxidoreductase
translation: MPLNIIGTALLDGTDKIPYYQTIKKVAPYVLATGAIKYWSRGPSNTWERKLHGKVYLVTGATSQGMGTSVAYKMAELGAQLIILTREVDEWVTEWCEELREKTKNELIFVEKCDLSNLWEIRKFATSWLDNSPPRRLDGVIVMSGDMEPWGIPKISLPQRRSSKDGLELQIATNYVAIFHLLNLLQPSFKAQPPDRDVRIILATCWLQVVGDINIEDPLWQNAKYKSALKFFASSKLQLGLSMMELQRRLTEDIKNQKTNGAERTGKNVTITMVQPGTMRSNSLRRVISNGSVVLLIILYCILLYPILWLFTKSGRRGDQSFLYALMTPELEEVNLKDTKVKYISDCSIVKFARKEFDDEELQKKLFDNTERDILQLEKKVAAKRNANKTGNQNSKKKSQNKSRKDD
SIO_010081: YNL181W
subclass of: SO_0000673
so part of: YNL181W
location: 298335..299558
location: region:298335-299558:1
so has part: feature:298335-299558:1:exon

NP_014218.2
type: Protein
SIO_000068: ncbiprotein

S000005125
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298335-299558:1:exon

YNL180C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNS0
gene: RHO5
locus tag: YNL180C
gene synonym: YNS0
so part of: sequence
location: complement(<299654..>300649)
location: region:299654-300649:-1
so has part: feature:299654-300649:-1:exon
subclass of: SO_0000010

855541
type: Gene
SIO_000068: ncbigene

position:299654:-1
position: 299654
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300649:-1
position: 300649
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:299654-300649:-1:exon

YNL180C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNS0
gene: RHO5
locus tag: YNL180C
gene synonym: YNS0
product: Rho family GTPase RHO5
transcript id: NM_001183018.1
SIO_010081: YNL180C
subclass of: SO_0000673
so part of: YNL180C
location: complement(<299654..>300649)
location: region:299654-300649:-1
so has part: feature:299654-300649:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:299654-300649:-1:exon

YNL180C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNS0
gene: RHO5
locus tag: YNL180C
gene synonym: YNS0
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:18216266]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11591390]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18216266]
experiment: EXISTENCE:direct assay:GO:0012505 endomembrane system [PMID:18216266]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18216266]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18216266]
note: Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; necessary for oxidant and ramped heat stress-induced cell death; ortholog of mammalian RAC1
codon start: 1
product: Rho family GTPase RHO5
translation: MRSIKCVIIGDGAVGKTSLLISYTTNSFPTDYVPTVFDNYSTTIAIPNGTASSPLELDNGNDKRGSLSSASSSPSTDRKLYKINLWDTAGQEDYDRLRPLCYPQTDIFLICFSVSEHASFANVTEKWLPELKQTSNIEGTSLYTKLGKYPILLVGTKSDLRDDPATQKKLQEANSDYVSQEEIDELVQRCGFMGYTECSAATQAGVREVFEQAVRYAIYEPESPNQKSANHTLTDELTTATTNTNGDKNIREQKQQPHHNNSTDSTLPKGSLQQEKEALNIKPTKKGQKDKIHEQSKSKGSKIASNNHHNKQAKPKTRNDKKKKKSKCVIL
SIO_010081: YNL180C
subclass of: SO_0000673
so part of: YNL180C
location: complement(299654..300649)
location: region:299654-300649:-1
so has part: feature:299654-300649:-1:exon

NP_014219.1
type: Protein
SIO_000068: ncbiprotein

S000005124
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:299654-300649:-1:exon

YNL178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SUF14
gene: RPS3
locus tag: YNL178W
gene synonym: SUF14
so part of: sequence
location: <302680..>303402
location: region:302680-303402:1
so has part: feature:302680-303402:1:exon
subclass of: SO_0000010

855543
type: Gene
SIO_000068: ncbigene

position:302680:1
position: 302680
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:303402:1
position: 303402
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302680-303402:1:exon

YNL178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SUF14
gene: RPS3
locus tag: YNL178W
gene synonym: SUF14
product: ribosomal 40S subunit protein S3
transcript id: NM_001183016.3
SIO_010081: YNL178W
subclass of: SO_0000673
so part of: YNL178W
location: <302680..>303402
location: region:302680-303402:1
so has part: feature:302680-303402:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:302680-303402:1:exon

YNL178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SUF14
gene: RPS3
locus tag: YNL178W
gene synonym: SUF14
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:11561734]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916|PMID:385049|PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661]
experiment: EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:28223523]
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:28956756]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]
experiment: EXISTENCE:physical interaction:GO:0034236 protein kinase A catalytic subunit binding [PMID:22899713]
note: Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3
codon start: 1
product: ribosomal 40S subunit protein S3
translation: MVALISKKRKLVADGVFYAELNEFFTRELAEEGYSGVEVRVTPTKTEVIIRATRTQDVLGENGRRINELTLLVQKRFKYAPGTIVLYAERVQDRGLSAVAQAESMKFKLLNGLAIRRAAYGVVRYVMESGAKGCEVVVSGKLRAARAKAMKFADGFLIHSGQPVNDFIDTATRHVLMRQGVLGIKVKIMRDPAKSRTGPKALPDAVTIIEPKEEEPILAPSVKDYRPAEETEAQAEPVEA
SIO_010081: YNL178W
subclass of: SO_0000673
so part of: YNL178W
location: 302680..303402
location: region:302680-303402:1
so has part: feature:302680-303402:1:exon

NP_014221.3
type: Protein
SIO_000068: ncbiprotein

S000005122
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302680-303402:1:exon

YNL177C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL22m
gene: MRPL22
locus tag: YNL177C
gene synonym: uL22m
so part of: sequence
location: complement(<303686..>304615)
location: region:303686-304615:-1
so has part: feature:303686-304615:-1:exon
subclass of: SO_0000010

855544
type: Gene
SIO_000068: ncbigene

position:303686:-1
position: 303686
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:304615:-1
position: 304615
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:303686-304615:-1:exon

YNL177C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL22m
gene: MRPL22
locus tag: YNL177C
gene synonym: uL22m
product: mitochondrial 54S ribosomal protein YmL22
transcript id: NM_001183015.2
SIO_010081: YNL177C
subclass of: SO_0000673
so part of: YNL177C
location: complement(<303686..>304615)
location: region:303686-304615:-1
so has part: feature:303686-304615:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:303686-304615:-1:exon

YNL177C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL22m
gene: MRPL22
locus tag: YNL177C
gene synonym: uL22m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL22
translation: MNFHTARISQVGVISRALLSSVSRRWIHVTPISLNNSGGSLFGSITENKPKEGKNRGDEDAGSFSNRLAIASDSSGEAPEVNRDSITIENDKLLQQHIISLQQPEQLASQSLLSPLKREIYEANCKINGGFYKKDTIVKLPNSSERYKLKLTKREIEVLEPSVYAQSYRIKSSMKKATLLLRLLGGLDVMKAISQCHFSNKKIAREVAELLQKGVKDGQKLGLKPEDLYISQIWTGSDGFWRKRVEFKARTRIGIISHPYIHVRCILRTKSVTKRRLAYEAHLKEQKRAPWVQLGDKPIRGVTGGVYKW
SIO_010081: YNL177C
subclass of: SO_0000673
so part of: YNL177C
location: complement(303686..304615)
location: region:303686-304615:-1
so has part: feature:303686-304615:-1:exon

NP_014222.2
type: Protein
SIO_000068: ncbiprotein

S000005121
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:303686-304615:-1:exon

YNL176C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TDA7
locus tag: YNL176C
so part of: sequence
location: complement(<305070..>306980)
location: region:305070-306980:-1
so has part: feature:305070-306980:-1:exon
subclass of: SO_0000010

855545
type: Gene
SIO_000068: ncbigene

position:305070:-1
position: 305070
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:306980:-1
position: 306980
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:305070-306980:-1:exon

YNL176C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TDA7
locus tag: YNL176C
product: Tda7p
transcript id: NM_001183014.2
SIO_010081: YNL176C
subclass of: SO_0000673
so part of: YNL176C
location: complement(<305070..>306980)
location: region:305070-306980:-1
so has part: feature:305070-306980:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:305070-306980:-1:exon

YNL176C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TDA7
locus tag: YNL176C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]
note: Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication
codon start: 1
product: Tda7p
translation: MNSNSTIGRTTLGESDTISLSFSEPSSSLNSRSTDVVFASTSTLVPQQGSLTSLPPVSSTATPTYYSTSLTYDETLHTSIDVSSTSTLVSSTDSSSSSEQDTYSSQYDPATSSYSIITPSMSIFSSTSPMSSSSSITSEWSSLTSTTPTLSSSATSLSSSWSSLSSPSSLLVSSSLSLSLSSSYSDTKLFSFDSRSSIFSPSTPTVISPSYTYLSSISATSFQISTTSELSSSWFSTISSPSTISNKDTTFPSSSRNTSTSFYSSSLSSTNDFSTISKSSKLSPSASSSTVSISTISVPTSSSVSSSSSKVPSNRPSSSSSSDDTTSAYSSTYTFQSLQSTTSSSIPPTTQTPSTSTISTSPIPTSSQVFNTVAISSSEDSKTIYYFYTQTYDITDSSTTFVTGLPTTIAVAKSEVTSFSAPSSTITADMSFYQHWLDGSLDNNKNQGTSKTNTGTIVGSVVGSVGGILICVLVVWFMLVRKRKAKRHFKENDSFCHEIGRRTGFPTTAQAKEASLQAQDSGSQQRNTETASANNPFSNEFNFKARGNPPPVPPPRNVTAMNGSFQNMRSNFMDQENRFSYGSSFTYSSLGSSTQGGFSTLSSNSIRLGRGLDNDISHDERNTVQNNSQGFLREII
SIO_010081: YNL176C
subclass of: SO_0000673
so part of: YNL176C
location: complement(305070..306980)
location: region:305070-306980:-1
so has part: feature:305070-306980:-1:exon

NP_014223.2
type: Protein
SIO_000068: ncbiprotein

S000005120
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:305070-306980:-1:exon

YNL175C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP13
locus tag: YNL175C
so part of: sequence
location: complement(<307401..>308612)
location: region:307401-308612:-1
so has part: feature:307401-308612:-1:exon
subclass of: SO_0000010

855547
type: Gene
SIO_000068: ncbigene

position:307401:-1
position: 307401
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:308612:-1
position: 308612
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307401-308612:-1:exon

YNL175C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP13
locus tag: YNL175C
product: Nop13p
transcript id: NM_001183013.2
SIO_010081: YNL175C
subclass of: SO_0000673
so part of: YNL175C
location: complement(<307401..>308612)
location: region:307401-308612:-1
so has part: feature:307401-308612:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307401-308612:-1:exon

YNL175C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP13
locus tag: YNL175C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11452019|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030684 preribosome [PMID:17922018]
note: Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress
codon start: 1
product: Nop13p
translation: MSETELSKEDAVTKKDNEEQVKKALLDPTKKRKAEDEIEIDLKSSIPLSKKQKRLLRRGKVTLEELNAKYNIDPKSIEEYKEDAEKKKSGASEKDAQGEESTINTPTGDESGEVVKKKKKDENKYGVWIGNLSFDTTKDDLVRFFIAKTKDNEDEKSRVTEQDITRLSMPRVAAKNSNAMKNKGFCYMFFKNVEQMKAVLELSESHLNGRNMLIKDSENYSGRPDKDDLVAMSKNPPSRILFVGNLSFDVTDDLLRKHFQHCGDIVKIRMATFEDSGKCKGFAFIDFKNEEGSTNALKDKSCRKIAGRPLRMEYGEDRSKRQVRKKVENVSRNNSSSFDISNNKGYDRAGQDNGSKPEYKRSNANRRPPVDSNNRTKSSVALATAQRGSAAIVPSQGKKVKFD
SIO_010081: YNL175C
subclass of: SO_0000673
so part of: YNL175C
location: complement(307401..308612)
location: region:307401-308612:-1
so has part: feature:307401-308612:-1:exon

NP_014224.2
type: Protein
SIO_000068: ncbiprotein

S000005119
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307401-308612:-1:exon

YNL173C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDG1
locus tag: YNL173C
so part of: sequence
location: complement(<308957..>310057)
location: region:308957-310057:-1
so has part: feature:308957-310057:-1:exon
subclass of: SO_0000010

855548
type: Gene
SIO_000068: ncbigene

position:308957:-1
position: 308957
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:310057:-1
position: 310057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:308957-310057:-1:exon

YNL173C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDG1
locus tag: YNL173C
product: Mdg1p
transcript id: NM_001183011.1
SIO_010081: YNL173C
subclass of: SO_0000673
so part of: YNL173C
location: complement(<308957..>310057)
location: region:308957-310057:-1
so has part: feature:308957-310057:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:308957-310057:-1:exon

YNL173C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDG1
locus tag: YNL173C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8914522|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19064668]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8914522]
note: Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication
codon start: 1
product: Mdg1p
translation: MQSSLPQFTFKWPKGPEAIILTGTFDDWKGTLPMVKDPSGAFEITLPVTFDSPSSKFYFKFIVDGQWLPSKDYKVNIDEGVENNFITEEDVIKQRENGSSTLVPESAGLAVSKNAPLIEPEAEKRAKKLRKFKIKRVIKTNKQTGERSIFSQEVVELPDSEDETQQVNKTGKNADGLSGTTTIIENNVGVNEEKAIKPYEENHPKVNLVKSEGYVTDGLGKTQSSESRLYELSAEDLEKEEEEEDEDKGGGKDTSTSADAEASEDQNKEPLSKSAKFEKPEEKVPVSSITSHAKETSVKPTGKVATETQTYETKQGAPTAAAKKIEAKKATRPSKPKGTKETPNKGVQKNPAKNGGFFKKLAQLLK
SIO_010081: YNL173C
subclass of: SO_0000673
so part of: YNL173C
location: complement(308957..310057)
location: region:308957-310057:-1
so has part: feature:308957-310057:-1:exon

NP_014226.1
type: Protein
SIO_000068: ncbiprotein

S000005117
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:308957-310057:-1:exon

YNL172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APC1
locus tag: YNL172W
so part of: sequence
location: <310636..>315882
location: region:310636-315882:1
so has part: feature:310636-315882:1:exon
subclass of: SO_0000010

855549
type: Gene
SIO_000068: ncbigene

position:310636:1
position: 310636
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315882:1
position: 315882
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310636-315882:1:exon

YNL172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APC1
locus tag: YNL172W
product: anaphase promoting complex subunit 1
transcript id: NM_001183010.4
SIO_010081: YNL172W
subclass of: SO_0000673
so part of: YNL172W
location: <310636..>315882
location: region:310636-315882:1
so has part: feature:310636-315882:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310636-315882:1:exon

YNL172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APC1
locus tag: YNL172W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0007091 metaphase/anaphase transition of mitotic cell cycle [PMID:8895471]
experiment: EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:8895471]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473|PMID:8895471]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]
note: Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
codon start: 1
product: anaphase promoting complex subunit 1
translation: MTSKPSTRNDYLPRETHNGEYTGDSPEWQLQINITNKIGGINGDIWLSRDGRSVKWCIEDQCLRQFTYNQKIIKAGYIDFEKTPDCFVVVLSDIAHVYMLKNGGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKPIEFDLKHKYITLTDPMAPFGLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVFLDRNSKVLRFYYSRILSSDQSRKGELTISSTKKTGLDAAGNSQKSGGISKDLRKFSHLTRRSTSINSNSHDFNAAERVLSGNVGNASGRTDIFALPSSCSRRSLSATLDRMGNNIAPTNRAAPSGFFDSSSANTATHSNITPVSQPMQQQQQEYLNQTATSSKDIVLTEISSLKLPDDIIFTSRRLSSILSKLKFLSLRFERREGLLIFHEPTHFCKIWLIDLLPDVLDSIPFKIYGNSPQNMIRLENLKLKEPSRIQAMYIHELLESCLILVSEGQNKEEYKACLYDPFVKITSPSKNISEELTKQNSLPSLQKLFPYPETSFTKLCFEAVKYITSPAFNISFIFLWQSAYSILLSRANDDVVGGLKMEHDAFSLVLSLLILPIPSSSAQEYQEYKEIYERDLFQHLKQDSEITSSVLPRIVIGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSYYVPKMDSESKTFLHPREQNSTFFHPLDEPPSITKSLYSITENSSIPLCPFISFSRLVATDTQVELRITPRSFKILGLYELVHSPNFLPDYVLGILSSFKVDKDELQTYPLGILVPLQNILKILEDKLSEVRDNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVPLAKNRSSLSKKPSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDKRFTHVVSLLAYYRPTKTQFFTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKPISTQKWVIQPLNLISVFPDDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGITGSWIAFNKPKELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSSSMKGSMDSKLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDSIFAQLVSLLNVNDEMVADEEYRLAAGISLGLINLGAGQTKLRKWDSSLLGLGDDLPEDVYDSSDVEQNVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFGISNMLKVDLKEILKANINTRPELLMYREWASNMILWEFIGDDLSFIMKDVDIGVKFSELNTDLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFLPLYQYPGKQNLDFRLTISVINVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVSGVTQVTSNTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKFISTNLALGFLFLGSGQYALNTSTLESIAFLSMSVLPTYTTPHPLQELKHFWSMAVEPRCLVIKDISTGDAVNNVPIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYFPLEVNFTKDYSASDFFSGGTIIYIQRKSESVFENKASFRNVEDIHVALKRKAAESKNYSRLNLKNEQGNTTSSQLVESLGIQDLTMVELDTLLSAGNNTALTDSESYNLGLLCSDKNSGDILDCQLELWYKSFGPHDE
SIO_010081: YNL172W
subclass of: SO_0000673
so part of: YNL172W
location: 310636..315882
location: region:310636-315882:1
so has part: feature:310636-315882:1:exon

NP_014227.4
type: Protein
SIO_000068: ncbiprotein

S000005116
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310636-315882:1:exon

YNL169C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSD1
locus tag: YNL169C
so part of: sequence
location: complement(<316169..>317671)
location: region:316169-317671:-1
so has part: feature:316169-317671:-1:exon
subclass of: SO_0000010

855552
type: Gene
SIO_000068: ncbigene

position:316169:-1
position: 316169
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:317671:-1
position: 317671
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316169-317671:-1:exon

YNL169C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSD1
locus tag: YNL169C
product: phosphatidylserine decarboxylase 1
transcript id: NM_001183007.1
SIO_010081: YNL169C
subclass of: SO_0000673
so part of: YNL169C
location: complement(<316169..>317671)
location: region:316169-317671:-1
so has part: feature:316169-317671:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316169-317671:-1:exon

YNL169C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSD1
locus tag: YNL169C
EC number: 4.1.1.65
experiment: EXISTENCE:direct assay:GO:0004609 phosphatidylserine decarboxylase activity [PMID:23124206]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23124206]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:34818062]
experiment: EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:6427211]
experiment: EXISTENCE:direct assay:GO:0016540 protein autoprocessing [PMID:25829489]
experiment: EXISTENCE:direct assay:GO:0140042 lipid droplet formation [PMID:34818062]
experiment: EXISTENCE:mutant phenotype:GO:0004609 phosphatidylserine decarboxylase activity [PMID:8407984]
experiment: EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:30926815]
experiment: EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:23045528]
experiment: EXISTENCE:mutant phenotype:GO:0010954 positive regulation of protein processing [PMID:23045528]
note: Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed
codon start: 1
product: phosphatidylserine decarboxylase 1
translation: MSIMPVKNALAQGRTLLMGRMPAVKFSTRMQLRNRTAVLWNRKFSTRLFVQQRRSSGEIVDRAKAAAANSGRKQVSMKWVVLTSFTIVLGTILLVSRNDSTEEDATEGKKGRRTRKIKIFNNNWLFFCYSTLPLNAMSRLWGQVNSLTLPIWVRPWGYRLYSFLFGVNLDEMEDPDLTHYANLSEFFYRNIKPGTRPVAQGEDVIASPSDGKILQVGIINSETGEIEQVKGMTYSIKEFLGTHSHPLMSKSASSLDLTSDEEKHREFARVNRIQLAGSEDTEQPLLNFKNEGDQSVREFKPSVSKNIHLLSQLSLNYFSNGFSCSEPHDTELFFAVIYLAPGDYHHFHSPVDWVCKVRRHFPGDLFSVAPYFQRNFPNLFVLNERVALLGSWKYGFFSMTPVGATNVGSIKLNFDQEFVTNSKSDKHLEPHTCYQAVYENASKILGGMPLVKGEEMGGFELGSTVVLCFEAPTEFKFDVRVGDKVKMGQKLGIIGKNDLK
SIO_010081: YNL169C
subclass of: SO_0000673
so part of: YNL169C
location: complement(316169..317671)
location: region:316169-317671:-1
so has part: feature:316169-317671:-1:exon

NP_014230.1
type: Protein
SIO_000068: ncbiprotein

S000005113
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316169-317671:-1:exon

YNL168C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP41
locus tag: YNL168C
so part of: sequence
location: complement(<318030..>318809)
location: region:318030-318809:-1
so has part: feature:318030-318809:-1:exon
subclass of: SO_0000010

855553
type: Gene
SIO_000068: ncbigene

position:318030:-1
position: 318030
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:318809:-1
position: 318809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318030-318809:-1:exon

YNL168C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP41
locus tag: YNL168C
product: Fmp41p
transcript id: NM_001183006.1
SIO_010081: YNL168C
subclass of: SO_0000673
so part of: YNL168C
location: complement(<318030..>318809)
location: region:318030-318809:-1
so has part: feature:318030-318809:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:318030-318809:-1:exon

YNL168C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP41
locus tag: YNL168C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]
note: hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Fmp41p
translation: MSYNYLKAARKIICIGRNYAAHIKELNNSTPKQPFFFLKPTSSIVTPLSSSLVKTTRPANSTFNGLNEDGTNPGPIFIPRGVKVHHEIELALIVSKHLSNVTKMKPEEVYDSISGVALALDLTARNVQDEAKKKGLPWTISKGFDTFMPISAIVSREKFSSYKSNLQDIFRVKCSVNGQLRQDGGTNLMLHPLHKILQHISTMISLEPGDIILTGTPAGVGELKPGDRVHCELLQNNDNIVDMNFECENRPGPYEFRET
SIO_010081: YNL168C
subclass of: SO_0000673
so part of: YNL168C
location: complement(318030..318809)
location: region:318030-318809:-1
so has part: feature:318030-318809:-1:exon

NP_014231.1
type: Protein
SIO_000068: ncbiprotein

S000005112
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:318030-318809:-1:exon

YNL167C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACR1
gene: SKO1
locus tag: YNL167C
gene synonym: ACR1
so part of: sequence
location: complement(<319416..>321359)
location: region:319416-321359:-1
so has part: feature:319416-321359:-1:exon
subclass of: SO_0000010

855554
type: Gene
SIO_000068: ncbigene

position:319416:-1
position: 319416
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321359:-1
position: 321359
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319416-321359:-1:exon

YNL167C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACR1
gene: SKO1
locus tag: YNL167C
gene synonym: ACR1
product: Sko1p
transcript id: NM_001183005.1
SIO_010081: YNL167C
subclass of: SO_0000673
so part of: YNL167C
location: complement(<319416..>321359)
location: region:319416-321359:-1
so has part: feature:319416-321359:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:319416-321359:-1:exon

YNL167C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACR1
gene: SKO1
locus tag: YNL167C
gene synonym: ACR1
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177|PMID:11500510|PMID:12086627|PMID:1437546|PM ID:1448073|PMID:9858577]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:11113177|PMID:1437546|PMID:1448073|PMID:9858577]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11500510]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11500510]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12086627]
experiment: EXISTENCE:direct assay:GO:0051019 mitogen-activated protein kinase binding [PMID:11230135]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135|PMID:11500510]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]
experiment: EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:11230135]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11113177|PMID:11230135]
experiment: EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10825197|PMID:11113177|PMID:11230135|PMID:1437546|PM ID:1448073|PMID:9858577]
experiment: EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:12086627]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:11113177|PMID:1437546|PMID:1448073|PMID:9858577]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]
experiment: EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:11230135]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11113177|PMID:11230135|PMID:12086627|PMID:10825197]
experiment: EXISTENCE:mutant phenotype:GO:0051019 mitogen-activated protein kinase binding [PMID:12086627]
experiment: EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]
note: Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
codon start: 1
product: Sko1p
translation: MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPSLPKELSRNNSTSTITQHSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQRPTIISPPILTPGGSKRLPPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSSTSGSLYPNSSSPSGTSLIRQPRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNESNIRTGLTPGILTQSYNYPVLPSINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTVNGTPLTPGLSSLLNLPSTGVLANPVFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAVKMDNPAEFNAIEHSAHNHKENENLTTQIENNDQFNNKTRKRKRRMSSTSSTSKASRKNSISRKNSAVTTAPAQKDDVENNKISNNVTLDENEEQERKRKEFLERNRVAASKFRKRKKEYIKKIENDLQFYESEYDDLTQVIGKLCGIIPSSSSNSQFNVNVSTPSSSSPPSTSLIALLESSISRSDYSSAMSVLSNMKQLICETNFYRRGGKNPRDDMDGQEDSFNKDTNVVKSENAGYPSVNSRPIILDKKYSLNSGANISKSNTTTNNVGNSAQNIINSCYSVTNPLVINANSDTHDTNKHDVLSTLPHNN
SIO_010081: YNL167C
subclass of: SO_0000673
so part of: YNL167C
location: complement(319416..321359)
location: region:319416-321359:-1
so has part: feature:319416-321359:-1:exon

NP_014232.1
type: Protein
SIO_000068: ncbiprotein

S000005111
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:319416-321359:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1415; Autonomously Replicating Sequence
so part of: sequence
location: 321921..322213
location: region:321921-322213:1
so has part: feature:321921-322213:1:region

S000118385
type: SGD
SIO_000068: sgd

position:321921:1
position: 321921
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:322213:1
position: 322213
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321921-322213:1:region

YNL166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BNI5
locus tag: YNL166C
so part of: sequence
location: complement(<322219..>323565)
location: region:322219-323565:-1
so has part: feature:322219-323565:-1:exon
subclass of: SO_0000010

855555
type: Gene
SIO_000068: ncbigene

position:322219:-1
position: 322219
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:323565:-1
position: 323565
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:322219-323565:-1:exon

YNL166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BNI5
locus tag: YNL166C
product: Bni5p
transcript id: NM_001183004.1
SIO_010081: YNL166C
subclass of: SO_0000673
so part of: YNL166C
location: complement(<322219..>323565)
location: region:322219-323565:-1
so has part: feature:322219-323565:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:322219-323565:-1:exon

YNL166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BNI5
locus tag: YNL166C
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:12215547]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12215547|PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:25971666]
experiment: EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:12215547]
experiment: EXISTENCE:mutant phenotype:GO:0072741 protein localization to cell division site [PMID:21173112]
experiment: EXISTENCE:physical interaction:GO:0032035 myosin II tail binding [PMID:21173112]
note: Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis
codon start: 1
product: Bni5p
translation: MGLDQDKIKKRLSQIEIDINQMNQMIDENLQLVEPAEDEAVEDNVKDTGVVDAVKVAETALFSGNDGADSNPGDSAQVEEHKTAQVHIPTENEANKSTDDPSQLSVTQPFIAKEQITHTAIAIGDSYNSFVANSAGNEKAKDSCTENKEDGTVNIDQNRGEADVEIIENNDDEWEDEKSDVEEGRVDKGTEENSEIESFKSPMPQNNTLGGENKLDAELVLDKFSSANKDLDIQPQTIVVGGDNEYNHESSRLADQTPHDDNSENCPNRSGGSTPLDSQTKIFIPKKNSKEDGTNINHFNSDGDGQKKMANFETRRPTNPFRVISVSSNSNSRNGSRKSSLNKYDSPVSSPITSASELGSIAKLEKRHDYLSMKCIKLQKEIDYLNKMNAQGSLSMEDGKRLHRAVVKLQEYLDKKTKEKYEVGVLLSRHLRKQIDRGENGQFWIGTK
SIO_010081: YNL166C
subclass of: SO_0000673
so part of: YNL166C
location: complement(322219..323565)
location: region:322219-323565:-1
so has part: feature:322219-323565:-1:exon

NP_014233.1
type: Protein
SIO_000068: ncbiprotein

S000005110
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:322219-323565:-1:exon

YNL165W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL165W
so part of: sequence
location: <323832..>325052
location: region:323832-325052:1
so has part: feature:323832-325052:1:exon
subclass of: SO_0000010

855556
type: Gene
SIO_000068: ncbigene

position:323832:1
position: 323832
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:325052:1
position: 325052
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323832-325052:1:exon

YNL165W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL165W
product: uncharacterized protein
transcript id: NM_001183003.3
SIO_010081: YNL165W
subclass of: SO_0000673
so part of: YNL165W
location: <323832..>325052
location: region:323832-325052:1
so has part: feature:323832-325052:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323832-325052:1:exon

YNL165W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL165W
note: hypothetical protein; YNL165W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MDRVRSLIGNRRGRRHNRQHPPYPHSGSPSTVNLLGANGYGDDQSTIFARENESLETSANEGDDSADAATLNTAVSEGSTIGDLQRQGYVNRAPRFTSERAMPFVSVLLQRGFFAFPSEESLQLFLHNKRKLDNIDPKRGLGLPLFHAISLNLVKSLFSDQNTPVMRIYKYVMIDSQCDKPPLNSEVVSRINENVSIYKYEFCTILKKMESHNFSSRVEHDFIFHRKDEPDVHIPMINYNQRKNADTAIHGLNLRWYGTTSLASPFGSNSINLLVLDDTMASYMNQQTIEEFDSYSRSRPTRPLGYLPVWARYTDDKVSVIPKKRTLRVATLYLQETDSFDDGSSLTSTNYTEMGSNIIENVPWDSQILTCMCMLLHEYESRKEKRHTAWGSSTTYMLNGPAGLLM
SIO_010081: YNL165W
subclass of: SO_0000673
so part of: YNL165W
location: 323832..325052
location: region:323832-325052:1
so has part: feature:323832-325052:1:exon

NP_014234.3
type: Protein
SIO_000068: ncbiprotein

S000005109
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323832-325052:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1416; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 325054..325267
location: region:325054-325267:1
so has part: feature:325054-325267:1:region

S000130142
type: SGD
SIO_000068: sgd

position:325054:1
position: 325054
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:325267:1
position: 325267
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325054-325267:1:region

YNL164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IBD2
locus tag: YNL164C
so part of: sequence
location: complement(<325265..>326320)
location: region:325265-326320:-1
so has part: feature:325265-326320:-1:exon
subclass of: SO_0000010

855557
type: Gene
SIO_000068: ncbigene

position:325265:-1
position: 325265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326320:-1
position: 326320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325265-326320:-1:exon

YNL164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IBD2
locus tag: YNL164C
product: Ibd2p
transcript id: NM_001183002.1
SIO_010081: YNL164C
subclass of: SO_0000673
so part of: YNL164C
location: complement(<325265..>326320)
location: region:325265-326320:-1
so has part: feature:325265-326320:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325265-326320:-1:exon

YNL164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IBD2
locus tag: YNL164C
experiment: EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]
note: Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
codon start: 1
product: Ibd2p
translation: MTPTNQSSGTTNASVEVLSEDGPMPINVMMQEGVKALTKILSNQLQDRQAFQNAPHAMQFVIRNGGKALSNARLEELKDALPKMDSLSLEDELAKIDGQSAYHIDSAEEKETFESKIGQIASRNSADFIIEEDLQNILDDDLKDSELNLDGEEAEIIFDYESQELDTPDGIGEKISQMIESVLPGGFGSEEQGGLRTVTNVEDLDVAEEVTDIDHDTVDAARLHGDGQHSISSRKHSRSKNSKKNGHVRRHDFYDESRDHKSCCPHHHYENLSKLRNYYYHDFEYISRTENRVPDFSVLVNESSPMCLFCEYYMVFGEPPRNMIKWYNRTFGYNRMPNPPRDEQDSRKRNR
SIO_010081: YNL164C
subclass of: SO_0000673
so part of: YNL164C
location: complement(325265..326320)
location: region:325265-326320:-1
so has part: feature:325265-326320:-1:exon

NP_014235.1
type: Protein
SIO_000068: ncbiprotein

S000005108
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325265-326320:-1:exon

YNL163C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EFL1
gene: RIA1
locus tag: YNL163C
gene synonym: EFL1
so part of: sequence
location: complement(<326741..>330073)
location: region:326741-330073:-1
so has part: feature:326741-330073:-1:exon
subclass of: SO_0000010

855558
type: Gene
SIO_000068: ncbigene

position:326741:-1
position: 326741
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330073:-1
position: 330073
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326741-330073:-1:exon

YNL163C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EFL1
gene: RIA1
locus tag: YNL163C
gene synonym: EFL1
product: GTPase RIA1
transcript id: NM_001183001.1
SIO_010081: YNL163C
subclass of: SO_0000673
so part of: YNL163C
location: complement(<326741..>330073)
location: region:326741-330073:-1
so has part: feature:326741-330073:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326741-330073:-1:exon

YNL163C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EFL1
gene: RIA1
locus tag: YNL163C
gene synonym: EFL1
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11779510]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11779510]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:11779510]
note: Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
codon start: 1
product: GTPase RIA1
translation: MPRVESETYKRLQNDPSCIRNICIVAHVDHGKTSLSDSLLASNGIISQRLAGKIRFLDARPDEQLRGITMESSAISLYFRVLRKQEGSDEPLVSEHLVNLIDSPGHIDFSSEVSAASRLCDGAVVLVDVVEGVCSQTVTVLRQCWTEKLKPILVLNKIDRLITELQLTPQEAYIHLSKVIEQVNSVIGSFFANERQLDDLFWREQLEKNENAEYIEKDDSGIYFNPTDNNVIFASAIDGWGFNIGQLAKFYEQKLGAKRENLQKVLWGDFYMDPKTKKIINNKGLKGRSLKPLFTSLILENIWKIYQNIITSRDSEMVEKIAKTLNIKLLARDLRSKDDKQLLRTIMGQWLPVSTAVLLTVIEKLPSPLESQTDRLNTILVSESDTAAMDPRLLKAMKTCDKEGPVSAYVSKMLSIPREELPVESKRIASSDELMERSRKAREEALNAAKHAGMVENMAMMDLNDNSKNTSDLYKRAKDTVMTPEVGEQTKPKPSRNNDVFCVVSEPSSALDLEFEYEGEDDSDSQDNFGLDFVPTDIDPNDPLSSMFEYEEEDPLLESIKQISEDVNDEVDDIFDEKEECLVAFARIYSGTLRVGQEISVLGPKYDPKCPEEHIETAIITHLYLFMGKELVPLDVCPSGNIVGIRGLAGKVLKSGTLIEKGVQGVNLAGVNFHFTPIVRVAVEPANPVEMSKLVRGLKLLDQADPCVHTYVENTGEHILCTAGELHLERCLKDLTERFAGIEITHSEPAIPYRETFLSASDMNPPQNSQLGRGVHELLLSQYKITFRTFPLSGKVTDFLSQHQNSIKNILKTSTSSMDPVIESTGSSFLDKKSLLVAFEEVINQEEKSRELLSGFKVKLAGFGPSRVGCNILLSQDNLLGSLFEGTPAAFEYSDSIKNGFQLAVSEGPLANEPVQGMCVLVESVHKMSQDEIESIEDPRYQQHIVDLSGRLITSTRDAIHEAFLDWSPRIMWAIYSCDIQTSVDVLGKVYAVILQRHGKIISEEMKEGTPFFQIEAHVPVVEAFGLSEDIRKRTSGAAQPQLVFSGFECIDLDPFWVPTTEEELEELGDTADRENIARKHMNAIRRRKGLFIEEKVVENAEKQRTLKKN
SIO_010081: YNL163C
subclass of: SO_0000673
so part of: YNL163C
location: complement(326741..330073)
location: region:326741-330073:-1
so has part: feature:326741-330073:-1:exon

NP_014236.1
type: Protein
SIO_000068: ncbiprotein

S000005107
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326741-330073:-1:exon

YNL162W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL162W-A
so part of: sequence
location: <330329..>330547
location: region:330329-330547:1
so has part: feature:330329-330547:1:exon
subclass of: SO_0000010

855559
type: Gene
SIO_000068: ncbigene

position:330329:1
position: 330329
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330547:1
position: 330547
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330329-330547:1:exon

YNL162W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL162W-A
product: uncharacterized protein
transcript id: NM_001184490.1
SIO_010081: YNL162W-A
subclass of: SO_0000673
so part of: YNL162W-A
location: <330329..>330547
location: region:330329-330547:1
so has part: feature:330329-330547:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330329-330547:1:exon

YNL162W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL162W-A
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; identified by homology
codon start: 1
product: uncharacterized protein
translation: MSDKPDSQVFCPNCNERLQKCLVQQNYAIIICPSLVCGYPFNQREVLENLTYVDDNDVLKVAKKRLSSRSKP
SIO_010081: YNL162W-A
subclass of: SO_0000673
so part of: YNL162W-A
location: 330329..330547
location: region:330329-330547:1
so has part: feature:330329-330547:1:exon

NP_076906.1
type: Protein
SIO_000068: ncbiprotein

S000007624
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330329-330547:1:exon

YNL162W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL42A
locus tag: YNL162W
so part of: sequence
location: <331322..>332154
location: region:331322-332154:1
so has part: feature:331322-332154:1:exon
subclass of: SO_0000010

855560
type: Gene
SIO_000068: ncbigene

position:331322:1
position: 331322
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332154:1
position: 332154
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:331322-332154:1:exon

YNL162W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL42A
locus tag: YNL162W
product: ribosomal 60S subunit protein L42A
transcript id: NM_001183000.1
SIO_010081: YNL162W
subclass of: SO_0000673
so part of: YNL162W
location: join(<331322..331325,331838..>332154)
location: region:331322-332154:1
so has part: feature:331322-331325:1:exon
so has part: feature:331838-332154:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:331322-331325:1:exon

position:331325:1
position: 331325
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:331838-332154:1:exon

position:331838:1
position: 331838
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL162W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL42A
locus tag: YNL162W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L42A
translation: MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF
SIO_010081: YNL162W
subclass of: SO_0000673
so part of: YNL162W
location: join(331322..331325,331838..332154)
location: region:331322-332154:1
so has part: feature:331322-331325:1:exon
so has part: feature:331838-332154:1:exon

NP_014237.2
type: Protein
SIO_000068: ncbiprotein

S000005106
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:331322-331325:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:331838-332154:1:exon

YNL161W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CBK1
locus tag: YNL161W
so part of: sequence
location: <332597..>334867
location: region:332597-334867:1
so has part: feature:332597-334867:1:exon
subclass of: SO_0000010

855561
type: Gene
SIO_000068: ncbigene

position:332597:1
position: 332597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334867:1
position: 334867
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:332597-334867:1:exon

YNL161W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CBK1
locus tag: YNL161W
product: serine/threonine protein kinase CBK1
transcript id: NM_001182999.3
SIO_010081: YNL161W
subclass of: SO_0000673
so part of: YNL161W
location: <332597..>334867
location: region:332597-334867:1
so has part: feature:332597-334867:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:332597-334867:1:exon

YNL161W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CBK1
locus tag: YNL161W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10970846]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:18715118]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11747810|PMID:12196508]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10970846|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12196508]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10970846|PMID:11747810|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10970846|PMID:11259593|PMID:11747810|PMID:12196508|P MID:22842922]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:10970846]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11747810|PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:11259593|PMID:12972564]
experiment: EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:19962308]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11747810|PMID:12196508]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:11259593|PMID:12972564]
experiment: EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:12196508]
experiment: EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:11259593]
experiment: EXISTENCE:mutant phenotype:GO:0050708 regulation of protein secretion [PMID:30455324]
note: Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
codon start: 1
product: serine/threonine protein kinase CBK1
translation: MYNSSTNHHEGAPTSGHGYYMSQQQDQQHQQQQQYANEMNPYQQIPRPPAAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTDVPALNYPATPPPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLSPGQYSIESEYNQNLNGSSSSSPFHQPQTLRSNGSYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQNSRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLTKGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLPFIGYTYSRFDYLTRKNAL
SIO_010081: YNL161W
subclass of: SO_0000673
so part of: YNL161W
location: 332597..334867
location: region:332597-334867:1
so has part: feature:332597-334867:1:exon

NP_014238.3
type: Protein
SIO_000068: ncbiprotein

S000005105
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:332597-334867:1:exon

YNL160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YGP1
locus tag: YNL160W
so part of: sequence
location: <336545..>337609
location: region:336545-337609:1
so has part: feature:336545-337609:1:exon
subclass of: SO_0000010

855562
type: Gene
SIO_000068: ncbigene

position:336545:1
position: 336545
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337609:1
position: 337609
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:336545-337609:1:exon

YNL160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YGP1
locus tag: YNL160W
product: Ygp1p
transcript id: NM_001182998.1
SIO_010081: YNL160W
subclass of: SO_0000673
so part of: YNL160W
location: <336545..>337609
location: region:336545-337609:1
so has part: feature:336545-337609:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:336545-337609:1:exon

YNL160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YGP1
locus tag: YNL160W
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]
experiment: EXISTENCE:direct assay:GO:0070726 cell wall assembly [PMID:10234784]
note: Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; protein demonstrates amyloid properties in vivo; YGP1 has a paralog, SPS100, that arose from the whole genome duplication
codon start: 1
product: Ygp1p
translation: MKFQVVLSALLACSSAVVASPIENLFKYRAVKASHSKNINSTLPAWNGSNSSNVTYANGTNSTTNTTTAESSQLQIIVTGGQVPITNSSLTHTNYTRLFNSSSALNITELYNVARVVNETIQDKSSAGAVVVANAKSLEAVSFFFSIIFDTEKPIVVTEDSAYAIPVANNKNATKRGVLSVTSDKLVYSGVFTPPTACSYGAGLPVAIVDDQDEVKWFFDASKPTLISSDSIIRKEYSNFTTPYGLLENGVPIVPIVYDGGYSSSLIDSLSSAVQGLVVVSSGSTNSTSSTIESTEIPVVYAQANTPLNFIDNKDVPKNAVGAGYLSPIKAQILLSIAAVNGVTSKSALESIFP
SIO_010081: YNL160W
subclass of: SO_0000673
so part of: YNL160W
location: 336545..337609
location: region:336545-337609:1
so has part: feature:336545-337609:1:exon

NP_014239.1
type: Protein
SIO_000068: ncbiprotein

S000005104
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:336545-337609:1:exon

YNL159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASI2
locus tag: YNL159C
so part of: sequence
location: complement(<338478..>339347)
location: region:338478-339347:-1
so has part: feature:338478-339347:-1:exon
subclass of: SO_0000010

855563
type: Gene
SIO_000068: ncbigene

position:338478:-1
position: 338478
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339347:-1
position: 339347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:338478-339347:-1:exon

YNL159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASI2
locus tag: YNL159C
product: Asi2p
transcript id: NM_001182997.1
SIO_010081: YNL159C
subclass of: SO_0000673
so part of: YNL159C
location: complement(<338478..>339347)
location: region:338478-339347:-1
so has part: feature:338478-339347:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:338478-339347:-1:exon

YNL159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASI2
locus tag: YNL159C
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]
experiment: EXISTENCE:mutant phenotype:GO:0036369 transcription factor catabolic process [PMID:25253722]
experiment: EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]
note: Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids
codon start: 1
product: Asi2p
translation: MARPQNHRRSNWTERDDNDDYLFQRFLEESETRHSREPSPVTEQSQQELQQDVQQAIDGIFNSLRRNMSSTSNINRAANMDATTNGNGGINADTIRATNANTADSPFTARQQSPLRTFLRNLFILDYFIGLILFPFSVYNILRSGFNSMTFSENDFIIEIVGYWKFAKIFGSGGTTLIAYKDTGKLGLLGKFHNIIVFYSSPVIKHIMKSRDGNEPNLNWIRLMFAKAFELFVKVSTILIYLAYGVSGTVYMVTAGFFFVLCLLFTVIRRYKGVHRMLVSQRITGPGVF
SIO_010081: YNL159C
subclass of: SO_0000673
so part of: YNL159C
location: complement(338478..339347)
location: region:338478-339347:-1
so has part: feature:338478-339347:-1:exon

NP_014240.1
type: Protein
SIO_000068: ncbiprotein

S000005103
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:338478-339347:-1:exon

YNL158W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PGA1
locus tag: YNL158W
so part of: sequence
location: <339612..>340208
location: region:339612-340208:1
so has part: feature:339612-340208:1:exon
subclass of: SO_0000010

855564
type: Gene
SIO_000068: ncbigene

position:339612:1
position: 339612
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340208:1
position: 340208
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339612-340208:1:exon

YNL158W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PGA1
locus tag: YNL158W
product: Pga1p
transcript id: NM_001182996.1
SIO_010081: YNL158W
subclass of: SO_0000673
so part of: YNL158W
location: <339612..>340208
location: region:339612-340208:1
so has part: feature:339612-340208:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339612-340208:1:exon

YNL158W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PGA1
locus tag: YNL158W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17615295]
experiment: EXISTENCE:genetic interaction:GO:0000030 mannosyltransferase activity [PMID:17615295]
experiment: EXISTENCE:genetic interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]
experiment: EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:17615295]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17615295]
experiment: EXISTENCE:physical interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]
note: Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes
codon start: 1
product: Pga1p
translation: MVRPQNVHWFIATIVFFIGFVHANTESILYKVPHNFPLKKPRDSSTYARDVNLISSISLSGEAMSQITIEANTTDLELHNTTYIELADLQRDETYQIKVCWSAIHPISINNLQTITIPRFTEFQGTKSDYARILVTFQVLSDSYPSEHAMVPIQVSLITTRLGIPVDIYPTLIVMVLLVAGLVVTRAPHVLNDLLLKF
SIO_010081: YNL158W
subclass of: SO_0000673
so part of: YNL158W
location: 339612..340208
location: region:339612-340208:1
so has part: feature:339612-340208:1:exon

NP_014241.1
type: Protein
SIO_000068: ncbiprotein

S000005102
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339612-340208:1:exon

YNL157W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IGO1
locus tag: YNL157W
so part of: sequence
location: <340352..>340858
location: region:340352-340858:1
so has part: feature:340352-340858:1:exon
subclass of: SO_0000010

855565
type: Gene
SIO_000068: ncbigene

position:340352:1
position: 340352
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340858:1
position: 340858
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:340352-340858:1:exon

YNL157W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IGO1
locus tag: YNL157W
product: phosphatase regulator
transcript id: NM_001182995.1
SIO_010081: YNL157W
subclass of: SO_0000673
so part of: YNL157W
location: <340352..>340858
location: region:340352-340858:1
so has part: feature:340352-340858:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:340352-340858:1:exon

YNL157W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IGO1
locus tag: YNL157W
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:20471941]
experiment: EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919|PMID:23861665]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20471941|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:1905183 negative regulation of protein serine/threonine phosphatase activity [PMID:23273919|PMID:23861665]
experiment: EXISTENCE:genetic interaction:GO:0048255 mRNA stabilization [PMID:20471941]
experiment: EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:20471941]
experiment: EXISTENCE:genetic interaction:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]
experiment: EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:20471941|PMID:23273919]
experiment: EXISTENCE:genetic interaction:GO:1905184 positive regulation of protein serine/threonine phosphatase activity [PMID:23861665]
experiment: EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919]
experiment: EXISTENCE:mutant phenotype:GO:1905183 negative regulation of protein serine/threonine phosphatase activity [PMID:23273919]
note: Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication
codon start: 1
product: phosphatase regulator
translation: MSNENLSPNSSNPDLTKLNNGESGTIDTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDPINYGKNNLPLTNPSKLREDIIKRRISTCPSTASTAGVVDNATLIQKEGSISSGPPSSNNGTIGGGSTSSTPVGNHSSSSSSLYTESPIR
SIO_010081: YNL157W
subclass of: SO_0000673
so part of: YNL157W
location: 340352..340858
location: region:340352-340858:1
so has part: feature:340352-340858:1:exon

NP_014242.1
type: Protein
SIO_000068: ncbiprotein

S000005101
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:340352-340858:1:exon

YNL156C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSG2
locus tag: YNL156C
so part of: sequence
location: complement(<341069..>341968)
location: region:341069-341968:-1
so has part: feature:341069-341968:-1:exon
subclass of: SO_0000010

855566
type: Gene
SIO_000068: ncbigene

position:341069:-1
position: 341069
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:341968:-1
position: 341968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341069-341968:-1:exon

YNL156C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSG2
locus tag: YNL156C
product: Nsg2p
transcript id: NM_001182994.3
SIO_010081: YNL156C
subclass of: SO_0000673
so part of: YNL156C
location: complement(<341069..>341968)
location: region:341069-341968:-1
so has part: feature:341069-341968:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341069-341968:-1:exon

YNL156C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSG2
locus tag: YNL156C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:16270032]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16270032]
note: Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication
codon start: 1
product: Nsg2p
translation: MANRGEPDPKKSTESICSLTKPQLYSLYDDDVVRSEDNEIYEELKRSVSIDSTKYSRDQTIDSTFYLAHKVGGSLPRNTVSSNNLERILSASSIHENFPSRTRQTRQNILHYLQAVLILSLSGFAYHELSRNLHDNHLLHPDFASRPLLLGVKLCNWLSNGVLPNWLGYGVEGLLFGSVVPILDNIFQTEVVKSSVHHDSLTSVIRSINAMLGVTFGIRKIQWNSSLQAAGAWGLLNIILWLFFDGSISMLMSCICIGVGCCISCYKDIIDGSQFLYFMDFYFLGSLMFGKLGRYLYSH
SIO_010081: YNL156C
subclass of: SO_0000673
so part of: YNL156C
location: complement(341069..341968)
location: region:341069-341968:-1
so has part: feature:341069-341968:-1:exon

NP_014243.3
type: Protein
SIO_000068: ncbiprotein

S000005100
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341069-341968:-1:exon

YNL155W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUZ1
locus tag: YNL155W
so part of: sequence
location: <342516..>343340
location: region:342516-343340:1
so has part: feature:342516-343340:1:exon
subclass of: SO_0000010

855567
type: Gene
SIO_000068: ncbigene

position:342516:1
position: 342516
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343340:1
position: 343340
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342516-343340:1:exon

YNL155W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUZ1
locus tag: YNL155W
product: Cuz1p
transcript id: NM_001182993.1
SIO_010081: YNL155W
subclass of: SO_0000673
so part of: YNL155W
location: <342516..>343340
location: region:342516-343340:1
so has part: feature:342516-343340:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342516-343340:1:exon

YNL155W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUZ1
locus tag: YNL155W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:24121501|PMID:24297164]
experiment: EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]
experiment: EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]
experiment: EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]
experiment: EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]
note: Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress
codon start: 1
product: Cuz1p
translation: MSAAIEKETGMLDVGKHCAYCRQLDFLPFHCSFCNEDFCSNHRLKEDHHCRWLLEHEEVHKTEKSPSKSRDGSSSNDEAYFKSLLPERASVRIQRVSETREPLRGSNTAKVSSTLNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIAKGDPKIPMQNRIYIWCYLVDGDETDIAKEDTRMPLYINKMWPVGRAMDYLSIQLNVKSSTLTNSSSNDKFQLCKLKEGKQVSFYNIGASLRVTNEIKDLDTLYLVHNNADEKSN
SIO_010081: YNL155W
subclass of: SO_0000673
so part of: YNL155W
location: 342516..343340
location: region:342516-343340:1
so has part: feature:342516-343340:1:exon

NP_014244.1
type: Protein
SIO_000068: ncbiprotein

S000005099
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342516-343340:1:exon

YNL154C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YCK2
locus tag: YNL154C
so part of: sequence
location: complement(<343636..>345276)
location: region:343636-345276:-1
so has part: feature:343636-345276:-1:exon
subclass of: SO_0000010

855568
type: Gene
SIO_000068: ncbigene

position:343636:-1
position: 343636
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345276:-1
position: 345276
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:343636-345276:-1:exon

YNL154C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YCK2
locus tag: YNL154C
product: serine/threonine protein kinase YCK2
transcript id: NM_001182992.1
SIO_010081: YNL154C
subclass of: SO_0000673
so part of: YNL154C
location: complement(<343636..>345276)
location: region:343636-345276:-1
so has part: feature:343636-345276:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:343636-345276:-1:exon

YNL154C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YCK2
locus tag: YNL154C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8474447]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:1627830|PMID:8034689|PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10198058]
experiment: EXISTENCE:direct assay:GO:0005937 mating projection [PMID:10198058]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000902 cell morphogenesis [PMID:8474447]
experiment: EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:27630263]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10198058]
experiment: EXISTENCE:mutant phenotype:GO:0009749 response to glucose [PMID:14755054]
note: Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase YCK2
translation: MSQVQSPLTATNSGLAVNNNTMNSQMPNRSNVRLVNGTLPPSLHVSSNLNHNTGNSSASYSGSQSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGLPVAIKFEPRKTEAPQLKDEYRTYKILAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEAMGHVFFYFLRGQLPWQGLKAPNNKQKYEKIGEKKRLTNVYDLAQGLPIQFGRYLEIVRNLSFEETPDYEGYRMLLLSVLDDLGETADGQYDWMKLNGGRGWDLSINKKPNLHGYGHPNPPNEKSKRHRSKNHQYSSPDHHHHYNQQQQQQQAQAQAQAQAQAKVQQQQLQQAQAQQQANRYQLQPDDSHYDEEREASKLDPTSYEAYQQQTQQKYAQQQQKQMQQKSKQFANTGANGQTNKYPYNAQPTANDEQNAKNAAQDRNSNKSSKGFFSKLGCC
SIO_010081: YNL154C
subclass of: SO_0000673
so part of: YNL154C
location: complement(343636..345276)
location: region:343636-345276:-1
so has part: feature:343636-345276:-1:exon

NP_014245.1
type: Protein
SIO_000068: ncbiprotein

S000005098
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:343636-345276:-1:exon

YNL153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PFD4
gene: GIM3
locus tag: YNL153C
gene synonym: PFD4
so part of: sequence
location: complement(<345669..>346058)
location: region:345669-346058:-1
so has part: feature:345669-346058:-1:exon
subclass of: SO_0000010

855569
type: Gene
SIO_000068: ncbigene

position:345669:-1
position: 345669
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346058:-1
position: 346058
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:345669-346058:-1:exon

YNL153C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PFD4
gene: GIM3
locus tag: YNL153C
gene synonym: PFD4
product: tubulin-binding prefolding complex subunit GIM3
transcript id: NM_001182991.1
SIO_010081: YNL153C
subclass of: SO_0000673
so part of: YNL153C
location: complement(<345669..>346058)
location: region:345669-346058:-1
so has part: feature:345669-346058:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:345669-346058:-1:exon

YNL153C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PFD4
gene: GIM3
locus tag: YNL153C
gene synonym: PFD4
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]
experiment: EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:27448207]
experiment: EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]
note: Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
codon start: 1
product: tubulin-binding prefolding complex subunit GIM3
translation: MELLPQGQRNNTQVTFEDQQKINEFSKLIMRKDAIAQELSLQREEKEYLDDVSLEIELIDEDEPVQYKVGDLFIFMKQSKVTAQLEKDAERLDNKIETLEDKQRDIDSRLDALKAILYAKFGDNINLER
SIO_010081: YNL153C
subclass of: SO_0000673
so part of: YNL153C
location: complement(345669..346058)
location: region:345669-346058:-1
so has part: feature:345669-346058:-1:exon

NP_014246.1
type: Protein
SIO_000068: ncbiprotein

S000005097
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:345669-346058:-1:exon

YNL152W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INN1
locus tag: YNL152W
so part of: sequence
location: <346313..>347542
location: region:346313-347542:1
so has part: feature:346313-347542:1:exon
subclass of: SO_0000010

855570
type: Gene
SIO_000068: ncbigene

position:346313:1
position: 346313
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:347542:1
position: 347542
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346313-347542:1:exon

YNL152W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INN1
locus tag: YNL152W
product: Inn1p
transcript id: NM_001182990.1
SIO_010081: YNL152W
subclass of: SO_0000673
so part of: YNL152W
location: <346313..>347542
location: region:346313-347542:1
so has part: feature:346313-347542:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346313-347542:1:exon

YNL152W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INN1
locus tag: YNL152W
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:18344988]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:22956544]
experiment: EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]
experiment: EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:18344988|PMID:22956544]
experiment: EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]
experiment: EXISTENCE:mutant phenotype:GO:1990344 secondary cell septum biogenesis [PMID:19528296]
experiment: EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]
note: Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
codon start: 1
product: Inn1p
translation: MSEEVWNGNQGILSVYVSKARDLPNLNKLDKQNVMLRLRIAHMTRASNTLHRAGQNPVFHYLEKFDITPEIKPLMYVEVYCDRRKKSPLPIGRCEIDLLNAIRADPKEGYCTWYELKRSGDEFAGTIFIELTFTPKVPRLNRDDLNKEMDRLDSSMAMRPIPPLPTESEYDYVHGSTMRQITPQCVSTSHEDKDEGQPYRNGNVFSMSSKSDTAVLANSNDPIILPPTFSASMGTTSTLETNDTAISNTSNTKFHFANLRKLKEKINIFKNPDSSTNNCQNESNKVDIEALQKAIGVTSLSYDEDDDDDDENDAFYSSSHRVSHNYNQPPLPPIPTRDDMSNYSSSRNTPLVRRDRPSRLDSSSPNSHPHPSGLNSPKLPPLPTTSNSNFNSRKNSMSPTRKRPPPRLS
SIO_010081: YNL152W
subclass of: SO_0000673
so part of: YNL152W
location: 346313..347542
location: region:346313-347542:1
so has part: feature:346313-347542:1:exon

NP_014247.1
type: Protein
SIO_000068: ncbiprotein

S000005096
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346313-347542:1:exon

YNL151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACP2
alternative label: RPC8
gene: RPC31
locus tag: YNL151C
gene synonym: ACP2; RPC8
so part of: sequence
location: complement(<347766..>348521)
location: region:347766-348521:-1
so has part: feature:347766-348521:-1:exon
subclass of: SO_0000010

855571
type: Gene
SIO_000068: ncbigene

position:347766:-1
position: 347766
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:348521:-1
position: 348521
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347766-348521:-1:exon

YNL151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACP2
alternative label: RPC8
gene: RPC31
locus tag: YNL151C
gene synonym: ACP2; RPC8
product: DNA-directed RNA polymerase III subunit C31
transcript id: NM_001182989.3
SIO_010081: YNL151C
subclass of: SO_0000673
so part of: YNL151C
location: complement(<347766..>348521)
location: region:347766-348521:-1
so has part: feature:347766-348521:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:347766-348521:-1:exon

YNL151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACP2
alternative label: RPC8
gene: RPC31
locus tag: YNL151C
gene synonym: ACP2; RPC8
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:mutant phenotype:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:7835345]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:2201900]
note: RNA polymerase III subunit C31
codon start: 1
product: DNA-directed RNA polymerase III subunit C31
translation: MSSYRGGSRGGGSNYMSNLPFGLGYGDVGKNHITEFPSIPLPINGPITNKERSLAVKYINFGKTVKDGPFYTGSMSLIIDQQENSKSGKRKPNIILDEDDTNDGIERYSDKYLKKRKIGISIDDHPYNLNLFPNELYNVMGINKKKLLAISKFNNADDVFTGTGLQDENIGLSMLAKLKELAEDVDDASTGDGAAKGSKTGEGEDDDLADDDFEEDEDEEDDDDYNAEKYFNNGDDDDYGDEEDPNEEAAF
SIO_010081: YNL151C
subclass of: SO_0000673
so part of: YNL151C
location: complement(347766..348521)
location: region:347766-348521:-1
so has part: feature:347766-348521:-1:exon

NP_014248.3
type: Protein
SIO_000068: ncbiprotein

S000005095
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:347766-348521:-1:exon

YNL149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PGA2
locus tag: YNL149C
so part of: sequence
location: complement(<349367..>349756)
location: region:349367-349756:-1
so has part: feature:349367-349756:-1:exon
subclass of: SO_0000010

855573
type: Gene
SIO_000068: ncbigene

position:349367:-1
position: 349367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349756:-1
position: 349756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349367-349756:-1:exon

YNL149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PGA2
locus tag: YNL149C
product: Pga2p
transcript id: NM_001182987.1
SIO_010081: YNL149C
subclass of: SO_0000673
so part of: YNL149C
location: complement(<349367..>349756)
location: region:349367-349756:-1
so has part: feature:349367-349756:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349367-349756:-1:exon

YNL149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PGA2
locus tag: YNL149C
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:14690591|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:16943325]
note: Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
codon start: 1
product: Pga2p
translation: MSEVAETWVDTWMAKLVNYDYKHFIRLVIIVGGYLLLRNIASRELAKKQLAAQVEKDKRDKEEKRSKDLIDKPDDAATAETTSFGWGKKTRRRVKRQQELFENALEEAKRRNQGLDPDSDADIEELLEE
SIO_010081: YNL149C
subclass of: SO_0000673
so part of: YNL149C
location: complement(349367..349756)
location: region:349367-349756:-1
so has part: feature:349367-349756:-1:exon

NP_014250.1
type: Protein
SIO_000068: ncbiprotein

S000005093
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349367-349756:-1:exon

YNL148C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALF1
locus tag: YNL148C
so part of: sequence
location: complement(<349907..>350671)
location: region:349907-350671:-1
so has part: feature:349907-350671:-1:exon
subclass of: SO_0000010

855574
type: Gene
SIO_000068: ncbigene

position:349907:-1
position: 349907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:350671:-1
position: 350671
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349907-350671:-1:exon

YNL148C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALF1
locus tag: YNL148C
product: Alf1p
transcript id: NM_001182986.1
SIO_010081: YNL148C
subclass of: SO_0000673
so part of: YNL148C
location: complement(<349907..>350671)
location: region:349907-350671:-1
so has part: feature:349907-350671:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349907-350671:-1:exon

YNL148C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALF1
locus tag: YNL148C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:9885248]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9885248]
experiment: EXISTENCE:mutant phenotype:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]
experiment: EXISTENCE:physical interaction:GO:0043014 alpha-tubulin binding [PMID:9885248]
note: Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
codon start: 1
product: Alf1p
translation: MVRVVIESELVRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIVVKRQYDNKEIYSTKKGGAYSNEDEDANFLKGEEELIVVVTDSNAQSISNQLATQAEGIPSMEVISEEDYLRRDQSVLRWKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTAAIGRHCRVTVDGSAPREAILRYVGPLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAPGHGSFVRPRAVEILSKDEESAEVEDVHDDVESDDEI
SIO_010081: YNL148C
subclass of: SO_0000673
so part of: YNL148C
location: complement(349907..350671)
location: region:349907-350671:-1
so has part: feature:349907-350671:-1:exon

NP_014251.1
type: Protein
SIO_000068: ncbiprotein

S000005092
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349907-350671:-1:exon

YNL147W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LSM7
locus tag: YNL147W
so part of: sequence
location: <350940..>351383
location: region:350940-351383:1
so has part: feature:350940-351383:1:exon
subclass of: SO_0000010

855575
type: Gene
SIO_000068: ncbigene

position:350940:1
position: 350940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351383:1
position: 351383
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:350940-351383:1:exon

YNL147W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LSM7
locus tag: YNL147W
product: Sm-like protein LSM7
transcript id: NM_001182985.1
SIO_010081: YNL147W
subclass of: SO_0000673
so part of: YNL147W
location: join(<350940..350957,351054..>351383)
location: region:350940-351383:1
so has part: feature:350940-350957:1:exon
so has part: feature:351054-351383:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:350940-350957:1:exon

position:350957:1
position: 350957
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:351054-351383:1:exon

position:351054:1
position: 351054
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL147W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LSM7
locus tag: YNL147W
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10747033|PMID:10369684|PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370|PMID:18029398]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18029398|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419]
experiment: EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:11333229|PMID:10428970]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10747033]
experiment: EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]
experiment: EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]
note: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
codon start: 1
product: Sm-like protein LSM7
translation: MHQQHSKSENKPQQQRKKFEGPKREAILDLAKYKDSKIRVKLMGGKLVIGVLKGYDQLMNLVLDDTVEYMSNPDDENNTELISKNARKLGLTVIRGTILVSLSSAEGSDVLYMQK
SIO_010081: YNL147W
subclass of: SO_0000673
so part of: YNL147W
location: join(350940..350957,351054..351383)
location: region:350940-351383:1
so has part: feature:350940-350957:1:exon
so has part: feature:351054-351383:1:exon

NP_014252.2
type: Protein
SIO_000068: ncbiprotein

S000005091
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:350940-350957:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:351054-351383:1:exon

YNL146C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL146C-A
so part of: sequence
location: complement(<351386..>351580)
location: region:351386-351580:-1
so has part: feature:351386-351580:-1:exon
subclass of: SO_0000010

1466510
type: Gene
SIO_000068: ncbigene

position:351386:-1
position: 351386
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351580:-1
position: 351580
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:351386-351580:-1:exon

YNL146C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL146C-A
product: uncharacterized protein
transcript id: NM_001184663.1
SIO_010081: YNL146C-A
subclass of: SO_0000673
so part of: YNL146C-A
location: complement(<351386..>351580)
location: region:351386-351580:-1
so has part: feature:351386-351580:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:351386-351580:-1:exon

YNL146C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL146C-A
codon start: 1
product: uncharacterized protein
translation: MISVCFVFPHSLALDFKSRCKKNRTKLCSAYYVSQVLRICKEMPYRDLILFSTVRKGVYMRLYY
SIO_010081: YNL146C-A
subclass of: SO_0000673
so part of: YNL146C-A
location: complement(351386..351580)
location: region:351386-351580:-1
so has part: feature:351386-351580:-1:exon

NP_878152.1
type: Protein
SIO_000068: ncbiprotein

S000028851
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:351386-351580:-1:exon

YNL146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL146W
so part of: sequence
location: <351715..>352017
location: region:351715-352017:1
so has part: feature:351715-352017:1:exon
subclass of: SO_0000010

855576
type: Gene
SIO_000068: ncbigene

position:351715:1
position: 351715
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352017:1
position: 352017
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:351715-352017:1:exon

YNL146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL146W
product: uncharacterized protein
transcript id: NM_001182984.3
SIO_010081: YNL146W
subclass of: SO_0000673
so part of: YNL146W
location: <351715..>352017
location: region:351715-352017:1
so has part: feature:351715-352017:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:351715-352017:1:exon

YNL146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL146W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSNTKHTTSHHMELKRIIILTLLFILIMLIFRNSVSFKMTFQELLPRFYKKNSNSVSNNNRPSSIFSENLVDFDDVNMVDKTRLFIFLFFSFIITIPFMV
SIO_010081: YNL146W
subclass of: SO_0000673
so part of: YNL146W
location: 351715..352017
location: region:351715-352017:1
so has part: feature:351715-352017:1:exon

NP_014253.3
type: Protein
SIO_000068: ncbiprotein

S000005090
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:351715-352017:1:exon

YNL145W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MFA2
locus tag: YNL145W
so part of: sequence
location: <352414..>352530
location: region:352414-352530:1
so has part: feature:352414-352530:1:exon
subclass of: SO_0000010

855577
type: Gene
SIO_000068: ncbigene

position:352414:1
position: 352414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352530:1
position: 352530
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352414-352530:1:exon

YNL145W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MFA2
locus tag: YNL145W
product: mating pheromone a
transcript id: NM_001182983.1
SIO_010081: YNL145W
subclass of: SO_0000673
so part of: YNL145W
location: <352414..>352530
location: region:352414-352530:1
so has part: feature:352414-352530:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:352414-352530:1:exon

YNL145W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MFA2
locus tag: YNL145W
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:2046670]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006113 fermentation [PMID:29425293]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3285180]
experiment: EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3285180]
note: Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
codon start: 1
product: mating pheromone a
translation: MQPITTASTQATQKDKSSEKKDNYIIKGLFWDPACVIA
SIO_010081: YNL145W
subclass of: SO_0000673
so part of: YNL145W
location: 352414..352530
location: region:352414-352530:1
so has part: feature:352414-352530:1:exon

NP_014254.1
type: Protein
SIO_000068: ncbiprotein

S000005089
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352414-352530:1:exon

YNL144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL144C
so part of: sequence
location: complement(<352820..>355042)
location: region:352820-355042:-1
so has part: feature:352820-355042:-1:exon
subclass of: SO_0000010

855578
type: Gene
SIO_000068: ncbigene

position:352820:-1
position: 352820
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:355042:-1
position: 355042
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352820-355042:-1:exon

YNL144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL144C
product: uncharacterized protein
transcript id: NM_001182982.1
SIO_010081: YNL144C
subclass of: SO_0000673
so part of: YNL144C
location: complement(<352820..>355042)
location: region:352820-355042:-1
so has part: feature:352820-355042:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:352820-355042:-1:exon

YNL144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL144C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; YNL144C has a paralog, YHR131C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSSSIFEMTIDHDGMDSTGLKLSQTASSISMGDEFLCSSTTSNSILDSPLPKVTFNHIDSITDINTNIMNEIVEPQSGVDVDVADKNVLYCIDPYPVEPPCYDFANPSKVIRYPIYEHCRPCLTSVKPPSYTPSVEHYTVVSMKMEKLSPFENASSRLWNNFILQINSTQINFYSIDDSLTRHIKNYRGGDMFDHSHHSKTASDRHHSARSLLNAFTTKSTYQFDKYDKERICGEIARDEHKFLSDERLFKSYSLQCAKVGLPIDYSSRDFVLRMRCEGQQFLVQFSHVDELIYWAMYLNMGISLSLDLELREMPTYRSVPRRRHPRARRFKQHNKNKNKNKSRQNSDRNDSRSHSLLLRRSHTSSVVTKVATGNERPTNKSRSRSLSLLPPSVSDASHDSNGPNDSGSLAGESSQTDFCGLFTSKLRNFFKTDSSSRKNSNMDIGQKMRSKELNSVQEEIDDNGSTTNTNTSVLSSTFSPTAHSVLTAQTSIHENFRSRSNSNPIDPLRCDRSVLKINNFEPVYEGTGRSTISNSAERTNREEKLNRGNEDVNGDEDDDEDEDDANYEEDDEDGYVEDDDINRLVYLDERESRYENADVEYGTIFSTKSFSVTGCLNHDFPKKLSLKCGNKNQSSNDSKWAPATQLVSRKRYIKDSLRCIKPLTEDHPWVGKIIFKPALPPAFETNNPPIRVYSGEDSTDLMHVKNHYLKPYIVGSCGFLKTGSKLFHFYDRTNDLTNL
SIO_010081: YNL144C
subclass of: SO_0000673
so part of: YNL144C
location: complement(352820..355042)
location: region:352820-355042:-1
so has part: feature:352820-355042:-1:exon

NP_014255.1
type: Protein
SIO_000068: ncbiprotein

S000005088
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352820-355042:-1:exon

YNL143C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL143C
so part of: sequence
location: complement(<356794..>357186)
location: region:356794-357186:-1
so has part: feature:356794-357186:-1:exon
subclass of: SO_0000010

855579
type: Gene
SIO_000068: ncbigene

position:356794:-1
position: 356794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:357186:-1
position: 357186
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:356794-357186:-1:exon

YNL143C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL143C
product: uncharacterized protein
transcript id: NM_001270759.1
SIO_010081: YNL143C
subclass of: SO_0000673
so part of: YNL143C
location: complement(<356794..>357186)
location: region:356794-357186:-1
so has part: feature:356794-357186:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:356794-357186:-1:exon

YNL143C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL143C
note: hypothetical protein; expressed at both mRNA and protein levels
codon start: 1
product: uncharacterized protein
translation: MREQLKLFTREIVDFTFLILSGFDYYQTLLISSNSSKKRPKDSSLLSEKKKKKKKKKKDVLSYLSYLKDLPFVPFLFWQPGYSQREKNPRQHSLFIMTITKPGMISMADMNYVVSKNRSLNRPAERGGNR
SIO_010081: YNL143C
subclass of: SO_0000673
so part of: YNL143C
location: complement(356794..357186)
location: region:356794-357186:-1
so has part: feature:356794-357186:-1:exon

NP_001257688.1
type: Protein
SIO_000068: ncbiprotein

S000005087
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:356794-357186:-1:exon

YNL142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MEP2
locus tag: YNL142W
so part of: sequence
location: <357453..>358952
location: region:357453-358952:1
so has part: feature:357453-358952:1:exon
subclass of: SO_0000010

855580
type: Gene
SIO_000068: ncbigene

position:357453:1
position: 357453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:358952:1
position: 358952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357453-358952:1:exon

YNL142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MEP2
locus tag: YNL142W
product: ammonium permease MEP2
transcript id: NM_001182980.1
SIO_010081: YNL142W
subclass of: SO_0000673
so part of: YNL142W
location: <357453..>358952
location: region:357453-358952:1
so has part: feature:357453-358952:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:357453-358952:1:exon

YNL142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MEP2
locus tag: YNL142W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11069679|PMID:24124599]
experiment: EXISTENCE:direct assay:GO:0008519 ammonium transmembrane transporter activity [PMID:9234685]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9482721]
experiment: EXISTENCE:mutant phenotype:GO:0008519 ammonium transmembrane transporter activity [PMID:9234685]
experiment: EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]
experiment: EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]
experiment: EXISTENCE:mutant phenotype:GO:1900430 positive regulation of filamentous growth of a population of unicellular organisms [PMID:32069286]
note: Ammonium permease involved in regulation of pseudohyphal growth; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes human Rh factors; expression is under nitrogen catabolite repression regulation; activity is controlled by phospho-silencing; phosphorylation of Mep2 mediated by Npr1; dephosphorylation involves Psr1p and Psr2p; Twin-His motif ensures transport specificity
codon start: 1
product: ammonium permease MEP2
translation: MSYNFTGTPTGEGTGGNSLTTDLNTQFDLANMGWIGVASAGVWIMVPGIGLLYSGLSRKKHALSLLWASMMASAVCIFQWFFWGYSLAFSHNTRGNGFIGTLEFFGFRNVLGAPSSVSSLPDILFAVYQGMFAAVTGALMLGGACERARLFPMMVFLFLWMTIVYCPIACWVWNAEGWLVKLGSLDYAGGLCVHLTSGHGGLVYALILGKRNDPVTRKGMPKYKPHSVTSVVLGTVFLWFGWMFFNGGSAGNATIRAWYSIMSTNLAAACGGLTWMVIDYFRCGRKWTTVGLCSGIIAGLVGITPAAGFVPIWSAVVIGVVTGAGCNLAVDLKSLLRIDDGLDCYSIHGVGGCIGSVLTGIFAADYVNATAGSYISPIDGGWINHHYKQVGYQLAGICAALAWTVTVTSILLLTMNAIPFLKLRLSADEEELGTDAAQIGEFTYEESTAYIPEPIRSKTSAQMPPPHENIDDKIVGNTDAEKNSTPSDASSTKNTDHIV
SIO_010081: YNL142W
subclass of: SO_0000673
so part of: YNL142W
location: 357453..358952
location: region:357453-358952:1
so has part: feature:357453-358952:1:exon

NP_014257.1
type: Protein
SIO_000068: ncbiprotein

S000005086
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:357453-358952:1:exon

YNL141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAH1
locus tag: YNL141W
so part of: sequence
location: <359596..>360639
location: region:359596-360639:1
so has part: feature:359596-360639:1:exon
subclass of: SO_0000010

855581
type: Gene
SIO_000068: ncbigene

position:359596:1
position: 359596
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360639:1
position: 360639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359596-360639:1:exon

YNL141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAH1
locus tag: YNL141W
product: adenine deaminase
transcript id: NM_001182979.1
SIO_010081: YNL141W
subclass of: SO_0000673
so part of: YNL141W
location: <359596..>360639
location: region:359596-360639:1
so has part: feature:359596-360639:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359596-360639:1:exon

YNL141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAH1
locus tag: YNL141W
EC number: 3.5.4.2
experiment: EXISTENCE:direct assay:GO:0000034 adenine deaminase activity [PMID:1577682]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006146 adenine catabolic process [PMID:1577682]
experiment: EXISTENCE:direct assay:GO:0043101 purine-containing compound salvage [PMID:1577682]
experiment: EXISTENCE:direct assay:GO:0043103 hypoxanthine salvage [PMID:1577682]
experiment: EXISTENCE:mutant phenotype:GO:0000034 adenine deaminase activity [PMID:1577682]
experiment: EXISTENCE:mutant phenotype:GO:0006146 adenine catabolic process [PMID:1577682]
experiment: EXISTENCE:mutant phenotype:GO:0043101 purine-containing compound salvage [PMID:1577682]
experiment: EXISTENCE:mutant phenotype:GO:0043103 hypoxanthine salvage [PMID:1577682]
note: Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
codon start: 1
product: adenine deaminase
translation: MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFPKSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVFYDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEATPFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDALDLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDRDVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGLLSRVDEVVTKYSH
SIO_010081: YNL141W
subclass of: SO_0000673
so part of: YNL141W
location: 359596..360639
location: region:359596-360639:1
so has part: feature:359596-360639:1:exon

NP_014258.1
type: Protein
SIO_000068: ncbiprotein

S000005085
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359596-360639:1:exon

YNL140C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL140C
so part of: sequence
location: complement(<360917..>361486)
location: region:360917-361486:-1
so has part: feature:360917-361486:-1:exon
subclass of: SO_0000010

855582
type: Gene
SIO_000068: ncbigene

position:360917:-1
position: 360917
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361486:-1
position: 361486
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360917-361486:-1:exon

YNL140C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL140C
product: uncharacterized protein
transcript id: NM_001270760.1
SIO_010081: YNL140C
subclass of: SO_0000673
so part of: YNL140C
location: complement(<360917..>361486)
location: region:360917-361486:-1
so has part: feature:360917-361486:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360917-361486:-1:exon

YNL140C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL140C
note: hypothetical protein; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
codon start: 1
product: uncharacterized protein
translation: MLEAKMVMVVPTIEDQAMIVLHPKILSQSVVMHIKGQNYQLDLVKVKHIMIEVGHLDPQVRTGAMVLIKGITAYVKSIRKTVHNVHNYGFLKSHFKRAKTAAKPTLTKLHLTSATRLQKMKKSRIKDSRRMKQLETNFKRKIIEIHEIAVLPIEPMKIKGTTEIERAILRRFRKVPRVGITSVGTRGNY
SIO_010081: YNL140C
subclass of: SO_0000673
so part of: YNL140C
location: complement(360917..361486)
location: region:360917-361486:-1
so has part: feature:360917-361486:-1:exon

NP_001257689.1
type: Protein
SIO_000068: ncbiprotein

S000005084
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360917-361486:-1:exon

YNL139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LDB5
alternative label: RLR1
alternative label: ZRG13
gene: THO2
locus tag: YNL139C
gene synonym: LDB5; RLR1; ZRG13
so part of: sequence
location: complement(<360924..>365717)
location: region:360924-365717:-1
so has part: feature:360924-365717:-1:exon
subclass of: SO_0000010

855583
type: Gene
SIO_000068: ncbigene

position:360924:-1
position: 360924
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:365717:-1
position: 365717
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360924-365717:-1:exon

YNL139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LDB5
alternative label: RLR1
alternative label: ZRG13
gene: THO2
locus tag: YNL139C
gene synonym: LDB5; RLR1; ZRG13
product: Tho2p
transcript id: NM_001182977.3
SIO_010081: YNL139C
subclass of: SO_0000673
so part of: YNL139C
location: complement(<360924..>365717)
location: region:360924-365717:-1
so has part: feature:360924-365717:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360924-365717:-1:exon

YNL139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LDB5
alternative label: RLR1
alternative label: ZRG13
gene: THO2
locus tag: YNL139C
gene synonym: LDB5; RLR1; ZRG13
experiment: EXISTENCE:direct assay:GO:0000445 THO complex part of transcription export complex [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]
experiment: EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11139493|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:12093753|PMID:17960421]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:26663077]
experiment: EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:26663077]
note: Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
codon start: 1
product: Tho2p
translation: MAEQTLLSKLNALSQKVIPPASPSQASILTEEVIRNWPERSKTLCSDFTALESNDEKEDWLRTLFIELFDFINKNDENSPLKLSDVASFTNELVNHERQVSQASIVGKMFIAVSSTVPNINDLTTISLCKLIPSLHEELFKFSWISSKLLNKEQTTLLRHLLKKSKYELKKYNLLVENSVGYGQLVALLILAYYDPDNFSKVSAYLKEIYHIMGKYSLDSIRTLDVILNVSSQFITEGYKFFIALLRKSDSWPSSHVANNSNYSSLNEGGNMIAANIISFNLSQYNEEVDKENYERYMDMCCILLKNGFVNFYSIWDNVKPEMEFLQEYIQNLETELEEESTKGVENPLAMAAALSTENETDEDNALVVNDDVNMKDKISEETNADIESKGKQKTQQDILLFGKIKLLERLLIHGCVIPVIHVLKQYPKVLYVSESLSRYLGRVFEYLLNPLYTSMTSSGESKDMATALMITRIDNGILAHKPRLIHKYKTHEPFESLELNSSYVFYYSEWNSNLTPFASVNDLFENSHIYLSIIGPYLGRIPTLLSKISRIGVADIQKNHGSESLHVTIDKWIDYVRKFIFPATSLLQNNPIATSEVYELMKFFPFEKRYFIYNEMMTKLSQDILPLKVSFNKAEREAKSILKALSIDTIAKESRRFAKLISTNPLASLVPAVKQIENYDKVSELVVYTTKYFNDFAYDVLQFVLLLRLTYNRPAVQFDGVNQAMWVQRLSIFIAGLAKNCPNMDISNIITYILKTLHNGNIIAVSILKELIITVGGIRDLNEVNMKQLLMLNSGSPLKQYARHLIYDFRDDNSVISSRLTSFFTDQSAISEIILLLYTLNLKANTQNSHYKILSTRCDEMNTLLWSFIELIKHCLKGKAFEENVLPFVELNNRFHLSTPWTFHIWRDYLDNQLNSNENFSIDELIEGAEFSDVDLTKISKDLFTTFWRLSLYDIHFDKSLYDERKNALSGENTGHMSNRKKHLIQNQIKDILVTGISHQRAFKKTSEFISEKSNVWNKDCGEDQIKIFLQNCVVPRVLFSPSDALFSSFFIFMAFRTENLMSILNTCITSNILKTLLFCCTSSEAGNLGLFFTDVLKKLEKMRLNGDFNDQASRKLYEWHSVITEQVIDLLSEKNYMSIRNGIEFMKHVTSVFPVVKAHIQLVYTTLEENLINEEREDIKLPSSALIGHLKARLKDALELDEFCTLTEEEAEQKRIREMELEEIKNYETACQNEQKQVALRKQLELNKSQRLQNDPPKSVASGSAGLNSKDRYTYSRNEPVIPTKPSSSQWSYSKVTRHVDDINHYLATNHLQKAISLVENDDETRNLRKLSKQNMPIFDFRNSTLEIFERYFRTLIQNPQNPDFAEKIDSLKRYIKNISREPYPDTTSSYSEAAAPEYTKRSSRYSGNAGGKDGYGSSNYRGPSNDRSAPKNIKPISSYAHKRSELPTRPSKSKTYNDRSRALRPTGPDRGDGFDQRDNRLREEYKKNSSQRSQLRFPEKPFQEGKDSSKANPYQASSYKRDSPSENEEKPNKRFKKDETIRNKFQTQDYRNTRDSGAAHRANENQRYNGNRKSNTQALPQGPKGGNYVSRYQR
SIO_010081: YNL139C
subclass of: SO_0000673
so part of: YNL139C
location: complement(360924..365717)
location: region:360924-365717:-1
so has part: feature:360924-365717:-1:exon

NP_014260.3
type: Protein
SIO_000068: ncbiprotein

S000005083
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360924-365717:-1:exon

YNL138W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RCP10
gene: YSF3
locus tag: YNL138W-A
gene synonym: RCP10
so part of: sequence
location: <366033..>366412
location: region:366033-366412:1
so has part: feature:366033-366412:1:exon
subclass of: SO_0000010

1466511
type: Gene
SIO_000068: ncbigene

position:366033:1
position: 366033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:366412:1
position: 366412
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366033-366412:1:exon

YNL138W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RCP10
gene: YSF3
locus tag: YNL138W-A
gene synonym: RCP10
product: U2 snRNP complex subunit YSF3
transcript id: NM_001184519.1
SIO_010081: YNL138W-A
subclass of: SO_0000673
so part of: YNL138W-A
location: join(<366033..366035,366158..>366412)
location: region:366033-366412:1
so has part: feature:366033-366035:1:exon
so has part: feature:366158-366412:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366033-366035:1:exon

position:366035:1
position: 366035
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:366158-366412:1:exon

position:366158:1
position: 366158
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL138W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RCP10
gene: YSF3
locus tag: YNL138W-A
gene synonym: RCP10
experiment: EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500|PMID:15565172]
experiment: EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:16314500]
note: Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b
codon start: 1
product: U2 snRNP complex subunit YSF3
translation: MAEKQRQLKLQKIYKQKYIGLGDESTTREQWQRNVRNDTLNTLQGHSASLEYVSLSRGDLSIRDTRIHLLKSMSPGYKAYLREER
SIO_010081: YNL138W-A
subclass of: SO_0000673
so part of: YNL138W-A
location: join(366033..366035,366158..366412)
location: region:366033-366412:1
so has part: feature:366033-366035:1:exon
so has part: feature:366158-366412:1:exon

NP_878153.1
type: Protein
SIO_000068: ncbiprotein

S000028509
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366033-366035:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:366158-366412:1:exon

YNL138W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CAP
gene: SRV2
locus tag: YNL138W
gene synonym: CAP
so part of: sequence
location: <366741..>368321
location: region:366741-368321:1
so has part: feature:366741-368321:1:exon
subclass of: SO_0000010

855584
type: Gene
SIO_000068: ncbigene

position:366741:1
position: 366741
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:368321:1
position: 368321
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366741-368321:1:exon

YNL138W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CAP
gene: SRV2
locus tag: YNL138W
gene synonym: CAP
product: adenylate cyclase-binding protein
transcript id: NM_001182976.1
SIO_010081: YNL138W
subclass of: SO_0000673
so part of: YNL138W
location: <366741..>368321
location: region:366741-368321:1
so has part: feature:366741-368321:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366741-368321:1:exon

YNL138W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CAP
gene: SRV2
locus tag: YNL138W
gene synonym: CAP
experiment: EXISTENCE:direct assay:GO:0003779 actin binding [PMID:19201756]
experiment: EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:19201756]
experiment: EXISTENCE:direct assay:GO:0008179 adenylate cyclase binding [PMID:2184942]
experiment: EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:26458246]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8552082]
experiment: EXISTENCE:direct assay:GO:0030836 positive regulation of actin filament depolymerization [PMID:26458246]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:23135996]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:19201756]
experiment: EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:9774417]
experiment: EXISTENCE:mutant phenotype:GO:0030833 regulation of actin filament polymerization [PMID:30639852]
experiment: EXISTENCE:mutant phenotype:GO:0090141 positive regulation of mitochondrial fission [PMID:30639852]
note: CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog
codon start: 1
product: adenylate cyclase-binding protein
translation: MPDSKYTMQGYNLVKLLKRLEEATARLEDVTIYQEGYIQNKLEASKNNKPSDSGADANTTNEPSAENAPEVEQDPKCITAFQSYIGENIDPLVELSGKIDTVVLDALQLLKGGFQSQLTFLRAAVRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQSKYFAYLSALSEGAPLFSWVAVDTPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYIKEYHTTGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPAPPPPPPAPPASVFEISNDTPATSSDANKGGIGAVFAELNQGENITKGLKKVDKSQQTHKNPELRQSSTVSSTGSKSGPPPRPKKPSTLKTKRPPRKELVGNKWFIENYENETESLVIDANKDESIFIGKCSQVLVQIKGKVNAISLSETESCSVVLDSSISGMDVIKSNKFGIQVNHSLPQISIDKSDGGNIYLSKESLNTEIYTSCSTAINVNLPIGEDDDYVEFPIPEQMKHSFADGKFKSAVFEHAG
SIO_010081: YNL138W
subclass of: SO_0000673
so part of: YNL138W
location: 366741..368321
location: region:366741-368321:1
so has part: feature:366741-368321:1:exon

NP_014261.1
type: Protein
SIO_000068: ncbiprotein

S000005082
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366741-368321:1:exon

YNL137C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MNA6
alternative label: uS4m
gene: NAM9
locus tag: YNL137C
gene synonym: MNA6; uS4m
so part of: sequence
location: complement(<368595..>370055)
location: region:368595-370055:-1
so has part: feature:368595-370055:-1:exon
subclass of: SO_0000010

855585
type: Gene
SIO_000068: ncbigene

position:368595:-1
position: 368595
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370055:-1
position: 370055
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368595-370055:-1:exon

YNL137C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MNA6
alternative label: uS4m
gene: NAM9
locus tag: YNL137C
gene synonym: MNA6; uS4m
product: mitochondrial 37S ribosomal protein NAM9
transcript id: NM_001182975.3
SIO_010081: YNL137C
subclass of: SO_0000673
so part of: YNL137C
location: complement(<368595..>370055)
location: region:368595-370055:-1
so has part: feature:368595-370055:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368595-370055:-1:exon

YNL137C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MNA6
alternative label: uS4m
gene: NAM9
locus tag: YNL137C
gene synonym: MNA6; uS4m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal component of the small subunit
codon start: 1
product: mitochondrial 37S ribosomal protein NAM9
translation: MPRKANLLKSLARGRVRTSFNKYNLFNLYKKGGVDLKSKSLYQQKWTAKQETRAYHGEHLTEKRWQTVFKPKLDSVAQLDASLRGGEIKETPFLLQTFAVLEKRLDFALFRAMFASSVRQARQFILHGNVRVNGVKIKHPSYTLKPGDMFSVKPDKVLEALGAKKPSFQEALKIDKTQIVLWNKYVKEAKTEPKEVWEKKLENFEKMSDSNPKKLQFQEFLRQYNKNLESQQYNALKGCTQEGILRKLLNVEKEIGKSNNEPLSIDELKQGLPEIQDSQLLESLNNAYQEFFKSGEIRREIISKCQPDELISLATEMMNPNETTKKELSDGAKSALRSGKRIIAESVKLWTKNITDHFKTRMSDISDGSLTFDPKWAKNLKYHDPIKLSELEGDEPKARKLINLPWQKNYVYGRQDPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVISPFDVPVHERAYMYYLRNGK
SIO_010081: YNL137C
subclass of: SO_0000673
so part of: YNL137C
location: complement(368595..370055)
location: region:368595-370055:-1
so has part: feature:368595-370055:-1:exon

NP_014262.3
type: Protein
SIO_000068: ncbiprotein

S000005081
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368595-370055:-1:exon

YNL136W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EAF7
locus tag: YNL136W
so part of: sequence
location: <370368..>371645
location: region:370368-371645:1
so has part: feature:370368-371645:1:exon
subclass of: SO_0000010

855586
type: Gene
SIO_000068: ncbigene

position:370368:1
position: 370368
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371645:1
position: 371645
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370368-371645:1:exon

YNL136W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EAF7
locus tag: YNL136W
product: Eaf7p
transcript id: NM_001182974.1
SIO_010081: YNL136W
subclass of: SO_0000673
so part of: YNL136W
location: <370368..>371645
location: region:370368-371645:1
so has part: feature:370368-371645:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370368-371645:1:exon

YNL136W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EAF7
locus tag: YNL136W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15353583]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]
experiment: EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]
note: Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A
codon start: 1
product: Eaf7p
translation: MVVHWTIVDEIRLLRWASEFKPAGIHKHFHMFCIVERMNSPDKYPVTLLQKETMKLGKVFTAKDIWDKLSQSYNLEKIDEMENTYSLEATTESSRNGNGNGDDAEIHEETLLELNNRIRVRKQDFTLPWEEYGELILENARKSPNSNEEYPRVEDMNEKDSTIPKESPSTDLKNDNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNTSNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK
SIO_010081: YNL136W
subclass of: SO_0000673
so part of: YNL136W
location: 370368..371645
location: region:370368-371645:1
so has part: feature:370368-371645:1:exon

NP_014263.1
type: Protein
SIO_000068: ncbiprotein

S000005080
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370368-371645:1:exon

YNL135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FKB1
alternative label: RBP1
gene: FPR1
locus tag: YNL135C
gene synonym: FKB1; RBP1
so part of: sequence
location: complement(<371882..>372226)
location: region:371882-372226:-1
so has part: feature:371882-372226:-1:exon
subclass of: SO_0000010

855587
type: Gene
SIO_000068: ncbigene

position:371882:-1
position: 371882
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:372226:-1
position: 372226
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371882-372226:-1:exon

YNL135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FKB1
alternative label: RBP1
gene: FPR1
locus tag: YNL135C
gene synonym: FKB1; RBP1
product: peptidylprolyl isomerase FPR1
transcript id: NM_001182973.1
SIO_010081: YNL135C
subclass of: SO_0000673
so part of: YNL135C
location: complement(<371882..>372226)
location: region:371882-372226:-1
so has part: feature:371882-372226:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371882-372226:-1:exon

YNL135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FKB1
alternative label: RBP1
gene: FPR1
locus tag: YNL135C
gene synonym: FKB1; RBP1
EC number: 5.2.1.8
experiment: EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1996117]
experiment: EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]
experiment: EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:8325502]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:34534579]
experiment: EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]
experiment: EXISTENCE:direct assay:GO:1903644 regulation of chaperone-mediated protein folding [PMID:34534579]
experiment: EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:10049913]
experiment: EXISTENCE:genetic interaction:GO:1901710 regulation of homoserine biosynthetic process [PMID:15470257]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:32603360]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:32603360]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9362068]
note: Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A
codon start: 1
product: peptidylprolyl isomerase FPR1
translation: MSEVIEGNVKIDRISPGDGATFPKTGDLVTIHYTGTLENGQKFDSSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLTIPGPYAYGPRGFPGLIPPNSTLVFDVELLKVN
SIO_010081: YNL135C
subclass of: SO_0000673
so part of: YNL135C
location: complement(371882..372226)
location: region:371882-372226:-1
so has part: feature:371882-372226:-1:exon

NP_014264.1
type: Protein
SIO_000068: ncbiprotein

S000005079
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371882-372226:-1:exon

YNL134C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL134C
so part of: sequence
location: complement(<372451..>373581)
location: region:372451-373581:-1
so has part: feature:372451-373581:-1:exon
subclass of: SO_0000010

855588
type: Gene
SIO_000068: ncbigene

position:372451:-1
position: 372451
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:373581:-1
position: 373581
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372451-373581:-1:exon

YNL134C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL134C
product: uncharacterized protein
transcript id: NM_001182972.3
SIO_010081: YNL134C
subclass of: SO_0000673
so part of: YNL134C
location: complement(<372451..>373581)
location: region:372451-373581:-1
so has part: feature:372451-373581:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372451-373581:-1:exon

YNL134C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL134C
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:25656244]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656244]
note: NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MSASIPETMKAVVIENGKAVVKQDIPIPELEEGFVLIKTVAVAGNPTDWKHIDFKIGPQGALLGCDAAGQIVKLGPNVDAARFAIGDYIYGVIHGASVRFPSNGAFAEYSAISSETAYKPAREFRLCGKDKLPEGPVKSLEGAVSLPVSLTTAGMILTHSFGLDMTWKPSKAQRDQPILFWGGATAVGQMLIQLAKKLNGFSKIIVVASRKHEKLLKEYGADELFDYHDADVIEQIKKKYNNIPYLVDCVSNTETIQQVYKCAADDLDATVVQLTVLTEKDIKEEDRRQNVSIEGTLLYLIGGNDVPFGTFTLPADPEYKEAAIKFIKFINPKINDGEIHHIPVKVYKNGLDDIPQLLDDIKHGRNSGEKLVAVLK
SIO_010081: YNL134C
subclass of: SO_0000673
so part of: YNL134C
location: complement(372451..373581)
location: region:372451-373581:-1
so has part: feature:372451-373581:-1:exon

NP_014265.3
type: Protein
SIO_000068: ncbiprotein

S000005078
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372451-373581:-1:exon

YNL133C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FYV6
locus tag: YNL133C
so part of: sequence
location: complement(<374171..>374692)
location: region:374171-374692:-1
so has part: feature:374171-374692:-1:exon
subclass of: SO_0000010

855589
type: Gene
SIO_000068: ncbigene

position:374171:-1
position: 374171
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374692:-1
position: 374692
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374171-374692:-1:exon

YNL133C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FYV6
locus tag: YNL133C
product: Fyv6p
transcript id: NM_001182971.3
SIO_010081: YNL133C
subclass of: SO_0000673
so part of: YNL133C
location: complement(<374171..>374692)
location: region:374171-374692:-1
so has part: feature:374171-374692:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:374171-374692:-1:exon

YNL133C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FYV6
locus tag: YNL133C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]
note: hypothetical protein; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
codon start: 1
product: Fyv6p
translation: MSSTSDNNANSAREKKPLKFVSEGVGNVEAQRIREQVEQKKYEAEYKRKTRKSLRDQLRSNAISKQKQYNGLVRDRESFTRLSKEDLEFYQKSKNELLKKEKELNNYLDVKAINFEKKKKALLMENDSTTNTEKYLETGTSLGSKTQIKGVKTSSPKPKIKVSIKKLGRKLEN
SIO_010081: YNL133C
subclass of: SO_0000673
so part of: YNL133C
location: complement(374171..374692)
location: region:374171-374692:-1
so has part: feature:374171-374692:-1:exon

NP_014266.3
type: Protein
SIO_000068: ncbiprotein

S000005077
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374171-374692:-1:exon

YNCN0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0006W
so part of: sequence
location: 374869..374959
location: region:374869-374959:1
so has part: feature:374869-374959:1:exon
subclass of: SO_0000663

855590
type: Gene
SIO_000068: ncbigene

position:374869:1
position: 374869
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:374959:1
position: 374959
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374869-374959:1:exon

YNCN0006W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0006W
product: tRNA-Phe
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0006W
subclass of: SO_0000673
so part of: YNCN0006W
location: join(374869..374905,374924..374959)
location: region:374869-374959:1
so has part: feature:374869-374905:1:exon
so has part: feature:374924-374959:1:exon

S000006569
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374869-374905:1:exon

position:374905:1
position: 374905
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:374924-374959:1:exon

position:374924:1
position: 374924
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL132W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRA1
gene: KRE33
locus tag: YNL132W
gene synonym: RRA1
so part of: sequence
location: <375321..>378491
location: region:375321-378491:1
so has part: feature:375321-378491:1:exon
subclass of: SO_0000010

855591
type: Gene
SIO_000068: ncbigene

position:375321:1
position: 375321
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:378491:1
position: 378491
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375321-378491:1:exon

YNL132W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRA1
gene: KRE33
locus tag: YNL132W
gene synonym: RRA1
product: ribosome biosynthesis protein KRE33
transcript id: NM_001182970.1
SIO_010081: YNL132W
subclass of: SO_0000673
so part of: YNL132W
location: <375321..>378491
location: region:375321-378491:1
so has part: feature:375321-378491:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:375321-378491:1:exon

YNL132W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRA1
gene: KRE33
locus tag: YNL132W
gene synonym: RRA1
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:28542199]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:28542199]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:15167894]
experiment: EXISTENCE:direct assay:GO:1990883 rRNA cytidine N-acetyltransferase activity [PMID:25086048]
experiment: EXISTENCE:mutant phenotype:GO:0016556 mRNA modification [PMID:31243956]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:12150911|PMID:19806183]
note: Acetyltransferase required for biogenesis of small ribosomal subunit; conserved 18S rRNA cytosine acetyltransferase that modifies tRNAs assisted by adaptor Tan1p; responsible for incorporation of N4-acetylcytidine into mRNAs; human homolog NAT10 implicated in several types of cancer and premature aging
codon start: 1
product: ribosome biosynthesis protein KRE33
translation: MAKKAIDSRIPSLIRNGVQTKQRSIFVIVGDRARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLGFTSHRKKRENKIKKEIKRGTREVNEMDPFESFISNQNIRYVYYKESEKILGNTYGMCILQDFEALTPNLLARTIETVEGGGIVVILLKSMSSLKQLYTMTMDVHARYRTEAHGDVVARFNERFILSLGSNPNCLVVDDELNVLPLSGAKNVKPLPPKEDDELPPKQLELQELKESLEDVQPAGSLVSLSKTVNQAHAILSFIDAISEKTLNFTVALTAGRGRGKSAALGISIAAAVSHGYSNIFVTSPSPENLKTLFEFIFKGFDALGYQEHIDYDIIQSTNPDFNKAIVRVDIKRDHRQTIQYIVPQDHQVLGQAELVVIDEAAAIPLPIVKNLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRNQNNTSGRESTQTAVVSRDNKEKDSHLHSQSRQLREISLDEPIRYAPGDPIEKWLNKLLCLDVTLIKNPRFATRGTPHPSQCNLFVVNRDTLFSYHPVSENFLEKMMALYVSSHYKNSPNDLQLMSDAPAHKLFVLLPPIDPKDGGRIPDPLCVIQIALEGEISKESVRNSLSRGQRAGGDLIPWLISQQFQDEEFASLSGARIVRIATNPEYASMGYGSRAIELLRDYFEGKFTDMSEDVRPKDYSIKRVSDKELAKTNLLKDDVKLRDAKTLPPLLLKLSEQPPHYLHYLGVSYGLTQSLHKFWKNNSFVPVYLRQTANDLTGEHTCVMLNVLEGRESNWLVEFAKDFRKRFLSLLSYDFHKFTAVQALSVIESSKKAQDLSDDEKHDNKELTRTHLDDIFSPFDLKRLDSYSNNLLDYHVIGDMIPMLALLYFGDKMGDSVKLSSVQSAILLAIGLQRKNIDTIAKELNLPSNQTIAMFAKIMRKMSQYFRQLLSQSIEETLPNIKDDAIAEMDGEEIKNYNAAEALDQMEEDLEEAGSEAVQAMREKQKELINSLNLDKYAINDNSEEWAESQKSLEIAAKAKGVVSLKTGKKRTTEKAEDIYRQEMKAMKKPRKSKKAAN
SIO_010081: YNL132W
subclass of: SO_0000673
so part of: YNL132W
location: 375321..378491
location: region:375321-378491:1
so has part: feature:375321-378491:1:exon

NP_014267.1
type: Protein
SIO_000068: ncbiprotein

S000005076
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375321-378491:1:exon

YNL131W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAS17
alternative label: MAS22
alternative label: MOM22
gene: TOM22
locus tag: YNL131W
gene synonym: MAS17; MAS22; MOM22
so part of: sequence
location: <378767..>379225
location: region:378767-379225:1
so has part: feature:378767-379225:1:exon
subclass of: SO_0000010

855592
type: Gene
SIO_000068: ncbigene

position:378767:1
position: 378767
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:379225:1
position: 379225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378767-379225:1:exon

YNL131W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAS17
alternative label: MAS22
alternative label: MOM22
gene: TOM22
locus tag: YNL131W
gene synonym: MAS17; MAS22; MOM22
product: Tom22p
transcript id: NM_001182969.1
SIO_010081: YNL131W
subclass of: SO_0000673
so part of: YNL131W
location: <378767..>379225
location: region:378767-379225:1
so has part: feature:378767-379225:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:378767-379225:1:exon

YNL131W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAS17
alternative label: MAS22
alternative label: MOM22
gene: TOM22
locus tag: YNL131W
gene synonym: MAS17; MAS22; MOM22
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]
experiment: EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:10519552]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:10519552|PMID:9774667]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:12628251]
note: Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel
codon start: 1
product: Tom22p
translation: MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDSDSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTLTTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN
SIO_010081: YNL131W
subclass of: SO_0000673
so part of: YNL131W
location: 378767..379225
location: region:378767-379225:1
so has part: feature:378767-379225:1:exon

NP_014268.1
type: Protein
SIO_000068: ncbiprotein

S000005075
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378767-379225:1:exon

YNL130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CPT1
locus tag: YNL130C
so part of: sequence
location: complement(<379558..>380831)
location: region:379558-380831:-1
so has part: feature:379558-380831:-1:exon
subclass of: SO_0000010

855593
type: Gene
SIO_000068: ncbigene

position:379558:-1
position: 379558
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:380831:-1
position: 380831
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379558-380831:-1:exon

YNL130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CPT1
locus tag: YNL130C
product: diacylglycerol cholinephosphotransferase
transcript id: NM_001182968.3
SIO_010081: YNL130C
subclass of: SO_0000673
so part of: YNL130C
location: complement(join(<379558..380689,380782..>380831))
location: region:379558-380831:-1
so has part: feature:380782-380831:-1:exon
so has part: feature:379558-380689:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380782-380831:-1:exon

position:380782:-1
position: 380782
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:379558-380689:-1:exon

position:380689:-1
position: 380689
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CPT1
locus tag: YNL130C
EC number: 2.7.8.2
experiment: EXISTENCE:direct assay:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8543066]
experiment: EXISTENCE:direct assay:GO:0006657 CDP-choline pathway [PMID:3029130]
experiment: EXISTENCE:mutant phenotype:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]
experiment: EXISTENCE:mutant phenotype:GO:0006657 CDP-choline pathway [PMID:3029130]
note: Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication
codon start: 1
product: diacylglycerol cholinephosphotransferase
translation: MGFFIPQSSLGNLKLYKYQSDDRSFLSNHVLRPFWRKFATIFPLWMAPNLVTLLGFCFIIFNVLTTLYYDPYFDQESPRWTYFSYAIGLFLYQTFDACDGMHARRTGQQGPLGELFDHCIDSINTTLSMIPVCSMTGMGYTYMTIFSQFAILCSFYLSTWEEYHTHKLYLAEFCGPVEGIIVLCISFIAVGIYGPQTIWHTKVAQFSWQDFVFDVETVHLMYAFCTGALIFNIVTAHTNVVRYYESQSTKSATPSKTAENISKAVNGLLPFFAYFSSIFTLVLIQPSFISLALILSIGFSVAFVVGRMIIAHLTMQPFPMVNFPFLIPTIQLVLYAFMVYVLDYQKGSIVSALVWMGLGLTLAIHGMFINDIIYDITTFLDIYALSIKHPKEI
SIO_010081: YNL130C
subclass of: SO_0000673
so part of: YNL130C
location: complement(join(379558..380689,380782..380831))
location: region:379558-380831:-1
so has part: feature:380782-380831:-1:exon
so has part: feature:379558-380689:-1:exon

NP_014269.4
type: Protein
SIO_000068: ncbiprotein

S000005074
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380782-380831:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:379558-380689:-1:exon

YNL130C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DGR1
locus tag: YNL130C-A
so part of: sequence
location: complement(<381245..>381391)
location: region:381245-381391:-1
so has part: feature:381245-381391:-1:exon
subclass of: SO_0000010

1466512
type: Gene
SIO_000068: ncbigene

position:381245:-1
position: 381245
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:381391:-1
position: 381391
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381245-381391:-1:exon

YNL130C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DGR1
locus tag: YNL130C-A
product: Dgr1p
transcript id: NM_001184574.1
SIO_010081: YNL130C-A
subclass of: SO_0000673
so part of: YNL130C-A
location: complement(<381245..>381391)
location: region:381245-381391:-1
so has part: feature:381245-381391:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:381245-381391:-1:exon

YNL130C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DGR1
locus tag: YNL130C-A
note: hypothetical protein; dgr1 null mutant is resistant to 2-deoxy-D-glucose
codon start: 1
product: Dgr1p
translation: MQVGFVSQTNCRSFPACIVFLFQMSQRQRSFNANLRVFKSKCKKIYIG
SIO_010081: YNL130C-A
subclass of: SO_0000673
so part of: YNL130C-A
location: complement(381245..381391)
location: region:381245-381391:-1
so has part: feature:381245-381391:-1:exon

NP_878154.1
type: Protein
SIO_000068: ncbiprotein

S000028579
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381245-381391:-1:exon

YNL129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRK1
locus tag: YNL129W
so part of: sequence
location: <381480..>382202
location: region:381480-382202:1
so has part: feature:381480-382202:1:exon
subclass of: SO_0000010

855594
type: Gene
SIO_000068: ncbigene

position:381480:1
position: 381480
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382202:1
position: 382202
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381480-382202:1:exon

YNL129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRK1
locus tag: YNL129W
product: ribosylnicotinamide kinase
transcript id: NM_001182967.1
SIO_010081: YNL129W
subclass of: SO_0000673
so part of: YNL129W
location: <381480..>382202
location: region:381480-382202:1
so has part: feature:381480-382202:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:381480-382202:1:exon

YNL129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRK1
locus tag: YNL129W
EC number: 2.7.1.22
EC number: 2.7.1.173
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]
experiment: EXISTENCE:direct assay:GO:0050262 ribosylnicotinamide kinase activity [PMID:15137942]
experiment: EXISTENCE:genetic interaction:GO:0009435 NAD biosynthetic process [PMID:17914902]
experiment: EXISTENCE:genetic interaction:GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway [PMID:15137942]
experiment: EXISTENCE:genetic interaction:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]
note: Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
codon start: 1
product: ribosylnicotinamide kinase
translation: MTSKKVILVALSGCSSSGKTTIAKLTASLFTKATLIHEDDFYKHDNEVPVDAKYNIQNWDSPEALDFKLFGKELDVIKQTGKIATKLIHNNNVDDPFTKFHIDRQVWDELKAKYDSINDDKYEVVIVDGFMIFNNTGISKKFDLKILVRAPYEVLKKRRASRKGYQTLDSFWVDPPYYFDEFVYESYRANHAQLFVNGDVEGLLDPRKSKNIKEFINDDDTPIAKPLSWVCQEILKLCKD
SIO_010081: YNL129W
subclass of: SO_0000673
so part of: YNL129W
location: 381480..382202
location: region:381480-382202:1
so has part: feature:381480-382202:1:exon

NP_014270.1
type: Protein
SIO_000068: ncbiprotein

S000005073
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381480-382202:1:exon

YNL128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TEP1
locus tag: YNL128W
so part of: sequence
location: <382359..>383663
location: region:382359-383663:1
so has part: feature:382359-383663:1:exon
subclass of: SO_0000010

855595
type: Gene
SIO_000068: ncbigene

position:382359:1
position: 382359
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:383663:1
position: 383663
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:382359-383663:1:exon

YNL128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TEP1
locus tag: YNL128W
product: putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
transcript id: NM_001182966.4
SIO_010081: YNL128W
subclass of: SO_0000673
so part of: YNL128W
location: <382359..>383663
location: region:382359-383663:1
so has part: feature:382359-383663:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:382359-383663:1:exon

YNL128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TEP1
locus tag: YNL128W
EC number: 3.1.3.67
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15913452]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11070083]
note: PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
codon start: 1
product: putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
translation: MREEGSELEMEKGFLKWKPVNLMKKILSLPMKKTKNDIGLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFITHEKAAQEGISNEAVKFKFKFRLAKMTFLRPSSLITSESAIVTTKIQHYNDDRNALLTRKVVYSDIMAHECGGNMTFIFGRDYLTLENDCRIEFTLGTSKSKAASSIISWTSCASCWLNIYLETLMHIIKDDSSPDYFQVERLKRDEMLGTTISWQELDGFGELSTHGLKLFQALKLEWEII
SIO_010081: YNL128W
subclass of: SO_0000673
so part of: YNL128W
location: 382359..383663
location: region:382359-383663:1
so has part: feature:382359-383663:1:exon

NP_014271.3
type: Protein
SIO_000068: ncbiprotein

S000005072
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:382359-383663:1:exon

YNL127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAR11
locus tag: YNL127W
so part of: sequence
location: <383987..>386848
location: region:383987-386848:1
so has part: feature:383987-386848:1:exon
subclass of: SO_0000010

855596
type: Gene
SIO_000068: ncbigene

position:383987:1
position: 383987
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:386848:1
position: 386848
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:383987-386848:1:exon

YNL127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAR11
locus tag: YNL127W
product: Far11p
transcript id: NM_001182965.3
SIO_010081: YNL127W
subclass of: SO_0000673
so part of: YNL127W
location: <383987..>386848
location: region:383987-386848:1
so has part: feature:383987-386848:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:383987-386848:1:exon

YNL127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAR11
locus tag: YNL127W
experiment: EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:22782902]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22782902]
experiment: EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:22782902]
note: Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B
codon start: 1
product: Far11p
translation: MNASGRSHSKGPIIRSVSLEDLKRNSSFKGNLKYKDEVTSHKEPQVGTLSNEELLKDLDNMLRGKLNMGRNSFHADKRNKSDGNISALTFKARSGLEGDIRTIDIQQDSSDENDNFKFSDDGVNKDRNNEKDNNTDNAVEFQDDAEEAEEENEDESFANVDELDGFDLNKVSDGKHVPINEKGEVDYNMPVDKEFQKSLDQCAASLEERSSAPYALQRAVDWELKMFYSLEDELSEWFCSSDYMHFGQTQTLFKQKITQPQLFFDDENYAASVVECLIEDIPNSLASNLLALSYISMGCFAFTNSKSEHTKIIRRNNLMLVPHIQEIVHAFKKIAISCRDDNRNLKKQTILLFHSSTILYFICSICIEGRGENPEAVNVVIDAFEKTDLLEFLTKYIENWRWNSRLAMRIRNMISLLFKLIVLQFGDSSVYKQTKSSIYNLHGLTYPSKHPEKLSISPLHYQAFREDITSRFPDYNMPSSGLPKDVDKSESLSQFLEIPRPKSKNPLNMALIVPEKHIATPAPSPPSSPQLMHLGEGPRPRKSFQTNMAYPCLYPSDNEGSEDDTLEDRIDLNIERKPDNDIVIPFSTEEAARILSESLEIKLSTKQLWYERDLFMITERGWKQQLENEPYDYAALNHDANSSKEEKSAICIMQRIDKYYKSCLSSFNSLVFVLLQTMESSLTNNFHRKSEVSDKNLLNMLTPQLEIVRAKELSLKSAAGILHALLKWFKLSHILKFEHLAVVIHDSRYINTCASILSKYSEVYPERVFNKYVQTPNSFWKECSLSNESYRESYSVDDSGEVDTEIMPSFAYLLRILRKVTGNKTQRLKELPLSIGILFKRYYRLFNLDMYHPILKITRELTPFKNKRWKSEHMELISGVYLYEKLELTDNWVTGKDISGELSDACGQEIALRALLQFYNFQHYEISMEDLGYGHRNSSSQDLLNKESEYLNI
SIO_010081: YNL127W
subclass of: SO_0000673
so part of: YNL127W
location: 383987..386848
location: region:383987-386848:1
so has part: feature:383987-386848:1:exon

NP_014272.3
type: Protein
SIO_000068: ncbiprotein

S000005071
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:383987-386848:1:exon

YNL126W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC98
locus tag: YNL126W
so part of: sequence
location: <387227..>389767
location: region:387227-389767:1
so has part: feature:387227-389767:1:exon
subclass of: SO_0000010

855597
type: Gene
SIO_000068: ncbigene

position:387227:1
position: 387227
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:389767:1
position: 389767
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387227-389767:1:exon

YNL126W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC98
locus tag: YNL126W
product: Spc98p
transcript id: NM_001182964.1
SIO_010081: YNL126W
subclass of: SO_0000673
so part of: YNL126W
location: <387227..>389767
location: region:387227-389767:1
so has part: feature:387227-389767:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387227-389767:1:exon

YNL126W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC98
locus tag: YNL126W
experiment: EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630]
experiment: EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630]
experiment: EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:11950928|PMID:24842996]
experiment: EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:25599398|PMID:9384578|PMID:9130700]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9153752]
experiment: EXISTENCE:mutant phenotype:GO:0043015 gamma-tubulin binding [PMID:8670895]
experiment: EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]
experiment: EXISTENCE:physical interaction:GO:0043015 gamma-tubulin binding [PMID:8670895|PMID:9130700]
note: Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
codon start: 1
product: Spc98p
translation: MELEPTLFGIIEALAPQLLSQSHLQTFVSDVVNLLRSSTKSATQLGPLIDFYKLQSLDSPETTIMWHKIEKFLDALFGIQNTDDMVKYLSVFQSLLPSNYRAKIVQKSSGLNMENLANHEHLLSPVRAPSIYTEASFENMDRFSERRSMVSSPNRYVPSSTYSSVTLRQLSNPYYVNTIPEEDILKYVSYTLLATTSALFPFDHEQIQIPSKIPNFESGLLHLIFEAGLLYQSLGYKVEKFRMLNISPMKKALIIEISEELQNYTAFVNNLVSSGTVVSLKSLYREIYENIIRLRIYCRFTEHLEELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDTNGTDDDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHVLYQSNSYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDALIEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDVFTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQKEMLKSNDIIRSFKKIRGYNPLIRDIINKLSRISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLIRLNNGTIELNGILTPKAEVLTKSSSSKPQKHAIEKTLNIDELESVHNTFLTNILSHKLFATNTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDIGYEIFIKMNLNDHEASNGLLGKFNTNLKEIVSQYKNFKDRLYIFRADLKNDGDEELFLLSKSLR
SIO_010081: YNL126W
subclass of: SO_0000673
so part of: YNL126W
location: 387227..389767
location: region:387227-389767:1
so has part: feature:387227-389767:1:exon

NP_014273.1
type: Protein
SIO_000068: ncbiprotein

S000005070
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387227-389767:1:exon

YNL125C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MCH3
gene: ESBP6
locus tag: YNL125C
gene synonym: MCH3
so part of: sequence
location: complement(<390146..>392167)
location: region:390146-392167:-1
so has part: feature:390146-392167:-1:exon
subclass of: SO_0000010

855598
type: Gene
SIO_000068: ncbigene

position:390146:-1
position: 390146
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:392167:-1
position: 392167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390146-392167:-1:exon

YNL125C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MCH3
gene: ESBP6
locus tag: YNL125C
gene synonym: MCH3
product: Esbp6p
transcript id: NM_001182963.1
SIO_010081: YNL125C
subclass of: SO_0000673
so part of: YNL125C
location: complement(<390146..>392167)
location: region:390146-392167:-1
so has part: feature:390146-392167:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390146-392167:-1:exon

YNL125C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MCH3
gene: ESBP6
locus tag: YNL125C
gene synonym: MCH3
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11536335]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
codon start: 1
product: Esbp6p
translation: MSTHSNDYFSASSGMVSETSSEVSSINSSQPVSFSKASIAAPVPCSDLHSTKSNDASRKLSISRTLTNRLNDIKKAVDDDNLQTEENSADVNKILESRFDVADAIRLQHNESVQSKLNIPVTHTTTAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLMRNRLYPASTKHSGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIALLKERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMMVFTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVTIVLTTLLTIYMFAFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLVCEVIAQALTVEKDKSNPYLHAQIFCGCCFIAALILISILREYSIRMKLTERQAMTNEKLKEWKASEYDTDSADEDWGKLKERKTKYDLLLGPGIKKYFLRMVYPMKV
SIO_010081: YNL125C
subclass of: SO_0000673
so part of: YNL125C
location: complement(390146..392167)
location: region:390146-392167:-1
so has part: feature:390146-392167:-1:exon

NP_014274.1
type: Protein
SIO_000068: ncbiprotein

S000005069
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390146-392167:-1:exon

YNL124W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAF1
locus tag: YNL124W
so part of: sequence
location: <392892..>394370
location: region:392892-394370:1
so has part: feature:392892-394370:1:exon
subclass of: SO_0000010

855599
type: Gene
SIO_000068: ncbigene

position:392892:1
position: 392892
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394370:1
position: 394370
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392892-394370:1:exon

YNL124W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAF1
locus tag: YNL124W
product: RNA-binding snoRNP assembly protein
transcript id: NM_001182962.3
SIO_010081: YNL124W
subclass of: SO_0000673
so part of: YNL124W
location: <392892..>394370
location: region:392892-394370:1
so has part: feature:392892-394370:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392892-394370:1:exon

YNL124W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAF1
locus tag: YNL124W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12515383]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12242285|PMID:12515383]
experiment: EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:12228251|PMID:12242285|PMID:12515383]
experiment: EXISTENCE:physical interaction:GO:0000493 box H/ACA snoRNP assembly [PMID:12228251|PMID:12515383]
experiment: EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:12515383]
note: RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
codon start: 1
product: RNA-binding snoRNP assembly protein
translation: MSDDLFSKALENPDQDLNVELPKDDVDLGLLGDGGNERKTDEPVADAERSTGLGSGSSESESDSGSDSDSDSGSSGSEDDSADQDVEGEDEGGDAIENEDEDEDPSPSGPILSKNEILEETVPELPEDYEISEKTIITPIGVLKSAFENNIIIHATMSGEKRVLKEGSIFCLEDRTLIGMLTEVFGPLQNPFYRIKLPDSKKNLFDELKVRLGEKAFIVTPDAHWIDTFELKRNKGTDASNGYDEELPEEEQEFSDDEKEALFKKMKKQQRQRKKRDNRKLANDSDNVKVKRARQPKANSLPKLVPPLGMSSNAPMQHGYKSRNARENIKRESSATSNRNGSSPVPITQHHQQQFSANNYPFPQQPNGMPYPPYSPFPQPTNFQYPPPPFGQATPAQFSNTVPYGSLPPAYNNMSPPTQQSFMPMTQSQPPLPYGVPPMNQMQNPMYIQPPPQAPPQGNGNFQQVMELHQILLQQQQQQHQYQHQHQQDPRT
SIO_010081: YNL124W
subclass of: SO_0000673
so part of: YNL124W
location: 392892..394370
location: region:392892-394370:1
so has part: feature:392892-394370:1:exon

NP_014275.3
type: Protein
SIO_000068: ncbiprotein

S000005068
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392892-394370:1:exon

YNL123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNM3
gene: NMA111
locus tag: YNL123W
gene synonym: YNM3
so part of: sequence
location: <394685..>397678
location: region:394685-397678:1
so has part: feature:394685-397678:1:exon
subclass of: SO_0000010

855600
type: Gene
SIO_000068: ncbigene

position:394685:1
position: 394685
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397678:1
position: 397678
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394685-397678:1:exon

YNL123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNM3
gene: NMA111
locus tag: YNL123W
gene synonym: YNM3
product: Nma111p
transcript id: NM_001182961.1
SIO_010081: YNL123W
subclass of: SO_0000673
so part of: YNL123W
location: <394685..>397678
location: region:394685-397678:1
so has part: feature:394685-397678:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394685-397678:1:exon

YNL123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNM3
gene: NMA111
locus tag: YNL123W
gene synonym: YNM3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14657274|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008236 serine-type peptidase activity [PMID:18946088]
experiment: EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:29861160]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:14657274|PMID:16470384|PMID:16608876]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:18946088]
experiment: EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:18946088]
experiment: EXISTENCE:mutant phenotype:GO:0044255 cellular lipid metabolic process [PMID:16470384]
experiment: EXISTENCE:mutant phenotype:GO:0051438 regulation of ubiquitin-protein transferase activity [PMID:29861160]
experiment: EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]
experiment: EXISTENCE:physical interaction:GO:0044255 cellular lipid metabolic process [PMID:16470384]
note: Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member
codon start: 1
product: Nma111p
translation: MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYTDHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHAITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDNKETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDTTGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSADILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVKYDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIPRYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIMDCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNIVDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGISATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPTAELKRDNITHKWIEKEFTGNSQSEK
SIO_010081: YNL123W
subclass of: SO_0000673
so part of: YNL123W
location: 394685..397678
location: region:394685-397678:1
so has part: feature:394685-397678:1:exon

NP_014276.1
type: Protein
SIO_000068: ncbiprotein

S000005067
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394685-397678:1:exon

YNL122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bL35m
gene: MRP35
locus tag: YNL122C
gene synonym: bL35m
so part of: sequence
location: complement(<398023..>398370)
location: region:398023-398370:-1
so has part: feature:398023-398370:-1:exon
subclass of: SO_0000010

855601
type: Gene
SIO_000068: ncbigene

position:398023:-1
position: 398023
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:398370:-1
position: 398370
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:398023-398370:-1:exon

YNL122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bL35m
gene: MRP35
locus tag: YNL122C
gene synonym: bL35m
product: Mrp35p
transcript id: NM_001182960.1
SIO_010081: YNL122C
subclass of: SO_0000673
so part of: YNL122C
location: complement(<398023..>398370)
location: region:398023-398370:-1
so has part: feature:398023-398370:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:398023-398370:-1:exon

YNL122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bL35m
gene: MRP35
locus tag: YNL122C
gene synonym: bL35m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:24675956]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]
note: Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins
codon start: 1
product: Mrp35p
translation: MKISLHNKRQRGDQNQNMSVFNVLKPLLKGSNSFKVKLNGFLFNNVSTITIRTLMKTHKGTAKRWRRTGNTFKRGIAGRKHGNIGWSHRSLKALTGRKIAHPAYSKHLKRLLPYH
SIO_010081: YNL122C
subclass of: SO_0000673
so part of: YNL122C
location: complement(398023..398370)
location: region:398023-398370:-1
so has part: feature:398023-398370:-1:exon

NP_014277.1
type: Protein
SIO_000068: ncbiprotein

S000005066
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:398023-398370:-1:exon

YNL121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAS70
alternative label: MOM72
alternative label: OMP1
gene: TOM70
locus tag: YNL121C
gene synonym: MAS70; MOM72; OMP1
so part of: sequence
location: complement(<398684..>400537)
location: region:398684-400537:-1
so has part: feature:398684-400537:-1:exon
subclass of: SO_0000010

855602
type: Gene
SIO_000068: ncbigene

position:398684:-1
position: 398684
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400537:-1
position: 400537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:398684-400537:-1:exon

YNL121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAS70
alternative label: MOM72
alternative label: OMP1
gene: TOM70
locus tag: YNL121C
gene synonym: MAS70; MOM72; OMP1
product: protein channel TOM70
transcript id: NM_001182959.3
SIO_010081: YNL121C
subclass of: SO_0000673
so part of: YNL121C
location: complement(<398684..>400537)
location: region:398684-400537:-1
so has part: feature:398684-400537:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:398684-400537:-1:exon

YNL121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAS70
alternative label: MOM72
alternative label: OMP1
gene: TOM70
locus tag: YNL121C
gene synonym: MAS70; MOM72; OMP1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]
experiment: EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]
experiment: EXISTENCE:genetic interaction:GO:0006626 protein targeting to mitochondrion [PMID:18007655]
experiment: EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:2177474]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8132642]
experiment: EXISTENCE:mutant phenotype:GO:0030943 mitochondrion targeting sequence binding [PMID:11054285]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]
note: Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially-directed proteins, acting as a receptor for incoming precursor proteins; moonlighting role as a transcriptional regulator of mitochondrial proteins; age-dependent reduction in Tom70p results in mitochondrial dysfunction, a hallmark of aging; TOM70 has a paralog, TOM71, that arose from the whole genome duplication
codon start: 1
product: protein channel TOM70
translation: MKSFITRNKTAILATVAATGTAIGAYYYYNQLQQQQQRGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALELKEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFNDASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFKPELTFANYDESNEADKELMNGLSNLYKRSPESYDKADESFTKAARLFEEQLDKNNEDEKLKEKLAISLEHTGIFKFLKNDPLGAHEDIKKAIELFPRVNSYIYMALIMADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQLACLAYRENKFDDCETLFSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELENKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDIDEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKKIQETLAKLREQGLM
SIO_010081: YNL121C
subclass of: SO_0000673
so part of: YNL121C
location: complement(398684..400537)
location: region:398684-400537:-1
so has part: feature:398684-400537:-1:exon

NP_014278.3
type: Protein
SIO_000068: ncbiprotein

S000005065
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:398684-400537:-1:exon

YNL119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TUC2
gene: NCS2
locus tag: YNL119W
gene synonym: TUC2
so part of: sequence
location: <401040..>402521
location: region:401040-402521:1
so has part: feature:401040-402521:1:exon
subclass of: SO_0000010

855603
type: Gene
SIO_000068: ncbigene

position:401040:1
position: 401040
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402521:1
position: 402521
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401040-402521:1:exon

YNL119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TUC2
gene: NCS2
locus tag: YNL119W
gene synonym: TUC2
product: Ncs2p
transcript id: NM_001182957.3
SIO_010081: YNL119W
subclass of: SO_0000673
so part of: YNL119W
location: <401040..>402521
location: region:401040-402521:1
so has part: feature:401040-402521:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:401040-402521:1:exon

YNL119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TUC2
gene: NCS2
locus tag: YNL119W
gene synonym: TUC2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]
experiment: EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:17018299|PMID:18755837|PMID:19151091|PMID:18664566|P MID:19145231]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14551258]
experiment: EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]
note: Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
codon start: 1
product: Ncs2p
translation: MECQRCPASARNPATVESRKEKFCDECFIKFVSTKQRKQMMKDEYFRNLFKVIYPFEKEGSVSKILLPLSHSDSGSLVMLDIVHDLLLEQTKQHNNRTGFTVDVLTVFTEENVSVIKERMESLINEKMSQLNKISNIFNVHFIDVNEFFNNASEVSTFIIDNENFEIFSKSKSVDDSNILTLKEILGKYCLNNSSRSDLISIIKTQLIKHFAYENGYNAIMWGHSMTKLSEVIISLVVKGKGSQIATFLDSESFDTLNNKPCKYKNLYPMKDLLSVEIESFLQIRNLAQFLINVEETNVKPNCLIARKSLPSLGQQKLVKNMTINEITNKYFQDIQNDYSNIISTVLRTADKLTQPKSSMAKPSQCQICQSKIYTNPSNWLNRITVTSPYPVETTEEKYLFKQWQDSKLGQSHTHYVELLNEIKQGASNSLDVEDGDVKLCYGCLILLNTSIKDKNLVWPKVDTMDITANATNKNKELSQILDQFEINSDGEE
SIO_010081: YNL119W
subclass of: SO_0000673
so part of: YNL119W
location: 401040..402521
location: region:401040-402521:1
so has part: feature:401040-402521:1:exon

NP_014280.3
type: Protein
SIO_000068: ncbiprotein

S000005063
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401040-402521:1:exon

YNL118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSU1
gene: DCP2
locus tag: YNL118C
gene synonym: PSU1
so part of: sequence
location: complement(<402652..>405564)
location: region:402652-405564:-1
so has part: feature:402652-405564:-1:exon
subclass of: SO_0000010

855605
type: Gene
SIO_000068: ncbigene

position:402652:-1
position: 402652
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:405564:-1
position: 405564
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402652-405564:-1:exon

YNL118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSU1
gene: DCP2
locus tag: YNL118C
gene synonym: PSU1
product: decapping enzyme complex catalytic subunit
transcript id: NM_001182956.1
SIO_010081: YNL118C
subclass of: SO_0000673
so part of: YNL118C
location: complement(<402652..>405564)
location: region:402652-405564:-1
so has part: feature:402652-405564:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402652-405564:-1:exon

YNL118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSU1
gene: DCP2
locus tag: YNL118C
gene synonym: PSU1
EC number: 3.6.1.62
experiment: EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173|PMID:11139489]
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23509072|PMID:12730603]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11139489]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0016787 hydrolase activity [PMID:12486012]
experiment: EXISTENCE:direct assay:GO:0050072 m7G(5')pppN diphosphatase activity [PMID:16341225]
experiment: EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]
experiment: EXISTENCE:direct assay:GO:0098745 Dcp1-Dcp2 complex [PMID:12554866]
experiment: EXISTENCE:genetic interaction:GO:0034063 stress granule assembly [PMID:20513766]
experiment: EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173]
experiment: EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15225544]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:20513766]
experiment: EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:23706738]
experiment: EXISTENCE:physical interaction:GO:0098745 Dcp1-Dcp2 complex [PMID:10508173]
note: Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress; human homolog DCP2 complements yeast dcp2 thermosensitive mutant
codon start: 1
product: decapping enzyme complex catalytic subunit
translation: MSLPLRHALENVTSVDRILEDLLVRFIINCPNEDLSSVERELFHFEEASWFYTDFIKLMNPTLPSLKIKSFAQLIIKLCPLVWKWDIRVDEALQQFSKYKKSIPVRGAAIFNENLSKILLVQGTESDSWSFPRGKISKDENDIDCCIREVKEEIGFDLTDYIDDNQFIERNIQGKNYKIFLISGVSEVFNFKPQVRNEIDKIEWFDFKKISKTMYKSNIKYYLINSMMRPLSMWLRHQRQIKNEDQLKSYAEEQLKLLLGITKEEQIDPGRELLNMLHTAVQANSNNNAVSNGQVPSSQELQHLKEQSGEHNQQKDQQSSFSSQQQPSIFPSLSEPFANNKNVIPPTMPMANVFMSNPQLFATMNGQPFAPFPFMLPLTNNSNSANPIPTPVPPNFNAPPNPMAFGVPNMHNLSGPAVSQPFSLPPAPLPRDSGYSSSSPGQLLDILNSKKPDSNVQSSKKPKLKILQRGTDLNSIKQNNNDETAHSNSQALLDLLKKPTSSQKIHASKPDTSFLPNDSVSGIQDAEYEDFESSSDEEVETARDERNSLNVDIGVNVMPSEKDSRRSQKEKPRNDASKTNLNASAESNSVEWGPGKSSPSTQSKQNSSVGMQNKYRQEIHIGDSDAYEVFESSSDEEDGKKLEELEQTQDNSKLISQDILKENNFQDGEVPHRDMPTESNKSINETVGLSSTTNTVKKVPKVKILKRGETFASLANDKKAFDSSSNVSSSKDLLQMLRNPISSTVSSNQQSPKSQHLSGDEEIMMMLKRNSVSKPQNSEENASTSSINDANASELLGMLKQKEKDITAPKQPYNVDSYSQKNSAKGLLNILKKNDSTGYPRTEGGPSSEMSTSMKRNDATNNQELDKNSTELLNYLKPKPLNDGYENISNKDSSHELLNILHGNKNSSAFNNNVYATDGYSLASDNNENSSNKLLNMLQNRSSAINEPNFDVRSNGTSGSNELLSILHRK
SIO_010081: YNL118C
subclass of: SO_0000673
so part of: YNL118C
location: complement(402652..405564)
location: region:402652-405564:-1
so has part: feature:402652-405564:-1:exon

NP_014281.1
type: Protein
SIO_000068: ncbiprotein

S000005062
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402652-405564:-1:exon

YNL117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MLS1
locus tag: YNL117W
so part of: sequence
location: <406358..>408022
location: region:406358-408022:1
so has part: feature:406358-408022:1:exon
subclass of: SO_0000010

855606
type: Gene
SIO_000068: ncbigene

position:406358:1
position: 406358
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:408022:1
position: 408022
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:406358-408022:1:exon

YNL117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MLS1
locus tag: YNL117W
product: malate synthase MLS1
transcript id: NM_001182955.1
SIO_010081: YNL117W
subclass of: SO_0000673
so part of: YNL117W
location: <406358..>408022
location: region:406358-408022:1
so has part: feature:406358-408022:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:406358-408022:1:exon

YNL117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MLS1
locus tag: YNL117W
EC number: 2.3.3.9
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:2211514|PMID:27678487]
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:11846793]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11846793|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0004474 malate synthase activity [PMID:8878673|PMID:23642236]
experiment: EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:8878673|PMID:23642236]
note: Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA
codon start: 1
product: malate synthase MLS1
translation: MVKVSLDNVKLLVDVDKEPFFKPSSTTVGDILTKDALEFIVLLHRTFNNKRKQLLENRQVVQKKLDSGSYHLDFLPETANIRNDPTWQGPILAPGLINRSTEITGPPLRNMLINALNAPVNTYMTDFEDSASPTWNNMVYGQVNLYDAIRNQIDFDTPRKSYKLNGNVANLPTIIVRPRGWHMVEKHLYVDDEPISASIFDFGLYFYHNAKELIKLGKGPYFYLPKMEHHLEAKLWNDVFCVAQDYIGIPRGTIRATVLIETLPAAFQMEEIIYQLRQHSSGLNCGRWDYIFSTIKRLRNDPNHILPNRNQVTMTSPFMDAYVKRLINTCHRRGVHAMGGMAAQIPIKDDPAANEKAMTKVRNDKIRELTNGHDGSWVAHPALAPICNEVFINMGTPNQIYFIPENVVTAANLLETKIPNGEITTEGIVQNLDIGLQYMEAWLRGSGCVPINNLMEDAATAEVSRCQLYQWVKHGVTLKDTGEKVTPELTEKILKEQVERLSKASPLGDKNKFALAAKYFLPEIRGEKFSEFLTTLLYDEIVSTKATPTDLSKL
SIO_010081: YNL117W
subclass of: SO_0000673
so part of: YNL117W
location: 406358..408022
location: region:406358-408022:1
so has part: feature:406358-408022:1:exon

NP_014282.1
type: Protein
SIO_000068: ncbiprotein

S000005061
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:406358-408022:1:exon

YNL116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHF2
gene: DMA2
locus tag: YNL116W
gene synonym: CHF2
so part of: sequence
location: <408341..>409909
location: region:408341-409909:1
so has part: feature:408341-409909:1:exon
subclass of: SO_0000010

855607
type: Gene
SIO_000068: ncbigene

position:408341:1
position: 408341
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:409909:1
position: 409909
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408341-409909:1:exon

YNL116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHF2
gene: DMA2
locus tag: YNL116W
gene synonym: CHF2
product: ubiquitin-conjugating protein DMA2
transcript id: NM_001182954.3
SIO_010081: YNL116W
subclass of: SO_0000673
so part of: YNL116W
location: <408341..>409909
location: region:408341-409909:1
so has part: feature:408341-409909:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:408341-409909:1:exon

YNL116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHF2
gene: DMA2
locus tag: YNL116W
gene synonym: CHF2
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:18202552]
experiment: EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21562220]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:22570619]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]
experiment: EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:23442799]
experiment: EXISTENCE:mutant phenotype:GO:0032177 cellular bud neck split septin rings [PMID:23442799]
experiment: EXISTENCE:mutant phenotype:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]
experiment: EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]
note: Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-conjugating protein DMA2
translation: MYTPIPANTPAPTAPTSSMTSNSSSASNANTTSSSGINPRNRASGTPSNERARPASGISSFLNTFGIRQNSQTASSSAAPDQRLFGTTPSNSHMSVAMESIDTAPQQQEPRLHHPIQMPLSAQFHVHRNYQLPISISLTAPTTTDHQQSSAHNFEGNNVGNVQESLNQRQPNGTNNTTTSIISMAPAATTRNIVGGADGSTIVNNSQEMYKNLRHLIYAANQPNGTEILHLDLPATSAEESNNMFNVDEVTLKQRKDKHGLFSIRLTPFIDSSSTTNQGLFFEPIIRKAGPGSQLVIGRYTERVRDAISKIPEQYHPVVFKSKVVSRTHGCFKVDSQGNWYIKDVKSSSGTFLNHQRLSPASSLSKDTPLRDGDILQLGMDFRGGTEEIYRCVRMRIELNRSWKLKANSFNKEALQRLQNLQKLTTGIEEEDCSICLCKIKPCQAIFISPCAHSWHFRCVRRLVMLSYPQFVCPNCRSSCDLEASFESSDEEDESDVESEGDQLVDQLSVLMETSKDVDSHP
SIO_010081: YNL116W
subclass of: SO_0000673
so part of: YNL116W
location: 408341..409909
location: region:408341-409909:1
so has part: feature:408341-409909:1:exon

NP_014283.3
type: Protein
SIO_000068: ncbiprotein

S000005060
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:408341-409909:1:exon

YNL115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL115C
so part of: sequence
location: complement(<410119..>412053)
location: region:410119-412053:-1
so has part: feature:410119-412053:-1:exon
subclass of: SO_0000010

855608
type: Gene
SIO_000068: ncbigene

position:410119:-1
position: 410119
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412053:-1
position: 412053
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410119-412053:-1:exon

YNL115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL115C
product: uncharacterized protein
transcript id: NM_001182953.1
SIO_010081: YNL115C
subclass of: SO_0000673
so part of: YNL115C
location: complement(<410119..>412053)
location: region:410119-412053:-1
so has part: feature:410119-412053:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410119-412053:-1:exon

YNL115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL115C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MKANGLDNDPARTGMERTDIDSEHPEAQPLLNNNHRTLGAGSANGPAVNEGRDIESDGFIKDSLFQIRKGYRIFIHNSKWILNILILINTIWLVTTLISDFFFNINILFGFSNRYASFNDLTLIFISIIANSFNLWFNKLGLYSALDYSLNVTLCVLTLFNLALTYLIKYTRQRIGFVGTFTYLWTSFSFFIGAILDWYLLFYNNSINEPLEERRIDDANISTFNENHTNSTENRDRSQYGSGSPTPTHRSQLVQNKHTLTEWVSIGFRNTIKFLILIFFALFTLNTLLTTLDTYRLTHKLPITVQSPSYEAFHYVDAAKTYQLHITCYGDVFDQENNTDLSENKKQPIILFEHGGYDTGYLSATWIEELYHLDKIQRYCLYDRPGYGLSDSPPAPISIAMVAESLRYALIKDAKIKGPFTTVGYDLGGLFTRVFTAKNVDIVDSMMLVESWHEELLLKNYIQRLLPPGRGDGDDGDDGNGNDGDGRNHDKTWLPSEIERHNEFRLWWKGIWSSLGWRLQTSWLLAHHGSKERIYGRDMKYQGRFLRSKFLESVTSSILSYRDVTNNAESLQNVKTSIVSSKEMVKKSALWGDWQRDLTKISHKTQEWKIVEGGHEIYKYGLGKQQTQEVLLRLIGELGKLTED
SIO_010081: YNL115C
subclass of: SO_0000673
so part of: YNL115C
location: complement(410119..412053)
location: region:410119-412053:-1
so has part: feature:410119-412053:-1:exon

NP_014284.1
type: Protein
SIO_000068: ncbiprotein

S000005059
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410119-412053:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1417; Autonomously Replicating Sequence
so part of: sequence
location: 412267..412496
location: region:412267-412496:1
so has part: feature:412267-412496:1:region

S000118386
type: SGD
SIO_000068: sgd

position:412267:1
position: 412267
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:412496:1
position: 412496
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412267-412496:1:region

YNL113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPC19
locus tag: YNL113W
so part of: sequence
location: <412771..>413199
location: region:412771-413199:1
so has part: feature:412771-413199:1:exon
subclass of: SO_0000010

855609
type: Gene
SIO_000068: ncbigene

position:412771:1
position: 412771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:413199:1
position: 413199
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412771-413199:1:exon

YNL113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPC19
locus tag: YNL113W
product: DNA-directed RNA polymerase core subunit RPC19
transcript id: NM_001182951.1
SIO_010081: YNL113W
subclass of: SO_0000673
so part of: YNL113W
location: <412771..>413199
location: region:412771-413199:1
so has part: feature:412771-413199:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:412771-413199:1:exon

YNL113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPC19
locus tag: YNL113W
experiment: EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:9837969|PMID:11486042]
experiment: EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
note: RNA polymerase subunit AC19; common to RNA polymerases I and III
codon start: 1
product: DNA-directed RNA polymerase core subunit RPC19
translation: MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKGLKDLMDLCDVVESKFTEKIKSM
SIO_010081: YNL113W
subclass of: SO_0000673
so part of: YNL113W
location: 412771..413199
location: region:412771-413199:1
so has part: feature:412771-413199:1:exon

NP_014286.1
type: Protein
SIO_000068: ncbiprotein

S000005057
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:412771-413199:1:exon

YNL112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DBP2
locus tag: YNL112W
so part of: sequence
location: <413639..>416281
location: region:413639-416281:1
so has part: feature:413639-416281:1:exon
subclass of: SO_0000010

855611
type: Gene
SIO_000068: ncbigene

position:413639:1
position: 413639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416281:1
position: 416281
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413639-416281:1:exon

YNL112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DBP2
locus tag: YNL112W
product: DEAD-box ATP-dependent RNA helicase DBP2
transcript id: NM_001182950.3
SIO_010081: YNL112W
subclass of: SO_0000673
so part of: YNL112W
location: join(<413639..414911,415914..>416281)
location: region:413639-416281:1
so has part: feature:413639-414911:1:exon
so has part: feature:415914-416281:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413639-414911:1:exon

position:414911:1
position: 414911
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:415914-416281:1:exon

position:415914:1
position: 415914
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DBP2
locus tag: YNL112W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23721653]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:30902808]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22679025|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:30902808]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:30902808]
experiment: EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11585918]
experiment: EXISTENCE:mutant phenotype:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]
experiment: EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]
experiment: EXISTENCE:mutant phenotype:GO:1990120 messenger ribonucleoprotein complex assembly [PMID:23721653]
experiment: EXISTENCE:physical interaction:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:7883168]
note: ATP-dependent RNA helicase of the DEAD-box protein family; has strong preference for dsRNA; remodels RNA-protein complex (RNP) to facilitate efficient transcription termination; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
codon start: 1
product: DEAD-box ATP-dependent RNA helicase DBP2
translation: MTYGGRDQQYNKTNYKSRGGDFRGGRNSDRNSYNDRPQGGNYRGGFGGRSNYNQPQELIKPNWDEELPKLPTFEKNFYVEHESVRDRSDSEIAQFRKENEMTISGHDIPKPITTFDEAGFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRDMVGIAATGSGKTLSYCLPGIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQTECSKFGHSSRIRNTCVYGGVPKSQQIRDLSRGSEIVIATPGRLIDMLEIGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVKQLAADYLNDPIQVQVGSLELSASHNITQIVEVVSDFEKRDRLNKYLETASQDNEYKTLIFASTKRMCDDITKYLREDGWPALAIHGDKDQRERDWVLQEFRNGRSPIMVATDVAARGIDVKGINYVINYDMPGNIEDYVHRIGRTGRAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPELLKYDRRSYGGGHPRYGGGRGGRGGYGRRGGYGGGRGGYGGNRQRDGGWGNRGRSNY
SIO_010081: YNL112W
subclass of: SO_0000673
so part of: YNL112W
location: join(413639..414911,415914..416281)
location: region:413639-416281:1
so has part: feature:413639-414911:1:exon
so has part: feature:415914-416281:1:exon

NP_014287.3
type: Protein
SIO_000068: ncbiprotein

S000005056
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413639-414911:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:415914-416281:1:exon

YNL111C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CYB5
locus tag: YNL111C
so part of: sequence
location: complement(<416940..>417302)
location: region:416940-417302:-1
so has part: feature:416940-417302:-1:exon
subclass of: SO_0000010

855612
type: Gene
SIO_000068: ncbigene

position:416940:-1
position: 416940
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:417302:-1
position: 417302
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:416940-417302:-1:exon

YNL111C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CYB5
locus tag: YNL111C
product: Cyb5p
transcript id: NM_001182949.3
SIO_010081: YNL111C
subclass of: SO_0000673
so part of: YNL111C
location: complement(<416940..>417302)
location: region:416940-417302:-1
so has part: feature:416940-417302:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:416940-417302:-1:exon

YNL111C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CYB5
locus tag: YNL111C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]
experiment: EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:10622712]
experiment: EXISTENCE:direct assay:GO:0016126 sterol biosynthetic process [PMID:10622712]
note: Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
codon start: 1
product: Cyb5p
translation: MPKVYSYQEVAEHNGPENFWIIIDDKVYDVSQFKDEHPGGDEIIMDLGGQDATESFVDIGHSDEALRLLKGLYIGDVDKTSERVSVEKVSTSENQSKGSGTLVVILAILMLGVAYYLLNE
SIO_010081: YNL111C
subclass of: SO_0000673
so part of: YNL111C
location: complement(416940..417302)
location: region:416940-417302:-1
so has part: feature:416940-417302:-1:exon

NP_014288.3
type: Protein
SIO_000068: ncbiprotein

S000005055
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:416940-417302:-1:exon

YNL110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP15
locus tag: YNL110C
so part of: sequence
location: complement(<417826..>418488)
location: region:417826-418488:-1
so has part: feature:417826-418488:-1:exon
subclass of: SO_0000010

855613
type: Gene
SIO_000068: ncbigene

position:417826:-1
position: 417826
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:418488:-1
position: 418488
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417826-418488:-1:exon

YNL110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP15
locus tag: YNL110C
product: rRNA-binding ribosome biosynthesis protein NOP15
transcript id: NM_001182948.1
SIO_010081: YNL110C
subclass of: SO_0000673
so part of: YNL110C
location: complement(<417826..>418488)
location: region:417826-418488:-1
so has part: feature:417826-418488:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417826-418488:-1:exon

YNL110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP15
locus tag: YNL110C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10953080]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11583614]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21811236]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
note: Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
codon start: 1
product: rRNA-binding ribosome biosynthesis protein NOP15
translation: MVKSTSKTSTKETVTKQPTEEKPIQEKEELALETSSSSSDEEDEKDEDEIEGLAASDDEQSGTHKIKRLNPKKQANEKKSKDKKTLEEYSGIIYVSRLPHGFHEKELSKYFAQFGDLKEVRLARNKKTGNSRHYGFLEFVNKEDAMIAQESMNNYLLMGHLLQVRVLPKGAKIEKLYKYKKRVLVEKGITKPVKQLKDNMKQKHEERIKKLAKSGIEFKW
SIO_010081: YNL110C
subclass of: SO_0000673
so part of: YNL110C
location: complement(417826..418488)
location: region:417826-418488:-1
so has part: feature:417826-418488:-1:exon

NP_014289.1
type: Protein
SIO_000068: ncbiprotein

S000005054
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417826-418488:-1:exon

YNL108C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HUF
locus tag: YNL108C
gene synonym: HUF
so part of: sequence
location: complement(<419014..>419826)
location: region:419014-419826:-1
so has part: feature:419014-419826:-1:exon
subclass of: SO_0000010

855615
type: Gene
SIO_000068: ncbigene

position:419014:-1
position: 419014
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:419826:-1
position: 419826
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:419014-419826:-1:exon

YNL108C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HUF
locus tag: YNL108C
gene synonym: HUF
product: uncharacterized protein
transcript id: NM_001182946.1
SIO_010081: YNL108C
subclass of: SO_0000673
so part of: YNL108C
location: complement(<419014..>419826)
location: region:419014-419826:-1
so has part: feature:419014-419826:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:419014-419826:-1:exon

YNL108C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HUF
locus tag: YNL108C
gene synonym: HUF
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016311 dephosphorylation [PMID:23569204]
experiment: EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:23569204]
note: Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MAIENIYIARHGYRSNWLPKGPYPPPPTGIDNDVPLSEHGVEQAHELANYISKLDVKPEMIFSSPFYRCLETSKPTVEALKIPLYVDRGVGEWYKPDRPIIPEPATHEVMSKFFPSMISPDWEPSIIPSNKGETEEDIFERCHKFWPVFIDRVERKFPNVKTIMIVTHAATKSALGMNLLKFSSAKEPIDNKGTFIRNGSCAIDKFELVKGENESIPFEEREWKLTMNGNTSFLTNGEEMNWTFMNAFEAGSDADIKARRAAESGKLKME
SIO_010081: YNL108C
subclass of: SO_0000673
so part of: YNL108C
location: complement(419014..419826)
location: region:419014-419826:-1
so has part: feature:419014-419826:-1:exon

NP_014291.1
type: Protein
SIO_000068: ncbiprotein

S000005052
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:419014-419826:-1:exon

YNL107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YAF9
locus tag: YNL107W
so part of: sequence
location: <420098..>420778
location: region:420098-420778:1
so has part: feature:420098-420778:1:exon
subclass of: SO_0000010

855616
type: Gene
SIO_000068: ncbigene

position:420098:1
position: 420098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420778:1
position: 420778
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:420098-420778:1:exon

YNL107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YAF9
locus tag: YNL107W
product: YEATS domain-containing protein YAF9
transcript id: NM_001182945.3
SIO_010081: YNL107W
subclass of: SO_0000673
so part of: YNL107W
location: <420098..>420778
location: region:420098-420778:1
so has part: feature:420098-420778:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:420098-420778:1:exon

YNL107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YAF9
locus tag: YNL107W
experiment: EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15485911]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15302830]
note: Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain
codon start: 1
product: YEATS domain-containing protein YAF9
translation: MAPTISKRIKTLSVSRPIIYGNTAKKMGSVKPPNAPAEHTHLWTIFVRGPQNEDISYFIKKVVFKLHDTYPNPVRSIEAPPFELTETGWGEFDINIKVYFVEEANEKVLNFYHRLRLHPYANPVPNSDNGNEQNTTDHNSKDAEVSSVYFDEIVFNEPNEEFFKILMSRPGNLLPSNKTDDCVYSKQLEQEEIDRIEIGIEKVDKEIDELKQKLENLVKQEAINGS
SIO_010081: YNL107W
subclass of: SO_0000673
so part of: YNL107W
location: 420098..420778
location: region:420098-420778:1
so has part: feature:420098-420778:1:exon

NP_014292.3
type: Protein
SIO_000068: ncbiprotein

S000005051
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:420098-420778:1:exon

YNL106C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SJL2
gene: INP52
locus tag: YNL106C
gene synonym: SJL2
so part of: sequence
location: complement(<420944..>424495)
location: region:420944-424495:-1
so has part: feature:420944-424495:-1:exon
subclass of: SO_0000010

855618
type: Gene
SIO_000068: ncbigene

position:420944:-1
position: 420944
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:424495:-1
position: 424495
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:420944-424495:-1:exon

YNL106C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SJL2
gene: INP52
locus tag: YNL106C
gene synonym: SJL2
product: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52
transcript id: NM_001182944.1
SIO_010081: YNL106C
subclass of: SO_0000673
so part of: YNL106C
location: complement(<420944..>424495)
location: region:420944-424495:-1
so has part: feature:420944-424495:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:420944-424495:-1:exon

YNL106C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SJL2
gene: INP52
locus tag: YNL106C
gene synonym: SJL2
EC number: 3.1.3.36
experiment: EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11094088]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:15798181|PMID:11094088]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:10224048]
experiment: EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]
experiment: EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131]
experiment: EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9438131]
experiment: EXISTENCE:physical interaction:GO:0030479 actin cortical patch [PMID:15798181]
note: Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52
translation: MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN
SIO_010081: YNL106C
subclass of: SO_0000673
so part of: YNL106C
location: complement(420944..424495)
location: region:420944-424495:-1
so has part: feature:420944-424495:-1:exon

NP_014293.1
type: Protein
SIO_000068: ncbiprotein

S000005050
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:420944-424495:-1:exon

YNL104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LEU4
locus tag: YNL104C
so part of: sequence
location: complement(<424895..>426754)
location: region:424895-426754:-1
so has part: feature:424895-426754:-1:exon
subclass of: SO_0000010

855619
type: Gene
SIO_000068: ncbigene

position:424895:-1
position: 424895
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426754:-1
position: 426754
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424895-426754:-1:exon

YNL104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LEU4
locus tag: YNL104C
product: 2-isopropylmalate synthase LEU4
transcript id: NM_001182942.1
SIO_010081: YNL104C
subclass of: SO_0000673
so part of: YNL104C
location: complement(<424895..>426754)
location: region:424895-426754:-1
so has part: feature:424895-426754:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:424895-426754:-1:exon

YNL104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LEU4
locus tag: YNL104C
EC number: 2.3.3.13
experiment: EXISTENCE:direct assay:GO:0003852 2-isopropylmalate synthase activity [PMID:25841022|PMID:3275644]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:3275644|PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:3275644|PMID:25841022|PMID:14562095|PMID:24769239|PM ID:11914276|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0009098 leucine biosynthetic process [PMID:10790691]
experiment: EXISTENCE:mutant phenotype:GO:0009098 leucine biosynthetic process [PMID:25841022]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:25841022]
note: Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
codon start: 1
product: 2-isopropylmalate synthase LEU4
translation: MVKESIIALAEHAASRASRVIPPVKLAYKNMLKDPSSKYKPFNAPKLSNRKWPDNRITRAPRWLSTDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAPDDVSIQCLVQSREHLIKRTVEALTGAKKATIHTYLATSDMFREIVFNMSREEAISKAVEATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFNLPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEGCLFGNGERTGNVDLVTVAMNMYTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYGGDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQSGKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKSDEISKLFKEAYNYNDEQYQAISLVNYNVEKFGTERRVFTGQVKVGDQIVDIEGTGNGPISSLVDALSNLLNVRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKWGVGVSEDVGDSSVRAIFATINNIIHSGDVSIPSLAEVEGKNAAASGSA
SIO_010081: YNL104C
subclass of: SO_0000673
so part of: YNL104C
location: complement(424895..426754)
location: region:424895-426754:-1
so has part: feature:424895-426754:-1:exon

NP_014295.1
type: Protein
SIO_000068: ncbiprotein

S000005048
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424895-426754:-1:exon

YNL103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MET4
locus tag: YNL103W
so part of: sequence
location: <427735..>429753
location: region:427735-429753:1
so has part: feature:427735-429753:1:exon
subclass of: SO_0000010

855620
type: Gene
SIO_000068: ncbigene

position:427735:1
position: 427735
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:429753:1
position: 429753
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427735-429753:1:exon

YNL103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MET4
locus tag: YNL103W
product: Met4p
transcript id: NM_001182941.3
SIO_010081: YNL103W
subclass of: SO_0000673
so part of: YNL103W
location: <427735..>429753
location: region:427735-429753:1
so has part: feature:427735-429753:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427735-429753:1:exon

YNL103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MET4
locus tag: YNL103W
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9799240]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9799240]
experiment: EXISTENCE:direct assay:GO:0046685 response to arsenic-containing substance [PMID:15689486]
experiment: EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:15689486]
experiment: EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]
experiment: EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1549123]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:9799240]
note: Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; can be ubiquitinated by ubiquitin ligase SCF-Met30p, is either degraded or maintained in an inactive state; regulates degradation of its own DNA-binding cofactors by targeting them to SCF-Met30p
codon start: 1
product: Met4p
translation: MKQEQSHEGDSYSTEFINLFGKDTATHPSSNNGANNNGMGSTNSLDQFVATASSSSSLVTSSENRRPLIGDVTNRGNTNLYDHAVTPEILLEQLAYVDNFIPSLDNEFSNVDWNVNTTHNNANNNGADTFSSINANPFDLDEQLAIELSAFADDSFIFPDEDKPSNNNNNSNNGNDDHSNHDVLHEDPSTNNRQRNPHFLTQRRNTFLTSQYDQSKSRFSSKNKRNGNNGETNNFGDNMQNNHPFEPNFMGSPSQFPADATNMTSIDHGGFTNVDITSTENNTTGDNGVDALSNLLHRTTHTPNRSSPLSNVTSAQNSSSQQRKHSESKVDSNSDNNSSNKAPNITVPDYSIIPTSVLVTLLPRVNVPNGAYNSLISAGFDNDQIDAIAAIMAYHHQKKIRENNSNNNKNINTNDSQEAPILKNINELLSVLIPPSPAETAAPTTLSTSPSFNEHGVVAEASFLSSILELGIKHPKSNNIHNQRQPSRNDHKISRESDGNNGNDNVHHNNAVIKSSTTRGDEIAKIRSEPTLNASSSDHKENSLKRSHSGDLKNKKVPVDRKYSDNEDDEYDDADLHGFEKKQLIKKELGDDDEDLLIQSKKSHQKKKLKEKELESSIHELTEIAASLQKRIHTLETENKLLKNLVLSSGETEGIKKAESLKKQIFEKVQKE
SIO_010081: YNL103W
subclass of: SO_0000673
so part of: YNL103W
location: 427735..429753
location: region:427735-429753:1
so has part: feature:427735-429753:1:exon

NP_014296.4
type: Protein
SIO_000068: ncbiprotein

S000005047
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427735-429753:1:exon

YNL102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC17
alternative label: CRT5
alternative label: HPR3
gene: POL1
locus tag: YNL102W
gene synonym: CDC17; CRT5; HPR3
so part of: sequence
location: <430087..>434493
location: region:430087-434493:1
so has part: feature:430087-434493:1:exon
subclass of: SO_0000010

855621
type: Gene
SIO_000068: ncbigene

position:430087:1
position: 430087
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:434493:1
position: 434493
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:430087-434493:1:exon

YNL102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC17
alternative label: CRT5
alternative label: HPR3
gene: POL1
locus tag: YNL102W
gene synonym: CDC17; CRT5; HPR3
product: DNA-directed DNA polymerase alpha catalytic subunit POL1
transcript id: NM_001182940.3
SIO_010081: YNL102W
subclass of: SO_0000673
so part of: YNL102W
location: <430087..>434493
location: region:430087-434493:1
so has part: feature:430087-434493:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:430087-434493:1:exon

YNL102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC17
alternative label: CRT5
alternative label: HPR3
gene: POL1
locus tag: YNL102W
gene synonym: CDC17; CRT5; HPR3
EC number: 2.7.7.7
experiment: EXISTENCE:curator inference:GO:0006270 DNA replication initiation [PMID:3888995]
experiment: EXISTENCE:curator inference:GO:0006273 lagging strand elongation [PMID:3888995]
experiment: EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:1704371|PMID:3888995|PMID:3907855]
experiment: EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893]
experiment: EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]
experiment: EXISTENCE:mutant phenotype:GO:0000731 DNA synthesis involved in DNA repair [PMID:2651896]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2651896]
experiment: EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:2651896]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]
note: Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
codon start: 1
product: DNA-directed DNA polymerase alpha catalytic subunit POL1
translation: MSSKSEKLEKLRKLQAARNGTSIDDYEGDESDGDRIYDEIDEKEYRARKRQELLHDDFVVDDDGVGYVDRGVEEDWREVDNSSSDEDTGNLASKDSKRKKNIKREKDHQITDMLRTQHSKSTLLAHAKKSQKKSIPIDNFDDILGEFESGEVEKPNILLPSKLRENLNSSPTSEFKSSIKRVNGNDESSHDAGISKKVKIDPDSSTDKYLEIESSPLKLQSRKLRYANDVQDLLDDVENSPVVATKRQNVLQDTLLANPPSAQSLADEEDDEDSDEDIILKRRTMRSVTTTRRVNIDSRSNPSTSPFVTAPGTPIGIKGLTPSKSLQSNTDVATLAVNVKKEDVVDPETDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREGKTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLLPYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIKGADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPKENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAALAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIANEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPVNSKKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKDPKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALSVAERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKYFRREGGNNNGEDINNLQPLETTITDVERFKDTVTLELSCPSCDKRFPFGGIVSSNYYRVSYNGLQCKHCEQLFTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGIVTRQVSVFGKRCLNDGCTGVMRYKYSDKQLYNQLLYFDSLFDCEKNKKQELKPIYLPDDLDYPKEQLTESSIKALTEQNRELMETGRSVVQKYLNDCGRRYVDMTSIFDFMLN
SIO_010081: YNL102W
subclass of: SO_0000673
so part of: YNL102W
location: 430087..434493
location: region:430087-434493:1
so has part: feature:430087-434493:1:exon

NP_014297.3
type: Protein
SIO_000068: ncbiprotein

S000005046
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:430087-434493:1:exon

YNL101W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVT4
locus tag: YNL101W
so part of: sequence
location: <434999..>437140
location: region:434999-437140:1
so has part: feature:434999-437140:1:exon
subclass of: SO_0000010

855622
type: Gene
SIO_000068: ncbigene

position:434999:1
position: 434999
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437140:1
position: 437140
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434999-437140:1:exon

YNL101W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVT4
locus tag: YNL101W
product: Avt4p
transcript id: NM_001182939.1
SIO_010081: YNL101W
subclass of: SO_0000673
so part of: YNL101W
location: <434999..>437140
location: region:434999-437140:1
so has part: feature:434999-437140:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:434999-437140:1:exon

YNL101W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVT4
locus tag: YNL101W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]
experiment: EXISTENCE:genetic interaction:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]
note: Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)
codon start: 1
product: Avt4p
translation: MVTNNGDGEHLGIRRNGNLRHPSNNMKIPRRAQSTVLNSNPFYSRKYSMSTLTPRDICRSVDSRVFVDMSSPNFQTLEDPHRDEIINSVRLNYLNSSKRSSVSHGNEAIPRVNPTKNSSASTIAAANVDSDDDETNLSSAGGDITHDIYKLVKAEDPKRLRRPRSMENVTPKIEHHTKLSSASGLNVPGGFRREFIVNKKRQEHQLNDSASSDFTSHESDSINQSSPSSNQDIDKVPFLTRNFLEFLYVFGHFAGESFEDDFIPDSSNMMIRGEDERSALLSRPDHMKVLPSAKGTTSTKKVFLILLKSFIGTGVLFLPNAFHNGGLFFSVSMLAFFGIYSYWCYYILVQAKSSCGVSSFGDIGLKLYGPWMRIIILFSLVITQVGFSGAYMIFTAKNLQAFLDNVFHVGVLPLSYLMVFQTIIFIPLSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLFIGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTVILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKFFPKFTKIYVKHDDLTTRVELRPNSGKLNWKIKWLKNFIRSIIVIIVVSIAYFGSDNLDKFVSVIGSLACIPLVYIYPSMLHLRGNSLPETKGEFWRFKPMLDTILIFFGIASMLYTSYQSIFGV
SIO_010081: YNL101W
subclass of: SO_0000673
so part of: YNL101W
location: 434999..437140
location: region:434999-437140:1
so has part: feature:434999-437140:1:exon

NP_014298.1
type: Protein
SIO_000068: ncbiprotein

S000005045
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434999-437140:1:exon

YNL100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM37
alternative label: MCS27
gene: MIC27
locus tag: YNL100W
gene synonym: AIM37; MCS27
so part of: sequence
location: <437613..>438317
location: region:437613-438317:1
so has part: feature:437613-438317:1:exon
subclass of: SO_0000010

855623
type: Gene
SIO_000068: ncbigene

position:437613:1
position: 437613
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:438317:1
position: 438317
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437613-438317:1:exon

YNL100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM37
alternative label: MCS27
gene: MIC27
locus tag: YNL100W
gene synonym: AIM37; MCS27
product: Mic27p
transcript id: NM_001182938.1
SIO_010081: YNL100W
subclass of: SO_0000673
so part of: YNL100W
location: <437613..>438317
location: region:437613-438317:1
so has part: feature:437613-438317:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437613-438317:1:exon

YNL100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM37
alternative label: MCS27
gene: MIC27
locus tag: YNL100W
gene synonym: AIM37; MCS27
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23509072]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]
experiment: EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21944719|PMID:21987634|PMID:22009199]
experiment: EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:21944719|PMID:21987634|PMID:22009199]
experiment: EXISTENCE:mutant phenotype:GO:0043933 protein-containing complex organization [PMID:26968360]
note: Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; orthologous to human APOO and APOOL
codon start: 1
product: Mic27p
translation: MVNFYDDVDESKSHGEFPLIPVVLQNSSELSVRTIPTGNEIIESVHLTKWLRKYRNALASQLDRYEKGWQSKIANFRLQVQHVINYSRKNIFNVDSENKHTVVPGSLIALGAFFAGSIAVNRSNWGAKRLIFGHKSSILEKLCTSLPSRILLPWVLAAATFKYWAPQTSQNLVNATENDLLPADFVKSYHNTWKRIYEEGYVAKKCDLKRQIDQTLQKNIRYAREQLYEKLEQA
SIO_010081: YNL100W
subclass of: SO_0000673
so part of: YNL100W
location: 437613..438317
location: region:437613-438317:1
so has part: feature:437613-438317:1:exon

NP_014299.1
type: Protein
SIO_000068: ncbiprotein

S000005044
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437613-438317:1:exon

YNL099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OCA1
locus tag: YNL099C
so part of: sequence
location: complement(<438567..>439283)
location: region:438567-439283:-1
so has part: feature:438567-439283:-1:exon
subclass of: SO_0000010

855624
type: Gene
SIO_000068: ncbigene

position:438567:-1
position: 438567
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439283:-1
position: 439283
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438567-439283:-1:exon

YNL099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OCA1
locus tag: YNL099C
product: putative tyrosine protein phosphatase OCA1
transcript id: NM_001182937.3
SIO_010081: YNL099C
subclass of: SO_0000673
so part of: YNL099C
location: complement(<438567..>439283)
location: region:438567-439283:-1
so has part: feature:438567-439283:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:438567-439283:-1:exon

YNL099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OCA1
locus tag: YNL099C
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11408586]
note: Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA
codon start: 1
product: putative tyrosine protein phosphatase OCA1
translation: MTSKVGEYEDVPEDESRLTEENVSVPEEEVEDEDEEEDDDDDHIYINEETESGREKVLVSHAPQERIVPPLNFCPVERYLYRSGQPSPVNFPFLLNLKLKTIIWLSNEEPQDTLLEFCDTHRINLQFAAINPDAGEDDNPWDGLTEHSIINVLQTIVTQENYPLLVCCGMGRHRTGTVIGCLRRIMGWNLASVSEEYRRFTGSRGGRILVELLIEAFDTNLVKIDKNKAPSWLLTALE
SIO_010081: YNL099C
subclass of: SO_0000673
so part of: YNL099C
location: complement(438567..439283)
location: region:438567-439283:-1
so has part: feature:438567-439283:-1:exon

NP_014300.3
type: Protein
SIO_000068: ncbiprotein

S000005043
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438567-439283:-1:exon

YNL098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTN5
alternative label: CYR3
alternative label: GLC5
alternative label: TSL7
gene: RAS2
locus tag: YNL098C
gene synonym: CTN5; CYR3; GLC5; TSL7
so part of: sequence
location: complement(<439602..>440570)
location: region:439602-440570:-1
so has part: feature:439602-440570:-1:exon
subclass of: SO_0000010

855625
type: Gene
SIO_000068: ncbigene

position:439602:-1
position: 439602
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440570:-1
position: 440570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439602-440570:-1:exon

YNL098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTN5
alternative label: CYR3
alternative label: GLC5
alternative label: TSL7
gene: RAS2
locus tag: YNL098C
gene synonym: CTN5; CYR3; GLC5; TSL7
product: Ras family GTPase RAS2
transcript id: NM_001182936.1
SIO_010081: YNL098C
subclass of: SO_0000673
so part of: YNL098C
location: complement(<439602..>440570)
location: region:439602-440570:-1
so has part: feature:439602-440570:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439602-440570:-1:exon

YNL098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTN5
alternative label: CYR3
alternative label: GLC5
alternative label: TSL7
gene: RAS2
locus tag: YNL098C
gene synonym: CTN5; CYR3; GLC5; TSL7
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8106517]
experiment: EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:6438624]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23127800]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22575457|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20162532|PMID:23127800|PMID:16622836|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0007190 activation of adenylate cyclase activity [PMID:8106517]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:15016820]
experiment: EXISTENCE:genetic interaction:GO:0045762 positive regulation of adenylate cyclase activity [PMID:2981630|PMID:3891097]
experiment: EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]
experiment: EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:16292676]
experiment: EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2558958]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:15016820]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:15917658]
experiment: EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:1547504|PMID:8643578]
note: GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication
codon start: 1
product: Ras family GTPase RAS2
translation: MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS
SIO_010081: YNL098C
subclass of: SO_0000673
so part of: YNL098C
location: complement(439602..440570)
location: region:439602-440570:-1
so has part: feature:439602-440570:-1:exon

NP_014301.1
type: Protein
SIO_000068: ncbiprotein

S000005042
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439602-440570:-1:exon

YNL097C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNL097C-A
gene: PLS1
locus tag: YNL097C-B
gene synonym: YNL097C-A
so part of: sequence
location: complement(<440797..>440919)
location: region:440797-440919:-1
so has part: feature:440797-440919:-1:exon
subclass of: SO_0000010

1466513
type: Gene
SIO_000068: ncbigene

position:440797:-1
position: 440797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440919:-1
position: 440919
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440797-440919:-1:exon

YNL097C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNL097C-A
gene: PLS1
locus tag: YNL097C-B
gene synonym: YNL097C-A
product: Pls1p
transcript id: NM_001184620.1
SIO_010081: YNL097C-B
subclass of: SO_0000673
so part of: YNL097C-B
location: complement(<440797..>440919)
location: region:440797-440919:-1
so has part: feature:440797-440919:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440797-440919:-1:exon

YNL097C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNL097C-A
gene: PLS1
locus tag: YNL097C-B
gene synonym: YNL097C-A
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:35563734]
experiment: EXISTENCE:mutant phenotype:GO:1902986 regulation of lysine biosynthetic process via aminoadipic acid [PMID:35563734]
note: Peroxisomal matrix protein that regulates lysine biosynthesis; localization to peroxisomes upon lysine deprivation is dependent on targeting factor Pex5p and lysine biosynthesis enzyme Lys1p; affects abundance of Lys1p and the lysine biosynthesis pathway
codon start: 1
product: Pls1p
translation: MTAKTKQSWNKGIWENGKQGSHQQTFLPKIWVNIYSTPTS
SIO_010081: YNL097C-B
subclass of: SO_0000673
so part of: YNL097C-B
location: complement(440797..440919)
location: region:440797-440919:-1
so has part: feature:440797-440919:-1:exon

NP_878155.1
type: Protein
SIO_000068: ncbiprotein

S000028699
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440797-440919:-1:exon

YNL097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHO23
locus tag: YNL097C
so part of: sequence
location: complement(<441366..>442358)
location: region:441366-442358:-1
so has part: feature:441366-442358:-1:exon
subclass of: SO_0000010

855626
type: Gene
SIO_000068: ncbigene

position:441366:-1
position: 441366
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442358:-1
position: 442358
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441366-442358:-1:exon

YNL097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHO23
locus tag: YNL097C
product: Pho23p
transcript id: NM_001182935.3
SIO_010081: YNL097C
subclass of: SO_0000673
so part of: YNL097C
location: complement(<441366..>442358)
location: region:441366-442358:-1
so has part: feature:441366-442358:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441366-442358:-1:exon

YNL097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHO23
locus tag: YNL097C
experiment: EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:12672825]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16286008|PMID:16314178|PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003|PMID:24881874]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10805724]
experiment: EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:24881874]
experiment: EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:20398213]
experiment: EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]
experiment: EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]
experiment: EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]
experiment: EXISTENCE:mutant phenotype:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:24881874]
note: Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3
codon start: 1
product: Pho23p
translation: MSSPANLFPGLNDITDVLEEFPLATSRYLTLLHEIDAKCVHSMPNLNERIDKFLKKDFNKDHQTQVRLLNNINKIYEELMPSLEEKMHVSSIMLDNLDRLTSRLELAYEVAIKNTEIPRGLRLGVDNHPAMHLHHELMEKIESKSNSKSSQALKSESRREAMAANRRQGEHYSASTHQQDDSKNDANYGGSRHESQDHTGNNTNSRKRANAANTNNADPETKKRKRRVATTAVSPSTISTATAVNNGRIGTSTASRGVSSVGNSNNSRISRPKTNDYGEPLYCYCNQVAYGEMVGCDGADCELEWFHLPCIGLETLPKGKWYCDDCKKKL
SIO_010081: YNL097C
subclass of: SO_0000673
so part of: YNL097C
location: complement(441366..442358)
location: region:441366-442358:-1
so has part: feature:441366-442358:-1:exon

NP_014302.3
type: Protein
SIO_000068: ncbiprotein

S000005041
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441366-442358:-1:exon

YNCN0007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0007W
so part of: sequence
location: 443006..443119
location: region:443006-443119:1
so has part: feature:443006-443119:1:exon
subclass of: SO_0000663

855627
type: Gene
SIO_000068: ncbigene

position:443006:1
position: 443006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:443119:1
position: 443119
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443006-443119:1:exon

YNCN0007W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0007W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0007W
subclass of: SO_0000673
so part of: YNCN0007W
location: join(443006..443043,443076..443119)
location: region:443006-443119:1
so has part: feature:443006-443043:1:exon
so has part: feature:443076-443119:1:exon

S000006645
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443006-443043:1:exon

position:443043:1
position: 443043
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:443076-443119:1:exon

position:443076:1
position: 443076
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL096C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS7B
locus tag: YNL096C
so part of: sequence
location: complement(<443398..>444315)
location: region:443398-444315:-1
so has part: feature:443398-444315:-1:exon
subclass of: SO_0000010

855628
type: Gene
SIO_000068: ncbigene

position:443398:-1
position: 443398
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:444315:-1
position: 444315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443398-444315:-1:exon

YNL096C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS7B
locus tag: YNL096C
product: ribosomal 40S subunit protein S7B
transcript id: NM_001182934.3
SIO_010081: YNL096C
subclass of: SO_0000673
so part of: YNL096C
location: complement(join(<443398..443826,444172..>444315))
location: region:443398-444315:-1
so has part: feature:444172-444315:-1:exon
so has part: feature:443398-443826:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:444172-444315:-1:exon

position:444172:-1
position: 444172
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:443398-443826:-1:exon

position:443826:-1
position: 443826
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL096C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS7B
locus tag: YNL096C
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]
experiment: EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: ribosomal 40S subunit protein S7B
translation: MSSVQSKILSQAPSELELQVAKTFIDLESSSPELKADLRPLQIKSIREIDVTGGKKALVLFVPVPALSAYHKVQTKLTRELEKKFPDRHVIFLAERRILPKPSRTSRQVQKRPRSRTLTAVHDKVLEDMVFPTEIVGKRVRYLVGGNKIQKVLLDSKDVQQIDYKLESFQAVYNKLTGKQIVFEIPSQTN
SIO_010081: YNL096C
subclass of: SO_0000673
so part of: YNL096C
location: complement(join(443398..443826,444172..444315))
location: region:443398-444315:-1
so has part: feature:444172-444315:-1:exon
so has part: feature:443398-443826:-1:exon

NP_014303.3
type: Protein
SIO_000068: ncbiprotein

S000005040
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:444172-444315:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:443398-443826:-1:exon

YNL095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL095C
so part of: sequence
location: complement(<444912..>446840)
location: region:444912-446840:-1
so has part: feature:444912-446840:-1:exon
subclass of: SO_0000010

855629
type: Gene
SIO_000068: ncbigene

position:444912:-1
position: 444912
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:446840:-1
position: 446840
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:444912-446840:-1:exon

YNL095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL095C
product: uncharacterized protein
transcript id: NM_001182933.1
SIO_010081: YNL095C
subclass of: SO_0000673
so part of: YNL095C
location: complement(<444912..>446840)
location: region:444912-446840:-1
so has part: feature:444912-446840:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:444912-446840:-1:exon

YNL095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL095C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MVHITLGQAIWVSVKPIIKIYLIIGVGFLMAKMGILTVEATRIISDIVLTVLLPSLSFNKIVANIEDKDIKSVGIICLSALLIFGSGFFFAYVVRLFLPVPKQWYGGILAGGMFPNISDLPIAYLQSMDQGLVFSEEEGNKGVANVIIFLTMFLICIFNLGGFRLIESDFEYNDDESAVRVSETTKTQPAVSANTTNTDTSERFFSNEQQLFNNKYTARDSLTEAIGTKGENADVPPISRRSTNSIAPLSLPDTSSNSKITKPVQVKARNTIACTQSEESQATRGSNPLDSQSSASTIHSYNTSESYESSIDTMRARRTASQPRAYNTTTLLEENCLDEKCPKNMSMAALEPIRSIDMRALPSQNIHHLIREYSNVDQYGHQRRNSSLRGADMNDVHSISSNSTLQTIKTANLTRILTSDATVSKKDIETSGESLPQWMRKFSLTPLLVFFLKNCLRPCSMAVIIALTVAFIPWVKALFVTTANTPHISQAPDNAPPLSFFMDFTGYVGAACVPFGLILLGATLGRLKIGNLYPGFWKAAVTLVILRQCVMPIFGVLWCDRLVKAGWVNWQDDRMLLFVIAISWNLPTMTTLIYFTASFTPPETTAPIQMECVSFFLMLQYPLMVVSLPFLVSYFLKVQMNL
SIO_010081: YNL095C
subclass of: SO_0000673
so part of: YNL095C
location: complement(444912..446840)
location: region:444912-446840:-1
so has part: feature:444912-446840:-1:exon

NP_014304.1
type: Protein
SIO_000068: ncbiprotein

S000005039
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:444912-446840:-1:exon

YNL094W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APP1
locus tag: YNL094W
so part of: sequence
location: <447611..>449374
location: region:447611-449374:1
so has part: feature:447611-449374:1:exon
subclass of: SO_0000010

855630
type: Gene
SIO_000068: ncbigene

position:447611:1
position: 447611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449374:1
position: 449374
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447611-449374:1:exon

YNL094W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APP1
locus tag: YNL094W
product: phosphatidate phosphatase APP1
transcript id: NM_001182932.1
SIO_010081: YNL094W
subclass of: SO_0000673
so part of: YNL094W
location: <447611..>449374
location: region:447611-449374:1
so has part: feature:447611-449374:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447611-449374:1:exon

YNL094W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APP1
locus tag: YNL094W
EC number: 3.1.3.4
experiment: EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:23071111|PMID:23335564]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11489916]
experiment: EXISTENCE:mutant phenotype:GO:0008195 phosphatidate phosphatase activity [PMID:23071111]
experiment: EXISTENCE:mutant phenotype:GO:0044255 cellular lipid metabolic process [PMID:23071111]
note: Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
codon start: 1
product: phosphatidate phosphatase APP1
translation: MNSQGYDESSSSTAATSGPTSGDPRMGKKQRFMNLIRTTKDVYIPNLTSSISQKTMDGIRSTTNSFEGYNDLPMELPHNTTITYFPTYTTTNLVDPDGLSAPRKDFETTVRCAVSYPGNPTSRRNRWLLSLCKQYLRTGTAEADVAPVVPPHLEEDSGDLNDSQSSIESSLSSKSENRYSHMGIQEEDVLNERIQGFLSKKVPNTPVVVDLLPKDKLRGDTASFFGTTDSYGNLLIKAETDFLPSKINITLDTPIEGHADPISETFPANYVSPYGIGLISDIDDTIKHTGVTGDRRSMFRNVFIHDVQSWVIDGVPLWYKTLHDVADVDFFYVSNSPIQTFTLLKQYICANFPPGPIFLKQYSGNFFSTIMTSSANRKIQPIANILKDFPKKKFILVGDSGEHDLEAYTTTALQFPNQILAIYIRCCSNSMSDVPSHDEEVMNEVNNIIELQQRPMQMTKSTVRTRRRPPPPPIPSTQKPSLTEEQTESIRMSRRNKDENNAKRVAPPPLPNRQLPNLDANTYYVPSSQNDYGMYGAFMDKKADEWKRRVMDSIQKLSNQDTTLMFFSDPALSLEDSIRRIREKYSN
SIO_010081: YNL094W
subclass of: SO_0000673
so part of: YNL094W
location: 447611..449374
location: region:447611-449374:1
so has part: feature:447611-449374:1:exon

NP_014305.1
type: Protein
SIO_000068: ncbiprotein

S000005038
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447611-449374:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1419; Autonomously Replicating Sequence
so part of: sequence
location: 449429..449588
location: region:449429-449588:1
so has part: feature:449429-449588:1:region

S000118387
type: SGD
SIO_000068: sgd

position:449429:1
position: 449429
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:449588:1
position: 449588
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449429-449588:1:region

YNL093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPT53
locus tag: YNL093W
so part of: sequence
location: <449868..>450530
location: region:449868-450530:1
so has part: feature:449868-450530:1:exon
subclass of: SO_0000010

855631
type: Gene
SIO_000068: ncbigene

position:449868:1
position: 449868
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:450530:1
position: 450530
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449868-450530:1:exon

YNL093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPT53
locus tag: YNL093W
product: Rab family GTPase YPT53
transcript id: NM_001182931.3
SIO_010081: YNL093W
subclass of: SO_0000673
so part of: YNL093W
location: <449868..>450530
location: region:449868-450530:1
so has part: feature:449868-450530:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:449868-450530:1:exon

YNL093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPT53
locus tag: YNL093W
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:22748138]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]
note: Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
codon start: 1
product: Rab family GTPase YPT53
translation: MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAFLTKRITRDGKVIKFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSFYKAQNWVEELHEKVGHDIVIALVGNKMDLLNNDDENENRAMKAPAVQNLCERENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHDRTITDNQRIDLESTTVESTRETGGCNC
SIO_010081: YNL093W
subclass of: SO_0000673
so part of: YNL093W
location: 449868..450530
location: region:449868-450530:1
so has part: feature:449868-450530:1:exon

NP_014306.3
type: Protein
SIO_000068: ncbiprotein

S000005037
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:449868-450530:1:exon

YNL092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL092W
so part of: sequence
location: <450871..>452073
location: region:450871-452073:1
so has part: feature:450871-452073:1:exon
subclass of: SO_0000010

855632
type: Gene
SIO_000068: ncbigene

position:450871:1
position: 450871
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:452073:1
position: 452073
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450871-452073:1:exon

YNL092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL092W
product: S-adenosylmethionine-dependent methyltransferase
transcript id: NM_001182930.1
SIO_010081: YNL092W
subclass of: SO_0000673
so part of: YNL092W
location: <450871..>452073
location: region:450871-452073:1
so has part: feature:450871-452073:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450871-452073:1:exon

YNL092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL092W
EC number: 2.1.1.22
experiment: EXISTENCE:direct assay:GO:0006479 protein methylation [PMID:24651469]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:24651469]
note: S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene
codon start: 1
product: S-adenosylmethionine-dependent methyltransferase
translation: MDENEFDNQRENKAVARVIISFLKYEEYALKEIYNLRVKKWASISDRQKDMVPNYTKYLANLKAAIIENGKFFRSVAEYALQSISFEPGEIVQPNDLDMSKTCSLLTQVYREWSAEAISERNCLNSRLVPFLKTLSPPKADILIPGCGTGRLLVDLSRMGYNCEGNEFSYHMLLVSQYMLNAGLLQNQIIIYPFIHCFSHWKKIEDQLSPIKVPDIEAWSSNKGMGSMSICAGSFVDCYGRNQGTKISSHYTFSRRMQLSRAKAENSKDVVVTNFFIDTGSNILDYLDTIGHVLKPGGIWCNFGPLLYHFENDHGVETTYEVNPYSGFQDKINDYTPLMGLELSSDDIISIATNHLDFELIRRESGILCGYGRYAGPESCAMPGYMCHYWILKSNPTNES
SIO_010081: YNL092W
subclass of: SO_0000673
so part of: YNL092W
location: 450871..452073
location: region:450871-452073:1
so has part: feature:450871-452073:1:exon

NP_014307.1
type: Protein
SIO_000068: ncbiprotein

S000005036
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450871-452073:1:exon

YNL091W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NST1
locus tag: YNL091W
so part of: sequence
location: <452408..>456130
location: region:452408-456130:1
so has part: feature:452408-456130:1:exon
subclass of: SO_0000010

855633
type: Gene
SIO_000068: ncbigene

position:452408:1
position: 452408
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:456130:1
position: 456130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:452408-456130:1:exon

YNL091W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NST1
locus tag: YNL091W
product: Nst1p
transcript id: NM_001182929.1
SIO_010081: YNL091W
subclass of: SO_0000673
so part of: YNL091W
location: <452408..>456130
location: region:452408-456130:1
so has part: feature:452408-456130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:452408-456130:1:exon

YNL091W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NST1
locus tag: YNL091W
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:34347506]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0017148 negative regulation of translation [PMID:34347506]
experiment: EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:11816027]
note: Translational inhibitor and suppressor of proteasome-assembly defects; P-body component that inhibits translation, rescues proteasome base assembly defects and aggregation of regulatory particle subunits during stress when overexpressed; proposed to function to bridge the HOG and pheromone pathways with the cell wall integrity pathway in response to heat stress; interacts physically and genetically with splicing factor MSL1; large, highly-charge protein containing many disordered regions
codon start: 1
product: Nst1p
translation: MPPNSKSKRRKNKSKQHNKKNGNSDPEQSINPTQLVPRMEPELYHTESDYPTSRVIKRAPNGDVIVEPINTDDDKKERTANLTHNKDSMDSASSLAFTLDSHWESLSPEEKKTILRIEKEEVFNVIRNYQDDHSCSCSVCGRRHLAMDQEMERIYNTLYAMDKDKDPETNPIKFHLGIIKELQISKNQQQNDLSSTKGEVVKNFLSSSTVGSLKEEVLHFKQKQLSKQEQAHNETADNTSLLEENLNNIHINKTSSEISANFNSVSDEELQQKYSNFTKTFISSHPKIAEEYVQKMMMYPNIRALTDDLMNSNGQGFLNAIEDFVRDGQIQASKKDDSITEDEASSTDLTDPKEFTTMLHSGKPLTEDEYADLQRNIAERMTNAYDTASKKFKDVSQLEKELFTRFMSGRDKKSFRELIIQSFKNKFDGELGPSVLAATLSSCFSSQSKDTSLDTDSIYEDEDEEDYDDYSEYAEDSEEVSEYEGIEAVEKPEHDEKSNGIRETLHLSYDHDHKRQNHPHHHYHSTSTHSEDELSEEEYISDIELPHDPHKHFHRDDDILDGDEDEPEEEDENEGDDEEDTYDSGLDETDRLEEGRKLIQIAITKLLQSRIMASYHEKQADNNRLKLLQELEEEKRKKREKEEKKQKKREKEKEKKRLQQLAKEEEKRKREEEKERLKKELEEREMRRREAQRKKVEEAKRKKDEERKRRLEEQQRREEMQEKQRKQKEELKRKREEEKKRIREQKRLEQEKLQKEKEEEERQRLIAEDALRKQKLNEEQTSANILSAKPFTENGVGNPVSSQSHPNMTNYQEDNSCSINDEILKMVNSVAASKPVSPTGFNVHDLLLPSTNNQMPAMEQSHLPQPGNQNNHFGTTTIPNALDLATKSSLQTENNYLMNSQTLENTSLLMHNNSSPTKLLPNDFGLSSWGGLTNTMSINPTCKPPVIQTSEMESQAHKSSPQATMPSFGLPNGGTHRKSFTDELNTLTSMLSSSGFADTSLSSSGFPPSQRSVWNDQKSSFSGPSTAGNFNNSSIQSGMLLAPTLGSVESFPNRTSIWDSSTTPMMNKSELSGRNITSTAQDSPAFMASNIWSSNSQYNSPYLTSNVLQSPQISSGVDESHILDSIYNTYLAISPQDSLNPYIAIGTLFQNLVGLNLDYSTFINKLISMQGAYNCEFFTDNNGSITHVRFARQTPAGHSKGLLNQLFSGLNDPTATPFTSRPHTSTRASFPIASSTTQTS
SIO_010081: YNL091W
subclass of: SO_0000673
so part of: YNL091W
location: 452408..456130
location: region:452408-456130:1
so has part: feature:452408-456130:1:exon

NP_014308.1
type: Protein
SIO_000068: ncbiprotein

S000005035
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:452408-456130:1:exon

YNL090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RHO2
locus tag: YNL090W
so part of: sequence
location: <456565..>457143
location: region:456565-457143:1
so has part: feature:456565-457143:1:exon
subclass of: SO_0000010

855634
type: Gene
SIO_000068: ncbigene

position:456565:1
position: 456565
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457143:1
position: 457143
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:456565-457143:1:exon

YNL090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RHO2
locus tag: YNL090W
product: Rho family GTPase RHO2
transcript id: NM_001182928.3
SIO_010081: YNL090W
subclass of: SO_0000673
so part of: YNL090W
location: <456565..>457143
location: region:456565-457143:1
so has part: feature:456565-457143:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:456565-457143:1:exon

YNL090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RHO2
locus tag: YNL090W
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184|PMID:11591390]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:18417612]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly
codon start: 1
product: Rho family GTPase RHO2
translation: MSEKAVRRKLVIIGDGACGKTSLLYVFTLGKFPEQYHPTVFENYVTDCRVDGIKVSLTLWDTAGQEEYERLRPFSYSKADIILIGFAVDNFESLINARTKWADEALRYCPDAPIVLVGLKKDLRQEAHFKENATDEMVPIEDAKQVARAIGAKKYMECSALTGEGVDDVFEVATRTSLLMKKEPGANCCIIL
SIO_010081: YNL090W
subclass of: SO_0000673
so part of: YNL090W
location: 456565..457143
location: region:456565-457143:1
so has part: feature:456565-457143:1:exon

NP_014309.3
type: Protein
SIO_000068: ncbiprotein

S000005034
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:456565-457143:1:exon

YNL088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TOR3
alternative label: TRF3
gene: TOP2
locus tag: YNL088W
gene synonym: TOR3; TRF3
so part of: sequence
location: <457704..>461990
location: region:457704-461990:1
so has part: feature:457704-461990:1:exon
subclass of: SO_0000010

855636
type: Gene
SIO_000068: ncbigene

position:457704:1
position: 457704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461990:1
position: 461990
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:457704-461990:1:exon

YNL088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TOR3
alternative label: TRF3
gene: TOP2
locus tag: YNL088W
gene synonym: TOR3; TRF3
product: DNA topoisomerase 2
transcript id: NM_001182926.3
SIO_010081: YNL088W
subclass of: SO_0000673
so part of: YNL088W
location: <457704..>461990
location: region:457704-461990:1
so has part: feature:457704-461990:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:457704-461990:1:exon

YNL088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TOR3
alternative label: TRF3
gene: TOP2
locus tag: YNL088W
gene synonym: TOR3; TRF3
EC number: 5.6.2.2
experiment: EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:1315786]
experiment: EXISTENCE:direct assay:GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [PMID:6088500|PMID:6323017]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6088500|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:6088500]
experiment: EXISTENCE:direct assay:GO:0097047 DNA replication termination region [PMID:20797631]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:25430478]
experiment: EXISTENCE:genetic interaction:GO:0009303 rRNA transcription [PMID:2436053]
experiment: EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:2902925]
experiment: EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:31969709]
experiment: EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:2549254]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9199287]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2156624]
experiment: EXISTENCE:mutant phenotype:GO:0031055 chromatin remodeling at centromere [PMID:18701701]
experiment: EXISTENCE:mutant phenotype:GO:0097046 replication fork progression beyond termination site [PMID:20797631]
note: Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant
codon start: 1
product: DNA topoisomerase 2
translation: MSTEPVSASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLKSLEKKRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEENALKKSDGTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAEARGGNVPNKGSKTKGKGKRKLVDDEDYDPSKKNKKSTARKGKKIKLEDKNFERILLEQKLVTKSKAPTKIKKEKTPSVSETKTEEEENAPSSTSSSSIFDIKKEDKDEGELSKISNKFKKISTIFDKMGSTSATSKENTPEQDDVATKKNQTTAKKTAVKPKLAKKPVRKQQKVVELSGESDLEILDSYTDREDSNKDEDDAIPQRSRRQRSSRAASVPKKSYVETLELSDDSFIEDDEEENQGSDVSFNEED
SIO_010081: YNL088W
subclass of: SO_0000673
so part of: YNL088W
location: 457704..461990
location: region:457704-461990:1
so has part: feature:457704-461990:1:exon

NP_014311.3
type: Protein
SIO_000068: ncbiprotein

S000005032
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:457704-461990:1:exon

YNL087W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCB2
locus tag: YNL087W
so part of: sequence
location: <462411..>465947
location: region:462411-465947:1
so has part: feature:462411-465947:1:exon
subclass of: SO_0000010

855637
type: Gene
SIO_000068: ncbigene

position:462411:1
position: 462411
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:465947:1
position: 465947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462411-465947:1:exon

YNL087W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCB2
locus tag: YNL087W
product: tricalbin
transcript id: NM_001182925.1
SIO_010081: YNL087W
subclass of: SO_0000673
so part of: YNL087W
location: <462411..>465947
location: region:462411-465947:1
so has part: feature:462411-465947:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462411-465947:1:exon

YNL087W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCB2
locus tag: YNL087W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22250200]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22250200]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]
experiment: EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]
experiment: EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]
note: Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER, the cell periphery and is enriched in bud membranes; mRNA is targeted to the bud tip
codon start: 1
product: tricalbin
translation: MSPNSSKTRTDQISSMPGINEATKVESKNVVKDAVPIKSEVETNGTSIVREKQDPSYVGWKQVGGWEEKDELTSEDLLVDVNKDTFLGNLLPDKFYGDWYHEVAILIIAGLCSFVLGYFKFSLASVLIVMLTTGMLYRTSSKKYRESLRDLAQKEQTVEKITSDYESVEWLNTFLDKYWPIIEPSVSQQIVDGTNTALSENVAIPKFIKAIWLDQFTLGVKPPRIDAIKTFQNTKSDVVVMDVCLSFTPHDMSDLDAKQCRNYVNSNVVLKAKIFGMDIPVSVADIFFQVFVRFRFQLMTTLPLVETINIQLLEVPEVDFISRLLGNSVFNWEILAIPGLMRLIQKMAFKYLSPVLLPPFSLQLNIPQLLSKTGLPIGVLEIKVKNAHGLRKLVGMIKKTVDPYLTFELSGKIVGKTKVFKNSANPVWNESIYILLQSFTDPLTIAVYDKRETLSDKKMGTVIFNLNKLHANHYHKNEKVHFLRNSKPVGELTFDLRFFPTIEPKKLLNGDEEPLPDMNTGITKITIRELKGLDELSDKKFVFAELYVNAELVMTTKKEKRTAHLKWNSDYYSVVTDRRKTICRFVLKDQSGKVISSSVQPLNHLIDRTEVNKEWIPLRNGKGELKVTTYWRPVDIDLGLKSVGYTTPIGMLRVFINKAENLRNPDSLGKISPYAKVSVNGVARGRTNERIETLNPIWNQSIYVSVTSPLQKVSIDCFGIDTNGDDHNLGSLNIQTQNIYHKDNDDKYTIFIDNAPRTGNLIGKKGVKGTVTYYLSFYPVVPVLSLEEAKEVDEINEKKDKLEKQKSTLDDKNISKEEKERIKKEEFRLTEKYDMYSYKMKLDLDELLQYNAGVLGVTVLGGELPQPGLYVQTFFDSCGYAAITSAKNAIRTIKTGWSGDFMIKELEWSVTTFRVTKTKDANKAENFICEVNIPTIELVRNCYYKPSVLNLIGKKSAKLLVQVSWFPVTATELPQSDLITNSGDLKITAKSAENLIGVNKNGYSDPYVEFFLNEKSTSPFFKTAVQKKTLNPTWNESKTIEVSNRVNDYLTINVKDYESTNSNRSIGKAVVPLSTIDPESDTTFNIPLVGPKGEDGGVLHLEFEFEPRYTTNVVKREAGLGNFATKGLGTGIKAGSTVFALGTNVVSTGLGTIDKVKAGVFGGKKSTTTGDKKSEEKQ
SIO_010081: YNL087W
subclass of: SO_0000673
so part of: YNL087W
location: 462411..465947
location: region:462411-465947:1
so has part: feature:462411-465947:1:exon

NP_014312.1
type: Protein
SIO_000068: ncbiprotein

S000005031
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462411-465947:1:exon

YNL086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNN1
locus tag: YNL086W
so part of: sequence
location: <466334..>466642
location: region:466334-466642:1
so has part: feature:466334-466642:1:exon
subclass of: SO_0000010

855638
type: Gene
SIO_000068: ncbigene

position:466334:1
position: 466334
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:466642:1
position: 466642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466334-466642:1:exon

YNL086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNN1
locus tag: YNL086W
product: Snn1p
transcript id: NM_001182924.1
SIO_010081: YNL086W
subclass of: SO_0000673
so part of: YNL086W
location: <466334..>466642
location: region:466334-466642:1
so has part: feature:466334-466642:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466334-466642:1:exon

YNL086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNN1
locus tag: YNL086W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]
note: Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes
codon start: 1
product: Snn1p
translation: MAGDSISADGTGVHPVELSVYSVLSTDLDGLYQSINELRESQALLILMLRKVRDKLRREGQVLYDPEPFKPTMDKLADLSARVRILSQRYEELQGNARALNN
SIO_010081: YNL086W
subclass of: SO_0000673
so part of: YNL086W
location: 466334..466642
location: region:466334-466642:1
so has part: feature:466334-466642:1:exon

NP_014313.1
type: Protein
SIO_000068: ncbiprotein

S000005030
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466334-466642:1:exon

YNL085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MKT1
locus tag: YNL085W
so part of: sequence
location: <467131..>469623
location: region:467131-469623:1
so has part: feature:467131-469623:1:exon
subclass of: SO_0000010

855639
type: Gene
SIO_000068: ncbigene

position:467131:1
position: 467131
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:469623:1
position: 469623
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:467131-469623:1:exon

YNL085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MKT1
locus tag: YNL085W
product: Mkt1p
transcript id: NM_001182923.3
SIO_010081: YNL085W
subclass of: SO_0000673
so part of: YNL085W
location: <467131..>469623
location: region:467131-469623:1
so has part: feature:467131-469623:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:467131-469623:1:exon

YNL085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MKT1
locus tag: YNL085W
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:24970865]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:15082763]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:18617998]
note: Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains
codon start: 1
product: Mkt1p
translation: MAIKSLESFLFERGLVGSYAIEALNNCTLDIDVNHYVSRLLTNKREQYLDAIGGFPTSLKMYLESDLKIFKDFNITPIFVFNGGLTYNQLEASGHFTAASASASISSTTTSSSGTNATTRSNTESVLLQRSRGWTQWNNLISSNQNSYIDQPIQPQEPFRHNTTIDSKAYQNDLIAYFIEHGYMYQVAPYSSWFQLAYLLNSAYIDAIYGPTDCLMLDCVDRFILGMEFPNKEFRFIDRSRVMKDLGCTHEEFIDIAMAVGNDLQPTTLPPLQIYPVPQLFDIALEMVLNTGTNFYAYQLSTTLQNDSKENIQNYQRGISALRYMPVLKDTGKVELFVQEIVVSEEDSEKNNKDGKKSNLSSPSSASSSASPATTVTKNASEKLTYEKSSTKEVRKPRDIPNDVHDFIGQMLPHEYYFYRSIGLVTGKLFDAIVTGVYPEEPPLGGGSSTSYKKLVSKSVEIFKNKEINLLTQPINRYYQIKQIKQVKWYAANEPTTLTNRMSPSMFETINHLIVKTETSDEKEFSISEFITTINGSSNMAKDFISEKVIFPNSVPIESKLNSPFNLLSTNFLRLLVLLEFFTFDFKEKLLEPTRWGEVFLKLNELNIDSKYHESVIIFLVFLKCDVLKLDEEVQPPAPSALSQATLRSYPEESLYVLLITRVLTLFQVDQKPSNYHGPIDKKTLIFRDHLSFIKENLNELFEAVLISSLTSGEFNRLSLDNFGWARKIVRYLPFKLDSPNTIMAMMWEFFLQKYLHNGNAKNDALSLVATEFNTYKSTPNLDEQFVESHRFLLEISKVMQELNAAKLIDENVFKLFTKAVEFTTTALSS
SIO_010081: YNL085W
subclass of: SO_0000673
so part of: YNL085W
location: 467131..469623
location: region:467131-469623:1
so has part: feature:467131-469623:1:exon

NP_014314.3
type: Protein
SIO_000068: ncbiprotein

S000005029
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:467131-469623:1:exon

YNL084C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: END3
locus tag: YNL084C
so part of: sequence
location: complement(<470053..>471102)
location: region:470053-471102:-1
so has part: feature:470053-471102:-1:exon
subclass of: SO_0000010

855640
type: Gene
SIO_000068: ncbigene

position:470053:-1
position: 470053
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:471102:-1
position: 471102
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:470053-471102:-1:exon

YNL084C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: END3
locus tag: YNL084C
product: End3p
transcript id: NM_001182922.1
SIO_010081: YNL084C
subclass of: SO_0000673
so part of: YNL084C
location: complement(<470053..>471102)
location: region:470053-471102:-1
so has part: feature:470053-471102:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:470053-471102:-1:exon

YNL084C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: END3
locus tag: YNL084C
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990964 actin cytoskeleton-regulatory complex [PMID:10594004|PMID:17151356]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15944351]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10594004]
experiment: EXISTENCE:physical interaction:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356]
note: EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
codon start: 1
product: End3p
translation: MPKLEQFEIKKYWQIFSGLKPIENKVNHDQVLPILYNSKLDSSVLNKIWFLADIDDDDNLDFEEFVICMRLIFDMVNKNISSVPDELPDWLIPGSKVNLIKERKKRKQIENADLPPKKEIKVDWYMSPDDLNQYEKIYNSCAKLTDGTITFNELSTKLSTKFFNISKTDLNKVWSLINPQNLPSIDRDPTFYFIHCLRQRNDLGAEIPASLPNSLAEVCNKKQLSYDLRSSQPPTKRKEEANEVDNLRDNGQNSSSDSSGSNVLSNEDSIKQKYASLTDDQVANMREQLEGLLNYKKSEKTQGGSKLSKRINIRSITDDLDNIEQQVEVLENYLNNKRHELQALQAEIN
SIO_010081: YNL084C
subclass of: SO_0000673
so part of: YNL084C
location: complement(470053..471102)
location: region:470053-471102:-1
so has part: feature:470053-471102:-1:exon

NP_014315.1
type: Protein
SIO_000068: ncbiprotein

S000005028
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:470053-471102:-1:exon

YNL083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SAL1
locus tag: YNL083W
so part of: sequence
location: <471377..>472861
location: region:471377-472861:1
so has part: feature:471377-472861:1:exon
subclass of: SO_0000010

855641
type: Gene
SIO_000068: ncbigene

position:471377:1
position: 471377
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472861:1
position: 472861
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:471377-472861:1:exon

YNL083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SAL1
locus tag: YNL083W
product: Ca(2+)-binding ATP:ADP antiporter SAL1
transcript id: NM_001182921.1
SIO_010081: YNL083W
subclass of: SO_0000673
so part of: YNL083W
location: <471377..>472861
location: region:471377-472861:1
so has part: feature:471377-472861:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:471377-472861:1:exon

YNL083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SAL1
locus tag: YNL083W
experiment: EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:15238515]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0005471 ATP:ADP antiporter activity [PMID:18485069]
experiment: EXISTENCE:mutant phenotype:GO:0006839 mitochondrial transport [PMID:18485069]
experiment: EXISTENCE:mutant phenotype:GO:0015866 ADP transport [PMID:18485069]
experiment: EXISTENCE:mutant phenotype:GO:0015867 ATP transport [PMID:18485069]
note: ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
codon start: 1
product: Ca(2+)-binding ATP:ADP antiporter SAL1
translation: MLLKNCETDKQRDIRYACLFKELDVKGNGQVTLDNLISAFEKNDHPLKGNDEAIKMLFTAMDVNKDSVVDLSDFKKYASNAESQIWNGFQRIDLDHDGKIGINEINRYLSDLDNQSICNNELNHELSNEKMNKFSRFFEWAFPKRKANIALRGQASHKKNTDNDRSKKTTDSDLYVTYDQWRDFLLLVPRKQGSRLHTAYSYFYLFNEDVDLSSEGDVTLINDFIRGFGFFIAGGISGVISRTCTAPFDRLKVFLIARTDLSSILLNSKTDLLAKNPNADINKISSPLAKAVKSLYRQGGIKAFYVGNGLNVIKVFPESSIKFGSFEVTKKIMTKLEGCRDTKDLSKFSTYIAGGLAGMAAQFSVYPIDTLKFRVQCAPLDTKLKGNNLLFQTAKDMFREGGGQIILQRCHSRYSGHISLCCIRFGDFFCLKKMVYCQTGKDPEPTTRSGHSKQPGCTSNGCIQWNCRSFCCLSNQSFKNKTTSPRNICTSLCV
SIO_010081: YNL083W
subclass of: SO_0000673
so part of: YNL083W
location: 471377..472861
location: region:471377-472861:1
so has part: feature:471377-472861:1:exon

NP_014316.3
type: Protein
SIO_000068: ncbiprotein

S000005027
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:471377-472861:1:exon

YNL082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMS1
locus tag: YNL082W
so part of: sequence
location: <473391..>476012
location: region:473391-476012:1
so has part: feature:473391-476012:1:exon
subclass of: SO_0000010

855642
type: Gene
SIO_000068: ncbigene

position:473391:1
position: 473391
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:476012:1
position: 476012
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:473391-476012:1:exon

YNL082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMS1
locus tag: YNL082W
product: ATP-binding mismatch repair protein
transcript id: NM_001182920.3
SIO_010081: YNL082W
subclass of: SO_0000673
so part of: YNL082W
location: <473391..>476012
location: region:473391-476012:1
so has part: feature:473391-476012:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:473391-476012:1:exon

YNL082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMS1
locus tag: YNL082W
experiment: EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:9368761]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:11575920]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11575920]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11717305]
experiment: EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:9368761]
experiment: EXISTENCE:direct assay:GO:0032139 dinucleotide insertion or deletion binding [PMID:9368761]
experiment: EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10938116]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11717305]
experiment: EXISTENCE:physical interaction:GO:0032389 MutLalpha complex [PMID:10570173|PMID:11237696|PMID:8066446]
note: ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain; required for silencing at the silent mating-type loci and telomeres; similar to E. coli MutL
codon start: 1
product: ATP-binding mismatch repair protein
translation: MTQIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIEIIFKDYGLESIECSDNGDGIDPSNYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITTTSPPKADKLEYDMVGHITSKTTTSRNKGTTVLVSQLFHNLPVRQKEFSKTFKRQFTKCLTVIQGYAIINAAIKFSVWNITPKGKKNLILSTMRNSSMRKNISSVFGAGGMRGLEEVDLVLDLNPFKNRMLGKYTDDPDFLDLDYKIRVKGYISQNSFGCGRNSKDRQFIYVNKRPVEYSTLLKCCNEVYKTFNNVQFPAVFLNLELPMSLIDVNVTPDKRVILLHNERAVIDIFKTTLSDYYNRQELALPKRMCSQSEQQAQKRLKTEVFDDRSTTHESDNENYHTARSESNQSNHAHFNSTTGVIDKSNGTELTSVMDGNYTNVTDVIGSECEVSVDSSVVLDEGNSSTPTKKLPSIKTDSQNLSDLNLNNFSNPEFQNITSPDKARSLEKVVEEPVYFDIDGEKFQEKAVLSQADGLVFVDNECHEHTNDCCHQERRGSTDTEQDDEADSIYAEIEPVEINVRTPLKNSRKSISKDNYRSLSDGLTHRKFEDEILEYNLSTKNFKEISKNGKQMSSIISKRKSEAQENIIKNKDELEDFEQGEKYLTLTVSKNDFKKMEVVGQFNLGFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVFKSQKLIIPQPVELSVIDELVVLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKEDGGLRRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLSELDKPWNCPHGRPTMRHLMELRDWSSFSKDYEI
SIO_010081: YNL082W
subclass of: SO_0000673
so part of: YNL082W
location: 473391..476012
location: region:473391-476012:1
so has part: feature:473391-476012:1:exon

NP_014317.4
type: Protein
SIO_000068: ncbiprotein

S000005026
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:473391-476012:1:exon

YNL081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uS13m
gene: SWS2
locus tag: YNL081C
gene synonym: uS13m
so part of: sequence
location: complement(<476188..>476619)
location: region:476188-476619:-1
so has part: feature:476188-476619:-1:exon
subclass of: SO_0000010

855643
type: Gene
SIO_000068: ncbigene

position:476188:-1
position: 476188
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:476619:-1
position: 476619
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476188-476619:-1:exon

YNL081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uS13m
gene: SWS2
locus tag: YNL081C
gene synonym: uS13m
product: putative mitochondrial 37S ribosomal protein SWS2
transcript id: NM_001182919.3
SIO_010081: YNL081C
subclass of: SO_0000673
so part of: YNL081C
location: complement(<476188..>476619)
location: region:476188-476619:-1
so has part: feature:476188-476619:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476188-476619:-1:exon

YNL081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uS13m
gene: SWS2
locus tag: YNL081C
gene synonym: uS13m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081|PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2; localizes to peroxisomes in glucose-growing cells
codon start: 1
product: putative mitochondrial 37S ribosomal protein SWS2
translation: MVVHILGKGFKGKEVIKIALASKFYGIGKTTAEKICSKLGFYPWMRMHQLSEPQIMSIASELSTMTIEGDARAIVKDNIALKRKIGSYSGMRHTLHLPVRGQHTRNNAKTARKLNKIDRRGIHTFSQAKVQHNPSLWSCIFGK
SIO_010081: YNL081C
subclass of: SO_0000673
so part of: YNL081C
location: complement(476188..476619)
location: region:476188-476619:-1
so has part: feature:476188-476619:-1:exon

NP_014318.3
type: Protein
SIO_000068: ncbiprotein

S000005025
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476188-476619:-1:exon

YNL080C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EOS1
locus tag: YNL080C
so part of: sequence
location: complement(<476932..>478032)
location: region:476932-478032:-1
so has part: feature:476932-478032:-1:exon
subclass of: SO_0000010

855644
type: Gene
SIO_000068: ncbigene

position:476932:-1
position: 476932
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478032:-1
position: 478032
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476932-478032:-1:exon

YNL080C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EOS1
locus tag: YNL080C
product: Eos1p
transcript id: NM_001182918.1
SIO_010081: YNL080C
subclass of: SO_0000673
so part of: YNL080C
location: complement(<476932..>478032)
location: region:476932-478032:-1
so has part: feature:476932-478032:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476932-478032:-1:exon

YNL080C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EOS1
locus tag: YNL080C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17187761]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:17187761]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17187761]
note: Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
codon start: 1
product: Eos1p
translation: MTWILSTGMGPHEDKYAKHERATFKKTYSSMKTLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSITLYEPQSLRDAFTYFWQKLNSAYDNNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSLMVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQSYLTSDLRYIRNQEGEVQEDTNVPEETEDYEDGEDDADEDSHVVVADESTVDVPSNDSLSDNSDGGLFPVNRPSVSHSQSPKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLERILHEMHPPA
SIO_010081: YNL080C
subclass of: SO_0000673
so part of: YNL080C
location: complement(476932..478032)
location: region:476932-478032:-1
so has part: feature:476932-478032:-1:exon

NP_014319.1
type: Protein
SIO_000068: ncbiprotein

S000005024
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476932-478032:-1:exon

YNL079C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPM1
locus tag: YNL079C
so part of: sequence
location: complement(<478566..>479165)
location: region:478566-479165:-1
so has part: feature:478566-479165:-1:exon
subclass of: SO_0000010

855645
type: Gene
SIO_000068: ncbigene

position:478566:-1
position: 478566
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:479165:-1
position: 479165
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:478566-479165:-1:exon

YNL079C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPM1
locus tag: YNL079C
product: tropomyosin TPM1
transcript id: NM_001182917.1
SIO_010081: YNL079C
subclass of: SO_0000673
so part of: YNL079C
location: complement(<478566..>479165)
location: region:478566-479165:-1
so has part: feature:478566-479165:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:478566-479165:-1:exon

YNL079C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPM1
locus tag: YNL079C
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9864365]
experiment: EXISTENCE:direct assay:GO:0003786 actin lateral binding [PMID:11457840]
experiment: EXISTENCE:direct assay:GO:0005884 actin filament [PMID:7844152]
experiment: EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:2649250|PMID:9864365]
experiment: EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:9864365]
experiment: EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:2649250|PMID:7844152]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]
experiment: EXISTENCE:mutant phenotype:GO:0090527 actin filament reorganization [PMID:17237521]
note: Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication
codon start: 1
product: tropomyosin TPM1
translation: MDKIREKLSNLKLEAESWQEKYEELKEKNKDLEQENVEKENQIKSLTVKNQQLEDEIEKLEAGLSDSKQTEQDNVEKENQIKSLTVKNHQLEEEIEKLEAELAESKQLSEDSHHLQSNNDNFSKKNQQLEEDLEESDTKLKETTEKLRESDLKADQLERRVAALEEQREEWERKNEELTVKYEDAKKELDEIAASLENL
SIO_010081: YNL079C
subclass of: SO_0000673
so part of: YNL079C
location: complement(478566..479165)
location: region:478566-479165:-1
so has part: feature:478566-479165:-1:exon

NP_014320.1
type: Protein
SIO_000068: ncbiprotein

S000005023
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:478566-479165:-1:exon

YNL078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: JIP1
gene: NIS1
locus tag: YNL078W
gene synonym: JIP1
so part of: sequence
location: <479768..>480991
location: region:479768-480991:1
so has part: feature:479768-480991:1:exon
subclass of: SO_0000010

855646
type: Gene
SIO_000068: ncbigene

position:479768:1
position: 479768
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:480991:1
position: 480991
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:479768-480991:1:exon

YNL078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: JIP1
gene: NIS1
locus tag: YNL078W
gene synonym: JIP1
product: Nis1p
transcript id: NM_001182916.3
SIO_010081: YNL078W
subclass of: SO_0000673
so part of: YNL078W
location: <479768..>480991
location: region:479768-480991:1
so has part: feature:479768-480991:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:479768-480991:1:exon

YNL078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: JIP1
gene: NIS1
locus tag: YNL078W
gene synonym: JIP1
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:25416945|PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11817649]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11817649|PMID:27385335]
experiment: EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]
experiment: EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:30341817]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]
experiment: EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:29074565]
experiment: EXISTENCE:physical interaction:GO:0140014 mitotic nuclear division [PMID:11817649]
note: Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevents Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants
codon start: 1
product: Nis1p
translation: METYETSIGTQSYPPTLFPPPLGTGGFTTSGYIHALVDSTSNSNSNSNTNSNTNSNTNSNSDTKIPIVQISDDSHITHDSFKPYMEYHDASHLRNRNISKADQVESTEVMEQFTQWSNYKMRSRSPTINAKPIRHTSQRRTDFTSKNELSKFSKNHNFIFHKGFLKRQHSIRREDRQAKVRSRFRSKKELTSVLNYIELEQMDIANVLASQPVNLHAIRNLTSRDPAVTPIPFLRSQMYATSSRPPYLRNRSISRKLPKSQPGSLPTTMPATATKTIKQNSTTPTTRSVYNKNVGRSNTSPSVLYHPKRRGKLNTKSHARKEQLLLELWREYLMLVITQRTQLRLTLLCSPGSASNESSVCSSNASDLDMSLLSTPSSLFQMAGETKSNPIIIPDSQDDSILSSDPF
SIO_010081: YNL078W
subclass of: SO_0000673
so part of: YNL078W
location: 479768..480991
location: region:479768-480991:1
so has part: feature:479768-480991:1:exon

NP_014321.3
type: Protein
SIO_000068: ncbiprotein

S000005022
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:479768-480991:1:exon

YNL077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APJ1
locus tag: YNL077W
so part of: sequence
location: <481391..>482977
location: region:481391-482977:1
so has part: feature:481391-482977:1:exon
subclass of: SO_0000010

855647
type: Gene
SIO_000068: ncbigene

position:481391:1
position: 481391
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482977:1
position: 482977
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:481391-482977:1:exon

YNL077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APJ1
locus tag: YNL077W
product: Apj1p
transcript id: NM_001182915.1
SIO_010081: YNL077W
subclass of: SO_0000673
so part of: YNL077W
location: <481391..>482977
location: region:481391-482977:1
so has part: feature:481391-482977:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:481391-482977:1:exon

YNL077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APJ1
locus tag: YNL077W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23329686]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0042405 nuclear inclusion body [PMID:32492414]
experiment: EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:23329686]
experiment: EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32492414]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11923285]
note: Hsp40 chaperone with a role in SUMO-mediated protein degradation; works in concert with Hsp70 and Hsp110 (Sse1p) to promote disaggregation of intranuclear protein inclusions; competes with Hsp104 in disaggregation, supporting turnover instead of refolding; member of DnaJ-like family, conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; forms nuclear foci upon DNA replication stress
codon start: 1
product: Apj1p
translation: MQQNTSLYDSLNVTAAASTSEIKKAYRNAALKYHPDKNNHTEESKRKFQEICQAYEILKDNRLRALYDQYGTTDEVLIQEQQAQAQRQQAGPFSSSSNFDTEAMSFPDLSPGDLFAQFFNSSATPSSNGSKSSFNFSFNNSSTPSFSFVNGSGVNNLYSSSAKYNSNDEDHHLDRGPDIKHNLKCTLKELYMGKTAKLGLNRTRICSVCDGHGGLKKCTCKTCKGQGIQTQTRRMGPLVQSWSQTCADCGGAGVFVKNKDICQQCQGLGFIKERKILQVTVQPGSCHNQLIVLTGEGDEVISTKGGGHEKVIPGDVVITILRLKDPNFQVINYSNLICKKCKIDFMTSLCGGVVYIEGHPSGKLIKLDIIPGEILKPGCFKTVEDMGMPKFINGVRSGFGHLYVKFDVTYPERLEPENAKKIQNILANDKYIKAERSTMETADSDCYCDLEKSYDSVEEHVLSSFEAPNLNNEVIEDDDLGDLINERDSRKRNNRRFDESNINNNNETKRNKYSSPVSGFYDHDINGY
SIO_010081: YNL077W
subclass of: SO_0000673
so part of: YNL077W
location: 481391..482977
location: region:481391-482977:1
so has part: feature:481391-482977:1:exon

NP_014322.1
type: Protein
SIO_000068: ncbiprotein

S000005021
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:481391-482977:1:exon

YNL076W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LYS80
gene: MKS1
locus tag: YNL076W
gene synonym: LYS80
so part of: sequence
location: <483556..>485310
location: region:483556-485310:1
so has part: feature:483556-485310:1:exon
subclass of: SO_0000010

855648
type: Gene
SIO_000068: ncbigene

position:483556:1
position: 483556
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485310:1
position: 485310
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483556-485310:1:exon

YNL076W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LYS80
gene: MKS1
locus tag: YNL076W
gene synonym: LYS80
product: Mks1p
transcript id: NM_001182914.1
SIO_010081: YNL076W
subclass of: SO_0000673
so part of: YNL076W
location: <483556..>485310
location: region:483556-485310:1
so has part: feature:483556-485310:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483556-485310:1:exon

YNL076W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LYS80
gene: MKS1
locus tag: YNL076W
gene synonym: LYS80
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10511541]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]
experiment: EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:10511541]
experiment: EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]
experiment: EXISTENCE:physical interaction:GO:0031930 mitochondria-nucleus signaling pathway [PMID:14536080]
note: Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
codon start: 1
product: Mks1p
translation: MSREAFDVPNIGTNKFLKVTPNLFTPERLNLFDDVELYLTLIKASKCVEQGERLHNISWRILNKAVLKEHNINRSKKRDGVKNIYYVLNPNNKQPIKPKQAAVKQPPLQKANLPPTTAKQNVLTRPMTSPAIAQGAHDRSLDNPNSTNNDVKNDVAPNRQFSKSTTSGLFSNFADKYQKMKNVNHVANKEEPQTIITGFDTSTVITKKPLQSRRSRSPFQHIGDMNMNCIDNETSKSTSPTLENMGSRKSSFPQKESLFGRPRSYKNDQNGQLSLSKTSSRKGKNKIFFSSEDEDSDWDSVSNDSEFYADEDDEEYDDYNEEEADQYYRRQWDKLLFAKNQQNLDSTKSSVSSANTINSNTSHDPVRKSLLSGLFLSEANSNSNNHNTAHSEYASKHVSPTPQSSHSNIGPQPQQNPPSANGIKQQKPSLKTSNVTALASLSPPQPSNNERLSMDIQKDFKTDNESNHLYESNAPLTAQTILPTALSTHMFLPNNIHQQRMAIATGSNTRHRFSRRQSMDIPSKNRNTGFLKTRMEISEEEKMVRTISRLDNTSIANSNGNGNDDTSNQRTEALGRKTSNGGRI
SIO_010081: YNL076W
subclass of: SO_0000673
so part of: YNL076W
location: 483556..485310
location: region:483556-485310:1
so has part: feature:483556-485310:1:exon

NP_014323.1
type: Protein
SIO_000068: ncbiprotein

S000005020
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483556-485310:1:exon

YNL075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMP4
locus tag: YNL075W
so part of: sequence
location: <485607..>486479
location: region:485607-486479:1
so has part: feature:485607-486479:1:exon
subclass of: SO_0000010

855649
type: Gene
SIO_000068: ncbigene

position:485607:1
position: 485607
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486479:1
position: 486479
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485607-486479:1:exon

YNL075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMP4
locus tag: YNL075W
product: snoRNA-binding rRNA-processing protein IMP4
transcript id: NM_001182913.3
SIO_010081: YNL075W
subclass of: SO_0000673
so part of: YNL075W
location: <485607..>486479
location: region:485607-486479:1
so has part: feature:485607-486479:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485607-486479:1:exon

YNL075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMP4
locus tag: YNL075W
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:23980203]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:15489263]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309|PMID:12242301]
experiment: EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:23980203]
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17803460]
note: Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
codon start: 1
product: snoRNA-binding rRNA-processing protein IMP4
translation: MLRRQARERREYLYRKAQELQDSQLQQKRQIIKQALAQGKPLPKELAEDESLQKDFRYDQSLKESEEADDLQVDDEYAATSGIMDPRIIVTTSRDPSTRLSQFAKEIKLLFPNAVRLNRGNYVMPNLVDACKKSGTTDLVVLHEHRGVPTSLTISHFPHGPTAQFSLHNVVMRHDIINAGNQSEVNPHLIFDNFTTALGKRVVCILKHLFNAGPKKDSERVITFANRGDFISVRQHVYVRTREGVEIAEVGPRFEMRLFELRLGTLENKDADVEWQLRRFIRTANKKDYL
SIO_010081: YNL075W
subclass of: SO_0000673
so part of: YNL075W
location: 485607..486479
location: region:485607-486479:1
so has part: feature:485607-486479:1:exon

NP_014324.3
type: Protein
SIO_000068: ncbiprotein

S000005019
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485607-486479:1:exon

YNL074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YMK1
gene: MLF3
locus tag: YNL074C
gene synonym: YMK1
so part of: sequence
location: complement(<486766..>488124)
location: region:486766-488124:-1
so has part: feature:486766-488124:-1:exon
subclass of: SO_0000010

855650
type: Gene
SIO_000068: ncbigene

position:486766:-1
position: 486766
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:488124:-1
position: 488124
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486766-488124:-1:exon

YNL074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YMK1
gene: MLF3
locus tag: YNL074C
gene synonym: YMK1
product: Mlf3p
transcript id: NM_001182912.3
SIO_010081: YNL074C
subclass of: SO_0000673
so part of: YNL074C
location: complement(<486766..>488124)
location: region:486766-488124:-1
so has part: feature:486766-488124:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486766-488124:-1:exon

YNL074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YMK1
gene: MLF3
locus tag: YNL074C
gene synonym: YMK1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:16816427]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:16816427]
note: Serine-rich hypothetical protein; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication
codon start: 1
product: Mlf3p
translation: MCVYKSNSNNSNPSFIFERTVQEASSNDLFLQPPVSASNTSHSSRSNSFYNLQTISPIPISGSEVRTPSLRKNSNNVSSPLDNVIPTSRSASNSTTSSLAHQEYILNPICNMQNHHHRRRTLENSVAPALDASCSIVNDENTDLSDVDMVYSRRPSSAVSLNMALLARTNSATLPSSESSPASPDLKLSRSHSHSAATRPTLNNINNTGMTTTTSNGEPNSRILRFYSYVDMLNDEKLAQANNTPTSRPPMKSQAYSCPFILKRSPPQAYSSSSATTTFSNPFIKTTELPATSPYVSPQQSARQYSNNANNNAKSPKNRSSSILFQRQSILSNVDPVANMHKNPKFQIESSDSEEEDLTMDMLDPSFPLSSSLRSSANLASNPELATQTPLSTSSSYTAIGKPMPLSTDPSYVSSSNTLSSEHELRVEKVSEVLKKKVSNGGFSTEFNSCDT
SIO_010081: YNL074C
subclass of: SO_0000673
so part of: YNL074C
location: complement(486766..488124)
location: region:486766-488124:-1
so has part: feature:486766-488124:-1:exon

NP_014325.3
type: Protein
SIO_000068: ncbiprotein

S000005018
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486766-488124:-1:exon

YNL073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSK1
locus tag: YNL073W
so part of: sequence
location: <488386..>490116
location: region:488386-490116:1
so has part: feature:488386-490116:1:exon
subclass of: SO_0000010

855651
type: Gene
SIO_000068: ncbigene

position:488386:1
position: 488386
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490116:1
position: 490116
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488386-490116:1:exon

YNL073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSK1
locus tag: YNL073W
product: lysine--tRNA ligase MSK1
transcript id: NM_001182911.1
SIO_010081: YNL073W
subclass of: SO_0000673
so part of: YNL073W
location: <488386..>490116
location: region:488386-490116:1
so has part: feature:488386-490116:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488386-490116:1:exon

YNL073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSK1
locus tag: YNL073W
EC number: 6.1.1.6
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2016746|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0008033 tRNA processing [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0004824 lysine-tRNA ligase activity [PMID:2016746]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0070154 mitochondrial lysyl-tRNA aminoacylation [PMID:2016746]
note: Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
codon start: 1
product: lysine--tRNA ligase MSK1
translation: MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATRRNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNFLKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVDYQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVDDVNRQ
SIO_010081: YNL073W
subclass of: SO_0000673
so part of: YNL073W
location: 488386..490116
location: region:488386-490116:1
so has part: feature:488386-490116:1:exon

NP_014326.1
type: Protein
SIO_000068: ncbiprotein

S000005017
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488386-490116:1:exon

YNL072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RNH35
gene: RNH201
locus tag: YNL072W
gene synonym: RNH35
so part of: sequence
location: <490317..>491240
location: region:490317-491240:1
so has part: feature:490317-491240:1:exon
subclass of: SO_0000010

855652
type: Gene
SIO_000068: ncbigene

position:490317:1
position: 490317
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:491240:1
position: 491240
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490317-491240:1:exon

YNL072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RNH35
gene: RNH201
locus tag: YNL072W
gene synonym: RNH35
product: ribonuclease H2 catalytic subunit RNH201
transcript id: NM_001182910.1
SIO_010081: YNL072W
subclass of: SO_0000673
so part of: YNL072W
location: <490317..>491240
location: region:490317-491240:1
so has part: feature:490317-491240:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490317-491240:1:exon

YNL072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RNH35
gene: RNH201
locus tag: YNL072W
gene synonym: RNH35
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11029655]
experiment: EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]
experiment: EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]
experiment: EXISTENCE:genetic interaction:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]
experiment: EXISTENCE:mutant phenotype:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]
note: Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
codon start: 1
product: ribonuclease H2 catalytic subunit RNH201
translation: MVPPTVEASLESPYTKSYFSPVPSALLEQNDSPIIMGIDEAGRGPVLGPMVYAVAYSTQKYQDETIIPNYEFDDSKKLTDPIRRMLFSKIYQDNEELTQIGYATTCITPLDISRGMSKFPPTRNYNLNEQAHDVTMALIDGVIKQNVKLSHVYVDTVGPPASYQKKLEQRFPGVKFTVAKKADSLYCMVSVASVVAKVTRDILVESLKRDPDEILGSGYPSDPKTVAWLKRNQTSLMGWPANMVRFSWQTCQTLLDDASKNSIPIKWEEQYMDSRKNAAQKTKQLQLQMVAKPVRRKRLRTLDNWYR
SIO_010081: YNL072W
subclass of: SO_0000673
so part of: YNL072W
location: 490317..491240
location: region:490317-491240:1
so has part: feature:490317-491240:1:exon

NP_014327.1
type: Protein
SIO_000068: ncbiprotein

S000005016
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490317-491240:1:exon

YNL071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ODP2
alternative label: PDA2
gene: LAT1
locus tag: YNL071W
gene synonym: ODP2; PDA2
so part of: sequence
location: <491523..>492971
location: region:491523-492971:1
so has part: feature:491523-492971:1:exon
subclass of: SO_0000010

855653
type: Gene
SIO_000068: ncbigene

position:491523:1
position: 491523
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:492971:1
position: 492971
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491523-492971:1:exon

YNL071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ODP2
alternative label: PDA2
gene: LAT1
locus tag: YNL071W
gene synonym: ODP2; PDA2
product: dihydrolipoyllysine-residue acetyltransferase
transcript id: NM_001182909.3
SIO_010081: YNL071W
subclass of: SO_0000673
so part of: YNL071W
location: <491523..>492971
location: region:491523-492971:1
so has part: feature:491523-492971:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491523-492971:1:exon

YNL071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ODP2
alternative label: PDA2
gene: LAT1
locus tag: YNL071W
gene synonym: ODP2; PDA2
EC number: 2.3.1.12
experiment: EXISTENCE:direct assay:GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity [PMID:2271545]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:24769239|PMID:11914276|P MID:16823961]
experiment: EXISTENCE:direct assay:GO:0005967 mitochondrial pyruvate dehydrogenase complex [PMID:2007123|PMID:9038189]
experiment: EXISTENCE:direct assay:GO:0006086 acetyl-CoA biosynthetic process from pyruvate [PMID:7947791]
note: Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; metabolic longevity factor required for calorie restriction-mediated life span extension
codon start: 1
product: dihydrolipoyllysine-residue acetyltransferase
translation: MSAFVRVVPRISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEKKQEAPAEETKTSAPEAKKSDVAAPQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL
SIO_010081: YNL071W
subclass of: SO_0000673
so part of: YNL071W
location: 491523..492971
location: region:491523-492971:1
so has part: feature:491523-492971:1:exon

NP_014328.3
type: Protein
SIO_000068: ncbiprotein

S000005015
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491523-492971:1:exon

YNL070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MOM7
alternative label: YOK22
gene: TOM7
locus tag: YNL070W
gene synonym: MOM7; YOK22
so part of: sequence
location: <493366..>493548
location: region:493366-493548:1
so has part: feature:493366-493548:1:exon
subclass of: SO_0000010

855654
type: Gene
SIO_000068: ncbigene

position:493366:1
position: 493366
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:493548:1
position: 493548
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:493366-493548:1:exon

YNL070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MOM7
alternative label: YOK22
gene: TOM7
locus tag: YNL070W
gene synonym: MOM7; YOK22
product: Tom7p
transcript id: NM_001182908.1
SIO_010081: YNL070W
subclass of: SO_0000673
so part of: YNL070W
location: <493366..>493548
location: region:493366-493548:1
so has part: feature:493366-493548:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:493366-493548:1:exon

YNL070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MOM7
alternative label: YOK22
gene: TOM7
locus tag: YNL070W
gene synonym: MOM7; YOK22
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]
experiment: EXISTENCE:mutant phenotype:GO:0005742 mitochondrial outer membrane translocase complex [PMID:8641278]
experiment: EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:8641278]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8641278]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:8641278]
note: Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
codon start: 1
product: Tom7p
translation: MSFLPSFILSDESKERISKILTLTHNVAHYGWIPFVLYLGWAHTSNRPNFLNLLSPLPSV
SIO_010081: YNL070W
subclass of: SO_0000673
so part of: YNL070W
location: 493366..493548
location: region:493366-493548:1
so has part: feature:493366-493548:1:exon

NP_014329.1
type: Protein
SIO_000068: ncbiprotein

S000005014
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:493366-493548:1:exon

YNL069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RP23
gene: RPL16B
locus tag: YNL069C
gene synonym: RP23
so part of: sequence
location: complement(<493956..>495001)
location: region:493956-495001:-1
so has part: feature:493956-495001:-1:exon
subclass of: SO_0000010

855655
type: Gene
SIO_000068: ncbigene

position:493956:-1
position: 493956
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:495001:-1
position: 495001
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:493956-495001:-1:exon

YNL069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RP23
gene: RPL16B
locus tag: YNL069C
gene synonym: RP23
product: ribosomal 60S subunit protein L16B
transcript id: NM_001182907.1
SIO_010081: YNL069C
subclass of: SO_0000673
so part of: YNL069C
location: complement(join(<493956..494524,494974..>495001))
location: region:493956-495001:-1
so has part: feature:494974-495001:-1:exon
so has part: feature:493956-494524:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494974-495001:-1:exon

position:494974:-1
position: 494974
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:493956-494524:-1:exon

position:494524:-1
position: 494524
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RP23
gene: RPL16B
locus tag: YNL069C
gene synonym: RP23
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:27374275]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:27374275]
note: Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L16B
translation: MSQPVVVIDAKDHLLGRLASTIAKQVLNGQKIVVVRAEALNISGEFFRNKLKYHDFLRKATAFNKTRGPFHFRAPSRILYKAIRGMVSHKTARGKAALERLKIFEGIPPPYDKKKRVVVPQALRVLRLKPGRKYTTLGKLSTSVGWKYEDVVAKLEDKRKVRSAEYYAKKRAFTKKVSSASAAASESDVAKQLASFGY
SIO_010081: YNL069C
subclass of: SO_0000673
so part of: YNL069C
location: complement(join(493956..494524,494974..495001))
location: region:493956-495001:-1
so has part: feature:494974-495001:-1:exon
so has part: feature:493956-494524:-1:exon

NP_014330.1
type: Protein
SIO_000068: ncbiprotein

S000005013
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494974-495001:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:493956-494524:-1:exon

YNL068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FKH2
locus tag: YNL068C
so part of: sequence
location: complement(<495701..>498289)
location: region:495701-498289:-1
so has part: feature:495701-498289:-1:exon
subclass of: SO_0000010

855656
type: Gene
SIO_000068: ncbigene

position:495701:-1
position: 495701
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498289:-1
position: 498289
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:495701-498289:-1:exon

YNL068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FKH2
locus tag: YNL068C
product: forkhead family transcription factor FKH2
transcript id: NM_001182906.3
SIO_010081: YNL068C
subclass of: SO_0000673
so part of: YNL068C
location: complement(<495701..>498289)
location: region:495701-498289:-1
so has part: feature:495701-498289:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:495701-498289:-1:exon

YNL068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FKH2
locus tag: YNL068C
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24504085]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:22265405|PMID:24504085]
experiment: EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:15509804|PMID:10959837]
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:10899128]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10899128|PMID:20847055|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:24504085|PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10899128|PMID:10959837|PMID:12711672|PMID:15509804]
experiment: EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:17283050]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]
experiment: EXISTENCE:genetic interaction:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]
experiment: EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10959837|PMID:15509804]
experiment: EXISTENCE:genetic interaction:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:17898805]
experiment: EXISTENCE:genetic interaction:GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle [PMID:11562353|PMID:15509804|PMID:10747051|PMID:10894548|P MID:10959837]
experiment: EXISTENCE:genetic interaction:GO:0090419 negative regulation of transcription involved in G2/M transition of mitotic cell cycle [PMID:10894549]
experiment: EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:10747051|PMID:10894548]
experiment: EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:15509804]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17283050]
experiment: EXISTENCE:mutant phenotype:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:22265405]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]
experiment: EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]
experiment: EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12711672|PMID:10899128|PMID:15509804]
experiment: EXISTENCE:mutant phenotype:GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle [PMID:10959837|PMID:10899128]
experiment: EXISTENCE:mutant phenotype:GO:1903468 positive regulation of DNA replication initiation [PMID:26728715]
experiment: EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:10894548]
note: Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia
codon start: 1
product: forkhead family transcription factor FKH2
translation: MSSSNFNEMNELNMTQTNYGSTKYTAQHHQGVINAIISSLTAPDQPTTVSLQYSNDKNMATEIQAYAKLSGPNWTYYVKDLEVSIGRNTDPLNSALQENSDGVKNSYRVNIDLGPAKVVSRKHAIIKYNMNIGGWELHILGRNGAKVNFQRTHNGPNNPPIRLSSGTLLDIGGTQMMFILPDSDPVVAPICIEHLMPNLINMFGLEGNNNPLLRDIIKQSNYAKQRQLTSNQQIKGFKLYGSGGNAPFGSGANLGPSEQGIFNNNNNSKNKNGYFTSINPNYTASTTTSNTINPQAASPQGPPNTIIAANFVDSYKSSNAYPQALDFTSDLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYRFAKSGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWRISESYQQEFLNKWNTGKVGKIRRGSSVARQLQLHMAKFNSLPMEMDYRLSLNMAQPPKRQLQSHNVLEPSNNNIIEGFVQHVPSKGNLPASQQSQPPVSHQNQSQQPPPQEQRQEIQFTFADTQNRNIALARPIKTPQLQAPNSNANLNQNNMKEYKESLHPPAISISQMNRQSPNNALVSFTNACANSKIINNISDSADKSTNNNGGTKMNLPAISTSSLDENGNLEPTTTTSSGNSNSVPQTGTTTSSLAANSLRLSQPYDTLLRSPTKAFHITAMEAYTPERGSANRARSPLHSNSNNTNNNGANNSNLQTSGMENKQTGLVLDSNVLKSMESNNDNRRLTPSTSKSQNVKSSPGVWNLLQFSSTNNTPAADSGGNKRGFSINPDIKAKENENATSEKDSDSNSNDLETKDINSSPLKNQGGSTANAKELILDTDGAKISIINN
SIO_010081: YNL068C
subclass of: SO_0000673
so part of: YNL068C
location: complement(495701..498289)
location: region:495701-498289:-1
so has part: feature:495701-498289:-1:exon

NP_014331.3
type: Protein
SIO_000068: ncbiprotein

S000005012
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:495701-498289:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1420; Autonomously Replicating Sequence
so part of: sequence
location: 498970..499154
location: region:498970-499154:1
so has part: feature:498970-499154:1:region

S000118388
type: SGD
SIO_000068: sgd

position:498970:1
position: 498970
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:499154:1
position: 499154
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498970-499154:1:region

YNL067W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNL067W-A
locus tag: YNL067W-B
gene synonym: YNL067W-A
so part of: sequence
location: <499417..>499557
location: region:499417-499557:1
so has part: feature:499417-499557:1:exon
subclass of: SO_0000010

1466514
type: Gene
SIO_000068: ncbigene

position:499417:1
position: 499417
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499557:1
position: 499557
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499417-499557:1:exon

YNL067W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNL067W-A
locus tag: YNL067W-B
gene synonym: YNL067W-A
product: uncharacterized protein
transcript id: NM_001184639.3
SIO_010081: YNL067W-B
subclass of: SO_0000673
so part of: YNL067W-B
location: <499417..>499557
location: region:499417-499557:1
so has part: feature:499417-499557:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499417-499557:1:exon

YNL067W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNL067W-A
locus tag: YNL067W-B
gene synonym: YNL067W-A
codon start: 1
product: uncharacterized protein
translation: MCKLMWCTGVVSKTALLTGNFFFSSSEFFFKATHRKSENYLNGRQT
SIO_010081: YNL067W-B
subclass of: SO_0000673
so part of: YNL067W-B
location: 499417..499557
location: region:499417-499557:1
so has part: feature:499417-499557:1:exon

NP_878156.3
type: Protein
SIO_000068: ncbiprotein

S000028810
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499417-499557:1:exon

YNL067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL9B
locus tag: YNL067W
so part of: sequence
location: <499681..>500256
location: region:499681-500256:1
so has part: feature:499681-500256:1:exon
subclass of: SO_0000010

855658
type: Gene
SIO_000068: ncbigene

position:499681:1
position: 499681
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:500256:1
position: 500256
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499681-500256:1:exon

YNL067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL9B
locus tag: YNL067W
product: ribosomal 60S subunit protein L9B
transcript id: NM_001182905.1
SIO_010081: YNL067W
subclass of: SO_0000673
so part of: YNL067W
location: <499681..>500256
location: region:499681-500256:1
so has part: feature:499681-500256:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499681-500256:1:exon

YNL067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL9B
locus tag: YNL067W
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
note: Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication
codon start: 1
product: ribosomal 60S subunit protein L9B
translation: MKYIQTEQQIEIPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGDRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFIVEDM
SIO_010081: YNL067W
subclass of: SO_0000673
so part of: YNL067W
location: 499681..500256
location: region:499681-500256:1
so has part: feature:499681-500256:1:exon

NP_014332.1
type: Protein
SIO_000068: ncbiprotein

S000005011
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499681-500256:1:exon

YNL066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCW3
gene: SUN4
locus tag: YNL066W
gene synonym: SCW3
so part of: sequence
location: <501515..>502777
location: region:501515-502777:1
so has part: feature:501515-502777:1:exon
subclass of: SO_0000010

855659
type: Gene
SIO_000068: ncbigene

position:501515:1
position: 501515
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502777:1
position: 502777
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501515-502777:1:exon

YNL066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCW3
gene: SUN4
locus tag: YNL066W
gene synonym: SCW3
product: putative glucosidase SUN4
transcript id: NM_001182904.1
SIO_010081: YNL066W
subclass of: SO_0000673
so part of: YNL066W
location: <501515..>502777
location: region:501515-502777:1
so has part: feature:501515-502777:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501515-502777:1:exon

YNL066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCW3
gene: SUN4
locus tag: YNL066W
gene synonym: SCW3
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11958935]
note: Cell wall protein related to glucanases localized in birth scars; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication
codon start: 1
product: putative glucosidase SUN4
translation: MKLSATTLTAASLIGYSTIVSALPYAADIDTGCTTTAHGSHQHKRAVAVTYVYETVTVDKNGQTVTPTSTEASSTVASTTTLISESSVTKSSSKVASSSESTEQIATTSSSAQTTLTSSETSTSESSVPISTSGSASTSSAASSATGSIYGDLADFSGPYEKFEDGTIPCGQFPSGQGVIPISWLDEGGWSGVENTDTSTGGSCKEGSYCSYACQPGMSKTQWPSDQPSDGRSIGGLLCKDGYLYRSNTDTDYLCEWGVDAAYVVSELSNDVAICRTDYPGTENMVIPTYVQAGDSLPLTVVDQDTYYTWQGLKTSAQYYVNNAGISVEDACVWGSSSSGVGNWAPLNFGAGSSDGVAYLSLIPNPNNGNALNFNVKIVAADDSSTVNGECIYENGSFSGGSDGCTVSVTAGKAKFVLYN
SIO_010081: YNL066W
subclass of: SO_0000673
so part of: YNL066W
location: 501515..502777
location: region:501515-502777:1
so has part: feature:501515-502777:1:exon

NP_014333.1
type: Protein
SIO_000068: ncbiprotein

S000005010
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501515-502777:1:exon

YNL065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AQR1
locus tag: YNL065W
so part of: sequence
location: <503724..>505484
location: region:503724-505484:1
so has part: feature:503724-505484:1:exon
subclass of: SO_0000010

855660
type: Gene
SIO_000068: ncbigene

position:503724:1
position: 503724
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:505484:1
position: 505484
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503724-505484:1:exon

YNL065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AQR1
locus tag: YNL065W
product: Aqr1p
transcript id: NM_001182903.3
SIO_010081: YNL065W
subclass of: SO_0000673
so part of: YNL065W
location: <503724..>505484
location: region:503724-505484:1
so has part: feature:503724-505484:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:503724-505484:1:exon

YNL065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AQR1
locus tag: YNL065W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11922628|PMID:22842922|PMID:34887841]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0032973 amino acid export across plasma membrane [PMID:15590823]
experiment: EXISTENCE:mutant phenotype:GO:0008028 monocarboxylic acid transmembrane transporter activity [PMID:11922628]
experiment: EXISTENCE:mutant phenotype:GO:0015565 threonine efflux transmembrane transporter activity [PMID:34887841]
experiment: EXISTENCE:mutant phenotype:GO:0015718 monocarboxylic acid transport [PMID:11922628]
experiment: EXISTENCE:mutant phenotype:GO:0032973 amino acid export across plasma membrane [PMID:15590823|PMID:34887841]
experiment: EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:11922628]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11922628]
note: Plasma membrane transporter of the major facilitator superfamily; involved in the excretion of excess amino acids; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; AQR1 has a paralog, QDR1, that arose from the whole genome duplication
codon start: 1
product: Aqr1p
translation: MSRSNSIYTEDIEMYPTHNEQHLTREYTKPDGQTKSEKLNFEGAYINSHGTLSKTTTREIEGDLDSETSSHSSDDKVDPTQQITAETKAPYTLLSYGQKWGMVAILTMCGFWSSLGSPIYYPALRQLEKQFNVDENMVNVTVVVYLLFQGISPTVSGGLADCFGRRPIILAGMLIYVIASIGLACAPSYGVIIFLRCIQSIGISPTIAISSGVVGDFTLKHERGTFVGATSGFVLLGQCFGSLIGAVLTARWDWRAIFWFLTIGCGSCFLIAFLILPETKRTIAGNLSIKPKRFINRAPIFLLGPVRRRFKYDNPDYETLDPTIPKLDLSSAGKILVLPEIILSLFPSGLLFAMWTLMLSSISSGLSVAPYNYHLVIIGVCYLPGGIGGLMGSFFTGRIIDMYFKRKIKKFEQDKANGLIPQDAEINMFKVRLVCLLPQNFLAVVAYLLFGWSIDKGWRIESILITSFVCSYCAMSTLSTSTTLLVDLYPTKSSTASSCFNFVRCSLSTIFMGCFAKMKAAMTVGGTFTFLCALVFFFNFLMFIPMKYGMKWREDRLLKQQRQSWLNTLAVKAKKGTKRDQNDNHN
SIO_010081: YNL065W
subclass of: SO_0000673
so part of: YNL065W
location: 503724..505484
location: region:503724-505484:1
so has part: feature:503724-505484:1:exon

NP_014334.3
type: Protein
SIO_000068: ncbiprotein

S000005009
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:503724-505484:1:exon

YNL064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HSP40
alternative label: MAB3
alternative label: MAS5
gene: YDJ1
locus tag: YNL064C
gene synonym: HSP40; MAB3; MAS5
so part of: sequence
location: complement(<505868..>507097)
location: region:505868-507097:-1
so has part: feature:505868-507097:-1:exon
subclass of: SO_0000010

855661
type: Gene
SIO_000068: ncbigene

position:505868:-1
position: 505868
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507097:-1
position: 507097
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:505868-507097:-1:exon

YNL064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HSP40
alternative label: MAB3
alternative label: MAS5
gene: YDJ1
locus tag: YNL064C
gene synonym: HSP40; MAB3; MAS5
product: type I HSP40 co-chaperone YDJ1
transcript id: NM_001182902.1
SIO_010081: YNL064C
subclass of: SO_0000673
so part of: YNL064C
location: complement(<505868..>507097)
location: region:505868-507097:-1
so has part: feature:505868-507097:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:505868-507097:-1:exon

YNL064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HSP40
alternative label: MAB3
alternative label: MAS5
gene: YDJ1
locus tag: YNL064C
gene synonym: HSP40; MAB3; MAS5
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:1400408|PMID:15342786]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1869583|PMID:8144572|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9674429]
experiment: EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:1869583]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9774392]
experiment: EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]
experiment: EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:10567418]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756]
experiment: EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:1729605]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:15252059|PMID:15342786]
experiment: EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:1473150]
note: Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant
codon start: 1
product: type I HSP40 co-chaperone YDJ1
translation: MVKETKFYDILGVPVTATDVEIKKAYRKCALKYHPDKNPSEEAAEKFKEASAAYEILSDPEKRDIYDQFGEDGLSGAGGAGGFPGGGFGFGDDIFSQFFGAGGAQRPRGPQRGKDIKHEISASLEELYKGRTAKLALNKQILCKECEGRGGKKGAVKKCTSCNGQGIKFVTRQMGPMIQRFQTECDVCHGTGDIIDPKDRCKSCNGKKVENERKILEVHVEPGMKDGQRIVFKGEADQAPDVIPGDVVFIVSERPHKSFKRDGDDLVYEAEIDLLTAIAGGEFALEHVSGDWLKVGIVPGEVIAPGMRKVIEGKGMPIPKYGGYGNLIIKFTIKFPENHFTSEENLKKLEEILPPRIVPAIPKKATVDECVLADFDPAKYNRTRASRGGANYDSDEEEQGGEGVQCASQ
SIO_010081: YNL064C
subclass of: SO_0000673
so part of: YNL064C
location: complement(505868..507097)
location: region:505868-507097:-1
so has part: feature:505868-507097:-1:exon

NP_014335.1
type: Protein
SIO_000068: ncbiprotein

S000005008
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:505868-507097:-1:exon

YNL063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTQ1
locus tag: YNL063W
so part of: sequence
location: <507758..>508702
location: region:507758-508702:1
so has part: feature:507758-508702:1:exon
subclass of: SO_0000010

855662
type: Gene
SIO_000068: ncbigene

position:507758:1
position: 507758
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:508702:1
position: 508702
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:507758-508702:1:exon

YNL063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTQ1
locus tag: YNL063W
product: S-adenosylmethionine-dependent methyltransferase
transcript id: NM_001182901.1
SIO_010081: YNL063W
subclass of: SO_0000673
so part of: YNL063W
location: <507758..>508702
location: region:507758-508702:1
so has part: feature:507758-508702:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:507758-508702:1:exon

YNL063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTQ1
locus tag: YNL063W
EC number: 2.1.1.297
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]
experiment: EXISTENCE:genetic interaction:GO:0006451 translational readthrough [PMID:16321977]
experiment: EXISTENCE:mutant phenotype:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]
note: S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
codon start: 1
product: S-adenosylmethionine-dependent methyltransferase
translation: MPRISTSLIRKASRIRPGLHLLLPECRTLEQAKLEYKWLTEELPPDKSIRWACLQRYKHVPLQYILRSQPFGALDIVCKPGVLIPRWETEEWVMAIIRALNNSMLSRHTIPLHICDTFTGTGCIALALSHGIANCTFTAIDVSTRAIKLVKENMLKNKVSGGKLVQHNILSSKASDEYPSHIDILTGNPPYIRKRDFNRDVKTSVKLFEPRLALVGELECYINLVNYWLPKTDSFFYEIGDVEQFNYVERRIKEDSYLSRIWSIGLKYDSNGKARVVYGFKATPKGRILHQIFASFGTIRHLATALSGHKANCN
SIO_010081: YNL063W
subclass of: SO_0000673
so part of: YNL063W
location: 507758..508702
location: region:507758-508702:1
so has part: feature:507758-508702:1:exon

NP_014336.1
type: Protein
SIO_000068: ncbiprotein

S000005007
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:507758-508702:1:exon

YNL062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TRM6
gene: GCD10
locus tag: YNL062C
gene synonym: TRM6
so part of: sequence
location: complement(<508776..>510212)
location: region:508776-510212:-1
so has part: feature:508776-510212:-1:exon
subclass of: SO_0000010

855663
type: Gene
SIO_000068: ncbigene

position:508776:-1
position: 508776
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:510212:-1
position: 510212
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:508776-510212:-1:exon

YNL062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TRM6
gene: GCD10
locus tag: YNL062C
gene synonym: TRM6
product: tRNA 1-methyladenosine methyltransferase subunit GCD10
transcript id: NM_001182900.3
SIO_010081: YNL062C
subclass of: SO_0000673
so part of: YNL062C
location: complement(<508776..>510212)
location: region:508776-510212:-1
so has part: feature:508776-510212:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:508776-510212:-1:exon

YNL062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TRM6
gene: GCD10
locus tag: YNL062C
gene synonym: TRM6
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9851972]
experiment: EXISTENCE:direct assay:GO:0016429 tRNA (adenine-N1-)-methyltransferase activity [PMID:10779558]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10779558]
experiment: EXISTENCE:direct assay:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]
experiment: EXISTENCE:physical interaction:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]
note: Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
codon start: 1
product: tRNA 1-methyladenosine methyltransferase subunit GCD10
translation: MNALTTIDFNQHVIVRLPSKNYKIVELKPNTSVSLGKFGAFEVNDIIGYPFGLTFEIYYDGEEVSSDENRDSKPKNKIPIGKVRLLSQEIKDVNNDKDDGQSEPPLSIKEKSVSLELSSIDSSATNQNLVNMGSKAQELTVEEIEKMKQESLSSKEIIDKIIKSHKSFHNKTVYSQEKYVNRKKQKFAKYFTVEYLSSSNLLQFLIDKGDIQRVLDMSQESMGMLLNLANIQSEGNYLCMDETGGLLVYFLLERMFGGDNESKSKGKVIVIHENEHANLDLLKFANYSEKFIKEHVHTISLLDFFEPPTLQEIQSRFTPLPKEEARALKGGKKNSYYRKLRWYNTQWQILELTGEFLYDGLVMATTLHLPTLVPKLAEKIHGSRPIVCYGQFKETLLELAHTLYSDLRFLAPSILETRCRPYQSIRGKLHPLMTMKGGGGYLMWCHRVIPAPEPVSENATAADSSEKLAEHGAKKQKI
SIO_010081: YNL062C
subclass of: SO_0000673
so part of: YNL062C
location: complement(508776..510212)
location: region:508776-510212:-1
so has part: feature:508776-510212:-1:exon

NP_014337.3
type: Protein
SIO_000068: ncbiprotein

S000005006
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:508776-510212:-1:exon

YNL061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNA1
gene: NOP2
locus tag: YNL061W
gene synonym: YNA1
so part of: sequence
location: <510540..>512396
location: region:510540-512396:1
so has part: feature:510540-512396:1:exon
subclass of: SO_0000010

855664
type: Gene
SIO_000068: ncbigene

position:510540:1
position: 510540
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:512396:1
position: 512396
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:510540-512396:1:exon

YNL061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNA1
gene: NOP2
locus tag: YNL061W
gene synonym: YNA1
product: rRNA (cytosine-C5-)-methyltransferase NOP2
transcript id: NM_001182899.3
SIO_010081: YNL061W
subclass of: SO_0000673
so part of: YNL061W
location: <510540..>512396
location: region:510540-512396:1
so has part: feature:510540-512396:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:510540-512396:1:exon

YNL061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNA1
gene: NOP2
locus tag: YNL061W
gene synonym: YNA1
EC number: 2.1.1.310
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:26196125|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22735702|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]
experiment: EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8972218]
experiment: EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:8972218]
experiment: EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]
experiment: EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]
note: rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer
codon start: 1
product: rRNA (cytosine-C5-)-methyltransferase NOP2
translation: MGSRRHKNKQAAPPTLEEFQARKEKKANRKLEKGKRPSTTQGDEVSDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKARKSLFDDEEDDDEAGLVDEELKDEFDLEQEYDYDEDEDNDAHPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEEAEEAEMELVEAENMQPRADILPTEEQEEMMAQETPNLTSTRTRMIEIVKVLENFKTLGAEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLFSPAEAMEFFEANEIARPITIRTNTLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGATPEYLAGHYILQAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRTKSLIANIHRLGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAIGKEAFTSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIGPSSFDDNQASAKEKETAARKEALEEGIIHSDFATFEDEEDDKYIEKSVKNNLLKKGVNPKAKRPSNEK
SIO_010081: YNL061W
subclass of: SO_0000673
so part of: YNL061W
location: 510540..512396
location: region:510540-512396:1
so has part: feature:510540-512396:1:exon

NP_014338.3
type: Protein
SIO_000068: ncbiprotein

S000005005
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:510540-512396:1:exon

YNL059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARP5
locus tag: YNL059C
so part of: sequence
location: complement(<512668..>514935)
location: region:512668-514935:-1
so has part: feature:512668-514935:-1:exon
subclass of: SO_0000010

855665
type: Gene
SIO_000068: ncbigene

position:512668:-1
position: 512668
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:514935:-1
position: 514935
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:512668-514935:-1:exon

YNL059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARP5
locus tag: YNL059C
product: Arp5p
transcript id: NM_001182898.1
SIO_010081: YNL059C
subclass of: SO_0000673
so part of: YNL059C
location: complement(<512668..>514935)
location: region:512668-514935:-1
so has part: feature:512668-514935:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:512668-514935:-1:exon

YNL059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARP5
locus tag: YNL059C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149|PMID:10923024]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:26306040]
experiment: EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900|PMID:15525518]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12887900]
experiment: EXISTENCE:mutant phenotype:GO:0031011 Ino80 complex [PMID:12887900]
experiment: EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:15525518]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction
codon start: 1
product: Arp5p
translation: MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDFGSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDGPFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNVPGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQAVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVVVEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVRDQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDKTAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQQWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNVKQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERLLLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEVIFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKERIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPEYIKEHKLGNTKYFED
SIO_010081: YNL059C
subclass of: SO_0000673
so part of: YNL059C
location: complement(512668..514935)
location: region:512668-514935:-1
so has part: feature:512668-514935:-1:exon

NP_014339.1
type: Protein
SIO_000068: ncbiprotein

S000005004
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:512668-514935:-1:exon

YNL058C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL058C
so part of: sequence
location: complement(<515763..>516713)
location: region:515763-516713:-1
so has part: feature:515763-516713:-1:exon
subclass of: SO_0000010

855667
type: Gene
SIO_000068: ncbigene

position:515763:-1
position: 515763
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516713:-1
position: 516713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:515763-516713:-1:exon

YNL058C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL058C
product: uncharacterized protein
transcript id: NM_001182897.1
SIO_010081: YNL058C
subclass of: SO_0000673
so part of: YNL058C
location: complement(<515763..>516713)
location: region:515763-516713:-1
so has part: feature:515763-516713:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:515763-516713:-1:exon

YNL058C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL058C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MVKKNFIPSVSLVRRDLPTLVTTTTSSTALSKPTSSVVSETSSKSLPSLTSSAFSTSSGATSSSSLIVASITPPSTAGNPFILNAADKPNGTVYIAVGAVIGAIFISILIWWLVSSYLSRRFTMTNSYANDSKNLYRGHHKHSSSLQSNPFDINDEKSYMQDDWDSMSQLESSQYEDAASPFNPIQDPFTDNRRSLFISPTLQVSQYEKSHSRHQSKDTNIFIDDPFLYVGTYLEEEEEEEEERKLNLNRPQRAASPERKEKKINSMEGYHKRNQSSLGLIPVASATSNTSSPKKAHKRQAPSMFLDDVLNGREII
SIO_010081: YNL058C
subclass of: SO_0000673
so part of: YNL058C
location: complement(515763..516713)
location: region:515763-516713:-1
so has part: feature:515763-516713:-1:exon

NP_014340.1
type: Protein
SIO_000068: ncbiprotein

S000005003
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:515763-516713:-1:exon

YNL056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OCA2
locus tag: YNL056W
so part of: sequence
location: <517249..>517842
location: region:517249-517842:1
so has part: feature:517249-517842:1:exon
subclass of: SO_0000010

855668
type: Gene
SIO_000068: ncbigene

position:517249:1
position: 517249
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:517842:1
position: 517842
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517249-517842:1:exon

YNL056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OCA2
locus tag: YNL056W
product: Oca2p
transcript id: NM_001182895.3
SIO_010081: YNL056W
subclass of: SO_0000673
so part of: YNL056W
location: <517249..>517842
location: region:517249-517842:1
so has part: feature:517249-517842:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517249-517842:1:exon

YNL056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OCA2
locus tag: YNL056W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
codon start: 1
product: Oca2p
translation: MKYIPPLNFSPVVSTDVSLYRSGYPMPLNYSFIKHQLHLKTIIYIGDKDRPLEEYQSFLESEKIKYYHIFMDSSRDEGIQERMNQVLHLVLDVRNYPILVHSNKGKHRVGVVVGIIRKLLQGWSTAGICQEYGLFSGGMKDGVDLEFITMFETNLKIPRNVIPGFAKHCLYLNELEAAEGSDDESGSESILTAKQPI
SIO_010081: YNL056W
subclass of: SO_0000673
so part of: YNL056W
location: 517249..517842
location: region:517249-517842:1
so has part: feature:517249-517842:1:exon

NP_014342.3
type: Protein
SIO_000068: ncbiprotein

S000005001
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517249-517842:1:exon

YNL055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OMP2
gene: POR1
locus tag: YNL055C
gene synonym: OMP2
so part of: sequence
location: complement(<517994..>518845)
location: region:517994-518845:-1
so has part: feature:517994-518845:-1:exon
subclass of: SO_0000010

855669
type: Gene
SIO_000068: ncbigene

position:517994:-1
position: 517994
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:518845:-1
position: 518845
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517994-518845:-1:exon

YNL055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OMP2
gene: POR1
locus tag: YNL055C
gene synonym: OMP2
product: porin POR1
transcript id: NM_001182894.1
SIO_010081: YNL055C
subclass of: SO_0000673
so part of: YNL055C
location: complement(<517994..>518845)
location: region:517994-518845:-1
so has part: feature:517994-518845:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517994-518845:-1:exon

YNL055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OMP2
gene: POR1
locus tag: YNL055C
gene synonym: OMP2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:7499333|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0006811 ion transport [PMID:9593723]
experiment: EXISTENCE:direct assay:GO:0008308 voltage-gated anion channel activity [PMID:9593723]
experiment: EXISTENCE:direct assay:GO:0048039 ubiquinone binding [PMID:28051849]
experiment: EXISTENCE:genetic interaction:GO:0071902 positive regulation of protein serine/threonine kinase activity [PMID:23104570]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17822411]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11488609]
experiment: EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:29359182]
experiment: EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:18768136]
experiment: EXISTENCE:mutant phenotype:GO:0051027 DNA transport [PMID:19056337]
experiment: EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]
note: Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glutathione pools of the intermembrane space (IMS) and the cytosol; interacts with Om45 and Om14 in the outer membrane; phosphorylated; protein abundance increases in response to DNA replication stress
codon start: 1
product: porin POR1
translation: MSPPVYSDISRNINDLLNKDFYHATPAAFDVQTTTANGIKFSLKAKQPVKDGPLSTNVEAKLNDKQTGLGLTQGWSNTNNLQTKLEFANLTPGLKNELITSLTPGVAKSAVLNTTFTQPFFTARGAFDLCLKSPTFVGDLTMAHEGIVGGAEFGYDISAGSISRYAMALSYFAKDYSLGATLNNEQITTVDFFQNVNAFLQVGAKATMNCKLPNSNVNIEFATRYLPDASSQVKAKVSDSGIVTLAYKQLLRPGVTLGVGSSFDALKLSEPVHKLGWSLSFDA
SIO_010081: YNL055C
subclass of: SO_0000673
so part of: YNL055C
location: complement(517994..518845)
location: region:517994-518845:-1
so has part: feature:517994-518845:-1:exon

NP_014343.1
type: Protein
SIO_000068: ncbiprotein

S000005000
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517994-518845:-1:exon

YNCN0008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0008C
so part of: sequence
location: complement(519099..519169)
location: region:519099-519169:-1
so has part: feature:519099-519169:-1:exon
subclass of: SO_0000663

855670
type: Gene
SIO_000068: ncbigene

position:519099:-1
position: 519099
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:519169:-1
position: 519169
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519099-519169:-1:exon

YNCN0008C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0008C
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0008C
subclass of: SO_0000673
so part of: YNCN0008C
location: complement(519099..519169)
location: region:519099-519169:-1
so has part: feature:519099-519169:-1:exon

S000006544
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519099-519169:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YNLWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YNLWTy1-2
so part of: sequence
location: 519163..525062
location: region:519163-525062:1
so has part: feature:519163-525062:1:region

S000007142
type: SGD
SIO_000068: sgd

position:519163:1
position: 519163
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:525062:1
position: 525062
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519163-525062:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 519163..519496
location: region:519163-519496:1
so has part: feature:519163-519496:1:region

S000007136
type: SGD
SIO_000068: sgd

position:519496:1
position: 519496
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519163-519496:1:region

YNL054W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL054W-B
so part of: sequence
location: <519456..>524706
location: region:519456-524706:1
so has part: feature:519456-524706:1:exon
subclass of: SO_0000010

855672
type: Gene
SIO_000068: ncbigene

position:519456:1
position: 519456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524706:1
position: 524706
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519456-524706:1:exon

YNL054W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL054W-B
product: gag-pol fusion protein
transcript id: NM_001281536.2
SIO_010081: YNL054W-B
subclass of: SO_0000673
so part of: YNL054W-B
location: <519456..>524706
location: region:519456-524706:1
so has part: feature:519456-524706:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:519456-524706:1:exon

YNL054W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL054W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: TyB Gag-Pol protein; proteolytically processed to make the Gag, reverse transcriptase (RT), protease (PR), and integrase (IN) proteins that are required for retrotransposition
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSDWSFYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISKSDILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHTSKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTKLSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIEQCDMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVHLNPKGKKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YNL054W-B
subclass of: SO_0000673
so part of: YNL054W-B
location: join(519456..520760,520762..524706)
location: region:519456-524706:1
so has part: feature:519456-520760:1:exon
so has part: feature:520762-524706:1:exon

NP_001268465.1
type: Protein
SIO_000068: ncbiprotein

S000007385
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519456-520760:1:exon

position:520760:1
position: 520760
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:520762-524706:1:exon

position:520762:1
position: 520762
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL054W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL054W-A
so part of: sequence
location: <519456..>520778
location: region:519456-520778:1
so has part: feature:519456-520778:1:exon
subclass of: SO_0000010

855671
type: Gene
SIO_000068: ncbigene

position:520778:1
position: 520778
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519456-520778:1:exon

YNL054W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL054W-A
product: gag protein
transcript id: NM_001184413.3
SIO_010081: YNL054W-A
subclass of: SO_0000673
so part of: YNL054W-A
location: <519456..>520778
location: region:519456-520778:1
so has part: feature:519456-520778:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:519456-520778:1:exon

YNL054W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL054W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSDWSFYGRPSMIPYTPYQMSPMYFPPGPHSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFLNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YNL054W-A
subclass of: SO_0000673
so part of: YNL054W-A
location: 519456..520778
location: region:519456-520778:1
so has part: feature:519456-520778:1:exon

NP_058180.1
type: Protein
SIO_000068: ncbiprotein

S000007384
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519456-520778:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 524729..525062
location: region:524729-525062:1
so has part: feature:524729-525062:1:region

S000007137
type: SGD
SIO_000068: sgd

position:524729:1
position: 524729
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:524729-525062:1:region

YNL054W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VAC7
locus tag: YNL054W
so part of: sequence
location: <526086..>529583
location: region:526086-529583:1
so has part: feature:526086-529583:1:exon
subclass of: SO_0000010

855673
type: Gene
SIO_000068: ncbigene

position:526086:1
position: 526086
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:529583:1
position: 529583
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:526086-529583:1:exon

YNL054W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VAC7
locus tag: YNL054W
product: Vac7p
transcript id: NM_001182893.3
SIO_010081: YNL054W
subclass of: SO_0000673
so part of: YNL054W
location: <526086..>529583
location: region:526086-529583:1
so has part: feature:526086-529583:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:526086-529583:1:exon

YNL054W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VAC7
locus tag: YNL054W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9372916|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:9372916]
experiment: EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]
experiment: EXISTENCE:genetic interaction:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:11950935]
experiment: EXISTENCE:genetic interaction:GO:0033674 positive regulation of kinase activity [PMID:11950935]
experiment: EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:17699591]
experiment: EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]
note: Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway
codon start: 1
product: Vac7p
translation: MTEEDRKLTVETETVEAPVANNLLLSNNSNVVAPNPSIPSASTSTSPLHREIVDDSVATANTTSNVVQHNLPTIDNNLMDSDATSHNQDHWHSDINRAGTSMSTSDIPTDLHLEHIGSVSSTNNNSNNALINHNPLSSHLSNPSSSLRNKKSSLLVASNPAFASDVELSKKKPAVISNNMPTSNIALYQTARSANIHGPSSTSASKAFRKASAFSNNTAPSTSNNIGSNTPPAPLLPLPSLSQQNKPKIIERPTMHVTNSREILLGENLLDDTKAKNAPANSTTHDNGPVANDGLRIPNHSNADDNENNNKMKKNKNINSGKNERNDDTSKICTTSTKTAPSTAPLGSTDNTQALTASVSSSNADNHNNNKKKTSSNNNGNNSNSASNKTNADIKNSNADLSASTSNNNAINDDSHESNSEKPTKADFFAARLATAVGENEISDSEETFVYESAANSTKNLIFPDSSSQQQQQQQQPPKQQQQQQNHGITSKISAPLLNNNKKLLSRLKNSRHISTGAILNNTIATISTNPNLNSNVMQNNNNLMSGHNHLDELSSIKQEPPHQLQQQQPPMDVQSVDSYTSDNPDSNVIAKSPDKRSSLVSLSKVSPHLLSSTSSNGNTISCPNVATNSQELEPNNDISTKKSLSNSTLRHSSANRNSNYGDNKRPLRTTVSKIFDSNPNGAPLRRYSGVPDHVNLEDYIEQPHNYPTMQNSVKKDEFYNSRNNKFPHGLNFYGDNNVIEEENNGDSSNVNRPQHTNLQHEFIPEDNESDENDIHSMFYYNHKNDLETKPLISDYGEDEDVDDYDRPNATFNSYYGSASNTHELPLHGRMPSRSNNDYYDFMVGNNTGNNNQLNEYTPLRMKRGQRHLSRTNNSIMNGSIHMNGNDDVTHSNINNNDIVGYSPHNFYSRKSPFVKVKNFLYLAFVISSLLMTGFILGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDSNGDCTVMEQERKILQITTNLSLVEESANNDISGGNIETVLLGTAKKLETPLKFQGGAFNRNYDVSVSSVKLLSPGSREAKHENDDDDDDDGDDGDDENNTNERQYKSKPNARDDKEDDTKKWKLLIKHDYELIVRGSMKYEVPFFNTQKSTAIQKDSMVHPGKK
SIO_010081: YNL054W
subclass of: SO_0000673
so part of: YNL054W
location: 526086..529583
location: region:526086-529583:1
so has part: feature:526086-529583:1:exon

NP_014344.3
type: Protein
SIO_000068: ncbiprotein

S000004999
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:526086-529583:1:exon

YNL053W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSG5
locus tag: YNL053W
so part of: sequence
location: <529942..>531411
location: region:529942-531411:1
so has part: feature:529942-531411:1:exon
subclass of: SO_0000010

855674
type: Gene
SIO_000068: ncbigene

position:529942:1
position: 529942
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:531411:1
position: 531411
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:529942-531411:1:exon

YNL053W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSG5
locus tag: YNL053W
product: tyrosine/serine/threonine protein phosphatase MSG5
transcript id: NM_001182892.3
SIO_010081: YNL053W
subclass of: SO_0000673
so part of: YNL053W
location: <529942..>531411
location: region:529942-531411:1
so has part: feature:529942-531411:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:529942-531411:1:exon

YNL053W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSG5
locus tag: YNL053W
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17952059|PMID:17963515]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17952059|PMID:17963515|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008138 protein tyrosine/serine/threonine phosphatase activity [PMID:8306972]
experiment: EXISTENCE:direct assay:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:14703512]
experiment: EXISTENCE:direct assay:GO:1903138 negative regulation of cell wall integrity MAPK cascade [PMID:14703512|PMID:8306972]
experiment: EXISTENCE:genetic interaction:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:8306972]
experiment: EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:11923319]
experiment: EXISTENCE:genetic interaction:GO:1903138 negative regulation of cell wall integrity MAPK cascade [PMID:10625705|PMID:11923319]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:12556475|PMID:8306972]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:14703512]
experiment: EXISTENCE:mutant phenotype:GO:0071701 regulation of MAPK export from nucleus [PMID:12556475|PMID:17963515]
experiment: EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:14703512]
experiment: EXISTENCE:mutant phenotype:GO:1903138 negative regulation of cell wall integrity MAPK cascade [PMID:10625705|PMID:14703512|PMID:8306972]
note: Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts
codon start: 1
product: tyrosine/serine/threonine protein phosphatase MSG5
translation: MQFHSDKQHLDSKTDIDFKPNSPRSLQNRNTKNLSLDIAALHPLMEFSSPSQDVPGSVKFPSPTPLNLFMKPKPIVLEKCPPKVSPRPTPPSLSMRRSEASIYTLPTSLKNRTVSPSVYTKSSTVSSISKLSSSSPLSSFSEKPHLNRVHSLSVKTKDLKLKGIRGRSQTISGLETSTPISSTREGTLDSTDVNRFSNQKNMQTTLIFPEEDSDLNIDMVHAEIYQRTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNSPGEEGETVHMPEEDDIGNNEVSSTTKSYSSASFRSFPMVTNLSSSPNDSSVNSSEVTPRTPATLTGARTALATERGEDDEHCKSLSQPADSLEASVDNESISTAPEQMMFLP
SIO_010081: YNL053W
subclass of: SO_0000673
so part of: YNL053W
location: 529942..531411
location: region:529942-531411:1
so has part: feature:529942-531411:1:exon

NP_014345.3
type: Protein
SIO_000068: ncbiprotein

S000004998
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:529942-531411:1:exon

YNL052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX5A
locus tag: YNL052W
so part of: sequence
location: <531725..>532186
location: region:531725-532186:1
so has part: feature:531725-532186:1:exon
subclass of: SO_0000010

855675
type: Gene
SIO_000068: ncbigene

position:531725:1
position: 531725
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:532186:1
position: 532186
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:531725-532186:1:exon

YNL052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX5A
locus tag: YNL052W
product: cytochrome c oxidase subunit Va
transcript id: NM_001182891.1
SIO_010081: YNL052W
subclass of: SO_0000673
so part of: YNL052W
location: <531725..>532186
location: region:531725-532186:1
so has part: feature:531725-532186:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:531725-532186:1:exon

YNL052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX5A
locus tag: YNL052W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]
experiment: EXISTENCE:mutant phenotype:GO:0004129 cytochrome-c oxidase activity [PMID:1847916]
note: Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication
codon start: 1
product: cytochrome c oxidase subunit Va
translation: MLRNTFTRAGGLSRITSVRFAQTHALSNAAVMDLQSRWENMPSTEQQDIVSKLSERQKLPWAQLTEPEKQAVWYISYGEWGPRRPVLNKGDSSFIAKGVAAGLLFSVGLFAVVRMAGGQDAKTMNKEWQLKSDEYLKSKNANPWGGYSQVQSK
SIO_010081: YNL052W
subclass of: SO_0000673
so part of: YNL052W
location: 531725..532186
location: region:531725-532186:1
so has part: feature:531725-532186:1:exon

NP_014346.1
type: Protein
SIO_000068: ncbiprotein

S000004997
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:531725-532186:1:exon

YNL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: API4
alternative label: COD4
gene: COG5
locus tag: YNL051W
gene synonym: API4; COD4
so part of: sequence
location: <532659..>533870
location: region:532659-533870:1
so has part: feature:532659-533870:1:exon
subclass of: SO_0000010

855676
type: Gene
SIO_000068: ncbigene

position:532659:1
position: 532659
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:533870:1
position: 533870
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:532659-533870:1:exon

YNL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: API4
alternative label: COD4
gene: COG5
locus tag: YNL051W
gene synonym: API4; COD4
product: Golgi transport complex subunit COG5
transcript id: NM_001182890.1
SIO_010081: YNL051W
subclass of: SO_0000673
so part of: YNL051W
location: <532659..>533870
location: region:532659-533870:1
so has part: feature:532659-533870:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:532659-533870:1:exon

YNL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: API4
alternative label: COD4
gene: COG5
locus tag: YNL051W
gene synonym: API4; COD4
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
note: Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG5
translation: MTIAPMANDLEDFESLLEPDFDAKQFGNDLLKATNNNDTTILDLNTPLKKLNYDLHEIDSRIDQLMNSNPLEIIELIYKNEHVNSTIVGELKPSLGYMNMSYDRLKNQVLDPYERARKVQLALSKVYQTSFLLRGALLYIHLSNKLNALSKTAQLSTSTAINLASLHYQLEITLEENKNLKSLRKIKQLDQDIVSPNKRELITFLSLQMCKECLNSIKIKSNKEIISQLAYSLYLLSSQEFESAINKIVLSNVTMSSQILSKILNSIRMFPDAFNEVVEKGYNIYILETLLQNIKTDNVTNSSRSIAANKSRLGNLLSEYTSMKSKAGSGTPRDLFWSKVSSAFKKDFDISVNRGGPVGKSLLKNKDFIINTMKQSMKKSSDNSDYQSYLDVMLNSVSISLNK
SIO_010081: YNL051W
subclass of: SO_0000673
so part of: YNL051W
location: 532659..533870
location: region:532659-533870:1
so has part: feature:532659-533870:1:exon

NP_014347.1
type: Protein
SIO_000068: ncbiprotein

S000004996
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:532659-533870:1:exon

YNL050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL050C
so part of: sequence
location: complement(<534079..>534982)
location: region:534079-534982:-1
so has part: feature:534079-534982:-1:exon
subclass of: SO_0000010

855677
type: Gene
SIO_000068: ncbigene

position:534079:-1
position: 534079
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:534982:-1
position: 534982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:534079-534982:-1:exon

YNL050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL050C
product: uncharacterized protein
transcript id: NM_001182889.3
SIO_010081: YNL050C
subclass of: SO_0000673
so part of: YNL050C
location: complement(join(<534079..534874,534966..>534982))
location: region:534079-534982:-1
so has part: feature:534966-534982:-1:exon
so has part: feature:534079-534874:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:534966-534982:-1:exon

position:534966:-1
position: 534966
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:534079-534874:-1:exon

position:534874:-1
position: 534874
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YNL050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL050C
note: hypothetical protein; YNL050c is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSEFKIVSRKDLYNEGEGLGEDYDSNSSSKNNSEHVEVLVPPTEFEFVEVERTDSSLDLKESNNSAHEQKEEKQEEFEFPLFSFGVVEASTSPAQEEQGSSTQEKDTPQTEVSLMKISLKEPEEEIINQERPKDYYFASYSADQKLQFQQSSIDYDVIIQESTKILEDDLRIRDKWPYCQGRIIDLYKHNARIELEQQKELKIKKRRPGQKQRAAKKLALERTKERDTKAREIKKQLKKKFHKRGGKKNKKKVPLNPLAKAGSTPKFRTE
SIO_010081: YNL050C
subclass of: SO_0000673
so part of: YNL050C
location: complement(join(534079..534874,534966..534982))
location: region:534079-534982:-1
so has part: feature:534966-534982:-1:exon
so has part: feature:534079-534874:-1:exon

NP_014348.3
type: Protein
SIO_000068: ncbiprotein

S000004995
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:534966-534982:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:534079-534874:-1:exon

YNL049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISS1
gene: SFB2
locus tag: YNL049C
gene synonym: ISS1
so part of: sequence
location: complement(<535281..>537911)
location: region:535281-537911:-1
so has part: feature:535281-537911:-1:exon
subclass of: SO_0000010

855678
type: Gene
SIO_000068: ncbigene

position:535281:-1
position: 535281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:537911:-1
position: 537911
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535281-537911:-1:exon

YNL049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISS1
gene: SFB2
locus tag: YNL049C
gene synonym: ISS1
product: COPII subunit SFB2
transcript id: NM_001182888.1
SIO_010081: YNL049C
subclass of: SO_0000673
so part of: YNL049C
location: complement(<535281..>537911)
location: region:535281-537911:-1
so has part: feature:535281-537911:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:535281-537911:-1:exon

YNL049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISS1
gene: SFB2
locus tag: YNL049C
gene synonym: ISS1
experiment: EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514]
experiment: EXISTENCE:genetic interaction:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514|PMID:12941277]
experiment: EXISTENCE:physical interaction:GO:0030127 COPII vesicle coat [PMID:10749860|PMID:10753972]
note: Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication
codon start: 1
product: COPII subunit SFB2
translation: MSHHKKRVYPQAQVPYIASMPIVAEQQQSQQQIDQTAYAMGNLQLNNRANSFTQLAQNQQFPGSGKVVNQLYPVDLFTELPPPIRDLSLPPLPITISQDNIVTPSEYSNVPYQYVRSTLKAVPKTNSLLKKTKLPFAIVIRPYLHLQDSDNQVPLNTDGVIVRCRRCRSYMNPFVVFINQGRKWQCNICRFKNDVPFGFDQNLQGAPINRYERNEIKNSVVDYLAPVEYSVREPPPSVYVFLLDVSQNAVKNGLLATSARTILENIEFLPNHDGRTRIAIICVDHSLHYFYVPLDDDYEVSDEDDEESDGEEEDEDEEEEDVDNSETIQMFDIGDLDEPFLPMPSDELVVPLKYCKNNLETLLKKIPEIFQDTHSSKFALGPALKAASNLIKSTGGKVEVISSTLPNTGIGKLKKRSEQGILNTPKESSQLLSCKDSFYKTFTIECNKLQITVDMFLASEDYMDVATLSHLGRFSGGQTHFYPGFNATSLNDVTKFTRELSRHLSMDISMEAVMRVRCSTGLRATSFFGHFFNRSSDLCAFSTMPRDQSYLFGISIEDSLMAEYCYLQVSTLLTLNTGERRIRVMTLALPTSESAREVFASADQLAITDFMTQNAVTKALNSSMYSARDFITKSLEDILNAYKKEISMSNINSVTSLNLCANLRMLPLLMNGLSKHIALRPGVVPSDYRASALNRLETEPLHYLIKSIYPTVYSLHDMPDEVGLPDFEGKTVLPEPINATISLFERYGLYLIDNSAELFLWVGGDAVPELLIDVFNTDTISQIPVGKSELPLLNDSPFNERLRRIIGRIRENNDTITFQSLYIIRGPSINEPANLNSEKDMASLRLWVLSTLVEDKVLNCASYREYLQSMKTSINR
SIO_010081: YNL049C
subclass of: SO_0000673
so part of: YNL049C
location: complement(535281..537911)
location: region:535281-537911:-1
so has part: feature:535281-537911:-1:exon

NP_014349.1
type: Protein
SIO_000068: ncbiprotein

S000004994
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:535281-537911:-1:exon

YNL048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALG11
locus tag: YNL048W
so part of: sequence
location: <538173..>539819
location: region:538173-539819:1
so has part: feature:538173-539819:1:exon
subclass of: SO_0000010

855679
type: Gene
SIO_000068: ncbigene

position:538173:1
position: 538173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:539819:1
position: 539819
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538173-539819:1:exon

YNL048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALG11
locus tag: YNL048W
product: alpha-1,2-mannosyltransferase ALG11
transcript id: NM_001182887.1
SIO_010081: YNL048W
subclass of: SO_0000673
so part of: YNL048W
location: <538173..>539819
location: region:538173-539819:1
so has part: feature:538173-539819:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538173-539819:1:exon

YNL048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALG11
locus tag: YNL048W
EC number: 2.4.1.131
experiment: EXISTENCE:direct assay:GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:16878994]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11278778]
experiment: EXISTENCE:direct assay:GO:0006490 oligosaccharide-lipid intermediate biosynthetic process [PMID:16878994]
experiment: EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:11278778]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:11278778]
note: Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
codon start: 1
product: alpha-1,2-mannosyltransferase ALG11
translation: MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMSKDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRVMGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG
SIO_010081: YNL048W
subclass of: SO_0000673
so part of: YNL048W
location: 538173..539819
location: region:538173-539819:1
so has part: feature:538173-539819:1:exon

NP_014350.1
type: Protein
SIO_000068: ncbiprotein

S000004993
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538173-539819:1:exon

YNL047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LIT1
gene: SLM2
locus tag: YNL047C
gene synonym: LIT1
so part of: sequence
location: complement(<539911..>541881)
location: region:539911-541881:-1
so has part: feature:539911-541881:-1:exon
subclass of: SO_0000010

855680
type: Gene
SIO_000068: ncbigene

position:539911:-1
position: 539911
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:541881:-1
position: 541881
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:539911-541881:-1:exon

YNL047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LIT1
gene: SLM2
locus tag: YNL047C
gene synonym: LIT1
product: phosphatidylinositol 4,5-bisphosphate-binding protein
transcript id: NM_001182886.3
SIO_010081: YNL047C
subclass of: SO_0000673
so part of: YNL047C
location: complement(<539911..>541881)
location: region:539911-541881:-1
so has part: feature:539911-541881:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:539911-541881:-1:exon

YNL047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LIT1
gene: SLM2
locus tag: YNL047C
gene synonym: LIT1
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15372071|PMID:15689497]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0001558 regulation of cell growth [PMID:15689497]
experiment: EXISTENCE:genetic interaction:GO:0016197 endosomal transport [PMID:21451250]
experiment: EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:15372071]
experiment: EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:15689497]
experiment: EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:21451250]
experiment: EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22307609]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:15689497]
experiment: EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15689497]
experiment: EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:15689497]
note: Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol 4,5-bisphosphate-binding protein
translation: MSYQRNSARASLDLRSQYQQLEGRMRSEHFNPAYQQQQQKGQNIPLSLPSSLAQRNPIPYPIDAVTSDPTIPAQLNVYDHDRQNSIVDAAAGTNTTHSLNSNNIPSSQNNNINNNNINNVGSFTDPSMLTLPKMSLHSHQKQYDSNQNDPRSPLAILIPTSAQPTDVLSARFSAWRNVIRAILVYLSETASIQDEIVRQQLRLSHAVQFPFFSIENQYQPVSNEDKSMQKFFLPLGSGSVQDLPTMLTKYHDNLASLASKSSKELTSEIIPRLEDLRRDLLVKIKEIKALQSDFKNSCNKELQQTKHLMKLFNESLKECKLGTPKSDPFLIKLQLEKQIKRQLVEENYLHEAFDNLQNSGAQLESVIVMEIQNGLTSYARILGKEAQVVFDSVISKLDSTILNKNTNLEWDSFILRNISNFVPPNLPMRRFKEISYSNQNDPFTFEVKSGFLEKRSKFLKSYSRGFYVLTPSFLHEFKTPDKHKFSTPLMSIPLVECTVTEHSKKTKSNSEQGKNKFILRTNSNGLIHRGHNWVFKVDSYDDMIEWFGNIKALSSLPNYDDKCKYVSKVAKLSKEKAKSNENTTESVTPQVTNEQHTRYDDVSSSNFPLNSIPKLDNLTITNTTSSIPETNDSQIQNRVPEFYIENVDSPRKSNQL
SIO_010081: YNL047C
subclass of: SO_0000673
so part of: YNL047C
location: complement(539911..541881)
location: region:539911-541881:-1
so has part: feature:539911-541881:-1:exon

NP_014351.3
type: Protein
SIO_000068: ncbiprotein

S000004992
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:539911-541881:-1:exon

YNL046W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL046W
so part of: sequence
location: <542304..>542822
location: region:542304-542822:1
so has part: feature:542304-542822:1:exon
subclass of: SO_0000010

855681
type: Gene
SIO_000068: ncbigene

position:542304:1
position: 542304
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:542822:1
position: 542822
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542304-542822:1:exon

YNL046W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL046W
product: uncharacterized protein
transcript id: NM_001182885.3
SIO_010081: YNL046W
subclass of: SO_0000673
so part of: YNL046W
location: <542304..>542822
location: region:542304-542822:1
so has part: feature:542304-542822:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:542304-542822:1:exon

YNL046W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL046W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
note: hypothetical protein; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
codon start: 1
product: uncharacterized protein
translation: MEHVSKRSIGQFFKRKTSTVDGSKSQKCGTTNQLRKLLHKRRVQKQAVPVESQYRIPGDFRDNQSVRVKNSMYNSSPSVTPSTHHINERYVRYDINTRPLVVVLAISIVFFGCLLVLKDIIIQSSENILSVSKWKIIGASFMGTPYTGLLTGLVGPLLSPFSAVSSWLSFIF
SIO_010081: YNL046W
subclass of: SO_0000673
so part of: YNL046W
location: 542304..542822
location: region:542304-542822:1
so has part: feature:542304-542822:1:exon

NP_014352.3
type: Protein
SIO_000068: ncbiprotein

S000004991
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:542304-542822:1:exon

YNL045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LAP2
locus tag: YNL045W
so part of: sequence
location: <542963..>544978
location: region:542963-544978:1
so has part: feature:542963-544978:1:exon
subclass of: SO_0000010

855682
type: Gene
SIO_000068: ncbigene

position:542963:1
position: 542963
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:544978:1
position: 544978
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542963-544978:1:exon

YNL045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LAP2
locus tag: YNL045W
product: bifunctional aminopeptidase/epoxide hydrolase
transcript id: NM_001182884.1
SIO_010081: YNL045W
subclass of: SO_0000673
so part of: YNL045W
location: <542963..>544978
location: region:542963-544978:1
so has part: feature:542963-544978:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:542963-544978:1:exon

YNL045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LAP2
locus tag: YNL045W
EC number: 3.3.2.10
experiment: EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:10574934]
experiment: EXISTENCE:direct assay:GO:0004301 epoxide hydrolase activity [PMID:10574934]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:10574934]
experiment: EXISTENCE:direct assay:GO:0044255 cellular lipid metabolic process [PMID:10574934]
note: Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase
codon start: 1
product: bifunctional aminopeptidase/epoxide hydrolase
translation: MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSKDTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLGL
SIO_010081: YNL045W
subclass of: SO_0000673
so part of: YNL045W
location: 542963..544978
location: region:542963-544978:1
so has part: feature:542963-544978:1:exon

NP_014353.1
type: Protein
SIO_000068: ncbiprotein

S000004990
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:542963-544978:1:exon

YNL044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YIP3
locus tag: YNL044W
so part of: sequence
location: <545268..>545877
location: region:545268-545877:1
so has part: feature:545268-545877:1:exon
subclass of: SO_0000010

855683
type: Gene
SIO_000068: ncbigene

position:545268:1
position: 545268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:545877:1
position: 545877
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545268-545877:1:exon

YNL044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YIP3
locus tag: YNL044W
product: Yip3p
transcript id: NM_001182883.1
SIO_010081: YNL044W
subclass of: SO_0000673
so part of: YNL044W
location: join(<545268..545291,545371..>545877)
location: region:545268-545877:1
so has part: feature:545268-545291:1:exon
so has part: feature:545371-545877:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:545268-545291:1:exon

position:545291:1
position: 545291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:545371-545877:1:exon

position:545371:1
position: 545371
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YIP3
locus tag: YNL044W
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16002643]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16002643]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]
note: Protein localized to COPII vesicles; proposed to be involved in ER-to-Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; integral membrane protein that localizes to the ER, the Golgi apparatus, transport vesicles and the peroxisome; two isoforms exist, a full-length Yip3L (Yip3 Long) and a shorter peroxisomal matrix isoform Yip3S (Yip3 Short)
codon start: 1
product: Yip3p
translation: MNQLGALAQVSRFTQNFSMENIKSEFQSLQSKLATLRTPQEFFNFKKISKPQNFGEVQSRVAYNLKYFSSNYGLIIGCLSIYTLLTNLLLLFVIVLVVAGIVGINKLKGEELVTPFGSFKTNQLYTGLVCVAVPIGFLASPISTLLWLIGASAVSVFGHASLMEKPIETVFDEETV
SIO_010081: YNL044W
subclass of: SO_0000673
so part of: YNL044W
location: join(545268..545291,545371..545877)
location: region:545268-545877:1
so has part: feature:545268-545291:1:exon
so has part: feature:545371-545877:1:exon

NP_014354.2
type: Protein
SIO_000068: ncbiprotein

S000004989
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545268-545291:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:545371-545877:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1421; Autonomously Replicating Sequence
so part of: sequence
location: 546072..546170
location: region:546072-546170:1
so has part: feature:546072-546170:1:region

S000118389
type: SGD
SIO_000068: sgd

position:546072:1
position: 546072
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:546170:1
position: 546170
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546072-546170:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 546423..546714
location: region:546423-546714:1
so has part: feature:546423-546714:1:region

S000007138
type: SGD
SIO_000068: sgd

position:546423:1
position: 546423
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:546714:1
position: 546714
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546423-546714:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 546738..547077
location: region:546738-547077:1
so has part: feature:546738-547077:1:region

S000007139
type: SGD
SIO_000068: sgd

position:546738:1
position: 546738
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:547077:1
position: 547077
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546738-547077:1:region

YNCN0009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0009W
so part of: sequence
location: 547094..547196
location: region:547094-547196:1
so has part: feature:547094-547196:1:exon
subclass of: SO_0000663

855685
type: Gene
SIO_000068: ncbigene

position:547094:1
position: 547094
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:547196:1
position: 547196
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547094-547196:1:exon

YNCN0009W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0009W
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin
SIO_010081: YNCN0009W
subclass of: SO_0000673
so part of: YNCN0009W
location: join(547094..547129,547161..547196)
location: region:547094-547196:1
so has part: feature:547094-547129:1:exon
so has part: feature:547161-547196:1:exon

S000006685
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547094-547129:1:exon

position:547129:1
position: 547129
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:547161-547196:1:exon

position:547161:1
position: 547161
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL042W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL042W-B
so part of: sequence
location: <547113..>547370
location: region:547113-547370:1
so has part: feature:547113-547370:1:exon
subclass of: SO_0000010

1466515
type: Gene
SIO_000068: ncbigene

position:547113:1
position: 547113
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547370:1
position: 547370
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547113-547370:1:exon

YNL042W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL042W-B
product: uncharacterized protein
transcript id: NM_001184662.3
SIO_010081: YNL042W-B
subclass of: SO_0000673
so part of: YNL042W-B
location: <547113..>547370
location: region:547113-547370:1
so has part: feature:547113-547370:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:547113-547370:1:exon

YNL042W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL042W-B
codon start: 1
product: uncharacterized protein
translation: MILALGDFLPKQEDKACERPWVQFPARPVIFFHHQGGIFLFSINQPNLSCFSKLKEVNSLYVRVATYICQKNESRFRTNRLKGDQ
SIO_010081: YNL042W-B
subclass of: SO_0000673
so part of: YNL042W-B
location: 547113..547370
location: region:547113-547370:1
so has part: feature:547113-547370:1:exon

NP_878157.3
type: Protein
SIO_000068: ncbiprotein

S000028850
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547113-547370:1:exon

YNL042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BOP3
locus tag: YNL042W
so part of: sequence
location: <548100..>549290
location: region:548100-549290:1
so has part: feature:548100-549290:1:exon
subclass of: SO_0000010

855686
type: Gene
SIO_000068: ncbigene

position:548100:1
position: 548100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549290:1
position: 549290
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548100-549290:1:exon

YNL042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BOP3
locus tag: YNL042W
product: Bop3p
transcript id: NM_001182881.1
SIO_010081: YNL042W
subclass of: SO_0000673
so part of: YNL042W
location: <548100..>549290
location: region:548100-549290:1
so has part: feature:548100-549290:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548100-549290:1:exon

YNL042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BOP3
locus tag: YNL042W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:15796894]
note: hypothetical protein; potential Cdc28p substrate; overproduction confers resistance to methylmercury
codon start: 1
product: Bop3p
translation: MSTFNSYSQPKESNDNSHNNVNKSKSLLDIIFGTNVSEWAFSENALMKAMDLKIEQEKTKQQYYKLENLNRSIELFKLASSSGLPINQIHKLFNTDHGVPASSPMKAGGNQPHNNTEGTQSSENLPRLNGSMKSLKPLNMNTVSPTPMSRQPSPYKFPASSSTGGISHSTVTNVQRRANSPARIGASAVAALNDNISIKEEDVARRIPSGTKSQESPLNKKPTSLHSRNLSLPIGKFTNPNIPSTMTSILSFNRDQQQPLSQPLPPPPQQQQDLHTHNLHTIPRKPGMVQKKHRRARSTSSFGVIDLSIIDEAKEKQVQRSPSPIHSNVSVALTSHDKPIESNMKEQPNMLQSVREGRQVHDDLDDRTCSESSSRNESPVRTITKDNSVGKILNST
SIO_010081: YNL042W
subclass of: SO_0000673
so part of: YNL042W
location: 548100..549290
location: region:548100-549290:1
so has part: feature:548100-549290:1:exon

NP_014356.1
type: Protein
SIO_000068: ncbiprotein

S000004987
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548100-549290:1:exon

YNL041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COD2
alternative label: SEC37
gene: COG6
locus tag: YNL041C
gene synonym: COD2; SEC37
so part of: sequence
location: complement(<549468..>551987)
location: region:549468-551987:-1
so has part: feature:549468-551987:-1:exon
subclass of: SO_0000010

855687
type: Gene
SIO_000068: ncbigene

position:549468:-1
position: 549468
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551987:-1
position: 551987
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549468-551987:-1:exon

YNL041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COD2
alternative label: SEC37
gene: COG6
locus tag: YNL041C
gene synonym: COD2; SEC37
product: Golgi transport complex subunit COG6
transcript id: NM_001182880.1
SIO_010081: YNL041C
subclass of: SO_0000673
so part of: YNL041C
location: complement(<549468..>551987)
location: region:549468-551987:-1
so has part: feature:549468-551987:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549468-551987:-1:exon

YNL041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COD2
alternative label: SEC37
gene: COG6
locus tag: YNL041C
gene synonym: COD2; SEC37
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
note: Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG6
translation: MDFVVDYQTYAMADTATPELPEPEPRLNLTSDAQSQPTGKLDLQFKLPDLQRYSNNNATLPVDNDGAGSKDLHKKMTHYAMSSIDKIQLSNPSKQLGQNSQDEKLSQQESQNFTNYEPKNLDLSKLVSPSSGSNKNTTNLVLSNKLSKILNNYTLINYQATVQLRKSLKVLEENKERLSLDEQKLMNPEYVGTLARRALRTDLESQLLKEHITVLEEFKPIIRRIKRLSSSVEKIQRTSEKLLSNETNEVPTNNVVLQEIDQYRLKAEQLKLKKKILLSIRDRFTLNQVEDDVITNGTIDNIFFEVVKKVINIKDESSFLLTLPNLNAGNALIMGVNEILEKTNKKIFNYLIDFLYSFESSSNLLNDHGTTEQESLNIFRKSLVFLSSDLELFNELLKRVTTLRSKSILDEFLSQFDMNSTTSKPIILSAHDPIRYIGDVLASVHSIIANEADFVKSLFDFQDEDLKDTPISILQQNKTFLKGIDNKLLNDIIQSLSNSCRIRIEQIVRFEENPIINFEIVRLLKLYRVMFERKGIQDDSSIINNLKSLEDISKNRIIGYYEDYMKQTVMAETKNSSDDLLPPEWLSEYMNKLVELFEIYEKTHAAEDEESEDNKLLSSKNLQTIVEQPIKDVLLKQLQTSFPLAKKNEKEKASLLTIEINCFDLIKSRLQPFEGLFAQDDDSRKITIWVCDKLKEYTKQMLTLQIKFLFENTGLDLYSNLVNMIFPVDSVKDELDYDMYLALRDNSLMELDMVRKNVHDKLNYYLPQALTDVQGNLLFKLTSPMIADEICDECFKKLSLFYNIFRKLLIHLYPNKKDQVFEILNFSTDEFDMLIGIDH
SIO_010081: YNL041C
subclass of: SO_0000673
so part of: YNL041C
location: complement(549468..551987)
location: region:549468-551987:-1
so has part: feature:549468-551987:-1:exon

NP_014357.1
type: Protein
SIO_000068: ncbiprotein

S000004986
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549468-551987:-1:exon

YNL040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL040W
so part of: sequence
location: <553380..>554750
location: region:553380-554750:1
so has part: feature:553380-554750:1:exon
subclass of: SO_0000010

855688
type: Gene
SIO_000068: ncbigene

position:553380:1
position: 553380
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:554750:1
position: 554750
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553380-554750:1:exon

YNL040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL040W
product: putative alanine--tRNA ligase
transcript id: NM_001182879.3
SIO_010081: YNL040W
subclass of: SO_0000673
so part of: YNL040W
location: <553380..>554750
location: region:553380-554750:1
so has part: feature:553380-554750:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:553380-554750:1:exon

YNL040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL040W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
note: hypothetical protein; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene
codon start: 1
product: putative alanine--tRNA ligase
translation: MPTPMTPVKVGALACQRNSFLFDGFKTLVVSCEPTKNKKGEIEGYEIELQDTILFPEGGGQPSDSGFLKIVEGNRNSSKIEKILVSHVSRFGLHAKHHVNDYIEPGTTVEVAVDEQKRMDYMQQHTGQHLLSAILERNYKVDTVSWSMGGIITKKKPVLEPSDYFNYIELNRKLTLDEITNVSDEINQLIINFPQEIIVEERIGEETVDEVSTSKIPDDYDLSKGVLRTIHIGDIDSNPCCGTHLKCTSQIGSILILSNQSAVRGSNSRLYFMCGKRVSLYAKSVNKILLDSKNLLSCSETQISEKITRQTKQIQQLNKREQYWIKRLARTASEELMNTLKASGKKRAYFMEEEYGTLELLLQIHKEVSNFLKDDTEGYEIILCGYERQTNTGSLLILSESGEKIANLAANLGSILQNLKGGGGKKGGKWQGKITSISNAEFAALSDYLSHDFASC
SIO_010081: YNL040W
subclass of: SO_0000673
so part of: YNL040W
location: 553380..554750
location: region:553380-554750:1
so has part: feature:553380-554750:1:exon

NP_014358.3
type: Protein
SIO_000068: ncbiprotein

S000004985
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:553380-554750:1:exon

YNL039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TFC5
alternative label: TFC7
gene: BDP1
locus tag: YNL039W
gene synonym: TFC5; TFC7
so part of: sequence
location: <555048..>556832
location: region:555048-556832:1
so has part: feature:555048-556832:1:exon
subclass of: SO_0000010

855689
type: Gene
SIO_000068: ncbigene

position:555048:1
position: 555048
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556832:1
position: 556832
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:555048-556832:1:exon

YNL039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TFC5
alternative label: TFC7
gene: BDP1
locus tag: YNL039W
gene synonym: TFC5; TFC7
product: transcription factor TFIIIB subunit BDP1
transcript id: NM_001182878.3
SIO_010081: YNL039W
subclass of: SO_0000673
so part of: YNL039W
location: <555048..>556832
location: region:555048-556832:1
so has part: feature:555048-556832:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:555048-556832:1:exon

YNL039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TFC5
alternative label: TFC7
gene: BDP1
locus tag: YNL039W
gene synonym: TFC5; TFC7
experiment: EXISTENCE:curator inference:GO:0000995 RNA polymerase III general transcription initiation factor activity [PMID:11387215|PMID:12930823|PMID:1458536]
experiment: EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:7568218|PMID:1458536]
experiment: EXISTENCE:direct assay:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]
experiment: EXISTENCE:direct assay:GO:0070896 positive regulation of transposon integration [PMID:10882723]
experiment: EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]
experiment: EXISTENCE:mutant phenotype:GO:0001112 DNA-templated transcription open complex formation [PMID:11387215]
experiment: EXISTENCE:mutant phenotype:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]
experiment: EXISTENCE:physical interaction:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]
note: Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
codon start: 1
product: transcription factor TFIIIB subunit BDP1
translation: MSSIVNKSGTRFAPKVRQRRAATGGTPTPKPRTPQLFIPESKEIEEDNSDNDKGVDENETAIVEKPSLVGERSLEGFTLTGTNGHDNEIGDEGPIDASTQNPKADVIEDNVTLKPAPLQTHRDQKVPRSSRLASLSKDNESRPSFKPSFLDSSSNSNGTARRLSTISNKLPKKIRLGSITENDMNLKTFKRHRVLGKPSSAKKPAGAHRISIVSKISPPTAMTDSLDRNEFSSETSTSREADENENYVISKVKDIPKKVRDGESAKYFIDEENFTMAELCKPNFPIGQISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEEEEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFYKALSMWGTDFNLISQLYPYRSRKQVKAKFVNEEKKRPILIELALRSKLPPNFDEYCCEIKKNIGTVADFNEKLIELQNEHKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLKVYRKTEVVLGTIDDLKRKKLKERNNDDNEDNEGSEEEPEIDQ
SIO_010081: YNL039W
subclass of: SO_0000673
so part of: YNL039W
location: 555048..556832
location: region:555048-556832:1
so has part: feature:555048-556832:1:exon

NP_014359.3
type: Protein
SIO_000068: ncbiprotein

S000004984
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:555048-556832:1:exon

YNL038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPI15
locus tag: YNL038W
so part of: sequence
location: <557020..>557783
location: region:557020-557783:1
so has part: feature:557020-557783:1:exon
subclass of: SO_0000010

855690
type: Gene
SIO_000068: ncbigene

position:557020:1
position: 557020
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:557783:1
position: 557783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557020-557783:1:exon

YNL038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPI15
locus tag: YNL038W
product: phosphatidylinositol N-acetylglucosaminyltransferase GPI15
transcript id: NM_001182877.1
SIO_010081: YNL038W
subclass of: SO_0000673
so part of: YNL038W
location: join(<557020..557610,557685..>557783)
location: region:557020-557783:1
so has part: feature:557020-557610:1:exon
so has part: feature:557685-557783:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557020-557610:1:exon

position:557610:1
position: 557610
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:557685-557783:1:exon

position:557685:1
position: 557685
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPI15
locus tag: YNL038W
EC number: 2.4.1.198
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:11746600]
experiment: EXISTENCE:mutant phenotype:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:11746600]
note: Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol
codon start: 1
product: phosphatidylinositol N-acetylglucosaminyltransferase GPI15
translation: MISKEYEFGKTSILNRKKYTLVIDEDKNGNFIRFTVLPVSNRKFKKVKQNGRVEINMGIQYHQIVLILLLNILFYVICLRSRFLEHINRTFEVTIARSFQILIIMGLFALGTIILVRGPSVETVTIFKESGLQLSRVKGMVIFPQQWNRKFFEQVEFISNERIIDVVINEGFCRGFRVIFYLAAIVRKSSTLKLLFPSNLPSIDDQRLIYNISRKYLSKQEKPLSRPKD
SIO_010081: YNL038W
subclass of: SO_0000673
so part of: YNL038W
location: join(557020..557610,557685..557783)
location: region:557020-557783:1
so has part: feature:557020-557610:1:exon
so has part: feature:557685-557783:1:exon

NP_014360.2
type: Protein
SIO_000068: ncbiprotein

S000004983
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557020-557610:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:557685-557783:1:exon

YNL037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IDH1
locus tag: YNL037C
so part of: sequence
location: complement(<557920..>559002)
location: region:557920-559002:-1
so has part: feature:557920-559002:-1:exon
subclass of: SO_0000010

855691
type: Gene
SIO_000068: ncbigene

position:557920:-1
position: 557920
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:559002:-1
position: 559002
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557920-559002:-1:exon

YNL037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IDH1
locus tag: YNL037C
product: isocitrate dehydrogenase (NAD(+)) IDH1
transcript id: NM_001182876.1
SIO_010081: YNL037C
subclass of: SO_0000673
so part of: YNL037C
location: complement(<557920..>559002)
location: region:557920-559002:-1
so has part: feature:557920-559002:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557920-559002:-1:exon

YNL037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IDH1
locus tag: YNL037C
EC number: 1.1.1.41
experiment: EXISTENCE:direct assay:GO:0004449 isocitrate dehydrogenase (NAD+) activity [PMID:16884682]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8626605]
experiment: EXISTENCE:direct assay:GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+) [PMID:16884682]
experiment: EXISTENCE:direct assay:GO:0006102 isocitrate metabolic process [PMID:16884682]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]
note: Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
codon start: 1
product: isocitrate dehydrogenase (NAD(+)) IDH1
translation: MLNRTIAKRTLATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM
SIO_010081: YNL037C
subclass of: SO_0000673
so part of: YNL037C
location: complement(557920..559002)
location: region:557920-559002:-1
so has part: feature:557920-559002:-1:exon

NP_014361.1
type: Protein
SIO_000068: ncbiprotein

S000004982
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557920-559002:-1:exon

YNL036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NCE3
gene: NCE103
locus tag: YNL036W
gene synonym: NCE3
so part of: sequence
location: <559814..>560479
location: region:559814-560479:1
so has part: feature:559814-560479:1:exon
subclass of: SO_0000010

855692
type: Gene
SIO_000068: ncbigene

position:559814:1
position: 559814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560479:1
position: 560479
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559814-560479:1:exon

YNL036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NCE3
gene: NCE103
locus tag: YNL036W
gene synonym: NCE3
product: carbonate dehydratase NCE103
transcript id: NM_001182875.3
SIO_010081: YNL036W
subclass of: SO_0000673
so part of: YNL036W
location: <559814..>560479
location: region:559814-560479:1
so has part: feature:559814-560479:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559814-560479:1:exon

YNL036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NCE3
gene: NCE103
locus tag: YNL036W
gene synonym: NCE3
EC number: 4.2.1.1
experiment: EXISTENCE:direct assay:GO:0004089 carbonate dehydratase activity [PMID:15096093|PMID:15813743]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15096093]
experiment: EXISTENCE:mutant phenotype:GO:0071244 cellular response to carbon dioxide [PMID:22253597]
note: Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress
codon start: 1
product: carbonate dehydratase NCE103
translation: MSATESSSIFTLSHNSNLQDILAANAKWASQMNNIQPTLFPDHNAKGQSPHTLFIGCSDSRYNENCLGVLPGEVFTWKNVANICHSEDLTLKATLEFAIICLKVNKVIICGHTDCGGIKTCLTNQREALPKVNCSHLYKYLDDIDTMYHEESQNLIHLKTQREKSHYLSHCNVKRQFNRIIENPTVQTAVQNGELQVYGLLYNVEDGLLQTVSTYTKVTPK
SIO_010081: YNL036W
subclass of: SO_0000673
so part of: YNL036W
location: 559814..560479
location: region:559814-560479:1
so has part: feature:559814-560479:1:exon

NP_014362.3
type: Protein
SIO_000068: ncbiprotein

S000004981
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559814-560479:1:exon

YNCN0010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0010C
so part of: sequence
location: complement(560693..560765)
location: region:560693-560765:-1
so has part: feature:560693-560765:-1:exon
subclass of: SO_0000663

855693
type: Gene
SIO_000068: ncbigene

position:560693:-1
position: 560693
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:560765:-1
position: 560765
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560693-560765:-1:exon

YNCN0010C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0010C
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0010C
subclass of: SO_0000673
so part of: YNCN0010C
location: complement(560693..560765)
location: region:560693-560765:-1
so has part: feature:560693-560765:-1:exon

S000006745
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560693-560765:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1422; Autonomously Replicating Sequence
so part of: sequence
location: 561111..561388
location: region:561111-561388:1
so has part: feature:561111-561388:1:region

S000118390
type: SGD
SIO_000068: sgd

position:561111:1
position: 561111
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:561388:1
position: 561388
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561111-561388:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 561607..561977
location: region:561607-561977:1
so has part: feature:561607-561977:1:region

S000007141
type: SGD
SIO_000068: sgd

position:561607:1
position: 561607
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:561977:1
position: 561977
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561607-561977:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(562033..562364)
location: region:562033-562364:-1
so has part: feature:562033-562364:-1:region

S000007131
type: SGD
SIO_000068: sgd

position:562033:-1
position: 562033
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:562364:-1
position: 562364
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:562033-562364:-1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YNLCTy2-1; Ty2 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats; mutated in S288C
mobile element type: retrotransposon:YNLCTy2-1
so part of: sequence
location: complement(562364..567660)
location: region:562364-567660:-1
so has part: feature:562364-567660:-1:region

S000007135
type: SGD
SIO_000068: sgd

position:567660:-1
position: 567660
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:562364-567660:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(567660..567992)
location: region:567660-567992:-1
so has part: feature:567660-567992:-1:region

S000007132
type: SGD
SIO_000068: sgd

position:567992:-1
position: 567992
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:567660-567992:-1:region

YNCN0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0011W
so part of: sequence
location: 568115..568217
location: region:568115-568217:1
so has part: feature:568115-568217:1:exon
subclass of: SO_0000663

855694
type: Gene
SIO_000068: ncbigene

position:568115:1
position: 568115
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:568217:1
position: 568217
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568115-568217:1:exon

YNCN0011W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0011W
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin
SIO_010081: YNCN0011W
subclass of: SO_0000673
so part of: YNCN0011W
location: join(568115..568150,568182..568217)
location: region:568115-568217:1
so has part: feature:568115-568150:1:exon
so has part: feature:568182-568217:1:exon

S000006686
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568115-568150:1:exon

position:568150:1
position: 568150
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:568182-568217:1:exon

position:568182:1
position: 568182
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1423; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 568219..568524
location: region:568219-568524:1
so has part: feature:568219-568524:1:region

S000130143
type: SGD
SIO_000068: sgd

position:568219:1
position: 568219
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:568524:1
position: 568524
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568219-568524:1:region

YNL035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL035C
so part of: sequence
location: complement(<568522..>569691)
location: region:568522-569691:-1
so has part: feature:568522-569691:-1:exon
subclass of: SO_0000010

855695
type: Gene
SIO_000068: ncbigene

position:568522:-1
position: 568522
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:569691:-1
position: 569691
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568522-569691:-1:exon

YNL035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL035C
product: uncharacterized protein
transcript id: NM_001182874.1
SIO_010081: YNL035C
subclass of: SO_0000673
so part of: YNL035C
location: complement(<568522..>569691)
location: region:568522-569691:-1
so has part: feature:568522-569691:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:568522-569691:-1:exon

YNL035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL035C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
note: Nuclear hypothetical protein; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MASYSLVESNSFGSENWCLKLQPSYKHGLLTGLSNGEIRLLDWSTGKSVQKIKASETAINDMKVIGSDFSAGHLVSSASIDAVKVFDIRTNDRIAQIQNEANSPFISLDSRHGLLACGTELQGIDAAVYIYDIRKWDTPLRSLIDSHHDDVTCIKFHPSDVNILLSGSTDGYTNIYDLKQDEEEDALHQVINYASIHSCGWLSPKRIFTLSHMETFAIHELNDKSDELKEPQPLDFGDVREIWNCDYVVDIYPGLIATGKTQENCGELCLLPFKDEKVDTENGIVIPHAHGDEVVRDIFIPAQHSNMLYSCGEDGCVKIWENKQGPLDIPENFWDYSKKMNVLGDDDREGSINLDEPLIIQKESVSTRPRKEKHKKAKKHSMKSRFKPY
SIO_010081: YNL035C
subclass of: SO_0000673
so part of: YNL035C
location: complement(568522..569691)
location: region:568522-569691:-1
so has part: feature:568522-569691:-1:exon

NP_014363.1
type: Protein
SIO_000068: ncbiprotein

S000004980
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568522-569691:-1:exon

YNCN0012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0012C
so part of: sequence
location: complement(569867..569940)
location: region:569867-569940:-1
so has part: feature:569867-569940:-1:exon
subclass of: SO_0000663

855696
type: Gene
SIO_000068: ncbigene

position:569867:-1
position: 569867
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:569940:-1
position: 569940
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569867-569940:-1:exon

YNCN0012C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0012C
product: tRNA-Ile
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0012C
subclass of: SO_0000673
so part of: YNCN0012C
location: complement(569867..569940)
location: region:569867-569940:-1
so has part: feature:569867-569940:-1:exon

S000006609
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:569867-569940:-1:exon

YNL034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL034W
so part of: sequence
location: <570477..>572315
location: region:570477-572315:1
so has part: feature:570477-572315:1:exon
subclass of: SO_0000010

855697
type: Gene
SIO_000068: ncbigene

position:570477:1
position: 570477
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:572315:1
position: 572315
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:570477-572315:1:exon

YNL034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL034W
product: uncharacterized protein
transcript id: NM_001182873.1
SIO_010081: YNL034W
subclass of: SO_0000673
so part of: YNL034W
location: <570477..>572315
location: region:570477-572315:1
so has part: feature:570477-572315:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:570477-572315:1:exon

YNL034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL034W
note: Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MSTSFQEFKAFCNKVGLDFQWLNLQSSKSVPESGSSEGFSAVSDTVQENIRPATEPLNVNQSKDPVSNFFYDVKNAPLWNVYKRNHSGHSSTEACSGVSSGQASKNIPEAMVKETVLSNHDNVTIINELLPTSSAMHQEESTAMTTSYLLSHSVNDSCNVMLSSSSHNRAMLPPSLVQRNNATTSPTTDSASENNESVPSLTSSVSTSSSVYSSWNPPHSPHISSFPDGNFASLNAEVTCFDFRRTKDSRTKETNESIIPTEIYCPINSTDHHKHYPSQKSKQDACAPAPRNQNISCSVGSAAEFSQSNHTLTTVVPSYMQQYLDRPQNWFESKMGKYCPLFLRSTKNIDYDSLEFKFERKMIAVQYLLLDEQSEPRRYYNPSNKSIPFWKRPFNFDTMPSYDQLMEEAECRFYSYQYKYEGFQRIEPYSIFCPWKNTQREIDLVLDHIHFSLDVGEKKSLNRKGNITLDTLDSKVDPNIQIKPYQIFPSNNLVYEGLPHPAEQSLILSPGTSLIERAFQALIDICKESIPPSNDCTTRNHNSAPQLTVPEPSKPCRLLLVRESRTATELETNKKLWLHSQRRNIEVTVPMHPSEHGTKSRLRKWLSTFVHQ
SIO_010081: YNL034W
subclass of: SO_0000673
so part of: YNL034W
location: 570477..572315
location: region:570477-572315:1
so has part: feature:570477-572315:1:exon

NP_014364.1
type: Protein
SIO_000068: ncbiprotein

S000004979
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:570477-572315:1:exon

YNL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL033W
so part of: sequence
location: <572999..>573853
location: region:572999-573853:1
so has part: feature:572999-573853:1:exon
subclass of: SO_0000010

855698
type: Gene
SIO_000068: ncbigene

position:572999:1
position: 572999
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573853:1
position: 573853
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:572999-573853:1:exon

YNL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL033W
product: uncharacterized protein
transcript id: NM_001182872.3
SIO_010081: YNL033W
subclass of: SO_0000673
so part of: YNL033W
location: <572999..>573853
location: region:572999-573853:1
so has part: feature:572999-573853:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:572999-573853:1:exon

YNL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL033W
note: hypothetical protein; YNL033W has a paralog, YNL019C, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MLYSRESRTTVLFLALVTSLTVLCHSVDVTTVFTTSTITEITTVTAAPQPQNKAETALNTATNIIQTMQFLFNCAPFKWKGPLKITSCALNFIVLLLTAWGYLLKYLQENKLNSDADMEKMVGLGFGEMVGRIFGKGVGKAFTKMDITQKLVYPFEGSNRQKCLLMTVGENSIVPFHDLFTEICFDQYTLDSLSHHNHGSISILDAGSVSALGFADISSKMPSVSELYTLFGDYTIEVLGGITKLASTLNREDWQGERNGFAVLSRDRPNQTLLSVHMYSSSLL
SIO_010081: YNL033W
subclass of: SO_0000673
so part of: YNL033W
location: 572999..573853
location: region:572999-573853:1
so has part: feature:572999-573853:1:exon

NP_014365.3
type: Protein
SIO_000068: ncbiprotein

S000004978
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:572999-573853:1:exon

YNL032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OCA3
gene: SIW14
locus tag: YNL032W
gene synonym: OCA3
so part of: sequence
location: <574506..>575351
location: region:574506-575351:1
so has part: feature:574506-575351:1:exon
subclass of: SO_0000010

855699
type: Gene
SIO_000068: ncbigene

position:574506:1
position: 574506
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:575351:1
position: 575351
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574506-575351:1:exon

YNL032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OCA3
gene: SIW14
locus tag: YNL032W
gene synonym: OCA3
product: putative tyrosine protein phosphatase SIW14
transcript id: NM_001182871.3
SIO_010081: YNL032W
subclass of: SO_0000673
so part of: YNL032W
location: <574506..>575351
location: region:574506-575351:1
so has part: feature:574506-575351:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574506-575351:1:exon

YNL032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OCA3
gene: SIW14
locus tag: YNL032W
gene synonym: OCA3
EC number: 3.6.1.52
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:26828065|PMID:29540476]
experiment: EXISTENCE:direct assay:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]
experiment: EXISTENCE:direct assay:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:15020461]
experiment: EXISTENCE:mutant phenotype:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:26828065|PMID:29540476]
experiment: EXISTENCE:mutant phenotype:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]
experiment: EXISTENCE:mutant phenotype:GO:0071543 diphosphoinositol polyphosphate metabolic process [PMID:26828065]
experiment: EXISTENCE:mutant phenotype:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]
note: Inositol phosphatase involved in inositol pyrophosphate metabolism; hydrolyzes the beta-phosphate from the 5-diphosphate group of PP-InsPs including: 5PP-IP5 (IP7), 1,5PP-IP4 (IP8) and 5-PP-InsP4; functions as an anti-prion (anti-[PSI]) component; member of the atypical dual-specificity subgroup of the protein tyrosine-phosphatase (PTP) superfamily; localizes to the cytoplasm
codon start: 1
product: putative tyrosine protein phosphatase SIW14
translation: MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDNGDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTIEVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEYPQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGKHRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNWLPLQW
SIO_010081: YNL032W
subclass of: SO_0000673
so part of: YNL032W
location: 574506..575351
location: region:574506-575351:1
so has part: feature:574506-575351:1:exon

NP_014366.3
type: Protein
SIO_000068: ncbiprotein

S000004977
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574506-575351:1:exon

YNL031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HHT2
locus tag: YNL031C
so part of: sequence
location: complement(<575640..>576050)
location: region:575640-576050:-1
so has part: feature:575640-576050:-1:exon
subclass of: SO_0000010

855700
type: Gene
SIO_000068: ncbigene

position:575640:-1
position: 575640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:576050:-1
position: 576050
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575640-576050:-1:exon

YNL031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HHT2
locus tag: YNL031C
product: histone H3
transcript id: NM_001182870.1
SIO_010081: YNL031C
subclass of: SO_0000673
so part of: YNL031C
location: complement(<575640..>576050)
location: region:575640-576050:-1
so has part: feature:575640-576050:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:575640-576050:-1:exon

YNL031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HHT2
locus tag: YNL031C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0008823 cupric reductase activity [PMID:32631887]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0043505 CENP-A containing nucleosome [PMID:22693454]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:32631887]
experiment: EXISTENCE:mutant phenotype:GO:0008823 cupric reductase activity [PMID:32631887]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:32631887]
experiment: EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:16002464]
experiment: EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:20713519]
experiment: EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21460225]
note: Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage
codon start: 1
product: histone H3
translation: MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS
SIO_010081: YNL031C
subclass of: SO_0000673
so part of: YNL031C
location: complement(575640..576050)
location: region:575640-576050:-1
so has part: feature:575640-576050:-1:exon

NP_014367.1
type: Protein
SIO_000068: ncbiprotein

S000004976
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:575640-576050:-1:exon

YNL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HHF2
locus tag: YNL030W
so part of: sequence
location: <576727..>577038
location: region:576727-577038:1
so has part: feature:576727-577038:1:exon
subclass of: SO_0000010

855701
type: Gene
SIO_000068: ncbigene

position:576727:1
position: 576727
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:577038:1
position: 577038
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:576727-577038:1:exon

YNL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HHF2
locus tag: YNL030W
product: histone H4
transcript id: NM_001182869.1
SIO_010081: YNL030W
subclass of: SO_0000673
so part of: YNL030W
location: <576727..>577038
location: region:576727-577038:1
so has part: feature:576727-577038:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:576727-577038:1:exon

YNL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HHF2
locus tag: YNL030W
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
note: Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
codon start: 1
product: histone H4
translation: MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEEVRAVLKSFLESVIRDSVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG
SIO_010081: YNL030W
subclass of: SO_0000673
so part of: YNL030W
location: 576727..577038
location: region:576727-577038:1
so has part: feature:576727-577038:1:exon

NP_014368.1
type: Protein
SIO_000068: ncbiprotein

S000004975
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:576727-577038:1:exon

YNL029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KTR5
locus tag: YNL029C
so part of: sequence
location: complement(<577205..>578773)
location: region:577205-578773:-1
so has part: feature:577205-578773:-1:exon
subclass of: SO_0000010

855703
type: Gene
SIO_000068: ncbigene

position:577205:-1
position: 577205
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:578773:-1
position: 578773
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:577205-578773:-1:exon

YNL029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KTR5
locus tag: YNL029C
product: putative mannosyltransferase
transcript id: NM_001182868.3
SIO_010081: YNL029C
subclass of: SO_0000673
so part of: YNL029C
location: complement(<577205..>578773)
location: region:577205-578773:-1
so has part: feature:577205-578773:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:577205-578773:-1:exon

YNL029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KTR5
locus tag: YNL029C
experiment: EXISTENCE:curator inference:GO:0097502 mannosylation [PMID:9090056]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication
codon start: 1
product: putative mannosyltransferase
translation: MLLIRRTINAFLGCIHCNLTATCILIAFVITMYVVLVSEPASVDGTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVIKTINSIEEHFNQWFHYPYVFLNDQPFEEDFKAKVRDVTVGALVEFGTIDEISWNFPSDVKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFYKHPLVQKYEWYWRLEPDVEFFCDITYDPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQKGVTLGSLWKLFTKDYDIFESDDPELRDWINYDFQAKAKISEKIAIEQLLKKGDDFQQINDDKEGIMNLIHKARSRKHIVEDKFFNEEYNLCHFWSNFEIARLSVFDNDIYNSFFQYLEKSGGFWKERWGDAPVHSIGLSLTLDLDDVHYFRDIGYRHSTIQHCPHNAMGNEEFSYLASDSKFKRKNAAYDEGREFGCGCRCRCPKKKREIEDSMGFCVNIWVNLLNQQRGHERHVEALNGNEMEEHIREDYLRQFGN
SIO_010081: YNL029C
subclass of: SO_0000673
so part of: YNL029C
location: complement(577205..578773)
location: region:577205-578773:-1
so has part: feature:577205-578773:-1:exon

NP_014369.3
type: Protein
SIO_000068: ncbiprotein

S000004974
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:577205-578773:-1:exon

YNL027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HAL8
alternative label: TCN1
gene: CRZ1
locus tag: YNL027W
gene synonym: HAL8; TCN1
so part of: sequence
location: <579580..>581616
location: region:579580-581616:1
so has part: feature:579580-581616:1:exon
subclass of: SO_0000010

855704
type: Gene
SIO_000068: ncbigene

position:579580:1
position: 579580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:581616:1
position: 581616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579580-581616:1:exon

YNL027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HAL8
alternative label: TCN1
gene: CRZ1
locus tag: YNL027W
gene synonym: HAL8; TCN1
product: DNA-binding transcription factor CRZ1
transcript id: NM_001182866.1
SIO_010081: YNL027W
subclass of: SO_0000673
so part of: YNL027W
location: <579580..>581616
location: region:579580-581616:1
so has part: feature:579580-581616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579580-581616:1:exon

YNL027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HAL8
alternative label: TCN1
gene: CRZ1
locus tag: YNL027W
gene synonym: HAL8; TCN1
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:11523797]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11523797|PMID:20412803]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10197980]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10197980]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11523797|PMID:20412803]
experiment: EXISTENCE:direct assay:GO:0071483 cellular response to blue light [PMID:23335962]
experiment: EXISTENCE:genetic interaction:GO:0006038 cell wall chitin biosynthetic process [PMID:21343301]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:25258318|PMID:9407035]
experiment: EXISTENCE:genetic interaction:GO:0050801 ion homeostasis [PMID:9407035]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:15299026|PMID:9559673|PMID:9407035|PMI D:9407036|PMID:11523797]
experiment: EXISTENCE:mutant phenotype:GO:0050801 ion homeostasis [PMID:9407035]
experiment: EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:17056742]
note: Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium
codon start: 1
product: DNA-binding transcription factor CRZ1
translation: MSFSNGNMASYMTSSNGEEQSINNKNDIDDNSAYRRNNFRNSSNSGSHTFQLSDLDLDVDMRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSADLNYQSLYKPDLPQQQLQQQQLQQQQQQQQQQQQQQQKQTPTLKVEQSDTFQWDDILTPADNQHRPSLTNQFLSPRSNYDGTTRSSGIDSNYSDTESNYHTPYLYPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISNLDELDDLLSLTYSDNNLLSASNNSDFNNSNNGIINTADTQNSTIAINKSKVGTNQKMLLTIPTSSTPSPSTHAAPVTPIISIQEFNEGHFPVKNEDDGTLQLKVRDNESYSATNNNNLLRPDDNDYNNEALSDIDRSFEDIINGRKLKLKKSRRRSSQTSNNSFTSRRSSRSRSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDNDSKTSYNTINSSNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLGQFEQKVGFKNDDNHENNDNGTFSVKKNDNLEKLDSVTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFICSICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRRCITPLYEEARQEKSGQES
SIO_010081: YNL027W
subclass of: SO_0000673
so part of: YNL027W
location: 579580..581616
location: region:579580-581616:1
so has part: feature:579580-581616:1:exon

NP_014371.1
type: Protein
SIO_000068: ncbiprotein

S000004972
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579580-581616:1:exon

YNL026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OMP85
alternative label: TOB55
gene: SAM50
locus tag: YNL026W
gene synonym: OMP85; TOB55
so part of: sequence
location: <581920..>583374
location: region:581920-583374:1
so has part: feature:581920-583374:1:exon
subclass of: SO_0000010

855705
type: Gene
SIO_000068: ncbigene

position:581920:1
position: 581920
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583374:1
position: 583374
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581920-583374:1:exon

YNL026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OMP85
alternative label: TOB55
gene: SAM50
locus tag: YNL026W
gene synonym: OMP85; TOB55
product: SAM complex subunit SAM50
transcript id: NM_001182865.1
SIO_010081: YNL026W
subclass of: SO_0000673
so part of: YNL026W
location: <581920..>583374
location: region:581920-583374:1
so has part: feature:581920-583374:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:581920-583374:1:exon

YNL026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OMP85
alternative label: TOB55
gene: SAM50
locus tag: YNL026W
gene synonym: OMP85; TOB55
experiment: EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:14570913]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14690591|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:14699090|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:14685243]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:18039934|PMID:14570913]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:14685243|PMID:14570913]
note: Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
codon start: 1
product: SAM complex subunit SAM50
translation: MTSSSGVDNEISLDSPMPIFNESSTLKPIRVAGVVTTGTDHIDPSVLQAYLDDTIMKSITLGQLVKNADVLNKRLCQHHIALNAKQSFHFQGNTYISDEKETHDVVPLMEVVSQLDILPPKTFTAKTGTNFGNDNDAEAYLQFEKLIDKKYLKLPTRVNLEILRGTKIHSSFLFNSYSSLSPQSILNLKVFSQFYNWNTNKGLDIGQRGARLSLRYEPLFLHKLLHNPHSNESPTLFHEWFLETCWRSTKICSQGTSAPYMYSGTMLSQAGDQLRTILGHTFVLDKRDHIMCPTKGSMLKWSNELSPGKHLKTQLELNSVKSWMNDDFITFSTTIKTGYLKNLSSQQSLPVHICDKFQSGGPSDIRGFQTFGLGPRDLYDAVGGDAFVSYGLSVFSRLPWKKVEKSNFRLHWFFNGGKLVNHDNTSLGNCIGQLSKEHSTSTGIGLVLRHPMARFELNFTLPITAHENDLIRKGFQFGLGLAFL
SIO_010081: YNL026W
subclass of: SO_0000673
so part of: YNL026W
location: 581920..583374
location: region:581920-583374:1
so has part: feature:581920-583374:1:exon

NP_014372.1
type: Protein
SIO_000068: ncbiprotein

S000004971
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:581920-583374:1:exon

YNL025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CNC1
alternative label: GIG3
alternative label: NUT9
alternative label: RYE2
alternative label: SRB11
alternative label: UME3
gene: SSN8
locus tag: YNL025C
gene synonym: CNC1; GIG3; NUT9; RYE2; SRB11; UME3
so part of: sequence
location: complement(<584320..>585291)
location: region:584320-585291:-1
so has part: feature:584320-585291:-1:exon
subclass of: SO_0000010

855706
type: Gene
SIO_000068: ncbigene

position:584320:-1
position: 584320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:585291:-1
position: 585291
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584320-585291:-1:exon

YNL025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CNC1
alternative label: GIG3
alternative label: NUT9
alternative label: RYE2
alternative label: SRB11
alternative label: UME3
gene: SSN8
locus tag: YNL025C
gene synonym: CNC1; GIG3; NUT9; RYE2; SRB11; UME3
product: cyclin-dependent protein serine/threonine kinase regulator SSN8
transcript id: NM_001182864.3
SIO_010081: YNL025C
subclass of: SO_0000673
so part of: YNL025C
location: complement(<584320..>585291)
location: region:584320-585291:-1
so has part: feature:584320-585291:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584320-585291:-1:exon

YNL025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CNC1
alternative label: GIG3
alternative label: NUT9
alternative label: RYE2
alternative label: SRB11
alternative label: UME3
gene: SSN8
locus tag: YNL025C
gene synonym: CNC1; GIG3; NUT9; RYE2; SRB11; UME3
experiment: EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7877695]
experiment: EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:12200444]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14749387]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]
experiment: EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:15601835]
experiment: EXISTENCE:mutant phenotype:GO:0010673 positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle [PMID:12455972]
experiment: EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7732022]
note: Cyclin-like component of RNA polymerase II holoenzyme; involved in phosphorylation of RNAPII C-terminal domain; forms kinase-cyclin pair in RNAPII holoenzyme with Ssn3p; needed for entry into and execution of meiotic program; involved in glucose repression, telomere maintenance; degraded in response to nitrogen starvation, and also to oxidative stress, but in different cellular compartments, and with different cellular outcomes; 35% identical to human cyclin C
codon start: 1
product: cyclin-dependent protein serine/threonine kinase regulator SSN8
translation: MSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVMDSKQNGIEQSITKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLIKASVREINLYMLVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKVTEFEFYLLEELESYLIVHHPYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYINDVHLLYPPHIIAVACLFITISIHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFMAESLVDLEEVMDTIQEQITLYDHWDKYHEQWIKFLLHTLYLRPASAI
SIO_010081: YNL025C
subclass of: SO_0000673
so part of: YNL025C
location: complement(584320..585291)
location: region:584320-585291:-1
so has part: feature:584320-585291:-1:exon

NP_014373.3
type: Protein
SIO_000068: ncbiprotein

S000004970
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584320-585291:-1:exon

YNCN0013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NME1
locus tag: YNCN0013W
so part of: sequence
location: 585587..585926
location: region:585587-585926:1
so has part: feature:585587-585926:1:exon
subclass of: SO_0000011

9164967
type: Gene
SIO_000068: ncbigene

position:585587:1
position: 585587
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:585926:1
position: 585926
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:585587-585926:1:exon

YNCN0013W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: RNase_MRP_RNA
gene: NME1
locus tag: YNCN0013W
product: NME1
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:1398074]
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:8602511]
experiment: EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:8290578|PMID:8602511|PMID:8247008]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:8247008|PMID:8290578]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:22977255]
experiment: EXISTENCE:mutant phenotype:GO:0045787 positive regulation of cell cycle [PMID:12136008]
note: RNA component of RNase MRP; RNase MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; human ortholog is implicated in cartilage-hair hypoplasia (CHH)
transcript id: NR_132251.1
SIO_010081: YNCN0013W
subclass of: SO_0000673
so part of: YNCN0013W
location: 585587..585926
location: region:585587-585926:1
so has part: feature:585587-585926:1:exon

S000007436
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:585587-585926:1:exon

YNCN0014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR66
locus tag: YNCN0014W
so part of: sequence
location: 586090..586175
location: region:586090-586175:1
so has part: feature:586090-586175:1:exon
subclass of: SO_0000578

9164968
type: Gene
SIO_000068: ncbigene

position:586090:1
position: 586090
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:586175:1
position: 586175
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586090-586175:1:exon

YNCN0014W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR66
locus tag: YNCN0014W
product: SNR66
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U2417
transcript id: NR_132252.1
SIO_010081: YNCN0014W
subclass of: SO_0000673
so part of: YNCN0014W
location: 586090..586175
location: region:586090-586175:1
so has part: feature:586090-586175:1:exon

S000006457
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586090-586175:1:exon

YNL024C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KSH1
locus tag: YNL024C-A
so part of: sequence
location: complement(<586602..>586820)
location: region:586602-586820:-1
so has part: feature:586602-586820:-1:exon
subclass of: SO_0000010

1466516
type: Gene
SIO_000068: ncbigene

position:586602:-1
position: 586602
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:586820:-1
position: 586820
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586602-586820:-1:exon

YNL024C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KSH1
locus tag: YNL024C-A
product: Ksh1p
transcript id: NM_001184619.3
SIO_010081: YNL024C-A
subclass of: SO_0000673
so part of: YNL024C-A
location: complement(<586602..>586820)
location: region:586602-586820:-1
so has part: feature:586602-586820:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:586602-586820:-1:exon

YNL024C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KSH1
locus tag: YNL024C-A
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19942856]
note: Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish
codon start: 1
product: Ksh1p
translation: MSALFNFRSLLQVILLLICSCSYVHGQWPSLLDRYKNHEVLGAFWKMARVGERASPYVSLACILMAISQFNS
SIO_010081: YNL024C-A
subclass of: SO_0000673
so part of: YNL024C-A
location: complement(586602..586820)
location: region:586602-586820:-1
so has part: feature:586602-586820:-1:exon

NP_878158.3
type: Protein
SIO_000068: ncbiprotein

S000028698
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586602-586820:-1:exon

YNL024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EFM6
locus tag: YNL024C
so part of: sequence
location: complement(<587107..>587847)
location: region:587107-587847:-1
so has part: feature:587107-587847:-1:exon
subclass of: SO_0000010

855707
type: Gene
SIO_000068: ncbigene

position:587107:-1
position: 587107
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:587847:-1
position: 587847
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:587107-587847:-1:exon

YNL024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EFM6
locus tag: YNL024C
product: putative protein-lysine N-methyltransferase
transcript id: NM_001182863.1
SIO_010081: YNL024C
subclass of: SO_0000673
so part of: YNL024C
location: complement(<587107..>587847)
location: region:587107-587847:-1
so has part: feature:587107-587847:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:587107-587847:-1:exon

YNL024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EFM6
locus tag: YNL024C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: putative protein-lysine N-methyltransferase
translation: MESIFGGFGDLVVPRPKEHLGQTDLSFGGKLLPALKICEDGGESGCGGKVWIAGELLCEYILEKSVDHLLSKTVNGTKQFKKVLELGSGTGLVGLCVGLLEKNTFHDGTKVYVTDIDKLIPLLKRNIELDEVQYEVLARELWWGEPLSADFSPQEGAMQANNVDLVLAADCVYLEEAFPLLEKTLLDLTHCINPPVILMAYKKRRKADKHFFNKIKRNFDVLEITDFSKFEHYLKERTHLFQLIRK
SIO_010081: YNL024C
subclass of: SO_0000673
so part of: YNL024C
location: complement(587107..587847)
location: region:587107-587847:-1
so has part: feature:587107-587847:-1:exon

NP_014374.1
type: Protein
SIO_000068: ncbiprotein

S000004969
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:587107-587847:-1:exon

YNL023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAP1
locus tag: YNL023C
so part of: sequence
location: complement(<588263..>591160)
location: region:588263-591160:-1
so has part: feature:588263-591160:-1:exon
subclass of: SO_0000010

855708
type: Gene
SIO_000068: ncbigene

position:588263:-1
position: 588263
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:591160:-1
position: 591160
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:588263-591160:-1:exon

YNL023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAP1
locus tag: YNL023C
product: Fap1p
transcript id: NM_001182862.1
SIO_010081: YNL023C
subclass of: SO_0000673
so part of: YNL023C
location: complement(<588263..>591160)
location: region:588263-591160:-1
so has part: feature:588263-591160:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:588263-591160:-1:exon

YNL023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAP1
locus tag: YNL023C
experiment: EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10998178|PMID:36113412]
experiment: EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]
note: Protein that acts as sensor of stalled ribosomes; binds to Fpr1p and Smu2p, and triggers ubiquitination of stalled monosomes for subsequent degradation; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
codon start: 1
product: Fap1p
translation: MTEHESLGLEQNQDGGDTYRHHNLSDGCISSVEDANEQPSSYEEESDDDMQYYERAIQEISSGDSYVCMICTVEMDYTCQMFACKRCYRVFDYGCIREWALKSTEKTVDRIWKCPNCYYVSKRVPVKNRPTCWCGKVVNPDPNPLDPNSCGQTCNASTCMHGCSKICHLGPHPECTRMVEIMCHCGKHSKSIFCYQSKVMKKNFNCQEVCGLPLSCSIHTCKKKCHPGLCGPCPEMIISKDSPKKQIKCYCGNHTRANIKCSETKFPKSGKSSKDENGNRWIGVFACADNRVVDYSCRKHSFIESCISPPTINGEKACPFLPSSLKTCPCGRTALEELTKPRKHCDDPIPTCDSRCGKPLKCGKHSCPFTCHDKACMEPCLQIDSVKCACEQSTFSVPCGFQGRPRCNIKCESLMSCRRHRCTDRCCSGRPSAIRRKKNLFRTQDLLDESLVEAKHICLKPCNLTLSCGIHKCQRKCHPGKCPPCLESDSNDLVCPCGNTVVPAPVRCGTKLPTCNHPCIKVVRGESTCGHKPMPHTCHSLDVSCPPCTETVFKPCKCGKKTKVRTVCFQTDVSCGIKCGIPLSYCYHTCQKTCHLPGNCQKVCKQTCGQKRLNCNHECPKPCHGKTECPDLPCATLVKIYCKCGRIKKSVTCGAKSDRVSVTESSVLDCNEECEALKRLKELKEAFGIKEETNNFTSNELDALKKLVSVATTFEELQLPFTEAALSVYSKQERWCSQIEAILNKLMDDKTRSSLHFKPMRPPQRHFIRELAKAYGLYSESQDREPMRSVFIKKEDNGASNKPVLSLAEAYPLYESFKQLQKERKAQEFQARTTAKLINFEVQDTEPKVEVAKKNGFLVQNLVAGNTAEDLRRFFEPHLKHTLVVNPQYLILDDGKTALVYPENYETASVNTERDMELLVGHFDFMAKEAFLADSISLCSTEEELERRLDTPVIQEDSPVMDNNT
SIO_010081: YNL023C
subclass of: SO_0000673
so part of: YNL023C
location: complement(588263..591160)
location: region:588263-591160:-1
so has part: feature:588263-591160:-1:exon

NP_014375.1
type: Protein
SIO_000068: ncbiprotein

S000004968
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:588263-591160:-1:exon

YNL022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCM1
locus tag: YNL022C
so part of: sequence
location: complement(<591427..>592899)
location: region:591427-592899:-1
so has part: feature:591427-592899:-1:exon
subclass of: SO_0000010

855709
type: Gene
SIO_000068: ncbigene

position:591427:-1
position: 591427
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592899:-1
position: 592899
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:591427-592899:-1:exon

YNL022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCM1
locus tag: YNL022C
product: rRNA (cytosine-C5-)-methyltransferase RCM1
transcript id: NM_001182861.3
SIO_010081: YNL022C
subclass of: SO_0000673
so part of: YNL022C
location: complement(<591427..>592899)
location: region:591427-592899:-1
so has part: feature:591427-592899:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:591427-592899:-1:exon

YNL022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCM1
locus tag: YNL022C
EC number: 2.1.1.311
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10649453]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23913415]
experiment: EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]
experiment: EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]
experiment: EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]
experiment: EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]
note: rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome
codon start: 1
product: rRNA (cytosine-C5-)-methyltransferase RCM1
translation: MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLSEDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTLKVDKWSELVPGSIYYDEFIPNLFGIHPSDKITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAMSFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD
SIO_010081: YNL022C
subclass of: SO_0000673
so part of: YNL022C
location: complement(591427..592899)
location: region:591427-592899:-1
so has part: feature:591427-592899:-1:exon

NP_014376.3
type: Protein
SIO_000068: ncbiprotein

S000004967
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:591427-592899:-1:exon

YNL021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HDA1
locus tag: YNL021W
so part of: sequence
location: <593227..>595347
location: region:593227-595347:1
so has part: feature:593227-595347:1:exon
subclass of: SO_0000010

855710
type: Gene
SIO_000068: ncbigene

position:593227:1
position: 593227
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:595347:1
position: 595347
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593227-595347:1:exon

YNL021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HDA1
locus tag: YNL021W
product: histone deacetylase HDA1
transcript id: NM_001182860.1
SIO_010081: YNL021W
subclass of: SO_0000673
so part of: YNL021W
location: <593227..>595347
location: region:593227-595347:1
so has part: feature:593227-595347:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593227-595347:1:exon

YNL021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HDA1
locus tag: YNL021W
EC number: 3.5.1.98
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]
experiment: EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]
experiment: EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:11287668|PMID:8663039|PMID:8962081]
experiment: EXISTENCE:genetic interaction:GO:0010621 negative regulation of transcription by transcription factor localization [PMID:17974563]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11172717|PMID:17121596]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]
experiment: EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]
note: Catalytic subunit of class II HDA1 histone deacetylase complex; role in azole resistance via Hsp90p, and in heat shock response; Hda1p interacts with Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism
codon start: 1
product: histone deacetylase HDA1
translation: MDSVMVKKEVLENPDHDLKRKLEENKEEENSLSTTSKSKRQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSLDFIKWGLDRKYGIIDVNIPLTLFEPDNYSGMITSQEVLIYLWDNYIKYFPSVAKIAFIGIGDSYSGIVHLLGHRDTRAVTKTVINFLGDKQLKPLVPLVDETLSEWYFKNSLIFSNNSHQCWKENESRKPRKKFGRVLRCDTDGLNNIIEERFEEATDFILDSFEEWSDEE
SIO_010081: YNL021W
subclass of: SO_0000673
so part of: YNL021W
location: 593227..595347
location: region:593227-595347:1
so has part: feature:593227-595347:1:exon

NP_014377.1
type: Protein
SIO_000068: ncbiprotein

S000004966
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593227-595347:1:exon

YNL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARK1
locus tag: YNL020C
so part of: sequence
location: complement(<595623..>597539)
location: region:595623-597539:-1
so has part: feature:595623-597539:-1:exon
subclass of: SO_0000010

855711
type: Gene
SIO_000068: ncbigene

position:595623:-1
position: 595623
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:597539:-1
position: 597539
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:595623-597539:-1:exon

YNL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARK1
locus tag: YNL020C
product: serine/threonine protein kinase ARK1
transcript id: NM_001182859.1
SIO_010081: YNL020C
subclass of: SO_0000673
so part of: YNL020C
location: complement(<595623..>597539)
location: region:595623-597539:-1
so has part: feature:595623-597539:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:595623-597539:-1:exon

YNL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARK1
locus tag: YNL020C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:17978096]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10087264]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10087264]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10087264]
experiment: EXISTENCE:mutant phenotype:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]
note: Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1
codon start: 1
product: serine/threonine protein kinase ARK1
translation: MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQNIIPQYEDSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHENSPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNLKNSIQQRMIDKLNSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKDKKTKPTPPPKPSHLKPKPPPKPLLLAGRKLSLDK
SIO_010081: YNL020C
subclass of: SO_0000673
so part of: YNL020C
location: complement(595623..597539)
location: region:595623-597539:-1
so has part: feature:595623-597539:-1:exon

NP_014378.1
type: Protein
SIO_000068: ncbiprotein

S000004965
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:595623-597539:-1:exon

YNL019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL019C
so part of: sequence
location: complement(<598376..>599230)
location: region:598376-599230:-1
so has part: feature:598376-599230:-1:exon
subclass of: SO_0000010

855712
type: Gene
SIO_000068: ncbigene

position:598376:-1
position: 598376
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:599230:-1
position: 599230
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:598376-599230:-1:exon

YNL019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL019C
product: uncharacterized protein
transcript id: NM_001182858.3
SIO_010081: YNL019C
subclass of: SO_0000673
so part of: YNL019C
location: complement(<598376..>599230)
location: region:598376-599230:-1
so has part: feature:598376-599230:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:598376-599230:-1:exon

YNL019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL019C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
note: hypothetical protein; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MLYSRESRTTVLFLALVTSLTVLCHSVDVTTVFTTSTITEITTVTAAPQPQNKAETALNTATNIIQTMQFLFNCAPFKWKGPLKITSCALNFIVLLLTAWGYLLKYLQENKLNSDADMEKMVGLGFGEMVGRIFGKGVGKAFTKMDITQKLVYPFEGSNRQKCLLMTVGENSIVPFHDLSTEICFDQYTLDSLSHHNHGSISILDAGSVSALGFADISSKMPSVSELYTLFGDYTIEVLGGITKLASTLNREDWQGERNGFAVLSRDRPNQTLLSVHMYSSSLL
SIO_010081: YNL019C
subclass of: SO_0000673
so part of: YNL019C
location: complement(598376..599230)
location: region:598376-599230:-1
so has part: feature:598376-599230:-1:exon

NP_014379.3
type: Protein
SIO_000068: ncbiprotein

S000004964
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:598376-599230:-1:exon

YNL018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL018C
so part of: sequence
location: complement(<599936..>601774)
location: region:599936-601774:-1
so has part: feature:599936-601774:-1:exon
subclass of: SO_0000010

855713
type: Gene
SIO_000068: ncbigene

position:599936:-1
position: 599936
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:601774:-1
position: 601774
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599936-601774:-1:exon

YNL018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL018C
product: uncharacterized protein
transcript id: NM_001182857.3
SIO_010081: YNL018C
subclass of: SO_0000673
so part of: YNL018C
location: complement(<599936..>601774)
location: region:599936-601774:-1
so has part: feature:599936-601774:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:599936-601774:-1:exon

YNL018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL018C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
note: Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; YNL018C has a paralog, YNL034W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MSTSFQEFKAFCNKVGLDFQWLNLQSSKSVPENGSSEGFSAVSDTVQENIRPATEPLNVNQSKDPVSNFFYDVKNAPLWNVYKRNHSGHSSAEACSGVSSRQAPKNIPEAMVKETVLSNHDNVTIINELLPTSSAMHQEESTAMTTSYLLSHSVNDTCNVMFSSSSHNRAMLPSSLVQRNNATTSPTTDSASENNESVPSLTSSVSTSSSVYSSWNPPHSPHISSFPDGNFASLNAEVTCFDFRRTKDSRTKETNESIIPTEIYCPTNSTDHHKHYPSRKSKQDACAPAPCNQNISCSVVSTAEFSQSNHTLTTVVPSYMQQYLDRPQNWFESKMGKYCPLFLRSTKNIDYDSLEFKFERKMIAVQYLLLDEQSEPRRYYNPSNKSIPFWKRPFNFDTMPSYDQLMEEAECRFYSYQYKYEGFQRIEPYSISCPWKNTQREIDLVLDHIHFSLDVGEKKSLNRKGNITLDTLDSKVDPNIQIKPYQIFPSNNLVYEGLPHPAEQSLILSPDTSLIERAFQALIDICKESIPSSNDCSTRNNNSAPQLTVPEPSKPCRLLLVRESRTATELKTNKKLWLHSQRRNIEVTVPMHPSERGTKSWLRKWLSTFVHQ
SIO_010081: YNL018C
subclass of: SO_0000673
so part of: YNL018C
location: complement(599936..601774)
location: region:599936-601774:-1
so has part: feature:599936-601774:-1:exon

NP_014380.3
type: Protein
SIO_000068: ncbiprotein

S000004963
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:599936-601774:-1:exon

YNCN0015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0015W
so part of: sequence
location: 602312..602385
location: region:602312-602385:1
so has part: feature:602312-602385:1:exon
subclass of: SO_0000663

855714
type: Gene
SIO_000068: ncbigene

position:602312:1
position: 602312
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:602385:1
position: 602385
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:602312-602385:1:exon

YNCN0015W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0015W
product: tRNA-Ile
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0015W
subclass of: SO_0000673
so part of: YNCN0015W
location: 602312..602385
location: region:602312-602385:1
so has part: feature:602312-602385:1:exon

S000006610
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:602312-602385:1:exon

YNL016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RNP1
gene: PUB1
locus tag: YNL016W
gene synonym: RNP1
so part of: sequence
location: <602907..>604268
location: region:602907-604268:1
so has part: feature:602907-604268:1:exon
subclass of: SO_0000010

855716
type: Gene
SIO_000068: ncbigene

position:602907:1
position: 602907
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:604268:1
position: 604268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:602907-604268:1:exon

YNL016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RNP1
gene: PUB1
locus tag: YNL016W
gene synonym: RNP1
product: Pub1p
transcript id: NM_001182855.1
SIO_010081: YNL016W
subclass of: SO_0000673
so part of: YNL016W
location: <602907..>604268
location: region:602907-604268:1
so has part: feature:602907-604268:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:602907-604268:1:exon

YNL016W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RNP1
gene: PUB1
locus tag: YNL016W
gene synonym: RNP1
experiment: EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:10892745]
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:15964806|PMID:8413212|PMID:8413213|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8413212]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8413212|PMID:8413213]
experiment: EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:8413213]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:24291094|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:28467675]
experiment: EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:8413212|PMID:8413213]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:28467675]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]
experiment: EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:15964806]
experiment: EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:28467675]
note: Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds cell wall mRNAs; required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; implicated in regulation of translation; carries Q/N-rich domain at C- terminus, identified as candidate prion; ribosome-bound Pub1p modulates stop codon decoding during translation termination
codon start: 1
product: Pub1p
translation: MSENNEEQHQQQQQQQPVAVETPSAVEAPASADPSSEQSVAVEGNSEQAEDNQGENDPSVVPANAITGGRETSDRVLYVGNLDKAITEDILKQYFQVGGPIANIKIMIDKNNKNVNYAFVEYHQSHDANIALQTLNGKQIENNIVKINWAFQSQQSSSDDTFNLFVGDLNVNVDDETLRNAFKDFPSYLSGHVMWDMQTGSSRGYGFVSFTSQDDAQNAMDSMQGQDLNGRPLRINWAAKRDNNNNNNYQQRRNYGNNNRGGFRQYNSNNNNNMNMGMNMNMNMNMNNSRGMPPSSMGMPIGAMPLPSQGQPQQSQTIGLPPQVNPQAVDHIIRSAPPRVTTAYIGNIPHFATEADLIPLFQNFGFILDFKHYPEKGCCFIKYDTHEQAAVCIVALANFPFQGRNLRTGWGKERSNFMPQQQQQGGQPLIMNDQQQPVMSEQQQQQQQQQQQQ
SIO_010081: YNL016W
subclass of: SO_0000673
so part of: YNL016W
location: 602907..604268
location: region:602907-604268:1
so has part: feature:602907-604268:1:exon

NP_014382.1
type: Protein
SIO_000068: ncbiprotein

S000004961
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:602907-604268:1:exon

YNL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LMA1
gene: PBI2
locus tag: YNL015W
gene synonym: LMA1
so part of: sequence
location: <605384..>605611
location: region:605384-605611:1
so has part: feature:605384-605611:1:exon
subclass of: SO_0000010

855717
type: Gene
SIO_000068: ncbigene

position:605384:1
position: 605384
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:605611:1
position: 605611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605384-605611:1:exon

YNL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LMA1
gene: PBI2
locus tag: YNL015W
gene synonym: LMA1
product: Pbi2p
transcript id: NM_001182854.1
SIO_010081: YNL015W
subclass of: SO_0000673
so part of: YNL015W
location: <605384..>605611
location: region:605384-605611:1
so has part: feature:605384-605611:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:605384-605611:1:exon

YNL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LMA1
gene: PBI2
locus tag: YNL015W
gene synonym: LMA1
experiment: EXISTENCE:direct assay:GO:0004866 endopeptidase inhibitor activity [PMID:2015812]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:9159115]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9159115]
experiment: EXISTENCE:mutant phenotype:GO:0030162 regulation of proteolysis [PMID:2015812]
note: Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress
codon start: 1
product: Pbi2p
translation: MTKNFIVTLKKNTPDVEAKKFLDSVHHAGGSIVHEFDIIKGYTIKVPDVLHLNKLKEKHNDVIENVEEDKEVHTN
SIO_010081: YNL015W
subclass of: SO_0000673
so part of: YNL015W
location: 605384..605611
location: region:605384-605611:1
so has part: feature:605384-605611:1:exon

NP_014383.1
type: Protein
SIO_000068: ncbiprotein

S000004960
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605384-605611:1:exon

YNL014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ZRG7
gene: HEF3
locus tag: YNL014W
gene synonym: ZRG7
so part of: sequence
location: <606319..>609453
location: region:606319-609453:1
so has part: feature:606319-609453:1:exon
subclass of: SO_0000010

855718
type: Gene
SIO_000068: ncbigene

position:606319:1
position: 606319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:609453:1
position: 609453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:606319-609453:1:exon

YNL014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ZRG7
gene: HEF3
locus tag: YNL014W
gene synonym: ZRG7
product: translation elongation factor EF-3
transcript id: NM_001182853.3
SIO_010081: YNL014W
subclass of: SO_0000673
so part of: YNL014W
location: <606319..>609453
location: region:606319-609453:1
so has part: feature:606319-609453:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:606319-609453:1:exon

YNL014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ZRG7
gene: HEF3
locus tag: YNL014W
gene synonym: ZRG7
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9544245]
experiment: EXISTENCE:genetic interaction:GO:0003746 translation elongation factor activity [PMID:9544245]
experiment: EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:9544245]
experiment: EXISTENCE:physical interaction:GO:0022626 cytosolic ribosome [PMID:9544245]
note: Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication
codon start: 1
product: translation elongation factor EF-3
translation: MSDSQQSITVLEELFRKLETATSETREGISSELSSFLNGNIIEHDVPEVFFDEFQKAIQSKQKALNTLGAVAYIANETNLSPSVEPYIVATVPSVCSKAGSKDNDVQLAATKALKAIASAVNPVAVKALLPHLIHSLETSNKWKEKVAVLEVISVLVDAAKEQIALRMPELIPVLSESMWDTKKGVKEAATTTITKATETVDNKDIERFIPKLIECIANPNEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLAERETSIKRKAAVIIDNMCKLVEDPQVVAPFLGKLLPGLKNNFATIADPEAREVTLKALKTLRRVGNVGEDDVLPEISHAGDVSTTLGVIKELLEPEKVAPRFTIVVEYIAAIAANLIDERIIDQQTWFTHVTPYMTIFLHEKTAKEILDDFRKRAVDNIPVGPNFQDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRGRRYGLCGPNGAGKSTLMRSIANGQVDGFPTQDECRTVYVEHDIDNTHSDMSVLDFVYSGNVGTKDVITSKLKEFGFSDEMIEMPIASLSGGWKMKLALARAVLKDADILLLDEPTNHLDTVNVEWLVNYLNTCGITSVIVSHDSGFLDKVCQYIIHYEGLKLRKYKGNLSEFVQKCPTAQSYYELGASDLEFQFPTPGYLEGVKTKQKAIVKVSNMTFQYPGTTKPQVSDVTFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRVAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWLPRGELIESHSKMVAEIDMKEALASGQFRALTRKEIELHCAMLGLDSELVSHSRIRGLSGGQKVKLVLAACTWQRPHLIVLDEPTNYLDRDSLGALSKALKAFEGGVIIITHSAEFTKNLTDEVWAVKDGKMTPSGHNWVAGQGAGPRIEKKEEEGDKFDAMGNKINSGKKKSKLSSAELRKKKKERMKKKKEMGDEYVSSDEDF
SIO_010081: YNL014W
subclass of: SO_0000673
so part of: YNL014W
location: 606319..609453
location: region:606319-609453:1
so has part: feature:606319-609453:1:exon

NP_014384.3
type: Protein
SIO_000068: ncbiprotein

S000004959
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:606319-609453:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1424; Autonomously Replicating Sequence
so part of: sequence
location: 609520..609607
location: region:609520-609607:1
so has part: feature:609520-609607:1:region

S000118391
type: SGD
SIO_000068: sgd

position:609520:1
position: 609520
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:609607:1
position: 609607
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:609520-609607:1:region

YNL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO1
locus tag: YNL012W
so part of: sequence
location: <609686..>611665
location: region:609686-611665:1
so has part: feature:609686-611665:1:exon
subclass of: SO_0000010

855720
type: Gene
SIO_000068: ncbigene

position:609686:1
position: 609686
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611665:1
position: 611665
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:609686-611665:1:exon

YNL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO1
locus tag: YNL012W
product: putative carboxylic ester hydrolase
transcript id: NM_001182851.1
SIO_010081: YNL012W
subclass of: SO_0000673
so part of: YNL012W
location: join(<609686..609790,609875..>611665)
location: region:609686-611665:1
so has part: feature:609686-609790:1:exon
so has part: feature:609875-611665:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:609686-609790:1:exon

position:609790:1
position: 609790
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:609875-611665:1:exon

position:609875:1
position: 609875
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO1
locus tag: YNL012W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10855497]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17179081]
experiment: EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022]
experiment: EXISTENCE:genetic interaction:GO:0070583 spore membrane bending pathway [PMID:18756268]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10855497]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022|PMID:26605945]
experiment: EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]
note: Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
codon start: 1
product: putative carboxylic ester hydrolase
translation: MQKLLFVFSVLLTVVLATAPFQVQCPSSPLIREAKHELCPEETLYLKKKKIKTKNKLIQFLKSLTEAKFSSKFYKRVLKDPPKIGIAISGGGYRSMLVGTGFISQMNDYGLFEYSDYIAGLSGGSWILMDLVVQNFEVKSLLQEWDLEEDLLLGIPEFDISEEEIVTNAKKEYNDNDLKMKKRQGGSLITSSSNFYEQIEEIMNSIEEIPEDYMITKRNLNPLARLKKIFFPNNTFTGTDAKIETFKKVLDFYKSLHLKIKPKKMEGFQISFTDYWGKAIVQRLKKNFDDDPNHSFSFSKLVNSSKKFKECSVPIPIFVANCKNGLLSNVIFEFTPFEFGSWENILRLFVKLPYLGSKIVSGKAEKCINNFDDLGFITATSSSIFNNVLIFIWNLASQSSREAMKALNMVMGIFGLGKEEIFSISKDSSRLETDYAVYQPNPFYLYPEKDNVLTNKNHLYLVDGGEDGENIPLRTLVIPERELDVIFVLDSSSDIDNYPNGSKLKRIFEKLDEENVHYQFPNNVKTFTHPIVIGCNATKRTGHDSFLPIIIYHANANHGNASNTSTFKITYNQSEVSSMLPTGRGVFSNDYDLYYKNCLGCILTKRTMDRLPRKKKFSPFCLQCFKDYCYS
SIO_010081: YNL012W
subclass of: SO_0000673
so part of: YNL012W
location: join(609686..609790,609875..611665)
location: region:609686-611665:1
so has part: feature:609686-609790:1:exon
so has part: feature:609875-611665:1:exon

NP_014386.2
type: Protein
SIO_000068: ncbiprotein

S000004957
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:609686-609790:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:609875-611665:1:exon

YNL011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNL011C
so part of: sequence
location: complement(<611836..>613170)
location: region:611836-613170:-1
so has part: feature:611836-613170:-1:exon
subclass of: SO_0000010

855721
type: Gene
SIO_000068: ncbigene

position:611836:-1
position: 611836
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:613170:-1
position: 613170
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611836-613170:-1:exon

YNL011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNL011C
product: uncharacterized protein
transcript id: NM_001182850.1
SIO_010081: YNL011C
subclass of: SO_0000673
so part of: YNL011C
location: complement(<611836..>613170)
location: region:611836-613170:-1
so has part: feature:611836-613170:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611836-613170:-1:exon

YNL011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNL011C
note: hypothetical protein; YNL011C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MNVVVCSGGTATNSLTPCFSNISILKGHELTYILPISDNGGSTSEILRIVGGPAIGDIRSRIVRLLQDEQLVELFGHRLPNDKLLAKKEWNEIVEGSHPIWKNISIEVKEMCRSFIIHMQAELLKKIKHSNPFQFESASIGNFFLTGARLFLGSLDASIELMMRIGRCSPLVHVIPCINTNHTHHISALLTNGEMITGQSQISHPSKSVPKDNSIAHSAKFIHLLGSYDDHLKILLDDEEEEAEEEYANPIYILPELKNSQLHFDKLDESQNLPAPVHRILYINPYGEEIKPMGNPRAISKVKKADMVVYSIGSLMTSLLPILILGNLAEVILESNNTKKVLLINNKYDREVFGLDGLHYVQMIIDSMSRAIAGYRQSKGVHSENDDFEWQDFITDIVYLKNGEIEIDETIFEKHSIRCHQIASSDKMESEELEKVLNQIGLKN
SIO_010081: YNL011C
subclass of: SO_0000673
so part of: YNL011C
location: complement(611836..613170)
location: region:611836-613170:-1
so has part: feature:611836-613170:-1:exon

NP_014387.1
type: Protein
SIO_000068: ncbiprotein

S000004956
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611836-613170:-1:exon

YNL010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PYP1
locus tag: YNL010W
so part of: sequence
location: <613635..>614360
location: region:613635-614360:1
so has part: feature:613635-614360:1:exon
subclass of: SO_0000010

855722
type: Gene
SIO_000068: ncbigene

position:613635:1
position: 613635
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:614360:1
position: 614360
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:613635-614360:1:exon

YNL010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PYP1
locus tag: YNL010W
product: putative phosphoric monoester hydrolase
transcript id: NM_001182849.3
SIO_010081: YNL010W
subclass of: SO_0000673
so part of: YNL010W
location: <613635..>614360
location: region:613635-614360:1
so has part: feature:613635-614360:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:613635-614360:1:exon

YNL010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PYP1
locus tag: YNL010W
EC number: 3.1.3.50
experiment: EXISTENCE:direct assay:GO:0000121 glycerol-1-phosphatase activity [PMID:26071590]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0043136 glycerol-3-phosphatase activity [PMID:30240188]
experiment: EXISTENCE:direct assay:GO:0050286 sorbitol-6-phosphatase activity [PMID:30240188]
experiment: EXISTENCE:direct assay:GO:0110130 ribitol-5-phosphatase activity [PMID:30240188]
experiment: EXISTENCE:mutant phenotype:GO:0052646 alditol phosphate metabolic process [PMID:30240188]
note: Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily
codon start: 1
product: putative phosphoric monoester hydrolase
translation: MVKAVIFTDFDGTVTLEDSNDYLTDTLGFGKEKRLKVFEGVLDDTKSFRQGFMEMLESIHTPFPECIKILEKKIRLDPGFKDTFEWAQENDVPVIVVSSGMKPIIKVLLTRLVGQESIHKIDIVSNEVEIDAHDQWKIIYKDESPFGHDKSRSIDAYKKKFESTLKAGEQRPVYFYCGDGVSDLSAAKECDLLFAKRGKDLVTYCKKQNVPFHEFDTFKDILASMKQVLAGEKTVAELMEN
SIO_010081: YNL010W
subclass of: SO_0000673
so part of: YNL010W
location: 613635..614360
location: region:613635-614360:1
so has part: feature:613635-614360:1:exon

NP_014388.3
type: Protein
SIO_000068: ncbiprotein

S000004955
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:613635-614360:1:exon

YNL009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IDP3
locus tag: YNL009W
so part of: sequence
location: <614821..>616083
location: region:614821-616083:1
so has part: feature:614821-616083:1:exon
subclass of: SO_0000010

855723
type: Gene
SIO_000068: ncbigene

position:614821:1
position: 614821
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:616083:1
position: 616083
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:614821-616083:1:exon

YNL009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IDP3
locus tag: YNL009W
product: isocitrate dehydrogenase (NADP(+)) IDP3
transcript id: NM_001182848.3
SIO_010081: YNL009W
subclass of: SO_0000673
so part of: YNL009W
location: <614821..>616083
location: region:614821-616083:1
so has part: feature:614821-616083:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:614821-616083:1:exon

YNL009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IDP3
locus tag: YNL009W
EC number: 1.1.1.42
experiment: EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:9452501]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15001388|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9452501|PMID:22375831]
experiment: EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:9452501]
note: Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
codon start: 1
product: isocitrate dehydrogenase (NADP(+)) IDP3
translation: MSKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSSYATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLVPHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKSGGIAMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEKFQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNLLEKATLDTVQVGGKMTKDLALMLGKTNRSSYVTTEEFIDEVAKRLQNMMLSSNEDKKGMCKL
SIO_010081: YNL009W
subclass of: SO_0000673
so part of: YNL009W
location: 614821..616083
location: region:614821-616083:1
so has part: feature:614821-616083:1:exon

NP_014389.3
type: Protein
SIO_000068: ncbiprotein

S000004954
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:614821-616083:1:exon

YNL008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASI3
locus tag: YNL008C
so part of: sequence
location: complement(<616211..>618241)
location: region:616211-618241:-1
so has part: feature:616211-618241:-1:exon
subclass of: SO_0000010

855724
type: Gene
SIO_000068: ncbigene

position:616211:-1
position: 616211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:618241:-1
position: 618241
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616211-618241:-1:exon

YNL008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASI3
locus tag: YNL008C
product: putative ubiquitin-protein ligase ASI3
transcript id: NM_001182847.2
SIO_010081: YNL008C
subclass of: SO_0000673
so part of: YNL008C
location: complement(<616211..>618241)
location: region:616211-618241:-1
so has part: feature:616211-618241:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:616211-618241:-1:exon

YNL008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASI3
locus tag: YNL008C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]
experiment: EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11454748]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]
experiment: EXISTENCE:mutant phenotype:GO:0036369 transcription factor catabolic process [PMID:25253722]
experiment: EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]
note: Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids
codon start: 1
product: putative ubiquitin-protein ligase ASI3
translation: MSTNILQHVKQLLHNRDVFSFFHNKTGNLNYLDNTTQKPEVFVSPNSTIVSAPTLDSFQALMEKGNFTTLQLAKVGIRMFFSYSVSKYAVLCFSTAIILNRLTVMSSLRSNSTNIRLPLWSKTLLHLVATLSLVKALLQILSQFGLMHELHVSDTDFYALSVYLFVALSDCIEIFISSTTNVPSLICSDFSIWGLSLNLYIISKMPAGQQHIGDNVELLGAVFHRLVIHLVELFHIRAYRLCGEVILNAGFFTAFVTRTYLNGLDFINICLIHNYFPGFFYISTILLASIGIFLKALFTSNPFRSLYSRYKNLEKWWRSNNYNGEEEFNEIALSLCLLLTSNDYKIFKKSDNVKSVDEVAAFSNSYVVSGHLNQLQSTPEDLLSRKEMTTDSQLPGFARTYLGLFELVRTIILTYSRLLKNLLWSKNFESSIDKKPRVGKRKKRDLNKYVTEKNYKKFLYKPDVKELNIESDLRSLELLLPEDDSSKDYFPPRKIDESVSDEEFDSDMESQLIIDEEKELTHLSSNAVDSDDLEEIAWNISMWSILNYEMDVHNKVNGPLTRSQYGKRNPQGVLVDVVIERLLHHTNSRYMYKRLNMKDDDKLEFKFDFAFDSCDEVEEMDLSCLICKVNKRNIVTWPCRCLALCDDCRISLGYKGFATCVSCDSEVKGYSKLNIV
SIO_010081: YNL008C
subclass of: SO_0000673
so part of: YNL008C
location: complement(616211..618241)
location: region:616211-618241:-1
so has part: feature:616211-618241:-1:exon

NP_014390.2
type: Protein
SIO_000068: ncbiprotein

S000004953
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:616211-618241:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1425; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 616311..617125
location: region:616311-617125:1
so has part: feature:616311-617125:1:region

S000130144
type: SGD
SIO_000068: sgd

position:616311:1
position: 616311
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:617125:1
position: 617125
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616311-617125:1:region

YNL007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SIS1
locus tag: YNL007C
so part of: sequence
location: complement(<618507..>619565)
location: region:618507-619565:-1
so has part: feature:618507-619565:-1:exon
subclass of: SO_0000010

855725
type: Gene
SIO_000068: ncbigene

position:618507:-1
position: 618507
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:619565:-1
position: 619565
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:618507-619565:-1:exon

YNL007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SIS1
locus tag: YNL007C
product: type II HSP40 co-chaperone SIS1
transcript id: NM_001182846.1
SIO_010081: YNL007C
subclass of: SO_0000673
so part of: YNL007C
location: complement(<618507..>619565)
location: region:618507-619565:-1
so has part: feature:618507-619565:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:618507-619565:-1:exon

YNL007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SIS1
locus tag: YNL007C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:33326013]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:33293525]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9774392]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8513501]
experiment: EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:23791384|PMID:33293525]
experiment: EXISTENCE:mutant phenotype:GO:0002236 detection of misfolded protein [PMID:33293525]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8513501]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:14657253]
experiment: EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:33293525]
experiment: EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]
experiment: EXISTENCE:mutant phenotype:GO:0070843 misfolded protein transport [PMID:23791384]
experiment: EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:23791384]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]
note: Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
codon start: 1
product: type II HSP40 co-chaperone SIS1
translation: MVKETKLYDLLGVSPSANEQELKKGYRKAALKYHPDKPTGDTEKFKEISEAFEILNDPQKREIYDQYGLEAARSGGPSFGPGGPGGAGGAGGFPGGAGGFSGGHAFSNEDAFNIFSQFFGGSSPFGGADDSGFSFSSYPSGGGAGMGGMPGGMGGMHGGMGGMPGGFRSASSSPTYPEEETVQVNLPVSLEDLFVGKKKSFKIGRKGPHGASEKTQIDIQLKPGWKAGTKITYKNQGDYNPQTGRRKTLQFVIQEKSHPNFKRDGDDLIYTLPLSFKESLLGFSKTIQTIDGRTLPLSRVQPVQPSQTSTYPGQGMPTPKNPSQRGNLIVKYKVDYPISLNDAQKRAIDENF
SIO_010081: YNL007C
subclass of: SO_0000673
so part of: YNL007C
location: complement(618507..619565)
location: region:618507-619565:-1
so has part: feature:618507-619565:-1:exon

NP_014391.1
type: Protein
SIO_000068: ncbiprotein

S000004952
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:618507-619565:-1:exon

YNL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LST8
locus tag: YNL006W
so part of: sequence
location: <620067..>620978
location: region:620067-620978:1
so has part: feature:620067-620978:1:exon
subclass of: SO_0000010

855726
type: Gene
SIO_000068: ncbigene

position:620067:1
position: 620067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:620978:1
position: 620978
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:620067-620978:1:exon

YNL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LST8
locus tag: YNL006W
product: TOR complex subunit LST8
transcript id: NM_001182845.3
SIO_010081: YNL006W
subclass of: SO_0000673
so part of: YNL006W
location: <620067..>620978
location: region:620067-620978:1
so has part: feature:620067-620978:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:620067-620978:1:exon

YNL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LST8
locus tag: YNL006W
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12719473]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:12719473]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:12719473]
experiment: EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12719473]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:12719473]
experiment: EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:11742997]
experiment: EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:16002396]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]
note: Subunit of TORC1 and TORC2 involved in TOR signaling; TORC1 regulates nutrient responsive growth and TORC2 regulates plasma membrane (PM) homeostasis and cell-cycle dependent actin cytoskeleton polarization; negative regulator of Rtg1p/3p and Gln3p transcription factors and amino acid biosynthesis; binds to both Tor1p and Tor2p, regulating the integrity and kinase activity of TORC2; PM retention is dependent on Avo3p; WD-repeat protein
codon start: 1
product: TOR complex subunit LST8
translation: MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV
SIO_010081: YNL006W
subclass of: SO_0000673
so part of: YNL006W
location: 620067..620978
location: region:620067-620978:1
so has part: feature:620067-620978:1:exon

NP_014392.3
type: Protein
SIO_000068: ncbiprotein

S000004951
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:620067-620978:1:exon

YNL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bL27m
gene: MRP7
locus tag: YNL005C
gene synonym: bL27m
so part of: sequence
location: complement(<621313..>622428)
location: region:621313-622428:-1
so has part: feature:621313-622428:-1:exon
subclass of: SO_0000010

855727
type: Gene
SIO_000068: ncbigene

position:621313:-1
position: 621313
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:622428:-1
position: 622428
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:621313-622428:-1:exon

YNL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bL27m
gene: MRP7
locus tag: YNL005C
gene synonym: bL27m
product: mitochondrial 54S ribosomal protein YmL2
transcript id: NM_001182844.1
SIO_010081: YNL005C
subclass of: SO_0000673
so part of: YNL005C
location: complement(<621313..>622428)
location: region:621313-622428:-1
so has part: feature:621313-622428:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:621313-622428:-1:exon

YNL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bL27m
gene: MRP7
locus tag: YNL005C
gene synonym: bL27m
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:28931599]
note: Mitochondrial ribosomal protein of the large subunit; involved together with Mrpl35p in assembly of cytochrome c oxidase
codon start: 1
product: mitochondrial 54S ribosomal protein YmL2
translation: MWNPILLDTSSFSFQKHVSGVFLQVRNATKRAAGSRTSMKDSAGRRLGPKKYEGQDVSTGEIIMRQRGTKFYPGENVGIGKDHSIFALEPGVVRYYLDPFHPKRKFIGVALRRDLKLPSPHFEPTVRRFGRFELTNKRAAYKEENSISRKDYLAKPNILKQLEVRESKRKELQDKLSKVLRDELKLDIKDIELATSYLIRVRASLKNGYPIEDARFNSRYYLKEEERLKARRESWTNEKLSESLSKIDECSDLLNSSTSFNNKLELHQYISEQEKQALKAKLLEDLEKSQHLETKKDKNYIKALFKDACNFLTLSEEVHLRRKYLKSVFPETDSTVETKSGKKSIVSRRFDYTKNKVEVIARSRRAFLSKL
SIO_010081: YNL005C
subclass of: SO_0000673
so part of: YNL005C
location: complement(621313..622428)
location: region:621313-622428:-1
so has part: feature:621313-622428:-1:exon

NP_014393.1
type: Protein
SIO_000068: ncbiprotein

S000004950
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:621313-622428:-1:exon

YNL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TOM34
gene: HRB1
locus tag: YNL004W
gene synonym: TOM34
so part of: sequence
location: <622915..>624621
location: region:622915-624621:1
so has part: feature:622915-624621:1:exon
subclass of: SO_0000010

855728
type: Gene
SIO_000068: ncbigene

position:622915:1
position: 622915
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:624621:1
position: 624621
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:622915-624621:1:exon

YNL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TOM34
gene: HRB1
locus tag: YNL004W
gene synonym: TOM34
product: mRNA-binding protein
transcript id: NM_001182843.1
SIO_010081: YNL004W
subclass of: SO_0000673
so part of: YNL004W
location: join(<622915..622944,623287..>624621)
location: region:622915-624621:1
so has part: feature:622915-622944:1:exon
so has part: feature:623287-624621:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:622915-622944:1:exon

position:622944:1
position: 622944
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:623287-624621:1:exon

position:623287:1
position: 623287
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YNL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TOM34
gene: HRB1
locus tag: YNL004W
gene synonym: TOM34
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:14769921]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14676199]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:14769921]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9499403]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9499403]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:24452287]
note: Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication
codon start: 1
product: mRNA-binding protein
translation: MSDQERGSENNNRSRSRSRSPVRRRMSDDHGYERDNHLSRRSGNYNGRRKFADTYRGSRDRGEYRGGRERSDYRERERFNNRDNPRSRDRYDDRRRGRDVTGRYGNRRDDYPRSFRSRHNTRDDSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHHRGMGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDVKSKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYDLFETIGKVNNAELRYDSKGAPTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISYAKRL
SIO_010081: YNL004W
subclass of: SO_0000673
so part of: YNL004W
location: join(622915..622944,623287..624621)
location: region:622915-624621:1
so has part: feature:622915-622944:1:exon
so has part: feature:623287-624621:1:exon

NP_014394.2
type: Protein
SIO_000068: ncbiprotein

S000004949
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:622915-622944:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:623287-624621:1:exon

YNL003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SAM5
gene: PET8
locus tag: YNL003C
gene synonym: SAM5
so part of: sequence
location: complement(<624975..>625829)
location: region:624975-625829:-1
so has part: feature:624975-625829:-1:exon
subclass of: SO_0000010

855729
type: Gene
SIO_000068: ncbigene

position:624975:-1
position: 624975
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:625829:-1
position: 625829
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:624975-625829:-1:exon

YNL003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SAM5
gene: PET8
locus tag: YNL003C
gene synonym: SAM5
product: Pet8p
transcript id: NM_001182842.3
SIO_010081: YNL003C
subclass of: SO_0000673
so part of: YNL003C
location: complement(<624975..>625829)
location: region:624975-625829:-1
so has part: feature:624975-625829:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:624975-625829:-1:exon

YNL003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SAM5
gene: PET8
locus tag: YNL003C
gene synonym: SAM5
experiment: EXISTENCE:direct assay:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14609944|PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]
experiment: EXISTENCE:genetic interaction:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]
experiment: EXISTENCE:genetic interaction:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]
experiment: EXISTENCE:mutant phenotype:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]
experiment: EXISTENCE:mutant phenotype:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]
note: S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
codon start: 1
product: Pet8p
translation: MNTFFLSLLSGAAAGTSTDLVFFPIDTIKTRLQAKGGFFANGGYKGIYRGLGSAVVASAPGASLFFISYDYMKVKSRPYISKLYSQGSEQLIDTTTHMLSSSIGEICACLVRVPAEVVKQRTQVHSTNSSWQTLQSILRNDNKEGLRKNLYRGWSTTIMREIPFTCIQFPLYEYLKKTWAKANGQSQVEPWKGAICGSIAGGIAAATTTPLDFLKTRLMLNKTTASLGSVIIRIYREEGPAVFFSGVGPRTMWISAGGAIFLGMYETVHSLLSKSFPTAGEMRA
SIO_010081: YNL003C
subclass of: SO_0000673
so part of: YNL003C
location: complement(624975..625829)
location: region:624975-625829:-1
so has part: feature:624975-625829:-1:exon

NP_014395.3
type: Protein
SIO_000068: ncbiprotein

S000004948
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:624975-625829:-1:exon

YNL002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL7
gene: RLP7
locus tag: YNL002C
gene synonym: RPL7
so part of: sequence
location: complement(<626174..>627142)
location: region:626174-627142:-1
so has part: feature:626174-627142:-1:exon
subclass of: SO_0000010

855730
type: Gene
SIO_000068: ncbigene

position:626174:-1
position: 626174
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:627142:-1
position: 627142
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:626174-627142:-1:exon

YNL002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL7
gene: RLP7
locus tag: YNL002C
gene synonym: RPL7
product: Rlp7p
transcript id: NM_001182841.3
SIO_010081: YNL002C
subclass of: SO_0000673
so part of: YNL002C
location: complement(<626174..>627142)
location: region:626174-627142:-1
so has part: feature:626174-627142:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:626174-627142:-1:exon

YNL002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL7
gene: RLP7
locus tag: YNL002C
gene synonym: RPL7
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11087857]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:24129494]
experiment: EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]
experiment: EXISTENCE:mutant phenotype:GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11087857]
note: Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA
codon start: 1
product: Rlp7p
translation: MSSTQDSKAQTLNSNPEILLRKRRNADRTRIERQELAKKKREEQIKKKRSNKNKFVRAESIVAKTLATSREKERIKRVSILEDKKAKNETQHIASGKDFILKITEKANGAEENSVDLEETEEEEDDGLIREKTTYDGKPALLFIVRVRGPLAVNIPNKAFKILSLLRLVETNTGVFVKLTKNVYPLLKVIAPYVVIGKPSLSSIRSLIQKRGRIIYKGENEAEPHEIVLNDNNIVEEQLGDHGIICVEDIIHEIATMGESFSVCNFFLQPFKLNREVSGFGSLNRLRKIKQREAESRTRQFSNAATAPVIEVDIDSLLAKLN
SIO_010081: YNL002C
subclass of: SO_0000673
so part of: YNL002C
location: complement(626174..627142)
location: region:626174-627142:-1
so has part: feature:626174-627142:-1:exon

NP_014396.3
type: Protein
SIO_000068: ncbiprotein

S000004947
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:626174-627142:-1:exon

YNL001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DOM34
locus tag: YNL001W
so part of: sequence
location: <627456..>628616
location: region:627456-628616:1
so has part: feature:627456-628616:1:exon
subclass of: SO_0000010

855731
type: Gene
SIO_000068: ncbigene

position:627456:1
position: 627456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:628616:1
position: 628616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:627456-628616:1:exon

YNL001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DOM34
locus tag: YNL001W
product: ribosome dissociation factor DOM34
transcript id: NM_001182840.1
SIO_010081: YNL001W
subclass of: SO_0000673
so part of: YNL001W
location: <627456..>628616
location: region:627456-628616:1
so has part: feature:627456-628616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:627456-628616:1:exon

YNL001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DOM34
locus tag: YNL001W
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:17889667]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:20947765|PMID:24424461]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21623367]
experiment: EXISTENCE:direct assay:GO:1990533 Dom34-Hbs1 complex [PMID:21623367]
experiment: EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:16554824]
experiment: EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:22770215|PMID:24424461]
experiment: EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]
experiment: EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:19420139]
note: Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
codon start: 1
product: ribosome dissociation factor DOM34
translation: MKVISLKKDSFNKGGAVITLLPEDKEDLFTVYQIVDKDDELIFKKKFTSKLDEAGKKKSTDLVKLKIKVISEDFDMKDEYLKYKGVTVTDESGASNVDIPVGKYLSFTLDYVYPFTIIKQNFNKFMQKLLNEACNIEYKSDTAAVVLQEGIAHVCLVTSSSTILKQKIEYSMPKKKRTTDVLKFDEKTEKFYKAIYSAMKKDLNFDKLKTIILCSPGFYAKILMDKIFQYAEEEHNKKILDNKGMFFIAHCSTGYLQGINEVLKNPLYASKLQDTKYSKEIMVMDEFLLHLNKDDDKAWYGEKEVVKAAEYGAISYLLLTDKVLHSDNIAQREEYLKLMDSVESNGGKALVLSTLHSLGEELDQLTGIACILKYPLPDLDEDDGEE
SIO_010081: YNL001W
subclass of: SO_0000673
so part of: YNL001W
location: 627456..628616
location: region:627456-628616:1
so has part: feature:627456-628616:1:exon

NP_014397.1
type: Protein
SIO_000068: ncbiprotein

S000004946
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:627456-628616:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN14; Chromosome XIV centromere
so part of: sequence
location: 628758..628875
location: region:628758-628875:1
so has part: feature:628758-628875:1:region

S000006475
type: SGD
SIO_000068: sgd

position:628758:1
position: 628758
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:628875:1
position: 628875
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628758-628875:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN14_CDEI of CEN14
so part of: sequence
location: 628758..628767
location: region:628758-628767:1
so has part: feature:628758-628767:1:region

position:628767:1
position: 628767
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628758-628767:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN14_CDEII of CEN14
so part of: sequence
location: 628768..628850
location: region:628768-628850:1
so has part: feature:628768-628850:1:region

position:628768:1
position: 628768
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:628850:1
position: 628850
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628768-628850:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN14_CDEIII of CEN14
so part of: sequence
location: 628851..628875
location: region:628851-628875:1
so has part: feature:628851-628875:1:region

position:628851:1
position: 628851
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628851-628875:1:region

YNR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LYS6
gene: CIT1
locus tag: YNR001C
gene synonym: LYS6
so part of: sequence
location: complement(<629622..>631061)
location: region:629622-631061:-1
so has part: feature:629622-631061:-1:exon
subclass of: SO_0000010

855732
type: Gene
SIO_000068: ncbigene

position:629622:-1
position: 629622
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:631061:-1
position: 631061
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:629622-631061:-1:exon

YNR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LYS6
gene: CIT1
locus tag: YNR001C
gene synonym: LYS6
product: citrate (Si)-synthase CIT1
transcript id: NM_001183178.1
SIO_010081: YNR001C
subclass of: SO_0000673
so part of: YNR001C
location: complement(<629622..>631061)
location: region:629622-631061:-1
so has part: feature:629622-631061:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:629622-631061:-1:exon

YNR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LYS6
gene: CIT1
locus tag: YNR001C
gene synonym: LYS6
EC number: 2.3.3.1
experiment: EXISTENCE:direct assay:GO:0004108 citrate (Si)-synthase activity [PMID:17570335]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:11914276|PMID:14576278|PMID:16823961|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]
experiment: EXISTENCE:genetic interaction:GO:0006101 citrate metabolic process [PMID:12913175]
experiment: EXISTENCE:mutant phenotype:GO:0004108 citrate (Si)-synthase activity [PMID:17570335]
experiment: EXISTENCE:mutant phenotype:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]
experiment: EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]
note: Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
codon start: 1
product: citrate (Si)-synthase CIT1
translation: MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQTLKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEGIRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIPEHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLLGKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDYSKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIIDRAVGAPIERPKSFSTEKYKELVKKIESKN
SIO_010081: YNR001C
subclass of: SO_0000673
so part of: YNR001C
location: complement(629622..631061)
location: region:629622-631061:-1
so has part: feature:629622-631061:-1:exon

NP_014398.1
type: Protein
SIO_000068: ncbiprotein

S000005284
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:629622-631061:-1:exon

YNCN0016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF10
locus tag: YNCN0016C
so part of: sequence
location: complement(631846..631917)
location: region:631846-631917:-1
so has part: feature:631846-631917:-1:exon
subclass of: SO_0000663

855734
type: Gene
SIO_000068: ncbigene

position:631846:-1
position: 631846
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:631917:-1
position: 631917
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:631846-631917:-1:exon

YNCN0016C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF10
locus tag: YNCN0016C
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; can mutate to suppress +1 frameshift mutations in proline codons
SIO_010081: YNCN0016C
subclass of: SO_0000673
so part of: YNCN0016C
location: complement(631846..631917)
location: region:631846-631917:-1
so has part: feature:631846-631917:-1:exon

S000006679
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:631846-631917:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(631998..632114)
location: region:631998-632114:-1
so has part: feature:631998-632114:-1:region

S000007143
type: SGD
SIO_000068: sgd

position:631998:-1
position: 631998
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:632114:-1
position: 632114
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:631998-632114:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(632119..632489)
location: region:632119-632489:-1
so has part: feature:632119-632489:-1:region

S000007146
type: SGD
SIO_000068: sgd

position:632119:-1
position: 632119
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:632489:-1
position: 632489
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:632119-632489:-1:region

YNCN0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCN0017W
so part of: sequence
location: 632599..632672
location: region:632599-632672:1
so has part: feature:632599-632672:1:exon
subclass of: SO_0000663

855735
type: Gene
SIO_000068: ncbigene

position:632599:1
position: 632599
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:632672:1
position: 632672
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:632599-632672:1:exon

YNCN0017W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCN0017W
product: tRNA-Asn
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis
SIO_010081: YNCN0017W
subclass of: SO_0000673
so part of: YNCN0017W
location: 632599..632672
location: region:632599-632672:1
so has part: feature:632599-632672:1:exon

S000006674
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:632599-632672:1:exon

YNR002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FUN34
gene: ATO2
locus tag: YNR002C
gene synonym: FUN34
so part of: sequence
location: complement(<633008..>633856)
location: region:633008-633856:-1
so has part: feature:633008-633856:-1:exon
subclass of: SO_0000010

855736
type: Gene
SIO_000068: ncbigene

position:633008:-1
position: 633008
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:633856:-1
position: 633856
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:633008-633856:-1:exon

YNR002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FUN34
gene: ATO2
locus tag: YNR002C
gene synonym: FUN34
product: putative ammonium permease ATO2
transcript id: NM_001183179.3
SIO_010081: YNR002C
subclass of: SO_0000673
so part of: YNR002C
location: complement(<633008..>633856)
location: region:633008-633856:-1
so has part: feature:633008-633856:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:633008-633856:-1:exon

YNR002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FUN34
gene: ATO2
locus tag: YNR002C
gene synonym: FUN34
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17395151]
experiment: EXISTENCE:mutant phenotype:GO:0008519 ammonium transmembrane transporter activity [PMID:12429834]
experiment: EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:12429834]
experiment: EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:12429834]
note: Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
codon start: 1
product: putative ammonium permease ATO2
translation: MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKIYTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTFVLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLSFGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLLAVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPSNDKVFF
SIO_010081: YNR002C
subclass of: SO_0000673
so part of: YNR002C
location: complement(633008..633856)
location: region:633008-633856:-1
so has part: feature:633008-633856:-1:exon

NP_014399.3
type: Protein
SIO_000068: ncbiprotein

S000005285
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:633008-633856:-1:exon

YNR003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPC34
locus tag: YNR003C
so part of: sequence
location: complement(<634344..>635297)
location: region:634344-635297:-1
so has part: feature:634344-635297:-1:exon
subclass of: SO_0000010

855737
type: Gene
SIO_000068: ncbigene

position:634344:-1
position: 634344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:635297:-1
position: 635297
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:634344-635297:-1:exon

YNR003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPC34
locus tag: YNR003C
product: DNA-directed RNA polymerase III subunit C34
transcript id: NM_001183180.1
SIO_010081: YNR003C
subclass of: SO_0000673
so part of: YNR003C
location: complement(<634344..>635297)
location: region:634344-635297:-1
so has part: feature:634344-635297:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:634344-635297:-1:exon

YNR003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPC34
locus tag: YNR003C
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1400451]
experiment: EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]
note: RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
codon start: 1
product: DNA-directed RNA polymerase III subunit C34
translation: MSGMIENGLQLSDNAKTLHSQMMSKGIGALFTQQELQKQMGIGSLTDLMSIVQELLDKNLIKLVKQNDELKFQGVLESEAQKKATMSAEEALVYSYIEASGREGIWSKTIKARTNLHQHVVLKCLKSLESQRYVKSVKSVKFPTRKIYMLYSLQPSVDITGGPWFTDGELDIEFINSLLTIVWRFISENTFPNGFKNFENGPKKNVFYAPNVKNYSTTQEILEFITAAQVANVELTPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMNQGEGEPEAGNKALEDEEEFSIFNYFKMFPASKHDKEVVYFDEWTI
SIO_010081: YNR003C
subclass of: SO_0000673
so part of: YNR003C
location: complement(634344..635297)
location: region:634344-635297:-1
so has part: feature:634344-635297:-1:exon

NP_014400.1
type: Protein
SIO_000068: ncbiprotein

S000005286
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:634344-635297:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1426; Autonomously Replicating Sequence
so part of: sequence
location: 635664..635904
location: region:635664-635904:1
so has part: feature:635664-635904:1:region

S000118392
type: SGD
SIO_000068: sgd

position:635664:1
position: 635664
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:635904:1
position: 635904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:635664-635904:1:region

YNR004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SWM2
locus tag: YNR004W
so part of: sequence
location: <635943..>636383
location: region:635943-636383:1
so has part: feature:635943-636383:1:exon
subclass of: SO_0000010

855738
type: Gene
SIO_000068: ncbigene

position:635943:1
position: 635943
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:636383:1
position: 636383
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:635943-636383:1:exon

YNR004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SWM2
locus tag: YNR004W
product: Swm2p
transcript id: NM_001183181.1
SIO_010081: YNR004W
subclass of: SO_0000673
so part of: YNR004W
location: <635943..>636383
location: region:635943-636383:1
so has part: feature:635943-636383:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:635943-636383:1:exon

YNR004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SWM2
locus tag: YNR004W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]
experiment: EXISTENCE:mutant phenotype:GO:0036261 7-methylguanosine cap hypermethylation [PMID:20621096]
note: Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p
codon start: 1
product: Swm2p
translation: MIDLYNYSNLEGLLDGLTDLNRIPKEYSAVLEPYFQNIARNAHLKSRALKICRSNFHKWNEEGAKTVNPEIIRRCLNLWYVLKGKEYKKLKDPPPADNIIKDEIDVSYVKNLNVVRLEFDEFGKLISNPLENLILEEVEVNDFIQE
SIO_010081: YNR004W
subclass of: SO_0000673
so part of: YNR004W
location: 635943..636383
location: region:635943-636383:1
so has part: feature:635943-636383:1:exon

NP_014401.1
type: Protein
SIO_000068: ncbiprotein

S000005287
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:635943-636383:1:exon

YNR006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DID7
alternative label: GRD11
alternative label: SSV17
alternative label: VPL23
alternative label: VPT27
gene: VPS27
locus tag: YNR006W
gene synonym: DID7; GRD11; SSV17; VPL23; VPT27
so part of: sequence
location: <636986..>638854
location: region:636986-638854:1
so has part: feature:636986-638854:1:exon
subclass of: SO_0000010

855739
type: Gene
SIO_000068: ncbigene

position:636986:1
position: 636986
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:638854:1
position: 638854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:636986-638854:1:exon

YNR006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DID7
alternative label: GRD11
alternative label: SSV17
alternative label: VPL23
alternative label: VPT27
gene: VPS27
locus tag: YNR006W
gene synonym: DID7; GRD11; SSV17; VPL23; VPT27
product: ESCRT-0 subunit protein VPS27
transcript id: NM_001183183.3
SIO_010081: YNR006W
subclass of: SO_0000673
so part of: YNR006W
location: <636986..>638854
location: region:636986-638854:1
so has part: feature:636986-638854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:636986-638854:1:exon

YNR006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DID7
alternative label: GRD11
alternative label: SSV17
alternative label: VPL23
alternative label: VPT27
gene: VPS27
locus tag: YNR006W
gene synonym: DID7; GRD11; SSV17; VPL23; VPT27
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:12055639]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:31740006]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12055639|PMID:20150893]
experiment: EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12055639]
experiment: EXISTENCE:mutant phenotype:GO:0016237 lysosomal microautophagy [PMID:31740006]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12055639]
experiment: EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
experiment: EXISTENCE:physical interaction:GO:0006623 protein targeting to vacuole [PMID:12055639]
experiment: EXISTENCE:physical interaction:GO:0033565 ESCRT-0 complex [PMID:12055639]
note: Ubiquitin binding protein involved in endosomal protein sorting; K48-, K63-Ub chain binding protein that preferentially binds K63-linked chains in vitro; subunit of the ESCRT-0 complex that binds to ubiquitin via two ubiquitin-interacting motifs (UIMs) and is involved in sorting cargo into multivesicular bodies; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation
codon start: 1
product: ESCRT-0 subunit protein VPS27
translation: MSVSTPSELDALIEQATSESIPNGDLDLPIALEISDVLRSRRVNPKDSMRCIKKRILNTADNPNTQLSSWKLTNICVKNGGTPFIKEICSREFMDTMEHVILREDSNEELSELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLTLSNSPTAMFDSKTPADWIDSDACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPLPDLGIYEPVRVCDSCFEDYDLKRHDDSKKSKKHRHKRKKDRDYSTPEDEEELIRKAIELSLKESRNSASSEPIVPVVESKNEVKRQEIEEEEDPDLKAAIQESLREAEEAKLRSERQKASRQMQPQQPSPQPQPIHSVDLSDEEKDSIYMFASLVEKMKSRPLNEILEDSKLQNLAQRVFASKARLNYALNDKAQKYNTLIEMNGKISEIMNIYDRLLEQQLQSINLSQQYTLPQVPSDPYNYLTENVQNPAESYQTPPLQQLSSHQYKPQQDVSRQQSVKANSSPTTNIDHLKTIDVTPHAQQKPQSHVELAPSDPPYPKEEAEDEGTQAVQDEESSTQESRERPYPVETENGETSINKRPQGITRYDFPTVPARKFVQPESTVPLPASSSEIPIKEERPPSPQEELLIEL
SIO_010081: YNR006W
subclass of: SO_0000673
so part of: YNR006W
location: 636986..638854
location: region:636986-638854:1
so has part: feature:636986-638854:1:exon

NP_014403.3
type: Protein
SIO_000068: ncbiprotein

S000005289
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:636986-638854:1:exon

YNR007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG3
alternative label: AUT1
gene: ATG3
locus tag: YNR007C
gene synonym: APG3; AUT1
so part of: sequence
location: complement(<639182..>640114)
location: region:639182-640114:-1
so has part: feature:639182-640114:-1:exon
subclass of: SO_0000010

855741
type: Gene
SIO_000068: ncbigene

position:639182:-1
position: 639182
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:640114:-1
position: 640114
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:639182-640114:-1:exon

YNR007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG3
alternative label: AUT1
gene: ATG3
locus tag: YNR007C
gene synonym: APG3; AUT1
product: Atg3p
transcript id: NM_001183184.3
SIO_010081: YNR007C
subclass of: SO_0000673
so part of: YNR007C
location: complement(<639182..>640114)
location: region:639182-640114:-1
so has part: feature:639182-640114:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:639182-640114:-1:exon

YNR007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG3
alternative label: AUT1
gene: ATG3
locus tag: YNR007C
gene synonym: APG3; AUT1
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:25645919|PMID:25680528]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:15277523]
experiment: EXISTENCE:direct assay:GO:0061908 phagophore [PMID:25645919|PMID:25680528]
experiment: EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:25680528]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:11100732|PMID:15277523]
experiment: EXISTENCE:mutant phenotype:GO:0019776 Atg8 ligase activity [PMID:11100732]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:9023185]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:mutant phenotype:GO:0061908 phagophore [PMID:25680528]
note: E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site
codon start: 1
product: Atg3p
translation: MIRSTLSSWREYLTPITHKSTFLTTGQITPEEFVQAGDYLCHMFPTWKWNEESSDISYRDFLPKNKQFLIIRKVPCDKRAEQCVEVEGPDVIMKGFAEDGDEDDVLEYIGSETEHVQSTPAGGTKDSSIDDIDELIQDMEIKEEDENDDTEEFNAKGGLAKDMAQERYYDLYIAYSTSYRVPKMYIVGFNSNGSPLSPEQMFEDISADYRTKTATIEKLPFYKNSVLSVSIHPCKHANVMKILLDKVRVVRQRRRKELQEEQELDGVGDWEDLQDDIDDSLRVDQYLIVFLKFITSVTPSIQHDYTMEGW
SIO_010081: YNR007C
subclass of: SO_0000673
so part of: YNR007C
location: complement(639182..640114)
location: region:639182-640114:-1
so has part: feature:639182-640114:-1:exon

NP_014404.3
type: Protein
SIO_000068: ncbiprotein

S000005290
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:639182-640114:-1:exon

YNR008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LRO1
locus tag: YNR008W
so part of: sequence
location: <640396..>642381
location: region:640396-642381:1
so has part: feature:640396-642381:1:exon
subclass of: SO_0000010

855742
type: Gene
SIO_000068: ncbigene

position:640396:1
position: 640396
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:642381:1
position: 642381
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:640396-642381:1:exon

YNR008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LRO1
locus tag: YNR008W
product: phospholipid:diacylglycerol acyltransferase
transcript id: NM_001183185.1
SIO_010081: YNR008W
subclass of: SO_0000673
so part of: YNR008W
location: <640396..>642381
location: region:640396-642381:1
so has part: feature:640396-642381:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:640396-642381:1:exon

YNR008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LRO1
locus tag: YNR008W
EC number: 2.3.1.158
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:31422915]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22454508]
experiment: EXISTENCE:direct assay:GO:0006672 ceramide metabolic process [PMID:22738231]
experiment: EXISTENCE:direct assay:GO:0019432 triglyceride biosynthetic process [PMID:10747858]
experiment: EXISTENCE:direct assay:GO:0019915 lipid storage [PMID:10747858]
experiment: EXISTENCE:direct assay:GO:0046027 phospholipid:diacylglycerol acyltransferase activity [PMID:10747858]
experiment: EXISTENCE:direct assay:GO:0055091 phospholipid homeostasis [PMID:31422915]
experiment: EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:22454508]
experiment: EXISTENCE:mutant phenotype:GO:0003824 catalytic activity [PMID:31422915]
experiment: EXISTENCE:mutant phenotype:GO:0006672 ceramide metabolic process [PMID:22738231]
experiment: EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:10747858]
experiment: EXISTENCE:mutant phenotype:GO:0019915 lipid storage [PMID:10747858]
note: Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase
codon start: 1
product: phospholipid:diacylglycerol acyltransferase
translation: MGTLFRRNVQNQKSDSDENNKGGSVHNKRESRNHIHHQQGLGHKRRRGISGSAKRNERGKDFDRKRDGNGRKRWRDSRRLIFILGAFLGVLLPFSFGAYHVHNSDSDLFDNFVNFDSLKVYLDDWKDVLPQGISSFIDDIQAGNYSTSSLDDLSENFAVGKQLLRDYNIEAKHPVVMVPGVISTGIESWGVIGDDECDSSAHFRKRLWGSFYMLRTMVMDKVCWLKHVMLDPETGLDPPNFTLRAAQGFESTDYFIAGYWIWNKVFQNLGVIGYEPNKMTSAAYDWRLAYLDLERRDRYFTKLKEQIELFHQLSGEKVCLIGHSMGSQIIFYFMKWVEAEGPLYGNGGRGWVNEHIDSFINAAGTLLGAPKAVPALISGEMKDTIQLNTLAMYGLEKFFSRIERVKMLQTWGGIPSMLPKGEEVIWGDMKSSSEDALNNNTDTYGNFIRFERNTSDAFNKNLTMKDAINMTLSISPEWLQRRVHEQYSFGYSKNEEELRKNELHHKHWSNPMEVPLPEAPHMKIYCIYGVNNPTERAYVYKEEDDSSALNLTIDYESKQPVFLTEGDGTVPLVAHSMCHKWAQGASPYNPAGINVTIVEMKHQPDRFDIRGGAKSAEHVDILGSAELNDYILKIASGNGDLVEPRQLSNLSQWVSQMPFPM
SIO_010081: YNR008W
subclass of: SO_0000673
so part of: YNR008W
location: 640396..642381
location: region:640396-642381:1
so has part: feature:640396-642381:1:exon

NP_014405.1
type: Protein
SIO_000068: ncbiprotein

S000005291
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:640396-642381:1:exon

YNR009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRM1
locus tag: YNR009W
so part of: sequence
location: <642690..>643439
location: region:642690-643439:1
so has part: feature:642690-643439:1:exon
subclass of: SO_0000010

855743
type: Gene
SIO_000068: ncbigene

position:642690:1
position: 642690
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:643439:1
position: 643439
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:642690-643439:1:exon

YNR009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRM1
locus tag: YNR009W
product: Nrm1p
transcript id: NM_001183186.1
SIO_010081: YNR009W
subclass of: SO_0000673
so part of: YNR009W
location: <642690..>643439
location: region:642690-643439:1
so has part: feature:642690-643439:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:642690-643439:1:exon

YNR009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRM1
locus tag: YNR009W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:16916637]
experiment: EXISTENCE:mutant phenotype:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:16916637]
experiment: EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:16916637]
note: Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase
codon start: 1
product: Nrm1p
translation: MSIMKQRLPLGEFSSSKINKLAIANIADASEPRNHGENNVGTVCLPSIKSLMVSPEVYENTKSLPVPLMRSSGGGMACASKSSCQDGISTKTTSRDYSELSKKLQIRLQFAYYKYKTKQTDKNFTDLKSKHSITRPSKVATHSKSEPLTRRRKLVLSQGHYKTPARSKIKTPSSICSHDNTSSFTSFRGVSESSSTTADMNVADTTTPIRNNINTKHSNSHNRTLYQRQETPTSIKAAKSLIHLFTSNQ
SIO_010081: YNR009W
subclass of: SO_0000673
so part of: YNR009W
location: 642690..643439
location: region:642690-643439:1
so has part: feature:642690-643439:1:exon

NP_014406.1
type: Protein
SIO_000068: ncbiprotein

S000005292
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:642690-643439:1:exon

YNR010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MED9
gene: CSE2
locus tag: YNR010W
gene synonym: MED9
so part of: sequence
location: <643744..>644193
location: region:643744-644193:1
so has part: feature:643744-644193:1:exon
subclass of: SO_0000010

855744
type: Gene
SIO_000068: ncbigene

position:643744:1
position: 643744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:644193:1
position: 644193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:643744-644193:1:exon

YNR010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MED9
gene: CSE2
locus tag: YNR010W
gene synonym: MED9
product: Cse2p
transcript id: NM_001183187.3
SIO_010081: YNR010W
subclass of: SO_0000673
so part of: YNR010W
location: <643744..>644193
location: region:643744-644193:1
so has part: feature:643744-644193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:643744-644193:1:exon

YNR010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MED9
gene: CSE2
locus tag: YNR010W
gene synonym: MED9
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19077037]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:19077037]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9812975]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:19077037]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Cse2p
translation: MNLQNNVLNQIHQILLPTNPTLDKPNAEATKEEFSSAENRDEKDYLTNQQPKNLSTPSTSSNGEFIPHIFYSLHQIRKDPNNLSNQLETLTGSIRHRLKLCKSLISENEDTKDLLSKSPSEWQDIIHQREQELQIKRDVLDDLYRKLQR
SIO_010081: YNR010W
subclass of: SO_0000673
so part of: YNR010W
location: 643744..644193
location: region:643744-644193:1
so has part: feature:643744-644193:1:exon

NP_014407.3
type: Protein
SIO_000068: ncbiprotein

S000005293
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:643744-644193:1:exon

YNR011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RNA2
gene: PRP2
locus tag: YNR011C
gene synonym: RNA2
so part of: sequence
location: complement(<644320..>646950)
location: region:644320-646950:-1
so has part: feature:644320-646950:-1:exon
subclass of: SO_0000010

855745
type: Gene
SIO_000068: ncbigene

position:644320:-1
position: 644320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:646950:-1
position: 646950
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:644320-646950:-1:exon

YNR011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RNA2
gene: PRP2
locus tag: YNR011C
gene synonym: RNA2
product: DEAH-box RNA-dependent ATPase PRP2
transcript id: NM_001183188.1
SIO_010081: YNR011C
subclass of: SO_0000673
so part of: YNR011C
location: complement(<644320..>646950)
location: region:644320-646950:-1
so has part: feature:644320-646950:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:644320-646950:-1:exon

YNR011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RNA2
gene: PRP2
locus tag: YNR011C
gene synonym: RNA2
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:8943336]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:1534753]
experiment: EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:2251118]
experiment: EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:24442613]
note: RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16
codon start: 1
product: DEAH-box RNA-dependent ATPase PRP2
translation: MSSITSETGKRRVKRTYEVTRQNDNAVRIEPSSLGEEEDKEAKDKNSALQLKRSRYDPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKKGLLGDSENETKYASSNSKFNVEVTHKIKNAKEIDKINRQRMWEEQQLRNAMAGQSDHPDDITLEGSDKYDYVFDTDAMIDYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIRFEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTLKLLISSATMNAKKFSEFFDNCPIFNVPGRRYPVDIHYTLQPEANYIHAAITTIFQIHTTQSLPGDILVFLTGQEEIERTKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQPTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETPSLFIGQKRDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFKTMLRVRNIRNQLFRCSEKVGLVEKNDQARMKIGNIAGYINARITRCFISGFPMNIVQLGPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQLMLTSKEFIRDCLVIPKEEWLIDMVPQIFKDLIDDKTNRGRR
SIO_010081: YNR011C
subclass of: SO_0000673
so part of: YNR011C
location: complement(644320..646950)
location: region:644320-646950:-1
so has part: feature:644320-646950:-1:exon

NP_014408.1
type: Protein
SIO_000068: ncbiprotein

S000005294
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:644320-646950:-1:exon

YNR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: URK1
locus tag: YNR012W
so part of: sequence
location: <647432..>648937
location: region:647432-648937:1
so has part: feature:647432-648937:1:exon
subclass of: SO_0000010

855746
type: Gene
SIO_000068: ncbigene

position:647432:1
position: 647432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:648937:1
position: 648937
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:647432-648937:1:exon

YNR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: URK1
locus tag: YNR012W
product: uridine kinase URK1
transcript id: NM_001183189.1
SIO_010081: YNR012W
subclass of: SO_0000673
so part of: YNR012W
location: <647432..>648937
location: region:647432-648937:1
so has part: feature:647432-648937:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:647432-648937:1:exon

YNR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: URK1
locus tag: YNR012W
EC number: 2.7.1.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004849 uridine kinase activity [PMID:10501935]
experiment: EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:11872485]
note: Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
codon start: 1
product: uridine kinase URK1
translation: MSHRIAPSKERSSSFISILDDETRDTLKANAVMDGEVDVKKTKGKSSRYIPPWTTPYIIGIGGASGSGKTSVAAKIVSSINVPWTVLISLDNFYNPLGPEDRARAFKNEYDFDEPNAINLDLAYKCILNLKEGKRTNIPVYSFVHHNRVPDKNIVIYGASVVVIEGIYALYDRRLLDLMDLKIYVDADLDVCLARRLSRDIVSRGRDLDGCIQQWEKFVKPNAVKFVKPTMKNADAIIPSMSDNATAVNLIINHIKSKLELKSNEHLRELIKLGSSPSQDVLNRNIIHELPPTNQVLSLHTMLLNKNLNCADFVFYFDRLATILLSWALDDIPVAHTNIITPGEHTMENVIACQFDQVTAVNIIRSGDCFMKSLRKTIPNITIGKLLIQSDSQTGEPQLHCEFLPPNIEKFGKVFLMEGQIISGAAMIMAIQVLLDHGIDLEKISVVVYLATEVGIRRILNAFDNKVNIFAGMIISREKLQNHQYKWALTRFFDSKYFGCD
SIO_010081: YNR012W
subclass of: SO_0000673
so part of: YNR012W
location: 647432..648937
location: region:647432-648937:1
so has part: feature:647432-648937:1:exon

NP_014409.1
type: Protein
SIO_000068: ncbiprotein

S000005295
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:647432-648937:1:exon

YNR013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHO91
locus tag: YNR013C
so part of: sequence
location: complement(<649028..>651712)
location: region:649028-651712:-1
so has part: feature:649028-651712:-1:exon
subclass of: SO_0000010

855747
type: Gene
SIO_000068: ncbigene

position:649028:-1
position: 649028
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:651712:-1
position: 651712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:649028-651712:-1:exon

YNR013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHO91
locus tag: YNR013C
product: Pho91p
transcript id: NM_001183190.3
SIO_010081: YNR013C
subclass of: SO_0000673
so part of: YNR013C
location: complement(<649028..>651712)
location: region:649028-651712:-1
so has part: feature:649028-651712:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:649028-651712:-1:exon

YNR013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHO91
locus tag: YNR013C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17804816]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]
experiment: EXISTENCE:genetic interaction:GO:0005315 inorganic phosphate transmembrane transporter activity [PMID:11779791]
experiment: EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]
experiment: EXISTENCE:genetic interaction:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]
experiment: EXISTENCE:genetic interaction:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]
experiment: EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]
experiment: EXISTENCE:mutant phenotype:GO:0005315 inorganic phosphate transmembrane transporter activity [PMID:12581367]
experiment: EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]
experiment: EXISTENCE:mutant phenotype:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]
experiment: EXISTENCE:mutant phenotype:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]
note: Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
codon start: 1
product: Pho91p
translation: MKFSHSLQFNSVPEWSTKYLAYSQLKKLIYSLQKDKLYSNNKHHVVEPHDANDENLPLLADASPDDQFYISKFVAALNQELKKIDKFYISQETGLIANYNELKDDVMELENTNKATQLFNQQQQHQLQSVARNRKSKSQQRQRRFSSVSSTDSNPSLTDMSIDSAPVIHTQVSNTTNNGNSMQNLASASVSLSNSNPVYLSPFTQHRLSLKKRLISIYTQLSELKDFIELNQTGFSKICKKFDKSLNTNLKQNYLNYIKFHSHVFNPATINRIQHHITETILTYASLNKGTRRPSNTFNLDADRINNDENSSGNEEDEDGNRQEVLDFQDAERELSSHLRDHVVWERNTVWKDMMNLERKYQSAKTDNKKFSKLSSSQLRPNANITESMAMSSGGAGIIAPSTDSLTFRELMHLPPKQWLQFIMGQTSLLKFLLITSCFIALLTFNLTPFTQDSLQKNCFAILIYASLLWATETIPLFVTSLMIPLLIVVFPVIKDPITSQPMSPRDSSQFILSTMWSSVIMLLLGGFTLAAALSKYNIAKVLSTHILASAGTNPHFILLTNMFVALFVSMWVSNVAAPVLCYSIVQPLLRTLPRNCSYAKALILGIALASNIGGMSSPIASPQNIFSIGIMDPSPSWAEWFMIALPVCFICVMAIWVLLIITFPPEPNVKILQLHPSRDPFTLKQWFVTLVCIITIVLWCLSNQISGIFGEMGIISIIPIVVFFGTGLLTSDDFNNFMWTIVVLAMGGTTLGKAVSSSGLLSTMAQLIKAQVEHEPIFIIVLIFGLVILVMATFVSHTVAAMIIVPLMSEIGSNLPSGDHSRLLIVIAALLCSSAMGLPTSGFPNVTAISMIDEVGDRYLTVGTFITRGVPASLLSYAAIVTVGYGILKVMGF
SIO_010081: YNR013C
subclass of: SO_0000673
so part of: YNR013C
location: complement(649028..651712)
location: region:649028-651712:-1
so has part: feature:649028-651712:-1:exon

NP_014410.3
type: Protein
SIO_000068: ncbiprotein

S000005296
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:649028-651712:-1:exon

YNR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNR014W
so part of: sequence
location: <652465..>653103
location: region:652465-653103:1
so has part: feature:652465-653103:1:exon
subclass of: SO_0000010

855748
type: Gene
SIO_000068: ncbigene

position:652465:1
position: 652465
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:653103:1
position: 653103
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:652465-653103:1:exon

YNR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YNR014W
product: uncharacterized protein
transcript id: NM_001183191.3
SIO_010081: YNR014W
subclass of: SO_0000673
so part of: YNR014W
location: <652465..>653103
location: region:652465-653103:1
so has part: feature:652465-653103:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:652465-653103:1:exon

YNR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YNR014W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
note: hypothetical protein; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSSTDIKPCAVNIPVSAHITFHYKSIADRSSSRSSSSSSCSSATSKACSPRGSSVGLPPALSTDNEIVETVLNVSAPVVADPTRPSLFKSNYTAASCLTSDPTSPSLLPSSRRNSVLPASDFHQCAHHKNFQRRASEPQLPSFDNRSSSEMKRSVSYAQHSMMFPISDQQEPQTSASPNDHSDPSCPCNRHHHRRNSVAVKFDKPLYERLET
SIO_010081: YNR014W
subclass of: SO_0000673
so part of: YNR014W
location: 652465..653103
location: region:652465-653103:1
so has part: feature:652465-653103:1:exon

NP_014411.3
type: Protein
SIO_000068: ncbiprotein

S000005297
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:652465-653103:1:exon

YNR015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DUS2
gene: SMM1
locus tag: YNR015W
gene synonym: DUS2
so part of: sequence
location: <653387..>654541
location: region:653387-654541:1
so has part: feature:653387-654541:1:exon
subclass of: SO_0000010

855749
type: Gene
SIO_000068: ncbigene

position:653387:1
position: 653387
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:654541:1
position: 654541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:653387-654541:1:exon

YNR015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DUS2
gene: SMM1
locus tag: YNR015W
gene synonym: DUS2
product: tRNA-dihydrouridine(20) synthase (NAD(+))
transcript id: NM_001183192.1
SIO_010081: YNR015W
subclass of: SO_0000673
so part of: YNR015W
location: <653387..>654541
location: region:653387-654541:1
so has part: feature:653387-654541:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:653387-654541:1:exon