Saccharomyces cerevisiae S288C chromosome XIII, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome XIII, complete sequence.
sequence version: NC_001145.3
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001145.3
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169872
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006946.\n\nOn Apr 26, 2011 this sequence version replaced NC_001145.2.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##

sequence
subclass of: SO_0000340
sequence length: 924431
topology: linear
so has quality: SO_0000987
location: 1..924431
location: region:1-924431:1
RO_0002162: 559292

NC_001145
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII
author: Bowman, S.
author: Churcher, C.
author: Badcock, K.
author: Brown, D.
author: Chillingworth, T.
author: Connor, R.
author: Dedman, K.
author: Devlin, K.
author: Gentles, S.
author: Hamlin, N.
author: Hunt, S.
author: Jagels, K.
author: Lye, G.
author: Moule, S.
author: Odell, C.
author: Pearson, D.
author: Rajandream, M.
author: Rice, P.
author: Skelton, J.
author: Walsh, S.
author: Whitehead, S.
author: Barrell, B.
journal: Nature 387 (6632 SUPPL), 90-93 (1997)
pubmed: 9169872

9169872
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

7
title: Direct Submission
journal: Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:924431:1
position: 924431
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-924431:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: XIII

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL13L; Telomeric region on the left arm of Chromosome XIII; composed of an X element core sequence, X element combinatorial repeats, a short region of telomeric repeats, a short Y' element, and a short terminal region of telomeric repeats
so part of: sequence
location: complement(1..6344)
location: region:1-6344:-1
so has part: feature:1-6344:-1:region

S000028918
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:6344:-1
position: 6344
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-6344:-1:region

YML133C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML133C
so part of: sequence
location: complement(<461..>4684)
location: region:461-4684:-1
so has part: feature:461-4684:-1:exon
subclass of: SO_0000010

854906
type: Gene
SIO_000068: ncbigene

position:461:-1
position: 461
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:4684:-1
position: 4684
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:461-4684:-1:exon

YML133C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML133C
product: Y' element ATP-dependent helicase
transcript id: NM_001182496.1
SIO_010081: YML133C
subclass of: SO_0000673
so part of: YML133C
location: complement(join(<461..3791,3891..>4684))
location: region:461-4684:-1
so has part: feature:3891-4684:-1:exon
so has part: feature:461-3791:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:3891-4684:-1:exon

position:3891:-1
position: 3891
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:461-3791:-1:exon

position:3791:-1
position: 3791
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML133C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML133C
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
codon start: 1
product: Y' element ATP-dependent helicase
translation: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRRYGYNLAPHMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYNKNSSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWVDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
SIO_010081: YML133C
subclass of: SO_0000673
so part of: YML133C
location: complement(join(461..3791,3891..4684))
location: region:461-4684:-1
so has part: feature:3891-4684:-1:exon
so has part: feature:461-3791:-1:exon

NP_013573.1
type: Protein
SIO_000068: ncbiprotein

S000004602
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:3891-4684:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:461-3791:-1:exon

YML132W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS3
locus tag: YML132W
so part of: sequence
location: <7244..>8383
location: region:7244-8383:1
so has part: feature:7244-8383:1:exon
subclass of: SO_0000010

854907
type: Gene
SIO_000068: ncbigene

position:7244:1
position: 7244
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:8383:1
position: 8383
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7244-8383:1:exon

YML132W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS3
locus tag: YML132W
product: Cos3p
transcript id: NM_001182495.1
SIO_010081: YML132W
subclass of: SO_0000673
so part of: YML132W
location: <7244..>8383
location: region:7244-8383:1
so has part: feature:7244-8383:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:7244-8383:1:exon

YML132W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS3
locus tag: YML132W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14718542|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14718542]
experiment: EXISTENCE:mutant phenotype:GO:0006883 cellular sodium ion homeostasis [PMID:14718542]
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
codon start: 1
product: Cos3p
translation: MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSNNCIYPLIVSLLVLFLGPIFVLVICGLSRKRSLSKQLIQFCKEITENTPSSDPHDWEVVAANLNSYLYENNVWNTKYFFFNAMVCQEAFRTTLLEPFSLKKDKAAKVKSFKDSVPYIEEALGVYFTEVEKQWKLFNTEKSWSPVGLEDAKLPKEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTLYLGWILFMLVQGFQNIRVLIMSMEHKMQFLSTIINEQESGANGWDEIARKMNRYLFEKKAWKNEEFFFDGIDCEWFFNHFFYRVLSAKKSMWPLPLNVELWPYIKEAQLSRSEVLLV
SIO_010081: YML132W
subclass of: SO_0000673
so part of: YML132W
location: 7244..8383
location: region:7244-8383:1
so has part: feature:7244-8383:1:exon

NP_013574.1
type: Protein
SIO_000068: ncbiprotein

S000004601
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:7244-8383:1:exon

YML131W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML131W
so part of: sequence
location: <10198..>11295
location: region:10198-11295:1
so has part: feature:10198-11295:1:exon
subclass of: SO_0000010

854908
type: Gene
SIO_000068: ncbigene

position:10198:1
position: 10198
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:11295:1
position: 11295
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:10198-11295:1:exon

YML131W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML131W
product: uncharacterized protein
transcript id: NM_001182494.1
SIO_010081: YML131W
subclass of: SO_0000673
so part of: YML131W
location: <10198..>11295
location: region:10198-11295:1
so has part: feature:10198-11295:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:10198-11295:1:exon

YML131W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML131W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MVLAKQWVLKNLPTPGEPFNFHFHDPACTFELIEKELSSEQLKDGELLLETTYLSNDPAQKFWISSMDKNYAKGVQPGEIIPARGIGKVLASRNKAFSPGDYVSAVTGWTTHAIISQENVQGLRKLDKNKVGKLWWYLSVLGGTSLTAYFIFFTYAQLQEREEDYGKVYLISGAAGAVGTVCIQLALNVFKASKVIAIAGGPEKVAFVESFGDNVVGVDYKDPSFKQKLIEAAGGENTVDYFIDNVGSNVLEAGVLLLKQRAMLIACGAISAYNDPSKFVFKGYSFILTKRLVVKGVLVTDNIDDFPKALDKLGSLVKHGKIDLLKSATLEDGTGDKFKNVPLIWKGLFSGVNKGKLITKVNNEE
SIO_010081: YML131W
subclass of: SO_0000673
so part of: YML131W
location: 10198..11295
location: region:10198-11295:1
so has part: feature:10198-11295:1:exon

NP_013575.1
type: Protein
SIO_000068: ncbiprotein

S000004600
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:10198-11295:1:exon

YML130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERO1
locus tag: YML130C
so part of: sequence
location: complement(<11483..>13174)
location: region:11483-13174:-1
so has part: feature:11483-13174:-1:exon
subclass of: SO_0000010

854909
type: Gene
SIO_000068: ncbigene

position:11483:-1
position: 11483
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:13174:-1
position: 13174
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11483-13174:-1:exon

YML130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERO1
locus tag: YML130C
product: ER oxidoreductin
transcript id: NM_001182493.1
SIO_010081: YML130C
subclass of: SO_0000673
so part of: YML130C
location: complement(<11483..>13174)
location: region:11483-13174:-1
so has part: feature:11483-13174:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11483-13174:-1:exon

YML130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERO1
locus tag: YML130C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:9659914|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:16407158]
experiment: EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:9659913]
note: Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L
codon start: 1
product: ER oxidoreductin
translation: MRLRTAIATLCLTAFTSATSNNSYIATDQTQNAFNDTHFCKVDRNDHVSPSCNVTFNELNAINENIRDDLSALLKSDFFKYFRLDLYKQCSFWDANDGLCLNRACSVDVVEDWDTLPEYWQPEILGSFNNDTMKEADDSDDECKFLDQLCQTSKKPVDIEDTINYCDVNDFNGKNAVLIDLTANPERFTGYGGKQAGQIWSTIYQDNCFTIGETGESLAKDAFYRLVSGFHASIGTHLSKEYLNTKTGKWEPNLDLFMARIGNFPDRVTNMYFNYAVVAKALWKIQPYLPEFSFCDLVNKEIKNKMDNVISQLDTKIFNEDLVFANDLSLTLKDEFRSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDADEFTKQHIVGKLTKYELIALLQTFGRLSESIESVNMFEKMYGKRLNGSENRLSSFFQNNFFNILKEAGKSIRYTIENINSTKEGKKKTNNSQSHVFDDLKMPKAEIVPRPSNGTVNKWKKAWNTEVNNVLEAFRFIYRSYLDLPRNIWELSLMKVYKFWNKFIGVADYVSEETREPISYKLDIQ
SIO_010081: YML130C
subclass of: SO_0000673
so part of: YML130C
location: complement(11483..13174)
location: region:11483-13174:-1
so has part: feature:11483-13174:-1:exon

NP_013576.1
type: Protein
SIO_000068: ncbiprotein

S000004599
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11483-13174:-1:exon

YML129C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX14
locus tag: YML129C
so part of: sequence
location: complement(<14541..>14753)
location: region:14541-14753:-1
so has part: feature:14541-14753:-1:exon
subclass of: SO_0000010

854910
type: Gene
SIO_000068: ncbigene

position:14541:-1
position: 14541
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14753:-1
position: 14753
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14541-14753:-1:exon

YML129C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX14
locus tag: YML129C
product: Cox14p
transcript id: NM_001182492.1
SIO_010081: YML129C
subclass of: SO_0000673
so part of: YML129C
location: complement(<14541..>14753)
location: region:14541-14753:-1
so has part: feature:14541-14753:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14541-14753:-1:exon

YML129C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX14
locus tag: YML129C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:7797555]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15306853]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15306853]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:21068384|PMID:7797555]
experiment: EXISTENCE:physical interaction:GO:0070130 negative regulation of mitochondrial translation [PMID:15306853]
note: Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane
codon start: 1
product: Cox14p
translation: MSKYAWYTRVTDTLHRLTVLTLVGGTLYMSGGLAYTLYMNGKKYEQQVTQQKALEEDNQQLQSPTAPPTE
SIO_010081: YML129C
subclass of: SO_0000673
so part of: YML129C
location: complement(14541..14753)
location: region:14541-14753:-1
so has part: feature:14541-14753:-1:exon

NP_013577.1
type: Protein
SIO_000068: ncbiprotein

S000004598
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14541-14753:-1:exon

YML128C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSC1
locus tag: YML128C
so part of: sequence
location: complement(<15135..>16676)
location: region:15135-16676:-1
so has part: feature:15135-16676:-1:exon
subclass of: SO_0000010

854911
type: Gene
SIO_000068: ncbigene

position:15135:-1
position: 15135
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:16676:-1
position: 16676
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:15135-16676:-1:exon

YML128C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSC1
locus tag: YML128C
product: Msc1p
transcript id: NM_001182491.1
SIO_010081: YML128C
subclass of: SO_0000673
so part of: YML128C
location: complement(<15135..>16676)
location: region:15135-16676:-1
so has part: feature:15135-16676:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:15135-16676:-1:exon

YML128C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSC1
locus tag: YML128C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]
note: hypothetical protein; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
codon start: 1
product: Msc1p
translation: MKQFKLVNAVSASFVLIGLVLANSDSVFDKWTQEDLADYLRDNKKSLEKYATDSIEDLKTEASQVWDKHAQPKPWWQVWSSDSSSVSNSNPGWFGYTGSSDHPVSDWLFDTWSTDSLRNFLKKNGVDVDDAKASKDSLVKTAKENFNKISKSLKSSGYYPSSSYFDSWSTKDLQNWLNDNGIDYDKAVQSKDELVQKVKENIYRTSEKAEQQRLGLLESLDLAHQQILDTSGQIKDTVFDKWSSDQLTNWLESHKVNIDKNMAKKHDYLVRMAKENSANLKDDIYWYLDYMKRESSPFLTKTPEYVGSVWDSSKNFLTNLYSKFRGKTDNVINDTFLVGLDSWPKDKLKMFLDARGIKYSMLSTEHQLRELVKKSRNEKLKILPKDYQKYFDNSNWSLDDIKGWFADKKDDFQDSQTYSTIMQDFDKVSKNTNDAKDQIAKTWSNTFQSWSQEDLLQYLKSFGVPVKQTSTKDDLINLAKQNTQWLFGTVKEPAYKRYLHNVKNWSKSILGFN
SIO_010081: YML128C
subclass of: SO_0000673
so part of: YML128C
location: complement(15135..16676)
location: region:15135-16676:-1
so has part: feature:15135-16676:-1:exon

NP_013578.1
type: Protein
SIO_000068: ncbiprotein

S000004597
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:15135-16676:-1:exon

YML127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSC9
locus tag: YML127W
so part of: sequence
location: <17064..>18809
location: region:17064-18809:1
so has part: feature:17064-18809:1:exon
subclass of: SO_0000010

854912
type: Gene
SIO_000068: ncbigene

position:17064:1
position: 17064
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:18809:1
position: 18809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17064-18809:1:exon

YML127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSC9
locus tag: YML127W
product: Rsc9p
transcript id: NM_001182490.1
SIO_010081: YML127W
subclass of: SO_0000673
so part of: YML127W
location: <17064..>18809
location: region:17064-18809:1
so has part: feature:17064-18809:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17064-18809:1:exon

YML127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSC9
locus tag: YML127W
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:11931764]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:11931764|PMID:12183366]
experiment: EXISTENCE:direct assay:GO:0070301 cellular response to hydrogen peroxide [PMID:11931764]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11931764]
experiment: EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:11931764]
note: Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
codon start: 1
product: Rsc9p
translation: MNSLASNTPLNGTPVSEAPATSSEPVNMFETMVANPIKVSRLQSNGVLTGPAANTKSIHYSLANFNVFQSLPKETARGVDDLTRMEMALLSGIPEEIKWSLKKYLTYSNKAPYMISLRTLPDLLPLFKTFILPLERIVEGLNKSSICDSKAMDSLQMGLNALLILRNLAQDTDSVQILVKDREIKSFILFILKKFQCVATGDNKWQLYEGNATFFNELTHYTLDLMEAISSYIAPAMKDDHYFQTLVSILNYTKDRYMVISILRSLSRLLVRSKANEESAADNLDHKTLSLIVSFLLLECDSELIIASLDFLYQYILPGSQRITELFKSKECSLILEATLPNLLSYNIATPDYHLLQKHKIRLIKRLKPPAPKEPPNLSEDLFQQLFKLNEPLRSTAWLRCCFEPVQEAEFTQISLWRSYESKFGQPVRESGRKLLPAVEFIKNVSNAFNNAAAIVITDPVTGKKRFVIKGIQPRFKALGIADGERESQVPISALKSKFLNDSKEITPARQNSIPEVKFPQELSDVSKVACTFLCLLSNDTDDGAGSAFCQRIRPLVLHKLADIPPLTLALSEYMENTSGL
SIO_010081: YML127W
subclass of: SO_0000673
so part of: YML127W
location: 17064..18809
location: region:17064-18809:1
so has part: feature:17064-18809:1:exon

NP_013579.1
type: Protein
SIO_000068: ncbiprotein

S000004596
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17064-18809:1:exon

YML126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HMGS
gene: ERG13
locus tag: YML126C
gene synonym: HMGS
so part of: sequence
location: complement(<19060..>20535)
location: region:19060-20535:-1
so has part: feature:19060-20535:-1:exon
subclass of: SO_0000010

854913
type: Gene
SIO_000068: ncbigene

position:19060:-1
position: 19060
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:20535:-1
position: 20535
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:19060-20535:-1:exon

YML126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HMGS
gene: ERG13
locus tag: YML126C
gene synonym: HMGS
product: hydroxymethylglutaryl-CoA synthase
transcript id: NM_001182489.1
SIO_010081: YML126C
subclass of: SO_0000673
so part of: YML126C
location: complement(<19060..>20535)
location: region:19060-20535:-1
so has part: feature:19060-20535:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:19060-20535:-1:exon

YML126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HMGS
gene: ERG13
locus tag: YML126C
gene synonym: HMGS
EC number: 2.3.3.10
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004421 hydroxymethylglutaryl-CoA synthase activity [PMID:6148937|PMID:12702274]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:6148937|PMID:12702274]
note: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
codon start: 1
product: hydroxymethylglutaryl-CoA synthase
translation: MKLSTKLCWCGIKGRLRPQKQQQLHNTNLQMTELKKQKTAEQKTRPQNVGIKGIQIYIPTQCVNQSELEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTETLIDKSKSVKSVLMQLFGENTDVEGIDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVCGDIAIYDKGAARPTGGAGTVAMWIGPDAPIVFDSVRASYMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSYGRLLYNDFRANPQLFPEVDAELATRDYDESLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKELDITNKLAKRITETPKDYEAAIELRENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDVKK
SIO_010081: YML126C
subclass of: SO_0000673
so part of: YML126C
location: complement(19060..20535)
location: region:19060-20535:-1
so has part: feature:19060-20535:-1:exon

NP_013580.1
type: Protein
SIO_000068: ncbiprotein

S000004595
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:19060-20535:-1:exon

YML125C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NQR1
gene: PGA3
locus tag: YML125C
gene synonym: NQR1
so part of: sequence
location: complement(<20761..>21699)
location: region:20761-21699:-1
so has part: feature:20761-21699:-1:exon
subclass of: SO_0000010

854914
type: Gene
SIO_000068: ncbigene

position:20761:-1
position: 20761
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:21699:-1
position: 21699
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:20761-21699:-1:exon

YML125C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NQR1
gene: PGA3
locus tag: YML125C
gene synonym: NQR1
product: cytochrome-b5 reductase
transcript id: NM_001182488.1
SIO_010081: YML125C
subclass of: SO_0000673
so part of: YML125C
location: complement(<20761..>21699)
location: region:20761-21699:-1
so has part: feature:20761-21699:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:20761-21699:-1:exon

YML125C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NQR1
gene: PGA3
locus tag: YML125C
gene synonym: NQR1
EC number: 1.6.2.2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19239415]
experiment: EXISTENCE:mutant phenotype:GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H [PMID:19239415]
experiment: EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:16943325]
note: Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication
codon start: 1
product: cytochrome-b5 reductase
translation: MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILWSLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLDIPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDTVDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETENDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLLICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF
SIO_010081: YML125C
subclass of: SO_0000673
so part of: YML125C
location: complement(20761..21699)
location: region:20761-21699:-1
so has part: feature:20761-21699:-1:exon

NP_013581.1
type: Protein
SIO_000068: ncbiprotein

S000004594
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:20761-21699:-1:exon

YML124C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TUB3
locus tag: YML124C
so part of: sequence
location: complement(<22048..>23683)
location: region:22048-23683:-1
so has part: feature:22048-23683:-1:exon
subclass of: SO_0000010

854915
type: Gene
SIO_000068: ncbigene

position:22048:-1
position: 22048
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:23683:-1
position: 23683
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22048-23683:-1:exon

YML124C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TUB3
locus tag: YML124C
product: alpha-tubulin TUB3
transcript id: NM_001182487.1
SIO_010081: YML124C
subclass of: SO_0000673
so part of: YML124C
location: complement(join(<22048..23360,23659..>23683))
location: region:22048-23683:-1
so has part: feature:23659-23683:-1:exon
so has part: feature:22048-23360:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:23659-23683:-1:exon

position:23659:-1
position: 23659
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:22048-23360:-1:exon

position:23360:-1
position: 23360
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML124C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TUB3
locus tag: YML124C
experiment: EXISTENCE:curator inference:GO:0000070 mitotic sister chromatid segregation [PMID:3540600]
experiment: EXISTENCE:curator inference:GO:0005828 kinetochore microtubule [PMID:3540600]
experiment: EXISTENCE:curator inference:GO:0005880 nuclear microtubule [PMID:3540600]
experiment: EXISTENCE:curator inference:GO:0005881 cytoplasmic microtubule [PMID:3540600]
experiment: EXISTENCE:curator inference:GO:0030473 nuclear migration along microtubule [PMID:3540600]
experiment: EXISTENCE:curator inference:GO:0045143 homologous chromosome segregation [PMID:3540600]
experiment: EXISTENCE:direct assay:GO:0005819 spindle [PMID:24390141]
experiment: EXISTENCE:genetic interaction:GO:0045298 tubulin complex [PMID:3540600]
experiment: EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:10793159]
note: Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
codon start: 1
product: alpha-tubulin TUB3
translation: MREVISINVGQAGCQIGNACWELYSLEHGIKEDGHLEDGLSKPKGGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRTGRFKELFHPEQLINGKEDAANNYARGHYTVGREIVDEVEERIRKMADQCDGLQGFLFTHSLGGGTGSGLGSLLLENLSYEYGKKSKLEFAVYPAPQLSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDICKRNLGISRPSFSNLNGLIAQVISSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPILSKKRATHESNSVSEITNACFEPGNQMVKCDPTKGKYMANCLLYRGDVVTRDVQRAVEQVKNKKTVQMVDWCPTGFKIGICYEPPSVIPSSELANVDRAVCMLSNTTAIADAWKRIDQKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEF
SIO_010081: YML124C
subclass of: SO_0000673
so part of: YML124C
location: complement(join(22048..23360,23659..23683))
location: region:22048-23683:-1
so has part: feature:23659-23683:-1:exon
so has part: feature:22048-23360:-1:exon

NP_013582.1
type: Protein
SIO_000068: ncbiprotein

S000004593
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:23659-23683:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:22048-23360:-1:exon

YNCM0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0001W
so part of: sequence
location: 23564..26578
location: region:23564-26578:1
so has part: feature:23564-26578:1:exon
subclass of: SO_0000011

65052917
type: Gene
SIO_000068: ncbigene

position:23564:1
position: 23564
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:26578:1
position: 26578
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:23564-26578:1:exon

YNCM0001W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: antisense_RNA
locus tag: YNCM0001W
product: PHO84 lncRNA
note: Antisense to PHO84 and beginning of YML122C; represses transcription of PHO84 through histone deacetylation
transcript id: NR_172477.1
SIO_010081: YNCM0001W
subclass of: SO_0000673
so part of: YNCM0001W
location: 23564..26578
location: region:23564-26578:1
so has part: feature:23564-26578:1:exon

S000303814
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:23564-26578:1:exon

YML123C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHO84
locus tag: YML123C
so part of: sequence
location: complement(<24037..>25800)
location: region:24037-25800:-1
so has part: feature:24037-25800:-1:exon
subclass of: SO_0000010

854916
type: Gene
SIO_000068: ncbigene

position:24037:-1
position: 24037
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25800:-1
position: 25800
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:24037-25800:-1:exon

YML123C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHO84
locus tag: YML123C
product: phosphate transporter PHO84
transcript id: NM_001182486.1
SIO_010081: YML123C
subclass of: SO_0000673
so part of: YML123C
location: complement(<24037..>25800)
location: region:24037-25800:-1
so has part: feature:24037-25800:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:24037-25800:-1:exon

YML123C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHO84
locus tag: YML123C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005315 inorganic phosphate transmembrane transporter activity [PMID:7851439]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2038328]
experiment: EXISTENCE:direct assay:GO:0006817 phosphate ion transport [PMID:7851439]
experiment: EXISTENCE:direct assay:GO:0097079 selenite:proton symporter activity [PMID:20688911]
experiment: EXISTENCE:mutant phenotype:GO:0005315 inorganic phosphate transmembrane transporter activity [PMID:2038328]
experiment: EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:12923174]
experiment: EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]
experiment: EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:2038328]
experiment: EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:12923174]
experiment: EXISTENCE:mutant phenotype:GO:0097079 selenite:proton symporter activity [PMID:20688911]
experiment: EXISTENCE:mutant phenotype:GO:0097080 plasma membrane selenite transport [PMID:20688911]
note: High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
codon start: 1
product: phosphate transporter PHO84
translation: MSSVNKDTIHVAERSLHKEHLTEGGNMAFHNHLNDFAHIEDPLERRRLALESIDDEGFGWQQVKTISIAGVGFLTDSYDIFAINLGITMMSYVYWHGSMPGPSQTLLKVSTSVGTVIGQFGFGTLADIVGRKRIYGMELIIMIVCTILQTTVAHSPAINFVAVLTFYRIVMGIGIGGDYPLSSIITSEFATTKWRGAIMGAVFANQAWGQISGGIIALILVAAYKGELEYANSGAECDARCQKACDQMWRILIGLGTVLGLACLYFRLTIPESPRYQLDVNAKLELAAAAQEQDGEKKIHDTSDEDMAINGLERASTAVESLDNHPPKASFKDFCRHFGQWKYGKILLGTAGSWFTLDVAFYGLSLNSAVILQTIGYAGSKNVYKKLYDTAVGNLILICAGSLPGYWVSVFTVDIIGRKPIQLAGFIILTALFCVIGFAYHKLGDHGLLALYVICQFFQNFGPNTTTFIVPGECFPTRYRSTAHGISAASGKVGAIIAQTALGTLIDHNCARDGKPTNCWLPHVMEIFALFMLLGIFTTLLIPETKRKTLEEINELYHDEIDPATLNFRNKNNDIESSSPSQLQHEA
SIO_010081: YML123C
subclass of: SO_0000673
so part of: YML123C
location: complement(24037..25800)
location: region:24037-25800:-1
so has part: feature:24037-25800:-1:exon

NP_013583.1
type: Protein
SIO_000068: ncbiprotein

S000004592
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:24037-25800:-1:exon

YML122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML122C
so part of: sequence
location: complement(<26038..>26418)
location: region:26038-26418:-1
so has part: feature:26038-26418:-1:exon
subclass of: SO_0000010

854917
type: Gene
SIO_000068: ncbigene

position:26038:-1
position: 26038
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26418:-1
position: 26418
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26038-26418:-1:exon

YML122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML122C
product: uncharacterized protein
transcript id: NM_001348863.1
SIO_010081: YML122C
subclass of: SO_0000673
so part of: YML122C
location: complement(<26038..>26418)
location: region:26038-26418:-1
so has part: feature:26038-26418:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26038-26418:-1:exon

YML122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML122C
note: hypothetical protein; conserved among S. cerevisiae strains; YML122C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MPRNDSNQYYARWCCYRRPIRAAFARKGPFNSSSGYEENVARLKNTRSSHCRTARCQFNSSTWTCYFQHVGRKLATAIDYGSPQSIEISEIGAVMHQMSCERLSLSLFSRFACLLARLKTCVLLIN
SIO_010081: YML122C
subclass of: SO_0000673
so part of: YML122C
location: complement(26038..26418)
location: region:26038-26418:-1
so has part: feature:26038-26418:-1:exon

NP_001335803.1
type: Protein
SIO_000068: ncbiprotein

S000004591
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26038-26418:-1:exon

YML121W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GTR1
locus tag: YML121W
so part of: sequence
location: <26930..>27862
location: region:26930-27862:1
so has part: feature:26930-27862:1:exon
subclass of: SO_0000010

854918
type: Gene
SIO_000068: ncbigene

position:26930:1
position: 26930
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27862:1
position: 27862
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26930-27862:1:exon

YML121W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GTR1
locus tag: YML121W
product: Rag GTPase GTR1
transcript id: NM_001182484.1
SIO_010081: YML121W
subclass of: SO_0000673
so part of: YML121W
location: <26930..>27862
location: region:26930-27862:1
so has part: feature:26930-27862:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26930-27862:1:exon

YML121W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GTR1
locus tag: YML121W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15885099|PMID:19748353|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:22726655|PMID:23716719]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10388807]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10388807]
experiment: EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]
experiment: EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]
experiment: EXISTENCE:direct assay:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]
experiment: EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]
experiment: EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:15937128]
experiment: EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:15937128]
experiment: EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:1620108]
experiment: EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:18258182]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:35158208]
experiment: EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353|PMID:26387955]
experiment: EXISTENCE:physical interaction:GO:0006360 transcription by RNA polymerase I [PMID:15937128]
experiment: EXISTENCE:physical interaction:GO:0006383 transcription by RNA polymerase III [PMID:15937128]
experiment: EXISTENCE:physical interaction:GO:1990131 Gtr1-Gtr2 GTPase complex [PMID:10388807|PMID:16143306]
note: Subunit of TORC1-stimulating GTPase and EGO/GSE complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p; involved in phosphate transport, telomeric chromatin silencing and oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3 pathway; similar to human RagA and RagB
codon start: 1
product: Rag GTPase GTR1
translation: MSSNNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMENYFTKQKDHIFQMVQVLIHVFDVESTEVLKDIEIFAKALKQLRKYSPDAKIFVLLHKMDLVQLDKREELFQIMMKNLSETSSEFGFPNLIGFPTSIWDESLYKAWSQIVCSLIPNMSNHQSNLKKFKEIMNALEIILFERTTFLVICSSNGENSNENHDSSDNNNVLLDPKRFEKISNIMKNFKQSCTKLKSGFKTLILNNNIYVSELSSNMVCFIVLKDMNIPQELVLENIKKAKEFFQ
SIO_010081: YML121W
subclass of: SO_0000673
so part of: YML121W
location: 26930..27862
location: region:26930-27862:1
so has part: feature:26930-27862:1:exon

NP_013585.1
type: Protein
SIO_000068: ncbiprotein

S000004590
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26930-27862:1:exon

YML120C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NDI1
locus tag: YML120C
so part of: sequence
location: complement(<28266..>29807)
location: region:28266-29807:-1
so has part: feature:28266-29807:-1:exon
subclass of: SO_0000010

854919
type: Gene
SIO_000068: ncbigene

position:28266:-1
position: 28266
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:29807:-1
position: 29807
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:28266-29807:-1:exon

YML120C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NDI1
locus tag: YML120C
product: NADH-ubiquinone reductase (H(+)-translocating) NDI1
transcript id: NM_001182483.1
SIO_010081: YML120C
subclass of: SO_0000673
so part of: YML120C
location: complement(<28266..>29807)
location: region:28266-29807:-1
so has part: feature:28266-29807:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:28266-29807:-1:exon

YML120C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NDI1
locus tag: YML120C
EC number: 1.6.5.9
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1900238]
experiment: EXISTENCE:direct assay:GO:0006116 NADH oxidation [PMID:3138118]
experiment: EXISTENCE:direct assay:GO:0006120 mitochondrial electron transport, NADH to ubiquinone [PMID:1900238]
experiment: EXISTENCE:direct assay:GO:0008137 NADH dehydrogenase (ubiquinone) activity [PMID:3138118]
experiment: EXISTENCE:mutant phenotype:GO:0005759 mitochondrial matrix [PMID:1900238]
experiment: EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:16436509]
note: NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy
codon start: 1
product: NADH-ubiquinone reductase (H(+)-translocating) NDI1
translation: MLSKNLYSNKRLLTSTNTLVRFASTRSTGVENSGAGPTSFKTMKVIDPQHSDKPNVLILGSGWGAISFLKHIDTKKYNVSIISPRSYFLFTPLLPSAPVGTVDEKSIIEPIVNFALKKKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVGAEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVVGGGPTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPIVLNMFEKKLSSYAQSHLENTSIKVHLRTAVAKVEEKQLLAKTKHEDGKITEETIPYGTLIWATGNKARPVITDLFKKIPEQNSSKRGLAVNDFLQVKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKNFDKMAQIPNFQKNLSSRKDKIDLLFEENNFKPFKYNDLGALAYLGSERAIATIRSGKRTFYTGGGLMTFYLWRILYLSMILSARSRLKVFFDWIKLAFFKRDFFKGL
SIO_010081: YML120C
subclass of: SO_0000673
so part of: YML120C
location: complement(28266..29807)
location: region:28266-29807:-1
so has part: feature:28266-29807:-1:exon

NP_013586.1
type: Protein
SIO_000068: ncbiprotein

S000004589
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:28266-29807:-1:exon

YML119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML119W
so part of: sequence
location: <30611..>31684
location: region:30611-31684:1
so has part: feature:30611-31684:1:exon
subclass of: SO_0000010

854920
type: Gene
SIO_000068: ncbigene

position:30611:1
position: 30611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31684:1
position: 31684
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:30611-31684:1:exon

YML119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML119W
product: uncharacterized protein
transcript id: NM_001182482.1
SIO_010081: YML119W
subclass of: SO_0000673
so part of: YML119W
location: <30611..>31684
location: region:30611-31684:1
so has part: feature:30611-31684:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:30611-31684:1:exon

YML119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML119W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]
note: hypothetical protein; YML119W is not an essential gene; potential Cdc28p substrate
codon start: 1
product: uncharacterized protein
translation: MSPSPSVSPRRTLNNKSSYINNSGGLVLPPTQFNLNQQPVLSFQQKATFDSNQQFFYYPESPTKNLRPRFNSISQVNKGVNEDHYTGGGSSNNNRPSRYTNTMGAANTNVNSHPHHQSVSHLNSKSLKFNQTKEVSSINEIIFPSRTCTKKRYFTKPIDLYGTRSSTSVAPKLTNSPTKSKTNFNIKKCILPRSVVTTYKLPSPVHETIDDISKKIIILLISLKFEKNYHFLQPIQLSTNSKTRISKSLDELCGVQLTSTLRQQKQLQGNSKPVKNLPNSNAKQRAGASVSTNANESFELSFDGKAMDRSDIFRMVDSFSIAISDEDEEDEEEDSFQQRSANNRILPAEILSNEPLK
SIO_010081: YML119W
subclass of: SO_0000673
so part of: YML119W
location: 30611..31684
location: region:30611-31684:1
so has part: feature:30611-31684:1:exon

NP_013587.1
type: Protein
SIO_000068: ncbiprotein

S000004588
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:30611-31684:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1303; Autonomously Replicating Sequence
so part of: sequence
location: 31766..31835
location: region:31766-31835:1
so has part: feature:31766-31835:1:region

S000118365
type: SGD
SIO_000068: sgd

position:31766:1
position: 31766
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:31835:1
position: 31835
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31766-31835:1:region

YML118W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NGL3
locus tag: YML118W
so part of: sequence
location: <32334..>33851
location: region:32334-33851:1
so has part: feature:32334-33851:1:exon
subclass of: SO_0000010

854921
type: Gene
SIO_000068: ncbigene

position:32334:1
position: 32334
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:33851:1
position: 33851
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:32334-33851:1:exon

YML118W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NGL3
locus tag: YML118W
product: 3'-5' poly(A) RNA exonuclease
transcript id: NM_001182481.1
SIO_010081: YML118W
subclass of: SO_0000673
so part of: YML118W
location: <32334..>33851
location: region:32334-33851:1
so has part: feature:32334-33851:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:32334-33851:1:exon

YML118W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NGL3
locus tag: YML118W
experiment: EXISTENCE:direct assay:GO:0004535 poly(A)-specific ribonuclease activity [PMID:21965533]
experiment: EXISTENCE:direct assay:GO:0043633 polyadenylation-dependent RNA catabolic process [PMID:21965533]
note: 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
codon start: 1
product: 3'-5' poly(A) RNA exonuclease
translation: MDSQVEGKISPSQKESSSTSGLVSPSEDGPAHQKIHRDQLSVDQIKKIREERAQKRQVRRNSLISQGKDPDFPTPDLQFIERPFLPINHDNSKGLTPATIQVTQDSLDVKIMTYNTLAQTLIRRDFFPESGPALKWHKRSKVLVHELKKYRPDVVSLQEVDYNELNFWQENFHKLGFDVIFKRHEGKTHGLLVAWNNKKFQLDNDWMLDYDNILAGNVISARTRTKNIALIISLYFKGITDSSSRGIIVANTHLFWHPFGVFERLRQSYLVLQKIQEIKACSKYNGWHSLLMGDFNTEPEEPPYLAITKRPLILKGPIRAMVECSLAYRYSKKRNGEESDQDDEECDEKSRGEGHSDQPQNPKPESFTATKEEKALVNQLVALHNSLHVKGVSLYGIGYGKVHPENANGSHGEPGLSNWANTWCGLLDYIFYIEGDHNQDTRQKEPLNAFEGNNNVKIIGYLRMPCAQEMPKHSQPFEGEYASDHISLMCQIRLFFGGEKVHSLK
SIO_010081: YML118W
subclass of: SO_0000673
so part of: YML118W
location: 32334..33851
location: region:32334-33851:1
so has part: feature:32334-33851:1:exon

NP_013588.1
type: Protein
SIO_000068: ncbiprotein

S000004587
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:32334-33851:1:exon

YML117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAB6
locus tag: YML117W
so part of: sequence
location: <34243..>37647
location: region:34243-37647:1
so has part: feature:34243-37647:1:exon
subclass of: SO_0000010

854922
type: Gene
SIO_000068: ncbigene

position:34243:1
position: 34243
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:37647:1
position: 37647
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34243-37647:1:exon

YML117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAB6
locus tag: YML117W
product: Nab6p
transcript id: NM_001182479.1
SIO_010081: YML117W
subclass of: SO_0000673
so part of: YML117W
location: <34243..>37647
location: region:34243-37647:1
so has part: feature:34243-37647:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34243-37647:1:exon

YML117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAB6
locus tag: YML117W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]
note: Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
codon start: 1
product: Nab6p
translation: MSNSNSKKPVANYAYRQQQDYNGMNAMVGNPMMYHPVDFVNGAGQYGPSQHPAYYTNSPLPNIPPTPFDTAYGASLFPSHLLMGSPFVSSPNMQSGYNSARSSNLKRKAYSRPVSNHNGYNGNSNSNQNNTNNGMVTPSNYYRMGRNSFSRNNNSTRNVTHNNNKGCDTRNNSGRRTFARNNIFDDILPEMLLQRPFCINYKVLPTGDDAYRTRSLLIENVDHSIDLHSIVKNFVKSNTLESAYLIEGGKSDDSKDVETKNLSILISFLTKGDCLNFYNNILQRLSEFKTFLKSEALNLKFVCLNYDPKCLPTFIESEALTENAEEADITNGSTMISASLHHNIANKDATRSIIIEFKSPVEKSDLFKKKLQFLDRSKNKRYILESIDLVNTDVPSNQFPENYAVLTFLNISMAIEVLDYLKKYSKNLGISKCFYVSLAPLVVSSARSSVANIYEGKTSTHRLSVPSVTAGNNNDSNNNGNNNKSNMSGITTLNNNSSIGVSVYGHSNMSLTSLSSSVSLNEEIDMLATKLQGVELDGTYLEINYRDYQTPTIEEHSTHLSNVKISKTTENSRQFSQDIPSPLPLNEHMFMNDSNQSNGAIIPQQLIATPSPVSPNLQMNQRVLPNPITQSLEQNFNVSAKVASSMGSDIGNRTIYIGNINPRSKAEDICNVVRGGILQSIKYIPEKKICFVTFIEAPSAVQFYANSFIDPIVLHGNMLRVGWGHYSGPLPKLISLAVTIGASRNVYVSLPEFAFKEKFIHDPQYKKLHETLSLPDAEQLREDFSTYGDIEQINYLSDSHCCWINFMNISSAISLVEEMNKESTVQNESGEVTLKRATEEKFGGRYKGLLINYGKDRCGNINKNLIAGKNSRFYKKVKRPSYNIRLSKLEEKRRQNEIDEKEKAFDKPLNLESLGISLDAHKDNGGGETGTANNTGHENESELEAENENGNETGSFGGLGLAVASSDVKRATSDETDYEDIFNKSSGSSDSSSDVEVIMHSPSDPEYALKSQTLRSSSQTVINSKRPVKIEDEEEAVGMSQLNYRSSLRQAPPRAPSTLSYNHSKNNETPMQDIFTNGETANNRKKKRGSFARHRTIPGSDVMAQYLAQVQHSTFMYAANILGASAEDNTHPDE
SIO_010081: YML117W
subclass of: SO_0000673
so part of: YML117W
location: 34243..37647
location: region:34243-37647:1
so has part: feature:34243-37647:1:exon

NP_013589.1
type: Protein
SIO_000068: ncbiprotein

S000004585
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34243-37647:1:exon

YML116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SNQ1
gene: ATR1
locus tag: YML116W
gene synonym: SNQ1
so part of: sequence
location: <38196..>39824
location: region:38196-39824:1
so has part: feature:38196-39824:1:exon
subclass of: SO_0000010

854924
type: Gene
SIO_000068: ncbigene

position:38196:1
position: 38196
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:39824:1
position: 39824
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38196-39824:1:exon

YML116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SNQ1
gene: ATR1
locus tag: YML116W
gene synonym: SNQ1
product: borate transporter
transcript id: NM_001182478.1
SIO_010081: YML116W
subclass of: SO_0000673
so part of: YML116W
location: <38196..>39824
location: region:38196-39824:1
so has part: feature:38196-39824:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:38196-39824:1:exon

YML116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SNQ1
gene: ATR1
locus tag: YML116W
gene synonym: SNQ1
experiment: EXISTENCE:direct assay:GO:0005773 vacuole [PMID:19414602]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19414602]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:2123132]
experiment: EXISTENCE:mutant phenotype:GO:0046713 borate transport [PMID:19414602]
experiment: EXISTENCE:mutant phenotype:GO:0080139 borate efflux transmembrane transporter activity [PMID:19414602]
note: Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: borate transporter
translation: MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQSEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGSEGNSKSWLMASFPLVSGSFILISGRLGDIYGLKKMLLVGYVLVIIWSLICGITKYSGSDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGATLGCLFAGLIGTEDPKQWPWAFYAYSIAAFINFVLSIYAIPSTIPTNIHHFSMDWIGSVLGVIGLILLNFVWNQAPISGWNQAYIIVILIISVIFLVVFIIYEIRFAKTPLLPRAVIKDRHMIQIMLALFFGWGSFGIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGIIAALLVGFTIKNVSPSVFLFFSMVAFNVGSIMASVTPVHETYFRTQLGTMIILSFGMDLSFPASSIIFSDNLPMEYQGMAGSLVNTVVNYSMSLCLGMGATVETQVNSDGKHLLKGYRGAQYLGIGLASLACMISGLYMVESFIKGRRARAAAEYDCTVA
SIO_010081: YML116W
subclass of: SO_0000673
so part of: YML116W
location: 38196..39824
location: region:38196-39824:1
so has part: feature:38196-39824:1:exon

NP_013591.1
type: Protein
SIO_000068: ncbiprotein

S000004584
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38196-39824:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1304; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 39824..40187
location: region:39824-40187:1
so has part: feature:39824-40187:1:region

S000130187
type: SGD
SIO_000068: sgd

position:40187:1
position: 40187
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:39824-40187:1:region

YML115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LDB13
alternative label: VRG7
alternative label: VRG8
gene: VAN1
locus tag: YML115C
gene synonym: LDB13; VRG7; VRG8
so part of: sequence
location: complement(<40187..>41794)
location: region:40187-41794:-1
so has part: feature:40187-41794:-1:exon
subclass of: SO_0000010

854925
type: Gene
SIO_000068: ncbigene

position:40187:-1
position: 40187
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:41794:-1
position: 41794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40187-41794:-1:exon

YML115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LDB13
alternative label: VRG7
alternative label: VRG8
gene: VAN1
locus tag: YML115C
gene synonym: LDB13; VRG7; VRG8
product: Van1p
transcript id: NM_001182477.1
SIO_010081: YML115C
subclass of: SO_0000673
so part of: YML115C
location: complement(<40187..>41794)
location: region:40187-41794:-1
so has part: feature:40187-41794:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40187-41794:-1:exon

YML115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LDB13
alternative label: VRG7
alternative label: VRG8
gene: VAN1
locus tag: YML115C
gene synonym: LDB13; VRG7; VRG8
experiment: EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:12235155]
experiment: EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]
experiment: EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9430634]
experiment: EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:12235155]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9430634]
note: Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
codon start: 1
product: Van1p
translation: MGMFFNLRSNIKKKAMDNGLSLPISRNGSSNNIKDKRSEHNSNSLKGKYRYQPRSTPSKFQLTVSITSLIIIAVLSLYLFISFLSGMGIGVSTQNGRSLLGSSKSSENYKTIDLEDEEYYDYDFEDIDPEVISKFDDGVQHYLISQFGSEVLTPKDDEKYQRELNMLFDSTVEEYDLSNFEGAPNGLETRDHILLCIPLRNAADVLPLMFKHLMNLTYPHELIDLAFLVSDCSEGDTTLDALIAYSRHLQNGTLSQIFQEIDAVIDSQTKGTDKLYLKYMDEGYINRVHQAFSPPFHENYDKPFRSVQIFQKDFGQVIGQGFSDRHAVKVQGIRRKLMGRARNWLTANALKPYHSWVYWRDADVELCPGSVIQDLMSKNYDVIVPNVWRPLPTFLGTEQPYDLNSWMESQEALALAKTLDEDDVIVEGYAEYPTWRVHLAYIRDAEGDPNEAVDLDGVGGVSILAKAKIFRNGVQFPAFTFENHAETEAFGKMAKKMGYRVGGLPHYTIWHIYEPSDDDLKEIASREREKRRQSE
SIO_010081: YML115C
subclass of: SO_0000673
so part of: YML115C
location: complement(40187..41794)
location: region:40187-41794:-1
so has part: feature:40187-41794:-1:exon

NP_013592.1
type: Protein
SIO_000068: ncbiprotein

S000004583
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40187-41794:-1:exon

YML114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAF65
gene: TAF8
locus tag: YML114C
gene synonym: TAF65
so part of: sequence
location: complement(<42043..>43575)
location: region:42043-43575:-1
so has part: feature:42043-43575:-1:exon
subclass of: SO_0000010

854926
type: Gene
SIO_000068: ncbigene

position:42043:-1
position: 42043
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:43575:-1
position: 43575
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42043-43575:-1:exon

YML114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAF65
gene: TAF8
locus tag: YML114C
gene synonym: TAF65
product: Taf8p
transcript id: NM_001182476.1
SIO_010081: YML114C
subclass of: SO_0000673
so part of: YML114C
location: complement(<42043..>43575)
location: region:42043-43575:-1
so has part: feature:42043-43575:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42043-43575:-1:exon

YML114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAF65
gene: TAF8
locus tag: YML114C
gene synonym: TAF65
experiment: EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:15448131]
experiment: EXISTENCE:curator inference:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10788514]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]
note: TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation
codon start: 1
product: Taf8p
translation: MTSKTSESGTGTQSTIVQLRNLPDLTEISHLEIDAPVVEILKKTVLFQLNSLNICISNFALDELVNLVTVQMDGMFRNLHNLTLLQRRSQASQADLKLLLREFNLDAPSLYQQFQASEFIKSKHSTEYEKLMSWSSLAALPHNEEDEEDELNNIEEQQNEINVLLPPSNPLEKQIPSWLPNFPPDHTYKFTPEFNHPITDLKTIKKEIVKESQESEKALLNLNKSLSHISSASNTPQPPGLDDEDAIEQQLEIWGNALEERKPTITEKSFNENNIEQYAKYRVELARERVTKFEVNQLKRTKNPFLKISETLYLPESPHQSHKTIQKTIELQFRKSMTLFMHNLPKVQKLKKEKIRMAKEERAKSLKRRQEELISQRTKREQDEGHDLELLLNNEHARDAADDTTTPNALNNSTIVINTNAEDEDDDINLFGILGSSEDENEMSSMPAENLVAESEPPTMTAQDTTNTTPVAHNTTNIDATTSHSPHSTPNENAPTSPPADIATDHDITM
SIO_010081: YML114C
subclass of: SO_0000673
so part of: YML114C
location: complement(42043..43575)
location: region:42043-43575:-1
so has part: feature:42043-43575:-1:exon

NP_013593.1
type: Protein
SIO_000068: ncbiprotein

S000004582
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42043-43575:-1:exon

YML113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DAT1
locus tag: YML113W
so part of: sequence
location: <44045..>44791
location: region:44045-44791:1
so has part: feature:44045-44791:1:exon
subclass of: SO_0000010

854927
type: Gene
SIO_000068: ncbigene

position:44045:1
position: 44045
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:44791:1
position: 44791
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:44045-44791:1:exon

YML113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DAT1
locus tag: YML113W
product: Dat1p
transcript id: NM_001182475.1
SIO_010081: YML113W
subclass of: SO_0000673
so part of: YML113W
location: <44045..>44791
location: region:44045-44791:1
so has part: feature:44045-44791:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:44045-44791:1:exon

YML113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DAT1
locus tag: YML113W
experiment: EXISTENCE:direct assay:GO:0003680 minor groove of adenine-thymine-rich DNA binding [PMID:2670564]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8248247]
note: DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability
codon start: 1
product: Dat1p
translation: MAKTLAQGRKPGSGRKPGKGKTLREGRKPGSGRRRRQDTGGKETDGSQQDQESRLISSRDMEAVDALRELTHSPSSHSAHNSSAAPPPHAAAASTSLPPSLDYTHQSFMDQQQQQQQQQQQQLLQQQRVDVVPPKPFITHKILLSSTGNSGGHVNSNYNADHSINHNSNHNLNSNVNVNMNFTINGSNQDPSSSFLMGPYNYLQRPFIVKPYLDLSTSTAASNQPRTQPSPAAHITKNSDSTEKNATI
SIO_010081: YML113W
subclass of: SO_0000673
so part of: YML113W
location: 44045..44791
location: region:44045-44791:1
so has part: feature:44045-44791:1:exon

NP_013594.1
type: Protein
SIO_000068: ncbiprotein

S000004581
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:44045-44791:1:exon

YML112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTK3
locus tag: YML112W
so part of: sequence
location: <45063..>45953
location: region:45063-45953:1
so has part: feature:45063-45953:1:exon
subclass of: SO_0000010

854928
type: Gene
SIO_000068: ncbigene

position:45063:1
position: 45063
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45953:1
position: 45953
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45063-45953:1:exon

YML112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTK3
locus tag: YML112W
product: Ctk3p
transcript id: NM_001182474.1
SIO_010081: YML112W
subclass of: SO_0000673
so part of: YML112W
location: <45063..>45953
location: region:45063-45953:1
so has part: feature:45063-45953:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45063-45953:1:exon

YML112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTK3
locus tag: YML112W
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:11118453]
experiment: EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]
experiment: EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]
experiment: EXISTENCE:direct assay:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:11118453]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]
experiment: EXISTENCE:physical interaction:GO:0045903 positive regulation of translational fidelity [PMID:17545469]
note: Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
codon start: 1
product: Ctk3p
translation: MDSLEARLQFIQVLKNLQKTLHKTRDSITSSSTTTPPSSQQKLNNDPIQFYLRNYRHHYEDFHQCLFDTTMKMDPLDRLDVVIYYVRIIRNLYPHSHSNTNVTKVLNEVLLMDIDLVFELCLPCQDWKSLTNQATCKELFLDLSKLIHYDATSVTHTPSDTTLIDATTWYSVKTERTTKDYKESLQRTESLLKDRDLKKLAFFQQFNSDTTAINPDLQTQPTNANILLHRMEADRELHKRSKETSWYIERPSNDILDESEFKSLWTHFETTDSGFDKDDYKNIKALNDIAKASYIY
SIO_010081: YML112W
subclass of: SO_0000673
so part of: YML112W
location: 45063..45953
location: region:45063-45953:1
so has part: feature:45063-45953:1:exon

NP_013595.1
type: Protein
SIO_000068: ncbiprotein

S000004580
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45063-45953:1:exon

YML111W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUL2
locus tag: YML111W
so part of: sequence
location: <46942..>49704
location: region:46942-49704:1
so has part: feature:46942-49704:1:exon
subclass of: SO_0000010

854929
type: Gene
SIO_000068: ncbigene

position:46942:1
position: 46942
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:49704:1
position: 49704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:46942-49704:1:exon

YML111W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUL2
locus tag: YML111W
product: ubiquitin-ubiquitin ligase BUL2
transcript id: NM_001182473.1
SIO_010081: YML111W
subclass of: SO_0000673
so part of: YML111W
location: <46942..>49704
location: region:46942-49704:1
so has part: feature:46942-49704:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:46942-49704:1:exon

YML111W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUL2
locus tag: YML111W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:11352928]
experiment: EXISTENCE:mutant phenotype:GO:0000151 ubiquitin ligase complex [PMID:11352928]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:9931424]
experiment: EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:9931424]
note: Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-ubiquitin ligase BUL2
translation: MTFTFSTSSRKNGRPPLKSVSTEDNIHLLRKRRQQQLSSNSTDNSLHPNSGQTPRASDSQDDDIRSASTTNLDRLRQEREENSLEMDCTQSRLSHRANMLVDVLPSFEMYNALHRHIPQGNVDPDRHDFPPSYQEVRTQRMTILPSNDNSVERSQLTAVPGSENACNNATAHSLTNLHPLQTQHLTINSTRSGGQSLHSSSDTNISQIPFEDDLNDSDNIFIDKLYTLPKLSTPIEIDIRITKTASIPHERPEEQSILKEYTSGDIIHGYCLIENRSSQPLKFEMFYVTLEAYISVIDRQKGKRTLKRFLRMVDLSASWSYTNITPSTGINIVPGERDFDDAIIGLSNSRELKPNTKYKKFFMFKLPTQLLDVTCKQEQFSHCLLPPSFGIDKYKNNCKYSGIKVNSVLGCGHLGTKGSPILTLDMADDNLSINYTIDAKIVGKDKRTSKLNIMKEKEYNLRVMPFPFAGVTNQQNEKTCLRQLKNLESLIEDRFEALNKIFKKLELNEAISNVDIHDTDISGTLDGNEDLDSDEILRRKLDQLHINNRIDDTASQSPSYDSKNMAPKENLVETELRYKFKNKNKSNSSLFSHFLSSSETGSSSTGPHVYNSGLIVLSVKKPQSTLPYWSPSLLRKTNKFEAKSEQEKENWQRLMGMLPEGVKTPLTKLDVHLTCIQSNNSAGHKPPEISSVTTEFVVITAKSDNSIPIKFCTELLMNENRLNKLKTKFLTYQKKVHEYRKKFEENHAKLNELYNRNRDHFTPKELLFTNFISDQINNDIDSLAGLKVNIIDLHDIFKKQIHTFEEENEDIISKKGSSNPPSASSSNNNFLQATFSNGASTATKFTQQIVHEWEKVKPLQYKRDVTVNLKLNPNIKETLVPNLETCLCCRFYCVRVNIKFDNHLGSMKVDIPVDVKKLQI
SIO_010081: YML111W
subclass of: SO_0000673
so part of: YML111W
location: 46942..49704
location: region:46942-49704:1
so has part: feature:46942-49704:1:exon

NP_013596.1
type: Protein
SIO_000068: ncbiprotein

S000004579
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:46942-49704:1:exon

YML110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DBI56
gene: COQ5
locus tag: YML110C
gene synonym: DBI56
so part of: sequence
location: complement(<50031..>50954)
location: region:50031-50954:-1
so has part: feature:50031-50954:-1:exon
subclass of: SO_0000010

854930
type: Gene
SIO_000068: ncbigene

position:50031:-1
position: 50031
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:50954:-1
position: 50954
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:50031-50954:-1:exon

YML110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DBI56
gene: COQ5
locus tag: YML110C
gene synonym: DBI56
product: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
transcript id: NM_001182472.1
SIO_010081: YML110C
subclass of: SO_0000673
so part of: YML110C
location: complement(<50031..>50954)
location: region:50031-50954:-1
so has part: feature:50031-50954:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:50031-50954:-1:exon

YML110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DBI56
gene: COQ5
locus tag: YML110C
gene synonym: DBI56
EC number: 2.1.1.201
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9083048]
experiment: EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9083048]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9083049]
experiment: EXISTENCE:mutant phenotype:GO:0043334 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [PMID:9083049]
note: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5
codon start: 1
product: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase
translation: MLISSRIVRSSLVNVPLRLSRCFTQAHRACKEEEVNSPLSSAAEQPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESKFGDTESTMDIVDINPDMLKEGEKRAMEQGKYFKDPRVRFLVSNGEKLEEIDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYESLTFGICAIHWGIKV
SIO_010081: YML110C
subclass of: SO_0000673
so part of: YML110C
location: complement(50031..50954)
location: region:50031-50954:-1
so has part: feature:50031-50954:-1:exon

NP_013597.1
type: Protein
SIO_000068: ncbiprotein

S000004578
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:50031-50954:-1:exon

YML109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CES4
gene: ZDS2
locus tag: YML109W
gene synonym: CES4
so part of: sequence
location: <51640..>54468
location: region:51640-54468:1
so has part: feature:51640-54468:1:exon
subclass of: SO_0000010

854931
type: Gene
SIO_000068: ncbigene

position:51640:1
position: 51640
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:54468:1
position: 54468
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:51640-54468:1:exon

YML109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CES4
gene: ZDS2
locus tag: YML109W
gene synonym: CES4
product: Zds2p
transcript id: NM_001182471.1
SIO_010081: YML109W
subclass of: SO_0000673
so part of: YML109W
location: <51640..>54468
location: region:51640-54468:1
so has part: feature:51640-54468:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:51640-54468:1:exon

YML109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CES4
gene: ZDS2
locus tag: YML109W
gene synonym: CES4
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21536748]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20980617]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21536748]
experiment: EXISTENCE:genetic interaction:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:20980617]
experiment: EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:8816439]
experiment: EXISTENCE:genetic interaction:GO:0032880 regulation of protein localization [PMID:18762578]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10662670]
experiment: EXISTENCE:mutant phenotype:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:21536748]
note: Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
codon start: 1
product: Zds2p
translation: MVLMEDMQNKDGHNTVENSSGGTDSNNNIQMRRMRKTQLSKKELFEKRKSDVLIAAKSLDTEIQNVKNLKRLSIGSMDLVIDPELEFKVNSRNSYSSDSSKESLQESLHEENIIRSEQKEEQGSEDNDAYEEGDATNVDDSIDITQTEYLHDEETLEKEKIIRNASSSTSSSARVTSRNRRLSGVKTLAHDVVLDVENDHDSKMVDLTQNLLWVPADQHPNVKPENYLELIQDTLQNIQISTNQDIDENKLELGNNHVISNRKRTGSVVRRPSRLKTSYTKFDDEPPLADKPQEGEIQVDKRISSSDIKTIRSVSLKEITEELTKISNNAGLTDSDAVTLARSLSMSGSFTNESLHLNGNHTENDNEFASNMFNETGLTIPERSSLRRSKFNTYKIRLEGSSLPQAVKLNSLMNIQTNDNRRSASSPASYTQVPQEQASLNDFHEIFDHYRRTSTDWSTENEKYVDSTNYYSDEEDLTHASISQESSLLSTDSSNNSVLIKPHNTGSMISEKLDQHVSSSEKSNTNNSEANHGWSWLNSSNGSLNANEQTYQQLTDDEDDEECVDNEKADFVNLSVSRRAKSTKRASERINHSKNRHSPIFQIHSEEAKSVVITPSVVSSSESQPSKPTAPAVVEKKVELPTDTQASTHKKNSLEKRLAKLFKRKQHNGTCKSDVKVIKKSVKKELKKKASHSSLSKFRKSPKKKPQEAEVERPSSPTKTITTEDIDTASVIEPEVRSSNASTLLPDSHTSHSSEFVVETISELDGDDSFDISGGDVNYDVEVHSSISRDTTAGLEEDIGAEREDNTSPTAPQISTLPPRKLTFEDVVKPDYSNAPIKFTDSAFGFPLPMITNSTVIMFDHRLGINVERAIYRLSHLKLSDPGRELRQQVLLSNFMYSYLNLVNHTLYMEQVGTGDIAFNGDSALGMMDKNDSDGTILIPDI
SIO_010081: YML109W
subclass of: SO_0000673
so part of: YML109W
location: 51640..54468
location: region:51640-54468:1
so has part: feature:51640-54468:1:exon

NP_013598.1
type: Protein
SIO_000068: ncbiprotein

S000004577
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:51640-54468:1:exon

YML108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML108W
so part of: sequence
location: <54793..>55110
location: region:54793-55110:1
so has part: feature:54793-55110:1:exon
subclass of: SO_0000010

854863
type: Gene
SIO_000068: ncbigene

position:54793:1
position: 54793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55110:1
position: 55110
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54793-55110:1:exon

YML108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML108W
product: uncharacterized protein
transcript id: NM_001182470.1
SIO_010081: YML108W
subclass of: SO_0000673
so part of: YML108W
location: <54793..>55110
location: region:54793-55110:1
so has part: feature:54793-55110:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54793-55110:1:exon

YML108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML108W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
note: hypothetical protein; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MSKSNTYRMLVLLEDDTKINKEDEKFLKGKPGKMHEFVDELILPFNVDELDELNTWFDKFDAEICIPNEGHIKYEISSDGLIVLMLDKEIEEVVEKVKKFVEENN
SIO_010081: YML108W
subclass of: SO_0000673
so part of: YML108W
location: 54793..55110
location: region:54793-55110:1
so has part: feature:54793-55110:1:exon

NP_013599.1
type: Protein
SIO_000068: ncbiprotein

S000004576
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54793-55110:1:exon

YML107C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PML39
locus tag: YML107C
so part of: sequence
location: complement(<55265..>56269)
location: region:55265-56269:-1
so has part: feature:55265-56269:-1:exon
subclass of: SO_0000010

854864
type: Gene
SIO_000068: ncbigene

position:55265:-1
position: 55265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:56269:-1
position: 56269
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:55265-56269:-1:exon

YML107C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PML39
locus tag: YML107C
product: Pml39p
transcript id: NM_001182469.1
SIO_010081: YML107C
subclass of: SO_0000673
so part of: YML107C
location: complement(<55265..>56269)
location: region:55265-56269:-1
so has part: feature:55265-56269:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:55265-56269:-1:exon

YML107C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PML39
locus tag: YML107C
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:16162818]
experiment: EXISTENCE:mutant phenotype:GO:0051237 maintenance of RNA location [PMID:16162818]
note: Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
codon start: 1
product: Pml39p
translation: MEKDALEVRLKSIRHSLDKNTKLLPGKYRNTLGERLITKWRYKKKSHNGSSMLPEKCKSHVQLYDDLVQESSKHFVGFRLHDLRALLKRICSIQNYTRHVLIEWDVRWVNPLTLASKGWEPYQSASQSQVPFKCCCCHAIMTIPLLKNGDDVADYTMKLNEKIWNSNIIGNHLQKCPWRENQVDLNKEYYLSSQNLIREIERIHTEIDRIVSGSNEFSLKRNSSRIFHYLSEKEIQKLAFFFDCKDYSLVGLLLLGYTKFQKDDLVQCTACFHRASLKKLEYTEFNGHALWCRYYNKELLPTMLLELIGKEDKLITKLGVGERLNKLEAVLQTL
SIO_010081: YML107C
subclass of: SO_0000673
so part of: YML107C
location: complement(55265..56269)
location: region:55265-56269:-1
so has part: feature:55265-56269:-1:exon

NP_013600.2
type: Protein
SIO_000068: ncbiprotein

S000004575
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:55265-56269:-1:exon

YML106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PYR5
gene: URA5
locus tag: YML106W
gene synonym: PYR5
so part of: sequence
location: <56773..>57453
location: region:56773-57453:1
so has part: feature:56773-57453:1:exon
subclass of: SO_0000010

854865
type: Gene
SIO_000068: ncbigene

position:56773:1
position: 56773
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:57453:1
position: 57453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56773-57453:1:exon

YML106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PYR5
gene: URA5
locus tag: YML106W
gene synonym: PYR5
product: orotate phosphoribosyltransferase URA5
transcript id: NM_001182468.1
SIO_010081: YML106W
subclass of: SO_0000673
so part of: YML106W
location: <56773..>57453
location: region:56773-57453:1
so has part: feature:56773-57453:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56773-57453:1:exon

YML106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PYR5
gene: URA5
locus tag: YML106W
gene synonym: PYR5
EC number: 2.4.2.10
experiment: EXISTENCE:direct assay:GO:0004588 orotate phosphoribosyltransferase activity [PMID:9882434]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:9882434]
experiment: EXISTENCE:mutant phenotype:GO:0004588 orotate phosphoribosyltransferase activity [PMID:4550660]
experiment: EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660]
experiment: EXISTENCE:mutant phenotype:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:4550660]
note: Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
codon start: 1
product: orotate phosphoribosyltransferase URA5
translation: MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLATAYAIAIIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQYLQTYGASA
SIO_010081: YML106W
subclass of: SO_0000673
so part of: YML106W
location: 56773..57453
location: region:56773-57453:1
so has part: feature:56773-57453:1:exon

NP_013601.1
type: Protein
SIO_000068: ncbiprotein

S000004574
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56773-57453:1:exon

YML105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC65
locus tag: YML105C
so part of: sequence
location: complement(<57866..>58687)
location: region:57866-58687:-1
so has part: feature:57866-58687:-1:exon
subclass of: SO_0000010

854866
type: Gene
SIO_000068: ncbigene

position:57866:-1
position: 57866
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58687:-1
position: 58687
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:57866-58687:-1:exon

YML105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC65
locus tag: YML105C
product: RNA-binding signal recognition particle subunit SEC65
transcript id: NM_001182467.1
SIO_010081: YML105C
subclass of: SO_0000673
so part of: YML105C
location: complement(<57866..>58687)
location: region:57866-58687:-1
so has part: feature:57866-58687:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:57866-58687:-1:exon

YML105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC65
locus tag: YML105C
experiment: EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:1313947|PMID:7925282]
experiment: EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]
experiment: EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:14681587]
experiment: EXISTENCE:mutant phenotype:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:1313948]
experiment: EXISTENCE:mutant phenotype:GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [PMID:1313947]
note: Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
codon start: 1
product: RNA-binding signal recognition particle subunit SEC65
translation: MPRLEEIDDFNDIDDLDMELAELDPSLRTPIAPKITPKVVRSQDQENPAFLPGTNNNSNSNNNSSNEKEQLSFINPKTGKVERSEAISKKDLEEVKRFQVLYPCYFDINRSHKEGRRVPKELAVENPLAKTMADAVRELGILCIFEGEKCHPQDFGNPGRIRVLFKENGQLIGAATKFKGGKRQLMKAVGEYMKRHPTTIESLREIPYGPDFDNIEFKKIPRVKGFKMNEIVPLHSPFLMGHPMTKSVYETPKITAAEKSFKPPKNKYKVVRR
SIO_010081: YML105C
subclass of: SO_0000673
so part of: YML105C
location: complement(57866..58687)
location: region:57866-58687:-1
so has part: feature:57866-58687:-1:exon

NP_013602.1
type: Protein
SIO_000068: ncbiprotein

S000004573
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:57866-58687:-1:exon

YML104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDM1
locus tag: YML104C
so part of: sequence
location: complement(<58939..>62322)
location: region:58939-62322:-1
so has part: feature:58939-62322:-1:exon
subclass of: SO_0000010

854867
type: Gene
SIO_000068: ncbigene

position:58939:-1
position: 58939
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:62322:-1
position: 62322
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58939-62322:-1:exon

YML104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDM1
locus tag: YML104C
product: Mdm1p
transcript id: NM_001182466.1
SIO_010081: YML104C
subclass of: SO_0000673
so part of: YML104C
location: complement(<58939..>62322)
location: region:58939-62322:-1
so has part: feature:58939-62322:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:58939-62322:-1:exon

YML104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDM1
locus tag: YML104C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26283797]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:2202739|PMID:9245780]
experiment: EXISTENCE:mutant phenotype:GO:1990854 vacuole-ER tethering [PMID:26283797]
note: PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease
codon start: 1
product: Mdm1p
translation: MPKFPQFRLILVLFYLISMIQWSVITFSLGFFLNVCIFAYFVFFKSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKELESIVNLIIKDFVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRFLPLFKKTPSFLKMLSTSHIISTDIYAHFLSRIGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDNTSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASLTISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFRKTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFKLNKEYMHDDILEEPLHEPIGSSNSTSNSSSVVDLQSSEDGGELNFYEDERHFFTDSGYPFYSQNKSFVKQICDLFISLFALNKANAGWLRGRAIITVLQQLLGSTIEKYIKVSIQKLRSEDQVFEAIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLALTSLQRLFADTCGRVVGLRDSHEAAGRVHAMLQNPYLNASLLLEALDAILLDIICND
SIO_010081: YML104C
subclass of: SO_0000673
so part of: YML104C
location: complement(58939..62322)
location: region:58939-62322:-1
so has part: feature:58939-62322:-1:exon

NP_013603.1
type: Protein
SIO_000068: ncbiprotein

S000004572
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:58939-62322:-1:exon

YML103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUP188
locus tag: YML103C
so part of: sequence
location: complement(<62582..>67549)
location: region:62582-67549:-1
so has part: feature:62582-67549:-1:exon
subclass of: SO_0000010

854868
type: Gene
SIO_000068: ncbigene

position:62582:-1
position: 62582
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:67549:-1
position: 67549
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62582-67549:-1:exon

YML103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUP188
locus tag: YML103C
product: Nup188p
transcript id: NM_001182465.1
SIO_010081: YML103C
subclass of: SO_0000673
so part of: YML103C
location: complement(<62582..>67549)
location: region:62582-67549:-1
so has part: feature:62582-67549:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:62582-67549:-1:exon

YML103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUP188
locus tag: YML103C
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:16361228]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:8682855]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16361228|PMID:8682855]
experiment: EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:8682855]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
note: Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
codon start: 1
product: Nup188p
translation: MATPSFGNSSPQLTFTHVANFMNDAAADVSAVDAKQLAQIRQFLKANKTNLIESLNTIRQNVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAVEFFMSERSSRLHIVYSLLVNPDIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSLAHDYNNDQDMFTIVSLVQLKKFSDLKFILQILQILNLMILNTKVPVDIVNQWFLQYQNQFVEFCRNINSTDKSIDTSSLQLYKFQNFQDLSYLSETLISRISSLFTITTILILGLNTSIAQFDIQSPLYMDTETFDTVNSALENDVATNIVNEDPIFHPMIHYSWSFILYYRRALQSSESFDDSDITKFALFAESHDVLQKLNTLSEILSFDPVYTTVITVFLEFSLNFIPITASTSRVFAKIISKAPEQFIENFLTNDTFEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICSFAVTKSSLNDLDYDLIADTITNSSSSSDIIVPDLIELKSDLLVAPPLENENSNCLLSIPKSTKGKILTIKQQQQQQQQQNGQQPPTTSNLIIFLYKFNGWSLVGRILQNLLHSYMEKGTQLDDLQHELMISIIKLVTNVVDPKTSIEKSSEILSYLSNSLDTSASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEFMTMLTPNYLHLVSSYLNKSDLLDKYGKTGLSNMILGSVELSTGDYTFTIQLLKLTKVFIRESLSLKNIHISKRSKIDIINKLILHAIHIFESYYNWKYNNFLQKFEIAFHLTLIFYDVLHDVFTINPHQKDQLIISSSANKLLQLFLTPMDSIDLAPNTLTNILISPLNTTTKILGDKILGNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLEKLLFINSSKLVDVYTLPSYVHFKVQIIELLSYLVEAPWNDDYPFLLSFLGEAKSMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLLESKQDGLSILFLTGQFASNKKINDESSIDKKSSILTVLQKNSLLLDSTPEEVSCKLLETITYVLNTWTNSKIFIKDPKFVNSLLAKLKDSKKLFQKKENLTRDETVSLIKKYKLISRIVEIFALCIYNSTDSNSEILNFLNQEDLFELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQSFQKIPLSRINENENFGYDIPLLDIVLKADRSWNEPSKSQTNFKEEITDASLNLQYVNYEISTAKAWGALITTFVKRSTVPLNDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFYILYSFKLSGKLLKEEKIIELMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLELVSSGDRFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHTTQIVNLEDNTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLYSSAHLIRINDEPILGQITLTFISELCSIEPIAAKLINSGLYSVLLESPLSVAIQQGDIKPEFSPRLHNIWSNGLLSIVLLLLSQFGIKVLPETCLFVSYFGKQIKSTIYNWGDNKLAVSSSLIKETNQLVLLQKMLNLLNYQELFIQPKNSDDQQEAVELVIGLDSEHDKKRLSAALSKFLTHPKYLNSRIIPTTLEEQQQLEDESSRLEFVKGISRDIKALQDSLFKDV
SIO_010081: YML103C
subclass of: SO_0000673
so part of: YML103C
location: complement(62582..67549)
location: region:62582-67549:-1
so has part: feature:62582-67549:-1:exon

NP_013604.1
type: Protein
SIO_000068: ncbiprotein

S000004571
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62582-67549:-1:exon

YNCM0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR85
locus tag: YNCM0002C
so part of: sequence
location: complement(67768..67938)
location: region:67768-67938:-1
so has part: feature:67768-67938:-1:exon
subclass of: SO_0000578

9164957
type: Gene
SIO_000068: ncbigene

position:67768:-1
position: 67768
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:67938:-1
position: 67938
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67768-67938:-1:exon

YNCM0002C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR85
locus tag: YNCM0002C
product: SNR85
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:15923376]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15923376]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:15923376]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); predicted to guide pseudouridylation of small subunit (SSU) rRNA at position U1181
transcript id: NR_132234.1
SIO_010081: YNCM0002C
subclass of: SO_0000673
so part of: YNCM0002C
location: complement(67768..67938)
location: region:67768-67938:-1
so has part: feature:67768-67938:-1:exon

S000081376
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67768-67938:-1:exon

YML102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAC2
locus tag: YML102W
so part of: sequence
location: <68294..>69700
location: region:68294-69700:1
so has part: feature:68294-69700:1:exon
subclass of: SO_0000010

854869
type: Gene
SIO_000068: ncbigene

position:68294:1
position: 68294
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:69700:1
position: 69700
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:68294-69700:1:exon

YML102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAC2
locus tag: YML102W
product: Cac2p
transcript id: NM_001182464.1
SIO_010081: YML102W
subclass of: SO_0000673
so part of: YML102W
location: <68294..>69700
location: region:68294-69700:1
so has part: feature:68294-69700:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:68294-69700:1:exon

YML102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAC2
locus tag: YML102W
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:11782447]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]
experiment: EXISTENCE:direct assay:GO:0033186 CAF-1 complex [PMID:9030687]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16503640]
experiment: EXISTENCE:mutant phenotype:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]
note: Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Cac2p
translation: MEASHLQIYWHDSQPVYSLTFQKNSANDKLFTAGGDNKVRIWKLNRDENGQNGGVRKIESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQESVVRPFGMDAETSEADENKEKWVVWKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVILSSAGVVTGLKLRSKIAKAELPCPGDVLRTNYLFHNETLPSFFRRCSISPCGGLVVIPSGVYKVAGDEVANCVYVYTRSGILNSAGGVKNRPAIRIPSLKKPALMAAFSPVFYETCQKSVLKLPYKLVFAIATTNEVLVYDTDVLEPLCVVGNIHYSPITDLAWSEDGSTLLISSTDGFCSYVSIDTETQFGSRIEPPAMHAEPLDTDESAVAAKNQREAGGIVNMLPVKKIPCNSSDSKKRRIHPTPVDL
SIO_010081: YML102W
subclass of: SO_0000673
so part of: YML102W
location: 68294..69700
location: region:68294-69700:1
so has part: feature:68294-69700:1:exon

NP_013605.1
type: Protein
SIO_000068: ncbiprotein

S000004570
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:68294-69700:1:exon

YML101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUE4
locus tag: YML101C
so part of: sequence
location: complement(<69735..>70088)
location: region:69735-70088:-1
so has part: feature:69735-70088:-1:exon
subclass of: SO_0000010

854871
type: Gene
SIO_000068: ncbigene

position:69735:-1
position: 69735
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70088:-1
position: 70088
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:69735-70088:-1:exon

YML101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUE4
locus tag: YML101C
product: Cue4p
transcript id: NM_001182462.1
SIO_010081: YML101C
subclass of: SO_0000673
so part of: YML101C
location: complement(<69735..>70088)
location: region:69735-70088:-1
so has part: feature:69735-70088:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:69735-70088:-1:exon

YML101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUE4
locus tag: YML101C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
note: hypothetical protein; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
codon start: 1
product: Cue4p
translation: MDGSTIVFILTMVCLFVYTVKHRGAKQVPSRTVQDAKPAPSVATNDPSPEPVPSAPEERVARLNRHGSDRKRAVNSDMVEIVMTMAPHVPQEKVVQDLRNTGSIEHTMENIFAGKLD
SIO_010081: YML101C
subclass of: SO_0000673
so part of: YML101C
location: complement(69735..70088)
location: region:69735-70088:-1
so has part: feature:69735-70088:-1:exon

NP_013607.1
type: Protein
SIO_000068: ncbiprotein

S000004568
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:69735-70088:-1:exon

YML100W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML100W-A
so part of: sequence
location: <70138..>70311
location: region:70138-70311:1
so has part: feature:70138-70311:1:exon
subclass of: SO_0000010

1466496
type: Gene
SIO_000068: ncbigene

position:70138:1
position: 70138
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70311:1
position: 70311
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70138-70311:1:exon

YML100W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML100W-A
product: uncharacterized protein
transcript id: NM_001184612.1
SIO_010081: YML100W-A
subclass of: SO_0000673
so part of: YML100W-A
location: <70138..>70311
location: region:70138-70311:1
so has part: feature:70138-70311:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70138-70311:1:exon

YML100W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML100W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MYKCVPSYYSKAGTIVVTYCEISALLVSLKNRVQGKRGETEGQIEISRKAGHPAPAF
SIO_010081: YML100W-A
subclass of: SO_0000673
so part of: YML100W-A
location: 70138..70311
location: region:70138-70311:1
so has part: feature:70138-70311:1:exon

NP_878138.1
type: Protein
SIO_000068: ncbiprotein

S000028688
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70138-70311:1:exon

YML100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TSL1
locus tag: YML100W
so part of: sequence
location: <70624..>73920
location: region:70624-73920:1
so has part: feature:70624-73920:1:exon
subclass of: SO_0000010

854872
type: Gene
SIO_000068: ncbigene

position:70624:1
position: 70624
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73920:1
position: 73920
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70624-73920:1:exon

YML100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TSL1
locus tag: YML100W
product: trehalose 6-phosphate synthase/phosphatase complex subunit
transcript id: NM_001182460.1
SIO_010081: YML100W
subclass of: SO_0000673
so part of: YML100W
location: <70624..>73920
location: region:70624-73920:1
so has part: feature:70624-73920:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70624-73920:1:exon

YML100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TSL1
locus tag: YML100W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:8404905]
experiment: EXISTENCE:genetic interaction:GO:0004805 trehalose-phosphatase activity [PMID:9837904]
experiment: EXISTENCE:mutant phenotype:GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [PMID:9837904]
experiment: EXISTENCE:mutant phenotype:GO:0004805 trehalose-phosphatase activity [PMID:9837904]
experiment: EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:9837904]
experiment: EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]
note: Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
codon start: 1
product: trehalose 6-phosphate synthase/phosphatase complex subunit
translation: MALIVASLFLPYQPQFELDTSLPENSQVDSSLVNIQAMANDQQQQRALSNNISQESLVAPAPEQGVPPAISRSATRSPSAFNRASSTTNTATLDDLVSSDIFMENLTANATTSHTPTSKTMLKPRKNGSVERFFSPSSNIPTDRIASPIQHEHDSGSRIASPIQQQQQDPTTNLLKNVNKSLLVHSLLNNTSQTSLEGPNNHIVTPKSRAGNRPTSAATSLVNRTKQGSASSGSSGSSAPPSIKRITPHLTASAAKQRPLLAKQPSNLKYSELADISSSETSSQHNESDPDDLTTAPDEEYVSDLEMDDAKQDYKVPKFGGYSNKSKLKKYALLRSSQELFSRLPWSIVPSIKGNGAMKNAINTAVLENIIPHRHVKWVGTVGIPTDEIPENILANISDSLKDKYDSYPVLTDDDTFKAAYKNYCKQILWPTLHYQIPDNPNSKAFEDHSWKFYRNLNQRFADAIVKIYKKGDTIWIHDYHLMLVPQMVRDVLPFAKIGFTLHVSFPSSEVFRCLAQREKILEGLTGADFVGFQTREYARHFLQTSNRLLMADVVHDEELKYNGRVVSVRFTPVGIDAFDLQSQLKDGSVMQWRQLIRERWQGKKLIVCRDQFDRIRGIHKKLLAYEKFLVENPEYVEKSTLIQICIGSSKDVELERQIMIVVDRINSLSTNISISQPVVFLHQDLDFSQYLALSSEADLFVVSSLREGMNLTCHEFIVCSEDKNAPLLLSEFTGSASLLNDGAIIINPWDTKNFSQAILKGLEMPFDKRRPQWKKLMKDIINNDSTNWIKTSLQDIHISWQFNQEGSKIFKLNTKTLMEDYQSSKKRMFVFNIAEPPSSRMISILNDMTSKGNIVYIMNSFPKPILENLYSRVQNIGLIAENGAYVSLNGVWYNIVDQVDWRNDVAKILEDKVERLPGSYYKINESMIKFHTENAEDQDRVASVIGDAITHINTVFDHRGIHAYVYKNVVSVQQVGLSLSAAQFLFRFYNSASDPLDTSSGQITNIQTPSQQNPSDQEQQPPASPTVSMNHIDFACVSGSSSPVLEPLFKLVNDEASEGQVKAGHAIVYGDATSTYAKEHVNGLNELFTIISRIIED
SIO_010081: YML100W
subclass of: SO_0000673
so part of: YML100W
location: 70624..73920
location: region:70624-73920:1
so has part: feature:70624-73920:1:exon

NP_013608.1
type: Protein
SIO_000068: ncbiprotein

S000004566
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70624-73920:1:exon

YML099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARGR2
gene: ARG81
locus tag: YML099C
gene synonym: ARGR2
so part of: sequence
location: complement(<74398..>77040)
location: region:74398-77040:-1
so has part: feature:74398-77040:-1:exon
subclass of: SO_0000010

854874
type: Gene
SIO_000068: ncbigene

position:74398:-1
position: 74398
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77040:-1
position: 77040
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74398-77040:-1:exon

YML099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARGR2
gene: ARG81
locus tag: YML099C
gene synonym: ARGR2
product: Arg81p
transcript id: NM_001182459.1
SIO_010081: YML099C
subclass of: SO_0000673
so part of: YML099C
location: complement(<74398..>77040)
location: region:74398-77040:-1
so has part: feature:74398-77040:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74398-77040:-1:exon

YML099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARGR2
gene: ARG81
locus tag: YML099C
gene synonym: ARGR2
experiment: EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:10688655]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3311884]
experiment: EXISTENCE:mutant phenotype:GO:0000821 regulation of arginine metabolic process [PMID:10688655]
note: Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
codon start: 1
product: Arg81p
translation: MGISSKNGPKKMGRAKTFTGCWTCRGRKVKCDLRHPHCQRCEKSNLPCGGYDIKLRWSKPMQFDPYGVPIPQNSPATTTNLSGSVDEPQYQRRNIDFVRYDEEYVYHEDMDDELTMLHTPPIEKISDNKTWIIKKFGVFKGTDKIDKQYAPRKKRNRKRVAKSLESSASISLSSLPSSSTISFPIRHIEDKLRNKGHVKTGILSANDGVPPTPNLLDYDWNNLNITGYEWISSELRDDALLSAVTLQGHHLGHTQPQEISLEENSNVVSGEEHVNAKEHGCAFEADNQGSSTLPNKAASANDKLYQQNLKLLFQKNSSNSEEPDPQALIDDVFVNIEPRSLPASDLNKITLAPPNEESRMPKSMLELTSYSSDLPPELVDIIPKTDLTVHGLARFLLNHYFNNVADKMTVVVLEKNPWKTLYFPRALMALGDLAGLGQSSNSRNALLNALLAVSCFHLQSKYPRNYKLQKYFLGLGIELRNQASNFLRLCLNTKSSIPEKYKDVLTAILSMNSIDVVWGTMADCQDHLALCEDFVESRMKLRPNISEKTKTLHRIFSFLKLIQDSTALDKVRAKEIVILPSEEDDNYKPLDTSNATTSSSEPRVDVVQEGLFREALNENDGKIHIEFVKEPITNVSADSTPSSTTPPIFTNIATESYYNKSDISKLVSKTDENIIGTDSLYGLPNSLILLFSDCVRIVRHNEYYNLTYLPVPRKFNELSLNFEKRLLKWKSEWNFHQENSEGKSFINSTAEALYHHTMSFYFSLIIYYFTMARSLNCQFLQNYVAKVLDHLNAMEELVDQKKVKIVPLIWQGFMAGCACTDENRQQEFRRWAAKLAESGVGSYWGARQVMLEVWRRRKEDEPGDNWYSVYKDWEMNLMLS
SIO_010081: YML099C
subclass of: SO_0000673
so part of: YML099C
location: complement(74398..77040)
location: region:74398-77040:-1
so has part: feature:74398-77040:-1:exon

NP_013610.1
type: Protein
SIO_000068: ncbiprotein

S000004565
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74398-77040:-1:exon

YML098W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FUN81
alternative label: TAF19
gene: TAF13
locus tag: YML098W
gene synonym: FUN81; TAF19
so part of: sequence
location: <77267..>77770
location: region:77267-77770:1
so has part: feature:77267-77770:1:exon
subclass of: SO_0000010

854875
type: Gene
SIO_000068: ncbigene

position:77267:1
position: 77267
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77770:1
position: 77770
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77267-77770:1:exon

YML098W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FUN81
alternative label: TAF19
gene: TAF13
locus tag: YML098W
gene synonym: FUN81; TAF19
product: Taf13p
transcript id: NM_001182458.1
SIO_010081: YML098W
subclass of: SO_0000673
so part of: YML098W
location: <77267..>77770
location: region:77267-77770:1
so has part: feature:77267-77770:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77267-77770:1:exon

YML098W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FUN81
alternative label: TAF19
gene: TAF13
locus tag: YML098W
gene synonym: FUN81; TAF19
experiment: EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity []
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]
note: TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
codon start: 1
product: Taf13p
translation: MSRKLKKTNLFNKDVSSLLYAYGDVPQPLQATVQCLDELVSGYLVDVCTNAFHTAQNSQRNKLRLEDFKFALRKDPIKLGRAEELIATNKLITEAKKQFNETDNQNSLKRYREEDEEGDEMEEDEDEQQVTDDDEEAAGRNSAKQSTDSKATKIRKQGPKNLKKTKK
SIO_010081: YML098W
subclass of: SO_0000673
so part of: YML098W
location: 77267..77770
location: region:77267-77770:1
so has part: feature:77267-77770:1:exon

NP_013611.1
type: Protein
SIO_000068: ncbiprotein

S000004564
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77267-77770:1:exon

YML097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VPL31
alternative label: VPT9
gene: VPS9
locus tag: YML097C
gene synonym: VPL31; VPT9
so part of: sequence
location: complement(<78335..>79690)
location: region:78335-79690:-1
so has part: feature:78335-79690:-1:exon
subclass of: SO_0000010

854876
type: Gene
SIO_000068: ncbigene

position:78335:-1
position: 78335
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79690:-1
position: 79690
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78335-79690:-1:exon

YML097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VPL31
alternative label: VPT9
gene: VPS9
locus tag: YML097C
gene synonym: VPL31; VPT9
product: guanine nucleotide exchange factor VPS9
transcript id: NM_001182457.1
SIO_010081: YML097C
subclass of: SO_0000673
so part of: YML097C
location: complement(<78335..>79690)
location: region:78335-79690:-1
so has part: feature:78335-79690:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78335-79690:-1:exon

YML097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VPL31
alternative label: VPT9
gene: VPS9
locus tag: YML097C
gene synonym: VPL31; VPT9
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10329739|PMID:23612966]
experiment: EXISTENCE:direct assay:GO:0005769 early endosome [PMID:31754649]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8628304|PMID:23612966|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]
experiment: EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8628304]
experiment: EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:22748138|PMID:23612966]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]
note: Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain
codon start: 1
product: guanine nucleotide exchange factor VPS9
translation: MTDDEKREILKEFDPFSQLEQANGNPDKDVKFKKDDPNRAAAEETNRDISAQDKGDEEPFYDFQIFIKQLQTPGADPLVKYTKSFLRNFLAQRLLWTVSEEIKLISDFKTFIYDKFTLYEPFRSLDNSKMRNAKEGMEKLIMGKLYSRCFSPSLYEILQKPLDDEHMKDLTNDDTLLEKIRHYRFISPIMLDIPDTMPNARLNKFVHLASKELGKINRFKSPRDKMVCVLNASKVIFGLLKHTKLEQNGADSFIPVLIYCILKGQVRYLVSNVNYIERFRSPDFIRGEEEYYLSSLQAALNFIMNLTERSLTIEDHEDFEEAYQRNFKQLAEEKEEEEKKKQLEIPDELQPNGTLLKPLDEVTNIVISKFNELFSPIGEPTQEEALKSEQSNKEEDVSSLIKKIEENERKDTLNTLQNMFPDMDPSLIEDVCIAKKSRIGPCVDALLSLSE
SIO_010081: YML097C
subclass of: SO_0000673
so part of: YML097C
location: complement(78335..79690)
location: region:78335-79690:-1
so has part: feature:78335-79690:-1:exon

NP_013612.1
type: Protein
SIO_000068: ncbiprotein

S000004563
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78335-79690:-1:exon

YML096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML096W
so part of: sequence
location: <79909..>81486
location: region:79909-81486:1
so has part: feature:79909-81486:1:exon
subclass of: SO_0000010

854877
type: Gene
SIO_000068: ncbigene

position:79909:1
position: 79909
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:81486:1
position: 81486
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:79909-81486:1:exon

YML096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML096W
product: putative asparagine synthase
transcript id: NM_001182456.1
SIO_010081: YML096W
subclass of: SO_0000673
so part of: YML096W
location: <79909..>81486
location: region:79909-81486:1
so has part: feature:79909-81486:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:79909-81486:1:exon

YML096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML096W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
codon start: 1
product: putative asparagine synthase
translation: MCGILLHYCPNNNYLNDELIEFPEGTEFGDTTCTNESSIFNKIIPYIAARGPNYSSLRAVKAYRISWFSSVLSLRQPFTKQSINVDDRYFLQFNGELYNKEISQGDNDSLYIASMLQNLKEGMGVIDVIKSLEGEYAYTIYDVNSSKLYFGRDPIGRRSLSYSVTPDNELYVASVTGSAGSFQDCIGGVIYEYDTRTKLLNSNQRSHLPYEVTSEIDLNFTSLSEVSKNLYAVLRDSVKKRVESIHPRHIENSPIAVLFSGGIDCSVIVALICEVLQENDYKCGKPVIELLNVSFENPRTGLFPSDTPDRKLSINSAKTLQNLYPNVDIKLVEVDVPYDEYLKWKPFVINLMYPKQTEMDLSIAIAFFFASRGRGFLTSLNGERTPYQRHGIVLFSGLGADELYGGYHKFANKPPHELVEELTRQINNIYDRNLNRDDKVIAHNGVEVRYPFLDEYVIKLSTAEIPINFKVNKLILRKVASQYLKLDGISSEPKRAIQFGAKSAKMTKDGNKHGTDLLKENRNCS
SIO_010081: YML096W
subclass of: SO_0000673
so part of: YML096W
location: 79909..81486
location: region:79909-81486:1
so has part: feature:79909-81486:1:exon

NP_013613.1
type: Protein
SIO_000068: ncbiprotein

S000004562
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:79909-81486:1:exon

YML095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD10
locus tag: YML095C
so part of: sequence
location: complement(<81481..>82113)
location: region:81481-82113:-1
so has part: feature:81481-82113:-1:exon
subclass of: SO_0000010

854878
type: Gene
SIO_000068: ncbigene

position:81481:-1
position: 81481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82113:-1
position: 82113
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81481-82113:-1:exon

YML095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD10
locus tag: YML095C
product: DNA repair protein RAD10
transcript id: NM_001182454.1
SIO_010081: YML095C
subclass of: SO_0000673
so part of: YML095C
location: complement(<81481..>82113)
location: region:81481-82113:-1
so has part: feature:81481-82113:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81481-82113:-1:exon

YML095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD10
locus tag: YML095C
experiment: EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:8253764]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:1741062]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852079]
experiment: EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:7559571]
experiment: EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:11514439]
experiment: EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:7891718]
experiment: EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:7891718]
experiment: EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]
experiment: EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:2188090]
experiment: EXISTENCE:physical interaction:GO:0000110 nucleotide-excision repair factor 1 complex [PMID:8621533]
note: Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
codon start: 1
product: DNA repair protein RAD10
translation: MNNTDPTSFESILAGVAKLRKEKSGADTTGSQSLEIDASKLQQQEPQTSRRINSNQVINAFNQQKPEEWTDSKATDDYNRKRPFRSTRPGKTVLVNTTQKENPLLNHLKSTNWRYVSSTGINMIYYDYLVRGRSVLFLTLTYHKLYVDYISRRMQPLSRNENNILIFIVDDNNSEDTLNDITKLCMFNGFTLLLAFNFEQAAKYIEYLNL
SIO_010081: YML095C
subclass of: SO_0000673
so part of: YML095C
location: complement(81481..82113)
location: region:81481-82113:-1
so has part: feature:81481-82113:-1:exon

NP_013614.1
type: Protein
SIO_000068: ncbiprotein

S000004560
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81481-82113:-1:exon

YML094W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PFD5
gene: GIM5
locus tag: YML094W
gene synonym: PFD5
so part of: sequence
location: <82275..>82849
location: region:82275-82849:1
so has part: feature:82275-82849:1:exon
subclass of: SO_0000010

854879
type: Gene
SIO_000068: ncbigene

position:82275:1
position: 82275
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82849:1
position: 82849
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:82275-82849:1:exon

YML094W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PFD5
gene: GIM5
locus tag: YML094W
gene synonym: PFD5
product: Gim5p
transcript id: NM_001182453.1
SIO_010081: YML094W
subclass of: SO_0000673
so part of: YML094W
location: join(<82275..82290,82374..>82849)
location: region:82275-82849:1
so has part: feature:82275-82290:1:exon
so has part: feature:82374-82849:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:82275-82290:1:exon

position:82290:1
position: 82290
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:82374-82849:1:exon

position:82374:1
position: 82374
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML094W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PFD5
gene: GIM5
locus tag: YML094W
gene synonym: PFD5
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:24068951]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]
experiment: EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]
note: Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
codon start: 1
product: Gim5p
translation: MSSQKIDLTKLNPEQLNAVKQQFDQELQHFTQSLQALTMAKGKFTECIDDIKTVSQAGNEGQKLLVPASASLYIPGKIVDNKKFMVDIGTGYYVEKSAEAAIAFYQKKVDKLNKESVQIQDIIKEKTQYSLSIEAQIRQAAIRQHEAMSKQQQQQQKKESSTA
SIO_010081: YML094W
subclass of: SO_0000673
so part of: YML094W
location: join(82275..82290,82374..82849)
location: region:82275-82849:1
so has part: feature:82275-82290:1:exon
so has part: feature:82374-82849:1:exon

NP_013616.1
type: Protein
SIO_000068: ncbiprotein

S000004559
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:82275-82290:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:82374-82849:1:exon

YML093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP14
locus tag: YML093W
so part of: sequence
location: <83090..>85789
location: region:83090-85789:1
so has part: feature:83090-85789:1:exon
subclass of: SO_0000010

854881
type: Gene
SIO_000068: ncbigene

position:83090:1
position: 83090
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85789:1
position: 85789
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:83090-85789:1:exon

YML093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP14
locus tag: YML093W
product: Utp14p
transcript id: NM_001182452.1
SIO_010081: YML093W
subclass of: SO_0000673
so part of: YML093W
location: <83090..>85789
location: region:83090-85789:1
so has part: feature:83090-85789:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:83090-85789:1:exon

YML093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP14
locus tag: YML093W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit
codon start: 1
product: Utp14p
translation: MAKKKSKSRSKSSRRVLDALQLAEREINGEFDNSSDNDKRHDARRNGTVVNLLKRSKGDTNSDEDDIDSESFEDEELNSDEALGSDDDYDILNSKFSQTIRDKKENANYQEEEDEGGYTSIDEEDLMPLSQVWDMDEKTAQSNGNDDEDASPQLKLQDTDISSESSSSEESESESEDDEEEEDPFDEISEDEEDIELNTITSKLIDETKSKAPKRLDTYGSGEANEYVLPSANAASGASGKLSLTDMMNVIDDRQVIENANLLKGKSSTYEVPLPQRIQQRHDRKAAYEISRQEVSKWNDIVQQNRRADHLIFPLNKPTEHNHASAFTRTQDVPQTELQEKVDQVLQESNLANPEKDSKFEELSTAKMTPEEMRKRTTEMRLMRELMFREERKARRLKKIKSKTYRKIKKKELMKNRELAAVSSDEDNEDHDIARAKERMTLKHKTNSKWAKDMIKHGMTNDAETREEMEEMLRQGERLKAKMLDRNSDDEEDGRVQTLSDVENEEKENIDSEALKSKLGKTGVMNMAFMKNGEAREREANKETLRQLRAVENGDDIKLFESDEEETNGENIQINKGRRIYTPGSLESNKDMNELNDHTRKENKVDESRSLENRLRAKNSGQSKNARTNAEGAIIVEEESDGEPLQDGQNNQQDEEAKDVNPWLANESDEEHTVKKQSSKVNVIDKDSSKNVKAMNKMEKAELKQKKKKKGKSNDDEDLLLTADDSTRLKIVDPYGGSDDEQGDNVFMFKQQDVIAEAFAGDDVVAEFQEEKKRVIDDEDDKEVDTTLPGWGEWAGAGSKPKNKKRKFIKKVKGVVNKDKRRDKNLQNVIINEKVNKKNLKYQSSAVPFPFENREQYERSLRMPIGQEWTSRASHQELIKPRIMTKPGQVIDPLKAPFK
SIO_010081: YML093W
subclass of: SO_0000673
so part of: YML093W
location: 83090..85789
location: region:83090-85789:1
so has part: feature:83090-85789:1:exon

NP_013617.1
type: Protein
SIO_000068: ncbiprotein

S000004558
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:83090-85789:1:exon

YML092C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRE8
locus tag: YML092C
so part of: sequence
location: complement(<85987..>86739)
location: region:85987-86739:-1
so has part: feature:85987-86739:-1:exon
subclass of: SO_0000010

854882
type: Gene
SIO_000068: ncbigene

position:85987:-1
position: 85987
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:86739:-1
position: 86739
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85987-86739:-1:exon

YML092C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRE8
locus tag: YML092C
product: proteasome core particle subunit alpha 2
transcript id: NM_001182451.1
SIO_010081: YML092C
subclass of: SO_0000673
so part of: YML092C
location: complement(<85987..>86739)
location: region:85987-86739:-1
so has part: feature:85987-86739:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85987-86739:-1:exon

YML092C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRE8
locus tag: YML092C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
note: Alpha 2 subunit of the 20S proteasome
codon start: 1
product: proteasome core particle subunit alpha 2
translation: MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL
SIO_010081: YML092C
subclass of: SO_0000673
so part of: YML092C
location: complement(85987..86739)
location: region:85987-86739:-1
so has part: feature:85987-86739:-1:exon

NP_013618.1
type: Protein
SIO_000068: ncbiprotein

S000004557
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85987-86739:-1:exon

YML091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPM2
locus tag: YML091C
so part of: sequence
location: complement(<87123..>90731)
location: region:87123-90731:-1
so has part: feature:87123-90731:-1:exon
subclass of: SO_0000010

854883
type: Gene
SIO_000068: ncbigene

position:87123:-1
position: 87123
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:90731:-1
position: 90731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87123-90731:-1:exon

YML091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPM2
locus tag: YML091C
product: ribonuclease P
transcript id: NM_001182450.1
SIO_010081: YML091C
subclass of: SO_0000673
so part of: YML091C
location: complement(<87123..>90731)
location: region:87123-90731:-1
so has part: feature:87123-90731:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87123-90731:-1:exon

YML091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPM2
locus tag: YML091C
EC number: 3.1.26.5
experiment: EXISTENCE:direct assay:GO:0001682 tRNA 5'-leader removal [PMID:8366116]
experiment: EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:8366116]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16024791]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:7544434]
experiment: EXISTENCE:direct assay:GO:0030677 ribonuclease P complex [PMID:8366116]
experiment: EXISTENCE:direct assay:GO:0030678 mitochondrial ribonuclease P complex [PMID:3537697]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024791]
experiment: EXISTENCE:genetic interaction:GO:0006397 mRNA processing [PMID:17267405]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11404323]
experiment: EXISTENCE:mutant phenotype:GO:0006396 RNA processing [PMID:11522833]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11404323]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024791]
experiment: EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]
experiment: EXISTENCE:physical interaction:GO:0006397 mRNA processing [PMID:17267405]
note: Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
codon start: 1
product: ribonuclease P
translation: MAFKSFIYSKGYHRSAAQKKTATSFFDSSYQYLRQNQGLVNSDPVLHASHLHPHPVVVANVNYNNVDDILHPHDLDSSINNTNNPLTHEELLYNQNVSLRSLKQQQSTNYVNNNNNNQHRYYSTGPTLPTNQYDPLNFSNRNFQDLSLKTSQPSVQQPQNEYSLLKDENAPVWKEDTEPCLNKSTYLQTHIDEINRCYEQKNYNKINSLYQSLKRNDIVPPLEIFTKVLDSLCKRPLDNNDLDNKMYELLTCYQDMINNRLKPPDEIYNIVLLSLFKGSILAYQFENPNGSDFYKIAIELFNTTTNDPKQKSVVKFRNFSKDVLDYNLLAMNIYPGHITLSKAQQVIKSSPAFIKDSFYFIACFSYAKLTNDKFAIKELYEDFRLSLSSGSPDQGLFDDQFEIYSVILSSFIETGEVELATNLLDDLVSKIQSSNGLASNISLLLSSFLISMSKVDPSKAYEIWFKFHNLNWIPEFSYEFYLVFMANSFQDWNLTKKIYDYIFPMERNLSPLKKQKLSDYLLHPIGVDSITTSLLDYSLQLKDNEVIMKILEESIVKNFSFDIGIYPFVFNYLREIQCGEDYLMRFIESHAEFIKKSNSINKFQFLNMIVDNFQSQSLLNKISHAKFFKNFVEDFNLENCELVSYNGLISCINNFIKIPKTIKDFPYILEIHAILVTKLFDFDTYPILQNGNNEVLLKFRDQIEHQFKMLAQNFCRLNLDPNLLAGVVSQAMKMVNLDDTANGQDLLNFFNHPGDWDKSYPLSLGSFIRNSPRGGIREFTKLSKEGYCFDYDTYKELIIKRAINKQIIDKCLEVCPDSIELKNIVNLMISKIPGRNLTQLIINNPKFSKVFVPNLRNDSMLKLIENCESLSNFIRICDFPEKFKSIAIQAENKNAIELIYERLFDGGKYADILRYNNIVPVLNLELLLKSCIRSGEFKKYESLSKKFNDKISESSKIDIQLEYLINKNDLKGAFTLFEKTPRELRTPHKTMDLYTFALFLDSFNRNITYYESPENTLQFANILSSQTSFINLLSTYNLIAHSDHLMNFNVGGMAAKVKKEILNQMLNNLYDSIRLLSPSIENDKSMKEKLREKVKNYCRFKAYLKSPELDMDELKTLVSVESFLNPFTPSMLFNNLIETIYINEHASSLVLQNGLIYSLQQKGLNKILSYLEESFITSGNDANIEKVREFRSLLRKSKPLQA
SIO_010081: YML091C
subclass of: SO_0000673
so part of: YML091C
location: complement(87123..90731)
location: region:87123-90731:-1
so has part: feature:87123-90731:-1:exon

NP_013619.1
type: Protein
SIO_000068: ncbiprotein

S000004556
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87123-90731:-1:exon

YNCM0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZOD1
locus tag: YNCM0003W
so part of: sequence
location: 91970..92027
location: region:91970-92027:1
so has part: feature:91970-92027:1:exon
subclass of: SO_0000011

23547382
type: Gene
SIO_000068: ncbigene

position:91970:1
position: 91970
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:92027:1
position: 92027
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91970-92027:1:exon

YNCM0003W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: other
gene: ZOD1
locus tag: YNCM0003W
product: ZOD1
note: tDNA relic, ancient tDNA for tRNA-Ile; weakly transcribed by RNA polymerase III; located upstream of UFO1; associated with components of the Pol III machinery: Tfc4p, Brf1p, Bdp1, and Rpc34p
transcript id: NR_132235.1
SIO_010081: YNCM0003W
subclass of: SO_0000673
so part of: YNCM0003W
location: 91970..92027
location: region:91970-92027:1
so has part: feature:91970-92027:1:exon

S000077071
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:91970-92027:1:exon

YML088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UFO1
locus tag: YML088W
so part of: sequence
location: <92235..>94241
location: region:92235-94241:1
so has part: feature:92235-94241:1:exon
subclass of: SO_0000010

854886
type: Gene
SIO_000068: ncbigene

position:92235:1
position: 92235
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:94241:1
position: 94241
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92235-94241:1:exon

YML088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UFO1
locus tag: YML088W
product: SCF ubiquitin ligase complex subunit UFO1
transcript id: NM_001182447.1
SIO_010081: YML088W
subclass of: SO_0000673
so part of: YML088W
location: <92235..>94241
location: region:92235-94241:1
so has part: feature:92235-94241:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92235-94241:1:exon

YML088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UFO1
locus tag: YML088W
experiment: EXISTENCE:curator inference:GO:0004842 ubiquitin-protein transferase activity [PMID:14506225|PMID:14747994]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14506225]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14506225|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:11283612|PMID:14747994]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:10963670]
experiment: EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10963670]
experiment: EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14506225|PMID:14747994]
experiment: EXISTENCE:physical interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:14506225]
note: F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation
codon start: 1
product: SCF ubiquitin ligase complex subunit UFO1
translation: MERPGLVLQDLPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNLFKSRVHTTHFPTFSQSSKFSVEYIERTRGLHHWQHNKAIRTKYTIIPTRNWDQPSIERIVFDYPRVAAYNDGTITILQLQNHKRQKKFKKLIYIPCTTPQGCSTMDFNINAAVFGRFDGRVFGKLLSNKSYLTPVMEFTGRHSAGVTAICNSESWDTSREDWSVSGSENGEIIWWCENKLVKMWKVSNRVIWKLAFFKDWTLIMDDEKLYIIHQMQELHSIDIPKDLDEQPMRVRFFKMDFGSMTLVLADLNNVYTISVNPNGNFGNLRKLEMPEQICAVEIDEKTSQREQNWQFAGDDGCYISLLTTQNTLYIINIRDLSSSGLKVQCKISFDEQVYVSQVTNLIVVVALPNVLQILNAMTGELIKTVLKTEKFPEFLKVSQDKIIMGSGNVLNYLKFVSSDSKKHHHSTKGKNTVSNKWNETLNTELQYYDEDEDLRRKRQSEISRLIDAYGGDLELSGDTDEENDIQLRIALLESQEAQARNQAEAGEPVGDDEDEQLRRALEESQLIYETQTNSSANHGNNTNDEIDEDDEEFLRAIRQSRVEDERRRHLRNHTTGRRNGPLSDDNFATYGAAESSERTSTENTIGSSVGVDASNNVDEDLQLAIALSLSEIN
SIO_010081: YML088W
subclass of: SO_0000673
so part of: YML088W
location: 92235..94241
location: region:92235-94241:1
so has part: feature:92235-94241:1:exon

NP_013622.1
type: Protein
SIO_000068: ncbiprotein

S000004553
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92235-94241:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1305; Autonomously Replicating Sequence
so part of: sequence
location: 94217..94463
location: region:94217-94463:1
so has part: feature:94217-94463:1:region

S000118366
type: SGD
SIO_000068: sgd

position:94217:1
position: 94217
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:94463:1
position: 94463
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94217-94463:1:region

YML087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM33
locus tag: YML087C
so part of: sequence
location: complement(<94431..>95369)
location: region:94431-95369:-1
so has part: feature:94431-95369:-1:exon
subclass of: SO_0000010

854887
type: Gene
SIO_000068: ncbigene

position:94431:-1
position: 94431
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:95369:-1
position: 95369
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94431-95369:-1:exon

YML087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM33
locus tag: YML087C
product: cytochrome-b5 reductase
transcript id: NM_001182446.1
SIO_010081: YML087C
subclass of: SO_0000673
so part of: YML087C
location: complement(<94431..>95369)
location: region:94431-95369:-1
so has part: feature:94431-95369:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94431-95369:-1:exon

YML087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM33
locus tag: YML087C
note: hypothetical protein, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
codon start: 1
product: cytochrome-b5 reductase
translation: MSIVETCISFVSTNPFYPFCTGLLLNCVVTPLYFWKTQNGRIVVVSLLQFVVLYATAFISIGTDKSLYRNKWVALPLSKKTRISRNTSLYCFKLKYPFERLHIPMGYHLAVRVTINGERLVRYYTPVNVPNTEGHLELVVKTYKHGVVSKYFDKLKIRQYVEFKGPLGELEYDQDTATELGIIAGGSGITPVLQVLQEIIPSPEDLTHISLIYANETEDDILMKSQLDHMAKEYPHFKVHYVIHKPNGKWNGDVGYVTLEEMKRYLPKQAEDHRLLICGPPKMNEMVLNYAKELGWSNGFHKGNGTDKVFVF
SIO_010081: YML087C
subclass of: SO_0000673
so part of: YML087C
location: complement(94431..95369)
location: region:94431-95369:-1
so has part: feature:94431-95369:-1:exon

NP_013623.1
type: Protein
SIO_000068: ncbiprotein

S000004552
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94431-95369:-1:exon

YML086C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALO1
locus tag: YML086C
so part of: sequence
location: complement(<95791..>97371)
location: region:95791-97371:-1
so has part: feature:95791-97371:-1:exon
subclass of: SO_0000010

854888
type: Gene
SIO_000068: ncbigene

position:95791:-1
position: 95791
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97371:-1
position: 97371
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:95791-97371:-1:exon

YML086C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALO1
locus tag: YML086C
product: D-arabinono-1,4-lactone oxidase
transcript id: NM_001182445.1
SIO_010081: YML086C
subclass of: SO_0000673
so part of: YML086C
location: complement(<95791..>97371)
location: region:95791-97371:-1
so has part: feature:95791-97371:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:95791-97371:-1:exon

YML086C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALO1
locus tag: YML086C
EC number: 1.1.3.37
experiment: EXISTENCE:direct assay:GO:0003885 D-arabinono-1,4-lactone oxidase activity [PMID:10094636]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10094636|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:16407407]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10094636]
experiment: EXISTENCE:mutant phenotype:GO:0070485 dehydro-D-arabinono-1,4-lactone biosynthetic process [PMID:10094636]
note: D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon
codon start: 1
product: D-arabinono-1,4-lactone oxidase
translation: MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWWYPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDVNVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWAKNFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD
SIO_010081: YML086C
subclass of: SO_0000673
so part of: YML086C
location: complement(95791..97371)
location: region:95791-97371:-1
so has part: feature:95791-97371:-1:exon

NP_013624.1
type: Protein
SIO_000068: ncbiprotein

S000004551
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:95791-97371:-1:exon

YML085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TUB1
locus tag: YML085C
so part of: sequence
location: complement(<97941..>99400)
location: region:97941-99400:-1
so has part: feature:97941-99400:-1:exon
subclass of: SO_0000010

854889
type: Gene
SIO_000068: ncbigene

position:97941:-1
position: 97941
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99400:-1
position: 99400
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97941-99400:-1:exon

YML085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TUB1
locus tag: YML085C
product: alpha-tubulin TUB1
transcript id: NM_001182444.1
SIO_010081: YML085C
subclass of: SO_0000673
so part of: YML085C
location: complement(join(<97941..99259,99376..>99400))
location: region:97941-99400:-1
so has part: feature:99376-99400:-1:exon
so has part: feature:97941-99259:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99376-99400:-1:exon

position:99376:-1
position: 99376
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:97941-99259:-1:exon

position:99259:-1
position: 99259
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TUB1
locus tag: YML085C
experiment: EXISTENCE:curator inference:GO:0005827 polar microtubule [PMID:9488492]
experiment: EXISTENCE:curator inference:GO:0005828 kinetochore microtubule [PMID:9488492]
experiment: EXISTENCE:curator inference:GO:0005880 nuclear microtubule [PMID:9488492]
experiment: EXISTENCE:curator inference:GO:0005881 cytoplasmic microtubule [PMID:9488492]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0045298 tubulin complex [PMID:9488492]
experiment: EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:16582437]
experiment: EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:16582437]
experiment: EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:16582437]
experiment: EXISTENCE:physical interaction:GO:0045298 tubulin complex [PMID:9488492]
note: Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
codon start: 1
product: alpha-tubulin TUB1
translation: MREVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDAANNYARGHYTVGREILGDVLDRIRKLADQCDGLQGFLFTHSLGGGTGSGLGSLLLEELSAEYGKKSKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYSPVLSKSKAFHESNSVSEITNACFEPGNQMVKCDPRDGKYMATCLLYRGDVVTRDVQRAVEQVKNKKTVQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDRKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEEEF
SIO_010081: YML085C
subclass of: SO_0000673
so part of: YML085C
location: complement(join(97941..99259,99376..99400))
location: region:97941-99400:-1
so has part: feature:99376-99400:-1:exon
so has part: feature:97941-99259:-1:exon

NP_013625.1
type: Protein
SIO_000068: ncbiprotein

S000004550
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99376-99400:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:97941-99259:-1:exon

YML083C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML083C
so part of: sequence
location: complement(<99794..>101050)
location: region:99794-101050:-1
so has part: feature:99794-101050:-1:exon
subclass of: SO_0000010

854891
type: Gene
SIO_000068: ncbigene

position:99794:-1
position: 99794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:101050:-1
position: 101050
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99794-101050:-1:exon

YML083C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML083C
product: uncharacterized protein
transcript id: NM_001182442.1
SIO_010081: YML083C
subclass of: SO_0000673
so part of: YML083C
location: complement(<99794..>101050)
location: region:99794-101050:-1
so has part: feature:99794-101050:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99794-101050:-1:exon

YML083C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML083C
note: hypothetical protein; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
codon start: 1
product: uncharacterized protein
translation: MDYLHVYNNNQAHVPRTPPGRQCLSPVLPPIILALDQQHSLTFGYSSPRCLPTPILPSMSTNTPVHWSQQVVTIPVAVRNHAAMMPIITPMTSPRPQFEATAPSPPLAPVAIKLPDLKLPPSPVPSTVEDRVSHPILPKIVIGNGGGRDVERDSTEELIRKIPNYIGCAKTKAQLSKVRSGKQLIACAQEYHHPVNKDEIENINNILNFRDFIFKHPKSSFEFLCTLSFEQFVRVYSFISFIYRTKKINKNKYELVCEMNVHEQLSNKRIQRTRTPEKYKIHLICESKLILTFNHCTKTVKFESINGGHCHPISANHIIKPSLFLTHCINKCYQTVSDPTDLKLALRDALEALDHERIGLSFLKRRHFKCSHQASSLSNASATLKKQEDHDTFGVHTGIIHTANFFMFNASSDIFQRN
SIO_010081: YML083C
subclass of: SO_0000673
so part of: YML083C
location: complement(99794..101050)
location: region:99794-101050:-1
so has part: feature:99794-101050:-1:exon

NP_013627.1
type: Protein
SIO_000068: ncbiprotein

S000004548
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99794-101050:-1:exon

YML082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML082W
so part of: sequence
location: <101862..>103811
location: region:101862-103811:1
so has part: feature:101862-103811:1:exon
subclass of: SO_0000010

854892
type: Gene
SIO_000068: ncbigene

position:101862:1
position: 101862
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:103811:1
position: 103811
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:101862-103811:1:exon

YML082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML082W
product: putative cystathionine gamma-synthase
transcript id: NM_001182441.1
SIO_010081: YML082W
subclass of: SO_0000673
so part of: YML082W
location: <101862..>103811
location: region:101862-103811:1
so has part: feature:101862-103811:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:101862-103811:1:exon

YML082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML082W
EC number: 2.5.1.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication
codon start: 1
product: putative cystathionine gamma-synthase
translation: MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLGCLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNGKVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYVLHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEENYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEPIEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSRNGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLFSLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDKTVEI
SIO_010081: YML082W
subclass of: SO_0000673
so part of: YML082W
location: 101862..103811
location: region:101862-103811:1
so has part: feature:101862-103811:1:exon

NP_013628.1
type: Protein
SIO_000068: ncbiprotein

S000004547
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:101862-103811:1:exon

YML081C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP18
locus tag: YML081C-A
so part of: sequence
location: complement(<103983..>104162)
location: region:103983-104162:-1
so has part: feature:103983-104162:-1:exon
subclass of: SO_0000010

854893
type: Gene
SIO_000068: ncbigene

position:103983:-1
position: 103983
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:104162:-1
position: 104162
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:103983-104162:-1:exon

YML081C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP18
locus tag: YML081C-A
product: F1F0 ATP synthase subunit i
transcript id: NM_001184340.1
SIO_010081: YML081C-A
subclass of: SO_0000673
so part of: YML081C-A
location: complement(<103983..>104162)
location: region:103983-104162:-1
so has part: feature:103983-104162:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:103983-104162:-1:exon

YML081C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP18
locus tag: YML081C-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005753 mitochondrial proton-transporting ATP synthase complex [PMID:20219971]
experiment: EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]
experiment: EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]
experiment: EXISTENCE:mutant phenotype:GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [PMID:9867807]
experiment: EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9867807|PMID:9867878]
experiment: EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:20219971]
experiment: EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:9867807]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971]
note: Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
codon start: 1
product: F1F0 ATP synthase subunit i
translation: MLKRFPTPILKVYWPFFVAGAAVYYGMSKAADLSSNTKEFINDPRNPRFAKGGKFVEVD
SIO_010081: YML081C-A
subclass of: SO_0000673
so part of: YML081C-A
location: complement(103983..104162)
location: region:103983-104162:-1
so has part: feature:103983-104162:-1:exon

NP_013629.1
type: Protein
SIO_000068: ncbiprotein

S000007247
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:103983-104162:-1:exon

YML081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAF1
gene: TDA9
locus tag: YML081W
gene synonym: AAF1
so part of: sequence
location: <104777..>108532
location: region:104777-108532:1
so has part: feature:104777-108532:1:exon
subclass of: SO_0000010

854894
type: Gene
SIO_000068: ncbigene

position:104777:1
position: 104777
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108532:1
position: 108532
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:104777-108532:1:exon

YML081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAF1
gene: TDA9
locus tag: YML081W
gene synonym: AAF1
product: Tda9p
transcript id: NM_001182440.1
SIO_010081: YML081W
subclass of: SO_0000673
so part of: YML081W
location: <104777..>108532
location: region:104777-108532:1
so has part: feature:104777-108532:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:104777-108532:1:exon

YML081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAF1
gene: TDA9
locus tag: YML081W
gene synonym: AAF1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:16785442|PMID:19111667|PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:23240040]
note: Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
codon start: 1
product: Tda9p
translation: MSSEEFKGLPIKRDISSTIYADRPPALSAPPCVGATGNDKIQVLPIPKKSRTIKTDKPRPFLCHICTRGFVRQEHLKRHQRAHTNEKPFLCVFCGRCFARRDLVLRHQHKLHSALVSKESINSKDKTEIDAINDKNIIQIQGNKQTILPTPSNPLAKTAVQLKKAAKEKKNGKQGKLDLSPSYGANNHSTDVSPSVGNSSTPAVIEETDSSSHFPLPDTNIPTKSKRHASFSASSAFTYSSDNFQKLHQQAKSDFDELQESIPHQVGFSTPQLTAQQLIENAIESGVVDLETLDLPPFLSLDGLPPASSSAAVAASEQIDICPSSATDTISGANSTPNQAATAPPFQLPIARESSSLFLANTPYLSDFLTMGSSYGGSGGFAKSITADPSLDYFNYKNHSHPDSRHNNSSSGINYSNNKNNNESIEKSQNNSNVINETIDHTDIHAHHADAHDDSFIESEEWLSKFIMDSQIDNDLKLNINHFNDIGFNNLHPQNPTTHSEPRNMHNENRDMHRSASKFQSVSENISPREQMSLFKTKQNKAISKFLSDEKIPSTASPSSSASPVQFDKKNVDINEFLLDESVSNLFTTRQIDLFKKNVNLYSPLFQNQKDAVSSTSLTPSLTTQTATTQSGPGWTDSSQKLTFFTEQLRNLIIKENNLKSNLFPTVDELNHYVDLYQVEFHKYFPFIHLYSIIPSSENYPLVISISMIGALYGFHSTHALLLSKIARTRVRMFLENTRSNHDKTPIWLMQSLVLLTFTSIFSNDMNAFRTVNTQIMILVQLIKISKLNYPLENFIKPPIESDHVLEYQDNPAVLNQFKAQYNTREQINRNFKYFILAQSRIRICHIVLLISNLFKSLVDFDCCFHSIDLKCGVPCYNEVLFFCENSRTWNENLTRFNIVLDSKFSLIEVSNGESNYEKCLMYLSNGNPYLYKNAKISFKTLLSLLISIHEKINIERDALKDSYESDFHAKNVQWRMHSRPLVATMLKHWELLYIKNGGILALSDENLPIINTNPSFRLIIPLYFFAKLRKCLDIAPTLRCIWNQDWNSMNSSLEKVCYERESLREATEYAVSVITFWIDTVSVMKGKSTQTPIFTITCIFVSILVIAGYMRRLEDFAQNKNSDCMIGSLKSTDRILWLKAFKTLKRIESHLSEREYKLQTFAEFLRVPDNGSLDIESLDSSLIENTLNSHDVTNQALDIITRTRLSSRTLYCGARILGDTPVWPVSLLFAHALQSRAIYNINHRKSVNSV
SIO_010081: YML081W
subclass of: SO_0000673
so part of: YML081W
location: 104777..108532
location: region:104777-108532:1
so has part: feature:104777-108532:1:exon

NP_013630.1
type: Protein
SIO_000068: ncbiprotein

S000004546
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:104777-108532:1:exon

YML080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUS1
locus tag: YML080W
so part of: sequence
location: <108806..>110077
location: region:108806-110077:1
so has part: feature:108806-110077:1:exon
subclass of: SO_0000010

854895
type: Gene
SIO_000068: ncbigene

position:108806:1
position: 108806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110077:1
position: 110077
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108806-110077:1:exon

YML080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUS1
locus tag: YML080W
product: tRNA dihydrouridine synthase
transcript id: NM_001182439.1
SIO_010081: YML080W
subclass of: SO_0000673
so part of: YML080W
location: <108806..>110077
location: region:108806-110077:1
so has part: feature:108806-110077:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108806-110077:1:exon

YML080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUS1
locus tag: YML080W
EC number: 1.3.1.88
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:12003496]
experiment: EXISTENCE:direct assay:GO:0017150 tRNA dihydrouridine synthase activity [PMID:12003496]
experiment: EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]
experiment: EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]
note: Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
codon start: 1
product: tRNA dihydrouridine synthase
translation: MTEPALSSANNALMQKLTGRQLFDKIGRPTRIVAPMVDQSELAWRILSRRYGATLAYTPMLHAKLFATSKKYREDNWSSLDGSSVDRPLVVQFCANDPEYLLAAAKLVEDKCDAVDLNLGCPQGIAKKGHYGSFLMEEWDLIHNLINTLHKNLKVPVTAKIRIFDDCEKSLNYAKMVLDAGAQFLTVHGRVREQKGQKTGLANWETIKYLRDNLPKETVFFANGNILYPEDISRCMEHIGADAVMSAEGNLYNPGVFNVGQTKNKEKIFPRVDKIIREYFQIVKECQESKASKTAMKSHFFKILRPFLPHHTDIRSTLATMNAKATWEEWEEQVVKPVEKVVQEIFEQPDIAIKDEITIGEKQSWGGSYRTVPYWRCQPYFRPVNGITGDKRVMQGLIDESVNKKRKADVPLESADKKKDVKA
SIO_010081: YML080W
subclass of: SO_0000673
so part of: YML080W
location: 108806..110077
location: region:108806-110077:1
so has part: feature:108806-110077:1:exon

NP_013631.1
type: Protein
SIO_000068: ncbiprotein

S000004545
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108806-110077:1:exon

YML079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CFF1
locus tag: YML079W
so part of: sequence
location: <110247..>110852
location: region:110247-110852:1
so has part: feature:110247-110852:1:exon
subclass of: SO_0000010

854896
type: Gene
SIO_000068: ncbigene

position:110247:1
position: 110247
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110852:1
position: 110852
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110247-110852:1:exon

YML079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CFF1
locus tag: YML079W
product: Cff1p
transcript id: NM_001182438.1
SIO_010081: YML079W
subclass of: SO_0000673
so part of: YML079W
location: <110247..>110852
location: region:110247-110852:1
so has part: feature:110247-110852:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:110247-110852:1:exon

YML079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CFF1
locus tag: YML079W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Protein required for production of 4-hydroxy-5-methylfuran-3(2H)-one (MHF); cupin superfamily protein; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to nucleus and cytoplasm
codon start: 1
product: Cff1p
translation: MSANVQEAANAAIEPASFVKVPMPEPPSSLQQLINDWQLIKHREGGYFKETDRSPYTMEVEKPVNGGSGNTEMVTRNQSTLIYYLLTPDSPIGKFHKNINRIIHILQRGKGQYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFDNGFLISEVVVPGFDFEDHTFLKGEDELKHLVGPEKAAELAFLA
SIO_010081: YML079W
subclass of: SO_0000673
so part of: YML079W
location: 110247..110852
location: region:110247-110852:1
so has part: feature:110247-110852:1:exon

NP_013632.1
type: Protein
SIO_000068: ncbiprotein

S000004544
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110247-110852:1:exon

YML078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP3
gene: CPR3
locus tag: YML078W
gene synonym: CYP3
so part of: sequence
location: <111002..>111550
location: region:111002-111550:1
so has part: feature:111002-111550:1:exon
subclass of: SO_0000010

854897
type: Gene
SIO_000068: ncbigene

position:111002:1
position: 111002
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:111550:1
position: 111550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111002-111550:1:exon

YML078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP3
gene: CPR3
locus tag: YML078W
gene synonym: CYP3
product: peptidylprolyl isomerase CPR3
transcript id: NM_001182437.1
SIO_010081: YML078W
subclass of: SO_0000673
so part of: YML078W
location: <111002..>111550
location: region:111002-111550:1
so has part: feature:111002-111550:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111002-111550:1:exon

YML078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP3
gene: CPR3
locus tag: YML078W
gene synonym: CYP3
EC number: 5.2.1.8
experiment: EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:7603990]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7603990|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7603990]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17881727]
note: Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
codon start: 1
product: peptidylprolyl isomerase CPR3
translation: MFKRSIIQQSRLFSNSASRLGKKVFFDPAVNGTKIGRIEFELYDNVVPKTAENFRALCTGEKGWGYKGVPFHRIIPDFMIQGGDTDLTNGFGGKSIYGSKFADENFVKKHDKAGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVTKGMDIVKAIESYGTASGKPRAEIVIEEAGEL
SIO_010081: YML078W
subclass of: SO_0000673
so part of: YML078W
location: 111002..111550
location: region:111002-111550:1
so has part: feature:111002-111550:1:exon

NP_013633.1
type: Protein
SIO_000068: ncbiprotein

S000004543
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111002-111550:1:exon

YML077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BET5
locus tag: YML077W
so part of: sequence
location: <111865..>112344
location: region:111865-112344:1
so has part: feature:111865-112344:1:exon
subclass of: SO_0000010

854898
type: Gene
SIO_000068: ncbigene

position:111865:1
position: 111865
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:112344:1
position: 112344
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111865-112344:1:exon

YML077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BET5
locus tag: YML077W
product: TRAPP subunit BET5
transcript id: NM_001182436.1
SIO_010081: YML077W
subclass of: SO_0000673
so part of: YML077W
location: <111865..>112344
location: region:111865-112344:1
so has part: feature:111865-112344:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111865-112344:1:exon

YML077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BET5
locus tag: YML077W
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]
experiment: EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9611195]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9611195]
experiment: EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17287728]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471|PMID:9611195]
note: Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant
codon start: 1
product: TRAPP subunit BET5
translation: MGIYSFWIFDRHCNCIFDREWTLASNSASGTINSKQNEEDAKLLYGMIFSLRSITQKLSKGSVKNDIRSISTGKYRVHTYCTASGLWFVLLSDFKQQSYTQVLQYIYSHIYVKYVSNNLLSPYDFAENENEMRGQGTRKITNRNFISVLESFLAPMVNQ
SIO_010081: YML077W
subclass of: SO_0000673
so part of: YML077W
location: 111865..112344
location: region:111865-112344:1
so has part: feature:111865-112344:1:exon

NP_013634.1
type: Protein
SIO_000068: ncbiprotein

S000004542
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111865-112344:1:exon

YML076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WAR1
locus tag: YML076C
so part of: sequence
location: complement(<112513..>115347)
location: region:112513-115347:-1
so has part: feature:112513-115347:-1:exon
subclass of: SO_0000010

854899
type: Gene
SIO_000068: ncbigene

position:112513:-1
position: 112513
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:115347:-1
position: 115347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112513-115347:-1:exon

YML076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WAR1
locus tag: YML076C
product: War1p
transcript id: NM_001182435.1
SIO_010081: YML076C
subclass of: SO_0000673
so part of: YML076C
location: complement(<112513..>115347)
location: region:112513-115347:-1
so has part: feature:112513-115347:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:112513-115347:-1:exon

YML076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WAR1
locus tag: YML076C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12588995]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:12588995]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12588995]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:12588995]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12588995]
note: Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
codon start: 1
product: War1p
translation: MDTQIAITGVAVGKEINNDNSKTDQKVSLPKADVPCIDKATQTIIEGCSKDDPRLSYPTKLETTEKGKTKRNSFACVCCHSLKQKCEPSDVNDIYRKPCRRCLKHKKLCKFDLSKRTRKRKPRSRSPTPFESPMVNVSTKSKGPTDSEESSLKDGTSYLASFPSDPNAKQFPNSRTVLPGLQQSLSDLWSTLSQPPSYGAREAETTSTGEITTNNHTKSNGSVPTNPAVLASNDEHTNISDAPVIYSTYNSPVPISSAPTSINSEALFKHRPKIVGDEETQNVKVKRQKKSYSRHMTRSFRKQLQSLIISQKGKIRDISMKLDTWSKQWNDLVEKSMFLPTIADPVSVGIISHEEATLRLHLYKTEISYLSKLPFIKVEENVSVDELRKKKPILFSVIMSCVSIVLTPKQTTRGTIMKLDSFVLNLITNQIFKANNKSIEIIESLSTLCLWYNFFEWSSKTRYHIFNYICCCLTRDLGPTYVNRSFGMFSDEDPKRFKSPLELYSNGASLTLLVYISALNISIFLRQSIQARWSHVTEKACEDLVKETKKSRHYDNDKLLLDSADDPILVQFAKMNHVLENIHTHLHERDLNDDEFDDPIFTKKYLNKLMEKYHKQLQEIFTKLDRNRPRVIAFYYSVEAYLYQYKLAVFIGEMSHTINEKVELPREIMDDFVKCYHCCKSALEEFSKLEPILITSLPLFHTSRIIYTVGMLLLKLRYSVVAIPSFHDLMPLTDDAIALVIGVNNLLEKTSELYPFNNSLYKFRYVIALFCQTYANKVIDVADRYNAEREKLKEKQVIDEVSNGHDGTKPINAYVTESQKMPTEEDPIIDNNTNQNITAVPDEMLPVYSRVRDDTAAMNLNINSTSYMNESPHEHRESMTGTTLLPPPFISNDVTNSADSTNIKPSPSSSVDNLNDYLTDINSLAWGVNSLNDEFWTDLFMNDI
SIO_010081: YML076C
subclass of: SO_0000673
so part of: YML076C
location: complement(112513..115347)
location: region:112513-115347:-1
so has part: feature:112513-115347:-1:exon

NP_013635.1
type: Protein
SIO_000068: ncbiprotein

S000004541
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:112513-115347:-1:exon

YML075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HMG1
locus tag: YML075C
so part of: sequence
location: complement(<115734..>118898)
location: region:115734-118898:-1
so has part: feature:115734-118898:-1:exon
subclass of: SO_0000010

854900
type: Gene
SIO_000068: ncbigene

position:115734:-1
position: 115734
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:118898:-1
position: 118898
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:115734-118898:-1:exon

YML075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HMG1
locus tag: YML075C
product: hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
transcript id: NM_001182434.1
SIO_010081: YML075C
subclass of: SO_0000673
so part of: YML075C
location: complement(<115734..>118898)
location: region:115734-118898:-1
so has part: feature:115734-118898:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:115734-118898:-1:exon

YML075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HMG1
locus tag: YML075C
EC number: 1.1.1.34
experiment: EXISTENCE:curator inference:GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway [PMID:3526336]
experiment: EXISTENCE:direct assay:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:3526336]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:8744950]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8744950]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8744950]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:3526336]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922|PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:2828155]
experiment: EXISTENCE:mutant phenotype:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:2828155]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9292983]
note: HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant
codon start: 1
product: hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
translation: MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVFETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPHHYYLLNLNFNSPNETDSIPELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYDVFSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQCILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEIVFESVSEEGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVFINFYNFGANWVNDAFNSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVLLLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKTEVTKKSFTAPVQKASTPVLTNKTVISGSKVKSLSSAQSSSSGPSSSSEEDDSRDIESLDKKIRPLEELEALLSSGNTKQLKNKEVAALVIHGKLPLYALEKKLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSHMTHNRKPAEPTKPNNLDATDINRLKDGSVTCIKS
SIO_010081: YML075C
subclass of: SO_0000673
so part of: YML075C
location: complement(115734..118898)
location: region:115734-118898:-1
so has part: feature:115734-118898:-1:exon

NP_013636.1
type: Protein
SIO_000068: ncbiprotein

S000004540
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:115734-118898:-1:exon

YML074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NPI46
gene: FPR3
locus tag: YML074C
gene synonym: NPI46
so part of: sequence
location: complement(<120089..>121324)
location: region:120089-121324:-1
so has part: feature:120089-121324:-1:exon
subclass of: SO_0000010

854901
type: Gene
SIO_000068: ncbigene

position:120089:-1
position: 120089
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121324:-1
position: 121324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:120089-121324:-1:exon

YML074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NPI46
gene: FPR3
locus tag: YML074C
gene synonym: NPI46
product: peptidylprolyl isomerase FPR3
transcript id: NM_001182433.1
SIO_010081: YML074C
subclass of: SO_0000673
so part of: YML074C
location: complement(<120089..>121324)
location: region:120089-121324:-1
so has part: feature:120089-121324:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:120089-121324:-1:exon

YML074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NPI46
gene: FPR3
locus tag: YML074C
gene synonym: NPI46
EC number: 5.2.1.8
experiment: EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:7525596|PMID:7925954|PMID:8051210]
experiment: EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:7925954]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26359986]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:7525596|PMID:8051210]
experiment: EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:24297734]
experiment: EXISTENCE:direct assay:GO:0051598 meiotic recombination checkpoint signaling [PMID:16179256]
experiment: EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:16179256]
note: Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication
codon start: 1
product: peptidylprolyl isomerase FPR3
translation: MSDLLPLATYSLNVEPYTPVPAIDVTMPITVRITMAALNPEAIDEENKPSTLRIIKRNPDFEDDDFLGGDFDEDEIDEESSEEEEEEKTQKKKKSKGKKAESESEDDEEDDDEDDEFQESVLLTLSPEAQYQQSLDLTITPEEEVQFIVTGSYAISLSGNYVKHPFDTPMGVEGEDEDEDADIYDSEDYDLTPDEDEIIGDDMDDLDDEEEEEVRIEEVQEEDEEDNDGEEEQEEEEEEEQKEEVKPEPKKSKKEKKRKHEEKEEEKKAKKVKKVEFKKDLEEGPTKPKSKKEQDKHKPKSKVLEGGIVIEDRTIGDGPQAKRGARVGMRYIGKLKNGKVFDKNTSGKPFAFKLGRGEVIKGWDIGVAGMSVGGERRIIIPAPYAYGKQALPGIPANSELTFDVKLVSMKN
SIO_010081: YML074C
subclass of: SO_0000673
so part of: YML074C
location: complement(120089..121324)
location: region:120089-121324:-1
so has part: feature:120089-121324:-1:exon

NP_013637.1
type: Protein
SIO_000068: ncbiprotein

S000004539
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:120089-121324:-1:exon

YML073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YL16A
gene: RPL6A
locus tag: YML073C
gene synonym: YL16A
so part of: sequence
location: complement(<123227..>124172)
location: region:123227-124172:-1
so has part: feature:123227-124172:-1:exon
subclass of: SO_0000010

854902
type: Gene
SIO_000068: ncbigene

position:123227:-1
position: 123227
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:124172:-1
position: 124172
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123227-124172:-1:exon

YML073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YL16A
gene: RPL6A
locus tag: YML073C
gene synonym: YL16A
product: ribosomal 60S subunit protein L6A
transcript id: NM_001182432.1
SIO_010081: YML073C
subclass of: SO_0000673
so part of: YML073C
location: complement(join(<123227..123742,124158..>124172))
location: region:123227-124172:-1
so has part: feature:124158-124172:-1:exon
so has part: feature:123227-123742:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124158-124172:-1:exon

position:124158:-1
position: 124158
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:123227-123742:-1:exon

position:123742:-1
position: 123742
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YL16A
gene: RPL6A
locus tag: YML073C
gene synonym: YL16A
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:3282992]
note: Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L6A
translation: MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANLFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDKPHMLKF
SIO_010081: YML073C
subclass of: SO_0000673
so part of: YML073C
location: complement(join(123227..123742,124158..124172))
location: region:123227-124172:-1
so has part: feature:124158-124172:-1:exon
so has part: feature:123227-123742:-1:exon

NP_013638.1
type: Protein
SIO_000068: ncbiprotein

S000004538
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124158-124172:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:123227-123742:-1:exon

YML072C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCB3
locus tag: YML072C
so part of: sequence
location: complement(<124730..>129367)
location: region:124730-129367:-1
so has part: feature:124730-129367:-1:exon
subclass of: SO_0000010

854903
type: Gene
SIO_000068: ncbigene

position:124730:-1
position: 124730
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:129367:-1
position: 129367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:124730-129367:-1:exon

YML072C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCB3
locus tag: YML072C
product: Tcb3p
transcript id: NM_001182431.1
SIO_010081: YML072C
subclass of: SO_0000673
so part of: YML072C
location: complement(<124730..>129367)
location: region:124730-129367:-1
so has part: feature:124730-129367:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124730-129367:-1:exon

YML072C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCB3
locus tag: YML072C
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:33933446]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:15049706]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:23237950|PMID:22250200]
experiment: EXISTENCE:direct assay:GO:0120010 intermembrane phospholipid transfer [PMID:33933446]
experiment: EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]
experiment: EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]
experiment: EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]
experiment: EXISTENCE:mutant phenotype:GO:0120010 intermembrane phospholipid transfer [PMID:33933446]
note: Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane; regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; involved in intermembrane phospholipid transfer; also localizes to the mitochondria in a phosphorylated state and is enriched in bud membranes; mRNA is targeted to the bud tip
codon start: 1
product: Tcb3p
translation: MTGIKAQVHPPPDSTLFHEEEKKKVGGNLPQKVINQQERGSDHAPSGHHQYHQLINHDANDTKTSNSVSDVSKGQKTADSNPEGKKQSSKDIFVASSAQKTNQLPGPNPQGSIGAVPLEGLRPKEFRSAPSRKPNKFDTSITKPGVLDDLGKLDEKDIKEKFHLDSDDKLFPWQNVGEFHASGKGSPNTKMSRVIKAYILENFYNDWYCNIATVLGTCFFSWLFAYIGFSWWSMIFIFLGTATVYNAEYTRFNRNIRDDLKRVTVEETLSDRVESTTWLNSFLSKFWVIYMPVLSQQVKDNVNPQLAGVAPGYGIDALAIDEFTLGSKAPTIKGIKSYTKTGKNTVEMDWSFAFTPSDVSDMTATEAREKINPKISLGVTLGKSFVSKTMPILVEDINVAGKMRIKVEFGKAFPNIKIVSLQLLEPPLIDFALKPIGGDTLGLDVMSFLPGLKSFVKNIINSNIGPMLFPPNHLDINVEDIMAAQSKEAIGVLAVTIASADSLKGSDFITNTVDPYIVMTTEDAVPGTDEEVRTSIKSNVKNPRWNETKYLLLNTLEQKLNLKCFDFNDVRKDTVIGDLQLDLADLLQNPVLDNQTAELRSGTKSKGILHYSLHWFPVKEDKSEEKAVERAEAKAKGKKEDENEDTTEKEEDENEESSQTDVGIAKITLQKVKYLDTTSSMTGSLSPCAELFIDGQKVKSYRTLRRINEPSWNETIEVLVPSKSNSKFVLKIFDDRMNGKALICEYSSSLDDIMTTLDTAQEFVKGSPQGDIYLDVSWKSIEMTGAFAAANSVSEPIGCIKLDVKDAIIKGDLSGVGDVDPYYTVSLNRRVLYKSIYHSDTDHPIFDNSTYVPIFSPNQILTLEFHDYQKIGKDRFIGSVQIPTSNVFKKDPKSGKYVGNNGKEEISKLKLKDHEHKVTESIVNVSTTFIPINLVYSPEELVNVEKLEKELKEKKKKFEATQEENEQEMEKNPKEWEVAEIEDPFDSDEKKINRKAKLSLNELIKQKSGILSMQILEGTLSPSSAYLEILADDISYPVFICMKPSQGKLNSEMANIFIRDLNYSKLHFRVSKKHIAKDSDDVISETSYSTLKLLKQAYEEPMWLNFNGSKMKVRFLYTPTSVKLPSSESVEDTGYLNIKLISGHGLKSADRNGYSDPFVHIFVNDKKVFKSNIKKKTLDPVWNEDAKIPILSRSKNQVIFNVLDWDRAGDNDDLGQASLDVSSLEVGKTYNWNLNLNTQGSIKLQGSFNPEYIKPSFDIVKGGITDKPMKIASGAAHATVGIAGTGIGAATGVATGGLKKGGHLLKSLGGNPMKRSKSSNGNESNGAKKSSEKKSFDRRSPSNLNSTSVTPRASLDYDPSVPNTSYAPVQSASPVVKPTDNTSSSSNKKDTPSSNSRGHSRASSFARTLAPHGTYNGFITVVAAENVAKHVQIKISLTQGGRLKHIYKTKSQKANNDGVAVFDEECSFKASPEANLVLGAISHQRLSRDKDLGIAQINLGDPQIQQDGQISVKLGDGHLIVKINYGKDKNGQVPPVPEVPQEYTQ
SIO_010081: YML072C
subclass of: SO_0000673
so part of: YML072C
location: complement(124730..129367)
location: region:124730-129367:-1
so has part: feature:124730-129367:-1:exon

NP_013639.1
type: Protein
SIO_000068: ncbiprotein

S000004537
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124730-129367:-1:exon

YML071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DOR1
gene: COG8
locus tag: YML071C
gene synonym: DOR1
so part of: sequence
location: complement(<129749..>131572)
location: region:129749-131572:-1
so has part: feature:129749-131572:-1:exon
subclass of: SO_0000010

854904
type: Gene
SIO_000068: ncbigene

position:129749:-1
position: 129749
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131572:-1
position: 131572
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129749-131572:-1:exon

YML071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DOR1
gene: COG8
locus tag: YML071C
gene synonym: DOR1
product: Golgi transport complex subunit COG8
transcript id: NM_001182430.1
SIO_010081: YML071C
subclass of: SO_0000673
so part of: YML071C
location: complement(<129749..>131572)
location: region:129749-131572:-1
so has part: feature:129749-131572:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129749-131572:-1:exon

YML071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DOR1
gene: COG8
locus tag: YML071C
gene synonym: DOR1
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
note: Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG8
translation: MELILNSLISDDLTEEQKRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDNTSQIIGNILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFLEDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSITDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLLSTNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYPLDVESSNESLIEMMVKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGTNEEKEIEEKEKETKKEEYQKQDSVANNEEDVTENKSIEDVQEEVQGKVEGEDDGAERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEEINKVEVTPEEPSKSIDNKAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRGLNSIKLSDSVCLQLVYCSFRLCDLNRNYHHLFLKKINDTSLFTTEQLARAIDKRAELASKYIYS
SIO_010081: YML071C
subclass of: SO_0000673
so part of: YML071C
location: complement(129749..131572)
location: region:129749-131572:-1
so has part: feature:129749-131572:-1:exon

NP_013640.1
type: Protein
SIO_000068: ncbiprotein

S000004536
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129749-131572:-1:exon

YNCM0004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0004C
so part of: sequence
location: complement(131825..131896)
location: region:131825-131896:-1
so has part: feature:131825-131896:-1:exon
subclass of: SO_0000663

854905
type: Gene
SIO_000068: ncbigene

position:131825:-1
position: 131825
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:131896:-1
position: 131896
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131825-131896:-1:exon

YNCM0004C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0004C
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCM0004C
subclass of: SO_0000673
so part of: YNCM0004C
location: complement(131825..131896)
location: region:131825-131896:-1
so has part: feature:131825-131896:-1:exon

S000006718
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131825-131896:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(131989..132321)
location: region:131989-132321:-1
so has part: feature:131989-132321:-1:region

S000007101
type: SGD
SIO_000068: sgd

position:131989:-1
position: 131989
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:132321:-1
position: 132321
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131989-132321:-1:region

YML070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DAK1
locus tag: YML070W
so part of: sequence
location: <133475..>135229
location: region:133475-135229:1
so has part: feature:133475-135229:1:exon
subclass of: SO_0000010

854932
type: Gene
SIO_000068: ncbigene

position:133475:1
position: 133475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135229:1
position: 135229
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133475-135229:1:exon

YML070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DAK1
locus tag: YML070W
product: dihydroxyacetone kinase
transcript id: NM_001182429.1
SIO_010081: YML070W
subclass of: SO_0000673
so part of: YML070W
location: <133475..>135229
location: region:133475-135229:1
so has part: feature:133475-135229:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:133475-135229:1:exon

YML070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DAK1
locus tag: YML070W
EC number: 2.7.1.28
EC number: 2.7.1.29
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004371 glycerone kinase activity [PMID:12401799]
experiment: EXISTENCE:genetic interaction:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]
experiment: EXISTENCE:mutant phenotype:GO:0004371 glycerone kinase activity [PMID:12401799]
experiment: EXISTENCE:mutant phenotype:GO:0097237 cellular response to toxic substance [PMID:12401799]
note: Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
codon start: 1
product: dihydroxyacetone kinase
translation: MSAKSFEVTDPVNSSLKGFALANPSITLVPEEKILFRKTDSDKIALISGGGSGHEPTHAGFIGKGMLSGAVVGEIFASPSTKQILNAIRLVNENASGVLLIVKNYTGDVLHFGLSAERARALGINCRVAVIGDDVAVGREKGGMVGRRALAGTVLVHKIVGAFAEEYSSKYGLDGTAKVAKIINDNLVTIGSSLDHCKVPGRKFESELNEKQMELGMGIHNEPGVKVLDPIPSTEDLISKYMLPKLLDPNDKDRAFVKFDEDDEVVLLVNNLGGVSNFVISSITSKTTDFLKENYNITPVQTIAGTLMTSFNGNGFSITLLNATKATKALQSDFEEIKSVLDLLNAFTNAPGWPIADFEKTSAPSVNDDLLHNEVTAKAVGTYDFDKFAEWMKSGAEQVIKSEPHITELDNQVGDGDCGYTLVAGVKGITENLDKLSKDSLSQAVAQISDFIEGSMGGTSGGLYSILLSGFSHGLIQVCKSKDEPVTKEIVAKSLGIALDTLYKYTKARKGSSTMIDALEPFVKEFTASKDFNKAVKAAEEGAKSTATFEAKFGRASYVGDSSQVEDPGAVGLCEFLKGVQSAL
SIO_010081: YML070W
subclass of: SO_0000673
so part of: YML070W
location: 133475..135229
location: region:133475-135229:1
so has part: feature:133475-135229:1:exon

NP_013641.1
type: Protein
SIO_000068: ncbiprotein

S000004535
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:133475-135229:1:exon

YML069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POB3
locus tag: YML069W
so part of: sequence
location: <135500..>137158
location: region:135500-137158:1
so has part: feature:135500-137158:1:exon
subclass of: SO_0000010

854933
type: Gene
SIO_000068: ncbigene

position:135500:1
position: 135500
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:137158:1
position: 137158
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135500-137158:1:exon

YML069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POB3
locus tag: YML069W
product: FACT complex subunit POB3
transcript id: NM_001182428.1
SIO_010081: YML069W
subclass of: SO_0000673
so part of: YML069W
location: <135500..>137158
location: region:135500-137158:1
so has part: feature:135500-137158:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:135500-137158:1:exon

YML069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POB3
locus tag: YML069W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10413469]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10413469]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:15082784|PMID:19683499]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837]
experiment: EXISTENCE:direct assay:GO:0035101 FACT complex [PMID:9705338]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18089575]
experiment: EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15987999]
experiment: EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:10924459]
experiment: EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:10924459]
experiment: EXISTENCE:physical interaction:GO:0006261 DNA-templated DNA replication [PMID:9199353]
note: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
codon start: 1
product: FACT complex subunit POB3
translation: MSTDFDRIYLNQSKFSGRFRIADSGLGWKISTSGGSAANQARKPFLLPATELSTVQWSRGCRGYDLKINTKNQGVIQLDGFSQDDYNLIKNDFHRRFNIQVEQREHSLRGWNWGKTDLARNEMVFALNGKPTFEIPYARINNTNLTSKNEVGIEFNIQDEEYQPAGDELVEMRFYIPGVIQTNVDENMTKKEESSNEVVPKKEDGAEGEDVQMAVEEKSMAEAFYEELKEKADIGEVAGDAIVSFQDVFFTTPRGRYDIDIYKNSIRLRGKTYEYKLQHRQIQRIVSLPKADDIHHLLVLAIEPPLRQGQTTYPFLVLQFQKDEETEVQLNLEDEDYEENYKDKLKKQYDAKTHIVLSHVLKGLTDRRVIVPGEYKSKYDQCAVSCSFKANEGYLYPLDNAFFFLTKPTLYIPFSDVSMVNISRAGQTSTSSRTFDLEVVLRSNRGSTTFANISKEEQQLLEQFLKSKNLRVKNEDREVQERLQTALGSDSDEEDINMGSAGEDDESVDEDFQVSSDNDADEVAEEFDSDAALSDAEGGSDEERPSKKPKVE
SIO_010081: YML069W
subclass of: SO_0000673
so part of: YML069W
location: 135500..137158
location: region:135500-137158:1
so has part: feature:135500-137158:1:exon

NP_013642.1
type: Protein
SIO_000068: ncbiprotein

S000004534
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:135500-137158:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1307; Autonomously Replicating Sequence
so part of: sequence
location: 137300..137548
location: region:137300-137548:1
so has part: feature:137300-137548:1:region

S000118367
type: SGD
SIO_000068: sgd

position:137300:1
position: 137300
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:137548:1
position: 137548
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137300-137548:1:region

YML068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITT1
locus tag: YML068W
so part of: sequence
location: <137550..>138944
location: region:137550-138944:1
so has part: feature:137550-138944:1:exon
subclass of: SO_0000010

854934
type: Gene
SIO_000068: ncbigene

position:137550:1
position: 137550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:138944:1
position: 138944
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137550-138944:1:exon

YML068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ITT1
locus tag: YML068W
product: RBR-type E3 ubiquitin transferase
transcript id: NM_001182427.1
SIO_010081: YML068W
subclass of: SO_0000673
so part of: YML068W
location: <137550..>138944
location: region:137550-138944:1
so has part: feature:137550-138944:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:137550-138944:1:exon

YML068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ITT1
locus tag: YML068W
EC number: 2.3.2.31
experiment: EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:11570975]
note: Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
codon start: 1
product: RBR-type E3 ubiquitin transferase
translation: MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCHFVFCFDCLHAWHGYNNKCGKKVSLSTDIIEEYLDDTVTSYERKRKLEAKYGRRVLELEVNDYLAEKMLDLAIKKEGSNLQRCPKCKVVVERSEGCNKMKCEVCGTLFCFICGVLLYPEDPYEHFREAYSGCYGRLFEGMPGTET
SIO_010081: YML068W
subclass of: SO_0000673
so part of: YML068W
location: 137550..138944
location: region:137550-138944:1
so has part: feature:137550-138944:1:exon

NP_013643.1
type: Protein
SIO_000068: ncbiprotein

S000004533
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:137550-138944:1:exon

YML067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERV41
locus tag: YML067C
so part of: sequence
location: complement(<139063..>140214)
location: region:139063-140214:-1
so has part: feature:139063-140214:-1:exon
subclass of: SO_0000010

854935
type: Gene
SIO_000068: ncbigene

position:139063:-1
position: 139063
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:140214:-1
position: 140214
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139063-140214:-1:exon

YML067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERV41
locus tag: YML067C
product: Erv41p
transcript id: NM_001182426.1
SIO_010081: YML067C
subclass of: SO_0000673
so part of: YML067C
location: complement(join(<139063..140090,140184..>140214))
location: region:139063-140214:-1
so has part: feature:140184-140214:-1:exon
so has part: feature:139063-140090:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140184-140214:-1:exon

position:140184:-1
position: 140184
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:139063-140090:-1:exon

position:140090:-1
position: 140090
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERV41
locus tag: YML067C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11157978]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11157978]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]
note: Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
codon start: 1
product: Erv41p
translation: MAGLKTFDAFPKTEEQYKKKSTKGGLTSLLTYLFLLFIAWTEFGEYFGGYIDQQYVVDSQVRDTVQINMDIYVNTKCDWLQINVRDQTMDRKLVLEELQLEEMPFFIPYDTKVNDINEIITPELDEILGEAIPAEFREKLDTRSFFDESDPNKAHLPEFNGCHVFGSIPVNRVSGELQITAKSLGYVASRKAPLEELKFNHVINEFSFGDFYPYIDNPLDNTAQFNQDEPLTTYVYYTSVVPTLFKKLGAEVDTNQYSVNDYRYLYKDVAAKGDKMPGIFFKYNFEPLSIVVSDVRLSFIQFLVRLVAICSFLVYCASWIFTLLDMALITIMGPKWSLRYQPDDKTKGILDR
SIO_010081: YML067C
subclass of: SO_0000673
so part of: YML067C
location: complement(join(139063..140090,140184..140214))
location: region:139063-140214:-1
so has part: feature:140184-140214:-1:exon
so has part: feature:139063-140090:-1:exon

NP_013644.1
type: Protein
SIO_000068: ncbiprotein

S000004532
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140184-140214:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:139063-140090:-1:exon

YML066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMA2
locus tag: YML066C
so part of: sequence
location: complement(<140424..>141533)
location: region:140424-141533:-1
so has part: feature:140424-141533:-1:exon
subclass of: SO_0000010

854936
type: Gene
SIO_000068: ncbigene

position:140424:-1
position: 140424
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141533:-1
position: 141533
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140424-141533:-1:exon

YML066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMA2
locus tag: YML066C
product: Sma2p
transcript id: NM_001182425.1
SIO_010081: YML066C
subclass of: SO_0000673
so part of: YML066C
location: complement(<140424..>141533)
location: region:140424-141533:-1
so has part: feature:140424-141533:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140424-141533:-1:exon

YML066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMA2
locus tag: YML066C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:17298976|PMID:18756268|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17298976]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]
note: Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
codon start: 1
product: Sma2p
translation: MLFPKRLIVWGVLLILSLSQFVLYLPATTCTNSKGLRLCAPQFTITVIGGSSTANEFIASVREFLRLISYLTIDMGWSNEFTDPSVYEDENLVDTFQPDKVFELNYFGFCKRSNKSKVYCTSNENYGMDVLEVLVRDVGIQLGNISTTRSNETKKFGDSLVLTYRLALTSIRDFLKHDKHTGNALSKALIGSPDPNVKGVSPTKNYLKGVNLAFILMMFNGMVFYFAVLEIIVGFLSICVVSAFGGALSVGKRHRLFPMLLKSSSSILVVIATLTILCNIVYLIALKTLEPEEVTDVGSDNAAVHTTGWELLKVNVGSGFIMGLARYAIQWVLLVLAFLAANHYKAKPKKSDKYTEDTSNSPSPDLMEK
SIO_010081: YML066C
subclass of: SO_0000673
so part of: YML066C
location: complement(140424..141533)
location: region:140424-141533:-1
so has part: feature:140424-141533:-1:exon

NP_013645.1
type: Protein
SIO_000068: ncbiprotein

S000004531
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140424-141533:-1:exon

YML065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ORC1
locus tag: YML065W
so part of: sequence
location: <142210..>144954
location: region:142210-144954:1
so has part: feature:142210-144954:1:exon
subclass of: SO_0000010

854937
type: Gene
SIO_000068: ncbigene

position:142210:1
position: 142210
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:144954:1
position: 144954
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:142210-144954:1:exon

YML065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ORC1
locus tag: YML065W
product: origin recognition complex subunit 1
transcript id: NM_001182424.1
SIO_010081: YML065W
subclass of: SO_0000673
so part of: YML065W
location: <142210..>144954
location: region:142210-144954:1
so has part: feature:142210-144954:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:142210-144954:1:exon

YML065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ORC1
locus tag: YML065W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11168584]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:17825064]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11168584]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051|PMID:16581798]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:31263106]
experiment: EXISTENCE:direct assay:GO:0043007 maintenance of rDNA [PMID:31263106]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16581798]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9038340]
experiment: EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:9335335]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:9038340]
note: Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication
codon start: 1
product: origin recognition complex subunit 1
translation: MAKTLKDLQGWEIITTDEQGNIIDGGQKRLRRRGAKTEHYLKRSSDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQEYLKDLTLPSKKKEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKPKDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANFQDYLPARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTGYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRLRMSADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENEEQIYDDEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL
SIO_010081: YML065W
subclass of: SO_0000673
so part of: YML065W
location: 142210..144954
location: region:142210-144954:1
so has part: feature:142210-144954:1:exon

NP_013646.1
type: Protein
SIO_000068: ncbiprotein

S000004530
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:142210-144954:1:exon

YML064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TEM1
locus tag: YML064C
so part of: sequence
location: complement(<145139..>145876)
location: region:145139-145876:-1
so has part: feature:145139-145876:-1:exon
subclass of: SO_0000010

854938
type: Gene
SIO_000068: ncbigene

position:145139:-1
position: 145139
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145876:-1
position: 145876
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145139-145876:-1:exon

YML064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TEM1
locus tag: YML064C
product: Ras family GTPase TEM1
transcript id: NM_001182423.1
SIO_010081: YML064C
subclass of: SO_0000673
so part of: YML064C
location: complement(<145139..>145876)
location: region:145139-145876:-1
so has part: feature:145139-145876:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145139-145876:-1:exon

YML064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TEM1
locus tag: YML064C
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:12048186|PMID:25658911]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:19154724]
experiment: EXISTENCE:direct assay:GO:0023056 positive regulation of signaling [PMID:32074005]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:21321099]
experiment: EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:21937712]
experiment: EXISTENCE:mutant phenotype:GO:1902542 regulation of protein localization to mitotic spindle pole body [PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:10219244]
note: GTPase involved in initiation of Mitotic Exit Network (MEN); GTP-binding protein of the Ras superfamily; accumulates at daughter spindle pole body and activates MEN kinase cascade; controls actomyosin and septin dynamics during cytokinesis
codon start: 1
product: Ras family GTPase TEM1
translation: MATPSTGANNSIPAVRNQVEVQVGLVGDAQVGKTSLMVKYVQNIYDKEYTQTLGVNFLKRKVSIRSTDIIFSIMDLGGQREFINMLPIATVGSSVIIFLFDLTRPETLSSIKEWYRQAYGLNDSAIPILVGTKYDLLIDLDPEYQEQISRTSMKYAQVMNAPLIFCSTAKSINIQKIFKIALAKIFNLTLTIPEINEIGDPLLIYKHLGGQQHRHHNKSQDRKSHNIRKPSSSPSSKAPSPGVNT
SIO_010081: YML064C
subclass of: SO_0000673
so part of: YML064C
location: complement(145139..145876)
location: region:145139-145876:-1
so has part: feature:145139-145876:-1:exon

NP_013647.1
type: Protein
SIO_000068: ncbiprotein

S000004529
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145139-145876:-1:exon

YML063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PLC2
alternative label: RP10B
gene: RPS1B
locus tag: YML063W
gene synonym: PLC2; RP10B
so part of: sequence
location: <146482..>147249
location: region:146482-147249:1
so has part: feature:146482-147249:1:exon
subclass of: SO_0000010

854939
type: Gene
SIO_000068: ncbigene

position:146482:1
position: 146482
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147249:1
position: 147249
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146482-147249:1:exon

YML063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PLC2
alternative label: RP10B
gene: RPS1B
locus tag: YML063W
gene synonym: PLC2; RP10B
product: ribosomal 40S subunit protein S1B
transcript id: NM_001182422.1
SIO_010081: YML063W
subclass of: SO_0000673
so part of: YML063W
location: <146482..>147249
location: region:146482-147249:1
so has part: feature:146482-147249:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:146482-147249:1:exon

YML063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PLC2
alternative label: RP10B
gene: RPS1B
locus tag: YML063W
gene synonym: PLC2; RP10B
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
note: Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S1B
translation: MAVGKNKRLSRGKKGLKKKVVDPFTRKEWFDIKAPSTFENRNVGKTLVNKSTGLKNASDALKGRVVEVCLADLQGSEDHSFRKVKLRVDEVQGKNLLTNFHGMDFTTDKLRSMVRKWQTLIEANVTVKTSDDYVLRIFAIAFTRKQANQVKRHSYAQSSHIRAIRKVISEILTREVQNSTLAQLTSKLIPEVINKEIENATKDIFPLQNIHVRKVKLLKQPKFDVGALMALHGEGSGEEKGKKVSGFKDEVLETV
SIO_010081: YML063W
subclass of: SO_0000673
so part of: YML063W
location: 146482..147249
location: region:146482-147249:1
so has part: feature:146482-147249:1:exon

NP_013648.1
type: Protein
SIO_000068: ncbiprotein

S000004528
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:146482-147249:1:exon

YML062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MFT52
gene: MFT1
locus tag: YML062C
gene synonym: MFT52
so part of: sequence
location: complement(<147505..>148683)
location: region:147505-148683:-1
so has part: feature:147505-148683:-1:exon
subclass of: SO_0000010

854940
type: Gene
SIO_000068: ncbigene

position:147505:-1
position: 147505
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148683:-1
position: 148683
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:147505-148683:-1:exon

YML062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MFT52
gene: MFT1
locus tag: YML062C
gene synonym: MFT52
product: Mft1p
transcript id: NM_001182421.1
SIO_010081: YML062C
subclass of: SO_0000673
so part of: YML062C
location: complement(<147505..>148683)
location: region:147505-148683:-1
so has part: feature:147505-148683:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:147505-148683:-1:exon

YML062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MFT52
gene: MFT1
locus tag: YML062C
gene synonym: MFT52
experiment: EXISTENCE:direct assay:GO:0000445 THO complex part of transcription export complex [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]
experiment: EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]
experiment: EXISTENCE:mutant phenotype:GO:0000445 THO complex part of transcription export complex [PMID:11979277]
experiment: EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:12093753]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16908536]
note: Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
codon start: 1
product: Mft1p
translation: MPLSQKQIDQVRTKVHYSEVDTPFNKYLDILGKVTKLTGSIINGTLSNDDSKIEKLTEQNISQLKESAHLRFLDLQSSIDTKKVADENWETCQQETLAKLENLKDKLPDIKSIHSKLLLRIGKLQGLYDSVQVINREVEGLSEGRTSLVVTRAEWEKELGTDLVKFLIEKNYLKLVDPGLKKDSSEERYRIYDDFSKGPKELESINASMKSDIENVRQEVSSYKEKWLRDAEIFGKITSIFKEELLKRDGLLNEAEGDNIDEDYESDEDEERKERFKRQRSMVEVNTIENVDEKEESDHEYDDQEDEENEEEDDMEVDVEDIKEDNEVDGESSQQEDNSRQGNNEETDKETGVIEEPDAVNDAEEADSDHSSRKLGGTTSDFSASSSVEEVK
SIO_010081: YML062C
subclass of: SO_0000673
so part of: YML062C
location: complement(147505..148683)
location: region:147505-148683:-1
so has part: feature:147505-148683:-1:exon

NP_013649.1
type: Protein
SIO_000068: ncbiprotein

S000004527
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:147505-148683:-1:exon

YML061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TST1
gene: PIF1
locus tag: YML061C
gene synonym: TST1
so part of: sequence
location: complement(<148953..>151532)
location: region:148953-151532:-1
so has part: feature:148953-151532:-1:exon
subclass of: SO_0000010

854941
type: Gene
SIO_000068: ncbigene

position:148953:-1
position: 148953
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:151532:-1
position: 151532
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148953-151532:-1:exon

YML061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TST1
gene: PIF1
locus tag: YML061C
gene synonym: TST1
product: DNA helicase PIF1
transcript id: NM_001182420.1
SIO_010081: YML061C
subclass of: SO_0000673
so part of: YML061C
location: complement(<148953..>151532)
location: region:148953-151532:-1
so has part: feature:148953-151532:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148953-151532:-1:exon

YML061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TST1
gene: PIF1
locus tag: YML061C
gene synonym: TST1
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:8253734]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:23596008]
experiment: EXISTENCE:direct assay:GO:0005657 replication fork [PMID:26411679]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:1849081|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:31744872]
experiment: EXISTENCE:direct assay:GO:0010521 telomerase inhibitor activity [PMID:16121131]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:30442759]
experiment: EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:20655619]
experiment: EXISTENCE:direct assay:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16121131]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:30068549]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:26981397]
experiment: EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:23657261]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:genetic interaction:GO:0071932 replication fork reversal [PMID:26411679]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:15907372]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:10926538]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:24025772]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:1849081]
experiment: EXISTENCE:mutant phenotype:GO:0010521 telomerase inhibitor activity [PMID:16121131]
experiment: EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:30107417]
experiment: EXISTENCE:mutant phenotype:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16121131]
experiment: EXISTENCE:mutant phenotype:GO:0044806 G-quadruplex DNA unwinding [PMID:23657261]
experiment: EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:8287473]
experiment: EXISTENCE:mutant phenotype:GO:0098781 ncRNA transcription [PMID:31391265]
note: DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; involved in crossover recombination; works with Hrq1p to maintain telomere length homeostasis; translation from different start sites produces mitochondrial (DNA repair and recombination) and nuclear (catalytic inhibitor of telomerase) forms; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
codon start: 1
product: DNA helicase PIF1
translation: MPKWIRSTLNHIIPRRPFICSFNSFLLLKNVSHAKLSFSMSSRGFRSNNFIQAQLKHPSILSKEDLDLLSDSDDWEEPDCIQLETEKQEKKIITDIHKEDPVDKKPMRDKNVMNFINKDSPLSWNDMFKPSIIQPPQLISENSFDQSSQKKSRSTGFKNPLRPALKKESSFDELQNNSISQERSLEMINENEKKKMQFGEKIAVLTQRPSFTELQNDQDDSNLNPHNGVKVKIPICLSKEQESIIKLAENGHNIFYTGSAGTGKSILLREMIKVLKGIYGRENVAVTASTGLAACNIGGITIHSFAGIGLGKGDADKLYKKVRRSRKHLRRWENIGALVVDEISMLDAELLDKLDFIARKIRKNHQPFGGIQLIFCGDFFQLPPVSKDPNRPTKFAFESKAWKEGVKMTIMLQKVFRQRGDVKFIDMLNRMRLGNIDDETEREFKKLSRPLPDDEIIPAELYSTRMEVERANNSRLSKLPGQVHIFNAIDGGALEDEELKERLLQNFLAPKELHLKVGAQVMMVKNLDATLVNGSLGKVIEFMDPETYFCYEALTNDPSMPPEKLETWAENPSKLKAAMEREQSDGEESAVASRKSSVKEGFAKSDIGEPVSPLDSSVFDFMKRVKTDDEVVLENIKRKEQLMQTIHQNSAGKRRLPLVRFKASDMSTRMVLVEPEDWAIEDENEKPLVSRVQLPLMLAWSLSIHKSQGQTLPKVKVDLRRVFEKGQAYVALSRAVSREGLQVLNFDRTRIKAHQKVIDFYLTLSSAESAYKQLEADEQVKKRKLDYAPGPKYKAKSKSKSNSPAPISATTQSNNGIAAMLQRHSRKRFQLKKESNSNQVHSLVSDEPRGQDTEDHILE
SIO_010081: YML061C
subclass of: SO_0000673
so part of: YML061C
location: complement(148953..151532)
location: region:148953-151532:-1
so has part: feature:148953-151532:-1:exon

NP_013650.1
type: Protein
SIO_000068: ncbiprotein

S000004526
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148953-151532:-1:exon

YML060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OGG1
locus tag: YML060W
so part of: sequence
location: <151871..>153001
location: region:151871-153001:1
so has part: feature:151871-153001:1:exon
subclass of: SO_0000010

854942
type: Gene
SIO_000068: ncbigene

position:151871:1
position: 151871
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:153001:1
position: 153001
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151871-153001:1:exon

YML060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OGG1
locus tag: YML060W
product: 8-oxoguanine glycosylase OGG1
transcript id: NM_001182419.1
SIO_010081: YML060W
subclass of: SO_0000673
so part of: YML060W
location: <151871..>153001
location: region:151871-153001:1
so has part: feature:151871-153001:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:151871-153001:1:exon

YML060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OGG1
locus tag: YML060W
EC number: 4.2.99.18
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11239005]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11239005]
experiment: EXISTENCE:direct assay:GO:0006285 base-excision repair, AP site formation [PMID:8643552]
experiment: EXISTENCE:direct assay:GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity [PMID:8643552]
experiment: EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:19264809]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:11239005]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:19942858]
note: Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
codon start: 1
product: 8-oxoguanine glycosylase OGG1
translation: MSYKFGKLAINKSELCLANVLQAGQSFRWIWDEKLNQYSTTMKIGQQEKYSVVILRQDEENEILEFVAVGDCGNQDALKTHLMKYFRLDVSLKHLFDNVWIPSDKAFAKLSPQGIRILAQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTIDGVAYHSFPTSEELTSRATEAKLRELGFGYRAKYIIETARKLVNDKAEANITSDTTYLQSICKDAQYEDVREHLMSYNGVGPKVADCVCLMGLHMDGIVPVDVHVSRIAKRDYQISANKNHLKELRTKYNALPISRKKINLELDHIRLMLFKKWGSYAGWAQGVLFSKEIGGTSGSTTTGTIKKRKWDMIKETEAIVTKQMKLKVELSDLHIKEAKID
SIO_010081: YML060W
subclass of: SO_0000673
so part of: YML060W
location: 151871..153001
location: region:151871-153001:1
so has part: feature:151871-153001:1:exon

NP_013651.1
type: Protein
SIO_000068: ncbiprotein

S000004525
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:151871-153001:1:exon

YML059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NTE1
locus tag: YML059C
so part of: sequence
location: complement(<153219..>158258)
location: region:153219-158258:-1
so has part: feature:153219-158258:-1:exon
subclass of: SO_0000010

854943
type: Gene
SIO_000068: ncbigene

position:153219:-1
position: 153219
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:158258:-1
position: 158258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153219-158258:-1:exon

YML059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NTE1
locus tag: YML059C
product: lysophospholipase
transcript id: NM_001182418.1
SIO_010081: YML059C
subclass of: SO_0000673
so part of: YML059C
location: complement(<153219..>158258)
location: region:153219-158258:-1
so has part: feature:153219-158258:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153219-158258:-1:exon

YML059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NTE1
locus tag: YML059C
EC number: 3.1.1.5
experiment: EXISTENCE:direct assay:GO:0004622 lysophospholipase activity [PMID:15044461]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15044461|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0034638 phosphatidylcholine catabolic process [PMID:15044461]
experiment: EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:19841481]
note: Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
codon start: 1
product: lysophospholipase
translation: MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLAGLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLHRRNSI
SIO_010081: YML059C
subclass of: SO_0000673
so part of: YML059C
location: complement(153219..158258)
location: region:153219-158258:-1
so has part: feature:153219-158258:-1:exon

NP_013652.1
type: Protein
SIO_000068: ncbiprotein

S000004524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153219-158258:-1:exon

YML058W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HUG1
locus tag: YML058W-A
so part of: sequence
location: <158760..>158966
location: region:158760-158966:1
so has part: feature:158760-158966:1:exon
subclass of: SO_0000010

854944
type: Gene
SIO_000068: ncbigene

position:158760:1
position: 158760
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:158966:1
position: 158966
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:158760-158966:1:exon

YML058W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HUG1
locus tag: YML058W-A
product: Hug1p
transcript id: NM_001184439.1
SIO_010081: YML058W-A
subclass of: SO_0000673
so part of: YML058W-A
location: <158760..>158966
location: region:158760-158966:1
so has part: feature:158760-158966:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:158760-158966:1:exon

YML058W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HUG1
locus tag: YML058W-A
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:1905117 regulation of ribonucleoside-diphosphate reductase activity [PMID:25378334]
experiment: EXISTENCE:genetic interaction:GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity [PMID:25378334]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:10490641]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:10490641]
note: Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; transcription is induced by genotoxic stress and by activation of the Rad53p pathway; protein abundance increases in response to DNA replication stress
codon start: 1
product: Hug1p
translation: MTMDQGLNPKQFFLDDVVLQDTLCSMSNRVNKSVKTGYLFPKDHVPSANIIAVERRGGLSDIGKNTSN
SIO_010081: YML058W-A
subclass of: SO_0000673
so part of: YML058W-A
location: 158760..158966
location: region:158760-158966:1
so has part: feature:158760-158966:1:exon

NP_219498.1
type: Protein
SIO_000068: ncbiprotein

S000007472
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:158760-158966:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1307.5; Autonomously replicating sequence
so part of: sequence
location: 158887..159277
location: region:158887-159277:1
so has part: feature:158887-159277:1:region

S000178152
type: SGD
SIO_000068: sgd

position:158887:1
position: 158887
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:159277:1
position: 159277
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:158887-159277:1:region

YML058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SML1
locus tag: YML058W
so part of: sequence
location: <159383..>159697
location: region:159383-159697:1
so has part: feature:159383-159697:1:exon
subclass of: SO_0000010

854945
type: Gene
SIO_000068: ncbigene

position:159383:1
position: 159383
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159697:1
position: 159697
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159383-159697:1:exon

YML058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SML1
locus tag: YML058W
product: ribonucleotide reductase inhibiting protein SML1
transcript id: NM_001182417.1
SIO_010081: YML058W
subclass of: SO_0000673
so part of: YML058W
location: <159383..>159697
location: region:159383-159697:1
so has part: feature:159383-159697:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159383-159697:1:exon

YML058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SML1
locus tag: YML058W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:1905117 regulation of ribonucleoside-diphosphate reductase activity [PMID:10593972]
experiment: EXISTENCE:direct assay:GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity [PMID:10593972|PMID:27155231]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:9774971]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:9774971]
note: Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication
codon start: 1
product: ribonucleotide reductase inhibiting protein SML1
translation: MQNSQDYFYAQNRCQQQQAPSTLRTVTMAEFRRVPLPPMAEVPMLSTQNSMGSSASASASSLEMWEKDLEERLNSIDHDMNNNKFGSGELKSMFNQGKVEEMDF
SIO_010081: YML058W
subclass of: SO_0000673
so part of: YML058W
location: 159383..159697
location: region:159383-159697:1
so has part: feature:159383-159697:1:exon

NP_013653.1
type: Protein
SIO_000068: ncbiprotein

S000004523
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159383-159697:1:exon

YML057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CNA2
gene: CMP2
locus tag: YML057W
gene synonym: CNA2
so part of: sequence
location: <160180..>161994
location: region:160180-161994:1
so has part: feature:160180-161994:1:exon
subclass of: SO_0000010

854946
type: Gene
SIO_000068: ncbigene

position:160180:1
position: 160180
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:161994:1
position: 161994
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160180-161994:1:exon

YML057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CNA2
gene: CMP2
locus tag: YML057W
gene synonym: CNA2
product: calcineurin catalytic subunit A
transcript id: NM_001182415.1
SIO_010081: YML057W
subclass of: SO_0000673
so part of: YML057W
location: <160180..>161994
location: region:160180-161994:1
so has part: feature:160180-161994:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160180-161994:1:exon

YML057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CNA2
gene: CMP2
locus tag: YML057W
gene synonym: CNA2
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004723 calcium-dependent protein serine/threonine phosphatase activity [PMID:1321337]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005955 calcineurin complex [PMID:1321337]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:1651503]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:8798496]
note: Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication
codon start: 1
product: calcineurin catalytic subunit A
translation: MSSDAIRNTEQINAAIKIIENKTERPQSSTTPIDSKASTVAAANSTATETSRDLTQYTLDDGRVVSTNRRIMNKVPAITSHVPTDEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDKDLTEEDIVNSKTMVPHHGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKTLGFPSLLTLFSAPNYLDTYNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNICTEDELENDTPVIEELVGTDKKLPQAGKSEATPQPATSASPKHASILDDEHRRKALRNKILAVAKVSRMYSVLREETNKVQFLKDHNSGVLPRGALSNGVKGLDEALSTFERARKHDLINEKLPPSLDELKNENKKYYEKVWQKVHEHDAKNDSK
SIO_010081: YML057W
subclass of: SO_0000673
so part of: YML057W
location: 160180..161994
location: region:160180-161994:1
so has part: feature:160180-161994:1:exon

NP_013655.1
type: Protein
SIO_000068: ncbiprotein

S000004521
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160180-161994:1:exon

YML056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMD4
locus tag: YML056C
so part of: sequence
location: complement(<162194..>164176)
location: region:162194-164176:-1
so has part: feature:162194-164176:-1:exon
subclass of: SO_0000010

854948
type: Gene
SIO_000068: ncbigene

position:162194:-1
position: 162194
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164176:-1
position: 164176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:162194-164176:-1:exon

YML056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMD4
locus tag: YML056C
product: IMP dehydrogenase IMD4
transcript id: NM_001182414.1
SIO_010081: YML056C
subclass of: SO_0000673
so part of: YML056C
location: complement(join(<162194..163308,163717..>164176))
location: region:162194-164176:-1
so has part: feature:163717-164176:-1:exon
so has part: feature:162194-163308:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:163717-164176:-1:exon

position:163717:-1
position: 163717
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:162194-163308:-1:exon

position:163308:-1
position: 163308
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMD4
locus tag: YML056C
EC number: 1.1.1.205
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]
note: Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication
codon start: 1
product: IMP dehydrogenase IMD4
translation: MSAAPLDYKKALEHLKTYSSKDGLSVQELMDSTTRGGLTYNDFLVLPGLVNFPSSAVSLQTKLTKKITLNTPFVSSPMDTVTEADMAIYMALLGGIGFIHHNCTPKEQASMVKKVKMFENGFINSPIVISPTTTVGEVKVMKRKFGFSGFPVTEDGKCPGKLVGLVTSRDIQFLEDDSLVVSEVMTKNPVTGIKGITLKEGNEILKQTKKGKLLIVDDNGNLVSMLSRADLMKNQNYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVVILDSSQGNSVFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVCQFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCESLTSLKENVQNGEVRFEFRTASAQLEGGVHNLHSYEKRLYN
SIO_010081: YML056C
subclass of: SO_0000673
so part of: YML056C
location: complement(join(162194..163308,163717..164176))
location: region:162194-164176:-1
so has part: feature:163717-164176:-1:exon
so has part: feature:162194-163308:-1:exon

NP_013656.1
type: Protein
SIO_000068: ncbiprotein

S000004520
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:163717-164176:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:162194-163308:-1:exon

YNCM0005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR54
locus tag: YNCM0005C
so part of: sequence
location: complement(163535..163620)
location: region:163535-163620:-1
so has part: feature:163535-163620:-1:exon
subclass of: SO_0000578

9164960
type: Gene
SIO_000068: ncbigene

position:163535:-1
position: 163535
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:163620:-1
position: 163620
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:163535-163620:-1:exon

YNCM0005C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR54
locus tag: YNCM0005C
product: SNR54
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position A974
transcript id: NR_132236.1
SIO_010081: YNCM0005C
subclass of: SO_0000673
so part of: YNCM0005C
location: complement(163535..163620)
location: region:163535-163620:-1
so has part: feature:163535-163620:-1:exon

S000006445
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:163535-163620:-1:exon

YML055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPY1
gene: SPC2
locus tag: YML055W
gene synonym: SPY1
so part of: sequence
location: <164790..>165326
location: region:164790-165326:1
so has part: feature:164790-165326:1:exon
subclass of: SO_0000010

854949
type: Gene
SIO_000068: ncbigene

position:164790:1
position: 164790
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:165326:1
position: 165326
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164790-165326:1:exon

YML055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPY1
gene: SPC2
locus tag: YML055W
gene synonym: SPY1
product: signal peptidase complex subunit SPC2
transcript id: NM_001182413.1
SIO_010081: YML055W
subclass of: SO_0000673
so part of: YML055W
location: <164790..>165326
location: region:164790-165326:1
so has part: feature:164790-165326:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164790-165326:1:exon

YML055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPY1
gene: SPC2
locus tag: YML055W
gene synonym: SPY1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:1846444|PMID:8910564]
experiment: EXISTENCE:genetic interaction:GO:0045047 protein targeting to ER [PMID:8910564]
experiment: EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:10921929]
experiment: EXISTENCE:mutant phenotype:GO:0008233 peptidase activity [PMID:10921929]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:8910564]
experiment: EXISTENCE:mutant phenotype:GO:0120236 negative regulation of post-translational protein targeting to membrane, translocation [PMID:32513868]
experiment: EXISTENCE:physical interaction:GO:0045047 protein targeting to ER [PMID:8910564]
note: Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p
codon start: 1
product: signal peptidase complex subunit SPC2
translation: MSSAKPINVYSIPELNQALDEALPSVFARLNYERSYALLDAKLYIGYSIAVVAGLSFFLDKKFERDQIVTYQKLLVGAYFVLSLLFWYFSRFIEKGTVYVGKRRGTKEEIYVKTKFEKNEPLYLVELVQKKKGENSKKELKAKLEVNKVFNESGYLQNDAYFKWFSEQHNVLDTKKNE
SIO_010081: YML055W
subclass of: SO_0000673
so part of: YML055W
location: 164790..165326
location: region:164790-165326:1
so has part: feature:164790-165326:1:exon

NP_013657.1
type: Protein
SIO_000068: ncbiprotein

S000004519
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164790-165326:1:exon

YML054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FCB2
gene: CYB2
locus tag: YML054C
gene synonym: FCB2
so part of: sequence
location: complement(<165533..>167308)
location: region:165533-167308:-1
so has part: feature:165533-167308:-1:exon
subclass of: SO_0000010

854950
type: Gene
SIO_000068: ncbigene

position:165533:-1
position: 165533
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167308:-1
position: 167308
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:165533-167308:-1:exon

YML054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FCB2
gene: CYB2
locus tag: YML054C
gene synonym: FCB2
product: L-lactate dehydrogenase (cytochrome)
transcript id: NM_001182412.1
SIO_010081: YML054C
subclass of: SO_0000673
so part of: YML054C
location: complement(<165533..>167308)
location: region:165533-167308:-1
so has part: feature:165533-167308:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:165533-167308:-1:exon

YML054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FCB2
gene: CYB2
locus tag: YML054C
gene synonym: FCB2
EC number: 1.1.2.3
experiment: EXISTENCE:direct assay:GO:0004460 L-lactate dehydrogenase (cytochrome) activity [PMID:3004948]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:3004948|PMID:6290489]
experiment: EXISTENCE:mutant phenotype:GO:0006089 lactate metabolic process [PMID:8492799]
note: Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
codon start: 1
product: L-lactate dehydrogenase (cytochrome)
translation: MLKYKPLLKISKNCEAAILRASKTRLNTIRAYGSTVPKSKSFEQDSRKRTQSWTALRVGAILAATSSVAYLNWHNGQIDNEPKLDMNKQKISPAEVAKHNKPDDCWVVINGYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPPYAPGETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGANDEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATALCKLGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFSNTKAGPKAMKKTNVEESQGASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
SIO_010081: YML054C
subclass of: SO_0000673
so part of: YML054C
location: complement(165533..167308)
location: region:165533-167308:-1
so has part: feature:165533-167308:-1:exon

NP_013658.1
type: Protein
SIO_000068: ncbiprotein

S000004518
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:165533-167308:-1:exon

YML054C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML054C-A
so part of: sequence
location: complement(<167623..>167781)
location: region:167623-167781:-1
so has part: feature:167623-167781:-1:exon
subclass of: SO_0000010

1466497
type: Gene
SIO_000068: ncbigene

position:167623:-1
position: 167623
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167781:-1
position: 167781
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167623-167781:-1:exon

YML054C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML054C-A
product: uncharacterized protein
transcript id: NM_001184571.1
SIO_010081: YML054C-A
subclass of: SO_0000673
so part of: YML054C-A
location: complement(<167623..>167781)
location: region:167623-167781:-1
so has part: feature:167623-167781:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167623-167781:-1:exon

YML054C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML054C-A
codon start: 1
product: uncharacterized protein
translation: MIPFPAQHEIFHAYIGRITPHSSRCIANMWHSAHFFHENSLSIMKTLVPWTL
SIO_010081: YML054C-A
subclass of: SO_0000673
so part of: YML054C-A
location: complement(167623..167781)
location: region:167623-167781:-1
so has part: feature:167623-167781:-1:exon

NP_878139.1
type: Protein
SIO_000068: ncbiprotein

S000028573
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167623-167781:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(168349..168681)
location: region:168349-168681:-1
so has part: feature:168349-168681:-1:region

S000007102
type: SGD
SIO_000068: sgd

position:168349:-1
position: 168349
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:168681:-1
position: 168681
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168349-168681:-1:region

YNCM0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUP5
locus tag: YNCM0006W
so part of: sequence
location: 168795..168883
location: region:168795-168883:1
so has part: feature:168795-168883:1:exon
subclass of: SO_0000663

854951
type: Gene
SIO_000068: ncbigene

position:168795:1
position: 168795
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:168883:1
position: 168883
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168795-168883:1:exon

YNCM0006W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUP5
locus tag: YNCM0006W
product: tRNA-Tyr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations
SIO_010081: YNCM0006W
subclass of: SO_0000673
so part of: YNCM0006W
location: join(168795..168833,168848..168883)
location: region:168795-168883:1
so has part: feature:168795-168833:1:exon
so has part: feature:168848-168883:1:exon

S000006783
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:168795-168833:1:exon

position:168833:1
position: 168833
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:168848-168883:1:exon

position:168848:1
position: 168848
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML053C
so part of: sequence
location: complement(<169116..>169754)
location: region:169116-169754:-1
so has part: feature:169116-169754:-1:exon
subclass of: SO_0000010

854952
type: Gene
SIO_000068: ncbigene

position:169116:-1
position: 169116
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169754:-1
position: 169754
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169116-169754:-1:exon

YML053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML053C
product: uncharacterized protein
transcript id: NM_001182411.1
SIO_010081: YML053C
subclass of: SO_0000673
so part of: YML053C
location: complement(<169116..>169754)
location: region:169116-169754:-1
so has part: feature:169116-169754:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:169116-169754:-1:exon

YML053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML053C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MLSYYEHNTAFQTNNCNSGSNAATTYNSDANNDTIMNKRKNDHFEFDTHTFYQRSKRTKRDSVSTKFSVGSGCANLNNNNNNIIINNNNNNNNNNNNHNHNNSNNTATYNNIHYKKNIEICPLKPVSMHHTMNSRLLNESEFYSETEEYMIHGYFGNTNRDITGTSPTGSASIIQHQYHLLPSQSIIASQAPGTAMAALTNNNIANDYMDID
SIO_010081: YML053C
subclass of: SO_0000673
so part of: YML053C
location: complement(169116..169754)
location: region:169116-169754:-1
so has part: feature:169116-169754:-1:exon

NP_013659.1
type: Protein
SIO_000068: ncbiprotein

S000004517
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:169116-169754:-1:exon

YML052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUR7
locus tag: YML052W
so part of: sequence
location: <170402..>171310
location: region:170402-171310:1
so has part: feature:170402-171310:1:exon
subclass of: SO_0000010

854953
type: Gene
SIO_000068: ncbigene

position:170402:1
position: 170402
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171310:1
position: 171310
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:170402-171310:1:exon

YML052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SUR7
locus tag: YML052W
product: Sur7p
transcript id: NM_001182410.1
SIO_010081: YML052W
subclass of: SO_0000673
so part of: YML052W
location: <170402..>171310
location: region:170402-171310:1
so has part: feature:170402-171310:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:170402-171310:1:exon

YML052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SUR7
locus tag: YML052W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:17507646]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867|PMID:16496001]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122|PMID:16496001]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16496001]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]
experiment: EXISTENCE:mutant phenotype:GO:0097446 protein localization to eisosome filament [PMID:25811606]
note: Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)
codon start: 1
product: Sur7p
translation: MVKVWNIVLRLVVLLFLAGNTLLLILMIISGATDHYPVNRFYWVQGNTTGIPNAGDETRWTFWGACLQDKDGSDTCTSNLAPAYPISPVDNFNTHINVPHQFISKRDAFYYLTRFSFCFFWIALAFVGVSFILYVLTWCSKMLSEMVLILMSFGFVFNTAAVVLQTAASAMAKNAFHDDHRSAQLGASMMGMAWASVFLCIVEFILLVFWSVRARLASTYSIDNSRYRTSSRWNPFHREKEQATDPILTATGPEDMQQSASIVGPSSNANPVTATAATENQPKGINFFTIRKSHERPDDVSV
SIO_010081: YML052W
subclass of: SO_0000673
so part of: YML052W
location: 170402..171310
location: region:170402-171310:1
so has part: feature:170402-171310:1:exon

NP_013660.1
type: Protein
SIO_000068: ncbiprotein

S000004516
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:170402-171310:1:exon

YML051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAL80
locus tag: YML051W
so part of: sequence
location: <171594..>172901
location: region:171594-172901:1
so has part: feature:171594-172901:1:exon
subclass of: SO_0000010

854954
type: Gene
SIO_000068: ncbigene

position:171594:1
position: 171594
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:172901:1
position: 172901
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171594-172901:1:exon

YML051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAL80
locus tag: YML051W
product: transcription regulator GAL80
transcript id: NM_001182409.1
SIO_010081: YML051W
subclass of: SO_0000673
so part of: YML051W
location: <171594..>172901
location: region:171594-172901:1
so has part: feature:171594-172901:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171594-172901:1:exon

YML051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAL80
locus tag: YML051W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10866670|PMID:18952899]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10866670|PMID:18952899]
experiment: EXISTENCE:direct assay:GO:0019210 kinase inhibitor activity [PMID:18957435]
experiment: EXISTENCE:direct assay:GO:0033673 negative regulation of kinase activity [PMID:18957435]
experiment: EXISTENCE:direct assay:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:9811836]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9811836]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:6092916]
experiment: EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:6092916]
experiment: EXISTENCE:physical interaction:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:9811836]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9811836]
note: Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
codon start: 1
product: transcription regulator GAL80
translation: MDYNKRSSVSTVPNAAPIRVGFVGLNAAKGWAIKTHYPAILQLSSQFQITALYSPKIETSIATIQRLKLSNATAFPTLESFASSSTIDMIVIAIQVASHYEVVMPLLEFSKNNPNLKYLFVEWALACSLDQAESIYKAAAERGVQTIISLQGRKSPYILRAKELISQGYIGDINSIEIAGNGGWYGYERPVKSPKYIYEIGNGVDLVTTTFGHTIDILQYMTSSYFSRINAMVFNNIPEQELIDERGNRLGQRVPKTVPDHLLFQGTLLNGNVPVSCSFKGGKPTKKFTKNLVIDIHGTKGDLKLEGDAGFAEISNLVLYYSGTRANDFPLANGQQAPLDPGYDAGKEIMEVYHLRNYNAIVGNIHRLYQSISDFHFNTKKIPELPSQFVMQGFDFEGFPTLMDALILHRLIESVYKSNMMGSTLNVSNISHYSL
SIO_010081: YML051W
subclass of: SO_0000673
so part of: YML051W
location: 171594..172901
location: region:171594-172901:1
so has part: feature:171594-172901:1:exon

NP_013661.1
type: Protein
SIO_000068: ncbiprotein

S000004515
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171594-172901:1:exon

YML050W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM32
locus tag: YML050W
so part of: sequence
location: <173139..>174074
location: region:173139-174074:1
so has part: feature:173139-174074:1:exon
subclass of: SO_0000010

854955
type: Gene
SIO_000068: ncbigene

position:173139:1
position: 173139
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174074:1
position: 174074
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:173139-174074:1:exon

YML050W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM32
locus tag: YML050W
product: Aim32p
transcript id: NM_001182408.1
SIO_010081: YML050W
subclass of: SO_0000673
so part of: YML050W
location: <173139..>174074
location: region:173139-174074:1
so has part: feature:173139-174074:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:173139-174074:1:exon

YML050W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM32
locus tag: YML050W
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:34461091]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:30879301|PMID:34461091]
experiment: EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:34461091]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:34461091]
note: 2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1
codon start: 1
product: Aim32p
translation: MLRITVKTLQQRASFHHSFKHISVPDLHTRAQNDQTNCYCQEINARLPSKTDPLDPHIKLPHRTPNYNKHVLLLSPGDRFAQPWKVAWNHNLDTNTNRPYNAISKLRSHLGGSPGILINAVHLQNEFIPRPKQHDEWLYFFVIPDMKLYVIKETDIEEFASFLDEGAIQAPKLSFQDYLSGKAKASQQVHEVHHRKLTRFQGETFLRDWNLVCGHYKRDAKCGEMGPDIIAAFQDEKLFPENNLALISHIGGHIFAGNVIFYKLFGREKMQNKLDSLWFGKVYPHNLKLLCENLENGKIIDEMYRGGISMN
SIO_010081: YML050W
subclass of: SO_0000673
so part of: YML050W
location: 173139..174074
location: region:173139-174074:1
so has part: feature:173139-174074:1:exon

NP_013662.1
type: Protein
SIO_000068: ncbiprotein

S000004514
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:173139-174074:1:exon

YML049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSE1
locus tag: YML049C
so part of: sequence
location: complement(<174220..>178305)
location: region:174220-178305:-1
so has part: feature:174220-178305:-1:exon
subclass of: SO_0000010

854956
type: Gene
SIO_000068: ncbigene

position:174220:-1
position: 174220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:178305:-1
position: 178305
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:174220-178305:-1:exon

YML049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSE1
locus tag: YML049C
product: U2 snRNP complex subunit RSE1
transcript id: NM_001182407.1
SIO_010081: YML049C
subclass of: SO_0000673
so part of: YML049C
location: complement(<174220..>178305)
location: region:174220-178305:-1
so has part: feature:174220-178305:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:174220-178305:-1:exon

YML049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSE1
locus tag: YML049C
experiment: EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:10369685]
experiment: EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]
experiment: EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:10369685]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9819400]
experiment: EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]
note: Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
codon start: 1
product: U2 snRNP complex subunit RSE1
translation: MWGGGKMAVVSLSPHTAKMRKLFGQASTTMAYDGLKREAERRTRSDHNITMVAKDDELYLYHLTLKKQTNFVHSCIGHFVDLEAGSKREQSQLCVATETHLELYDTADGELKLIAKFQNLFATITSMKSLDLPHSGSRAKASNWPTFLALTSDSGNLSIVQIIMHAGALRLKTLVNQPLTRTTLRRVSPISYMEIDPNGRCIILSSVEQNKLCFLVDYAQKLRISSPLEIIRPHMVTLDMAVVDVNFNNPCFVTLEIDNAATQLSVHLIFYVLELGLNHIVKKADYLVNPSANFVLSLPDLSRYNITTSLSDNNYDADYDTLFNPFVVIGFENHILVKDMNGFFSLKVEIPKRSITNSRHKNVTIISGIVQKLKNDFFVLLQSNHGDLFKLTVSPDTNDRNRPLVQLSYFDTIQNSHQLHIFKNGYLFALSEMNNNFLFQFEKLGVEKNDFSNVLTSKDPNKSLVFEPSIKLQNLSILSQQLNLNPSIKSQIVSDSPLSIATKHFTNNKIITLTNAVNYSNLISTSLPPNATKLWLIPDPATTGDNNTLLFITFPKKTMILQIDNESMEELTPDEATRSAFKLSQDTTIHTCLMGSHSIIQVCTAELRHIVPTGKSRYSNKLTWVPPAGIRIVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELTTHPELDTMPSKVAIVQDTQHADLLAIADNEGMIKIMSLKDQKEDFLTVISLQLVSEKISDMIMVRDSSIGQLNLHVGLENGVYMKFHIGDVDGSFTDIKRRFLGLKPVSLSYLREISVSLNNEEEEEEEEDDDDEKEEEEINSSGAKWMSCVVCHSSSTWVSYTWKNVWTIRQLKDQNMLSCSKFVNADVAINGVCSISSSGRLNIGRVSNFPTLDNWFHVHESSVNKQENGGGDESNEEEEDEMEEEMEMLQISTFRPRTILSFPNNPKSILFIDNHSGKKQCRISLQIDGECLKFGSSDHLYKILDDIDCVSAAIIDFTRQADHLIICAGDKRLLTYKILVNKDKLSFDIELLHQTEIISPIHAMLKFKNFLLTAMGSTIVLYGLGKKQLLRRSVTQTPVSITKIVSMHQWNYERLAVGDIHESVTLFIWDPAGNVFIPYVDDSVKRHVTVLKFLDEATVIGADRYGNAWTLRSPPECEKIMSNHDPSELSNGAIKYPLDVITLQQKLPNTYDCKFKFQLLNHFFVNDIITDFHILDSLSNSDRPGCIYMGLQGTVGCFIPLLSKGNVFMMGNIENIMAEADDTFYLDYESRKKNNNMRKEDDEEESGSVVLQGRHGIEDEIICEGSCSILGRDHQEYRSYYAPVRKVIDGDLCENFLRLSLNEQEFLAKNLKSVQVEDIIQTINEVRTNYM
SIO_010081: YML049C
subclass of: SO_0000673
so part of: YML049C
location: complement(174220..178305)
location: region:174220-178305:-1
so has part: feature:174220-178305:-1:exon

NP_013663.1
type: Protein
SIO_000068: ncbiprotein

S000004513
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:174220-178305:-1:exon

YML048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECM6
gene: GSF2
locus tag: YML048W
gene synonym: ECM6
so part of: sequence
location: <178426..>179637
location: region:178426-179637:1
so has part: feature:178426-179637:1:exon
subclass of: SO_0000010

854957
type: Gene
SIO_000068: ncbigene

position:178426:1
position: 178426
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:179637:1
position: 179637
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178426-179637:1:exon

YML048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECM6
gene: GSF2
locus tag: YML048W
gene synonym: ECM6
product: Gsf2p
transcript id: NM_001182405.1
SIO_010081: YML048W
subclass of: SO_0000673
so part of: YML048W
location: <178426..>179637
location: region:178426-179637:1
so has part: feature:178426-179637:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178426-179637:1:exon

YML048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECM6
gene: GSF2
locus tag: YML048W
gene synonym: ECM6
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10377429]
experiment: EXISTENCE:genetic interaction:GO:0034394 protein localization to cell surface [PMID:10377429]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]
experiment: EXISTENCE:mutant phenotype:GO:0034394 protein localization to cell surface [PMID:10377429]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]
note: Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
codon start: 1
product: Gsf2p
translation: MEIYIRLNADVEHDYAFQVSNEDTINNKIKKIFPSKTGLADLMVLRPSIFHEKEPVKFYKSIHPGYLSEGGCLMFHYEADNEENLEELNDSKPLIDQLWPGQLVVPEWKLSKKNIWVYTIIMLAWLYTDLPDAISPTPGICLTNQLSRLLIPVAKHMDLPEIAAKLEQEVQANYSSLVAQWLFFVMHIFKVGIITLFLKLGIANPISFNPYKLWSLRDLTSPSANGAKNSGGNNNTTDLKTRLRSLGWIGAKRATYDDYQTNYYNYVIDKMGGAVAAYRAGAIRKAAAPGIQLVAGEGFQSPLEDRFTASTFTAIKTERKFILSEEYFVELENNLKKILEEYDGDIGKMNAEIRRFRRFGIYEPDEKLASLVKLRREIADEKEKASNNDATFGIKKNDLKKSN
SIO_010081: YML048W
subclass of: SO_0000673
so part of: YML048W
location: 178426..179637
location: region:178426-179637:1
so has part: feature:178426-179637:1:exon

NP_013664.1
type: Protein
SIO_000068: ncbiprotein

S000004511
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178426-179637:1:exon

YML047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KCH2
gene: PRM6
locus tag: YML047C
gene synonym: KCH2
so part of: sequence
location: complement(<180017..>181075)
location: region:180017-181075:-1
so has part: feature:180017-181075:-1:exon
subclass of: SO_0000010

854959
type: Gene
SIO_000068: ncbigene

position:180017:-1
position: 180017
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181075:-1
position: 181075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180017-181075:-1:exon

YML047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KCH2
gene: PRM6
locus tag: YML047C
gene synonym: KCH2
product: pheromone-regulated K(+) transporter PRM6
transcript id: NM_001182404.1
SIO_010081: YML047C
subclass of: SO_0000673
so part of: YML047C
location: complement(<180017..>181075)
location: region:180017-181075:-1
so has part: feature:180017-181075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180017-181075:-1:exon

YML047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KCH2
gene: PRM6
locus tag: YML047C
gene synonym: KCH2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23204190]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:23204190]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:23204190]
experiment: EXISTENCE:genetic interaction:GO:0015079 potassium ion transmembrane transporter activity [PMID:23204190]
experiment: EXISTENCE:genetic interaction:GO:0071805 potassium ion transmembrane transport [PMID:23204190]
note: Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication
codon start: 1
product: pheromone-regulated K(+) transporter PRM6
translation: MESSLQKLKFQDIDINLIPTAKWTTKLQYILYTWCQSILHVAMFFSDIYTCIKLLAFNTWSNNIIQPFLEFRISKWLFSGCILCSSLILIWELVIGLRVYRKKEITSNYMNGISRLINCLFNFKKYQIFELIVLTDEKKFSKWLFFSYFEISGCLRLLFGDSPRQIINGLTLWSVLLTVSNETSSGTHSTQSLGNLDDLNGIINKIKHIAKTNYEESVILSFMLFSFIIWVILISKLILSIIIFIIFIRPRFLSSKRKVKGYELKLRKYVSKVIDENLSRTVYELGILIDDEEEGTICGDNKTQKKFDYDSPDYGDESTIPSYYCYSDVETYERVYTPIKAYFPQKYKHKYI
SIO_010081: YML047C
subclass of: SO_0000673
so part of: YML047C
location: complement(180017..181075)
location: region:180017-181075:-1
so has part: feature:180017-181075:-1:exon

NP_013666.1
type: Protein
SIO_000068: ncbiprotein

S000004510
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180017-181075:-1:exon

YML046W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP39
locus tag: YML046W
so part of: sequence
location: <181474..>183363
location: region:181474-183363:1
so has part: feature:181474-183363:1:exon
subclass of: SO_0000010

854960
type: Gene
SIO_000068: ncbigene

position:181474:1
position: 181474
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:183363:1
position: 183363
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181474-183363:1:exon

YML046W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP39
locus tag: YML046W
product: Prp39p
transcript id: NM_001182403.1
SIO_010081: YML046W
subclass of: SO_0000673
so part of: YML046W
location: <181474..>183363
location: region:181474-183363:1
so has part: feature:181474-183363:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181474-183363:1:exon

YML046W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP39
locus tag: YML046W
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:8196608|PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:genetic interaction:GO:0000243 commitment complex [PMID:8196608]
experiment: EXISTENCE:genetic interaction:GO:0000395 mRNA 5'-splice site recognition [PMID:8196608]
experiment: EXISTENCE:genetic interaction:GO:0030627 pre-mRNA 5'-splice site binding [PMID:8196608]
note: U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats
codon start: 1
product: Prp39p
translation: MPDETNFTIEDIEPRPDALRGLDTQFLQDNTALVQAYRGLDWSDISSLTQMVDVIEQTVVKYGNPNDSIKLALETILWQILRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVNNPNETDFIRNNFEIAKDLIGKQFLSHPFWDKFIEFEVGQKNWHNVQRIYEYIIEVPLHQYARFFTSYKKFLNEKNLKTTRNIDIVLRKTQTTVNEIWQFESKIKQPFFNLGQVLNDDLENWSRYLKFVTDPSKSLDKEFVMSVFDRCLIPCLYHENTWMMYIKWLTKKNISDEVVVDIYQKANTFLPLDFKTLRYDFLRFLKRKYRSNNTLFNNIFNETVSRYLKIWPNDILLMTEYLCMLKRHSFKNSLDQSPKEILEKQTSFTKILETSITNYINNQIDAKVHLQTLINDKNLSIVVVELIKTTWLVLKNNMQTRKYFNLYQKNILIKNSVPFWLTYYKFEKSNVNFTKLNKFIRELGVEIYLPTTVMNDILTDYKTFYLTHSNIVTYESSIIDSNTFDPILYPELKMSNPKYDPVLNTTANVDWHKKTEWKEAGHIGITTERPQISNSIIECNSGTLIQKPISLPNFRNLEKINQVKINDLYTEEFLKEGK
SIO_010081: YML046W
subclass of: SO_0000673
so part of: YML046W
location: 181474..183363
location: region:181474-183363:1
so has part: feature:181474-183363:1:exon

NP_013667.1
type: Protein
SIO_000068: ncbiprotein

S000004509
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181474-183363:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1308; Autonomously Replicating Sequence
so part of: sequence
location: 183797..183887
location: region:183797-183887:1
so has part: feature:183797-183887:1:region

S000118368
type: SGD
SIO_000068: sgd

position:183797:1
position: 183797
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:183887:1
position: 183887
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:183797-183887:1:region

YNCM0007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0007C
so part of: sequence
location: complement(183898..183968)
location: region:183898-183968:-1
so has part: feature:183898-183968:-1:exon
subclass of: SO_0000663

854961
type: Gene
SIO_000068: ncbigene

position:183898:-1
position: 183898
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:183968:-1
position: 183968
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:183898-183968:-1:exon

YNCM0007C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0007C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0007C
subclass of: SO_0000673
so part of: YNCM0007C
location: complement(183898..183968)
location: region:183898-183968:-1
so has part: feature:183898-183968:-1:exon

S000006585
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:183898-183968:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YMLWTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YMLWTy1-1
so part of: sequence
location: 184170..190083
location: region:184170-190083:1
so has part: feature:184170-190083:1:region

S000007107
type: SGD
SIO_000068: sgd

position:184170:1
position: 184170
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:190083:1
position: 190083
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184170-190083:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 184170..184501
location: region:184170-184501:1
so has part: feature:184170-184501:1:region

S000007103
type: SGD
SIO_000068: sgd

position:184501:1
position: 184501
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184170-184501:1:region

YML045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML045W
so part of: sequence
location: <184461..>189729
location: region:184461-189729:1
so has part: feature:184461-189729:1:exon
subclass of: SO_0000010

854963
type: Gene
SIO_000068: ncbigene

position:184461:1
position: 184461
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:189729:1
position: 189729
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184461-189729:1:exon

YML045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML045W
product: gag-pol fusion protein
transcript id: NM_001182402.2
SIO_010081: YML045W
subclass of: SO_0000673
so part of: YML045W
location: <184461..>189729
location: region:184461-189729:1
so has part: feature:184461-189729:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184461-189729:1:exon

YML045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML045W
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPNISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YML045W
subclass of: SO_0000673
so part of: YML045W
location: join(184461..185765,185767..189729)
location: region:184461-189729:1
so has part: feature:184461-185765:1:exon
so has part: feature:185767-189729:1:exon

NP_013668.1
type: Protein
SIO_000068: ncbiprotein

S000004508
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184461-185765:1:exon

position:185765:1
position: 185765
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:185767-189729:1:exon

position:185767:1
position: 185767
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML045W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML045W-A
so part of: sequence
location: <184461..>185783
location: region:184461-185783:1
so has part: feature:184461-185783:1:exon
subclass of: SO_0000010

854962
type: Gene
SIO_000068: ncbigene

position:185783:1
position: 185783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184461-185783:1:exon

YML045W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML045W-A
product: gag protein
transcript id: NM_001184412.1
SIO_010081: YML045W-A
subclass of: SO_0000673
so part of: YML045W-A
location: <184461..>185783
location: region:184461-185783:1
so has part: feature:184461-185783:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184461-185783:1:exon

YML045W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML045W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPNISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YML045W-A
subclass of: SO_0000673
so part of: YML045W-A
location: 184461..185783
location: region:184461-185783:1
so has part: feature:184461-185783:1:exon

NP_058176.1
type: Protein
SIO_000068: ncbiprotein

S000007381
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184461-185783:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 189752..190083
location: region:189752-190083:1
so has part: feature:189752-190083:1:region

S000007104
type: SGD
SIO_000068: sgd

position:189752:1
position: 189752
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:189752-190083:1:region

YML043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRN11
locus tag: YML043C
so part of: sequence
location: complement(<190244..>191767)
location: region:190244-191767:-1
so has part: feature:190244-191767:-1:exon
subclass of: SO_0000010

854964
type: Gene
SIO_000068: ncbigene

position:190244:-1
position: 190244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:191767:-1
position: 191767
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:190244-191767:-1:exon

YML043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRN11
locus tag: YML043C
product: Rrn11p
transcript id: NM_001182401.1
SIO_010081: YML043C
subclass of: SO_0000673
so part of: YML043C
location: complement(<190244..>191767)
location: region:190244-191767:-1
so has part: feature:190244-191767:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:190244-191767:-1:exon

YML043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRN11
locus tag: YML043C
experiment: EXISTENCE:curator inference:GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding []
experiment: EXISTENCE:direct assay:GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding [PMID:18451108]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23613772]
experiment: EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:8702872]
experiment: EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8887672]
experiment: EXISTENCE:direct assay:GO:0070860 RNA polymerase I core factor complex [PMID:8702872|PMID:8887672]
experiment: EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8702872]
experiment: EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8702872]
experiment: EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8702872]
note: Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
codon start: 1
product: Rrn11p
translation: MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEGQNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKEDSDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLDKGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEFLDTQLMDLSPEDNGLDEMHYSDEDSSE
SIO_010081: YML043C
subclass of: SO_0000673
so part of: YML043C
location: complement(190244..191767)
location: region:190244-191767:-1
so has part: feature:190244-191767:-1:exon

NP_013669.1
type: Protein
SIO_000068: ncbiprotein

S000004507
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:190244-191767:-1:exon

YML042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YCAT
gene: CAT2
locus tag: YML042W
gene synonym: YCAT
so part of: sequence
location: <192788..>194800
location: region:192788-194800:1
so has part: feature:192788-194800:1:exon
subclass of: SO_0000010

854965
type: Gene
SIO_000068: ncbigene

position:192788:1
position: 192788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194800:1
position: 194800
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:192788-194800:1:exon

YML042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YCAT
gene: CAT2
locus tag: YML042W
gene synonym: YCAT
product: carnitine O-acetyltransferase CAT2
transcript id: NM_001182400.1
SIO_010081: YML042W
subclass of: SO_0000673
so part of: YML042W
location: <192788..>194800
location: region:192788-194800:1
so has part: feature:192788-194800:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:192788-194800:1:exon

YML042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YCAT
gene: CAT2
locus tag: YML042W
gene synonym: YCAT
EC number: 2.3.1.7
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18427809|PMID:14576278|PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:18427809|PMID:22375831]
experiment: EXISTENCE:mutant phenotype:GO:0004092 carnitine O-acetyltransferase activity [PMID:8420957]
experiment: EXISTENCE:mutant phenotype:GO:0009437 carnitine metabolic process [PMID:11329169]
note: Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
codon start: 1
product: carnitine O-acetyltransferase CAT2
translation: MRICHSRTLSNLKDLPITSRRAMHSAIVNYSTQKAQFPVETNNGEHYWAEKPNKFYQNKRPNFQGITFAKQQDLPSLPVPELKSTLDKYLQTIRPFCNDVETFERQQLLCKDFSEHMGPILQDRLKEYANDKRNWMAKFWDEQSYLQYNDPIVPYVSYFYSHMPLPNHLSKIDNDPLIKATAIISTVVKFIEAIKDESLPVEIIKGMPFCMNSFSLMFNTSRLPGKPEDNQDTNIFYSVYENNFVTIAYKGKFYKLMTHDGNDKPLSENEIWRQLYSVVFQGSQSDPKLGGIGSLTSLPRDQWREVHLELMKDPISQDSLETIHKSSFMLCLDLDQSPVTLEEKSRNCWHGDGINRFYDKSLQFLVTGNGSSGFLAEHSKMDGTPTLFLNNYVCQQLNKLDVDDFMRKVITPSSTVAMKPMELPFIITPKIHKAIESAQLQFKETIGEHDLRVWHYNKYGKTFIKRHGMSPDAFIQQVIQLAVFKYLKRQLPTYEAASTRKYFKGRTETGRSVSTASLEFVSKWQNGDVPIAEKIQALKHSAKEHSTYLKNAANGNGVDRHFFGLKNMLKSNDDQIPPLFKDPLFNYSSTWLISTSQLSSEYFDGYGWSQVNDNGFGLAYMLNNEWLHINIVNKPAKSGASVNRLHYYLSQAADEIFDALENENKRKAKL
SIO_010081: YML042W
subclass of: SO_0000673
so part of: YML042W
location: 192788..194800
location: region:192788-194800:1
so has part: feature:192788-194800:1:exon

NP_013670.1
type: Protein
SIO_000068: ncbiprotein

S000004506
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:192788-194800:1:exon

YML041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SWC6
gene: VPS71
locus tag: YML041C
gene synonym: SWC6
so part of: sequence
location: complement(<194913..>195755)
location: region:194913-195755:-1
so has part: feature:194913-195755:-1:exon
subclass of: SO_0000010

854966
type: Gene
SIO_000068: ncbigene

position:194913:-1
position: 194913
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:195755:-1
position: 195755
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194913-195755:-1:exon

YML041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SWC6
gene: VPS71
locus tag: YML041C
gene synonym: SWC6
product: Vps71p
transcript id: NM_001182399.1
SIO_010081: YML041C
subclass of: SO_0000673
so part of: YML041C
location: complement(<194913..>195755)
location: region:194913-195755:-1
so has part: feature:194913-195755:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194913-195755:-1:exon

YML041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SWC6
gene: VPS71
locus tag: YML041C
gene synonym: SWC6
experiment: EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
experiment: EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16299513]
note: Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
codon start: 1
product: Vps71p
translation: MKALVEEIDKKTYNPDIYFTSLDPQARRYTSKKINKQGTISTSRPVKRINYSLADLEARLYTSRSEGDGNSISRQDDRNSKNSHSFEERYTQQEILQSDRRFMELNTENFSDLPNVPTLLSDLTGVPRDRIESTTKPISQTSDGLSALMGGSSFVKEHSKYGHGWVLKPETLREIQLSYKSTKLPKPKRKNTNRIVALKKVLSSKRNLHSFLDSALLNLMDKNVIYHNVYNKRYFKVLPLITTCSICGGYDSISSCVNCGNKICSVSCFKLHNETRCRNR
SIO_010081: YML041C
subclass of: SO_0000673
so part of: YML041C
location: complement(194913..195755)
location: region:194913-195755:-1
so has part: feature:194913-195755:-1:exon

NP_013671.1
type: Protein
SIO_000068: ncbiprotein

S000004505
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194913-195755:-1:exon

YNCM0008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF7
locus tag: YNCM0008C
so part of: sequence
location: complement(196068..196170)
location: region:196068-196170:-1
so has part: feature:196068-196170:-1:exon
subclass of: SO_0000663

854967
type: Gene
SIO_000068: ncbigene

position:196068:-1
position: 196068
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:196170:-1
position: 196170
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196068-196170:-1:exon

YNCM0008C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF7
locus tag: YNCM0008C
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin; can mutate to suppress +1 frameshift mutations in proline codons
SIO_010081: YNCM0008C
subclass of: SO_0000673
so part of: YNCM0008C
location: complement(join(196068..196103,196135..196170))
location: region:196068-196170:-1
so has part: feature:196135-196170:-1:exon
so has part: feature:196068-196103:-1:exon

S000006684
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196135-196170:-1:exon

position:196135:-1
position: 196135
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:196068-196103:-1:exon

position:196103:-1
position: 196103
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YMLWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YMLWTy1-2
so part of: sequence
location: 196332..202234
location: region:196332-202234:1
so has part: feature:196332-202234:1:region

S000007108
type: SGD
SIO_000068: sgd

position:196332:1
position: 196332
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:202234:1
position: 202234
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196332-202234:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 196332..196668
location: region:196332-196668:1
so has part: feature:196332-196668:1:region

S000007105
type: SGD
SIO_000068: sgd

position:196668:1
position: 196668
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196332-196668:1:region

YML039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML039W
so part of: sequence
location: <196628..>201896
location: region:196628-201896:1
so has part: feature:196628-201896:1:exon
subclass of: SO_0000010

854969
type: Gene
SIO_000068: ncbigene

position:196628:1
position: 196628
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201896:1
position: 201896
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196628-201896:1:exon

YML039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML039W
product: gag-pol fusion protein
transcript id: NM_001182397.2
SIO_010081: YML039W
subclass of: SO_0000673
so part of: YML039W
location: <196628..>201896
location: region:196628-201896:1
so has part: feature:196628-201896:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196628-201896:1:exon

YML039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML039W
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDRSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YML039W
subclass of: SO_0000673
so part of: YML039W
location: join(196628..197932,197934..201896)
location: region:196628-201896:1
so has part: feature:196628-197932:1:exon
so has part: feature:197934-201896:1:exon

NP_013672.1
type: Protein
SIO_000068: ncbiprotein

S000004503
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196628-197932:1:exon

position:197932:1
position: 197932
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:197934-201896:1:exon

position:197934:1
position: 197934
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML040W
so part of: sequence
location: <196628..>197950
location: region:196628-197950:1
so has part: feature:196628-197950:1:exon
subclass of: SO_0000010

854968
type: Gene
SIO_000068: ncbigene

position:197950:1
position: 197950
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196628-197950:1:exon

YML040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML040W
product: gag protein
transcript id: NM_001182398.1
SIO_010081: YML040W
subclass of: SO_0000673
so part of: YML040W
location: <196628..>197950
location: region:196628-197950:1
so has part: feature:196628-197950:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196628-197950:1:exon

YML040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML040W
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YML040W
subclass of: SO_0000673
so part of: YML040W
location: 196628..197950
location: region:196628-197950:1
so has part: feature:196628-197950:1:exon

NP_013673.1
type: Protein
SIO_000068: ncbiprotein

S000004504
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196628-197950:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 201919..202234
location: region:201919-202234:1
so has part: feature:201919-202234:1:region

S000007106
type: SGD
SIO_000068: sgd

position:201919:1
position: 201919
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:201919-202234:1:region

YML038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YMD8
locus tag: YML038C
so part of: sequence
location: complement(<202775..>204103)
location: region:202775-204103:-1
so has part: feature:202775-204103:-1:exon
subclass of: SO_0000010

854970
type: Gene
SIO_000068: ncbigene

position:202775:-1
position: 202775
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204103:-1
position: 204103
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202775-204103:-1:exon

YML038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YMD8
locus tag: YML038C
product: Ymd8p
transcript id: NM_001182396.1
SIO_010081: YML038C
subclass of: SO_0000673
so part of: YML038C
location: complement(<202775..>204103)
location: region:202775-204103:-1
so has part: feature:202775-204103:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:202775-204103:-1:exon

YML038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YMD8
locus tag: YML038C
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]
note: Putative nucleotide sugar transporter; has similarity to Vrg4p
codon start: 1
product: Ymd8p
translation: MNRTVFLAFVFGWYFCSIALSIYNRWMFDPKDGLGIGYPVLVTTFHQATLWLLSGIYIKLRHKPVKNVLRKNNGFNWSFFLKFLLPTAVASAGDIGLSNVSFQYVPLTIYTIIKSSSIAFVLLFGCIFKLEKFHWKLALSVIIMFVGVALMVFKPSDSTSTKNDQALVIFGSFLVLASSCLSGLRWVYTQLMLRNNPIQTNTAAAVEESDGALFTENEDNVDNEPVVNLANNKMLENFGESKPHPIHTIHQLAPIMGITLLLTSLLVEKPFPGIFSSSIFRLDTSNGGVGTETTVLSIVRGIVLLILPGFAVFLLTICEFSILEQTPVLTVSIVGIVKELLTVIFGIIILSERLSGFYNWLGMLIIMADVCYYNYFRYKQDLLQKYHSVSTQDNRNELKGFQDFEQLGSKKIAPYSISVDLTNQEYELDMIAQNVSRSSQQV
SIO_010081: YML038C
subclass of: SO_0000673
so part of: YML038C
location: complement(202775..204103)
location: region:202775-204103:-1
so has part: feature:202775-204103:-1:exon

NP_013674.1
type: Protein
SIO_000068: ncbiprotein

S000004502
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202775-204103:-1:exon

YML037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML037C
so part of: sequence
location: complement(<204386..>205408)
location: region:204386-205408:-1
so has part: feature:204386-205408:-1:exon
subclass of: SO_0000010

854971
type: Gene
SIO_000068: ncbigene

position:204386:-1
position: 204386
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:205408:-1
position: 205408
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204386-205408:-1:exon

YML037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML037C
product: uncharacterized protein
transcript id: NM_001182395.1
SIO_010081: YML037C
subclass of: SO_0000673
so part of: YML037C
location: complement(<204386..>205408)
location: region:204386-205408:-1
so has part: feature:204386-205408:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:204386-205408:-1:exon

YML037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML037C
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
note: hypothetical protein; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MDENKIIDQLFSKEYTPQDDSEQAKNGDVSLYGLLDEVANGRRLMNCLFHSPMQMGNKLSTDKLDGKCRQIQRDWIDEEKTITMNSGALQLDGPVLFSWSHNVAPTSHQETINTTFKQGSPSRGSNKPKITTTSQLFDRASAEIDKCIKPNSKSWMVEERFERNEAHTADGKKPSTWANSDFKVDPLQKFVVKELPKEKKKSDGDKTKKNKSKRKSFFGFWGHSGSKSGSKKKSEKPIEAKNEIQDEVSQKSGLSPDDDTTFSDKNTIQSKQESMSDQQAEPKVHEPAVTNTGCSEHDDGDGFEQVPAQSSYHPSSEPSIASTPSLTLDSFIPLQPKKKI
SIO_010081: YML037C
subclass of: SO_0000673
so part of: YML037C
location: complement(204386..205408)
location: region:204386-205408:-1
so has part: feature:204386-205408:-1:exon

NP_013675.1
type: Protein
SIO_000068: ncbiprotein

S000004501
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:204386-205408:-1:exon

YML036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CGI121
locus tag: YML036W
so part of: sequence
location: <205642..>206293
location: region:205642-206293:1
so has part: feature:205642-206293:1:exon
subclass of: SO_0000010

854972
type: Gene
SIO_000068: ncbigene

position:205642:1
position: 205642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:206293:1
position: 206293
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205642-206293:1:exon

YML036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CGI121
locus tag: YML036W
product: Cgi121p
transcript id: NM_001182394.1
SIO_010081: YML036W
subclass of: SO_0000673
so part of: YML036W
location: join(<205642..206097,206204..>206293)
location: region:205642-206293:1
so has part: feature:205642-206097:1:exon
so has part: feature:206204-206293:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:205642-206097:1:exon

position:206097:1
position: 206097
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:206204-206293:1:exon

position:206204:1
position: 206204
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CGI121
locus tag: YML036W
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:33277478]
experiment: EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16564010|PMID:16874308]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:16564010]
experiment: EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:33277478]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:25822194]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16564010]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]
experiment: EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]
note: Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; ortholog of human TPRKB
codon start: 1
product: Cgi121p
translation: MVVSIIPQFPDIKVSLALFEQVKNAKEIRSKMSELSTSFAFIDPRLVCSGEQMYSAIYKTLIEVKYNKMRTRNLNSECVLCLSPTSNISDAFLKFGIKDDSSQLICLKFHTNTDDVDKEQLRTIMTSIVKGQEIEFNDDNLSRFYDEALIRKIYKLSDDFKPQDVNGLSRALVDAIQLRGV
SIO_010081: YML036W
subclass of: SO_0000673
so part of: YML036W
location: join(205642..206097,206204..206293)
location: region:205642-206293:1
so has part: feature:205642-206097:1:exon
so has part: feature:206204-206293:1:exon

NP_013676.2
type: Protein
SIO_000068: ncbiprotein

S000004500
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205642-206097:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:206204-206293:1:exon

YML035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AMD3
gene: AMD1
locus tag: YML035C
gene synonym: AMD3
so part of: sequence
location: complement(<206428..>208860)
location: region:206428-208860:-1
so has part: feature:206428-208860:-1:exon
subclass of: SO_0000010

854973
type: Gene
SIO_000068: ncbigene

position:206428:-1
position: 206428
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:208860:-1
position: 208860
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:206428-208860:-1:exon

YML035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AMD3
gene: AMD1
locus tag: YML035C
gene synonym: AMD3
product: AMP deaminase
transcript id: NM_001182392.1
SIO_010081: YML035C
subclass of: SO_0000673
so part of: YML035C
location: complement(<206428..>208860)
location: region:206428-208860:-1
so has part: feature:206428-208860:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:206428-208860:-1:exon

YML035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AMD3
gene: AMD1
locus tag: YML035C
gene synonym: AMD3
EC number: 3.5.4.6
experiment: EXISTENCE:direct assay:GO:0003876 AMP deaminase activity [PMID:2690949]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006163 purine nucleotide metabolic process [PMID:15869715|PMID:18433446|PMID:19635936]
experiment: EXISTENCE:genetic interaction:GO:0006178 guanine salvage [PMID:19635936]
experiment: EXISTENCE:mutant phenotype:GO:0003876 AMP deaminase activity [PMID:2690949]
experiment: EXISTENCE:mutant phenotype:GO:0006163 purine nucleotide metabolic process [PMID:19635936|PMID:20087341]
experiment: EXISTENCE:mutant phenotype:GO:0006178 guanine salvage [PMID:19635936]
note: AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
codon start: 1
product: AMP deaminase
translation: MDNQATQRLNDLSLEPAPSHDEQDGSGLVIDIDQRKIGDEQAGVVVDDETPPLEQQDSHESLAADSRNANFSYHENQQLLENGTKQLALDEHDSHSAILEQPSHSTNCSSSNIAAMNKGHDSADHASQNSGGKPRTLSASAQHILPETLKSFAGAPVVNKQVRTSASYKMGMLADDASQQFLDDPSSELIDLYSKVAECRNLRAKYQTISVQNDDQNPKNKPGWVVYPPPPKPSYNSDTKTVVPVTNKPDAEVFDFTKCEIPGEDPDWEFTLNDDDSYVVHRSGKTDELIAQIPTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELVNHFANFKRTIEEK
SIO_010081: YML035C
subclass of: SO_0000673
so part of: YML035C
location: complement(206428..208860)
location: region:206428-208860:-1
so has part: feature:206428-208860:-1:exon

NP_013677.1
type: Protein
SIO_000068: ncbiprotein

S000004498
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:206428-208860:-1:exon

YML034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEH1
alternative label: YML033W
gene: SRC1
locus tag: YML034W
gene synonym: HEH1; YML033W
so part of: sequence
location: <209525..>212155
location: region:209525-212155:1
so has part: feature:209525-212155:1:exon
subclass of: SO_0000010

854974
type: Gene
SIO_000068: ncbigene

position:209525:1
position: 209525
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212155:1
position: 212155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:209525-212155:1:exon

YML034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEH1
alternative label: YML033W
gene: SRC1
locus tag: YML034W
gene synonym: HEH1; YML033W
product: Src1p
transcript id: NM_001182391.1
SIO_010081: YML034W
subclass of: SO_0000673
so part of: YML034W
location: join(<209525..211444,211571..>212155)
location: region:209525-212155:1
so has part: feature:209525-211444:1:exon
so has part: feature:211571-212155:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:209525-211444:1:exon

position:211444:1
position: 211444
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:211571-212155:1:exon

position:211571:1
position: 211571
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEH1
alternative label: YML033W
gene: SRC1
locus tag: YML034W
gene synonym: HEH1; YML033W
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:18762579]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:16929305]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:11754482]
experiment: EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:11754482]
experiment: EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:18997772]
note: Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication
codon start: 1
product: Src1p
translation: MNSDLEYLEDGFDPNSMKVATLRRILVENNVDFPSNARKNALVGLFDEKVKPQIPQLRKMYLNVRPSDEGIVKMDRPSSSPSIASPRRSRRARREKSASPMAKQFKKNRILDDVSNDDDDDDDDDDDNDKKDDPLIVPSGTDTDEVDDEEDDVITSSSNKSDTNDFQQNSDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDLNQEHGNGSAILGKLSVKTPIKNTNRKPVSMDNFNDSLTSSGTENDPFVPNIRHNPKELGTANGTGHSTPLSKLKVSASFADKLPQKEVPSTILVPEVEQQEPSQSERTPSLFSSEGSGSESEAPLLPEITTPGPHQPMGNTSNNVVEMIDTDSSNLVSDEDEVLVPTRIETPQLPTEKDVEKCEARVQELQEEVNEQLEHENGSEFDVKQGSGKVGNRHKFKRALKFLSKSLLALFLFCIFIVIPLLFGLWYREQRLLIGYCGHEVPSHRVSGNSFEFIQKLDNLLQDYRPKCIPCPPNGICYPYLKLKCKPDYKLAPSRLDFLEIIPAQGKCVKDDKKQQLVSEVVEKSLEFLRAKNAQISCGDGKDDIESGMTEDALYQIFNEARAPWIRDDEFEDLWIQVIKDLTEEPEILWRQLSPTDNNIGGNSNNIIKTNDVPRQKRHLPEKFISKTRNFRSTSKKYIGMKCRFEREIYQTYKKFQRPIWLMFLLIVISKVIEIKLKNYYRKKARIEELVTQTMEKLKFQKIKSMSDPKENAYLSIVQLRDIFLSDIVDLKYKNQLWSEVVKYLEHNNSNIKSNLTEIRGEIMKCWEWIGPMELNEPKDSAENKI
SIO_010081: YML034W
subclass of: SO_0000673
so part of: YML034W
location: join(209525..211444,211571..212155)
location: region:209525-212155:1
so has part: feature:209525-211444:1:exon
so has part: feature:211571-212155:1:exon

NP_013679.1
type: Protein
SIO_000068: ncbiprotein

S000004497
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:209525-211444:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:211571-212155:1:exon

YML032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD52
locus tag: YML032C
so part of: sequence
location: complement(<212515..>213930)
location: region:212515-213930:-1
so has part: feature:212515-213930:-1:exon
subclass of: SO_0000010

854976
type: Gene
SIO_000068: ncbigene

position:212515:-1
position: 212515
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:213930:-1
position: 213930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212515-213930:-1:exon

YML032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD52
locus tag: YML032C
product: recombinase RAD52
transcript id: NM_001182390.1
SIO_010081: YML032C
subclass of: SO_0000673
so part of: YML032C
location: complement(<212515..>213930)
location: region:212515-213930:-1
so has part: feature:212515-213930:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212515-213930:-1:exon

YML032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD52
locus tag: YML032C
experiment: EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:15205482]
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:12766777]
experiment: EXISTENCE:direct assay:GO:0000730 DNA recombinase assembly [PMID:11459983]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11459964|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:1904877 positive regulation of DNA ligase activity [PMID:32083180]
experiment: EXISTENCE:direct assay:GO:1990814 DNA/DNA annealing activity [PMID:27362509]
experiment: EXISTENCE:genetic interaction:GO:0000709 meiotic joint molecule formation [PMID:18313389]
experiment: EXISTENCE:genetic interaction:GO:0045002 double-strand break repair via single-strand annealing [PMID:11606529]
experiment: EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:18313389]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918|PMID:25822194]
experiment: EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17096599|PMID:24190138]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17096599]
experiment: EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]
experiment: EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:7038396]
experiment: EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]
experiment: EXISTENCE:mutant phenotype:GO:1904877 positive regulation of DNA ligase activity [PMID:32083180]
note: Protein involved in homologous recombination; attenuates resection of DNA double-strand break ends and stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination; phosphorylation by Cdc28p in G2/M phase promotes Rad52p ring interaction that leads to superstructure formation
codon start: 1
product: recombinase RAD52
translation: MNEIMDMDEKKPVFGNHSEDIQTKLDKKLGPEYISKRVGFGTSRIAYIEGWRVINLANQIFGYNGWSTEVKSVVIDFLDERQGKFSIGCTAIVRVTLTSGTYREDIGYGTVENERRKPAAFERAKKSAVTDALKRSLRGFGNALGNCLYDKDFLAKIDKVKFDPPDFDENNLFRPTDEISESSRTNTLHENQEQQQYPNKRRQLTKVTNTNPDSTKNLVKIENTVSRGTPMMAAPAEANSKNSSNKDTDLKSLDASKQDQDDLLDDSLMFSDDFQDDDLINMGNTNSNVLTTEKDPVVAKQSPTASSNPEAEQITFVTAKAATSVQNERYIGEESIFDPKYQAQSIRHTVDQTTSKHIPASVLKDKTMTTARDSVYEKFAPKGKQLSMKNNDKELGPHMLEGAGNQVPRETTPIKTNATAFPPAAAPRFAPPSKVVHPNGNGAVPAVPQQRSTRREVGRPKINPLHARKPT
SIO_010081: YML032C
subclass of: SO_0000673
so part of: YML032C
location: complement(212515..213930)
location: region:212515-213930:-1
so has part: feature:212515-213930:-1:exon

NP_013680.2
type: Protein
SIO_000068: ncbiprotein

S000004494
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212515-213930:-1:exon

YML031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NDC1
locus tag: YML031W
so part of: sequence
location: <214189..>216156
location: region:214189-216156:1
so has part: feature:214189-216156:1:exon
subclass of: SO_0000010

854977
type: Gene
SIO_000068: ncbigene

position:214189:1
position: 214189
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:216156:1
position: 216156
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214189-216156:1:exon

YML031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NDC1
locus tag: YML031W
product: Ndc1p
transcript id: NM_001182389.1
SIO_010081: YML031W
subclass of: SO_0000673
so part of: YML031W
location: <214189..>216156
location: region:214189-216156:1
so has part: feature:214189-216156:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214189-216156:1:exon

YML031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NDC1
locus tag: YML031W
experiment: EXISTENCE:curator inference:GO:0006913 nucleocytoplasmic transport [PMID:9864355]
experiment: EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:9864355]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:9864355]
experiment: EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:10684247|PMID:19414609]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:15075274|PMID:16682526]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16682526]
experiment: EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:15075274|PMID:16682526]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:15075274|PMID:8349727]
experiment: EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]
note: Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
codon start: 1
product: Ndc1p
translation: MIQTPRELLNPRYTYHTIFSDVCKTRFNHLVTRLFFICSIIQTVVISLLALPHSPLWELALAFIPNILALNLVSLLIIVTRKNYMHVKNFGFANSLTFILGQLLSVKFLVYQGVYSMGSILLSFVLGVVFGRGGSGWKPYYKLFIWLVVPTIYNLQHHVTDADKLSFNCENFFQAPQDYVLERVKRIMEKSVILSVISMFVLPIFTTVFFSRQKSGLFDSFTNGVLAVTNLLIISCIIFITFEFINIAFDAHMSIGCLHKGKLISNLSSTPMETLLSGLSADKPFTRLTAYQELAYRATSLDPSLRAPIYHSKFRSSSGNTWSLILNECLKTIQINNEKVVQYLRSVQDLGGSATARHKKKVENLDYMYENGKLTSANERLFGNRPSMMAPLRDNGLLDESPNRLRVRTDDSVLLNRGNKKRHRSSYYDNDLDETTQTFNGSIFTHETTFMTAMRLMLKKLKNSIMSFIFPSYAERQSSDESDNYRLLPNGSNKAQISIIDIWSISKKRQAEKLVPLPICHANSVVALTGLLIRSKTEDPKGGIIASVGDILKTLERSICALGEFADWDPESMAYTAFQTQRTAQDRVQQDSEDEDSMKDTTDMISVLYQLSTSAFMEIVLEYNVALNDVYLDADVAKLANWFLEVYASGNPNAT
SIO_010081: YML031W
subclass of: SO_0000673
so part of: YML031W
location: 214189..216156
location: region:214189-216156:1
so has part: feature:214189-216156:1:exon

NP_013681.1
type: Protein
SIO_000068: ncbiprotein

S000004493
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214189-216156:1:exon

YML030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM31
gene: RCF1
locus tag: YML030W
gene synonym: AIM31
so part of: sequence
location: <216435..>216914
location: region:216435-216914:1
so has part: feature:216435-216914:1:exon
subclass of: SO_0000010

854978
type: Gene
SIO_000068: ncbigene

position:216435:1
position: 216435
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:216914:1
position: 216914
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:216435-216914:1:exon

YML030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM31
gene: RCF1
locus tag: YML030W
gene synonym: AIM31
product: Rcf1p
transcript id: NM_001182388.1
SIO_010081: YML030W
subclass of: SO_0000673
so part of: YML030W
location: <216435..>216914
location: region:216435-216914:1
so has part: feature:216435-216914:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:216435-216914:1:exon

YML030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM31
gene: RCF1
locus tag: YML030W
gene synonym: AIM31
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24478450|PMID:14562095|PMID:14576278|PMID:16823961|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22405070|PMID:22310663|PMID:22342701]
experiment: EXISTENCE:direct assay:GO:0005746 mitochondrial respirasome [PMID:22405070|PMID:22310663|PMID:22342701]
experiment: EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:22310663]
experiment: EXISTENCE:mutant phenotype:GO:0010155 regulation of proton transport [PMID:31591265]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:29746825]
experiment: EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:22405070|PMID:22342701]
note: Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
codon start: 1
product: Rcf1p
translation: MSRMPSSFDVTERDLDDMTFGERIIYHCKKQPLVPIGCLLTTGAVILAAQNVRLGNKWKAQYYFRWRVGLQAATLVALVAGSFIYGTSGKELKAKEEQLKEKAKMREKLWIQELERREEETEARRKRAELARMKTLENEEEIKNLEKELSDLENKLGKK
SIO_010081: YML030W
subclass of: SO_0000673
so part of: YML030W
location: 216435..216914
location: region:216435-216914:1
so has part: feature:216435-216914:1:exon

NP_013682.1
type: Protein
SIO_000068: ncbiprotein

S000004492
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:216435-216914:1:exon

YML029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: USA1
locus tag: YML029W
so part of: sequence
location: <217362..>219878
location: region:217362-219878:1
so has part: feature:217362-219878:1:exon
subclass of: SO_0000010

854979
type: Gene
SIO_000068: ncbigene

position:217362:1
position: 217362
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:219878:1
position: 219878
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217362-219878:1:exon

YML029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: USA1
locus tag: YML029W
product: Usa1p
transcript id: NM_001182387.1
SIO_010081: YML029W
subclass of: SO_0000673
so part of: YML029W
location: <217362..>219878
location: region:217362-219878:1
so has part: feature:217362-219878:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217362-219878:1:exon

YML029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: USA1
locus tag: YML029W
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:20005842]
experiment: EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:31713515]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16873066]
experiment: EXISTENCE:mutant phenotype:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16873066]
experiment: EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:11425851]
experiment: EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:16873066]
experiment: EXISTENCE:physical interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16873066]
note: Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
codon start: 1
product: Usa1p
translation: MSEYLAQTPCKFTIWSSEIDLIRTNLLVNAHPLSTVGRLLQYIHYQIYKQLRAIYQPEEQCTNSEIPHTPLNSINTYFLSYEGRELSATCLLKDITSSSHPDSNHFIRLQLEKRTSPSGSAFDLEYDMEGEFNSMNIQFEINTLSSQRIFNSMEPNLPIGTTLARLEKLALERIKDFEKSAGNLCGIKEDHSVSDLQGFIIKGKQTPMFLNYGSDSDYYKDLNLVDLIGIDFAPAHNSFFTFLFKMNHEQNSHIANDEERFVLEFISDATLSITQMNVKPDTTVKQVKDFICSVYTHSLNLRRNDIKLIYKGQLLHENNFAGNSSKISEYIKEPHEVKVHVQINQEYTESGPGFWNEVFNNPNIFQFMPPDTRSQSPVSFAPTQGRSPAAIRGEERGIPYVTESGNDIVPTDELYRKCIINGDEVVFIPVSELNPQSSYLSVIKGDYGEIKIPISSNDYRINGDNILLSPSAIEQLESALNFKIERPRDSTLLHPSGEHVRAADNTSSANDNNTVENDESAWNRRVVRPLRNSFPLLLVLIRTFYLIGYNSLVPFFIILEFGSFLPWKYIILLSLLFIFRTVWNTQEVWNLWRDYLHLNEIDEVKFSQIKEFINSNSLTLNFYKKCKDTQSAIDLLMIPNLHEQRLSVYSKYDIEYDTNTPDVGQLNLLFIKVLSGEIPKDALDELFKEFFELYETTRNMNTLYPQDSLNELLLMIWKESQKKDINTLPKYRRWFQTLCSQIAEHNVLDVVLRYIIPDPVNDRVITAVIKNFVLFWVTLLPYVKEKLDDIVAQRARDREQPAPSAQQQENEDEALIIPDEEEPTATGAQPHLYIPDED
SIO_010081: YML029W
subclass of: SO_0000673
so part of: YML029W
location: 217362..219878
location: region:217362-219878:1
so has part: feature:217362-219878:1:exon

NP_013683.1
type: Protein
SIO_000068: ncbiprotein

S000004491
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217362-219878:1:exon

YML028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TPX1
alternative label: ZRG14
gene: TSA1
locus tag: YML028W
gene synonym: TPX1; ZRG14
so part of: sequence
location: <220138..>220728
location: region:220138-220728:1
so has part: feature:220138-220728:1:exon
subclass of: SO_0000010

854980
type: Gene
SIO_000068: ncbigene

position:220138:1
position: 220138
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220728:1
position: 220728
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220138-220728:1:exon

YML028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TPX1
alternative label: ZRG14
gene: TSA1
locus tag: YML028W
gene synonym: TPX1; ZRG14
product: thioredoxin peroxidase TSA1
transcript id: NM_001182386.1
SIO_010081: YML028W
subclass of: SO_0000673
so part of: YML028W
location: <220138..>220728
location: region:220138-220728:1
so has part: feature:220138-220728:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220138-220728:1:exon

YML028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TPX1
alternative label: ZRG14
gene: TSA1
locus tag: YML028W
gene synonym: TPX1; ZRG14
EC number: 1.11.1.24
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10681558|PMID:8344960|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18271751]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:18271751]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:15163410]
experiment: EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:7961686|PMID:9799566]
experiment: EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:8344960]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:18271751]
experiment: EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:8344960]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:15163410]
experiment: EXISTENCE:direct assay:GO:0051920 peroxiredoxin activity [PMID:17210445]
experiment: EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:19851444]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]
experiment: EXISTENCE:mutant phenotype:GO:0006111 regulation of gluconeogenesis [PMID:27634403]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:16251355]
experiment: EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:7961686|PMID:9799566]
experiment: EXISTENCE:mutant phenotype:GO:0019207 kinase regulator activity [PMID:27634403]
experiment: EXISTENCE:mutant phenotype:GO:0033194 response to hydroperoxide [PMID:15210711]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18271751|PMID:8344960]
experiment: EXISTENCE:mutant phenotype:GO:0042262 DNA protection [PMID:19543365]
experiment: EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:9799566|PMID:8344960]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16251355]
experiment: EXISTENCE:mutant phenotype:GO:0061077 chaperone-mediated protein folding [PMID:24022485]
note: Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form a HMW chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; hydrogen peroxide receptor and signal transducer in a light sensing pathway; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases and forms cytoplasmic foci during DNA replication stress
codon start: 1
product: thioredoxin peroxidase TSA1
translation: MVAQVQKQAPTFKKTAVVDGVFDEVSLDKYKGKYVVLAFIPLAFTFVCPTEIIAFSEAAKKFEEQGAQVLFASTDSEYSLLAWTNIPRKEGGLGPINIPLLADTNHSLSRDYGVLIEEEGVALRGLFIIDPKGVIRHITINDLPVGRNVDEALRLVEAFQWTDKNGTVLPCNWTPGAATIKPTVEDSKEYFEAANK
SIO_010081: YML028W
subclass of: SO_0000673
so part of: YML028W
location: 220138..220728
location: region:220138-220728:1
so has part: feature:220138-220728:1:exon

NP_013684.1
type: Protein
SIO_000068: ncbiprotein

S000004490
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220138-220728:1:exon

YML027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YOX1
locus tag: YML027W
so part of: sequence
location: <221406..>222563
location: region:221406-222563:1
so has part: feature:221406-222563:1:exon
subclass of: SO_0000010

854981
type: Gene
SIO_000068: ncbigene

position:221406:1
position: 221406
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222563:1
position: 222563
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221406-222563:1:exon

YML027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YOX1
locus tag: YML027W
product: Yox1p
transcript id: NM_001182385.1
SIO_010081: YML027W
subclass of: SO_0000673
so part of: YML027W
location: <221406..>222563
location: region:221406-222563:1
so has part: feature:221406-222563:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221406-222563:1:exon

YML027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YOX1
locus tag: YML027W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]
experiment: EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:20385087|PMID:12464633]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:genetic interaction:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:12464633]
experiment: EXISTENCE:mutant phenotype:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:12464633]
experiment: EXISTENCE:mutant phenotype:GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:12464633|PMID:17314407]
note: Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication
codon start: 1
product: Yox1p
translation: MSQETKMLPSLSSLLSGTEISSSPVSPSFTNPRTSFHLDDRGTIKLPPLNTSINRPRSVESALRHTVTSLHENSSAYGDDMLKHTQSDSALSSQLNSSQETVDESHENLLLTPLNSKKRDYSVSSKKNDILTPLSAAKSIIIPSASKEKRRAFAFITHSQETFPKKEPKIDNAPLARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQRIATSKSTTIIQTVSPPSPPLDVHATPLASRVKADILRDGSSCSRSSSSSPLENTPPRPHHSLNRRSSTPSIKRSQALTFHLNPQKKTLTPVKTSPNSRVNKLINSIDHSPSKAKRPVSNPSGSPKRKRKFGFKIVDQQPLKDLDPNAFRG
SIO_010081: YML027W
subclass of: SO_0000673
so part of: YML027W
location: 221406..222563
location: region:221406-222563:1
so has part: feature:221406-222563:1:exon

NP_013685.1
type: Protein
SIO_000068: ncbiprotein

S000004489
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221406-222563:1:exon

YML026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS18B
locus tag: YML026C
so part of: sequence
location: complement(<222987..>223828)
location: region:222987-223828:-1
so has part: feature:222987-223828:-1:exon
subclass of: SO_0000010

854982
type: Gene
SIO_000068: ncbigene

position:222987:-1
position: 222987
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:223828:-1
position: 223828
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222987-223828:-1:exon

YML026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS18B
locus tag: YML026C
product: ribosomal 40S subunit protein S18B
transcript id: NM_001182384.1
SIO_010081: YML026C
subclass of: SO_0000673
so part of: YML026C
location: complement(join(<222987..223380,223782..>223828))
location: region:222987-223828:-1
so has part: feature:223782-223828:-1:exon
so has part: feature:222987-223380:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:223782-223828:-1:exon

position:223782:-1
position: 223782
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:222987-223380:-1:exon

position:223380:-1
position: 223380
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS18B
locus tag: YML026C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: ribosomal 40S subunit protein S18B
translation: MSLVVQEQGSFQHILRLLNTNVDGNIKIVYALTTIKGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVQIMQNPTHYKIPAWFLNRQNDITDGKDYHTLANNVESKLRDDLERLKKIRAHRGIRHFWGLRVRGQHTKTTGRRRA
SIO_010081: YML026C
subclass of: SO_0000673
so part of: YML026C
location: complement(join(222987..223380,223782..223828))
location: region:222987-223828:-1
so has part: feature:223782-223828:-1:exon
so has part: feature:222987-223380:-1:exon

NP_013686.1
type: Protein
SIO_000068: ncbiprotein

S000004488
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:223782-223828:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:222987-223380:-1:exon

YML025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL4m
gene: YML6
locus tag: YML025C
gene synonym: uL4m
so part of: sequence
location: complement(<224406..>225365)
location: region:224406-225365:-1
so has part: feature:224406-225365:-1:exon
subclass of: SO_0000010

854983
type: Gene
SIO_000068: ncbigene

position:224406:-1
position: 224406
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225365:-1
position: 225365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224406-225365:-1:exon

YML025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL4m
gene: YML6
locus tag: YML025C
gene synonym: uL4m
product: mitochondrial 54S ribosomal protein YmL6
transcript id: NM_001182383.1
SIO_010081: YML025C
subclass of: SO_0000673
so part of: YML025C
location: complement(join(<224406..225239,225339..>225365))
location: region:224406-225365:-1
so has part: feature:225339-225365:-1:exon
so has part: feature:224406-225239:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225339-225365:-1:exon

position:225339:-1
position: 225339
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:224406-225239:-1:exon

position:225239:-1
position: 225239
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YML025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL4m
gene: YML6
locus tag: YML025C
gene synonym: uL4m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
codon start: 1
product: mitochondrial 54S ribosomal protein YmL6
translation: MTIKRNLVKTLQSIRYQATTATAHAESTLNPLPNAAIPPKYALVTVRSFPSLEPLTFVPVPTSTVAAPLRRDILWRAVVYENDNRRVGASNPPGRSENGFSRRKLMPQKGSGRARVGDANSPTRHNGGRALARTAPNDYTTELPSKVYSMAFNNALSHQYKSGKLFVIGGEKVDLISPTPELDLNRLDLVNTNTVEGKEIFEGEVIFRKFLEEFQLKGKRLLFITDKTREGLIKSSDPYKQKVDVIQKELVEVNDILRAQAVFIELEALEYLAMAHQKEILHSVSN
SIO_010081: YML025C
subclass of: SO_0000673
so part of: YML025C
location: complement(join(224406..225239,225339..225365))
location: region:224406-225365:-1
so has part: feature:225339-225365:-1:exon
so has part: feature:224406-225239:-1:exon

NP_013687.1
type: Protein
SIO_000068: ncbiprotein

S000004487
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225339-225365:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:224406-225239:-1:exon

YML024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RP51A
alternative label: RPL51A
gene: RPS17A
locus tag: YML024W
gene synonym: RP51A; RPL51A
so part of: sequence
location: <225889..>226697
location: region:225889-226697:1
so has part: feature:225889-226697:1:exon
subclass of: SO_0000010

854984
type: Gene
SIO_000068: ncbigene

position:225889:1
position: 225889
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:226697:1
position: 226697
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:225889-226697:1:exon

YML024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RP51A
alternative label: RPL51A
gene: RPS17A
locus tag: YML024W
gene synonym: RP51A; RPL51A
product: ribosomal 40S subunit protein S17A
transcript id: NM_001182382.1
SIO_010081: YML024W
subclass of: SO_0000673
so part of: YML024W
location: join(<225889..225891,226290..>226697)
location: region:225889-226697:1
so has part: feature:225889-225891:1:exon
so has part: feature:226290-226697:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225889-225891:1:exon

position:225891:1
position: 225891
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:226290-226697:1:exon

position:226290:1
position: 226290
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RP51A
alternative label: RPL51A
gene: RPS17A
locus tag: YML024W
gene synonym: RP51A; RPL51A
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:3915776]
note: Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S17A
translation: MGRVRTKTVKRASKALIERYYPKLTLDFQTNKRLCDEIATIQSKRLRNKIAGYTTHLMKRIQKGPVRGISFKLQEEERERKDQYVPEVSALDLSRSNGVLNVDNQTSDLVKSLGLKLPLSVINVSAQRDRRYRKRV
SIO_010081: YML024W
subclass of: SO_0000673
so part of: YML024W
location: join(225889..225891,226290..226697)
location: region:225889-226697:1
so has part: feature:225889-225891:1:exon
so has part: feature:226290-226697:1:exon

NP_013688.1
type: Protein
SIO_000068: ncbiprotein

S000004486
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225889-225891:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:226290-226697:1:exon

YML023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSE5
locus tag: YML023C
so part of: sequence
location: complement(<226994..>228664)
location: region:226994-228664:-1
so has part: feature:226994-228664:-1:exon
subclass of: SO_0000010

854985
type: Gene
SIO_000068: ncbigene

position:226994:-1
position: 226994
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228664:-1
position: 228664
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226994-228664:-1:exon

YML023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSE5
locus tag: YML023C
product: Smc5-Smc6 complex subunit NSE5
transcript id: NM_001182381.1
SIO_010081: YML023C
subclass of: SO_0000673
so part of: YML023C
location: complement(<226994..>228664)
location: region:226994-228664:-1
so has part: feature:226994-228664:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:226994-228664:-1:exon

YML023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSE5
locus tag: YML023C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:34191293]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]
note: Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
codon start: 1
product: Smc5-Smc6 complex subunit NSE5
translation: MDGALINSVLYVSPRNGAHYFVELTEKHLLAFEMLNSMCLLENYDHVLLFLECQFGKSHNLAVIPFDIILVLFTLSTLSEYYKEPILRANDPYNTSRETLSRRALKLLQKYLAILKEFDSEQYNLYDLELLRCQFFLAIDTLTPKKQKWGFDRFRRTKSESGVTYRQNASVDPELDQAKTFKNPYRSYISCLEQRNTILGNRLLNLKLNEPGEFINMILWTLSNSLQESTPLFLSSHEIWMPLLEILIDLFSCRQDYFIQHEVAQNVSKSLFVQRLSESPLAVFFESLNTRNFANRFSEYVFLNCDYKLPSDNYATPVHPVYNGENTIVDTYIPTIKCSPLYKSQKSLALRRKLIGSCFKLLLRVPDGHRLITPRIVADDVIQGISRTLASFNDILQFKKFFMTENLSQESYFIPLLAEGTLSEILKDTQECVVILTLVENLSDGVSFCNEVIGLVKSKCFAFTEQCSQASYEEAVLNIEKCDVCLLVLLRYLLHLIGTEAILDAKEQLEMLHAIEKNDSGRRQWAKALNLGNDPPLLYPIVSQMFGVHDKSVIIE
SIO_010081: YML023C
subclass of: SO_0000673
so part of: YML023C
location: complement(226994..228664)
location: region:226994-228664:-1
so has part: feature:226994-228664:-1:exon

NP_013689.1
type: Protein
SIO_000068: ncbiprotein

S000004485
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:226994-228664:-1:exon

YML022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APT1
locus tag: YML022W
so part of: sequence
location: <228937..>229500
location: region:228937-229500:1
so has part: feature:228937-229500:1:exon
subclass of: SO_0000010

854986
type: Gene
SIO_000068: ncbigene

position:228937:1
position: 228937
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229500:1
position: 229500
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228937-229500:1:exon

YML022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APT1
locus tag: YML022W
product: adenine phosphoribosyltransferase APT1
transcript id: NM_001182380.1
SIO_010081: YML022W
subclass of: SO_0000673
so part of: YML022W
location: <228937..>229500
location: region:228937-229500:1
so has part: feature:228937-229500:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228937-229500:1:exon

YML022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APT1
locus tag: YML022W
EC number: 2.4.2.7
experiment: EXISTENCE:direct assay:GO:0003999 adenine phosphoribosyltransferase activity [PMID:9864350]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006168 adenine salvage [PMID:9864350]
note: Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication
codon start: 1
product: adenine phosphoribosyltransferase APT1
translation: MSIASYAQELKLALHQYPNFPSEGILFEDFLPIFRNPGLFQKLIDAFKLHLEEAFPEVKIDYIVGLESRGFLFGPTLALALGVGFVPVRKAGKLPGECFKATYEKEYGSDLFEIQKNAIPAGSNVIIVDDIIATGGSAAAAGELVEQLEANLLEYNFVMELDFLKGRSKLNAPVFTLLNAQKEALKK
SIO_010081: YML022W
subclass of: SO_0000673
so part of: YML022W
location: 228937..229500
location: region:228937-229500:1
so has part: feature:228937-229500:1:exon

NP_013690.1
type: Protein
SIO_000068: ncbiprotein

S000004484
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228937-229500:1:exon

YML021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UNG1
locus tag: YML021C
so part of: sequence
location: complement(<229734..>230813)
location: region:229734-230813:-1
so has part: feature:229734-230813:-1:exon
subclass of: SO_0000010

854987
type: Gene
SIO_000068: ncbigene

position:229734:-1
position: 229734
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:230813:-1
position: 230813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229734-230813:-1:exon

YML021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UNG1
locus tag: YML021C
product: uracil-DNA glycosylase
transcript id: NM_001182379.1
SIO_010081: YML021C
subclass of: SO_0000673
so part of: YML021C
location: complement(<229734..>230813)
location: region:229734-230813:-1
so has part: feature:229734-230813:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229734-230813:-1:exon

YML021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UNG1
locus tag: YML021C
EC number: 3.2.2.27
experiment: EXISTENCE:direct assay:GO:0004844 uracil DNA N-glycosylase activity [PMID:2644266]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11812822|PMID:24034606]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11812822|PMID:24034606]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1938887]
note: Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus
codon start: 1
product: uracil-DNA glycosylase
translation: MWCMRRLPTNSVMTVARKRKQTTIEDFFGTKKSTNEAPNKKGKSGATFMTITNGAAIKTETKAVAKEANTDKYPANSNAKDVYSKNLSSNLRTLLSLELETIDDSWFPHLMDEFKKPYFVKLKQFVTKEQADHTVFPPAKDIYSWTRLTPFNKVKVVIIGQDPYHNFNQAHGLAFSVKPPTPAPPSLKNIYKELKQEYPDFVEDNKVGDLTHWASQGVLLLNTSLTVRAHNANSHSKHGWETFTKRVVQLLIQDREADGKSLVFLLWGNNAIKLVESLLGSTSVGSGSKYPNIMVMKSVHPSPLSASRGFFGTNHFKMINDWLYNTRGEKMIDWSVVPGTSLREVQEANARLESESKDP
SIO_010081: YML021C
subclass of: SO_0000673
so part of: YML021C
location: complement(229734..230813)
location: region:229734-230813:-1
so has part: feature:229734-230813:-1:exon

NP_013691.1
type: Protein
SIO_000068: ncbiprotein

S000004483
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229734-230813:-1:exon

YML020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML020W
so part of: sequence
location: <231149..>233143
location: region:231149-233143:1
so has part: feature:231149-233143:1:exon
subclass of: SO_0000010

854988
type: Gene
SIO_000068: ncbigene

position:231149:1
position: 231149
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233143:1
position: 233143
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231149-233143:1:exon

YML020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML020W
product: uncharacterized protein
transcript id: NM_001182378.1
SIO_010081: YML020W
subclass of: SO_0000673
so part of: YML020W
location: <231149..>233143
location: region:231149-233143:1
so has part: feature:231149-233143:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:231149-233143:1:exon

YML020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML020W
codon start: 1
product: uncharacterized protein
translation: MVTTPLHSSPKSSLKSSTTSLRSVHTQSGRMGPSEPKHRTTKSWSIWGGNDEEEPELSNKNKGKETAQDNSQENDNVSNEGTRLHDNQQTTILKETTRIEKGEKDKKDRNAAIVEKNTRPRAWPFFWGRNKKDPEPTHNIPTDADNNTLSRLANSLNPAPLTNTYIPYKPDAILIRDKGVKTAKKLTDDIGNQFPNIVVPSFDILPKQTIWNTVTSTIWKWKTEYWDRRPSSRVREGEEQVQHSQNQLKEETNTVANEAKDEERLEHNRGSLFRVDPWKKINLLSDYQSRPIRVLIVGVHGFFPTKIIRPFIGEPTGTSTKFVTEAEEIVKEYFDQHKVPIEISKIALEREGEIFDRVDFFYEVMKHWSKEINNSDFIYFVSHSQGCPVTIMLLAKLIKNGIINLDNSQFFNDEIQFCSSKKIISVLAMAGINNGPFYGADQTLFVRAYQTIEKDSLRELFEFQKFDSKQSQSFIEGLRTIISNNVKITFVGSINDQLVPLYSSTCLFANHPNIFRAIFIDRGSQTPAFITRIVKIAGSLLNLGYNDHGIIKEISGSLAGTLTGGGHSTIYNEKQVYHLGIKFALETTDLSEMYPIEYSPYKLSELGANPYRLPWCMRGLMYESNKHFSNEEIKMLFKEFEEWEPETKQLKDIKNRLNGLKYRL
SIO_010081: YML020W
subclass of: SO_0000673
so part of: YML020W
location: 231149..233143
location: region:231149-233143:1
so has part: feature:231149-233143:1:exon

NP_013692.1
type: Protein
SIO_000068: ncbiprotein

S000004482
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:231149-233143:1:exon

YML019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OST6
locus tag: YML019W
so part of: sequence
location: <233457..>234455
location: region:233457-234455:1
so has part: feature:233457-234455:1:exon
subclass of: SO_0000010

854989
type: Gene
SIO_000068: ncbigene

position:233457:1
position: 233457
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:234455:1
position: 234455
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:233457-234455:1:exon

YML019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OST6
locus tag: YML019W
product: dolichyl-diphosphooligosaccharide--protein glycotransferase
transcript id: NM_001182377.1
SIO_010081: YML019W
subclass of: SO_0000673
so part of: YML019W
location: <233457..>234455
location: region:233457-234455:1
so has part: feature:233457-234455:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:233457-234455:1:exon

YML019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OST6
locus tag: YML019W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:23416356]
experiment: EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:10358084]
experiment: EXISTENCE:genetic interaction:GO:0065003 protein-containing complex assembly [PMID:10358084]
note: Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
codon start: 1
product: dolichyl-diphosphooligosaccharide--protein glycotransferase
translation: MKWCSTYIIIWLAIIFHKFQKSTATASHNIDDILQLKDDTGVITVTADNYPLLSRGVPGYFNILYITMRGTNSNGMSCQLCHDFEKTYHAVADVIRSQAPQSLNLFFTVDVNEVPQLVKDLKLQNVPHLVVYPPAESNKQSQFEWKTSPFYQYSLVPENAENTLQFGDFLAKILNISITVPQAFNVQEFVYYFVACMVVFIFIKKVILPKVTNKWKLFSMILSLGILLPSITGYKFVEMNAIPFIARDAKNRIMYFSGGSGWQFGIEIFSVSLMYIVMSALSVLLIYVPKISCVSEKMRGLLSSFLACVLFYFFSYFISCYLIKNPGYPIVF
SIO_010081: YML019W
subclass of: SO_0000673
so part of: YML019W
location: 233457..234455
location: region:233457-234455:1
so has part: feature:233457-234455:1:exon

NP_013693.1
type: Protein
SIO_000068: ncbiprotein

S000004481
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:233457-234455:1:exon

YML018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YML018C
so part of: sequence
location: complement(<234771..>235952)
location: region:234771-235952:-1
so has part: feature:234771-235952:-1:exon
subclass of: SO_0000010

854990
type: Gene
SIO_000068: ncbigene

position:234771:-1
position: 234771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235952:-1
position: 235952
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234771-235952:-1:exon

YML018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YML018C
product: uncharacterized protein
transcript id: NM_001182376.1
SIO_010081: YML018C
subclass of: SO_0000673
so part of: YML018C
location: complement(<234771..>235952)
location: region:234771-235952:-1
so has part: feature:234771-235952:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234771-235952:-1:exon

YML018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YML018C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:22842922|PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MVSKDQTSFNKRWTLGLLMLGLVIILWVLSSFLINLIFEDDSYRKPFFITYTNTAAFIFYLFPTAKAVVVNYKDTGRANVHRELIMEEEGTGSDSNRSVDMTSPLLTNLEAGTHANQKKRLTLYETIKLSAEFCILWFTANLVTNASLAFTSVASQTILSTTSSFFTLFIGAICHVESLSKSKVLGSFISFVGIIMVTKSDSHQRYQRHIADVSGDDNDAVQVLIGNLLALAGAVLYGVYSTLLKREVGDETRVNMKIFFGFVGLFNLLFLWPSLIVLDFFGWEPFSLPKDPKVVVIIFVNCLITFVSDFCWAKAMLLTSPLTVTVGLSITIPLAMFGDVIFKHKTMSALYLFGATLILGSFFIINKSSEEEHFENSITASNYESVEVPAANN
SIO_010081: YML018C
subclass of: SO_0000673
so part of: YML018C
location: complement(234771..235952)
location: region:234771-235952:-1
so has part: feature:234771-235952:-1:exon

NP_013694.1
type: Protein
SIO_000068: ncbiprotein

S000004480
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234771-235952:-1:exon

YML017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MRS15
gene: PSP2
locus tag: YML017W
gene synonym: MRS15
so part of: sequence
location: <236588..>238731
location: region:236588-238731:1
so has part: feature:236588-238731:1:exon
subclass of: SO_0000010

854991
type: Gene
SIO_000068: ncbigene

position:236588:1
position: 236588
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238731:1
position: 238731
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:236588-238731:1:exon

YML017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MRS15
gene: PSP2
locus tag: YML017W
gene synonym: MRS15
product: Psp2p
transcript id: NM_001182375.1
SIO_010081: YML017W
subclass of: SO_0000673
so part of: YML017W
location: join(<236588..236591,236954..>238731)
location: region:236588-238731:1
so has part: feature:236588-236591:1:exon
so has part: feature:236954-238731:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:236588-236591:1:exon

position:236591:1
position: 236591
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:236954-238731:1:exon

position:236954:1
position: 236954
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YML017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MRS15
gene: PSP2
locus tag: YML017W
gene synonym: MRS15
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
codon start: 1
product: Psp2p
translation: MGTNNTSNNNGTTKKMSLEEFLGNDTLGESVWDEEDINLDAISNTTNIDILKQTKAGEHQRDGHQQHPHGGHGPMNRSRFSNAGPFGGGSMGDFANHHHPLQHQQGPPYIVKFSDLPPRFSNFDIEDLFQAKFTKFIKFKLFWEINKNPSISTLKSGSIFDQNFKRDSKVAFVELYTSRDMDKILNYWTTPLKEIYHITTAPAEFEDFKDYSTKVKLLTDPKDDAGKPFITKTQRSKSNPFGSAKPVDTQSKILDIEEKMENLHVEDTTTLRASLIPSSDSMATTATGSKITILKKQTPTEEESHSATPTPKPLSYSEVVERSVVNETSKKGTPLSKLDSPALELQSKPDKSDEFKGGDEQGFEKGGDDKAQLDVSNDKDKGSETDVDKQFTFKNVEREHSMSRTKYNGNHNNNNGNFRGSNRYRGGPNGSSYKGGHNNRGNRGGYRGGSSYNNNNNNTNDNNNNNNNSSSNNNNGSRYHDRQNNEEGLTSDSSLDASGNKKNDFTNSTSNTQQYSIFKPASGFLGQGNNDSIRNNGRGNYNSSGMNGGSRGRGFGRGRGFGRGAYNNRGSRGGRGSSGNYSNYNNRTTDMPL
SIO_010081: YML017W
subclass of: SO_0000673
so part of: YML017W
location: join(236588..236591,236954..238731)
location: region:236588-238731:1
so has part: feature:236588-236591:1:exon
so has part: feature:236954-238731:1:exon

NP_013695.2
type: Protein
SIO_000068: ncbiprotein

S000004479
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:236588-236591:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:236954-238731:1:exon

YML016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPZ1
locus tag: YML016C
so part of: sequence
location: complement(<239458..>241536)
location: region:239458-241536:-1
so has part: feature:239458-241536:-1:exon
subclass of: SO_0000010

854992
type: Gene
SIO_000068: ncbigene

position:239458:-1
position: 239458
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241536:-1
position: 241536
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:239458-241536:-1:exon

YML016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPZ1
locus tag: YML016C
product: salt homeostasis regulator
transcript id: NM_001182374.1
SIO_010081: YML016C
subclass of: SO_0000673
so part of: YML016C
location: complement(<239458..>241536)
location: region:239458-241536:-1
so has part: feature:239458-241536:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239458-241536:-1:exon

YML016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPZ1
locus tag: YML016C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:7615085]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8824289|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0006883 cellular sodium ion homeostasis [PMID:7768897]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:21237705]
note: Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
codon start: 1
product: salt homeostasis regulator
translation: MGNSSSKSSKKDSHSNSSSRNPRPQVSRTETSHSVKSAKSNKSSRSRRSLPSSSTTNTNSNVPDPSTPSKPNLEVNHQRHSSHTNRYHFPSSSHSHSNSQNELLTTPSSSSTKRPSTSRRSSYNTKAAADLPPSMIQMEPKSPILKTNNSSTHVSKHKSSYSSTYYENALTDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNNGSYSSNNQENYLVQALTRSNSHASSLHSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSGEYFTSNSTSSLNHHSSRDIYPSKHISNDDDIENSSQLSNIHASMENVNDKNNNITDSKKDPNEEFNDIMQSSGNKNAPKKFKKPIDIDETIQKLLDAGYAAKRTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALKQVMKKGRQERKLANQQQQMMETSITNDNESQQ
SIO_010081: YML016C
subclass of: SO_0000673
so part of: YML016C
location: complement(239458..241536)
location: region:239458-241536:-1
so has part: feature:239458-241536:-1:exon

NP_013696.1
type: Protein
SIO_000068: ncbiprotein

S000004478
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239458-241536:-1:exon

YML015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAF40
gene: TAF11
locus tag: YML015C
gene synonym: TAF40
so part of: sequence
location: complement(<241989..>243029)
location: region:241989-243029:-1
so has part: feature:241989-243029:-1:exon
subclass of: SO_0000010

854993
type: Gene
SIO_000068: ncbigene

position:241989:-1
position: 241989
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:243029:-1
position: 243029
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241989-243029:-1:exon

YML015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAF40
gene: TAF11
locus tag: YML015C
gene synonym: TAF40
product: TATA-binding protein-associated factor TAF11
transcript id: NM_001182373.1
SIO_010081: YML015C
subclass of: SO_0000673
so part of: YML015C
location: complement(<241989..>243029)
location: region:241989-243029:-1
so has part: feature:241989-243029:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241989-243029:-1:exon

YML015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAF40
gene: TAF11
locus tag: YML015C
gene synonym: TAF40
experiment: EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity []
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10818000]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9083082]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]
note: TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
codon start: 1
product: TATA-binding protein-associated factor TAF11
translation: MTEPQGPLDTIPKVNYPPILTIANYFSTKQMIDQVISEDQDYVTWKLQNLRTGGTSINNQLNKYPKYKYQKTRINQQDPDSINKVPENLIFPQDILQQQTQNSNYEDTNTNEDENEKLAQDEQFKLLVTNLDKDQTNRFEVFHRTSLNKTQVKKLASTVANQTISENIRVFLQAVGKIYAGEIIELAMIVKNKWLTSQMCIEFDKRTKIGYKLKKYLKKLTFSIIENQQYKQDYQSDSVPEDEPDFYFDDEEVDKRETTLGNSLLQSKSLQQSDHNSQDLKLQLIEQYNKLVLQFNKLDVSIEKYNNSPLLPEHIREAWRLYRLQSDTLPNAYWRTQGEGQGSMFR
SIO_010081: YML015C
subclass of: SO_0000673
so part of: YML015C
location: complement(241989..243029)
location: region:241989-243029:-1
so has part: feature:241989-243029:-1:exon

NP_013697.1
type: Protein
SIO_000068: ncbiprotein

S000004477
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241989-243029:-1:exon

YML014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KTI1
gene: TRM9
locus tag: YML014W
gene synonym: KTI1
so part of: sequence
location: <243225..>244064
location: region:243225-244064:1
so has part: feature:243225-244064:1:exon
subclass of: SO_0000010

854994
type: Gene
SIO_000068: ncbigene

position:243225:1
position: 243225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:244064:1
position: 244064
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243225-244064:1:exon

YML014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KTI1
gene: TRM9
locus tag: YML014W
gene synonym: KTI1
product: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase
transcript id: NM_001182372.1
SIO_010081: YML014W
subclass of: SO_0000673
so part of: YML014W
location: <243225..>244064
location: region:243225-244064:1
so has part: feature:243225-244064:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243225-244064:1:exon

YML014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KTI1
gene: TRM9
locus tag: YML014W
gene synonym: KTI1
EC number: 2.1.1.229
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14645538]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14645538|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016300 tRNA (uracil) methyltransferase activity [PMID:14645538]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:14645538]
experiment: EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]
experiment: EXISTENCE:mutant phenotype:GO:0006448 regulation of translational elongation [PMID:27245397]
experiment: EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:14645538]
note: tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
codon start: 1
product: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase
translation: MEINQAAEKEQEYVHKVYNEIAPHFSQTRYKPWPIVTQFLKTRPMGSIGIDVGCGNGKYLGVNPDIYIIGSDRSDGLIECARGINPSYNLLVADGLNLPHKNETFDFAISIAVVHHWSTRERRVEVIRHVLSKLRQGGQALIYCWALEQGSSRRGYHEGMEQDVFVPWVLPKSKSKPKTKSTPPAKVKTRPKPNLMNIPPKERSEYLQRWKEEQQRSKSLDDNDEKQQQDQEQEREEVKYRYYHLYREGELAEDCRQAGAAVHSEGFERDNWWVVAQKR
SIO_010081: YML014W
subclass of: SO_0000673
so part of: YML014W
location: 243225..244064
location: region:243225-244064:1
so has part: feature:243225-244064:1:exon

NP_013698.1
type: Protein
SIO_000068: ncbiprotein

S000004476
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243225-244064:1:exon

YML013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEL1
gene: UBX2
locus tag: YML013W
gene synonym: SEL1
so part of: sequence
location: <244149..>245903
location: region:244149-245903:1
so has part: feature:244149-245903:1:exon
subclass of: SO_0000010

854995
type: Gene
SIO_000068: ncbigene

position:244149:1
position: 244149
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245903:1
position: 245903
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:244149-245903:1:exon

YML013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEL1
gene: UBX2
locus tag: YML013W
gene synonym: SEL1
product: Ubx2p
transcript id: NM_001182371.1
SIO_010081: YML013W
subclass of: SO_0000673
so part of: YML013W
location: <244149..>245903
location: region:244149-245903:1
so has part: feature:244149-245903:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:244149-245903:1:exon

YML013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEL1
gene: UBX2
locus tag: YML013W
gene synonym: SEL1
experiment: EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16179952]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22454508|PMID:24868093]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16179953]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:31118508]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:31118508]
experiment: EXISTENCE:genetic interaction:GO:0034389 lipid droplet organization [PMID:22454508]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16179952]
experiment: EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:22454508]
experiment: EXISTENCE:mutant phenotype:GO:0034982 mitochondrial protein processing [PMID:31118508]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15258615]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]
experiment: EXISTENCE:physical interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:16179952|PMID:16919153]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:16179952]
note: Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis; required for mitochondrial protein translocation-associated degradation
codon start: 1
product: Ubx2p
translation: MPVVNHEDSEFHLSHTEEDKLNEFQVITNFPPEDLPDVVRLLRNHGWQLEPALSRYFDGEWKGEPDQMGEPTQTSTPMAETLVPPALGPRPLLFTASLPVVRPLPANFRNDFRTIGLNGRSNTVWSMFESFSYDGNPFLFILLLIPRIINRLSATIFTFFCTLLSLHSISGGGNSGKPKISKVPKAPTRETHIPLAEILGDTKDKDAFCELKSFKPDISFNEALRIAKEEFKFMLLILVGDTYDTDTDTVDVNSKLLLEKILLNKKTLQYLRKIDNDLIIYLKCVHELEPWLVARQLGVRNTPEIFLIANVANKASHSETLPSQRLSILGKLKVNSLNRFLQSLTNVVEKYTPELVVNKTEMHELRMSREIKKLQEDAYKKSLEMDRIKAIEKEKSLKHAQDLKLNSTARQLKWLKACIDEIQPFETTGKQATLQFRTSSGKRFVKKFPSMTTLYQIYQSIGCHIYLAVYSSDPAEWSNALQDKIRQLSADDDMLCFKEGQLETATATTIEELGHIINNELTSFDLERGKLEFDFELVSPFPKYTVHPNEHMSVDQVPQLWPNGSLLVEALDEEDEEDEENEEQ
SIO_010081: YML013W
subclass of: SO_0000673
so part of: YML013W
location: 244149..245903
location: region:244149-245903:1
so has part: feature:244149-245903:1:exon

NP_013699.1
type: Protein
SIO_000068: ncbiprotein

S000004475
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:244149-245903:1:exon

YML012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERV25
locus tag: YML012W
so part of: sequence
location: <246116..>246751
location: region:246116-246751:1
so has part: feature:246116-246751:1:exon
subclass of: SO_0000010

854997
type: Gene
SIO_000068: ncbigene

position:246116:1
position: 246116
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246751:1
position: 246751
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246116-246751:1:exon

YML012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERV25
locus tag: YML012W
product: Erv25p
transcript id: NM_001182369.1
SIO_010081: YML012W
subclass of: SO_0000673
so part of: YML012W
location: <246116..>246751
location: region:246116-246751:1
so has part: feature:246116-246751:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246116-246751:1:exon

YML012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERV25
locus tag: YML012W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:18283113]
note: Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24
codon start: 1
product: Erv25p
translation: MQVLQLWLTTLISLVVAVQGLHFDIAASTDPEQVCIRDFVTEGQLVVADIHSDGSVGDGQKLNLFVRDSVGNEYRRKRDFAGDVRVAFTAPSSTAFDVCFENQAQYRGRSLSRAIELDIESGAEARDWNKISANEKLKPIEVELRRVEEITDEIVDELTYLKNREERLRDTNESTNRRVRNFSILVIIVLSSLGVWQVNYLKNYFKTKHII
SIO_010081: YML012W
subclass of: SO_0000673
so part of: YML012W
location: 246116..246751
location: region:246116-246751:1
so has part: feature:246116-246751:1:exon

NP_013701.1
type: Protein
SIO_000068: ncbiprotein

S000004473
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246116-246751:1:exon

YML011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD33
locus tag: YML011C
so part of: sequence
location: complement(<246895..>247428)
location: region:246895-247428:-1
so has part: feature:246895-247428:-1:exon
subclass of: SO_0000010

854998
type: Gene
SIO_000068: ncbigene

position:246895:-1
position: 246895
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:247428:-1
position: 247428
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246895-247428:-1:exon

YML011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD33
locus tag: YML011C
product: Rad33p
transcript id: NM_001182368.1
SIO_010081: YML011C
subclass of: SO_0000673
so part of: YML011C
location: complement(<246895..>247428)
location: region:246895-247428:-1
so has part: feature:246895-247428:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246895-247428:-1:exon

YML011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD33
locus tag: YML011C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:16595192]
note: Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
codon start: 1
product: Rad33p
translation: MSKSTNVSYERVELFENPKVPIEVEDEILEKYAESSLDHDMTVNELPRFFKDLQLEPTIWKLVRNEDVIIEGTDVIDFTKLVRCTCQLLILMNNLTVIDDLWSMLIRNCGRDVDFPQVALRDHVLSVKDLQKISNLIGADQSSGTIEMISCATDGKRLFMTYLDFGCVLGKLGYLKM
SIO_010081: YML011C
subclass of: SO_0000673
so part of: YML011C
location: complement(246895..247428)
location: region:246895-247428:-1
so has part: feature:246895-247428:-1:exon

NP_013702.1
type: Protein
SIO_000068: ncbiprotein

S000004472
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246895-247428:-1:exon

YML010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPT5
locus tag: YML010W
so part of: sequence
location: <247677..>250868
location: region:247677-250868:1
so has part: feature:247677-250868:1:exon
subclass of: SO_0000010

854999
type: Gene
SIO_000068: ncbigene

position:247677:1
position: 247677
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:250868:1
position: 250868
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:247677-250868:1:exon

YML010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPT5
locus tag: YML010W
product: transcription elongation factor SPT5
transcript id: NM_001182366.1
SIO_010081: YML010W
subclass of: SO_0000673
so part of: YML010W
location: <247677..>250868
location: region:247677-250868:1
so has part: feature:247677-250868:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:247677-250868:1:exon

YML010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPT5
locus tag: YML010W
experiment: EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:35102600]
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0001042 RNA polymerase I core binding [PMID:21467036]
experiment: EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:21467036]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:27376968]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1840633]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:35102600]
experiment: EXISTENCE:direct assay:GO:0010508 positive regulation of autophagy [PMID:31462158]
experiment: EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21467036]
experiment: EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:31289129]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:16908835]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:35102600]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0070990 snRNP binding [PMID:31289129]
experiment: EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:20042611]
experiment: EXISTENCE:genetic interaction:GO:2001208 negative regulation of transcription elongation by RNA polymerase I [PMID:21467039]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:20713510]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19365074|PMID:26945063]
experiment: EXISTENCE:mutant phenotype:GO:0044877 protein-containing complex binding [PMID:26945063]
experiment: EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:21949810]
experiment: EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:21467039]
experiment: EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:9450930]
experiment: EXISTENCE:physical interaction:GO:0032044 DSIF complex [PMID:9450930]
note: Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life
codon start: 1
product: transcription elongation factor SPT5
translation: MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQERNRFLDIEAEVSDDEDEDEDEEDSELVREGFITHGDDEDDEASAPGARRDDRLHRQLDQDLNKTSEEDAQRLAKELRERYGRSSSKQYRAAAQDGYVPQRFLLPSVDTATIWGVRCRPGKEKELIRKLLKKKFNLDRAMGKKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFCNGVPDIYISQKLLIPVQELPLLLKPNKSDDVALEEGSYVRIKRGIYKGDLAMVDQISENNLEVMLKIVPRLDYGKFDEIDPTTQQRKSRRPTFAHRAPPQLFNPTMALRLDQANLYKRDDRHFTYKNEDYIDGYLYKSFRIQHVETKNIQPTVEELARFGSKEGAVDLTSVSQSIKKAQAAKVTFQPGDRIEVLNGEQRGSKGIVTRTTKDIATIKLNGFTTPLEFPISTLRKIFEPGDHVTVINGEHQGDAGLVLMVEQGQVTFMSTQTSREVTITANNLSKSIDTTATSSEYALHDIVELSAKNVACIIQAGHDIFKVIDETGKVSTITKGSILSKINTARARVSSVDANGNEIKIGDTIVEKVGSRREGQVLYIQTQQIFVVSKKIVENAGVFVVNPSNVEAVASKDNMLSNKMDLSKMNPEIISKMGPPSSKTFQQPIQSRGGREVALGKTVRIRSAGYKGQLGIVKDVNGDKATVELHSKNKHITIDKHKLTYYNREGGEGITYDELVNRRGRVPQARMGPSYVSAPRNMATGGIAAGAAATSSGLSGGMTPGWSSFDGGKTPAVNAHGGSGGGGVSSWGGASTWGGQGNGGASAWGGAGGGASAWGGQGTGATSTWGGASAWGNKSSWGGASTWASGGESNGAMSTWGGTGDRSAYGGASTWGGNNNNKSTRDGGASAWGNQDDGNRSAWNNQGNKSNYGGNSTWGGH
SIO_010081: YML010W
subclass of: SO_0000673
so part of: YML010W
location: 247677..250868
location: region:247677-250868:1
so has part: feature:247677-250868:1:exon

NP_013703.1
type: Protein
SIO_000068: ncbiprotein

S000004470
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:247677-250868:1:exon

YML009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bL33m
gene: MRPL39
locus tag: YML009C
gene synonym: bL33m
so part of: sequence
location: complement(<251304..>251516)
location: region:251304-251516:-1
so has part: feature:251304-251516:-1:exon
subclass of: SO_0000010

855002
type: Gene
SIO_000068: ncbigene

position:251304:-1
position: 251304
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:251516:-1
position: 251516
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251304-251516:-1:exon

YML009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bL33m
gene: MRPL39
locus tag: YML009C
gene synonym: bL33m
product: mitochondrial 54S ribosomal protein YmL39
transcript id: NM_001182364.1
SIO_010081: YML009C
subclass of: SO_0000673
so part of: YML009C
location: complement(<251304..>251516)
location: region:251304-251516:-1
so has part: feature:251304-251516:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251304-251516:-1:exon

YML009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bL33m
gene: MRPL39
locus tag: YML009C
gene synonym: bL33m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL39
translation: MVKVKSKNSVIKLLSTAASGYSRYISIKKGAPLVTQVRYDPVVKRHVLFKEAKKRKVAERKPLDFLRTAK
SIO_010081: YML009C
subclass of: SO_0000673
so part of: YML009C
location: complement(251304..251516)
location: region:251304-251516:-1
so has part: feature:251304-251516:-1:exon

NP_013705.1
type: Protein
SIO_000068: ncbiprotein

S000004468
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251304-251516:-1:exon

YML008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISE1
alternative label: LIS1
alternative label: SED6
alternative label: VID1
gene: ERG6
locus tag: YML008C
gene synonym: ISE1; LIS1; SED6; VID1
so part of: sequence
location: complement(<251839..>252990)
location: region:251839-252990:-1
so has part: feature:251839-252990:-1:exon
subclass of: SO_0000010

855003
type: Gene
SIO_000068: ncbigene

position:251839:-1
position: 251839
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:252990:-1
position: 252990
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251839-252990:-1:exon

YML008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISE1
alternative label: LIS1
alternative label: SED6
alternative label: VID1
gene: ERG6
locus tag: YML008C
gene synonym: ISE1; LIS1; SED6; VID1
product: sterol 24-C-methyltransferase
transcript id: NM_001182363.1
SIO_010081: YML008C
subclass of: SO_0000673
so part of: YML008C
location: complement(<251839..>252990)
location: region:251839-252990:-1
so has part: feature:251839-252990:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251839-252990:-1:exon

YML008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISE1
alternative label: LIS1
alternative label: SED6
alternative label: VID1
gene: ERG6
locus tag: YML008C
gene synonym: ISE1; LIS1; SED6; VID1
EC number: 2.1.1.41
experiment: EXISTENCE:direct assay:GO:0003838 sterol 24-C-methyltransferase activity [PMID:18563465|PMID:6363386]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11298754|PMID:9450962|PMID:6363386]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:6363386]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:2677674|PMID:6363386]
note: Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane
codon start: 1
product: sterol 24-C-methyltransferase
translation: MSETELRKRQAQFTRELHGDDIGKKTGLSALMSKNNSAQKEAVQKYLRNWDGRTDKDAEERRLEDYNEATHSYYNVVTDFYEYGWGSSFHFSRFYKGESFAASIARHEHYLAYKAGIQRGDLVLDVGCGVGGPAREIARFTGCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVYSEIYKVLKPGGTFAVYEWVMTDKYDENNPEHRKIAYEIELGDGIPKMFHVDVARKALKNCGFEVLVSEDLADNDDEIPWYYPLTGEWKYVQNLANLATFFRTSYLGRQFTTAMVTVMEKLGLAPEGSKEVTAALENAAVGLVAGGKSKLFTPMMLFVARKPENAETPSQTSQEATQ
SIO_010081: YML008C
subclass of: SO_0000673
so part of: YML008C
location: complement(251839..252990)
location: region:251839-252990:-1
so has part: feature:251839-252990:-1:exon

NP_013706.1
type: Protein
SIO_000068: ncbiprotein

S000004467
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251839-252990:-1:exon

YML007C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIN4
locus tag: YML007C-A
so part of: sequence
location: complement(<253162..>253272)
location: region:253162-253272:-1
so has part: feature:253162-253272:-1:exon
subclass of: SO_0000010

855004
type: Gene
SIO_000068: ncbigene

position:253162:-1
position: 253162
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253272:-1
position: 253272
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253162-253272:-1:exon

YML007C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIN4
locus tag: YML007C-A
product: Min4p
transcript id: NM_001184487.1
SIO_010081: YML007C-A
subclass of: SO_0000673
so part of: YML007C-A
location: complement(<253162..>253272)
location: region:253162-253272:-1
so has part: feature:253162-253272:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253162-253272:-1:exon

YML007C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIN4
locus tag: YML007C-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: Mitochondrial hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
codon start: 1
product: Min4p
translation: MVHFIFIALRSMRFMRRLVRNLQYLLLPITSSLLFI
SIO_010081: YML007C-A
subclass of: SO_0000673
so part of: YML007C-A
location: complement(253162..253272)
location: region:253162-253272:-1
so has part: feature:253162-253272:-1:exon

NP_076904.1
type: Protein
SIO_000068: ncbiprotein

S000007621
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253162-253272:-1:exon

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: Upstream open reading frame (uORF) in 5' untranslated region of YAP1 gene, regulate translation
so part of: sequence
location: 253763..253783
location: region:253763-253783:1
so has part: feature:253763-253783:1:region

position:253763:1
position: 253763
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:253783:1
position: 253783
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253763-253783:1:region

YML007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAR1
alternative label: PDR4
alternative label: SNQ3
gene: YAP1
locus tag: YML007W
gene synonym: PAR1; PDR4; SNQ3
so part of: sequence
location: <253848..>255800
location: region:253848-255800:1
so has part: feature:253848-255800:1:exon
subclass of: SO_0000010

855005
type: Gene
SIO_000068: ncbigene

position:253848:1
position: 253848
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255800:1
position: 255800
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253848-255800:1:exon

YML007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAR1
alternative label: PDR4
alternative label: SNQ3
gene: YAP1
locus tag: YML007W
gene synonym: PAR1; PDR4; SNQ3
product: DNA-binding transcription factor YAP1
transcript id: NM_001182362.1
SIO_010081: YML007W
subclass of: SO_0000673
so part of: YML007W
location: <253848..>255800
location: region:253848-255800:1
so has part: feature:253848-255800:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253848-255800:1:exon

YML007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAR1
alternative label: PDR4
alternative label: SNQ3
gene: YAP1
locus tag: YML007W
gene synonym: PAR1; PDR4; SNQ3
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:11056165]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9130715|PMID:12582119|PMID:24034606|PMID:27838435|PM ID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9130715|PMID:12582119|PMID:24034606|PMID:11914276|PM ID:22842922]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11056165]
experiment: EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:16862604]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10809786]
experiment: EXISTENCE:mutant phenotype:GO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [PMID:15575969]
experiment: EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:27373166]
note: Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication
codon start: 1
product: DNA-binding transcription factor YAP1
translation: MSVSTAKRSLDVVSPGSLAEFEGSKSRHDEIENEHRRTGTRDGEDSEQPKKKGSKTSKKQDLDPETKQKRTAQNRAAQRAFRERKERKMKELEKKVQSLESIQQQNEVEATFLRDQLITLVNELKKYRPETRNDSKVLEYLARRDPNLHFSKNNVNHSNSEPIDTPNDDIQENVKQKMNFTFQYPLDNDNDNDNSKNVGKQLPSPNDPSHSAPMPINQTQKKLSDATDSSSATLDSLSNSNDVLNNTPNSSTSMDWLDNVIYTNRFVSGDDGSNSKTKNLDSNMFSNDFNFENQFDEQVSEFCSKMNQVCGTRQCPIPKKPISALDKEVFASSSILSSNSPALTNTWESHSNITDNTPANVIATDATKYENSFSGFGRLGFDMSANHYVVNDNSTGSTDSTGSTGNKNKKNNNNSDDVLPFISESPFDMNQVTNFFSPGSTGIGNNAASNTNPSLLQSSKEDIPFINANLAFPDDNSTNIQLQPFSESQSQNKFDYDMFFRDSSKEGNNLFGEFLEDDDDDKKAANMSDDESSLIKNQLINEEPELPKQYLQSVPGNESEISQKNGSSLQNADKINNGNDNDNDNDVVPSKEGSLLRCSEIWDRITTHPKYSDIDVDGLCSELMAKAKCSERGVVINAEDVQLALNKHMN
SIO_010081: YML007W
subclass of: SO_0000673
so part of: YML007W
location: 253848..255800
location: region:253848-255800:1
so has part: feature:253848-255800:1:exon

NP_013707.1
type: Protein
SIO_000068: ncbiprotein

S000004466
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253848-255800:1:exon

YML006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIS4
locus tag: YML006C
so part of: sequence
location: complement(<256092..>258416)
location: region:256092-258416:-1
so has part: feature:256092-258416:-1:exon
subclass of: SO_0000010

855006
type: Gene
SIO_000068: ncbigene

position:256092:-1
position: 256092
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:258416:-1
position: 258416
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256092-258416:-1:exon

YML006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIS4
locus tag: YML006C
product: Gis4p
transcript id: NM_001182361.1
SIO_010081: YML006C
subclass of: SO_0000673
so part of: YML006C
location: complement(<256092..>258416)
location: region:256092-258416:-1
so has part: feature:256092-258416:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256092-258416:-1:exon

YML006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIS4
locus tag: YML006C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17030993]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0035556 intracellular signal transduction [PMID:10628841]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:17030993]
note: CAAX box containing hypothetical protein; proposed to be involved in the RAS/cAMP signaling pathway
codon start: 1
product: Gis4p
translation: MQKSVRVGDYFDNDDNGLWSWYLTNLRLGDFEELIGNQLKYTLLKRFLNSHFYGDNNISARPNKKILLVSIPENVHEDISILEIFLKDYFHLEKLEHIQISKLTHSHCYNHENHYLLTDNLNNFQDPTFLEFASTSWQVQKNSKALNNNNRNSIPPPTISSSKASNGKLESNVSDDQWSNINTQTSTATRTNTNTRTLTSPDTVDINVTSVNSQSNNNDTPQDNENEVDEEDATSSIVLNFSHSRTVDSKPNRLPKIFPSYTNEDYTPSHSEIMSIDSFAGEDVSSTYPGQDLSLTTARREDESGQDEVEDHYSRVSHDLGDESIDQASYSMESSVSYTSYSSSSNSSSAHYSLSSSSRGNPKRENIDHTNATYVSELSSITSSIDNLTTSTTPEEEDNLIHHNYDAQGYGSGEDDGEEVYDDEDLSSSDYSVLSILPSISICDSLGYFRLVLQSILIQDPDTKEIFTAIRQSNNKPTMASVTDDWLLYDSNFSMNNLQILTLQDLLDIKRSFPKILFYTMVIVTNSGKQVEEEFKNPNYDNREGISKEQPLDSELSLTNDPQQYFPTAYNNGYNDYIDDEDDEDDGDDASLSEQSGPQMYIPTRMESNVTTAHRSIRTVNSIGEWAFNRHNSVTKIDKSNSNELDNSKTGESTVLSSEPHPMTQLSNSNTTSSNFSHSLKTKNSHKPNSKGNNESNSKNELKKIKSSINAMSAVERSKSLPLPTLLKSLSGIDNPTHATNKDRKRWKFQMNRFKNHKNSGSAGTDKSQRCAIM
SIO_010081: YML006C
subclass of: SO_0000673
so part of: YML006C
location: complement(256092..258416)
location: region:256092-258416:-1
so has part: feature:256092-258416:-1:exon

NP_013708.1
type: Protein
SIO_000068: ncbiprotein

S000004465
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256092-258416:-1:exon

YNCM0009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0009C
so part of: sequence
location: complement(259158..259239)
location: region:259158-259239:-1
so has part: feature:259158-259239:-1:exon
subclass of: SO_0000663

855007
type: Gene
SIO_000068: ncbigene

position:259158:-1
position: 259158
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:259239:-1
position: 259239
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259158-259239:-1:exon

YNCM0009C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0009C
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0009C
subclass of: SO_0000673
so part of: YNCM0009C
location: complement(259158..259239)
location: region:259158-259239:-1
so has part: feature:259158-259239:-1:exon

S000006729
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259158-259239:-1:exon

YML005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TYW2
gene: TRM12
locus tag: YML005W
gene synonym: TYW2
so part of: sequence
location: <260221..>261609
location: region:260221-261609:1
so has part: feature:260221-261609:1:exon
subclass of: SO_0000010

855008
type: Gene
SIO_000068: ncbigene

position:260221:1
position: 260221
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:261609:1
position: 261609
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:260221-261609:1:exon

YML005W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TYW2
gene: TRM12
locus tag: YML005W
gene synonym: TYW2
product: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
transcript id: NM_001182360.1
SIO_010081: YML005W
subclass of: SO_0000673
so part of: YML005W
location: <260221..>261609
location: region:260221-261609:1
so has part: feature:260221-261609:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:260221-261609:1:exon

YML005W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TYW2
gene: TRM12
locus tag: YML005W
gene synonym: TYW2
EC number: 2.5.1.114
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16005430]
experiment: EXISTENCE:direct assay:GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups [PMID:16642040]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16005430]
experiment: EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:16642040|PMID:17150819]
note: S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family
codon start: 1
product: tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
translation: MSDETMPVEFLVSDKRLLKTIKVKLETNGLFVTPIYSDNDNKVIKSSIEDLNHPLAVEINNIAGVKARFHESGNLERSEGHLKHQSNSITEFTKSFLKDHGLANDKIFLSHLLDHLPLKYTIYPPVVLFNNSTVRSFNHPIWQKAFQLKLFDPNEYYRELLCFLSPGKPSKGTSLHPNNRLLTHLAINNPITEADVLRRPFNIQPLYGKLIDDSILDDNDNTLWENPSQEQLNSSIWCKVIQNGVTQIWSPVFTMFSRGNIKEKKRVLTTFPDICNNDVVDLYAGIGYFTFSYLTKGARTLFAFELNPWSVEGLKRGLKANGFNKSGNCHVFQESNEMCVQRLTEFLSQNPGFRLRIRHINLGLLPSSKQGWPLAIKLIYLQGASLEKVTMHIHENVHIDAIEDGSFEKNVIVELDAINESIALIRNRGIKLQFVRSKLERIKTFAPDIWHVCVDVDVIVST
SIO_010081: YML005W
subclass of: SO_0000673
so part of: YML005W
location: 260221..261609
location: region:260221-261609:1
so has part: feature:260221-261609:1:exon

NP_013709.1
type: Protein
SIO_000068: ncbiprotein

S000004464
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:260221-261609:1:exon

YML004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLO1
locus tag: YML004C
so part of: sequence
location: complement(<261705..>262685)
location: region:261705-262685:-1
so has part: feature:261705-262685:-1:exon
subclass of: SO_0000010

855009
type: Gene
SIO_000068: ncbigene

position:261705:-1
position: 261705
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:262685:-1
position: 262685
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:261705-262685:-1:exon

YML004C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLO1
locus tag: YML004C
product: lactoylglutathione lyase GLO1
transcript id: NM_001182359.1
SIO_010081: YML004C
subclass of: SO_0000673
so part of: YML004C
location: complement(<261705..>262685)
location: region:261705-262685:-1
so has part: feature:261705-262685:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:261705-262685:-1:exon

YML004C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLO1
locus tag: YML004C
EC number: 4.4.1.5
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:8824231]
experiment: EXISTENCE:mutant phenotype:GO:0004462 lactoylglutathione lyase activity [PMID:8824231]
experiment: EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:8824231]
note: Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress
codon start: 1
product: lactoylglutathione lyase GLO1
translation: MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHFGMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDYKINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGYWIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAKFTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDDAGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA
SIO_010081: YML004C
subclass of: SO_0000673
so part of: YML004C
location: complement(261705..262685)
location: region:261705-262685:-1
so has part: feature:261705-262685:-1:exon

NP_013710.1
type: Protein
SIO_000068: ncbiprotein

S000004463
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:261705-262685:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1309; Autonomously Replicating Sequence
so part of: sequence
location: 263063..263296
location: region:263063-263296:1
so has part: feature:263063-263296:1:region

S000118369
type: SGD
SIO_000068: sgd

position:263063:1
position: 263063
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:263296:1
position: 263296
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263063-263296:1:region

YML003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VRL1
locus tag: YML003W
gene synonym: VRL1
so part of: sequence
location: <263483..>264355
location: region:263483-264355:1
so has part: feature:263483-264355:1:exon
subclass of: SO_0000010

855010
type: Gene
SIO_000068: ncbigene

position:263483:1
position: 263483
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:264355:1
position: 264355
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263483-264355:1:exon

YML003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VRL1
locus tag: YML003W
gene synonym: VRL1
product: uncharacterized protein
transcript id: NM_001182358.1
SIO_010081: YML003W
subclass of: SO_0000673
so part of: YML003W
location: <263483..>264355
location: region:263483-264355:1
so has part: feature:263483-264355:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263483-264355:1:exon

YML003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VRL1
locus tag: YML003W
gene synonym: VRL1
note: Truncated 5' end of YML002W; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W
codon start: 1
product: uncharacterized protein
translation: MSVYHLPTLLNPLVNAIFNCPEPERSPLKKLFANLKTRRFILLAPPSEYLLNYHDVKSKLPLHDLCYNAEFINSYILLMTENSYINTNSRDSHYETLDGKTVVIQWKNNVIHALNGFHIRRRLKILETKILPNFNDYFEGAADFIILFIDQPLNCEFVPNDYLQCFHNYEKIPKNAHAMPNLSIDSFQQERSSFENILHIHPARLTQLGQLFSSYRTLAPGDDPSRSIFESIVQQAFDGMKSDSLFKNFSNLYDLIHDYFELNLYDDIWSRLTTHFKGHEVDTEKINIFQ
SIO_010081: YML003W
subclass of: SO_0000673
so part of: YML003W
location: 263483..264355
location: region:263483-264355:1
so has part: feature:263483-264355:1:exon

NP_013711.1
type: Protein
SIO_000068: ncbiprotein

S000004462
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263483-264355:1:exon

YML002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VRL1
locus tag: YML002W
so part of: sequence
location: <264541..>266754
location: region:264541-266754:1
so has part: feature:264541-266754:1:exon
subclass of: SO_0000010

855011
type: Gene
SIO_000068: ncbigene

position:264541:1
position: 264541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266754:1
position: 266754
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264541-266754:1:exon

YML002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VRL1
locus tag: YML002W
product: Vrl1p
transcript id: NM_001182357.1
SIO_010081: YML002W
subclass of: SO_0000673
so part of: YML002W
location: <264541..>266754
location: region:264541-266754:1
so has part: feature:264541-266754:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264541-266754:1:exon

YML002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VRL1
locus tag: YML002W
note: hypothetical protein; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W
codon start: 1
product: Vrl1p
translation: MDSHQLELPDGLNNMTMDADTLISLFVLVVCRSEQKHLKSHLYYLQNFSNNSSSTKFGILGYAVSTLEAVVCYFEDFNKNTGNVAKANTLCEKTKNLLDKLSCENPTNEVEDLATYKDILTYRNEQGQSILSICITNHKNYILLDILSEYENDFPVEDLLEDETIDGSTLLIESIKAGNLEAAKVLIKIMLFNCTEEELVSYINKTDKYARTVAHYLTHEMDILKSIGNYIDWKRKNSSGQTPLFSIFRSYDQPNYEEMVKTAFDIANTWYRKHNSLFDYLDHTDNKGNSLLHVLKTNIPILLQLTKLDINEENYKGLTPLMVYVKYKRLSNIDAITKDRRLILEKVQNSTFFTCFDYAKDHSVLSKIGERGVKDSLFGLIYFHSLRYHNLNATTNITSVSNAEKPFATTVINMKTIQGLLRSILKDNPFTFLPLNTYIDEISHLNRSDLTIIGKTDVTSLLHQLTNCFNVLLFLKKIPENLFTDEASILYWMRINTSKRNQKPSGKENPKTMEPEEINMIQSFLRFNFDEISSFKASLNILRKVLIFINLKSDDFEDAYKGLNEMGRKLINSEASSAFKGIITNHNMFSELSLAALLENVRFLEQCTIQLSSFVQIILFEKIPNWWKHYGEFLALHKSYRKAFPNMVKPKSASDTSSRAPLGGFIETKREQSEQRLAVQIKASSKMLKELGSEIFVAHERLAEELSNYMEFRKACLDQRSLVAFATTNISVLQECV
SIO_010081: YML002W
subclass of: SO_0000673
so part of: YML002W
location: 264541..266754
location: region:264541-266754:1
so has part: feature:264541-266754:1:exon

NP_013712.1
type: Protein
SIO_000068: ncbiprotein

S000004461
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264541-266754:1:exon

YML001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AST4
alternative label: VAM4
gene: YPT7
locus tag: YML001W
gene synonym: AST4; VAM4
so part of: sequence
location: <267174..>267800
location: region:267174-267800:1
so has part: feature:267174-267800:1:exon
subclass of: SO_0000010

855012
type: Gene
SIO_000068: ncbigene

position:267174:1
position: 267174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:267800:1
position: 267800
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267174-267800:1:exon

YML001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AST4
alternative label: VAM4
gene: YPT7
locus tag: YML001W
gene synonym: AST4; VAM4
product: Rab family GTPase YPT7
transcript id: NM_001182356.1
SIO_010081: YML001W
subclass of: SO_0000673
so part of: YML001W
location: <267174..>267800
location: region:267174-267800:1
so has part: feature:267174-267800:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267174-267800:1:exon

YML001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AST4
alternative label: VAM4
gene: YPT7
locus tag: YML001W
gene synonym: AST4; VAM4
experiment: EXISTENCE:direct assay:GO:0000011 vacuole inheritance [PMID:7489715]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593205|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:9015302]
experiment: EXISTENCE:direct assay:GO:0043254 regulation of protein-containing complex assembly [PMID:32160129]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:22593205]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026035]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:1473149]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008|PMID:7489715]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:22593205]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:11062257|PMID:18809726|PMID:20604902|PMID:21325627]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:22593205]
note: Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
codon start: 1
product: Rab family GTPase YPT7
translation: MSSRKKNILKVIILGDSGVGKTSLMHRYVNDKYSQQYKATIGADFLTKEVTVDGDKVATMQVWDTAGQERFQSLGVAFYRGADCCVLVYDVTNASSFENIKSWRDEFLVHANVNSPETFPFVILGNKIDAEESKKIVSEKSAQELAKSLGDIPLFLTSAKNAINVDTAFEEIARSALQQNQADTEAFEDDYNDAINIRLDGENNSCSC
SIO_010081: YML001W
subclass of: SO_0000673
so part of: YML001W
location: 267174..267800
location: region:267174-267800:1
so has part: feature:267174-267800:1:exon

NP_013713.1
type: Protein
SIO_000068: ncbiprotein

S000004460
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267174-267800:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN13; Chromosome XIII centromere
so part of: sequence
location: 268031..268149
location: region:268031-268149:1
so has part: feature:268031-268149:1:region

S000006474
type: SGD
SIO_000068: sgd

position:268031:1
position: 268031
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:268149:1
position: 268149
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268031-268149:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN13_CDEI of CEN13
so part of: sequence
location: 268031..268040
location: region:268031-268040:1
so has part: feature:268031-268040:1:region

position:268040:1
position: 268040
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268031-268040:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN13_CDEII of CEN13
so part of: sequence
location: 268041..268124
location: region:268041-268124:1
so has part: feature:268041-268124:1:region

position:268041:1
position: 268041
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:268124:1
position: 268124
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268041-268124:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN13_CDEIII of CEN13
so part of: sequence
location: 268125..268149
location: region:268125-268149:1
so has part: feature:268125-268149:1:region

position:268125:1
position: 268125
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268125-268149:1:region

YMR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MSD2
alternative label: PKX2
gene: CDC5
locus tag: YMR001C
gene synonym: MSD2; PKX2
so part of: sequence
location: complement(<269019..>271136)
location: region:269019-271136:-1
so has part: feature:269019-271136:-1:exon
subclass of: SO_0000010

855013
type: Gene
SIO_000068: ncbigene

position:269019:-1
position: 269019
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271136:-1
position: 271136
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:269019-271136:-1:exon

YMR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MSD2
alternative label: PKX2
gene: CDC5
locus tag: YMR001C
gene synonym: MSD2; PKX2
product: polo kinase CDC5
transcript id: NM_001182497.1
SIO_010081: YMR001C
subclass of: SO_0000673
so part of: YMR001C
location: complement(<269019..>271136)
location: region:269019-271136:-1
so has part: feature:269019-271136:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:269019-271136:-1:exon

YMR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MSD2
alternative label: PKX2
gene: CDC5
locus tag: YMR001C
gene synonym: MSD2; PKX2
EC number: 2.7.11.21
experiment: EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:10594031]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:12637549|PMID:17122856|PMID:8321244|PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:21498574]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9819423]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10594031]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:27226485]
experiment: EXISTENCE:direct assay:GO:0044732 mitotic spindle pole body [PMID:32553169]
experiment: EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:27325700]
experiment: EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:21937712]
experiment: EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:18500339]
experiment: EXISTENCE:genetic interaction:GO:0070194 synaptonemal complex disassembly [PMID:18832066]
experiment: EXISTENCE:genetic interaction:GO:1902542 regulation of protein localization to mitotic spindle pole body [PMID:21937712]
experiment: EXISTENCE:genetic interaction:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]
experiment: EXISTENCE:mutant phenotype:GO:0000712 resolution of meiotic recombination intermediates [PMID:12717442]
experiment: EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:17122856|PMID:8321244]
experiment: EXISTENCE:mutant phenotype:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:18500339]
experiment: EXISTENCE:mutant phenotype:GO:0035025 positive regulation of Rho protein signal transduction [PMID:16763112]
experiment: EXISTENCE:mutant phenotype:GO:0090306 meiotic spindle assembly [PMID:20237423|PMID:24386320]
experiment: EXISTENCE:mutant phenotype:GO:0110083 positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:16763112]
experiment: EXISTENCE:mutant phenotype:GO:1903353 regulation of nucleus organization [PMID:25454593]
experiment: EXISTENCE:mutant phenotype:GO:1904749 regulation of protein localization to nucleolus [PMID:33481703]
experiment: EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]
experiment: EXISTENCE:physical interaction:GO:0044877 protein-containing complex binding [PMID:27226485|PMID:27325700]
note: Polo-like kinase required for mitotic exit; regulates mitotic spindle assembly, nuclear shape, and protein localization to the nucleolus and SPBs; controls targeting and activation of Rho1p at the division site via Rho1p-GEFs; role in adaptation to DNA damage promotes genome instability during replicative senescence; regulates meiotic commitment, spindle assembly, chiasmata formation, recombination intermediate resolution and SC disassembly; human homologs PLK1 and PLK3 complement cdc5 mutants
codon start: 1
product: polo kinase CDC5
translation: MSLGPLKAINDKQLNTRSKLVHTPIKGNTADLVGKENHFKQTKRLDPNNDHHHQPAQKKKREKLSALCKTPPSLIKTRGKDYHRGHFLGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDKLEEYHQNRPFLPHSLSPGGTKQKYKEVVDIEAQRRLNDLAREARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLPKSRLPKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLSRVSTFGREEYHKDDVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD
SIO_010081: YMR001C
subclass of: SO_0000673
so part of: YMR001C
location: complement(269019..271136)
location: region:269019-271136:-1
so has part: feature:269019-271136:-1:exon

NP_013714.1
type: Protein
SIO_000068: ncbiprotein

S000004603
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:269019-271136:-1:exon

YMR001C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR001C-A
so part of: sequence
location: complement(<271347..>271577)
location: region:271347-271577:-1
so has part: feature:271347-271577:-1:exon
subclass of: SO_0000010

1466498
type: Gene
SIO_000068: ncbigene

position:271347:-1
position: 271347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271577:-1
position: 271577
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271347-271577:-1:exon

YMR001C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR001C-A
product: uncharacterized protein
transcript id: NM_001184613.1
SIO_010081: YMR001C-A
subclass of: SO_0000673
so part of: YMR001C-A
location: complement(<271347..>271577)
location: region:271347-271577:-1
so has part: feature:271347-271577:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271347-271577:-1:exon

YMR001C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR001C-A
codon start: 1
product: uncharacterized protein
translation: MIFECTSFETRHILNSYSCATQLSYNTYRITEKVNPIQAAVSKNNKPFVSNSDSAFFPIFSSFNFVAYTTLTFKKT
SIO_010081: YMR001C-A
subclass of: SO_0000673
so part of: YMR001C-A
location: complement(271347..271577)
location: region:271347-271577:-1
so has part: feature:271347-271577:-1:exon

NP_878140.1
type: Protein
SIO_000068: ncbiprotein

S000028691
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271347-271577:-1:exon

YMR002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MIC17
gene: MIX17
locus tag: YMR002W
gene synonym: MIC17
so part of: sequence
location: <272193..>272663
location: region:272193-272663:1
so has part: feature:272193-272663:1:exon
subclass of: SO_0000010

855014
type: Gene
SIO_000068: ncbigene

position:272193:1
position: 272193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:272663:1
position: 272663
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272193-272663:1:exon

YMR002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MIC17
gene: MIX17
locus tag: YMR002W
gene synonym: MIC17
product: Mix17p
transcript id: NM_001182498.1
SIO_010081: YMR002W
subclass of: SO_0000673
so part of: YMR002W
location: <272193..>272663
location: region:272193-272663:1
so has part: feature:272193-272663:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272193-272663:1:exon

YMR002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MIC17
gene: MIX17
locus tag: YMR002W
gene synonym: MIC17
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:19703468]
note: Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
codon start: 1
product: Mix17p
translation: MARSRGSSRPISRSRPTQTRSASTMAAPVHPQQQQQPNAYSHPPAAGAQTRQPGMFAQMASTAAGVAVGSTIGHTLGAGITGMFSGSGSDSAPVEQQQQNMANTSGQTQTDQQLGRTCEIDARNFTRCLDENNGNFQICDYYLQQLKACQEAARQY
SIO_010081: YMR002W
subclass of: SO_0000673
so part of: YMR002W
location: 272193..272663
location: region:272193-272663:1
so has part: feature:272193-272663:1:exon

NP_013715.1
type: Protein
SIO_000068: ncbiprotein

S000004604
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272193-272663:1:exon

YMR003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM34
locus tag: YMR003W
so part of: sequence
location: <273118..>273714
location: region:273118-273714:1
so has part: feature:273118-273714:1:exon
subclass of: SO_0000010

855015
type: Gene
SIO_000068: ncbigene

position:273118:1
position: 273118
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273714:1
position: 273714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:273118-273714:1:exon

YMR003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM34
locus tag: YMR003W
product: Aim34p
transcript id: NM_001182499.1
SIO_010081: YMR003W
subclass of: SO_0000673
so part of: YMR003W
location: <273118..>273714
location: region:273118-273714:1
so has part: feature:273118-273714:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:273118-273714:1:exon

YMR003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM34
locus tag: YMR003W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: hypothetical protein; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
codon start: 1
product: Aim34p
translation: MSISLLGRIVSQQFSGIRAAEPGRSLYLPFTLLLKQPGAYKVSLHRYVHSTQTKSHLSFLMNNNDITPFQKFTVKVLKEQCKSRGLKLSGRKSDLLQRLITHDSCSNKKSSVKINEPKKKRILINDPIKITKKLVSDKTFRTIEKNISSLQNTPVIETPCDVHSHLQPRDRIFLLGFFMLSCLWWNLEPQESKPTIDH
SIO_010081: YMR003W
subclass of: SO_0000673
so part of: YMR003W
location: 273118..273714
location: region:273118-273714:1
so has part: feature:273118-273714:1:exon

NP_013716.1
type: Protein
SIO_000068: ncbiprotein

S000004605
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:273118-273714:1:exon

YMR004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MVP1
locus tag: YMR004W
so part of: sequence
location: <274017..>275552
location: region:274017-275552:1
so has part: feature:274017-275552:1:exon
subclass of: SO_0000010

855016
type: Gene
SIO_000068: ncbigene

position:274017:1
position: 274017
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:275552:1
position: 275552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274017-275552:1:exon

YMR004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MVP1
locus tag: YMR004W
product: Mvp1p
transcript id: NM_001182500.1
SIO_010081: YMR004W
subclass of: SO_0000673
so part of: YMR004W
location: <274017..>275552
location: region:274017-275552:1
so has part: feature:274017-275552:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274017-275552:1:exon

YMR004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MVP1
locus tag: YMR004W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21954159]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7862158]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:24567361]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:direct assay:GO:0097320 plasma membrane tubulation [PMID:24567361]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:7862158]
experiment: EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:24567361]
note: Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
codon start: 1
product: Mvp1p
translation: MDNYEGSDPWNTSSNAWTKDDDHVVSTTNSEPSLNGISGEFNTLNFSTPLDTNEEDTGFLPTNDVLEESIWDDSRNPLGATGMSQTPNIAANETVIDKNDARDQNIEESEADLLDWTNNVRKTYRPLDADIIIIEEIPEREGLLFKHANYLVKHLIALPSTSPSEERTVVRRYSDFLWLREILLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLSRFINLVMKHPKLSNDDLVLTFLTVRTDLTSWRKQATYDTSNEFADKKISQEFMKMWKKEFAEQWNQAASCIDTSMELWYRITLLLERHEKRIMQMVHERNFFETLVDNFSEVTPKLYPVQQNDTILDINNNLSIIKKHLETTSSICKQETEEISGTLSPKFKIFTDILLSLRSLFERYKIMAANNVVELQRHVELNKEKLESMKGKPDVSGAEYDRIKKIIQKDRRSIIEQSNRAWLIRQCILEEFTIFQETQFLITRAFQDWAKLNSNHAGLKLNEWEKLVTSIMDMPISRE
SIO_010081: YMR004W
subclass of: SO_0000673
so part of: YMR004W
location: 274017..275552
location: region:274017-275552:1
so has part: feature:274017-275552:1:exon

NP_013717.1
type: Protein
SIO_000068: ncbiprotein

S000004606
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274017-275552:1:exon

YMR005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPT1
alternative label: TAF48
alternative label: TSG2
gene: TAF4
locus tag: YMR005W
gene synonym: MPT1; TAF48; TSG2
so part of: sequence
location: <276045..>277211
location: region:276045-277211:1
so has part: feature:276045-277211:1:exon
subclass of: SO_0000010

855017
type: Gene
SIO_000068: ncbigene

position:276045:1
position: 276045
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:277211:1
position: 277211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276045-277211:1:exon

YMR005W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPT1
alternative label: TAF48
alternative label: TSG2
gene: TAF4
locus tag: YMR005W
gene synonym: MPT1; TAF48; TSG2
product: Taf4p
transcript id: NM_001182501.1
SIO_010081: YMR005W
subclass of: SO_0000673
so part of: YMR005W
location: <276045..>277211
location: region:276045-277211:1
so has part: feature:276045-277211:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:276045-277211:1:exon

YMR005W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPT1
alternative label: TAF48
alternative label: TSG2
gene: TAF4
locus tag: YMR005W
gene synonym: MPT1; TAF48; TSG2
experiment: EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:15448131]
experiment: EXISTENCE:curator inference:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10788514]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12600943]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
note: TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
codon start: 1
product: Taf4p
translation: MANSPKKPSDGTGVSASDTPKYQHTVPETKPAFNLSPGKASELSHSLPSPSQIKSTAHVSSTHNDAAGNTDDSVLPKNVSPTTNLRVESNGDTNNMFSSPAGLALPKKDDKKKNKGTSKADSKDGKASNSSGQNAQQQSDPNKMQDVLFSAGIDVREEEALLNSSINASKSQVQTNNVKIPNHLPFLHPEQVSNYMRKVGKEQNFNLTPTKNPEILDMMSSACENYMRDILTNAIVISRHRRKAVKINSGRRSEVSAALRAIALIQKKEEERRVKKRIALGLEKEDYENKIDSEETLHRASNVTAGLRAGSKKQYGWLTSSVNKPTSLGAKSSGKVASDITARGESGLKFREAREEPGIVMRDLLFALENRRNSVQTIISKGYAKIRD
SIO_010081: YMR005W
subclass of: SO_0000673
so part of: YMR005W
location: 276045..277211
location: region:276045-277211:1
so has part: feature:276045-277211:1:exon

NP_013718.1
type: Protein
SIO_000068: ncbiprotein

S000004607
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:276045-277211:1:exon

YMR006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PLB2
locus tag: YMR006C
so part of: sequence
location: complement(<277561..>279681)
location: region:277561-279681:-1
so has part: feature:277561-279681:-1:exon
subclass of: SO_0000010

855018
type: Gene
SIO_000068: ncbigene

position:277561:-1
position: 277561
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:279681:-1
position: 279681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:277561-279681:-1:exon

YMR006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PLB2
locus tag: YMR006C
product: lysophospholipase
transcript id: NM_001182502.1
SIO_010081: YMR006C
subclass of: SO_0000673
so part of: YMR006C
location: complement(<277561..>279681)
location: region:277561-279681:-1
so has part: feature:277561-279681:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:277561-279681:-1:exon

YMR006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PLB2
locus tag: YMR006C
EC number: 3.1.1.5
experiment: EXISTENCE:direct assay:GO:0004622 lysophospholipase activity [PMID:10497163]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10497163]
experiment: EXISTENCE:direct assay:GO:0006650 glycerophospholipid metabolic process [PMID:10497163]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0004622 lysophospholipase activity [PMID:10497163]
experiment: EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:10497163]
note: Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
codon start: 1
product: lysophospholipase
translation: MQLRNILQASSLISGLSLAADSSSTTGDGYAPSIIPCPSDDTSLVRNASGLSTAETDWLKKRDAYTKEALHSFLSRATSNFSDTSLLSTLFSSNSSNVPKIGIACSGGGYRAMLGGAGMIAAMDNRTDGANEHGLGGLLQSSTYLSGLSGGNWLTGTLAWNNWTSVQEIVDHMSESDSIWNITKSIVNPGGSNLTYTIERWESIVQEVQAKSDAGFNISLSDLWARALSYNFFPSLPDAGSALTWSSLRDVDVFKNGEMPLPITVADGRYPGTTVINLNATLFEFTPFEMGSWDPSLNAFTDVKYLGTNVTNGKPVNKDQCVSGYDNAGFVIATSASLFNEFSLEASTSTYYKMINSFANKYVNNLSQDDDDIAIYAANPFKDTEFVDRNYTSSIVDADDLFLVDGGEDGQNLPLVPLIKKERDLDVVFALDISDNTDESWPSGVCMTNTYERQYSKQGKGMAFPYVPDVNTFLNLGLTNKPTFFGCDAKNLTDLEYIPPLVVYIPNTKHSFNGNQSTLKMNYNVTERLGMIRNGFEAATMGNFTDDSNFLGCIGCAIIRRKQESLNATLPPECTKCFADYCWNGTLSTSANPELSGNSTYQSGAIASAISEATDGIPITALLGSSTSGNTTSNSTTSTSSNVTSNSNSSSNTTLNSNSSSSSISSSTARSSSSTANKANAAAISYANTNTLMSLLGAITALFGLI
SIO_010081: YMR006C
subclass of: SO_0000673
so part of: YMR006C
location: complement(277561..279681)
location: region:277561-279681:-1
so has part: feature:277561-279681:-1:exon

NP_013719.1
type: Protein
SIO_000068: ncbiprotein

S000004608
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:277561-279681:-1:exon

YMR007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR007W
so part of: sequence
location: <279960..>280340
location: region:279960-280340:1
so has part: feature:279960-280340:1:exon
subclass of: SO_0000010

855019
type: Gene
SIO_000068: ncbigene

position:279960:1
position: 279960
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280340:1
position: 280340
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:279960-280340:1:exon

YMR007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR007W
product: uncharacterized protein
transcript id: NM_001348864.1
SIO_010081: YMR007W
subclass of: SO_0000673
so part of: YMR007W
location: <279960..>280340
location: region:279960-280340:1
so has part: feature:279960-280340:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:279960-280340:1:exon

YMR007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR007W
note: hypothetical protein; conserved among S. cerevisiae strains; YMR007W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MRKKCPQGKKLLKKATRPFVGAFRRRIRAKKNLISQFGQTGCIGCDGKFSIGITIEKYVLNLVVRIIIVFALCRITELSVFDSSLRCKSRKTRLSKAARKKETDHFHEQCRYVEVKFGLQMAYLQS
SIO_010081: YMR007W
subclass of: SO_0000673
so part of: YMR007W
location: 279960..280340
location: region:279960-280340:1
so has part: feature:279960-280340:1:exon

NP_001335804.1
type: Protein
SIO_000068: ncbiprotein

S000004609
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:279960-280340:1:exon

YMR008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PLB1
locus tag: YMR008C
so part of: sequence
location: complement(<280590..>282584)
location: region:280590-282584:-1
so has part: feature:280590-282584:-1:exon
subclass of: SO_0000010

855020
type: Gene
SIO_000068: ncbigene

position:280590:-1
position: 280590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:282584:-1
position: 282584
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280590-282584:-1:exon

YMR008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PLB1
locus tag: YMR008C
product: lysophospholipase
transcript id: NM_001182504.1
SIO_010081: YMR008C
subclass of: SO_0000673
so part of: YMR008C
location: complement(<280590..>282584)
location: region:280590-282584:-1
so has part: feature:280590-282584:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280590-282584:-1:exon

YMR008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PLB1
locus tag: YMR008C
EC number: 3.1.1.5
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:25258318]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8051052|PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0042597 periplasmic space [PMID:8051052]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0004622 lysophospholipase activity [PMID:8051052]
experiment: EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:8051052]
experiment: EXISTENCE:mutant phenotype:GO:0036151 phosphatidylcholine acyl-chain remodeling [PMID:23501167]
note: Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication
codon start: 1
product: lysophospholipase
translation: MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVACSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINLNATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSSTLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSSIIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQRQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRHSFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNATLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASASASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI
SIO_010081: YMR008C
subclass of: SO_0000673
so part of: YMR008C
location: complement(280590..282584)
location: region:280590-282584:-1
so has part: feature:280590-282584:-1:exon

NP_013721.1
type: Protein
SIO_000068: ncbiprotein

S000004610
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280590-282584:-1:exon

YMR008C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR008C-A
so part of: sequence
location: complement(<283081..>283548)
location: region:283081-283548:-1
so has part: feature:283081-283548:-1:exon
subclass of: SO_0000010

65052913
type: Gene
SIO_000068: ncbigene

position:283081:-1
position: 283081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283548:-1
position: 283548
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:283081-283548:-1:exon

YMR008C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR008C-A
product: uncharacterized protein
transcript id: NM_001395039.1
SIO_010081: YMR008C-A
subclass of: SO_0000673
so part of: YMR008C-A
location: complement(<283081..>283548)
location: region:283081-283548:-1
so has part: feature:283081-283548:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:283081-283548:-1:exon

YMR008C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR008C-A
note: Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae
codon start: 1
product: uncharacterized protein
translation: MYDLLEQKFFVREIKFASAYYLRTGKALNNSKTPIFQRKHSLPAWLSSAVIITAPVSNDGSHSILFARKTLRMIMPMFSPLFNRSPDDCPSHLTATHIFQQFSAMLDYGQSTKEATNKRRLIKGSDLLVALDRNCIPSAPFVPEIALRKSGAVGS
SIO_010081: YMR008C-A
subclass of: SO_0000673
so part of: YMR008C-A
location: complement(283081..283548)
location: region:283081-283548:-1
so has part: feature:283081-283548:-1:exon

NP_001381969.1
type: Protein
SIO_000068: ncbiprotein

S000303813
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:283081-283548:-1:exon

YMR009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADI1
locus tag: YMR009W
so part of: sequence
location: <284102..>284641
location: region:284102-284641:1
so has part: feature:284102-284641:1:exon
subclass of: SO_0000010

855021
type: Gene
SIO_000068: ncbigene

position:284102:1
position: 284102
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:284641:1
position: 284641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284102-284641:1:exon

YMR009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADI1
locus tag: YMR009W
product: acireductone dioxygenase (Ni2+-requiring)
transcript id: NM_001182505.1
SIO_010081: YMR009W
subclass of: SO_0000673
so part of: YMR009W
location: <284102..>284641
location: region:284102-284641:1
so has part: feature:284102-284641:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:284102-284641:1:exon

YMR009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADI1
locus tag: YMR009W
EC number: 1.13.11.54
EC number: 1.13.11.53
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15938715]
experiment: EXISTENCE:mutant phenotype:GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity [PMID:15938715]
experiment: EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15938715|PMID:18625006]
note: Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant
codon start: 1
product: acireductone dioxygenase (Ni2+-requiring)
translation: MVKVYIHDNKVDSDYRAPHNSGTELSLDELAKLGVIYKYCANEEEVNEIARQREYKNRDVVNICEGSFKSEAEFNEKLATFYQEHLHEDEEIRYCLEGAGYFDVRDASTPENWIRCLVESGDLLILPPGIYHRFTLTTSNHIKALRLFKDEPKWQAINRSNQADSLPVRKDYIALINQY
SIO_010081: YMR009W
subclass of: SO_0000673
so part of: YMR009W
location: 284102..284641
location: region:284102-284641:1
so has part: feature:284102-284641:1:exon

NP_013722.1
type: Protein
SIO_000068: ncbiprotein

S000004611
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:284102-284641:1:exon

YMR010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CFS1
gene: ANY1
locus tag: YMR010W
gene synonym: CFS1
so part of: sequence
location: <285100..>286317
location: region:285100-286317:1
so has part: feature:285100-286317:1:exon
subclass of: SO_0000010

855022
type: Gene
SIO_000068: ncbigene

position:285100:1
position: 285100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286317:1
position: 286317
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285100-286317:1:exon

YMR010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CFS1
gene: ANY1
locus tag: YMR010W
gene synonym: CFS1
product: Any1p
transcript id: NM_001182506.1
SIO_010081: YMR010W
subclass of: SO_0000673
so part of: YMR010W
location: <285100..>286317
location: region:285100-286317:1
so has part: feature:285100-286317:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:285100-286317:1:exon

YMR010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CFS1
gene: ANY1
locus tag: YMR010W
gene synonym: CFS1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:28057802]
experiment: EXISTENCE:direct assay:GO:0032588 trans-Golgi network membrane [PMID:28057802]
experiment: EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:28057802]
experiment: EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:28057802]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:28057802]
note: Protein involved in phospholipid flippase function; null allele suppresses growth and membrane trafficking defects associated with all flippase null alleles; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the endosome and trans-Golgi network; non-essential gene
codon start: 1
product: Any1p
translation: MSTTGPLDATLIRDVAVATATKASYDMSDTLYSYLPKVDQFYIPEWLTMQFIANNLISFTPLFSYGTTIISIEKCKTALGFSIDICATMLIASILRISYYLITPYEITLLRQSLVMIFIQLILLRTSLKYRPDEYKYQNLTDVESLSHLIHDIWFEFFSCINRPKFLSEDWKNLIKSLSFTNLLKFSFKIFLAFFYKILKFFDPNFKRIGAFWQWDDDKNFWRFLALFATVQILVTFFISNILNWDSLAQGLGSIIGSLGLLVESLLPLPQIAILYKLKSVQGFKLILLVSWLCGDTLKITYLIFGAKNISALFVIFALFQMSLDFYIGGQYIYYRYYYPKLRHQHHPNDSNSPSDEDESEMYELDLFNTLQKDVEKALKQDSNDTSDSPQDDQVGKSQAQAVTL
SIO_010081: YMR010W
subclass of: SO_0000673
so part of: YMR010W
location: 285100..286317
location: region:285100-286317:1
so has part: feature:285100-286317:1:exon

NP_013723.1
type: Protein
SIO_000068: ncbiprotein

S000004612
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:285100-286317:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1310; Autonomously Replicating Sequence
so part of: sequence
location: 286835..286951
location: region:286835-286951:1
so has part: feature:286835-286951:1:region

S000118370
type: SGD
SIO_000068: sgd

position:286835:1
position: 286835
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:286951:1
position: 286951
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286835-286951:1:region

YMR011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HXT2
locus tag: YMR011W
so part of: sequence
location: <288079..>289704
location: region:288079-289704:1
so has part: feature:288079-289704:1:exon
subclass of: SO_0000010

855023
type: Gene
SIO_000068: ncbigene

position:288079:1
position: 288079
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:289704:1
position: 289704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288079-289704:1:exon

YMR011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HXT2
locus tag: YMR011W
product: hexose transporter HXT2
transcript id: NM_001182507.1
SIO_010081: YMR011W
subclass of: SO_0000673
so part of: YMR011W
location: <288079..>289704
location: region:288079-289704:1
so has part: feature:288079-289704:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288079-289704:1:exon

YMR011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HXT2
locus tag: YMR011W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005355 glucose transmembrane transporter activity [PMID:12702270]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10191260|PMID:17507646|PMID:24124599]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]
experiment: EXISTENCE:mutant phenotype:GO:1904659 glucose transmembrane transport [PMID:2233722]
note: High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose
codon start: 1
product: hexose transporter HXT2
translation: MSEFATSRVESGSQQTSIHSTPIVQKLETDESPIQTKSEYTNAELPAKPIAAYWTVICLCLMIAFGGFVFGWDTGTISGFVNQTDFKRRFGQMKSDGTYYLSDVRTGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGMGVGGIAVLSPTLISETAPKHIRGTCVSFYQLMITLGIFLGYCTNYGTKDYSNSVQWRVPLGLNFAFAIFMIAGMLMVPESPRFLVEKGRYEDAKRSLAKSNKVTIEDPSIVAEMDTIMANVETERLAGNASWGELFSNKGAILPRVIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMKDSFQTSIVLGIVNFASTFVALYTVDKFGRRKCLLGGSASMAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVMIVFTCLFIFFFAISWAPIAYVIVAESYPLRVKNRAMAIAVGANWIWGFLIGFFTPFITSAIGFSYGYVFMGCLVFSFFYVFFFVCETKGLTLEEVNEMYVEGVKPWKSGSWISKEKRVSEE
SIO_010081: YMR011W
subclass of: SO_0000673
so part of: YMR011W
location: 288079..289704
location: region:288079-289704:1
so has part: feature:288079-289704:1:exon

NP_013724.1
type: Protein
SIO_000068: ncbiprotein

S000004613
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288079-289704:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(290049..290224)
location: region:290049-290224:-1
so has part: feature:290049-290224:-1:region

S000007117
type: SGD
SIO_000068: sgd

position:290049:-1
position: 290049
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:290224:-1
position: 290224
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290049-290224:-1:region

YNCM0010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0010W
so part of: sequence
location: 290801..290872
location: region:290801-290872:1
so has part: feature:290801-290872:1:exon
subclass of: SO_0000663

855024
type: Gene
SIO_000068: ncbigene

position:290801:1
position: 290801
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:290872:1
position: 290872
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290801-290872:1:exon

YNCM0010W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0010W
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCM0010W
subclass of: SO_0000673
so part of: YNCM0010W
location: 290801..290872
location: region:290801-290872:1
so has part: feature:290801-290872:1:exon

S000006560
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:290801-290872:1:exon

YMR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TIF31
gene: CLU1
locus tag: YMR012W
gene synonym: TIF31
so part of: sequence
location: <291134..>294967
location: region:291134-294967:1
so has part: feature:291134-294967:1:exon
subclass of: SO_0000010

855025
type: Gene
SIO_000068: ncbigene

position:291134:1
position: 291134
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:294967:1
position: 294967
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:291134-294967:1:exon

YMR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TIF31
gene: CLU1
locus tag: YMR012W
gene synonym: TIF31
product: translation initiation factor 3 subunit CLU1
transcript id: NM_001182508.1
SIO_010081: YMR012W
subclass of: SO_0000673
so part of: YMR012W
location: <291134..>294967
location: region:291134-294967:1
so has part: feature:291134-294967:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:291134-294967:1:exon

YMR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TIF31
gene: CLU1
locus tag: YMR012W
gene synonym: TIF31
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7798228]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
note: Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough
codon start: 1
product: translation initiation factor 3 subunit CLU1
translation: MSEKKEEVKNATVKVTVKLPKEDNHSHNTKHLKKTQSSKNNDISFEIGKESKIQTVLDVLAMIPSSKYLTNVGLKTIEGDSQLSDEMSIKEIVGEKSELKLQLILKPYSAREALKHVITVRDFIGFAQETSDGLSEFAISTGSSFSSLPLGPIKERSKQEEKDEKSDPEEKKNTFKDVTDEEKLKFNEMVHEVFSSFKNSSINKLLTSESNIITPCVRSLSFAPYNPVPPFYRSKGHLFYLQIVTLEGESFYITAIPSGFYVNKSNSTKFDPSPKENTDENAHSSLIYYSLFDLIASRSKKFISHVQAFEKKLSALDSTSYVRPSNTFLHKPWFVSSLPPNNPDYLRLQTAALDTTPERNFNDEFQAIKDLTTSTLQDRIEMERLFSKVVHEFSVTAASGAMSIFYSDFVAMNPESPTRDQIFLKDNIFYSYVSDVSGNYEGKGGDEAAIAASNQDLKTINILNRLHMHEVRYLLTTVVEFAGRRILAQTPVPGLLATMGNKIVKDANTGEEVTEDFVNDINVKYGLDEGLGKIVYDADFDSVLEKKFVKAFHLKKHKVNGTELAFSSQSKGIVGFDKRRYILDLANTYPLDINFARQNFDNIEETGNRYPHRQTLLRPELVEKWWNNKVEKEGVEFEKAYEENLFSYNPDAYQVEGIEDANVDEMSNYLQKEVIPSVIQDYLSGNLSTPYNGEHLADTLHKNGINMRYLGKIIELSQKELDSQIVHYEQNLKAVEQDNKEYEDWEKSYLQKIENMIKERQAKINKLVQEGKEVPKELTEDLKLNDEEIKKPTDGKPVVVAYDELVPLIKISELEIVSRSLKHVLKDLSKDVPVFLVPSLVAYVFNMLVGINYNADPKPEPVDEFYPVNKCSFAKLTRSELLEAVSKQAFLRFRHQLPSNWIEAYMENPFTLIRSVSYKFGIQLLNKEYFFTREQLESYKQSLDKKIRNKFVEPPTTFSLSDLTIIPRVKFSEYTSSVSEEFWAQGASMINEDKQSALTLLAQSITVLEDVNNILHPAVAEKYLSLSAIYNKLALYPEAIAFCRKACTIYERVSGIDSFEMMRALTNLAILEFSNESPYNATVVYNRLAEILKVYELPKIHHPAPTSIFNHLEQLALGVQDTKLAIEVLGQLSSYVVELEGKDSLAYGYTESRLGNLFAALKDFHRALEHITVTQGIFTKQLGMNHTHSAQSRQWVNGLSSLIMDLKQKKQLAQDQMSTTGSNSAGHKKTNHRQKKDDVKPELANKSVDELLTFIEGDSSNSKSKNKTNNKKKHGKK
SIO_010081: YMR012W
subclass of: SO_0000673
so part of: YMR012W
location: 291134..294967
location: region:291134-294967:1
so has part: feature:291134-294967:1:exon

NP_013725.1
type: Protein
SIO_000068: ncbiprotein

S000004614
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:291134-294967:1:exon

YMR013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC59
locus tag: YMR013C
so part of: sequence
location: complement(<295179..>296738)
location: region:295179-296738:-1
so has part: feature:295179-296738:-1:exon
subclass of: SO_0000010

855026
type: Gene
SIO_000068: ncbigene

position:295179:-1
position: 295179
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296738:-1
position: 296738
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:295179-296738:-1:exon

YMR013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC59
locus tag: YMR013C
product: dolichol kinase
transcript id: NM_001182509.1
SIO_010081: YMR013C
subclass of: SO_0000673
so part of: YMR013C
location: complement(<295179..>296738)
location: region:295179-296738:-1
so has part: feature:295179-296738:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:295179-296738:-1:exon

YMR013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC59
locus tag: YMR013C
EC number: 2.7.1.108
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:2657387]
experiment: EXISTENCE:genetic interaction:GO:0004168 dolichol kinase activity [PMID:12213788]
experiment: EXISTENCE:genetic interaction:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:12213788]
experiment: EXISTENCE:mutant phenotype:GO:0004168 dolichol kinase activity [PMID:2657387|PMID:12213788]
experiment: EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:2657387]
experiment: EXISTENCE:mutant phenotype:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:12213788|PMID:1323123]
note: Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
codon start: 1
product: dolichol kinase
translation: MVAIIPHASFTTIKLTQKTEGSQMPTEEICKINMRTRKFDVGGNSRDFECFYSNFVQTVILLGTFFYCVERLQPWSIVTADISYKQIFVNVFVVCLIMVGLIFTKYWQHGYKSLPKFDTIYSLYLPFMVSLLFDTSSTVINTILILSVLNSYRWRTQLVVIILQLCLIFFNFEAGDRLKNIISIVINSLLSLILKYIGQLKSLDNIDSNLFSILLTNILYVSEAGTVHFRILKGIILALTTIISINYVLKKVMHFKPFMLSISFAIGLPLFANTFIHLEDGENPLLWLVKYILESTIRQKILFAWSSILILSIPSILIEKDSLSLNTSRKLWHFIIFLLIIPSFQMDSNFVKIALSGTIPVFLSIEYIRFQNLPPLGSAIELQLRRFADDRDHSGPLIISYLYLLFGISTPLLMNNSPMGLIGLGIGDSLASIIGKRYGRIRWKGTQKTLEGTLAFIVTSFIVCLVLLRFDKAAIFNHLTTLQLLTLCTLSGVLEGNSVLNDNILIPAFMMICEKLITL
SIO_010081: YMR013C
subclass of: SO_0000673
so part of: YMR013C
location: complement(295179..296738)
location: region:295179-296738:-1
so has part: feature:295179-296738:-1:exon

NP_013726.1
type: Protein
SIO_000068: ncbiprotein

S000004615
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:295179-296738:-1:exon

YNCM0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR78
locus tag: YNCM0011W
so part of: sequence
location: 297278..297364
location: region:297278-297364:1
so has part: feature:297278-297364:1:exon
subclass of: SO_0000578

9164958
type: Gene
SIO_000068: ncbigene

position:297278:1
position: 297278
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:297364:1
position: 297364
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297278-297364:1:exon

YNCM0011W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR78
locus tag: YNCM0011W
product: SNR78
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:18726517|PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:18726517|PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U2421
transcript id: NR_132237.1
SIO_010081: YNCM0011W
subclass of: SO_0000673
so part of: YNCM0011W
location: 297278..297364
location: region:297278-297364:1
so has part: feature:297278-297364:1:exon

S000007312
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:297278-297364:1:exon

YNCM0012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR77
locus tag: YNCM0012W
so part of: sequence
location: 297506..297593
location: region:297506-297593:1
so has part: feature:297506-297593:1:exon
subclass of: SO_0000578

9164954
type: Gene
SIO_000068: ncbigene

position:297506:1
position: 297506
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:297593:1
position: 297593
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297506-297593:1:exon

YNCM0012W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR77
locus tag: YNCM0012W
product: SNR77
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position U578
transcript id: NR_132238.1
SIO_010081: YNCM0012W
subclass of: SO_0000673
so part of: YNCM0012W
location: 297506..297593
location: region:297506-297593:1
so has part: feature:297506-297593:1:exon

S000007311
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:297506-297593:1:exon

YNCM0013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR76
locus tag: YNCM0013W
so part of: sequence
location: 297725..297833
location: region:297725-297833:1
so has part: feature:297725-297833:1:exon
subclass of: SO_0000578

9164962
type: Gene
SIO_000068: ncbigene

position:297725:1
position: 297725
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:297833:1
position: 297833
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297725-297833:1:exon

YNCM0013W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR76
locus tag: YNCM0013W
product: SNR76
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position C2197
transcript id: NR_132239.1
SIO_010081: YNCM0013W
subclass of: SO_0000673
so part of: YNCM0013W
location: 297725..297833
location: region:297725-297833:1
so has part: feature:297725-297833:1:exon

S000007310
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:297725-297833:1:exon

YNCM0014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR75
locus tag: YNCM0014W
so part of: sequence
location: 297918..298006
location: region:297918-298006:1
so has part: feature:297918-298006:1:exon
subclass of: SO_0000578

9164956
type: Gene
SIO_000068: ncbigene

position:297918:1
position: 297918
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:298006:1
position: 298006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297918-298006:1:exon

YNCM0014W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR75
locus tag: YNCM0014W
product: SNR75
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position G2288
transcript id: NR_132240.1
SIO_010081: YNCM0014W
subclass of: SO_0000673
so part of: YNCM0014W
location: 297918..298006
location: region:297918-298006:1
so has part: feature:297918-298006:1:exon

S000007309
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:297918-298006:1:exon

YNCM0015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR74
locus tag: YNCM0015W
so part of: sequence
location: 298138..298225
location: region:298138-298225:1
so has part: feature:298138-298225:1:exon
subclass of: SO_0000578

9164964
type: Gene
SIO_000068: ncbigene

position:298138:1
position: 298138
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:298225:1
position: 298225
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298138-298225:1:exon

YNCM0015W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR74
locus tag: YNCM0015W
product: SNR74
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position A28
transcript id: NR_132241.1
SIO_010081: YNCM0015W
subclass of: SO_0000673
so part of: YNCM0015W
location: 298138..298225
location: region:298138-298225:1
so has part: feature:298138-298225:1:exon

S000007308
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298138-298225:1:exon

YNCM0016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR73
locus tag: YNCM0016W
so part of: sequence
location: 298307..298412
location: region:298307-298412:1
so has part: feature:298307-298412:1:exon
subclass of: SO_0000578

9164963
type: Gene
SIO_000068: ncbigene

position:298307:1
position: 298307
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:298412:1
position: 298412
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298307-298412:1:exon

YNCM0016W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR73
locus tag: YNCM0016W
product: SNR73
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position C2959
transcript id: NR_132242.1
SIO_010081: YNCM0016W
subclass of: SO_0000673
so part of: YNCM0016W
location: 298307..298412
location: region:298307-298412:1
so has part: feature:298307-298412:1:exon

S000007307
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298307-298412:1:exon

YNCM0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR72
locus tag: YNCM0017W
so part of: sequence
location: 298554..298651
location: region:298554-298651:1
so has part: feature:298554-298651:1:exon
subclass of: SO_0000578

9164953
type: Gene
SIO_000068: ncbigene

position:298554:1
position: 298554
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:298651:1
position: 298651
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298554-298651:1:exon

YNCM0017W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR72
locus tag: YNCM0017W
product: SNR72
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:9891049]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:9891049]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:9891049]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A876
transcript id: NR_132243.1
SIO_010081: YNCM0017W
subclass of: SO_0000673
so part of: YNCM0017W
location: 298554..298651
location: region:298554-298651:1
so has part: feature:298554-298651:1:exon

S000007306
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298554-298651:1:exon

YMR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUD22
locus tag: YMR014W
so part of: sequence
location: <298868..>300427
location: region:298868-300427:1
so has part: feature:298868-300427:1:exon
subclass of: SO_0000010

855028
type: Gene
SIO_000068: ncbigene

position:298868:1
position: 298868
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300427:1
position: 300427
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298868-300427:1:exon

YMR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUD22
locus tag: YMR014W
product: Bud22p
transcript id: NM_001182510.1
SIO_010081: YMR014W
subclass of: SO_0000673
so part of: YMR014W
location: <298868..>300427
location: region:298868-300427:1
so has part: feature:298868-300427:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298868-300427:1:exon

YMR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUD22
locus tag: YMR014W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11452010]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:19806183]
experiment: EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:20498295]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:20498295|PMID:19806183]
note: Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern
codon start: 1
product: Bud22p
translation: MPSESSVSIYKLDQLEYQYHYLTKSLQKFEPRYPKTAKLYNCIGKKNKKKIEKLLNSLELKTLDKELDESYSKLLNNKIHYYETHLSKCIKEQIQKISKKNSSKVKDAQKNKSPSIDIEKMLATQLSLDDLALFMTRFRLIKILHQRIKQKSKKIEGDTNNKTWLNNNDYSGYINDKTSKWNPSNIWNEVITKLPSCEKLNALIGQSKIVQNLTESFDLSICLIFGFDVSAMKAKKYGAREKTANANQTHSNIDYDTDDGNEKNAIDSKSNAIGAQTQSNKETTSDNEDLLIKEYEGMLGSSGDEGEGGGYLNPNINYNEVTDEEPSEASSDEDDSDERFSDSEENEPRRKKPKLHNLPELMAGYYSGNDTEEESDEDNKNVKGKKKKRDTAEDRTAREQMSNEPKRKNRRGQRARRKIWEKKYGSQAKHVQRELEKEMEDRKQRQIEYEARVAKREAKAASLEASRSREREDRRTETNNKKEKESASTGEEHPSWIAKRLAEEKLQKAKFEGKKIKFD
SIO_010081: YMR014W
subclass of: SO_0000673
so part of: YMR014W
location: 298868..300427
location: region:298868-300427:1
so has part: feature:298868-300427:1:exon

NP_013727.1
type: Protein
SIO_000068: ncbiprotein

S000004616
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298868-300427:1:exon

YMR015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP61
gene: ERG5
locus tag: YMR015C
gene synonym: CYP61
so part of: sequence
location: complement(<300869..>302485)
location: region:300869-302485:-1
so has part: feature:300869-302485:-1:exon
subclass of: SO_0000010

855029
type: Gene
SIO_000068: ncbigene

position:300869:-1
position: 300869
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:302485:-1
position: 302485
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:300869-302485:-1:exon

YMR015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP61
gene: ERG5
locus tag: YMR015C
gene synonym: CYP61
product: C-22 sterol desaturase
transcript id: NM_001182511.1
SIO_010081: YMR015C
subclass of: SO_0000673
so part of: YMR015C
location: complement(<300869..>302485)
location: region:300869-302485:-1
so has part: feature:300869-302485:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:300869-302485:-1:exon

YMR015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP61
gene: ERG5
locus tag: YMR015C
gene synonym: CYP61
EC number: 1.14.19.41
experiment: EXISTENCE:direct assay:GO:0000249 C-22 sterol desaturase activity [PMID:8543054]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8543054]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8635732]
note: C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
codon start: 1
product: C-22 sterol desaturase
translation: MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE
SIO_010081: YMR015C
subclass of: SO_0000673
so part of: YMR015C
location: complement(300869..302485)
location: region:300869-302485:-1
so has part: feature:300869-302485:-1:exon

NP_013728.1
type: Protein
SIO_000068: ncbiprotein

S000004617
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:300869-302485:-1:exon

YMR016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOK2
locus tag: YMR016C
so part of: sequence
location: complement(<303236..>305593)
location: region:303236-305593:-1
so has part: feature:303236-305593:-1:exon
subclass of: SO_0000010

855030
type: Gene
SIO_000068: ncbigene

position:303236:-1
position: 303236
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:305593:-1
position: 305593
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:303236-305593:-1:exon

YMR016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOK2
locus tag: YMR016C
product: Sok2p
transcript id: NM_001182512.1
SIO_010081: YMR016C
subclass of: SO_0000673
so part of: YMR016C
location: complement(<303236..>305593)
location: region:303236-305593:-1
so has part: feature:303236-305593:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:303236-305593:-1:exon

YMR016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOK2
locus tag: YMR016C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11046133|PMID:8524252]
note: Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
codon start: 1
product: Sok2p
translation: MPIGNPINTNDIKSNRMRQESNMSAVSNSESTIGQSTQQQQQQQQYLGQSVQPLMPVSYQYVVPEQWPYPQYYQQPQSQSQQQLQSQPQMYQVQESFQSSGSDSNASNPPSTSVGVPSNATATALPNGSAITTKKSNNSTNISNNVPYYYYFPQMQAQQSMAYSYPQAYYYYPANGDGTTNGATPSVTSNQVQNPNLEKTYSTFEQQQQHQQQQQLQAQTYPAQPPKIGNAFSKFSKSGPPSDSSSGSMSPNSNRTSRNSNSISSLAQQPPMSNYPQPSTYQYPGFHKTSSIPNSHSPIPPRSLTTPTQGPTSQNGPLSYNLPQVGLLPPQQQQQVSPLYDGNSITPPVKPSTDQETYLTANRHGVSDQQYDSMAKTMNSFQTTTIRHPMPLIATTNATGSNTSGTSASIIRPRVTTTMWEDEKTLCYQVEANGISVVRRADNDMVNGTKLLNVTKMTRGRRDGILKAEKIRHVVKIGSMHLKGVWIPFERALAIAQREKIADYLYPLFIRDIQSVLKQNNPSNDSSSSSSSTGIKSISPRTYYQPINNYQNPNGPSNISAAQLTYSSMNLNNKIIPNNSIPAVSTIAAGEKPLKKCTMPNSNQLEGHTITNLQTLSATMPMKQQLMGNIASPLSYPRNATMNSASTLGITPADSKPLTPSPTTTNTNQSSESNVGSIHTGITLPRVESESASHSKWSKEADSGNTVPDNQTLKEPRSSQLPISALTSTDTDKIKTSTSDEATQPNEPSEAEPVKESESSKSQVDGAGDVSNEEIAADDTKKQEK
SIO_010081: YMR016C
subclass of: SO_0000673
so part of: YMR016C
location: complement(303236..305593)
location: region:303236-305593:-1
so has part: feature:303236-305593:-1:exon

NP_013729.1
type: Protein
SIO_000068: ncbiprotein

S000004618
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:303236-305593:-1:exon

YMR017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DBI9
gene: SPO20
locus tag: YMR017W
gene synonym: DBI9
so part of: sequence
location: <307489..>308682
location: region:307489-308682:1
so has part: feature:307489-308682:1:exon
subclass of: SO_0000010

855031
type: Gene
SIO_000068: ncbigene

position:307489:1
position: 307489
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:308682:1
position: 308682
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307489-308682:1:exon

YMR017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DBI9
gene: SPO20
locus tag: YMR017W
gene synonym: DBI9
product: Spo20p
transcript id: NM_001182513.1
SIO_010081: YMR017W
subclass of: SO_0000673
so part of: YMR017W
location: <307489..>308682
location: region:307489-308682:1
so has part: feature:307489-308682:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307489-308682:1:exon

YMR017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DBI9
gene: SPO20
locus tag: YMR017W
gene synonym: DBI9
experiment: EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:14742704]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:14742704]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14742704]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14742704]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:10924463]
experiment: EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:14742704|PMID:27480805]
experiment: EXISTENCE:mutant phenotype:GO:0005628 prospore membrane [PMID:9425151]
experiment: EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:9425151]
experiment: EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:10924463]
note: Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog
codon start: 1
product: Spo20p
translation: MGFRKILASKSHHSRHHNQHHKNLKLQNHRYVLISNITGSHETKYLSPFRMDNCSGSRRRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTSDDKCVSYEVPERDGLATISLEEVFPKSNRCQIPEENLGETDSVIHRDLGNFANENDYPQWRKVESQYNLENVQPEEDEIVDRLRSEIRSTKLKSVKTTSRTLEKAIEARCTGKRVLQQLSCQSNQLTKIESNCDMLKIQSNVADRKIDELAHENRSLLALKSPNPFRKKREREKRDQIYNLKLKHRHLQQETMKRAQDSDKNLAINLSSEYGRYGQGVERQRILRDAQKYQFEADEEDNQMEIDLYGNLEQIKAVSGDLKIMAHAFGREFEAQNTRMFDIENNVQQADNALQAKRYRLEKVIGKRW
SIO_010081: YMR017W
subclass of: SO_0000673
so part of: YMR017W
location: 307489..308682
location: region:307489-308682:1
so has part: feature:307489-308682:1:exon

NP_013730.1
type: Protein
SIO_000068: ncbiprotein

S000004619
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307489-308682:1:exon

YMR018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEX9
locus tag: YMR018W
so part of: sequence
location: <310208..>311752
location: region:310208-311752:1
so has part: feature:310208-311752:1:exon
subclass of: SO_0000010

855032
type: Gene
SIO_000068: ncbigene

position:310208:1
position: 310208
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:311752:1
position: 311752
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310208-311752:1:exon

YMR018W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEX9
locus tag: YMR018W
product: Pex9p
transcript id: NM_001182514.1
SIO_010081: YMR018W
subclass of: SO_0000673
so part of: YMR018W
location: <310208..>311752
location: region:310208-311752:1
so has part: feature:310208-311752:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310208-311752:1:exon

YMR018W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEX9
locus tag: YMR018W
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:27678487]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:27678487]
experiment: EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:27663510|PMID:27678487]
experiment: EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:27663510]
experiment: EXISTENCE:physical interaction:GO:0016558 protein import into peroxisome matrix [PMID:27678487]
note: Peroxisomal membrane signal receptor for peroxisomal matrix proteins; oleate-inducible condition-specific import receptor for a subset of PTS1-containing matrix proteins; localizes to both the cytosol and the peroxisomal membrane; similar to human PEX5Rp, a peroxin protein 5 related protein; paralog of Pex5p
codon start: 1
product: Pex9p
translation: MNEVTCSITGDNPIHKINNGLGLKWNNLGKFSDFQTNDSAARDARTIDYIFTNCQTGSSIGKIDFRAALPADKSQHSGVSEKEFSRLENQWSKEFSCFPKNKNADVTKPSRNKHEKRSANLHNRYFAQYYSTAYQQNRIYPCRISYNEHSSVSNGWEFQFKSIENQLLNELKIENNVEEKTVGYEYVAEYEETIDFMHMLSSVPQTYQFLKSNIYITERDPYKIGCVLMDNGSNLNEVVMAFEAAISQDPSHINAWLKLGIVNFENESESNGELALRNCLNLDPNNTIALENLAIHHINQQNESESLKLFHKWILSKFSKVFQPSAGENKDSINKIPKKAHLAHILESLLNMGIEKKDQYDIYSVLSILYYSDQKIKQSQKCLEFLLLEKPNNGTIWNRYGAILANTKSYHSAINAYNKCKQLRPNFTRVRYNLAIAYMNKGDYVKASKMLIEVILLRSKGYEHNKAKMQNKFMQNLKNALIASKNFDSLDLINGSHNTESLISTLKAIYNKMD
SIO_010081: YMR018W
subclass of: SO_0000673
so part of: YMR018W
location: 310208..311752
location: region:310208-311752:1
so has part: feature:310208-311752:1:exon

NP_013731.1
type: Protein
SIO_000068: ncbiprotein

S000004620
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310208-311752:1:exon

YMR019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STB4
locus tag: YMR019W
so part of: sequence
location: <312156..>315005
location: region:312156-315005:1
so has part: feature:312156-315005:1:exon
subclass of: SO_0000010

855033
type: Gene
SIO_000068: ncbigene

position:312156:1
position: 312156
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315005:1
position: 315005
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312156-315005:1:exon

YMR019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STB4
locus tag: YMR019W
product: Stb4p
transcript id: NM_001182515.1
SIO_010081: YMR019W
subclass of: SO_0000673
so part of: YMR019W
location: <312156..>315005
location: region:312156-315005:1
so has part: feature:312156-315005:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:312156-315005:1:exon

YMR019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STB4
locus tag: YMR019W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
note: Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay
codon start: 1
product: Stb4p
translation: MSINHEIYYILVFEHRSVAIKLIIVVIVLLQFFLARSRQIDRTWAHTNRKERFREMTAIGNTDDALDTSTAASKENGKGRLRVQKACELCKKRKVKCDGNNPCLNCSKHQKECRYDFKATNRKRRRRQVASAVRDVSKTYAETSESFPRDLLSKSNIIINAPSDGVSSSASNSPNPNSHYHHISSTLPFMSGRPNHTFHSGSNLNGENNNNSFPEDHMAKLLLQLSSKLGNTTKESSIRTTRTNASDVNANPTVVNMKNSQEDCDTNHRSAICDSAEALHNNNINSKENKIINSQITNTVNDHFESPWQTFSLDKYRFHRRYQNILPYYLGVSILKDLSPQTIEYAKLKRPRVQNYGWNLSGGHYLKYKGDFRSQEKNIRHESKFFDFDDPVHLSLINKLLRYYFDEINPVFSIIHEATFWQQYNNKFLRQGKQNNSSANLFTSMLYLILSTTLRFREGHLDGQKGQGTYSNTSLNITFEEKSILIKKPSIEENLFKYAYLIINTLTFEWESFELIQSWLLITFYFRTCYRQTACWNALSQAVNMCNGMSLYLNKFPEIHSTYDESKAWHCFWCCFIMDKLISFQMGRFYQLSLPASEMCEQMNLVKSKKFLQEEDDWFHEETFQMLDLSIIVTQFLKRDAQDLNLNETVQLRSQLGQWYDTFIVGSQTNAYDDNYRYFYQVQPFMTYLDIRLTFEVRQLFCLIAPSSTANNKSLEYVVDTELLISHCQMAIENLAEITRSNLFFVPWWLNLSQLFTVNLICIIYLHAGIAVTQNKAIMQSCQEIWRTLECSKPKNRPSMLPECLWCLKMLNHMFCIRLRDSALQLEATLGTDHGDDTPNRNKFEQFKKVGDNDADVEVDAGEREENADERQENPHNNSKRVPLATRSHNTTNFDGSIAISPESAVANLGTDTGLPSDVLDTVSKIGNSPNVFDDDLFSNLLWFDQNFA
SIO_010081: YMR019W
subclass of: SO_0000673
so part of: YMR019W
location: 312156..315005
location: region:312156-315005:1
so has part: feature:312156-315005:1:exon

NP_013732.1
type: Protein
SIO_000068: ncbiprotein

S000004621
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:312156-315005:1:exon

YMR020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMS1
locus tag: YMR020W
so part of: sequence
location: <315377..>316903
location: region:315377-316903:1
so has part: feature:315377-316903:1:exon
subclass of: SO_0000010

855034
type: Gene
SIO_000068: ncbigene

position:315377:1
position: 315377
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316903:1
position: 316903
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:315377-316903:1:exon

YMR020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMS1
locus tag: YMR020W
product: polyamine oxidase
transcript id: NM_001182516.1
SIO_010081: YMR020W
subclass of: SO_0000673
so part of: YMR020W
location: <315377..>316903
location: region:315377-316903:1
so has part: feature:315377-316903:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:315377-316903:1:exon

YMR020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMS1
locus tag: YMR020W
EC number: 1.5.3.17
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0046592 polyamine oxidase activity [PMID:21067138]
experiment: EXISTENCE:genetic interaction:GO:0046208 spermine catabolic process [PMID:12586697]
experiment: EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]
experiment: EXISTENCE:mutant phenotype:GO:0046208 spermine catabolic process [PMID:12586697]
experiment: EXISTENCE:mutant phenotype:GO:0046592 polyamine oxidase activity [PMID:11154694]
note: Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
codon start: 1
product: polyamine oxidase
translation: MNTVSPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK
SIO_010081: YMR020W
subclass of: SO_0000673
so part of: YMR020W
location: 315377..316903
location: region:315377-316903:1
so has part: feature:315377-316903:1:exon

NP_013733.1
type: Protein
SIO_000068: ncbiprotein

S000004622
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:315377-316903:1:exon

YMR021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CUA1
gene: MAC1
locus tag: YMR021C
gene synonym: CUA1
so part of: sequence
location: complement(<317165..>318418)
location: region:317165-318418:-1
so has part: feature:317165-318418:-1:exon
subclass of: SO_0000010

855035
type: Gene
SIO_000068: ncbigene

position:317165:-1
position: 317165
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:318418:-1
position: 318418
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:317165-318418:-1:exon

YMR021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CUA1
gene: MAC1
locus tag: YMR021C
gene synonym: CUA1
product: Mac1p
transcript id: NM_001182517.1
SIO_010081: YMR021C
subclass of: SO_0000673
so part of: YMR021C
location: complement(<317165..>318418)
location: region:317165-318418:-1
so has part: feature:317165-318418:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:317165-318418:-1:exon

YMR021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CUA1
gene: MAC1
locus tag: YMR021C
gene synonym: CUA1
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:9867833]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8262047]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9159110]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10887177]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:8262047|PMID:9211922]
experiment: EXISTENCE:mutant phenotype:GO:0045732 positive regulation of protein catabolic process [PMID:12011036]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8262047]
note: Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS
codon start: 1
product: Mac1p
translation: MIIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPSPMAIRDAILVDSTSQSTEYENGAQIEGDCCSAMNQQPILFVRASAVRKARMINGKLHILMEEGFTAHEPKDISTFTDDGNKYITETEFLRKHSPKAPATGTISPDSTKSSSSSEKKERSRLQQEPIRHFSNCCKKDKSQNPASNGKTNKAPSDDIFTPYGSLESTSAFNDILQENYNSSVPGAHDSSETLTPQSTTTIAAPHSSDVASKVEVLTHKGIFLSTQCSCEDESCPCVNCLIHRSEEELNSYIQQSGVPLTNIGEAQITDKMMDYLDDCKCTDKECICPPDNCTCDGCFSHSTNIIPFEKFFFYGILNARLTRKTQIKFKGKLVPSKYWWDFLKLQVPLMTDAQLELLDIHAWFQKLVSNYAPHLSDATTS
SIO_010081: YMR021C
subclass of: SO_0000673
so part of: YMR021C
location: complement(317165..318418)
location: region:317165-318418:-1
so has part: feature:317165-318418:-1:exon

NP_013734.1
type: Protein
SIO_000068: ncbiprotein

S000004623
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:317165-318418:-1:exon

YMR022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DER2
alternative label: QRI8
gene: UBC7
locus tag: YMR022W
gene synonym: DER2; QRI8
so part of: sequence
location: <318680..>319177
location: region:318680-319177:1
so has part: feature:318680-319177:1:exon
subclass of: SO_0000010

855036
type: Gene
SIO_000068: ncbigene

position:318680:1
position: 318680
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:319177:1
position: 319177
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318680-319177:1:exon

YMR022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DER2
alternative label: QRI8
gene: UBC7
locus tag: YMR022W
gene synonym: DER2; QRI8
product: E2 ubiquitin-conjugating protein UBC7
transcript id: NM_001182518.1
SIO_010081: YMR022W
subclass of: SO_0000673
so part of: YMR022W
location: <318680..>319177
location: region:318680-319177:1
so has part: feature:318680-319177:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:318680-319177:1:exon

YMR022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DER2
alternative label: QRI8
gene: UBC7
locus tag: YMR022W
gene synonym: DER2; QRI8
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9172777]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9388185]
experiment: EXISTENCE:direct assay:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:12105183]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:8641272]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15643069]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:8641272|PMID:8781238]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]
note: Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
codon start: 1
product: E2 ubiquitin-conjugating protein UBC7
translation: MSKTAQKRLLKELQQLIKDSPPGIVAGPKSENNIFIWDCLIQGPPDTPYADGVFNAKLEFPKDYPLSPPKLTFTPSILHPNIYPNGEVCISILHSPGDDPNMYELAEERWSPVQSVEKILLSVMSMLSEPNIESGANIDACILWRDNRPEFERQVKLSILKSLGF
SIO_010081: YMR022W
subclass of: SO_0000673
so part of: YMR022W
location: 318680..319177
location: region:318680-319177:1
so has part: feature:318680-319177:1:exon

NP_013735.1
type: Protein
SIO_000068: ncbiprotein

S000004624
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:318680-319177:1:exon

YMR023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PET53
gene: MSS1
locus tag: YMR023C
gene synonym: PET53
so part of: sequence
location: complement(<319437..>321017)
location: region:319437-321017:-1
so has part: feature:319437-321017:-1:exon
subclass of: SO_0000010

855037
type: Gene
SIO_000068: ncbigene

position:319437:-1
position: 319437
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321017:-1
position: 321017
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319437-321017:-1:exon

YMR023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PET53
gene: MSS1
locus tag: YMR023C
gene synonym: PET53
product: Mss1p
transcript id: NM_001182519.1
SIO_010081: YMR023C
subclass of: SO_0000673
so part of: YMR023C
location: complement(<319437..>321017)
location: region:319437-321017:-1
so has part: feature:319437-321017:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:319437-321017:-1:exon

YMR023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PET53
gene: MSS1
locus tag: YMR023C
gene synonym: PET53
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11604502]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0070899 mitochondrial tRNA wobble uridine modification [PMID:15509579]
note: Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
codon start: 1
product: Mss1p
translation: MNSASFLQSRLISRSFLVRRSLKRYSGLAKPYTFQQPTIYALSTPANQTSAIAIIRISGTHAKYIYNRLVDSSTVPPIRKAILRNIYSPSSCSVKPHDQKESKILLDTSLLLYFQAPYSFTGEDVLELHVHGGKAVVNSILKAIGSLHDRSSGKDIRFALPGDFSRRAFQNGKFDLTQLEGIKDLIDSETESQRRSALSSFNGDNKILFENWRETIIENMAQLTAIIDFADDNSQEIQNTDEIFHNVEKNIICLRDQIVTFMQKVEKSTILQNGIKLVLLGAPNVGKSSLVNSLTNDDISIVSDIPGTTRDSIDAMINVNGYKVIICDTAGIREKSSDKIEMLGIDRAKKKSVQSDLCLFIVDPTDLSKLLPEDILAHLSSKTFGNKRIIIVVNKSDLVSDDEMTKVLNKLQTRLGSKYPILSVSCKTKEGIESLISTLTSNFESLSQSSADASPVIVSKRVSEILKNDVLYGLEEFFKSKDFHNDIVLATENLRYASDGIAKITGQAIGIEEILDSVFSKFCIGK
SIO_010081: YMR023C
subclass of: SO_0000673
so part of: YMR023C
location: complement(319437..321017)
location: region:319437-321017:-1
so has part: feature:319437-321017:-1:exon

NP_013736.1
type: Protein
SIO_000068: ncbiprotein

S000004625
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:319437-321017:-1:exon

YNCM0018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0018C
so part of: sequence
location: complement(321147..321219)
location: region:321147-321219:-1
so has part: feature:321147-321219:-1:exon
subclass of: SO_0000663

855038
type: Gene
SIO_000068: ncbigene

position:321147:-1
position: 321147
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:321219:-1
position: 321219
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321147-321219:-1:exon

YNCM0018C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0018C
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCM0018C
subclass of: SO_0000673
so part of: YNCM0018C
location: complement(321147..321219)
location: region:321147-321219:-1
so has part: feature:321147-321219:-1:exon

S000006518
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:321147-321219:-1:exon

YMR024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL44
gene: MRPL3
locus tag: YMR024W
gene synonym: mL44
so part of: sequence
location: <321875..>323047
location: region:321875-323047:1
so has part: feature:321875-323047:1:exon
subclass of: SO_0000010

855039
type: Gene
SIO_000068: ncbigene

position:321875:1
position: 321875
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:323047:1
position: 323047
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321875-323047:1:exon

YMR024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL44
gene: MRPL3
locus tag: YMR024W
gene synonym: mL44
product: mitochondrial 54S ribosomal protein YmL3
transcript id: NM_001182520.1
SIO_010081: YMR024W
subclass of: SO_0000673
so part of: YMR024W
location: <321875..>323047
location: region:321875-323047:1
so has part: feature:321875-323047:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:321875-323047:1:exon

YMR024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL44
gene: MRPL3
locus tag: YMR024W
gene synonym: mL44
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]
note: Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type
codon start: 1
product: mitochondrial 54S ribosomal protein YmL3
translation: MGIVLKRAIAAGMKPFPNSTWHWSRTIRPFSQHLSSTCFLQQSSRFTSKRYLHLSTLTQQEKRFLPESELAKYKEYYQGLKSTVNEIPESVASKSPSLRTLHKRLQLPNELTYSTLSRCLTCPSAKLPDKINNPTKGAAFVNTVPTNKYLDNHGLNIMGKNLLSYHVTKSIIQKYPRLPTVVLNAAVNAYISEAVLAHIAKYWGIEVETTSVLSRYLKMEPFEFTLGRLKFFNNSLNSKDGIELITGKNFSETSALAMSVRSIIAAIWAVTEQKDSQAVYRFIDDHIMSRKLDITKMFQFEQPTRELAMLCRREGLEKPVSKLVAESGRLSKSPVFIVHVFSGEETLGEGYGSSLKEAKARAATDALMKWYCYEPLAQQEPVIDPGTVVV
SIO_010081: YMR024W
subclass of: SO_0000673
so part of: YMR024W
location: 321875..323047
location: region:321875-323047:1
so has part: feature:321875-323047:1:exon

NP_013737.1
type: Protein
SIO_000068: ncbiprotein

S000004626
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:321875-323047:1:exon

YMR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSI1
locus tag: YMR025W
so part of: sequence
location: <323300..>324187
location: region:323300-324187:1
so has part: feature:323300-324187:1:exon
subclass of: SO_0000010

855040
type: Gene
SIO_000068: ncbigene

position:323300:1
position: 323300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:324187:1
position: 324187
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323300-324187:1:exon

YMR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSI1
locus tag: YMR025W
product: Csi1p
transcript id: NM_001182521.1
SIO_010081: YMR025W
subclass of: SO_0000673
so part of: YMR025W
location: <323300..>324187
location: region:323300-324187:1
so has part: feature:323300-324187:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323300-324187:1:exon

YMR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSI1
locus tag: YMR025W
experiment: EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]
experiment: EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12186635|PMID:12446563]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:12446563]
note: Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
codon start: 1
product: Csi1p
translation: MDLLKFSSLAISEINFLHESSFDSIDHSWFLLIGCKLDQDDEIYIPINGNEAESQWYIEKVIRIPMQENDKINQERLERRINLTKVTQKDICILGILDLCQLEEDENITNKVTEKVLTQLTALALKYLIKYNVFRQHTSFQEAVNSLKGYKIENSVQIGAEIILDFLQDKVQIKDVNDRYQIPTPNNTVDPGFDEFQLIDMKDKEINIQKYNNNTIRKLLEKINRMIIFLKNYDATDKPFSSTQDVILRKISMLVTQLQRGGTSDMNYLLDNKINEIKLLEISCKQWEISNMLKK
SIO_010081: YMR025W
subclass of: SO_0000673
so part of: YMR025W
location: 323300..324187
location: region:323300-324187:1
so has part: feature:323300-324187:1:exon

NP_013738.1
type: Protein
SIO_000068: ncbiprotein

S000004627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323300-324187:1:exon

YMR026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS11
gene: PEX12
locus tag: YMR026C
gene synonym: PAS11
so part of: sequence
location: complement(<324236..>325435)
location: region:324236-325435:-1
so has part: feature:324236-325435:-1:exon
subclass of: SO_0000010

855041
type: Gene
SIO_000068: ncbigene

position:324236:-1
position: 324236
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:325435:-1
position: 325435
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:324236-325435:-1:exon

YMR026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS11
gene: PEX12
locus tag: YMR026C
gene synonym: PAS11
product: ubiquitin-protein ligase peroxin 12
transcript id: NM_001182522.1
SIO_010081: YMR026C
subclass of: SO_0000673
so part of: YMR026C
location: complement(<324236..>325435)
location: region:324236-325435:-1
so has part: feature:324236-325435:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:324236-325435:-1:exon

YMR026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS11
gene: PEX12
locus tag: YMR026C
gene synonym: PAS11
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:11370741]
experiment: EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:24034674]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:19687296|PMID:22471590]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]
experiment: EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:11370741|PMID:15536088|PMID:9090384]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12667447]
note: C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
codon start: 1
product: ubiquitin-protein ligase peroxin 12
translation: MSFYSNLPSAGQSSRGSSTSGRNGVGLEPLYPTIFEIMSSQEIDSLLPASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYNSTFIDRFYGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEILEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQYLFKIEYTTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRFLTFMGSQFFPTFIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEACPVCEKTVQNPCVLETGYVACYPCAISYLVNNEGHCPVTNKKLLGCTYNKHTNKWEVVTGIRKLLI
SIO_010081: YMR026C
subclass of: SO_0000673
so part of: YMR026C
location: complement(324236..325435)
location: region:324236-325435:-1
so has part: feature:324236-325435:-1:exon

NP_013739.1
type: Protein
SIO_000068: ncbiprotein

S000004628
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:324236-325435:-1:exon

YMR027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR027W
so part of: sequence
location: <325877..>327289
location: region:325877-327289:1
so has part: feature:325877-327289:1:exon
subclass of: SO_0000010

855042
type: Gene
SIO_000068: ncbigene

position:325877:1
position: 325877
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:327289:1
position: 327289
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325877-327289:1:exon

YMR027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR027W
product: putative methyltransferase
transcript id: NM_001182523.1
SIO_010081: YMR027W
subclass of: SO_0000673
so part of: YMR027W
location: <325877..>327289
location: region:325877-327289:1
so has part: feature:325877-327289:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325877-327289:1:exon

YMR027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR027W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:27322068]
note: A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
codon start: 1
product: putative methyltransferase
translation: MTIPGRFMTIDKGTFGEYTASTRWPIIIQNAIDDLSKHQETEKSNGTKFEQGEVIKKELKEFRQEIIDRVPLRPFTEEEIKIANVPLSFNEYLKKHPEVNWGAVEWLFSEVYLYRRVNVLFQRQCEWAKFDIFNRLKQSTFESSFYGVVELALRYENLLPQLREMKQNPGNEIDDILKVLFKEFIEISLWGNATDLSLLTNATLEDIKSIQGAKARAASESKIVVNDTEKAWEVLTKARADANSREIRVDFVLDNSGFELYADLMLAAFLLQSGLATKCIFHAKDIPYMVSDVMLKDFDILVHDLRDREFFPSGEPSTKESRALDLFAGEMEKFVSSGKIEFREDSFWTTELDYWNLDANETKYHGSILHKDLQKSNLVIFKGDLNYRKLTGDRKWPRTTKWETAIGPLATNGITSLSLRTCKADVQVALPEGLDAKLSQEWEKENPGRGSWWCCSGKWAVICFCSGIHK
SIO_010081: YMR027W
subclass of: SO_0000673
so part of: YMR027W
location: 325877..327289
location: region:325877-327289:1
so has part: feature:325877-327289:1:exon

NP_013740.1
type: Protein
SIO_000068: ncbiprotein

S000004629
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325877-327289:1:exon

YMR028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TAP42
locus tag: YMR028W
so part of: sequence
location: <327482..>328582
location: region:327482-328582:1
so has part: feature:327482-328582:1:exon
subclass of: SO_0000010

855043
type: Gene
SIO_000068: ncbigene

position:327482:1
position: 327482
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:328582:1
position: 328582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:327482-328582:1:exon

YMR028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TAP42
locus tag: YMR028W
product: Tap42p
transcript id: NM_001182524.1
SIO_010081: YMR028W
subclass of: SO_0000673
so part of: YMR028W
location: <327482..>328582
location: region:327482-328582:1
so has part: feature:327482-328582:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:327482-328582:1:exon

YMR028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TAP42
locus tag: YMR028W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16874307]
experiment: EXISTENCE:genetic interaction:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]
experiment: EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:10329624|PMID:14551259]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]
experiment: EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:10604478|PMID:12820961]
note: Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
codon start: 1
product: Tap42p
translation: MASVTEQFNDIISLYSTKLEHTSLRQDSPEYQGLLLSTIKKLLNLKTAIFDRLALFSTNETIDDVSTASIKFLAVDYYLGLLISRRQSNDSDVAQRQSMKLIYLKKSVESFINFLTLLQDYKLLDPLVGEKLGNFKDRYNPQLSELYAQPKNNKDLSGAQLKRKEKIELFQRNKEISTKLHCLELELKNNDEDHDHDELLRELYLMRLHHFSLDTINNIEQNLFECEMLSNFLKNSVHEVKSSGTQIRKESNDDDSTGFTDKLENINKPLIDKKGQVLRNFTLVDKRQQLQQKVRGYGQYGPTMSVEEFLDKEFEEGRVLQGGEEPEQAPDEENMDWQDRETYKAREWDEFKESHAKGSGNTMNRG
SIO_010081: YMR028W
subclass of: SO_0000673
so part of: YMR028W
location: 327482..328582
location: region:327482-328582:1
so has part: feature:327482-328582:1:exon

NP_013741.1
type: Protein
SIO_000068: ncbiprotein

S000004630
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:327482-328582:1:exon

YMR029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAR8
locus tag: YMR029C
so part of: sequence
location: complement(<328660..>330231)
location: region:328660-330231:-1
so has part: feature:328660-330231:-1:exon
subclass of: SO_0000010

855044
type: Gene
SIO_000068: ncbigene

position:328660:-1
position: 328660
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330231:-1
position: 330231
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328660-330231:-1:exon

YMR029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAR8
locus tag: YMR029C
product: Far8p
transcript id: NM_001182525.1
SIO_010081: YMR029C
subclass of: SO_0000673
so part of: YMR029C
location: complement(<328660..>330231)
location: region:328660-330231:-1
so has part: feature:328660-330231:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:328660-330231:-1:exon

YMR029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAR8
locus tag: YMR029C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]
note: Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
codon start: 1
product: Far8p
translation: MAINQAHVHPHYTLPGVMHYLQTEFTKNERDRITWELERSEMKARIAELEGENRDLKHQLNQIQSKAVSPEGEKEEKHVPDSLLQSKLAVQENVKEIIYLLKGPNTVNQLESLNSREAGSELHDLEKLNVNTPKEEGSAKTNGMDILNNALLDTKPNPKQGPSESPSPTKVKSLFSTANKRENNETISKIHSELSKVDIISSYGDCMALYDADTKSLEIHQVDANLNSKLLKKISLGQDSDIMKFFWVSTSKLLVIEKSFHLKLFSISSASLISDVDLLQDSEQPFSSSDIINIDFKNKWLLIASKNKSQIRIWELDNIEAPEDVPINIKETYEITHDNDDDDSNDSTNILDCILGITEKSLILLSSNPYQLTIYDFEGKLLQKIDLKIDTILSGKPEEEGYHLFLDRKTSKLLIQLSNERLLVYSFDKKKVVLKEQLTPSSTLPIQLDLNDSIITVSYSNGDFEFRNLENLKPSIDEFVVADINFSERKEPVVFSSNLIVDSTPVLITVNKNNEVLLHKIKI
SIO_010081: YMR029C
subclass of: SO_0000673
so part of: YMR029C
location: complement(328660..330231)
location: region:328660-330231:-1
so has part: feature:328660-330231:-1:exon

NP_013742.1
type: Protein
SIO_000068: ncbiprotein

S000004631
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328660-330231:-1:exon

YMR030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSF1
locus tag: YMR030W
so part of: sequence
location: <330793..>331923
location: region:330793-331923:1
so has part: feature:330793-331923:1:exon
subclass of: SO_0000010

855045
type: Gene
SIO_000068: ncbigene

position:330793:1
position: 330793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:331923:1
position: 331923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330793-331923:1:exon

YMR030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSF1
locus tag: YMR030W
product: Rsf1p
transcript id: NM_001182526.1
SIO_010081: YMR030W
subclass of: SO_0000673
so part of: YMR030W
location: <330793..>331923
location: region:330793-331923:1
so has part: feature:330793-331923:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330793-331923:1:exon

YMR030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSF1
locus tag: YMR030W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12734673]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12734673]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12734673]
experiment: EXISTENCE:mutant phenotype:GO:0006390 mitochondrial transcription [PMID:12734673]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:12734673]
note: Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
codon start: 1
product: Rsf1p
translation: MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMETPRILNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNHLSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQHTN
SIO_010081: YMR030W
subclass of: SO_0000673
so part of: YMR030W
location: 330793..331923
location: region:330793-331923:1
so has part: feature:330793-331923:1:exon

NP_013743.1
type: Protein
SIO_000068: ncbiprotein

S000004632
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330793-331923:1:exon

YMR031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EIS1
locus tag: YMR031C
so part of: sequence
location: complement(<332212..>334743)
location: region:332212-334743:-1
so has part: feature:332212-334743:-1:exon
subclass of: SO_0000010

855047
type: Gene
SIO_000068: ncbigene

position:332212:-1
position: 332212
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334743:-1
position: 334743
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:332212-334743:-1:exon

YMR031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EIS1
locus tag: YMR031C
product: Eis1p
transcript id: NM_001182527.1
SIO_010081: YMR031C
subclass of: SO_0000673
so part of: YMR031C
location: complement(<332212..>334743)
location: region:332212-334743:-1
so has part: feature:332212-334743:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:332212-334743:-1:exon

YMR031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EIS1
locus tag: YMR031C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19064668|PMID:19269952|PMID:20526336]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0032126 eisosome [PMID:20526336]
experiment: EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:20526336]
note: Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication
codon start: 1
product: Eis1p
translation: MSLISAVEDRDIHNIGKTSGGGSRTSSITSSKKSLKHGSKSLRKPKVYQTTGEPLSREALYKAKLKYGVYQSPAQSYSIGVSDAHAASDKAANLAHDNQTTVEAYKRMFIDPNATKAASKMGPKVVRNNSITSATSKTSKESQTKRKSKESPGAAASKAYSMTMETTSLSSQTNSRSYSITSASSVLSGASGSFNSTVNPKPKTLNLEKVLVGAEKKAESRIKERWEPEKTNFQYGVKTDEHGNLNQFSFSNEMMNNIMAKVDAPKAQDLQKVKKVSAEKEAKSMKFALGAANAVKDMHPGEDIDKSIALKAQKRETYLSQLTSQQVLTLARANVDRQLDIIEKSDMHRKLFTNMEYNKAAVAVAQSNHQKKTEFHNKINMGGGLFLSPEDITKIASGLISPVLGEVSERAEAQRAMDEEIAERTEAYNKSSNEWETMERSIISNDAKVLTTTANRHQTEKKTSQEKIKASFDALVARMDTKVAERETLLEDTKSKEIEFKKQMQQELKDEKARLDQDLEEWGKKCEQDITEARKEQEELLKPYHDDLANAEAEHKTLVEERDEINAEISRLQDAIVDHKRKISGYGNDLDAQKNRNIREDDKLLELGQTKESLESHLNDDVIILANKAKEQAELSTKEARLKQLEVDSLINERKSELNATEIELKKEKLNLLEAMKDVASARGDDKIDEEKVKKLIGMTSEEYLTQNKSVEKNVEDLPTQLEKIEEGDELKKEEIVGAETKNSGGDGVPVSTAAKEATETSSAVQTKEPEEKISIGNKSSGKEDANDCKSAEHSKEISVSQKAGNNKSLGVSPDSLEHTFSGFSQGSSIEDDQDAISNQEKK
SIO_010081: YMR031C
subclass of: SO_0000673
so part of: YMR031C
location: complement(332212..334743)
location: region:332212-334743:-1
so has part: feature:332212-334743:-1:exon

NP_013744.1
type: Protein
SIO_000068: ncbiprotein

S000004633
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:332212-334743:-1:exon

YMR032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYK2
gene: HOF1
locus tag: YMR032W
gene synonym: CYK2
so part of: sequence
location: <335298..>337307
location: region:335298-337307:1
so has part: feature:335298-337307:1:exon
subclass of: SO_0000010

855048
type: Gene
SIO_000068: ncbigene

position:335298:1
position: 335298
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337307:1
position: 337307
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:335298-337307:1:exon

YMR032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYK2
gene: HOF1
locus tag: YMR032W
gene synonym: CYK2
product: formin-binding protein HOF1
transcript id: NM_001182529.1
SIO_010081: YMR032W
subclass of: SO_0000673
so part of: YMR032W
location: <335298..>337307
location: region:335298-337307:1
so has part: feature:335298-337307:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:335298-337307:1:exon

YMR032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYK2
gene: HOF1
locus tag: YMR032W
gene synonym: CYK2
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15775961|PMID:9864366|PMID:21498574|PMID:23468521|PM ID:24451263]
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:9864366|PMID:21498574|PMID:23468521|PMID:24451263]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:25620000]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27385335|PMID:23468521]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23468521]
experiment: EXISTENCE:direct assay:GO:0008092 cytoskeletal protein binding [PMID:18344988|PMID:9774458]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23468521]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:23468521]
experiment: EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:32579428]
experiment: EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:32579428]
experiment: EXISTENCE:direct assay:GO:0051126 negative regulation of actin nucleation [PMID:30076201]
experiment: EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]
experiment: EXISTENCE:genetic interaction:GO:0000281 mitotic cytokinesis [PMID:22623719]
experiment: EXISTENCE:genetic interaction:GO:0072741 protein localization to cell division site [PMID:23469085]
experiment: EXISTENCE:genetic interaction:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:24719456]
experiment: EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]
experiment: EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:9774458]
experiment: EXISTENCE:mutant phenotype:GO:0031671 primary cell septum biogenesis [PMID:29321253|PMID:21498574]
experiment: EXISTENCE:mutant phenotype:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:24719456]
experiment: EXISTENCE:mutant phenotype:GO:1902406 mitotic actomyosin contractile ring maintenance [PMID:9864366]
experiment: EXISTENCE:mutant phenotype:GO:1903471 regulation of mitotic actomyosin contractile ring contraction [PMID:24895401|PMID:21498574|PMID:23468521]
experiment: EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]
experiment: EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:23468521]
experiment: EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]
experiment: EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24413167|PMID:24895401]
note: F-BAR protein that regulates actin cytoskeleton organization; binds and bundles actin filaments, linking them to septins; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; regulates actomyosin ring dynamics and septin localization; N-term. half controls cell size and actin cable levels, while the C-term. half controls actin cable organization, inhibiting Bnr1p-mediated actin nucleation; forms axial striations/pillars at the bud neck; phosphorylated by Dbf2p
codon start: 1
product: formin-binding protein HOF1
translation: MSYSYEACFWDPNDNGVNILLGHISQGIRSCDSMILFFKQRSELEKDYARRLGAITGKLDKDIGTNMDYGKLNETFNVVLSVEKARAQSHSKQSEILFRQIYTDTKAFAANLQARYTTLSGKIERLRMDKFNKKKGCEVLQKKLQDAQIRFRDLQLNENNMIGAKRVEHNKRELLKWESNSQEYKVQLDVLKQEYKASQKFWIHEWAQLSCELQEMENARISFLQSKLQQFATSSMETYILEQTKMDMLTNHLNSFTAADEISTFSKENGTGRLKHKTSKGDMNSSANWAQMSSISTTSKKTESYMDNIRKLSSQLKETENKRKLASIDKYEKPLPSPEVTMATQFRNSTPVIRNETKVVANPTLSLRSSPVQLQSNVDDSVLRQKPDKPRPIVGEEQLKPDEDSKNPDEKGLMVHKRNQSLSSPSESSSSNPTDFSHIKKRQSMESMTTSVSSMANSIDDSQRFAKSWNSSNRKRKSMSHLQVPSSASSRSDDGGRTPNSAHNLNEDDYNTRRDTSTSTILFKPPVAVRGTSRGHTHRQSMIMQDSSNPIEDALYEMERIQSSSKPGTKTGNIMDERGVVRDRGITVTLPIVTSEGFPVIEYAKAMYPLIGNEAPGLANFHKGDYLLITEIVNKDWYKGEVYDNDRIDRNHRIGLIPYNFIQLLHQGL
SIO_010081: YMR032W
subclass of: SO_0000673
so part of: YMR032W
location: 335298..337307
location: region:335298-337307:1
so has part: feature:335298-337307:1:exon

NP_013746.1
type: Protein
SIO_000068: ncbiprotein

S000004635
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:335298-337307:1:exon

YMR030W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR030W-A
so part of: sequence
location: <337313..>337603
location: region:337313-337603:1
so has part: feature:337313-337603:1:exon
subclass of: SO_0000010

1466499
type: Gene
SIO_000068: ncbigene

position:337313:1
position: 337313
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337603:1
position: 337603
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337313-337603:1:exon

YMR030W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR030W-A
product: uncharacterized protein
transcript id: NM_001184572.1
SIO_010081: YMR030W-A
subclass of: SO_0000673
so part of: YMR030W-A
location: <337313..>337603
location: region:337313-337603:1
so has part: feature:337313-337603:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337313-337603:1:exon

YMR030W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR030W-A
note: hypothetical protein; mCherry fusion protein localizes to the cytosol
codon start: 1
product: uncharacterized protein
translation: MYINFTSFLIKEKKYNVRFLLSRNRKIYAAVGEGHLSGFVTKNHKISRLSFIFSKKKKVFFTIFDTIITIIVRSGIPFPLLCSFGRNKIYILFNVL
SIO_010081: YMR030W-A
subclass of: SO_0000673
so part of: YMR030W-A
location: 337313..337603
location: region:337313-337603:1
so has part: feature:337313-337603:1:exon

NP_878141.1
type: Protein
SIO_000068: ncbiprotein

S000028574
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337313-337603:1:exon

YMR033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RSC12
alternative label: SWP59
gene: ARP9
locus tag: YMR033W
gene synonym: RSC12; SWP59
so part of: sequence
location: <337788..>339277
location: region:337788-339277:1
so has part: feature:337788-339277:1:exon
subclass of: SO_0000010

855049
type: Gene
SIO_000068: ncbigene

position:337788:1
position: 337788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339277:1
position: 339277
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337788-339277:1:exon

YMR033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RSC12
alternative label: SWP59
gene: ARP9
locus tag: YMR033W
gene synonym: RSC12; SWP59
product: Arp9p
transcript id: NM_001182530.1
SIO_010081: YMR033W
subclass of: SO_0000673
so part of: YMR033W
location: join(<337788..337817,337904..>339277)
location: region:337788-339277:1
so has part: feature:337788-337817:1:exon
so has part: feature:337904-339277:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337788-337817:1:exon

position:337817:1
position: 337817
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:337904-339277:1:exon

position:337904:1
position: 337904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RSC12
alternative label: SWP59
gene: ARP9
locus tag: YMR033W
gene synonym: RSC12; SWP59
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:8127913|PMID:9726966]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12183366]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12183366]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9726966]
note: Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
codon start: 1
product: Arp9p
translation: MAPFRQDSILIIYPRSQTTLVQFGLNEETFTVPELEIPTQIYRTTRQDGSYTYHSTNKDNKAELIKPIQNGEIIDISAFTQFLRLIFVSILSDRANKNQDAFEAELSNIPLLLITHHSWSQSDLEIITQYVFESLEINNLIQLPASLAATYSMISLQNCCIIDVGTHHTDIIPIVDYAQLDHLVSSIPMGGQSINDSLKKLLPQWDDDQIESLKKSPIFEVLSDDAKKLSSFDFGNENEDEDEGTLNVAEIITSGRDTREVLEERERGQKVKNVKNSDLEFNTFWDEKGNEIKVGKQRFQGCNNLIKNISNRVGLTLDNIDDINKAKAVWENIIIVGGTTSISGFKEALLGQLLKDHLIIEPEEEKSKREEEAKSVLPAATKKKSKFMTNSTAFVPTIEYVQCPTVIKLAKYPDYFPEWKKSGYSEIIFLGAQIVSKQIFTHPKDTFYITREKYNMKGPAALWDVQF
SIO_010081: YMR033W
subclass of: SO_0000673
so part of: YMR033W
location: join(337788..337817,337904..339277)
location: region:337788-339277:1
so has part: feature:337788-337817:1:exon
so has part: feature:337904-339277:1:exon

NP_013747.1
type: Protein
SIO_000068: ncbiprotein

S000004636
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337788-337817:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:337904-339277:1:exon

YMR034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCH1
locus tag: YMR034C
so part of: sequence
location: complement(<339418..>340722)
location: region:339418-340722:-1
so has part: feature:339418-340722:-1:exon
subclass of: SO_0000010

855050
type: Gene
SIO_000068: ncbigene

position:339418:-1
position: 339418
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340722:-1
position: 340722
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339418-340722:-1:exon

YMR034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCH1
locus tag: YMR034C
product: Rch1p
transcript id: NM_001182531.1
SIO_010081: YMR034C
subclass of: SO_0000673
so part of: YMR034C
location: complement(<339418..>340722)
location: region:339418-340722:-1
so has part: feature:339418-340722:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339418-340722:-1:exon

YMR034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCH1
locus tag: YMR034C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26832117]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26832117]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0051481 negative regulation of cytosolic calcium ion concentration [PMID:26832117]
note: Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1
codon start: 1
product: Rch1p
translation: MKTQYSLIRKIWAHSVTEFLKSQWFFICLAILIVIARFAPNFARDGGLIKGQYSIGYGCVAWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVYGFCCAVKAANDPKIDDWVLIGLILTATCPTTVASNVIMTTNAGGNSLLCVCEVFIGNLLGAFITPALVQMFTNRAPFAYGNPATGNGIGALYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYLGFLKKYHIKIGSYMLLLIMFSSFSTAFYQDAFTSVSHVCIIFLCFFNLGIYIFFTGLSYLCARPWFILKLFPHEPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDKKEHLGKLLVPLVLYQVEQVMTANFFVSLFKRWIQKDAQADGSESSCANENEEVDLEKIISIGTGENQSVLSNNVPYTQPR
SIO_010081: YMR034C
subclass of: SO_0000673
so part of: YMR034C
location: complement(339418..340722)
location: region:339418-340722:-1
so has part: feature:339418-340722:-1:exon

NP_013748.1
type: Protein
SIO_000068: ncbiprotein

S000004637
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339418-340722:-1:exon

YMR035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMP2
locus tag: YMR035W
so part of: sequence
location: <341142..>341675
location: region:341142-341675:1
so has part: feature:341142-341675:1:exon
subclass of: SO_0000010

855051
type: Gene
SIO_000068: ncbigene

position:341142:1
position: 341142
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:341675:1
position: 341675
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341142-341675:1:exon

YMR035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMP2
locus tag: YMR035W
product: endopeptidase catalytic subunit
transcript id: NM_001182532.1
SIO_010081: YMR035W
subclass of: SO_0000673
so part of: YMR035W
location: <341142..>341675
location: region:341142-341675:1
so has part: feature:341142-341675:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341142-341675:1:exon

YMR035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMP2
locus tag: YMR035W
experiment: EXISTENCE:direct assay:GO:0004175 endopeptidase activity [PMID:8132591]
experiment: EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:8266095]
experiment: EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:8266095]
experiment: EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:8132591|PMID:8266095]
note: Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p
codon start: 1
product: endopeptidase catalytic subunit
translation: MFRAGSSKRFLRNTLIAISWVPVLLTINNNVVHIAQVKGTSMQPTLNPQTETLATDWVLLWKFGVKNPSNLSRDDIILFKAPTNPRKVYCKRVKGLPFDTIDTKFPYPKPQVNLPRGHIWVEGDNYFHSIDSNTFGPISSGLVIGKAITIVWPPSRWGTDLKLSTGRDCISKRAILE
SIO_010081: YMR035W
subclass of: SO_0000673
so part of: YMR035W
location: 341142..341675
location: region:341142-341675:1
so has part: feature:341142-341675:1:exon

NP_013749.1
type: Protein
SIO_000068: ncbiprotein

S000004638
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341142-341675:1:exon

YMR036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIH1
locus tag: YMR036C
so part of: sequence
location: complement(<341856..>343520)
location: region:341856-343520:-1
so has part: feature:341856-343520:-1:exon
subclass of: SO_0000010

855052
type: Gene
SIO_000068: ncbigene

position:341856:-1
position: 341856
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343520:-1
position: 343520
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341856-343520:-1:exon

YMR036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIH1
locus tag: YMR036C
product: putative tyrosine protein phosphatase MIH1
transcript id: NM_001182533.1
SIO_010081: YMR036C
subclass of: SO_0000673
so part of: YMR036C
location: complement(<341856..>343520)
location: region:341856-343520:-1
so has part: feature:341856-343520:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341856-343520:-1:exon

YMR036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIH1
locus tag: YMR036C
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:2649252]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:2649252]
experiment: EXISTENCE:mutant phenotype:GO:0051231 spindle elongation [PMID:30072442]
note: Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25
codon start: 1
product: putative tyrosine protein phosphatase MIH1
translation: MNNIFHGTEDECANEDVLSFQKISLKSPFGKKKNIFRNVQTFFKSKSKHSNVDDDLINKENLAFDKSPLLTNHRSKEIDGPSPNIKQLGHRDELDENENENDDIVLSMHFASQTLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQRSSSFSRSRSLSRKPSMNSSSNSSRRVQRQDGKIPRSSRKSSQKFSNITQNTLNFTSASSSPLAPNSVGVKCFESCLAKTQIPYYYDDRNSNDFFPRISPETLKNILQNNMCESFYNSCRIIDCRFEYEYTGGHIINSVNIHSRDELEYEFIHKVLHSDTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHYPKLFYPDILILDGGYKAVFDNFPELCYPRQYVGMNSQENLLNCEQEMDKFRRESKRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK
SIO_010081: YMR036C
subclass of: SO_0000673
so part of: YMR036C
location: complement(341856..343520)
location: region:341856-343520:-1
so has part: feature:341856-343520:-1:exon

NP_013750.1
type: Protein
SIO_000068: ncbiprotein

S000004639
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341856-343520:-1:exon

YMR037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSN2
locus tag: YMR037C
so part of: sequence
location: complement(<344403..>346517)
location: region:344403-346517:-1
so has part: feature:344403-346517:-1:exon
subclass of: SO_0000010

855053
type: Gene
SIO_000068: ncbigene

position:344403:-1
position: 344403
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346517:-1
position: 346517
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:344403-346517:-1:exon

YMR037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSN2
locus tag: YMR037C
product: stress-responsive transcriptional activator MSN2
transcript id: NM_001182534.1
SIO_010081: YMR037C
subclass of: SO_0000673
so part of: YMR037C
location: complement(<344403..>346517)
location: region:344403-346517:-1
so has part: feature:344403-346517:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:344403-346517:-1:exon

YMR037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSN2
locus tag: YMR037C
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23435728|PMID:8650168]
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8321194|PMID:8641288|PMID:8650168]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12093809|PMID:12732613|PMID:9472026|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12732613|PMID:9472026|PMID:12093809]
experiment: EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:18070923]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17914901]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:27637775|PMID:19702872|PMID:17914901|P MID:8641288|PMID:11102521|PMID:11179418|PMID:15053871|PMID :15483057|PMID:15922872|PMID:16710843|PMID:17055490|PMID:1 9073887|PMID:21749328|PMID:26947009|PMID:10652100|PMID:171 50183]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8650168]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11102521|PMID:15922872|PMID:16980434|PMID:8650168]
note: Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; light sensing pathway component that accumulates in the nucleus in response to blue light; relative distribution to nucleus increases upon DNA replication stress
codon start: 1
product: stress-responsive transcriptional activator MSN2
translation: MTVDHDFNSEDILFPIESMSSIQYVENNNPNNINNDVIPYSLDIKNTVLDSADLNDIQNQETSLNLGLPPLSFDSPLPVTETIPSTTDNSLHLKADSNKNRDARTIENDSEIKSTNNASGSGANQYTTLTSPYPMNDILYNMNNPLQSPSPSSVPQNPTINPPINTASNETNLSPQTSNGNETLISPRAQQHTSIKDNRLSLPNGANSNLFIDTNPNNLNEKLRNQLNSDTNSYSNSISNSNSNSTGNLNSSYFNSLNIDSMLDDYVSSDLLLNDDDDDTNLSRRRFSDVITNQFPSMTNSRNSISHSLDLWNHPKINPSNRNTNLNITTNSTSSSNASPNTTTMNANADSNIAGNPKNNDATIDNELTQILNEYNMNFNDNLGTSTSGKNKSACPSSFDANAMTKINPSQQLQQQLNRVQHKQLTSSHNNSSTNMKSFNSDLYSRRQRASLPIIDDSLSYDLVNKQDEDPKNDMLPNSNLSSSQQFIKPSMILSDNASVIAKVATTGLSNDMPFLTEEGEQNANSTPNFDLSITQMNMAPLSPASSSSTSLATNHFYHHFPQQGHHTMNSKIGSSLRRRKSAVPLMGTVPLTNQQNNISSSSVNSTGNGAGVTKERRPSYRRKSMTPSRRSSVVIESTKELEEKPFHCHICPKSFKRSEHLKRHVRSVHSNERPFACHICDKKFSRSDNLSQHIKTHKKHGDI
SIO_010081: YMR037C
subclass of: SO_0000673
so part of: YMR037C
location: complement(344403..346517)
location: region:344403-346517:-1
so has part: feature:344403-346517:-1:exon

NP_013751.1
type: Protein
SIO_000068: ncbiprotein

S000004640
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:344403-346517:-1:exon

YMR038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LYS7
gene: CCS1
locus tag: YMR038C
gene synonym: LYS7
so part of: sequence
location: complement(<347511..>348260)
location: region:347511-348260:-1
so has part: feature:347511-348260:-1:exon
subclass of: SO_0000010

855054
type: Gene
SIO_000068: ncbigene

position:347511:-1
position: 347511
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:348260:-1
position: 348260
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347511-348260:-1:exon

YMR038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LYS7
gene: CCS1
locus tag: YMR038C
gene synonym: LYS7
product: copper chaperone CCS1
transcript id: NM_001182535.1
SIO_010081: YMR038C
subclass of: SO_0000673
so part of: YMR038C
location: complement(<347511..>348260)
location: region:347511-348260:-1
so has part: feature:347511-348260:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:347511-348260:-1:exon

YMR038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LYS7
gene: CCS1
locus tag: YMR038C
gene synonym: LYS7
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18977757]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11500508]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9295278]
experiment: EXISTENCE:genetic interaction:GO:0016532 superoxide dismutase copper chaperone activity [PMID:9295278]
experiment: EXISTENCE:mutant phenotype:GO:0015680 protein maturation by copper ion transfer [PMID:9295278]
experiment: EXISTENCE:mutant phenotype:GO:0016532 superoxide dismutase copper chaperone activity [PMID:9295278]
note: Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant
codon start: 1
product: copper chaperone CCS1
translation: MTTNDTYEATYAIPMHCENCVNDIKACLKNVPGINSLNFDIEQQIMSVESSVAPSTIINTLRNCGKDAIIRGAGKPNSSAVAILETFQKYTIDQKKDTAVRGLARIVQVGENKTLFDITVNGVPEAGNYHASIHEKGDVSKGVESTGKVWHKFDEPIECFNESDLGKNLYSGKTFLSAPLPTWQLIGRSFVISKSLNHPENEPSSVKDYSFLGVIARSAGVWENNKQVCACTGKTVWEERKDALANNIK
SIO_010081: YMR038C
subclass of: SO_0000673
so part of: YMR038C
location: complement(347511..348260)
location: region:347511-348260:-1
so has part: feature:347511-348260:-1:exon

NP_013752.1
type: Protein
SIO_000068: ncbiprotein

S000004641
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:347511-348260:-1:exon

YMR039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TSP1
gene: SUB1
locus tag: YMR039C
gene synonym: TSP1
so part of: sequence
location: complement(<348644..>349522)
location: region:348644-349522:-1
so has part: feature:348644-349522:-1:exon
subclass of: SO_0000010

855055
type: Gene
SIO_000068: ncbigene

position:348644:-1
position: 348644
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349522:-1
position: 349522
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:348644-349522:-1:exon

YMR039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TSP1
gene: SUB1
locus tag: YMR039C
gene synonym: TSP1
product: chromatin-binding transcription coactivator SUB1
transcript id: NM_001182536.1
SIO_010081: YMR039C
subclass of: SO_0000673
so part of: YMR039C
location: complement(<348644..>349522)
location: region:348644-349522:-1
so has part: feature:348644-349522:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:348644-349522:-1:exon

YMR039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TSP1
gene: SUB1
locus tag: YMR039C
gene synonym: TSP1
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:26147804]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26147804|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]
experiment: EXISTENCE:direct assay:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19204085|PMID:19706510]
experiment: EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:25813861]
experiment: EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:19706510]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]
experiment: EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:11389848]
experiment: EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:19204085]
experiment: EXISTENCE:genetic interaction:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19204085]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:23554872]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:15692559]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26837954]
experiment: EXISTENCE:mutant phenotype:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19204085|PMID:19706510]
experiment: EXISTENCE:mutant phenotype:GO:0075297 negative regulation of ascospore formation [PMID:26147804]
note: Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)
codon start: 1
product: chromatin-binding transcription coactivator SUB1
translation: MSYYNRYRNKRRSDNGGGNLSNSNNNNGGMPSGLSASDAIFDLGKNKRVTVRQFRNINLIDIREYYLDSSTGEMKPGKKGISLTEDLYDELLKHRLNIDEALRRLGSKRPKTKMVRLLSDDEYEDDNNNDSTNNDKDKNGKDKNSPKKRREDKSKASNESHDLEPRSKKKKPAPPTLLPHEENIQNAEREANATLIIPGQAGRKQQEERKQKEKEEAEEAKAKAVAEQEKEAKAKEKIAEPEPEPVPTLQAKKEDIVSNINESKDANSSDEEFAQSLEAEMNKAEDDISEEE
SIO_010081: YMR039C
subclass of: SO_0000673
so part of: YMR039C
location: complement(348644..349522)
location: region:348644-349522:-1
so has part: feature:348644-349522:-1:exon

NP_013753.1
type: Protein
SIO_000068: ncbiprotein

S000004642
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:348644-349522:-1:exon

YMR040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YET2
locus tag: YMR040W
so part of: sequence
location: <350381..>350863
location: region:350381-350863:1
so has part: feature:350381-350863:1:exon
subclass of: SO_0000010

855056
type: Gene
SIO_000068: ncbigene

position:350381:1
position: 350381
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:350863:1
position: 350863
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:350381-350863:1:exon

YMR040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YET2
locus tag: YMR040W
product: Yet2p
transcript id: NM_001182537.1
SIO_010081: YMR040W
subclass of: SO_0000673
so part of: YMR040W
location: <350381..>350863
location: region:350381-350863:1
so has part: feature:350381-350863:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:350381-350863:1:exon

YMR040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YET2
locus tag: YMR040W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication
codon start: 1
product: Yet2p
translation: MGVYLAVLFSLLVIEMAILFILVLPLPQRMRRWLYIRYSIISTNKKFRTYMVGIMIFVGLLFIDSWKRSQIRVSTYRNQKNPYIINSVTPVDALASRAYNQRNVYISGFIIYFYICILTVMSILRRIVEWNDKMKAGDDILKEKLRRKQKYLEELQKKKF
SIO_010081: YMR040W
subclass of: SO_0000673
so part of: YMR040W
location: 350381..350863
location: region:350381-350863:1
so has part: feature:350381-350863:1:exon

NP_013754.1
type: Protein
SIO_000068: ncbiprotein

S000004643
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:350381-350863:1:exon

YMR041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARA2
locus tag: YMR041C
so part of: sequence
location: complement(<350966..>351973)
location: region:350966-351973:-1
so has part: feature:350966-351973:-1:exon
subclass of: SO_0000010

855057
type: Gene
SIO_000068: ncbigene

position:350966:-1
position: 350966
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351973:-1
position: 351973
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:350966-351973:-1:exon

YMR041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARA2
locus tag: YMR041C
product: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2
transcript id: NM_001182538.1
SIO_010081: YMR041C
subclass of: SO_0000673
so part of: YMR041C
location: complement(<350966..>351973)
location: region:350966-351973:-1
so has part: feature:350966-351973:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:350966-351973:-1:exon

YMR041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARA2
locus tag: YMR041C
EC number: 1.1.1.116
experiment: EXISTENCE:direct assay:GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity [PMID:17097644]
experiment: EXISTENCE:mutant phenotype:GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity [PMID:17097644]
experiment: EXISTENCE:mutant phenotype:GO:0070485 dehydro-D-arabinono-1,4-lactone biosynthetic process [PMID:17097644]
note: NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
codon start: 1
product: D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2
translation: MVNEKVNPFDLASVSPLVLGGAILNQQYTDEPESIPLEDIIKYAFSHGINAIDTSPYYGPSEVLYGRALSNLRNEFPRDTYFICTKVGRIGAEEFNYSRDFVRFSVHRSCERLHTTYLDLVYLHDVEFVKFPDILEALKELRTLKNKGVIKNFGISGYPIDFITWLAEYCSTEESDIGSLDAVLSYCNLNLQNNKLLNFRERLLRNAKLKMVCNASILSMSLLRSQETRQFHPCSHELRECASQAAKYCQEQNVDLADLATRYAISEWVGKGPVVLGVSSMEELKLALDNYEIVKSNGNRLSSKDGQLVEYIQKNIFKEHFNEEWSSGIPHPEMI
SIO_010081: YMR041C
subclass of: SO_0000673
so part of: YMR041C
location: complement(350966..351973)
location: region:350966-351973:-1
so has part: feature:350966-351973:-1:exon

NP_013755.1
type: Protein
SIO_000068: ncbiprotein

S000004644
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:350966-351973:-1:exon

YNCM0019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0019W
so part of: sequence
location: 352280..352370
location: region:352280-352370:1
so has part: feature:352280-352370:1:exon
subclass of: SO_0000663

855058
type: Gene
SIO_000068: ncbigene

position:352280:1
position: 352280
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:352370:1
position: 352370
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352280-352370:1:exon

YNCM0019W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0019W
product: tRNA-Phe
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:10024171]
note: Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0019W
subclass of: SO_0000673
so part of: YNCM0019W
location: join(352280..352316,352335..352370)
location: region:352280-352370:1
so has part: feature:352280-352316:1:exon
so has part: feature:352335-352370:1:exon

S000006568
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352280-352316:1:exon

position:352316:1
position: 352316
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:352335-352370:1:exon

position:352335:1
position: 352335
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARGR1
gene: ARG80
locus tag: YMR042W
gene synonym: ARGR1
so part of: sequence
location: <352603..>353136
location: region:352603-353136:1
so has part: feature:352603-353136:1:exon
subclass of: SO_0000010

855059
type: Gene
SIO_000068: ncbigene

position:352603:1
position: 352603
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:353136:1
position: 353136
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352603-353136:1:exon

YMR042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARGR1
gene: ARG80
locus tag: YMR042W
gene synonym: ARGR1
product: Arg80p
transcript id: NM_001182539.1
SIO_010081: YMR042W
subclass of: SO_0000673
so part of: YMR042W
location: <352603..>353136
location: region:352603-353136:1
so has part: feature:352603-353136:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:352603-353136:1:exon

YMR042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARGR1
gene: ARG80
locus tag: YMR042W
gene synonym: ARGR1
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:12138185]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3311884|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:12138185]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8212891]
experiment: EXISTENCE:mutant phenotype:GO:1900079 regulation of arginine biosynthetic process [PMID:5434281]
experiment: EXISTENCE:mutant phenotype:GO:1900081 regulation of arginine catabolic process [PMID:12138185]
note: Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p
codon start: 1
product: Arg80p
translation: MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSPEQDQEGDFDEEDDDDKFSVSTSTPTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANILLLILANSGLVYTFTTPKLEPVVREDEGKSLIRACINASDTPDATDTSPAQEQSPAN
SIO_010081: YMR042W
subclass of: SO_0000673
so part of: YMR042W
location: 352603..353136
location: region:352603-353136:1
so has part: feature:352603-353136:1:exon

NP_013756.1
type: Protein
SIO_000068: ncbiprotein

S000004645
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352603-353136:1:exon

YMR043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FUN80
gene: MCM1
locus tag: YMR043W
gene synonym: FUN80
so part of: sequence
location: <353871..>354731
location: region:353871-354731:1
so has part: feature:353871-354731:1:exon
subclass of: SO_0000010

855060
type: Gene
SIO_000068: ncbigene

position:353871:1
position: 353871
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:354731:1
position: 354731
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353871-354731:1:exon

YMR043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FUN80
gene: MCM1
locus tag: YMR043W
gene synonym: FUN80
product: transcription factor MCM1
transcript id: NM_001182540.1
SIO_010081: YMR043W
subclass of: SO_0000673
so part of: YMR043W
location: <353871..>354731
location: region:353871-354731:1
so has part: feature:353871-354731:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:353871-354731:1:exon

YMR043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FUN80
gene: MCM1
locus tag: YMR043W
gene synonym: FUN80
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9121436]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12473677]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12738768|PMID:1752436|PMID:2673922]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11562353]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9121436]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12052870|PMID:9121436]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12473677]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [PMID:12509445|PMID:7739902|PMID:9121436|PMID:9490409]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19233144|PMID:9121436|PMID:11060038]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9490409]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8455631|PMID:16278448|PMID:1961765]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10594003]
experiment: EXISTENCE:mutant phenotype:GO:0031494 regulation of mating type switching [PMID:9620858]
experiment: EXISTENCE:mutant phenotype:GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [PMID:10594003|PMID:12509445|PMID:15118075]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7565744|PMID:8455631|PMID:12738768|PMID:16278448|PMI D:19233144|PMID:1961765|PMID:9171372]
experiment: EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12052870|PMID:12711672]
experiment: EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19233144]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12509445|PMID:12711672]
note: Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: transcription factor MCM1
translation: MSDIEEGTPTNNGQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGNDMQRQQPQQQQPQQQQQVLNAHANSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQQQHHTQNSQPQQQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQQQQQQPLTGIHQPHQQAFANAASPYLNAEQNAAYQQYFQEPQQGQY
SIO_010081: YMR043W
subclass of: SO_0000673
so part of: YMR043W
location: 353871..354731
location: region:353871-354731:1
so has part: feature:353871-354731:1:exon

NP_013757.1
type: Protein
SIO_000068: ncbiprotein

S000004646
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:353871-354731:1:exon

YMR044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IOC4
locus tag: YMR044W
so part of: sequence
location: <355384..>356811
location: region:355384-356811:1
so has part: feature:355384-356811:1:exon
subclass of: SO_0000010

855061
type: Gene
SIO_000068: ncbigene

position:355384:1
position: 355384
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356811:1
position: 356811
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:355384-356811:1:exon

YMR044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IOC4
locus tag: YMR044W
product: Ioc4p
transcript id: NM_001182541.1
SIO_010081: YMR044W
subclass of: SO_0000673
so part of: YMR044W
location: <355384..>356811
location: region:355384-356811:1
so has part: feature:355384-356811:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:355384-356811:1:exon

YMR044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IOC4
locus tag: YMR044W
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]
experiment: EXISTENCE:direct assay:GO:0036437 Isw1b complex [PMID:12482963]
experiment: EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]
experiment: EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:12482963]
note: Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
codon start: 1
product: Ioc4p
translation: MSEAIFQPTDIVLAKVKGFSAWPAMIIPNELIPDNILKTKPVSVHKGKSGSDKKANEDIDADMESEARDREQSEEEEDIEDFGESEANPEKFIIYTPVLKFRKNDTLKSTYCVKFFCDDSYIWVKPMDMKILTSEDCRKWLSGKQRKNKKLIPAYEMAMRGKNGIDIWEFVEYGSYGKPDEEEYVEEEEEENEPEKKAIRPTRSSSRQRQKRASETEKSEGGNSNKRKRVTRSTRQQAIDASEEEEEEEEEKVQEAVRKRPQRTKTKKVVVSKTKPNPKTKAKKEKPKPPKPIKYHFEDDEDWSIVGLGPQDLSIEKTMDPIAKKLSQKKNLEKHVEIKLDLEDKLAGINKLLCDVLCSAINQAVSIKDDFEIILDELQIALDTRGSRNEFITIFQSNNSLLLNFRILFNLRKRELNKWDLWDRFQDIFKHIYSYQFIPDTEDWQLEQNMEIEEMDREKPSFSEDVKEEESKVGA
SIO_010081: YMR044W
subclass of: SO_0000673
so part of: YMR044W
location: 355384..356811
location: region:355384-356811:1
so has part: feature:355384-356811:1:exon

NP_013758.1
type: Protein
SIO_000068: ncbiprotein

S000004647
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:355384-356811:1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YMRCTy1-3; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YMRCTy1-3
so part of: sequence
location: complement(357005..362918)
location: region:357005-362918:-1
so has part: feature:357005-362918:-1:region

S000007119
type: SGD
SIO_000068: sgd

position:357005:-1
position: 357005
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:362918:-1
position: 362918
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357005-362918:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(357005..357336)
location: region:357005-357336:-1
so has part: feature:357005-357336:-1:region

S000007109
type: SGD
SIO_000068: sgd

position:357336:-1
position: 357336
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357005-357336:-1:region

YMR045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR045C
so part of: sequence
location: complement(<357359..>362627)
location: region:357359-362627:-1
so has part: feature:357359-362627:-1:exon
subclass of: SO_0000010

855062
type: Gene
SIO_000068: ncbigene

position:357359:-1
position: 357359
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:362627:-1
position: 362627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357359-362627:-1:exon

YMR045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR045C
product: gag-pol fusion protein
transcript id: NM_001182542.2
SIO_010081: YMR045C
subclass of: SO_0000673
so part of: YMR045C
location: complement(<357359..>362627)
location: region:357359-362627:-1
so has part: feature:357359-362627:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:357359-362627:-1:exon

YMR045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR045C
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECEKVSTQANSQQPTTPLSSAVPENHHHASPQAAQVPLPQNGPYPQQRMMNTQQANISGWPVYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKSNMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFAPSQFLPPWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLATLHYNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRCIHMTVADLFSDIHSMYEEQQESKRNKSTHRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTFNNSPGPDNDLIRGSTTEPIQLKNTHDLHLGQELTESTVNHTNHSDDKLPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFENSQVTICLFVDDMVLFSKNLNSNKRIIDKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YMR045C
subclass of: SO_0000673
so part of: YMR045C
location: complement(join(357359..361321,361323..362627))
location: region:357359-362627:-1
so has part: feature:361323-362627:-1:exon
so has part: feature:357359-361321:-1:exon

NP_013759.1
type: Protein
SIO_000068: ncbiprotein

S000004648
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:361323-362627:-1:exon

position:361323:-1
position: 361323
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:357359-361321:-1:exon

position:361321:-1
position: 361321
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YMR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR046C
so part of: sequence
location: complement(<361305..>362627)
location: region:361305-362627:-1
so has part: feature:361305-362627:-1:exon
subclass of: SO_0000010

855063
type: Gene
SIO_000068: ncbigene

position:361305:-1
position: 361305
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:361305-362627:-1:exon

YMR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR046C
product: gag protein
transcript id: NM_001182543.1
SIO_010081: YMR046C
subclass of: SO_0000673
so part of: YMR046C
location: complement(<361305..>362627)
location: region:361305-362627:-1
so has part: feature:361305-362627:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:361305-362627:-1:exon

YMR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR046C
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECEKVSTQANSQQPTTPLSSAVPENHHHASPQAAQVPLPQNGPYPQQRMMNTQQANISGWPVYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKSNMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFAPSQFLPPWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLATLHYNGSTPADAFEAEVTNILDRLNNNGIPINNKVACQFIMRGLSGEYKFLRYARHRCIHMTVADLFSDIHSMYEEQQESKRNKSTHRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTFNNSPGPDNDLIRGSTTEPIQLKNTHDLHLRPGTY
SIO_010081: YMR046C
subclass of: SO_0000673
so part of: YMR046C
location: complement(361305..362627)
location: region:361305-362627:-1
so has part: feature:361305-362627:-1:exon

NP_013760.1
type: Protein
SIO_000068: ncbiprotein

S000004649
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:361305-362627:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(362587..362918)
location: region:362587-362918:-1
so has part: feature:362587-362918:-1:region

S000007110
type: SGD
SIO_000068: sgd

position:362587:-1
position: 362587
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362587-362918:-1:region

YNCM0020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0020W
so part of: sequence
location: 363064..363135
location: region:363064-363135:1
so has part: feature:363064-363135:1:exon
subclass of: SO_0000663

855065
type: Gene
SIO_000068: ncbigene

position:363064:1
position: 363064
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:363135:1
position: 363135
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:363064-363135:1:exon

YNCM0020W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0020W
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0020W
subclass of: SO_0000673
so part of: YNCM0020W
location: 363064..363135
location: region:363064-363135:1
so has part: feature:363064-363135:1:exon

S000006599
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:363064-363135:1:exon

YMR047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSP116
gene: NUP116
locus tag: YMR047C
gene synonym: NSP116
so part of: sequence
location: complement(<363364..>366705)
location: region:363364-366705:-1
so has part: feature:363364-366705:-1:exon
subclass of: SO_0000010

855066
type: Gene
SIO_000068: ncbigene

position:363364:-1
position: 363364
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:366705:-1
position: 366705
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:363364-366705:-1:exon

YMR047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSP116
gene: NUP116
locus tag: YMR047C
gene synonym: NSP116
product: FG-nucleoporin NUP116
transcript id: NM_001182544.1
SIO_010081: YMR047C
subclass of: SO_0000673
so part of: YMR047C
location: complement(<363364..>366705)
location: region:363364-366705:-1
so has part: feature:363364-366705:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:363364-366705:-1:exon

YMR047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSP116
gene: NUP116
locus tag: YMR047C
gene synonym: NSP116
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:1385442]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:14960378]
experiment: EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327|PMID:17875746]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308|PMID:9802895]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:8557738]
experiment: EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:9463388]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8557738|PMID:9802895]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
experiment: EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11104765]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:12917401|PMID:17803941|PMID:17418788]
note: FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication
codon start: 1
product: FG-nucleoporin NUP116
translation: MFGVSRGAFPSATTQPFGSTGSTFGGQQQQQQPVANTSAFGLSQQTNTTQAPAFGNFGNQTSNSPFGMSGSTTANGTPFGQSQLTNNNASGSIFGGMGNNTALSAGSASVVPNSTAGTSIKPFTTFEEKDPTTGVINVFQSITCMPEYRNFSFEELRFQDYQAGRKFGTSQNGTGTTFNNPQGTTNTGFGIMGNNNSTTSATTGGLFGQKPATGMFGTGTGSGGGFGSGATNSTGLFGSSTNLSGNSAFGANKPATSGGLFGNTTNNPTNGTNNTGLFGQQNSNTNGGLFGQQQNSFGANNVSNGGAFGQVNRGAFPQQQTQQGSGGIFGQSNANANGGAFGQQQGTGALFGAKPASGGLFGQSAGSKAFGMNTNPTGTTGGLFGQTNQQQSGGGLFGQQQNSNAGGLFGQNNQSQNQSGLFGQQNSSNAFGQPQQQGGLFGSKPAGGLFGQQQGASTFASGNAQNNSIFGQNNQQQQSTGGLFGQQNNQSQSQPGGLFGQTNQNNNQPFGQNGLQQPQQNNSLFGAKPTGFGNTSLFSNSTTNQSNGISGNNLQQQSGGLFQNKQQPASGGLFGSKPSNTVGGGLFGNNQVANQNNPASTSGGLFGSKPATGSLFGGTNSTAPNASSGGIFGSNNASNTAATTNSTGLFGNKPVGAGASTSAGGLFGNNNNSSLNNSNGSTGLFGSNNTSQSTNAGGLFQNNTSTNTSGGGLFSQPSQSMAQSQNALQQQQQQQRLQIQNNNPYGTNELFSKATVTNTVSYPIQPSATKIKADERKKASLTNAYKMIPKTLFTAKLKTNNSVMDKAQIKVDPKLSISIDKKNNQIAISNQQEENLDESILKASELLFNPDKRSFKNLINNRKMLIASEEKNNGSQNNDMNFKSKSEEQETILGKPKMDEKETANGGERMVLSSKNDGEDSATKHHSRNMDEENKENVADLQKQEYSEDDKKAVFADVAEKDASFINENYYISPSLDTLSSYSLLQLRKVPHLVVGHKSYGKIEFLEPVDLAGIPLTSLGGVIITFEPKTCIIYANLPNRPKRGEGINVRARITCFNCYPVDKSTRKPIKDPNHQLVKRHIERLKKNPNSKFESYDADSGTYVFIVNHAAEQT
SIO_010081: YMR047C
subclass of: SO_0000673
so part of: YMR047C
location: complement(363364..366705)
location: region:363364-366705:-1
so has part: feature:363364-366705:-1:exon

NP_013762.1
type: Protein
SIO_000068: ncbiprotein

S000004650
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:363364-366705:-1:exon

YMR048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSM3
locus tag: YMR048W
so part of: sequence
location: <366981..>367934
location: region:366981-367934:1
so has part: feature:366981-367934:1:exon
subclass of: SO_0000010

855067
type: Gene
SIO_000068: ncbigene

position:366981:1
position: 366981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:367934:1
position: 367934
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366981-367934:1:exon

YMR048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSM3
locus tag: YMR048W
product: Csm3p
transcript id: NM_001182545.1
SIO_010081: YMR048W
subclass of: SO_0000673
so part of: YMR048W
location: <366981..>367934
location: region:366981-367934:1
so has part: feature:366981-367934:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366981-367934:1:exon

YMR048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSM3
locus tag: YMR048W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]
experiment: EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]
experiment: EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]
experiment: EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:16103218|PMID:16418273]
experiment: EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]
experiment: EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0048478 replication fork protection [PMID:16418273]
note: Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
codon start: 1
product: Csm3p
translation: MDQDFDSLLLGFNDSDSVQKDPTVPNGLDGSVVDPTIADPTAITARKRRPQVKLTAEKLLSDKGLPYVLKNAHKRIRISSKKNSYDNLSNIIQFYQLWAHELFPKAKFKDFMKICQTVGKTDPVLREYRVSLFRDEMGMSFDVGTRETGQDLERQSPMVEEHVTSAEERPIVADSFAQDKRNVNNVDYDNDEDDDIYHLSYRNRRGRVLDERGNNETVLNNVVPPKEDLDALLKTFRVQGPVGLEENEKKLLLGWLDAHRKMEKGSMTEEDVQLIQSLEEWEMNDIEGQHTHYDLLPGGDEFGVDQDELDAMKEMGF
SIO_010081: YMR048W
subclass of: SO_0000673
so part of: YMR048W
location: 366981..367934
location: region:366981-367934:1
so has part: feature:366981-367934:1:exon

NP_013763.1
type: Protein
SIO_000068: ncbiprotein

S000004651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366981-367934:1:exon

YMR049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERB1
locus tag: YMR049C
so part of: sequence
location: complement(<368094..>370517)
location: region:368094-370517:-1
so has part: feature:368094-370517:-1:exon
subclass of: SO_0000010

855068
type: Gene
SIO_000068: ncbigene

position:368094:-1
position: 368094
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370517:-1
position: 370517
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368094-370517:-1:exon

YMR049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERB1
locus tag: YMR049C
product: Erb1p
transcript id: NM_001182546.1
SIO_010081: YMR049C
subclass of: SO_0000673
so part of: YMR049C
location: complement(<368094..>370517)
location: region:368094-370517:-1
so has part: feature:368094-370517:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368094-370517:-1:exon

YMR049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERB1
locus tag: YMR049C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]
experiment: EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0070545 PeBoW complex [PMID:16287855]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11522832]
experiment: EXISTENCE:physical interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16287855]
experiment: EXISTENCE:physical interaction:GO:0070545 PeBoW complex [PMID:16287855]
note: Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; binds RNA via its C-terminal domain; homologous to mammalian Bop1
codon start: 1
product: Erb1p
translation: MMAKNNKTTEAKMSKKRAASEESDVEEDEDKLLSVDGLIDAEASESDEDDDEYESAVEEKESSSDKEAQDDSDDDSDAELNKLLAEEEGDGEEDYDSSEFSDDTTSLTDRLSGVKLQTIVDPNIYSKYADGSDRIIKPEINPVYDSDDSDAETQNTIGNIPLSAYDEMPHIGYDINGKRIMRPAKGSALDQLLDSIELPEGWTGLLDKNSGSSLNLTKEELELISKIQRNEQTDDSINPYEPLIDWFTRHEEVMPLTAVPEPKRRFVPSKNEAKRVMKIVRAIREGRIIPPKKLKEMKEKEKIENYQYDLWGDSTETNDHVMHLRAPKLPPPTNEESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT
SIO_010081: YMR049C
subclass of: SO_0000673
so part of: YMR049C
location: complement(368094..370517)
location: region:368094-370517:-1
so has part: feature:368094-370517:-1:exon

NP_013764.1
type: Protein
SIO_000068: ncbiprotein

S000004652
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368094-370517:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1312; Autonomously Replicating Sequence
so part of: sequence
location: 371001..371105
location: region:371001-371105:1
so has part: feature:371001-371105:1:region

S000118371
type: SGD
SIO_000068: sgd

position:371001:1
position: 371001
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:371105:1
position: 371105
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371001-371105:1:region

YNCM0021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0021C
so part of: sequence
location: complement(372445..372518)
location: region:372445-372518:-1
so has part: feature:372445-372518:-1:exon
subclass of: SO_0000663

855069
type: Gene
SIO_000068: ncbigene

position:372445:-1
position: 372445
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:372518:-1
position: 372518
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372445-372518:-1:exon

YNCM0021C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0021C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0021C
subclass of: SO_0000673
so part of: YNCM0021C
location: complement(372445..372518)
location: region:372445-372518:-1
so has part: feature:372445-372518:-1:exon

S000006763
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372445-372518:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YMRCTy1-4; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YMRCTy1-4
so part of: sequence
location: complement(372697..378622)
location: region:372697-378622:-1
so has part: feature:372697-378622:-1:region

S000007120
type: SGD
SIO_000068: sgd

position:372697:-1
position: 372697
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:378622:-1
position: 378622
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372697-378622:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(372697..373034)
location: region:372697-373034:-1
so has part: feature:372697-373034:-1:region

S000007111
type: SGD
SIO_000068: sgd

position:373034:-1
position: 373034
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372697-373034:-1:region

YMR050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR050C
so part of: sequence
location: complement(<373057..>378325)
location: region:373057-378325:-1
so has part: feature:373057-378325:-1:exon
subclass of: SO_0000010

855070
type: Gene
SIO_000068: ncbigene

position:373057:-1
position: 373057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:378325:-1
position: 378325
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373057-378325:-1:exon

YMR050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR050C
product: gag-pol fusion protein
transcript id: NM_001182547.2
SIO_010081: YMR050C
subclass of: SO_0000673
so part of: YMR050C
location: complement(<373057..>378325)
location: region:373057-378325:-1
so has part: feature:373057-378325:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:373057-378325:-1:exon

YMR050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR050C
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YMR050C
subclass of: SO_0000673
so part of: YMR050C
location: complement(join(373057..377019,377021..378325))
location: region:373057-378325:-1
so has part: feature:377021-378325:-1:exon
so has part: feature:373057-377019:-1:exon

NP_013765.1
type: Protein
SIO_000068: ncbiprotein

S000004653
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:377021-378325:-1:exon

position:377021:-1
position: 377021
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:373057-377019:-1:exon

position:377019:-1
position: 377019
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YMR051C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR051C
so part of: sequence
location: complement(<377003..>378325)
location: region:377003-378325:-1
so has part: feature:377003-378325:-1:exon
subclass of: SO_0000010

855071
type: Gene
SIO_000068: ncbigene

position:377003:-1
position: 377003
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:377003-378325:-1:exon

YMR051C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR051C
product: gag protein
transcript id: NM_001182548.1
SIO_010081: YMR051C
subclass of: SO_0000673
so part of: YMR051C
location: complement(<377003..>378325)
location: region:377003-378325:-1
so has part: feature:377003-378325:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:377003-378325:-1:exon

YMR051C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR051C
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YMR051C
subclass of: SO_0000673
so part of: YMR051C
location: complement(377003..378325)
location: region:377003-378325:-1
so has part: feature:377003-378325:-1:exon

NP_013766.1
type: Protein
SIO_000068: ncbiprotein

S000004654
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:377003-378325:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(378285..378622)
location: region:378285-378622:-1
so has part: feature:378285-378622:-1:region

S000007112
type: SGD
SIO_000068: sgd

position:378285:-1
position: 378285
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378285-378622:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(378727..379061)
location: region:378727-379061:-1
so has part: feature:378727-379061:-1:region

S000007113
type: SGD
SIO_000068: sgd

position:378727:-1
position: 378727
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:379061:-1
position: 379061
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378727-379061:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 379072..379198
location: region:379072-379198:1
so has part: feature:379072-379198:1:region

S000007121
type: SGD
SIO_000068: sgd

position:379072:1
position: 379072
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:379198:1
position: 379198
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379072-379198:1:region

YNCM0022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0022C
so part of: sequence
location: complement(379303..379408)
location: region:379303-379408:-1
so has part: feature:379303-379408:-1:exon
subclass of: SO_0000663

855072
type: Gene
SIO_000068: ncbigene

position:379303:-1
position: 379303
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:379408:-1
position: 379408
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379303-379408:-1:exon

YNCM0022C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0022C
product: tRNA-Trp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Tryptophan tRNA (tRNA-Trp), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0022C
subclass of: SO_0000673
so part of: YNCM0022C
location: complement(join(379303..379338,379373..379408))
location: region:379303-379408:-1
so has part: feature:379373-379408:-1:exon
so has part: feature:379303-379338:-1:exon

S000006775
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:379373-379408:-1:exon

position:379373:-1
position: 379373
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:379303-379338:-1:exon

position:379338:-1
position: 379338
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YMR052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAR3
locus tag: YMR052W
so part of: sequence
location: <379586..>380200
location: region:379586-380200:1
so has part: feature:379586-380200:1:exon
subclass of: SO_0000010

855073
type: Gene
SIO_000068: ncbigene

position:379586:1
position: 379586
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:380200:1
position: 380200
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379586-380200:1:exon

YMR052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAR3
locus tag: YMR052W
product: Far3p
transcript id: NM_001182550.1
SIO_010081: YMR052W
subclass of: SO_0000673
so part of: YMR052W
location: <379586..>380200
location: region:379586-380200:1
so has part: feature:379586-380200:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:379586-380200:1:exon

YMR052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAR3
locus tag: YMR052W
experiment: EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:22782902]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]
experiment: EXISTENCE:mutant phenotype:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]
note: hypothetical protein; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
codon start: 1
product: Far3p
translation: MNSGGSDSFDYLLQLTKALSAECRANRQETDRIELLLKRLAKQSGISYDNLSKNIIPDSWKDNASQKASPPTEAQKLISENFKLIYEIEKQEYFNTKAVALINNINEHFSYIKNFIDEQNAIRERNIATFSSEKLDERNKSLQQNYESLKTENEETKKKLHSIIKQFEKLLKEVDWDRISKDSRDYSRFKKQLEYLQDTYQVLK
SIO_010081: YMR052W
subclass of: SO_0000673
so part of: YMR052W
location: 379586..380200
location: region:379586-380200:1
so has part: feature:379586-380200:1:exon

NP_013767.1
type: Protein
SIO_000068: ncbiprotein

S000004656
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:379586-380200:1:exon

YMR053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STB2
locus tag: YMR053C
so part of: sequence
location: complement(<380346..>382898)
location: region:380346-382898:-1
so has part: feature:380346-382898:-1:exon
subclass of: SO_0000010

855075
type: Gene
SIO_000068: ncbigene

position:380346:-1
position: 380346
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382898:-1
position: 382898
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:380346-382898:-1:exon

YMR053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STB2
locus tag: YMR053C
product: Stb2p
transcript id: NM_001182551.1
SIO_010081: YMR053C
subclass of: SO_0000673
so part of: YMR053C
location: complement(<380346..>382898)
location: region:380346-382898:-1
so has part: feature:380346-382898:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380346-382898:-1:exon

YMR053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STB2
locus tag: YMR053C
experiment: EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9393435]
experiment: EXISTENCE:physical interaction:GO:0070822 Sin3-type complex [PMID:9393435]
note: Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication
codon start: 1
product: Stb2p
translation: MVMADTIATGDKTSQFDGKHMQDLERIYSTRDTLDDNFFGERGQKDANGDYYDELNNEETNYSGSSYYGHSDDSEVVGLIKNDTVSQLPPLDSFIFPDSRALFLLDLGNYADLTYEEIIVHGFEIYIVEQWVACRNLSTLITSYTGNSQDTISGVRVVLPKDTSMWPGRFRLYFEELMEFARPKFTPKGTLFITNLSGVSFGLNLLHVECGDLRTIWKDFEVNFDLKNLHCGGRSANLLCPPTMASLDKFSQLFKIPTNGFIAQYPQMIQQQQPRLPEEEYKTVGNSKCRNTDSKSPVVEMVTLIQISLSYFNLLSKNYQTDGLLCEDTKRAIDEWWETYGKLYLGTEKPRNECTLGPTTVAGLISLILCCYFKLMIENCISSKDPFDEAGFFQGIYNFQKKHGLNKRKSRVYLDPRTLEKLFEVTAKVSSKDIFKLKKMVTSTVQDIIGKGNPINLSHKILTTDLDTLIHNIHGGSVGLLWKGKGHPRKCCTDISNEEFLKFNYQRGDPDGQIREREMLLEKFRLERIAYAQKHASKKVSSSSLDTSEDIGRTNAMPSSATVSSMFPNYDNTKYAYNFGINKLYQGEYYRRNSFPYCKDRTHDNIYEDLSELKEKSSRLYRCNSSSAVQNIVEKWDLPFDPSVVRIARDLLRMKYDIQAQQHIQEMDEHYMGKLNKEGTVGQYSKFNERYKRLQELYKKYSDGAKVFEGRFEDIDNKQQLLLHEMQELNSLSSRLKYDMRILEVRVRDIESSVAQFDSKLIGLKSSLQGQGKTGICSAIDPKSDKDEYDRCVNDLMTTNNPTYEALCLKMLSRRYFKDLKNDTVGWFRWLFGNNSLHNNASEDDRGIRV
SIO_010081: YMR053C
subclass of: SO_0000673
so part of: YMR053C
location: complement(380346..382898)
location: region:380346-382898:-1
so has part: feature:380346-382898:-1:exon

NP_013769.1
type: Protein
SIO_000068: ncbiprotein

S000004657
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380346-382898:-1:exon

YMR054W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STV1
locus tag: YMR054W
so part of: sequence
location: <383303..>385975
location: region:383303-385975:1
so has part: feature:383303-385975:1:exon
subclass of: SO_0000010

855076
type: Gene
SIO_000068: ncbigene

position:383303:1
position: 383303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:385975:1
position: 385975
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:383303-385975:1:exon

YMR054W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STV1
locus tag: YMR054W
product: H(+)-transporting V0 sector ATPase subunit a
transcript id: NM_001182552.1
SIO_010081: YMR054W
subclass of: SO_0000673
so part of: YMR054W
location: <383303..>385975
location: region:383303-385975:1
so has part: feature:383303-385975:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:383303-385975:1:exon

YMR054W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STV1
locus tag: YMR054W
experiment: EXISTENCE:direct assay:GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain [PMID:7514599]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11592965]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11948198|PMID:11592965]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:28720663]
experiment: EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11278748|PMID:7514599]
experiment: EXISTENCE:genetic interaction:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:7514599]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11278748]
experiment: EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:28720663]
note: Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway
codon start: 1
product: H(+)-transporting V0 sector ATPase subunit a
translation: MNQEEAIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVERMVGFLNEVVEKHAAETWKYILHIDDEGNDIAQPDMADLINTMEPLSLENVNDMVKEITDCESRARQLDESLDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLSDAFSFDDETPQDRGALGNDLTRNQSVEDLSFLEQGYQHRYMITGSIRRTKVDILNRILWRLLRGNLIFQNFPIEEPLLEGKEKVEKDCFIIFTHGETLLKKVKRVIDSLNGKIVSLNTRSSELVDTLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQESQGLIAEGWVPSTELIHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKEINAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRDEIFDMAFTGRYVLLLMGAFSVYTGLLYNDIFSKSMTIFKSGWQWPSTFRKGESIEAKKTGVYPFGLDFAWHGTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLSWAIVYKWSKDWIKDDKPAPGLLNMLINMFLAPGTIDDQLYSGQAKLQVVLLLAALVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQGMIISDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE
SIO_010081: YMR054W
subclass of: SO_0000673
so part of: YMR054W
location: 383303..385975
location: region:383303-385975:1
so has part: feature:383303-385975:1:exon

NP_013770.1
type: Protein
SIO_000068: ncbiprotein

S000004658
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:383303-385975:1:exon

YMR055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAC7
gene: BUB2
locus tag: YMR055C
gene synonym: PAC7
so part of: sequence
location: complement(<386101..>387021)
location: region:386101-387021:-1
so has part: feature:386101-387021:-1:exon
subclass of: SO_0000010

855077
type: Gene
SIO_000068: ncbigene

position:386101:-1
position: 386101
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:387021:-1
position: 387021
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:386101-387021:-1:exon

YMR055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAC7
gene: BUB2
locus tag: YMR055C
gene synonym: PAC7
product: Bub2p
transcript id: NM_001182553.1
SIO_010081: YMR055C
subclass of: SO_0000673
so part of: YMR055C
location: complement(<386101..>387021)
location: region:386101-387021:-1
so has part: feature:386101-387021:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:386101-387021:-1:exon

YMR055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAC7
gene: BUB2
locus tag: YMR055C
gene synonym: PAC7
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12048186|PMID:18667533|PMID:25658911]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10220406|PMID:10352016]
experiment: EXISTENCE:direct assay:GO:1990334 Bfa1-Bub2 complex [PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:16039591|PMID:25658911]
experiment: EXISTENCE:mutant phenotype:GO:1902543 negative regulation of protein localization to mitotic spindle pole body [PMID:25658911]
experiment: EXISTENCE:physical interaction:GO:1990334 Bfa1-Bub2 complex [PMID:11493673]
note: Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
codon start: 1
product: Bub2p
translation: MTSIEDLISNPPLLLHSSLSQLRYLILSEGLPISEDKQQQRTRCYVWTVLSQTSMEASTQRYLALLKLGPPSTTIYQKIKNDTSRTFQTDPNFRNRVSEDALIRCLSCFAWQTQQRRQKTRFGRIPVSTYVQGMNVLLAPLLYSCPSEPMAYQLFTKLCYEMIPTYLTKNLNGAQNGAKLLDISLRIIDPKLSKFLSDNLLTAEIYGMPSILTLSSCNKPLDQVIKLWDFMFAYGFHMNILFVVAFLVKMRSKVFKSDSPVNLLRQFPDFDADEIIRLGVGFIAKIPAQIYDLLVDHLTDPDIYIP
SIO_010081: YMR055C
subclass of: SO_0000673
so part of: YMR055C
location: complement(386101..387021)
location: region:386101-387021:-1
so has part: feature:386101-387021:-1:exon

NP_013771.1
type: Protein
SIO_000068: ncbiprotein

S000004659
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:386101-387021:-1:exon

YMR056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAC1
locus tag: YMR056C
so part of: sequence
location: complement(<387315..>388244)
location: region:387315-388244:-1
so has part: feature:387315-388244:-1:exon
subclass of: SO_0000010

855078
type: Gene
SIO_000068: ncbigene

position:387315:-1
position: 387315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388244:-1
position: 388244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387315-388244:-1:exon

YMR056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAC1
locus tag: YMR056C
product: ADP/ATP carrier protein AAC1
transcript id: NM_001182554.1
SIO_010081: YMR056C
subclass of: SO_0000673
so part of: YMR056C
location: complement(<387315..>388244)
location: region:387315-388244:-1
so has part: feature:387315-388244:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387315-388244:-1:exon

YMR056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAC1
locus tag: YMR056C
experiment: EXISTENCE:direct assay:GO:0005471 ATP:ADP antiporter activity [PMID:2167309]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:22842922|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12740376]
experiment: EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:18728780]
experiment: EXISTENCE:genetic interaction:GO:0006839 mitochondrial transport [PMID:2167309]
experiment: EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:2167309]
experiment: EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:18728780]
note: Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
codon start: 1
product: ADP/ATP carrier protein AAC1
translation: MSHTETQTQQSHFGVDFLMGGVSAAIAKTGAAPIERVKLLMQNQEEMLKQGSLDTRYKGILDCFKRTATHEGIVSFWRGNTANVLRYFPTQALNFAFKDKIKSLLSYDRERDGYAKWFAGNLFSGGAAGGLSLLFVYSLDYARTRLAADARGSKSTSQRQFNGLLDVYKKTLKTDGLLGLYRGFVPSVLGIIVYRGLYFGLYDSFKPVLLTGALEGSFVASFLLGWVITMGASTASYPLDTVRRRMMMTSGQTIKYDGALDCLRKIVQKEGAYSLFKGCGANIFRGVAAAGVISLYDQLQLIMFGKKFK
SIO_010081: YMR056C
subclass of: SO_0000673
so part of: YMR056C
location: complement(387315..388244)
location: region:387315-388244:-1
so has part: feature:387315-388244:-1:exon

NP_013772.1
type: Protein
SIO_000068: ncbiprotein

S000004660
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387315-388244:-1:exon

YMR058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FET3
locus tag: YMR058W
so part of: sequence
location: <388822..>390732
location: region:388822-390732:1
so has part: feature:388822-390732:1:exon
subclass of: SO_0000010

855080
type: Gene
SIO_000068: ncbigene

position:388822:1
position: 388822
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:390732:1
position: 390732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388822-390732:1:exon

YMR058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FET3
locus tag: YMR058W
product: ferroxidase FET3
transcript id: NM_001182556.1
SIO_010081: YMR058W
subclass of: SO_0000673
so part of: YMR058W
location: <388822..>390732
location: region:388822-390732:1
so has part: feature:388822-390732:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:388822-390732:1:exon

YMR058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FET3
locus tag: YMR058W
EC number: 1.16.3.1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004322 ferroxidase activity [PMID:8599111|PMID:9722559]
experiment: EXISTENCE:direct assay:GO:0005381 iron ion transmembrane transporter activity [PMID:16700543]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16700543|PMID:9162052]
experiment: EXISTENCE:direct assay:GO:0033573 high-affinity iron permease complex [PMID:16522632]
experiment: EXISTENCE:genetic interaction:GO:0034755 iron ion transmembrane transport [PMID:8599111]
experiment: EXISTENCE:genetic interaction:GO:1901684 arsenate ion transmembrane transport [PMID:23295455]
experiment: EXISTENCE:mutant phenotype:GO:0033215 reductive iron assimilation [PMID:16700543]
experiment: EXISTENCE:mutant phenotype:GO:0034755 iron ion transmembrane transport [PMID:16700543|PMID:8293473|PMID:8599111]
experiment: EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:12954629]
note: Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
codon start: 1
product: ferroxidase FET3
translation: MTNALLSIAVLLFSMLSLAQAETHTFNWTTGWDYRNVDGLKSRPVITCNGQFPWPDITVNKGDRVQIYLTNGMNNTNTSMHFHGLFQNGTASMDGVPFLTQCPIAPGSTMLYNFTVDYNVGTYWYHSHTDGQYEDGMKGLFIIKDDSFPYDYDEELSLSLSEWYHDLVTDLTKSFMSVYNPTGAEPIPQNLIVNNTMNLTWEVQPDTTYLLRIVNVGGFVSQYFWIEDHEMTVVEIDGITTEKNVTDMLYITVAQRYTVLVHTKNDTDKNFAIMQKFDDTMLDVIPSDLQLNATSYMVYNKTAALPTQNYVDSIDNFLDDFYLQPYEKEAIYGEPDHVITVDVVMDNLKNGVNYAFFNNITYTAPKVPTLMTVLSSGDQANNSEIYGSNTHTFILEKDEIVEIVLNNQDTGTHPFHLHGHAFQTIQRDRTYDDALGEVPHSFDPDNHPAFPEYPMRRDTLYVRPQSNFVIRFKADNPGVWFFHCHIEWHLLQGLGLVLVEDPFGIQDAHSQQLSENHLEVCQSCSVATEGNAAANTLDLTDLTGENVQHAFIPTGFTKKGIIAMTFSCFAGILGIITIAIYGMMDMEDATEKVIRDLHVDPEVLLNEVDENEERQVNEDRHSTEKHQFLTKAKRFF
SIO_010081: YMR058W
subclass of: SO_0000673
so part of: YMR058W
location: 388822..390732
location: region:388822-390732:1
so has part: feature:388822-390732:1:exon

NP_013774.1
type: Protein
SIO_000068: ncbiprotein

S000004662
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:388822-390732:1:exon

YMR059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEN15
locus tag: YMR059W
so part of: sequence
location: <391099..>391485
location: region:391099-391485:1
so has part: feature:391099-391485:1:exon
subclass of: SO_0000010

855081
type: Gene
SIO_000068: ncbigene

position:391099:1
position: 391099
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:391485:1
position: 391485
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:391099-391485:1:exon

YMR059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEN15
locus tag: YMR059W
product: Sen15p
transcript id: NM_001182557.1
SIO_010081: YMR059W
subclass of: SO_0000673
so part of: YMR059W
location: <391099..>391485
location: region:391099-391485:1
so has part: feature:391099-391485:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:391099-391485:1:exon

YMR059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEN15
locus tag: YMR059W
experiment: EXISTENCE:direct assay:GO:0000213 tRNA-intron endonuclease activity [PMID:9200603]
experiment: EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]
experiment: EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]
note: Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface
codon start: 1
product: Sen15p
translation: MATTDIISLVKNNLLYFQMWTEVEILQDDLSWKGNSLRLLRGRPPHKLSNDVDTEHENSLSSPRPLEFILPINMSQYKENFLTLECLSQTFTHLCSPSTERILLAIINDDGTIVYYFVYKGVRKPKRN
SIO_010081: YMR059W
subclass of: SO_0000673
so part of: YMR059W
location: 391099..391485
location: region:391099-391485:1
so has part: feature:391099-391485:1:exon

NP_013775.2
type: Protein
SIO_000068: ncbiprotein

S000004663
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:391099-391485:1:exon

YMR060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAS37
alternative label: PET3027
alternative label: TOM37
gene: SAM37
locus tag: YMR060C
gene synonym: MAS37; PET3027; TOM37
so part of: sequence
location: complement(<391532..>392515)
location: region:391532-392515:-1
so has part: feature:391532-392515:-1:exon
subclass of: SO_0000010

855082
type: Gene
SIO_000068: ncbigene

position:391532:-1
position: 391532
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:392515:-1
position: 392515
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:391532-392515:-1:exon

YMR060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAS37
alternative label: PET3027
alternative label: TOM37
gene: SAM37
locus tag: YMR060C
gene synonym: MAS37; PET3027; TOM37
product: SAM complex subunit SAM37
transcript id: NM_001182558.1
SIO_010081: YMR060C
subclass of: SO_0000673
so part of: YMR060C
location: complement(<391532..>392515)
location: region:391532-392515:-1
so has part: feature:391532-392515:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:391532-392515:-1:exon

YMR060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAS37
alternative label: PET3027
alternative label: TOM37
gene: SAM37
locus tag: YMR060C
gene synonym: MAS37; PET3027; TOM37
experiment: EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:12891361]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:21299651]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:18039934]
experiment: EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:12891361|PMID:18039934]
note: Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
codon start: 1
product: SAM complex subunit SAM37
translation: MVKGSVHLWGKDGKASLISVDSIALVWFIKLCTSEEAKSMVAGLQIVFSNNTDLSSDGKLPVLILDNGTKVSGYVNIVQFLHKNICTSKYEKGTDYEEDLAIVRKKDRLLEYSLLNYVDVEISRLTDYQLFLNTKNYNEYTKKLFSKLLYFPMWYNTPLQLRSQARENCEEIIGSLTLEDDEEFVESKAMESASQLAQSKTFKIAHKNKIKGKQELQQVKYNLQFDNRLQSCVSNWLAARKKLDDSVILSSDLLFLANLYVQLGLPDGNRIRSKLEQTFGSELLNSMSNKIDDFVHRPSNNLEQRDPQFREQGNVVMSLYNLACKYI
SIO_010081: YMR060C
subclass of: SO_0000673
so part of: YMR060C
location: complement(391532..392515)
location: region:391532-392515:-1
so has part: feature:391532-392515:-1:exon

NP_013776.1
type: Protein
SIO_000068: ncbiprotein

S000004664
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:391532-392515:-1:exon

YMR061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RNA14
locus tag: YMR061W
so part of: sequence
location: <392755..>394788
location: region:392755-394788:1
so has part: feature:392755-394788:1:exon
subclass of: SO_0000010

855083
type: Gene
SIO_000068: ncbigene

position:392755:1
position: 392755
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394788:1
position: 394788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392755-394788:1:exon

YMR061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RNA14
locus tag: YMR061W
product: cleavage polyadenylation factor subunit RNA14
transcript id: NM_001182559.1
SIO_010081: YMR061W
subclass of: SO_0000673
so part of: YMR061W
location: <392755..>394788
location: region:392755-394788:1
so has part: feature:392755-394788:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392755-394788:1:exon

YMR061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RNA14
locus tag: YMR061W
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15215336]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10660071|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10660071]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11344258]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11344258]
experiment: EXISTENCE:mutant phenotype:GO:0072423 response to DNA damage checkpoint signaling [PMID:24603480]
experiment: EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]
note: Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: cleavage polyadenylation factor subunit RNA14
translation: MSSSTTPDLLYPSADKVAEPSDNIHGDELRLRERIKDNPTNILSYFQLIQYLETQESYAKVREVYEQFHNTFPFYSPAWTLQLKGELARDEFETVEKILAQCLSGKLENNDLSLWSTYLDYIRRKNNLITGGQEARAVIVKAFQLVMQKCAIFEPKSSSFWNEYLNFLEQWKPFNKWEEQQRIDMLREFYKKMLCVPFDNLEKMWNRYTQWEQEINSLTARKFIGELSAEYMKARSLYQEWLNVTNGLKRASPINLRTANKKNIPQPGTSDSNIQQLQIWLNWIKWERENKLMLSEDMLSQRISYVYKQGIQYMIFSAEMWYDYSMYISENSDRQNILYTALLANPDSPSLTFKLSECYELDNDSESVSNCFDKCTQTLLSQYKKIASDVNSGEDNNTEYEQELLYKQREKLTFVFCVYMNTMKRISGLSAARTVFGKCRKLKRILTHDVYVENAYLEFQNQNDYKTAFKVLELGLKYFQNDGVYINKYLDFLIFLNKDSQIKTLFETSVEKVQDLTQLKEIYKKMISYESKFGNLNNVYSLEKRFFERFPQENLIEVFTSRYQIQNSNLIKKLELTYMYNEEEDSYFSSGNGDGHHGSYNMSSSDRKRLMEETGNNGNFSNKKFKRDSELPTEVLDLLSVIPKRQYFNTNLLDAQKLVNFLNDQVEIPTVESTKSG
SIO_010081: YMR061W
subclass of: SO_0000673
so part of: YMR061W
location: 392755..394788
location: region:392755-394788:1
so has part: feature:392755-394788:1:exon

NP_013777.1
type: Protein
SIO_000068: ncbiprotein

S000004665
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392755-394788:1:exon

YMR062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECM40
gene: ARG7
locus tag: YMR062C
gene synonym: ECM40
so part of: sequence
location: complement(<395054..>396379)
location: region:395054-396379:-1
so has part: feature:395054-396379:-1:exon
subclass of: SO_0000010

855084
type: Gene
SIO_000068: ncbigene

position:395054:-1
position: 395054
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:396379:-1
position: 396379
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:395054-396379:-1:exon

YMR062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECM40
gene: ARG7
locus tag: YMR062C
gene synonym: ECM40
product: glutamate N-acetyltransferase
transcript id: NM_001182560.1
SIO_010081: YMR062C
subclass of: SO_0000673
so part of: YMR062C
location: complement(<395054..>396379)
location: region:395054-396379:-1
so has part: feature:395054-396379:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:395054-396379:-1:exon

YMR062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECM40
gene: ARG7
locus tag: YMR062C
gene synonym: ECM40
EC number: 2.3.1.1
EC number: 2.3.1.35
experiment: EXISTENCE:direct assay:GO:0004042 acetyl-CoA:L-glutamate N-acetyltransferase activity [PMID:9428669]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]
experiment: EXISTENCE:direct assay:GO:0006592 ornithine biosynthetic process [PMID:9428669]
note: Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
codon start: 1
product: glutamate N-acetyltransferase
translation: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
SIO_010081: YMR062C
subclass of: SO_0000673
so part of: YMR062C
location: complement(395054..396379)
location: region:395054-396379:-1
so has part: feature:395054-396379:-1:exon

NP_013778.1
type: Protein
SIO_000068: ncbiprotein

S000004666
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:395054-396379:-1:exon

YMR063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIM9
locus tag: YMR063W
so part of: sequence
location: <397077..>397796
location: region:397077-397796:1
so has part: feature:397077-397796:1:exon
subclass of: SO_0000010

855085
type: Gene
SIO_000068: ncbigene

position:397077:1
position: 397077
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397796:1
position: 397796
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397077-397796:1:exon

YMR063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIM9
locus tag: YMR063W
product: Rim9p
transcript id: NM_001182561.1
SIO_010081: YMR063W
subclass of: SO_0000673
so part of: YMR063W
location: <397077..>397796
location: region:397077-397796:1
so has part: feature:397077-397796:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397077-397796:1:exon

YMR063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIM9
locus tag: YMR063W
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:33002606]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8417990]
note: Plasma membrane hypothetical protein; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI
codon start: 1
product: Rim9p
translation: MVSMIHIVVFLLAITTMFEILPLITVPVTKYLSLSSFRNHYYGLFGWCVRGQNQELMCTKMKIGYDSTDVDSSGHVLTLPSNSKVVVSNLLVVHPISLAFTGTLLILAVIIMVTPLGDSPEMLLFTALFSLPTFMLCLLCFLVDILLFISKLDWPGWLMLAATISVALCCSMLWVMRRVVSVKKYESQQSIAHACSMEQYSISDIYQSKQNGNSSEYEVAPTHTDSLIAPEVTYRGFIE
SIO_010081: YMR063W
subclass of: SO_0000673
so part of: YMR063W
location: 397077..397796
location: region:397077-397796:1
so has part: feature:397077-397796:1:exon

NP_013779.1
type: Protein
SIO_000068: ncbiprotein

S000004667
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397077-397796:1:exon

YMR064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NCA1
gene: AEP1
locus tag: YMR064W
gene synonym: NCA1
so part of: sequence
location: <397903..>399459
location: region:397903-399459:1
so has part: feature:397903-399459:1:exon
subclass of: SO_0000010

855086
type: Gene
SIO_000068: ncbigene

position:397903:1
position: 397903
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:399459:1
position: 399459
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397903-399459:1:exon

YMR064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NCA1
gene: AEP1
locus tag: YMR064W
gene synonym: NCA1
product: Aep1p
transcript id: NM_001182562.1
SIO_010081: YMR064W
subclass of: SO_0000673
so part of: YMR064W
location: <397903..>399459
location: region:397903-399459:1
so has part: feature:397903-399459:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397903-399459:1:exon

YMR064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NCA1
gene: AEP1
locus tag: YMR064W
gene synonym: NCA1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:21454598]
experiment: EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:21454598]
note: Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase
codon start: 1
product: Aep1p
translation: MITTVQEISKWRNLCFIRMQSRKWYPVLKKTPLVADGRKIIKHADKVPHPEEIIHPFYQPTAIEQFTACATEYNPSLLDGKKIAPSLIKHPVSLKTILVDSKLKFDDIRGVNKWLMEFVARRQHQRNIVLTPASKSVRSFHVLHLSSTDIAKLRGLENILSEIENTNDLQSRVESVNNELQNIFDRDSKQTRLFCENILAYLIKNYGNSTEKLILLINVTEMQLYSRLDQMKAMNIILYNILCKVEANENPPYSPTLVTALENLLAAINNRFFPGRCENSLHPIVIEQLLSYFIKTGNLNESKNFLGHLIKKGILPEATIINRYLEAIDVHFDKSTKIFDIRSKFAFIADLAPIIENYGTIDLFKFLIPMCRHFDELCSLLNIIRKSNNAKRAVDSTLPIFIKKVLTFTKDPMINSGNLSTVFNIVSPIYGQNVPSEFVEKFILSFALQGNYTMMAHMIDTYKIKLSHKYQLQIIRALKNSERNHALKNTGAVGYNKEFKKYFIEKYLNCTEREALRP
SIO_010081: YMR064W
subclass of: SO_0000673
so part of: YMR064W
location: 397903..399459
location: region:397903-399459:1
so has part: feature:397903-399459:1:exon

NP_013780.1
type: Protein
SIO_000068: ncbiprotein

S000004668
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397903-399459:1:exon

YMR065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FIG3
gene: KAR5
locus tag: YMR065W
gene synonym: FIG3
so part of: sequence
location: <399702..>401216
location: region:399702-401216:1
so has part: feature:399702-401216:1:exon
subclass of: SO_0000010

855087
type: Gene
SIO_000068: ncbigene

position:399702:1
position: 399702
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:401216:1
position: 401216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:399702-401216:1:exon

YMR065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FIG3
gene: KAR5
locus tag: YMR065W
gene synonym: FIG3
product: Kar5p
transcript id: NM_001182563.1
SIO_010081: YMR065W
subclass of: SO_0000673
so part of: YMR065W
location: <399702..>401216
location: region:399702-401216:1
so has part: feature:399702-401216:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:399702-401216:1:exon

YMR065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FIG3
gene: KAR5
locus tag: YMR065W
gene synonym: FIG3
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9382856]
experiment: EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]
note: Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone
codon start: 1
product: Kar5p
translation: MFEMRYVYLFAICIKFVSSSELGKINNLLQGRLIYTDNSVATNVLESKFPFLKSTCVKDALKLFLPQCIANGLESIDAETRVETAIKLSICEFQASGLGEIPENCMVDDLGSMMDCMFELESSSQWWTTYSGNYQRLSSICYENLLPFEKEQILKLFLNITELYDSFGDDVDTKLNHLMFQMEQDSQNFLDDLARMFRNYDNELRNATESNRIILENDLSFFRNKVNDVLYETSEQLEVQIIEKNSQLMNEVDTVHHIMSDLADELAKNDIKSKINDLKDDSLNNLQDLVEMSNDVKEYYSRNNKLVNTELENFSMGLKKQLGGMSKDLSESQMEAIELLQGFNSILHDSLLPSMTDEIVPEMTNFKNTLLQEWTAITSTLNGDFALWNEEIFSTFNDISEKLNGTKKKLDDIEIRVSLVHKNVMTMMRVLDFMWKTSKMIIRCGYLAVKNKYYWLLCSVVWIWSKYRTSRVNVKMIPIKRYYQWAALLLSIYLGAKTGSLIDF
SIO_010081: YMR065W
subclass of: SO_0000673
so part of: YMR065W
location: 399702..401216
location: region:399702-401216:1
so has part: feature:399702-401216:1:exon

NP_013781.1
type: Protein
SIO_000068: ncbiprotein

S000004669
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:399702-401216:1:exon

YMR066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOV1
locus tag: YMR066W
so part of: sequence
location: <401541..>404237
location: region:401541-404237:1
so has part: feature:401541-404237:1:exon
subclass of: SO_0000010

855088
type: Gene
SIO_000068: ncbigene

position:401541:1
position: 401541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:404237:1
position: 404237
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401541-404237:1:exon

YMR066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOV1
locus tag: YMR066W
product: Sov1p
transcript id: NM_001182564.1
SIO_010081: YMR066W
subclass of: SO_0000673
so part of: YMR066W
location: <401541..>404237
location: region:401541-404237:1
so has part: feature:401541-404237:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:401541-404237:1:exon

YMR066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOV1
locus tag: YMR066W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0008494 translation activator activity [PMID:32449921]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:32449921]
experiment: EXISTENCE:mutant phenotype:GO:0061668 mitochondrial ribosome assembly [PMID:32449921]
note: Mitochondrial hypothetical protein
codon start: 1
product: Sov1p
translation: MFKYNRSLCSSALIAKSQIRFYRLKRAPLNYASHIPEVLNKTIIGPDEPEKCLILKGKTSEEIENNLLSNKKFQEINPLDTIQETFIQYLKFCNETNFKRSNKNLNRLKKTLESKDSNSTVKINAVFNYLLEECDLEIKRLNTTGQTQVYNEEKGNEDDLEQSIMNDIFRSAQEQFEDQEGHIPLRSTSFLLEILKSFNERFNGIIKPKESITEMVTFSQLAQAFEVVKLIPVQEMKEKGIYLVGNLLYGTGKVRLDPINESFYIESLLVFGNYKAAYSLFITNKDKVNERWWNELGLMITLRSNHLRNFRKLLAETDAKYSTKYSYLSPRVTKLSIRKYLSIGNVTEANILTDRFIKLVEEVGIIRMKDEQEELPTGVKNFQNEKHATEFLNELEIPSDHDYISIVDFHLYKRNIPMAAQLISKYMEIPGTTQEDAAFLLVKTKLNMLKDFEKLRNIFAQNKDYVVPENNVKMLQEAFESVITKYNTNSPIYNELLFENVSALTKSIVLTDFLEEFITKQASGQWMELNSVSRSRKFNGLLNILLGTGEEEKAYNILKKLEEASKKSKTDPDLLYNQFYSEVNAYHYAKFVEFYSLQIQNMKAQNTPSFRKKEFKQKVKSLLKRMQESEVIPNAVFLREILNFYDSMYDFNSSFEIINPLLESKQQVSSESSLSTSNPCRFYNRRIITKPLYHKIWSVYCHYYHVLQNNSRILSKKSSIVKKLIKRQIKIHPTCHPRVLFQMTAENGEILPDKTFSKLIVSTFMKSGDLEAIPAILTFLTKKFDLNIDYDLSMYILKGLKRQYLRDISNISKDACEYKLRKAELMNNESILKNIPQGTNQENTISHLIREILIFIKWKEKSDCSTFLMVEDAFKELGTEFTLLEELIEDVNKLKIKA
SIO_010081: YMR066W
subclass of: SO_0000673
so part of: YMR066W
location: 401541..404237
location: region:401541-404237:1
so has part: feature:401541-404237:1:exon

NP_013782.1
type: Protein
SIO_000068: ncbiprotein

S000004670
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401541-404237:1:exon

YMR067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CUI1
gene: UBX4
locus tag: YMR067C
gene synonym: CUI1
so part of: sequence
location: complement(<404323..>405573)
location: region:404323-405573:-1
so has part: feature:404323-405573:-1:exon
subclass of: SO_0000010

855089
type: Gene
SIO_000068: ncbigene

position:404323:-1
position: 404323
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:405573:-1
position: 405573
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:404323-405573:-1:exon

YMR067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CUI1
gene: UBX4
locus tag: YMR067C
gene synonym: CUI1
product: Ubx4p
transcript id: NM_001182565.1
SIO_010081: YMR067C
subclass of: SO_0000673
so part of: YMR067C
location: complement(<404323..>405573)
location: region:404323-405573:-1
so has part: feature:404323-405573:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:404323-405573:-1:exon

YMR067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CUI1
gene: UBX4
locus tag: YMR067C
gene synonym: CUI1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14755638|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19359248]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:21148305]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:19359248]
experiment: EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:14755638]
note: UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant
codon start: 1
product: Ubx4p
translation: MPMVTVKYNFQLFKCKVSLNSTLNDVLHQSIQFFQLHTSSNDWSLIHLDKPVPLDLPWRLLNLPTGVNLELSKSSNFPVANKTNREDIPFNTIKIRFQIPGRDSVVKEMPSDQPIAPILRQMSGAAGDDFKIQVFSKIIEFKTIKDENLTLENLGIQEPSSVRLIFNNTSHSEGISANSAIHPKQTPPTMTNPETVASLPPHELHKPSVFLPSDEPLAVIKDQIEDEEDYELTVEQAKKYQKMLSSKAGTLGGPILTKRLREQSANNLPKKNKAISECLLRVKFPDRSHIQIAFKPNEDMRTVYNVVSQFLIDENMPFTLNQSHPFKPLAKDDKKLLDDLEFGSKTMLLFETNSNSNGPLIKAHLLEDAQKITHETRTTPSVNTINKSNPQGPSDNATSIKKTLNRVPKWMKLSKK
SIO_010081: YMR067C
subclass of: SO_0000673
so part of: YMR067C
location: complement(404323..405573)
location: region:404323-405573:-1
so has part: feature:404323-405573:-1:exon

NP_013783.1
type: Protein
SIO_000068: ncbiprotein

S000004671
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:404323-405573:-1:exon

YMR068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVO2
locus tag: YMR068W
so part of: sequence
location: <406304..>407584
location: region:406304-407584:1
so has part: feature:406304-407584:1:exon
subclass of: SO_0000010

855090
type: Gene
SIO_000068: ncbigene

position:406304:1
position: 406304
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:407584:1
position: 407584
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:406304-407584:1:exon

YMR068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVO2
locus tag: YMR068W
product: Avo2p
transcript id: NM_001182566.1
SIO_010081: YMR068W
subclass of: SO_0000673
so part of: YMR068W
location: <406304..>407584
location: region:406304-407584:1
so has part: feature:406304-407584:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:406304-407584:1:exon

YMR068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVO2
locus tag: YMR068W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30969890]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]
note: Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p
codon start: 1
product: Avo2p
translation: MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED
SIO_010081: YMR068W
subclass of: SO_0000673
so part of: YMR068W
location: 406304..407584
location: region:406304-407584:1
so has part: feature:406304-407584:1:exon

NP_013784.1
type: Protein
SIO_000068: ncbiprotein

S000004672
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:406304-407584:1:exon

YMR069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAA40
gene: NAT4
locus tag: YMR069W
gene synonym: NAA40
so part of: sequence
location: <407709..>408566
location: region:407709-408566:1
so has part: feature:407709-408566:1:exon
subclass of: SO_0000010

855091
type: Gene
SIO_000068: ncbigene

position:407709:1
position: 407709
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:408566:1
position: 408566
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407709-408566:1:exon

YMR069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAA40
gene: NAT4
locus tag: YMR069W
gene synonym: NAA40
product: N-terminal L-serine N(alpha)-acetyltransferase NatD
transcript id: NM_001182567.1
SIO_010081: YMR069W
subclass of: SO_0000673
so part of: YMR069W
location: <407709..>408566
location: region:407709-408566:1
so has part: feature:407709-408566:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407709-408566:1:exon

YMR069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAA40
gene: NAT4
locus tag: YMR069W
gene synonym: NAA40
EC number: 2.3.1.257
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010485 histone H4 acetyltransferase activity [PMID:12915400]
experiment: EXISTENCE:direct assay:GO:0043967 histone H4 acetylation [PMID:12915400]
experiment: EXISTENCE:mutant phenotype:GO:0010485 histone H4 acetyltransferase activity [PMID:12915400]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:24068969]
experiment: EXISTENCE:mutant phenotype:GO:0043967 histone H4 acetylation [PMID:12915400]
experiment: EXISTENCE:mutant phenotype:GO:0043968 histone H2A acetylation [PMID:12915400]
experiment: EXISTENCE:mutant phenotype:GO:0043998 histone H2A acetyltransferase activity [PMID:12915400]
note: N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A
codon start: 1
product: N-terminal L-serine N(alpha)-acetyltransferase NatD
translation: MRSSVYSENTYNCIRTSKEHLTERRRVAMAPMFQHFLNLCVEKFPESIEHKDTDGNGNFTTAILEREIIYIPEDDTDSIDSVDSLKCINYKLHKSRGDQVLDACVQLIDKHLGAKYRRASRIMYGNRKPWKANKLAEMKSAGLVYVCYWDNGVLGAFTSFMLTEETGLVEGDALHEVSVPVIYLYEVHVASAHRGHGIGRRLLEHALCDGVARHTRRMCDNFFGVALTVFSDNTRARRLYEALGFYRAPGSPAPASPTIRHTRHGGGRVVVPCDPLYYVYCLHMP
SIO_010081: YMR069W
subclass of: SO_0000673
so part of: YMR069W
location: 407709..408566
location: region:407709-408566:1
so has part: feature:407709-408566:1:exon

NP_013785.1
type: Protein
SIO_000068: ncbiprotein

S000004673
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407709-408566:1:exon

YMR070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ROX7
gene: MOT3
locus tag: YMR070W
gene synonym: ROX7
so part of: sequence
location: <409154..>410626
location: region:409154-410626:1
so has part: feature:409154-410626:1:exon
subclass of: SO_0000010

855092
type: Gene
SIO_000068: ncbigene

position:409154:1
position: 409154
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:410626:1
position: 410626
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:409154-410626:1:exon

YMR070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ROX7
gene: MOT3
locus tag: YMR070W
gene synonym: ROX7
product: Mot3p
transcript id: NM_001182568.1
SIO_010081: YMR070W
subclass of: SO_0000673
so part of: YMR070W
location: <409154..>410626
location: region:409154-410626:1
so has part: feature:409154-410626:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:409154-410626:1:exon

YMR070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ROX7
gene: MOT3
locus tag: YMR070W
gene synonym: ROX7
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9611199|PMID:10982825]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23435728]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9611199|PMID:22932476|PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12145211|PMID:10982825|PMID:21299653]
experiment: EXISTENCE:mutant phenotype:GO:0010895 negative regulation of ergosterol biosynthetic process [PMID:12145211|PMID:21299653]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11292809|PMID:23435728]
experiment: EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14665463]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:16783004]
note: Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions
codon start: 1
product: Mot3p
translation: MNADHHLQQQQQQRQQHQQQQHQQQQHQHQHQQQQHTILQNVSNTNNIGSDSLASQPFNTTTVSSNKDDVMVNSGARELPMPLHQQQYIYPYYQYTSNNSNNNNVTAGNNMSASPIVHNNSNNSNNSNISASDYTVANNSTSNNNNNNNNNNNNNNNIHPNQFTAAANMNSNAAAAAYYSFPTANMPIPQQDQQYMFNPASYISHYYSAVNSNNNGNNAANNGSNNSSHSAPAPAPGPPHHHHHHSNTHNNLNNGGAVNTNNAPQHHPTIITDQFQFQLQQNPSPNLNLNINPAQPLHLPPGWKINTMPQPRPTTAPNHPPAPVPSSNPVASNLVPAPSSDHKYIHQCQFCEKSFKRKSWLKRHLLSHSQQRHFLCPWCLSRQKRKDNLLQHMKLKHTNYLLDELKKNNIIFNYNNSSSSNNNNDNNNNNNSNSASGSGGAGAAAAAATAPENEDGNGYDTNIKTLINDGVLNKDDVKRVLNNLIVSHNK
SIO_010081: YMR070W
subclass of: SO_0000673
so part of: YMR070W
location: 409154..410626
location: region:409154-410626:1
so has part: feature:409154-410626:1:exon

NP_013786.1
type: Protein
SIO_000068: ncbiprotein

S000004674
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:409154-410626:1:exon

YMR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TVP18
locus tag: YMR071C
so part of: sequence
location: complement(<410762..>411265)
location: region:410762-411265:-1
so has part: feature:410762-411265:-1:exon
subclass of: SO_0000010

855093
type: Gene
SIO_000068: ncbigene

position:410762:-1
position: 410762
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:411265:-1
position: 411265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410762-411265:-1:exon

YMR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TVP18
locus tag: YMR071C
product: Tvp18p
transcript id: NM_001182569.1
SIO_010081: YMR071C
subclass of: SO_0000673
so part of: YMR071C
location: complement(<410762..>411265)
location: region:410762-411265:-1
so has part: feature:410762-411265:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410762-411265:-1:exon

YMR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TVP18
locus tag: YMR071C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]
note: Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport
codon start: 1
product: Tvp18p
translation: MALSLGQFINVGGMVKDLKSFNFSVYGRWFGYINIILCIALGIANLFHVSGVIAFGIISIIQGLVILFIEIPFLLKICPLSDNFIEFIKRFETNGWRCLFYLAMAIIQYISIAVMATSLIVVAVGLTISSISYAVAYTKHQEFQNTNIIKNPTDDDFPHEAVVREML
SIO_010081: YMR071C
subclass of: SO_0000673
so part of: YMR071C
location: complement(410762..411265)
location: region:410762-411265:-1
so has part: feature:410762-411265:-1:exon

NP_013787.1
type: Protein
SIO_000068: ncbiprotein

S000004675
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410762-411265:-1:exon

YMR072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ABF2
locus tag: YMR072W
so part of: sequence
location: <411569..>412120
location: region:411569-412120:1
so has part: feature:411569-412120:1:exon
subclass of: SO_0000010

855094
type: Gene
SIO_000068: ncbigene

position:411569:1
position: 411569
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412120:1
position: 412120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411569-412120:1:exon

YMR072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ABF2
locus tag: YMR072W
product: DNA-binding protein ABF2
transcript id: NM_001182570.1
SIO_010081: YMR072W
subclass of: SO_0000673
so part of: YMR072W
location: <411569..>412120
location: region:411569-412120:1
so has part: feature:411569-412120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:411569-412120:1:exon

YMR072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ABF2
locus tag: YMR072W
experiment: EXISTENCE:direct assay:GO:0000262 mitochondrial chromosome [PMID:9581629]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:27449618|PMID:9581629]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:1737790]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431|PMID:27371858]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9581629]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9581629]
experiment: EXISTENCE:mutant phenotype:GO:0090139 mitochondrial chromosome packaging [PMID:21282901]
note: Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication; human homolog TFAM can complement yeast abf2 mutant, rescuing the loss-of-mitochondrial DNA phenotype
codon start: 1
product: DNA-binding protein ABF2
translation: MNSYSLLTRSFHESSKPLFNLASTLLKASKRTQLRNELIKQGPKRPTSAYFLYLQDHRSQFVKENPTLRPAEISKIAGEKWQNLEADIKEKYISERKKLYSEYQKAKKEFDEKLPPKKPAGPFIKYANEVRSQVFAQHPDKSQLDLMKIIGDKWQSLDQSIKDKYIQEYKKAIQEYNARYPLN
SIO_010081: YMR072W
subclass of: SO_0000673
so part of: YMR072W
location: 411569..412120
location: region:411569-412120:1
so has part: feature:411569-412120:1:exon

NP_013788.1
type: Protein
SIO_000068: ncbiprotein

S000004676
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411569-412120:1:exon

YMR073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRC21
locus tag: YMR073C
so part of: sequence
location: complement(<412268..>412873)
location: region:412268-412873:-1
so has part: feature:412268-412873:-1:exon
subclass of: SO_0000010

855095
type: Gene
SIO_000068: ncbigene

position:412268:-1
position: 412268
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412873:-1
position: 412873
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412268-412873:-1:exon

YMR073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRC21
locus tag: YMR073C
product: Irc21p
transcript id: NM_001182571.1
SIO_010081: YMR073C
subclass of: SO_0000673
so part of: YMR073C
location: complement(<412268..>412873)
location: region:412268-412873:-1
so has part: feature:412268-412873:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:412268-412873:-1:exon

YMR073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRC21
locus tag: YMR073C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:23273983]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:16121259]
note: hypothetical protein; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
codon start: 1
product: Irc21p
translation: MSSDGMNRDVSNSKPNVRFAAPQRLSVAHPAISSPLHMPMSKSSRKPLVRTKIRLDPGHSALDWHSLTSNPANYYTKFVSLQLIQDLLDDPVFQKDNFKFSPSQLKNQLLVQKIPLYKIMPPLRINRKIVKKHCKGEDELWCVINGKVYDISSYLKFHPGGTDILIKHRNSDDLITYFNKYHQWVNYEKLLQVCFIGVVCE
SIO_010081: YMR073C
subclass of: SO_0000673
so part of: YMR073C
location: complement(412268..412873)
location: region:412268-412873:-1
so has part: feature:412268-412873:-1:exon

NP_013789.1
type: Protein
SIO_000068: ncbiprotein

S000004677
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:412268-412873:-1:exon

YMR074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDD2
locus tag: YMR074C
so part of: sequence
location: complement(<413036..>413473)
location: region:413036-413473:-1
so has part: feature:413036-413473:-1:exon
subclass of: SO_0000010

855096
type: Gene
SIO_000068: ncbigene

position:413036:-1
position: 413036
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:413473:-1
position: 413473
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413036-413473:-1:exon

YMR074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDD2
locus tag: YMR074C
product: Sdd2p
transcript id: NM_001182572.1
SIO_010081: YMR074C
subclass of: SO_0000673
so part of: YMR074C
location: complement(<413036..>413473)
location: region:413036-413473:-1
so has part: feature:413036-413473:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413036-413473:-1:exon

YMR074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDD2
locus tag: YMR074C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:19469552]
note: Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
codon start: 1
product: Sdd2p
translation: MDPELQAIREARLAQLKNNSGGTNGDRNSGANNGGGENSAPVGAAIANFLEPQALERLSRVALVRRDRAQAVETYLKKLIATNNVTHKITEAEIVSILNGIAKQQNSQNNSKIIFERKDFSEDLNSFDKQNAKNDDDEDDDDFFD
SIO_010081: YMR074C
subclass of: SO_0000673
so part of: YMR074C
location: complement(413036..413473)
location: region:413036-413473:-1
so has part: feature:413036-413473:-1:exon

NP_013790.1
type: Protein
SIO_000068: ncbiprotein

S000004678
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413036-413473:-1:exon

YMR075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCO1
locus tag: YMR075W
so part of: sequence
location: <413982..>416036
location: region:413982-416036:1
so has part: feature:413982-416036:1:exon
subclass of: SO_0000010

855097
type: Gene
SIO_000068: ncbigene

position:413982:1
position: 413982
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416036:1
position: 416036
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413982-416036:1:exon

YMR075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCO1
locus tag: YMR075W
product: Rco1p
transcript id: NM_001182574.1
SIO_010081: YMR075W
subclass of: SO_0000673
so part of: YMR075W
location: <413982..>416036
location: region:413982-416036:1
so has part: feature:413982-416036:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413982-416036:1:exon

YMR075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCO1
locus tag: YMR075W
experiment: EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:16286008]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032221 Rpd3S/Clr6-CII complex [PMID:16286007|PMID:16286008]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:19948887]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24358376]
experiment: EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]
note: Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p
codon start: 1
product: Rco1p
translation: MDTSKKDTTRSPSHSNSSSPSSSSLSSSSSKEKKRPKRLSSQNVNYDLKRRKIITSEGIERSFKNEHSNLAVEDNIPEEEPKELLEKDSKGNIIKLNEPSTISEDSKVSVTGLPLNKGPSEKIKRESLWNYRKNLGGQSNNSEMTLVPSKRFTQVPKNFQDLNRNDLKTFLTENMTEESNIRSTIGWNGDIINRTRDREPESDRDNKKLSNIRTKIILSTNATYDSKSKLFGQNSIKSTSNASEKIFRDKNNSTIDFENEDFCSACNQSGSFLCCDTCPKSFHFLCLDPPIDPNNLPKGDWHCNECKFKIFINNSMATLKKIESNFIKQNNNVKIFAKLLFNIDSHNPKQFQLPNYIKETFPAVKTGSRGQYSDENDKIPLTDRQLFNTSYGQSITKLDSYNPDTHIDSNSGKFLICYKCNQTRLGSWSHPENSRLIMTCDYCQTPWHLDCVPRASFKNLGSKWKCPLHSPTKVYKKIHHCQEDNSVNYKVWKKQRLINKKNQLYYEPLQKIGYQNNGNIQIIPTTSHTDYDFNQDFKITQIDENSIKYDFFDKIYKSKMVQKRKLFQFQESLIDKLVSNGSQNGNSEDNMVKDIASLIYFQVSNNDKSSNNKSASKSNNLRKLWDLKELTNVVVPNELDSIQFNDFSSDEIKHLLYLKKIIESKPKEELLKFLNIENPENQSE
SIO_010081: YMR075W
subclass of: SO_0000673
so part of: YMR075W
location: 413982..416036
location: region:413982-416036:1
so has part: feature:413982-416036:1:exon

NP_013791.1
type: Protein
SIO_000068: ncbiprotein

S000004680
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413982-416036:1:exon

YMR075C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR075C-A
so part of: sequence
location: complement(<415688..>416053)
location: region:415688-416053:-1
so has part: feature:415688-416053:-1:exon
subclass of: SO_0000010

855098
type: Gene
SIO_000068: ncbigene

position:415688:-1
position: 415688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416053:-1
position: 416053
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:415688-416053:-1:exon

YMR075C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR075C-A
product: uncharacterized protein
transcript id: NM_001395040.1
SIO_010081: YMR075C-A
subclass of: SO_0000673
so part of: YMR075C-A
location: complement(<415688..>416053)
location: region:415688-416053:-1
so has part: feature:415688-416053:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:415688-416053:-1:exon

YMR075C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR075C-A
note: hypothetical protein; almost completely overlaps verified ORF RCO1/YMR075W
codon start: 1
product: uncharacterized protein
translation: MYVRRFYSDWFSGFSMFKNFNSSSFGLDSIIFFKYNRCFISSLEKSLNCIESSSFGTTTLVSSFKSHNFLKLLLLEADLLLLLLSLLLTWKYIKEAMSLTILSSLLPFWDPFDTNLSIKLS
SIO_010081: YMR075C-A
subclass of: SO_0000673
so part of: YMR075C-A
location: complement(415688..416053)
location: region:415688-416053:-1
so has part: feature:415688-416053:-1:exon

NP_001381970.1
type: Protein
SIO_000068: ncbiprotein

S000004679
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:415688-416053:-1:exon

YMR076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDS5
locus tag: YMR076C
so part of: sequence
location: complement(<416196..>420029)
location: region:416196-420029:-1
so has part: feature:416196-420029:-1:exon
subclass of: SO_0000010

855099
type: Gene
SIO_000068: ncbigene

position:416196:-1
position: 416196
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420029:-1
position: 420029
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:416196-420029:-1:exon

YMR076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDS5
locus tag: YMR076C
product: Pds5p
transcript id: NM_001182575.1
SIO_010081: YMR076C
subclass of: SO_0000673
so part of: YMR076C
location: complement(<416196..>420029)
location: region:416196-420029:-1
so has part: feature:416196-420029:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:416196-420029:-1:exon

YMR076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDS5
locus tag: YMR076C
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11062262]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0035808 meiotic recombination initiation complex [PMID:31617566]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:11137006]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778|PMID:19736318]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11062262|PMID:14623866]
experiment: EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:11062262]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:19736318]
experiment: EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:35102525]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:15819623]
experiment: EXISTENCE:mutant phenotype:GO:0140588 chromatin looping [PMID:32032532]
note: Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats
codon start: 1
product: Pds5p
translation: MAKGAVTKLKFNSPIISTSDQLISTNELLDRLKALHEELASLDQDNTDLTGLDKYRDALVSRKLLKHKDVGIRAFTACCLSDILRLYAPDAPYTDAQLTDIFKLVLSQFEQLGDQENGYHIQQTYLITKLLEYRSIVLLADLPSSNNLLIELFHIFYDPNKSFPARLFNVIGGILGEVISEFDSVPLEVLRLIFNKFLTYNPNEIPEGLNVTSDCGYEVSLILCDTYSNRMSRHLTKYYSEIIHEATNDDNNSRLLTVVVKLHKLVLRLWETVPELINAVIGFIYHELSSENELFRKEATKLIGQILTSYSDLNFVSTHSDTFKAWISKIADISPDVRVEWTESIPQIIATREDISKELNQALAKTFIDSDPRVRRTSVMIFNKVPVTEIWKNITNKAIYTSLLHLAREKHKEVRELCINTMAKFYSNSLNEIERTYQNKEIWEIIDTIPSTLYNLYYINDLNINEQVDSVIFEYLLPFEPDNDKRVHRLLTVLSHFDKKAFTSFFAFNARQIKISFAISKYIDFSKFLNNQESMSSSQGPIVMNKYNQTLQWLASGLSDSTKAIDALETIKQFNDERIFYLLNACVTNDIPFLTFKNCYNELVSKLQTPGLFKKYNISTGASIMPRDIAKVIQILLFRASPIIYNVSNISVLLNLSNNSDAKQLDLKRRILDDISKVNPTLFKDQIRTLKTIIKDLDDPDAEKNDNLSLEEALKTLYKASKTLKDQVDFDDTFFFTKLYDFAVESKPEITKYATKLIALSPKAEETLKKIKIRILPLDLQKDKYFTSHIIVLMEIFKKFPHVLNDDSTDIISYLIKEVLLSNQVVGDSKKEIDWVEDSLLSDTKYSAIGNKVFTLKLFTNKLRSIAPDVPRDELAESFTEKTMKLFFYLIASGGELISEFNKEFYPTPSNYQTKLRCVAGIQVLKLARISNLNNFIKPSDIIKLINLVEDESLPVRKTFLEQLKDYVANELISIKFLPLVFFTAYEPDVELKTTTKIWINFTFGLKSFKKGTIFERALPRLIHAIAHHPDIVGGLDSEGDAYLNALTTAIDYLLFYFDSIAAQENFSLLYYLSERVKNYQDKLVEDEIDEEEGPQKEEAPKKHRPYGQKMYIIGELSQMILLNLKEKKNWQHSAYPGKLNLPSDLFKPFATVQEAQLSFKTYIPESLTEKIQNNIKAKIGRILHTSQTQRQRLQKRLLAHENNESQKKKKKVHHARSQADDEEGDGDRESDSDDDSYSPSNKNETKKGHENIVMKKLRVRKEVDYKDDEDDDIEMT
SIO_010081: YMR076C
subclass of: SO_0000673
so part of: YMR076C
location: complement(416196..420029)
location: region:416196-420029:-1
so has part: feature:416196-420029:-1:exon

NP_013793.1
type: Protein
SIO_000068: ncbiprotein

S000004681
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:416196-420029:-1:exon

YNCM0023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0023C
so part of: sequence
location: complement(420588..420661)
location: region:420588-420661:-1
so has part: feature:420588-420661:-1:exon
subclass of: SO_0000663

855100
type: Gene
SIO_000068: ncbigene

position:420588:-1
position: 420588
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:420661:-1
position: 420661
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:420588-420661:-1:exon

YNCM0023C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0023C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0023C
subclass of: SO_0000673
so part of: YNCM0023C
location: complement(420588..420661)
location: region:420588-420661:-1
so has part: feature:420588-420661:-1:exon

S000006764
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:420588-420661:-1:exon

YMR077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHM6
alternative label: VPL10
alternative label: VPT20
gene: VPS20
locus tag: YMR077C
gene synonym: CHM6; VPL10; VPT20
so part of: sequence
location: complement(<421484..>422149)
location: region:421484-422149:-1
so has part: feature:421484-422149:-1:exon
subclass of: SO_0000010

855101
type: Gene
SIO_000068: ncbigene

position:421484:-1
position: 421484
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:422149:-1
position: 422149
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:421484-422149:-1:exon

YMR077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHM6
alternative label: VPL10
alternative label: VPT20
gene: VPS20
locus tag: YMR077C
gene synonym: CHM6; VPL10; VPT20
product: ESCRT-III subunit protein VPS20
transcript id: NM_001182576.1
SIO_010081: YMR077C
subclass of: SO_0000673
so part of: YMR077C
location: complement(<421484..>422149)
location: region:421484-422149:-1
so has part: feature:421484-422149:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:421484-422149:-1:exon

YMR077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHM6
alternative label: VPL10
alternative label: VPT20
gene: VPS20
locus tag: YMR077C
gene synonym: CHM6; VPL10; VPT20
experiment: EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31273031]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12953057]
experiment: EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15086794]
note: Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
codon start: 1
product: ESCRT-III subunit protein VPS20
translation: MGQKSSKVHITKTDRAILEVKRSKDEIHKFTRRTDNLILVEKSQLKDLIRKNPENYKSNMKVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQFINGLKNGNEILKKLNKEFSNVDELMDDVQDQIAYQNEINETLSRSLVGTSNYEDDLDKELDALESELNPEKMNNAKVANMPSTEGLPSLPQGEQTEQKEREEFATEERSDTKEPLALLS
SIO_010081: YMR077C
subclass of: SO_0000673
so part of: YMR077C
location: complement(421484..422149)
location: region:421484-422149:-1
so has part: feature:421484-422149:-1:exon

NP_013794.1
type: Protein
SIO_000068: ncbiprotein

S000004682
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:421484-422149:-1:exon

YMR078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHL12
gene: CTF18
locus tag: YMR078C
gene synonym: CHL12
so part of: sequence
location: complement(<422503..>424728)
location: region:422503-424728:-1
so has part: feature:422503-424728:-1:exon
subclass of: SO_0000010

855102
type: Gene
SIO_000068: ncbigene

position:422503:-1
position: 422503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:424728:-1
position: 424728
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:422503-424728:-1:exon

YMR078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHL12
gene: CTF18
locus tag: YMR078C
gene synonym: CHL12
product: Ctf18p
transcript id: NM_001182577.1
SIO_010081: YMR078C
subclass of: SO_0000673
so part of: YMR078C
location: complement(<422503..>424728)
location: region:422503-424728:-1
so has part: feature:422503-424728:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:422503-424728:-1:exon

YMR078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHL12
gene: CTF18
locus tag: YMR078C
gene synonym: CHL12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16962805]
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413]
experiment: EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17636314]
experiment: EXISTENCE:mutant phenotype:GO:0003689 DNA clamp loader activity [PMID:32277910]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11287619|PMID:11389843]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16525505]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:21347277]
experiment: EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]
note: Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
codon start: 1
product: Ctf18p
translation: MVDTAPYIGSLGRSSLFDTGDIEQAPGNNAIGINEEDIHAFVSSTGETVQLKKKPAKLATGNISLYTNPDTVWRSDDTYGININYLLDKIEASGDDRTNAQKTSPITGKIGSDTLWVEKWRPKKFLDLVGNEKTNRRMLGWLRQWTPAVFKEQLPKLPTEKEVSDMELDPLKRPPKKILLLHGPPGIGKTSVAHVIAKQSGFSVSEINASDERAGPMVKEKIYNLLFNHTFDTNPVCLVADEIDGSIESGFIRILVDIMQSDIKATNKLLYGQPDKKDKKRKKKRSKLLTRPIICICNNLYAPSLEKLKPFCEIIAVKRPSDTTLLERLNLICHKENMNIPIKAINDLIDLAQGDVRNCINNLQFLASNVDSRDSSASDKPACAKNTWASSNKDSPISWFKIVNQLFRKDPHRDIKEQFYELLNQVELNGNSDRILQGCFNIFPYVKYSDNGIRKPANISDWLFFHDLMYQSMYAHNGELLRYSALVPLVFFQTFGDIANKDDIRMKNSEYEQRELKRANSDIVSLIMRHISVQSPLMASFTDRKSLIFEILPYLDSMISSDFNKIRNLKLKQAIMEELVQLLKSFQLNLIQNRSEGFDVRGGLTIDPPIDEVVLLNPKHINEVQHKRANNLSSLLAKIEENRAKKRHIDQVTEDRLQSQEMHSKKVKTGLNSSSSTIDFFKNQYGLLKQTQELEETQKTIGSDETNQADDCNQTVKIWVKYNEGFSNAVRKNVTWNNLWE
SIO_010081: YMR078C
subclass of: SO_0000673
so part of: YMR078C
location: complement(422503..424728)
location: region:422503-424728:-1
so has part: feature:422503-424728:-1:exon

NP_013795.1
type: Protein
SIO_000068: ncbiprotein

S000004683
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:422503-424728:-1:exon

YMR079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PIT1
gene: SEC14
locus tag: YMR079W
gene synonym: PIT1
so part of: sequence
location: <424989..>426059
location: region:424989-426059:1
so has part: feature:424989-426059:1:exon
subclass of: SO_0000010

855103
type: Gene
SIO_000068: ncbigene

position:424989:1
position: 424989
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426059:1
position: 426059
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424989-426059:1:exon

YMR079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PIT1
gene: SEC14
locus tag: YMR079W
gene synonym: PIT1
product: phosphatidylinositol/phosphatidylcholine transfer protein SEC14
transcript id: NM_001182578.1
SIO_010081: YMR079W
subclass of: SO_0000673
so part of: YMR079W
location: join(<424989..424997,425154..>426059)
location: region:424989-426059:1
so has part: feature:424989-424997:1:exon
so has part: feature:425154-426059:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:424989-424997:1:exon

position:424997:1
position: 424997
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:425154-426059:1:exon

position:425154:1
position: 425154
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PIT1
gene: SEC14
locus tag: YMR079W
gene synonym: PIT1
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:7816798]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1997207]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:1997207]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12869188|PMID:2466847|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008525 phosphatidylcholine transporter activity [PMID:10488334|PMID:10848624|PMID:2407740]
experiment: EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624|PMID:2407740|PMID:2215682]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624|PMID:2407740|PMID:2215682]
experiment: EXISTENCE:direct assay:GO:0048194 Golgi vesicle budding [PMID:9553090|PMID:9736710]
experiment: EXISTENCE:direct assay:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:7816798]
experiment: EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:18753406]
experiment: EXISTENCE:genetic interaction:GO:0046488 phosphatidylinositol metabolic process [PMID:10567405]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:18753406]
experiment: EXISTENCE:mutant phenotype:GO:0008525 phosphatidylcholine transporter activity [PMID:10488334]
experiment: EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624|PMID:2215682]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:2215682]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:14528019]
experiment: EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624|PMID:19129178|PMID:6754086]
experiment: EXISTENCE:mutant phenotype:GO:0046488 phosphatidylinositol metabolic process [PMID:10567405]
experiment: EXISTENCE:mutant phenotype:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]
experiment: EXISTENCE:mutant phenotype:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:7816798]
note: Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol/phosphatidylcholine transfer protein SEC14
translation: MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGGLYLSDIGPWRDPKYIGPEGEAPEAFSMK
SIO_010081: YMR079W
subclass of: SO_0000673
so part of: YMR079W
location: join(424989..424997,425154..426059)
location: region:424989-426059:1
so has part: feature:424989-424997:1:exon
so has part: feature:425154-426059:1:exon

NP_013796.1
type: Protein
SIO_000068: ncbiprotein

S000004684
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424989-424997:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:425154-426059:1:exon

YMR080C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IFS2
alternative label: MOF4
alternative label: SUP113
alternative label: SUT2
alternative label: UPF1
gene: NAM7
locus tag: YMR080C
gene synonym: IFS2; MOF4; SUP113; SUT2; UPF1
so part of: sequence
location: complement(<426712..>429627)
location: region:426712-429627:-1
so has part: feature:426712-429627:-1:exon
subclass of: SO_0000010

855104
type: Gene
SIO_000068: ncbigene

position:426712:-1
position: 426712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:429627:-1
position: 429627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:426712-429627:-1:exon

YMR080C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IFS2
alternative label: MOF4
alternative label: SUP113
alternative label: SUT2
alternative label: UPF1
gene: NAM7
locus tag: YMR080C
gene synonym: IFS2; MOF4; SUP113; SUT2; UPF1
product: ATP-dependent RNA helicase NAM7
transcript id: NM_001182579.1
SIO_010081: YMR080C
subclass of: SO_0000673
so part of: YMR080C
location: complement(<426712..>429627)
location: region:426712-429627:-1
so has part: feature:426712-429627:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:426712-429627:-1:exon

YMR080C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IFS2
alternative label: MOF4
alternative label: SUP113
alternative label: SUT2
alternative label: UPF1
gene: NAM7
locus tag: YMR080C
gene synonym: IFS2; MOF4; SUP113; SUT2; UPF1
EC number: 3.6.4.12
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:8816462]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:7545033]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:18676617]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8816461|PMID:8816462]
experiment: EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:23801788]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16157874]
experiment: EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12769863|PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:8816461|PMID:8816462]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:16285926]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:8816461]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:16777600]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:18676617]
experiment: EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]
experiment: EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18676617]
note: ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: ATP-dependent RNA helicase NAM7
translation: MVGSGSHTPYDISNSPSDVNVQPATQLNSTLVEDDDVDNQLFEEAQVTETGFRSPSASDNSCAYCGIDSAKCVIKCNSCKKWFCNTKNGTSSSHIVNHLVLSHHNVVSLHPDSDLGDTVLECYNCGRKNVFLLGFVSAKSEAVVVLLCRIPCAQTKNANWDTDQWQPLIEDRQLLSWVAEQPTEEEKLKARLITPSQISKLEAKWRSNKDATINDIDAPEEQEAIPPLLLRYQDAYEYQRSYGPLIKLEADYDKQLKESQALEHISVSWSLALNNRHLASFTLSTFESNELKVAIGDEMILWYSGMQHPDWEGRGYIVRLPNSFQDTFTLELKPSKTPPPTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFDVPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDTKFRTVLIDESTQASEPECLIPIVKGAKQVILVGDHQQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEISANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLDNLQLCTVQLVRPQPRKTERPMNAQFNVESEMGDFPKFQDFDAQSMVSFSGQIGDFGNAFVDNTELSSYINNEYWNFENFKSAFSQKQNRNEIDDRNLYQEEASHLNSNFARELQREEQKHELSKDFSNLGI
SIO_010081: YMR080C
subclass of: SO_0000673
so part of: YMR080C
location: complement(426712..429627)
location: region:426712-429627:-1
so has part: feature:426712-429627:-1:exon

NP_013797.1
type: Protein
SIO_000068: ncbiprotein

S000004685
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:426712-429627:-1:exon

YMR081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MBR3
gene: ISF1
locus tag: YMR081C
gene synonym: MBR3
so part of: sequence
location: complement(<430079..>431095)
location: region:430079-431095:-1
so has part: feature:430079-431095:-1:exon
subclass of: SO_0000010

855105
type: Gene
SIO_000068: ncbigene

position:430079:-1
position: 430079
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:431095:-1
position: 431095
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:430079-431095:-1:exon

YMR081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MBR3
gene: ISF1
locus tag: YMR081C
gene synonym: MBR3
product: Isf1p
transcript id: NM_001182580.1
SIO_010081: YMR081C
subclass of: SO_0000673
so part of: YMR081C
location: complement(<430079..>431095)
location: region:430079-431095:-1
so has part: feature:430079-431095:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:430079-431095:-1:exon

YMR081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MBR3
gene: ISF1
locus tag: YMR081C
gene synonym: MBR3
experiment: EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:8208248]
note: Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that arose from the whole genome duplication
codon start: 1
product: Isf1p
translation: MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKLASFSFQNSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPANSTNNSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYGIPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPSSYLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSSPLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESSPHTSNCLEERNPRRKSFIKLSLASSFSN
SIO_010081: YMR081C
subclass of: SO_0000673
so part of: YMR081C
location: complement(430079..431095)
location: region:430079-431095:-1
so has part: feature:430079-431095:-1:exon

NP_013798.1
type: Protein
SIO_000068: ncbiprotein

S000004686
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:430079-431095:-1:exon

YMR082C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR082C
so part of: sequence
location: complement(<431769..>432125)
location: region:431769-432125:-1
so has part: feature:431769-432125:-1:exon
subclass of: SO_0000010

855106
type: Gene
SIO_000068: ncbigene

position:431769:-1
position: 431769
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:432125:-1
position: 432125
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431769-432125:-1:exon

YMR082C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR082C
product: uncharacterized protein
transcript id: NM_001348865.1
SIO_010081: YMR082C
subclass of: SO_0000673
so part of: YMR082C
location: complement(<431769..>432125)
location: region:431769-432125:-1
so has part: feature:431769-432125:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:431769-432125:-1:exon

YMR082C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR082C
note: hypothetical protein; conserved among S. cerevisiae strains; YMR082C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MTIAEITIRQKFSYPFLFGNVLGHPWPRNVPRKEIKMLLFRTANNSFPGFLLIFTRKRRNLPKQRDNEIPRTRALETYLRVFSAARKQREADATASFWRLVTSASRSHYHMWPIKRII
SIO_010081: YMR082C
subclass of: SO_0000673
so part of: YMR082C
location: complement(431769..432125)
location: region:431769-432125:-1
so has part: feature:431769-432125:-1:exon

NP_001335805.1
type: Protein
SIO_000068: ncbiprotein

S000004687
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431769-432125:-1:exon

YMR083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADH3
locus tag: YMR083W
so part of: sequence
location: <434788..>435915
location: region:434788-435915:1
so has part: feature:434788-435915:1:exon
subclass of: SO_0000010

855107
type: Gene
SIO_000068: ncbigene

position:434788:1
position: 434788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:435915:1
position: 435915
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434788-435915:1:exon

YMR083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADH3
locus tag: YMR083W
product: alcohol dehydrogenase ADH3
transcript id: NM_001182582.1
SIO_010081: YMR083W
subclass of: SO_0000673
so part of: YMR083W
location: <434788..>435915
location: region:434788-435915:1
so has part: feature:434788-435915:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:434788-435915:1:exon

YMR083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADH3
locus tag: YMR083W
EC number: 1.1.1.1
experiment: EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3550419]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3550419]
experiment: EXISTENCE:direct assay:GO:0006116 NADH oxidation [PMID:3546317]
experiment: EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
note: Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
codon start: 1
product: alcohol dehydrogenase ADH3
translation: MLRTSTLFTRRVQPSLFSRNILRLQSTAAIPKTQKGVIFYENKGKLHYKDIPVPEPKPNEILINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVKLGSNVKGWKVGDLAGIKWLNGSCMTCEFCESGHESNCPDADLSGYTHDGSFQQFATADAIQAAKIQQGTDLAEVAPILCAGVTVYKALKEADLKAGDWVAISGAAGGLGSLAVQYATAMGYRVLGIDAGEEKEKLFKKLGGEVFIDFTKTKNMVSDIQEATKGGPHGVINVSVSEAAISLSTEYVRPCGTVVLVGLPANAYVKSEVFSHVVKSINIKGSYVGNRADTREALDFFSRGLIKSPIKIVGLSELPKVYDLMEKGKILGRYVVDTSK
SIO_010081: YMR083W
subclass of: SO_0000673
so part of: YMR083W
location: 434788..435915
location: region:434788-435915:1
so has part: feature:434788-435915:1:exon

NP_013800.1
type: Protein
SIO_000068: ncbiprotein

S000004688
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434788-435915:1:exon

YMR084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR084W
so part of: sequence
location: <436628..>437416
location: region:436628-437416:1
so has part: feature:436628-437416:1:exon
subclass of: SO_0000010

855108
type: Gene
SIO_000068: ncbigene

position:436628:1
position: 436628
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437416:1
position: 437416
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:436628-437416:1:exon

YMR084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR084W
product: putative glutamine--fructose-6-phosphate transaminase
transcript id: NM_001182583.1
SIO_010081: YMR084W
subclass of: SO_0000673
so part of: YMR084W
location: <436628..>437416
location: region:436628-437416:1
so has part: feature:436628-437416:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:436628-437416:1:exon

YMR084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR084W
EC number: 2.6.1.16
note: hypothetical protein; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
codon start: 1
product: putative glutamine--fructose-6-phosphate transaminase
translation: MCGIFGYCNFLIEKTRGEIIDTLIEGLQALEYKEYDSSGISIQGDELESLNIYKQTGKISSLKEEIDLYNLNKNLPFISHCGIAHTRRATHGGLRRANCHPHNSDPSNEFVVVHNGVITNFANLKALLMAKGYVFKSDTDTECIPKLYKHIYDTSIELGYNLDFHVLTNLVLKELEGSYGLLCTSSHFPDEVVAARKGSPLVIGVKGKTDMDVNFVEVEYLDQEEDYLKLNTQTKSSGNVLAAAPVKYNTCLRKSPPFVHNT
SIO_010081: YMR084W
subclass of: SO_0000673
so part of: YMR084W
location: 436628..437416
location: region:436628-437416:1
so has part: feature:436628-437416:1:exon

NP_013801.1
type: Protein
SIO_000068: ncbiprotein

S000004689
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:436628-437416:1:exon

YMR085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR085W
so part of: sequence
location: <437491..>438789
location: region:437491-438789:1
so has part: feature:437491-438789:1:exon
subclass of: SO_0000010

855109
type: Gene
SIO_000068: ncbigene

position:437491:1
position: 437491
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:438789:1
position: 438789
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437491-438789:1:exon

YMR085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR085W
product: uncharacterized protein
transcript id: NM_001182584.1
SIO_010081: YMR085W
subclass of: SO_0000673
so part of: YMR085W
location: <437491..>438789
location: region:437491-438789:1
so has part: feature:437491-438789:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437491-438789:1:exon

YMR085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR085W
note: hypothetical protein; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
codon start: 1
product: uncharacterized protein
translation: MEFYLSSDCASLARYVSKVVYLEDNDIAHIYDGELHIHCSKIGSEDFSFRTVQKLELELSKIKKGPYDNFMQKEIYEQCETTKNVMRGRVDAFTNRVVLGGLENWLTELRRAKRIIMIASKASFHSCLAARPIFEELMEVPVNVELALDFVDRNCCIFRNDVCIFVSRSGETTDTINALNYCIKKEAVTIGVVNCSGSSISRFTHCGVHTNTGPEKGIATTKSYTSQYIALVMIALWMSEDLVSKIERRKEIIQALTIVPSQIKEVLELEPLIIELCDKKLKQHDTFLLLGRGYQFASALEGASKMKEISYVHSESILTNELGHRVLAVASDNPPIIAFATKDAFSPKIASCIDQIIERKGNPIIICNKGHKIWEQDKQKGNVVTLEVPQTVDCLQGILNVIPLQLISYWLAIKKDIGVDLPRDSAMSAPDI
SIO_010081: YMR085W
subclass of: SO_0000673
so part of: YMR085W
location: 437491..438789
location: region:437491-438789:1
so has part: feature:437491-438789:1:exon

NP_013802.1
type: Protein
SIO_000068: ncbiprotein

S000004690
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437491-438789:1:exon

YMR086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEG1
locus tag: YMR086W
so part of: sequence
location: <439208..>442090
location: region:439208-442090:1
so has part: feature:439208-442090:1:exon
subclass of: SO_0000010

855110
type: Gene
SIO_000068: ncbigene

position:439208:1
position: 439208
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442090:1
position: 442090
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439208-442090:1:exon

YMR086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEG1
locus tag: YMR086W
product: Seg1p
transcript id: NM_001182586.1
SIO_010081: YMR086W
subclass of: SO_0000673
so part of: YMR086W
location: <439208..>442090
location: region:439208-442090:1
so has part: feature:439208-442090:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439208-442090:1:exon

YMR086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEG1
locus tag: YMR086W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19269952|PMID:22869600]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:22869600]
note: Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication
codon start: 1
product: Seg1p
translation: MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTYRSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPLTKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSAHSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPINSNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHENIELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKREGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSSPTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFDTVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKPEAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMTMSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPKRNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSILYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTDTAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSLFKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPSMTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK
SIO_010081: YMR086W
subclass of: SO_0000673
so part of: YMR086W
location: 439208..442090
location: region:439208-442090:1
so has part: feature:439208-442090:1:exon

NP_013803.1
type: Protein
SIO_000068: ncbiprotein

S000004692
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439208-442090:1:exon

YMR087W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDL32
locus tag: YMR087W
so part of: sequence
location: <442527..>443381
location: region:442527-443381:1
so has part: feature:442527-443381:1:exon
subclass of: SO_0000010

855112
type: Gene
SIO_000068: ncbigene

position:442527:1
position: 442527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:443381:1
position: 443381
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442527-443381:1:exon

YMR087W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDL32
locus tag: YMR087W
product: putative ADP-ribose 1''-phosphate phosphatase
transcript id: NM_001182587.1
SIO_010081: YMR087W
subclass of: SO_0000673
so part of: YMR087W
location: <442527..>443381
location: region:442527-443381:1
so has part: feature:442527-443381:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:442527-443381:1:exon

YMR087W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDL32
locus tag: YMR087W
EC number: 3.1.3.84
note: Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
codon start: 1
product: putative ADP-ribose 1''-phosphate phosphatase
translation: MTGSLNRHSLLNGVKKMRIILCDTNEVVTNLWQESIPHAYIQNDKYLCIHHGHLQSLMDSMRKGDAIHHGHSYAIVSPGNSYGYLGGGFDKALYNYFGGKPFETWFRNQLGGRYHTVGSATVVDLQRCLEEKTIECRDGIRYIIHVPTVVAPSAPIFNPQNPLKTGFEPVFNAMWNALMHSPKDIDGLIIPGLCTGYAGVPPIISCKSMAFALRLYMAGDHISKELKNVLIMYYLQYPFEPFFPESCKIECQKLGIDIEMLKSFNVEKDAIELLIPRRILTLDL
SIO_010081: YMR087W
subclass of: SO_0000673
so part of: YMR087W
location: 442527..443381
location: region:442527-443381:1
so has part: feature:442527-443381:1:exon

NP_013805.1
type: Protein
SIO_000068: ncbiprotein

S000004693
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:442527-443381:1:exon

YMR088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VBA1
locus tag: YMR088C
so part of: sequence
location: complement(<443414..>445102)
location: region:443414-445102:-1
so has part: feature:443414-445102:-1:exon
subclass of: SO_0000010

855113
type: Gene
SIO_000068: ncbigene

position:443414:-1
position: 443414
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:445102:-1
position: 445102
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443414-445102:-1:exon

YMR088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VBA1
locus tag: YMR088C
product: Vba1p
transcript id: NM_001182588.1
SIO_010081: YMR088C
subclass of: SO_0000673
so part of: YMR088C
location: complement(<443414..>445102)
location: region:443414-445102:-1
so has part: feature:443414-445102:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443414-445102:-1:exon

YMR088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VBA1
locus tag: YMR088C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15572352|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]
experiment: EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]
experiment: EXISTENCE:mutant phenotype:GO:0015802 basic amino acid transport [PMID:15572352]
note: Permease of basic amino acids in vacuolar membrane; targeted to vacuole via AP-3 pathway
codon start: 1
product: Vba1p
translation: MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTAQFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFGSLSLVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILPFELLTRSFCLSSAVTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLAHCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDYTIYDMLESITFRSNSIWWKLIYVFASVLVSFGYACLLVATLVSIVFTVEKSQQGTMTGVFYLWRSIGNVLGASLTLVSYENSLSSMLWNYMFKTKRDDEYHFTKKQYYSLINDSSYLRGPNFPTDIFVRILDVYKKAFLISYIPNIALAAVGIVLSLYLVKHTYKRSSSS
SIO_010081: YMR088C
subclass of: SO_0000673
so part of: YMR088C
location: complement(443414..445102)
location: region:443414-445102:-1
so has part: feature:443414-445102:-1:exon

NP_013806.1
type: Protein
SIO_000068: ncbiprotein

S000004694
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443414-445102:-1:exon

YMR089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RCA1
gene: YTA12
locus tag: YMR089C
gene synonym: RCA1
so part of: sequence
location: complement(<445609..>448086)
location: region:445609-448086:-1
so has part: feature:445609-448086:-1:exon
subclass of: SO_0000010

855114
type: Gene
SIO_000068: ncbigene

position:445609:-1
position: 445609
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:448086:-1
position: 448086
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:445609-448086:-1:exon

YMR089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RCA1
gene: YTA12
locus tag: YMR089C
gene synonym: RCA1
product: m-AAA protease subunit YTA12
transcript id: NM_001182589.1
SIO_010081: YMR089C
subclass of: SO_0000673
so part of: YMR089C
location: complement(<445609..>448086)
location: region:445609-448086:-1
so has part: feature:445609-448086:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:445609-448086:-1:exon

YMR089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RCA1
gene: YTA12
locus tag: YMR089C
gene synonym: RCA1
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:19748354]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7929327]
experiment: EXISTENCE:direct assay:GO:0005745 m-AAA complex [PMID:8681382]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:19748354]
experiment: EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:19019989]
experiment: EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:12417197]
experiment: EXISTENCE:mutant phenotype:GO:0008237 metallopeptidase activity [PMID:8681382]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:19748354]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:8681382]
note: Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation
codon start: 1
product: m-AAA protease subunit YTA12
translation: MLLLSWSRIATKVVRRPVRFRSYYGLTHIKSLHTQYRLLNRLQENKSGNKNEDNNEDAKLNKEIPTDEEVEAIRKQVEKYIEQTKNNTIPANWKEQKRKIDESIRRLEDAVLKQESNRIQEERKEKEEENGPSKAKSNRTKEQGYFEGNNSRNIPPPPPPPPPKPPLNDPSNPVSKNVNLFQIGLTFFLLSFLLDLLNSLEEQSEITWQDFREKLLAKGYVAKLIVVNKSMVKVMLNDNGKNQADNYGRNFYYFTIGSIDSFEHKLQKAQDELDIDKDFRIPVLYVQEGNWAKAMFQILPTVLMIAGIIWLTRRSAQAAGGSRGGIFGLSRSKAKKFNTETDVKIKFKDVAGCDEAKEEIMEFVSFLKEPSRYEKMGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYFVSGSEFVEMFVGVGAARVRDLFKTARENAPSIVFIDEIDAIGKARQKGNFSGANDERENTLNQMLVEMDGFTPADHVVVLAGTNRPDILDKALLRPGRFDRHINIDKPELEGRKAIFAVHLHHLKLAGEIFDLKNRLAALTPGFSGADIANVCNEAALIAARSDEDAVKLNHFEQAIERVIGGVERKSKLLSPEEKKVVAYHEAGHAVCGWYLKYADPLLKVSIIPRGQGALGYAQYLPGDIFLLTEQQLKDRMTMSLGGRVSEELHFPSVTSGASDDFKKVTSMATAMVTELGMSDKIGWVNYQKRDDSDLTKPFSDETGDIIDSEVYRIVQECHDRCTKLLKEKAEDVEKIAQVLLKKEVLTREDMIDLLGKRPFPERNDAFDKYLNDYETEKIRKEEEKNEKRNEPKPSTN
SIO_010081: YMR089C
subclass of: SO_0000673
so part of: YMR089C
location: complement(445609..448086)
location: region:445609-448086:-1
so has part: feature:445609-448086:-1:exon

NP_013807.1
type: Protein
SIO_000068: ncbiprotein

S000004695
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:445609-448086:-1:exon

YMR090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR090W
so part of: sequence
location: <449245..>449928
location: region:449245-449928:1
so has part: feature:449245-449928:1:exon
subclass of: SO_0000010

855115
type: Gene
SIO_000068: ncbigene

position:449245:1
position: 449245
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449928:1
position: 449928
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449245-449928:1:exon

YMR090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR090W
product: uncharacterized protein
transcript id: NM_001182590.1
SIO_010081: YMR090W
subclass of: SO_0000673
so part of: YMR090W
location: <449245..>449928
location: region:449245-449928:1
so has part: feature:449245-449928:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:449245-449928:1:exon

YMR090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR090W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
codon start: 1
product: uncharacterized protein
translation: MSPMKVAVVGASGKVGRLLINQLKANDSFSTPLAIVRTQDQVNYFKNEVGVDASLTDIENASVSEITDAIKAYDAVVFSAGAGGKGMERIFTVDLDGCIKVVEACEKAGIKRFVVVSALKAEDRDFWYNIKGLREYYIAKRSADREVRNSNLDYTILQPGSLELNKGTGLLQPLDKLEEKASVNYSINREDVASFIVESLLHPNATVKKTISLVNGNEPMEKFIQSL
SIO_010081: YMR090W
subclass of: SO_0000673
so part of: YMR090W
location: 449245..449928
location: region:449245-449928:1
so has part: feature:449245-449928:1:exon

NP_013808.1
type: Protein
SIO_000068: ncbiprotein

S000004696
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:449245-449928:1:exon

YMR091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RSC7
gene: NPL6
locus tag: YMR091C
gene synonym: RSC7
so part of: sequence
location: complement(<450058..>451365)
location: region:450058-451365:-1
so has part: feature:450058-451365:-1:exon
subclass of: SO_0000010

855116
type: Gene
SIO_000068: ncbigene

position:450058:-1
position: 450058
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451365:-1
position: 451365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450058-451365:-1:exon

YMR091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RSC7
gene: NPL6
locus tag: YMR091C
gene synonym: RSC7
product: Npl6p
transcript id: NM_001182591.1
SIO_010081: YMR091C
subclass of: SO_0000673
so part of: YMR091C
location: complement(<450058..>451365)
location: region:450058-451365:-1
so has part: feature:450058-451365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450058-451365:-1:exon

YMR091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RSC7
gene: NPL6
locus tag: YMR091C
gene synonym: RSC7
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366|PMID:14729968]
note: Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions
codon start: 1
product: Npl6p
translation: MSDSEGGLASEVEHEKRSRSTSNRPNYAIDTEDLDIDENDENEDDDYREEEANEGVNEEEISDEEEQINKSGRNKRRHVDEEEDLSEDKGVTRSRNRSKFKKPVFPGIDDAEENLNPLKVVNEEYVLPDDPEGETKITADGDLLGGREFLVRTFTLTEKGNRKFMLATEPARIVGFRDSYLFFQTHPNLYKFILNQTQKNDLIDRGVLPYSYRNRQIALVTARGVFKEFGAKIIRGGKHITDDYYASELRTKGNVIEGKLAGDPIDKSARALETMMYPASENGINPAKNQVEFFEHRPHGHMSNSNIIASGSKLSSTNWLYQHSAACSRFNSDLFYDRVKVLLVDQQGLRDAYTNILHIPESTQSTTVLGWRRSKNDSPSDTSIVYETVIHDNDLNKPKTGLSEIPKEIYEDVVDEDVLRAITEQQNFEKCNEYI
SIO_010081: YMR091C
subclass of: SO_0000673
so part of: YMR091C
location: complement(450058..451365)
location: region:450058-451365:-1
so has part: feature:450058-451365:-1:exon

NP_013809.1
type: Protein
SIO_000068: ncbiprotein

S000004697
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450058-451365:-1:exon

YMR092C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIP1
locus tag: YMR092C
so part of: sequence
location: complement(<451632..>453479)
location: region:451632-453479:-1
so has part: feature:451632-453479:-1:exon
subclass of: SO_0000010

855117
type: Gene
SIO_000068: ncbigene

position:451632:-1
position: 451632
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453479:-1
position: 453479
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451632-453479:-1:exon

YMR092C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIP1
locus tag: YMR092C
product: Aip1p
transcript id: NM_001182592.1
SIO_010081: YMR092C
subclass of: SO_0000673
so part of: YMR092C
location: complement(<451632..>453479)
location: region:451632-453479:-1
so has part: feature:451632-453479:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:451632-453479:-1:exon

YMR092C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIP1
locus tag: YMR092C
experiment: EXISTENCE:direct assay:GO:0003779 actin binding [PMID:10366597]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005884 actin filament [PMID:23333351]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10366597]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0030042 actin filament depolymerization [PMID:10366597]
experiment: EXISTENCE:genetic interaction:GO:0032466 negative regulation of cytokinesis [PMID:25371407]
experiment: EXISTENCE:mutant phenotype:GO:0051016 barbed-end actin filament capping [PMID:23333351]
experiment: EXISTENCE:physical interaction:GO:0030042 actin filament depolymerization [PMID:10366597]
note: Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; mutations in human homolog WDR1 are associated with cardiac hypertrophy
codon start: 1
product: Aip1p
translation: MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNVVLE
SIO_010081: YMR092C
subclass of: SO_0000673
so part of: YMR092C
location: complement(451632..453479)
location: region:451632-453479:-1
so has part: feature:451632-453479:-1:exon

NP_013810.1
type: Protein
SIO_000068: ncbiprotein

S000004698
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451632-453479:-1:exon

YMR093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP15
locus tag: YMR093W
so part of: sequence
location: <454015..>455556
location: region:454015-455556:1
so has part: feature:454015-455556:1:exon
subclass of: SO_0000010

855118
type: Gene
SIO_000068: ncbigene

position:454015:1
position: 454015
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:455556:1
position: 455556
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454015-455556:1:exon

YMR093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP15
locus tag: YMR093W
product: snoRNA-binding rRNA-processing protein UTP15
transcript id: NM_001182593.1
SIO_010081: YMR093W
subclass of: SO_0000673
so part of: YMR093W
location: <454015..>455556
location: region:454015-455556:1
so has part: feature:454015-455556:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454015-455556:1:exon

YMR093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP15
locus tag: YMR093W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]
experiment: EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]
note: Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
codon start: 1
product: snoRNA-binding rRNA-processing protein UTP15
translation: MSTARPRIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNINQFKWSEALDNAFVPGMAKELTLTVLQELRKRGKVRVALYGRDESTLEPLLNWCLKGIEDVRSASIVADWVAVVLELYGNTLESSPVLQELMIDLKTKVRHEIHKSKEAQRIEGMLQLLTS
SIO_010081: YMR093W
subclass of: SO_0000673
so part of: YMR093W
location: 454015..455556
location: region:454015-455556:1
so has part: feature:454015-455556:1:exon

NP_013811.1
type: Protein
SIO_000068: ncbiprotein

S000004699
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454015-455556:1:exon

YMR094W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTF13
locus tag: YMR094W
so part of: sequence
location: <455825..>457261
location: region:455825-457261:1
so has part: feature:455825-457261:1:exon
subclass of: SO_0000010

855119
type: Gene
SIO_000068: ncbigene

position:455825:1
position: 455825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457261:1
position: 457261
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455825-457261:1:exon

YMR094W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTF13
locus tag: YMR094W
product: Ctf13p
transcript id: NM_001182594.1
SIO_010081: YMR094W
subclass of: SO_0000673
so part of: YMR094W
location: <455825..>457261
location: region:455825-457261:1
so has part: feature:455825-457261:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:455825-457261:1:exon

YMR094W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTF13
locus tag: YMR094W
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10097110]
experiment: EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:1997204|PMID:8670864|PMID:8706132]
experiment: EXISTENCE:direct assay:GO:0051382 kinetochore assembly [PMID:12084919]
experiment: EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]
note: Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
codon start: 1
product: Ctf13p
translation: MPSFNPVRFLELPIDIRKEVYFHLDGNFCGAHPYPIDILYKSNDVELPGKPSYKRSKRSKKLLRYMYPVFATYLNIFEYSPQLIEKWLEYAFWLRYDCLVLDCFKVNHLYDGTLIDALEWTYLDNELRLAYFNKASMLEVWYTFKEYKKWVIDSVAFDELDLLNVSNIQFNIDNLTPQLVDKCLSILEQKDLFATIGEVQFGQDEEVGEEKDVDVSGANSDENSSPSSTIKNKKRSASKRSHSDNGNVGATHNQLTSISVIRTIRSMESMKSLRKITVRGEKLYELLINFHGFRDNPGKTISYIVKRRINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKSLTMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKELDKSEINQITYLRCQAIVWLSFRTLNHIKLQNVSEVFNNIIVPRALFDSKRVEIYRCEKISQVLVI
SIO_010081: YMR094W
subclass of: SO_0000673
so part of: YMR094W
location: 455825..457261
location: region:455825-457261:1
so has part: feature:455825-457261:1:exon

NP_013812.1
type: Protein
SIO_000068: ncbiprotein

S000004700
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455825-457261:1:exon

YMR095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNO1
locus tag: YMR095C
so part of: sequence
location: complement(<457285..>457959)
location: region:457285-457959:-1
so has part: feature:457285-457959:-1:exon
subclass of: SO_0000010

855120
type: Gene
SIO_000068: ncbigene

position:457285:-1
position: 457285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457959:-1
position: 457959
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:457285-457959:-1:exon

YMR095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNO1
locus tag: YMR095C
product: putative pyridoxal 5'-phosphate synthase
transcript id: NM_001182595.1
SIO_010081: YMR095C
subclass of: SO_0000673
so part of: YMR095C
location: complement(<457285..>457959)
location: region:457285-457959:-1
so has part: feature:457285-457959:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:457285-457959:-1:exon

YMR095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNO1
locus tag: YMR095C
EC number: 3.5.1.2
EC number: 4.3.3.6
experiment: EXISTENCE:direct assay:GO:0004359 glutaminase activity [PMID:14764090]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:14764090]
experiment: EXISTENCE:mutant phenotype:GO:0036001 'de novo' pyridoxal 5'-phosphate biosynthetic process [PMID:30498136]
experiment: EXISTENCE:mutant phenotype:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]
experiment: EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:18355271]
experiment: EXISTENCE:physical interaction:GO:1903600 glutaminase complex [PMID:14764090]
note: Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
codon start: 1
product: putative pyridoxal 5'-phosphate synthase
translation: MHKTHSTMSGKSMKVIGVLALQGAFLEHTNHLKRCLAENDYGIKIEIKTVKTPEDLAQCDALIIPGGESTSMSLIAQRTGLYPCLYEFVHNPEKVVWGTCAGLIFLSAQLENESALVKTLGVLKVDVRRNAFGRQAQSFTQKCDFSNFIPGCDNFPATFIRAPVIERILDPIAVKSLYELPVNGKDVVVAATQNHNILVTSFHPELADSDTRFHDWFIRQFVSN
SIO_010081: YMR095C
subclass of: SO_0000673
so part of: YMR095C
location: complement(457285..457959)
location: region:457285-457959:-1
so has part: feature:457285-457959:-1:exon

NP_013813.1
type: Protein
SIO_000068: ncbiprotein

S000004701
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:457285-457959:-1:exon

YMR096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNZ1
locus tag: YMR096W
so part of: sequence
location: <458408..>459301
location: region:458408-459301:1
so has part: feature:458408-459301:1:exon
subclass of: SO_0000010

855121
type: Gene
SIO_000068: ncbigene

position:458408:1
position: 458408
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:459301:1
position: 459301
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458408-459301:1:exon

YMR096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNZ1
locus tag: YMR096W
product: pyridoxine biosynthesis protein SNZ1
transcript id: NM_001182596.1
SIO_010081: YMR096W
subclass of: SO_0000673
so part of: YMR096W
location: <458408..>459301
location: region:458408-459301:1
so has part: feature:458408-459301:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:458408-459301:1:exon

YMR096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNZ1
locus tag: YMR096W
EC number: 4.3.3.6
experiment: EXISTENCE:direct assay:GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [PMID:19523954]
experiment: EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:14764090|PMID:30498136]
experiment: EXISTENCE:mutant phenotype:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]
experiment: EXISTENCE:mutant phenotype:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]
experiment: EXISTENCE:physical interaction:GO:1903600 glutaminase complex [PMID:14764090]
note: Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3
codon start: 1
product: pyridoxine biosynthesis protein SNZ1
translation: MTGEDFKIKSGLAQMLKGGVIMDVVTPEQAKIAEKSGACAVMALESIPADMRKSGKVCRMSDPKMIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDESEVLTPADWTHHIEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHIRRITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGGVATPADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKLLEVSSDLGELMGGVSIESISHASNGVRLSEIGW
SIO_010081: YMR096W
subclass of: SO_0000673
so part of: YMR096W
location: 458408..459301
location: region:458408-459301:1
so has part: feature:458408-459301:1:exon

NP_013814.1
type: Protein
SIO_000068: ncbiprotein

S000004702
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458408-459301:1:exon

YMR097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTG1
locus tag: YMR097C
so part of: sequence
location: complement(<459424..>460527)
location: region:459424-460527:-1
so has part: feature:459424-460527:-1:exon
subclass of: SO_0000010

855122
type: Gene
SIO_000068: ncbigene

position:459424:-1
position: 459424
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:460527:-1
position: 460527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459424-460527:-1:exon

YMR097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTG1
locus tag: YMR097C
product: putative GTPase MTG1
transcript id: NM_001182597.1
SIO_010081: YMR097C
subclass of: SO_0000673
so part of: YMR097C
location: complement(<459424..>460527)
location: region:459424-460527:-1
so has part: feature:459424-460527:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:459424-460527:-1:exon

YMR097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTG1
locus tag: YMR097C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12808030]
experiment: EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:12808030]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12808030]
note: Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
codon start: 1
product: putative GTPase MTG1
translation: MHINVRGTRKIISNVSSFTPRYEFPKYSMPLTDFKGHQVKALKTFEKLLPQMNMIIELRDIRAPLSTRNVVFDRIARKEHDVMKLVVYTRKDLMPGNKPYIGKLKNWHEELGEKFILLDCRNKTDVRNLLKILEWQNYELETNGGYLPMGYRALITGMPNVGKSTLINSLRTIFHNQVNMGRKFKKVAKTGAEAGVTRATSEVIRVTSRNTESRNEIYLIDTPGIGVPGRVSDHNRMLGLALCGSVKNNLVDPIFQADYLLYLMNLQNLNDGRTELYPGSTNSPTNDIYDVLRRLQVNKSQNEKSTAIEWTNKWRLHGKGIIFDPEVLLNNDEFSYKNYVNDQLEKLGDLSYEGLSNKLKGNPNQVF
SIO_010081: YMR097C
subclass of: SO_0000673
so part of: YMR097C
location: complement(459424..460527)
location: region:459424-460527:-1
so has part: feature:459424-460527:-1:exon

NP_013815.1
type: Protein
SIO_000068: ncbiprotein

S000004703
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459424-460527:-1:exon

YMR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP25
locus tag: YMR098C
so part of: sequence
location: complement(<460771..>462609)
location: region:460771-462609:-1
so has part: feature:460771-462609:-1:exon
subclass of: SO_0000010

855123
type: Gene
SIO_000068: ncbigene

position:460771:-1
position: 460771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462609:-1
position: 462609
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:460771-462609:-1:exon

YMR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP25
locus tag: YMR098C
product: Atp25p
transcript id: NM_001182598.1
SIO_010081: YMR098C
subclass of: SO_0000673
so part of: YMR098C
location: complement(<460771..>462609)
location: region:460771-462609:-1
so has part: feature:460771-462609:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:460771-462609:-1:exon

YMR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP25
locus tag: YMR098C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18216280]
experiment: EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:18216280]
experiment: EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:18216280]
note: Protein that associates with mitochondrial ribosome; required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene
codon start: 1
product: Atp25p
translation: MNKFCLLPFHGKRIGVANIPFTILFKKGPYFLHSHITAVYYSTKGKNDSHEQSRVSKKSTFTPLETPWYLRIVDNEKELMEGKKNNHHTMNKELEIPKTSPNSLRKIADLLTGKLGLDDFLVFDLRKKSPNSVSAVNKLGDFMVICTARSTKHCHKSFLELNKFLKHEFCSSAYVEGNFNERQESRRKRRLARKSNLSKLLGRSSECSAKDLNSEAWYMIDCRVDGIFVNILTQRRRNELNLEELYAPENEKSKFQNIDSGNVPTISGVNEISSNNNILLGLRRLAQQRRRYSTINPNGLSNLRYFLQKEDFKGANKIIQSSSGTETHNIRTLEHVKNTLKDLVGQERKVDVVQWKSLFDEHSTFLTINQSAAYWPLRLEYAILLNKADPQFYSDRVFLKDYLLLKKSLGQELIREDLIALLEMVLKTQHSSHSYFNLVKQNRVIIRALNLFKGLQTEDDGSVVYDEVVISLLLNSMVADERVKLRSLYETIDHIFQTFGDKLTSGMIVSILQNLAKIKDWNKLLQVWEAITPTEGEGQDKRPWNEFINVINQSGDSHVISKIVNNGHLLWIRRLNVNVTPELCNSIKALLKTAGMENSTLEEFLVRGTNNQ
SIO_010081: YMR098C
subclass of: SO_0000673
so part of: YMR098C
location: complement(460771..462609)
location: region:460771-462609:-1
so has part: feature:460771-462609:-1:exon

NP_013816.1
type: Protein
SIO_000068: ncbiprotein

S000004704
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:460771-462609:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(463128..463461)
location: region:463128-463461:-1
so has part: feature:463128-463461:-1:region

S000007114
type: SGD
SIO_000068: sgd

position:463128:-1
position: 463128
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:463461:-1
position: 463461
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463128-463461:-1:region

YNCM0024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0024W
so part of: sequence
location: 463554..463625
location: region:463554-463625:1
so has part: feature:463554-463625:1:exon
subclass of: SO_0000663

855124
type: Gene
SIO_000068: ncbigene

position:463554:1
position: 463554
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:463625:1
position: 463625
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463554-463625:1:exon

YNCM0024W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0024W
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0024W
subclass of: SO_0000673
so part of: YNCM0024W
location: 463554..463625
location: region:463554-463625:1
so has part: feature:463554-463625:1:exon

S000006543
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:463554-463625:1:exon

YMR099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR099C
so part of: sequence
location: complement(<463934..>464827)
location: region:463934-464827:-1
so has part: feature:463934-464827:-1:exon
subclass of: SO_0000010

855125
type: Gene
SIO_000068: ncbigene

position:463934:-1
position: 463934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464827:-1
position: 464827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463934-464827:-1:exon

YMR099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR099C
product: glucose-6-phosphate 1-epimerase
transcript id: NM_001182599.1
SIO_010081: YMR099C
subclass of: SO_0000673
so part of: YMR099C
location: complement(<463934..>464827)
location: region:463934-464827:-1
so has part: feature:463934-464827:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:463934-464827:-1:exon

YMR099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR099C
EC number: 5.1.3.15
experiment: EXISTENCE:curator inference:GO:0044262 cellular carbohydrate metabolic process [PMID:16857670]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0047938 glucose-6-phosphate 1-epimerase activity [PMID:16857670]
note: Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
codon start: 1
product: glucose-6-phosphate 1-epimerase
translation: MPIKETDKEVVLTHPADETTSVHILKYGATVYSWKLKSEEQLWLSTAAKLDGSKPVRGGIPLVFPVFGKNSTDEHLSKLPQHGLARNSTWEFLGQTKENPPTVQFGLKPEIANPELTKLWPMDYLLILTVELGSDYLKTAIEVENTSSSKELKFNWLFHTYFRIEDIEGTMVSNLAGMKLYDQLLKESYVDKHPVVTFNQETDVIYQNVSAERAIQIVDKGVQIHTLKRYNLPDTVVWNPWIEKSQGMADFEPKTGYQQMICIEPGHVHDFISLAPGKKWNAYQLLCKEELKYQAIQ
SIO_010081: YMR099C
subclass of: SO_0000673
so part of: YMR099C
location: complement(463934..464827)
location: region:463934-464827:-1
so has part: feature:463934-464827:-1:exon

NP_013817.1
type: Protein
SIO_000068: ncbiprotein

S000004705
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:463934-464827:-1:exon

YMR100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MUB1
locus tag: YMR100W
so part of: sequence
location: <466300..>468162
location: region:466300-468162:1
so has part: feature:466300-468162:1:exon
subclass of: SO_0000010

855126
type: Gene
SIO_000068: ncbigene

position:466300:1
position: 466300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:468162:1
position: 468162
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466300-468162:1:exon

YMR100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MUB1
locus tag: YMR100W
product: Mub1p
transcript id: NM_001182600.1
SIO_010081: YMR100W
subclass of: SO_0000673
so part of: YMR100W
location: <466300..>468162
location: region:466300-468162:1
so has part: feature:466300-468162:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466300-468162:1:exon

YMR100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MUB1
locus tag: YMR100W
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:18070918]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:18070918]
experiment: EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]
note: MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; proposed to function as both a partner and substrate of the Ubr2p/Rad6p ubiquitin ligase; similar to the A. nidulans samB gene
codon start: 1
product: Mub1p
translation: MRDSNHRSLTSNKPIVTITSTVYDRRALDINSSIPLINSLNYLTYLTSNSSKVRETVANDGALERLVSILRSCHLSLFELLDLDLENFNEHENIKDLWKEKRLALCAWKWTLTFQCLVLTGTRGTEQIRKKVVMSGVLSVLVTVLDNYLLYHKNYDFIKDQTMTFDFKGITTETMYKFMRKDENETYQQYIEFITGQDKLKLSTDKNFLNERLVAPSMTIPTDFSDIWGRFADLASNFEPDQERHDDDIDIDSEVESENFDAHKNFFSQPDINRPTISTPREFFLGRIVPKQDDVIWSLQLLAFVSKYTYMKSTLQNVELVESLSFRSMAYKIKQRISEENDLEEQERDVTVKLSSLYPYLSKNPENNSKVKALDTSKMDPFFKELEELSNRCQQEEQNEICNNHCPVLNLFERYRVPKPSDDNAYGKDKERINLRKKISDNFERRWSYDKMKKELTNIVYKNKVLTNVVNIFPLVEKYTVSAENTHDVIYWSSVIMRNSCRKNEILGVRQCANFSCGKWEDFPRQFAKCRRCKRTKYCSRKCQLKAWGYHRYWCHEVGSSHMRSTNTTTGVNTPNEPSSLNATATTAADVSNSTSTFTPNISTTVPDEISNRDENSIPE
SIO_010081: YMR100W
subclass of: SO_0000673
so part of: YMR100W
location: 466300..468162
location: region:466300-468162:1
so has part: feature:466300-468162:1:exon

NP_013818.1
type: Protein
SIO_000068: ncbiprotein

S000004706
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466300-468162:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1316; Autonomously Replicating Sequence
so part of: sequence
location: 468179..468469
location: region:468179-468469:1
so has part: feature:468179-468469:1:region

S000118372
type: SGD
SIO_000068: sgd

position:468179:1
position: 468179
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:468469:1
position: 468469
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468179-468469:1:region

YMR101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRT1
locus tag: YMR101C
so part of: sequence
location: complement(<468445..>469476)
location: region:468445-469476:-1
so has part: feature:468445-469476:-1:exon
subclass of: SO_0000010

855127
type: Gene
SIO_000068: ncbigene

position:468445:-1
position: 468445
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:469476:-1
position: 469476
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468445-469476:-1:exon

YMR101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRT1
locus tag: YMR101C
product: ditrans,polycis-polyprenyl diphosphate synthase
transcript id: NM_001182601.1
SIO_010081: YMR101C
subclass of: SO_0000673
so part of: YMR101C
location: complement(<468445..>469476)
location: region:468445-469476:-1
so has part: feature:468445-469476:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:468445-469476:-1:exon

YMR101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRT1
locus tag: YMR101C
EC number: 2.5.1.87
experiment: EXISTENCE:direct assay:GO:0004659 prenyltransferase activity [PMID:17345630]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:11442630|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0006486 protein glycosylation [PMID:11442630]
experiment: EXISTENCE:direct assay:GO:0019408 dolichol biosynthetic process [PMID:25066056]
experiment: EXISTENCE:direct assay:GO:0045547 dehydrodolichyl diphosphate synthase activity [PMID:11442630|PMID:25066056]
experiment: EXISTENCE:direct assay:GO:1904423 dehydrodolichyl diphosphate synthase complex [PMID:25066056]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:11442630]
note: Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
codon start: 1
product: ditrans,polycis-polyprenyl diphosphate synthase
translation: MKMPSIIQIQFVALKRLLVETKEQMCFAVKSIFQRVFAWVMSLSLFSWFYVNLQNILIKALRVGPVPEHVSFIMDGNRRYAKSRRLPVKKGHEAGGLTLLTLLYICKRLGVKCVSAYAFSIENFNRPKEEVDTLMNLFTVKLDEFAKRAKDYKDPLYGSKIRIVGDQSLLSPEMRKKIKKVEEITQDGDDFTLFICFPYTSRNDMLHTIRDSVEDHLENKSPRINIRKFTNKMYMGFHSNKCELLIRTSGHRRLSDYMLWQVHENATIEFSDTLWPNFSFFAMYLMILKWSFFSTIQKYNEKNHSLFEKIHESVPSIFKKKKTAMSLYNFPNPPISVSVTGDE
SIO_010081: YMR101C
subclass of: SO_0000673
so part of: YMR101C
location: complement(468445..469476)
location: region:468445-469476:-1
so has part: feature:468445-469476:-1:exon

NP_013819.1
type: Protein
SIO_000068: ncbiprotein

S000004707
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468445-469476:-1:exon

YMR102C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LAF1
locus tag: YMR102C
so part of: sequence
location: complement(<469848..>472352)
location: region:469848-472352:-1
so has part: feature:469848-472352:-1:exon
subclass of: SO_0000010

855128
type: Gene
SIO_000068: ncbigene

position:469848:-1
position: 469848
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472352:-1
position: 472352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469848-472352:-1:exon

YMR102C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LAF1
locus tag: YMR102C
product: Laf1p
transcript id: NM_001182602.1
SIO_010081: YMR102C
subclass of: SO_0000673
so part of: YMR102C
location: complement(<469848..>472352)
location: region:469848-472352:-1
so has part: feature:469848-472352:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469848-472352:-1:exon

YMR102C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LAF1
locus tag: YMR102C
experiment: EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:33255682]
note: Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication
codon start: 1
product: Laf1p
translation: MTNMAEDKTSISKVHSEFSNSSNTTGSEEESRSHQESFDGESSSGESKSKSKLNLEYSADIEPLKFRMTKTNNTNDKLKYSNNGNATDSFMRLKEHLQRGNTLNSNLRVNEFYPFNSIDTEQFENYLREPKYIKMLKRRKNLKQFRRLFLAQELMAYEGETVTSTSKSSEPTSKAIWSTKFSRDGKFMATGSKDGKIRIWKVIGSPVERAELDSSAESNKEARAKSMRIKQQVSSLNNPKEKQFLDSATEKYEEKEKLLNLYAPVFHPTPLRLYKEHVQDVLDINWSKNNFILSASMDKTVKLWHPDRKNSLKTFIHPDFVTCVEFHPTDDRFFISGCLDHKCRLWSILDDEVSFEYDCQDLITSVTLSPEEGKYTIIGTFNGYVHILMTRGLTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSNDSRIRIFDLEQRKLLEVLKGFHSGSSQHKAQLSIWHGQPIVVNSSDDHWVYGWRLKSSDRENDQDEPKRKPKGLARSGSLRSIFSKSMSRSSSQNNEEKPHHHLKLTNLLPLPHHSNDHYIKNTDYISFHAHNAPVTCVSIAPPETSKTLSLSNDVICELSLEFFQTSDSFDVLSRSNDDGIMSDVESSLGYNSKPGSISNASATSAIPDVVDAIGTILISTDNVGTIRVFRADMPSVIRKRVLLKLEEYNREVRRRFNSSDSLHSLSRSFNSRAKSNLAGQPAAAYTNTGKGYATGRGYSNICPKSSTSLKTLGSNAQPRTPRESMSSIFSNAHGPTTPTSAMNLPIRCNVCNGSRFEAFSGANDQQDRNYYCVDCGTVVNNFR
SIO_010081: YMR102C
subclass of: SO_0000673
so part of: YMR102C
location: complement(469848..472352)
location: region:469848-472352:-1
so has part: feature:469848-472352:-1:exon

NP_013820.1
type: Protein
SIO_000068: ncbiprotein

S000004708
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469848-472352:-1:exon

YMR103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR103C
so part of: sequence
location: complement(<472902..>473264)
location: region:472902-473264:-1
so has part: feature:472902-473264:-1:exon
subclass of: SO_0000010

855129
type: Gene
SIO_000068: ncbigene

position:472902:-1
position: 472902
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:473264:-1
position: 473264
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472902-473264:-1:exon

YMR103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR103C
product: uncharacterized protein
transcript id: NM_001348866.1
SIO_010081: YMR103C
subclass of: SO_0000673
so part of: YMR103C
location: complement(<472902..>473264)
location: region:472902-473264:-1
so has part: feature:472902-473264:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472902-473264:-1:exon

YMR103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR103C
note: hypothetical protein; conserved among S. cerevisiae strains; YMR103C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MVRRGCALLLATLTRLMLLIHFFYSIIRILPSTELRSKTDLLSAEGRTLIPADVKAKPAGRKSRLPEFAKRQRTLALPERKDSLFCLLPLFLHSLGREQLISSADDPGFPCAGSAMGSLT
SIO_010081: YMR103C
subclass of: SO_0000673
so part of: YMR103C
location: complement(472902..473264)
location: region:472902-473264:-1
so has part: feature:472902-473264:-1:exon

NP_001335806.1
type: Protein
SIO_000068: ncbiprotein

S000004709
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472902-473264:-1:exon

YMR104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKR2
gene: YPK2
locus tag: YMR104C
gene synonym: YKR2
so part of: sequence
location: complement(<473420..>475453)
location: region:473420-475453:-1
so has part: feature:473420-475453:-1:exon
subclass of: SO_0000010

855130
type: Gene
SIO_000068: ncbigene

position:473420:-1
position: 473420
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475453:-1
position: 475453
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:473420-475453:-1:exon

YMR104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKR2
gene: YPK2
locus tag: YMR104C
gene synonym: YKR2
product: putative protein kinase YPK2
transcript id: NM_001182604.1
SIO_010081: YMR104C
subclass of: SO_0000673
so part of: YMR104C
location: complement(<473420..>475453)
location: region:473420-475453:-1
so has part: feature:473420-475453:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:473420-475453:-1:exon

YMR104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKR2
gene: YPK2
locus tag: YMR104C
gene synonym: YKR2
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:16478726]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12221112]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]
experiment: EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:18296441]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16478726]
note: AGC-type S/T protein kinase; participates in the cell wall integrity signaling pathway; involved with Ypk1p in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6), and in the direct phosphorylation of the Myo5p motor domain TEDS site; phosphorylated and activated by Pkh1/2p in the presence of phytosphingosine; direct phosphorylation by Tor2p regulates actin polarization; genetically redundant with YPK1; human homolog SGK2 can complement the inviability of a ypk1 ypk2 mutant
codon start: 1
product: putative protein kinase YPK2
translation: MHSWRISKFKLGRSKEDDGSSEDENEKSWGNGLFHFHHGEKHHDGSPKNHNHEHEHHIRKINTNETLPSSLSSPKLRNDASFKNPSGIGNDNSKASERKASQSSTETQGPSSESGLMTVKVYSGKDFTLPFPITSNSTILQKLLSSGILTSSSNDASEVAAIMRQLPRYKRVDQDSAGEGLIDRAFATKFIPSSILLPGSTNSSPLLYFTIEFDNSITTISPDMGTMEQPVFNKISTFDVTRKLRFLKIDVFARIPSLLLPSKNWQQEIGEQDEVLKEILKKINTNQDIHLDSFHLPLNLKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPSKNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPPYYDENVPVMYKKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEYLSASIQKQFGGWTYIGDEQLGDSPSQGRSIS
SIO_010081: YMR104C
subclass of: SO_0000673
so part of: YMR104C
location: complement(473420..475453)
location: region:473420-475453:-1
so has part: feature:473420-475453:-1:exon

NP_013822.1
type: Protein
SIO_000068: ncbiprotein

S000004710
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:473420-475453:-1:exon

YMR105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GAL5
gene: PGM2
locus tag: YMR105C
gene synonym: GAL5
so part of: sequence
location: complement(<475897..>477606)
location: region:475897-477606:-1
so has part: feature:475897-477606:-1:exon
subclass of: SO_0000010

855131
type: Gene
SIO_000068: ncbigene

position:475897:-1
position: 475897
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:477606:-1
position: 477606
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475897-477606:-1:exon

YMR105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GAL5
gene: PGM2
locus tag: YMR105C
gene synonym: GAL5
product: phosphoglucomutase PGM2
transcript id: NM_001182605.1
SIO_010081: YMR105C
subclass of: SO_0000673
so part of: YMR105C
location: complement(<475897..>477606)
location: region:475897-477606:-1
so has part: feature:475897-477606:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:475897-477606:-1:exon

YMR105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GAL5
gene: PGM2
locus tag: YMR105C
gene synonym: GAL5
EC number: 5.4.2.2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8385141]
experiment: EXISTENCE:genetic interaction:GO:0004614 phosphoglucomutase activity [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0006011 UDP-glucose metabolic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0006874 cellular calcium ion homeostasis [PMID:15252028]
experiment: EXISTENCE:genetic interaction:GO:0019255 glucose 1-phosphate metabolic process [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0051156 glucose 6-phosphate metabolic process [PMID:8119301]
experiment: EXISTENCE:mutant phenotype:GO:0004614 phosphoglucomutase activity [PMID:2138705|PMID:8119301|PMID:13887540]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:10681519|PMID:15252028]
experiment: EXISTENCE:mutant phenotype:GO:0019255 glucose 1-phosphate metabolic process [PMID:10681519|PMID:8119301]
experiment: EXISTENCE:mutant phenotype:GO:0019388 galactose catabolic process [PMID:8119301|PMID:13887540|PMID:14264884]
experiment: EXISTENCE:mutant phenotype:GO:0030003 cellular cation homeostasis [PMID:15164360]
note: Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication
codon start: 1
product: phosphoglucomutase PGM2
translation: MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVGGDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASHNPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYGPLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVDEFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYGYGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKTIQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCGDFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAEEYLKPIINSVIKFLNFKQVLGTEEPTVRT
SIO_010081: YMR105C
subclass of: SO_0000673
so part of: YMR105C
location: complement(475897..477606)
location: region:475897-477606:-1
so has part: feature:475897-477606:-1:exon

NP_013823.1
type: Protein
SIO_000068: ncbiprotein

S000004711
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475897-477606:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1317; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 477606..478301
location: region:477606-478301:1
so has part: feature:477606-478301:1:region

S000130188
type: SGD
SIO_000068: sgd

position:477606:1
position: 477606
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:478301:1
position: 478301
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:477606-478301:1:region

YMR105W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR105W-A
so part of: sequence
location: <478064..>478258
location: region:478064-478258:1
so has part: feature:478064-478258:1:exon
subclass of: SO_0000010

1466500
type: Gene
SIO_000068: ncbigene

position:478064:1
position: 478064
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478258:1
position: 478258
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:478064-478258:1:exon

YMR105W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR105W-A
product: uncharacterized protein
transcript id: NM_001184614.1
SIO_010081: YMR105W-A
subclass of: SO_0000673
so part of: YMR105W-A
location: <478064..>478258
location: region:478064-478258:1
so has part: feature:478064-478258:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:478064-478258:1:exon

YMR105W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR105W-A
codon start: 1
product: uncharacterized protein
translation: MILVHTGNVLYPRFIVVAFTFEQRQGGRCKGGKATCMASVQSYKVTMQISSMTIIYPLFIFFSL
SIO_010081: YMR105W-A
subclass of: SO_0000673
so part of: YMR105W-A
location: 478064..478258
location: region:478064-478258:1
so has part: feature:478064-478258:1:exon

NP_878142.1
type: Protein
SIO_000068: ncbiprotein

S000028692
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:478064-478258:1:exon

YMR106C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HDF2
gene: YKU80
locus tag: YMR106C
gene synonym: HDF2
so part of: sequence
location: complement(<478301..>480190)
location: region:478301-480190:-1
so has part: feature:478301-480190:-1:exon
subclass of: SO_0000010

855132
type: Gene
SIO_000068: ncbigene

position:478301:-1
position: 478301
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:480190:-1
position: 480190
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:478301-480190:-1:exon

YMR106C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HDF2
gene: YKU80
locus tag: YMR106C
gene synonym: HDF2
product: ATP-dependent DNA helicase YKU80
transcript id: NM_001182606.1
SIO_010081: YMR106C
subclass of: SO_0000673
so part of: YMR106C
location: complement(<478301..>480190)
location: region:478301-480190:-1
so has part: feature:478301-480190:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:478301-480190:-1:exon

YMR106C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HDF2
gene: YKU80
locus tag: YMR106C
gene synonym: HDF2
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16166630]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:11553718]
experiment: EXISTENCE:direct assay:GO:0007535 donor selection [PMID:16166630]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]
experiment: EXISTENCE:direct assay:GO:0043564 Ku70:Ku80 complex [PMID:8754818]
experiment: EXISTENCE:direct assay:GO:0070034 telomerase RNA binding [PMID:12975323]
experiment: EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:16809780]
experiment: EXISTENCE:genetic interaction:GO:0034502 protein localization to chromosome [PMID:18716325]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:9501103]
experiment: EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:11016833]
experiment: EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]
experiment: EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:16166630|PMID:16809780]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9501103]
experiment: EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:15531893]
note: Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters
codon start: 1
product: ATP-dependent DNA helicase YKU80
translation: MSSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLANCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEGLQSMIQCLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILIDCGKDTQEERKKSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDELPEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPTVFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIKKVDKLKLDSELKTELEREKIPDLETLLKRGEQHSRGSPNNSNN
SIO_010081: YMR106C
subclass of: SO_0000673
so part of: YMR106C
location: complement(478301..480190)
location: region:478301-480190:-1
so has part: feature:478301-480190:-1:exon

NP_013824.1
type: Protein
SIO_000068: ncbiprotein

S000004712
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:478301-480190:-1:exon

YNCM0025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0025C
so part of: sequence
location: complement(480621..480693)
location: region:480621-480693:-1
so has part: feature:480621-480693:-1:exon
subclass of: SO_0000663

855133
type: Gene
SIO_000068: ncbigene

position:480621:-1
position: 480621
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:480693:-1
position: 480693
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:480621-480693:-1:exon

YNCM0025C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0025C
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCM0025C
subclass of: SO_0000673
so part of: YNCM0025C
location: complement(480621..480693)
location: region:480621-480693:-1
so has part: feature:480621-480693:-1:exon

S000006627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:480621-480693:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(481214..481547)
location: region:481214-481547:-1
so has part: feature:481214-481547:-1:region

S000007115
type: SGD
SIO_000068: sgd

position:481214:-1
position: 481214
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:481547:-1
position: 481547
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:481214-481547:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 481571..481808
location: region:481571-481808:1
so has part: feature:481571-481808:1:region

S000007122
type: SGD
SIO_000068: sgd

position:481571:1
position: 481571
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:481808:1
position: 481808
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:481571-481808:1:region

YMR107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPG4
locus tag: YMR107W
so part of: sequence
location: <483014..>483361
location: region:483014-483361:1
so has part: feature:483014-483361:1:exon
subclass of: SO_0000010

855134
type: Gene
SIO_000068: ncbigene

position:483014:1
position: 483014
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483361:1
position: 483361
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483014-483361:1:exon

YMR107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPG4
locus tag: YMR107W
product: Spg4p
transcript id: NM_001182607.1
SIO_010081: YMR107W
subclass of: SO_0000673
so part of: YMR107W
location: <483014..>483361
location: region:483014-483361:1
so has part: feature:483014-483361:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483014-483361:1:exon

YMR107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPG4
locus tag: YMR107W
note: Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources
codon start: 1
product: Spg4p
translation: MGSFWDAFAVYDKKKHADPSVYGGNHNNTGDSKTQVMFSKEYRQPRTHQQENLQSMRRSSIGSQDSSDVEDVKEGRLPAEVEIPKNVDISNMSQGEFLRLYESLRRGEPDNKVNR
SIO_010081: YMR107W
subclass of: SO_0000673
so part of: YMR107W
location: 483014..483361
location: region:483014-483361:1
so has part: feature:483014-483361:1:exon

NP_013825.1
type: Protein
SIO_000068: ncbiprotein

S000004713
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483014-483361:1:exon

YMR108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SMR1
alternative label: THI1
gene: ILV2
locus tag: YMR108W
gene synonym: SMR1; THI1
so part of: sequence
location: <484084..>486147
location: region:484084-486147:1
so has part: feature:484084-486147:1:exon
subclass of: SO_0000010

855135
type: Gene
SIO_000068: ncbigene

position:484084:1
position: 484084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486147:1
position: 486147
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484084-486147:1:exon

YMR108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SMR1
alternative label: THI1
gene: ILV2
locus tag: YMR108W
gene synonym: SMR1; THI1
product: acetolactate synthase catalytic subunit
transcript id: NM_001182608.1
SIO_010081: YMR108W
subclass of: SO_0000673
so part of: YMR108W
location: <484084..>486147
location: region:484084-486147:1
so has part: feature:484084-486147:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:484084-486147:1:exon

YMR108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SMR1
alternative label: THI1
gene: ILV2
locus tag: YMR108W
gene synonym: SMR1; THI1
EC number: 2.2.1.6
experiment: EXISTENCE:direct assay:GO:0003984 acetolactate synthase activity [PMID:10213630]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005948 acetolactate synthase complex [PMID:10213630]
experiment: EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:2406721]
experiment: EXISTENCE:direct assay:GO:0050660 flavin adenine dinucleotide binding [PMID:15709745]
experiment: EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:2406721]
note: Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
codon start: 1
product: acetolactate synthase catalytic subunit
translation: MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYYSASPLPASKRPEPAPSFNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH
SIO_010081: YMR108W
subclass of: SO_0000673
so part of: YMR108W
location: 484084..486147
location: region:484084-486147:1
so has part: feature:484084-486147:1:exon

NP_013826.1
type: Protein
SIO_000068: ncbiprotein

S000004714
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:484084-486147:1:exon

YMR109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MYO5
locus tag: YMR109W
so part of: sequence
location: <486587..>490246
location: region:486587-490246:1
so has part: feature:486587-490246:1:exon
subclass of: SO_0000010

855136
type: Gene
SIO_000068: ncbigene

position:486587:1
position: 486587
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490246:1
position: 490246
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486587-490246:1:exon

YMR109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MYO5
locus tag: YMR109W
product: myosin 5
transcript id: NM_001182609.1
SIO_010081: YMR109W
subclass of: SO_0000673
so part of: YMR109W
location: <486587..>490246
location: region:486587-490246:1
so has part: feature:486587-490246:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486587-490246:1:exon

YMR109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MYO5
locus tag: YMR109W
experiment: EXISTENCE:direct assay:GO:0000146 microfilament motor activity [PMID:16824951]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:20647997]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:16824951]
experiment: EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:12391157]
experiment: EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18177206]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16824951]
experiment: EXISTENCE:mutant phenotype:GO:0006898 receptor-mediated endocytosis [PMID:8614799]
experiment: EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18177206]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:mutant phenotype:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:16824951]
experiment: EXISTENCE:physical interaction:GO:0009651 response to salt stress [PMID:12391157]
note: One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication
codon start: 1
product: myosin 5
translation: MAILKRGARKKVHQEPAKRSANIKKATFDSSKKKEVGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASSTHTESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLEKQRVVSQIKNERNFHIFYQFTKGASDAYRQTFGVQKPEQYVYTAAAGCISAETIDDLQDYQETLKAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGNAQVRDTSVTDFVAYLLQIDSQLLIKSLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVVCDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRLNLFTTNPHFDLRSNKFVIKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDRESKRRPPTAGDKIIKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFEKFVERFYLLSPHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALEHMRDRYWHNMAARIQRAWRRFLQRRIDAATKIQRTIRERKEGNKYEKLRDYGTKVLGGRKERRSMSLLGYRAFMGDYLSCNESKSKGAYIKRQVSIKEKVIFSIHGEALHTKFGRSAQRLKKTFLLTPTTLYIVGQTLVQNAMTYTQDYKIDVRNIQAVSLTNLQDDWVAIKLASSGQPDPLINTYFKTELITHLKRLNDKIQIKIGSAIEYQKKPGKLHSVKCQINESAPKYGDIYKSSTISVRRGNPPNSQVHKKPRKKSSISSGYHASSSQATRRPVSIAAAQHVPTAPASRHSKKPAPPPPGMQNKAATRRSVPNPASTLTASQSNARPSPPTAATRATPAATPAAAAMGSGRQANIPPPPPPPPPSSKPKEPMFEAAYDFPGSGSPSELPLKKGDVIYITREEPSGWSLGKLLDGSKEGWVPTAYMKPHSGNNNIPTPPQNRDVPKPVLNSVQHDNTSANVIPAAAQASLGDGLANALAARANKMRLESDDEEANEDEEEDDW
SIO_010081: YMR109W
subclass of: SO_0000673
so part of: YMR109W
location: 486587..490246
location: region:486587-490246:1
so has part: feature:486587-490246:1:exon

NP_013827.1
type: Protein
SIO_000068: ncbiprotein

S000004715
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486587-490246:1:exon

YMR110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HFD1
locus tag: YMR110C
so part of: sequence
location: complement(<490394..>491992)
location: region:490394-491992:-1
so has part: feature:490394-491992:-1:exon
subclass of: SO_0000010

855137
type: Gene
SIO_000068: ncbigene

position:490394:-1
position: 490394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:491992:-1
position: 491992
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490394-491992:-1:exon

YMR110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HFD1
locus tag: YMR110C
product: hexadecenal dehydrogenase
transcript id: NM_001182610.1
SIO_010081: YMR110C
subclass of: SO_0000673
so part of: YMR110C
location: complement(<490394..>491992)
location: region:490394-491992:-1
so has part: feature:490394-491992:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490394-491992:-1:exon

YMR110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HFD1
locus tag: YMR110C
EC number: 1.2.1.3
EC number: 1.2.1.64
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006081 cellular aldehyde metabolic process [PMID:22633490]
experiment: EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:22633490]
experiment: EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:27669165]
experiment: EXISTENCE:mutant phenotype:GO:0018484 4-hydroxybenzaldehyde dehydrogenase activity [PMID:27693056|PMID:33862086|PMID:27669165]
experiment: EXISTENCE:mutant phenotype:GO:0032180 ubiquinone biosynthetic process from tyrosine [PMID:27693056|PMID:33862086]
experiment: EXISTENCE:mutant phenotype:GO:0046185 aldehyde catabolic process [PMID:25545362]
experiment: EXISTENCE:mutant phenotype:GO:0047770 carboxylate reductase activity [PMID:22633490]
note: Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2
codon start: 1
product: hexadecenal dehydrogenase
translation: MSNDGSKILNYTPVSKIDEIVEISRNFFFEKQLKLSHENNPRKKDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRNKIESVLNETTKLMNDILHLIEILPKLIKPRRVSDSSPPFMFGKTIVEKISRGSVLIIAPFNFPLLLAFAPLAAALAAGNTIVLKPSELTPHTAVVMENLLTTAGFPDGLIQVVQGAIDETTRLLDCGKFDLIFYTGSPRVGSIVAEKAAKSLTPCVLELGGKSPTFITENFKASNIKIALKRIFFGAFGNSGQICVSPDYLLVHKSIYPKVIKECESVLNEFYPSFDEQTDFTRMIHEPAYKKAVASINSTNGSKIVPSKISINSDTEDLCLVPPTIVYNIGWDDPLMKQENFAPVLPIIEYEDLDETINKIIEEHDTPLVQYIFSDSQTEINRILTRLRSGDCVVGDTVIHVGITDAPFGGIGTSGYGNYGGYYGFNTFSHERTIFKQPYWNDFTLFMRYPPNSAQKEKLVRFAMERKPWFDRNGNNKWGLRQYFSLSAAVILISTIYAHCSS
SIO_010081: YMR110C
subclass of: SO_0000673
so part of: YMR110C
location: complement(490394..491992)
location: region:490394-491992:-1
so has part: feature:490394-491992:-1:exon

NP_013828.1
type: Protein
SIO_000068: ncbiprotein

S000004716
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490394-491992:-1:exon

YMR111C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EUC1
locus tag: YMR111C
so part of: sequence
location: complement(<492404..>493792)
location: region:492404-493792:-1
so has part: feature:492404-493792:-1:exon
subclass of: SO_0000010

855138
type: Gene
SIO_000068: ncbigene

position:492404:-1
position: 492404
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:493792:-1
position: 493792
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492404-493792:-1:exon

YMR111C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EUC1
locus tag: YMR111C
product: Euc1p
transcript id: NM_001182611.1
SIO_010081: YMR111C
subclass of: SO_0000673
so part of: YMR111C
location: complement(<492404..>493792)
location: region:492404-493792:-1
so has part: feature:492404-493792:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:492404-493792:-1:exon

YMR111C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EUC1
locus tag: YMR111C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31015336]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:31015336]
experiment: EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:31015336]
note: Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress
codon start: 1
product: Euc1p
translation: MPAREYNYVEGFGGYGSLDDDDSDRDSERRNHDLGQRTITTSPTGVSRHAALNRYMIPGRINPLFRPTDAAQPPIVSTSTSASATEPTNRIGPGRIKETPETNFNAFLIAQLTRMEEQNANLKEEISLMKKEQELFFLENQKKLEKGFKDINKYVEDVSAMKEVFKEVVGIMTGERIRFIDHTGENVTPQEAARVGNPSTSTQAHQSQSRSTNWQEYSMHASILAGDPRIKPEPGLSDFENGEYDGNESDENATTRNLPLNNPDSVSNADDSNNQLDGTGNENDIRNRRGCVGTSYKLNRAIQNVTDAAREYFEGLPGQPSVLSLERRYGSTWRRSAKERTLFTKRMTIIKRIIDIKDDPSKYGLSLPENKISRNQAIKVVENIRLGNNTFKGHHCRLSMSQLYEYFSKKMDKLEDYSLTLKRRGKPRRIFLLEEREARLSLQQPHSIPNSSTGTPEHDQDT
SIO_010081: YMR111C
subclass of: SO_0000673
so part of: YMR111C
location: complement(492404..493792)
location: region:492404-493792:-1
so has part: feature:492404-493792:-1:exon

NP_013829.1
type: Protein
SIO_000068: ncbiprotein

S000004717
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:492404-493792:-1:exon

YMR112C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MED11
locus tag: YMR112C
so part of: sequence
location: complement(<494100..>494495)
location: region:494100-494495:-1
so has part: feature:494100-494495:-1:exon
subclass of: SO_0000010

855139
type: Gene
SIO_000068: ncbigene

position:494100:-1
position: 494100
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:494495:-1
position: 494495
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494100-494495:-1:exon

YMR112C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MED11
locus tag: YMR112C
product: Med11p
transcript id: NM_001182612.1
SIO_010081: YMR112C
subclass of: SO_0000673
so part of: YMR112C
location: complement(<494100..>494495)
location: region:494100-494495:-1
so has part: feature:494100-494495:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494100-494495:-1:exon

YMR112C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MED11
locus tag: YMR112C
experiment: EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:18691966]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:18691966]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:18691966]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
codon start: 1
product: Med11p
translation: MQVLNTKSETKQENETMQPPYIQERLKSLNDIETQLCSMLQEASQVTFIFGELKRGNESVKPQFENHVKQFYERLDKSTTQLRKEIQLLDENVGTRLLPINVNKKALGQDTEKMEEQLDLLSAILDPSKSK
SIO_010081: YMR112C
subclass of: SO_0000673
so part of: YMR112C
location: complement(494100..494495)
location: region:494100-494495:-1
so has part: feature:494100-494495:-1:exon

NP_013830.1
type: Protein
SIO_000068: ncbiprotein

S000004718
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494100-494495:-1:exon

YMR113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FOL3
locus tag: YMR113W
so part of: sequence
location: <494999..>496282
location: region:494999-496282:1
so has part: feature:494999-496282:1:exon
subclass of: SO_0000010

855140
type: Gene
SIO_000068: ncbigene

position:494999:1
position: 494999
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:496282:1
position: 496282
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494999-496282:1:exon

YMR113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FOL3
locus tag: YMR113W
product: dihydrofolate synthase
transcript id: NM_001182613.1
SIO_010081: YMR113W
subclass of: SO_0000673
so part of: YMR113W
location: <494999..>496282
location: region:494999-496282:1
so has part: feature:494999-496282:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494999-496282:1:exon

YMR113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FOL3
locus tag: YMR113W
EC number: 6.3.2.12
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0008841 dihydrofolate synthase activity [PMID:11731153]
experiment: EXISTENCE:mutant phenotype:GO:0009396 folic acid-containing compound biosynthetic process [PMID:11731153]
note: Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication
codon start: 1
product: dihydrofolate synthase
translation: MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEPLLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN
SIO_010081: YMR113W
subclass of: SO_0000673
so part of: YMR113W
location: 494999..496282
location: region:494999-496282:1
so has part: feature:494999-496282:1:exon

NP_013831.1
type: Protein
SIO_000068: ncbiprotein

S000004719
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494999-496282:1:exon

YMR114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR114C
so part of: sequence
location: complement(<496343..>497449)
location: region:496343-497449:-1
so has part: feature:496343-497449:-1:exon
subclass of: SO_0000010

855141
type: Gene
SIO_000068: ncbigene

position:496343:-1
position: 496343
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:497449:-1
position: 497449
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496343-497449:-1:exon

YMR114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR114C
product: putative peptide hydrolase
transcript id: NM_001182614.1
SIO_010081: YMR114C
subclass of: SO_0000673
so part of: YMR114C
location: complement(<496343..>497449)
location: region:496343-497449:-1
so has part: feature:496343-497449:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:496343-497449:-1:exon

YMR114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR114C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:24390141]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
codon start: 1
product: putative peptide hydrolase
translation: MCGRFALAYDSGDLPQLLRDWNLPVNTPKDASSNSQHPHDEEDTKDQPTVSKDIFKASYNISPTNYSAVYRPDTKAIQFMRWGLVPFWTKDVSQFKTYRTFNARLENLQESKMWMRPCEKKRCAVLMSGYFEWKTVGKKKTPYFISRRDGRLMFVAGMYDYVEKDDLYTFTIITAQGPRELEWLHERMPCVLEPGTESWDAWMDVDKTTWSTEELVKLLKPDYDESKLQFYQVTDDVGKTTNTGERLIKPLLKEDSDMFSVKREKEEALLENDNEQGIDNRGVKGDKSLKGEDVFNQKKSLKRNSYDGLKKNEEQEETTLPEEGSIGDRVKREEANLSPKREGNREKRNIVNMLGNQKDSRGKKKIKK
SIO_010081: YMR114C
subclass of: SO_0000673
so part of: YMR114C
location: complement(496343..497449)
location: region:496343-497449:-1
so has part: feature:496343-497449:-1:exon

NP_013832.1
type: Protein
SIO_000068: ncbiprotein

S000004720
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:496343-497449:-1:exon

YMR115W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP24
gene: MGR3
locus tag: YMR115W
gene synonym: FMP24
so part of: sequence
location: <497704..>499209
location: region:497704-499209:1
so has part: feature:497704-499209:1:exon
subclass of: SO_0000010

855142
type: Gene
SIO_000068: ncbigene

position:497704:1
position: 497704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499209:1
position: 499209
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497704-499209:1:exon

YMR115W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP24
gene: MGR3
locus tag: YMR115W
gene synonym: FMP24
product: Mgr3p
transcript id: NM_001182615.1
SIO_010081: YMR115W
subclass of: SO_0000673
so part of: YMR115W
location: <497704..>499209
location: region:497704-499209:1
so has part: feature:497704-499209:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:497704-499209:1:exon

YMR115W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP24
gene: MGR3
locus tag: YMR115W
gene synonym: FMP24
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18843051]
experiment: EXISTENCE:direct assay:GO:0031942 i-AAA complex [PMID:18843051]
experiment: EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:18843051]
experiment: EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:18843051]
note: Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
codon start: 1
product: Mgr3p
translation: MLLQGMRLSQRLHKRHLFASKILTWTTNPAHIRHLHDIRPPASNFNTQESAPIPESPANSPTRPQMAPKPNLKKKNRSLMYSIIGVSIVGLYFWFKSNSRKQKLPLSAQKVWKEAIWQESDKMDFNYKEALRRYIEALDECDRSHVDLLSDDYTRIELKIAEMYEKLNMLEEAQNLYQELLSRFFEALNVPGKVDESERGEVLRKDLRILIKSLEINKDIESGKRKLLQHLLLAQEEILSKSPELKEFFENRKKKLSMVKDINRDPNDDFKTFVSEENIKFDEQGYMILDLEKNSSAWEPFKEEFFTARDLYTAYCLSSKDIAAALSCKITSVEWMVMADMPPGQILLSQANLGSLFYLQAEKLEADLNQLEQKKSKESNQELDMGTYIKAVRFVRKNRDLCLERAQKCYDSVIAFAKRNRKIRFHVKDQLDPSIAQSIALSTYGMGVLSLHEGVLAKAEKLFKDSITMAKETEFNELLAEAEKELEKTTVLKAAKKEGLN
SIO_010081: YMR115W
subclass of: SO_0000673
so part of: YMR115W
location: 497704..499209
location: region:497704-499209:1
so has part: feature:497704-499209:1:exon

NP_013833.1
type: Protein
SIO_000068: ncbiprotein

S000004721
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:497704-499209:1:exon

YMR116C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASU9
alternative label: CPC2
alternative label: NAD1
gene: ASC1
locus tag: YMR116C
gene synonym: ASU9; CPC2; NAD1
so part of: sequence
location: complement(<499456..>500688)
location: region:499456-500688:-1
so has part: feature:499456-500688:-1:exon
subclass of: SO_0000010

855143
type: Gene
SIO_000068: ncbigene

position:499456:-1
position: 499456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:500688:-1
position: 500688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499456-500688:-1:exon

YMR116C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASU9
alternative label: CPC2
alternative label: NAD1
gene: ASC1
locus tag: YMR116C
gene synonym: ASU9; CPC2; NAD1
product: guanine nucleotide-binding protein subunit beta
transcript id: NM_001182616.1
SIO_010081: YMR116C
subclass of: SO_0000673
so part of: YMR116C
location: complement(join(<499456..499878,500152..>500688))
location: region:499456-500688:-1
so has part: feature:500152-500688:-1:exon
so has part: feature:499456-499878:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:500152-500688:-1:exon

position:500152:-1
position: 500152
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:499456-499878:-1:exon

position:499878:-1
position: 499878
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YMR116C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASU9
alternative label: CPC2
alternative label: NAD1
gene: ASC1
locus tag: YMR116C
gene synonym: ASU9; CPC2; NAD1
experiment: EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:17591772]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:15340087]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27821475]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:17591772]
experiment: EXISTENCE:mutant phenotype:GO:0001934 positive regulation of protein phosphorylation [PMID:27821475]
experiment: EXISTENCE:mutant phenotype:GO:0006521 regulation of cellular amino acid metabolic process [PMID:34214075]
experiment: EXISTENCE:mutant phenotype:GO:0007186 G protein-coupled receptor signaling pathway [PMID:17591772]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:31689955]
experiment: EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:31532761]
experiment: EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:15340087]
experiment: EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:31532761]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:28956756]
experiment: EXISTENCE:mutant phenotype:GO:0080135 regulation of cellular response to stress [PMID:31689955]
experiment: EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:17591772]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]
experiment: EXISTENCE:mutant phenotype:GO:2001125 negative regulation of translational frameshifting [PMID:25792604]
experiment: EXISTENCE:physical interaction:GO:0001965 G-protein alpha-subunit binding [PMID:17591772]
experiment: EXISTENCE:physical interaction:GO:0007186 G protein-coupled receptor signaling pathway [PMID:17591772]
experiment: EXISTENCE:physical interaction:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:17591772]
note: G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins
codon start: 1
product: guanine nucleotide-binding protein subunit beta
translation: MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN
SIO_010081: YMR116C
subclass of: SO_0000673
so part of: YMR116C
location: complement(join(499456..499878,500152..500688))
location: region:499456-500688:-1
so has part: feature:500152-500688:-1:exon
so has part: feature:499456-499878:-1:exon

NP_013834.1
type: Protein
SIO_000068: ncbiprotein

S000004722
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:500152-500688:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:499456-499878:-1:exon

YNCM0026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR24
locus tag: YNCM0026C
so part of: sequence
location: complement(499984..500072)
location: region:499984-500072:-1
so has part: feature:499984-500072:-1:exon
subclass of: SO_0000578

9164952
type: Gene
SIO_000068: ncbigene

position:499984:-1
position: 499984
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:500072:-1
position: 500072
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499984-500072:-1:exon

YNCM0026C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR24
locus tag: YNCM0026C
product: SNR24
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:8674114]
experiment: EXISTENCE:direct assay:GO:0031428 box C/D RNP complex [PMID:10094313]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:8674114]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:8674114]
experiment: EXISTENCE:physical interaction:GO:0031428 box C/D RNP complex [PMID:10733567]
note: C/D box small nucleolar RNA (snoRNA); commonly referred to as U24; guides 2'-O-methylation of large subunit (LSU) rRNA at positions C1437, C1449, and C1450
transcript id: NR_132244.1
SIO_010081: YNCM0026C
subclass of: SO_0000673
so part of: YNCM0026C
location: complement(499984..500072)
location: region:499984-500072:-1
so has part: feature:499984-500072:-1:exon

S000007501
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499984-500072:-1:exon

YMR117C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC24
locus tag: YMR117C
so part of: sequence
location: complement(<501250..>501891)
location: region:501250-501891:-1
so has part: feature:501250-501891:-1:exon
subclass of: SO_0000010

855144
type: Gene
SIO_000068: ncbigene

position:501250:-1
position: 501250
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:501891:-1
position: 501891
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501250-501891:-1:exon

YMR117C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC24
locus tag: YMR117C
product: kinetochore-associated Ndc80 complex subunit SPC24
transcript id: NM_001182617.1
SIO_010081: YMR117C
subclass of: SO_0000673
so part of: YMR117C
location: complement(<501250..>501891)
location: region:501250-501891:-1
so has part: feature:501250-501891:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501250-501891:-1:exon

YMR117C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC24
locus tag: YMR117C
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11179222|PMID:11266451]
experiment: EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11266451]
experiment: EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:11179222]
note: Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p
codon start: 1
product: kinetochore-associated Ndc80 complex subunit SPC24
translation: MSQKDNLLDNPVEFLKEVRESFDIQQDVDAMKRIRHDLDVIKEESEARISKEHSKVSESNKKLNAERINVAKLEGDLEYTNEESNEFGSKDELVKLLKDLDGLERNIVSLRSELDEKMKLYLKDSEIISTPNGSKIKAKVIEPELEEQSAVTPEANENILKLKLYRSLGVILDLENDQVLINRKNDGNIDILPLDNNLSDFYKTKYIWERLGK
SIO_010081: YMR117C
subclass of: SO_0000673
so part of: YMR117C
location: complement(501250..501891)
location: region:501250-501891:-1
so has part: feature:501250-501891:-1:exon

NP_013835.1
type: Protein
SIO_000068: ncbiprotein

S000004723
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501250-501891:-1:exon

YMR118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHH3
locus tag: YMR118C
so part of: sequence
location: complement(<502144..>502734)
location: region:502144-502734:-1
so has part: feature:502144-502734:-1:exon
subclass of: SO_0000010

855145
type: Gene
SIO_000068: ncbigene

position:502144:-1
position: 502144
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502734:-1
position: 502734
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:502144-502734:-1:exon

YMR118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHH3
locus tag: YMR118C
product: protein SHH3
transcript id: NM_001182618.1
SIO_010081: YMR118C
subclass of: SO_0000673
so part of: YMR118C
location: complement(<502144..>502734)
location: region:502144-502734:-1
so has part: feature:502144-502734:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:502144-502734:-1:exon

YMR118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHH3
locus tag: YMR118C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
note: Putative mitochondrial inner membrane hypothetical protein; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication
codon start: 1
product: protein SHH3
translation: MKATIQRVTSVFGVPRASVFVPRISTPFILHNYISNGRMDLFSKEFHNGRVSKSDLWSSNKEEELLVSQRKKRPISPHLTVYEPEMSWYLSSLHRISGVLLALGFYAFTITLGVTTIMGMDTTFQDLNKWYHEKMPKWSQWVAKGSAAYLFAFHFGNGIRHLIWDMGYELTNRGVIKTGSIVLAGTLVLGTYLLAQ
SIO_010081: YMR118C
subclass of: SO_0000673
so part of: YMR118C
location: complement(502144..502734)
location: region:502144-502734:-1
so has part: feature:502144-502734:-1:exon

NP_013836.1
type: Protein
SIO_000068: ncbiprotein

S000004724
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:502144-502734:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 503192..503389
location: region:503192-503389:1
so has part: feature:503192-503389:1:region

S000007123
type: SGD
SIO_000068: sgd

position:503192:1
position: 503192
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:503389:1
position: 503389
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503192-503389:1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1319; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 503389..503771
location: region:503389-503771:1
so has part: feature:503389-503771:1:region

S000130189
type: SGD
SIO_000068: sgd

position:503771:1
position: 503771
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503389-503771:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 503771..504141
location: region:503771-504141:1
so has part: feature:503771-504141:1:region

S000007128
type: SGD
SIO_000068: sgd

position:504141:1
position: 504141
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503771-504141:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 504346..504677
location: region:504346-504677:1
so has part: feature:504346-504677:1:region

S000007124
type: SGD
SIO_000068: sgd

position:504346:1
position: 504346
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:504677:1
position: 504677
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504346-504677:1:region

YNCM0027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0027W
so part of: sequence
location: 504895..505008
location: region:504895-505008:1
so has part: feature:504895-505008:1:exon
subclass of: SO_0000663

855146
type: Gene
SIO_000068: ncbigene

position:504895:1
position: 504895
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:505008:1
position: 505008
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504895-505008:1:exon

YNCM0027W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0027W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0027W
subclass of: SO_0000673
so part of: YNCM0027W
location: join(504895..504932,504965..505008)
location: region:504895-505008:1
so has part: feature:504895-504932:1:exon
so has part: feature:504965-505008:1:exon

S000006644
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:504895-504932:1:exon

position:504932:1
position: 504932
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:504965-505008:1:exon

position:504965:1
position: 504965
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASI1
locus tag: YMR119W
so part of: sequence
location: <505333..>507207
location: region:505333-507207:1
so has part: feature:505333-507207:1:exon
subclass of: SO_0000010

855147
type: Gene
SIO_000068: ncbigene

position:505333:1
position: 505333
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507207:1
position: 507207
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:505333-507207:1:exon

YMR119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASI1
locus tag: YMR119W
product: putative ubiquitin-protein ligase ASI1
transcript id: NM_001182619.1
SIO_010081: YMR119W
subclass of: SO_0000673
so part of: YMR119W
location: <505333..>507207
location: region:505333-507207:1
so has part: feature:505333-507207:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:505333-507207:1:exon

YMR119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASI1
locus tag: YMR119W
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:16735580|PMID:27831485]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]
experiment: EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11454748]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:25236469]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]
experiment: EXISTENCE:mutant phenotype:GO:0036369 transcription factor catabolic process [PMID:25253722]
experiment: EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]
note: Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids
codon start: 1
product: putative ubiquitin-protein ligase ASI1
translation: MNSSTSSENVFINSFSYLNQTSQAVISGNSTFANVINFPYRLGLSFIGAVNLQYEQTVKSEEIPPTLRSVFDTIGFFFSPYAIFCFVIAIVLNRFVVFYAVLNNGSRRTLPLWLSNVFHVSAVVVLAMVSLGPLTLGKDFKILGDPAFAQEKFLLNIFYAFAYSYCVETIFTIMRNSSPLEGTDYSLFELSIQFYTMTNNNTKFLDSPDYIIDCSMAILSRILIHLVEIFRLRNYRLLFSTIMNLCHICYLGIRVKQGGWKSLPFSVKFRHFPKLFSVSIICLSLLIFKLSCLIRWDPFGKSRNSCELLQFYPLSRNWKKYLNYTGEEDFSAMATKFALLLCSGTELMEKGIRREFPAINIPDNVNEKFFISGYLNELSKPYKENTSISFPKKNSSILKQRFFLMFPKSIIWIMKKLVGQVFFGFRDNKDEDIPDNDPSKMLKITKTNSLNNSAGHKEDIELELLNTSDDEYSEDYEPSEVESLGDSDEENLEEDSLIFNETRDALLDLFSSEDNEVHTDYNWIMSTSRILQQKLLSDKTLTRASILDTKLSEVDETFGTESDFDLSCAVCKVNERNTVLWPCRCFAICEDCRISLGLRGFSTCVCCRSKVHGYCKVHPVSDSK
SIO_010081: YMR119W
subclass of: SO_0000673
so part of: YMR119W
location: 505333..507207
location: region:505333-507207:1
so has part: feature:505333-507207:1:exon

NP_013837.1
type: Protein
SIO_000068: ncbiprotein

S000004725
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:505333-507207:1:exon

YMR120C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADE17
locus tag: YMR120C
so part of: sequence
location: complement(<507502..>509280)
location: region:507502-509280:-1
so has part: feature:507502-509280:-1:exon
subclass of: SO_0000010

855149
type: Gene
SIO_000068: ncbigene

position:507502:-1
position: 507502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:509280:-1
position: 509280
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:507502-509280:-1:exon

YMR120C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADE17
locus tag: YMR120C
product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
transcript id: NM_001182621.1
SIO_010081: YMR120C
subclass of: SO_0000673
so part of: YMR120C
location: complement(<507502..>509280)
location: region:507502-509280:-1
so has part: feature:507502-509280:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:507502-509280:-1:exon

YMR120C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADE17
locus tag: YMR120C
EC number: 2.1.2.3
EC number: 3.5.4.10
experiment: EXISTENCE:direct assay:GO:0003937 IMP cyclohydrolase activity [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]
experiment: EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]
experiment: EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]
note: Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
codon start: 1
product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
translation: MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH
SIO_010081: YMR120C
subclass of: SO_0000673
so part of: YMR120C
location: complement(507502..509280)
location: region:507502-509280:-1
so has part: feature:507502-509280:-1:exon

NP_013839.1
type: Protein
SIO_000068: ncbiprotein

S000004727
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:507502-509280:-1:exon

YMR121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL15B
locus tag: YMR121C
so part of: sequence
location: complement(<509734..>510348)
location: region:509734-510348:-1
so has part: feature:509734-510348:-1:exon
subclass of: SO_0000010

855150
type: Gene
SIO_000068: ncbigene

position:509734:-1
position: 509734
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:510348:-1
position: 510348
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:509734-510348:-1:exon

YMR121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL15B
locus tag: YMR121C
product: ribosomal 60S subunit protein L15B
transcript id: NM_001182622.1
SIO_010081: YMR121C
subclass of: SO_0000673
so part of: YMR121C
location: complement(<509734..>510348)
location: region:509734-510348:-1
so has part: feature:509734-510348:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:509734-510348:-1:exon

YMR121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL15B
locus tag: YMR121C
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
codon start: 1
product: ribosomal 60S subunit protein L15B
translation: MGAYKYLEELERKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICNPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK
SIO_010081: YMR121C
subclass of: SO_0000673
so part of: YMR121C
location: complement(509734..510348)
location: region:509734-510348:-1
so has part: feature:509734-510348:-1:exon

NP_013840.1
type: Protein
SIO_000068: ncbiprotein

S000004728
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:509734-510348:-1:exon

YMR122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR122C
so part of: sequence
location: complement(<510701..>511075)
location: region:510701-511075:-1
so has part: feature:510701-511075:-1:exon
subclass of: SO_0000010

855151
type: Gene
SIO_000068: ncbigene

position:510701:-1
position: 510701
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511075:-1
position: 511075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:510701-511075:-1:exon

YMR122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR122C
product: uncharacterized protein
transcript id: NM_001348867.1
SIO_010081: YMR122C
subclass of: SO_0000673
so part of: YMR122C
location: complement(<510701..>511075)
location: region:510701-511075:-1
so has part: feature:510701-511075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:510701-511075:-1:exon

YMR122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR122C
note: hypothetical protein; conserved among S. cerevisiae strains; YMR122C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MLRQFGGVFRNLRVPERTNALLFAQHKGDERHSGQRAFDGSKFRLEAKRCFTAICIITVARRDRLGVLVCGKNTASTLPYLPANRIFRLPKVQIRKMFPIGCATFLSREYIITALLVSYCHLCV
SIO_010081: YMR122C
subclass of: SO_0000673
so part of: YMR122C
location: complement(510701..511075)
location: region:510701-511075:-1
so has part: feature:510701-511075:-1:exon

NP_001335807.1
type: Protein
SIO_000068: ncbiprotein

S000004729
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:510701-511075:-1:exon

YMR122W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NCW1
locus tag: YMR122W-A
so part of: sequence
location: <511315..>511569
location: region:511315-511569:1
so has part: feature:511315-511569:1:exon
subclass of: SO_0000010

855152
type: Gene
SIO_000068: ncbigene

position:511315:1
position: 511315
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511569:1
position: 511569
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:511315-511569:1:exon

YMR122W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NCW1
locus tag: YMR122W-A
product: Ncw1p
transcript id: NM_001184445.1
SIO_010081: YMR122W-A
subclass of: SO_0000673
so part of: YMR122W-A
location: <511315..>511569
location: region:511315-511569:1
so has part: feature:511315-511569:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:511315-511569:1:exon

YMR122W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NCW1
locus tag: YMR122W-A
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
codon start: 1
product: Ncw1p
translation: MASSTSTSASASSSIKTNSALVSNNVVAASSVSATSTASSSAAKNTTSSSKNAAPGMVANPVSSKYGIIMAAFAAVSFVLGTGI
SIO_010081: YMR122W-A
subclass of: SO_0000673
so part of: YMR122W-A
location: 511315..511569
location: region:511315-511569:1
so has part: feature:511315-511569:1:exon

NP_061493.1
type: Protein
SIO_000068: ncbiprotein

S000007524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:511315-511569:1:exon

YMR123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PKR1
locus tag: YMR123W
so part of: sequence
location: <513593..>513961
location: region:513593-513961:1
so has part: feature:513593-513961:1:exon
subclass of: SO_0000010

855153
type: Gene
SIO_000068: ncbigene

position:513593:1
position: 513593
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:513961:1
position: 513961
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513593-513961:1:exon

YMR123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PKR1
locus tag: YMR123W
product: Pkr1p
transcript id: NM_001182624.1
SIO_010081: YMR123W
subclass of: SO_0000673
so part of: YMR123W
location: <513593..>513961
location: region:513593-513961:1
so has part: feature:513593-513961:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:513593-513961:1:exon

YMR123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PKR1
locus tag: YMR123W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16926153]
experiment: EXISTENCE:genetic interaction:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:16926153]
experiment: EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:16926153]
note: V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
codon start: 1
product: Pkr1p
translation: MANFFVRLWESVFEPGTSPQLIIATHVSFVALLLTLIWLIYATNGNIHFYALFCISLLLWITVIWFINELSHVKLKDNDELDKDANKKDDSAIKEDSEDKQESGKSTSTARRTQAQSRSRKA
SIO_010081: YMR123W
subclass of: SO_0000673
so part of: YMR123W
location: 513593..513961
location: region:513593-513961:1
so has part: feature:513593-513961:1:exon

NP_013842.1
type: Protein
SIO_000068: ncbiprotein

S000004730
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:513593-513961:1:exon

YMR124W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EPO1
locus tag: YMR124W
so part of: sequence
location: <514456..>517287
location: region:514456-517287:1
so has part: feature:514456-517287:1:exon
subclass of: SO_0000010

855154
type: Gene
SIO_000068: ncbigene

position:514456:1
position: 514456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:517287:1
position: 517287
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:514456-517287:1:exon

YMR124W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EPO1
locus tag: YMR124W
product: Epo1p
transcript id: NM_001182625.1
SIO_010081: YMR124W
subclass of: SO_0000673
so part of: YMR124W
location: <514456..>517287
location: region:514456-517287:1
so has part: feature:514456-517287:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:514456-517287:1:exon

YMR124W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EPO1
locus tag: YMR124W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]
experiment: EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]
note: Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication
codon start: 1
product: Epo1p
translation: MDAGLSTMATRNGQSSARVKLRNNLLNNDIGNIDIRDETPISRNGNDSNINIQPSSVPQQQQQQQQYYRNGMNEAPIQAPLQQRQIPMQNYSQQQRQQQQYNFEYSNPHMNEIPLMQHNFTKPSLSNNRDNVNGKKASSFTQSSFSNFFKHKHQFGKSKKNTKGTGGGGDGDDDDEVILDDSANSDLTFNDIQTFGHKGGDKYGYGGDSTPIIPTLVTKDRGNMSNTEYRKYITNQRKTAMNAMAKQTKNGTLASLPPRAMSLQSFPNGNPLMQAPTPHPRFQPNKMVSANYSRSNSLMSGPPGQFRQPQQQRMLPMNNYNNHPGQFQNTPPVMPSGQQPPQQPRTLSLTNGPRYSPQNPRPFAGHQQISQRQQQQQQQLQLHPMSEGYRTMSLQSQNVPQGFNPWSPNDNDRKAVSMKQPISQSSISSKNNSAYSIPNVQNNSLTTFSPSSPTDATAMPNSTKQGSSPLKKQVNIDQPIENKGKLNVLQLSTPQQNELKEKERKLAEMEKSLREREALVEEKEKERAEKNTEANEEEEISHESDDLNLRPASALETGLKDLKLESESAVANRASLSTFSSTFSDSPSKQRIINTRTGMYKLENSTDINEYVTAQEFPSPGKYNSNSDNGEMNTTNEVDFDFNTSKRASLLQSIPERDPKRNVSDATIKRRESDGNGRRLSNVNISMNQENINNDTFLYKKNNRDGHLSAVSHMSSSSRRSFISNTLPLNIDSASESDNFVPHMDGSPSKTKSAPVSYDKDGMNASEEDFSFDNTLAKPYEPLYARRGDITSAGSTSGEDSSQPKMITISGEQLNLITENKELMNELTLVSTELAESIKRETELEERIRLYETNNSAPSFDDSSSVSFSDFEKELRKKSSKIVQLIQQLNDERLKRFIAEEQLLLQENGTKPSSMELVGRIENLNKLIDERDSEIEMLKGRLQ
SIO_010081: YMR124W
subclass of: SO_0000673
so part of: YMR124W
location: 514456..517287
location: region:514456-517287:1
so has part: feature:514456-517287:1:exon

NP_013843.1
type: Protein
SIO_000068: ncbiprotein

S000004731
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:514456-517287:1:exon

YMR125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CBC1
alternative label: CBP80
alternative label: GCR3
alternative label: SUT1
gene: STO1
locus tag: YMR125W
gene synonym: CBC1; CBP80; GCR3; SUT1
so part of: sequence
location: <517539..>520446
location: region:517539-520446:1
so has part: feature:517539-520446:1:exon
subclass of: SO_0000010

855155
type: Gene
SIO_000068: ncbigene

position:517539:1
position: 517539
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520446:1
position: 520446
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517539-520446:1:exon

YMR125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CBC1
alternative label: CBP80
alternative label: GCR3
alternative label: SUT1
gene: STO1
locus tag: YMR125W
gene synonym: CBC1; CBP80; GCR3; SUT1
product: Sto1p
transcript id: NM_001182626.1
SIO_010081: YMR125W
subclass of: SO_0000673
so part of: YMR125W
location: join(<517539..517563,517886..>520446)
location: region:517539-520446:1
so has part: feature:517539-517563:1:exon
so has part: feature:517886-520446:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517539-517563:1:exon

position:517563:1
position: 517563
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:517886-520446:1:exon

position:517886:1
position: 517886
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CBC1
alternative label: CBP80
alternative label: GCR3
alternative label: SUT1
gene: STO1
locus tag: YMR125W
gene synonym: CBC1; CBP80; GCR3; SUT1
experiment: EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:15753296]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:22072789]
experiment: EXISTENCE:direct assay:GO:0005846 nuclear cap binding complex [PMID:8811086]
experiment: EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:22072789]
experiment: EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]
note: Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
codon start: 1
product: Sto1p
translation: MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV
SIO_010081: YMR125W
subclass of: SO_0000673
so part of: YMR125W
location: join(517539..517563,517886..520446)
location: region:517539-520446:1
so has part: feature:517539-517563:1:exon
so has part: feature:517886-520446:1:exon

NP_013844.2
type: Protein
SIO_000068: ncbiprotein

S000004732
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517539-517563:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:517886-520446:1:exon

YMR126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DLT1
locus tag: YMR126C
so part of: sequence
location: complement(<520761..>521789)
location: region:520761-521789:-1
so has part: feature:520761-521789:-1:exon
subclass of: SO_0000010

855156
type: Gene
SIO_000068: ncbigene

position:520761:-1
position: 520761
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:521789:-1
position: 521789
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520761-521789:-1:exon

YMR126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DLT1
locus tag: YMR126C
product: Dlt1p
transcript id: NM_001182627.1
SIO_010081: YMR126C
subclass of: SO_0000673
so part of: YMR126C
location: complement(<520761..>521789)
location: region:520761-521789:-1
so has part: feature:520761-521789:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:520761-521789:-1:exon

YMR126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DLT1
locus tag: YMR126C
note: hypothetical protein; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
codon start: 1
product: Dlt1p
translation: MSGFAKLKSWLYKASLFVSLILLIGFSVVLPIDSIAQASKSENNAFNTFIVVGALVVFGVFCIFIIIGRMLFHKSCLKDIPRRYIPITPADLPHRSSREAVLQNMERSKELTILLKKPKDPVIHDGLEPPRRCDYPLDEKLFPEYLNYADCIKSLTDRLKYHGLFLNNLDVRMNLEDTFADVVNSQFVNHNANKIQLEKAKEFIDLYETIRFSGKDVTRDQFIKFVKFCLYFGEVSLTRDTSFANLHNFRLNGSSNNIGRTESKYSINPFDENEYAQDDMHYFPEPPTHLVRESSISTVARHVSSGVDLTNSEEHPLDTDSDCNALRLKLSKADSYRSVIRH
SIO_010081: YMR126C
subclass of: SO_0000673
so part of: YMR126C
location: complement(520761..521789)
location: region:520761-521789:-1
so has part: feature:520761-521789:-1:exon

NP_013845.1
type: Protein
SIO_000068: ncbiprotein

S000004733
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520761-521789:-1:exon

YMR127C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KAT8
gene: SAS2
locus tag: YMR127C
gene synonym: KAT8
so part of: sequence
location: complement(<522329..>523345)
location: region:522329-523345:-1
so has part: feature:522329-523345:-1:exon
subclass of: SO_0000010

855157
type: Gene
SIO_000068: ncbigene

position:522329:-1
position: 522329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:523345:-1
position: 523345
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:522329-523345:-1:exon

YMR127C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KAT8
gene: SAS2
locus tag: YMR127C
gene synonym: KAT8
product: histone acetyltransferase
transcript id: NM_001182628.1
SIO_010081: YMR127C
subclass of: SO_0000673
so part of: YMR127C
location: complement(<522329..>523345)
location: region:522329-523345:-1
so has part: feature:522329-523345:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:522329-523345:-1:exon

YMR127C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KAT8
gene: SAS2
locus tag: YMR127C
gene synonym: KAT8
EC number: 2.3.1.48
experiment: EXISTENCE:curator inference:GO:0000781 chromosome, telomeric region [PMID:11731479]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11731479]
experiment: EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:12626510]
experiment: EXISTENCE:direct assay:GO:0016407 acetyltransferase activity [PMID:11731479]
experiment: EXISTENCE:direct assay:GO:0031509 subtelomeric heterochromatin formation [PMID:11731479]
experiment: EXISTENCE:direct assay:GO:0033255 SAS acetyltransferase complex [PMID:12626510]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:27655944]
experiment: EXISTENCE:physical interaction:GO:0033255 SAS acetyltransferase complex [PMID:15788653]
note: Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p
codon start: 1
product: histone acetyltransferase
translation: MARSLSQSLTATTQKLKGKKNGGKGKNKPSAKIKKTQKEMLYGILNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSVSNSQYWLDTLFVCEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGSTKPMGFFSKDLVSYQQNNLACILIFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQILCWHLIEGDLAHYDKVTLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWLKLHGTKRNWFKLKDEYLLIDD
SIO_010081: YMR127C
subclass of: SO_0000673
so part of: YMR127C
location: complement(522329..523345)
location: region:522329-523345:-1
so has part: feature:522329-523345:-1:exon

NP_013846.1
type: Protein
SIO_000068: ncbiprotein

S000004734
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:522329-523345:-1:exon

YMR128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DHR1
gene: ECM16
locus tag: YMR128W
gene synonym: DHR1
so part of: sequence
location: <523696..>527499
location: region:523696-527499:1
so has part: feature:523696-527499:1:exon
subclass of: SO_0000010

855158
type: Gene
SIO_000068: ncbigene

position:523696:1
position: 523696
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:527499:1
position: 527499
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523696-527499:1:exon

YMR128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DHR1
gene: ECM16
locus tag: YMR128W
gene synonym: DHR1
product: ATP-dependent RNA helicase ECM16
transcript id: NM_001182629.1
SIO_010081: YMR128W
subclass of: SO_0000673
so part of: YMR128W
location: <523696..>527499
location: region:523696-527499:1
so has part: feature:523696-527499:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523696-527499:1:exon

YMR128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DHR1
gene: ECM16
locus tag: YMR128W
gene synonym: DHR1
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:10982841]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10982841|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:10982841]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]
note: Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; predominantly nucleolar in distribution; required for 18S rRNA synthesis
codon start: 1
product: ATP-dependent RNA helicase ECM16
translation: MGTYRKRFNEKARSGHMAKLKELKRIRNKQFTRQDENDERVENPDSAPAESSTTEPNANAEILEPLTEEEKKMKKRKLQELFTPKESKVSRLKKKRLDKFIEHQLKREERKTIIGKLQDYKIDTSLLTSSKRLGEGRQTKKEEFKEALSLERQGRGNEQTNEILYEEYEPKVWDEYGEGGSSEDDDGEDDFEASFGSMPKPTDNEEKKSSGFIDHRPAKFGGSGLSFGFSNIKVINKESKTPKKKYNWRQRVEMEELKKHGKEDEMDFDTTSEDDDEEEDQEEEDKMHPSENPLEEVESADSETGSEKFDQNDVANEFKDWANQEIKKLEGRDQELVTPTLNIDYKPIIRKEDLDDGLQEAYVPINENSTRKAFYVEVSRSDEIQKARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRVAAVSMAERVANELGDHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTLFPIAPPVLQVDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGNSGNGEDEEDEEEEGFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFLRGKLMEEIVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSDIPSVIQIKLLKQMICAGFVDHVAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLGEMPPKYMLYYSLHLGGNNKTRMNTLCDIASTPLANIARKGLLLTYSKPLTGQGLKTVNLSPTERYCYVVPRFGSTVDNDLKIGWDLNPIAVHQKKQKGQWTVIKFITRKGFQTITGEEKEKK
SIO_010081: YMR128W
subclass of: SO_0000673
so part of: YMR128W
location: 523696..527499
location: region:523696-527499:1
so has part: feature:523696-527499:1:exon

NP_013847.1
type: Protein
SIO_000068: ncbiprotein

S000004735
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523696-527499:1:exon

YMR129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POM152
locus tag: YMR129W
so part of: sequence
location: <527804..>531817
location: region:527804-531817:1
so has part: feature:527804-531817:1:exon
subclass of: SO_0000010

855159
type: Gene
SIO_000068: ncbigene

position:527804:1
position: 527804
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:531817:1
position: 531817
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:527804-531817:1:exon

YMR129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POM152
locus tag: YMR129W
product: Pom152p
transcript id: NM_001182630.1
SIO_010081: YMR129W
subclass of: SO_0000673
so part of: YMR129W
location: <527804..>531817
location: region:527804-531817:1
so has part: feature:527804-531817:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:527804-531817:1:exon

YMR129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POM152
locus tag: YMR129W
experiment: EXISTENCE:curator inference:GO:0006913 nucleocytoplasmic transport [PMID:8138573]
experiment: EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:9988776]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:7559775|PMID:8138573|PMID:9988776]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:7559775]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043495 protein-membrane adaptor activity [PMID:7559775]
experiment: EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:10684247|PMID:7559775|PMID:19414609]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16682526]
experiment: EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:20713690]
experiment: EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]
note: Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; type II transmembrane protein composed of N-terminal cytosolic and C-terminal nuclear envelope lumenal domains; homologous to human NUP210
codon start: 1
product: Pom152p
translation: MEHRYNVFNDTPRGNHWMGSSVSGSPRPSYSSRPNVNTTRRFQYSDDEPAEKIRPLRSRSFKSTESNISDEKSRISERDSKDRYINGDKKVDIYSLPLISTDVLEISKQRTFAVILFLIIQCYKIYDLVILKSGLPLSGLLFKNYRFNFISKYFIIDSFFLYVLPSFNIPRLTFKPWVVYLQILAMLLLNIFISSDHEFVLISLIMTTWRKLYTKELSVTGSAINHHRIFDSSAHFKGALTIKILPENTAMFNPLHESYCLPMDTNLFKINSIDVPIRINSTEEIEYIELEYRDLYTNSVELRSLSKKDFKIIDNPKSFLKKDQSVLKSHSNDFEEGSTIRYLAVTLQDIGFYQIKKIVDSKKLNLKIHQSHLVVPYCPIASITGTGSNDRCIGDSDNVSFEIQGVPPMKLAYSKIVNGQTFSYVDSSLQPEYFESPLQSSKSKQSFTQGELNDLKWGRNQPVNINLDSSITQDGKFAYKIDKITDGLGNVVDFTSLPEELKKRYDLSYNFNVHEVPRAALEERFDPKSPTKRSIAIVFEEIKNWISDIPYVISLSYTDAQDKSKKIMNVTTDSLTKVLQADLPGSYNLEYIESKFCPGEIVGKSNVLVTMPVAPTMEVKSFPILDQCVGQVGLNFELSFTGAPPYYYNTKIYKLENGERKLYDAKRYTSEGTRNRFSYSPPKEGNYEIVFDTVSNKLFTEPIKLEPVKEYTFKTSMRVKPSASLKLHHDLKLCLGDHSSVPVALKGQGPFTLTYDIIETFSSKRKTFEIKEIKTNEYVIKTPVFTTGGDYILSLVSIKDSTGCVVGLSQPDAKIQVRRDIPSAAFNFFEPIKEAKIKHGSVTEIPLKLSGEGPFTVKFKHMDYDGNIVKEFENKFQNSYKPALKVSKEGLYQLVDIRDSSCQGNVIYRNSLYKVSFLEKPKFAIQDNHHITKVTENLFSKEEVCQGMEGTVDLALFGSPPFILEYDLMAPNGHISTKKIQVATKYASLKLPNQIPGEYITTIKAIFDGNYGESDIHFREHQSELIIKQTVHPIPDVAFADGGKTLRACAANVDQISFLEPINLKFLQGESPFSITFSVYHESTSRTDQYTIDNIDSENFSFEKLYEGMKLGNHAITIDSVVDANGCVNSLISGPRNQILVSITDAPKIHILDPSTEYCVGDYVAYQLNGVAPFMIKYEFNGIPLKSKERSSQFVRLASEPGIISITSLQDSSSQCIVDFTNPKLKSEFDDLSLNIHPIPSVTVSQGNYVTEDIREGDQAEVIFSFEGTPPFSLTYVRTEETDGKHGKRRSQVVETHKVTDIYSHEYKVITSLQGTYEAIEITDAYCFAKNDLFFNN
SIO_010081: YMR129W
subclass of: SO_0000673
so part of: YMR129W
location: 527804..531817
location: region:527804-531817:1
so has part: feature:527804-531817:1:exon

NP_013848.1
type: Protein
SIO_000068: ncbiprotein

S000004736
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:527804-531817:1:exon

YMR130W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPI35
locus tag: YMR130W
so part of: sequence
location: <532119..>533027
location: region:532119-533027:1
so has part: feature:532119-533027:1:exon
subclass of: SO_0000010

855160
type: Gene
SIO_000068: ncbigene

position:532119:1
position: 532119
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:533027:1
position: 533027
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:532119-533027:1:exon

YMR130W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPI35
locus tag: YMR130W
product: Dpi35p
transcript id: NM_001182631.1
SIO_010081: YMR130W
subclass of: SO_0000673
so part of: YMR130W
location: <532119..>533027
location: region:532119-533027:1
so has part: feature:532119-533027:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:532119-533027:1:exon

YMR130W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPI35
locus tag: YMR130W
note: Putative mitochondrial hypothetical protein; DPI35 is not an essential gene
codon start: 1
product: Dpi35p
translation: MTYPKRIPINAWSEVHRVARPLIITFDAYNTLYATKLPVMEQYCIVGRKYGIKANPSTLTNNFPHVFKKLKEDYPQYGKYSGIKPEQWWSILIRNVFAPNEIPDEMINEILMRFEGFDSYFVYPDLIKFLKDLKSRHPDVILGIVSNTDPIFYKLLKNIGLFETFSGHIYLSYELNLAKPDRAIFQYALDDIISKQPHLLEKYTREEILQHCFHIGDELKNDLEGAEAAGWTGILLDRNDKYGFLSNSISKPMRDEYKLSIDKIDNNSINTWEANTKQTDTLQLSERKYVVSNLEVLEELFP
SIO_010081: YMR130W
subclass of: SO_0000673
so part of: YMR130W
location: 532119..533027
location: region:532119-533027:1
so has part: feature:532119-533027:1:exon

NP_013849.1
type: Protein
SIO_000068: ncbiprotein

S000004737
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:532119-533027:1:exon

YMR131C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRB1
locus tag: YMR131C
so part of: sequence
location: complement(<533163..>534698)
location: region:533163-534698:-1
so has part: feature:533163-534698:-1:exon
subclass of: SO_0000010

855161
type: Gene
SIO_000068: ncbigene

position:533163:-1
position: 533163
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:534698:-1
position: 534698
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:533163-534698:-1:exon

YMR131C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRB1
locus tag: YMR131C
product: ribosome biosynthesis protein RRB1
transcript id: NM_001182632.1
SIO_010081: YMR131C
subclass of: SO_0000673
so part of: YMR131C
location: complement(<533163..>534698)
location: region:533163-534698:-1
so has part: feature:533163-534698:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:533163-534698:-1:exon

YMR131C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRB1
locus tag: YMR131C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:11728313]
note: Specific assembly chaperone for ribosomal protein Rpl3p; co-translationally associates with nascent Rpl3p, preventing aggregation, and facilitating nuclear import; required for biogenesis of preribosomal particles; essential gene; contains five WD-repeat motifs
codon start: 1
product: ribosome biosynthesis protein RRB1
translation: MSKRSIEVNEEQDRVVSAKTESHSVPAIPASEEQDAPKNDLEEQLSDEFDSDGEIIEIDGDDEINDEDDLRKKQEEAETLVQKDQSEGNKEKIQELYLPHMSRPLGPDEVLEADPTVYEMLHNVNMPWPCLTLDVIPDTLGSERRNYPQSILLTTATQSSRKKENELMVLALSNLAKTLLKDDNEGEDDEEDDEDDVDPVIENENIPLRDTTNRLKVSPFAISNQEVLTATMSENGDVYIYNLAPQSKAFSTPGYQIPKSAKRPIHTVKNHGNVEGYGLDWSPLIKTGALLSGDCSGQIYFTQRHTSRWVTDKQPFTVSNNKSIEDIQWSRTESTVFATAGCDGYIRIWDTRSKKHKPAISVKASNTDVNVISWSDKIGYLLASGDDNGTWGVWDLRQFTPSNADAVQPVAQYDFHKGAITSIAFNPLDESIVAVGSEDNTVTLWDLSVEADDEEIKQQAAETKELQEIPPQLLFVHWQKEVKDVKWHKQIPGCLVSTGTDGLNVWKTISV
SIO_010081: YMR131C
subclass of: SO_0000673
so part of: YMR131C
location: complement(533163..534698)
location: region:533163-534698:-1
so has part: feature:533163-534698:-1:exon

NP_013850.1
type: Protein
SIO_000068: ncbiprotein

S000004738
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:533163-534698:-1:exon

YMR132C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: JLP2
locus tag: YMR132C
so part of: sequence
location: complement(<534944..>535570)
location: region:534944-535570:-1
so has part: feature:534944-535570:-1:exon
subclass of: SO_0000010

855162
type: Gene
SIO_000068: ncbigene

position:534944:-1
position: 534944
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:535570:-1
position: 535570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:534944-535570:-1:exon

YMR132C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: JLP2
locus tag: YMR132C
product: Jlp2p
transcript id: NM_001182633.1
SIO_010081: YMR132C
subclass of: SO_0000673
so part of: YMR132C
location: complement(<534944..>535570)
location: region:534944-535570:-1
so has part: feature:534944-535570:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:534944-535570:-1:exon

YMR132C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: JLP2
locus tag: YMR132C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
codon start: 1
product: Jlp2p
translation: MVYFYESKPTEYSTPYQIVMGKDKFENDLLIKWSYRELNYVWFHADKYSSGHVYLKLRPNEKTIDDIPQEVICDCLQLCKSESIQGNKMPQCTILITPWHNLRKNRYMNPGEVSFKSLRQCRKMECGARDNKILNRLAKTRVELFNNVEATLNEAKKTKNGDFFVNYIESNRSNLIEEEKLRKVAKKNQKKKNKQSKDEVTDDMQLEV
SIO_010081: YMR132C
subclass of: SO_0000673
so part of: YMR132C
location: complement(534944..535570)
location: region:534944-535570:-1
so has part: feature:534944-535570:-1:exon

NP_013851.1
type: Protein
SIO_000068: ncbiprotein

S000004739
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:534944-535570:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1320; Autonomously Replicating Sequence
so part of: sequence
location: 535597..535844
location: region:535597-535844:1
so has part: feature:535597-535844:1:region

S000118373
type: SGD
SIO_000068: sgd

position:535597:1
position: 535597
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:535844:1
position: 535844
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535597-535844:1:region

YMR133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: REC114
locus tag: YMR133W
so part of: sequence
location: <536207..>537609
location: region:536207-537609:1
so has part: feature:536207-537609:1:exon
subclass of: SO_0000010

855163
type: Gene
SIO_000068: ncbigene

position:536207:1
position: 536207
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:537609:1
position: 537609
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:536207-537609:1:exon

YMR133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: REC114
locus tag: YMR133W
product: Rec114p
transcript id: NM_001182634.1
SIO_010081: YMR133W
subclass of: SO_0000673
so part of: YMR133W
location: join(<536207..537448,537565..>537609)
location: region:536207-537609:1
so has part: feature:536207-537448:1:exon
so has part: feature:537565-537609:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:536207-537448:1:exon

position:537448:1
position: 537448
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:537565-537609:1:exon

position:537565:1
position: 537565
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: REC114
locus tag: YMR133W
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16783010|PMID:17558514]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8417989]
note: Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
codon start: 1
product: Rec114p
translation: MYEYCSVVIKKYSKYTIPSFAPNGFQSMLEPPQIDKWQHLSANCTLQFRVLLMDSRQILINVVLNNSTLLENIRLPLGDNQDLIQFSCKSPIISCKYISEEFGPRMLRRFQMNLPNDVEFNRTVVSLKNLNFVLRTARTSIAQSTITSQVQGNNNGTKVCFTEGPKVSSYTNPNTQFQTQNMIMDFSQRYQEESERESNNRSNITLPHDSIQIAQQIWPNTDLNVVQSSQDLNTPMATQTVLGRPESLIVQPLEVSQSPPNTTNCLPNAENKKKKVDTTSDFTSRKEIALCKTGLLETIHIPKERESQMQSVTGLDATPTIIWSPGKDNTAKKNTSNKKNIDDKLTNPQKSGNTHTPDRNKEVLPNGTLNETRKEASPSEGLTIRVKNVNRNASRKISKRLIKEKLKDEEFMKWVNKVETVLNKMFEK
SIO_010081: YMR133W
subclass of: SO_0000673
so part of: YMR133W
location: join(536207..537448,537565..537609)
location: region:536207-537609:1
so has part: feature:536207-537448:1:exon
so has part: feature:537565-537609:1:exon

NP_013852.1
type: Protein
SIO_000068: ncbiprotein

S000004740
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:536207-537448:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:537565-537609:1:exon

YMR134W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG29
locus tag: YMR134W
so part of: sequence
location: <537838..>538551
location: region:537838-538551:1
so has part: feature:537838-538551:1:exon
subclass of: SO_0000010

855164
type: Gene
SIO_000068: ncbigene

position:537838:1
position: 537838
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538551:1
position: 538551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:537838-538551:1:exon

YMR134W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG29
locus tag: YMR134W
product: Erg29p
transcript id: NM_001182635.1
SIO_010081: YMR134W
subclass of: SO_0000673
so part of: YMR134W
location: <537838..>538551
location: region:537838-538551:1
so has part: feature:537838-538551:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:537838-538551:1:exon

YMR134W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG29
locus tag: YMR134W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:14690591|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:23892078|PMID:29773647]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:9180083]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:16135527]
note: hypothetical protein involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes
codon start: 1
product: Erg29p
translation: MSLKDRYLNLELKLINKLQELPYVHQFIHDRISGRITLFLIVVGTLAFFNELYITIEMSLLQKNTSEELERGRIDESLKLHRMLVSDEYHGKEYKDEKSGIVIEEFEDRDKFFAKPVFVSELDVECNVIVDGKELLSTPLKFHVEFSPEDYENEKRPEFGTTLRVLRLRLYHYFKDCEIYRDIIKNEGGEGARKFTISNGVKIYNHKDELLPLNIDDVQLCFLKIDTGNTIKCEFIL
SIO_010081: YMR134W
subclass of: SO_0000673
so part of: YMR134W
location: 537838..538551
location: region:537838-538551:1
so has part: feature:537838-538551:1:exon

NP_013853.1
type: Protein
SIO_000068: ncbiprotein

S000004741
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:537838-538551:1:exon

YMR135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DCR1
gene: GID8
locus tag: YMR135C
gene synonym: DCR1
so part of: sequence
location: complement(<538689..>540056)
location: region:538689-540056:-1
so has part: feature:538689-540056:-1:exon
subclass of: SO_0000010

855166
type: Gene
SIO_000068: ncbigene

position:538689:-1
position: 538689
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540056:-1
position: 540056
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538689-540056:-1:exon

YMR135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DCR1
gene: GID8
locus tag: YMR135C
gene synonym: DCR1
product: glucose-induced degradation complex subunit GID8
transcript id: NM_001182636.1
SIO_010081: YMR135C
subclass of: SO_0000673
so part of: YMR135C
location: complement(<538689..>540056)
location: region:538689-540056:-1
so has part: feature:538689-540056:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538689-540056:-1:exon

YMR135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DCR1
gene: GID8
locus tag: YMR135C
gene synonym: DCR1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0034657 GID complex [PMID:16872538|PMID:18508925]
experiment: EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:15590836]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]
experiment: EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]
note: Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
codon start: 1
product: glucose-induced degradation complex subunit GID8
translation: MTISTLSNETTKSGSCSGQGKNGGKDFTYGKKCFTKEEWKEQVAKYSAMGELYANKTIHYPLKIQPNSSGGSQDEGFATIQTTPIEPTLPRLLLNYFVSMAYEDSSIRMAKELGFIRNNKDIAVFNDLYKIKERFHIKHLIKLGRINEAMEEINSIFGLEVLEETFNATGSYTGRTDRQQQQQQQQFDIDGDLHFKLLLLNLIEMIRSHHQQENITKDSNDFILNLIQYSQNKLAIKASSSVKKMQELELAMTLLLFPLSDSADSGSIKLPKSLQNLYSISLRSKIADLVNEKLLKFIHPRIQFEISNNNSKFPDLLNSDKKIITQNFTVYNNNLVNGSNGTKITHISSDQPINEKMSSNEVTAAANSVWLNQRDGNVGTGSAATTFHNLENKNYWNQTSELLSSSNGKEKGLEFNNYYSSEFPYEPRLTQIMKLWCWCENQLHHNQIGVPRVEN
SIO_010081: YMR135C
subclass of: SO_0000673
so part of: YMR135C
location: complement(538689..540056)
location: region:538689-540056:-1
so has part: feature:538689-540056:-1:exon

NP_013854.1
type: Protein
SIO_000068: ncbiprotein

S000004742
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538689-540056:-1:exon

YMR136W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAT2
locus tag: YMR136W
so part of: sequence
location: <541199..>542881
location: region:541199-542881:1
so has part: feature:541199-542881:1:exon
subclass of: SO_0000010

855167
type: Gene
SIO_000068: ncbigene

position:541199:1
position: 541199
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:542881:1
position: 542881
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541199-542881:1:exon

YMR136W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAT2
locus tag: YMR136W
product: Gat2p
transcript id: NM_001182638.1
SIO_010081: YMR136W
subclass of: SO_0000673
so part of: YMR136W
location: <541199..>542881
location: region:541199-542881:1
so has part: feature:541199-542881:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:541199-542881:1:exon

YMR136W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAT2
locus tag: YMR136W
note: Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
codon start: 1
product: Gat2p
translation: MQAPNIYPFSQTQPQALPGFTYGPPQLVFDHSAPRVDPLHSTVTINSPLPLQHYNGPNAHINSANNNYAYYYHHPNNNDNNNHSNNTIKNNNINSVLPAVNIQISNNSHYRNTHQIPSAPQRLVSIIPDPHMPPNISHFQLNNIHPQMHAPVATDIHFQQVPVYNKTNNGIGTDNINNDKPVNSNQNEVLDNIDERSCHEINRVVSFSKHFENNELTTTANDLNIQSTMDELAKLKSLSNSTHFRQSIATQNFHSLQNHITTIENRLASLLTDRQQEQQQLKQQESEKESSSPFSNKIKLPSLQELTDSISTQHLPTFYDNKRHASDTDLKSSTLHGPLYHRHAFLSTSSSSPSPTAGSAPLQKLQVPRQDDPNDKKMNISSSPFNSITYIPNTTLSPMVQTQLKNLTTSNLNTKKKNNRGRPRAIQRQPTLTTSSHFINNSNPGAAAVSTTTPAANSDEKNPNAKKIIEFCFHCGETETPEWRKGPYGTRTLCNACGLFYRKVTKKFGSKSSNLLLRYRRSIDLANDRRIPDFITIPNRFIHDMDNDQTLDSEYNTILQ
SIO_010081: YMR136W
subclass of: SO_0000673
so part of: YMR136W
location: 541199..542881
location: region:541199-542881:1
so has part: feature:541199-542881:1:exon

NP_013856.1
type: Protein
SIO_000068: ncbiprotein

S000004744
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541199-542881:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1321; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 542881..542978
location: region:542881-542978:1
so has part: feature:542881-542978:1:region

S000130190
type: SGD
SIO_000068: sgd

position:542978:1
position: 542978
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542881-542978:1:region

YMR137C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SNM1
gene: PSO2
locus tag: YMR137C
gene synonym: SNM1
so part of: sequence
location: complement(<542978..>544963)
location: region:542978-544963:-1
so has part: feature:542978-544963:-1:exon
subclass of: SO_0000010

855168
type: Gene
SIO_000068: ncbigene

position:542978:-1
position: 542978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:544963:-1
position: 544963
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542978-544963:-1:exon

YMR137C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SNM1
gene: PSO2
locus tag: YMR137C
gene synonym: SNM1
product: DNA cross-link repair protein PSO2
transcript id: NM_001182639.1
SIO_010081: YMR137C
subclass of: SO_0000673
so part of: YMR137C
location: complement(<542978..>544963)
location: region:542978-544963:-1
so has part: feature:542978-544963:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:542978-544963:-1:exon

YMR137C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SNM1
gene: PSO2
locus tag: YMR137C
gene synonym: SNM1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:35482533]
experiment: EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:15590324|PMID:35482533]
experiment: EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]
experiment: EXISTENCE:mutant phenotype:GO:0003684 damaged DNA binding [PMID:7035927]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1736091|PMID:35482533]
experiment: EXISTENCE:mutant phenotype:GO:0008409 5'-3' exonuclease activity [PMID:15590324]
experiment: EXISTENCE:mutant phenotype:GO:0036297 interstrand cross-link repair [PMID:22912599]
note: Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; translocates to mitochondria under genotoxic agents
codon start: 1
product: DNA cross-link repair protein PSO2
translation: MSRKSIVQIRRSEVKRKRSSTASSTSEGKTLHKNTHTSSKRQRTLTEFNIPTSSNLPVRSSSYSFSRFSCSTSNKNTEPVIINDDDHNSICLEDTAKVEITIDTDEEELVSLHDNEVSAIENRTEDRIVTELEEQVNVKVSTEVIQCPICLENLSHLELYERETHCDTCIGSDPSNMGTPKKNIRSFISNPSSPAKTKRDIATSKKPTRVKLVLPSFKIIKFNNGHEIVVDGFNYKASETISQYFLSHFHSDHYIGLKKSWNNPDENPIKKTLYCSKITAILVNLKFKIPMDEIQILPMNKRFWITDTISVVTLDANHCPGAIIMLFQEFLANSYDKPIRQILHTGDFRSNAKMIETIQKWLAETANETIDQVYLDTTYMTMGYNFPSQHSVCETVADFTLRLIKHGKNKTFGDSQRNLFHFQRKKTLTTHRYRVLFLVGTYTIGKEKLAIKICEFLKTKLFVMPNSVKFSMMLTVLQNNENQNDMWDESLLTSNLHESSVHLVPIRVLKSQETIEAYLKSLKELETDYVKDIEDVVGFIPTGWSHNFGLKYQKKNDDDENEMSGNTEYCLELMKNDRDNDDENGFEISSILRQYKKYNKFQVFNVPYSEHSSFNDLVKFGCKLKCSEVIPTVNLNNLWKVRYMTNWFQCWENVRKTRAAK
SIO_010081: YMR137C
subclass of: SO_0000673
so part of: YMR137C
location: complement(542978..544963)
location: region:542978-544963:-1
so has part: feature:542978-544963:-1:exon

NP_013857.1
type: Protein
SIO_000068: ncbiprotein

S000004745
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:542978-544963:-1:exon

YMR138W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GTP1
alternative label: UGX1
gene: CIN4
locus tag: YMR138W
gene synonym: GTP1; UGX1
so part of: sequence
location: <545155..>545730
location: region:545155-545730:1
so has part: feature:545155-545730:1:exon
subclass of: SO_0000010

855169
type: Gene
SIO_000068: ncbigene

position:545155:1
position: 545155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:545730:1
position: 545730
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545155-545730:1:exon

YMR138W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GTP1
alternative label: UGX1
gene: CIN4
locus tag: YMR138W
gene synonym: GTP1; UGX1
product: Arf family GTPase CIN4
transcript id: NM_001182640.1
SIO_010081: YMR138W
subclass of: SO_0000673
so part of: YMR138W
location: <545155..>545730
location: region:545155-545730:1
so has part: feature:545155-545730:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:545155-545730:1:exon

YMR138W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GTP1
alternative label: UGX1
gene: CIN4
locus tag: YMR138W
gene synonym: GTP1; UGX1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:2407611]
experiment: EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]
note: GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
codon start: 1
product: Arf family GTPase CIN4
translation: MGLLSIIRKQKLRDKEIRCLILGLDNSGKSTIVNKLLPKDEQNNDGIMPTVGFQIHSLMIKDVTISLWDIGGQRTLRPFWDNYFDKTQAMIWCIDVSLSMRFDETLQELKELINRDENRIGYECAVIVVLNKIDLVEDKSELHRRCLLVESELKCLFKPDIRIELVKCSGVTGEGIDNLRDRLVESCHFTQ
SIO_010081: YMR138W
subclass of: SO_0000673
so part of: YMR138W
location: 545155..545730
location: region:545155-545730:1
so has part: feature:545155-545730:1:exon

NP_013858.1
type: Protein
SIO_000068: ncbiprotein

S000004746
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545155-545730:1:exon

YMR139W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GSK3
alternative label: MDS1
gene: RIM11
locus tag: YMR139W
gene synonym: GSK3; MDS1
so part of: sequence
location: <546125..>547237
location: region:546125-547237:1
so has part: feature:546125-547237:1:exon
subclass of: SO_0000010

855170
type: Gene
SIO_000068: ncbigene

position:546125:1
position: 546125
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547237:1
position: 547237
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546125-547237:1:exon

YMR139W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GSK3
alternative label: MDS1
gene: RIM11
locus tag: YMR139W
gene synonym: GSK3; MDS1
product: serine/threonine protein kinase RIM11
transcript id: NM_001182641.1
SIO_010081: YMR139W
subclass of: SO_0000673
so part of: YMR139W
location: <546125..>547237
location: region:546125-547237:1
so has part: feature:546125-547237:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546125-547237:1:exon

YMR139W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GSK3
alternative label: MDS1
gene: RIM11
locus tag: YMR139W
gene synonym: GSK3; MDS1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:9372955]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10679022]
note: Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase RIM11
translation: MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDELKLDDGKINQITTDLKLLEFDENVELGHLSPDELSSVKKKLYPKSK
SIO_010081: YMR139W
subclass of: SO_0000673
so part of: YMR139W
location: 546125..547237
location: region:546125-547237:1
so has part: feature:546125-547237:1:exon

NP_013859.1
type: Protein
SIO_000068: ncbiprotein

S000004747
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546125-547237:1:exon

YMR140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SIP5
locus tag: YMR140W
so part of: sequence
location: <547714..>549183
location: region:547714-549183:1
so has part: feature:547714-549183:1:exon
subclass of: SO_0000010

855171
type: Gene
SIO_000068: ncbigene

position:547714:1
position: 547714
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549183:1
position: 549183
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547714-549183:1:exon

YMR140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SIP5
locus tag: YMR140W
product: Sip5p
transcript id: NM_001182642.1
SIO_010081: YMR140W
subclass of: SO_0000673
so part of: YMR140W
location: <547714..>549183
location: region:547714-549183:1
so has part: feature:547714-549183:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:547714-549183:1:exon

YMR140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SIP5
locus tag: YMR140W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:10628972]
note: hypothetical protein; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: Sip5p
translation: MGNVPGKIDQEDSFNDVRPDSSYNTTSSNSVIKQYDEEASSRVRTRRTTSLVNNILNGNNARTKTGSHLSSTSRRKTSREKELAKEAHAKQLVVRCSETVDGGFLAPFGCYSFEKLDYDATVVKNLIIKRKLAPFYTPLQDFDESWTRDELIKIVDGLPLHDTFDENLEEFEDVPIGNLRKSTFNELIDKSLSKKEQRRMHAKIFRARLYKKRILWQENENETFLERKLEMKRIGSKSSNVEDNTSSQPRKNYHLPSDDLKYTLYKNGSECPICFLYFPGPFNYSKCCQQPICTECFVQIKRADPHFPHDEVDPTEPQTNDSEKDPNLLTSEPANCPYCATASFSITYQPPTNRETGIGGMPADSYVYKDAAISRADGGQPNISAITSDTIRPDWEIKLNKERARLMRRSANATAIHISNRLIDPSHSRRRNTSHSITPIHDESTSASRSPEPTINELEDQMVREAIRLSLEDQDNRKKSKNRNTSLRP
SIO_010081: YMR140W
subclass of: SO_0000673
so part of: YMR140W
location: 547714..549183
location: region:547714-549183:1
so has part: feature:547714-549183:1:exon

NP_013860.1
type: Protein
SIO_000068: ncbiprotein

S000004748
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547714-549183:1:exon

YMR141C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR141C
so part of: sequence
location: complement(<549736..>550044)
location: region:549736-550044:-1
so has part: feature:549736-550044:-1:exon
subclass of: SO_0000010

855172
type: Gene
SIO_000068: ncbigene

position:549736:-1
position: 549736
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550044:-1
position: 550044
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549736-550044:-1:exon

YMR141C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR141C
product: uncharacterized protein
transcript id: NM_001348868.1
SIO_010081: YMR141C
subclass of: SO_0000673
so part of: YMR141C
location: complement(<549736..>550044)
location: region:549736-550044:-1
so has part: feature:549736-550044:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549736-550044:-1:exon

YMR141C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR141C
note: hypothetical protein; conserved among S. cerevisiae strains; YMR141C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSRTDTSEKRKEDFIYVSLNIYLCVRLYIMHLISSNTPKSHCSVRFLCFFLSALAITSNRNFFRPEKMPTRIFCNDTLMVSPKTEKFLERFTNQKLAKLEVR
SIO_010081: YMR141C
subclass of: SO_0000673
so part of: YMR141C
location: complement(549736..550044)
location: region:549736-550044:-1
so has part: feature:549736-550044:-1:exon

NP_001335808.1
type: Protein
SIO_000068: ncbiprotein

S000004749
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549736-550044:-1:exon

YMR142C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL13B
locus tag: YMR142C
so part of: sequence
location: complement(<550206..>551207)
location: region:550206-551207:-1
so has part: feature:550206-551207:-1:exon
subclass of: SO_0000010

855173
type: Gene
SIO_000068: ncbigene

position:550206:-1
position: 550206
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551207:-1
position: 551207
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:550206-551207:-1:exon

YMR142C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL13B
locus tag: YMR142C
product: ribosomal 60S subunit protein L13B
transcript id: NM_001182644.1
SIO_010081: YMR142C
subclass of: SO_0000673
so part of: YMR142C
location: complement(join(<550206..550801,551204..>551207))
location: region:550206-551207:-1
so has part: feature:551204-551207:-1:exon
so has part: feature:550206-550801:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551204-551207:-1:exon

position:551204:-1
position: 551204
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:550206-550801:-1:exon

position:550801:-1
position: 550801
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YMR142C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL13B
locus tag: YMR142C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L13B
translation: MAISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARAARAAKIAPRPLDLLRPVVRAPTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRRQNRNQEIFDANVQRLKEYQSKIIVFPRDGKAPEAEQVLSAAATFPIAQPATDVEARAVQDNGESAFRTLRLARSEKKFRGIREKRAREKAEAEAEKKK
SIO_010081: YMR142C
subclass of: SO_0000673
so part of: YMR142C
location: complement(join(550206..550801,551204..551207))
location: region:550206-551207:-1
so has part: feature:551204-551207:-1:exon
so has part: feature:550206-550801:-1:exon

NP_013862.1
type: Protein
SIO_000068: ncbiprotein

S000004750
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551204-551207:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:550206-550801:-1:exon

YMR143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS16A
locus tag: YMR143W
so part of: sequence
location: <551928..>552903
location: region:551928-552903:1
so has part: feature:551928-552903:1:exon
subclass of: SO_0000010

855174
type: Gene
SIO_000068: ncbigene

position:551928:1
position: 551928
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552903:1
position: 552903
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551928-552903:1:exon

YMR143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS16A
locus tag: YMR143W
product: ribosomal 40S subunit protein S16A
transcript id: NM_001182645.1
SIO_010081: YMR143W
subclass of: SO_0000673
so part of: YMR143W
location: join(<551928..551951,552496..>552903)
location: region:551928-552903:1
so has part: feature:551928-551951:1:exon
so has part: feature:552496-552903:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551928-551951:1:exon

position:551951:1
position: 551951
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:552496-552903:1:exon

position:552496:1
position: 552496
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS16A
locus tag: YMR143W
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
experiment: EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:30481328]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S16A
translation: MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
SIO_010081: YMR143W
subclass of: SO_0000673
so part of: YMR143W
location: join(551928..551951,552496..552903)
location: region:551928-552903:1
so has part: feature:551928-551951:1:exon
so has part: feature:552496-552903:1:exon

NP_013863.2
type: Protein
SIO_000068: ncbiprotein

S000004751
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551928-551951:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:552496-552903:1:exon

YMR144W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FDO1
locus tag: YMR144W
so part of: sequence
location: <553362..>554390
location: region:553362-554390:1
so has part: feature:553362-554390:1:exon
subclass of: SO_0000010

855175
type: Gene
SIO_000068: ncbigene

position:553362:1
position: 553362
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:554390:1
position: 554390
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553362-554390:1:exon

YMR144W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FDO1
locus tag: YMR144W
product: Fdo1p
transcript id: NM_001182646.1
SIO_010081: YMR144W
subclass of: SO_0000673
so part of: YMR144W
location: <553362..>554390
location: region:553362-554390:1
so has part: feature:553362-554390:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:553362-554390:1:exon

YMR144W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FDO1
locus tag: YMR144W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:27257873]
experiment: EXISTENCE:physical interaction:GO:0007535 donor selection [PMID:27257873]
note: Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene
codon start: 1
product: Fdo1p
translation: MEENKLSGNKPIQLATWSNQMGSPENNGNNANNGSDVQNVIQKALGLIRQLNNNGLMSPMEEEHSQPSSSQETLSVDREINEQGRLRLLMQAKDDNTRKEVGTYSSPMDSAYARENMLNVLQSLVTHLNQAVSQIQQLKFKNMILTSNENNIQSRHEVEDNLQKQQFERMKCQFLLERQSLKDQLRKRENKIVKYKQKIIEKNKKLNNLAKVLNQHAISDTSQIDSFSSSVKKTPSSTTTPQEMKSDMLNTLGILATHVLKDEIDDDSGNQTILQLAAGSISNDCNTTELEITCSPEMGRTITHNRPNTKDESIQDSHGNRTLQLPKMKSFSTIDGSIKDIK
SIO_010081: YMR144W
subclass of: SO_0000673
so part of: YMR144W
location: 553362..554390
location: region:553362-554390:1
so has part: feature:553362-554390:1:exon

NP_013864.1
type: Protein
SIO_000068: ncbiprotein

S000004752
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:553362-554390:1:exon

YMR144W
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
gene: FDO1
locus tag: YMR144W
note: ARS1322; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
SIO_010081: YMR144W
subclass of: SO_0000673
so part of: YMR144W
location: 553422..554331
location: region:553422-554331:1
so has part: feature:553422-554331:1:exon

S000130191
type: SGD
SIO_000068: sgd

position:553422:1
position: 553422
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:554331:1
position: 554331
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553422-554331:1:exon

YMR145C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NDH1
gene: NDE1
locus tag: YMR145C
gene synonym: NDH1
so part of: sequence
location: complement(<554793..>556475)
location: region:554793-556475:-1
so has part: feature:554793-556475:-1:exon
subclass of: SO_0000010

855176
type: Gene
SIO_000068: ncbigene

position:554793:-1
position: 554793
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556475:-1
position: 556475
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554793-556475:-1:exon

YMR145C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NDH1
gene: NDE1
locus tag: YMR145C
gene synonym: NDH1
product: NADH-ubiquinone reductase (H(+)-translocating) NDE1
transcript id: NM_001182647.1
SIO_010081: YMR145C
subclass of: SO_0000673
so part of: YMR145C
location: complement(<554793..>556475)
location: region:554793-556475:-1
so has part: feature:554793-556475:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554793-556475:-1:exon

YMR145C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NDH1
gene: NDE1
locus tag: YMR145C
gene synonym: NDH1
EC number: 1.6.5.9
experiment: EXISTENCE:direct assay:GO:0003954 NADH dehydrogenase activity [PMID:9696750|PMID:9733747]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9696750|PMID:9733747|PMID:14576278|PMID:24769239|PMI D:16823961]
experiment: EXISTENCE:direct assay:GO:0006116 NADH oxidation [PMID:12032156]
experiment: EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:31668496]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9696750|PMID:9733747]
experiment: EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:9696750|PMID:9733747]
experiment: EXISTENCE:mutant phenotype:GO:0042981 regulation of apoptotic process [PMID:31668496]
note: Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication
codon start: 1
product: NADH-ubiquinone reductase (H(+)-translocating) NDE1
translation: MIRQSLMKTVWANSSRFSLQSKSGLVKYAKNRSFHAARNLLEDKKVILQKVAPTTGVVAKQSFFKRTGKFTLKALLYSALAGTAYVSYSLYREANPSTQVPQSDTFPNGSKRKTLVILGSGWGSVSLLKNLDTTLYNVVVVSPRNYFLFTPLLPSTPVGTIELKSIVEPVRTIARRSHGEVHYYEAEAYDVDPENKTIKVKSSAKNNDYDLDLKYDYLVVGVGAQPNTFGTPGVYEYSSFLKEISDAQEIRLKIMSSIEKAASLSPKDPERARLLSFVVVGGGPTGVEFAAELRDYVDQDLRKWMPELSKEIKVTLVEALPNILNMFDKYLVDYAQDLFKEEKIDLRLKTMVKKVDATTITAKTGDGDIENIPYGVLVWATGNAPREVSKNLMTKLEEQDSRRGLLIDNKLQLLGAKGSIFAIGDCTFHPGLFPTAQVAHQEGEYLAQYFKKAYKIDQLNWKMTHAKDDSEVARLKNQIVKTQSQIEDFKYNHKGALAYIGSDKAIADLAVGEAKYRLAGSFTFLFWKSAYLAMCLSFRNRVLVAMDWAKVYFLGRDSSI
SIO_010081: YMR145C
subclass of: SO_0000673
so part of: YMR145C
location: complement(554793..556475)
location: region:554793-556475:-1
so has part: feature:554793-556475:-1:exon

NP_013865.1
type: Protein
SIO_000068: ncbiprotein

S000004753
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554793-556475:-1:exon

YMR146C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIF34
locus tag: YMR146C
so part of: sequence
location: complement(<557481..>558524)
location: region:557481-558524:-1
so has part: feature:557481-558524:-1:exon
subclass of: SO_0000010

855177
type: Gene
SIO_000068: ncbigene

position:557481:-1
position: 557481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558524:-1
position: 558524
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557481-558524:-1:exon

YMR146C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIF34
locus tag: YMR146C
product: translation initiation factor eIF3 subunit i
transcript id: NM_001182648.1
SIO_010081: YMR146C
subclass of: SO_0000673
so part of: YMR146C
location: complement(<557481..>558524)
location: region:557481-558524:-1
so has part: feature:557481-558524:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557481-558524:-1:exon

YMR146C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIF34
locus tag: YMR146C
experiment: EXISTENCE:direct assay:GO:0002183 cytoplasmic translational initiation [PMID:7798228]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501]
experiment: EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9671501|PMID:9660829]
experiment: EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0032781 positive regulation of ATP-dependent activity [PMID:29192585]
experiment: EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]
experiment: EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:20679478]
experiment: EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829]
note: eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough
codon start: 1
product: translation initiation factor eIF3 subunit i
translation: MKAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSYFDFKYDVEKAAEAKEHMQEAN
SIO_010081: YMR146C
subclass of: SO_0000673
so part of: YMR146C
location: complement(557481..558524)
location: region:557481-558524:-1
so has part: feature:557481-558524:-1:exon

NP_013866.1
type: Protein
SIO_000068: ncbiprotein

S000004754
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557481-558524:-1:exon

YMR147W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LDO45
locus tag: YMR147W
so part of: sequence
location: <559199..>560812
location: region:559199-560812:1
so has part: feature:559199-560812:1:exon
subclass of: SO_0000010

855178
type: Gene
SIO_000068: ncbigene

position:559199:1
position: 559199
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560812:1
position: 560812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559199-560812:1:exon

YMR147W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LDO45
locus tag: YMR147W
product: Ldo45p
transcript id: NM_001182649.2
SIO_010081: YMR147W
subclass of: SO_0000673
so part of: YMR147W
location: join(<559199..559780,560156..>560812)
location: region:559199-560812:1
so has part: feature:559199-559780:1:exon
so has part: feature:560156-560812:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559199-559780:1:exon

position:559780:1
position: 559780
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:560156-560812:1:exon

position:560156:1
position: 560156
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YMR147W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LDO45
locus tag: YMR147W
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:29187528]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:29187528]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:29187528]
note: hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cell periphery
codon start: 1
product: Ldo45p
translation: MAARNRRKNNKKKSLLVTSAAQEKNATYVLVAEELHKKTIDLNMGTETPLTENHENPIPAKEFKHQQKLEPIDEHDDGEDELSIKFKSMTKSSGPITEAEVQKLLLSYAFTSAAIQEDENEKESRHYPIKPPSPSASSLSAYFQSFVEKCKQVFYNFSLQTVEKLNALQNSLYEVFWIIFIYLNYWFPNVGDYVSNTFGQQDSIIIRISLSKSHFRALREKSSQKVQQAVKNIYFCFQEKPYLTAFKVSFAIGLVIPCSLLFLIMVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
SIO_010081: YMR147W
subclass of: SO_0000673
so part of: YMR147W
location: join(559199..559780,560156..560812)
location: region:559199-560812:1
so has part: feature:559199-559780:1:exon
so has part: feature:560156-560812:1:exon

NP_013867.2
type: Protein
SIO_000068: ncbiprotein

S000004755
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559199-559780:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:560156-560812:1:exon

YMR148W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OSW5
gene: LDO16
locus tag: YMR148W
gene synonym: OSW5
so part of: sequence
location: <560366..>560812
location: region:560366-560812:1
so has part: feature:560366-560812:1:exon
subclass of: SO_0000010

855179
type: Gene
SIO_000068: ncbigene

position:560366:1
position: 560366
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560366-560812:1:exon

YMR148W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OSW5
gene: LDO16
locus tag: YMR148W
gene synonym: OSW5
product: Ldo16p
transcript id: NM_001182650.1
SIO_010081: YMR148W
subclass of: SO_0000673
so part of: YMR148W
location: <560366..>560812
location: region:560366-560812:1
so has part: feature:560366-560812:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560366-560812:1:exon

YMR148W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OSW5
gene: LDO16
locus tag: YMR148W
gene synonym: OSW5
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:29187528]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:29187528]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:19779569]
experiment: EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:29187528]
note: hypothetical protein with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
codon start: 1
product: Ldo16p
translation: MVSTATFFFFVYLTLFVVIGFFSSLFIIPLLGISFVFAIGVVSFGFCSNMSFKMAQLIYVRADAFLKKVLDKMALQTQPAQLQEPQEPLSTLRPVSNPTIPSPLRQTARPSKFVTEEDVIFEPVSAQSAIARSLETTANKAGNKFQLS
SIO_010081: YMR148W
subclass of: SO_0000673
so part of: YMR148W
location: 560366..560812
location: region:560366-560812:1
so has part: feature:560366-560812:1:exon

NP_013868.1
type: Protein
SIO_000068: ncbiprotein

S000004756
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560366-560812:1:exon

YMR149W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SWP1
locus tag: YMR149W
so part of: sequence
location: <560996..>561856
location: region:560996-561856:1
so has part: feature:560996-561856:1:exon
subclass of: SO_0000010

855180
type: Gene
SIO_000068: ncbigene

position:560996:1
position: 560996
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:561856:1
position: 561856
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560996-561856:1:exon

YMR149W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SWP1
locus tag: YMR149W
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
transcript id: NM_001182651.1
SIO_010081: YMR149W
subclass of: SO_0000673
so part of: YMR149W
location: <560996..>561856
location: region:560996-561856:1
so has part: feature:560996-561856:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560996-561856:1:exon

YMR149W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SWP1
locus tag: YMR149W
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:29466327]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:29466327]
experiment: EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:29466327]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum
codon start: 1
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
translation: MQFFKTLAALVSCISFVLAYVAQDVHVSFPSTAGKSRVMIGKVEPRIGIDETVPTTITVEDPNEVIQVNFAIESTNKPFQNTLLIGLPNKNLEMAFEPEIKDNGKLSMYKYRIDLAKLDAALLQEASRSPEPIKATLILASSTAKPKENLFREILQLNLNFDVDHSDSSLVDKFGIKPEIHHIFHAEPKRVAKPIAVIFVLIIFITILSLIVTWLNSCAAAFNNIPTGVTAVYFLGFIATIVGFEVIFARYYLGTSIFETLFSSLYLGAPGLLTSTKFLRSFGQTI
SIO_010081: YMR149W
subclass of: SO_0000673
so part of: YMR149W
location: 560996..561856
location: region:560996-561856:1
so has part: feature:560996-561856:1:exon

NP_013869.1
type: Protein
SIO_000068: ncbiprotein

S000004757
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560996-561856:1:exon

YMR150C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMP1
locus tag: YMR150C
so part of: sequence
location: complement(<561956..>562528)
location: region:561956-562528:-1
so has part: feature:561956-562528:-1:exon
subclass of: SO_0000010

855182
type: Gene
SIO_000068: ncbigene

position:561956:-1
position: 561956
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:562528:-1
position: 562528
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561956-562528:-1:exon

YMR150C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMP1
locus tag: YMR150C
product: endopeptidase catalytic subunit IMP1
transcript id: NM_001182652.1
SIO_010081: YMR150C
subclass of: SO_0000673
so part of: YMR150C
location: complement(<561956..>562528)
location: region:561956-562528:-1
so has part: feature:561956-562528:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:561956-562528:-1:exon

YMR150C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMP1
locus tag: YMR150C
experiment: EXISTENCE:direct assay:GO:0004175 endopeptidase activity [PMID:1991446|PMID:8132591]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:1991446]
experiment: EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:8266095]
note: Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p
codon start: 1
product: endopeptidase catalytic subunit IMP1
translation: MTVGTLPIWSKTFSYAIRSLCFLHIIHMYAYEFTETRGESMLPTLSATNDYVHVLKNFQNGRGIKMGDCIVALKPTDPNHRICKRVTGMPGDLVLVDPSTIVNYVGDVLVDEERFGTYIKVPEGHVWVTGDNLSHSLDSRTYNALPMGLIMGKIVAANNFDKPFWDGSIRNIWGFKWINNTFLDVQAKSN
SIO_010081: YMR150C
subclass of: SO_0000673
so part of: YMR150C
location: complement(561956..562528)
location: region:561956-562528:-1
so has part: feature:561956-562528:-1:exon

NP_013870.1
type: Protein
SIO_000068: ncbiprotein

S000004758
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:561956-562528:-1:exon

YMR152W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YIM1
locus tag: YMR152W
so part of: sequence
location: <563096..>564193
location: region:563096-564193:1
so has part: feature:563096-564193:1:exon
subclass of: SO_0000010

855183
type: Gene
SIO_000068: ncbigene

position:563096:1
position: 563096
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:564193:1
position: 564193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:563096-564193:1:exon

YMR152W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YIM1
locus tag: YMR152W
product: Yim1p
transcript id: NM_001182654.1
SIO_010081: YMR152W
subclass of: SO_0000673
so part of: YMR152W
location: <563096..>564193
location: region:563096-564193:1
so has part: feature:563096-564193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:563096-564193:1:exon

YMR152W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YIM1
locus tag: YMR152W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]
experiment: EXISTENCE:direct assay:GO:0018455 alcohol dehydrogenase [NAD(P)+] activity [PMID:32967812]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:12077312]
note: Aldehyde reductase; involved in detoxification of lignocellulose-derived aldehydes; catalyzes the reduction of furan, aliphatic and aromatic aldehydes using either NADH or NADPH as co-factor; membrane of the quinone oxidoreductase subfamily of the medium-chain dehydrogenase/reductase family; null mutant displays sensitivity to DNA damaging agents; protein abundance increases in response to DNA replication stress
codon start: 1
product: Yim1p
translation: MSDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHAAALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHIYGERGTLTHYLILNPAKDVPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDFKKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVPYDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNNKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPIDSVYEFDQYKEAIDRLMSNRAKGKVVVKMK
SIO_010081: YMR152W
subclass of: SO_0000673
so part of: YMR152W
location: 563096..564193
location: region:563096-564193:1
so has part: feature:563096-564193:1:exon

NP_013872.1
type: Protein
SIO_000068: ncbiprotein

S000004760
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:563096-564193:1:exon

YMR153W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUP53
locus tag: YMR153W
so part of: sequence
location: <564435..>565862
location: region:564435-565862:1
so has part: feature:564435-565862:1:exon
subclass of: SO_0000010

855184
type: Gene
SIO_000068: ncbigene

position:564435:1
position: 564435
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:565862:1
position: 565862
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:564435-565862:1:exon

YMR153W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUP53
locus tag: YMR153W
product: FG-nucleoporin NUP53
transcript id: NM_001182656.1
SIO_010081: YMR153W
subclass of: SO_0000673
so part of: YMR153W
location: <564435..>565862
location: region:564435-565862:1
so has part: feature:564435-565862:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:564435-565862:1:exon

YMR153W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUP53
locus tag: YMR153W
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:17897934]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:11071914|PMID:9864357]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:11071914]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:9864357]
experiment: EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:11071914]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]
experiment: EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11071914]
experiment: EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:14697200]
experiment: EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:12473689]
experiment: EXISTENCE:mutant phenotype:GO:0060188 regulation of protein desumoylation [PMID:17403926]
experiment: EXISTENCE:mutant phenotype:GO:0072417 response to spindle checkpoint signaling [PMID:12473689]
experiment: EXISTENCE:physical interaction:GO:0007088 regulation of mitotic nuclear division [PMID:14697200]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788|PMID:9864357]
experiment: EXISTENCE:physical interaction:GO:0060188 regulation of protein desumoylation [PMID:17403926]
note: FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
codon start: 1
product: FG-nucleoporin NUP53
translation: MADLQKQENSSRFTNVSVIAPESQGQHEQQKQQEQLEQQKQPTGLLKGLNGFPSAPQPLFMEDPPSTVSGELNDNPAWFNNPRKRAIPNSIIKRSNGQSLSPVRSDSADVPAFSNSNGFNNVTFGSKKDPRILKNVSPNDNNSANNNAHSSDLGTVVFDSNEAPPKTSLADWQKEDGIFSSKTDNIEDPNLSSNITFDGKPTATPSPFRPLEKTSRILNFFDKNTKTTPNTASSEASAGSKEGASTNWDDHAIIIFGYPETIANSIILHFANFGEILEDFRVIKDFKKLNSKNMSKSPSLTAQKYPIYTGDGWVKLTYKSELSKSRALQENGIIMNGTLIGCVSYSPAALKQLASLKKSEEIINNKTSSQTSLSSKDLSNYRKTEGIFEKAKAKAVTSKVRNAEFKVSKNSTSFKNPRRLEIKDGRSLFLRNRGKIHSGVLSSIESDLKKREQASKSKKSWLNRLNNWLFGWNDL
SIO_010081: YMR153W
subclass of: SO_0000673
so part of: YMR153W
location: 564435..565862
location: region:564435-565862:1
so has part: feature:564435-565862:1:exon

NP_013873.1
type: Protein
SIO_000068: ncbiprotein

S000004762
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:564435-565862:1:exon

YMR154C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPL1
gene: RIM13
locus tag: YMR154C
gene synonym: CPL1
so part of: sequence
location: complement(<565999..>568182)
location: region:565999-568182:-1
so has part: feature:565999-568182:-1:exon
subclass of: SO_0000010

855186
type: Gene
SIO_000068: ncbigene

position:565999:-1
position: 565999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:568182:-1
position: 568182
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:565999-568182:-1:exon

YMR154C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPL1
gene: RIM13
locus tag: YMR154C
gene synonym: CPL1
product: Rim13p
transcript id: NM_001182657.1
SIO_010081: YMR154C
subclass of: SO_0000673
so part of: YMR154C
location: complement(<565999..>568182)
location: region:565999-568182:-1
so has part: feature:565999-568182:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:565999-568182:-1:exon

YMR154C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPL1
gene: RIM13
locus tag: YMR154C
gene synonym: CPL1
experiment: EXISTENCE:direct assay:GO:0004197 cysteine-type endopeptidase activity [PMID:9928935]
experiment: EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:9928935]
note: Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
codon start: 1
product: Rim13p
translation: MNDWHEFNAAIKSIYCNAEGDSSSIINRLVGLAMKSEDSTFIEAVLVLKENVSKVDKQLRFLWLTSTINSRFYPPIPISEASPVSWNKTEYCAPGTEELQRRYPGRAKLQNEEDYSGGIEQCRDVPDCSLVASLINLRSKNLNLPLIKQISSTKYHVNLSFNGSNKRLVTVDISQIPTSVDGKQLSLKSNDISDKIGELALLLVSKGTYSTDGSNISIDTYRLSGFLPEITQVNSYPFEKLWKFHKSNLCLMGAGTGNRSNDMIKPLVENHDYSIIDITYDSRLVKLRDPRNSALNVEISYEQYLKNFKQLYLNWNQEKLFKRSQVLHFRYDTSRYNKFSIVADKPLFHLVNNSKVTETVWLLLESHLQDEGSQENRSVSFLNEAPECIICPIEPPVECGGNHIGLQLVKLRLDAETERLLYCYSTTNNNFSIHSFSVVKEICFQRLKDTKSLFAKVLFSFPYEIEGKASFDTCNFFQNPTFELEVHSEQDYQVLMDAACISTSSHDLINIQVYYFNDYELIKPIMFDNHYQPGQGLKQDVPILTNVKYMIVCSTYGPPASTEFELLASIRLSSSWRLISGITLRSVNLIYGTYPYHCRNRFHWKETSDKLKIQMTLPTKKYSTNKLFIRVVPVESSARLRMRCNIFEPESALCVYECQEYRTCPSGGIVIPDLEVSRTNIVVLMIERSVPISSCLPTEGQLDELELFVGSSQKIRIEKYSDDVIPK
SIO_010081: YMR154C
subclass of: SO_0000673
so part of: YMR154C
location: complement(565999..568182)
location: region:565999-568182:-1
so has part: feature:565999-568182:-1:exon

NP_013875.1
type: Protein
SIO_000068: ncbiprotein

S000004763
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:565999-568182:-1:exon

YMR155W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR155W
so part of: sequence
location: <568551..>570194
location: region:568551-570194:1
so has part: feature:568551-570194:1:exon
subclass of: SO_0000010

855187
type: Gene
SIO_000068: ncbigene

position:568551:1
position: 568551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:570194:1
position: 570194
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568551-570194:1:exon

YMR155W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR155W
product: uncharacterized protein
transcript id: NM_001182658.1
SIO_010081: YMR155W
subclass of: SO_0000673
so part of: YMR155W
location: <568551..>570194
location: region:568551-570194:1
so has part: feature:568551-570194:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:568551-570194:1:exon

YMR155W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR155W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
codon start: 1
product: uncharacterized protein
translation: MVKKHQNSKMGNTNHFGHLKSFVGGNVVALGAGTPYLFSFYAPQLLSKCHIPVSASSKLSFSLTIGSSLMGILAGIVVDRSPKLSCLIGSMCVFIAYLILNLCYKHEWSSTFLISLSLVLIGYGSVSGFYASVKCANTNFPQHRGTAGAFPVSLYGLSGMVFSYLCSKLFGENIEHVFIFLMVACGCMILVGYFSLDIFSNAEGDDASIKEWELQKSRETDDNIVPLYENSNDYIGSPVRSSSPATYETYALSDNFQETSEFFALEDRQLSNRPLLSPSSPHTKYDFEDENTSKNTVGENSAQKSMRLHVFQSLKSSTFIGYYIVLGILQGVGLMYIYSVGFMVQAQVSTPPLNQLPINAEKIQSLQVTLLSLLSFCGRLSSGPISDFLVKKFKAQRLWNIVIASLLVFLASNKISHDFSSIEDPSLRASKSFKNISVCSAIFGYSFGVLFGTFPSIVADRFGTNGYSTLWGVLTTGGVFSVSVFTDILGRDFKANTGDDDGNCKKGVLCYSYTFMVTKYCAAFNLLFVLGIIGYTYYRRRATANSL
SIO_010081: YMR155W
subclass of: SO_0000673
so part of: YMR155W
location: 568551..570194
location: region:568551-570194:1
so has part: feature:568551-570194:1:exon

NP_013876.1
type: Protein
SIO_000068: ncbiprotein

S000004764
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568551-570194:1:exon

YMR156C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPP1
locus tag: YMR156C
so part of: sequence
location: complement(<570300..>571016)
location: region:570300-571016:-1
so has part: feature:570300-571016:-1:exon
subclass of: SO_0000010

855188
type: Gene
SIO_000068: ncbigene

position:570300:-1
position: 570300
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:571016:-1
position: 571016
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:570300-571016:-1:exon

YMR156C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPP1
locus tag: YMR156C
product: polynucleotide 3'-phosphatase
transcript id: NM_001182659.1
SIO_010081: YMR156C
subclass of: SO_0000673
so part of: YMR156C
location: complement(<570300..>571016)
location: region:570300-571016:-1
so has part: feature:570300-571016:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:570300-571016:-1:exon

YMR156C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPP1
locus tag: YMR156C
EC number: 3.1.3.32
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11278831|PMID:15222769]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15222769]
experiment: EXISTENCE:direct assay:GO:0046403 polynucleotide 3'-phosphatase activity [PMID:11278831]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:11585902]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11585902]
experiment: EXISTENCE:mutant phenotype:GO:0046403 polynucleotide 3'-phosphatase activity [PMID:15222769]
note: DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase
codon start: 1
product: polynucleotide 3'-phosphatase
translation: MSHKLTILPFLIKFTPKFPQSIDHDEHGLNVYAFDLDHTIIKPKSPNISFSRSASDWQFINFNSKKSTLDYLCNIIDNDPTAVIVIFSNQGGVITVPRTSKSCTKYTNKILLFLKAIKNDERGETLSHRLWLYAAPKRPKTFAANHSKITFASLGESYNNDPNIFEKVRKPMTGMVEFFKRDLESAYRVSEQISPIKLNWIYYCGDAAGRKKDFSDSDIKFAENLHVEFKYPEEIFHG
SIO_010081: YMR156C
subclass of: SO_0000673
so part of: YMR156C
location: complement(570300..571016)
location: region:570300-571016:-1
so has part: feature:570300-571016:-1:exon

NP_013877.1
type: Protein
SIO_000068: ncbiprotein

S000004765
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:570300-571016:-1:exon

YMR157C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP39
gene: AIM36
locus tag: YMR157C
gene synonym: FMP39
so part of: sequence
location: complement(<571277..>572044)
location: region:571277-572044:-1
so has part: feature:571277-572044:-1:exon
subclass of: SO_0000010

855189
type: Gene
SIO_000068: ncbigene

position:571277:-1
position: 571277
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:572044:-1
position: 572044
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:571277-572044:-1:exon

YMR157C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP39
gene: AIM36
locus tag: YMR157C
gene synonym: FMP39
product: Aim36p
transcript id: NM_001182660.1
SIO_010081: YMR157C
subclass of: SO_0000673
so part of: YMR157C
location: complement(<571277..>572044)
location: region:571277-572044:-1
so has part: feature:571277-572044:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:571277-572044:-1:exon

YMR157C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP39
gene: AIM36
locus tag: YMR157C
gene synonym: FMP39
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
note: hypothetical protein; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
codon start: 1
product: Aim36p
translation: MLRPLRKSVLASCRHCFKVCGGLPQKQLPLFSPLLLRARYSSTDSSTKRSNKSDKIDAPGFKKIFLVAIIGTVIFVKTVQSLDKNKPKTTLSEEEFENVVKGLKRRVAIFPQGEVDIKFSLSPSIEETRKVLQKSQGDDINELQFVDPVKVIDYYRTLRDDRYEALLNEYYKKYGCDTYAYNLPTGMLVMLLGRYFKENFKTGDKLVVVNFPHSIADATRFENEVSIVSKIFVPRKLSGSDVCKYYETVGKADII
SIO_010081: YMR157C
subclass of: SO_0000673
so part of: YMR157C
location: complement(571277..572044)
location: region:571277-572044:-1
so has part: feature:571277-572044:-1:exon

NP_013878.1
type: Protein
SIO_000068: ncbiprotein

S000004766
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:571277-572044:-1:exon

YMR158W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uS8m
gene: MRPS8
locus tag: YMR158W
gene synonym: uS8m
so part of: sequence
location: <572248..>572715
location: region:572248-572715:1
so has part: feature:572248-572715:1:exon
subclass of: SO_0000010

855190
type: Gene
SIO_000068: ncbigene

position:572248:1
position: 572248
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:572715:1
position: 572715
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:572248-572715:1:exon

YMR158W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uS8m
gene: MRPS8
locus tag: YMR158W
gene synonym: uS8m
product: mitochondrial 37S ribosomal protein MRPS8
transcript id: NM_001182661.1
SIO_010081: YMR158W
subclass of: SO_0000673
so part of: YMR158W
location: <572248..>572715
location: region:572248-572715:1
so has part: feature:572248-572715:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:572248-572715:1:exon

YMR158W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uS8m
gene: MRPS8
locus tag: YMR158W
gene synonym: uS8m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]
note: Mitochondrial ribosomal protein of the small subunit
codon start: 1
product: mitochondrial 37S ribosomal protein MRPS8
translation: MSLVKLANTCAHLQNCSKVRVALTSIPYTKLQLQFAYNLYQQGFLSSLQKGSTMGPDKDFVEVTPDNISTRRLWVGLKYRDNKPVLSSCKLISKPNSRIHLPMEDMKKLCSGVTIRNIKPLQPGELILVRAHNNIMDINEAISKKLDGEVLCRVK
SIO_010081: YMR158W
subclass of: SO_0000673
so part of: YMR158W
location: 572248..572715
location: region:572248-572715:1
so has part: feature:572248-572715:1:exon

NP_013879.1
type: Protein
SIO_000068: ncbiprotein

S000004767
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:572248-572715:1:exon

YNCM0028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMT4
locus tag: YNCM0028C
so part of: sequence
location: complement(572883..572955)
location: region:572883-572955:-1
so has part: feature:572883-572955:-1:exon
subclass of: SO_0000663

855191
type: Gene
SIO_000068: ncbigene

position:572883:-1
position: 572883
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:572955:-1
position: 572955
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:572883-572955:-1:exon

YNCM0028C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: EMT4
locus tag: YNCM0028C
product: tRNA-Met
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Methionine tRNA (tRNA-Met), functions in translational elongation; not involved in translational initiation; predicted by tRNAscan-SE analysis
SIO_010081: YNCM0028C
subclass of: SO_0000673
so part of: YNCM0028C
location: complement(572883..572955)
location: region:572883-572955:-1
so has part: feature:572883-572955:-1:exon

S000006664
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:572883-572955:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(573112..573338)
location: region:573112-573338:-1
so has part: feature:573112-573338:-1:region

S000007116
type: SGD
SIO_000068: sgd

position:573112:-1
position: 573112
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:573338:-1
position: 573338
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:573112-573338:-1:region

YMR158C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YMR158C-B
locus tag: YMR158C-A
gene synonym: YMR158C-B
so part of: sequence
location: complement(<573194..>573331)
location: region:573194-573331:-1
so has part: feature:573194-573331:-1:exon
subclass of: SO_0000010

855192
type: Gene
SIO_000068: ncbigene

position:573194:-1
position: 573194
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573331:-1
position: 573331
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:573194-573331:-1:exon

YMR158C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YMR158C-B
locus tag: YMR158C-A
gene synonym: YMR158C-B
product: uncharacterized protein
transcript id: NM_001184342.1
SIO_010081: YMR158C-A
subclass of: SO_0000673
so part of: YMR158C-A
location: complement(<573194..>573331)
location: region:573194-573331:-1
so has part: feature:573194-573331:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:573194-573331:-1:exon

YMR158C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YMR158C-B
locus tag: YMR158C-A
gene synonym: YMR158C-B
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: hypothetical protein; may contain a lipid attachment site; localizes to cytosol, and to peroxisomes in oleate-growing cells; YMR158C-A is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MKMNYHLSTSSYTTSMLSCTVLDDDIRYEKLSWKLDEAEMQGLIM
SIO_010081: YMR158C-A
subclass of: SO_0000673
so part of: YMR158C-A
location: complement(573194..573331)
location: region:573194-573331:-1
so has part: feature:573194-573331:-1:exon

NP_013880.1
type: Protein
SIO_000068: ncbiprotein

S000007249
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:573194-573331:-1:exon

YMR159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG15
alternative label: APG16
alternative label: CVT11
alternative label: SAP18
gene: ATG16
locus tag: YMR159C
gene synonym: APG15; APG16; CVT11; SAP18
so part of: sequence
location: complement(<574476..>574928)
location: region:574476-574928:-1
so has part: feature:574476-574928:-1:exon
subclass of: SO_0000010

855194
type: Gene
SIO_000068: ncbigene

position:574476:-1
position: 574476
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:574928:-1
position: 574928
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574476-574928:-1:exon

YMR159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG15
alternative label: APG16
alternative label: CVT11
alternative label: SAP18
gene: ATG16
locus tag: YMR159C
gene synonym: APG15; APG16; CVT11; SAP18
product: Atg16p
transcript id: NM_001182663.1
SIO_010081: YMR159C
subclass of: SO_0000673
so part of: YMR159C
location: complement(<574476..>574928)
location: region:574476-574928:-1
so has part: feature:574476-574928:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574476-574928:-1:exon

YMR159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG15
alternative label: APG16
alternative label: CVT11
alternative label: SAP18
gene: ATG16
locus tag: YMR159C
gene synonym: APG15; APG16; CVT11; SAP18
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:11689437]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016236 macroautophagy [PMID:11897782]
experiment: EXISTENCE:direct assay:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:11897782]
experiment: EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]
experiment: EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:17192262]
experiment: EXISTENCE:mutant phenotype:GO:0019776 Atg8 ligase activity [PMID:17192262]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11897782]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:17192262]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:mutant phenotype:GO:1905037 autophagosome organization [PMID:24485455]
experiment: EXISTENCE:physical interaction:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:10406794]
note: Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
codon start: 1
product: Atg16p
translation: MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK
SIO_010081: YMR159C
subclass of: SO_0000673
so part of: YMR159C
location: complement(574476..574928)
location: region:574476-574928:-1
so has part: feature:574476-574928:-1:exon

NP_013882.1
type: Protein
SIO_000068: ncbiprotein

S000004769
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574476-574928:-1:exon

YMR160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CVM1
locus tag: YMR160W
so part of: sequence
location: <575066..>577516
location: region:575066-577516:1
so has part: feature:575066-577516:1:exon
subclass of: SO_0000010

855195
type: Gene
SIO_000068: ncbigene

position:575066:1
position: 575066
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:577516:1
position: 577516
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575066-577516:1:exon

YMR160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CVM1
locus tag: YMR160W
product: Cvm1p
transcript id: NM_001182664.1
SIO_010081: YMR160W
subclass of: SO_0000673
so part of: YMR160W
location: <575066..>577516
location: region:575066-577516:1
so has part: feature:575066-577516:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:575066-577516:1:exon

YMR160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CVM1
locus tag: YMR160W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35766971]
experiment: EXISTENCE:direct assay:GO:0098853 endoplasmic reticulum-vacuole membrane contact site [PMID:35766971]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:35766971]
experiment: EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:35766971]
note: Protein involved in sphingolipid metabolism; localizes to vacuolar contact sites with mitochondria, ER and peroxisomes; mutant has enhanced sensitivity to overexpression of mutant huntingtin; relative distribution within the vacuolar membrane changes upon DNA replication stress
codon start: 1
product: Cvm1p
translation: MDVVQQKQDKQLQHQTQEQQQIREDQQEVPPQRPRQQNRWKPWWNSTADDEPNTGRIAEYPNGQGRSSPTTDFQDSVNSNNDNKGIWSKIASFATSRYRSAPIVVDDNTRYSQLNTEQINFLENEAKDIISKKSKSWCWYEAIPHISNSSNIIDSIDTPGIISVSGTGSAKCPLPLNKYPGEGGNPGYNVFINDSLILPSDNPLNFLHVQPLRTKVLNTIKNYYNFPNEQHLYLRQKKTALLKDKRIIIISVVGDLPEKYEQRSLESQRSAYYLSRKLSQNLAQEQPQRVLTLSFQCPLHNQDLIPTYKECVELLNHWAHLFKEVDSIFFVGVYHSVPLTLLLAKYIVQNNEVLEFDENTTVSVLSFQSCLQGYRFWDHSTDFTSNSYNNLGSNSSTNENDSNDHDSNNDFTTKSQQIKEKQLFQGIDKKQQDTLSKIKNYRRIDSSESKLVQDALDWLLFNWDTFRLTFFGKLYDNFMTISEKLAIDYNHPKILRNLWCNGKYMGIDLKNANNLNLDTDDEATSNINDVHVRTPNFESRLKIPTNRLFEITLWDILMITENLGYKQFIPIINLLSPFFISRSFNDYTLPPNIRKQYQNSNKIWLQEMDSKWKMNGHQLNYDQREGESLGSSSESLLPENISTVKDFLQFVQYQNEKSSDFVRIYSDIYDDDKVYKCFLYNTIFTKNPLSRKHLRLNIDLDTPTSILNTVNQYDLVWKIHDSFSKLIQLKNLPQREIPHALRLSISLNCFLDSTTSTSGPVFQRDTVEALRRLTEIWRTYQDWSPPTRGLKHLRDILSVLAMYDNPKNLINDVRRT
SIO_010081: YMR160W
subclass of: SO_0000673
so part of: YMR160W
location: 575066..577516
location: region:575066-577516:1
so has part: feature:575066-577516:1:exon

NP_013883.1
type: Protein
SIO_000068: ncbiprotein

S000004770
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:575066-577516:1:exon

YMR161W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HLJ1
locus tag: YMR161W
so part of: sequence
location: <577718..>578392
location: region:577718-578392:1
so has part: feature:577718-578392:1:exon
subclass of: SO_0000010

855196
type: Gene
SIO_000068: ncbigene

position:577718:1
position: 577718
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:578392:1
position: 578392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:577718-578392:1:exon

YMR161W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HLJ1
locus tag: YMR161W
product: type I HSP40 co-chaperone HLJ1
transcript id: NM_001182665.1
SIO_010081: YMR161W
subclass of: SO_0000673
so part of: YMR161W
location: <577718..>578392
location: region:577718-578392:1
so has part: feature:577718-578392:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:577718-578392:1:exon

YMR161W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HLJ1
locus tag: YMR161W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:15342786]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:15252059|PMID:15342786]
note: Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
codon start: 1
product: type I HSP40 co-chaperone HLJ1
translation: MSFTEDQEKIALEILSKDKHEFYEILKVDRKATDSEIKKAYRKLAIKLHPDKNSHPKAGEAFKVINRAFEVLSNEEKRSIYDRIGRDPDDRQMPSRGAASGFRGSAGGSPMGGGFEDMFFNSRFGGQRAGPPEDIFDFLFNAGGSPFGASPFGPSASTFSFGGPGGFRVYTNNRGGSPFMRQQPRSRQQQQQAEENAVNSQLKNMLVLFIIFIVLPMIKDYLFS
SIO_010081: YMR161W
subclass of: SO_0000673
so part of: YMR161W
location: 577718..578392
location: region:577718-578392:1
so has part: feature:577718-578392:1:exon

NP_013884.1
type: Protein
SIO_000068: ncbiprotein

S000004771
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:577718-578392:1:exon

YMR162C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DNF3
locus tag: YMR162C
so part of: sequence
location: complement(<578951..>583921)
location: region:578951-583921:-1
so has part: feature:578951-583921:-1:exon
subclass of: SO_0000010

855197
type: Gene
SIO_000068: ncbigene

position:578951:-1
position: 578951
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583921:-1
position: 583921
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578951-583921:-1:exon

YMR162C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DNF3
locus tag: YMR162C
product: aminophospholipid-translocating P4-type ATPase DNF3
transcript id: NM_001182666.1
SIO_010081: YMR162C
subclass of: SO_0000673
so part of: YMR162C
location: complement(<578951..>583921)
location: region:578951-583921:-1
so has part: feature:578951-583921:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:578951-583921:-1:exon

YMR162C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DNF3
locus tag: YMR162C
EC number: 7.6.2.1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:17093059]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32661085]
experiment: EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:12221123]
experiment: EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]
experiment: EXISTENCE:genetic interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:25378585]
experiment: EXISTENCE:genetic interaction:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]
experiment: EXISTENCE:genetic interaction:GO:0140345 phosphatidylcholine flippase activity [PMID:16452632]
experiment: EXISTENCE:genetic interaction:GO:0140346 phosphatidylserine flippase activity [PMID:16452632]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:32661085]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:16452632|PMID:32661085]
experiment: EXISTENCE:mutant phenotype:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]
experiment: EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:16452632]
experiment: EXISTENCE:mutant phenotype:GO:0140346 phosphatidylserine flippase activity [PMID:32661085]
note: Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone
codon start: 1
product: aminophospholipid-translocating P4-type ATPase DNF3
translation: MGIADGQRRRSSSLRTQMFNKHLYDKYRGRTDDEIELEDINESKTFSGSDNNDKDDRDETSGNYAAEEDYEMEEYGSPDVSYSIITKILDTILDRRRTFHSKDGRHIPIILDHNAIEYKQAATKRDGHLIDERFNKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMGISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPLNDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGENSECFVETMALDGETNLKSKQPHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKNHRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKINMIIVFMVFVVATISLFSYLGHVLHKKKYIDQNKAWYLFQADAGVAPTIMSFIIMYNTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTDNKMIFRKFSLCGSSWLHNVDLGNSEDNFEDNRDNTNSLRLPPKAHNGSSIDVVSIGDQNVLDRLGFSDAPIEKGHRPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFGKDNSHLSKQASVISPSETFSENIKSSFDLIQFIQRYPTALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIEYQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYIDFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELVLQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLETVKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIGSDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDEAGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYSTVVILTTTDENIISKMNAVSQEVDSGNIAHCVVVIDGATMAMFEGNPTYMSVFVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGLQASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYEPWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFNWLIFMEWVILATTNSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNWLAFTSVVLSCGGWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFWCTSLVLALLPITLDIVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTDKVLSRPRTNSRASAKTHNSSIYSMSNGNVDHSSKKNFFGNSSKKSSERYEVLPSGKLIKRPSLKTQSSKDSIGGNITTKLTKKLKLPSRNVEDEDVNQIIQARLKDLE
SIO_010081: YMR162C
subclass of: SO_0000673
so part of: YMR162C
location: complement(578951..583921)
location: region:578951-583921:-1
so has part: feature:578951-583921:-1:exon

NP_013885.1
type: Protein
SIO_000068: ncbiprotein

S000004772
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578951-583921:-1:exon

YMR163C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INP2
locus tag: YMR163C
so part of: sequence
location: complement(<584271..>586388)
location: region:584271-586388:-1
so has part: feature:584271-586388:-1:exon
subclass of: SO_0000010

855198
type: Gene
SIO_000068: ncbigene

position:584271:-1
position: 584271
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:586388:-1
position: 586388
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584271-586388:-1:exon

YMR163C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INP2
locus tag: YMR163C
product: Inp2p
transcript id: NM_001182667.1
SIO_010081: YMR163C
subclass of: SO_0000673
so part of: YMR163C
location: complement(<584271..>586388)
location: region:584271-586388:-1
so has part: feature:584271-586388:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584271-586388:-1:exon

YMR163C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INP2
locus tag: YMR163C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16678774]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:16678774]
experiment: EXISTENCE:genetic interaction:GO:0045033 peroxisome inheritance [PMID:16678774]
experiment: EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:16678774]
experiment: EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:16678774]
experiment: EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:16678774]
experiment: EXISTENCE:physical interaction:GO:0045033 peroxisome inheritance [PMID:16678774]
note: Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
codon start: 1
product: Inp2p
translation: MTTNSRPSALQAPGLQIFSMLKSSEEDGFMSSSLTLDSDNIIGVTENNRQEFYSTWRKPSLLSSRSVLHEYSPTIVGSNDCTFSPITVGKTTKFFNWDDIISRIFMQQPFGVTHQFFEEFRYSIITSHFLNDMNHYRLSLHLDQSIMNFHKSSTLLKNVPPKSVPFMATKYGKLAVAEDKKLYFRQNFNYLSMIITSYRVLTQLKKYCRKKNSPGLKRVVILILVAVYLSIQQEYFRRHLICYKTLLKVRKVLESLQQVDVMIHKYHLRFKEIKNHSFISRVSLISIADEHSSVIKELLVFSSDALFYKLKSIIPDIVIFSDTSELSKYCELYGIDVPNLYYNNTTTVKDLDGKLYRLKLLKKFMLCCLLSLDMTGNENLSNVNMRNALNKIFPDYMARVQLKKKYNPIGTFQNIVSLLRGLHSLLSTVLVSLNDHKQILYAFPEETSTNTGCERANVCSFSKNDKLFQALNYLKMIENNLLAIDIRNGITENDRNIIEDKLEELITFWKTSKICGNISRIQKVSPTNTINHGFHLDILKGRKSPRSSSVQGLSLERKVDFIDVAESVNDSFENDTELEEYEDYDCQEECSAGSRQNHRVDFIGKDSCRKPDFKQLSDNELRRKLDERILKLAQENREGRERLRTAKSFELLRKAQASMSVKFGFQKPLRDDAFLESRPLSKCKVSSEETIPFLYELKGLLGNDS
SIO_010081: YMR163C
subclass of: SO_0000673
so part of: YMR163C
location: complement(584271..586388)
location: region:584271-586388:-1
so has part: feature:584271-586388:-1:exon

NP_013886.1
type: Protein
SIO_000068: ncbiprotein

S000004773
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584271-586388:-1:exon

YNCM0029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCM0029C
so part of: sequence
location: complement(586636..586709)
location: region:586636-586709:-1
so has part: feature:586636-586709:-1:exon
subclass of: SO_0000663

855199
type: Gene
SIO_000068: ncbigene

position:586636:-1
position: 586636
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:586709:-1
position: 586709
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586636-586709:-1:exon

YNCM0029C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCM0029C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCM0029C
subclass of: SO_0000673
so part of: YNCM0029C
location: complement(586636..586709)
location: region:586636-586709:-1
so has part: feature:586636-586709:-1:exon

S000006765
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586636-586709:-1:exon

YMR164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSS11
locus tag: YMR164C
so part of: sequence
location: complement(<587274..>589550)
location: region:587274-589550:-1
so has part: feature:587274-589550:-1:exon
subclass of: SO_0000010

855200
type: Gene
SIO_000068: ncbigene

position:587274:-1
position: 587274
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:589550:-1
position: 589550
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:587274-589550:-1:exon

YMR164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSS11
locus tag: YMR164C
product: Mss11p
transcript id: NM_001182668.1
SIO_010081: YMR164C
subclass of: SO_0000673
so part of: YMR164C
location: complement(<587274..>589550)
location: region:587274-589550:-1
so has part: feature:587274-589550:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:587274-589550:-1:exon

YMR164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSS11
locus tag: YMR164C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10515942]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10515942|PMID:9987114]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15466424]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15466424|PMID:16568252|PMID:9342405|PMID:9987114]
note: Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1
codon start: 1
product: Mss11p
translation: MDNTTNINTNERSSNTDFSSAPNIKGLNSHTQLQFDADSRVFVSDVMAKNSKQLLYAHIYNYLIKNNYWNSAAKFLSEADLPLSRINGSASGGKTSLNASLKQGLMDIASKGDIVSEDGLLPSKMLMDANDTFLLEWWEIFQSLFNGDLESGYQQDHNPLRERIIPILPANSKSNMPSHFSNLPPNVIPPTQNSFPVSEESFRPNGDGSNFNLNDPTNRNVSERFLSRTSGVYDKQNSANFAPDTAINSDIAGQQYATINLHKHFNDLQSPAQPQQSSQQQIQQPQHQPQHQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQTPYPIVNPQMVPHIPSENSHSTGLMPSVPPTNQQFNAQTQSSMFSDQQRFFQYQLHHQNQGQAPSFQQSQSGRFDDMNAMKMFFQQQALQQNSLQQNLGNQNYQSNTRNNTAEETTPTNDNNANGNSLLQEHIRARFNKMKTIPQQMKNQSTVANPVVSDITSQQQYMHMMMQRMAANQQLQNSAFPPDTNRIAPANNTMPLQPGNMGSPVIENPGMRQTNPSGQNPMINMQPLYQNVSSAMHAFAPQQQFHLPQHYKTNTSVPQNDSTSVFPLPNNNNNNNNNNNNNNNNNSNNSNNNNNNNNNNNNSNNTPTVSQPSSKCTSSSSTTPNITTTIQPKRKQRVGKTKTKESRKVAAAQKVMKSKKLEQNGDSAATNFINVTPKDSGGKGTVKVQNSNSQQQLNGSFSMDTETFDIFNIGDFSPDLMDS
SIO_010081: YMR164C
subclass of: SO_0000673
so part of: YMR164C
location: complement(587274..589550)
location: region:587274-589550:-1
so has part: feature:587274-589550:-1:exon

NP_013887.1
type: Protein
SIO_000068: ncbiprotein

S000004774
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:587274-589550:-1:exon

YMR165C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SMP2
gene: PAH1
locus tag: YMR165C
gene synonym: SMP2
so part of: sequence
location: complement(<590040..>592628)
location: region:590040-592628:-1
so has part: feature:590040-592628:-1:exon
subclass of: SO_0000010

855201
type: Gene
SIO_000068: ncbigene

position:590040:-1
position: 590040
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592628:-1
position: 592628
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:590040-592628:-1:exon

YMR165C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SMP2
gene: PAH1
locus tag: YMR165C
gene synonym: SMP2
product: phosphatidate phosphatase PAH1
transcript id: NM_001182669.1
SIO_010081: YMR165C
subclass of: SO_0000673
so part of: YMR165C
location: complement(<590040..>592628)
location: region:590040-592628:-1
so has part: feature:590040-592628:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:590040-592628:-1:exon

YMR165C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SMP2
gene: PAH1
locus tag: YMR165C
gene synonym: SMP2
EC number: 3.1.3.4
experiment: EXISTENCE:direct assay:GO:0000976 transcription cis-regulatory region binding [PMID:15889145]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005773 vacuole [PMID:22121197]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:26275961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16467296|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:16467296|PMID:35026226]
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:20876142|PMID:35026226]
experiment: EXISTENCE:genetic interaction:GO:0019432 triglyceride biosynthetic process [PMID:24196957]
experiment: EXISTENCE:genetic interaction:GO:0034389 lipid droplet organization [PMID:21829381]
experiment: EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:8437575]
experiment: EXISTENCE:mutant phenotype:GO:0008195 phosphatidate phosphatase activity [PMID:16467296]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:16467296|PMID:17971454|PMID:35026226]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8437575]
experiment: EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:24196957|PMID:35026226]
experiment: EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:21422231]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:22121197]
note: Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null
codon start: 1
product: phosphatidate phosphatase PAH1
translation: MQYVGRALGSVSKTWSSINPATLSGAIDVIVVEHPDGRLSCSPFHVRFGKFQILKPSQKKVQVFINEKLSNMPMKLSDSGEAYFVFEMGDQVTDVPDELLVSPVMSATSSPPQSPETSILEGGTEGEGEGENENKKKEKKVLEEPDFLDINDTGDSGSKNSETTGSLSPTESSTTTPPDSVEERKLVEQRTKNFQQKLNKKLTEIHIPSKLDNNGDLLLDTEGYKPNKNMMHDTDIQLKQLLKDEFGNDSDISSFIKEDKNGNIKIVNPYEHLTDLSPPGTPPTMATSGSVLGLDAMESGSTLNSLSSSPSGSDTEDETSFSKEQSSKSEKTSKKGTAGSGETEKRYIRTIRLTNDQLKCLNLTYGENDLKFSVDHGKAIVTSKLFVWRWDVPIVISDIDGTITKSDALGHVLAMIGKDWTHLGVAKLFSEISRNGYNILYLTARSAGQADSTRSYLRSIEQNGSKLPNGPVILSPDRTMAALRREVILKKPEVFKIACLNDIRSLYFEDSDNEVDTEEKSTPFFAGFGNRITDALSYRTVGIPSSRIFTINTEGEVHMELLELAGYRSSYIHINELVDHFFPPVSLDSVDLRTNTSMVPGSPPNRTLDNFDSEITSGRKTLFRGNQEEKFTDVNFWRDPLVDIDNLSDISNDDSDNIDEDTDVSQQSNISRNRANSVKTAKVTKAPQRNVSGSTNNNEVLAASSDVENASDLVSSHSSSGSTPNKSTMSKGDIGKQIYLELGSPLASPKLRYLDDMDDEDSNYNRTKSRRASSAAATSIDKEFKKLSVSKAGAPTRIVSKINVSNDVHSLGNSDTESRREQSVNETGRNQLPHNSMDDKDLDSRVSDEFDDDEFDEDEFED
SIO_010081: YMR165C
subclass of: SO_0000673
so part of: YMR165C
location: complement(590040..592628)
location: region:590040-592628:-1
so has part: feature:590040-592628:-1:exon

NP_013888.1
type: Protein
SIO_000068: ncbiprotein

S000004775
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:590040-592628:-1:exon

YMR166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MME1
locus tag: YMR166C
so part of: sequence
location: complement(<593367..>594473)
location: region:593367-594473:-1
so has part: feature:593367-594473:-1:exon
subclass of: SO_0000010

855202
type: Gene
SIO_000068: ncbigene

position:593367:-1
position: 593367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:594473:-1
position: 594473
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593367-594473:-1:exon

YMR166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MME1
locus tag: YMR166C
product: Mme1p
transcript id: NM_001182670.1
SIO_010081: YMR166C
subclass of: SO_0000673
so part of: YMR166C
location: complement(<593367..>594473)
location: region:593367-594473:-1
so has part: feature:593367-594473:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593367-594473:-1:exon

YMR166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MME1
locus tag: YMR166C
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:25585246]
experiment: EXISTENCE:direct assay:GO:0015095 magnesium ion transmembrane transporter activity [PMID:25585246]
experiment: EXISTENCE:direct assay:GO:0015693 magnesium ion transport [PMID:25585246]
experiment: EXISTENCE:mutant phenotype:GO:1990616 magnesium ion export from mitochondrion [PMID:25585246]
note: Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers
codon start: 1
product: Mme1p
translation: MNSWNLSSSIPIIHTPHDHPPTSEGTPDQPNNNRKDDKLHKKRGDSDEDLSPIWHCVVSGGIGGKIGDSAMHSLDTVKTRQQGAPNVKKYRNMISAYRTIWLEEGVRRGLYGGYMAAMLGSFPSAAIFFGTYEYTKRTMIEDWQINDTITHLSAGFLGDFISSFVYVPSEVLKTRLQLQGRFNNPFFQSGYNYSNLRNAIKTVIKEEGFRSLFFGYKATLARDLPFSALQFAFYEKFRQLAFKIEQKDGRDGELSIPNEILTGACAGGLAGIITTPMDVVKTRVQTQQPPSQSNKSYSVTHPHVTNGRPAALSNSISLSLRTVYQSEGVLGFFSGVGPRFVWTSVQSSIMLLLYQMTLRGLSNAFPTD
SIO_010081: YMR166C
subclass of: SO_0000673
so part of: YMR166C
location: complement(593367..594473)
location: region:593367-594473:-1
so has part: feature:593367-594473:-1:exon

NP_013889.1
type: Protein
SIO_000068: ncbiprotein

S000004776
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593367-594473:-1:exon

YMR167W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PMS2
gene: MLH1
locus tag: YMR167W
gene synonym: PMS2
so part of: sequence
location: <594886..>597195
location: region:594886-597195:1
so has part: feature:594886-597195:1:exon
subclass of: SO_0000010

855203
type: Gene
SIO_000068: ncbigene

position:594886:1
position: 594886
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:597195:1
position: 597195
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594886-597195:1:exon

YMR167W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PMS2
gene: MLH1
locus tag: YMR167W
gene synonym: PMS2
product: mismatch repair ATPase MLH1
transcript id: NM_001182671.1
SIO_010081: YMR167W
subclass of: SO_0000673
so part of: YMR167W
location: <594886..>597195
location: region:594886-597195:1
so has part: feature:594886-597195:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:594886-597195:1:exon

YMR167W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PMS2
gene: MLH1
locus tag: YMR167W
gene synonym: PMS2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11717305]
experiment: EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432|PMID:23316435]
experiment: EXISTENCE:mutant phenotype:GO:0000713 meiotic heteroduplex formation [PMID:15654114]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10938116]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10570173]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11717305]
experiment: EXISTENCE:physical interaction:GO:0032389 MutLalpha complex [PMID:11237696|PMID:8066446|PMID:10570173]
experiment: EXISTENCE:physical interaction:GO:0032390 MutLbeta complex [PMID:10570173]
experiment: EXISTENCE:physical interaction:GO:0097587 MutLgamma complex [PMID:9770499|PMID:10570173]
note: Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; required for silencing at the silent mating-type loci and telomeres; human homolog is associated with hereditary non-polyposis colon cancer
codon start: 1
product: mismatch repair ATPase MLH1
translation: MSLRIKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSGINKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWRVSYAEGKMLESPKPVAGKDGTTILVEDLFFNIPSRLRALRSHNDEYSKILDVVGRYAIHSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFNKSVASNLITFHISKVEDLNLESVDGKVCNLNFISKKSISPIFFINNRLVTCDLLRRALNSVYSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQLHAELSAIDTSRTFKASSISTNKPESLIPFNDTIESDRNRKSLRQAQVVENSYTTANSQLRKAKRQENKLVRIDASQAKITSFLSSSQQFNFEGSSTKRQLSEPKVTNVSHSQEAEKLTLNESEQPRDANTINDNDLKDQPKKKQKLGDYKVPSIADDEKNALPISKDGYIRVPKERVNVNLTSIKKLREKVDDSIHRELTDIFANLNYVGVVDEERRLAAIQHDLKLFLIDYGSVCYELFYQIGLTDFANFGKINLQSTNVSDDIVLYNLLSEFDELNDDASKEKIISKIWDMSSMLNEYYSIELVNDGLDNDLKSVKLKSLPLLLKGYIPSLVKLPFFIYRLGKEVDWEDEQECLDGILREIALLYIPDMVPKVDTSDASLSEDEKAQFINRKEHISSLLEHVLFPCIKRRFLAPRHILKDVVEIANLPDLYKVFERC
SIO_010081: YMR167W
subclass of: SO_0000673
so part of: YMR167W
location: 594886..597195
location: region:594886-597195:1
so has part: feature:594886-597195:1:exon

NP_013890.1
type: Protein
SIO_000068: ncbiprotein

S000004777
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:594886-597195:1:exon

YMR168C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CBF3
alternative label: CSL1
gene: CEP3
locus tag: YMR168C
gene synonym: CBF3; CSL1
so part of: sequence
location: complement(<597332..>599158)
location: region:597332-599158:-1
so has part: feature:597332-599158:-1:exon
subclass of: SO_0000010

855204
type: Gene
SIO_000068: ncbigene

position:597332:-1
position: 597332
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:599158:-1
position: 599158
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:597332-599158:-1:exon

YMR168C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CBF3
alternative label: CSL1
gene: CEP3
locus tag: YMR168C
gene synonym: CBF3; CSL1
product: Cep3p
transcript id: NM_001182672.1
SIO_010081: YMR168C
subclass of: SO_0000673
so part of: YMR168C
location: complement(<597332..>599158)
location: region:597332-599158:-1
so has part: feature:597332-599158:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:597332-599158:-1:exon

YMR168C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CBF3
alternative label: CSL1
gene: CEP3
locus tag: YMR168C
gene synonym: CBF3; CSL1
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10352012]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10097110]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:10352012]
experiment: EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:1997204|PMID:8670864|PMID:8706132]
experiment: EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:11290706]
note: Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
codon start: 1
product: Cep3p
translation: MFNRTTQLKSKHPCSVCTRRKVKCDRMIPCGNCRKRGQDSECMKSTKLITASSSKEYLPDLLLFWQNYEYWITNIGLYKTKQRDLTRTPANLDTDTEECMFWMNYLQKDQSFQLMNFAMENLGALYFGSIGDISELYLRVEQYWDRRADKNHSVDGKYWDALIWSVFTMCIYYMPVEKLAEIFSVYPLHEYLGSNKRLNWEDGMQLVMCQNFARCSLFQLKQCDFMAHPDIRLVQAYLILATTTFPYDEPLLANSLLTQCIHTFKNFHVDDFRPLLNDDPVESIAKVTLGRIFYRLCGCDYLQSGPRKPIALHTEVSSLLQHAAYLQDLPNVDVYREENSTEVLYWKIISLDRDLDQYLNKSSKPPLKTLDAIRRELDIFQYKVDSLEEDFRSNNSRFQKFIALFQISTVSWKLFKMYLIYYDTADSLLKVIHYSKVIISLIVNNFHAKSEFFNRHPMVMQTITRVVSFISFYQIFVESAAVKQLLVDLTELTANLPTIFGSKLDKLVYLTERLSKLKLLWDKVQLLDSGDSFYHPVFKILQNDIKIIELKNDEMFSLIKGLGSLVPLNKLRQESLLEEEDENNTEPSDFRTIVEEFQSEYNISDILS
SIO_010081: YMR168C
subclass of: SO_0000673
so part of: YMR168C
location: complement(597332..599158)
location: region:597332-599158:-1
so has part: feature:597332-599158:-1:exon

NP_013891.1
type: Protein
SIO_000068: ncbiprotein

S000004778
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:597332-599158:-1:exon

YMR169C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALD3
locus tag: YMR169C
so part of: sequence
location: complement(<599352..>600872)
location: region:599352-600872:-1
so has part: feature:599352-600872:-1:exon
subclass of: SO_0000010

855205
type: Gene
SIO_000068: ncbigene

position:599352:-1
position: 599352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:600872:-1
position: 600872
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599352-600872:-1:exon

YMR169C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALD3
locus tag: YMR169C
product: aldehyde dehydrogenase (NAD(+)) ALD3
transcript id: NM_001182673.1
SIO_010081: YMR169C
subclass of: SO_0000673
so part of: YMR169C
location: complement(<599352..>600872)
location: region:599352-600872:-1
so has part: feature:599352-600872:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:599352-600872:-1:exon

YMR169C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALD3
locus tag: YMR169C
EC number: 1.2.1.3
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:10407263]
experiment: EXISTENCE:mutant phenotype:GO:0006598 polyamine catabolic process [PMID:12586697]
experiment: EXISTENCE:mutant phenotype:GO:0019483 beta-alanine biosynthetic process [PMID:12586697]
note: Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
codon start: 1
product: aldehyde dehydrogenase (NAD(+)) ALD3
translation: MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPFHSNAKQDLAQIIELTRYYAGAVDKFNMGETIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACRKMQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNVIPGYGSVVGKALGTHMDIDKISFTGSTKVGGSVLEASGQSNLKDITLECGGKSPALVFEDADLDKAIEWVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKKEEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPETSKLLRDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINQTNQEEAKVPFGGFKMSGIGRESGDTGVDNYLQIKSVHVDLSLDK
SIO_010081: YMR169C
subclass of: SO_0000673
so part of: YMR169C
location: complement(599352..600872)
location: region:599352-600872:-1
so has part: feature:599352-600872:-1:exon

NP_013892.1
type: Protein
SIO_000068: ncbiprotein

S000004779
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:599352-600872:-1:exon

YMR170C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALD2
locus tag: YMR170C
so part of: sequence
location: complement(<601562..>603082)
location: region:601562-603082:-1
so has part: feature:601562-603082:-1:exon
subclass of: SO_0000010

855206
type: Gene
SIO_000068: ncbigene

position:601562:-1
position: 601562
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:603082:-1
position: 603082
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:601562-603082:-1:exon

YMR170C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALD2
locus tag: YMR170C
product: aldehyde dehydrogenase (NAD(+)) ALD2
transcript id: NM_001182674.1
SIO_010081: YMR170C
subclass of: SO_0000673
so part of: YMR170C
location: complement(<601562..>603082)
location: region:601562-603082:-1
so has part: feature:601562-603082:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:601562-603082:-1:exon

YMR170C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALD2
locus tag: YMR170C
EC number: 1.2.1.3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:12586697]
experiment: EXISTENCE:mutant phenotype:GO:0006598 polyamine catabolic process [PMID:12586697]
experiment: EXISTENCE:mutant phenotype:GO:0019483 beta-alanine biosynthetic process [PMID:12586697]
note: Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
codon start: 1
product: aldehyde dehydrogenase (NAD(+)) ALD2
translation: MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPYHSNAKGDLAQILQLTRYFAGSADKFDKGATIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACWKLQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNIVPGYGSLVGQALASHMDIDKISFTGSTKVGGFVLEASGQSNLKDVTLECGGKSPALVFEDADLDKAIDWIAAGIFYNSGQNCTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKREEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPQTSKLLQDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINSSNDEDVTVPFGGFKMSGIGRELGQSGVDTYLQTKAVHINLSLDN
SIO_010081: YMR170C
subclass of: SO_0000673
so part of: YMR170C
location: complement(601562..603082)
location: region:601562-603082:-1
so has part: feature:601562-603082:-1:exon

NP_013893.1
type: Protein
SIO_000068: ncbiprotein

S000004780
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:601562-603082:-1:exon

YMR171C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EAR1
locus tag: YMR171C
so part of: sequence
location: complement(<603868..>605520)
location: region:603868-605520:-1
so has part: feature:603868-605520:-1:exon
subclass of: SO_0000010

855207
type: Gene
SIO_000068: ncbigene

position:603868:-1
position: 603868
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:605520:-1
position: 605520
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:603868-605520:-1:exon

YMR171C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EAR1
locus tag: YMR171C
product: Ear1p
transcript id: NM_001182675.1
SIO_010081: YMR171C
subclass of: SO_0000673
so part of: YMR171C
location: complement(<603868..>605520)
location: region:603868-605520:-1
so has part: feature:603868-605520:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:603868-605520:-1:exon

YMR171C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EAR1
locus tag: YMR171C
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:18367543|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:18367543|PMID:30361468]
experiment: EXISTENCE:mutant phenotype:GO:1990756 ubiquitin ligase-substrate adaptor activity [PMID:30361468]
note: Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
codon start: 1
product: Ear1p
translation: MSFKFLIESLLLGSISGQIRCGRSSVIPRGDVSYGGDDTDELNMDIMLFAFGTLIVVYIVICIVYFFTKQIATRLITAYYNEHGPGQRISLFSDYDENNAHVHSRRLMENMSLRWPNNLDDADEVRDKLAQLSPEEQFYYKQGEEYIKQNPPFLLNQGLLQQSEDSNPDTTREDPIMNEQTRQYIQEEGAYAWEFSPNPDMPNHTVIVENKTEVSFLNYNYDASISTNLPIPCINKVYYCEFKIFETDGPLNSDENVSKGVISFGLSTQPYPYFRLPGRHHHSIAYDSNGARRFNDSFKLNEQLRTLFPQCEKGDIVGIGYRSRSGTVFFTRNGKKLNEKSVGGHIRGWKFQYLYPIIGSNVPCQIHVNFGTYGFVYIEANVKKWGYAKSNGIKLPPPSYEDYGKDTLLESGGEDNDFDEDFSDGDSDNIAAGSTTNLNDDIIIRNGEILPPPPGFEFTMSPPTGKKIINEEINLDSLPMLPPSYSDDEHHSKNDKSAISGRIIGTSRNLITDEASFDSVDNDNEDENDHERDPEQFSEFDDYESRMHGI
SIO_010081: YMR171C
subclass of: SO_0000673
so part of: YMR171C
location: complement(603868..605520)
location: region:603868-605520:-1
so has part: feature:603868-605520:-1:exon

NP_013894.1
type: Protein
SIO_000068: ncbiprotein

S000004781
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:603868-605520:-1:exon

YMR172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HOT1
locus tag: YMR172W
so part of: sequence
location: <605981..>608140
location: region:605981-608140:1
so has part: feature:605981-608140:1:exon
subclass of: SO_0000010

855208
type: Gene
SIO_000068: ncbigene

position:605981:1
position: 605981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:608140:1
position: 608140
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605981-608140:1:exon

YMR172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HOT1
locus tag: YMR172W
product: Hot1p
transcript id: NM_001182677.1
SIO_010081: YMR172W
subclass of: SO_0000673
so part of: YMR172W
location: <605981..>608140
location: region:605981-608140:1
so has part: feature:605981-608140:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:605981-608140:1:exon

YMR172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HOT1
locus tag: YMR172W
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11336700]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10409737]
experiment: EXISTENCE:direct assay:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:12743037]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12743037]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10722658|PMID:10409737]
experiment: EXISTENCE:mutant phenotype:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:12743037]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10409737|PMID:10722658|PMID:25904326]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12743037]
note: Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
codon start: 1
product: Hot1p
translation: MSGMGIAILCIVRTKIYRITISFDYSTLMSPFFLFLMMPTTLKDGYRMNSQVNEDAIGINLDLSLPTHISPTTGSESASGSNASTLRNDGNALDGGLLRTSAAISAPTGTSQPTETIGEKLSNEERVNSNVSASNSTTAGTGRMLSQSLTNDSPSNEISTDQLKIFQRMDEMSARMIEMEESFNKLSNKIAEQNTMVLNLKQDNYKVMNKLNILLKLVAQPSARPSTNNAQNKLAIELLNSISAVSSAYLQKMQNNGSGRQHTADLCTGDSNTHSGINQHRTTNGTIDVNTNTAQLNNQFSNALNTILPDQQHNRNNVSQNINQSLPNRQLGPVINTQANQNQSQVLIHNTNTHQQVNRSPISFPNASTDKPFKLNPNGIKRRRRNTQSNNNASTNDHASAAQKPISALSPLTNSHNSTTSMNYTNSSIHSGVTSASNSFHDLNSLNNFGTTTALSLPSLALDNASFPPNQNVIPPIINNTQQPLSFSQLINQDSTTSELLPSGKSGVNTNIVNRNRASTLPSYPKPMTVKSNVDDDGYQEDDDDDGDDEGDGRDNEEDSTAEEDEVDDEIETDMKNASINKRRRSLHHKKSNSLNGRRKLHGESATKPNINSDLHYRILKAPTDVKTIWEEYDTGIRGKPSIKHLEAKYGNKWRLNKNKKTFSRRKRLYKFILNGMERGKTAQEMIETLENKRLYKDDEDGEVKKRTIGWLQESLAGI
SIO_010081: YMR172W
subclass of: SO_0000673
so part of: YMR172W
location: 605981..608140
location: region:605981-608140:1
so has part: feature:605981-608140:1:exon

NP_013895.1
type: Protein
SIO_000068: ncbiprotein

S000004783
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605981-608140:1:exon

YMR173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DDR48
locus tag: YMR173W
so part of: sequence
location: <608689..>609981
location: region:608689-609981:1
so has part: feature:608689-609981:1:exon
subclass of: SO_0000010

855210
type: Gene
SIO_000068: ncbigene

position:608689:1
position: 608689
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:609981:1
position: 609981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:608689-609981:1:exon

YMR173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DDR48
locus tag: YMR173W
product: DNA damage-responsive protein 48
transcript id: NM_001182678.1
SIO_010081: YMR173W
subclass of: SO_0000673
so part of: YMR173W
location: <608689..>609981
location: region:608689-609981:1
so has part: feature:608689-609981:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:608689-609981:1:exon

YMR173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DDR48
locus tag: YMR173W
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8444852]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:2111448]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8444852]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:2111448]
note: DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
codon start: 1
product: DNA damage-responsive protein 48
translation: MGLFDKVKQFANSNNNNNDSGNNNQGDYVTKAENMIGEDRVNQFKSKIGEDRFDKMESKVRQQFSNTSINDNDSNNNDSYGSNNNDSYGSNNNDSYGSNNNDSYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNNDSYGSNNNDSYGSNNDDSYGSSNKNKSSYGSNNDDSYGSNNDDSYGSSNKKKSSYGSSNNDSYGSNNDDSYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGSSNKNKSSYGSSSNDDSYGSSNNDDSYGSSNKKKSSYGSNNDDSYGSNNDDSYGSSNKKKSSYGSSNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGSSNRNKNSYGSSNYGSSNNDDSYGSSNRGGRNQYGGDDDY
SIO_010081: YMR173W
subclass of: SO_0000673
so part of: YMR173W
location: 608689..609981
location: region:608689-609981:1
so has part: feature:608689-609981:1:exon

NP_013897.1
type: Protein
SIO_000068: ncbiprotein

S000004784
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:608689-609981:1:exon

YMR174C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAI3
locus tag: YMR174C
so part of: sequence
location: complement(<610159..>610365)
location: region:610159-610365:-1
so has part: feature:610159-610365:-1:exon
subclass of: SO_0000010

855212
type: Gene
SIO_000068: ncbigene

position:610159:-1
position: 610159
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:610365:-1
position: 610365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:610159-610365:-1:exon

YMR174C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAI3
locus tag: YMR174C
product: Pai3p
transcript id: NM_001182680.1
SIO_010081: YMR174C
subclass of: SO_0000673
so part of: YMR174C
location: complement(<610159..>610365)
location: region:610159-610365:-1
so has part: feature:610159-610365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:610159-610365:-1:exon

YMR174C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAI3
locus tag: YMR174C
experiment: EXISTENCE:direct assay:GO:0004866 endopeptidase inhibitor activity [PMID:17145748]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004866 endopeptidase inhibitor activity [PMID:2037077]
experiment: EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:2037077]
note: Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
codon start: 1
product: Pai3p
translation: MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE
SIO_010081: YMR174C
subclass of: SO_0000673
so part of: YMR174C
location: complement(610159..610365)
location: region:610159-610365:-1
so has part: feature:610159-610365:-1:exon

NP_013899.1
type: Protein
SIO_000068: ncbiprotein

S000004786
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:610159-610365:-1:exon

YMR175W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SIP18
locus tag: YMR175W
so part of: sequence
location: <611016..>611255
location: region:611016-611255:1
so has part: feature:611016-611255:1:exon
subclass of: SO_0000010

855213
type: Gene
SIO_000068: ncbigene

position:611016:1
position: 611016
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611255:1
position: 611255
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611016-611255:1:exon

YMR175W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SIP18
locus tag: YMR175W
product: Sip18p
transcript id: NM_001182681.1
SIO_010081: YMR175W
subclass of: SO_0000673
so part of: YMR175W
location: <611016..>611255
location: region:611016-611255:1
so has part: feature:611016-611255:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611016-611255:1:exon

YMR175W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SIP18
locus tag: YMR175W
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:12082171]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22181064]
experiment: EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:21420397]
note: Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication
codon start: 1
product: Sip18p
translation: MSNMMNKFAEKLQGNDDSHQKGKNAKSSNKERDDMNMDMGMGHDQSEGGMKMGHDQSGTKMNAGRGIANDWKTYENMKK
SIO_010081: YMR175W
subclass of: SO_0000673
so part of: YMR175W
location: 611016..611255
location: region:611016-611255:1
so has part: feature:611016-611255:1:exon

NP_013900.1
type: Protein
SIO_000068: ncbiprotein

S000004787
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611016-611255:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1323; Autonomously Replicating Sequence
so part of: sequence
location: 611275..611489
location: region:611275-611489:1
so has part: feature:611275-611489:1:region

S000118374
type: SGD
SIO_000068: sgd

position:611275:1
position: 611275
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:611489:1
position: 611489
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611275-611489:1:region

YMR175W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YMR175W-A
so part of: sequence
location: <611314..>611508
location: region:611314-611508:1
so has part: feature:611314-611508:1:exon
subclass of: SO_0000010

1466501
type: Gene
SIO_000068: ncbigene

position:611314:1
position: 611314
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611508:1
position: 611508
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611314-611508:1:exon

YMR175W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YMR175W-A
product: uncharacterized protein
transcript id: NM_001184660.1
SIO_010081: YMR175W-A
subclass of: SO_0000673
so part of: YMR175W-A
location: <611314..>611508
location: region:611314-611508:1
so has part: feature:611314-611508:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611314-611508:1:exon

YMR175W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YMR175W-A
codon start: 1
product: uncharacterized protein
translation: MNCLCLCSLYSKSISAYFSEFSSTNIYKSYLRLPSVLYYVCMMHTMMPNQLDAVGIQSSESLLM
SIO_010081: YMR175W-A
subclass of: SO_0000673
so part of: YMR175W-A
location: 611314..611508
location: region:611314-611508:1
so has part: feature:611314-611508:1:exon

NP_878143.1
type: Protein
SIO_000068: ncbiprotein

S000028848
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611314-611508:1:exon

YMR176W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM5
locus tag: YMR176W
so part of: sequence
location: <611740..>615975
location: region:611740-615975:1
so has part: feature:611740-615975:1:exon
subclass of: SO_0000010

855214
type: Gene
SIO_000068: ncbigene

position:611740:1
position: 611740
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:615975:1
position: 615975
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611740-615975:1:exon

YMR176W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM5
locus tag: YMR176W
product: Ecm5p
transcript id: NM_001182682.1
SIO_010081: YMR176W
subclass of: SO_0000673
so part of: YMR176W
location: <611740..>615975
location: region:611740-615975:1
so has part: feature:611740-615975:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611740-615975:1:exon

YMR176W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM5
locus tag: YMR176W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:23878396]
note: Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Ecm5p
translation: MSGHDSVTKISHILNEPVNEKVMVQNGFHESSKIADIELEIQERPSIKQWESPRSAVIPTSNHNFSPFLYTQFKSRGAAPFAPETIKSVDLVELPEGVPARVFHEKTGLFYQISPHSIPTFILAKKELPDPIKFYELVEDLGSVYGCVKLKIIPDADKFTQLNVDVDRLWFKARKQFFNSNEFQRTKIVDFYAKLYNFHNKIKKSTLTRIPSIDKRTLDLYRLRSCVKLRGGFNAVCEKKLWAQIGRELGYSGRIMSSLSTSLRSAYAKILLDFDIYEEEEQAARNNEKNEDMVESEIFRHSNSRSRDEEEPLHKKAKIHRDVFRAGSINHEFKRMRDIKHIKGFPTYFNSLTEFKLGYTQSTETTLPGYDFTFWENGMEIYDKSKYETKTSPVYNLRQYYEKSLAVFTAIVAKFGSSYPDLFAKHTTLPQKEFERLYFHLLSEHFIDFEIDTGLGLPCSMRSPGNNSSNEKFAIKNILDQWNLDNIPLNELSLLQHLDLDMANFTRTTYDIGMLFSCQGWSVSDHFLPSIDFNHLGSTKLVYSIAPKDMEKFEALIARGKSEWDTIQSRPRYSTSDDELKSFIETDFYKSFLDAEQSADYSNTGDNSKNSFPEDKIAGNTLHDGSQSDFIFEPNFILANGIKLYKTTQEQGSYIFKFPKAFTCSIGSGFYLSQNAKFAPSSWLRFSSEAAKWTSKMGFLPGLDVNQLLINALLNSNNPVLRKKCRDLISNYVVEEAENSKKLGELIGTVDVVYNKLNYISDISLESTGLSKIVVTHGALQRNLSLKEFVVLLEKPENGAHSICGIPIRDQSGNLNVCLHSYFDSASLGIALDGLDKPPTSYLLVHNEDFEKKWDVLMTSTFRNRTVPLNIIQYLISHTDSNTEFNRMLRSNFDDSLLLIEKCKKFIKTFVDVSCSVKDVDFGNGFNLRHLPLKFSDNMADNLESLYESVRKCSIEFSEKPTIIRLYHVSRQFPIDNRDIIDGNNLDLLKELYQKSLTIPLKVSYWTKLTRKICRLEWLSVYEHIFIERCDIKNEDPAKYSLPLLYSYFEFGLKYCDSEDIDKLGEVRKLILKYQDMMQKVRVFLKKDPPSKISLSDLEDVLLDIEEYRLPIQSSFFSELDYVIREIENAKKMNDVNILYNTDNIDKIDELIRKNDPKFVKFANQFNGSRLDKRPLASDNSGSVKAKQELKVFKLWNQHLDQIMQKNKFIEILPSIFRCLDLKSDKYIPLESCSKRQTKYCFCRRVEEGTAMVECEICKEWYHVDCISNGELVPPDDPNVLFVCSICTPPCMAVDNIEGVTFELDDLKRILVESLKLSLIPDPPILKNLFDVFAFALNFKNEMEKELFTNGYVNQLSSTHKIKYYLRKLKGSQCGFTNLTDPLRKHCQVKDAEAIKWLTDNGRIIITGIPN
SIO_010081: YMR176W
subclass of: SO_0000673
so part of: YMR176W
location: 611740..615975
location: region:611740-615975:1
so has part: feature:611740-615975:1:exon

NP_013901.1
type: Protein
SIO_000068: ncbiprotein

S000004788
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611740-615975:1:exon

YMR177W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MFT1
gene: MMT1
locus tag: YMR177W
gene synonym: MFT1
so part of: sequence
location: <616566..>618098
location: region:616566-618098:1
so has part: feature:616566-618098:1:exon
subclass of: SO_0000010

855215
type: Gene
SIO_000068: ncbigene

position:616566:1
position: 616566
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:618098:1
position: 618098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616566-618098:1:exon

YMR177W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MFT1
gene: MMT1
locus tag: YMR177W
gene synonym: MFT1
product: Mmt1p
transcript id: NM_001182683.1
SIO_010081: YMR177W
subclass of: SO_0000673
so part of: YMR177W
location: <616566..>618098
location: region:616566-618098:1
so has part: feature:616566-618098:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:616566-618098:1:exon

YMR177W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MFT1
gene: MMT1
locus tag: YMR177W
gene synonym: MFT1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9353309|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0006879 cellular iron ion homeostasis [PMID:9353309]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:9353309]
note: Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication
codon start: 1
product: Mmt1p
translation: MLRICVKRPCIKIVLSQVRPALLVRKENLHISTGVKVEKSSIINQKDPNKVRVEINELKRQAEIEKAAIKELEKNPQYQKLAEAFNSHDHVHLRESETEQNDIISLGTIRDYKSSKCEQADKPSSLNLHSHTHSHGHTHSHAAHNPLLVLSTEQIRKNAGVRITWVGLGVNVGIAIGKFFGGIVFHSQALFADAIHAISDMVSDLLTLLSVGLAANKPTADYPYGYGKIETVGSLAVSTILAMAGISIGWSSLCALVGPVIPHTIIDTIGNLGHAHTYSEDIIEDVTDINAAWIAAASIAAKEWIFRATRKIAINTNSNVLMANAWHHRVDSLTSLVALVAISTGYLVNIQSLDTIGGLIVSGLIIKAGGEGMCIAIKELIDQSVSRDDPRYLEIETLVKDTLNKLISNNNSQKPYGLKELTLLSSGPNLRGHLTLEVPLQKWGNILGVNEFEIVTHHLRNVLTNEVSNLRRLDIEYVEEKNGEENEHIKGQQNYKEDVLIKHDHTNTHI
SIO_010081: YMR177W
subclass of: SO_0000673
so part of: YMR177W
location: 616566..618098
location: region:616566-618098:1
so has part: feature:616566-618098:1:exon

NP_013902.1
type: Protein
SIO_000068: ncbiprotein

S000004789
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:616566-618098:1:exon

YMR178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FPY1
locus tag: YMR178W
so part of: sequence
location: <618479..>619303
location: region:618479-619303:1
so has part: feature:618479-619303:1:exon
subclass of: SO_0000010

855216
type: Gene
SIO_000068: ncbigene

position:618479:1
position: 618479
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:619303:1
position: 619303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:618479-619303:1:exon

YMR178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FPY1
locus tag: YMR178W
product: Fpy1p
transcript id: NM_001182684.1
SIO_010081: YMR178W
subclass of: SO_0000673
so part of: YMR178W
location: <618479..>619303
location: region:618479-619303:1
so has part: feature:618479-619303:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:618479-619303:1:exon

YMR178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FPY1
locus tag: YMR178W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0047884 FAD diphosphatase activity [PMID:29902190]
experiment: EXISTENCE:genetic interaction:GO:0042726 flavin-containing compound metabolic process [PMID:29902190]
note: FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress
codon start: 1
product: Fpy1p
translation: MVKVTAACIIIGDEVLNGKVVDTNSTFFAKYCFDHGIQLKEIATIGDDETQIVDTVRRLVKNYDFIISTGGIGPTHDDITYECMAKSFNLPCELDEECKERMRHKSDPEARLDADALKAHYQMATMPKGTNVKNYYVCDDLWVPICSISHKMYILPGIPQLFARMLKAFTPTLKKIYNLDKDPREYVRYFVRTHLTESQISKELKLIQDESTKVSEAIKIGSYPHFGMGFNTVSILGEKKDDSYLKSIVNRVVNNLEGEVISSELENKFSNQES
SIO_010081: YMR178W
subclass of: SO_0000673
so part of: YMR178W
location: 618479..619303
location: region:618479-619303:1
so has part: feature:618479-619303:1:exon

NP_013903.1
type: Protein
SIO_000068: ncbiprotein

S000004790
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:618479-619303:1:exon

YMR179W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPT21
locus tag: YMR179W
so part of: sequence
location: <619858..>622134
location: region:619858-622134:1
so has part: feature:619858-622134:1:exon
subclass of: SO_0000010

855217
type: Gene
SIO_000068: ncbigene

position:619858:1
position: 619858
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:622134:1
position: 622134
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:619858-622134:1:exon

YMR179W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPT21
locus tag: YMR179W
product: Spt21p
transcript id: NM_001182685.1
SIO_010081: YMR179W
subclass of: SO_0000673
so part of: YMR179W
location: <619858..>622134
location: region:619858-622134:1
so has part: feature:619858-622134:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:619858-622134:1:exon

YMR179W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPT21
locus tag: YMR179W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21057056]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:21057056]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8035801]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:21057056]
note: Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; binds with Spt10p to histone gene promoters during S phase; localizes to nuclear foci that become diffuse upon DNA replication stress
codon start: 1
product: Spt21p
translation: MSELSQMTLKILYTLDNGSNGSYLARSRAPKQVRVANIPSPFPTDSNEQTELRIGAIHLKTILHEIYLNSPEVLDHDTLKDGYDYNLYYRDICEVDEPLVSLGLLSGLRKKFHKNSPYQYTENNIGEEESEERDEVTEEEYEDESFIVTGRVCSNVSALLRRSYSNISNKKGRVVNNQIPEETLEVKLRFTKVITNLRTSGNNTTNSRISCLQMPSSLPSATLPFTPKSQSLFKTNQIKNSRNARTTITINNTNSGTVGRRQTNPMPAPKAVRTQSLPIWNLKPNIANTGFPRNSIAHKIYLADRKTEANQQNNQHQNIAYEINTLQNDNTIQRTKIDDSVSKRFDFMLNKRKSTKKVSPGIATIAKKPASININPKQPPKTSGEKKANDKQTIVKVKNSNSKNSAKSTQAGCRRSSVIEHLNDHDDSILSDILSEPGIEGQKLQQKQKGRKISLTSENDKENIPPQSITSKENKLEGDLDFNAEFPMSDFSDVVFKDEMGWFSNFNCNFFESPTSASASQLNQQNLKPSITLNDPNTCNTIALENEDVSELETAQNNKISLPSDVDKTSPIDSLSIPLIELTHSSSTTNMQRISIKEGSTLNITDSNNATPCDNDIKDRKASVIDSDNTKPQAGLINFSTPADQPASDNNVTASKKLTSMLETQQSKRSHEEVLDEEEEEEALKKQKAIPSSPCGMFNYHQPMELSEDIVEEEQGHNIGDDNESDKTNDLFSTFIHSGIRVSQVVTSPIGEFQSIKH
SIO_010081: YMR179W
subclass of: SO_0000673
so part of: YMR179W
location: 619858..622134
location: region:619858-622134:1
so has part: feature:619858-622134:1:exon

NP_013904.1
type: Protein
SIO_000068: ncbiprotein

S000004791
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:619858-622134:1:exon

YMR180C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTH1
gene: CTL1
locus tag: YMR180C
gene synonym: CTH1
so part of: sequence
location: complement(<622251..>623213)
location: region:622251-623213:-1
so has part: feature:622251-623213:-1:exon
subclass of: SO_0000010

855218
type: Gene
SIO_000068: ncbigene

position:622251:-1
position: 622251
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:623213:-1
position: 623213
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:622251-623213:-1:exon

YMR180C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTH1
gene: CTL1
locus tag: YMR180C
gene synonym: CTH1
product: polynucleotide 5'-phosphatase
transcript id: NM_001182686.1
SIO_010081: YMR180C
subclass of: SO_0000673
so part of: YMR180C
location: complement(<622251..>623213)
location: region:622251-623213:-1
so has part: feature:622251-623213:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:622251-623213:-1:exon

YMR180C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTH1
gene: CTL1
locus tag: YMR180C
gene synonym: CTH1
EC number: 3.1.3.33
experiment: EXISTENCE:direct assay:GO:0004651 polynucleotide 5'-phosphatase activity [PMID:10219091]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10219091]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10219091]
note: RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication
codon start: 1
product: polynucleotide 5'-phosphatase
translation: MSDQPETPSNSRNSHENVGAKKADANVASKFRSLHISETTKPLTSTRALYKTTRNNSRGATEFHKHVCKLAWKYLACIDKSSISHIEIEMKFGVITDKRTHRRMTPHNKPFIVQNRNGRLVSNVPEQMFSSFQELLRSKSENPSKCAPRVVKQVQKYTKDSIYNCNNASKVGKLTSWRCSEDLRNKELKLTYIKKVRVKDFLIRYPQSSLDAKISISLEVPEYETSAAFRNGFILQRTKSRSTYTFNDKMPLHLDLTKVTTTRRNSHQYTSHEVEVEMDPIFKETISANDREKFNEYMCSFLNASDLIRKAAERDNMLTT
SIO_010081: YMR180C
subclass of: SO_0000673
so part of: YMR180C
location: complement(622251..623213)
location: region:622251-623213:-1
so has part: feature:622251-623213:-1:exon

NP_013905.1
type: Protein
SIO_000068: ncbiprotein

S000004792
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:622251-623213:-1:exon