Saccharomyces cerevisiae S288C chromosome XII, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome XII, complete sequence.
sequence version: NC_001144.5
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001144.5
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169871
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
reference: 9
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006945.\n\nOn Apr 26, 2011 this sequence version replaced NC_001144.4.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 1078177
topology: linear
so has quality: SO_0000987
location: 1..1078177
location: region:1-1078177:1
RO_0002162: 559292

NC_001144
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII
author: Johnston, M.
author: Hillier, L.
author: Riles, L.
author: Albermann, K.
author: Andre, B.
author: Ansorge, W.
author: Benes, V.
author: Bruckner, M.
author: Delius, H.
author: Dubois, E.
author: Dusterhoft, A.
author: Entian, K.D.
author: Floeth, M.
author: Goffeau, A.
author: Hebling, U.
author: Heumann, K.
author: Heuss-Neitzel, D.
author: Hilbert, H.
author: Hilger, F.
author: Kleine, K.
author: Kotter, P.
author: Louis, E.J.
author: Messenguy, F.
author: Mewes, H.W.
author: Hoheisel, J.D. et al.
journal: Nature 387 (6632 SUPPL), 87-90 (1997)
pubmed: 9169871

9169871
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA
comments: Protein update by submitter

7
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA
comments: Protein update by submitter

8
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA
comments: Sequence update by submitter

9
title: Direct Submission
journal: Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1078177:1
position: 1078177
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-1078177:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: XII

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL12L; Telomeric region on the left arm of Chromosome XII; composed of an X element core sequence, X element combinatorial repeats, and three distinct regions of telomeric repeats separated by two short Y' elements
so part of: sequence
location: complement(1..12085)
location: region:1-12085:-1
so has part: feature:1-12085:-1:region

S000028910
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:12085:-1
position: 12085
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-12085:-1:region

YLL067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL067C
so part of: sequence
location: complement(<585..>4301)
location: region:585-4301:-1
so has part: feature:585-4301:-1:exon
subclass of: SO_0000010

850659
type: Gene
SIO_000068: ncbigene

position:585:-1
position: 585
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:4301:-1
position: 4301
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:585-4301:-1:exon

YLL067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL067C
product: Y' element ATP-dependent helicase
transcript id: NM_001181887.1
SIO_010081: YLL067C
subclass of: SO_0000673
so part of: YLL067C
location: complement(join(<585..3915,4015..>4301))
location: region:585-4301:-1
so has part: feature:4015-4301:-1:exon
so has part: feature:585-3915:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:4015-4301:-1:exon

position:4015:-1
position: 4015
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:585-3915:-1:exon

position:3915:-1
position: 3915
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLL067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL067C
EC number: 3.6.4.12
note: Putative Y' element ATP-dependent helicase
codon start: 1
product: Y' element ATP-dependent helicase
translation: MRTFTDFVSGAPIVRSLQKSTIRRYGYNLAPHMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYNKNGSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSNTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSSTNATTTASINVRTSATTTESTNSNTNATTTESTNSSTNATTTEGTNSNTSATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWVDLANVEVLAADNTRVPC
SIO_010081: YLL067C
subclass of: SO_0000673
so part of: YLL067C
location: complement(join(585..3915,4015..4301))
location: region:585-4301:-1
so has part: feature:4015-4301:-1:exon
so has part: feature:585-3915:-1:exon

NP_013033.1
type: Protein
SIO_000068: ncbiprotein

S000003990
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:4015-4301:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:585-3915:-1:exon

YLL066W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL066W-B
so part of: sequence
location: <5605..>5775
location: region:5605-5775:1
so has part: feature:5605-5775:1:exon
subclass of: SO_0000010

1466404
type: Gene
SIO_000068: ncbigene

position:5605:1
position: 5605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5775:1
position: 5775
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5605-5775:1:exon

YLL066W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL066W-B
product: uncharacterized protein
transcript id: NM_001184605.1
SIO_010081: YLL066W-B
subclass of: SO_0000673
so part of: YLL066W-B
location: <5605..>5775
location: region:5605-5775:1
so has part: feature:5605-5775:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:5605-5775:1:exon

YLL066W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL066W-B
note: hypothetical protein; overexpression causes a cell cycle delay or arrest
codon start: 1
product: uncharacterized protein
translation: MSLRPCLTPSSMQYSDIYIHHTHTPHPHHTHTHTHHTPTHSLTSTFTLAVTPYPAF
SIO_010081: YLL066W-B
subclass of: SO_0000673
so part of: YLL066W-B
location: 5605..5775
location: region:5605-5775:1
so has part: feature:5605-5775:1:exon

NP_878115.1
type: Protein
SIO_000068: ncbiprotein

S000028672
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:5605-5775:1:exon

YLL066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL066C
so part of: sequence
location: complement(<6120..>9836)
location: region:6120-9836:-1
so has part: feature:6120-9836:-1:exon
subclass of: SO_0000010

850660
type: Gene
SIO_000068: ncbigene

position:6120:-1
position: 6120
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:9836:-1
position: 9836
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6120-9836:-1:exon

YLL066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL066C
product: Y' element ATP-dependent helicase
transcript id: NM_001181886.1
SIO_010081: YLL066C
subclass of: SO_0000673
so part of: YLL066C
location: complement(join(<6120..9450,9550..>9836))
location: region:6120-9836:-1
so has part: feature:9550-9836:-1:exon
so has part: feature:6120-9450:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:9550-9836:-1:exon

position:9550:-1
position: 9550
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:6120-9450:-1:exon

position:9450:-1
position: 9450
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLL066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL066C
EC number: 3.6.4.12
note: Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene
codon start: 1
product: Y' element ATP-dependent helicase
translation: MRTFTDFVSGAPIVRSLQKSTIRRYGYNLAPHMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYNKNGSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSNTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFGLCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWVDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
SIO_010081: YLL066C
subclass of: SO_0000673
so part of: YLL066C
location: complement(join(6120..9450,9550..9836))
location: region:6120-9836:-1
so has part: feature:9550-9836:-1:exon
so has part: feature:6120-9450:-1:exon

NP_013034.1
type: Protein
SIO_000068: ncbiprotein

S000003989
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:9550-9836:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:6120-9450:-1:exon

YLL064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU18
locus tag: YLL064C
so part of: sequence
location: complement(<13083..>13445)
location: region:13083-13445:-1
so has part: feature:13083-13445:-1:exon
subclass of: SO_0000010

850662
type: Gene
SIO_000068: ncbigene

position:13083:-1
position: 13083
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:13445:-1
position: 13445
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:13083-13445:-1:exon

YLL064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU18
locus tag: YLL064C
product: seripauperin PAU18
transcript id: NM_001181884.1
SIO_010081: YLL064C
subclass of: SO_0000673
so part of: YLL064C
location: complement(<13083..>13445)
location: region:13083-13445:-1
so has part: feature:13083-13445:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:13083-13445:-1:exon

YLL064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU18
locus tag: YLL064C
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p
codon start: 1
product: seripauperin PAU18
translation: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSTRLKPAISKALSKDGIYTIAN
SIO_010081: YLL064C
subclass of: SO_0000673
so part of: YLL064C
location: complement(13083..13445)
location: region:13083-13445:-1
so has part: feature:13083-13445:-1:exon

NP_013036.1
type: Protein
SIO_000068: ncbiprotein

S000003987
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:13083-13445:-1:exon

YLL063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AYT1
locus tag: YLL063C
so part of: sequence
location: complement(<14648..>16072)
location: region:14648-16072:-1
so has part: feature:14648-16072:-1:exon
subclass of: SO_0000010

850663
type: Gene
SIO_000068: ncbigene

position:14648:-1
position: 14648
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:16072:-1
position: 16072
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14648-16072:-1:exon

YLL063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AYT1
locus tag: YLL063C
product: acetyltransferase
transcript id: NM_001181883.1
SIO_010081: YLL063C
subclass of: SO_0000673
so part of: YLL063C
location: complement(<14648..>16072)
location: region:14648-16072:-1
so has part: feature:14648-16072:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14648-16072:-1:exon

YLL063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AYT1
locus tag: YLL063C
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:mutant phenotype:GO:0043387 mycotoxin catabolic process [PMID:12478589]
experiment: EXISTENCE:mutant phenotype:GO:0045462 trichothecene 3-O-acetyltransferase activity [PMID:12478589]
note: Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; localized to peroxisomes
codon start: 1
product: acetyltransferase
translation: MFRVKIISQKRTKSVQMLENDQLDILGQQPSLYKLYTQICSIYRVPDPSAHDHIVNTLTRGLETLAKNFQWLAGNVVNEGADEGNTGTYRIVPSDKIPLIVQDLREDLSAPTMDSLEKADFPIYMLDEKTFAPCMTINPPGNTIGMAAKSGPVFAVQANFISGGLVLTIVGQHNIMDITGQESIINLLNKSCHQKPFSDEELLIGNIDKSKSIPLFDETWEPDTTLVHEIVETSRNTSGEEKEQSCSSNSTWAYVEFSAISLQNLRILAMQTCTSGTKFVSTDDIVTAFIWKSVSRARLSRLKPETKSNLGRAVDVRKRLGLPETYPGLLVNMTFNTGSLKSLDHKSLGVLASQIRRKLDPKVFDLAYNTCALATLLSRCPDKTKVSIPQPIDTLSGIMVSSWAKVSLYDVDFNLGLGKPKSVRRPRFISLESLIYFMPRSSRGEMVVALCLRDKDWECLNADKEWTNYATHIG
SIO_010081: YLL063C
subclass of: SO_0000673
so part of: YLL063C
location: complement(14648..16072)
location: region:14648-16072:-1
so has part: feature:14648-16072:-1:exon

NP_013037.1
type: Protein
SIO_000068: ncbiprotein

S000003986
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14648-16072:-1:exon

YLL062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MHT1
locus tag: YLL062C
so part of: sequence
location: complement(<16639..>17613)
location: region:16639-17613:-1
so has part: feature:16639-17613:-1:exon
subclass of: SO_0000010

850664
type: Gene
SIO_000068: ncbigene

position:16639:-1
position: 16639
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17613:-1
position: 17613
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:16639-17613:-1:exon

YLL062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MHT1
locus tag: YLL062C
product: S-adenosylmethionine-homocysteine S-methyltransferase MHT1
transcript id: NM_001181882.1
SIO_010081: YLL062C
subclass of: SO_0000673
so part of: YLL062C
location: complement(<16639..>17613)
location: region:16639-17613:-1
so has part: feature:16639-17613:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:16639-17613:-1:exon

YLL062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MHT1
locus tag: YLL062C
EC number: 2.1.1.10
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity [PMID:11013242]
experiment: EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:11013242]
note: S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
codon start: 1
product: S-adenosylmethionine-homocysteine S-methyltransferase MHT1
translation: MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS
SIO_010081: YLL062C
subclass of: SO_0000673
so part of: YLL062C
location: complement(16639..17613)
location: region:16639-17613:-1
so has part: feature:16639-17613:-1:exon

NP_013038.1
type: Protein
SIO_000068: ncbiprotein

S000003985
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:16639-17613:-1:exon

YLL061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MMP1
locus tag: YLL061W
so part of: sequence
location: <17956..>19707
location: region:17956-19707:1
so has part: feature:17956-19707:1:exon
subclass of: SO_0000010

850665
type: Gene
SIO_000068: ncbigene

position:17956:1
position: 17956
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:19707:1
position: 19707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17956-19707:1:exon

YLL061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MMP1
locus tag: YLL061W
product: S-methylmethionine permease MMP1
transcript id: NM_001181881.1
SIO_010081: YLL061W
subclass of: SO_0000673
so part of: YLL061W
location: <17956..>19707
location: region:17956-19707:1
so has part: feature:17956-19707:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17956-19707:1:exon

YLL061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MMP1
locus tag: YLL061W
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000100 S-methylmethionine transmembrane transporter activity [PMID:10497160]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10497160]
experiment: EXISTENCE:mutant phenotype:GO:0015806 S-methylmethionine transport [PMID:10497160]
note: High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
codon start: 1
product: S-methylmethionine permease MMP1
translation: MDEFESTKLSKVQFSTSVLSTPSNEGNNLIHRFKNSFKRNDSPAIQEGLLYSELSEEEKIQWDLANQPYKKVLDQRHLTMIAIGGTLGTGLFIGLGESLASGPASLLIGFLLVGASMLCVVQCGAELSCQYPVSGSYALHASRFIDPSVGFSIGINYLLMWLISYPSELVGCSLTISYWAPSVNPAAWVAIAFVLSMLLNLFGARGFAESEFYMSIFKIVALFIFIIIGIVLIAGGGPDSTGYIGTKYWHDPGSFAVPVFKNLCNTFVSAAYSFSGTEMVVLTSTEARSVSSVSRAAKGTFWRIIIFYIVTVIIIGCLVPYNDPRLISGSSSEDITASPFVIALSNTGAMGTRVSHFMNAVILIAVFSVCNSCVYASSRLIQGLATAGQLPKICAYMDRNGRPLVGMAICGAFGLLGFLVVSKNQGTVFTWLFALCSISFFTTWFCICFCQVRFRMAMKAQGRSKDDIIYRSTLGIYGGIFGCILNVLLVIGEIYVSAAPVGSPSSAANFFEYCMSIPIMIAVYIGHRIYRRDWRHWYIKRMDIDLDSGHSLEDFEATKLERDEDKKYVSSKPLYYRIYRFFC
SIO_010081: YLL061W
subclass of: SO_0000673
so part of: YLL061W
location: 17956..19707
location: region:17956-19707:1
so has part: feature:17956-19707:1:exon

NP_013039.1
type: Protein
SIO_000068: ncbiprotein

S000003984
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17956-19707:1:exon

YLL060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GTT2
locus tag: YLL060C
so part of: sequence
location: complement(<21138..>21839)
location: region:21138-21839:-1
so has part: feature:21138-21839:-1:exon
subclass of: SO_0000010

850666
type: Gene
SIO_000068: ncbigene

position:21138:-1
position: 21138
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:21839:-1
position: 21839
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:21138-21839:-1:exon

YLL060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GTT2
locus tag: YLL060C
product: glutathione transferase GTT2
transcript id: NM_001181880.1
SIO_010081: YLL060C
subclass of: SO_0000673
so part of: YLL060C
location: complement(<21138..>21839)
location: region:21138-21839:-1
so has part: feature:21138-21839:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:21138-21839:-1:exon

YLL060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GTT2
locus tag: YLL060C
EC number: 2.5.1.18
experiment: EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:9792709]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006749 glutathione metabolic process [PMID:9792709]
note: Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
codon start: 1
product: glutathione transferase GTT2
translation: MNGRGFLIYNGGEKMKQKMIIYDTPAGPYPARVRIALAEKNMLSSVQFVRINLWKGEHKKPEFLAKNYSGTVPVLELDDGTLIAECTAITEYIDALDGTPTLTGKTPLEKGVIHMMNKRAELELLDPVSVYFHHATPGLGPEVELYQNKEWGLRQRDKALHGMHYFDTVLRERPYVAGDSFSMADITVIAGLIFAAIVKLQVPEECEALRAWYKRMQQRPSVKKLLEIRSKSS
SIO_010081: YLL060C
subclass of: SO_0000673
so part of: YLL060C
location: complement(21138..21839)
location: region:21138-21839:-1
so has part: feature:21138-21839:-1:exon

NP_013040.1
type: Protein
SIO_000068: ncbiprotein

S000003983
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:21138-21839:-1:exon

YLL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HSU1
locus tag: YLL058W
so part of: sequence
location: <23569..>25296
location: region:23569-25296:1
so has part: feature:23569-25296:1:exon
subclass of: SO_0000010

850668
type: Gene
SIO_000068: ncbigene

position:23569:1
position: 23569
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25296:1
position: 25296
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:23569-25296:1:exon

YLL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HSU1
locus tag: YLL058W
product: cystathionine gamma-synthase
transcript id: NM_001181878.1
SIO_010081: YLL058W
subclass of: SO_0000673
so part of: YLL058W
location: <23569..>25296
location: region:23569-25296:1
so has part: feature:23569-25296:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:23569-25296:1:exon

YLL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HSU1
locus tag: YLL058W
EC number: 2.5.1.48
experiment: EXISTENCE:direct assay:GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity [PMID:36379252]
experiment: EXISTENCE:mutant phenotype:GO:0006790 sulfur compound metabolic process [PMID:36379252]
note: Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene
codon start: 1
product: cystathionine gamma-synthase
translation: MTEIEFGQPLPSNLDYAVSFGIPTWDSAIGYAEKVPEVIGKMATGYPRYFPQPPVQRLCAYFVKKFGRGSENCRPFPSVNLGLKCFEYVKSVSGPESKAHLEVETVTIKNRGAKTSKEPAELVLTIAAVLASEEEFETVKEYWKLRGECVSSRLALSVNQLLDCANHGSEQVLRELEAGVFAAKKGEEKAKNLIKGRIVENRFRPFGLEKKTPNWEGLNLNPNEDVYLVSSGMSAISTARNLLTFWEEKKNSGDSLNKTTSDQKKKPLLCDTVGIFGFPFKDTQVIMTKFGKCKFFGFGNSRDVVELQKFLETSKQRILAVFVETPSNPLLNMPDLKKLRSLADQYGFFIVIDDTIGGLNVDILPYADIVSTSLTKLFNGASNVMGGSVVLNPKSSLYPYAREYFRSANFEDLLWCEDAIVLERNSRDFEDRTLRANANTGILLNDLLLPEEGKICKKIYYPTVTSKETFENYESVRNERGGYGCLFSVAFFNEGDAKAFYDSLKVFKGPSNGTNFTLACPYVHLAHHSELEEVSKFGADPNIIRVSVGLEDIQWLLKVFSSALDVVKSRGSKHS
SIO_010081: YLL058W
subclass of: SO_0000673
so part of: YLL058W
location: 23569..25296
location: region:23569-25296:1
so has part: feature:23569-25296:1:exon

NP_013042.1
type: Protein
SIO_000068: ncbiprotein

S000003981
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:23569-25296:1:exon

YLL057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: JLP1
locus tag: YLL057C
so part of: sequence
location: complement(<25756..>26994)
location: region:25756-26994:-1
so has part: feature:25756-26994:-1:exon
subclass of: SO_0000010

850669
type: Gene
SIO_000068: ncbigene

position:25756:-1
position: 25756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26994:-1
position: 26994
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25756-26994:-1:exon

YLL057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: JLP1
locus tag: YLL057C
product: sulfonate dioxygenase
transcript id: NM_001181877.1
SIO_010081: YLL057C
subclass of: SO_0000673
so part of: YLL057C
location: complement(<25756..>26994)
location: region:25756-26994:-1
so has part: feature:25756-26994:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25756-26994:-1:exon

YLL057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: JLP1
locus tag: YLL057C
experiment: EXISTENCE:direct assay:GO:0000907 sulfonate dioxygenase activity [PMID:10482536]
experiment: EXISTENCE:mutant phenotype:GO:0044273 sulfur compound catabolic process [PMID:10482536]
note: Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
codon start: 1
product: sulfonate dioxygenase
translation: MSPAAAQTAIPLPSTDLPVKIITNGLKNLNYTSKQGYGNFDTHFYDGQDEVSPSGLLKIRKSYREKSKYPDYLPTWDPTEKYGPLEFHEYHDPALRADGNFSNLFAKENVGQLKVKKITPKLGLEINGIQLTDLSDAAKDELALLVAQKGVVVFRNQNFADEGPDYVTEYGRHFGKLHIHQTSGHPQNNPELHITFRRPDAEEFARVFDDSTSSGGWHTDVSYELQPPSYTFFSVVEGPDGGGDTLFADTIEAFDRLSKPLQDFLSTLHVIHSSKEQAENSQRQGGIKRRAPVTHIHPLVRVHPVLKKKCLYVNRAFSRKIVELKRQESESLLNFLYNLVESSHDLQLRAKWEPHSVVIWDNRRVQHSAVIDWEEPIHRHAFRITPQAERPVEDLKFLNDENYYPSSLTLDI
SIO_010081: YLL057C
subclass of: SO_0000673
so part of: YLL057C
location: complement(25756..26994)
location: region:25756-26994:-1
so has part: feature:25756-26994:-1:exon

NP_013043.1
type: Protein
SIO_000068: ncbiprotein

S000003980
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25756-26994:-1:exon

YLL056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL056C
so part of: sequence
location: complement(<27409..>28305)
location: region:27409-28305:-1
so has part: feature:27409-28305:-1:exon
subclass of: SO_0000010

850670
type: Gene
SIO_000068: ncbigene

position:27409:-1
position: 27409
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:28305:-1
position: 28305
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27409-28305:-1:exon

YLL056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL056C
product: uncharacterized protein
transcript id: NM_001181876.1
SIO_010081: YLL056C
subclass of: SO_0000673
so part of: YLL056C
location: complement(<27409..>28305)
location: region:27409-28305:-1
so has part: feature:27409-28305:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:27409-28305:-1:exon

YLL056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL056C
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:28265724]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:28265724]
note: NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively
codon start: 1
product: uncharacterized protein
translation: MKVFITGASGFIGSAVLSELISSGHEVVGLARSDEAAAKIKSIDPAAKILRGDLKDLEILKKGATESDGVIHLGFVHDFKNFEQCCEIDRQATVAMLESLKGSNKPFLYTNGTLSLRPNKVANEQDGIDEDSKILRAVTEQVALSYKDKGVSARIVRLPFSVHGKGDKAFVPILMNIAKAAGKSGYVGQGTNAWAAVHRLDTAPLFRLVLEKGKTGQVYHCVGEQGIPFKDIARVIGEILNVPVASIPVDDAESHFGFLTCFVTRDGPVSSEGTRKELGWQPQQIGLLEDIRANYSLN
SIO_010081: YLL056C
subclass of: SO_0000673
so part of: YLL056C
location: complement(27409..28305)
location: region:27409-28305:-1
so has part: feature:27409-28305:-1:exon

NP_013044.1
type: Protein
SIO_000068: ncbiprotein

S000003979
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:27409-28305:-1:exon

YLL055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YCT1
locus tag: YLL055W
so part of: sequence
location: <30109..>31704
location: region:30109-31704:1
so has part: feature:30109-31704:1:exon
subclass of: SO_0000010

850671
type: Gene
SIO_000068: ncbigene

position:30109:1
position: 30109
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31704:1
position: 31704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:30109-31704:1:exon

YLL055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YCT1
locus tag: YLL055W
product: Yct1p
transcript id: NM_001181875.1
SIO_010081: YLL055W
subclass of: SO_0000673
so part of: YLL055W
location: <30109..>31704
location: region:30109-31704:1
so has part: feature:30109-31704:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:30109-31704:1:exon

YLL055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YCT1
locus tag: YLL055W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0033229 cysteine transmembrane transporter activity [PMID:17435223]
experiment: EXISTENCE:direct assay:GO:0042883 cysteine transport [PMID:17435223]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0033229 cysteine transmembrane transporter activity [PMID:17435223]
experiment: EXISTENCE:mutant phenotype:GO:0042883 cysteine transport [PMID:17435223]
note: High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
codon start: 1
product: Yct1p
translation: MSKVDVKIGADSISSSDEILVPSRLADVTLAFMEENDAAVPEITPEQEKKLKRKLFLTIFTFVSAINLLLYMDKATLSYDSILGFFEDTGLTQNTYNTVNTLFYVGFAIGQFPGQYLAQKLPLGKFLGGLLATWTILIFLSCTAYNFSGVVALRFFLGLTESVVIPILITTMGMFFDASERAAAQPFFFAACMGSPIPTGFIAYGVLHITNPSISLWKIFTIIIGGLTFIMTVVVILWFPNNPADVKFFSIQERVWIIRRVQASTGSSIEQKVFKKSQFREAMKDYITWLFGLFFLLQQLANNLPYQQNLLFEGMGGVDALGSTLVSVAGAGFAVVCAFIATLMLAKWKNISALTAIFWTLPALVGSIAAAALPWDNKIGILANICMAGQIFGIPFIIALSWASSSASGYTKKLTRSSVSLFAMGIANIISPQIWREKDSPRFLPAWIVQIVLSFSLAPAILLLIHFILKRRNNQRLKNYDENLQNYLDRIQLIESENPSSIEEGKVVTHENNLAVFDLTDLENETFIYPL
SIO_010081: YLL055W
subclass of: SO_0000673
so part of: YLL055W
location: 30109..31704
location: region:30109-31704:1
so has part: feature:30109-31704:1:exon

NP_013045.1
type: Protein
SIO_000068: ncbiprotein

S000003978
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:30109-31704:1:exon

YLL055W
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
gene: YCT1
locus tag: YLL055W
note: ARS1202; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
SIO_010081: YLL055W
subclass of: SO_0000673
so part of: YLL055W
location: 30209..31384
location: region:30209-31384:1
so has part: feature:30209-31384:1:exon

S000130180
type: SGD
SIO_000068: sgd

position:30209:1
position: 30209
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:31384:1
position: 31384
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:30209-31384:1:exon

YLL054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL054C
so part of: sequence
location: complement(<32673..>35204)
location: region:32673-35204:-1
so has part: feature:32673-35204:-1:exon
subclass of: SO_0000010

850672
type: Gene
SIO_000068: ncbigene

position:32673:-1
position: 32673
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:35204:-1
position: 35204
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:32673-35204:-1:exon

YLL054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL054C
product: uncharacterized protein
transcript id: NM_001181874.2
SIO_010081: YLL054C
subclass of: SO_0000673
so part of: YLL054C
location: complement(<32673..>35204)
location: region:32673-35204:-1
so has part: feature:32673-35204:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:32673-35204:-1:exon

YLL054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL054C
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
note: hypothetical protein with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSIASQKKVKPSFVCLRCKQRKIKCDKLWPTCSKCKASSSICSYEVEPGRINKSPTIENAPHRDIRNITPASMSASGSFTSILNPSTKDWEMKNFAMNLSNAHDKLVVMNNTTIVDSPFAFHSILQHDLYAKALTTCIHERILIDVERHRENVSANNKKRELNLTIGDIGPLFFIDKAALKFIENTSKTSKLYPPIDFLYNTYDYEQAHPEENNDKISINILLEELSKYFLNKNEVDGLIVDFYKTIYPVYPLLEISLFEDNIRELLQLNEFNGYNIVFAGKDSRRKLETITLLTIILAFSYRRLSLSTSHSFKESFGVKSNNLTLLAHKLLALMNVFQYVNEHTLCCLLYFFILRYLNPDQADMYPTHSDILNLKFLENVAIKLGLNEEPFQYTRYVSESDDYPRLFNLRRKLWLGVQFLKFGILIPEGDSDILSLEYLRSFMKTDESLPELFERNYASTNNLDLSLMATAENIYHLHLSLQVLLTSCFPINGPSYLKEVLDNIDKTKDFLNQKFPLILSSLGEPRMKSLHINVPSSLANEESFDFSTFEENETFIANVISYTCTMNIYDSLSLHFENQCFKNALEYKTYYHRFTFTAIQDYLTLLKLISEYFNGSLLHLREPFGFATQKVVRFSIHRLLIFQATLLVRLFYKKDTCDRSSAAMGMLNDRNGRLSRVIEKMIKLMSYHMKLLVEIVISKLEKSYLGSFISVSIFRYIIYLVDTDALSAFISDYWKSDAVMDERYSRIHRIVGLKWGMGRDKSFSFTSKLNNPQFLGSLDLEILEELEKLISAQEFSRNFTEDVDESLQSEIDLMNYDNEALNQLMAIDLDKLLGIFPNLSNF
SIO_010081: YLL054C
subclass of: SO_0000673
so part of: YLL054C
location: complement(32673..35204)
location: region:32673-35204:-1
so has part: feature:32673-35204:-1:exon

NP_013046.2
type: Protein
SIO_000068: ncbiprotein

S000003977
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:32673-35204:-1:exon

YLL053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL053C
so part of: sequence
location: complement(<35503..>35961)
location: region:35503-35961:-1
so has part: feature:35503-35961:-1:exon
subclass of: SO_0000010

850673
type: Gene
SIO_000068: ncbigene

position:35503:-1
position: 35503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:35961:-1
position: 35961
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35503-35961:-1:exon

YLL053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL053C
product: uncharacterized protein
transcript id: NM_001181873.1
SIO_010081: YLL053C
subclass of: SO_0000673
so part of: YLL053C
location: complement(<35503..>35961)
location: region:35503-35961:-1
so has part: feature:35503-35961:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:35503-35961:-1:exon

YLL053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL053C
note: Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
codon start: 1
product: uncharacterized protein
translation: MWFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYHWIYWISPLLGAFLAWSVWQLLQILDYTTYVNAEKAAGQKKED
SIO_010081: YLL053C
subclass of: SO_0000673
so part of: YLL053C
location: complement(35503..35961)
location: region:35503-35961:-1
so has part: feature:35503-35961:-1:exon

NP_013047.1
type: Protein
SIO_000068: ncbiprotein

S000003976
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:35503-35961:-1:exon

YLL052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AQY2
locus tag: YLL052C
so part of: sequence
location: complement(<35912..>36361)
location: region:35912-36361:-1
so has part: feature:35912-36361:-1:exon
subclass of: SO_0000010

850674
type: Gene
SIO_000068: ncbigene

position:35912:-1
position: 35912
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36361:-1
position: 36361
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35912-36361:-1:exon

YLL052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AQY2
locus tag: YLL052C
product: Aqy2p
transcript id: NM_001181872.1
SIO_010081: YLL052C
subclass of: SO_0000673
so part of: YLL052C
location: complement(<35912..>36361)
location: region:35912-36361:-1
so has part: feature:35912-36361:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:35912-36361:-1:exon

YLL052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AQY2
locus tag: YLL052C
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11168368]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11168368]
experiment: EXISTENCE:direct assay:GO:0006833 water transport [PMID:11158584]
experiment: EXISTENCE:direct assay:GO:0015250 water channel activity [PMID:11158584]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:11158584]
experiment: EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:11158584]
note: Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
codon start: 1
product: Aqy2p
translation: MSNESNDLEKNISHLDPTGVDNAYIPPEQPETKHSRFNIDRDTLRNHFIAAVGEFCGTFMFLWCAYVICNVANHDVALTTEPEGSHPGQLIMIALGFGFSVMFSIWCFWWGFEPSRFSLFVFGQSHLTSQMCSDVVSSDHCWDGCWWCR
SIO_010081: YLL052C
subclass of: SO_0000673
so part of: YLL052C
location: complement(35912..36361)
location: region:35912-36361:-1
so has part: feature:35912-36361:-1:exon

NP_013048.1
type: Protein
SIO_000068: ncbiprotein

S000003975
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:35912-36361:-1:exon

YLL051C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRE6
locus tag: YLL051C
so part of: sequence
location: complement(<37333..>39471)
location: region:37333-39471:-1
so has part: feature:37333-39471:-1:exon
subclass of: SO_0000010

850675
type: Gene
SIO_000068: ncbigene

position:37333:-1
position: 37333
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:39471:-1
position: 39471
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:37333-39471:-1:exon

YLL051C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRE6
locus tag: YLL051C
product: putative ferric-chelate reductase
transcript id: NM_001181871.1
SIO_010081: YLL051C
subclass of: SO_0000673
so part of: YLL051C
location: complement(<37333..>39471)
location: region:37333-39471:-1
so has part: feature:37333-39471:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:37333-39471:-1:exon

YLL051C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRE6
locus tag: YLL051C
EC number: 1.16.1.9
experiment: EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:17681937]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17553781|PMID:17681937]
experiment: EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:17553781]
experiment: EXISTENCE:mutant phenotype:GO:0000293 ferric-chelate reductase activity [PMID:17681937]
experiment: EXISTENCE:mutant phenotype:GO:0006880 intracellular sequestering of iron ion [PMID:17681937]
note: Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway
codon start: 1
product: putative ferric-chelate reductase
translation: MHRTLLFLTWLISLTKAFNIKLPHTEKKDHLESNAVLACASYINTLKWSFDSSVVPGFYSTICSYSPAFDTWSLCIFNSLTDQIIPMDNTSFEESLGNVRKTCSFVDKKFSNISLEQYYSSLNNASSHALEDYGSIESLSTSIRVDRETRSRWIRAFHAHAYNLDISSVYGAYLTYYFVIVGIIAVFFHMSHYNGLNRALFASRFVNYIRGHFVLPTFLVDKHANHFKFLNVEVFTGLMPNSLEAWIIFGYTLANIIFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFISFHKWIGRIMVLNATIHSLSYSLFAIINHAFKISNKQLYWKFGIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLIWGLEKLFRIWNILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHSKPGQYCFIYFLHPLVFWQCHPFTIIDEGEKCVLVIKPKSGLTRFIYNHILQSLNGKLQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLIMAIKNPSFLNGYKSEILELKNSRSHVNVQVYLTQKTAVTKAANARDQLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLVDDVRNTVSQKLLGYPERIIEYFEEYQCW
SIO_010081: YLL051C
subclass of: SO_0000673
so part of: YLL051C
location: complement(37333..39471)
location: region:37333-39471:-1
so has part: feature:37333-39471:-1:exon

NP_013049.1
type: Protein
SIO_000068: ncbiprotein

S000003974
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:37333-39471:-1:exon

YLL050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COF1
locus tag: YLL050C
so part of: sequence
location: complement(<39804..>40414)
location: region:39804-40414:-1
so has part: feature:39804-40414:-1:exon
subclass of: SO_0000010

850676
type: Gene
SIO_000068: ncbigene

position:39804:-1
position: 39804
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:40414:-1
position: 40414
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:39804-40414:-1:exon

YLL050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COF1
locus tag: YLL050C
product: cofilin
transcript id: NM_001181870.1
SIO_010081: YLL050C
subclass of: SO_0000673
so part of: YLL050C
location: complement(join(<39804..40221,40401..>40414))
location: region:39804-40414:-1
so has part: feature:40401-40414:-1:exon
so has part: feature:39804-40221:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40401-40414:-1:exon

position:40401:-1
position: 40401
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:39804-40221:-1:exon

position:40221:-1
position: 40221
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLL050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COF1
locus tag: YLL050C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:16569665]
experiment: EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:16569665|PMID:8421056|PMID:8440472]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8163554|PMID:8421056]
experiment: EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:14680631|PMID:8421056]
experiment: EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:16569665|PMID:8421056|PMID:8440472]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:22553351]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:16569665|PMID:17875745]
experiment: EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:22553351]
note: Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
codon start: 1
product: cofilin
translation: MSRSGVAVADESLTAFNDLKLGKKYKFILFGLNDAKTEIVVKETSTDPSYDAFLEKLPENDCLYAIYDFEYEINGNEGKRSKIVFFTWSPDTAPVRSKMVYASSKDALRRALNGVSTDVQGTDFSEVSYDSVLERVSRGAGSH
SIO_010081: YLL050C
subclass of: SO_0000673
so part of: YLL050C
location: complement(join(39804..40221,40401..40414))
location: region:39804-40414:-1
so has part: feature:40401-40414:-1:exon
so has part: feature:39804-40221:-1:exon

NP_013050.1
type: Protein
SIO_000068: ncbiprotein

S000003973
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40401-40414:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:39804-40221:-1:exon

YLL049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LDB18
locus tag: YLL049W
so part of: sequence
location: <40666..>41205
location: region:40666-41205:1
so has part: feature:40666-41205:1:exon
subclass of: SO_0000010

850677
type: Gene
SIO_000068: ncbigene

position:40666:1
position: 40666
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:41205:1
position: 41205
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40666-41205:1:exon

YLL049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LDB18
locus tag: YLL049W
product: Ldb18p
transcript id: NM_001181869.1
SIO_010081: YLL049W
subclass of: SO_0000673
so part of: YLL049W
location: <40666..>41205
location: region:40666-41205:1
so has part: feature:40666-41205:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40666-41205:1:exon

YLL049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LDB18
locus tag: YLL049W
experiment: EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:18245366]
experiment: EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:18245366]
note: Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
codon start: 1
product: Ldb18p
translation: MPGLKLVEALEYRCDRLERLIGAGYSANSDVSVQLDELYNQLHRLYFQGLKYSQDLLQLFNTFMAEDIENVGAPDDICIFASCFDDIYTLYSAFDELNSQYMEFCQISKSSLDQISFKDANIETKQLKKLPELVDNCNIMILRSIAILNRFIDWNIEVNGFFQFQKKRLLNLQKVIYST
SIO_010081: YLL049W
subclass of: SO_0000673
so part of: YLL049W
location: 40666..41205
location: region:40666-41205:1
so has part: feature:40666-41205:1:exon

NP_013051.1
type: Protein
SIO_000068: ncbiprotein

S000003972
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40666-41205:1:exon

YLL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BAT1
gene: YBT1
locus tag: YLL048C
gene synonym: BAT1
so part of: sequence
location: complement(<41280..>46265)
location: region:41280-46265:-1
so has part: feature:41280-46265:-1:exon
subclass of: SO_0000010

850678
type: Gene
SIO_000068: ncbigene

position:41280:-1
position: 41280
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:46265:-1
position: 46265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:41280-46265:-1:exon

YLL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BAT1
gene: YBT1
locus tag: YLL048C
gene synonym: BAT1
product: bile acid-transporting ATPase YBT1
transcript id: NM_001181868.1
SIO_010081: YLL048C
subclass of: SO_0000673
so part of: YLL048C
location: complement(<41280..>46265)
location: region:41280-46265:-1
so has part: feature:41280-46265:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:41280-46265:-1:exon

YLL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BAT1
gene: YBT1
locus tag: YLL048C
gene synonym: BAT1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9182565]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]
experiment: EXISTENCE:mutant phenotype:GO:0015718 monocarboxylic acid transport [PMID:9182565]
experiment: EXISTENCE:mutant phenotype:GO:0033285 ATPase-coupled monocarboxylic acid transmembrane transporter activity [PMID:9182565]
note: Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication
codon start: 1
product: bile acid-transporting ATPase YBT1
translation: MHHVLNSTRPDHRFWFYDDVTQYGRTKYLNYYTPLVLLIFTVLFITYNIWKHYYYYDVLHLKQKNPIDELLYSSTDEDEQSPLINNNTITTNYVDNNCTKDALKNRHFSLEKLKSVKVNGEPHGTPEIVRRGFIEKSRIILEFFLVLSQVIIHSFILLHYVNKNPEFTQQGTITGLVEWCALFIIVSLRLANVNQNFKFINKYPGNLWSVSFINYLALFISMILPFRSIFIHHINSPISRKYYISQISINLALFLLLFFARIRNNFAIIYKTDSWITPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVKRKRIFSLNLFFFFSNYLVLQCFWAFLGSVLSFIPTVLLKRILEYVEDQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGLFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCEHSGELDILIELAKKAFVEKLNSKKD
SIO_010081: YLL048C
subclass of: SO_0000673
so part of: YLL048C
location: complement(41280..46265)
location: region:41280-46265:-1
so has part: feature:41280-46265:-1:exon

NP_013052.1
type: Protein
SIO_000068: ncbiprotein

S000003971
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:41280-46265:-1:exon

YLL046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RNP1
locus tag: YLL046C
so part of: sequence
location: complement(<46714..>47463)
location: region:46714-47463:-1
so has part: feature:46714-47463:-1:exon
subclass of: SO_0000010

850680
type: Gene
SIO_000068: ncbigene

position:46714:-1
position: 46714
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:47463:-1
position: 47463
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:46714-47463:-1:exon

YLL046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RNP1
locus tag: YLL046C
product: Rnp1p
transcript id: NM_001181866.1
SIO_010081: YLL046C
subclass of: SO_0000673
so part of: YLL046C
location: complement(<46714..>47463)
location: region:46714-47463:-1
so has part: feature:46714-47463:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:46714-47463:-1:exon

YLL046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RNP1
locus tag: YLL046C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8341595]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:8341595]
note: Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication
codon start: 1
product: Rnp1p
translation: MLIEEIEFYNVNGKKTTTVVPENTKIKKRVLNDRRTLYVGNLPKNCRKQDLRDLFEPNYGKITINMLKKKPLKKPLKRFAFIEFQEGVNLKKVKEKMNGKIFMNEKIVIENILTKEEKSFEKNQKSNKKTAPDLKPLSTNTLYVKNIPMKSTNEDLAKIFGVDPKNINFVRRELVDLRTNKVFFSDEFHTGEAFIKFDNLGTGDSIQKKCREFKGRKASNGRVLLVKIASAKKNEQKQEGGDNTKIKQN
SIO_010081: YLL046C
subclass of: SO_0000673
so part of: YLL046C
location: complement(46714..47463)
location: region:46714-47463:-1
so has part: feature:46714-47463:-1:exon

NP_013054.1
type: Protein
SIO_000068: ncbiprotein

S000003969
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:46714-47463:-1:exon

YLL045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KRB1
alternative label: SCL41
gene: RPL8B
locus tag: YLL045C
gene synonym: KRB1; SCL41
so part of: sequence
location: complement(<47859..>48629)
location: region:47859-48629:-1
so has part: feature:47859-48629:-1:exon
subclass of: SO_0000010

850682
type: Gene
SIO_000068: ncbigene

position:47859:-1
position: 47859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48629:-1
position: 48629
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:47859-48629:-1:exon

YLL045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KRB1
alternative label: SCL41
gene: RPL8B
locus tag: YLL045C
gene synonym: KRB1; SCL41
product: ribosomal 60S subunit protein L8B
transcript id: NM_001181865.1
SIO_010081: YLL045C
subclass of: SO_0000673
so part of: YLL045C
location: complement(<47859..>48629)
location: region:47859-48629:-1
so has part: feature:47859-48629:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:47859-48629:-1:exon

YLL045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KRB1
alternative label: SCL41
gene: RPL8B
locus tag: YLL045C
gene synonym: KRB1; SCL41
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]
note: Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog
codon start: 1
product: ribosomal 60S subunit protein L8B
translation: MAPGKKVAPAPFGAKSTKSNKAKNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAIAEGKSKQDASPKPYAVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIIKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKTSDSA
SIO_010081: YLL045C
subclass of: SO_0000673
so part of: YLL045C
location: complement(47859..48629)
location: region:47859-48629:-1
so has part: feature:47859-48629:-1:exon

NP_013055.1
type: Protein
SIO_000068: ncbiprotein

S000003968
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:47859-48629:-1:exon

YLL043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FPS1
locus tag: YLL043W
so part of: sequence
location: <49938..>51947
location: region:49938-51947:1
so has part: feature:49938-51947:1:exon
subclass of: SO_0000010

850683
type: Gene
SIO_000068: ncbigene

position:49938:1
position: 49938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:51947:1
position: 51947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:49938-51947:1:exon

YLL043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FPS1
locus tag: YLL043W
product: Fps1p
transcript id: NM_001181863.1
SIO_010081: YLL043W
subclass of: SO_0000673
so part of: YLL043W
location: <49938..>51947
location: region:49938-51947:1
so has part: feature:49938-51947:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:49938-51947:1:exon

YLL043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FPS1
locus tag: YLL043W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20026328|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0015168 glycerol transmembrane transporter activity [PMID:12486125|PMID:7729414|PMID:8550015]
experiment: EXISTENCE:direct assay:GO:0015793 glycerol transmembrane transport [PMID:12486125]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:9281576]
experiment: EXISTENCE:mutant phenotype:GO:0006846 acetate transport [PMID:17620418]
experiment: EXISTENCE:mutant phenotype:GO:0015168 glycerol transmembrane transporter activity [PMID:7729414|PMID:8550015]
experiment: EXISTENCE:mutant phenotype:GO:0015254 glycerol channel activity [PMID:22593571]
experiment: EXISTENCE:mutant phenotype:GO:0015700 arsenite transport [PMID:20026328]
experiment: EXISTENCE:mutant phenotype:GO:0015791 polyol transmembrane transport [PMID:23475614]
experiment: EXISTENCE:mutant phenotype:GO:0015793 glycerol transmembrane transport [PMID:22593571|PMID:23475614]
note: Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state
codon start: 1
product: Fps1p
translation: MSNPQKALNDFLSSESVHTHDSSRKQSNKQSSDEGRSSSQPSHHHSGGTNNNNNNNNNNNNSNNNNNGNDGGNDDDYDYEMQDYRPSPQSARPTPTYVPQYSVESGTAFPIQEVIPSAYINTQDINHKDNGPPSASSNRAFRPRGQTTVSANVLNIEDFYKNADDAHTIPESHLSRRRSRSRATSNAGHSANTGATNGRTTGAQTNMESNESPRNVPIMVKPKTLYQNPQTPTVLPSTYHPINKWSSVKNTYLKEFLAEFMGTMVMIIFGSAVVCQVNVAGKIQQDNFNVALDNLNVTGSSAETIDAMKSLTSLVSSVAGGTFDDVALGWAAAVVMGYFCAGGSAISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVLQEAYSDWWMNESVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVNWSLPVYKEMIMRAWFRRPGWKKRNRARRTSDLSDFSYNNDDDEEFGERMALQKTKTKSSISDNENEAGEKKVQFKSVQRGKRTFGGIPTILEEEDSIETASLGATTTDSIGLSDTSSEDSHYGNAKKVT
SIO_010081: YLL043W
subclass of: SO_0000673
so part of: YLL043W
location: 49938..51947
location: region:49938-51947:1
so has part: feature:49938-51947:1:exon

NP_013057.1
type: Protein
SIO_000068: ncbiprotein

S000003966
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:49938-51947:1:exon

YLL042C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG10
gene: ATG10
locus tag: YLL042C
gene synonym: APG10
so part of: sequence
location: complement(<52087..>52590)
location: region:52087-52590:-1
so has part: feature:52087-52590:-1:exon
subclass of: SO_0000010

850684
type: Gene
SIO_000068: ncbigene

position:52087:-1
position: 52087
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52590:-1
position: 52590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52087-52590:-1:exon

YLL042C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG10
gene: ATG10
locus tag: YLL042C
gene synonym: APG10
product: E2-like conjugating enzyme
transcript id: NM_001181862.1
SIO_010081: YLL042C
subclass of: SO_0000673
so part of: YLL042C
location: complement(<52087..>52590)
location: region:52087-52590:-1
so has part: feature:52087-52590:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:52087-52590:-1:exon

YLL042C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG10
gene: ATG10
locus tag: YLL042C
gene synonym: APG10
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:10508157]
experiment: EXISTENCE:mutant phenotype:GO:0019777 Atg12 transferase activity [PMID:10508157]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10508157]
experiment: EXISTENCE:mutant phenotype:GO:0032446 protein modification by small protein conjugation [PMID:10508157|PMID:9759731]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:physical interaction:GO:0032446 protein modification by small protein conjugation [PMID:10508157]
note: Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
codon start: 1
product: E2-like conjugating enzyme
translation: MIPYQEWHSQLQSLYDSQIFHNWALCQDVHLNDEKDGLLLRLIPTRQLQKNTERIENKLLNHIELYLTYSKVYNEPLLLLRIWEEKSIDGIPMTKLMLPTDIESLLDVQGKFQLGLDTIINLEGSVWYSFHPCDTSCIVGDQAEFMSTYLRRWVSIFIFSWLGYEDS
SIO_010081: YLL042C
subclass of: SO_0000673
so part of: YLL042C
location: complement(52087..52590)
location: region:52087-52590:-1
so has part: feature:52087-52590:-1:exon

NP_013058.1
type: Protein
SIO_000068: ncbiprotein

S000003965
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52087-52590:-1:exon

YLL041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACN17
gene: SDH2
locus tag: YLL041C
gene synonym: ACN17
so part of: sequence
location: complement(<53131..>53931)
location: region:53131-53931:-1
so has part: feature:53131-53931:-1:exon
subclass of: SO_0000010

850685
type: Gene
SIO_000068: ncbigene

position:53131:-1
position: 53131
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:53931:-1
position: 53931
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53131-53931:-1:exon

YLL041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACN17
gene: SDH2
locus tag: YLL041C
gene synonym: ACN17
product: succinate dehydrogenase iron-sulfur protein subunit SDH2
transcript id: NM_001181861.1
SIO_010081: YLL041C
subclass of: SO_0000673
so part of: YLL041C
location: complement(<53131..>53931)
location: region:53131-53931:-1
so has part: feature:53131-53931:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53131-53931:-1:exon

YLL041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACN17
gene: SDH2
locus tag: YLL041C
gene synonym: ACN17
EC number: 1.3.5.1
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23509072]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [PMID:9822678]
experiment: EXISTENCE:direct assay:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:13445213]
experiment: EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:1939170]
experiment: EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:16232921]
experiment: EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:16232921]
experiment: EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:10224250]
experiment: EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:16232921]
experiment: EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]
note: Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p
codon start: 1
product: succinate dehydrogenase iron-sulfur protein subunit SDH2
translation: MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA
SIO_010081: YLL041C
subclass of: SO_0000673
so part of: YLL041C
location: complement(53131..53931)
location: region:53131-53931:-1
so has part: feature:53131-53931:-1:exon

NP_013059.1
type: Protein
SIO_000068: ncbiprotein

S000003964
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53131-53931:-1:exon

YLL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SOI1
alternative label: VPT2
gene: VPS13
locus tag: YLL040C
gene synonym: SOI1; VPT2
so part of: sequence
location: complement(<54211..>63645)
location: region:54211-63645:-1
so has part: feature:54211-63645:-1:exon
subclass of: SO_0000010

850619
type: Gene
SIO_000068: ncbigene

position:54211:-1
position: 54211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:63645:-1
position: 63645
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54211-63645:-1:exon

YLL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SOI1
alternative label: VPT2
gene: VPS13
locus tag: YLL040C
gene synonym: SOI1; VPT2
product: membrane morphogenesis protein VPS13
transcript id: NM_001181860.1
SIO_010081: YLL040C
subclass of: SO_0000673
so part of: YLL040C
location: complement(<54211..>63645)
location: region:54211-63645:-1
so has part: feature:54211-63645:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54211-63645:-1:exon

YLL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SOI1
alternative label: VPT2
gene: VPS13
locus tag: YLL040C
gene synonym: SOI1; VPT2
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:28122955]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:22442115|PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:32690699]
experiment: EXISTENCE:direct assay:GO:0006895 Golgi to endosome transport [PMID:28122955]
experiment: EXISTENCE:direct assay:GO:0044232 organelle membrane contact site [PMID:27280386]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26370498]
experiment: EXISTENCE:direct assay:GO:0090083 regulation of inclusion body assembly [PMID:31433985]
experiment: EXISTENCE:direct assay:GO:0120009 intermembrane lipid transfer [PMID:30093493]
experiment: EXISTENCE:direct assay:GO:0120014 phospholipid transfer activity [PMID:30093493]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:26370498]
experiment: EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:26370498]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8887651]
experiment: EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:32690699]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:22442115|PMID:26605945]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:9314526]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9265642]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:32690699]
note: Lipid transport protein; involved in vacuolar protein sorting, protein retention in the Golgi, prospore membrane formation and sporulation; required for mitochondrial integrity and ER packaging into autophagosomes during cortical reticulophagy; peripheral membrane protein found at the prospore membrane and at membrane contact sites; contains a PH-like domain; homologous to human CHAC and COH1, involved in Chorea-acanthocytosis and Cohen syndrome, respectively
codon start: 1
product: membrane morphogenesis protein VPS13
translation: MLESLAANLLNRLLGSYVENFDPNQLNVGIWSGDVKLKNLKLRKDCLDSLNLPIDVKSGILGDLVLTVPWSSLKNKPVKIIIEDCYLLCSPRSEDHENDEEMIKRAFRLKMRKVSEWELTNQARILSTQSENKTSSSSSEKNNAGFMQSLTTKIIDNLQVTIKNIHLRYEDMDGIFTTGPSSVGLTLNELSAVSTDSNWAPSFIDITQNITHKLLTLNSLCLYWNTDSPPLISDDDQDRSLENFVRGFKDMIASKNSTAPKHQYILKPVSGLGKLSINKLGSTEEQPHIDLQMFYDEFGLELDDTEYNDILHVLSSIQLRQITKKFKKARPSFAVSENPTEWFKYIAACVINEIHEKNKMWTWESMKEKCEQRRLYTKLWVEKLKLKNLEAPLRDPIQEAQLSELHKDLTYDEIILFRSVAKRQYAQYKLGMTEDSPTPTASSNIEPQTSNKSATKNNGSWLSSWWNGKPTEEVDEDLIMTEEQRQELYDAIEFDENEDKGPVLQVPRERVELRVTSLLKKGSFTIRKKKQNLNLGSIIFENCKVDFAQRPDSFLSSFQLNKFSLEDGSPNALYKHIISVRNSSKDQSSIDNHATGEEEEEDEPLLRASFELNPLDGLADSNLNIKLLGMTVFYHVHFITEVHKFFKASNQHMETIGNIVNAAEATVEGWTTQTRMGIESLLEDHKTVNVSLDLQAPLIILPLDPHDWDTPCAIIDAGHMSILSDLVPKEKIKEIKELSPEEYDKIDGNEINRLMFDRFQILSQDTQIFVGPDIQSTIGKINTASSTNDFRILDKMKLELTVDLSILPKAYKLPTIRVFGHLPRLSLSINDIQYKTIMNLIANSIPSMIDDEENNGDYVNYSSGSEKEMKKQIQLQLKNTLKALENMQPLQIEQKFLELHFDIDQAKIAFFQCIKNDSRNSEKLVDILCQRLNFNFDKRAKEMNLDLRVHSLDVEDYIELTDNKEFKNLISSGVEKVTRSQKDLFTLKYKRVQRIVPHNDTLIELFDQDIVMHMSELQLVLTPRSVLTLMNYAMLTFTDPNAPEMPADVLRHNKEDRDDAPQKINMKIKMEAVNVIFNDDSIKLATLVLSAGEFTMVLLPERYNINLKLGGLELTDETNESFSRDSVFRKIIQMKGQELVELSYESFDPATNTKDYDSFLKYSTGSMHVNFIESAVNRMVNFFAKFQKSKVSFDRARLAAYNQAPSIDAVNNMKMDIVIKAPIIQFPKLVGTQENNYDTMRFYLGEFFIENKFSVIDESHKINHIKLGVREGQLSSNLNFDGSSQQLYLVENIGLLFNIDRDPLPQDDTPELKVTSNFESFALDLTENQLTYLLEISNKVSSAFNITDENSGESGGKGEIKSPSPDPASLSSESERTATPQSLQGSNKSNIKNPEQKYLDFSFKAPKIALTLYNKTKGVTSLNDCGLTRIMFQDIGCSLGLKNDGTVDGQAHVAAFRIEDVRNIKDNKHTELIPKSKNKEYQFVANISRKNLEVGRLLNISMTMDSPKMILAMDYLVSLKEFFDAIMSKSHENNLYYPENTNQKPENKAIVESVQEGGDVTKIQYSVNIIETALILLADPCDMNSEAISFKIGQFLVTDQNIMTVAANNVGIFLFKMNSSEEKLRLLDDFSSSLTIDKRNSTPQTLMTNIQLSVQPLLMRISLRDIRLAMLIFKRVTTLLNKMTEKEDNGEEEESTDKIQFSHEFERKLAVLDPSILGERSRASQSSDSESIEVPTAILKNETFNADLGGLRFILIGDVHEMPILDMNVNEITASAKDWSTDFEALASLETYVNIFNYSRSSWEPLLEMIPITFHLSKGHSEMDPAFSFDILTQRIAEITLSARSIAMLSHIPASLTEELPLASRVSQKPYQLVNDTELDFDVWIQDKTTEDNKNEVVLLKANTSLPWEFEDWRSIREKLDIDKSKNILGVCVSGQNYKTIMNIDATTEGENLHVLSPPRNNVHNRIVCEARCDENNVKIITFRSTLVIENTTSTEIELL…
SIO_010081: YLL040C
subclass of: SO_0000673
so part of: YLL040C
location: complement(54211..63645)
location: region:54211-63645:-1
so has part: feature:54211-63645:-1:exon

NP_013060.1
type: Protein
SIO_000068: ncbiprotein

S000003963
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54211-63645:-1:exon

YLL039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCD2
alternative label: UB14
gene: UBI4
locus tag: YLL039C
gene synonym: SCD2; UB14
so part of: sequence
location: complement(<64062..>65207)
location: region:64062-65207:-1
so has part: feature:64062-65207:-1:exon
subclass of: SO_0000010

850620
type: Gene
SIO_000068: ncbigene

position:64062:-1
position: 64062
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65207:-1
position: 65207
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64062-65207:-1:exon

YLL039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCD2
alternative label: UB14
gene: UBI4
locus tag: YLL039C
gene synonym: SCD2; UB14
product: ubiquitin
transcript id: NM_001181859.1
SIO_010081: YLL039C
subclass of: SO_0000673
so part of: YLL039C
location: complement(<64062..>65207)
location: region:64062-65207:-1
so has part: feature:64062-65207:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:64062-65207:-1:exon

YLL039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCD2
alternative label: UB14
gene: UBI4
locus tag: YLL039C
gene synonym: SCD2; UB14
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22375831]
experiment: EXISTENCE:direct assay:GO:0031386 protein tag [PMID:3038523]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8035826]
note: Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via ubiquitin-26S proteasome system; essential for cellular stress response; encoded as polyubiquitin precursor comprised of 5 head-to-tail repeats; number of repeats is evolutionarily unstable within and between yeast species; protein abundance increases in response to DNA replication stress; implicated as modulator of replicative lifespan and meiotic recombination
codon start: 1
product: ubiquitin
translation: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGN
SIO_010081: YLL039C
subclass of: SO_0000673
so part of: YLL039C
location: complement(64062..65207)
location: region:64062-65207:-1
so has part: feature:64062-65207:-1:exon

NP_013061.1
type: Protein
SIO_000068: ncbiprotein

S000003962
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:64062-65207:-1:exon

YLL038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENT4
locus tag: YLL038C
so part of: sequence
location: complement(<65775..>66518)
location: region:65775-66518:-1
so has part: feature:65775-66518:-1:exon
subclass of: SO_0000010

850621
type: Gene
SIO_000068: ncbigene

position:65775:-1
position: 65775
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:66518:-1
position: 66518
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:65775-66518:-1:exon

YLL038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENT4
locus tag: YLL038C
product: Ent4p
transcript id: NM_001181858.1
SIO_010081: YLL038C
subclass of: SO_0000673
so part of: YLL038C
location: complement(<65775..>66518)
location: region:65775-66518:-1
so has part: feature:65775-66518:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:65775-66518:-1:exon

YLL038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENT4
locus tag: YLL038C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:19574226]
note: hypothetical protein; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
codon start: 1
product: Ent4p
translation: MPLLDTFKSFIQSPTESKVKQATNEDETSGATGTLMNEISILTYSPKTVREIIQVIRKRLLLGQNRRNSHRNCIQVMKTLTLVSYLMNNGSNEFIKWLKGNMILIEILEDFQVQDPRDERKAEDIQKLSRNVLGLLQDDGLLEKQRKDVIQFRSSISTPGRKSTDNSHLKLEEMRSELTRQSLEKKAKPPTTSTSLDFQRQRTRNTHEYARFSLDPLAEEDSEDTPGVAGGISKLSFRPKSSNNPFR
SIO_010081: YLL038C
subclass of: SO_0000673
so part of: YLL038C
location: complement(65775..66518)
location: region:65775-66518:-1
so has part: feature:65775-66518:-1:exon

NP_013062.1
type: Protein
SIO_000068: ncbiprotein

S000003961
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:65775-66518:-1:exon

YLL036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSO4
gene: PRP19
locus tag: YLL036C
gene synonym: PSO4
so part of: sequence
location: complement(<66745..>68256)
location: region:66745-68256:-1
so has part: feature:66745-68256:-1:exon
subclass of: SO_0000010

850623
type: Gene
SIO_000068: ncbigene

position:66745:-1
position: 66745
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:68256:-1
position: 68256
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:66745-68256:-1:exon

YLL036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSO4
gene: PRP19
locus tag: YLL036C
gene synonym: PSO4
product: E3 ubiquitin-protein ligase PRP19
transcript id: NM_001181856.1
SIO_010081: YLL036C
subclass of: SO_0000673
so part of: YLL036C
location: complement(<66745..>68256)
location: region:66745-68256:-1
so has part: feature:66745-68256:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:66745-68256:-1:exon

YLL036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSO4
gene: PRP19
locus tag: YLL036C
gene synonym: PSO4
EC number: 2.3.2.27
experiment: EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:8248176]
experiment: EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:8194532]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12627222]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:8248176]
experiment: EXISTENCE:mutant phenotype:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:12970570]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:12627222]
note: Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: E3 ubiquitin-protein ligase PRP19
translation: MLCAISGKVPRRPVLSPKSRTIFEKSLLEQYVKDTGNDPITNEPLSIEEIVEIVPSAQQASLTESTNSATLKANYSIPNLLTSLQNEWDAIMLENFKLRSTLDSLTKKLSTVMYERDAAKLVAAQLLMEKNEDSKDLPKSSQQAVAITREEFLQGLLQSSRDFVARGKLKAPKWPILKNLELLQAQNYSRNIKTFPYKELNKSMYYDKWVCMCRCEDGALHFTQLKDSKTITTITTPNPRTGGEHPAIISRGPCNRLLLLYPGNQITILDSKTNKVLREIEVDSANEIIYMYGHNEVNTEYFIWADNRGTIGFQSYEDDSQYIVHSAKSDVEYSSGVLHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVECDQTVVCFDLRKDVGTLAYPTYTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQSDTADFTDMDVVCGDGGIAAILKTNDSFNIVALTP
SIO_010081: YLL036C
subclass of: SO_0000673
so part of: YLL036C
location: complement(66745..68256)
location: region:66745-68256:-1
so has part: feature:66745-68256:-1:exon

NP_013064.1
type: Protein
SIO_000068: ncbiprotein

S000003959
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:66745-68256:-1:exon

YLL035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRC3
locus tag: YLL035W
so part of: sequence
location: <68580..>70478
location: region:68580-70478:1
so has part: feature:68580-70478:1:exon
subclass of: SO_0000010

850624
type: Gene
SIO_000068: ncbigene

position:68580:1
position: 68580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70478:1
position: 70478
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:68580-70478:1:exon

YLL035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRC3
locus tag: YLL035W
product: polynucleotide 5'-hydroxyl-kinase
transcript id: NM_001181855.1
SIO_010081: YLL035W
subclass of: SO_0000673
so part of: YLL035W
location: <68580..>70478
location: region:68580-70478:1
so has part: feature:68580-70478:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:68580-70478:1:exon

YLL035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRC3
locus tag: YLL035W
experiment: EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]
experiment: EXISTENCE:direct assay:GO:0051731 polynucleotide 5'-hydroxyl-kinase activity [PMID:20814424]
experiment: EXISTENCE:mutant phenotype:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23175604]
experiment: EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:20814424]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]
experiment: EXISTENCE:physical interaction:GO:0030874 nucleolar chromatin [PMID:20814424]
note: Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated
codon start: 1
product: polynucleotide 5'-hydroxyl-kinase
translation: MVIDSKQDLPQYTKDSGSESDSDSSNNFIVESPSIPSSKSATVVLNSEEYEDDEGDDLNGLDAELIDNITYEGDEDETMFVGLKEKQKLHLSGVFRLQVVKGGIVYNNVHYNASREILTFWHPLSQSIPTIDFSHFAGWQDTFFMPRNNRFKIRDEEFKSFPCVLRVFNSNHTGLLEAGHLYRDVNYLWKPKEPYFPLNERTTYHLLHESDRIQSLSVPGYWSTPLEKLYLSHKNAAYDTRIMVIGGKNSGKSTFLRLLLEKFTQDIRDSTTSQEELVYLDLDPGQPEYSLPDSISLNKILSSPISLGQHLCQGSNFQTLLQFYAGSSSPQDEPTSYLNCADKLIDHLEEQAFFGTSLLNLPGWIKGFGMQILNHIIRKYKPTHLLFLETANSKRHLDELTIPQSFSTSLRDAYAPEVVRVPAHSLNHTLSSRFHASQLRTFKILALFHKITQFDYDFAPLLKSAPLQISYGKGKSGIKGIQFPMEFQDLNPQDIKSALEGTVIGIYTYSGEDSLEVKSLNTFPILQSCTSSSKNFITLGLIHSIDTSQQIMNIYVPPCHTQILDKQPEDAQWIIVRNKTETPFCDFLPSPRTITWDDNIQIPFATFERRKKLEHVWKVRKNVMRRGQFMKR
SIO_010081: YLL035W
subclass of: SO_0000673
so part of: YLL035W
location: 68580..70478
location: region:68580-70478:1
so has part: feature:68580-70478:1:exon

NP_013065.1
type: Protein
SIO_000068: ncbiprotein

S000003958
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:68580-70478:1:exon

YLL034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIX7
locus tag: YLL034C
so part of: sequence
location: complement(<70633..>73146)
location: region:70633-73146:-1
so has part: feature:70633-73146:-1:exon
subclass of: SO_0000010

850625
type: Gene
SIO_000068: ncbigene

position:70633:-1
position: 70633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73146:-1
position: 73146
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70633-73146:-1:exon

YLL034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIX7
locus tag: YLL034C
product: putative AAA family ATPase RIX7
transcript id: NM_001181854.1
SIO_010081: YLL034C
subclass of: SO_0000673
so part of: YLL034C
location: complement(<70633..>73146)
location: region:70633-73146:-1
so has part: feature:70633-73146:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70633-73146:-1:exon

YLL034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIX7
locus tag: YLL034C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11447111|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11447111|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:18559667]
experiment: EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:18559667]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11447111]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:18559667]
note: Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
codon start: 1
product: putative AAA family ATPase RIX7
translation: MVKVKSKKNSLTSSLDNKIVDLIYRLLEEKTLDRKRSLRQESQGEEGENNEGEEDEDIFESMFFAKDLTAGEIFTFCLTKDLSLQRVKKVVLQKTIDRMLKDVIESELEEFGSYPGYNNEEEEKPSLEEELAKKNMMIERDTNEMNKRITSTWSKSGSVSESITETDDPKTEEVKKSKKRSKEGTCKVKRQKIKEDRSPPNSSLKSLGGMDDVVAQLMELIGLPILHPEIFLSTGVEPPRGVLLHGPPGCGKTSIANALAGELQVPFISISAPSVVSGMSGESEKKIRDLFDEARSLAPCLVFFDEIDAITPKRDGGAQREMERRIVAQLLTSMDELTMEKTNGKPVIIIGATNRPDSLDAALRRAGRFDREICLNVPNEVSRLHILKKMSDNLKIDGAIDFAKLAKLTPGFVGADLKALVTAAGTCAIKRIFQTYANIKSTPTTATDSSEDNMEIDETANGDESSLKNTANMIDPLPLSVVQQFIRNYPEPLSGEQLSLLSIKYEDFLKALPTIQPTAKREGFATVPDVTWANVGALQRVRLELNMAIVQPIKRPELYEKVGISAPGGVLLWGPPGCGKTLLAKAVANESRANFISIKGPELLNKYVGESERSIRQVFTRARASVPCVIFFDELDALVPRRDTSLSESSSRVVNTLLTELDGLNDRRGIFVIGATNRPDMIDPAMLRPGRLDKSLFIELPNTEEKLDIIKTLTKSHGTPLSSDVDFEEIIRNEKCNNFSGADLAALVRESSVLALKRKFFQSEEIQSVLDNDLDKEFEDLSVGVSGEEIIVTMSDFRSALRKIKPSVSDKDRLKYDRLNKKMGLTEEMKDAEEMKQ
SIO_010081: YLL034C
subclass of: SO_0000673
so part of: YLL034C
location: complement(70633..73146)
location: region:70633-73146:-1
so has part: feature:70633-73146:-1:exon

NP_013066.1
type: Protein
SIO_000068: ncbiprotein

S000003957
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70633-73146:-1:exon

YLL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRG4
gene: IRC19
locus tag: YLL033W
gene synonym: RRG4
so part of: sequence
location: <73409..>74101
location: region:73409-74101:1
so has part: feature:73409-74101:1:exon
subclass of: SO_0000010

850626
type: Gene
SIO_000068: ncbigene

position:73409:1
position: 73409
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:74101:1
position: 74101
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:73409-74101:1:exon

YLL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRG4
gene: IRC19
locus tag: YLL033W
gene synonym: RRG4
product: Irc19p
transcript id: NM_001181853.1
SIO_010081: YLL033W
subclass of: SO_0000673
so part of: YLL033W
location: <73409..>74101
location: region:73409-74101:1
so has part: feature:73409-74101:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:73409-74101:1:exon

YLL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRG4
gene: IRC19
locus tag: YLL033W
gene synonym: RRG4
experiment: EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12432101]
note: hypothetical protein; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
codon start: 1
product: Irc19p
translation: MRKPSITITTAKAIITPDYTLIKSHSKYQLPSRFQKLDADSPERSTVVKLFYRRFMRLKPFISNVKMVKDTYRDYVRYKFMKENYELKRYLVFNPDGLRSKINLELLSNTKCCERILPVTEMQRTLEFVLKSCSYLPETKVQKWDIARDNTYCRQILKNLLTMQYEKYRSILHRGIGHDELDVKFSHLKTTSSPLTKLNKTEKKKIPLFKVFSDFDTTLIYLNETLGTRL
SIO_010081: YLL033W
subclass of: SO_0000673
so part of: YLL033W
location: 73409..74101
location: region:73409-74101:1
so has part: feature:73409-74101:1:exon

NP_013067.1
type: Protein
SIO_000068: ncbiprotein

S000003956
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73409-74101:1:exon

YLL032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL032C
so part of: sequence
location: complement(<74270..>76747)
location: region:74270-76747:-1
so has part: feature:74270-76747:-1:exon
subclass of: SO_0000010

850627
type: Gene
SIO_000068: ncbigene

position:74270:-1
position: 74270
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:76747:-1
position: 76747
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74270-76747:-1:exon

YLL032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL032C
product: uncharacterized protein
transcript id: NM_001181852.1
SIO_010081: YLL032C
subclass of: SO_0000673
so part of: YLL032C
location: complement(<74270..>76747)
location: region:74270-76747:-1
so has part: feature:74270-76747:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74270-76747:-1:exon

YLL032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL032C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MDNFKIYSTVITTAFLQVPHLYTTNRLWKPIEAPFLVEFLQKRISSKELKNTKAICHIDPSWVNLNASFIRDDMISIKATTDDMDLDAICRISLPLPMNTNDLTAELEKMKRILLDLSEKFNLELIITKEPAYFTPEQTGESKELCIYVHALGFRSNLMECEPQLLAFVDLIKKNGMTLPPQHYIIEPMELNSYSVLPLYMGVDMENFKHISRAFKTSIYAPSLITLSRDLKANPQIFFSGAVHSLSLLARKTLRESISVNSKSFFYRRLTNITPGKLLFIRKYYQQKVNQLILKYQSLIRVTNEYIEFQSISTNLLEMVIKNFTIQVLHEIVEVQISLNENCAMSPELIIDSFFGHTGNQIVVITPKEDSFNQLIVVGNQSSTDEASDTSILHYLSDFIMGSNQVINPNLRQIKAIFEIHPDFEDFISGKKNGKLTRIMELSACLIQLEMEEEDDNLYLNLVSDSFPDFKESFKNVINEFPAEESFFIPEVCHRPIIGTGGSLIQATMRKHNVFIQFSNSFNLPQNKISMIRYDNVIIRCPRKNKANICLAKNDLKQIVQEYDSLQSKTLIRFSSGQYRHILHVNGQKNIIGQIEKNENVYIMIPLKEPLDGTSQLSIQGNDENASRAANELVNSAFGYEYEFKIDQEIDPNKEYEFYNLIVVPFLQIMNIIVTFEKDLITFTFEKDTNENTLTKAIELLSNYLETQKTKIIFKKIIKKFVLGSASSKSNTSNSNTNGNFRSMNNAKSRTTIDNTSQSGASPQRHKMPVITTVGGAQAIKGYIPNTYYNGYGYGYGYTYEYDYNYANSNKAQTNNRHKYQNGRK
SIO_010081: YLL032C
subclass of: SO_0000673
so part of: YLL032C
location: complement(74270..76747)
location: region:74270-76747:-1
so has part: feature:74270-76747:-1:exon

NP_013068.1
type: Protein
SIO_000068: ncbiprotein

S000003955
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74270-76747:-1:exon

YLL031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPC1
gene: GPI13
locus tag: YLL031C
gene synonym: MPC1
so part of: sequence
location: complement(<77152..>80205)
location: region:77152-80205:-1
so has part: feature:77152-80205:-1:exon
subclass of: SO_0000010

850628
type: Gene
SIO_000068: ncbigene

position:77152:-1
position: 77152
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80205:-1
position: 80205
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77152-80205:-1:exon

YLL031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPC1
gene: GPI13
locus tag: YLL031C
gene synonym: MPC1
product: mannose-ethanolamine phosphotransferase GPI13
transcript id: NM_001181851.1
SIO_010081: YLL031C
subclass of: SO_0000673
so part of: YLL031C
location: complement(<77152..>80205)
location: region:77152-80205:-1
so has part: feature:77152-80205:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77152-80205:-1:exon

YLL031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPC1
gene: GPI13
locus tag: YLL031C
gene synonym: MPC1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:12441642|PMID:10793139]
experiment: EXISTENCE:mutant phenotype:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:10793139]
experiment: EXISTENCE:mutant phenotype:GO:0051377 mannose-ethanolamine phosphotransferase activity [PMID:12441642]
note: ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
codon start: 1
product: mannose-ethanolamine phosphotransferase GPI13
translation: MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWINVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLMGPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGTIAFASGRLIKHINDIFWK
SIO_010081: YLL031C
subclass of: SO_0000673
so part of: YLL031C
location: complement(77152..80205)
location: region:77152-80205:-1
so has part: feature:77152-80205:-1:exon

NP_013069.1
type: Protein
SIO_000068: ncbiprotein

S000003954
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77152-80205:-1:exon

YLL030C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRT7
locus tag: YLL030C
so part of: sequence
location: complement(<80356..>80697)
location: region:80356-80697:-1
so has part: feature:80356-80697:-1:exon
subclass of: SO_0000010

850629
type: Gene
SIO_000068: ncbigene

position:80356:-1
position: 80356
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80697:-1
position: 80697
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80356-80697:-1:exon

YLL030C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRT7
locus tag: YLL030C
product: Rrt7p
transcript id: NM_001348853.1
SIO_010081: YLL030C
subclass of: SO_0000673
so part of: YLL030C
location: complement(<80356..>80697)
location: region:80356-80697:-1
so has part: feature:80356-80697:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80356-80697:-1:exon

YLL030C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRT7
locus tag: YLL030C
note: hypothetical protein; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription
codon start: 1
product: Rrt7p
translation: MYFAFKGLCGRRFLPIASFLTILNRILFQYWLFYNSLKEEKTFQKIFFSMNLKCRKKKEPNHIIYSQPPFLLGFMVQLQSCVKLLPLYLLFLLQGNGAHYASAMTSKVLSFFL
SIO_010081: YLL030C
subclass of: SO_0000673
so part of: YLL030C
location: complement(80356..80697)
location: region:80356-80697:-1
so has part: feature:80356-80697:-1:exon

NP_001335793.1
type: Protein
SIO_000068: ncbiprotein

S000003953
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80356-80697:-1:exon

YLL029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRA1
locus tag: YLL029W
so part of: sequence
location: <81461..>83710
location: region:81461-83710:1
so has part: feature:81461-83710:1:exon
subclass of: SO_0000010

850630
type: Gene
SIO_000068: ncbigene

position:81461:1
position: 81461
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:83710:1
position: 83710
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81461-83710:1:exon

YLL029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRA1
locus tag: YLL029W
product: aminopeptidase P
transcript id: NM_001181849.1
SIO_010081: YLL029W
subclass of: SO_0000673
so part of: YLL029W
location: <81461..>83710
location: region:81461-83710:1
so has part: feature:81461-83710:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81461-83710:1:exon

YLL029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRA1
locus tag: YLL029W
EC number: 3.4.11.9
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]
note: Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
codon start: 1
product: aminopeptidase P
translation: MTSKPSTSDGRAHSISHVPGTHMRGTSASHSPRPFRPCADCTCSPGLLSRQGRRASLFLRQLENSRRSSSMLLNELKGAGGGSSAGNGSVYSCDSLCAVNREVNTTDRLLKLRQEMKKHDLCCYIVPSCDEHQSEYVSLRDQRRAFISGFSGSAGVACITRDLLNFNDDHPDGKSILSTDGRYFNQARQELDYNWTLLRQNEDPITWQEWCVREALEMAKGLGNKEGMVLKIGIDPKLITFNDYVSFRKMIDTKYDAKGKVELVPVEENLVDSIWPDFETLPERPCNDLLLLKYEFHGEEFKDKKEKLLKKLNDKASSATTGRNTFIVVALDEICWLLNLRGSDIDYNPVFFSYVAINEDETILFTNNPFNDDISEYFKINGIEVRPYEQIWEHLTKITSQASSAEHEFLIPDSASWQMVRCLNTSTNANGAIAKKMTAQNFAIIHSPIDVLKSIKNDIEIKNAHKAQVKDAVCLVQYFAWLEQQLVGREALIDEYRAAEKLTEIRKTQRNFMGNSFETISSTGSNAAIIHYSPPVENSSMIDPTKIYLCDSGSQFLEGTTDITRTIHLTKPTKEEMDNYTLVLKGGLALERLIFPENTPGFNIDAIARQFLWSRGLDYKHGTGHGIGSFLNVHEGPMGVGFRPHLMNFPLRAGNIISNEPGYYKDGEYGIRIESDMLIKKATEKGNFLKFENMTVVPYCRKLINTKLLNEEEKTQINEYHARVWRTIVHFLQPQSISYKWLKRETSPL
SIO_010081: YLL029W
subclass of: SO_0000673
so part of: YLL029W
location: 81461..83710
location: region:81461-83710:1
so has part: feature:81461-83710:1:exon

NP_013071.1
type: Protein
SIO_000068: ncbiprotein

S000003952
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81461-83710:1:exon

YLL028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPO1
locus tag: YLL028W
so part of: sequence
location: <84804..>86564
location: region:84804-86564:1
so has part: feature:84804-86564:1:exon
subclass of: SO_0000010

850631
type: Gene
SIO_000068: ncbigene

position:84804:1
position: 84804
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:86564:1
position: 86564
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84804-86564:1:exon

YLL028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPO1
locus tag: YLL028W
product: polyamine transporter TPO1
transcript id: NM_001181848.1
SIO_010081: YLL028W
subclass of: SO_0000673
so part of: YLL028W
location: <84804..>86564
location: region:84804-86564:1
so has part: feature:84804-86564:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84804-86564:1:exon

YLL028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPO1
locus tag: YLL028W
experiment: EXISTENCE:direct assay:GO:0000296 spermine transport [PMID:15637075]
experiment: EXISTENCE:direct assay:GO:0000297 spermine transmembrane transporter activity [PMID:15637075]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562762|PMID:15637075]
experiment: EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:15637075]
experiment: EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:15637075]
experiment: EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066|PMID:15637075|PMID:9920864]
experiment: EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066|PMID:15637075|PMID:9920864]
experiment: EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:15637075]
experiment: EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:11171066|PMID:15637075]
experiment: EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:9920864]
experiment: EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:11171066|PMID:15637075|PMID:9920864]
experiment: EXISTENCE:mutant phenotype:GO:1902047 polyamine transmembrane transport [PMID:24136413]
note: Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane
codon start: 1
product: polyamine transporter TPO1
translation: MSDHSPISNKENHLLPSDSSRSSSSDMHSTGTTGTTGVEPVDFTGEGAKYTTATEGNGGADLAIQRTTTMNSAAESEVNITRRLTKILTGSVNEPDRVEVDYTNCAPMGGDRPYPPSLPSRDLYEVTFDGPNDPLHPFNWPMKKKVLLCLVLCLDSIAIAMCSSIFASAVPQICEIYHVIEVVAILGITLFVLGFAASPVIYAPLSELYGRKGVLVLSAFGFALFQFAVATAENLQTIFICRFFGGFIGAAPMAVVPAAFADMFDTNVRGKAIALFSLGVFVGPILSPVMGSYIAQRTTWRWLEYVVGCFASAVFVAIVLFFEETHHPTILVNKAKQMRKQSNNWGIHAAHEDVELSIKDIVQKTVTRPIIMLFVEPLLLFVTIYNSFVYGILYLLLEAYPLVFVEGYGFTENGELPYIALIIGMMVCAAFIWYMDNDYLKRCRAKGKLVPEARLYAMVIAGTVFPIGILWFCWTGYYPHKIHWMVPTVGGAFIGFGLMGIFLPCLNYIIESYLLLAASAVAANTFMRSAFGACFPLFAGYMFRGMGIGWAGLLLGLFAAAMIPVPLLFLKYGESIRKKSKYAYAA
SIO_010081: YLL028W
subclass of: SO_0000673
so part of: YLL028W
location: 84804..86564
location: region:84804-86564:1
so has part: feature:84804-86564:1:exon

NP_013072.1
type: Protein
SIO_000068: ncbiprotein

S000003951
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84804-86564:1:exon

YLL027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ISA1
locus tag: YLL027W
so part of: sequence
location: <87403..>88155
location: region:87403-88155:1
so has part: feature:87403-88155:1:exon
subclass of: SO_0000010

850632
type: Gene
SIO_000068: ncbigene

position:87403:1
position: 87403
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:88155:1
position: 88155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87403-88155:1:exon

YLL027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ISA1
locus tag: YLL027W
product: Fe-binding Fe/S cluster assembly protein ISA1
transcript id: NM_001181847.1
SIO_010081: YLL027W
subclass of: SO_0000673
so part of: YLL027W
location: <87403..>88155
location: region:87403-88155:1
so has part: feature:87403-88155:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87403-88155:1:exon

YLL027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ISA1
locus tag: YLL027W
experiment: EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:21987576]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10805735]
experiment: EXISTENCE:genetic interaction:GO:0009102 biotin biosynthetic process [PMID:17259550]
experiment: EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:10805735]
experiment: EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:17259550]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10748136|PMID:10805735]
experiment: EXISTENCE:mutant phenotype:GO:0097428 protein maturation by iron-sulfur cluster transfer [PMID:12065597]
experiment: EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:21987576]
note: Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant
codon start: 1
product: Fe-binding Fe/S cluster assembly protein ISA1
translation: MINTGRSRNSVLLAHRFLSTGGFWRGGTNGTMSRTINNVNPFKLKFIPKTVPAAADSVSPDSQRPGKKPFKFIVSNQSKSSKASKSPKWSSYAFPSRETIKSHEEAIKKQNKAIDEQIAAAVSKNDCSCTEPPKKRKRKLRPRKALITLSPKAIKHLRALLAQPEPKLIRVSARNRGCSGLTYDLQYITEPGKFDEVVEQDGVKIVIDSKALFSIIGSEMDWIDDKLASKFVFKNPNSKGTCGCGESFMV
SIO_010081: YLL027W
subclass of: SO_0000673
so part of: YLL027W
location: 87403..88155
location: region:87403-88155:1
so has part: feature:87403-88155:1:exon

NP_013073.1
type: Protein
SIO_000068: ncbiprotein

S000003950
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87403-88155:1:exon

YLL026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HSP104
locus tag: YLL026W
so part of: sequence
location: <88623..>91349
location: region:88623-91349:1
so has part: feature:88623-91349:1:exon
subclass of: SO_0000010

850633
type: Gene
SIO_000068: ncbigene

position:88623:1
position: 88623
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:91349:1
position: 91349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:88623-91349:1:exon

YLL026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HSP104
locus tag: YLL026W
product: chaperone ATPase HSP104
transcript id: NM_001181846.1
SIO_010081: YLL026W
subclass of: SO_0000673
so part of: YLL026W
location: <88623..>91349
location: region:88623-91349:1
so has part: feature:88623-91349:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:88623-91349:1:exon

YLL026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HSP104
locus tag: YLL026W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10467108]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10467108|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16135516]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0035617 stress granule disassembly [PMID:24291094]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16135516]
experiment: EXISTENCE:direct assay:GO:0051085 chaperone cofactor-dependent protein refolding [PMID:9674429]
experiment: EXISTENCE:direct assay:GO:0051087 chaperone binding [PMID:9674429]
experiment: EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:11867765]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16135516|PMID:9674429]
experiment: EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:10931304]
experiment: EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:7984243]
experiment: EXISTENCE:mutant phenotype:GO:0043531 ADP binding [PMID:11867765]
experiment: EXISTENCE:mutant phenotype:GO:0070370 cellular heat acclimation [PMID:2188365]
experiment: EXISTENCE:mutant phenotype:GO:0070414 trehalose metabolism in response to heat stress [PMID:9797333]
note: Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responds to stresses including heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation
codon start: 1
product: chaperone ATPase HSP104
translation: MNDQTQFTERALTILTLAQKLASDHQHPQLQPIHILAAFIETPEDGSVPYLQNLIEKGRYDYDLFKKVVNRNLVRIPQQQPAPAEITPSYALGKVLQDAAKIQKQQKDSFIAQDHILFALFNDSSIQQIFKEAQVDIEAIKQQALELRGNTRIDSRGADTNTPLEYLSKYAIDMTEQARQGKLDPVIGREEEIRSTIRVLARRIKSNPCLIGEPGIGKTAIIEGVAQRIIDDDVPTILQGAKLFSLDLAALTAGAKYKGDFEERFKGVLKEIEESKTLIVLFIDEIHMLMGNGKDDAANILKPALSRGQLKVIGATTNNEYRSIVEKDGAFERRFQKIEVAEPSVRQTVAILRGLQPKYEIHHGVRILDSALVTAAQLAKRYLPYRRLPDSALDLVDISCAGVAVARDSKPEELDSKERQLQLIQVEIKALERDEDADSTTKDRLKLARQKEASLQEELEPLRQRYNEEKHGHEELTQAKKKLDELENKALDAERRYDTATAADLRYFAIPDIKKQIEKLEDQVAEEERRAGANSMIQNVVDSDTISETAARLTGIPVKKLSESENEKLIHMERDLSSEVVGQMDAIKAVSNAVRLSRSGLANPRQPASFLFLGLSGSGKTELAKKVAGFLFNDEDMMIRVDCSELSEKYAVSKLLGTTAGYVGYDEGGFLTNQLQYKPYSVLLFDEVEKAHPDVLTVMLQMLDDGRITSGQGKTIDCSNCIVIMTSNLGAEFINSQQGSKIQESTKNLVMGAVRQHFRPEFLNRISSIVIFNKLSRKAIHKIVDIRLKEIEERFEQNDKHYKLNLTQEAKDFLAKYGYSDDMGARPLNRLIQNEILNKLALRILKNEIKDKETVNVVLKKGKSRDENVPEEAEECLEVLPNHEATIGADTLGDDDNEDSMEIDDDLD
SIO_010081: YLL026W
subclass of: SO_0000673
so part of: YLL026W
location: 88623..91349
location: region:88623-91349:1
so has part: feature:88623-91349:1:exon

NP_013074.1
type: Protein
SIO_000068: ncbiprotein

S000003949
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:88623-91349:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1206; Autonomously Replicating Sequence
so part of: sequence
location: 91419..91660
location: region:91419-91660:1
so has part: feature:91419-91660:1:region

S000118469
type: SGD
SIO_000068: sgd

position:91419:1
position: 91419
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:91660:1
position: 91660
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91419-91660:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(92050..92381)
location: region:92050-92381:-1
so has part: feature:92050-92381:-1:region

S000007064
type: SGD
SIO_000068: sgd

position:92050:-1
position: 92050
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:92381:-1
position: 92381
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92050-92381:-1:region

YNCL0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0001W
so part of: sequence
location: 92548..92650
location: region:92548-92650:1
so has part: feature:92548-92650:1:exon
subclass of: SO_0000663

850634
type: Gene
SIO_000068: ncbigene

position:92548:1
position: 92548
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:92650:1
position: 92650
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92548-92650:1:exon

YNCL0001W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0001W
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin
SIO_010081: YNCL0001W
subclass of: SO_0000673
so part of: YNCL0001W
location: join(92548..92583,92615..92650)
location: region:92548-92650:1
so has part: feature:92548-92583:1:exon
so has part: feature:92615-92650:1:exon

S000006683
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92548-92583:1:exon

position:92583:1
position: 92583
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:92615-92650:1:exon

position:92615:1
position: 92615
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLL025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU17
locus tag: YLL025W
so part of: sequence
location: <94747..>95121
location: region:94747-95121:1
so has part: feature:94747-95121:1:exon
subclass of: SO_0000010

850635
type: Gene
SIO_000068: ncbigene

position:94747:1
position: 94747
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:95121:1
position: 95121
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94747-95121:1:exon

YLL025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU17
locus tag: YLL025W
product: seripauperin PAU17
transcript id: NM_001181845.1
SIO_010081: YLL025W
subclass of: SO_0000673
so part of: YLL025W
location: <94747..>95121
location: region:94747-95121:1
so has part: feature:94747-95121:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94747-95121:1:exon

YLL025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU17
locus tag: YLL025W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene
codon start: 1
product: seripauperin PAU17
translation: MVKLTSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAEYYMFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPADQVTRVITGVPWYSTRLRPAISSALSADGIYTAVPN
SIO_010081: YLL025W
subclass of: SO_0000673
so part of: YLL025W
location: 94747..95121
location: region:94747-95121:1
so has part: feature:94747-95121:1:exon

NP_013075.1
type: Protein
SIO_000068: ncbiprotein

S000003948
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94747-95121:1:exon

YLL024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YG102
gene: SSA2
locus tag: YLL024C
gene synonym: YG102
so part of: sequence
location: complement(<95566..>97485)
location: region:95566-97485:-1
so has part: feature:95566-97485:-1:exon
subclass of: SO_0000010

850636
type: Gene
SIO_000068: ncbigene

position:95566:-1
position: 95566
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97485:-1
position: 97485
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:95566-97485:-1:exon

YLL024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YG102
gene: SSA2
locus tag: YLL024C
gene synonym: YG102
product: Hsp70 family chaperone SSA2
transcript id: NM_001181844.1
SIO_010081: YLL024C
subclass of: SO_0000673
so part of: YLL024C
location: complement(<95566..>97485)
location: region:95566-97485:-1
so has part: feature:95566-97485:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:95566-97485:-1:exon

YLL024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YG102
gene: SSA2
locus tag: YLL024C
gene synonym: YG102
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:25853343]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10745074]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:10893257]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8755907]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16806052]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:16413483]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7867784]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:8755907]
experiment: EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:27178214]
experiment: EXISTENCE:genetic interaction:GO:0051082 unfolded protein binding [PMID:9789005]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9448096]
experiment: EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]
experiment: EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343|PMID:33074312]
note: HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation; targeted to vacuole via AP-3 pathway
codon start: 1
product: Hsp70 family chaperone SSA2
translation: MSKAVGIDLGTTYSCVAHFSNDRVDIIANDQGNRTTPSFVGFTDTERLIGDAAKNQAAMNPANTVFDAKRLIGRNFNDPEVQGDMKHFPFKLIDVDGKPQIQVEFKGETKNFTPEQISSMVLGKMKETAESYLGAKVNDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKGKEEHVLIFDLGGGTFDVSLLSIEDGIFEVKATAGDTHLGGEDFDNRLVNHFIQEFKRKNKKDLSTNQRALRRLRTACERAKRTLSSSAQTSVEIDSLFEGIDFYTSITRARFEELCADLFRSTLDPVEKVLRDAKLDKSQVDEIVLVGGSTRIPKVQKLVTDYFNGKEPNRSINPDEAVAYGAAVQAAILTGDESSKTQDLLLLDVAPLSLGIETAGGVMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERAKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDVDSNGILNVSAVEKGTGKSNKITITNDKGRLSKEDIEKMVAEAEKFKEEDEKESQRIASKNQLESIAYSLKNTISEAGDKLEQADKDAVTKKAEETIAWLDSNTTATKEEFDDQLKELQEVANPIMSKLYQAGGAPEGAAPGGFPGGAPPAPEAEGPTVEEVD
SIO_010081: YLL024C
subclass of: SO_0000673
so part of: YLL024C
location: complement(95566..97485)
location: region:95566-97485:-1
so has part: feature:95566-97485:-1:exon

NP_013076.1
type: Protein
SIO_000068: ncbiprotein

S000003947
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:95566-97485:-1:exon

YLL023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POM33
locus tag: YLL023C
so part of: sequence
location: complement(<97997..>98836)
location: region:97997-98836:-1
so has part: feature:97997-98836:-1:exon
subclass of: SO_0000010

850637
type: Gene
SIO_000068: ncbigene

position:97997:-1
position: 97997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:98836:-1
position: 98836
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97997-98836:-1:exon

YLL023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POM33
locus tag: YLL023C
product: nucleoporin POM33
transcript id: NM_001181843.1
SIO_010081: YLL023C
subclass of: SO_0000673
so part of: YLL023C
location: complement(<97997..>98836)
location: region:97997-98836:-1
so has part: feature:97997-98836:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:97997-98836:-1:exon

YLL023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POM33
locus tag: YLL023C
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:20498018]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20498018|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:20498018]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:20498018]
note: Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
codon start: 1
product: nucleoporin POM33
translation: MSSRPANNQGPPNLPARDKSLVQRFMAVAKSLQFAWFTGHSVVLISSILYLLKMSEFYYRSAYLGVIESFGIIIYQQFFTRNEPLQTQDAAATKASIKSRVAGLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLPKVFHLSSKDSSKILSFIDKFVVQYNDLCMHWVGTAELLIFILVLFRAILCFQRSWIILVVYAIFIKLRYENSKYMKAAFAQWRVRMDGIISHPSIPPFVKRAYNAIKMSLIRLSEYRLSGAPQVTKKQN
SIO_010081: YLL023C
subclass of: SO_0000673
so part of: YLL023C
location: complement(97997..98836)
location: region:97997-98836:-1
so has part: feature:97997-98836:-1:exon

NP_013077.1
type: Protein
SIO_000068: ncbiprotein

S000003946
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:97997-98836:-1:exon

YLL022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HIF1
locus tag: YLL022C
so part of: sequence
location: complement(<99044..>100201)
location: region:99044-100201:-1
so has part: feature:99044-100201:-1:exon
subclass of: SO_0000010

850638
type: Gene
SIO_000068: ncbigene

position:99044:-1
position: 99044
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:100201:-1
position: 100201
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99044-100201:-1:exon

YLL022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HIF1
locus tag: YLL022C
product: Hif1p
transcript id: NM_001181842.1
SIO_010081: YLL022C
subclass of: SO_0000673
so part of: YLL022C
location: complement(<99044..>100201)
location: region:99044-100201:-1
so has part: feature:99044-100201:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99044-100201:-1:exon

YLL022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HIF1
locus tag: YLL022C
experiment: EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:14761951|PMID:15099519]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14761951|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:15099519]
experiment: EXISTENCE:direct assay:GO:0016573 histone acetylation [PMID:14761951]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:15099519]
experiment: EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:14761951|PMID:15099519]
experiment: EXISTENCE:mutant phenotype:GO:0000123 histone acetyltransferase complex [PMID:14761951]
experiment: EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:14761951]
experiment: EXISTENCE:physical interaction:GO:0016573 histone acetylation [PMID:14761951]
note: Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p
codon start: 1
product: Hif1p
translation: MKLRAEDVLANGTSRHKVQIDMERQVQIAKDLLAQKKFLEAAKRCQQTLDSLPKDGLLPDPELFTIFAQAVYNMEVQNSGNLFGDALLAGDDGSGSESESEPESDVSNGEEGNENGQTEIPNSRMFQFDQEEEDLTGDVDSGDSEDSGEGSEEEEENVEKEEERLALHELANFSPANEHDDEIEDVSQLRKSGFHIYFENDLYENALDLLAQALMLLGRPTADGQSLTENSRLRIGDVYILMGDIEREAEMFSRAIHHYLKALGYYKTLKPAEQVTEKVIQAEFLVCDALRWVDQVPAKDKLKRFKHAKALLEKHMTTRPKDSELQQARLAQIQDDIDEVQENQQHGSKRPLSQPTTSIGFPALEKPLGDFNDLSQLVKKKPRRH
SIO_010081: YLL022C
subclass of: SO_0000673
so part of: YLL022C
location: complement(99044..100201)
location: region:99044-100201:-1
so has part: feature:99044-100201:-1:exon

NP_013078.1
type: Protein
SIO_000068: ncbiprotein

S000003945
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99044-100201:-1:exon

YLL021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FUS6
alternative label: PEA1
alternative label: PPF1
gene: SPA2
locus tag: YLL021W
gene synonym: FUS6; PEA1; PPF1
so part of: sequence
location: <100947..>105347
location: region:100947-105347:1
so has part: feature:100947-105347:1:exon
subclass of: SO_0000010

850639
type: Gene
SIO_000068: ncbigene

position:100947:1
position: 100947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:105347:1
position: 105347
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100947-105347:1:exon

YLL021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FUS6
alternative label: PEA1
alternative label: PPF1
gene: SPA2
locus tag: YLL021W
gene synonym: FUS6; PEA1; PPF1
product: Spa2p
transcript id: NM_001181841.1
SIO_010081: YLL021W
subclass of: SO_0000673
so part of: YLL021W
location: <100947..>105347
location: region:100947-105347:1
so has part: feature:100947-105347:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100947-105347:1:exon

YLL021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FUS6
alternative label: PEA1
alternative label: PPF1
gene: SPA2
locus tag: YLL021W
gene synonym: FUS6; PEA1; PPF1
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9214378]
experiment: EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9632790]
experiment: EXISTENCE:direct assay:GO:0005078 MAP-kinase scaffold activity [PMID:12361575]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575|PMID:2647769]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9214378]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23673619]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9214378|PMID:2647769]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:genetic interaction:GO:0031382 mating projection formation [PMID:9443897]
experiment: EXISTENCE:genetic interaction:GO:0036267 invasive filamentous growth [PMID:9443897]
experiment: EXISTENCE:genetic interaction:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:12857882]
experiment: EXISTENCE:mutant phenotype:GO:0005078 MAP-kinase scaffold activity [PMID:12361575]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:8909546]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077|PMID:9443897]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8013906|PMID:8909546]
experiment: EXISTENCE:mutant phenotype:GO:0031384 regulation of initiation of mating projection growth [PMID:14734532]
experiment: EXISTENCE:mutant phenotype:GO:0031385 regulation of termination of mating projection growth [PMID:14734532]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10085294|PMID:11740491|PMID:12857882|PMID:8909546|PM ID:9571251|PMID:9632790|PMID:16166638]
experiment: EXISTENCE:mutant phenotype:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:12857882|PMID:19633059]
note: Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication
codon start: 1
product: Spa2p
translation: MGTSSEVSLAHHRDIFHYYVSLKTFFEVTGENRDRSNSTRAQKARAKLLKLSSSQFYELSTDVSDELQRRIGEDANQPDYLLPKANFHMKRNQARQKLANLSQTRFNDLLDDILFEIKRRGFDKDLDAPRPPLPQPMKQEVSKDSDDTARTSTNSSSVTQVAPNVSVQPSLVIPKMASIDWSSEEEEEEQVKEKPNEPEGKQTSMDEKKEAKPALNPIVTDSDLPDSQVLARDITSMARTPTTTHKNYWDVNDSPIIKVDKDIDNEKGPEQLKSPEVQRAENNNPNSEMEDKVKELTDLNSDLHLQIEDLNAKLASLTSEKEKEKKEEKEEKEKEKNLKINYTIDESFQKELLSLNSQIGELSIENENLKQKISEFELHQKKNDNHNDLKITDGFISKYSSADGLIPAQYILNANNLIIQFTTRLSAVPIGDSTAISHQIGEELFQILSQLSNLISQLLLSADLLQYKDQVILLKASLSHAITSIRYFSVYGPVLIPKITVQAAVSEVCFAMCNLIDSAKIKSDSNGESTTSNEGNRQVLEYSSPTATTPMTPTFPSTSGINMKKGFINPRKPASFLNDVEEEESPVKPLKITQKAINSPIIRPSSSNGVPTTSRKPSGTGLFSLMIDSSIAKNSSHKEDNDKYVSPIKAVTSASNSASSNISEIPKLTLPPQAKIGTVIPPSENQVPNIKIENTEEDNKRSDITNEISVKPTSSIADKLKQFEQSSEKKSSPKENPIAKEEMDSKPKLSNKFITSMNDVSTDDSSSDGNENDDADDDDDFTYMALKQTMKREGSKIEKNNDSKLPANIVELDLHESPESVKIESPESIKEITSSEMSSEMPSSSLPKRLVEDVEPSEMPEKGASVESVRKKNFQEPLGNVESPDMTQKVKSLGMTGKAVGPESDSRVESPGMTGQIKSLNMAGKVVGPEADSRVESPGMKEQIKSLGMTGKITAQESIKSPEAARKLASSGEVDKIESPRMVRESESLEAVGNTIPSNMTVKMESPNLKGNTVSEPQEIRRDIASSEPIENVDPPKVLKKIVFPKAVNRTGSPKSVEKTPSSATLKKSGLPEPNSQIVSPELAKNSPLAPIKKNVELRETNKPHTETITSVEPTNKDANTSWRDADLNRTIKREEEDEDFDRVNHNIQITGAYTKTGKIDYHKIPVDRKAKSEAEVHTSEEDIDESNNVNGKRADAQIHITERKHAFVNPTENSQVKKTSHSPFLNSKPVQYENSESNGGINNHIKIKNTGETTAHDEKHYSDDDDSSYQFVPMKHEEQEQEQNRSEEEESEDDDEEEEDSDFDVDTFDIENPDNTLSELLLYLEHQTMDVISTIQSLLTSIKKPQVTKGNLRGESNAINQVIGQMVDATSISMEQSRNANLKKHGDWVVQSLRDCSRRMTILCQLTGDGILAKEKSDQDYADKNFKQRLAGIAFDVAKCTKELVKTVEEASLKDEINYLNSKLK
SIO_010081: YLL021W
subclass of: SO_0000673
so part of: YLL021W
location: 100947..105347
location: region:100947-105347:1
so has part: feature:100947-105347:1:exon

NP_013079.1
type: Protein
SIO_000068: ncbiprotein

S000003944
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100947-105347:1:exon

YLL019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KNS1
locus tag: YLL019C
so part of: sequence
location: complement(<105686..>107899)
location: region:105686-107899:-1
so has part: feature:105686-107899:-1:exon
subclass of: SO_0000010

850641
type: Gene
SIO_000068: ncbigene

position:105686:-1
position: 105686
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:107899:-1
position: 107899
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105686-107899:-1:exon

YLL019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KNS1
locus tag: YLL019C
product: serine/threonine protein kinase KNS1
transcript id: NM_001181839.1
SIO_010081: YLL019C
subclass of: SO_0000673
so part of: YLL019C
location: complement(<105686..>107899)
location: region:105686-107899:-1
so has part: feature:105686-107899:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:105686-107899:-1:exon

YLL019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KNS1
locus tag: YLL019C
EC number: 2.7.12.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:25631054|PMID:8910305]
experiment: EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:8910305]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22364741]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22364741]
experiment: EXISTENCE:direct assay:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]
experiment: EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:8910305]
experiment: EXISTENCE:mutant phenotype:GO:0004713 protein tyrosine kinase activity [PMID:8910305]
experiment: EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]
note: Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
codon start: 1
product: serine/threonine protein kinase KNS1
translation: MSQNIQIGTRKRSRANMNNSTTTGPANNTSSNKTFLDNFEETRTNKLLDEMFARQNSFLTDNLRNSLDLNQADNPLRPRQHQHQLFLDNENAIELDEEPRIINTTINNSNNHNSSRVDEDADDDIIFIKEQPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAATSNSTYITTPKKFKKQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVTQTENELLHLTGSCAKTLEGNKAVNLTIAHSTSPFSNPPAQIASLPQSNLKKQIGSSLRKFTSNGSSESASSNKSNFKTDKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHENLEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTITTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFNLGILDDGIATYNNTQG
SIO_010081: YLL019C
subclass of: SO_0000673
so part of: YLL019C
location: complement(105686..107899)
location: region:105686-107899:-1
so has part: feature:105686-107899:-1:exon

NP_013081.1
type: Protein
SIO_000068: ncbiprotein

S000003942
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:105686-107899:-1:exon

YLL018C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX19
locus tag: YLL018C-A
so part of: sequence
location: complement(<108676..>108972)
location: region:108676-108972:-1
so has part: feature:108676-108972:-1:exon
subclass of: SO_0000010

850642
type: Gene
SIO_000068: ncbigene

position:108676:-1
position: 108676
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108972:-1
position: 108972
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108676-108972:-1:exon

YLL018C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX19
locus tag: YLL018C-A
product: Cox19p
transcript id: NM_001184338.1
SIO_010081: YLL018C-A
subclass of: SO_0000673
so part of: YLL018C-A
location: complement(<108676..>108972)
location: region:108676-108972:-1
so has part: feature:108676-108972:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108676-108972:-1:exon

YLL018C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX19
locus tag: YLL018C-A
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:17237235]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12171940]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12171940]
experiment: EXISTENCE:direct assay:GO:0030001 metal ion transport [PMID:12171940]
experiment: EXISTENCE:direct assay:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:12171940]
note: Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
codon start: 1
product: Cox19p
translation: MSGNPGSSLSALRPTPPERGSFPLDHDGECTKYMQEYLKCMQLVQNENAMNCRLLAKDYLRCRMDHQLMDYDEWSHLGLPEDAPGNNGKTIKDATDNK
SIO_010081: YLL018C-A
subclass of: SO_0000673
so part of: YLL018C-A
location: complement(108676..108972)
location: region:108676-108972:-1
so has part: feature:108676-108972:-1:exon

NP_013082.1
type: Protein
SIO_000068: ncbiprotein

S000007245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108676-108972:-1:exon

YLL018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPS1
locus tag: YLL018C
so part of: sequence
location: complement(<109902..>111575)
location: region:109902-111575:-1
so has part: feature:109902-111575:-1:exon
subclass of: SO_0000010

850643
type: Gene
SIO_000068: ncbigene

position:109902:-1
position: 109902
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:111575:-1
position: 111575
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:109902-111575:-1:exon

YLL018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPS1
locus tag: YLL018C
product: aspartate--tRNA ligase DPS1
transcript id: NM_001181838.1
SIO_010081: YLL018C
subclass of: SO_0000673
so part of: YLL018C
location: complement(<109902..>111575)
location: region:109902-111575:-1
so has part: feature:109902-111575:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:109902-111575:-1:exon

YLL018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPS1
locus tag: YLL018C
EC number: 6.1.1.12
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12888345]
experiment: EXISTENCE:direct assay:GO:0004815 aspartate-tRNA ligase activity [PMID:8263943]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16113655]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16113655]
experiment: EXISTENCE:direct assay:GO:0006422 aspartyl-tRNA aminoacylation [PMID:8263943]
note: Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL)
codon start: 1
product: aspartate--tRNA ligase DPS1
translation: MSQDENIVKAVEESAEPAQVILGEDGKPLSKKALKKLQKEQEKQRKKEERALQLEAEREAREKKAAAEDTAKDNYGKLPLIQSRDSDRTGQKRVKFVDLDEAKDSDKEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSELPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIEMLRAAGKEIGDFEDLSTENEKFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFPRDPKRLRP
SIO_010081: YLL018C
subclass of: SO_0000673
so part of: YLL018C
location: complement(109902..111575)
location: region:109902-111575:-1
so has part: feature:109902-111575:-1:exon

NP_013083.1
type: Protein
SIO_000068: ncbiprotein

S000003941
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:109902-111575:-1:exon

YLL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SDC25
locus tag: YLL017W
gene synonym: SDC25
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:2188363]
experiment: EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:1986220]
note: Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
pseudo: true
so part of: sequence
location: 112234..112545
location: region:112234-112545:1
so has part: feature:112234-112545:1:exon

2827706
type: Gene
SIO_000068: ncbigene

S000003940
type: SGD
SIO_000068: sgd

position:112234:1
position: 112234
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:112545:1
position: 112545
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112234-112545:1:exon

YLL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SDC25
locus tag: YLL017W
gene synonym: SDC25
pseudo: true
SIO_010081: YLL017W
subclass of: SO_0000673
so part of: YLL017W
location: 112234..112545
location: region:112234-112545:1
so has part: feature:112234-112545:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:112234-112545:1:exon

YLL016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDC25
locus tag: YLL016W
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:2188363]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:10747953]
experiment: EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:1986220]
note: Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
pseudo: true
so part of: sequence
location: 112847..115993
location: region:112847-115993:1
so has part: feature:112847-115993:1:exon

850644
type: Gene
SIO_000068: ncbigene

S000003939
type: SGD
SIO_000068: sgd

position:112847:1
position: 112847
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:115993:1
position: 115993
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112847-115993:1:exon

YLL016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDC25
locus tag: YLL016W
pseudo: true
SIO_010081: YLL016W
subclass of: SO_0000673
so part of: YLL016W
location: 112847..115993
location: region:112847-115993:1
so has part: feature:112847-115993:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:112847-115993:1:exon

YLL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BPT1
locus tag: YLL015W
so part of: sequence
location: <116432..>121111
location: region:116432-121111:1
so has part: feature:116432-121111:1:exon
subclass of: SO_0000010

850645
type: Gene
SIO_000068: ncbigene

position:116432:1
position: 116432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121111:1
position: 121111
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116432-121111:1:exon

YLL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BPT1
locus tag: YLL015W
product: ATP-binding cassette bilirubin transporter BPT1
transcript id: NM_001181835.1
SIO_010081: YLL015W
subclass of: SO_0000673
so part of: YLL015W
location: <116432..>121111
location: region:116432-121111:1
so has part: feature:116432-121111:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116432-121111:1:exon

YLL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BPT1
locus tag: YLL015W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12455987|PMID:23658021]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0015086 cadmium ion transmembrane transporter activity [PMID:12455987]
experiment: EXISTENCE:direct assay:GO:0015691 cadmium ion transport [PMID:12455987]
experiment: EXISTENCE:genetic interaction:GO:0015127 bilirubin transmembrane transporter activity [PMID:10790694]
experiment: EXISTENCE:genetic interaction:GO:0015723 bilirubin transport [PMID:10790694]
experiment: EXISTENCE:mutant phenotype:GO:0015127 bilirubin transmembrane transporter activity [PMID:10790694]
experiment: EXISTENCE:mutant phenotype:GO:0015723 bilirubin transport [PMID:10790694]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:23658021]
note: ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
codon start: 1
product: ATP-binding cassette bilirubin transporter BPT1
translation: MSSLEVVDGCPYGYRPYPDSGTNALNPCFISVISAWQAVFFLLIGSYQLWKLYKNNKVPPRFKNFPTLPSKINSRHLTHLTNVCFQSTLIICELALVSQSSDRVYPFILKKALYLNLLFNLGISLPTQYLAYFKSTFSMGNQLFYYMFQILLQLFLILQRYYHGSSNERLTVISGQTAMILEVLLLFNSVAIFIYDLCIFEPINELSEYYKKNGWYPPVHVLSYITFIWMNKLIVETYRNKKIKDPNQLPLPPVDLNIKSISKEFKANWELEKWLNRNSLWRAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLFSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACGVLGVVLFFLFMILTRVFDLAENFWLKYWSESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEKGGYLK
SIO_010081: YLL015W
subclass of: SO_0000673
so part of: YLL015W
location: 116432..121111
location: region:116432-121111:1
so has part: feature:116432-121111:1:exon

NP_013086.1
type: Protein
SIO_000068: ncbiprotein

S000003938
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116432-121111:1:exon

YLL014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMC6
locus tag: YLL014W
so part of: sequence
location: <121322..>121648
location: region:121322-121648:1
so has part: feature:121322-121648:1:exon
subclass of: SO_0000010

850646
type: Gene
SIO_000068: ncbigene

position:121322:1
position: 121322
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121648:1
position: 121648
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:121322-121648:1:exon

YLL014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMC6
locus tag: YLL014W
product: Emc6p
transcript id: NM_001181834.1
SIO_010081: YLL014W
subclass of: SO_0000673
so part of: YLL014W
location: <121322..>121648
location: region:121322-121648:1
so has part: feature:121322-121648:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:121322-121648:1:exon

YLL014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMC6
locus tag: YLL014W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]
experiment: EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]
note: Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
codon start: 1
product: Emc6p
translation: MSSNEEVFTQINATANVVDNKKRLLFVQDSSALVLGLVAGFLQIESVHGFIWFLILYNLINVIYIVWICQLQPGKFYQSPLHDIFFESFFREITGFVMAWTFGYALIG
SIO_010081: YLL014W
subclass of: SO_0000673
so part of: YLL014W
location: 121322..121648
location: region:121322-121648:1
so has part: feature:121322-121648:1:exon

NP_013087.1
type: Protein
SIO_000068: ncbiprotein

S000003937
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:121322-121648:1:exon

YLL013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUF3
locus tag: YLL013C
so part of: sequence
location: complement(<122075..>124714)
location: region:122075-124714:-1
so has part: feature:122075-124714:-1:exon
subclass of: SO_0000010

850647
type: Gene
SIO_000068: ncbigene

position:122075:-1
position: 122075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:124714:-1
position: 124714
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122075-124714:-1:exon

YLL013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUF3
locus tag: YLL013C
product: mRNA-binding protein PUF3
transcript id: NM_001181833.1
SIO_010081: YLL013C
subclass of: SO_0000673
so part of: YLL013C
location: complement(<122075..>124714)
location: region:122075-124714:-1
so has part: feature:122075-124714:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122075-124714:-1:exon

YLL013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUF3
locus tag: YLL013C
experiment: EXISTENCE:direct assay:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:16317069]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11101532|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12730603]
experiment: EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:17210948]
experiment: EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:17210948]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:18523582]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:17210948]
experiment: EXISTENCE:mutant phenotype:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:29248374]
experiment: EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:26051939]
experiment: EXISTENCE:mutant phenotype:GO:0051646 mitochondrion localization [PMID:17210948]
note: Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochondria during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; translationally represses oxidative stress-linked genes; regulates CoQ biosynthesis
codon start: 1
product: mRNA-binding protein PUF3
translation: MEMNMDMDMDMELASIVSSLSALSHSNNNGGQAAAAGIVNGGAAGSQQIGGFRRSSFTTANEVDSEILLLHGSSESSPIFKKTALSVGTAPPFSTNSKKFFGNGGNYYQYRSTDTASLSSASYNNYHTHHTAANLGKNNKVNHLLGQYSASIAGPVYYNGNDNNNSGGEGFFEKFGKSLIDGTRELESQDRPDAVNTQSQFISKSVSNASLDTQNTFEQNVESDKNFNKLNRNTTNSGSLYHSSSNSGSSASLESENAHYPKRNIWNVANTPVFRPSNNPAAVGATNVALPNQQDGPANNNFPPYMNGFPPNQFHQGPHYQNFPNYLIGSPSNFISQMISVQIPANEDTEDSNGKKKKKANRPSSVSSPSSPPNNSPFPFAYPNPMMFMPPPPLSAPQQQQQQQQQQQQEDQQQQQQQENPYIYYPTPNPIPVKMPKDEKTFKKRNNKNHPANNSNNANKQANPYLENSIPTKNTSKKNASSKSNESTANNHKSHSHSHPHSQSLQQQQQTYHRSPLLEQLRNSSSDKNSNSNMSLKDIFGHSLEFCKDQHGSRFIQRELATSPASEKEVIFNEIRDDAIELSNDVFGNYVIQKFFEFGSKIQKNTLVDQFKGNMKQLSLQMYACRVIQKALEYIDSNQRIELVLELSDSVLQMIKDQNGNHVIQKAIETIPIEKLPFILSSLTGHIYHLSTHSYGCRVIQRLLEFGSSEDQESILNELKDFIPYLIQDQYGNYVIQYVLQQDQFTNKEMVDIKQEIIETVANNVVEYSKHKFASNVVEKSILYGSKNQKDLIISKILPRDKNHALNLEDDSPMILMIKDQFANYVIQKLVNVSEGEGKKLIVIAIRAYLDKLNKSNSLGNRHLASVEKLAALVENAEV
SIO_010081: YLL013C
subclass of: SO_0000673
so part of: YLL013C
location: complement(122075..124714)
location: region:122075-124714:-1
so has part: feature:122075-124714:-1:exon

NP_013088.1
type: Protein
SIO_000068: ncbiprotein

S000003936
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122075-124714:-1:exon

YLL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YEH1
locus tag: YLL012W
so part of: sequence
location: <125534..>127255
location: region:125534-127255:1
so has part: feature:125534-127255:1:exon
subclass of: SO_0000010

850648
type: Gene
SIO_000068: ncbigene

position:125534:1
position: 125534
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:127255:1
position: 127255
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:125534-127255:1:exon

YLL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YEH1
locus tag: YLL012W
product: sterol esterase
transcript id: NM_001181832.1
SIO_010081: YLL012W
subclass of: SO_0000673
so part of: YLL012W
location: <125534..>127255
location: region:125534-127255:1
so has part: feature:125534-127255:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:125534-127255:1:exon

YLL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YEH1
locus tag: YLL012W
EC number: 3.1.1.13
experiment: EXISTENCE:direct assay:GO:0004771 sterol esterase activity [PMID:15713625]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:15713625|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]
experiment: EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15713625]
note: Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication
codon start: 1
product: sterol esterase
translation: MGVSAVLKRARNLLATFIVCCFMAVVLVLALAHHFINEHRDTRSSSTQIEVDDESKRNVHHDHVLTRTNAYATPYLDLEHDKKNGIVYDHTRTVVRKKNHEVGSSSLHKNLFHKFLTKLIFRFIEKEKVTEGVTQGKFNNSSNEIANHEPVFEKIPVQCDNPLQNLILSEDLTLVADLNYYFNQYNIQIEEFRLETEDGFVIDLWHLIPKYRTTDSDKKKRPPILMLHGLLQSSGSFASNGRKSLAYFLYQSGYDIWLGNNRCGFRPEWNEAKVPTLASRWDWDLREMVKYDLTLLIDTVLAKTQFEKLTLISHSQGTTQGFMGLVNEDKFFPPGSGSKESFFTSKIANYIALAPAVYPGPLLNEKLFVKLMTKEIENPWFFGETSFFEIMMIVRNLCVGESLFSFVCYTIFNYLFDWNDTLWDTALRDRHFLFSPVHVSVKLMQWWLSPDPNKVSFKFGSHKMFPDNVKWFSDASKAPNIYLFVPKQDRLVDGERLINHFVNVESNVNYKIWYIDEYAHIDVLWAHDVIERIGKPILQNLNNYYSKKPSSAFESDCSDTEVETELEMVAEKA
SIO_010081: YLL012W
subclass of: SO_0000673
so part of: YLL012W
location: 125534..127255
location: region:125534-127255:1
so has part: feature:125534-127255:1:exon

NP_013089.1
type: Protein
SIO_000068: ncbiprotein

S000003935
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:125534-127255:1:exon

YLL011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOF1
locus tag: YLL011W
so part of: sequence
location: <127523..>128992
location: region:127523-128992:1
so has part: feature:127523-128992:1:exon
subclass of: SO_0000010

850649
type: Gene
SIO_000068: ncbigene

position:127523:1
position: 127523
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:128992:1
position: 128992
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:127523-128992:1:exon

YLL011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOF1
locus tag: YLL011W
product: rRNA-processing protein SOF1
transcript id: NM_001181831.1
SIO_010081: YLL011W
subclass of: SO_0000673
so part of: YLL011W
location: <127523..>128992
location: region:127523-128992:1
so has part: feature:127523-128992:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:127523-128992:1:exon

YLL011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOF1
locus tag: YLL011W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15367670|PMID:8508778]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8508778]
note: Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene
codon start: 1
product: rRNA-processing protein SOF1
translation: MKIKTIKRSADDYVPVKSTQESQMPRNLNPELHPFERAREYTKALNATKLERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIKRREANERRTRKDMPYISERKKQIVGTVHKYEDSGRDRKRRKEDDKRDTQEK
SIO_010081: YLL011W
subclass of: SO_0000673
so part of: YLL011W
location: 127523..128992
location: region:127523-128992:1
so has part: feature:127523-128992:1:exon

NP_013090.1
type: Protein
SIO_000068: ncbiprotein

S000003934
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:127523-128992:1:exon

YLL010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSR1
locus tag: YLL010C
so part of: sequence
location: complement(<129330..>130613)
location: region:129330-130613:-1
so has part: feature:129330-130613:-1:exon
subclass of: SO_0000010

850650
type: Gene
SIO_000068: ncbigene

position:129330:-1
position: 129330
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130613:-1
position: 130613
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129330-130613:-1:exon

YLL010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSR1
locus tag: YLL010C
product: phosphatase
transcript id: NM_001181830.1
SIO_010081: YLL010C
subclass of: SO_0000673
so part of: YLL010C
location: complement(<129330..>130613)
location: region:129330-130613:-1
so has part: feature:129330-130613:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129330-130613:-1:exon

YLL010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSR1
locus tag: YLL010C
experiment: EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:10777497]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10777497]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12090248]
experiment: EXISTENCE:genetic interaction:GO:0071472 cellular response to salt stress [PMID:10777497]
experiment: EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]
note: Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases
codon start: 1
product: phosphatase
translation: MGFISSILCCSSETTQSNSNSAYRQQQSSSLNKNRSVKHSNTKSRTRGVHQTNSPPSKTNSAATFSSTERSTGKSGISTNDNEKKKPSSPTAAVTATTTNNMTKVEKRISKDDLYEEKYEVDEDEEIDDEDNRRSRGIVQEKGDAVKDTSRQKKQQQQQQQQSQPQPQPQSQSQSQSQSQSQQRGPTVQVSSDHLIQDMNLSRVSSSSQASETSNDADDEDDEDEEYIDLTLLQQGQYHAPGYNTLLPPQDESTKGKKCLILDLDETLVHSSFKYLRSADFVLSVEIDDQVHNVYVIKRPGVEEFLERVGKLFEVVVFTASVSRYGDPLLDILDTDKVIHHRLFREACYNYEGNYIKNLSQIGRPLSDIIILDNSPASYIFHPQHAIPISSWFSDTHDNELLDIIPLLEDLSVKTSLDVGKILDVTI
SIO_010081: YLL010C
subclass of: SO_0000673
so part of: YLL010C
location: complement(129330..130613)
location: region:129330-130613:-1
so has part: feature:129330-130613:-1:exon

NP_013091.1
type: Protein
SIO_000068: ncbiprotein

S000003933
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129330-130613:-1:exon

YLL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX17
locus tag: YLL009C
so part of: sequence
location: complement(<131205..>131414)
location: region:131205-131414:-1
so has part: feature:131205-131414:-1:exon
subclass of: SO_0000010

850651
type: Gene
SIO_000068: ncbigene

position:131205:-1
position: 131205
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131414:-1
position: 131414
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131205-131414:-1:exon

YLL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX17
locus tag: YLL009C
product: copper metallochaperone COX17
transcript id: NM_001181829.1
SIO_010081: YLL009C
subclass of: SO_0000673
so part of: YLL009C
location: complement(<131205..>131414)
location: region:131205-131414:-1
so has part: feature:131205-131414:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:131205-131414:-1:exon

YLL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX17
locus tag: YLL009C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:9407107]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9407107]
experiment: EXISTENCE:direct assay:GO:0015680 protein maturation by copper ion transfer [PMID:15199057]
experiment: EXISTENCE:direct assay:GO:0016531 copper chaperone activity [PMID:15199057]
experiment: EXISTENCE:direct assay:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:15199057]
experiment: EXISTENCE:mutant phenotype:GO:0016531 copper chaperone activity [PMID:9585572]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:8662933]
note: Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant
codon start: 1
product: copper metallochaperone COX17
translation: MTETDKKQEQENHAECEDKPKPCCVCKPEKEERDTCILFNGQDSEKCKEFIEKYKECMKGYGFEVPSAN
SIO_010081: YLL009C
subclass of: SO_0000673
so part of: YLL009C
location: complement(131205..131414)
location: region:131205-131414:-1
so has part: feature:131205-131414:-1:exon

NP_013092.1
type: Protein
SIO_000068: ncbiprotein

S000003932
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131205-131414:-1:exon

YLL008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DRS1
locus tag: YLL008W
so part of: sequence
location: <131729..>133987
location: region:131729-133987:1
so has part: feature:131729-133987:1:exon
subclass of: SO_0000010

850652
type: Gene
SIO_000068: ncbigene

position:131729:1
position: 131729
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:133987:1
position: 133987
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131729-133987:1:exon

YLL008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DRS1
locus tag: YLL008W
product: putative ATP-dependent RNA helicase
transcript id: NM_001181828.1
SIO_010081: YLL008W
subclass of: SO_0000673
so part of: YLL008W
location: <131729..>133987
location: region:131729-133987:1
so has part: feature:131729-133987:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:131729-133987:1:exon

YLL008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DRS1
locus tag: YLL008W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:1454790]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:1454790]
note: Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
codon start: 1
product: putative ATP-dependent RNA helicase
translation: MVVGTKKYSNLDFVPTISDSEDDVPILDSSDDEKVEAKKTTKKRKGKNNKKKVSEGDNLDEDVHEDLDAGFKFDLDADDTTSNFQGWNFLAEGESNKDDAEAFVKKDVDLDKIIRRKGGLVKMAHIDSKQEEETEKEKVEKENDSDDEELAMDGFGMGAPMNNGDENQSEEEEEEEEKEEEEEEEEEQEEMTLEKGGKDDEIDEEDDSEEAKADFYAPETEGDEAKKQMYENFNSLSLSRPVLKGLASLGYVKPSPIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPAKIASTRVIVLLPTRELAIQVADVGKQIARFVSGITFGLAVGGLNLRQQEQMLKSRPDIVIATPGRFIDHIRNSASFNVDSVEILVMDEADRMLEEGFQDELNEIMGLLPSNRQNLLFSATMNSKIKSLVSLSLKKPVRIMIDPPKKAATKLTQEFVRIRKRDHLKPALLFNLIRKLDPTGQKRIVVFVARKETAHRLRIIMGLLGMSVGELHGSLTQEQRLDSVNKFKNLEVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGRSVTFVGESSQDRSIVRAAIKSVEENKSLTQGKALGRNVDWVQIEETNKLVESMNDTIEDILVEEKEEKEILRAEMQLRKGENMLKHKKEIQARPRRTWFQSESDKKNSKVLGALSRNKKVTNSKKRKREEAKADGNGARSYRKTKTDRIADQERTFKKQKSTNSNKKKGFKSRR
SIO_010081: YLL008W
subclass of: SO_0000673
so part of: YLL008W
location: 131729..133987
location: region:131729-133987:1
so has part: feature:131729-133987:1:exon

NP_013093.1
type: Protein
SIO_000068: ncbiprotein

S000003931
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131729-133987:1:exon

YLL007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LMO1
locus tag: YLL007C
so part of: sequence
location: complement(<134302..>136299)
location: region:134302-136299:-1
so has part: feature:134302-136299:-1:exon
subclass of: SO_0000010

850653
type: Gene
SIO_000068: ncbigene

position:134302:-1
position: 134302
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:136299:-1
position: 136299
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:134302-136299:-1:exon

YLL007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LMO1
locus tag: YLL007C
product: Lmo1p
transcript id: NM_001181827.1
SIO_010081: YLL007C
subclass of: SO_0000673
so part of: YLL007C
location: complement(<134302..>136299)
location: region:134302-136299:-1
so has part: feature:134302-136299:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:134302-136299:-1:exon

YLL007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LMO1
locus tag: YLL007C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25598154]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25598154]
experiment: EXISTENCE:genetic interaction:GO:0035556 intracellular signal transduction [PMID:25598154]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:25598154]
experiment: EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:25598154]
note: Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein
codon start: 1
product: Lmo1p
translation: MKHNRQMPDESLENIKVLLNPKLGKPVKSLTSAQSKACYHTLISNKNLNKTSDEYEKLLANYILLCDEKYLCKTVIPDSRFWAILCDNCQKLRSETLVANLIRIFNVALKCQDSNKNEVIVSICHISRENSQLIGILLQLLSQRPIHIPLFTDTILCITLFLKCSLTLCETSLSHAVEFVPRILILLFQYNFPASMSELLYIEDLQPLILEEFVPLKQRLINFLSSVSIDDYSCSLKADLLTAIKDNSVFQKGLEMEMGDLPSINLLNAYDTFTFLNSPNGSFKRLYTEQLLFGENDFPLYEAIFKLSDQFRRLFNLSGKKENQYSDSERDLKLQIATAVLNRQTCFYKTLELFLRFWIESLAKSQSDLVSLLNLAIITLKYVCLSSSDLEAAIQTKSLLKTQVVALDSMRYKFARTLQLDSIKKEQYRTWSSSIASFDTMLSGQVRDYVRHQRLLQLQKGTWVYAENPLNPEAGTPKVYFLIVSDNHANLLAREFETQTNDLPYLFDNKILTSPGSEALANGRTKVVVLKHITSFKSIELTTPSRRTSSNVYIKLDEANVYTGVELKDRNDRTVLKFYLDTEEGRYIWLDGLKLISPFQHEDISEDTKEQIDTLFDLRKNVQMINLNVRQDIIVPPPEPSDEDEDEEFYNLETLKKVTQNFYFD
SIO_010081: YLL007C
subclass of: SO_0000673
so part of: YLL007C
location: complement(134302..136299)
location: region:134302-136299:-1
so has part: feature:134302-136299:-1:exon

NP_013094.1
type: Protein
SIO_000068: ncbiprotein

S000003930
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:134302-136299:-1:exon

YLL006W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLL006W-A
so part of: sequence
location: <136345..>136521
location: region:136345-136521:1
so has part: feature:136345-136521:1:exon
subclass of: SO_0000010

1466403
type: Gene
SIO_000068: ncbigene

position:136345:1
position: 136345
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:136521:1
position: 136521
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136345-136521:1:exon

YLL006W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLL006W-A
product: uncharacterized protein
transcript id: NM_001184559.1
SIO_010081: YLL006W-A
subclass of: SO_0000673
so part of: YLL006W-A
location: <136345..>136521
location: region:136345-136521:1
so has part: feature:136345-136521:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:136345-136521:1:exon

YLL006W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLL006W-A
note: hypothetical protein; identified by fungal homology and RT-PCR
codon start: 1
product: uncharacterized protein
translation: MTQLSQSNVERVALVYISVYFFSCISLIVYFFTFCLSVSIPKNRQHPIKIIYNNKCPS
SIO_010081: YLL006W-A
subclass of: SO_0000673
so part of: YLL006W-A
location: 136345..136521
location: region:136345-136521:1
so has part: feature:136345-136521:1:exon

NP_878116.1
type: Protein
SIO_000068: ncbiprotein

S000028560
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136345-136521:1:exon

YLL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YME6
gene: MMM1
locus tag: YLL006W
gene synonym: YME6
so part of: sequence
location: <136586..>137866
location: region:136586-137866:1
so has part: feature:136586-137866:1:exon
subclass of: SO_0000010

850654
type: Gene
SIO_000068: ncbigene

position:136586:1
position: 136586
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:137866:1
position: 137866
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136586-137866:1:exon

YLL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YME6
gene: MMM1
locus tag: YLL006W
gene synonym: YME6
product: ERMES complex subunit MMM1
transcript id: NM_001181826.1
SIO_010081: YLL006W
subclass of: SO_0000673
so part of: YLL006W
location: <136586..>137866
location: region:136586-137866:1
so has part: feature:136586-137866:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:136586-137866:1:exon

YLL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YME6
gene: MMM1
locus tag: YLL006W
gene synonym: YME6
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11266455|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:19556461]
experiment: EXISTENCE:direct assay:GO:0032865 ERMES complex [PMID:19556461|PMID:17410204]
experiment: EXISTENCE:direct assay:GO:0120013 lipid transfer activity [PMID:29279306]
experiment: EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:11266455]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:8089172]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:19556461]
experiment: EXISTENCE:mutant phenotype:GO:0015917 aminophospholipid transport [PMID:27469264]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:17410204]
experiment: EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:17410204]
experiment: EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]
experiment: EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:13679517]
note: ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose
codon start: 1
product: ERMES complex subunit MMM1
translation: MTDSENESTETDSLMTFDDYISKELPEHLQRLIMENLKGSTTNDLKQTSNNSEFNVSKNGSFKGLDDAIQALQMQSVLHPSSLGSLATSSKFSGWSFAQGFFVGQLSIVLLFIFFLKFFIFSDEPSKSKNPKPAASRHRSKFKEYPFISREFLTSLVRKGAKQHYELNEEAENEHLQELALILEKTYYNVDVHPAESLDWFNVLVAQIIQQFRSEAWHRDNILHSLNDFIGRKSPDLPEYLDTIKITELDTGDDFPIFSNCRIQYSPNSGNKKLEAKIDIDLNDHLTLGVETKLLLNYPKPGIAALPINLVVSIVRFQACLTVSLTNAEEFASTSNGSSSENGMEGNSGYFLMFSFSPEYRMEFEIKSLIGSRSKLENIPKIGSVIEYQIKKWFVERCVEPRFQFVRLPSMWPRSKNTREEKPTEL
SIO_010081: YLL006W
subclass of: SO_0000673
so part of: YLL006W
location: 136586..137866
location: region:136586-137866:1
so has part: feature:136586-137866:1:exon

NP_013095.1
type: Protein
SIO_000068: ncbiprotein

S000003929
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136586-137866:1:exon

YLL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO75
locus tag: YLL005C
so part of: sequence
location: complement(<137940..>140546)
location: region:137940-140546:-1
so has part: feature:137940-140546:-1:exon
subclass of: SO_0000010

850655
type: Gene
SIO_000068: ncbigene

position:137940:-1
position: 137940
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:140546:-1
position: 140546
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137940-140546:-1:exon

YLL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO75
locus tag: YLL005C
product: Spo75p
transcript id: NM_001181825.1
SIO_010081: YLL005C
subclass of: SO_0000673
so part of: YLL005C
location: complement(<137940..>140546)
location: region:137940-140546:-1
so has part: feature:137940-140546:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:137940-140546:-1:exon

YLL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO75
locus tag: YLL005C
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]
note: Meiosis-specific hypothetical protein; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
codon start: 1
product: Spo75p
translation: MNATKELTFNLLNKFQDKERFGSAQRHAGISLKGFISGILFSFLYFLFQLSLFIILRSRFKTIYQANVVLKIHPGSKVCFAKKKIKNYWSLFAFLKQLPGRMLDPMEKFERNERYGLDNYLFLRFLKLLIFFFAVLSIINIPILIPIHYFSRDILKENEGERYEQSFRTTSKLDKWTMSNLSPNSSNTLICHLFLSIFVVLWFHFILSSELRFVNRLGYSVLTKSKYQNILYLEGFSSKLVTQSISLETFFQPLHSDCFGVTHFIPKNLKKVHKLEIKLNKLQKSKEQIIFEIILEKYFRRVSIHRHLIANHKRFFFSKLKNHLLFQYKKLVFLTQFRISYYCTKIRLRWKKSSIFPLYYPKLYVNTETILERKYRILDKIIRKEKLIKFQVNSLKATSETKQALPDDLSSGTDIYMDKMFITFKSTLLSNVIGELLSYRLPTQNLKVIIGPNVNDIIWRNILDSSPLWKSAKYFSANILRIFVIIGWILPVAFLGLISQIPNISSLIPFTKIIHFQSPFIREVAKNLIPIVTLIIIIEIVPYFFRWLSYLRGLKTGAQIEADVQNWYFVFVFIHLFVVVTISSGFSIIIERLLNNPVSIPALLANDLPKCANFFCSFVLIRGMAYAGGNLLRIKELLFELFYYKWKRSTPHAQFKRLKTSLFFQLGSIYPIFSVLGCIGIIYSVVAPIILLLCCISFSMVFFSFSYLFKYQYNKENYSETFGKLYIQALMQLYAGIYFMEFCLLGLFTLFDQYTLSTIMLVVFALTVITHSKISKQIKSKPQRIPTLEYLSNLTEERKDQFCQESYTFHDIFSICRNSDEIWLPRDKLGISEEEQSFLEKSYHLKFDLNMYSMNLFGDCHLENSHLH
SIO_010081: YLL005C
subclass of: SO_0000673
so part of: YLL005C
location: complement(137940..140546)
location: region:137940-140546:-1
so has part: feature:137940-140546:-1:exon

NP_013096.1
type: Protein
SIO_000068: ncbiprotein

S000003928
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:137940-140546:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1207; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 138185..139164
location: region:138185-139164:1
so has part: feature:138185-139164:1:region

S000130181
type: SGD
SIO_000068: sgd

position:138185:1
position: 138185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:139164:1
position: 139164
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138185-139164:1:region

YLL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ORC3
locus tag: YLL004W
so part of: sequence
location: <141073..>142923
location: region:141073-142923:1
so has part: feature:141073-142923:1:exon
subclass of: SO_0000010

850656
type: Gene
SIO_000068: ncbigene

position:141073:1
position: 141073
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:142923:1
position: 142923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141073-142923:1:exon

YLL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ORC3
locus tag: YLL004W
product: origin recognition complex subunit 3
transcript id: NM_001181824.1
SIO_010081: YLL004W
subclass of: SO_0000673
so part of: YLL004W
location: <141073..>142923
location: region:141073-142923:1
so has part: feature:141073-142923:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141073-142923:1:exon

YLL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ORC3
locus tag: YLL004W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10783164|PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
experiment: EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188]
note: Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
codon start: 1
product: origin recognition complex subunit 3
translation: MSDLNQSKKMNVSEFADAQRSHYTVYPSLPQSNKNDKHIPFVKLLSGKESEVNVEKRWELYHQLHSHFHDQVDHIIDNIEADLKAEISDLLYSETTQKRRCFNTIFLLGSDSTTKIELKDESSRYNVLIELTPKESPNVRMMLRRSMYKLYSAADAEEHPTIKYEDINDEDGDFTEQNNDVSYDLSLVENFKRLFGKDLAMVFNFKDVDSINFNTLDNFIILLKSAFKYDHVKISLIFNINTNLSNIEKNLRQSTIRLLKRNYHKLDVSSNKGFKYGNQIFQSFLDTVDGKLNLSDRFVEFILSKMANNTNHNLQLLTKMLDYSLMSYFFQNAFSVFIDPVNVDFLNDDYLKILSRCPTFMFFVEGLIKQHAPADEILSLLTNKNRGLEEFFVEFLVRENPINGHAKFVARFLEEELNITNFNLIELYHNLLIGKLDSYLDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIFPSYKSNIEDNLLSWEQVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYREANMTINIYDFYIAFRETLPKEEILNFIRKDPSNTKLLELAETPDAFDKVALILFMQAIFAFENMGLIKFQSTKSYDLVEKCVWRGI
SIO_010081: YLL004W
subclass of: SO_0000673
so part of: YLL004W
location: 141073..142923
location: region:141073-142923:1
so has part: feature:141073-142923:1:exon

NP_013097.1
type: Protein
SIO_000068: ncbiprotein

S000003927
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141073-142923:1:exon

YLL003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SFI1
locus tag: YLL003W
so part of: sequence
location: <143201..>146041
location: region:143201-146041:1
so has part: feature:143201-146041:1:exon
subclass of: SO_0000010

850657
type: Gene
SIO_000068: ncbigene

position:143201:1
position: 143201
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:146041:1
position: 146041
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:143201-146041:1:exon

YLL003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SFI1
locus tag: YLL003W
product: Sfi1p
transcript id: NM_001181823.1
SIO_010081: YLL003W
subclass of: SO_0000673
so part of: YLL003W
location: <143201..>146041
location: region:143201-146041:1
so has part: feature:143201-146041:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:143201-146041:1:exon

YLL003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SFI1
locus tag: YLL003W
experiment: EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:14504268]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10455233]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:14504268]
experiment: EXISTENCE:mutant phenotype:GO:0051225 spindle assembly [PMID:17392514]
note: Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C
codon start: 1
product: Sfi1p
translation: MGKFGTTNKSTENLLRDKFVPETSPTNIPTDVLIKQGQITDSTESLIHGGAERYIVNALKPIELNKTEGFFEDPPFHLPSPPVDSTNLEYEDVTDLPKNGLRYDLNDISVEVIEDLYRQIEAFLVHFKLSRSFLQIFKNYVNILIQEGINPLRDEYFTILEDELKGFFTFNSVIEEILEIFLIHPRNKFIALSLAEYTYAKNKIRRHFNHWKTVCELNEEANRFANQAKLRVQEAVFYIWSDKTLKYSQMANDEAESFRNTWLLFRSFQQWITLTQTLKEQSRLADQAFLNKMFRKILKAQEHWKHLETVNTDNIKKIFLRTTFHIWKLRHKEINYHGLERRIFERIKQKVINYEYNKSIAEKVRSFSLQRKYLNKWEKKNIENEDKLGALYELENKFIKQKFFRKLNRSFQHSQQEAIAKSKLNQTLLRCVFEKMWLKRFEDHLHLYSIVSLKEANLVKRIFHSWKKLLYIDLKASDYSRTNLLKSSLRSWKLEVKLKIFEQKCKKSIQASAYRTWRKRIQYGKISSEHVKTAFCAKYLGVWKRRMLQMNSMNDEASKFYEEGLVNECLAIWKERLIKTKELEDRYNFLCKTHAILTVKRTLMHIDNVHLLYTKLAPSMDRVKLSKAFLKWRKATRFKVRHKLNDILHVYEKSKERELQSQLFNAWRNRFCFYTEECNIQAISKRNYQLEKMVLKKFRERLLEIVKSEELADEVREEFVLVKTFYIWKTHLDEIFYMSTLLEQSEANKQFIITSKFLKMWSLRFLKIKRNDETVEVFRHRWDRATVRGLLLLWKNRSDSSPKRRKDFNLKHELKTPIRSDSQNASTIPGSERIKQHRMEAMKSHYSRARRAIPSPVKSSSVLDSTAKKQINLESTTGLNGSPTRGKPLRYSPRRTTRNMPSKVDHIDFGRIPAVPFSLSANSPKIDQDMDYIREHDKSPLSRKRQ
SIO_010081: YLL003W
subclass of: SO_0000673
so part of: YLL003W
location: 143201..146041
location: region:143201-146041:1
so has part: feature:143201-146041:1:exon

NP_013098.1
type: Protein
SIO_000068: ncbiprotein

S000003926
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:143201-146041:1:exon

YLL002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KAT11
alternative label: KIM2
alternative label: REM50
gene: RTT109
locus tag: YLL002W
gene synonym: KAT11; KIM2; REM50
so part of: sequence
location: <146291..>147601
location: region:146291-147601:1
so has part: feature:146291-147601:1:exon
subclass of: SO_0000010

850658
type: Gene
SIO_000068: ncbigene

position:146291:1
position: 146291
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147601:1
position: 147601
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146291-147601:1:exon

YLL002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KAT11
alternative label: KIM2
alternative label: REM50
gene: RTT109
locus tag: YLL002W
gene synonym: KAT11; KIM2; REM50
product: H3 histone acetyltransferase RTT109
transcript id: NM_001181822.1
SIO_010081: YLL002W
subclass of: SO_0000673
so part of: YLL002W
location: <146291..>147601
location: region:146291-147601:1
so has part: feature:146291-147601:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:146291-147601:1:exon

YLL002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KAT11
alternative label: KIM2
alternative label: REM50
gene: RTT109
locus tag: YLL002W
gene synonym: KAT11; KIM2; REM50
EC number: 2.3.1.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010484 histone H3 acetyltransferase activity [PMID:17272722|PMID:17272723]
experiment: EXISTENCE:direct assay:GO:0016573 histone acetylation [PMID:17272723]
experiment: EXISTENCE:genetic interaction:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063]
experiment: EXISTENCE:genetic interaction:GO:0016573 histone acetylation [PMID:17272722|PMID:18458063]
experiment: EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:23593017]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]
experiment: EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]
experiment: EXISTENCE:mutant phenotype:GO:0010484 histone H3 acetyltransferase activity [PMID:17046836|PMID:17272722|PMID:17272723|PMID:18458063]
experiment: EXISTENCE:mutant phenotype:GO:0010526 negative regulation of transposition, RNA-mediated [PMID:11779788]
experiment: EXISTENCE:mutant phenotype:GO:0016573 histone acetylation [PMID:17046836|PMID:17272723|PMID:18458063|PMID:17272722]
experiment: EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]
experiment: EXISTENCE:mutant phenotype:GO:2001032 regulation of double-strand break repair via nonhomologous end joining [PMID:18036332|PMID:27222517]
note: Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p
codon start: 1
product: H3 histone acetyltransferase RTT109
translation: MSLNDFLSSVLPVSEQFEYLSLQSIPLETHAVVTPNKDDKRVPKSTIKTQHFFSLFHQGKVFFSLEVYVYVTLWDEADAERLIFVSKADTNGYCNTRVSVRDITKIILEFILSIDPNYYLQKVKPAIRSYKKISPELISAASTPARTLRILARRLKQSGSTVLKEIESPRFQQDLYLSFTCPREILTKICLFTRPASQYLFPDSSKNSKKHILNGEELMKWWGFILDRLLIECFQNDTQAKLRIPGEDPARVRSYLRGMKYPLWQVGDIFTSKENSLAVYNIPLFPDDPKARFIHQLAEEDRLLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLATPSLFPSSADVIVPKSRKQFRAIKKYITGEEYDTEEGAIEAFTNIRDFLLLRMATNLQSLTGKREHRERNQPVPASNINTLAITMLKPRKKAKALPKT
SIO_010081: YLL002W
subclass of: SO_0000673
so part of: YLL002W
location: 146291..147601
location: region:146291-147601:1
so has part: feature:146291-147601:1:exon

NP_013099.1
type: Protein
SIO_000068: ncbiprotein

S000003925
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:146291-147601:1:exon

YLL001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DNM1
locus tag: YLL001W
so part of: sequence
location: <147890..>150163
location: region:147890-150163:1
so has part: feature:147890-150163:1:exon
subclass of: SO_0000010

850686
type: Gene
SIO_000068: ncbigene

position:147890:1
position: 147890
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150163:1
position: 150163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:147890-150163:1:exon

YLL001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DNM1
locus tag: YLL001W
product: dynamin-related GTPase DNM1
transcript id: NM_001181821.1
SIO_010081: YLL001W
subclass of: SO_0000673
so part of: YLL001W
location: <147890..>150163
location: region:147890-150163:1
so has part: feature:147890-150163:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:147890-150163:1:exon

YLL001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DNM1
locus tag: YLL001W
EC number: 3.6.5.5
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16186251]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11038182]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16968746]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16272155]
experiment: EXISTENCE:direct assay:GO:0042802 identical protein binding [PMID:16186251]
experiment: EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:17336903]
experiment: EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:10559943]
experiment: EXISTENCE:genetic interaction:GO:0007031 peroxisome organization [PMID:16968746]
experiment: EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]
experiment: EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:23341591]
experiment: EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:10559943]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:16272155]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:9786946]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:16968746]
experiment: EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:32265272]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy
codon start: 1
product: dynamin-related GTPase DNM1
translation: MASLEDLIPTVNKLQDVMYDSGIDTLDLPILAVVGSQSSGKSSILETLVGRDFLPRGTGIVTRRPLVLQLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRFYDFDDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQIKNLILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMDSGTNALDILSGKMYPLKLGFVGVVNRSQQDIQLNKTVEESLDKEEDYFRKHPVYRTISTKCGTRYLAKLLNQTLLSHIRDKLPDIKTKLNTLISQTEQELARYGGVGATTNESRASLVLQLMNKFSTNFISSIDGTSSDINTKELCGGARIYYIYNNVFGNSLKSIDPTSNLSVLDVRTAIRNSTGPRPTLFVPELAFDLLVKPQIKLLLEPSQRCVELVYEELMKICHKCGSAELARYPKLKSMLIEVISELLRERLQPTRSYVESLIDIHRAYINTNHPNFLSATEAMDDIMKTRRKRNQELLKSKLSQQENGQTNGINGTSSISSNIDQDSAKNSDYDDDGIDAESKQTKDKFLNYFFGKDKKGQPVFDASDKKRSIAGDGNIEDFRNLQISDFSLGDIDDLENAEPPLTEREELECELIKRLIVSYFDIIREMIEDQVPKAVMCLLVNYCKDSVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVKSLGVYKKAATLISNIL
SIO_010081: YLL001W
subclass of: SO_0000673
so part of: YLL001W
location: 147890..150163
location: region:147890-150163:1
so has part: feature:147890-150163:1:exon

NP_013100.1
type: Protein
SIO_000068: ncbiprotein

S000003924
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:147890-150163:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN12; Chromosome XII centromere
so part of: sequence
location: complement(150828..150947)
location: region:150828-150947:-1
so has part: feature:150828-150947:-1:region

S000006473
type: SGD
SIO_000068: sgd

position:150828:-1
position: 150828
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:150947:-1
position: 150947
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150828-150947:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN12_CDEIII of CEN12
so part of: sequence
location: complement(150828..150852)
location: region:150828-150852:-1
so has part: feature:150828-150852:-1:region

position:150852:-1
position: 150852
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150828-150852:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN12_CDEII of CEN12
so part of: sequence
location: complement(150853..150937)
location: region:150853-150937:-1
so has part: feature:150853-150937:-1:region

position:150853:-1
position: 150853
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:150937:-1
position: 150937
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150853-150937:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN12_CDEI of CEN12
so part of: sequence
location: complement(150938..150947)
location: region:150938-150947:-1
so has part: feature:150938-150947:-1:region

position:150938:-1
position: 150938
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150938-150947:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1208; Autonomously Replicating Sequence
so part of: sequence
location: 150947..151389
location: region:150947-151389:1
so has part: feature:150947-151389:1:region

S000114848
type: SGD
SIO_000068: sgd

position:150947:1
position: 150947
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:151389:1
position: 151389
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150947-151389:1:region

YLR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR001C
so part of: sequence
location: complement(<151389..>153977)
location: region:151389-153977:-1
so has part: feature:151389-153977:-1:exon
subclass of: SO_0000010

850687
type: Gene
SIO_000068: ncbigene

position:151389:-1
position: 151389
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:153977:-1
position: 153977
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151389-153977:-1:exon

YLR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR001C
product: uncharacterized protein
transcript id: NM_001181888.1
SIO_010081: YLR001C
subclass of: SO_0000673
so part of: YLR001C
location: complement(<151389..>153977)
location: region:151389-153977:-1
so has part: feature:151389-153977:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:151389-153977:-1:exon

YLR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR001C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
codon start: 1
product: uncharacterized protein
translation: MNMAIQTIKYIFWLLPILGLTQALLQNPGDDFPFSTVIDILSENVEFSTFLRIIQKTGHVQYLNELQNFTLFAPINSAFIKGDQTTDQFEEHFHIEDFLIHDRVLQVRDLENGTYLEKRAAKAPLLLRKHERHCFVNEIAVVEPDLLPSFQNASLQGINNLLLIQPQINELLVQLDEETQDLKIFSDFISSFSNYNAYTNSSTVLVPLDVNFRKFFNTIEINYLLDKYNKLGKSNTISQAKWAADRTSLLQELIIDDVYGGILPKELILENKNNRKLFMKSNSEGTSVSVNNSDYSPISNRIFEIGVVHGFSDLDFLRTHIQFDAEKYLHGLNCSEFVKELYFRDLEKFIQNGRKITIFVPQASFNEDRGYTKPSLLYHFVEGKIDLEQDFSSLRPIQYAPTQIYDSAFCSSAKRLGGHCQKFKITRSNKGYYINGRFKILNTKPYEIGNTSIYSIDDDLQLPGDLVLSLAPENHCSISLMLLKELNLLDLPSNHKGYTILLPCMNSWDNNDLTIDYLRSNKTALNLLMRNLIFEDLIYSNNYSISTTVKNLYGNSVSIGVQKIVGSQNLTKISVSTIKESIIIEESSDIFFNQGVIHPIDQLDFPVDLEISLKELIETTGTKEIFDFFNLFYDLSSIIWNNEEYSLLVPTASSIPLSGITANSTNLRKFLELHLIPANVTQNLLDCNGSISTKLGTKLNCRKDHLDNVFVSIQGDWTKEVRVLKTGCTTNLKSSCIFLIDKPISLSWLNSEKYHLRLPGIAVGFGVIIGVTIAISLLFCIIITRGGKVKDKNQRGRNDRATTPLIQHSPIIHNPSYSATAHLSPLSQPTFEGSYSVNAIQTPRDIRRVGSDQKGGRSVSTS
SIO_010081: YLR001C
subclass of: SO_0000673
so part of: YLR001C
location: complement(151389..153977)
location: region:151389-153977:-1
so has part: feature:151389-153977:-1:exon

NP_013101.1
type: Protein
SIO_000068: ncbiprotein

S000003991
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:151389-153977:-1:exon

YLR002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOC3
locus tag: YLR002C
so part of: sequence
location: complement(<154343..>156334)
location: region:154343-156334:-1
so has part: feature:154343-156334:-1:exon
subclass of: SO_0000010

850688
type: Gene
SIO_000068: ncbigene

position:154343:-1
position: 154343
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:156334:-1
position: 156334
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:154343-156334:-1:exon

YLR002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOC3
locus tag: YLR002C
product: Noc3p
transcript id: NM_001181889.1
SIO_010081: YLR002C
subclass of: SO_0000673
so part of: YLR002C
location: complement(<154343..>156334)
location: region:154343-156334:-1
so has part: feature:154343-156334:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:154343-156334:-1:exon

YLR002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOC3
locus tag: YLR002C
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12110182]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12110182]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11371346]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:22421151]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11371346]
experiment: EXISTENCE:direct assay:GO:0006270 DNA replication initiation [PMID:12110182]
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:12110182]
experiment: EXISTENCE:direct assay:GO:0030691 Noc2p-Noc3p complex [PMID:11371346]
experiment: EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11371346]
note: Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
codon start: 1
product: Noc3p
translation: MAKRNRSQFRIQERTAKKRKHEDSLLEGNVFQNAPEDMDENTIYSAKGSSWDEEEQDYEMVPRKNRSDTSNLVEGLPIKVNGKVERKLHKAQEKPKDDDEEDEDSNDSSEDDEGPNEEQEAEAKEDEPDTEEKILQLKEDIADLVTKVMEEPEENTAALGRLCKMVESKNPNTCKFSMLALVPVFKSIIPGYRIRPLTETEKKEKVSKEVSKLRNFEQALVYNYKNYVGRLQSLSKTPSNAAPIQVSLGILATQAAKELISTASHFNFRTDIFTLLLRRICKPRISTDPTSIQIIQTFETLLNEDEEGSISFEILRIFNKILKTRNFNIEESVLNMLLSLDVLHDYDPNTKLKGNVSAPKLKKKDRVHLSKKQRKARKEMQQIEEEMRNAEQAVSAEERERNQSEILKIVFTIYLNILKNNAKTLIGSVLEGLTKFGNMANFDLLGDFLEVMKELISDTEFDNLSSAEVRKALLCIVSAFSLISNTQYMKVNVDLSKFVDGLYALLPYICLDADIELSYRSLRLADPLNNEIIKPSVNVSTKAELLLKALDHVFFRSKSGTKERATAFTKRLYMCISHTPEKTSIAILKFIDKLMNRYPEISGLYSSEDRIGNGHFIMEADNPSRSNPEAATLWDNALLEKHYCPVVTKGLRSLSSRSKECSK
SIO_010081: YLR002C
subclass of: SO_0000673
so part of: YLR002C
location: complement(154343..156334)
location: region:154343-156334:-1
so has part: feature:154343-156334:-1:exon

NP_013102.1
type: Protein
SIO_000068: ncbiprotein

S000003992
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:154343-156334:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1209; Autonomously Replicating Sequence
so part of: sequence
location: 156648..156884
location: region:156648-156884:1
so has part: feature:156648-156884:1:region

S000118470
type: SGD
SIO_000068: sgd

position:156648:1
position: 156648
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:156884:1
position: 156884
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156648-156884:1:region

YLR003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CMS1
locus tag: YLR003C
so part of: sequence
location: complement(<156855..>157730)
location: region:156855-157730:-1
so has part: feature:156855-157730:-1:exon
subclass of: SO_0000010

850689
type: Gene
SIO_000068: ncbigene

position:156855:-1
position: 156855
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157730:-1
position: 157730
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156855-157730:-1:exon

YLR003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CMS1
locus tag: YLR003C
product: Cms1p
transcript id: NM_001181890.1
SIO_010081: YLR003C
subclass of: SO_0000673
so part of: YLR003C
location: complement(<156855..>157730)
location: region:156855-157730:-1
so has part: feature:156855-157730:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:156855-157730:-1:exon

YLR003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CMS1
locus tag: YLR003C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
note: Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: Cms1p
translation: MSNPDDLDDGLAYDFDAEHEVIFDAKDGSPPTKKVQKRSIEQDDDDVDDIDGKKEERNSEDDSNRPISKRQKKLQKKSKLIEKKKEESQYIVSQRKALPASSPEKIIEYLTTLIREKNPDLSVLELEELYFKRNDFLSTEKFDAERRLSNFPAFIQKFSVAPKKIVFSMSNIRVADVYRSLNGGKNCVKLFSKSKLKDDIATVERLLTDSSKKSNKNKDSLYFIATPTRMQKIIEATDLLFQGKEKLDIILDASYLDPKDNTILSFENAAVLCQVLKTFLNKKSSVKILLY
SIO_010081: YLR003C
subclass of: SO_0000673
so part of: YLR003C
location: complement(156855..157730)
location: region:156855-157730:-1
so has part: feature:156855-157730:-1:exon

NP_013103.1
type: Protein
SIO_000068: ncbiprotein

S000003993
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:156855-157730:-1:exon

YLR004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THI73
locus tag: YLR004C
so part of: sequence
location: complement(<157934..>159505)
location: region:157934-159505:-1
so has part: feature:157934-159505:-1:exon
subclass of: SO_0000010

850690
type: Gene
SIO_000068: ncbigene

position:157934:-1
position: 157934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159505:-1
position: 159505
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:157934-159505:-1:exon

YLR004C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THI73
locus tag: YLR004C
product: Thi73p
transcript id: NM_001181891.1
SIO_010081: YLR004C
subclass of: SO_0000673
so part of: YLR004C
location: complement(<157934..>159505)
location: region:157934-159505:-1
so has part: feature:157934-159505:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:157934-159505:-1:exon

YLR004C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THI73
locus tag: YLR004C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16850348]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
codon start: 1
product: Thi73p
translation: MKNMSQRSMDVEKKAANADSCSVSTSSINVDDADVALRFLKQNGLDESSTANEDDVVAGEEANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFSNLGTIFSAAYIFMEPVVTYLIQKFPISKILGTFITVWGIVLACHAACKTYASLMVVRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGTAFTSWQIMFLVVGLVTVAFGVLTFLYLPDNVTNAWFLNKEEKIQVVEHIRANQTGLETKKFKKQQVKELFLHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKYETALLQLPIGAITAMIILITTQMLSRWGHITLITTSMYIPAIIGCIVLISLPLSHKIGNLFSLYLLYSGSCVITNIYIWNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQMFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRDKEQEGQERKKYQFLDLTDIENRNFRYIY
SIO_010081: YLR004C
subclass of: SO_0000673
so part of: YLR004C
location: complement(157934..159505)
location: region:157934-159505:-1
so has part: feature:157934-159505:-1:exon

NP_013104.1
type: Protein
SIO_000068: ncbiprotein

S000003994
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:157934-159505:-1:exon

YLR005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSL1
locus tag: YLR005W
so part of: sequence
location: <160049..>161434
location: region:160049-161434:1
so has part: feature:160049-161434:1:exon
subclass of: SO_0000010

850691
type: Gene
SIO_000068: ncbigene

position:160049:1
position: 160049
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:161434:1
position: 161434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160049-161434:1:exon

YLR005W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSL1
locus tag: YLR005W
product: TFIIH/NER complex subunit SSL1
transcript id: NM_001181892.1
SIO_010081: YLR005W
subclass of: SO_0000673
so part of: YLR005W
location: <160049..>161434
location: region:160049-161434:1
so has part: feature:160049-161434:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160049-161434:1:exon

YLR005W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSL1
locus tag: YLR005W
experiment: EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]
experiment: EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:19818408|PMID:14500720]
experiment: EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:15837426]
experiment: EXISTENCE:direct assay:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:19450536|PMID:19679665]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7891722]
note: Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p
codon start: 1
product: TFIIH/NER complex subunit SSL1
translation: MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKKRLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQRGIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT
SIO_010081: YLR005W
subclass of: SO_0000673
so part of: YLR005W
location: 160049..161434
location: region:160049-161434:1
so has part: feature:160049-161434:1:exon

NP_013105.1
type: Protein
SIO_000068: ncbiprotein

S000003995
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160049-161434:1:exon

YLR006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSK1
locus tag: YLR006C
so part of: sequence
location: complement(<161755..>163893)
location: region:161755-163893:-1
so has part: feature:161755-163893:-1:exon
subclass of: SO_0000010

850692
type: Gene
SIO_000068: ncbigene

position:161755:-1
position: 161755
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:163893:-1
position: 163893
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:161755-163893:-1:exon

YLR006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSK1
locus tag: YLR006C
product: mitogen-activated protein kinase kinase kinase SSK1
transcript id: NM_001181893.1
SIO_010081: YLR006C
subclass of: SO_0000673
so part of: YLR006C
location: complement(<161755..>163893)
location: region:161755-163893:-1
so has part: feature:161755-163893:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:161755-163893:-1:exon

YLR006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSK1
locus tag: YLR006C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14665464]
experiment: EXISTENCE:direct assay:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]
experiment: EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:9482735]
experiment: EXISTENCE:direct assay:GO:0031954 positive regulation of protein autophosphorylation [PMID:9482735]
experiment: EXISTENCE:direct assay:GO:0071474 cellular hyperosmotic response [PMID:9482735]
experiment: EXISTENCE:direct assay:GO:0140531 regulation of osmosensory signaling MAPK cascade [PMID:9482735]
experiment: EXISTENCE:genetic interaction:GO:0140531 regulation of osmosensory signaling MAPK cascade [PMID:9482735]
experiment: EXISTENCE:mutant phenotype:GO:0000156 phosphorelay response regulator activity [PMID:8183345]
experiment: EXISTENCE:mutant phenotype:GO:0030295 protein kinase activator activity [PMID:9482735]
experiment: EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:18573873]
experiment: EXISTENCE:mutant phenotype:GO:0140531 regulation of osmosensory signaling MAPK cascade [PMID:18573873]
experiment: EXISTENCE:mutant phenotype:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:19633059]
experiment: EXISTENCE:physical interaction:GO:0031435 mitogen-activated protein kinase kinase kinase binding [PMID:9482735]
note: Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
codon start: 1
product: mitogen-activated protein kinase kinase kinase SSK1
translation: MLNSALLWKVWLRIDNSTDEVNQPIAVQFDEIDTVDDLKSRFFQKLSSTRWREINDNASIAIGLYAPKFDNQADNTSSNNTNDNSCRSKSNGAGSGANLSVNSNTKSSVSPTAGSFGLSKDLAKDRNVLQHPKPTQKRGALYDAFAAVPTVAATTNVDFPPNEAPMLSPQRPYSTSPKQFPATTKSPLLRFASVSPYPKFHSDNQIMASAGLTYVSPHNKNKYTRPLIRKGLNFTTESVNDCTYKIIFEPDELAINIYKELFGTMGSQPASQPLLIFSNVNLRQDVPPLDILNVVDYVPTNEEISQQKTQPTDHGAVGVFHLDDHISPGEQGLKQTIGDKADLKGKDGNSSPQEFKLITDEEQLRRASQELKDEEKDAESPWQAILLLPKGYKGGVDFRNKPVAHTDSSFNNEDTITHSELEVNTGSPSQESGSLNEAGIGITQPMSEVQRRKEDVTPASPILTSSQTPHYSNSLYNAPFAVSSPPDPLPNLFTTTSEKVFPKINVLIVEDNVINQAILGSFLRKHKISYKLAKNGQEAVNIWKEGGLHLIFMDLQLPVLSGIEAAKQIRDFEKQNGIGIQKSLNNSHSNLEKGTSKRFSQAPVIIVALTASNSQMDKRKALLSGCNDYLTKPVNLHWLSKKITEWGCMQALIDFDSWKQGESRMTDSVLVKSPQKPIAPSNPHSFKQATSMTPTHSPVRKNSNLSPTQIEL
SIO_010081: YLR006C
subclass of: SO_0000673
so part of: YLR006C
location: complement(161755..163893)
location: region:161755-163893:-1
so has part: feature:161755-163893:-1:exon

NP_013106.1
type: Protein
SIO_000068: ncbiprotein

S000003996
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:161755-163893:-1:exon

YLR007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSE1
locus tag: YLR007W
so part of: sequence
location: <164392..>165402
location: region:164392-165402:1
so has part: feature:164392-165402:1:exon
subclass of: SO_0000010

850693
type: Gene
SIO_000068: ncbigene

position:164392:1
position: 164392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:165402:1
position: 165402
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164392-165402:1:exon

YLR007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSE1
locus tag: YLR007W
product: Smc5-Smc6 complex subunit NSE1
transcript id: NM_001181894.1
SIO_010081: YLR007W
subclass of: SO_0000673
so part of: YLR007W
location: <164392..>165402
location: region:164392-165402:1
so has part: feature:164392-165402:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164392-165402:1:exon

YLR007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSE1
locus tag: YLR007W
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11927594]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11927594]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:17923688]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]
note: Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
codon start: 1
product: Smc5-Smc6 complex subunit NSE1
translation: MEVHEEQVSAPVTGDATAKYLLQYILSARGICHENALILALMRLETDASTLNTEWSIQQWVDKLNDYINAINVKLNLLGYKIIRINHGIGRNAVTLKAKQNFESFEDNTAIRAHNNDYAVLQSIVLPESNRFFVYVNLASTEETKLATRFNQNEIEFMKWAIEQFMISGETIVEGPALETSIIVKEVNRILVAATGDSNLAKWRKFSTFTVGSTNLFQFQELTATDIEDLLLRLCELKWFYRTQEGKFGIDLRCIAELEEYLTSMYNLNTCQNCHKLAIQGVRCGNESCREENEETGENSLSQIWHVDCFKHYITHVSKNCDRCGSSLITEGVYVI
SIO_010081: YLR007W
subclass of: SO_0000673
so part of: YLR007W
location: 164392..165402
location: region:164392-165402:1
so has part: feature:164392-165402:1:exon

NP_013107.1
type: Protein
SIO_000068: ncbiprotein

S000003997
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164392-165402:1:exon

YLR008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TIM14
gene: PAM18
locus tag: YLR008C
gene synonym: TIM14
so part of: sequence
location: complement(<165577..>166083)
location: region:165577-166083:-1
so has part: feature:165577-166083:-1:exon
subclass of: SO_0000010

850694
type: Gene
SIO_000068: ncbigene

position:165577:-1
position: 165577
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:166083:-1
position: 166083
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:165577-166083:-1:exon

YLR008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TIM14
gene: PAM18
locus tag: YLR008C
gene synonym: TIM14
product: Pam18p
transcript id: NM_001181895.1
SIO_010081: YLR008C
subclass of: SO_0000673
so part of: YLR008C
location: complement(<165577..>166083)
location: region:165577-166083:-1
so has part: feature:165577-166083:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:165577-166083:-1:exon

YLR008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TIM14
gene: PAM18
locus tag: YLR008C
gene synonym: TIM14
experiment: EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14638855]
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16027163]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:14517234]
experiment: EXISTENCE:mutant phenotype:GO:0001671 ATPase activator activity [PMID:14605210|PMID:14638855]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:14517234|PMID:14638855|PMID:14605210]
note: Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
codon start: 1
product: Pam18p
translation: MSSQSNTGNSIEAPQLPIPGQTNGSANVTVDGAGVNVGIQNGSQGQKTGMDLYFDQALNYMGEHPVITGFGAFLTLYFTAGAYKSISKGLNGGKSTTAFLKGGFDPKMNSKEALQILNLTENTLTKKKLKEVHRKIMLANHPDKGGSPFLATKINEAKDFLEKRGISK
SIO_010081: YLR008C
subclass of: SO_0000673
so part of: YLR008C
location: complement(165577..166083)
location: region:165577-166083:-1
so has part: feature:165577-166083:-1:exon

NP_013108.1
type: Protein
SIO_000068: ncbiprotein

S000003998
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:165577-166083:-1:exon

YLR009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RLP24
locus tag: YLR009W
so part of: sequence
location: <166537..>167136
location: region:166537-167136:1
so has part: feature:166537-167136:1:exon
subclass of: SO_0000010

850695
type: Gene
SIO_000068: ncbigene

position:166537:1
position: 166537
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167136:1
position: 167136
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:166537-167136:1:exon

YLR009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RLP24
locus tag: YLR009W
product: ATPase-activating ribosome biosynthesis protein
transcript id: NM_001181896.1
SIO_010081: YLR009W
subclass of: SO_0000673
so part of: YLR009W
location: <166537..>167136
location: region:166537-167136:1
so has part: feature:166537-167136:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:166537-167136:1:exon

YLR009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RLP24
locus tag: YLR009W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23185031]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20670889]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
experiment: EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]
note: Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
codon start: 1
product: ATPase-activating ribosome biosynthesis protein
translation: MRIYQCHFCSSPCYPGHGIMFVRNDAKEFRFCRSKCHKAFKQRRNPRKLKWTKAFRKAAGKELAVDSTLTFAQRRNVPVRYNRELVATTLKAMARIEEIRQKRERAFYKNRMRGNKEKDFLRDKKLVESNPELLRIREVEIARKLAKEQERAESVSEQEESEEEEEDMEIDSDEEEEEQLEKQKILLKNRRRNTKKIAF
SIO_010081: YLR009W
subclass of: SO_0000673
so part of: YLR009W
location: 166537..167136
location: region:166537-167136:1
so has part: feature:166537-167136:1:exon

NP_013109.1
type: Protein
SIO_000068: ncbiprotein

S000003999
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:166537-167136:1:exon

YLR010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TEN1
locus tag: YLR010C
so part of: sequence
location: complement(<167320..>167802)
location: region:167320-167802:-1
so has part: feature:167320-167802:-1:exon
subclass of: SO_0000010

850696
type: Gene
SIO_000068: ncbigene

position:167320:-1
position: 167320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167802:-1
position: 167802
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167320-167802:-1:exon

YLR010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TEN1
locus tag: YLR010C
product: Ten1p
transcript id: NM_001181897.1
SIO_010081: YLR010C
subclass of: SO_0000673
so part of: YLR010C
location: complement(<167320..>167802)
location: region:167320-167802:-1
so has part: feature:167320-167802:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167320-167802:-1:exon

YLR010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TEN1
locus tag: YLR010C
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17293872]
experiment: EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]
experiment: EXISTENCE:genetic interaction:GO:0007004 telomere maintenance via telomerase [PMID:11230140]
experiment: EXISTENCE:genetic interaction:GO:0016233 telomere capping [PMID:11230140]
experiment: EXISTENCE:mutant phenotype:GO:0003711 transcription elongation factor activity [PMID:31006804]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:31006804]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:11230140]
experiment: EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:11230140]
experiment: EXISTENCE:mutant phenotype:GO:0032205 negative regulation of telomere maintenance [PMID:19532124]
experiment: EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140]
note: Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex
codon start: 1
product: Ten1p
translation: MSQLVLDLKCLKDKIATNYDIHNNVYGGNGMEPNIIHPSKRFRIVVRLVDFLFCKSDEEFIKGFFCQMIVRNLHCLNSTNGAEEMRLYMSERLFSAHKDDLRLINGQVLDVRIGVWYGIHQSPPIFEIIDFKILSRNDVRDFCEFVKSPLGEKFLNISNS
SIO_010081: YLR010C
subclass of: SO_0000673
so part of: YLR010C
location: complement(167320..167802)
location: region:167320-167802:-1
so has part: feature:167320-167802:-1:exon

NP_013110.1
type: Protein
SIO_000068: ncbiprotein

S000004000
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167320-167802:-1:exon

YNCL0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0002C
so part of: sequence
location: complement(167944..168025)
location: region:167944-168025:-1
so has part: feature:167944-168025:-1:exon
subclass of: SO_0000663

850697
type: Gene
SIO_000068: ncbigene

position:167944:-1
position: 167944
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:168025:-1
position: 168025
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167944-168025:-1:exon

YNCL0002C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0002C
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCL0002C
subclass of: SO_0000673
so part of: YNCL0002C
location: complement(167944..168025)
location: region:167944-168025:-1
so has part: feature:167944-168025:-1:exon

S000006728
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167944-168025:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(168043..168380)
location: region:168043-168380:-1
so has part: feature:168043-168380:-1:region

S000007079
type: SGD
SIO_000068: sgd

position:168043:-1
position: 168043
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:168380:-1
position: 168380
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168043-168380:-1:region

YLR011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LOT6
locus tag: YLR011W
so part of: sequence
location: <169103..>169678
location: region:169103-169678:1
so has part: feature:169103-169678:1:exon
subclass of: SO_0000010

850698
type: Gene
SIO_000068: ncbigene

position:169103:1
position: 169103
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:169678:1
position: 169678
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169103-169678:1:exon

YLR011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LOT6
locus tag: YLR011W
product: flavin-dependent quinone reductase
transcript id: NM_001181898.1
SIO_010081: YLR011W
subclass of: SO_0000673
so part of: YLR011W
location: <169103..>169678
location: region:169103-169678:1
so has part: feature:169103-169678:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:169103-169678:1:exon

YLR011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LOT6
locus tag: YLR011W
EC number: 1.5.1.39
experiment: EXISTENCE:direct assay:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:17298444]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17298444|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17298444]
experiment: EXISTENCE:direct assay:GO:0042994 cytoplasmic sequestering of transcription factor [PMID:19029946]
experiment: EXISTENCE:mutant phenotype:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:17298444]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:19709309]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17298444]
note: FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
codon start: 1
product: flavin-dependent quinone reductase
translation: MKVGIIMGSVRAKRVCPEIAAYVKRTIENSEELIDQKLKIQVVDLQQIALPLYEDDDELIPAQIKSVDEYADSKTRSWSRIVNALDIIVFVTPQYNWGYPAALKNAIDRLYHEWHGKPALVVSYGGHGGSKCNDQLQEVLHGLKMNVIGGVAVKIPVGTIPLPEDIVPQLSVHNEEILQLLASCIETTRNK
SIO_010081: YLR011W
subclass of: SO_0000673
so part of: YLR011W
location: 169103..169678
location: region:169103-169678:1
so has part: feature:169103-169678:1:exon

NP_013111.1
type: Protein
SIO_000068: ncbiprotein

S000004001
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:169103-169678:1:exon

YLR012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR012C
so part of: sequence
location: complement(<169982..>170281)
location: region:169982-170281:-1
so has part: feature:169982-170281:-1:exon
subclass of: SO_0000010

850699
type: Gene
SIO_000068: ncbigene

position:169982:-1
position: 169982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:170281:-1
position: 170281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169982-170281:-1:exon

YLR012C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR012C
product: uncharacterized protein
transcript id: NM_001181899.1
SIO_010081: YLR012C
subclass of: SO_0000673
so part of: YLR012C
location: complement(<169982..>170281)
location: region:169982-170281:-1
so has part: feature:169982-170281:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:169982-170281:-1:exon

YLR012C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR012C
note: hypothetical protein; YLR012C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MKTVYYKEITYQQYLQLQPEQQEKYLALCQKDFEQETERIAFDRQGGVPGIARKFAQEEVAWFDRVTTWSYMNAYIPSYRRRRNLLKIDMLKMSNAEEY
SIO_010081: YLR012C
subclass of: SO_0000673
so part of: YLR012C
location: complement(169982..170281)
location: region:169982-170281:-1
so has part: feature:169982-170281:-1:exon

NP_013112.2
type: Protein
SIO_000068: ncbiprotein

S000004002
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:169982-170281:-1:exon

YLR013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAT3
locus tag: YLR013W
so part of: sequence
location: <171339..>171764
location: region:171339-171764:1
so has part: feature:171339-171764:1:exon
subclass of: SO_0000010

850700
type: Gene
SIO_000068: ncbigene

position:171339:1
position: 171339
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171764:1
position: 171764
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171339-171764:1:exon

YLR013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAT3
locus tag: YLR013W
product: Gat3p
transcript id: NM_001181900.1
SIO_010081: YLR013W
subclass of: SO_0000673
so part of: YLR013W
location: <171339..>171764
location: region:171339-171764:1
so has part: feature:171339-171764:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171339-171764:1:exon

YLR013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAT3
locus tag: YLR013W
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]
note: Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants
codon start: 1
product: Gat3p
translation: MNIKTLCHPEYKRISVESLLNPVEETIDCEKPHSQTKINTAKPISASLYVTTNNTAVVQHNVQKRKGVTRRCPQCAVIKTSPQWREGPDGEVTLCNACGLFYRKIFLVFGKDLAKRYFNEIKGVSVKRKVPKSLYGVTRTR
SIO_010081: YLR013W
subclass of: SO_0000673
so part of: YLR013W
location: 171339..171764
location: region:171339-171764:1
so has part: feature:171339-171764:1:exon

NP_013113.1
type: Protein
SIO_000068: ncbiprotein

S000004003
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171339-171764:1:exon

YLR014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPR1
locus tag: YLR014C
so part of: sequence
location: complement(<172268..>174982)
location: region:172268-174982:-1
so has part: feature:172268-174982:-1:exon
subclass of: SO_0000010

850701
type: Gene
SIO_000068: ncbigene

position:172268:-1
position: 172268
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174982:-1
position: 174982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172268-174982:-1:exon

YLR014C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPR1
locus tag: YLR014C
product: Ppr1p
transcript id: NM_001181901.1
SIO_010081: YLR014C
subclass of: SO_0000673
so part of: YLR014C
location: complement(<172268..>174982)
location: region:172268-174982:-1
so has part: feature:172268-174982:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172268-174982:-1:exon

YLR014C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPR1
locus tag: YLR014C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9858611]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9858611]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:7843415]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7958913]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2204810]
experiment: EXISTENCE:mutant phenotype:GO:1900399 positive regulation of pyrimidine nucleotide biosynthetic process [PMID:24189721]
note: Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
codon start: 1
product: Ppr1p
translation: MKQKKFNSKKSNRTDLSKRGDSPNIGISKSRTACKRCRLKKIKCDQEFPSCKRCAKLEVPCVSLDPATGKDVPRSYVFFLEDRLAVMMRVLKEYGVDPTKIRGNIPATSDDEPFDLKKYSSVSSLGEEGILPHNGLLADYLVQKGNSMASSAITSKSMASPQTINVQRKEFLVNSKKQDGSALLPETGSPMTSDARAEELRRCNKEISALGTMRESSFNSFLGDSSGISFAKLVFTATNFRQDSGDDVLDEDIKQREQKYNGYAEAENNPHFDPLELPPRHAAEVMISRFFVDTNSQLPLLHRELFLKKYFEPIYGPWNPNIALASDQTGINSAFEIPITSAFSAHTEPKRENVTEKIDVCSSVDVPWYDTWETSQKVNMRPIVELPTKFHIPYFFLNIIFAIGHATQVLKSDITTVATYKRRATKYIASLFSSSDRLEALAGTLLMVIYSIMRPNVPGVWYTMGSVLRLTVDLGLHSEKINKNYDAFTREIRRRLFWCVYSLDRQICSYFGRPFGIPEESITTRYPSLLDDSFITLTNREIDDYSDLPSPNPSSKVIALAMYKIRRIQASIVRILYAPGAELPRRFMDLESWRIETYNELERWFQVDVPKNFEMMNCKFNSIWFDLNYHYSKSILYGLSPKFPTLNDTAFKIVLDSTKGTIDVFYNLCVNKKIGYTWVAVHNMFMTGMTYLYVNFYSKNNINDCQEKVSEYTEKVLIVLKNLIGFCESAKTCYTSYKILSSVVIKLKFMQINDAKGIFSDSNPLTSQANRMSSYDKKTNVLGFDDGTFDNKVFNRTNFEEKAPFDIPLDEFFTELEKHSNVSQFNTLDVSEGNQVINESASTNTSSALNCQSYTNNQDIMDILFQVTSGSVWDEFFVRSGNGNEGESSYDISKGKNSESGGIF
SIO_010081: YLR014C
subclass of: SO_0000673
so part of: YLR014C
location: complement(172268..174982)
location: region:172268-174982:-1
so has part: feature:172268-174982:-1:exon

NP_013114.1
type: Protein
SIO_000068: ncbiprotein

S000004004
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172268-174982:-1:exon

YLR015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPS60
gene: BRE2
locus tag: YLR015W
gene synonym: CPS60
so part of: sequence
location: <175227..>176744
location: region:175227-176744:1
so has part: feature:175227-176744:1:exon
subclass of: SO_0000010

850702
type: Gene
SIO_000068: ncbigene

position:175227:1
position: 175227
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:176744:1
position: 176744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175227-176744:1:exon

YLR015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPS60
gene: BRE2
locus tag: YLR015W
gene synonym: CPS60
product: Bre2p
transcript id: NM_001181902.1
SIO_010081: YLR015W
subclass of: SO_0000673
so part of: YLR015W
location: <175227..>176744
location: region:175227-176744:1
so has part: feature:175227-176744:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175227-176744:1:exon

YLR015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPS60
gene: BRE2
locus tag: YLR015W
gene synonym: CPS60
experiment: EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]
experiment: EXISTENCE:direct assay:GO:0051568 histone H3-K4 methylation [PMID:11742990|PMID:11752412|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11687631|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11752412|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0051568 histone H3-K4 methylation [PMID:11752412|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0080182 histone H3-K4 trimethylation [PMID:16921172|PMID:16980427]
experiment: EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11742990|PMID:11752412]
note: Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
codon start: 1
product: Bre2p
translation: MKLGIIPYQEGTDIVYKNALQGQQEGKRPNLPQMEATHQIKSSVQGTSYEFVRTEDIPLNRRHFVYRPCSANPFFTILGYGCTEYPFDHSGMSVMDRSEGLSISRDGNDLVSVPDQYGWRTARSDVCIKEGMTYWEVEVIRGGNKKFADGVNNKENADDSVDEVQSGIYEKMHKQVNDTPHLRFGVCRREASLEAPVGFDVYGYGIRDISLESIHEGKLNCVLENGSPLKEGDKIGFLLSLPSIHTQIKQAKEFTKRRIFALNSHMDTMNEPWREDAENGPSRKKLKQETTNKEFQRALLEDIEYNDVVRDQIAIRYKNQLFFEATDYVKTTKPEYYSSDKRERQDYYQLEDSYLAIFQNGKYLGKAFENLKPLLPPFSELQYNEKFYLGYWQHGEARDESNDKNTTSAKKKKQQQKKKKGLILRNKYVNNNKLGYYPTISCFNGGTARIISEEDKLEYLDQIRSAYCVDGNSKVNTLDTLYKEQIAEDIVWDIIDELEQIALQQ
SIO_010081: YLR015W
subclass of: SO_0000673
so part of: YLR015W
location: 175227..176744
location: region:175227-176744:1
so has part: feature:175227-176744:1:exon

NP_013115.1
type: Protein
SIO_000068: ncbiprotein

S000004005
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175227-176744:1:exon

YLR016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PML1
locus tag: YLR016C
so part of: sequence
location: complement(<176802..>177416)
location: region:176802-177416:-1
so has part: feature:176802-177416:-1:exon
subclass of: SO_0000010

850703
type: Gene
SIO_000068: ncbigene

position:176802:-1
position: 176802
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:177416:-1
position: 177416
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:176802-177416:-1:exon

YLR016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PML1
locus tag: YLR016C
product: Pml1p
transcript id: NM_001181903.1
SIO_010081: YLR016C
subclass of: SO_0000673
so part of: YLR016C
location: complement(<176802..>177416)
location: region:176802-177416:-1
so has part: feature:176802-177416:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:176802-177416:-1:exon

YLR016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PML1
locus tag: YLR016C
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:15565172]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0070274 RES complex [PMID:15565172]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:15565172]
experiment: EXISTENCE:mutant phenotype:GO:0051237 maintenance of RNA location [PMID:16162818]
note: Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
codon start: 1
product: Pml1p
translation: MFHRRKRPYNTRNYGHDDKKFKSQYIDIMPDFSPSGLLELESNNKEGIALKHVEPQDAISPDNYMDMLGLEARDRTMYELVIYRKNDKDKGPWKRYDLNGRSCYLVGRELGHSLDTDLDDRTEIVVADIGIPEETSSKQHCVIQFRNVRGILKCYVMDLDSSNGTCLNNVVIPGARYIELRSGDVLTLSEFEEDNDYELIFMNV
SIO_010081: YLR016C
subclass of: SO_0000673
so part of: YLR016C
location: complement(176802..177416)
location: region:176802-177416:-1
so has part: feature:176802-177416:-1:exon

NP_013116.1
type: Protein
SIO_000068: ncbiprotein

S000004006
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:176802-177416:-1:exon

YLR017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MEU1
locus tag: YLR017W
so part of: sequence
location: <177608..>178621
location: region:177608-178621:1
so has part: feature:177608-178621:1:exon
subclass of: SO_0000010

850704
type: Gene
SIO_000068: ncbigene

position:177608:1
position: 177608
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:178621:1
position: 178621
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:177608-178621:1:exon

YLR017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MEU1
locus tag: YLR017W
product: S-methyl-5-thioadenosine phosphorylase
transcript id: NM_001181904.1
SIO_010081: YLR017W
subclass of: SO_0000673
so part of: YLR017W
location: <177608..>178621
location: region:177608-178621:1
so has part: feature:177608-178621:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:177608-178621:1:exon

YLR017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MEU1
locus tag: YLR017W
EC number: 2.4.2.28
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8807288]
experiment: EXISTENCE:direct assay:GO:0017061 S-methyl-5-thioadenosine phosphorylase activity [PMID:14506228]
experiment: EXISTENCE:direct assay:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:14506228]
experiment: EXISTENCE:mutant phenotype:GO:0006537 glutamate biosynthetic process [PMID:8807288]
experiment: EXISTENCE:mutant phenotype:GO:0017061 S-methyl-5-thioadenosine phosphorylase activity [PMID:14506228]
experiment: EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:14506228|PMID:18625006]
note: Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
codon start: 1
product: S-methyl-5-thioadenosine phosphorylase
translation: MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEFMHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW
SIO_010081: YLR017W
subclass of: SO_0000673
so part of: YLR017W
location: 177608..178621
location: region:177608-178621:1
so has part: feature:177608-178621:1:exon

NP_013117.1
type: Protein
SIO_000068: ncbiprotein

S000004007
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:177608-178621:1:exon

YLR018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POM34
locus tag: YLR018C
so part of: sequence
location: complement(<178707..>179606)
location: region:178707-179606:-1
so has part: feature:178707-179606:-1:exon
subclass of: SO_0000010

850705
type: Gene
SIO_000068: ncbigene

position:178707:-1
position: 178707
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:179606:-1
position: 179606
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178707-179606:-1:exon

YLR018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POM34
locus tag: YLR018C
product: Pom34p
transcript id: NM_001181905.1
SIO_010081: YLR018C
subclass of: SO_0000673
so part of: YLR018C
location: complement(<178707..>179606)
location: region:178707-179606:-1
so has part: feature:178707-179606:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178707-179606:-1:exon

YLR018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POM34
locus tag: YLR018C
experiment: EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:16361228]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:10684247|PMID:19414609]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:16361228]
experiment: EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]
experiment: EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:19571182|PMID:20713690]
experiment: EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:16361228]
experiment: EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]
note: Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
codon start: 1
product: Pom34p
translation: MKIQAGQLGLDDNDVPGPLPDTDSKPSSQSQNDTPMFKLGNFESPVLKELSRRTVNKEMETQRIMTNVIAFAFWNLLVKFIKFFWNNTHVGRQFCNRLSRIHLYMLTFHTLKKANIIYHTTFSWLNAELLDYLFHLLISLNILFSLWKLLSTVKVSDLNLTDRQKKLLGVDMQSSVDTGLQPQHPHYVSTSKISQMAQNKTHIPQTNLKNHPAYLFKGLETPLKARQREMAEEQTKLQSQSLHTKNVFGTLQRHSGISSTLVSANNDNNSPHTPVTRKGYIPSSKYAYMMNSQSPRGKI
SIO_010081: YLR018C
subclass of: SO_0000673
so part of: YLR018C
location: complement(178707..179606)
location: region:178707-179606:-1
so has part: feature:178707-179606:-1:exon

NP_013118.1
type: Protein
SIO_000068: ncbiprotein

S000004008
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178707-179606:-1:exon

YLR019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSR2
locus tag: YLR019W
so part of: sequence
location: <180288..>181481
location: region:180288-181481:1
so has part: feature:180288-181481:1:exon
subclass of: SO_0000010

850706
type: Gene
SIO_000068: ncbigene

position:180288:1
position: 180288
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181481:1
position: 181481
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180288-181481:1:exon

YLR019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSR2
locus tag: YLR019W
product: putative phosphatase
transcript id: NM_001181906.1
SIO_010081: YLR019W
subclass of: SO_0000673
so part of: YLR019W
location: <180288..>181481
location: region:180288-181481:1
so has part: feature:180288-181481:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180288-181481:1:exon

YLR019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSR2
locus tag: YLR019W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12090248]
experiment: EXISTENCE:genetic interaction:GO:0071472 cellular response to salt stress [PMID:10777497]
experiment: EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]
note: Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases
codon start: 1
product: putative phosphatase
translation: MGFIANILCCSSDTSKTHRQRQPPETNHNRNRNRKHSSNKAQTQGRKQKATPNGDKMQYSTPEILLSSSDSGSNAGSKTMQENGNSGNGKLAPLSRDHSNNSYDEEKEYEDYNEGDVEMTEVNNAGEEEEEDDEAKEKQDHVVHEYNVDADRNSSINDEAPPQQGLYQVGQEDMNPQYVASSPDNDLNLIPTTEEDFSDLTHLQPDQYHAPGYDTLLPPKLQEFQQKKCLILDLDETLVHSSFKYMHSADFVLPVEIDDQVHNVYVIKRPGVDEFLNRVSQLYEVVVFTASVSRYANPLLDTLDPNGTIHHRLFREACYNYEGNYIKNLSQIGRPLSETIILDNSPASYIFHPQHAVPISSWFSDTHDNELLDIIPLLEDLSSGNVLDVGSVLDVTI
SIO_010081: YLR019W
subclass of: SO_0000673
so part of: YLR019W
location: 180288..181481
location: region:180288-181481:1
so has part: feature:180288-181481:1:exon

NP_013119.1
type: Protein
SIO_000068: ncbiprotein

S000004009
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180288-181481:1:exon

YLR020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YEH2
locus tag: YLR020C
so part of: sequence
location: complement(<181789..>183405)
location: region:181789-183405:-1
so has part: feature:181789-183405:-1:exon
subclass of: SO_0000010

850707
type: Gene
SIO_000068: ncbigene

position:181789:-1
position: 181789
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:183405:-1
position: 183405
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181789-183405:-1:exon

YLR020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YEH2
locus tag: YLR020C
product: sterol esterase
transcript id: NM_001181907.1
SIO_010081: YLR020C
subclass of: SO_0000673
so part of: YLR020C
location: complement(<181789..>183405)
location: region:181789-183405:-1
so has part: feature:181789-183405:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181789-183405:-1:exon

YLR020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YEH2
locus tag: YLR020C
EC number: 3.1.1.13
experiment: EXISTENCE:direct assay:GO:0004771 sterol esterase activity [PMID:15632184|PMID:15713625]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15632184]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:14587103]
experiment: EXISTENCE:mutant phenotype:GO:0004771 sterol esterase activity [PMID:15632184]
experiment: EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15632184|PMID:15713625]
note: Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication
codon start: 1
product: sterol esterase
translation: MVNKVVDEVQRLVSAIILTSFMTGLFILSLWKNYVTVHFQHKNDPRDTRSSRTKIQPNDKKKKRPARHSRPLSISSTTPLDLQRDQENNIEYDRTVTSKLSMTSNASLSENGDGNANIKMETNVNQAPYAAENPFQNIALAEDTKLVPDLKYYYKEYGIDIEEFEVETDDGFIIDLWHFKSRLNDGVEEVKREPILLLHGLLQSCGAFASSGRKSLAYFLYESGFDVWLGNNRCGLNAKWNMKKLGNDHSKKWDWDMHQMVQYDLKALINYVLDSTGYAKLSLVAHSQGTTQGFMGLVNGEKLYASDFKLVDKLENFVALAPAVYPGPLLDEKAFVRLMAKGIDSPWYFGRRSFIPLMMTMRKLMVGTKIFSFLSYIMFNYLFDWNDVLWDRVLRDRNFLFSPVHISVKLMQWWLSPLPNKLSFKKGAEKIFPDKKTWFPIAKNDDDSGNNLDNNKLHLNPKRQNSEEFPHIIMFIPKQDRLVDGERLINHFINHEANAVYKIWYIDEYSHLDVLWAHDVIDRIGKPMIENLRFPNAR
SIO_010081: YLR020C
subclass of: SO_0000673
so part of: YLR020C
location: complement(181789..183405)
location: region:181789-183405:-1
so has part: feature:181789-183405:-1:exon

NP_013120.1
type: Protein
SIO_000068: ncbiprotein

S000004010
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181789-183405:-1:exon

YLR021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DMP2
alternative label: PBA3
alternative label: POC3
gene: IRC25
locus tag: YLR021W
gene synonym: DMP2; PBA3; POC3
so part of: sequence
location: <183623..>184162
location: region:183623-184162:1
so has part: feature:183623-184162:1:exon
subclass of: SO_0000010

850708
type: Gene
SIO_000068: ncbigene

position:183623:1
position: 183623
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184162:1
position: 184162
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:183623-184162:1:exon

YLR021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DMP2
alternative label: PBA3
alternative label: POC3
gene: IRC25
locus tag: YLR021W
gene synonym: DMP2; PBA3; POC3
product: Irc25p
transcript id: NM_001181908.1
SIO_010081: YLR021W
subclass of: SO_0000673
so part of: YLR021W
location: <183623..>184162
location: region:183623-184162:1
so has part: feature:183623-184162:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:183623-184162:1:exon

YLR021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DMP2
alternative label: PBA3
alternative label: POC3
gene: IRC25
locus tag: YLR021W
gene synonym: DMP2; PBA3; POC3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17707236]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17707236]
experiment: EXISTENCE:genetic interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]
experiment: EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:18278055|PMID:18260085]
experiment: EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]
experiment: EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]
experiment: EXISTENCE:physical interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:18278055]
note: Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)
codon start: 1
product: Irc25p
translation: MISYEFQTHLPKGKDSSLNASSENKELYVQATHFNNTILLQIRLNGEMDSTYEVSSKGLNPILDINVPLAGNLGNTGGDYDDEEEEFVRDHLSDYQVVTKLGDSADPKVPVVCVQIAELYRRVILPEVSGTMAQDNMQFSLLISMSSKIWRATKEQSADDNDFGKLVFVLKCIKDMYAK
SIO_010081: YLR021W
subclass of: SO_0000673
so part of: YLR021W
location: 183623..184162
location: region:183623-184162:1
so has part: feature:183623-184162:1:exon

NP_013121.1
type: Protein
SIO_000068: ncbiprotein

S000004011
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:183623-184162:1:exon

YLR022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDO1
locus tag: YLR022C
so part of: sequence
location: complement(<184174..>184926)
location: region:184174-184926:-1
so has part: feature:184174-184926:-1:exon
subclass of: SO_0000010

850709
type: Gene
SIO_000068: ncbigene

position:184174:-1
position: 184174
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184926:-1
position: 184926
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184174-184926:-1:exon

YLR022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDO1
locus tag: YLR022C
product: guanine nucleotide exchange factor SDO1
transcript id: NM_001181909.1
SIO_010081: YLR022C
subclass of: SO_0000673
so part of: YLR022C
location: complement(<184174..>184926)
location: region:184174-184926:-1
so has part: feature:184174-184926:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184174-184926:-1:exon

YLR022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDO1
locus tag: YLR022C
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:23831625]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:19350533]
experiment: EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:19350533]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:19350533]
experiment: EXISTENCE:direct assay:GO:1990932 5.8S rRNA binding [PMID:19350533]
experiment: EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:17353896]
note: Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
codon start: 1
product: guanine nucleotide exchange factor SDO1
translation: MPINQPSGQIKLTNVSLVRLKKARKRFEVACYQNKVQDYRKGIEKDLDEVLQIHQVFMNVSKGLVANKEDLQKCFGTTNVDDVIEEIMHKGEIQLSEKERQLMLNKVNNEMLTIVSAKCINPVSKKRYPPTMIHKALQELKFSPVINKPAKLQALEAIKLLVSKQIIPIVRAKMKVKVAISEPSRQPELIEKISKLIASSPGESTKPELDPWTCTGLIDPVNYRDLMTLCDKKGTVQVLDMAVIDNTTHN
SIO_010081: YLR022C
subclass of: SO_0000673
so part of: YLR022C
location: complement(184174..184926)
location: region:184174-184926:-1
so has part: feature:184174-184926:-1:exon

NP_013122.1
type: Protein
SIO_000068: ncbiprotein

S000004012
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184174-184926:-1:exon

YLR023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IZH3
locus tag: YLR023C
so part of: sequence
location: complement(<185498..>187129)
location: region:185498-187129:-1
so has part: feature:185498-187129:-1:exon
subclass of: SO_0000010

850710
type: Gene
SIO_000068: ncbigene

position:185498:-1
position: 185498
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187129:-1
position: 187129
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185498-187129:-1:exon

YLR023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IZH3
locus tag: YLR023C
product: Izh3p
transcript id: NM_001181910.1
SIO_010081: YLR023C
subclass of: SO_0000673
so part of: YLR023C
location: complement(<185498..>187129)
location: region:185498-187129:-1
so has part: feature:185498-187129:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185498-187129:-1:exon

YLR023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IZH3
locus tag: YLR023C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006882 cellular zinc ion homeostasis [PMID:15060275]
note: Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
codon start: 1
product: Izh3p
translation: MMDSSSKSLTQYIPSPMGSLSRLKQKGVDNFQKVKKSGKSIYNYNYSKFVPHPFSTIDESVKHSESGRYDDLEIIRPTKEKEVTSSVYKRNSGKSLNTESQFSLGDSDAATLVNSVATFKLNNASTSTSLVSSSSTVCSQAKSSLRSPTSRLNDTKIKEENNYISSVKDYCGPMRKSMVKTEILIEEPLNPTTDIKSFINSYNHGKAYSLGETQHLHYYQLPFPWRENRYIIHGYRFYNTHSKSLLSIFNWYGWHNETSNIWSHLLGAIYIIYLAIYDFPQSEVWRNSQVPPQARWIVFMFLAAALKCMLSSVFWHTFNGTSFLKLRSKFACVDYSGITILITASILTTEFVTMYSCYWAMYTYMSISLALGVFGVFMNWSPRFDRPEARPLRIRFFILLATMGVLSFLHLIFLTDLHYAATLFSPVTYKSVVWYLVGVVFYGSFIPERFRSDVQVDKTIPTNYELSTDLEIITKQREIHFREVPTAHSKCSSCPSHAKSFKSLWWVDYFGCSHTFWHFFVVLGVIGHYRAILDMFAKRWILS
SIO_010081: YLR023C
subclass of: SO_0000673
so part of: YLR023C
location: complement(185498..187129)
location: region:185498-187129:-1
so has part: feature:185498-187129:-1:exon

NP_013123.1
type: Protein
SIO_000068: ncbiprotein

S000004013
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185498-187129:-1:exon

YLR024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBR2
locus tag: YLR024C
so part of: sequence
location: complement(<187663..>193281)
location: region:187663-193281:-1
so has part: feature:187663-193281:-1:exon
subclass of: SO_0000010

850711
type: Gene
SIO_000068: ncbigene

position:187663:-1
position: 187663
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:193281:-1
position: 193281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187663-193281:-1:exon

YLR024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBR2
locus tag: YLR024C
product: putative ubiquitin-protein ligase UBR2
transcript id: NM_001181911.2
SIO_010081: YLR024C
subclass of: SO_0000673
so part of: YLR024C
location: complement(<187663..>193281)
location: region:187663-193281:-1
so has part: feature:187663-193281:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187663-193281:-1:exon

YLR024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBR2
locus tag: YLR024C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:15504724]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:15504724]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]
experiment: EXISTENCE:genetic interaction:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:15504724]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:15504724]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724|PMID:18070918]
experiment: EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]
note: Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex
codon start: 1
product: putative ubiquitin-protein ligase UBR2
translation: MEDSDLSITNIRDFLTELPKLAKCEYSETTSYLLWKTLNLRLKHSDNDINWRSLVSILNSEAWENEKYRDILNGRKWRTLEFENDHHSVGNMHIGTACTRLCFPSETIYYCFTCSTNPLYEICELCFDKEKHVNHSYVAKVVMRPEGRICHCGDPFAFNDPSDAFKCKNELNNIPISNDNSNVTDDENVISLLNYVLDFLIDVTVSYKEEAEAHSSERKASSLMHPNQNSITDDIMEKHECEPLVNDENFVFFDNNWSNTRKEAHMEWAIQIEEEECNVHYMDLASTITRILNTPVEYAISITKALEDSHDVVTVLQSENFFEIDQIAKEFQKENIVVHVRKADDIFKRKLTDDLTDWLYSLCFKAATSLQNKYALRISMLDVWYSHFSKMRVSPTNTNPDFSKINLLGGFLISNEDSDESWFKPWSLENIEDERISKILTNYNERLIRAHSPNTVSHFYNFYGSRFQYIIINSINILSKKSKFKMLKIMASLFSLRDESRKFLAAQYIDVYLSVLYDAVASDAKECQVTLMSILGQYTFQDPSIANMTISSGFIERTIRFAFTLMAFNPEDLMSYLPISLYNGFKLPTETIRNRRTIICFKDLCTIMSANTVPEELLSNEAIFNAIIESFSEFSNVLPLKRETKEHVEVENFDFSAFYFFFSSILIMTDGYTRSISLVKDAAFRKQIVLKLLDVAQTREFESLTNSRKAISPDNASTNENDSNKATLSTVRETICNYVAETINFQVGVNTQYFFNPMSYLFKFVIQWSQCGRYEPIPASLTNYINLFEVFQDKQKALYISESALSTLVLIGQINVGFWVRNGTPITHQARMYTKYSMREFTYISDIFNVQFSMAMCNPDELMVTYLSRWGLKHWANGVPMYDYPDTETTVAVVNECILLLIQLLTEVRSLVMKSSKEGFERTFKSEIIHALCFDTCSYAQIVNCIPEHITKHPSFDIYLEKYANYTSPVSLTDNGIFVLKEKYKDEIDPYYIGLSSSRRYDVEKNIRLNMANLKKMKYEDTFVPAKKVKDLLKNTLFSGLYSISSVNTFGLFLKNTLDHIIKYDYDNLLPRVVHLIHLCVVNNLNEFMGILWHEYAIVDTEFCHYHSIGSILYYCLLKDNFSESHGKIREIFRYLMETAPHVNVNSYLREQTTSYTPGILWPTKEDKSHKDKEFERKKHLARLRKKKLMKKLAQQQMKFMENNSVDTSDISTPRTTSPSLSPTRINAENSSNTINSCCDDDCVFCKMPKDDDVFVYFSYQERNICDHGIDFTNPTDVNRINSLFSGKQTKDSAIQENPQDDDGTRLKFTSCEPVLRACGHGSHTKCLSGHMKSIRGIQNQTTKNIPLSYGSGLIYCPVCNSLSNSFLPKTNDIDKRTSSQFFMCIEKRSEAEENLDPMSSICIKAAMILGDLQGKKVTTIEDAYKVVNSVFINTISNTELRLRSHKKEGKIVNMERISSQCILTLHLVCELKSFIYKKFVNSKTFSSEISRKIWNWNEFLIKGNNVNLLLYMSQNFDNIDGGKTPQPPNLCIYEMFKRRFHQLLLLLARDMMRVNFYKDCRNKIKISSNGSEEPSTSFSYLFNTFKKYVDLFKPDDVRFDFTSLEKIKDFICSLLLESLSIFCRRTFLLFNIQYDDDGDGDNNNNRSNNFMDVKQREIELIFRYFKLPNLTHFLKDFFYNELTQNIERYNDGNDNLRIQQVIYDMVQNINTRAYPSPEHIQLIELPLNLSKFSLDNDEISNKCDKYEIAVCLLCGQKCHIQKSIALQGYLQGECTDHMRNGCEITSAYGVFLMTGTNAIYLSYGKRGTFYAAPYLSKYGETNEDYKFGTPVYLNRARYANLANEIVFGNMIPHIVFRLTDGSADLGGWETM
SIO_010081: YLR024C
subclass of: SO_0000673
so part of: YLR024C
location: complement(187663..193281)
location: region:187663-193281:-1
so has part: feature:187663-193281:-1:exon

NP_013124.1
type: Protein
SIO_000068: ncbiprotein

S000004014
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187663-193281:-1:exon

YLR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DID1
alternative label: RNS4
alternative label: VPL5
alternative label: VPS32
gene: SNF7
locus tag: YLR025W
gene synonym: DID1; RNS4; VPL5; VPS32
so part of: sequence
location: <194452..>195174
location: region:194452-195174:1
so has part: feature:194452-195174:1:exon
subclass of: SO_0000010

850712
type: Gene
SIO_000068: ncbigene

position:194452:1
position: 194452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:195174:1
position: 195174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194452-195174:1:exon

YLR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DID1
alternative label: RNS4
alternative label: VPL5
alternative label: VPS32
gene: SNF7
locus tag: YLR025W
gene synonym: DID1; RNS4; VPL5; VPS32
product: ESCRT-III subunit protein SNF7
transcript id: NM_001181912.1
SIO_010081: YLR025W
subclass of: SO_0000673
so part of: YLR025W
location: <194452..>195174
location: region:194452-195174:1
so has part: feature:194452-195174:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194452-195174:1:exon

YLR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DID1
alternative label: RNS4
alternative label: VPL5
alternative label: VPS32
gene: SNF7
locus tag: YLR025W
gene synonym: DID1; RNS4; VPL5; VPS32
experiment: EXISTENCE:curator inference:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15086794]
experiment: EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9606181]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27803246]
experiment: EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]
experiment: EXISTENCE:direct assay:GO:1904902 ESCRT III complex assembly [PMID:31273031]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9606181]
experiment: EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]
experiment: EXISTENCE:mutant phenotype:GO:0071454 cellular response to anoxia [PMID:20402793]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15086794|PMID:27074665]
note: One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III
codon start: 1
product: ESCRT-III subunit protein SNF7
translation: MWSSLFGWTSSNAKNKESPTKAIVRLREHINLLSKKQSHLRTQITNQENEARIFLTKGNKVMAKNALKKKKTIEQLLSKVEGTMESMEQQLFSIESANLNLETMRAMQEGAKAMKTIHSGLDIDKVDETMDEIREQVELGDEISDAISRPLITGANEVDEDELDEELDMLAQENANQETSKIVNNNVNAAPISENKVSLPSVPSNKIKQSENSVKDGEEEEDEEDEDEKALRELQAEMGL
SIO_010081: YLR025W
subclass of: SO_0000673
so part of: YLR025W
location: 194452..195174
location: region:194452-195174:1
so has part: feature:194452-195174:1:exon

NP_013125.1
type: Protein
SIO_000068: ncbiprotein

S000004015
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194452-195174:1:exon

YLR026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SED5
locus tag: YLR026C
so part of: sequence
location: complement(<195450..>196472)
location: region:195450-196472:-1
so has part: feature:195450-196472:-1:exon
subclass of: SO_0000010

850713
type: Gene
SIO_000068: ncbigene

position:195450:-1
position: 195450
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196472:-1
position: 196472
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:195450-196472:-1:exon

YLR026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SED5
locus tag: YLR026C
product: t-SNARE syntaxin
transcript id: NM_001181913.1
SIO_010081: YLR026C
subclass of: SO_0000673
so part of: YLR026C
location: complement(<195450..>196472)
location: region:195450-196472:-1
so has part: feature:195450-196472:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:195450-196472:-1:exon

YLR026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SED5
locus tag: YLR026C
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11001058|PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:9725919]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:1400588]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058|PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0090083 regulation of inclusion body assembly [PMID:31433985]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9545229]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:7596416]
experiment: EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:9545229]
note: cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi
codon start: 1
product: t-SNARE syntaxin
translation: MNIKDRTSEFQQSVLSYKKRNKNFREQQRERLQEKESENFANNTTGNGKSVSEFQKKASGIAHEISSTAQLLSKLAVLAKRKPMFNDNPVEIAELSFLIKRKIYAIEQSLVQLSQLKKTDVNGNTSNQSSKQPSAVQHSKNVVNLLNTQMKNISGSFKDVLEERQRLEMANKDRWQKLTTDTGHAPADDQTQSNHAADLTTYNNSNPFMTSLLDESSEKNNNSSNQGELSFPQNDSQLMLMEEGQLSNNVYLQERNRAVETIESTIQEVGNLFQQLASMVQEQGEVIQRIDANVDDIDLNISGAQRELLKYFDRIKSNRWLAAKVFFIIFVFFVIWVLVN
SIO_010081: YLR026C
subclass of: SO_0000673
so part of: YLR026C
location: complement(195450..196472)
location: region:195450-196472:-1
so has part: feature:195450-196472:-1:exon

NP_013126.1
type: Protein
SIO_000068: ncbiprotein

S000004016
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:195450-196472:-1:exon

YLR027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASP5
gene: AAT2
locus tag: YLR027C
gene synonym: ASP5
so part of: sequence
location: complement(<196829..>198085)
location: region:196829-198085:-1
so has part: feature:196829-198085:-1:exon
subclass of: SO_0000010

850714
type: Gene
SIO_000068: ncbigene

position:196829:-1
position: 196829
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:198085:-1
position: 198085
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196829-198085:-1:exon

YLR027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASP5
gene: AAT2
locus tag: YLR027C
gene synonym: ASP5
product: aspartate transaminase AAT2
transcript id: NM_001181914.1
SIO_010081: YLR027C
subclass of: SO_0000673
so part of: YLR027C
location: complement(<196829..>198085)
location: region:196829-198085:-1
so has part: feature:196829-198085:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196829-198085:-1:exon

YLR027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASP5
gene: AAT2
locus tag: YLR027C
gene synonym: ASP5
EC number: 2.6.1.1
experiment: EXISTENCE:direct assay:GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity [PMID:1859361]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9288922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9288922]
experiment: EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:35621265]
experiment: EXISTENCE:mutant phenotype:GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity [PMID:9288922]
experiment: EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:9288922]
experiment: EXISTENCE:mutant phenotype:GO:0006532 aspartate biosynthetic process [PMID:9288922|PMID:15780654]
experiment: EXISTENCE:mutant phenotype:GO:0032938 negative regulation of translation in response to oxidative stress [PMID:35621265]
note: Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress
codon start: 1
product: aspartate transaminase AAT2
translation: MSATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDAFQEDRVISVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNWDHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYVAKAIDEVVRFYTIEAKL
SIO_010081: YLR027C
subclass of: SO_0000673
so part of: YLR027C
location: complement(196829..198085)
location: region:196829-198085:-1
so has part: feature:196829-198085:-1:exon

NP_013127.2
type: Protein
SIO_000068: ncbiprotein

S000004017
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196829-198085:-1:exon

YNCL0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR30
locus tag: YNCL0003W
so part of: sequence
location: 198784..199389
location: region:198784-199389:1
so has part: feature:198784-199389:1:exon
subclass of: SO_0000578

9164925
type: Gene
SIO_000068: ncbigene

position:198784:1
position: 198784
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:199389:1
position: 199389
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198784-199389:1:exon

YNCL0003W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR30
locus tag: YNCL0003W
product: SNR30
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8455623]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:8455623]
experiment: EXISTENCE:direct assay:GO:0051099 positive regulation of binding [PMID:24130456]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14749391|PMID:8455623]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:2898766|PMID:15923376|PMID:9472021]
note: H/ACA box small nucleolar RNA (snoRNA); essential gene required for cleavage of 35S primary rRNA transcript to release the precursor to the 18S rRNA
transcript id: NR_132204.1
SIO_010081: YNCL0003W
subclass of: SO_0000673
so part of: YNCL0003W
location: 198784..199389
location: region:198784-199389:1
so has part: feature:198784-199389:1:exon

S000007497
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198784-199389:1:exon

YLR028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADE16
locus tag: YLR028C
so part of: sequence
location: complement(<199540..>201315)
location: region:199540-201315:-1
so has part: feature:199540-201315:-1:exon
subclass of: SO_0000010

850715
type: Gene
SIO_000068: ncbigene

position:199540:-1
position: 199540
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201315:-1
position: 201315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:199540-201315:-1:exon

YLR028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADE16
locus tag: YLR028C
product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
transcript id: NM_001181915.1
SIO_010081: YLR028C
subclass of: SO_0000673
so part of: YLR028C
location: complement(<199540..>201315)
location: region:199540-201315:-1
so has part: feature:199540-201315:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:199540-201315:-1:exon

YLR028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADE16
locus tag: YLR028C
EC number: 2.1.2.3
EC number: 3.5.4.10
experiment: EXISTENCE:direct assay:GO:0003937 IMP cyclohydrolase activity [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]
experiment: EXISTENCE:direct assay:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]
experiment: EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]
experiment: EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]
note: Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
codon start: 1
product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16
translation: MGKYTKTAILSVYDKTGLLDLAKGLVENNVRILASGGTANMVREAGFPVDDVSSITHAPEMLGGRVKTLHPAVHAGILARNLEGDEKDLKEQHIDKVDFVVCNLYPFKETVAKIGVTVQEAVEEIDIGGVTLLRAAAKNHSRVTILSDPNDYSIFLQDLSKDGEISQDLRNRFALKAFEHTADYDAAISDFFRKQYSEGKAQLPLRYGCNPHQRPAQAYITQQEELPFKVLCGTPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVERQVYFVNDMEDLSPLACAYARARGADRMSSFGDFIALSNIVDVATAKIISKEVSDGVIAPGYEPEALNILSKKKNGKYCILQIDPNYVPGQMESREVFGVTLQQKRNDAIINQSTFKEIVSKNKALTEQAVIDLTVATLVLKYTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDKTDNWWLRQHPKVLNMKWAKGIKRADKSNAIDLFVTGQRIEGPEKVDYESKFEEVPEPFTKEERLEWLSKLNNVSLSSDAFFPFPDNVYRAVQSGVKFITAPSGSVMDKVVFQAADSFDIVYVENPIRLFHH
SIO_010081: YLR028C
subclass of: SO_0000673
so part of: YLR028C
location: complement(199540..201315)
location: region:199540-201315:-1
so has part: feature:199540-201315:-1:exon

NP_013128.1
type: Protein
SIO_000068: ncbiprotein

S000004018
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:199540-201315:-1:exon

YLR029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL10A
gene: RPL15A
locus tag: YLR029C
gene synonym: RPL10A
so part of: sequence
location: complement(<201976..>202590)
location: region:201976-202590:-1
so has part: feature:201976-202590:-1:exon
subclass of: SO_0000010

850716
type: Gene
SIO_000068: ncbigene

position:201976:-1
position: 201976
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:202590:-1
position: 202590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:201976-202590:-1:exon

YLR029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL10A
gene: RPL15A
locus tag: YLR029C
gene synonym: RPL10A
product: ribosomal 60S subunit protein L15A
transcript id: NM_001181916.1
SIO_010081: YLR029C
subclass of: SO_0000673
so part of: YLR029C
location: complement(<201976..>202590)
location: region:201976-202590:-1
so has part: feature:201976-202590:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:201976-202590:-1:exon

YLR029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL10A
gene: RPL15A
locus tag: YLR029C
gene synonym: RPL10A
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]
note: Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L15A
translation: MGAYKYLEELQRKKQSDVLRFLQRVRVWEYRQKNVIHRAARPTRPDKARRLGYKAKQGFVIYRVRVRRGNRKRPVPKGATYGKPTNQGVNELKYQRSLRATAEERVGRRAANLRVLNSYWVNQDSTYKYFEVILVDPQHKAIRRDARYNWICDPVHKHREARGLTATGKKSRGINKGHKFNNTKAGRRKTWKRQNTLSLWRYRK
SIO_010081: YLR029C
subclass of: SO_0000673
so part of: YLR029C
location: complement(201976..202590)
location: region:201976-202590:-1
so has part: feature:201976-202590:-1:exon

NP_013129.1
type: Protein
SIO_000068: ncbiprotein

S000004019
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:201976-202590:-1:exon

YLR030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR030W
so part of: sequence
location: <203290..>204081
location: region:203290-204081:1
so has part: feature:203290-204081:1:exon
subclass of: SO_0000010

850717
type: Gene
SIO_000068: ncbigene

position:203290:1
position: 203290
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204081:1
position: 204081
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:203290-204081:1:exon

YLR030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR030W
product: uncharacterized protein
transcript id: NM_001181917.1
SIO_010081: YLR030W
subclass of: SO_0000673
so part of: YLR030W
location: <203290..>204081
location: region:203290-204081:1
so has part: feature:203290-204081:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:203290-204081:1:exon

YLR030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR030W
note: hypothetical protein; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W
codon start: 1
product: uncharacterized protein
translation: MEGEQIMEYVQETPIIPKRIIHYSIPKQMITKPAPHVEMTLVANTFRDMDLPQHPVIHDCWQNKEYSTQRYSGNVAQQRLSFEEHPNEECQNSVGLIKRVSTFFKKRPLSRKNSIKSIGDVKSEARNRGEGLLGEVDNLNEQNVRENLTSEHEKSPEGDSKRYGLFSFEETPPIQVLEQGNINSELSSFKNTSLAENKRSSDSFVSLKPGEDEHSPLEISTCGNLTEREDLQSGEERFDSAAQNIKVASMKEKKKIFKGNKTD
SIO_010081: YLR030W
subclass of: SO_0000673
so part of: YLR030W
location: 203290..204081
location: region:203290-204081:1
so has part: feature:203290-204081:1:exon

NP_013130.1
type: Protein
SIO_000068: ncbiprotein

S000004020
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:203290-204081:1:exon

YLR031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR031W
so part of: sequence
location: <204225..>204785
location: region:204225-204785:1
so has part: feature:204225-204785:1:exon
subclass of: SO_0000010

850718
type: Gene
SIO_000068: ncbigene

position:204225:1
position: 204225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204785:1
position: 204785
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204225-204785:1:exon

YLR031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR031W
product: uncharacterized protein
transcript id: NM_001181918.1
SIO_010081: YLR031W
subclass of: SO_0000673
so part of: YLR031W
location: <204225..>204785
location: region:204225-204785:1
so has part: feature:204225-204785:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:204225-204785:1:exon

YLR031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR031W
note: hypothetical protein; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MPVLNTRTSYPNIDFHGTKVSDVLDAFEFEKHDDPLRDKWNTLQFLEKSFESKFESASELIQGGELAAIKERNFQLAKLNNLCFRVRESIKRRQDLEKKLRTLSQDTDNELLFLMLENERRKKSSVIIEFLSEIIREKSKRLTAEEQGFVNQNEVKPLILDLSARINRLNSILETKNTCIRRLSNQ
SIO_010081: YLR031W
subclass of: SO_0000673
so part of: YLR031W
location: 204225..204785
location: region:204225-204785:1
so has part: feature:204225-204785:1:exon

NP_013131.1
type: Protein
SIO_000068: ncbiprotein

S000004021
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:204225-204785:1:exon

YLR032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: REV2
alternative label: SNM2
gene: RAD5
locus tag: YLR032W
gene synonym: REV2; SNM2
so part of: sequence
location: <204991..>208500
location: region:204991-208500:1
so has part: feature:204991-208500:1:exon
subclass of: SO_0000010

850719
type: Gene
SIO_000068: ncbigene

position:204991:1
position: 204991
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:208500:1
position: 208500
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204991-208500:1:exon

YLR032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: REV2
alternative label: SNM2
gene: RAD5
locus tag: YLR032W
gene synonym: REV2; SNM2
product: DNA helicase RAD5
transcript id: NM_001181919.1
SIO_010081: YLR032W
subclass of: SO_0000673
so part of: YLR032W
location: <204991..>208500
location: region:204991-208500:1
so has part: feature:204991-208500:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:204991-208500:1:exon

YLR032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: REV2
alternative label: SNM2
gene: RAD5
locus tag: YLR032W
gene synonym: REV2; SNM2
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:19706603]
experiment: EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:17936713]
experiment: EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:17936713]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24393774]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006301 postreplication repair [PMID:17936713]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:17936713]
experiment: EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:17936713]
experiment: EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]
experiment: EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:18757916]
experiment: EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:18757916]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:16224103]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16224103]
experiment: EXISTENCE:mutant phenotype:GO:0042275 error-free postreplication DNA repair [PMID:19079240]
experiment: EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:23142547|PMID:18757916]
experiment: EXISTENCE:mutant phenotype:GO:0070987 error-free translesion synthesis [PMID:18757916]
note: DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant
codon start: 1
product: DNA helicase RAD5
translation: MSHIEQEERKRFFNDDLDTSETSLNFKSENKESFLFANSHNDDDDDVVVSVSDTTEGEGDRSIVPVRREIEEEGQNQFITELLRIIPEMPKDLVMELNEKFGSQEEGLSLALSHYFDHNSGTSISKIPSSPNQLNTLSDTSNSTLSPSSFHPKRRRIYGFRNQTRLEDKVTWKRFIGALQVTGMATRPTVRPLKYGSQMKLKRSSEEISATKVYDSRGRKKASMASLVRIFDIQYDREIGRVSEDIAQILYPLLSSHEISFEVTLIFCDNKRLSIGDSFILQLDCFLTSLIFEERNDGESLMKRRRTEGGNKREKDNGNFGRTLTETDEELESRSKRLALLKLFDKLRLKPILDEQKALEKHKIELNSDPEIIDLDNDEICSNQVTEVHNNLRDTQHEEETMNLNQLKTFYKAAQSSESLKSLPETEPSRDVFKLELRNYQKQGLTWMLRREQEFAKAASDGEASETGANMINPLWKQFKWPNDMSWAAQNLQQDHVNVEDGIFFYANLHSGEFSLAKPILKTMIKGGILSDEMGLGKTVAAYSLVLSCPHDSDVVDKKLFDIENTAVSDNLPSTWQDNKKPYASKTTLIVVPMSLLTQWSNEFTKANNSPDMYHEVYYGGNVSSLKTLLTKTKTPPTVVLTTYGIVQNEWTKHSKGRMTDEDVNISSGLFSVNFYRIIIDEGHNIRNRTTVTSKAVMALQGKCKWVLTGTPIINRLDDLYSLVKFLELDPWRQINYWKTFVSTPFESKNYKQAFDVVNAILEPVLLRRTKQMKDKDGKPLVELPPKEVVIKRLPFSKSQDLLYKFLLDKAEVSVKSGIARGDLLKKYSTILVHILRLRQVCCHPGLIGSQDENDEDLSKNNKLVTEQTVELDSLMRVVSERFDNSFSKEELDAMIQRLKVKYPDNKSFQSLECSICTTEPMDLDKALFTECGHSFCEKCLFEYIEFQNSKNLGLKCPNCRNQIDACRLLALVQTNSNSKNLEFKPYSPASKSSKITALLKELQLLQDSSAGEQVVIFSQFSTYLDILEKELTHTFSKDVAKIYKFDGRLSLKERTSVLADFAVKDYSRQKILLLSLKAGGVGLNLTCASHAYMMDPWWSPSMEDQAIDRLHRIGQTNSVKVMRFIIQDSIEEKMLRIQEKKRTIGEAMDTDEDERRKRRIEEIQMLFE
SIO_010081: YLR032W
subclass of: SO_0000673
so part of: YLR032W
location: 204991..208500
location: region:204991-208500:1
so has part: feature:204991-208500:1:exon

NP_013132.1
type: Protein
SIO_000068: ncbiprotein

S000004022
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:204991-208500:1:exon

YLR033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSC58
locus tag: YLR033W
so part of: sequence
location: <208761..>210269
location: region:208761-210269:1
so has part: feature:208761-210269:1:exon
subclass of: SO_0000010

850720
type: Gene
SIO_000068: ncbigene

position:208761:1
position: 208761
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210269:1
position: 210269
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:208761-210269:1:exon

YLR033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSC58
locus tag: YLR033W
product: Rsc58p
transcript id: NM_001181920.1
SIO_010081: YLR033W
subclass of: SO_0000673
so part of: YLR033W
location: <208761..>210269
location: region:208761-210269:1
so has part: feature:208761-210269:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:208761-210269:1:exon

YLR033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSC58
locus tag: YLR033W
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12052880]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12052880]
note: Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
codon start: 1
product: Rsc58p
translation: MTESVGGNKLVDFLVNVQSILNAASVKCHVVDESFPAKFFEKNPDKIYESYCKFIKNRSNSEGLIRNEDKLVLTTINKRFENGEYEPIQGGFYKLYHDIKLVCTILIHFYPQGTRNYQLVDKFYKFSSELLLRECCRIGIALTQTNNIKSRSGKLLSGNEMDEYDDDDATELDKIISYDFIKISMNYTVPISQTYQIRTKDMDLFSSIISKSNLDKRPHELPNTNFKINNVLPQTDIENEAPRLGFVGANTSNIPDPTLPPTEMMTRFLHPNWYALPTTVWLKYGNYNSWAPSFNENGTVVDSTTRGLIWLERIGYMDLYEKNEKKVKQEELLNTNEEGINRKQNDENNKNVDGKSNGVQDDGGDNDNDATIASANSESTENKEQFIIKLQNLYNWTPSNYIGDDEIENFRNGTPDKLVSDSLLKLKRLRKERILNKVLKPTTEERELYFKVKRILKEVILAKKVSKVPINNVRAFPVLQTNYNGSIPVVRAQPGRKRKHKK
SIO_010081: YLR033W
subclass of: SO_0000673
so part of: YLR033W
location: 208761..210269
location: region:208761-210269:1
so has part: feature:208761-210269:1:exon

NP_013133.1
type: Protein
SIO_000068: ncbiprotein

S000004023
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:208761-210269:1:exon

YLR034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMF3
locus tag: YLR034C
so part of: sequence
location: complement(<210512..>211933)
location: region:210512-211933:-1
so has part: feature:210512-211933:-1:exon
subclass of: SO_0000010

850721
type: Gene
SIO_000068: ncbigene

position:210512:-1
position: 210512
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:211933:-1
position: 211933
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210512-211933:-1:exon

YLR034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMF3
locus tag: YLR034C
product: putative divalent metal ion transporter SMF3
transcript id: NM_001181921.2
SIO_010081: YLR034C
subclass of: SO_0000673
so part of: YLR034C
location: complement(<210512..>211933)
location: region:210512-211933:-1
so has part: feature:210512-211933:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210512-211933:-1:exon

YLR034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMF3
locus tag: YLR034C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11027260|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006826 iron ion transport [PMID:17681937]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:11027260]
note: Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative divalent metal ion transporter SMF3
translation: MRSYMQILQKFAKFIGPGILVSVAYMDPGNYATSVSGGAQYKYTLLFSIFISNIFAVLLQCLCVKLGTITGYDLAENCRHNLPKKLNYTLYLFAEVAIIATDLAEVVGTAIALQILFKIPLTWGVLLTVLDVLVILMFYTPNGQSLKKVRVFEFGVGILVIGTCICFVLELFKVSIPDKAELFKGFLPSNIIFKEQQALYISLGILGATVMPHSLYLGSSIVKPRLHDYDLKKYGKVNARPSLSAIKYTLNYAYAELIISLFLIATFVNSAILIVAGATLSGQPEAEDADLLSIYKLLVHYISPAAGLIFALAMLCSGQSAGIICTLAGQIVSEGFLQWSLPPWATRLCTRLIAIVPCLFVTLTMGEKGISDILNFSQVVLSLILPIVSAPLIYFTANRKLMVVHDENGVVRAPADVNAIADETTPLNSKHSKIVDFTNSRLLTYTSVFVWALIGSLNCYLVISYLLGADIHF
SIO_010081: YLR034C
subclass of: SO_0000673
so part of: YLR034C
location: complement(210512..211933)
location: region:210512-211933:-1
so has part: feature:210512-211933:-1:exon

NP_013134.1
type: Protein
SIO_000068: ncbiprotein

S000004024
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210512-211933:-1:exon

YLR035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MLH2
locus tag: YLR035C
so part of: sequence
location: complement(<212369..>214456)
location: region:212369-214456:-1
so has part: feature:212369-214456:-1:exon
subclass of: SO_0000010

850722
type: Gene
SIO_000068: ncbigene

position:212369:-1
position: 212369
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214456:-1
position: 214456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212369-214456:-1:exon

YLR035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MLH2
locus tag: YLR035C
product: mismatch repair protein MLH2
transcript id: NM_001181922.1
SIO_010081: YLR035C
subclass of: SO_0000673
so part of: YLR035C
location: complement(<212369..>214456)
location: region:212369-214456:-1
so has part: feature:212369-214456:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212369-214456:-1:exon

YLR035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MLH2
locus tag: YLR035C
experiment: EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:28051769]
experiment: EXISTENCE:direct assay:GO:0000405 bubble DNA binding [PMID:28051769]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:10679328]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15467363]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10570173]
experiment: EXISTENCE:physical interaction:GO:0032390 MutLbeta complex [PMID:10570173]
note: Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex
codon start: 1
product: mismatch repair protein MLH2
translation: MTIHQLSPESQWKIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVDIIDRPSMCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLVDSKGGITNGKRYKVSCPVGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLIHRNIRFYFSLVSLQKNGAIERKQMQETLDPKISRARSLSLLARLKKPVPLNFIVEENFVIDEKINLDLILPRMVPESDVINIKRRFKFLSVNERALSLNLETGKTISKLLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIENKLKLLLEERIGIETNMLGDKHVQPSINEKTSPALVIPTPDAENEISKGCGAVSGKDKTDIPQKNSDLIVPTFYDEANLENTTIVAATPSPTKFSEDKALDEQTQLTISSYRSSSSGSMASEDSTNWRHNFQQELSENSEVAGAGSSTLPSSLTYNYIETIPENEDLELSKDASISNPFMITKIRNVNKKLSENLLEAKRTSCGDANKRGMPNERQLSNTEKKELIKLQQTYGKRNNTVDMTIPRNSKKKVTDNYIKKASCMHKTRPKLMHFSEYTNNYVYTLKNEKIVKHDSDNFAKETLWLRSRDDATSPSSSLLQALRAHVKKPGHIEATTNEWCLFTPDSP
SIO_010081: YLR035C
subclass of: SO_0000673
so part of: YLR035C
location: complement(212369..214456)
location: region:212369-214456:-1
so has part: feature:212369-214456:-1:exon

NP_013135.1
type: Protein
SIO_000068: ncbiprotein

S000004025
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212369-214456:-1:exon

YNCL0004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0004C
so part of: sequence
location: complement(214883..214955)
location: region:214883-214955:-1
so has part: feature:214883-214955:-1:exon
subclass of: SO_0000663

850723
type: Gene
SIO_000068: ncbigene

position:214883:-1
position: 214883
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:214955:-1
position: 214955
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214883-214955:-1:exon

YNCL0004C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0004C
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 5 nuclear tRNA genes containing the tDNA-anticodon TGC (mature tRNA may be UGC or may contain modified bases), decodes GCA and probably GCG codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCL0004C
subclass of: SO_0000673
so part of: YNCL0004C
location: complement(214883..214955)
location: region:214883-214955:-1
so has part: feature:214883-214955:-1:exon

S000006524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214883-214955:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(215080..215417)
location: region:215080-215417:-1
so has part: feature:215080-215417:-1:region

S000007065
type: SGD
SIO_000068: sgd

position:215080:-1
position: 215080
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:215417:-1
position: 215417
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215080-215417:-1:region

YLR035C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR035C-A
so part of: sequence
location: complement(<215440..>218907)
location: region:215440-218907:-1
so has part: feature:215440-218907:-1:exon
subclass of: SO_0000010

850724
type: Gene
SIO_000068: ncbigene

position:215440:-1
position: 215440
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218907:-1
position: 218907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215440-218907:-1:exon

YLR035C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR035C-A
product: gag-pol fusion protein
transcript id: NM_001184318.1
SIO_010081: YLR035C-A
subclass of: SO_0000673
so part of: YLR035C-A
location: complement(<215440..>218907)
location: region:215440-218907:-1
so has part: feature:215440-218907:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:215440-218907:-1:exon

YLR035C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR035C-A
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
note: Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon
codon start: 1
product: gag-pol fusion protein
translation: MLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRGGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLASDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YLR035C-A
subclass of: SO_0000673
so part of: YLR035C-A
location: complement(215440..218907)
location: region:215440-218907:-1
so has part: feature:215440-218907:-1:exon

NP_013136.1
type: Protein
SIO_000068: ncbiprotein

S000007225
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:215440-218907:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(220668..221005)
location: region:220668-221005:-1
so has part: feature:220668-221005:-1:region

S000007066
type: SGD
SIO_000068: sgd

position:220668:-1
position: 220668
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:221005:-1
position: 221005
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220668-221005:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 221006..221266
location: region:221006-221266:1
so has part: feature:221006-221266:1:region

S000007083
type: SGD
SIO_000068: sgd

position:221006:1
position: 221006
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:221266:1
position: 221266
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221006-221266:1:region

YLR036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR036C
so part of: sequence
location: complement(<221521..>222132)
location: region:221521-222132:-1
so has part: feature:221521-222132:-1:exon
subclass of: SO_0000010

850725
type: Gene
SIO_000068: ncbigene

position:221521:-1
position: 221521
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222132:-1
position: 222132
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221521-222132:-1:exon

YLR036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR036C
product: uncharacterized protein
transcript id: NM_001181923.1
SIO_010081: YLR036C
subclass of: SO_0000673
so part of: YLR036C
location: complement(<221521..>222132)
location: region:221521-222132:-1
so has part: feature:221521-222132:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221521-222132:-1:exon

YLR036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR036C
note: Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
codon start: 1
product: uncharacterized protein
translation: MKEAELSATESQDEIPKSNSLLIIEKLTKAVCSLYFINCFMVPSVDNLIEKYPKAIIIKIIDMILGAVTISLVIIVFFLYRKNGHFKNENKTKPKRCSKVVCPSCAARKKYPKWFQLKYLLLVSMTAFSFYFCTKIRFFFKTDQTINLHRLSQLFRLQLGWICTTALLFYFYDALILHSGFIEGYRCVNGKGAMSEGKTGQLN
SIO_010081: YLR036C
subclass of: SO_0000673
so part of: YLR036C
location: complement(221521..222132)
location: region:221521-222132:-1
so has part: feature:221521-222132:-1:exon

NP_013137.1
type: Protein
SIO_000068: ncbiprotein

S000004026
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221521-222132:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1210; Autonomously replicating sequence
so part of: sequence
location: 222220..222676
location: region:222220-222676:1
so has part: feature:222220-222676:1:region

S000178132
type: SGD
SIO_000068: sgd

position:222220:1
position: 222220
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:222676:1
position: 222676
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222220-222676:1:region

YLR037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DAN2
gene: PAU23
locus tag: YLR037C
gene synonym: DAN2
so part of: sequence
location: complement(<222685..>223059)
location: region:222685-223059:-1
so has part: feature:222685-223059:-1:exon
subclass of: SO_0000010

850726
type: Gene
SIO_000068: ncbigene

position:222685:-1
position: 222685
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:223059:-1
position: 223059
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222685-223059:-1:exon

YLR037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DAN2
gene: PAU23
locus tag: YLR037C
gene synonym: DAN2
product: seripauperin PAU23
transcript id: NM_001181924.1
SIO_010081: YLR037C
subclass of: SO_0000673
so part of: YLR037C
location: complement(<222685..>223059)
location: region:222685-223059:-1
so has part: feature:222685-223059:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:222685-223059:-1:exon

YLR037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DAN2
gene: PAU23
locus tag: YLR037C
gene synonym: DAN2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
codon start: 1
product: seripauperin PAU23
translation: MVKLTSIVAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAEYYMFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPADQVTRVITGVPWYSTRLRPAISSALSKDGIYTAVPN
SIO_010081: YLR037C
subclass of: SO_0000673
so part of: YLR037C
location: complement(222685..223059)
location: region:222685-223059:-1
so has part: feature:222685-223059:-1:exon

NP_013138.1
type: Protein
SIO_000068: ncbiprotein

S000004027
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:222685-223059:-1:exon

YLR038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX12
locus tag: YLR038C
so part of: sequence
location: complement(<224921..>225172)
location: region:224921-225172:-1
so has part: feature:224921-225172:-1:exon
subclass of: SO_0000010

850727
type: Gene
SIO_000068: ncbigene

position:224921:-1
position: 224921
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225172:-1
position: 225172
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224921-225172:-1:exon

YLR038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX12
locus tag: YLR038C
product: cytochrome c oxidase subunit VIb
transcript id: NM_001181925.1
SIO_010081: YLR038C
subclass of: SO_0000673
so part of: YLR038C
location: complement(<224921..>225172)
location: region:224921-225172:-1
so has part: feature:224921-225172:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224921-225172:-1:exon

YLR038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX12
locus tag: YLR038C
experiment: EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:1331058]
note: Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly and activity of cytochrome c oxidase; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
codon start: 1
product: cytochrome c oxidase subunit VIb
translation: MADQENSPLHTVGFDARFPQQNQTKHCWQSYVDYHKCVNMKGEDFAPCKVFWKTYNALCPLDWIEKWDDQREKGIFAGDINSD
SIO_010081: YLR038C
subclass of: SO_0000673
so part of: YLR038C
location: complement(224921..225172)
location: region:224921-225172:-1
so has part: feature:224921-225172:-1:exon

NP_013139.1
type: Protein
SIO_000068: ncbiprotein

S000004028
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224921-225172:-1:exon

YLR039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIC1
locus tag: YLR039C
so part of: sequence
location: complement(<225426..>228596)
location: region:225426-228596:-1
so has part: feature:225426-228596:-1:exon
subclass of: SO_0000010

850728
type: Gene
SIO_000068: ncbigene

position:225426:-1
position: 225426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228596:-1
position: 228596
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:225426-228596:-1:exon

YLR039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIC1
locus tag: YLR039C
product: Ric1p
transcript id: NM_001181926.1
SIO_010081: YLR039C
subclass of: SO_0000673
so part of: YLR039C
location: complement(<225426..>228596)
location: region:225426-228596:-1
so has part: feature:225426-228596:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225426-228596:-1:exon

YLR039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIC1
locus tag: YLR039C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10990452]
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:24924636]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:10990452]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]
experiment: EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]
experiment: EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:11160819]
experiment: EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]
experiment: EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]
experiment: EXISTENCE:physical interaction:GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex [PMID:10990452]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]
note: Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
codon start: 1
product: Ric1p
translation: MFIKQSEKNTPKCLYKKKGKVRVLLTGSCKKLNTWKMHLWPVSPPQLLRIPPRNAELGEGTKIDDCNILQSMTLPQANVLIMLTPTRVLIYNFKPMALVASHERTMASLKEFGDNRSMKRSAPYNDIIEGLISKKDSQYLLWHQGKLIFYVMTDKNFLLTYQILKNCTNEIIFKEYGIPVIEPLLMSEEEANSAEYDYNNDDDTLTVFDKNSSSRIIQNGFGITKEKGFLHFLSNQENIDELPVKKLELRLKVVLKFDYEIIDMIGIKTFSKVGDGRYEEVLIVLFPHGLQILTISDFKVSKSSLVEVKKGSKTIVCNKQLMVLSHDSVEKQTIVSIIDIEKQAVEAIPLTDTPDELLTCLEVNGYLVVVYKEKIICFDTRIKKVSHSWKPPFVIKLCDKINDKILLLVSEDSVNIHFYTEFGNLLFATYFDEDDYNGDNNNDNSKDKNEKKAAEYKISDFVCLDKSLITVSHSGKYQVWKLWEEIKQTQFDFRNPKCYVLTNTNNDVIIYSPVTSSSINNDNLQVIKLPTKTFNNHIAFVKINSSLRLFATYVSNKNILLIHNLETNMWSSFADQNVLDLHWLGDNYLVCHMKNDDGSTNLKCLQIPLQEANPDVELSDYVMWEYNVPENTIVFSLHVNTLSRYKLLKMKSKNHNASEKQPDALLKTAEIILVTDTQTIVFDVISTVHPCGLNIIKKFYQYLKINIPIDVLPNKIEWIINMKEGLLFFADRKFIKLGKVDGGGWQTLTLLDNIEKIIDVIRDEIFVVQGHNYVVYSLEDLWDDKKPLVSIPIEEDLYPISTTPETATTHTLHCIFNARFSKLVVKHQIYLDQLILAKLEDNTDLEDISHNYRFLKPYKFALEKILSTKILRSDSLDDILKLIKMYDNTDPEHNISPPTHSGMLEIISNCLRKIETKYWNHLFTNLKMTPRDLLALCIEENEAKMLGVLLLVFLNYDEKDLGDDLHFKKSDLGTEESKALNDNSTKKSEKSVTNLLKDEELMLKVLELLVTSAANATDPIKATDSWDMCFQLIRLLKELDRENNTQLVQKALERFK
SIO_010081: YLR039C
subclass of: SO_0000673
so part of: YLR039C
location: complement(225426..228596)
location: region:225426-228596:-1
so has part: feature:225426-228596:-1:exon

NP_013140.1
type: Protein
SIO_000068: ncbiprotein

S000004029
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225426-228596:-1:exon

YLR040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AFB1
locus tag: YLR040C
so part of: sequence
location: complement(<228908..>229582)
location: region:228908-229582:-1
so has part: feature:228908-229582:-1:exon
subclass of: SO_0000010

850730
type: Gene
SIO_000068: ncbigene

position:228908:-1
position: 228908
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229582:-1
position: 229582
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228908-229582:-1:exon

YLR040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AFB1
locus tag: YLR040C
product: Afb1p
transcript id: NM_001181927.1
SIO_010081: YLR040C
subclass of: SO_0000673
so part of: YLR040C
location: complement(<228908..>229582)
location: region:228908-229582:-1
so has part: feature:228908-229582:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228908-229582:-1:exon

YLR040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AFB1
locus tag: YLR040C
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:24121774]
experiment: EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:24121774]
note: MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W
codon start: 1
product: Afb1p
translation: MIFAPSFSLIKNILLVSFLISHSFAAKTLTSSSNDDTLARSAAADADMAFFMEFLNDFDTAFPQYTSYMMQNHLTLPQPVADYYYHMVDLASTADLQSDIAQSFPFTQFQTFITAFPWYTSLLNKASATTIYLPQHFITGETEATMTNSSYASQKNSVSNSVPFSTANAGQSMISMANEENSTTALISASNSSSTSRTSQSQNGAHAKSLYFPMALFGIFAVAL
SIO_010081: YLR040C
subclass of: SO_0000673
so part of: YLR040C
location: complement(228908..229582)
location: region:228908-229582:-1
so has part: feature:228908-229582:-1:exon

NP_013141.1
type: Protein
SIO_000068: ncbiprotein

S000004030
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228908-229582:-1:exon

YLR042C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NFG1
locus tag: YLR042C
so part of: sequence
location: complement(<229966..>230451)
location: region:229966-230451:-1
so has part: feature:229966-230451:-1:exon
subclass of: SO_0000010

850731
type: Gene
SIO_000068: ncbigene

position:229966:-1
position: 229966
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:230451:-1
position: 230451
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229966-230451:-1:exon

YLR042C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NFG1
locus tag: YLR042C
product: Nfg1p
transcript id: NM_001181929.1
SIO_010081: YLR042C
subclass of: SO_0000673
so part of: YLR042C
location: complement(<229966..>230451)
location: region:229966-230451:-1
so has part: feature:229966-230451:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229966-230451:-1:exon

YLR042C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NFG1
locus tag: YLR042C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0060258 negative regulation of filamentous growth [PMID:32665277]
note: Negative regulator of the filamentous growth pathway; inhibits invasive growth by dampening the activity of the filamentous MAPK pathway; localizes to the cell wall and to the vacuole and cell periphery in HTP studies; deletion improves xylose fermentation in industrially engineered strains; nonessential gene
codon start: 1
product: Nfg1p
translation: MKISQFGSLAFAPIVLLQLFIVQAQLLTDSNAQDLNTALGQKVQYTFLDTGNSNDQLLHLPSTTSSSIITGSLAAANFTGSSSSSSIPKVTSSVITSINYQSSNSTVVTQFTPLPSSSRNETKSSQTTNTISSSTSTGGVGSVKPCLYFVLMLETIAYLFS
SIO_010081: YLR042C
subclass of: SO_0000673
so part of: YLR042C
location: complement(229966..230451)
location: region:229966-230451:-1
so has part: feature:229966-230451:-1:exon

NP_013143.1
type: Protein
SIO_000068: ncbiprotein

S000004032
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229966-230451:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1211; Autonomously Replicating Sequence
so part of: sequence
location: 231179..231421
location: region:231179-231421:1
so has part: feature:231179-231421:1:region

S000118471
type: SGD
SIO_000068: sgd

position:231179:1
position: 231179
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:231421:1
position: 231421
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231179-231421:1:region

YLR043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LMA1
gene: TRX1
locus tag: YLR043C
gene synonym: LMA1
so part of: sequence
location: complement(<231702..>232013)
location: region:231702-232013:-1
so has part: feature:231702-232013:-1:exon
subclass of: SO_0000010

850732
type: Gene
SIO_000068: ncbigene

position:231702:-1
position: 231702
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:232013:-1
position: 232013
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231702-232013:-1:exon

YLR043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LMA1
gene: TRX1
locus tag: YLR043C
gene synonym: LMA1
product: thioredoxin TRX1
transcript id: NM_001181930.1
SIO_010081: YLR043C
subclass of: SO_0000673
so part of: YLR043C
location: complement(<231702..>232013)
location: region:231702-232013:-1
so has part: feature:231702-232013:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:231702-232013:-1:exon

YLR043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LMA1
gene: TRX1
locus tag: YLR043C
gene synonym: LMA1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8603912|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9813082]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9813082]
experiment: EXISTENCE:direct assay:GO:0015036 disulfide oxidoreductase activity [PMID:19362171]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9657146]
experiment: EXISTENCE:direct assay:GO:0080058 protein deglutathionylation [PMID:20074363]
experiment: EXISTENCE:genetic interaction:GO:0045454 cell redox homeostasis [PMID:22561702]
experiment: EXISTENCE:genetic interaction:GO:0080058 protein deglutathionylation [PMID:20074363]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:8603912|PMID:9015301]
experiment: EXISTENCE:physical interaction:GO:0005829 cytosol [PMID:9159115]
note: Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress
codon start: 1
product: thioredoxin TRX1
translation: MVTQFKTASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAKVVGANPAAIKQAIAANA
SIO_010081: YLR043C
subclass of: SO_0000673
so part of: YLR043C
location: complement(231702..232013)
location: region:231702-232013:-1
so has part: feature:231702-232013:-1:exon

NP_013144.1
type: Protein
SIO_000068: ncbiprotein

S000004033
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:231702-232013:-1:exon

YLR044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDC1
locus tag: YLR044C
so part of: sequence
location: complement(<232390..>234081)
location: region:232390-234081:-1
so has part: feature:232390-234081:-1:exon
subclass of: SO_0000010

850733
type: Gene
SIO_000068: ncbigene

position:232390:-1
position: 232390
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:234081:-1
position: 234081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232390-234081:-1:exon

YLR044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDC1
locus tag: YLR044C
product: indolepyruvate decarboxylase 1
transcript id: NM_001181931.1
SIO_010081: YLR044C
subclass of: SO_0000673
so part of: YLR044C
location: complement(<232390..>234081)
location: region:232390-234081:-1
so has part: feature:232390-234081:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232390-234081:-1:exon

YLR044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDC1
locus tag: YLR044C
EC number: 4.1.1.43
EC number: 4.1.1.72
EC number: 4.1.1.74
experiment: EXISTENCE:direct assay:GO:0004737 pyruvate decarboxylase activity [PMID:23423327|PMID:2404950]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16850348|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2665820]
experiment: EXISTENCE:direct assay:GO:0006090 pyruvate metabolic process [PMID:2404950]
experiment: EXISTENCE:direct assay:GO:0019655 glycolytic fermentation to ethanol [PMID:2404950]
experiment: EXISTENCE:direct assay:GO:0046809 replication compartment [PMID:31648290]
experiment: EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
experiment: EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]
experiment: EXISTENCE:genetic interaction:GO:0006569 tryptophan catabolic process [PMID:12499363]
experiment: EXISTENCE:mutant phenotype:GO:0045069 regulation of viral genome replication [PMID:31648290]
experiment: EXISTENCE:mutant phenotype:GO:0047433 branched-chain-2-oxoacid decarboxylase activity [PMID:9546164]
note: Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation
codon start: 1
product: indolepyruvate decarboxylase 1
translation: MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQAKLTAATNAKQ
SIO_010081: YLR044C
subclass of: SO_0000673
so part of: YLR044C
location: complement(232390..234081)
location: region:232390-234081:-1
so has part: feature:232390-234081:-1:exon

NP_013145.1
type: Protein
SIO_000068: ncbiprotein

S000004034
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232390-234081:-1:exon

YLR045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STU2
locus tag: YLR045C
so part of: sequence
location: complement(<235037..>237703)
location: region:235037-237703:-1
so has part: feature:235037-237703:-1:exon
subclass of: SO_0000010

850734
type: Gene
SIO_000068: ncbigene

position:235037:-1
position: 235037
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237703:-1
position: 237703
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:235037-237703:-1:exon

YLR045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STU2
locus tag: YLR045C
product: Stu2p
transcript id: NM_001181932.1
SIO_010081: YLR045C
subclass of: SO_0000673
so part of: YLR045C
location: complement(<235037..>237703)
location: region:235037-237703:-1
so has part: feature:235037-237703:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:235037-237703:-1:exon

YLR045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STU2
locus tag: YLR045C
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347|PMID:11553724]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:9606209]
experiment: EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0046785 microtubule polymerization [PMID:25172511]
experiment: EXISTENCE:direct assay:GO:0061863 microtubule plus end polymerase [PMID:25172511]
experiment: EXISTENCE:genetic interaction:GO:0007052 mitotic spindle organization [PMID:11756468]
experiment: EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]
experiment: EXISTENCE:mutant phenotype:GO:0008017 microtubule binding [PMID:11553724]
note: Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of mitotic spindle during anaphase, as well as for spindle orientation and metaphase chromosome alignment; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member
codon start: 1
product: Stu2p
translation: MSGEEEVDYTTLPLEERLTYKLWKARLEAYKELNQLFRNSVGDISRDDNIQIYWRDPTLFAQYITDSNVVAQEQAIVALNSLIDAFASSSLKNAHNITLISTWTPLLVEKGLTSSRATTKTQSMSCILSLCGLDTSITQSVELVIPFFEKKLPKLIAAAANCVYELMAAFGLTNVNVQTFLPELLKHVPQLAGHGDRNVRSQTMNLIVEIYKVTGNNSDLLEEILFKKLKPIQVKDLHKLFAKVGDEPSSSKMLFEWEKRELEKKRSQEEEARKRKSILSNDEGEYQIDKDGDTLMGMETDMPPSKQQSGVQIDTFSMLPEETILDKLPKDFQERITSSKWKDRVEALEEFWDSVLSQTKKLKSTSQNYSNLLGIYGHIIQKDANIQAVALAAQSVELICDKLKTPGFSKDYVSLVFTPLLDRTKEKKPSVIEAIRKALLTICKYYDPLASSGRNEDMLKDILEHMKHKTPQIRMECTQLFNASMKEEKDGYSTLQRYLKDEVVPIVIQIVNDTQPAIRTIGFESFAILIKIFGMNTFVKTLEHLDNLKRKKIEETVKTLPNFSIASGSTHSTIETNKQTGPMENKFLLKKSSVLPSKRVASSPLRNDNKSKVNPIGSVASASKPSMVAANNKSRVLLTSKSLATPKNVVANSTDKNEKLIEEYKYRLQKLQNDEMIWTKERQSLLEKMNNTENYKIEMIKENEMLREQLKEAQSKLNEKNIQLRSKEIDVNKLSDRVLSLENELRNMEIELDRNKKRNDTNLQSMGTISSYSIPSSTVSSNYGVKSLSSALPFKEEEDVRRKEDVNYERRSSESIGDLPHRVNSLNIRPYRKNGTGVSSVSDDLDIDFNDSFASEESYKRAAAVTSTLKARIEKMKAKSRREGTTRT
SIO_010081: YLR045C
subclass of: SO_0000673
so part of: YLR045C
location: complement(235037..237703)
location: region:235037-237703:-1
so has part: feature:235037-237703:-1:exon

NP_013146.1
type: Protein
SIO_000068: ncbiprotein

S000004035
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:235037-237703:-1:exon

YLR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR046C
so part of: sequence
location: complement(<238001..>238813)
location: region:238001-238813:-1
so has part: feature:238001-238813:-1:exon
subclass of: SO_0000010

850735
type: Gene
SIO_000068: ncbigene

position:238001:-1
position: 238001
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238813:-1
position: 238813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:238001-238813:-1:exon

YLR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR046C
product: uncharacterized protein
transcript id: NM_001181933.1
SIO_010081: YLR046C
subclass of: SO_0000673
so part of: YLR046C
location: complement(<238001..>238813)
location: region:238001-238813:-1
so has part: feature:238001-238813:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:238001-238813:-1:exon

YLR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR046C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MATHTSKRRIHRWENNELSEENSTIIYFPARGLMWTHFPFVLGICLEFVGYVLKIVFINSPSISTFIAQSVLLLIAPSLYALSIFMLFSKMARLILMEAYMLIPAKFSTVSFVVADMIGRVLQAVGGGLLSSWNSRNTGRILIIVGLFIQIFCYTFLTFSQLFLHYKMKATPSKIVRDSNEWFQYNFILLAGILLVNGRTIVRVVQFLMGLQSYIGQHEWCLYVFDTVLMFLLPLIFLATFRARNLFKLQDKSVNIQLNKLLDKESVSED
SIO_010081: YLR046C
subclass of: SO_0000673
so part of: YLR046C
location: complement(238001..238813)
location: region:238001-238813:-1
so has part: feature:238001-238813:-1:exon

NP_013147.1
type: Protein
SIO_000068: ncbiprotein

S000004036
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:238001-238813:-1:exon

YLR047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRE8
locus tag: YLR047C
so part of: sequence
location: complement(<239347..>241407)
location: region:239347-241407:-1
so has part: feature:239347-241407:-1:exon
subclass of: SO_0000010

850736
type: Gene
SIO_000068: ncbigene

position:239347:-1
position: 239347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241407:-1
position: 241407
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:239347-241407:-1:exon

YLR047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRE8
locus tag: YLR047C
product: putative ferric-chelate reductase
transcript id: NM_001181934.1
SIO_010081: YLR047C
subclass of: SO_0000673
so part of: YLR047C
location: complement(<239347..>241407)
location: region:239347-241407:-1
so has part: feature:239347-241407:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239347-241407:-1:exon

YLR047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRE8
locus tag: YLR047C
EC number: 1.16.1.7
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006875 cellular metal ion homeostasis [PMID:14534306]
experiment: EXISTENCE:mutant phenotype:GO:0016722 oxidoreductase activity, acting on metal ions [PMID:14534306]
note: Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
codon start: 1
product: putative ferric-chelate reductase
translation: MNLKSIVSWFKEHLPSFDVDVDKHFRTLRVRKYSQICLLISFIIICVIIPLMNYLLLTDKFFKICHHLKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMGRISVALMPPLLFLTLRPSPLPHTLYLALLPLHKWISRIVVLESILHTWFYLYYMYINDTLYVKMRKLPNIYGVIALGLFLLIAITSVRYARRWSYRVFYYVHYVSTWLILVFLHYHARPGISYYTTLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLEFPLTDLPKKPILPGGHLRINIYHRNFLRRFFSHLIPFQHPFTIASIPSDNLVRLIIRNGHFPLRTNEKYYITGAFEPELSFISKPTVPFNITTKSSKNPFRNNSSALINSPLNFLIKAQRVFMCVGGSGISFGLPLLRILNFNGVNVRLLWVSRDYKDLEVLNHFKNNFEGMEIYISGTEGNEQDIEIDYIDYHDCAADINDEVRSISSSGRVSELGDNSMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDINADDEIDFTYAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKIRIPAGVKVFFGRPTLGDKDYEWCLQTECDAETDSIQCCRWANQGRDHAEYLSQVWVLAAGPRGLIESTKRWATDGGLHFHGESFAL
SIO_010081: YLR047C
subclass of: SO_0000673
so part of: YLR047C
location: complement(239347..241407)
location: region:239347-241407:-1
so has part: feature:239347-241407:-1:exon

NP_013148.1
type: Protein
SIO_000068: ncbiprotein

S000004037
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239347-241407:-1:exon

YLR048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAB1B
alternative label: YST2
gene: RPS0B
locus tag: YLR048W
gene synonym: NAB1B; YST2
so part of: sequence
location: <242232..>243349
location: region:242232-243349:1
so has part: feature:242232-243349:1:exon
subclass of: SO_0000010

850737
type: Gene
SIO_000068: ncbigene

position:242232:1
position: 242232
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:243349:1
position: 243349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:242232-243349:1:exon

YLR048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAB1B
alternative label: YST2
gene: RPS0B
locus tag: YLR048W
gene synonym: NAB1B; YST2
product: ribosomal 40S subunit protein S0B
transcript id: NM_001181935.1
SIO_010081: YLR048W
subclass of: SO_0000673
so part of: YLR048W
location: join(<242232..242321,242681..>243349)
location: region:242232-243349:1
so has part: feature:242232-242321:1:exon
so has part: feature:242681-243349:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:242232-242321:1:exon

position:242321:1
position: 242321
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:242681-243349:1:exon

position:242681:1
position: 242681
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAB1B
alternative label: YST2
gene: RPS0B
locus tag: YLR048W
gene synonym: NAB1B; YST2
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:8626693]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8626693]
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8626693]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]
experiment: EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:8626693]
note: Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
codon start: 1
product: ribosomal 40S subunit protein S0B
translation: MSLPATFDLTPEDAQLLLAANTHLGARNVQVHQEPYVFNARPDGVHVINVGKTWEKLVLAARIIAAIPNPEDVVAISSRTYGQRAVLKFAAHTGATPIAGRFTPGSFTNYITRSFKEPRLVIVTDPRLDAQAIKEASYVNIPVIALTDLDSPSEFVDVAIPCNNRGKHSIGLIWYLLAREVLRLRGALVDRTQPWSIMPDLYFYRNPEEVEQVAEEAAAAEEGEEEEVKEEVTEGQAEATEWAEENADNVEW
SIO_010081: YLR048W
subclass of: SO_0000673
so part of: YLR048W
location: join(242232..242321,242681..243349)
location: region:242232-243349:1
so has part: feature:242232-242321:1:exon
so has part: feature:242681-243349:1:exon

NP_013149.1
type: Protein
SIO_000068: ncbiprotein

S000004038
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:242232-242321:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:242681-243349:1:exon

YLR049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MLO50
locus tag: YLR049C
so part of: sequence
location: complement(<243886..>245172)
location: region:243886-245172:-1
so has part: feature:243886-245172:-1:exon
subclass of: SO_0000010

850738
type: Gene
SIO_000068: ncbigene

position:243886:-1
position: 243886
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245172:-1
position: 245172
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243886-245172:-1:exon

YLR049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MLO50
locus tag: YLR049C
product: Mlo50p
transcript id: NM_001181936.1
SIO_010081: YLR049C
subclass of: SO_0000673
so part of: YLR049C
location: complement(<243886..>245172)
location: region:243886-245172:-1
so has part: feature:243886-245172:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243886-245172:-1:exon

YLR049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MLO50
locus tag: YLR049C
note: Mitochondrial hypothetical protein
codon start: 1
product: Mlo50p
translation: MVNNIMHEYVPPSQRLFHSRHRITRNDLKEEALHSGTTDWTTILDTTIDKDTNLISYAVPIIDNFAIPRANSQGSPVAPSPNHRSTMYSSSSSSASSVFSDGLFTPNNNRNSSGSSSLVIRPQKNLSVDSLIQENKRKINSEKESLSLIANNNDETLCTHTDPSIQNLIKSETKRNILNLKFQNRNLFRRELKLEKFWSNLRSCHTSGDETDLLLVISKHNLYWFGIPNDFRLPIYKRCLYHYSELDEAGFFSQYANNSLYLAIRKCCNNEEQETLSRSIFINLTKNVTWLNSRFDDNKDNKNSYTVTEGKFYQDFPNLYYHLKDKLKLNVIMDFIKPVIRNFMTNALNKHKLDGIGLELLDILIVTTYYGPNKINAFLMDTFILNLLKQCHYKFFVSNISELVIQISKIDCDLVILLEDLRSRIDLD
SIO_010081: YLR049C
subclass of: SO_0000673
so part of: YLR049C
location: complement(243886..245172)
location: region:243886-245172:-1
so has part: feature:243886-245172:-1:exon

NP_013150.1
type: Protein
SIO_000068: ncbiprotein

S000004039
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243886-245172:-1:exon

YLR050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMA19
locus tag: YLR050C
so part of: sequence
location: complement(<245587..>246072)
location: region:245587-246072:-1
so has part: feature:245587-246072:-1:exon
subclass of: SO_0000010

850739
type: Gene
SIO_000068: ncbigene

position:245587:-1
position: 245587
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246072:-1
position: 246072
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245587-246072:-1:exon

YLR050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMA19
locus tag: YLR050C
product: Ema19p
transcript id: NM_001181937.1
SIO_010081: YLR050C
subclass of: SO_0000673
so part of: YLR050C
location: complement(<245587..>246072)
location: region:245587-246072:-1
so has part: feature:245587-246072:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245587-246072:-1:exon

YLR050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMA19
locus tag: YLR050C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:30213914|PMID:33596095]
experiment: EXISTENCE:mutant phenotype:GO:0032594 protein transport within lipid bilayer [PMID:30213914]
note: Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97
codon start: 1
product: Ema19p
translation: MKLGHREQQFYLWYFIVHIPITIFIDSSVVIPAKWQLGIAQKVVSDHIAKQHDFLLSEKPEWLYWFVVLELVLQLPLFVYFVNKFWNSSELQVNTNSRLKKWLRIYGWNASLTTLICIVVIFKRGYIPYDVLKTSLSMTQKCQLASVYLPTFLIPLRLCFV
SIO_010081: YLR050C
subclass of: SO_0000673
so part of: YLR050C
location: complement(245587..246072)
location: region:245587-246072:-1
so has part: feature:245587-246072:-1:exon

NP_013151.1
type: Protein
SIO_000068: ncbiprotein

S000004040
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245587-246072:-1:exon

YLR051C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FCF2
locus tag: YLR051C
so part of: sequence
location: complement(<246324..>246977)
location: region:246324-246977:-1
so has part: feature:246324-246977:-1:exon
subclass of: SO_0000010

850740
type: Gene
SIO_000068: ncbigene

position:246324:-1
position: 246324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246977:-1
position: 246977
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246324-246977:-1:exon

YLR051C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FCF2
locus tag: YLR051C
product: Fcf2p
transcript id: NM_001181938.1
SIO_010081: YLR051C
subclass of: SO_0000673
so part of: YLR051C
location: complement(<246324..>246977)
location: region:246324-246977:-1
so has part: feature:246324-246977:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246324-246977:-1:exon

YLR051C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FCF2
locus tag: YLR051C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:14690591]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]
note: Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene
codon start: 1
product: Fcf2p
translation: MDQSVEDLFGALRDASASLEVKNSAKEQVSLQQEDVLQIGNNDDEVEIESKFQEIETNLKKLPKLETGFDALANKKKKKNVLPSVETEDKRKPNKSDKNDNDWFTLPKPDDNMRREVQRDLLLIKHRAALDPKRHYKKQRWEVPERFAIGTIIEDKSEFYSSRMNRKERKSTILETLMGDEASNKYFKRKYNEIQEKSTSGRKAHYKKMKEMRKKRR
SIO_010081: YLR051C
subclass of: SO_0000673
so part of: YLR051C
location: complement(246324..246977)
location: region:246324-246977:-1
so has part: feature:246324-246977:-1:exon

NP_013152.1
type: Protein
SIO_000068: ncbiprotein

S000004041
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246324-246977:-1:exon

YLR052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IES3
locus tag: YLR052W
so part of: sequence
location: <247201..>247953
location: region:247201-247953:1
so has part: feature:247201-247953:1:exon
subclass of: SO_0000010

850741
type: Gene
SIO_000068: ncbigene

position:247201:1
position: 247201
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:247953:1
position: 247953
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:247201-247953:1:exon

YLR052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IES3
locus tag: YLR052W
product: Ies3p
transcript id: NM_001181939.1
SIO_010081: YLR052W
subclass of: SO_0000673
so part of: YLR052W
location: <247201..>247953
location: region:247201-247953:1
so has part: feature:247201-247953:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:247201-247953:1:exon

YLR052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IES3
locus tag: YLR052W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]
experiment: EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17562861]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:17562861]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Subunit of the INO80 chromatin remodeling complex
codon start: 1
product: Ies3p
translation: MKFEDLLATNKQVQFAHAATQHYKSVKTPDFLEKDPHHKKFHNADGLNQQGSSTPSTATDANAASTASTHTNTTTFKRHIVAVDDISKMNYEMIKNSPGNVITNANQDEIDISTLKTRLYKDNLYAMNDNFLQAVNDQIVTLNAAEQDQETEDPDLSDDEKIDILTKIQENLLEEYQKLSQKERKWFILKELLLDANVELDLFSNRGRKASHPIAFGAVAIPTNVNANSLAFNRTKRRKINKNGLLENIL
SIO_010081: YLR052W
subclass of: SO_0000673
so part of: YLR052W
location: 247201..247953
location: region:247201-247953:1
so has part: feature:247201-247953:1:exon

NP_013153.1
type: Protein
SIO_000068: ncbiprotein

S000004042
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:247201-247953:1:exon

YLR053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NRS1
locus tag: YLR053C
so part of: sequence
location: complement(<248100..>248426)
location: region:248100-248426:-1
so has part: feature:248100-248426:-1:exon
subclass of: SO_0000010

850742
type: Gene
SIO_000068: ncbigene

position:248100:-1
position: 248100
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248426:-1
position: 248426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248100-248426:-1:exon

YLR053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NRS1
locus tag: YLR053C
product: Nrs1p
transcript id: NM_001181940.1
SIO_010081: YLR053C
subclass of: SO_0000673
so part of: YLR053C
location: complement(<248100..>248426)
location: region:248100-248426:-1
so has part: feature:248100-248426:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248100-248426:-1:exon

YLR053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NRS1
locus tag: YLR053C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:35239649]
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:35239649]
experiment: EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:35239649]
experiment: EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:35239649]
experiment: EXISTENCE:expression pattern:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]
experiment: EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]
experiment: EXISTENCE:mutant phenotype:GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:35239649]
experiment: EXISTENCE:physical interaction:GO:0044877 protein-containing complex binding [PMID:35239649]
note: Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2
codon start: 1
product: Nrs1p
translation: MDMLHNKCSDAIKSTSNSNLSNEVDKQKLQYDDLGNTGFSELFEMESQDNNDSIEDFLFFNINLTQEVEFENQRQYEHTKKTKKHNPFYVPSEVVREMVKKHALNGRI
SIO_010081: YLR053C
subclass of: SO_0000673
so part of: YLR053C
location: complement(248100..248426)
location: region:248100-248426:-1
so has part: feature:248100-248426:-1:exon

NP_013154.1
type: Protein
SIO_000068: ncbiprotein

S000004043
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248100-248426:-1:exon

YLR054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSW2
locus tag: YLR054C
so part of: sequence
location: complement(<248717..>250978)
location: region:248717-250978:-1
so has part: feature:248717-250978:-1:exon
subclass of: SO_0000010

850743
type: Gene
SIO_000068: ncbigene

position:248717:-1
position: 248717
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:250978:-1
position: 250978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248717-250978:-1:exon

YLR054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSW2
locus tag: YLR054C
product: Osw2p
transcript id: NM_001181941.1
SIO_010081: YLR054C
subclass of: SO_0000673
so part of: YLR054C
location: complement(join(<248717..250860,250948..>250978))
location: region:248717-250978:-1
so has part: feature:250948-250978:-1:exon
so has part: feature:248717-250860:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:250948-250978:-1:exon

position:250948:-1
position: 250948
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:248717-250860:-1:exon

position:250860:-1
position: 250860
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSW2
locus tag: YLR054C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15590821]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15590821|PMID:24390141]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]
note: hypothetical protein reputedly involved in spore wall assembly
codon start: 1
product: Osw2p
translation: MEENQLTCLIVGETPAAQFLGWRLSLSNSFIILVSQYVSSDELVAWKSTKLGANFYTPNILTKDIKELHHKLKHNGANTYSIDIVLVSAISLQSFETTCRLLSDYTNDNTTVLISTDFGCELEPIAISYFGGKCKCVISISCEVECRQLSLGSYALVNDDQCVITLGLTYCDANFEASPTILENTKAASLELQGIKGSNVRRFLLGLTVAKWMKSKLILDPKQMALKMWELLIPKISLNILSIIYEQFDYEKMLENKSTEIIFKDLVKELLGICFAQCGSKIARFLLVKSQGEEEINFGKIVEYCKGKKLQLINSTANEHPEYLSLPFEPYCFYHRFEYPAQILLHQPIILAKKYGVSCSNLNFLYGFYTRLLTLSGLSINGGRCEHALSMLDSRIGGGINVASGINSGQDFTDGDNEDQDKGKNRVDKNVKEGSFISLTQRFTMTSPLGVNDPALPADLEKLYLGAEYISNCDANTSGGQKRVKSPTKADTGYDDKHLPDDTIHTFEDEYLADEDDFSCLGIDKRSSTKPTKPLEKFGVVAVPHFIRRFSIKRSSKDKSNDMKRPYTTSSLELQLRSNHFMFAKEYQDLHRQLYYEVKPRTQSELDARRRNYSELESQMWKIKHRFNIHRGALPRPRTNPYELLLDHIDVLNRGNTGDILRFTTSRYGGVDTYDSILRDQSTIMELLDKRCAYSPPVLFDNEAKERDHDRDCYQDYNHDHRSH
SIO_010081: YLR054C
subclass of: SO_0000673
so part of: YLR054C
location: complement(join(248717..250860,250948..250978))
location: region:248717-250978:-1
so has part: feature:250948-250978:-1:exon
so has part: feature:248717-250860:-1:exon

NP_013155.2
type: Protein
SIO_000068: ncbiprotein

S000004044
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:250948-250978:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:248717-250860:-1:exon

YLR055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPT8
locus tag: YLR055C
so part of: sequence
location: complement(<251272..>253080)
location: region:251272-253080:-1
so has part: feature:251272-253080:-1:exon
subclass of: SO_0000010

850744
type: Gene
SIO_000068: ncbigene

position:251272:-1
position: 251272
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253080:-1
position: 253080
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251272-253080:-1:exon

YLR055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPT8
locus tag: YLR055C
product: SAGA complex subunit SPT8
transcript id: NM_001181942.1
SIO_010081: YLR055C
subclass of: SO_0000673
so part of: YLR055C
location: complement(<251272..>253080)
location: region:251272-253080:-1
so has part: feature:251272-253080:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251272-253080:-1:exon

YLR055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPT8
locus tag: YLR055C
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10611242]
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:15132995]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10611242]
experiment: EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:9858534]
experiment: EXISTENCE:mutant phenotype:GO:0017025 TBP-class protein binding [PMID:9858534]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12370284]
note: Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters
codon start: 1
product: SAGA complex subunit SPT8
translation: MDEVDDILINNQVVDDEEDDEEMLSGLENDSKQDLEGNDDGGEDEEDDDDDDEDDDDDEDEREDDDEQEDDDGEDDAARMDKTATPTNEHQHDEQKAAAAGAGGAGDSGDAVTKIGSEDVKLSDVDGGVGSREASSSTHEASANGEVYEYYKHMLNAAQIADSYNIYPTAAIPIQTHVNALAVSRGLKYLFLGGSDGYIRKYDLLNTLEGKLSLTILQKHSLAESIQNAGILQSYWENEIPQKKSEMKLSANKTDYEPKVSPVHSLEVQSECLFILSGLQNGGITMQGVRYMEGSIAHYFKGRNGHTQIVNILRLNGQEDRFLSGSWDKRLLEWDLQTGDIVNEFKKSRSELSSLEMRPLYSSVDVSGNVNSGKENENADDDMDSLFGDEDEDEKQDAGNEPVETGDGSNGEENKEQISEESLNIVYDESVFMTSGLNGSVHIWDRRMTQSPALSLERGAGVPPWCLSACWGVDGDHVYAGRRNACVEQFDLKMPSKPIHNLKLPSISGPVSCVKAMPNNKHLLCASRDNIRLYNVEIAVDASNSTTKSSKVPFLIVPGHHGGIISNLYLDPTSRFIISTSGNRGWQGNSTDTTLIYDIDLE
SIO_010081: YLR055C
subclass of: SO_0000673
so part of: YLR055C
location: complement(251272..253080)
location: region:251272-253080:-1
so has part: feature:251272-253080:-1:exon

NP_013156.1
type: Protein
SIO_000068: ncbiprotein

S000004045
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251272-253080:-1:exon

YLR056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSO6
alternative label: SYR1
gene: ERG3
locus tag: YLR056W
gene synonym: PSO6; SYR1
so part of: sequence
location: <253861..>254958
location: region:253861-254958:1
so has part: feature:253861-254958:1:exon
subclass of: SO_0000010

850745
type: Gene
SIO_000068: ncbigene

position:253861:1
position: 253861
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:254958:1
position: 254958
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253861-254958:1:exon

YLR056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSO6
alternative label: SYR1
gene: ERG3
locus tag: YLR056W
gene synonym: PSO6; SYR1
product: C-5 sterol desaturase
transcript id: NM_001181943.1
SIO_010081: YLR056W
subclass of: SO_0000673
so part of: YLR056W
location: <253861..>254958
location: region:253861-254958:1
so has part: feature:253861-254958:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253861-254958:1:exon

YLR056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSO6
alternative label: SYR1
gene: ERG3
locus tag: YLR056W
gene synonym: PSO6; SYR1
EC number: 1.14.19.20
experiment: EXISTENCE:direct assay:GO:0000248 C-5 sterol desaturase activity [PMID:34600]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:21737688]
experiment: EXISTENCE:mutant phenotype:GO:0000248 C-5 sterol desaturase activity [PMID:1864507]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1864507]
note: C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D
codon start: 1
product: C-5 sterol desaturase
translation: MDLVLEVADHYVLDDLYAKVLPASLAANIPVKWQKLLGLNSGFSNSTILQETLNSKNAVKECRRFYGQVPFLFDMSTTSFASLLPRSSILREFLSLWVIVTIFGLLLYLFTASLSYVFVFDKSIFNHPRYLKNQMAMEIKLAVSAIPWMSMLTVPWFVMELNGHSKLYMKIDYENHGVRKLIIEYFTFIFFTDCGVYLAHRWLHWPRVYRALHKPHHKWLVCTPFASHSFHPVDGFLQSISYHIYPLILPLHKVSYLILFTFVNFWTVMIHDGQYLSNNPAVNGTACHTVHHLYFNYNYGQFTTLWDRLGGSYRRPDDSLFDPKLRDAKETWDAQVKEVEHFIKEVEGDDNDRIYENDPNTKKNN
SIO_010081: YLR056W
subclass of: SO_0000673
so part of: YLR056W
location: 253861..254958
location: region:253861-254958:1
so has part: feature:253861-254958:1:exon

NP_013157.1
type: Protein
SIO_000068: ncbiprotein

S000004046
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253861-254958:1:exon

YLR057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MNL2
locus tag: YLR057W
so part of: sequence
location: <255306..>257855
location: region:255306-257855:1
so has part: feature:255306-257855:1:exon
subclass of: SO_0000010

850746
type: Gene
SIO_000068: ncbigene

position:255306:1
position: 255306
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:257855:1
position: 257855
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255306-257855:1:exon

YLR057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MNL2
locus tag: YLR057W
product: putative mannosidase MNL2
transcript id: NM_001181944.1
SIO_010081: YLR057W
subclass of: SO_0000673
so part of: YLR057W
location: <255306..>257855
location: region:255306-257855:1
so has part: feature:255306-257855:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255306-257855:1:exon

YLR057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MNL2
locus tag: YLR057W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21971548]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:21971548]
note: Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
codon start: 1
product: putative mannosidase MNL2
translation: MSIARLVYSLFRRVRSVLLLFITISLLFYYTFQNEIDILNSYALNDSLPSINNYEHNTEGSSKLDPPDLSSTGSDRIATDKENGNVAVDLSDPATLREKNKYFPLLLKGSSHQIGSNLPISSLLTYKEKYPVLFEYSSPSLTSISQNDVHKIQPAMQLPPDVDMIKQIKDIFMKSWNQEQLLLKSNLRRESTWPIDLIDSLDTLYLCGETKLFQDSVNIIEDFDFRVPPLAMEVIDIPDITTRVLEGLLSAYELSMDKRLLNKAKHVADFILRSFDTPNRIPILKYFWKSDLRNRFPDRTVPSGQLTTMALAFIRLSQLTRLNKYFDAVERVFTTIRQSYNEFDMEFMLPDVVDASGCQLLTQEEIENGAHLKGSSIMKSINENFKFVHCQQLGKFLNPPIDDNSLQEQSQYQAYRINEKTVPILENLFKINDLFQSSYDILDGSSKNANAATMDPSIGSEVEAVDEIIEKRNFKDGTKKDSTKNTVGDKSLIDSQTFLTNSISNIFKFMTFRPMLPKQTENKKFNFLNSILTKSQFMPTTNELDVTIRKSYDVSLYSCRLGGILGLSSRVPHRGGVNTKYILPSSLLEMSEIITESCFMLMEEFDGLLPQKFELDPCTDETNGNCEFNGETKSRMIANGEYETFENDLDVGIKVSNYGKGGNDQKAKRNVLSKDGITETQNIKGDTVGSSKSIAEIDGDEVTQIRRVFTLGKDIKPHITTDDTMGSQWKNHPDWPFWVNKVESRRLLDSNIIESIFYMYRISGEQKWRSMGKQSFGILMQELMELNSGAKGLWQIKEFYENGEKVNNDLPSYWFSRTLKYYLLLFSDGDKVSLDKHILTQGGHIIKKK
SIO_010081: YLR057W
subclass of: SO_0000673
so part of: YLR057W
location: 255306..257855
location: region:255306-257855:1
so has part: feature:255306-257855:1:exon

NP_013158.1
type: Protein
SIO_000068: ncbiprotein

S000004047
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255306-257855:1:exon

YLR058C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SHMT2
gene: SHM2
locus tag: YLR058C
gene synonym: SHMT2
so part of: sequence
location: complement(<257992..>259401)
location: region:257992-259401:-1
so has part: feature:257992-259401:-1:exon
subclass of: SO_0000010

850747
type: Gene
SIO_000068: ncbigene

position:257992:-1
position: 257992
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259401:-1
position: 259401
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:257992-259401:-1:exon

YLR058C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SHMT2
gene: SHM2
locus tag: YLR058C
gene synonym: SHMT2
product: glycine hydroxymethyltransferase SHM2
transcript id: NM_001181945.1
SIO_010081: YLR058C
subclass of: SO_0000673
so part of: YLR058C
location: complement(<257992..>259401)
location: region:257992-259401:-1
so has part: feature:257992-259401:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:257992-259401:-1:exon

YLR058C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SHMT2
gene: SHM2
locus tag: YLR058C
gene synonym: SHMT2
EC number: 2.1.2.1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12700234]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:mutant phenotype:GO:0004372 glycine hydroxymethyltransferase activity [PMID:8132653|PMID:9398220]
experiment: EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:8132653]
experiment: EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:8132653|PMID:9398220]
note: Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
codon start: 1
product: glycine hydroxymethyltransferase SHM2
translation: MPYTLSDAHHKLITSHLVDTDPEVDSIIKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILCQQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSHGYATENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMREIADKCGAYLMVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKEYQTQVLKNAKALESEFKNLGYRLVSNGTDSHMVLVSLREKGVDGARVEYICEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGMGEEDFHRIVQYINKAVEFAQQVQQSLPKDACRLKDFKAKVDEGSDVLNTWKKEIYDWAGEYPLAV
SIO_010081: YLR058C
subclass of: SO_0000673
so part of: YLR058C
location: complement(257992..259401)
location: region:257992-259401:-1
so has part: feature:257992-259401:-1:exon

NP_013159.1
type: Protein
SIO_000068: ncbiprotein

S000004048
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:257992-259401:-1:exon

YLR059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNT20
gene: REX2
locus tag: YLR059C
gene synonym: YNT20
so part of: sequence
location: complement(<259738..>260547)
location: region:259738-260547:-1
so has part: feature:259738-260547:-1:exon
subclass of: SO_0000010

850748
type: Gene
SIO_000068: ncbigene

position:259738:-1
position: 259738
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:260547:-1
position: 260547
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259738-260547:-1:exon

YLR059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNT20
gene: REX2
locus tag: YLR059C
gene synonym: YNT20
product: Rex2p
transcript id: NM_001181946.1
SIO_010081: YLR059C
subclass of: SO_0000673
so part of: YLR059C
location: complement(<259738..>260547)
location: region:259738-260547:-1
so has part: feature:259738-260547:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:259738-260547:-1:exon

YLR059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNT20
gene: REX2
locus tag: YLR059C
gene synonym: YNT20
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9933355|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:9933355]
experiment: EXISTENCE:genetic interaction:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10716935]
experiment: EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10716935]
experiment: EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10716935]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9933355]
experiment: EXISTENCE:mutant phenotype:GO:0000175 3'-5'-exoribonuclease activity [PMID:10716935]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9933355]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10716935]
note: 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
codon start: 1
product: Rex2p
translation: MKWLLFPARIVARTRPNLFSLYRRSVSQYLRPRTIQNLQSMAQTPELKTKLFKPLVWIDCEMTGLDHVNDRIIEICCIITDGHLAPVKAADGQGDSHYESVIHYGPEVMNKMNEWCIEHHGNSGLTAKVLASEKTLAQVEDELLEYIQRYIPDKNVGVLAGNSVHMDRLFMVREFPKVIDHLFYRIVDVSSIMEVARRHNPALQARNPKKEAAHTAYSDIKESIAQLQWYMDNYLKPPQETESVESIGSEQPESPSSSTSSLKRQRTDF
SIO_010081: YLR059C
subclass of: SO_0000673
so part of: YLR059C
location: complement(259738..260547)
location: region:259738-260547:-1
so has part: feature:259738-260547:-1:exon

NP_013160.1
type: Protein
SIO_000068: ncbiprotein

S000004049
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259738-260547:-1:exon

YLR060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRS1
locus tag: YLR060W
so part of: sequence
location: <260979..>262766
location: region:260979-262766:1
so has part: feature:260979-262766:1:exon
subclass of: SO_0000010

850749
type: Gene
SIO_000068: ncbigene

position:260979:1
position: 260979
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:262766:1
position: 262766
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:260979-262766:1:exon

YLR060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRS1
locus tag: YLR060W
product: phenylalanine--tRNA ligase subunit beta
transcript id: NM_001181947.1
SIO_010081: YLR060W
subclass of: SO_0000673
so part of: YLR060W
location: <260979..>262766
location: region:260979-262766:1
so has part: feature:260979-262766:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:260979-262766:1:exon

YLR060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRS1
locus tag: YLR060W
EC number: 6.1.1.20
experiment: EXISTENCE:direct assay:GO:0004826 phenylalanine-tRNA ligase activity [PMID:16162501|PMID:166841]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006432 phenylalanyl-tRNA aminoacylation [PMID:16162501|PMID:166841]
experiment: EXISTENCE:direct assay:GO:0009328 phenylalanine-tRNA ligase complex [PMID:3049607]
note: Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
codon start: 1
product: phenylalanine--tRNA ligase subunit beta
translation: MPTVSVNKQQLFDLLGKNYTSQEFDELCFEFGMEMDEDTTEEALKTGEEPELKLDISANRYDLLCIEGISQSLNEYLERKERPDYKLSKPTTKLIIDKSTEQIRPFATAAVLRNIKLNEKSYASFIALQDKLHANLCRNRSLVAMGTHDLDSIEGPFHYRALPPKDIKFVPLNQTQEFTGDKLIEFYKSPEQKNNIGRYVHIIEDSPVFPVIMDSKDRVCSLPPLINSEHSKISVNTRNILIDITATDKTKAEIVLNILTTMFSRYCDEPFTVEPVEIVSEHNGQSRLAPNFNDRIMDVSIKYINSCLGLDQSADEIAHCLKKMSLHAVQSKEDKDILHVDIPVTRPDILHACDIMEDAAVGYGFNNLPKGEKLSNANFIAKPLPINKVSDIFRVASSQATWVEVLPLTLCSHDENFKFLRQSDNGDLAVKLANPKTLEYQVVRTTLLPGILKTVKENRKHSLPIKVFETGDVVFKDDKLERKAYNERHWAAIYVGKNSGFEIIQGLLGKIMQTFRTEWIADYGAAASGRGYWIEEDDSVKTYFPGRGAKVMFRSKEGAEPKQIGHLGVLHPEVMMNFDVPFAASFVEVNAEVFL
SIO_010081: YLR060W
subclass of: SO_0000673
so part of: YLR060W
location: 260979..262766
location: region:260979-262766:1
so has part: feature:260979-262766:1:exon

NP_013161.1
type: Protein
SIO_000068: ncbiprotein

S000004050
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:260979-262766:1:exon

YLR061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL22A
locus tag: YLR061W
so part of: sequence
location: <263194..>263948
location: region:263194-263948:1
so has part: feature:263194-263948:1:exon
subclass of: SO_0000010

850750
type: Gene
SIO_000068: ncbigene

position:263194:1
position: 263194
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263948:1
position: 263948
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263194-263948:1:exon

YLR061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL22A
locus tag: YLR061W
product: ribosomal 60S subunit protein L22A
transcript id: NM_001181948.1
SIO_010081: YLR061W
subclass of: SO_0000673
so part of: YLR061W
location: join(<263194..263205,263595..>263948)
location: region:263194-263948:1
so has part: feature:263194-263205:1:exon
so has part: feature:263595-263948:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263194-263205:1:exon

position:263205:1
position: 263205
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:263595-263948:1:exon

position:263595:1
position: 263595
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL22A
locus tag: YLR061W
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:27478489]
note: Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L22A
translation: MAPNTSRKQKIAKTFTVDVSSPTENGVFDPASYAKYLIDHIKVEGAVGNLGNAVTVTEDGTVVTVVSTAKFSGKYLKYLTKKYLKKNQLRDWIRFVSTKTNEYRLAFYQVTPEEDEEEDEE
SIO_010081: YLR061W
subclass of: SO_0000673
so part of: YLR061W
location: join(263194..263205,263595..263948)
location: region:263194-263948:1
so has part: feature:263194-263205:1:exon
so has part: feature:263595-263948:1:exon

NP_013162.1
type: Protein
SIO_000068: ncbiprotein

S000004051
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263194-263205:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:263595-263948:1:exon

YLR063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BMT6
locus tag: YLR063W
so part of: sequence
location: <264157..>265254
location: region:264157-265254:1
so has part: feature:264157-265254:1:exon
subclass of: SO_0000010

850752
type: Gene
SIO_000068: ncbigene

position:264157:1
position: 264157
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:265254:1
position: 265254
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264157-265254:1:exon

YLR063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BMT6
locus tag: YLR063W
product: 25S rRNA (uracil2843-N3)-methyltransferase
transcript id: NM_001181950.1
SIO_010081: YLR063W
subclass of: SO_0000673
so part of: YLR063W
location: <264157..>265254
location: region:264157-265254:1
so has part: feature:264157-265254:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264157-265254:1:exon

YLR063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BMT6
locus tag: YLR063W
EC number: 2.1.1.312
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24335083|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0070042 rRNA (uridine-N3-)-methyltransferase activity [PMID:24335083]
experiment: EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:24335083]
note: Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
codon start: 1
product: 25S rRNA (uracil2843-N3)-methyltransferase
translation: MLLMRRFAFLTSSVYFKYIPIYSQYHYSSQFPINMNPKKVAQLPVHNKSTLPPQEIIDLFKITFLEELYPKDQDNEKSPLTEQIQAVKSDLYNRDYNAAFNNDSKRIAYCCRWSPSRATSYASVFAHFPELLKIIRCEIDDKDSNVLCIGGGAGGELVALASIFTLSRDFSSKFASALKIDNEVNKKPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGDSEAESFNVNFTHKDCLQMTEPQDIKIYQGLDLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLLILESAGSYSHITINNKKFPIQFLIDTILVGNRKDKGTTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLYVKN
SIO_010081: YLR063W
subclass of: SO_0000673
so part of: YLR063W
location: 264157..265254
location: region:264157-265254:1
so has part: feature:264157-265254:1:exon

NP_013164.1
type: Protein
SIO_000068: ncbiprotein

S000004053
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264157-265254:1:exon

YLR064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PER33
locus tag: YLR064W
so part of: sequence
location: <265456..>266277
location: region:265456-266277:1
so has part: feature:265456-266277:1:exon
subclass of: SO_0000010

850753
type: Gene
SIO_000068: ncbigene

position:265456:1
position: 265456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266277:1
position: 266277
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:265456-266277:1:exon

YLR064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PER33
locus tag: YLR064W
product: Per33p
transcript id: NM_001181951.1
SIO_010081: YLR064W
subclass of: SO_0000673
so part of: YLR064W
location: <265456..>266277
location: region:265456-266277:1
so has part: feature:265456-266277:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:265456-266277:1:exon

YLR064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PER33
locus tag: YLR064W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20498018|PMID:14562095|PMID:26928762]
note: Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
codon start: 1
product: Per33p
translation: MTVPRNRPMAPFGTIIKSRIKQPQFYWFIGHFLTIFNFIQFHLSITSKQNQLSCYRRSLFYISVTYAIVLYQFFKSDQLKFNFTLLRQEMKKLDNLQYFAMLFILFLLSQFNIIISGSLYSPVIFSIFHFLNYFKENLLPFLPLIPLNLKNLLNSKITVFIQNYNGFFLQMAQVFEIICGLRVGLFLVPFNFFLLLVRRANVSFEVVGTMLAGLTYVWFFKLRYLQSESMRQIFKQYVLRLDAYVSRTLPPYCSRLWNGYKNFVMTVFWKIPV
SIO_010081: YLR064W
subclass of: SO_0000673
so part of: YLR064W
location: 265456..266277
location: region:265456-266277:1
so has part: feature:265456-266277:1:exon

NP_013165.1
type: Protein
SIO_000068: ncbiprotein

S000004054
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:265456-266277:1:exon

YLR065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ENV10
gene: SND2
locus tag: YLR065C
gene synonym: ENV10
so part of: sequence
location: complement(<266373..>266918)
location: region:266373-266918:-1
so has part: feature:266373-266918:-1:exon
subclass of: SO_0000010

850754
type: Gene
SIO_000068: ncbigene

position:266373:-1
position: 266373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266918:-1
position: 266918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:266373-266918:-1:exon

YLR065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ENV10
gene: SND2
locus tag: YLR065C
gene synonym: ENV10
product: Snd2p
transcript id: NM_001181952.1
SIO_010081: YLR065C
subclass of: SO_0000673
so part of: YLR065C
location: complement(<266373..>266918)
location: region:266373-266918:-1
so has part: feature:266373-266918:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:266373-266918:-1:exon

YLR065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ENV10
gene: SND2
locus tag: YLR065C
gene synonym: ENV10
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]
note: Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control
codon start: 1
product: Snd2p
translation: MAGKAGRKQASSNAKIIQGLYKQVSLFLGMAIVRLFISRKVTIGQWIKLVALNVPMFVALYIIVLSGKPKYDGNRVVKQGIDLNDNTNLISYFFDLIYLSLFGNIGIIAFRTFKFWWCLLLCPIYAGYKLYGLKNMFMPGAQQTQADNRSKNANEGQSKSKRQMKRERRGETDSKIKYKYR
SIO_010081: YLR065C
subclass of: SO_0000673
so part of: YLR065C
location: complement(266373..266918)
location: region:266373-266918:-1
so has part: feature:266373-266918:-1:exon

NP_013166.1
type: Protein
SIO_000068: ncbiprotein

S000004055
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:266373-266918:-1:exon

YLR066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC3
locus tag: YLR066W
so part of: sequence
location: <267169..>267723
location: region:267169-267723:1
so has part: feature:267169-267723:1:exon
subclass of: SO_0000010

850755
type: Gene
SIO_000068: ncbigene

position:267169:1
position: 267169
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:267723:1
position: 267723
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267169-267723:1:exon

YLR066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC3
locus tag: YLR066W
product: signal peptidase complex subunit SPC3
transcript id: NM_001181953.1
SIO_010081: YLR066W
subclass of: SO_0000673
so part of: YLR066W
location: <267169..>267723
location: region:267169-267723:1
so has part: feature:267169-267723:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267169-267723:1:exon

YLR066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC3
locus tag: YLR066W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:1846444|PMID:8910564]
experiment: EXISTENCE:direct assay:GO:0006465 signal peptide processing [PMID:9148931]
experiment: EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:9148930|PMID:9148931]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:9148931]
note: Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p
codon start: 1
product: signal peptidase complex subunit SPC3
translation: MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLINNNAFSVPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNTDLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGKFEGKDLVFKLHWNVQPWVGLLTYGETVGNYTLTVENKNKV
SIO_010081: YLR066W
subclass of: SO_0000673
so part of: YLR066W
location: 267169..267723
location: region:267169-267723:1
so has part: feature:267169-267723:1:exon

NP_013167.1
type: Protein
SIO_000068: ncbiprotein

S000004056
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267169-267723:1:exon

YLR067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PET309
locus tag: YLR067C
so part of: sequence
location: complement(<267813..>270710)
location: region:267813-270710:-1
so has part: feature:267813-270710:-1:exon
subclass of: SO_0000010

850756
type: Gene
SIO_000068: ncbigene

position:267813:-1
position: 267813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270710:-1
position: 270710
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267813-270710:-1:exon

YLR067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PET309
locus tag: YLR067C
product: Pet309p
transcript id: NM_001181954.1
SIO_010081: YLR067C
subclass of: SO_0000673
so part of: YLR067C
location: complement(<267813..>270710)
location: region:267813-270710:-1
so has part: feature:267813-270710:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267813-270710:-1:exon

YLR067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PET309
locus tag: YLR067C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:25181249]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9692914]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:7664742]
experiment: EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:7664742]
experiment: EXISTENCE:mutant phenotype:GO:0070134 positive regulation of mitochondrial translational initiation [PMID:18039654|PMID:7664742]
note: Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)
codon start: 1
product: Pet309p
translation: MKRCAPAVLRNYNYKKGIWSTGVPDHIRKLLRDKSTSPLCSQDERNLVSYFMARGSVPLKSVGSGLTKKATTSITSNSATTTFERQYLIKYLYRHQAYGNVIKIAQKFLYTTIGSQRLLKQDASLPELKKFLLSLLILQRGIQLDQAISDIIQRFLLTQKTMVIDLINSIFSRMVIMNMHEEAVYKWVKWMKLVNGHCEFTNYMENKIVLRNFLSFMRQSNVRPDYLSYLKAIQLTQGPAIASQFATTLLFLLTYIRKFSSAEAVWNYKCEHNLPIVSSDLTCILKTYCHMQKFNLVSSTYWKYPDAQHDQNQFDYLLVAHSRLHNWDALQQQFNALFGIGKLPSIQHYGILMYTMARIGELDSVNKLYTQLLRRGMIPTYAVLQSLLYAHYKVGDFAACFSHFELFKKYDITPSTATHTIMLKVYRGLNDLDGAFRILKRLSEDPSVEITEGHFALLIQMCCKTTNHLIAQELFNLMTEHYNIQHTGKSISALMDVYIESNRPTEAIALFEKHSKNLSWRDGLISVYNKAIKAYIGLRNANKCEELFDKITTSKLAVNSEFYKMMIKFLVTLNEDCETALSIIDQLIKHSVIKVDATHFEIIMEAYDKEGYRDGIINLYKTMSQNKVPANSKILYYILKAVAKKSLQNNEEIKETINMVEDIMENAANGTLDVTYNKLHPSVMAWPMRMIVKHDSPQRALELYNRYNELFFKKHDWISNNNKFVMMRSLLVLLAQIEQWKDFETLFAKYMDRIENIENLPSSTTPNIKLRSIFSGLFPYKVSQLIAMNKIDELPLLWKKLREKGFILDNISWNSAVEALFKDPRTLSYGMKIVDDTLIHGYNLIHKFRLLTKLSEDKTQSSDKSWPTLKMKEKEPNKFQPRLYLKSDTYNSIMRQLDTYLDGIDDLKTLEDQVRDFISNYKYFMKDYLLMPRSKINKWEQIEMRHLSYFKELRKSKRVLPVSKF
SIO_010081: YLR067C
subclass of: SO_0000673
so part of: YLR067C
location: complement(267813..270710)
location: region:267813-270710:-1
so has part: feature:267813-270710:-1:exon

NP_013168.1
type: Protein
SIO_000068: ncbiprotein

S000004057
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267813-270710:-1:exon

YLR068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FYV7
locus tag: YLR068W
so part of: sequence
location: <271008..>271463
location: region:271008-271463:1
so has part: feature:271008-271463:1:exon
subclass of: SO_0000010

850757
type: Gene
SIO_000068: ncbigene

position:271008:1
position: 271008
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271463:1
position: 271463
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271008-271463:1:exon

YLR068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FYV7
locus tag: YLR068W
product: Fyv7p
transcript id: NM_001181955.1
SIO_010081: YLR068W
subclass of: SO_0000673
so part of: YLR068W
location: <271008..>271463
location: region:271008-271463:1
so has part: feature:271008-271463:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271008-271463:1:exon

YLR068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FYV7
locus tag: YLR068W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]
note: Nucleolar protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
codon start: 1
product: Fyv7p
translation: MGTAKQNQNRKKFTREYKVKEIQRSITKKTRLRKEYLKALKDEGYAVPEKEPKTVAKESVRKIKEARAIEGKKKLDEKKEIKKQRKRMQKDELNKQRNEQLERIRVSKEKFQRREDRKKKLTQRTRTGQPLMGPKIEDLLDKIKTDDTYTS
SIO_010081: YLR068W
subclass of: SO_0000673
so part of: YLR068W
location: 271008..271463
location: region:271008-271463:1
so has part: feature:271008-271463:1:exon

NP_013169.1
type: Protein
SIO_000068: ncbiprotein

S000004058
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271008-271463:1:exon

YLR069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MEF1
locus tag: YLR069C
so part of: sequence
location: complement(<271630..>273915)
location: region:271630-273915:-1
so has part: feature:271630-273915:-1:exon
subclass of: SO_0000010

850758
type: Gene
SIO_000068: ncbigene

position:271630:-1
position: 271630
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273915:-1
position: 273915
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271630-273915:-1:exon

YLR069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MEF1
locus tag: YLR069C
product: Mef1p
transcript id: NM_001181956.1
SIO_010081: YLR069C
subclass of: SO_0000673
so part of: YLR069C
location: complement(<271630..>273915)
location: region:271630-273915:-1
so has part: feature:271630-273915:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271630-273915:-1:exon

YLR069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MEF1
locus tag: YLR069C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1935960]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1935960]
note: Mitochondrial elongation factor involved in translational elongation
codon start: 1
product: Mef1p
translation: MSVQKMMWVPRKMVGGRIPFFTCSKVFSGFSRRSFHESPLARSTYEEEKVLVDEIKQKLTPDDIGRCNKLRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYCSWDKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGSDPFRAIEQLNSKLKIPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNGEIIEKGPVPENLKPLMEEKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIARSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTALDVSNNEAKVNLVPAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYITNVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGIDCASGDTFTDGSVQYSMSSMYVPDAVVSLSITPNSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISGMGELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPVDDITKGNIFETAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVLDVKMLINDGAIHAVDSNELSFKTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTENGHDEFTLKAECALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEFQKKQAKK
SIO_010081: YLR069C
subclass of: SO_0000673
so part of: YLR069C
location: complement(271630..273915)
location: region:271630-273915:-1
so has part: feature:271630-273915:-1:exon

NP_013170.1
type: Protein
SIO_000068: ncbiprotein

S000004059
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271630-273915:-1:exon

YLR070C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: XYL2
locus tag: YLR070C
so part of: sequence
location: complement(<274141..>275211)
location: region:274141-275211:-1
so has part: feature:274141-275211:-1:exon
subclass of: SO_0000010

850759
type: Gene
SIO_000068: ncbigene

position:274141:-1
position: 274141
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:275211:-1
position: 275211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274141-275211:-1:exon

YLR070C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: XYL2
locus tag: YLR070C
product: D-xylulose reductase XYL2
transcript id: NM_001181957.1
SIO_010081: YLR070C
subclass of: SO_0000673
so part of: YLR070C
location: complement(<274141..>275211)
location: region:274141-275211:-1
so has part: feature:274141-275211:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274141-275211:-1:exon

YLR070C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: XYL2
locus tag: YLR070C
EC number: 1.1.1.9
experiment: EXISTENCE:direct assay:GO:0005999 xylulose biosynthetic process [PMID:10486580]
experiment: EXISTENCE:direct assay:GO:0046526 D-xylulose reductase activity [PMID:10486580]
note: Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect
codon start: 1
product: D-xylulose reductase XYL2
translation: MTDLTTQEAIVLERPGKITLTNVSIPKISDPNEVIIQIKATGICGSDIHYYTHGRIANYVVESPMVLGHESSGIVALIGENVKTLKVGDRVALEPGIPDRFSPEMKEGRYNLDPNLKFAATPPFDGTLTKYYKTMKDFVYKLPDDVSFEEGALIEPLSVAIHANKLAKIKFGARCVVFGAGPIGLLAGKVASVFGAADVVFVDLLENKLETARQFGATHIVNSGDLPHGVTVDSVIKKAIGKKGADVVFECSGAEPCVRAGIEVCKAGGTIVQVGMGQEEIQFPISIIPTKELTFQGCFRYCQGDYSDSIELVSSRKLSLKPFITHRYSFKDAVEAFEETSHHPLNNIKTIIEGPE
SIO_010081: YLR070C
subclass of: SO_0000673
so part of: YLR070C
location: complement(274141..275211)
location: region:274141-275211:-1
so has part: feature:274141-275211:-1:exon

NP_013171.1
type: Protein
SIO_000068: ncbiprotein

S000004060
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274141-275211:-1:exon

YLR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MED14
gene: RGR1
locus tag: YLR071C
gene synonym: MED14
so part of: sequence
location: complement(<275378..>278626)
location: region:275378-278626:-1
so has part: feature:275378-278626:-1:exon
subclass of: SO_0000010

850760
type: Gene
SIO_000068: ncbigene

position:275378:-1
position: 275378
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:278626:-1
position: 278626
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:275378-278626:-1:exon

YLR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MED14
gene: RGR1
locus tag: YLR071C
gene synonym: MED14
product: Rgr1p
transcript id: NM_001181958.1
SIO_010081: YLR071C
subclass of: SO_0000673
so part of: YLR071C
location: complement(<275378..>278626)
location: region:275378-278626:-1
so has part: feature:275378-278626:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:275378-278626:-1:exon

YLR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MED14
gene: RGR1
locus tag: YLR071C
gene synonym: MED14
experiment: EXISTENCE:direct assay:GO:0001093 TFIIB-class transcription factor binding [PMID:27688401]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16452140]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11470794]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
codon start: 1
product: Rgr1p
translation: MTTTIGSPQMLANEERLSNEMHALKNRSEQNGQEQQGPVKNTQLHGPSATDPETTATQKESLEMVPKDTSAATMTSAPPPALPHVEINQVSLALVIRNLTVFTMKELAQYMKTNVHTQANEPNSAKKIRFLQLIIFLRTQFLKLYVLVKWTRTIKQNNFHVLIDLLNWFRTTNMNVNNCIWALKSSLNSMTNAKLPNVDLVTALEVLSLGRPNLPTHNFKLSGVSNSMDMVDGMAKVPIGLILQRLKDLNLTVSIKIALMNIPKPLNSYHIKNGRIYFTVPNEFEIQLSTVNRQSPLFFVDLKLLFNTEAEQTVSAVTEATSTNGDSENNEENSSSNGNNLPLNKPRLEKLINEILLKSNDPLLSLYNFLHKYVLTLQLYMVHREFLKLANGGKFSKSNLIHNYDSKKSTITVRYWLNGKMDSKGKITIGIQRTTESLILKWDNQSASRAKNMPVIYNNIVSNIEGILDEIMFNHARIIRSELLARDIFQEDEENSDVLLFQLPTTCVSMAPIQLKIDLLSGQFYFRNPTPLLSNYASKINRAEGPEELARILQQLKLDKIIHVLTTMFENTGWSCSRIIKIDKPIRTQVNTGGESVVKKEDNKYAIAGNSTTNSDVSLLLQRDLFIRLPHWPLNWYLILSIISSKTSCVVEKRIGKIVSQRGKWNLKYLDNSNVMTVKLESITYQKIMILQRTILNRIINHMLIDSLNQLEIRNKICSSEMINEQKLPQYIIQGSNTNDNISIITLELESFLEGSKALNSILESSMFLRIDYSNSQIRLYAKFKRNTMMIQCQIDKLYIHFVQEEPLAFYLEESFTNLGIIVQYLTKFRQKLMQLVVLTDVVERLHKNFESENFKIIALQPNEISFKYLSNNDEDDKDCTIKISTNDDSIKNLTVQLSPSNPQHIIQPFLDNSKMDYHFIFSYLQFTSSLFKALKVILNERGGKFHESGSQYSTMVNIGLHNLNEYQIVYYNPQAGTKITICIELKTVLHNGRDKIQFHIHFADVAHITTKSPAYPMMHQVRNQVFMLDTKRLGTPESVKPANASHAIRLGNGVACDPSEIEPILMEIHNILKVDSNSSSS
SIO_010081: YLR071C
subclass of: SO_0000673
so part of: YLR071C
location: complement(275378..278626)
location: region:275378-278626:-1
so has part: feature:275378-278626:-1:exon

NP_013172.1
type: Protein
SIO_000068: ncbiprotein

S000004061
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:275378-278626:-1:exon

YLR072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LTC1
gene: LAM6
locus tag: YLR072W
gene synonym: LTC1
so part of: sequence
location: <278862..>280943
location: region:278862-280943:1
so has part: feature:278862-280943:1:exon
subclass of: SO_0000010

850761
type: Gene
SIO_000068: ncbigene

position:278862:1
position: 278862
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280943:1
position: 280943
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278862-280943:1:exon

YLR072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LTC1
gene: LAM6
locus tag: YLR072W
gene synonym: LTC1
product: Lam6p
transcript id: NM_001181959.1
SIO_010081: YLR072W
subclass of: SO_0000673
so part of: YLR072W
location: <278862..>280943
location: region:278862-280943:1
so has part: feature:278862-280943:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278862-280943:1:exon

YLR072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LTC1
gene: LAM6
locus tag: YLR072W
gene synonym: LTC1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0032366 intracellular sterol transport [PMID:25987606]
experiment: EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane [PMID:25987606|PMID:26001273|PMID:26119743]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:25987606|PMID:26001273|PMID:26119743]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:25987606]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:26119743]
note: Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes
codon start: 1
product: Lam6p
translation: MWGDSMRELGDAMDNELNAVKPVVEEGGMDGARKFIKGKSFQKSSTEHMLISPGRDGSVPLNGLKSSPADPHLSDVNSILDNHRGGGETALTSVNNIIMATSTNGDSDGVDGDAKRPSISNCSSRSSFFDTVLSTFSLKSNSQDTVTNEVKNIEVQFASEEANKKFRQMFKPLAPNTRLITDYFCYFHREFPYQGRIYLSNTHLCFNSTVLNWMAKLQIPLNEIKYLDKVTTNSSAISVETVTNRYTFSGFIARDEVFQLITRVWSKENLTNINDVLEVDERVSKKKGISSTPSSIFNNVSTNAYNDFISTTTTEPTSRASYMSENDMLIEEAIRSVDDYMGTPRASPSSSSSSSSSSSSLGSSTTYYCRPVYRLKPNAPFQYEGPFHVQETMDFPYKPEANNEYVLLERQFSVPPGLLFIMMFNEDNPVFELSFLKTQDSSNISHIGTFEKVNKDGQHYREFQYTKQLHFPVGPKSTNCEVAEILLHCDWERYINVLSITRTPNVPSGTSFSTRTRYMFRWDDQGQGCILKISFWVDWNASSWIKPMVESNCKNGQISATKDLVKLVEEFVEKYVELSKEKADTLKPLPSVTSFGSPRKVAAPELTMVQPESKPEAEAEISEIGSDRWRFNWVNIIILVLLVLNLLYLMKLNKKMDKLTNLMTHKDEVVAHATLLDIPAKVQWSRPRRGDVL
SIO_010081: YLR072W
subclass of: SO_0000673
so part of: YLR072W
location: 278862..280943
location: region:278862-280943:1
so has part: feature:278862-280943:1:exon

NP_013173.1
type: Protein
SIO_000068: ncbiprotein

S000004062
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278862-280943:1:exon

YLR073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RFU1
locus tag: YLR073C
so part of: sequence
location: complement(<281019..>281621)
location: region:281019-281621:-1
so has part: feature:281019-281621:-1:exon
subclass of: SO_0000010

850762
type: Gene
SIO_000068: ncbigene

position:281019:-1
position: 281019
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281621:-1
position: 281621
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281019-281621:-1:exon

YLR073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RFU1
locus tag: YLR073C
product: Rfu1p
transcript id: NM_001181960.1
SIO_010081: YLR073C
subclass of: SO_0000673
so part of: YLR073C
location: complement(<281019..>281621)
location: region:281019-281621:-1
so has part: feature:281019-281621:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281019-281621:-1:exon

YLR073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RFU1
locus tag: YLR073C
experiment: EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:19410548]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:24962567|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:19410548]
note: Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes
codon start: 1
product: Rfu1p
translation: MKSSKQLVQDAKDYRFNPAIPLRIYLKTCIGILEKAQCAFQANDLSLSFIYYFRYVDLLTNKLSRHPELLRMDASSSSSSSYIHKREYLQLIKLEVPAVCKIIESLRTQIDSQYSKLQTSLANNIAKPNINANTTPVQVEQQPLPKKSFDEYSFNQSISFFQKISNAQLNTGASSQSQATARDEAYRLNYPELPRLTFST
SIO_010081: YLR073C
subclass of: SO_0000673
so part of: YLR073C
location: complement(281019..281621)
location: region:281019-281621:-1
so has part: feature:281019-281621:-1:exon

NP_013174.1
type: Protein
SIO_000068: ncbiprotein

S000004063
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281019-281621:-1:exon

YLR074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUD20
locus tag: YLR074C
so part of: sequence
location: complement(<281956..>282456)
location: region:281956-282456:-1
so has part: feature:281956-282456:-1:exon
subclass of: SO_0000010

850763
type: Gene
SIO_000068: ncbigene

position:281956:-1
position: 281956
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:282456:-1
position: 282456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281956-282456:-1:exon

YLR074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUD20
locus tag: YLR074C
product: Bud20p
transcript id: NM_001181961.1
SIO_010081: YLR074C
subclass of: SO_0000673
so part of: YLR074C
location: complement(<281956..>282456)
location: region:281956-282456:-1
so has part: feature:281956-282456:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281956-282456:-1:exon

YLR074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUD20
locus tag: YLR074C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11452010|PMID:23212245]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23045392|PMID:23212245]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23045392|PMID:23212245]
experiment: EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:23045392]
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:23045392|PMID:23212245]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:23045392|PMID:23212245]
note: C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593
codon start: 1
product: Bud20p
translation: MGRYSVKRYKTKRRTRDLDLIYNDLSTKESVQKLLNQPLDETKPGLGQHYCIHCAKYMETAIALKTHLKGKVHKRRVKELRGVPYTQEVSDAAAGYNLNKFLNRVQEITQSVGPEKESNEALLKEHLDSTLANVKTTEPTLPWAAADAEANTAAVTEAESTASAST
SIO_010081: YLR074C
subclass of: SO_0000673
so part of: YLR074C
location: complement(281956..282456)
location: region:281956-282456:-1
so has part: feature:281956-282456:-1:exon

NP_013175.1
type: Protein
SIO_000068: ncbiprotein

S000004064
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281956-282456:-1:exon

YLR075W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GRC5
alternative label: QSR1
gene: RPL10
locus tag: YLR075W
gene synonym: GRC5; QSR1
so part of: sequence
location: <282927..>283592
location: region:282927-283592:1
so has part: feature:282927-283592:1:exon
subclass of: SO_0000010

850764
type: Gene
SIO_000068: ncbigene

position:282927:1
position: 282927
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283592:1
position: 283592
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282927-283592:1:exon

YLR075W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GRC5
alternative label: QSR1
gene: RPL10
locus tag: YLR075W
gene synonym: GRC5; QSR1
product: ribosomal 60S subunit protein L10
transcript id: NM_001181962.1
SIO_010081: YLR075W
subclass of: SO_0000673
so part of: YLR075W
location: <282927..>283592
location: region:282927-283592:1
so has part: feature:282927-283592:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282927-283592:1:exon

YLR075W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GRC5
alternative label: QSR1
gene: RPL10
locus tag: YLR075W
gene synonym: GRC5; QSR1
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:18824477|PMID:9580698]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:18824477]
note: Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant
codon start: 1
product: ribosomal 60S subunit protein L10
translation: MARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKATVDEFPLCVHLVSNELEQLSSEALEAARICANKYMTTVSGRDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGKPHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPGQQKIILSKKWGFTNLDRPEYLKKREAGEVKDDGAFVKFLSKKGSLENNIREFPEYFAAQA
SIO_010081: YLR075W
subclass of: SO_0000673
so part of: YLR075W
location: 282927..283592
location: region:282927-283592:1
so has part: feature:282927-283592:1:exon

NP_013176.1
type: Protein
SIO_000068: ncbiprotein

S000004065
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282927-283592:1:exon

YLR077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BCA1
gene: FMP25
locus tag: YLR077W
gene synonym: BCA1
so part of: sequence
location: <283872..>285623
location: region:283872-285623:1
so has part: feature:283872-285623:1:exon
subclass of: SO_0000010

850766
type: Gene
SIO_000068: ncbigene

position:283872:1
position: 283872
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:285623:1
position: 285623
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:283872-285623:1:exon

YLR077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BCA1
gene: FMP25
locus tag: YLR077W
gene synonym: BCA1
product: Fmp25p
transcript id: NM_001181964.1
SIO_010081: YLR077W
subclass of: SO_0000673
so part of: YLR077W
location: <283872..>285623
location: region:283872-285623:1
so has part: feature:283872-285623:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:283872-285623:1:exon

YLR077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BCA1
gene: FMP25
locus tag: YLR077W
gene synonym: BCA1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21168530]
experiment: EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:21168530]
note: Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
codon start: 1
product: Fmp25p
translation: MSFRLFTRTSQRLPRLNWVSPIRRYAKQPQYDEAELFAENINHGAYKAKKRPSDEHFQWPEKSPDQITKESELQWERMAKLSAVGQGILILVVVGGLGTAYLRWPELKSWWLIKMNGGRINATQEQSGQDSLEKLIRQKAKNLLREIPQVPAFQLGIDHPGVYIWGRCHSKDSLFPVRVPNLDGRKFRDILLAPSDDFNTNFAIDEKGDLISWDDLGQTKTILPDQDLTSMKYSSHFLYALNKKGEILVIPIRTPDLIASQVSSRRSKLLPWKTKLRYDWKLQTNQIFNGKEGEKRVVQFDAGSHHLVLLSNLGKAYCCATGNDQKQAQVSKGQFGIPTFSQFDEFPPNNQLFEIELLNKFKHEGEDVVRKREIKKIACGSYHTLAIDKTGEIYAFGWNRFGQLALPISYNLEYVSFPRSVTHAFKPHFPGMTNWKCVDIHCDDETSFVTIRKPGSTSDHHYFAFGNGLFGELGNNTFKNSQCDPIKIKSDDKKLTNWSCGSHCVFTETEQENEVIAWGNNDHGQLGIGKKTMKCAKPMNIPEVLKPGQDTTDLDSIYNSKLHLKKEQRVVTNGNKSCLYWRV
SIO_010081: YLR077W
subclass of: SO_0000673
so part of: YLR077W
location: 283872..285623
location: region:283872-285623:1
so has part: feature:283872-285623:1:exon

NP_013178.1
type: Protein
SIO_000068: ncbiprotein

S000004067
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:283872-285623:1:exon

YLR078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEC32
gene: BOS1
locus tag: YLR078C
gene synonym: SEC32
so part of: sequence
location: complement(<285736..>286559)
location: region:285736-286559:-1
so has part: feature:285736-286559:-1:exon
subclass of: SO_0000010

850767
type: Gene
SIO_000068: ncbigene

position:285736:-1
position: 285736
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286559:-1
position: 286559
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285736-286559:-1:exon

YLR078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEC32
gene: BOS1
locus tag: YLR078C
gene synonym: SEC32
product: Bos1p
transcript id: NM_001181965.1
SIO_010081: YLR078C
subclass of: SO_0000673
so part of: YLR078C
location: complement(join(<285736..286467,286557..>286559))
location: region:285736-286559:-1
so has part: feature:286557-286559:-1:exon
so has part: feature:285736-286467:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:286557-286559:-1:exon

position:286557:-1
position: 286557
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:285736-286467:-1:exon

position:286467:-1
position: 286467
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEC32
gene: BOS1
locus tag: YLR078C
gene synonym: SEC32
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11001058]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:1396561]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:8500167]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:1396561]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8500167]
experiment: EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:8500167]
note: v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating
codon start: 1
product: Bos1p
translation: MNALYNHAVKQKNQLQQELARFEKNSVTAPISLQGSISATLVSLEKTVKQYAEHLNRYKEDTNAEEIDPKFANRLATLTQDLHDFTAKFKDLKQSYNENNSRTQLFGSGASHVMDSDNPFSTSETIMNKRNVGGASANGKEGSSNGGGLPLYQGLQKEQSVFERGNAQLDYILEMGQQSFENIVEQNKILSKVQDRMSNGLRTLGVSEQTITSINKRVFKDKLVFWIALILLIIGIYYVLKWLR
SIO_010081: YLR078C
subclass of: SO_0000673
so part of: YLR078C
location: complement(join(285736..286467,286557..286559))
location: region:285736-286559:-1
so has part: feature:286557-286559:-1:exon
so has part: feature:285736-286467:-1:exon

NP_013179.1
type: Protein
SIO_000068: ncbiprotein

S000004068
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:286557-286559:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:285736-286467:-1:exon

YLR079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BYC1
alternative label: SDB25
gene: SIC1
locus tag: YLR079W
gene synonym: BYC1; SDB25
so part of: sequence
location: <286820..>287674
location: region:286820-287674:1
so has part: feature:286820-287674:1:exon
subclass of: SO_0000010

850768
type: Gene
SIO_000068: ncbigene

position:286820:1
position: 286820
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:287674:1
position: 287674
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286820-287674:1:exon

YLR079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BYC1
alternative label: SDB25
gene: SIC1
locus tag: YLR079W
gene synonym: BYC1; SDB25
product: cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1
transcript id: NM_001181966.1
SIO_010081: YLR079W
subclass of: SO_0000673
so part of: YLR079W
location: <286820..>287674
location: region:286820-287674:1
so has part: feature:286820-287674:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:286820-287674:1:exon

YLR079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BYC1
alternative label: SDB25
gene: SIC1
locus tag: YLR079W
gene synonym: BYC1; SDB25
experiment: EXISTENCE:direct assay:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:7954792]
experiment: EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:7954792|PMID:8421781]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155|PMID:11792824|PMID:16294029]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11792824]
experiment: EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:7954792]
experiment: EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:7954792]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]
note: Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
codon start: 1
product: cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1
translation: MTPSTPPRSRGTRYLAQPSGNTSSSALMQGQKTPQKPSQNLVPVTPSTTKSFKNAPLLAPPNSNMGMTSPFNGLTSPQRSPFPKSSVKRTLFQFESHDNGTVREEQEPLGRVNRILFPTQQNVDIDAAEEEEEGEVLLPPSRPTSARQLHLSLERDEFDQTHRKKIIKDVPGTPSDKVITFELAKNWNNNSPKNDARSQESEDEEDIIINPVRVGKNPFASDELVTQEIRNERKRAMLRENPDIEDVITYVNKKGEVVEKRRLTDEEKRRFKPKALFQSRDQEH
SIO_010081: YLR079W
subclass of: SO_0000673
so part of: YLR079W
location: 286820..287674
location: region:286820-287674:1
so has part: feature:286820-287674:1:exon

NP_013180.1
type: Protein
SIO_000068: ncbiprotein

S000004069
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:286820-287674:1:exon

YLR080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMP46
locus tag: YLR080W
so part of: sequence
location: <287916..>289250
location: region:287916-289250:1
so has part: feature:287916-289250:1:exon
subclass of: SO_0000010

850769
type: Gene
SIO_000068: ncbigene

position:287916:1
position: 287916
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:289250:1
position: 289250
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287916-289250:1:exon

YLR080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMP46
locus tag: YLR080W
product: Emp46p
transcript id: NM_001181967.1
SIO_010081: YLR080W
subclass of: SO_0000673
so part of: YLR080W
location: <287916..>289250
location: region:287916-289250:1
so has part: feature:287916-289250:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:287916-289250:1:exon

YLR080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMP46
locus tag: YLR080W
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12134087]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030246 carbohydrate binding [PMID:16439369]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12134087]
experiment: EXISTENCE:physical interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:12857885]
note: Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication
codon start: 1
product: Emp46p
translation: MTTRKTASSLQLLGKITGTKAGTKQKKMNFINGLIWLYMCVWMVHGKVTQKDELKWNKGYSLPNLLEVTDQQKELSQWTLGDKVKLEEGRFVLTPGKNTKGSLWLKPEYSIKDAMTIEWTFRSFGFRGSTKGGLAFWLKQGNEGDSTELFGGSSKKFNGLMILLRLDDKLGESVTAYLNDGTKDLDIESSPYFASCLFQYQDSMVPSTLRLTYNPLDNHLLKLQMDNRVCFQTRKVKFMGSSPFRIGTSAINDASKESFEILKMKLYDGVIEDSLIPNVNPMGQPRVVTKVINSQTGEESFREKMPFSDKEESITSNELFEKMNKLEGKIMANDIDPLLRKMNKIVENERELIQRLRPLLDLKKTAISDDSFQDFLSMNANLDRLIKEQEKIRQDAKLYGKQTKGHDEIFSKISVWLALLIFIMITLAYYMFRINQDIKKVKLL
SIO_010081: YLR080W
subclass of: SO_0000673
so part of: YLR080W
location: 287916..289250
location: region:287916-289250:1
so has part: feature:287916-289250:1:exon

NP_013181.1
type: Protein
SIO_000068: ncbiprotein

S000004070
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:287916-289250:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1212; Late-firing chromosomal replication origin
so part of: sequence
location: 289315..289444
location: region:289315-289444:1
so has part: feature:289315-289444:1:region

S000118472
type: SGD
SIO_000068: sgd

position:289315:1
position: 289315
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:289444:1
position: 289444
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:289315-289444:1:region

YLR081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAL2
locus tag: YLR081W
so part of: sequence
location: <290212..>291936
location: region:290212-291936:1
so has part: feature:290212-291936:1:exon
subclass of: SO_0000010

850770
type: Gene
SIO_000068: ncbigene

position:290212:1
position: 290212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:291936:1
position: 291936
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290212-291936:1:exon

YLR081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAL2
locus tag: YLR081W
product: galactose permease GAL2
transcript id: NM_001181968.1
SIO_010081: YLR081W
subclass of: SO_0000673
so part of: YLR081W
location: <290212..>291936
location: region:290212-291936:1
so has part: feature:290212-291936:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:290212-291936:1:exon

YLR081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAL2
locus tag: YLR081W
experiment: EXISTENCE:direct assay:GO:0005355 glucose transmembrane transporter activity [PMID:12702270]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9045811]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:3082856]
experiment: EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:3082856]
experiment: EXISTENCE:mutant phenotype:GO:0015757 galactose transmembrane transport [PMID:3082856]
note: Galactose permease; required for utilization of galactose; also able to transport glucose
codon start: 1
product: galactose permease GAL2
translation: MAVEENNMPVVSQQPQAGEDVISSLSKDSHLSAQSQKYSNDELKAGESGSEGSQSVPIEIPKKPMSEYVTVSLLCLCVAFGGFMFGWDTGTISGFVVQTDFLRRFGMKHKDGTHYLSNVRTGLIVAIFNIGCAFGGIILSKGGDMYGRKKGLSIVVSVYIVGIIIQIASINKWYQYFIGRIISGLGVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTNYGTKSYSNSVQWRVPLGLCFAWSLFMIGALTLVPESPRYLCEVNKVEDAKRSIAKSNKVSPEDPAVQAELDLIMAGIEAEKLAGNASWGELFSTKTKVFQRLLMGVFVQMFQQLTGNNYFFYYGTVIFKSVGLDDSFETSIVIGVVNFASTFFSLWTVENLGHRKCLLLGAATMMACMVIYASVGVTRLYPHGKSQPSSKGAGNCMIVFTCFYIFCYATTWAPVAWVITAESFPLRVKSKCMALASASNWVWGFLIAFFTPFITSAINFYYGYVFMGCLVAMFFYVFFFVPETKGLSLEEIQELWEEGVLPWKSEGWIPSSRRGNNYDLEDLQHDDKPWYKAMLE
SIO_010081: YLR081W
subclass of: SO_0000673
so part of: YLR081W
location: 290212..291936
location: region:290212-291936:1
so has part: feature:290212-291936:1:exon

NP_013182.1
type: Protein
SIO_000068: ncbiprotein

S000004071
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:290212-291936:1:exon

YLR082C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRL2
locus tag: YLR082C
so part of: sequence
location: complement(<292394..>293572)
location: region:292394-293572:-1
so has part: feature:292394-293572:-1:exon
subclass of: SO_0000010

850771
type: Gene
SIO_000068: ncbigene

position:292394:-1
position: 292394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:293572:-1
position: 293572
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292394-293572:-1:exon

YLR082C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRL2
locus tag: YLR082C
product: Srl2p
transcript id: NM_001181969.1
SIO_010081: YLR082C
subclass of: SO_0000673
so part of: YLR082C
location: complement(<292394..>293572)
location: region:292394-293572:-1
so has part: feature:292394-293572:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292394-293572:-1:exon

YLR082C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRL2
locus tag: YLR082C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:9744871]
note: hypothetical protein; overexpression suppresses the lethality caused by a rad53 null mutation
codon start: 1
product: Srl2p
translation: MSNFKNFTLNSFEDYYGKPSETPKMEEEKLEVTNVNASSSKKVHKSKKSTSKYDQKNVFRNSMTGIAQILPTKPVKIIEQNIDFANPKSFDLLQSTHTICFNKRINTTNTKLNVETHTSSDIDNDILHVGAPTDLGGNSNDEAETRQLRKFRWSNNKEKSLCEKLTVIYWALLLHTTKRASKRRPILCHQMIAEFFNRVYKEKSRVPITSRYIRDNLVAWVTQGKELHEKGWVGDAKTGDLQEQFNIATVKLYESAEDGRLSIGKDKPFREENTGSDSLVRAEEDSTAVTNENGHISSEKNLKKDRRESIRNQILTLDLNDEDFFQNVMKVLSAIDEPELRQYVIVISELVSMEMDDGKTVREKLRDVELNINRLQVDIKEIKEMLVTLINK
SIO_010081: YLR082C
subclass of: SO_0000673
so part of: YLR082C
location: complement(292394..293572)
location: region:292394-293572:-1
so has part: feature:292394-293572:-1:exon

NP_013183.1
type: Protein
SIO_000068: ncbiprotein

S000004072
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292394-293572:-1:exon

YLR083C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TMN1
gene: EMP70
locus tag: YLR083C
gene synonym: TMN1
so part of: sequence
location: complement(<294091..>296094)
location: region:294091-296094:-1
so has part: feature:294091-296094:-1:exon
subclass of: SO_0000010

850772
type: Gene
SIO_000068: ncbigene

position:294091:-1
position: 294091
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296094:-1
position: 296094
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:294091-296094:-1:exon

YLR083C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TMN1
gene: EMP70
locus tag: YLR083C
gene synonym: TMN1
product: Emp70p
transcript id: NM_001181970.1
SIO_010081: YLR083C
subclass of: SO_0000673
so part of: YLR083C
location: complement(<294091..>296094)
location: region:294091-296094:-1
so has part: feature:294091-296094:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:294091-296094:-1:exon

YLR083C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TMN1
gene: EMP70
locus tag: YLR083C
gene synonym: TMN1
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20681974]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:8314797]
experiment: EXISTENCE:genetic interaction:GO:0006878 cellular copper ion homeostasis [PMID:20681974]
experiment: EXISTENCE:genetic interaction:GO:0007034 vacuolar transport [PMID:20526336]
experiment: EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:18178563]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18178563]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:20681974]
experiment: EXISTENCE:mutant phenotype:GO:0016197 endosomal transport [PMID:20526336]
note: Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication
codon start: 1
product: Emp70p
translation: MIYKMAHVQLLLLYFFVSTVKAFYLPGVAPTTYRENDNIPLLVNHLTPSMNYQHKDEDGNNVSGDKENFLYSYDYYYNRFHFCQPEKVEKQPESLGSVIFGDRIYNSPFQLNMLQEKECESLCKTVIPGDDAKFINKLIKNGFFQNWLIDGLPAAREVYDGRTKTSFYGAGFNLGFVQVTQGTDIEATPKGAETTDKDVELETRNDRNMVKTYELPYFANHFDIMIEYHDRGEGNYRVVGVIVEPVSIKRSSPGTCETTGSPLMLDEGNDNEVYFTYSVKFNESATSWATRWDKYLHVYDPSIQWFSLINFSLVVVLLSSVVIHSLLRALKSDFARYNELNLDDDFQEDSGWKLNHGDVFRSPSQSLTLSILVGSGVQLFLMVTCSIFFAALGFLSPSSRGSLATVMFILYALFGFVGSYTSMGIYKFFNGPYWKANLILTPLLVPGAILLIIIALNFFLMFVHSSGVIPASTLFFMVFLWFLFSIPLSFAGSLIARKRCHWDEHPTKTNQIARQIPFQPWYLKTIPATLIAGIFPFGSIAVELYFIYTSLWFNKIFYMFGFLFFSFLLLTLTSSLVTILITYHSLCLENWKWQWRGFIIGGAGCALYVFIHSILFTKFKLGGFTTIVLYVGYSSVISLLCCLVTGSIGFISSMLFVRKIYSSIKVD
SIO_010081: YLR083C
subclass of: SO_0000673
so part of: YLR083C
location: complement(294091..296094)
location: region:294091-296094:-1
so has part: feature:294091-296094:-1:exon

NP_013184.1
type: Protein
SIO_000068: ncbiprotein

S000004073
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:294091-296094:-1:exon

YLR084C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAX2
locus tag: YLR084C
so part of: sequence
location: complement(<296589..>300251)
location: region:296589-300251:-1
so has part: feature:296589-300251:-1:exon
subclass of: SO_0000010

850773
type: Gene
SIO_000068: ncbigene

position:296589:-1
position: 296589
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:300251:-1
position: 300251
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:296589-300251:-1:exon

YLR084C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAX2
locus tag: YLR084C
product: Rax2p
transcript id: NM_001181971.1
SIO_010081: YLR084C
subclass of: SO_0000673
so part of: YLR084C
location: complement(<296589..>300251)
location: region:296589-300251:-1
so has part: feature:296589-300251:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:296589-300251:-1:exon

YLR084C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAX2
locus tag: YLR084C
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:15356260|PMID:11110666|PMID:25416945]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15356260|PMID:11110666|PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0007121 bipolar cellular bud site selection [PMID:11110666]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:11110666]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:25416945]
note: Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated
codon start: 1
product: Rax2p
translation: MFVHRLWTLAFPFLVEISKASQLENIKSLLDIEDNVLPNLNISQNNSNAVQILGGVDALSFYEYTGQQNFTKEIGPETSSHGLVYYSNNTYIQLEDASDDTRIDKITPFGVDSFILSGSGTINNISVGNQILYNLSTLSMTPIFNQSLGAVQAVLADNSSIYFGGNFSYNNGSMTGYSALIWDSISNTTQLLPFGGFGENSSVNSIVKLNNDNILFAGQFYTLDDPSALISSSNNGTNSTSSLNATTLELGQRIPLRYASWDSQGSTTFASDSLVCPNTNEDAWLYPDTSGSLVCNLPYEVSPTKIRLYNSQRSDSEISVFQILTDPSSSIMNLTYLDPLSGELKNCGEFCPLYSRATLLSASQNVSSSMDMITFIDNNKTDVKWTSDFQDFAFVNELPVSSLKFVALNSYGGSVGLSGLELYQDTFSTYANDSLNEYGCSALTNDSSSSTLSSNDWYNGLTGESYIAAKYVPDQNEPIPRVKFYPNIIHPGHYTINMYTPGCLQDNTCSARGIVNVTMWNQQNNTIMKTYLIYQNNDNLKYDQIYSGYLDFSPEIVLEYVSGIYTTNTATVVVADQVNVITVSLDAFNTLSDSSNAKKETLLNGILQYQKSNFTSTRLNETKVGNTTLNLFPVKNYPKNSSLYADIYDNKLVIGGVSNRISIVDLNDDFEVTSSKNQTIQGDVHGITKTNQGLLIFGDILSSNNQSAVFLFNGSFENVFNQSRTVNSALNISLANNDFIVLDNDYVVNASSNALIRNSSSFSLSLWAAGNNGDGDVLFSGAVSHMQYGNLNGSVRFLNENEIEPLNLEGGIVPYLGAYLNESATAYAYEVDSLNKIYFSNEVYPSWNWSSGITQMLYADNQTLLAVSAGSSTTAELSIFDLRNLTMIANETLGSNARINALVNFEKNCSMLVGGDFQMTEPNCTGLCLYNYESKTWSTFLNNTIFGEITQLSFTNSSELIISGLFETKEYQSIRLGSFNLTNSTMIPLLSGSEGKLNSFTVTEDSIVAWNDTSLFIYRNQEWNITSLPGNASSISSVSAIYTDIESNTLNKRGINNVNNGSILLLNGNFNISQYGYLQSLLFDFQKWTPYFISETTNTSNYNPIIFINRDVSTEFNSQSPLANVNITVTSPQSTSSQPPSSSASSESKSKSKKKKIGRGFVVLIGLALALGTVSVLGIAGVILAYVFKDPEGDYKPIKPRIDENEMLDTVPPEKLMKFV
SIO_010081: YLR084C
subclass of: SO_0000673
so part of: YLR084C
location: complement(296589..300251)
location: region:296589-300251:-1
so has part: feature:296589-300251:-1:exon

NP_013185.1
type: Protein
SIO_000068: ncbiprotein

S000004074
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:296589-300251:-1:exon

YLR085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARP6
locus tag: YLR085C
so part of: sequence
location: complement(<300673..>301989)
location: region:300673-301989:-1
so has part: feature:300673-301989:-1:exon
subclass of: SO_0000010

850774
type: Gene
SIO_000068: ncbigene

position:300673:-1
position: 300673
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301989:-1
position: 301989
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:300673-301989:-1:exon

YLR085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARP6
locus tag: YLR085C
product: Arp6p
transcript id: NM_001181972.1
SIO_010081: YLR085C
subclass of: SO_0000673
so part of: YLR085C
location: complement(<300673..>301989)
location: region:300673-301989:-1
so has part: feature:300673-301989:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:300673-301989:-1:exon

YLR085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARP6
locus tag: YLR085C
experiment: EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608|PMID:16299513]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11011149]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]
experiment: EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16299513]
note: Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
codon start: 1
product: Arp6p
translation: METPPIVIDNGSYEIKFGPSTNKKPFRALNALAKDKFGTSYLSNHIKNIKDISSITFRRPHELGQLTLWELESCIWDYCLFNPSEFDGFDLKEGKGHHLVASESCMTLPELSKHADQVIFEEYEFDSLFKSPVAVFVPFTKSYKGEMRTISGKDEDIDIVRGNSDSTNSTSSESKNAQDSGSDYHDFQLVIDSGFNCTWIIPVLKGIPYYKAVKKLDIGGRFLTGLLKETLSFRHYNMMDETILVNNIKEQCLFVSPVSYFDSFKTKDKHALEYVLPDFQTSFLGYVRNPRKENVPLPEDAQIITLTDELFTIPETFFHPEISQITKPGIVEAILESLSMLPEIVRPLMVGNIVCTGGNFNLPNFAQRLAAELQRQLPTDWTCHVSVPEGDCALFGWEVMSQFAKTDSYRKARVTREEYYEHGPDWCTKHRFGYQNWI
SIO_010081: YLR085C
subclass of: SO_0000673
so part of: YLR085C
location: complement(300673..301989)
location: region:300673-301989:-1
so has part: feature:300673-301989:-1:exon

NP_013186.1
type: Protein
SIO_000068: ncbiprotein

S000004075
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:300673-301989:-1:exon

YLR086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMC4
locus tag: YLR086W
so part of: sequence
location: <302243..>306499
location: region:302243-306499:1
so has part: feature:302243-306499:1:exon
subclass of: SO_0000010

850775
type: Gene
SIO_000068: ncbigene

position:302243:1
position: 302243
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:306499:1
position: 306499
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302243-306499:1:exon

YLR086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMC4
locus tag: YLR086W
product: condensin subunit SMC4
transcript id: NM_001181973.1
SIO_010081: YLR086W
subclass of: SO_0000673
so part of: YLR086W
location: <302243..>306499
location: region:302243-306499:1
so has part: feature:302243-306499:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:302243-306499:1:exon

YLR086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMC4
locus tag: YLR086W
experiment: EXISTENCE:curator inference:GO:0007130 synaptonemal complex assembly [PMID:10811823]
experiment: EXISTENCE:curator inference:GO:0010032 meiotic chromosome condensation [PMID:10811823]
experiment: EXISTENCE:curator inference:GO:0051307 meiotic chromosome separation [PMID:10811823]
experiment: EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11864994]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12719426]
experiment: EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:10811823]
experiment: EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:10811823]
experiment: EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]
experiment: EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:10811823]
note: Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
codon start: 1
product: condensin subunit SMC4
translation: MSDSPLSKRQKRKSAQEPELSLDQGDAEEDSQVENRVNLSENTPEPDLPALEASYSKSYTPRKLVLSSGENRYAFSQPTNSTTTSLHVPNLQPPKTSSRGRDHKSYSQSPPRSPGRSPTRRLELLQLSPVKNSRVELQKIYDRHQSSSKQQSRLFINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGFRANKMRQDRLSDLIHKSEAFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPGLIITRKAFKNNSSKYYINEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYLEDIIGTANYKPLIEERMGQIENLNEVCLEKENRFEIVDREKNSLESGKETALEFLEKEKQLTLLRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQRKEIKDRISSCSSKEKTLVLERRELEGTRVSLEERTKNLVSKMEKAEKTLKSTKHSISEAENMLEELRGQQTEHETEIKDLTQLLEKERSILDDIKLSLKDKTKNISAEIIRHEKELEPWDLQLQEKESQIQLAESELSLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKDERSQGEKNFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGRLGDLGVIDDSFDVAISTACPRLDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRLRQFNLQPISTPENVPRLFDLVKPKNPKFSNAFYSVLRDTLVAQNLKQANNVAYGKKRFRVVTVDGKLIDISGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDKIERELSERENNFRVASDTVHEMEEELKKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAEMAYVKAVSDKAQLNVVMKNLERLRGEYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQNSKVESVCQKLDILVAKLKKVKSASKKSGGDVVKFQKLLQNSERDVELSSDELKVIEEQLKHTKLALAENDTNMNETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKGLNELSIRDVTHTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDAETSCDNYHPMNIDETSDEVSRGIPRLSEDELRELDVELIESKINELSYYVEETNVDIGVLEEYARRLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMGGNAELELVDSLDPFSEGVTFSVMPPKKSWRNITNLSGGEKTLSSLALVFALHKYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKNIDILNRT
SIO_010081: YLR086W
subclass of: SO_0000673
so part of: YLR086W
location: 302243..306499
location: region:302243-306499:1
so has part: feature:302243-306499:1:exon

NP_013187.1
type: Protein
SIO_000068: ncbiprotein

S000004076
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302243-306499:1:exon

YLR087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSF1
locus tag: YLR087C
so part of: sequence
location: complement(<306855..>315731)
location: region:306855-315731:-1
so has part: feature:306855-315731:-1:exon
subclass of: SO_0000010

850776
type: Gene
SIO_000068: ncbigene

position:306855:-1
position: 306855
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315731:-1
position: 315731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:306855-315731:-1:exon

YLR087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSF1
locus tag: YLR087C
product: Csf1p
transcript id: NM_001181974.1
SIO_010081: YLR087C
subclass of: SO_0000673
so part of: YLR087C
location: complement(<306855..>315731)
location: region:306855-315731:-1
so has part: feature:306855-315731:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:306855-315731:-1:exon

YLR087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSF1
locus tag: YLR087C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0006113 fermentation [PMID:10781556]
experiment: EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:19433630]
experiment: EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:35188676]
note: Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles; required for fermentation at low temperature; plays a role in phosphatidylethanolamine metabolism and maturation of secretory proteins; non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Csf1p
translation: MEAISQLRGVPLTHQKDFSWVFLVDWILTVVVCLTMIFYMGRIYAYLVSFILEWLLWKRAKIKINVETLRVSLLGGRIHFKNLSVIHKDYTISVLEGSLTWKYWLLNCRKAELIENNKSSSGKKAKLPCKISVECEGLEIFIYNRTVAYDNVINLLSKDERDKFEKYLNEHSFPEPFSDGSSADKLDEDLSESAYTTNSDASIVNDRDYQETDIGKHPKLLMFLPIELKFSRGSLLLGNKFTPSVMILSYESGKGIIDVLPPKERLDLYRNKTQMEFKNFEISIKQNIGYDDAIGLKFKIDRGKVSKLWKTFVRVFQIVTKPVVPKKTKKSAGTSDDNFYHKWKGLSLYKASAGDAKASDLDDVEFDLTNHEYAKFTSILKCPKVTIAYDVDVPGVVPHGAHPTIPDIDGPDVGNNGAPPDFALDVQIHGGSICYGPWAQRQVSHLQRVLSPVVSRTAKPIKKLPPGSRRIYTLFRMNISIMEDTTWRIPTRESSKDPEFLKHYKETNEEYRPFGWMDLRFCKDTYANFNISVCPTVQGFQNNFHVHFLETEIRSSVNHDILLKSKVFDIDGDIGYPLGWNSKAIWIINMKSEQLEAFLLREHITLVADTLSDFSAGDPTPYELFRPFVYKVNWEMEGYSIYLNVNDHNIVNNPLDFNENCYLSLHGDKLSIDVTVPRESILGTYTDMSYEISTPMFRMMLNTPPWNTLNEFMKHKEVGRAYDFTIKGSYLLYSELDIDNVDTLVIECNSKSTVLHCYGFVMRYLTNVKMNYFGEFFNFVTSEEYTGVLGAREVGDVTTKSSVADLASTVDSGYQNSSLKNESEDKGPMKRSDLKRTTNETDIWFTFSVWDGALILPETIYSFDPCIALHFAELVVDFRSCNYYMDIMAVLNGTSIKRHVSKQINEVFDFIRRNNGADEQEHGLLSDLTIHGHRMYGLPPTEPTYFCQWDINLGDLCIDSDIEFIKGFFNSFYKIGFGYNDLENILLYDTETINDMTSLTVHVEKIRIGLKDPVMKSQSVISAESILFTLIDFENEKYSQRIDVKIPKLTISLNCVMGDGVDTSFLKFETKLRFTNFEQYKDIDKKRSEQRRYITIHDSPYHRCPFLLPLFYQDSDTYQNLYGAIAPSSSIPTLPLPTLPDTIDYIIEDIVGEYATLLETTNPFKNIFAETPSTMEPSRASFSEDDNDEEADPSSFKPVAFTEDRNHERDNYVVDVSYILLDVDPLLFIFAKSLLEQLYSENMVQVLDDIEIGIVKRLSNLQEGITSISNIDIHIAYLNLIWQETGEEGFELYLDRIDYQMSEKSLEKNRTNKLLEVAALAKVKTVRVTVNQKKNPDLSEDRPPALSLGIEGFEVWSSTEDRQVNSLNLTSSDITIDESQMEWLFEYCSDQGNLIQEVCTSFNSIQNTRSNSKTELISKLTAASEYYQISHDPYVITKPAFIMRLSKGHVRENRSWKIITRLRHILTYLPDDWQSNIDEVLKEKKYTSAKDAKNIFMSVFSTWRNWEFSDVARSYIYGKLFTAENEKHKQNLIKKLLKCTMGSFYLTVYGEGYEVEHNFVVADANLVVDLTPPVTSLPSNREETIEITGRVGSVKGKFSDRLLKLQDLIPLIAAVGEDDKSDPKKELSKQFKMNTVLLVDKSELQLVMDQTKLMSRTVGGRVSLLWENLKDSTSQAGSLVIFSQKSEVWLKHTSVILGEAQLRDFSVLATTEAWSHKPTILINNQCADLHFRAMSSTEQLVTAITEIRESLMMIKERIKFKPKSKKKSQFVDQKINTVLSCYFSNVSSEVMPLSPFYIRHEAKQLDIYFNKFGSNEILLSIWDTDFFMTSHQTKEQYLRFSFGDIEIKGGISREGYSLINVDISISMIKLTFSEPRRIVNSFLQDEKLASQGINLLYSLKPLFFSSNLPKKEKQAPSIMINWTLDTSITYFGVLVPVASTYFVFELHMLLLSLTNTNNGMLPEETKVTGQFSIENILFLIKERSLPIGLSKLLDFSIKVS…
SIO_010081: YLR087C
subclass of: SO_0000673
so part of: YLR087C
location: complement(306855..315731)
location: region:306855-315731:-1
so has part: feature:306855-315731:-1:exon

NP_013188.1
type: Protein
SIO_000068: ncbiprotein

S000004077
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:306855-315731:-1:exon

YLR088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: END2
gene: GAA1
locus tag: YLR088W
gene synonym: END2
so part of: sequence
location: <316107..>317951
location: region:316107-317951:1
so has part: feature:316107-317951:1:exon
subclass of: SO_0000010

850777
type: Gene
SIO_000068: ncbigene

position:316107:1
position: 316107
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:317951:1
position: 317951
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316107-317951:1:exon

YLR088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: END2
gene: GAA1
locus tag: YLR088W
gene synonym: END2
product: GPI-anchor transamidase subunit GAA1
transcript id: NM_001181975.1
SIO_010081: YLR088W
subclass of: SO_0000673
so part of: YLR088W
location: <316107..>317951
location: region:316107-317951:1
so has part: feature:316107-317951:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316107-317951:1:exon

YLR088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: END2
gene: GAA1
locus tag: YLR088W
gene synonym: END2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:11598210]
experiment: EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:11598210|PMID:7730400]
note: Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature
codon start: 1
product: GPI-anchor transamidase subunit GAA1
translation: MALLEKLHRRIVDMGLVPRIIALLPVISMLCALFGFISIAILPMDGQYRRTYISENALMPSQAYSYFRESEWNILRGYRSQIKEMVNMTSMERNNLMGSWLQEFGTKTAIYENEQYGETLYGVMHAPRGDGTEAMVLAVPWFNSDDEFNIGGAALGVSLARFFSRWPVWSKNIIVVFSENPRAALRSWVEAYHTSLDLTGGSIEAAVVLDYSSTEDFFEYVEISYDGLNGELPNLDLVNIAISITEHEGMKVSLHGLPSDQLTNNNFWSRLKILCLGIRDWALSGVKKPHGNEAFSGWRIQSVTLKAHGNSGHDITTFGRIPEAMFRSINNLLEKFHQSFFFYLLLAPRQFVSISSYLPSAVALSIAFAISSLNAFINNAYANISLFSEYNLVALLVWFVSLVISFVVSQAFLLIPSSGLLMTISMASCFLPLILSRKIHISEPLSYRLKNVAFLYFSLVSTSLLMINFAMALLIGTLAFPMTFVKTIVESSSEHEVTTQSSNPIKTEPKDEIELVENHMDTTPATPQQQKQKLKNLVLLILTNPFISITLFGLFFDDEFHGFDIINKLVSAWLDLKCWSWFVLCIGWLPCWLLILASSFESKSVVVRSKEKQS
SIO_010081: YLR088W
subclass of: SO_0000673
so part of: YLR088W
location: 316107..317951
location: region:316107-317951:1
so has part: feature:316107-317951:1:exon

NP_013189.1
type: Protein
SIO_000068: ncbiprotein

S000004078
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316107-317951:1:exon

YLR089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALT1
locus tag: YLR089C
so part of: sequence
location: complement(<318237..>320015)
location: region:318237-320015:-1
so has part: feature:318237-320015:-1:exon
subclass of: SO_0000010

850778
type: Gene
SIO_000068: ncbigene

position:318237:-1
position: 318237
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:320015:-1
position: 320015
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318237-320015:-1:exon

YLR089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALT1
locus tag: YLR089C
product: alanine transaminase ALT1
transcript id: NM_001181976.1
SIO_010081: YLR089C
subclass of: SO_0000673
so part of: YLR089C
location: complement(<318237..>320015)
location: region:318237-320015:-1
so has part: feature:318237-320015:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:318237-320015:-1:exon

YLR089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALT1
locus tag: YLR089C
EC number: 2.6.1.2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0030170 pyridoxal phosphate binding [PMID:29867852]
experiment: EXISTENCE:mutant phenotype:GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity [PMID:19396236]
experiment: EXISTENCE:mutant phenotype:GO:0006523 alanine biosynthetic process [PMID:19396236]
experiment: EXISTENCE:mutant phenotype:GO:0006524 alanine catabolic process [PMID:19396236]
note: Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive
codon start: 1
product: alanine transaminase ALT1
translation: MLSLSAKNHFTVSNSITHVIKSYHIRTLTSSAEKMPHITTPFSTSASSTKLKAFRKVRPVLQRHSSSWIVAQNHRRSLSGQSSLNDLRHLNRFPHHTLKTSNNEFYPAEQLTLEDVNENVLKAKYAVRGAIPMRAEELKAQLEKDPQSLPFDRIINANIGNPQQLQQKPLTYYRQVLSLLQYPELLNQNEQQLVDSKLFKLDAIKRAKSLMEDIGGSVGAYSSSQGVEGIRKSVAEFITKRDEGEISYPEDIFLTAGASAAVNYLLSIFCRGPETGVLIPIPQYPLYTATLALNNSQALPYYLDENSGWSTNPEEIETVVKEAIQNEIKPTVLVVINPGNPTGAVLSPESIAQIFEVAAKYGTVVIADEVYQENIFPGTKFHSMKKILRHLQREHPGKFDNVQLASLHSTSKGVSGECGQRGGYMELTGFSHEMRQVILKLASISLCPVVTGQALVDLMVRPPVEGEESFESDQAERNSIHEKLITRAMTLYETFNSLEGIECQKPQGAMYLFPKIDLPFKAVQEARHLELTPDEFYCKKLLESTGICTVPGSGFGQEPGTYHLRTTFLAPGLEWIKKWESFHKEFFDQYRD
SIO_010081: YLR089C
subclass of: SO_0000673
so part of: YLR089C
location: complement(318237..320015)
location: region:318237-320015:-1
so has part: feature:318237-320015:-1:exon

NP_013190.1
type: Protein
SIO_000068: ncbiprotein

S000004079
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:318237-320015:-1:exon

YLR090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: XDJ1
locus tag: YLR090W
so part of: sequence
location: <320701..>322080
location: region:320701-322080:1
so has part: feature:320701-322080:1:exon
subclass of: SO_0000010

850779
type: Gene
SIO_000068: ncbigene

position:320701:1
position: 320701
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:322080:1
position: 322080
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:320701-322080:1:exon

YLR090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: XDJ1
locus tag: YLR090W
product: Xdj1p
transcript id: NM_001181977.1
SIO_010081: YLR090W
subclass of: SO_0000673
so part of: YLR090W
location: <320701..>322080
location: region:320701-322080:1
so has part: feature:320701-322080:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:320701-322080:1:exon

YLR090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: XDJ1
locus tag: YLR090W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23329686]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:23329686]
note: Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Xdj1p
translation: MSGSDRGDRLYDVLGVTRDATVQEIKTAYRKLALKHHPDKYVDQDSKEVNEIKFKEITAAYEILSDPEKKSHYDLYGDDNGAASSGGANGFGDEDFMNFFNNFFNNGSHDGNNFPGEYDAYEEGNSTSSKDIDIDISLTLKDLYMGKKLKFDLKRQVICIKCHGSGWKPKRKIHVTHDVECESCAGKGSKERLKRFGPGLVASQWVVCEKCNGKGKYTKRPKNPKNFCPDCAGLGLLSKKEIITVNVAPGHHFNDVITVKGMADEEIDKTTCGDLKFHLTEKQENLEQKQIFLKNFDDGAGEDLYTSITISLSEALTGFEKFLTKTFDDRLLTLSVKPGRVVRPGDTIKIANEGWPILDNPHGRCGDLYVFVHIEFPPDNWFNEKSELLAIKTNLPSSSSCASHATVNTEDDSNLTNNETISNFRIIHTDDLPEGIRPFKPEAQDSAHQKARSSYCCIQ
SIO_010081: YLR090W
subclass of: SO_0000673
so part of: YLR090W
location: 320701..322080
location: region:320701-322080:1
so has part: feature:320701-322080:1:exon

NP_013191.1
type: Protein
SIO_000068: ncbiprotein

S000004080
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:320701-322080:1:exon

YLR091W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRG5
gene: GEP5
locus tag: YLR091W
gene synonym: RRG5
so part of: sequence
location: <322297..>323178
location: region:322297-323178:1
so has part: feature:322297-323178:1:exon
subclass of: SO_0000010

850780
type: Gene
SIO_000068: ncbigene

position:322297:1
position: 322297
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:323178:1
position: 323178
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:322297-323178:1:exon

YLR091W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRG5
gene: GEP5
locus tag: YLR091W
gene synonym: RRG5
product: Gep5p
transcript id: NM_001181978.1
SIO_010081: YLR091W
subclass of: SO_0000673
so part of: YLR091W
location: <322297..>323178
location: region:322297-323178:1
so has part: feature:322297-323178:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:322297-323178:1:exon

YLR091W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRG5
gene: GEP5
locus tag: YLR091W
gene synonym: RRG5
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]
experiment: EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]
note: hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane
codon start: 1
product: Gep5p
translation: MASQVNALLLPVIESTPLHQITKVALTTTLTSKQSDYKFKEIAVPLTKSLQLYEKAQRRQDLRASLKALESIIYQTHFQWNNPLPRHAHLFQKHYHFLLTHWPFENHRDLVDSIAVNNGKLNSTSSRSVWLKADWITLFNVKNPWVQTPPSLMRLSGTDLDTFTPERIFLINSLGNHYKFLIANSHLSYNHKKYPSPGVQIPVRNALGEVSPAKQIAQLFARQLSHIYKSLFIENPPLSPENELALTAVFYDETVERRLRRLYMRACARAYTTTNADSTTEPLMFHCTRWEVD
SIO_010081: YLR091W
subclass of: SO_0000673
so part of: YLR091W
location: 322297..323178
location: region:322297-323178:1
so has part: feature:322297-323178:1:exon

NP_013192.1
type: Protein
SIO_000068: ncbiprotein

S000004081
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:322297-323178:1:exon

YLR092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUL2
locus tag: YLR092W
so part of: sequence
location: <323544..>326225
location: region:323544-326225:1
so has part: feature:323544-326225:1:exon
subclass of: SO_0000010

850781
type: Gene
SIO_000068: ncbigene

position:323544:1
position: 323544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326225:1
position: 326225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323544-326225:1:exon

YLR092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SUL2
locus tag: YLR092W
product: sulfate permease
transcript id: NM_001181979.1
SIO_010081: YLR092W
subclass of: SO_0000673
so part of: YLR092W
location: <323544..>326225
location: region:323544-326225:1
so has part: feature:323544-326225:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323544-326225:1:exon

YLR092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SUL2
locus tag: YLR092W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9055073]
experiment: EXISTENCE:mutant phenotype:GO:0008272 sulfate transport [PMID:9055073]
experiment: EXISTENCE:mutant phenotype:GO:0015116 sulfate transmembrane transporter activity [PMID:9055073]
note: High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
codon start: 1
product: sulfate permease
translation: MSREGYPNFEEVEIPDFQETNNTVPDLDDLELEYDQYKNNENNDTFNDKDLESNSVAKHNAVNSSKGVKGSKIDYFNPSDVSLYDNSVSQFEETTVSLKEYYDHSIRSHLTVKGACSYLKSVFPIINWLPHYNFSWFTADLIAGITIGCVLVPQSMSYAQVATLPAQYGLYSSFIGAYSYSFFATSKDVCIGPVAVMSLQTAKVIADVTAKYPDGDSAITGPVIATTLALLCGIISAAVGFLRLGFLVELISLNAVAGFMTGSAFNILWGQVPALMGYNSLVNTRAATYKVVIETLKHLPDTKLDAVFGLIPLFLLYVWKWWCGTYGPRLNDRYNSKNPRLHKIIKWTYFYAQASRNGIIIIVFTCIGWAITRGKSKSERPISILGSVPSGLKEVGVFHVPPGLMSKLGPNLPASIIVLLLEHIAISKSFGRINDYKVVPDQELIAIGVSNLLGTFFNAYPATGSFSRSALKAKCNVRTPLSGLFSGSCVLLALYCLTGAFFYIPKATLSAVIIHAVSDLLASYQTTWNFWKMNPLDFICFIVTVLITVFASIEDGIYFAMCWSCAMLILKVAFPAGKFLGRVEVAEVTDAYVRPDSDVVSYVSENNNGISTLEDGGEDDKESSTKYVTNSSKKIETNVQTKGFDSPSSSISQPRIKYHTKWIPFDHKYTRELNPDVQILPPPDGVLVYRLSESYTYLNCSRHYNIITEEVKKVTRRGQLIRHRKKSDRPWNDPGPWEAPAFLKNLKFWKKRENDPESMENAPSTSVDVERDDRPLLKILCLDFSQVAQTDATALQSLVDLRKAINQYADRQVEFHFVGIISPWVKRGLISRGFGTLNEEYSDESIVAGHTSYHVARVPQGEENPEKYSVYTASGTNLPFFHIDIPDFAKWDI
SIO_010081: YLR092W
subclass of: SO_0000673
so part of: YLR092W
location: 323544..326225
location: region:323544-326225:1
so has part: feature:323544-326225:1:exon

NP_013193.1
type: Protein
SIO_000068: ncbiprotein

S000004082
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323544-326225:1:exon

YLR093C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAM2
gene: NYV1
locus tag: YLR093C
gene synonym: MAM2
so part of: sequence
location: complement(<326513..>327415)
location: region:326513-327415:-1
so has part: feature:326513-327415:-1:exon
subclass of: SO_0000010

850782
type: Gene
SIO_000068: ncbigene

position:326513:-1
position: 326513
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:327415:-1
position: 327415
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326513-327415:-1:exon

YLR093C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAM2
gene: NYV1
locus tag: YLR093C
gene synonym: MAM2
product: Nyv1p
transcript id: NM_001181980.1
SIO_010081: YLR093C
subclass of: SO_0000673
so part of: YLR093C
location: complement(join(<326513..327258,327400..>327415))
location: region:326513-327415:-1
so has part: feature:327400-327415:-1:exon
so has part: feature:326513-327258:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:327400-327415:-1:exon

position:327400:-1
position: 327400
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:326513-327258:-1:exon

position:327258:-1
position: 327258
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR093C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAM2
gene: NYV1
locus tag: YLR093C
gene synonym: MAM2
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16855025|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:19805279]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9425154]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548|PMID:9685264]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]
note: v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway
codon start: 1
product: Nyv1p
translation: MKRFNVSYVEVIKNGETISSCFQPFQKNENYGTITSANEQITPVIFHNLIMDMVLPKVVPIKGNKVTKMSMNLIDGFDCFYSTDDHDPKTVYVCFTLVDMPKILPIRILSGLQEYESNATNELLSSHVGQILDSFHEELVEYRNQTLNSSGNGQSSNGNGQNTISDIGDATEDQIKDVIQIMNDNIDKFLERQERVSLLVDKTSQLNSSSNKFRRKAVNIKEIMWWQKVKNITLLTFTIILFVSAAFMFFYLW
SIO_010081: YLR093C
subclass of: SO_0000673
so part of: YLR093C
location: complement(join(326513..327258,327400..327415))
location: region:326513-327415:-1
so has part: feature:327400-327415:-1:exon
so has part: feature:326513-327258:-1:exon

NP_013194.2
type: Protein
SIO_000068: ncbiprotein

S000004083
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:327400-327415:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:326513-327258:-1:exon

YLR094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIS3
locus tag: YLR094C
so part of: sequence
location: complement(<327730..>329238)
location: region:327730-329238:-1
so has part: feature:327730-329238:-1:exon
subclass of: SO_0000010

850783
type: Gene
SIO_000068: ncbigene

position:327730:-1
position: 327730
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:329238:-1
position: 329238
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:327730-329238:-1:exon

YLR094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIS3
locus tag: YLR094C
product: Gis3p
transcript id: NM_001181981.1
SIO_010081: YLR094C
subclass of: SO_0000673
so part of: YLR094C
location: complement(<327730..>329238)
location: region:327730-329238:-1
so has part: feature:327730-329238:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:327730-329238:-1:exon

YLR094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIS3
locus tag: YLR094C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:10628841]
codon start: 1
product: Gis3p
translation: MLLDVNTNHTLMHDAHVHEHCLIKSIRDDGALHSWSDSSKVFYPKSFYATATNKKNNKLASASMNKTATSNRTVSDEIYFHSTKPQFDGQGSAERTRTLTKRNSFKRTRILKARDDSELLNENRSSLMTPSLSSVMSQVRKTNSAKTLSGECPIHEGHLTQSIKRKFSEEAQSDCSSLSSSKLHPLTDDIADAVDLQTPAIGDEVLAEPVVPKMKIININDLDLFDDWEVKDLVDIFPPVYERRPRSSSALSLVSASSDAKLRPTSVDFQIIDKKGGKTSRRKSRSKSTTENMIYENDLVELEQWPSASPSPETDGSIASSELLPNKRIRQKSLNTNFLKLYSIETSCKRKSILPEVEVDDHLLKQLTYSEIRSLEIKKEPNVSTNDIKLALITRKKLWSDMVHETRNDLFGDSTPWNLHFVATTSNTEPSQGRESASEHATADLKSSLVRVHSDVKPWFNNGGTMLKPCGKLNLGKVTNKTSAPTREIQYVVKGWCDSRFL
SIO_010081: YLR094C
subclass of: SO_0000673
so part of: YLR094C
location: complement(327730..329238)
location: region:327730-329238:-1
so has part: feature:327730-329238:-1:exon

NP_013195.1
type: Protein
SIO_000068: ncbiprotein

S000004084
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:327730-329238:-1:exon

YLR095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IOC2
locus tag: YLR095C
so part of: sequence
location: complement(<329677..>332115)
location: region:329677-332115:-1
so has part: feature:329677-332115:-1:exon
subclass of: SO_0000010

850784
type: Gene
SIO_000068: ncbigene

position:329677:-1
position: 329677
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332115:-1
position: 332115
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:329677-332115:-1:exon

YLR095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IOC2
locus tag: YLR095C
product: Ioc2p
transcript id: NM_001181982.1
SIO_010081: YLR095C
subclass of: SO_0000673
so part of: YLR095C
location: complement(<329677..>332115)
location: region:329677-332115:-1
so has part: feature:329677-332115:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:329677-332115:-1:exon

YLR095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IOC2
locus tag: YLR095C
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]
experiment: EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:12482963]
experiment: EXISTENCE:direct assay:GO:0036437 Isw1b complex [PMID:12482963]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12482963]
experiment: EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:12482963]
note: Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p
codon start: 1
product: Ioc2p
translation: MRTKRTRGTRNVGASMPAGAANADSEDWKEYVSEDIIAQLNKHQLPYSEILDEKIADLANHWHFQYVMAWLSNVCESYTTTTFNTDQYGGSSTKCLWKNIKFDEGVFVTDVFSKIDGKDSNYYNDEVDVDEGSQNLYDRIRLQLLHQLAGNKSGQLKDWNVIVNHHLQNSSAYSDLVTDLPFLELEIARQFDIIYSIIKLIEMKNMIFKNYLANNLHLFTFSEVILDDDNSGGEEMKSLFALPNVGVLVKKTIHRVKEGSSSQVSQTLNIPIKLQNCTIKESDPDIPDSVELIHLEYSHDIDAYLQSITIDYDVITTNWGSMLEYWSENKSSKAIDEFITNLIPVYAEHRLYSAKLLANREKERAIAELMTRRKRSSRLVAKEEENKKKDLESEWFEKLDEREQFIRHRNKLVSKEIKKIKDLLWNQLWQLYDQDYRDEKLTRRNELKDRSGSGTPFFETSLGREEDNPLNEIDIGVLDHGPNFQSSIIPVEPPIPGTVGPLQTGDVPELPSDFCITKEELDELANYGIFTPQQEPDNQDSVFQCPGEPELAPMIITEDTETDLFNNRPLICCDHCYRWQHWECQPPKIIELISSTTKSPQHTLSQRDFGVIIMGNSHGNRRSSRRPQSTLEPSTKSSRPTDKRKPLSECSTFICAWCIRDLELELRNIFVPELKIIRAKQRKQQEDRERRKKMKEEKKRLEELAKKRELTESVSPPVFNNAFANMSSSTTPSIAAYEKTNPAINPAPNVNAAHPIITYSQQTGSKTVPQAPQAPQTSQASIQPQQQQQQQQQQQPLHPKEQNFHFQFPPTN
SIO_010081: YLR095C
subclass of: SO_0000673
so part of: YLR095C
location: complement(329677..332115)
location: region:329677-332115:-1
so has part: feature:329677-332115:-1:exon

NP_013196.1
type: Protein
SIO_000068: ncbiprotein

S000004085
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:329677-332115:-1:exon

YLR096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KIN2
locus tag: YLR096W
so part of: sequence
location: <332590..>336033
location: region:332590-336033:1
so has part: feature:332590-336033:1:exon
subclass of: SO_0000010

850785
type: Gene
SIO_000068: ncbigene

position:332590:1
position: 332590
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:336033:1
position: 336033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:332590-336033:1:exon

YLR096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KIN2
locus tag: YLR096W
product: serine/threonine protein kinase KIN2
transcript id: NM_001181983.1
SIO_010081: YLR096W
subclass of: SO_0000673
so part of: YLR096W
location: <332590..>336033
location: region:332590-336033:1
so has part: feature:332590-336033:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:332590-336033:1:exon

YLR096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KIN2
locus tag: YLR096W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8203145]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8020610]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:27096577]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27096577]
experiment: EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]
experiment: EXISTENCE:genetic interaction:GO:1903896 positive regulation of IRE1-mediated unfolded protein response [PMID:25348718]
experiment: EXISTENCE:physical interaction:GO:0005886 plasma membrane [PMID:15563607]
experiment: EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]
note: S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members
codon start: 1
product: serine/threonine protein kinase KIN2
translation: MPNPNTADYLVNPNFRTSKGGSLSPTPEAFNDTRVAAPATLRMMGKQSGPRNDQQQAPLMPPADIKQGKEQAAQRQNDASRPNGAVELRQFHRRSLGDWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMNRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRLEFIDDIEDTRRSLIRLVTEKEYIQLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLLSIYHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEVVPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTSRKSSDIHTELNGVLKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQEPLPEREPPTYMSKSNEISIKVPKSHSRTISDYIPSARRYPSYVPNSVDVKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQINDNDNNNVNAVVDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAALPPSDMTNDNGFLGEANKERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKAPPGSMPSIDYPKSMFLKGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGFICVQQRPSIETAAVPVITTTGVGLDSGKAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSPNYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVKVRIVGLAGVHFKKVSGNTWLYKELASYILKELNL
SIO_010081: YLR096W
subclass of: SO_0000673
so part of: YLR096W
location: 332590..336033
location: region:332590-336033:1
so has part: feature:332590-336033:1:exon

NP_013197.1
type: Protein
SIO_000068: ncbiprotein

S000004086
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:332590-336033:1:exon

YLR097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HRT3
locus tag: YLR097C
so part of: sequence
location: complement(<336231..>337265)
location: region:336231-337265:-1
so has part: feature:336231-337265:-1:exon
subclass of: SO_0000010

850786
type: Gene
SIO_000068: ncbigene

position:336231:-1
position: 336231
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337265:-1
position: 337265
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:336231-337265:-1:exon

YLR097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HRT3
locus tag: YLR097C
product: SCF ubiquitin ligase complex subunit HRT3
transcript id: NM_001181984.1
SIO_010081: YLR097C
subclass of: SO_0000673
so part of: YLR097C
location: complement(<336231..>337265)
location: region:336231-337265:-1
so has part: feature:336231-337265:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:336231-337265:-1:exon

YLR097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HRT3
locus tag: YLR097C
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:10582239|PMID:14747994]
experiment: EXISTENCE:genetic interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10582239]
experiment: EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:17141224|PMID:14747994]
note: Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
codon start: 1
product: SCF ubiquitin ligase complex subunit HRT3
translation: MIVDYEKDPRAKEAIAIWEKGVLKEKDGSMSDAINFYRSALKIHDNVESLYRKKILDEWMLHKKLSGLSMTTDAPDEQNETGKDDLSVEENAELQPCWILEILPDDILLRIIKKVILMSGESWVNLSMTCSTFSKLCFHDSVPFKTFAKYIYSKQIYDKMAMDLNGITDINTFEKEIWRGDDYRMLRERPYIKFEGVYISVVNYVRYGSNAESSLSLLKPVHMITYYRYFRFYENGQCLRLLSTDEPSAVVKHFSKENKPRHSHMCYWSLGFDYDFGHLKITRSDEKYTFIEEFQIKNQGNKRYQRLKWLSSIVVDKEGNASNCSLRNEKSFFFSRVKSFKDPG
SIO_010081: YLR097C
subclass of: SO_0000673
so part of: YLR097C
location: complement(336231..337265)
location: region:336231-337265:-1
so has part: feature:336231-337265:-1:exon

NP_013198.1
type: Protein
SIO_000068: ncbiprotein

S000004087
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:336231-337265:-1:exon

YLR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SIL2
alternative label: SIL3
gene: CHA4
locus tag: YLR098C
gene synonym: SIL2; SIL3
so part of: sequence
location: complement(<337527..>339473)
location: region:337527-339473:-1
so has part: feature:337527-339473:-1:exon
subclass of: SO_0000010

850787
type: Gene
SIO_000068: ncbigene

position:337527:-1
position: 337527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339473:-1
position: 339473
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337527-339473:-1:exon

YLR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SIL2
alternative label: SIL3
gene: CHA4
locus tag: YLR098C
gene synonym: SIL2; SIL3
product: Cha4p
transcript id: NM_001181985.1
SIO_010081: YLR098C
subclass of: SO_0000673
so part of: YLR098C
location: complement(<337527..>339473)
location: region:337527-339473:-1
so has part: feature:337527-339473:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337527-339473:-1:exon

YLR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SIL2
alternative label: SIL3
gene: CHA4
locus tag: YLR098C
gene synonym: SIL2; SIL3
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:30520011]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:8889513]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0009063 amino acid catabolic process [PMID:8889513]
experiment: EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:8889513]
note: DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
codon start: 1
product: Cha4p
translation: MMLEPSPPPLTTTVTPSLPSSLKKSVTDNDQNNNNVPRKRKLACQNCRRRRRKCNMEKPCSNCIKFRTECVFTQQDLRNKRYSTTYVEALQSQIRSLKEQLQILSSSSSTIASNALSSLKNNSDHGDAPNEKILKYGETAQSALPSSESNDENESDAFTKKMPSESPPPVGTNSIYPSNSLSIIKKKTDGSTRYQQQQVSLKNLSRSPLILRSLSLFFKWLYPGHYLFIHRETFLSAFFGDTNTKSYYCSEELVFAIAALGSLISYKSETELFQQSEVFYQRAKTIVLKKIFQLEDSSLAESSSSSKLAIIQTLLCLAFYDIGSGENPMAWYLSGLAFRIAHEIGLHLNPEAWSNVYEDELSIMDFEVRSRIYWGCYIADHLIAILFGRSTSLRLSNSTVPETDELPEIETGIEEYIYDPKVILSTANPLKKLIVLSRITEIFASKIFSPNETLLQRSEYLAKFNLEVYNWRRDLPPELQWTKRSLMEMTDFNPTIAYVWFHYYIVLISYNKPFIYEIKQSRELVEGYVDELYYLLKVWKNKFKTFEKATIYMIYSAILAIQCMKSNLIKKDRKQDFLNFLSAPTLNYELARKFIENSEDALHNSETMDLLGTLSHGNDFALEYNFDFTLLNEIDMLIGGNTNDGLSK
SIO_010081: YLR098C
subclass of: SO_0000673
so part of: YLR098C
location: complement(337527..339473)
location: region:337527-339473:-1
so has part: feature:337527-339473:-1:exon

NP_013199.1
type: Protein
SIO_000068: ncbiprotein

S000004088
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337527-339473:-1:exon

YLR099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ICT1
locus tag: YLR099C
so part of: sequence
location: complement(<339744..>340928)
location: region:339744-340928:-1
so has part: feature:339744-340928:-1:exon
subclass of: SO_0000010

850788
type: Gene
SIO_000068: ncbigene

position:339744:-1
position: 339744
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340928:-1
position: 340928
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339744-340928:-1:exon

YLR099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ICT1
locus tag: YLR099C
product: lysophosphatidic acid acyltransferase ICT1
transcript id: NM_001181986.1
SIO_010081: YLR099C
subclass of: SO_0000673
so part of: YLR099C
location: complement(<339744..>340928)
location: region:339744-340928:-1
so has part: feature:339744-340928:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339744-340928:-1:exon

YLR099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ICT1
locus tag: YLR099C
EC number: 2.3.1.51
experiment: EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:18252723]
experiment: EXISTENCE:mutant phenotype:GO:0006654 phosphatidic acid biosynthetic process [PMID:18252723]
note: Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant
codon start: 1
product: lysophosphatidic acid acyltransferase ICT1
translation: MWTNTFKWCSKTEKETTTADAKVCASVQGLKALQQQIMDSTTVRGSVNNTMTPGGINQWHFHNKRANKVCTPTVLIHGYAASSMAFYRTFENLSDNIKDLYAIDLPANGASEAPALQVNKTKKIKSLRFKHIEDDVVIPVIEKRPPAEDIKSHLEQYESYFVDRIEQWRKDNKLRKINVVGHSFGGYISFKYALKYPDSIEKLCLISPLGVENSIHAITHKWEPNTTYPLTFTDPSSRYYTRKLNVPRFIFENQLNVLKWMGPIGSKLCSNYISTAYVKVPDQIYKDYLLHSFVGKNQTVQPQTIKVFTHLFERNLIARDPIINNVRFLNPATPVMFMYGEHDWMDKYAGYLTTESMLKNKAKASYVEVPDAGHNLFLDNPQHFASSLVSFLSK
SIO_010081: YLR099C
subclass of: SO_0000673
so part of: YLR099C
location: complement(339744..340928)
location: region:339744-340928:-1
so has part: feature:339744-340928:-1:exon

NP_013200.1
type: Protein
SIO_000068: ncbiprotein

S000004089
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339744-340928:-1:exon

YLR099W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIM2
locus tag: YLR099W-A
so part of: sequence
location: <341325..>341588
location: region:341325-341588:1
so has part: feature:341325-341588:1:exon
subclass of: SO_0000010

850789
type: Gene
SIO_000068: ncbigene

position:341325:1
position: 341325
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:341588:1
position: 341588
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341325-341588:1:exon

YLR099W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIM2
locus tag: YLR099W-A
product: Mim2p
transcript id: NM_001184484.1
SIO_010081: YLR099W-A
subclass of: SO_0000673
so part of: YLR099W-A
location: <341325..>341588
location: region:341325-341588:1
so has part: feature:341325-341588:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341325-341588:1:exon

YLR099W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIM2
locus tag: YLR099W-A
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:22467864]
experiment: EXISTENCE:genetic interaction:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]
experiment: EXISTENCE:genetic interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:22467864]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]
experiment: EXISTENCE:physical interaction:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]
experiment: EXISTENCE:physical interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:22467864]
note: Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p and functions as cation-selective channel for translocation of positively charged precursor segments; not essential in W303 strain background
codon start: 1
product: Mim2p
translation: MADSEDTSVILQGIDTINSVEGLEEDGYLSDEDTSLSNELADAQRQWEESLQQLNKLLNWVLLPLLGKYIGRRMAKTLWSRFIEHFV
SIO_010081: YLR099W-A
subclass of: SO_0000673
so part of: YLR099W-A
location: 341325..341588
location: region:341325-341588:1
so has part: feature:341325-341588:1:exon

NP_076901.1
type: Protein
SIO_000068: ncbiprotein

S000007618
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341325-341588:1:exon

YLR100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG27
locus tag: YLR100W
so part of: sequence
location: <341810..>342853
location: region:341810-342853:1
so has part: feature:341810-342853:1:exon
subclass of: SO_0000010

850790
type: Gene
SIO_000068: ncbigene

position:341810:1
position: 341810
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:342853:1
position: 342853
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341810-342853:1:exon

YLR100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG27
locus tag: YLR100W
product: 3-keto-steroid reductase
transcript id: NM_001181987.1
SIO_010081: YLR100W
subclass of: SO_0000673
so part of: YLR100W
location: <341810..>342853
location: region:341810-342853:1
so has part: feature:341810-342853:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341810-342853:1:exon

YLR100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG27
locus tag: YLR100W
EC number: 1.1.1.270
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11279045|PMID:26928762|PMID:12119386]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]
experiment: EXISTENCE:mutant phenotype:GO:0000253 3-keto sterol reductase activity [PMID:10535978]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:10535978]
note: 3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7
codon start: 1
product: 3-keto-steroid reductase
translation: MNRKVAIVTGTNSNLGLNIVFRLIETEDTNVRLTIVVTSRTLPRVQEVINQIKDFYNKSGRVEDLEIDFDYLLVDFTNMVSVLNAYYDINKKYRAINYLFVNAAQGIFDGIDWIGAVKEVFTNPLEAVTNPTYKIQLVGVKSKDDMGLIFQANVFGPYYFISKILPQLTRGKAYIVWISSIMSDPKYLSLNDIELLKTNASYEGSKRLVDLLHLATYKDLKKLGINQYVVQPGIFTSHSFSEYLNFFTYFGMLCLFYLARLLGSPWHNIDGYKAANAPVYVTRLANPNFEKQDVKYGSATSRDGMPYIKTQEIDPTGMSDVFAYIQKKKLEWDEKLKDQIVETRTPI
SIO_010081: YLR100W
subclass of: SO_0000673
so part of: YLR100W
location: 341810..342853
location: region:341810-342853:1
so has part: feature:341810-342853:1:exon

NP_013201.1
type: Protein
SIO_000068: ncbiprotein

S000004090
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341810-342853:1:exon

YLR102C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APC9
locus tag: YLR102C
so part of: sequence
location: complement(<342970..>343767)
location: region:342970-343767:-1
so has part: feature:342970-343767:-1:exon
subclass of: SO_0000010

850792
type: Gene
SIO_000068: ncbigene

position:342970:-1
position: 342970
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343767:-1
position: 343767
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342970-343767:-1:exon

YLR102C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APC9
locus tag: YLR102C
product: anaphase promoting complex subunit 9
transcript id: NM_001181989.1
SIO_010081: YLR102C
subclass of: SO_0000673
so part of: YLR102C
location: complement(<342970..>343767)
location: region:342970-343767:-1
so has part: feature:342970-343767:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342970-343767:-1:exon

YLR102C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APC9
locus tag: YLR102C
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:12574115]
experiment: EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:12399376]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:12574115]
note: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
codon start: 1
product: anaphase promoting complex subunit 9
translation: MNQNGDKNEGKLFQLPSLPPWKTPRFNKANFNNFTTPLRKRSTRVINDDSMPITGEVLEERTADDLYGINMDVDEVDYLNTLSHIEEEKQYDYSPFCERNTLRESRIDSFLKAERAAHCLVFHKVGHLDGIDSYRPDIDIMCGEEANKYDSANPEGNGSMLLESVPGCNKEDLERLSRREFVTNSKPNMRRLDDIINHETNALKSFWNDSGLVNSLQSHHLHEEYLLLQEELKNVYKIKCHDRVPIESLRDKCRRHYSNEDSSFL
SIO_010081: YLR102C
subclass of: SO_0000673
so part of: YLR102C
location: complement(342970..343767)
location: region:342970-343767:-1
so has part: feature:342970-343767:-1:exon

NP_013203.1
type: Protein
SIO_000068: ncbiprotein

S000004092
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342970-343767:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1212.5; Strong autonomously replicating sequence
so part of: sequence
location: 343577..344032
location: region:343577-344032:1
so has part: feature:343577-344032:1:region

S000178135
type: SGD
SIO_000068: sgd

position:343577:1
position: 343577
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:344032:1
position: 344032
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:343577-344032:1:region

YLR103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLD4
gene: CDC45
locus tag: YLR103C
gene synonym: SLD4
so part of: sequence
location: complement(<343989..>345941)
location: region:343989-345941:-1
so has part: feature:343989-345941:-1:exon
subclass of: SO_0000010

850793
type: Gene
SIO_000068: ncbigene

position:343989:-1
position: 343989
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345941:-1
position: 345941
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:343989-345941:-1:exon

YLR103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLD4
gene: CDC45
locus tag: YLR103C
gene synonym: SLD4
product: DNA replication initiation factor CDC45
transcript id: NM_001181990.1
SIO_010081: YLR103C
subclass of: SO_0000673
so part of: YLR103C
location: complement(<343989..>345941)
location: region:343989-345941:-1
so has part: feature:343989-345941:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:343989-345941:-1:exon

YLR103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLD4
gene: CDC45
locus tag: YLR103C
gene synonym: SLD4
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:15494305|PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12019222]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:23382391]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8901577]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9335335|PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]
experiment: EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]
experiment: EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:2044962]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:23382391]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:2044962]
note: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
codon start: 1
product: DNA replication initiation factor CDC45
translation: MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL
SIO_010081: YLR103C
subclass of: SO_0000673
so part of: YLR103C
location: complement(343989..345941)
location: region:343989-345941:-1
so has part: feature:343989-345941:-1:exon

NP_013204.1
type: Protein
SIO_000068: ncbiprotein

S000004093
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:343989-345941:-1:exon

YLR104W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LCL2
locus tag: YLR104W
so part of: sequence
location: <346585..>346980
location: region:346585-346980:1
so has part: feature:346585-346980:1:exon
subclass of: SO_0000010

850794
type: Gene
SIO_000068: ncbigene

position:346585:1
position: 346585
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346980:1
position: 346980
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346585-346980:1:exon

YLR104W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LCL2
locus tag: YLR104W
product: Lcl2p
transcript id: NM_001181991.1
SIO_010081: YLR104W
subclass of: SO_0000673
so part of: YLR104W
location: <346585..>346980
location: region:346585-346980:1
so has part: feature:346585-346980:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346585-346980:1:exon

YLR104W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LCL2
locus tag: YLR104W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:19325107]
note: hypothetical protein; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole
codon start: 1
product: Lcl2p
translation: MSQSRWSIVLIFALFIFGSTGVNAFFNFGHHQQQQQQQQQSYEDQVLNNPCDGYLCPDTLTCVAQQKDCPCPFPKSQLKCVLPDNKFVCISKPATHNEKFRAIYDDPVKGPKAKNKGFRDCGWVSDAYKNH
SIO_010081: YLR104W
subclass of: SO_0000673
so part of: YLR104W
location: 346585..346980
location: region:346585-346980:1
so has part: feature:346585-346980:1:exon

NP_013205.1
type: Protein
SIO_000068: ncbiprotein

S000004094
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346585-346980:1:exon

YLR105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEN2
locus tag: YLR105C
so part of: sequence
location: complement(<347047..>348180)
location: region:347047-348180:-1
so has part: feature:347047-348180:-1:exon
subclass of: SO_0000010

850795
type: Gene
SIO_000068: ncbigene

position:347047:-1
position: 347047
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:348180:-1
position: 348180
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347047-348180:-1:exon

YLR105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEN2
locus tag: YLR105C
product: tRNA splicing endonuclease subunit SEN2
transcript id: NM_001181992.1
SIO_010081: YLR105C
subclass of: SO_0000673
so part of: YLR105C
location: complement(<347047..>348180)
location: region:347047-348180:-1
so has part: feature:347047-348180:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:347047-348180:-1:exon

YLR105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEN2
locus tag: YLR105C
EC number: 4.6.1.16
experiment: EXISTENCE:direct assay:GO:0000213 tRNA-intron endonuclease activity [PMID:9200603]
experiment: EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]
experiment: EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:12925762]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:mutant phenotype:GO:0000213 tRNA-intron endonuclease activity [PMID:2182322]
experiment: EXISTENCE:mutant phenotype:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:2182322]
experiment: EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:12925762]
experiment: EXISTENCE:mutant phenotype:GO:0098787 mRNA cleavage involved in mRNA processing [PMID:25971974]
note: Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; localizes to the peroxisome in a Pex5p-dependent manner in oleate
codon start: 1
product: tRNA splicing endonuclease subunit SEN2
translation: MSKGRVNQKRYKYPLPIHPVDDLPELILHNPLSWLYWAYRYYKSTNALNDKVHVDFIGDTTLHITVQDDKQMLYLWNNGFFGTGQFSRSEPTWKARTEARLGLNDTPLHNRGGTKSNTETEMTLEKVTQQRRLQRLEFKKERAKLERELLELRKKGGHIDEENILLEKQRESLRKFKLKQTEDVGIVAQQQDISESNLRDEDNNLLDENGDLLPLESLELMPVEAMFLTFALPVLDISPACLAGKLFQFDAKYKDIHSFVRSYVIYHHYRSHGWCVRSGIKFGCDYLLYKRGPPFQHAEFCVMGLDHDVSKDYTWYSSIARVVGGAKKTFVLCYVERLISEQEAIALWKSNNFTKLFNSFQVGEVLYKRWVPGRNRD
SIO_010081: YLR105C
subclass of: SO_0000673
so part of: YLR105C
location: complement(347047..348180)
location: region:347047-348180:-1
so has part: feature:347047-348180:-1:exon

NP_013206.1
type: Protein
SIO_000068: ncbiprotein

S000004095
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:347047-348180:-1:exon

YNCL0005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR79
locus tag: YNCL0005C
so part of: sequence
location: complement(348427..348510)
location: region:348427-348510:-1
so has part: feature:348427-348510:-1:exon
subclass of: SO_0000578

9164937
type: Gene
SIO_000068: ncbigene

position:348427:-1
position: 348427
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:348510:-1
position: 348510
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:348427-348510:-1:exon

YNCL0005C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR79
locus tag: YNCL0005C
product: SNR79
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position C1007
transcript id: NR_132205.1
SIO_010081: YNCL0005C
subclass of: SO_0000673
so part of: YNCL0005C
location: complement(348427..348510)
location: region:348427-348510:-1
so has part: feature:348427-348510:-1:exon

S000007313
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:348427-348510:-1:exon

YLR106C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MDN1
gene: REA1
locus tag: YLR106C
gene synonym: MDN1
so part of: sequence
location: complement(<349006..>363738)
location: region:349006-363738:-1
so has part: feature:349006-363738:-1:exon
subclass of: SO_0000010

850796
type: Gene
SIO_000068: ncbigene

position:349006:-1
position: 349006
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:363738:-1
position: 363738
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349006-363738:-1:exon

YLR106C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MDN1
gene: REA1
locus tag: YLR106C
gene synonym: MDN1
product: AAA family ATPase midasin
transcript id: NM_001181993.1
SIO_010081: YLR106C
subclass of: SO_0000673
so part of: YLR106C
location: complement(<349006..>363738)
location: region:349006-363738:-1
so has part: feature:349006-363738:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349006-363738:-1:exon

YLR106C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MDN1
gene: REA1
locus tag: YLR106C
gene synonym: MDN1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12102729]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:30460895]
experiment: EXISTENCE:direct assay:GO:0110136 protein-RNA complex remodeling [PMID:20542003]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:30460895]
experiment: EXISTENCE:mutant phenotype:GO:0110136 protein-RNA complex remodeling [PMID:20542003|PMID:24240281]
experiment: EXISTENCE:mutant phenotype:GO:2000200 regulation of ribosomal subunit export from nucleus [PMID:24240281]
note: Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain
codon start: 1
product: AAA family ATPase midasin
translation: MSQDRILLDLDVVNQRLILFNSAFPSDAIEAPFHFSNKESTSENLDNLAGTILHSRSITGHVFLYKHIFLEIVARWIKDSKKKDYVLVIEKLASIITIFPVAMPLIEDYLDKENDHFITILQNPSTQKDSDMFKILLAYYRLLYHNKEVFARFIQPDILYQLVDLLTKEQENQVVIFLALKVLSLYLDMGEKTLNDMLDTYIKSRDSLLGHFEGDSGIDYSFLELNEAKRCANFSKLPSVPECFTIEKKSSYFIIEPQDLSTKVASICGVIVPKVHTIHDKVFYPLTFVPTHKTVSSLRQLGRKIQNSTPIMLIGKAGSGKTFLINELSKYMGCHDSIVKIHLGEQTDAKLLIGTYTSGDKPGTFEWRAGVLATAVKEGRWVLIEDIDKAPTDVLSILLSLLEKRELTIPSRGETVKAANGFQLISTVRINEDHQKDSSNKIYNLNMIGMRIWNVIELEEPSEEDLTHILAQKFPILTNLIPKLIDSYKNVKSIYMNTKFISLNKGAHTRVVSVRDLIKLCERLDILFKNNGINKPDQLIQSSVYDSIFSEAADCFAGAIGEFKALEPIIQAIGESLDIASSRISLFLTQHVPTLENLDDSIKIGRAVLLKEKLNIQKKSMNSTLFAFTNHSLRLMEQISVCIQMTEPVLLVGETGTGKTTVVQQLAKMLAKKLTVINVSQQTETGDLLGGYKPVNSKTVAVPIQENFETLFNATFSLKKNEKFHKMLHRCFNKNQWKNVVKLWNEAYKMAQSILKITNTENENENAKKKKRRLNTHEKKLLLDKWADFNDSVKKFEAQSSSIENSFVFNFVEGSLVKTIRAGEWLLLDEVNLATADTLESISDLLTEPDSRSILLSEKGDAEPIKAHPDFRIFACMNPATDVGKRDLPMGIRSRFTEIYVHSPERDITDLLSIIDKYIGKYSVSDEWVGNDIAELYLEAKKLSDNNTIVDGSNQKPHFSIRTLTRTLLYVTDIIHIYGLRRSLYDGFCMSFLTLLDQKSEAILKPVIEKFTLGRLKNVKSIMSQTPPSPGPDYVQFKHYWMKKGPNTIQEQAHYIITPFVEKNMMNLVRATSGKRFPVLIQGPTSSGKTSMIKYLADITGHKFVRINNHEHTDLQEYLGTYVTDDTGKLSFKEGVLVEALRKGYWIVLDELNLAPTDVLEALNRLLDDNRELFIPETQEVVHPHPDFLLFATQNPPGIYGGRKILSRAFRNRFLELHFDDIPQDELEIILRERCQIAPSYAKKIVEVYRQLSIERSASRLFEQKNSFATLRDLFRWALRDAVGYEQLAASGYMLLAERCRTPQEKVTVKKTLEKVMKVKLDMDQYYASLEDKSLEAIGSVTWTKGMRRLSVLVSSCLKNKEPVLLVGETGCGKTTICQLLAQFMGRELITLNAHQNTETGDILGAQRPVRNRSEIQYKLIKSLKTALNIANDQDVDLKELLQLYSKSDNKNIAEDVQLEIQKLRDSLNVLFEWSDGPLIQAMRTGNFFLLDEISLADDSVLERLNSVLEPERSLLLAEQGSSDSLVTASENFQFFATMNPGGDYGKKELSPALRNRFTEIWVPSMEDFNDVNMIVSSRLLEDLKDLANPIVKFSEWFGKKLGGGNATSGVISLRDILAWVEFINKVFPKIQNKSTALIQGASMVFIDALGTNNTAYLAENENDLKSLRTECIIQLLKLCGDDLELQQIETNEIIVTQDELQVGMFKIPRFPDAQSSSFNLTAPTTASNLVRVVRAMQVHKPILLEGSPGVGKTSLITALANITGNKLTRINLSEQTDLVDLFGADAPGERSGEFLWHDAPFLRAMKKGEWVLLDEMNLASQSVLEGLNACLDHRGEAYIPELDISFSCHPNFLVFAAQNPQYQGGGRKGLPKSFVNRFSVVFIDMLTSDDLLLIAKHLYPSIEPDIIAKMIKLMSTLEDQVCKRKLWGNSGSPWEFNLRDTLRWLKLLNQYSICEDVDVFDFVDIIVKQRFRTISDKNKAQLLIEDIFGKFSTKENFFK…
SIO_010081: YLR106C
subclass of: SO_0000673
so part of: YLR106C
location: complement(349006..363738)
location: region:349006-363738:-1
so has part: feature:349006-363738:-1:exon

NP_013207.1
type: Protein
SIO_000068: ncbiprotein

S000004096
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349006-363738:-1:exon

YLR107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: REX3
locus tag: YLR107W
so part of: sequence
location: <364116..>365330
location: region:364116-365330:1
so has part: feature:364116-365330:1:exon
subclass of: SO_0000010

850797
type: Gene
SIO_000068: ncbigene

position:364116:1
position: 364116
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:365330:1
position: 365330
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364116-365330:1:exon

YLR107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: REX3
locus tag: YLR107W
product: RNA exonuclease
transcript id: NM_001181994.1
SIO_010081: YLR107W
subclass of: SO_0000673
so part of: YLR107W
location: <364116..>365330
location: region:364116-365330:1
so has part: feature:364116-365330:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:364116-365330:1:exon

YLR107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: REX3
locus tag: YLR107W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10716935]
experiment: EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10716935]
experiment: EXISTENCE:mutant phenotype:GO:0000175 3'-5'-exoribonuclease activity [PMID:10716935]
experiment: EXISTENCE:mutant phenotype:GO:0043628 regulatory ncRNA 3'-end processing [PMID:10716935]
note: RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
codon start: 1
product: RNA exonuclease
translation: MGSLLRPVDLVNQPLGFQERYKILQKLFKQLQKAYAHTKGTNIDLERLATRLEVHVAKNSLSGQSYKFNMSILLRDVLKYKGDLSKIKINGRPLKGAKPHLSSIGNANSITTKSKAMEALKALILDSKVLEKNGYIVKEMQNKTNDDNSTQLYAPCLRCSSNFKKTDIMEKTLCRYHPLKRIYNRDTKNHQYPCCGETTDSVSFLRLGCKTFFHHVFRGESYDELCKISKFSSTDDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFFTGKTLFDHVIQPIGDIVDLNSDFSGVHEIDRTNCPTYKEALDVFLSENLINKNSILIGHGLENDLNVMRLFHNKVIDTAILYSRTKFKVSLKNLAFEVLSRKIQNGEHDSSQDAIATMDVVKVKIGISPSQNKWEK
SIO_010081: YLR107W
subclass of: SO_0000673
so part of: YLR107W
location: 364116..365330
location: region:364116-365330:1
so has part: feature:364116-365330:1:exon

NP_013208.1
type: Protein
SIO_000068: ncbiprotein

S000004097
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:364116-365330:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(365810..366144)
location: region:365810-366144:-1
so has part: feature:365810-366144:-1:region

S000007067
type: SGD
SIO_000068: sgd

position:365810:-1
position: 365810
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:366144:-1
position: 366144
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:365810-366144:-1:region

YNCL0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR6
locus tag: YNCL0006W
so part of: sequence
location: 366235..366346
location: region:366235-366346:1
so has part: feature:366235-366346:1:exon
subclass of: SO_0000623

9164922
type: Gene
SIO_000068: ncbigene

position:366235:1
position: 366235
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:366346:1
position: 366346
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366235-366346:1:exon

YNCL0006W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snRNA
gene: SNR6
locus tag: YNCL0006W
product: SNR6
experiment: EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0010501 RNA secondary structure unwinding [PMID:27484481]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:22408182]
experiment: EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:17925343]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:24196718]
experiment: EXISTENCE:physical interaction:GO:0017069 snRNA binding [PMID:2440583]
note: U6 spliceosomal RNA (U6 snRNA); mediates catalysis of pre-mRNA splicing by the spliceosome; interacts with U4; homology to U6 snRNA, interacts with snr14
transcript id: NR_132206.1
SIO_010081: YNCL0006W
subclass of: SO_0000673
so part of: YNCL0006W
location: 366235..366346
location: region:366235-366346:1
so has part: feature:366235-366346:1:exon

S000006494
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366235-366346:1:exon

YLR108C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR108C
so part of: sequence
location: complement(<366667..>368124)
location: region:366667-368124:-1
so has part: feature:366667-368124:-1:exon
subclass of: SO_0000010

850798
type: Gene
SIO_000068: ncbigene

position:366667:-1
position: 366667
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:368124:-1
position: 368124
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366667-368124:-1:exon

YLR108C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR108C
product: uncharacterized protein
transcript id: NM_001181995.1
SIO_010081: YLR108C
subclass of: SO_0000673
so part of: YLR108C
location: complement(<366667..>368124)
location: region:366667-368124:-1
so has part: feature:366667-368124:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366667-368124:-1:exon

YLR108C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR108C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MSGQKGEIVVYTKELETTPELLPNHEVFKIRIGQKLFEISGATLNSDAPNFFTQFFNTHDKNTILFVDRSEDVFIIIYRHLQGYFPDIKNEVQFTCLFADALYFQLPKLVKLIKEYDYHFTNIGGVPFKVPKSLFHEEGNRLNYFETISRISYEEIEKWESNKKPGFPPLLPPSYIARSPEFFRDILSLLGGSKLELSEERTASLIKECRYYRLNRLEQELVRAKIIYNPLTNCQEVCIALDSVSKKGVTIERLTSLHTGNQSLAVSSCLNGTEGEKAATGFHKTETDSGNNDEYEPPTKKVKHCIERHWSMLKYQRPYIDTVSHDLIFQLHSNQCKIIFNKKNKTVHVDLSREAAVLFENKFSDVLLENPDFKIDLSEYKVKLRDSQMQVESHLIIPACVSICDLTVNGAKCCNIFSLVNDSKCKGRVLDCTNLKVLNCVHGLKLHLSKSMWKLGTNNGRIILVAVKAETFSGTKEYCKMIDFL
SIO_010081: YLR108C
subclass of: SO_0000673
so part of: YLR108C
location: complement(366667..368124)
location: region:366667-368124:-1
so has part: feature:366667-368124:-1:exon

NP_013209.1
type: Protein
SIO_000068: ncbiprotein

S000004098
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366667-368124:-1:exon

YLR109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AHP1
locus tag: YLR109W
so part of: sequence
location: <368781..>369311
location: region:368781-369311:1
so has part: feature:368781-369311:1:exon
subclass of: SO_0000010

850799
type: Gene
SIO_000068: ncbigene

position:368781:1
position: 368781
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:369311:1
position: 369311
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368781-369311:1:exon

YLR109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AHP1
locus tag: YLR109W
product: thioredoxin peroxidase AHP1
transcript id: NM_001181996.1
SIO_010081: YLR109W
subclass of: SO_0000673
so part of: YLR109W
location: <368781..>369311
location: region:368781-369311:1
so has part: feature:368781-369311:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368781-369311:1:exon

YLR109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AHP1
locus tag: YLR109W
EC number: 1.11.1.24
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10681558]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]
experiment: EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:10681558]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]
experiment: EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]
experiment: EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:12270680]
experiment: EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:10681558]
note: Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
codon start: 1
product: thioredoxin peroxidase AHP1
translation: MSDLVNKKFPAGDYKFQYIAISQSDADSESCKMPQTVEWSKLISENKKVIITGAPAAFSPTCTVSHIPGYINYLDELVKEKEVDQVIVVTVDNPFANQAWAKSLGVKDTTHIKFASDPGCAFTKSIGFELAVGDGVYWSGRWAMVVENGIVTYAAKETNPGTDVTVSSVESVLAHL
SIO_010081: YLR109W
subclass of: SO_0000673
so part of: YLR109W
location: 368781..369311
location: region:368781-369311:1
so has part: feature:368781-369311:1:exon

NP_013210.1
type: Protein
SIO_000068: ncbiprotein

S000004099
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368781-369311:1:exon

YLR110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CCW12
locus tag: YLR110C
so part of: sequence
location: complement(<369697..>370098)
location: region:369697-370098:-1
so has part: feature:369697-370098:-1:exon
subclass of: SO_0000010

850800
type: Gene
SIO_000068: ncbigene

position:369697:-1
position: 369697
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370098:-1
position: 370098
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:369697-370098:-1:exon

YLR110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CCW12
locus tag: YLR110C
product: Ccw12p
transcript id: NM_001181997.1
SIO_010081: YLR110C
subclass of: SO_0000673
so part of: YLR110C
location: complement(<369697..>370098)
location: region:369697-370098:-1
so has part: feature:369697-370098:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:369697-370098:-1:exon

YLR110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CCW12
locus tag: YLR110C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:21320323]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:21320323]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:10322008|PMID:21320323]
experiment: EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:10322008]
experiment: EXISTENCE:mutant phenotype:GO:0005199 structural constituent of cell wall [PMID:17315267|PMID:21320323]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10322008|PMID:15972461|PMID:21320323]
note: Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
codon start: 1
product: Ccw12p
translation: MQFSTVASIAAVAAVASAAANVTTATVSQESTTLVTITSCEDHVCSETVSPALVSTATVTVDDVITQYTTWCPLTTEAPKNGTSTAAPVTSTEAPKNTTSAAPTHSVTSYTGAAAKALPAAGALLAGAAALLL
SIO_010081: YLR110C
subclass of: SO_0000673
so part of: YLR110C
location: complement(369697..370098)
location: region:369697-370098:-1
so has part: feature:369697-370098:-1:exon

NP_013211.1
type: Protein
SIO_000068: ncbiprotein

S000004100
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:369697-370098:-1:exon

YLR111W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR111W
so part of: sequence
location: <370391..>370723
location: region:370391-370723:1
so has part: feature:370391-370723:1:exon
subclass of: SO_0000010

850801
type: Gene
SIO_000068: ncbigene

position:370391:1
position: 370391
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370723:1
position: 370723
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370391-370723:1:exon

YLR111W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR111W
product: uncharacterized protein
transcript id: NM_001348854.1
SIO_010081: YLR111W
subclass of: SO_0000673
so part of: YLR111W
location: <370391..>370723
location: region:370391-370723:1
so has part: feature:370391-370723:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370391-370723:1:exon

YLR111W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR111W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MGNSKTNGFFTPEKYLYGIIQGLPPTLRGLAFIFFFLVAFYFFPAFWDLCGVLRGARGKGFPKRKSDANSQHSKQFWTHSDFPIWFLRVLIPTRASINSMKYPHTAALVR
SIO_010081: YLR111W
subclass of: SO_0000673
so part of: YLR111W
location: 370391..370723
location: region:370391-370723:1
so has part: feature:370391-370723:1:exon

NP_001335794.1
type: Protein
SIO_000068: ncbiprotein

S000004101
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370391-370723:1:exon

YLR112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR112W
so part of: sequence
location: <370791..>371210
location: region:370791-371210:1
so has part: feature:370791-371210:1:exon
subclass of: SO_0000010

850802
type: Gene
SIO_000068: ncbigene

position:370791:1
position: 370791
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371210:1
position: 371210
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370791-371210:1:exon

YLR112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR112W
product: uncharacterized protein
transcript id: NM_001348855.1
SIO_010081: YLR112W
subclass of: SO_0000673
so part of: YLR112W
location: <370791..>371210
location: region:370791-371210:1
so has part: feature:370791-371210:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370791-371210:1:exon

YLR112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR112W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MGGRSAQPRRFSFACRILHPAVAHDAMAGSRYILRAPASIIRLAQHGWLHCCLHFFLFPAMNDVCFVAKGSALYLFTVEIIVFGSPSLRHNVLSFFYFALPWFKRQCRLKVNFNRLKEIRGIAQVVRKAFFISKTLPCI
SIO_010081: YLR112W
subclass of: SO_0000673
so part of: YLR112W
location: 370791..371210
location: region:370791-371210:1
so has part: feature:370791-371210:1:exon

NP_001335795.1
type: Protein
SIO_000068: ncbiprotein

S000004102
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370791-371210:1:exon

YLR113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSK3
gene: HOG1
locus tag: YLR113W
gene synonym: SSK3
so part of: sequence
location: <371620..>372927
location: region:371620-372927:1
so has part: feature:371620-372927:1:exon
subclass of: SO_0000010

850803
type: Gene
SIO_000068: ncbigene

position:371620:1
position: 371620
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:372927:1
position: 372927
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371620-372927:1:exon

YLR113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSK3
gene: HOG1
locus tag: YLR113W
gene synonym: SSK3
product: mitogen-activated protein kinase HOG1
transcript id: NM_001182000.1
SIO_010081: YLR113W
subclass of: SO_0000673
so part of: YLR113W
location: <371620..>372927
location: region:371620-372927:1
so has part: feature:371620-372927:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371620-372927:1:exon

YLR113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSK3
gene: HOG1
locus tag: YLR113W
gene synonym: SSK3
EC number: 2.7.11.24
experiment: EXISTENCE:direct assay:GO:0001100 negative regulation of exit from mitosis [PMID:32265285]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24508389]
experiment: EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:10805732|PMID:32265285]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10817757]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10817757|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23178807]
experiment: EXISTENCE:direct assay:GO:0033262 regulation of nuclear cell cycle DNA replication [PMID:23178807]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12743037]
experiment: EXISTENCE:mutant phenotype:GO:0006972 hyperosmotic response [PMID:7681220]
experiment: EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:7681220]
experiment: EXISTENCE:mutant phenotype:GO:0016241 regulation of macroautophagy [PMID:16874103]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:23435728|PMID:24508389]
experiment: EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:27421986]
note: Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress
codon start: 1
product: mitogen-activated protein kinase HOG1
translation: MTTNEEFIRTQIFGTVFEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDPTDEPVADAKFDWHFNDADLPVDTWRVMMYSEILDFHKIGGSDGQIDISATFDDQVAAATAAAAQAQAQAQAQVQLNMAAHSHNGAGTTGNDHSDIAGGNKVSDHVAANDTITDYGNQAIQYANEFQQ
SIO_010081: YLR113W
subclass of: SO_0000673
so part of: YLR113W
location: 371620..372927
location: region:371620-372927:1
so has part: feature:371620-372927:1:exon

NP_013214.1
type: Protein
SIO_000068: ncbiprotein

S000004103
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371620-372927:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1213; Autonomously Replicating Sequence
so part of: sequence
location: 373254..373332
location: region:373254-373332:1
so has part: feature:373254-373332:1:region

S000118473
type: SGD
SIO_000068: sgd

position:373254:1
position: 373254
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:373332:1
position: 373332
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373254-373332:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 373999..374338
location: region:373999-374338:1
so has part: feature:373999-374338:1:region

S000007095
type: SGD
SIO_000068: sgd

position:373999:1
position: 373999
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:374338:1
position: 374338
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373999-374338:1:region

YNCL0007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0007W
so part of: sequence
location: 374355..374427
location: region:374355-374427:1
so has part: feature:374355-374427:1:exon
subclass of: SO_0000663

850804
type: Gene
SIO_000068: ncbigene

position:374355:1
position: 374355
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:374427:1
position: 374427
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374355-374427:1:exon

YNCL0007W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0007W
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCL0007W
subclass of: SO_0000673
so part of: YNCL0007W
location: 374355..374427
location: region:374355-374427:1
so has part: feature:374355-374427:1:exon

S000006704
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374355-374427:1:exon

YLR114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVL9
locus tag: YLR114C
so part of: sequence
location: complement(<374944..>377238)
location: region:374944-377238:-1
so has part: feature:374944-377238:-1:exon
subclass of: SO_0000010

850805
type: Gene
SIO_000068: ncbigene

position:374944:-1
position: 374944
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:377238:-1
position: 377238
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374944-377238:-1:exon

YLR114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVL9
locus tag: YLR114C
product: Avl9p
transcript id: NM_001182001.1
SIO_010081: YLR114C
subclass of: SO_0000673
so part of: YLR114C
location: complement(<374944..>377238)
location: region:374944-377238:-1
so has part: feature:374944-377238:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:374944-377238:-1:exon

YLR114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVL9
locus tag: YLR114C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:17229886]
note: Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
codon start: 1
product: Avl9p
translation: MDEHEEAVIFGICLVDFHHKRGPEIEYWYGLPEGTQSAELWPNLPFQALPDGSHSFEETFTYFTLLYDERRQRSPPNGATDLSDDSINDNTTLFAISCSRQIKSDELVTKDKDVTRSTVQKAIVVISRQPIFGQIKDKLSIVTNAFFLQHDFGDRKIIQSLYENLKSIYTPASLVRNAENRLYIGLCLRKILHDFKRNALVLLKAIMLEKKIIVYGNDVEALCNLQFGLISLIPDLMSNLQDSGSPQLFQDISKLNVVDSFKSSNRESVLRFLGFPLPIFEKGGLFSPYTPLQQMNDIRSERTLFFMIGSSNTLLAEQKEELCHIFVNTDNSTVDILDKTLNPVLQLSSHDKKWIESISGIVSDTWNENDDETPKNSQFEGSEDFIRWQFEDYLTGLLSSVKLSDYLDLHKENDQALKTIPEDMLNSNPVHLFNLNWVQSWKETQNFLIFNSRTDDRLFDLFPPKHIYNGADTLSLLQQRFLATFHNLKRSSSNSSSNKNGHQSEEDIKDQESIESKKSVSQISVNPGKNTDKPAANLWNSWKEYFNKPKNTANEDVTESTEDLKNRSKTSNAIQKAMMGLGLHYKPDAETDQQSEEVGNSEDNEDDDTDEDSEDDDDDGGDDDDSEDDDDDDDGEGDENGDDGEGDENGDDGEGDENGDKEDSQDFSNGFTDVTNINTDHDKENEQNFEGNAENFNEDETVADKDIEGGPESNKNSDSKTDIYENDRNVEDSSKTRNTVKKSNEEGGANDAAIGNCVQDEEKL
SIO_010081: YLR114C
subclass of: SO_0000673
so part of: YLR114C
location: complement(374944..377238)
location: region:374944-377238:-1
so has part: feature:374944-377238:-1:exon

NP_013215.1
type: Protein
SIO_000068: ncbiprotein

S000004104
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374944-377238:-1:exon

YLR115W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YDH1
gene: CFT2
locus tag: YLR115W
gene synonym: YDH1
so part of: sequence
location: <377985..>380564
location: region:377985-380564:1
so has part: feature:377985-380564:1:exon
subclass of: SO_0000010

850806
type: Gene
SIO_000068: ncbigene

position:377985:1
position: 377985
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:380564:1
position: 380564
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:377985-380564:1:exon

YLR115W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YDH1
gene: CFT2
locus tag: YLR115W
gene synonym: YDH1
product: cleavage polyadenylation factor subunit CFT2
transcript id: NM_001182002.1
SIO_010081: YLR115W
subclass of: SO_0000673
so part of: YLR115W
location: <377985..>380564
location: region:377985-380564:1
so has part: feature:377985-380564:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:377985-380564:1:exon

YLR115W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YDH1
gene: CFT2
locus tag: YLR115W
gene synonym: YDH1
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9099738]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:10523662|PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11344258]
experiment: EXISTENCE:direct assay:GO:0006379 mRNA cleavage [PMID:9099738]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11344258]
note: Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
codon start: 1
product: cleavage polyadenylation factor subunit CFT2
translation: MTYKYNCCDDGSGTTVGSVVRFDNVTLLIDPGWNPSKVSYEQCIKYWEKVIPEIDVIILSQPTIECLGAHSLLYYNFTSHFISRIQVYATLPVINLGRVSTIDSYASAGVIGPYDTNKLDLEDIEISFDHIVPLKYSQLVDLRSRYDGLTLLAYNAGVCPGGSIWCISTYSEKLVYAKRWNHTRDNILNAASILDATGKPLSTLMRPSAIITTLDRFGSSQPFKKRSKIFKDTLKKGLSSDGSVIIPVDMSGKFLDLFTQVHELLFESTKINAHTQVPVLILSYARGRTLTYAKSMLEWLSPSLLKTWENRNNTSPFEIGSRIKIIAPNELSKYPGSKICFVSEVGALINEVIIKVGNSEKTTLILTKPSFECASSLDKILEIVEQDERNWKTFPEDGKSFLCDNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKILLVKRESKKLANGNAIIDDTNGERAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNLLKDNSEKSAAKKNTEVPVDIIIQPSAASKHKMFPFNPAKIKKDDYGTVVDFTMFLPDDSDNVNQNSRKRPLKDGAKTTSPVNEEDNKNEEEDGYNMSDPISKRSKHRASRYSGFSGTGEAENFDNLDYLKIDKTLSKRTISTVNVQLKCSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAKLIKKNIEVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISDSYTVATVVGRLVKESLPQVNNHQKTASRSKLVLKPLHGSSRSHKTGALSIGDVRLAQLKKLLTEKNYIAEFKGEGTLVINEKVAVRKINDAETIIDGTPSELFDTVKKLVTDMLAKI
SIO_010081: YLR115W
subclass of: SO_0000673
so part of: YLR115W
location: 377985..380564
location: region:377985-380564:1
so has part: feature:377985-380564:1:exon

NP_013216.1
type: Protein
SIO_000068: ncbiprotein

S000004105
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:377985-380564:1:exon

YLR116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSL5
locus tag: YLR116W
so part of: sequence
location: <380822..>382252
location: region:380822-382252:1
so has part: feature:380822-382252:1:exon
subclass of: SO_0000010

850807
type: Gene
SIO_000068: ncbigene

position:380822:1
position: 380822
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382252:1
position: 382252
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:380822-382252:1:exon

YLR116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSL5
locus tag: YLR116W
product: mRNA splicing protein MSL5
transcript id: NM_001182003.1
SIO_010081: YLR116W
subclass of: SO_0000673
so part of: YLR116W
location: <380822..>382252
location: region:380822-382252:1
so has part: feature:380822-382252:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380822-382252:1:exon

YLR116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSL5
locus tag: YLR116W
experiment: EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:10376880|PMID:9150140]
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:9182766]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0045131 pre-mRNA branch point binding [PMID:9182766]
note: Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: mRNA splicing protein MSL5
translation: MSFRRINSRYFENRKGSSMEEKKAKVPPNVNLSLWRKNTVESDVHRFNSLPSKISGALTREQIYSYQVMFRIQEITIKLRTNDFVPPSRKNRSPSPPPVYDAQGKRTNTREQRYRKKLEDERIKLVEIALKTIPYFVPPDDYKRPTKFQDKYYIPVDQYPDVNFVGLLLGPRGRTLRKLQEDSNCKIAIRGRGSVKEGKNASDLPPGAMNFEDPLHCLIIADSEDKIQKGIKVCQNIVIKAVTSPEGQNDLKRGQLRELAELNGTLREDNRPCPICGLKDHKRYDCPNRKIPNIQGIVCKICGQTGHFSRDCNSSSQRMSRFDRNATVNNSAPIQSNDVHYNSNTHPIQAPKRSRYDNNSTEPPLKFPASSRYAPSPSPPASHISRQAQNVTPTPPPGLTSSSFSSGVPGIAPPPLQSPPESEQPKFSLPPPPGMTTVQSSIAPPPGLSGPPGFSNNMGNDINKPTPPGLQGPPGL
SIO_010081: YLR116W
subclass of: SO_0000673
so part of: YLR116W
location: 380822..382252
location: region:380822-382252:1
so has part: feature:380822-382252:1:exon

NP_013217.1
type: Protein
SIO_000068: ncbiprotein

S000004106
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380822-382252:1:exon

YLR117C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NTC77
alternative label: SYF3
gene: CLF1
locus tag: YLR117C
gene synonym: NTC77; SYF3
so part of: sequence
location: complement(<382471..>384534)
location: region:382471-384534:-1
so has part: feature:382471-384534:-1:exon
subclass of: SO_0000010

850808
type: Gene
SIO_000068: ncbigene

position:382471:-1
position: 382471
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384534:-1
position: 384534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:382471-384534:-1:exon

YLR117C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NTC77
alternative label: SYF3
gene: CLF1
locus tag: YLR117C
gene synonym: NTC77; SYF3
product: Clf1p
transcript id: NM_001182004.1
SIO_010081: YLR117C
subclass of: SO_0000673
so part of: YLR117C
location: complement(<382471..>384534)
location: region:382471-384534:-1
so has part: feature:382471-384534:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:382471-384534:-1:exon

YLR117C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NTC77
alternative label: SYF3
gene: CLF1
locus tag: YLR117C
gene synonym: NTC77; SYF3
experiment: EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:11105756|PMID:11842115]
experiment: EXISTENCE:curator inference:GO:0000386 second spliceosomal transesterification activity [PMID:11105756]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11973290]
experiment: EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11842115]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11973290]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11973290]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:11105756]
experiment: EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:11105756|PMID:11842115]
experiment: EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:11105756]
experiment: EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:11105756]
experiment: EXISTENCE:mutant phenotype:GO:0000354 cis assembly of pre-catalytic spliceosome [PMID:10445879|PMID:12509417]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:11973290]
experiment: EXISTENCE:physical interaction:GO:0000354 cis assembly of pre-catalytic spliceosome [PMID:10445879]
experiment: EXISTENCE:physical interaction:GO:0006270 DNA replication initiation [PMID:11973290]
note: Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
codon start: 1
product: Clf1p
translation: MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDDDKPKPSKFLELAKKWKQEQAL
SIO_010081: YLR117C
subclass of: SO_0000673
so part of: YLR117C
location: complement(382471..384534)
location: region:382471-384534:-1
so has part: feature:382471-384534:-1:exon

NP_013218.1
type: Protein
SIO_000068: ncbiprotein

S000004107
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:382471-384534:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1214; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 384534..384725
location: region:384534-384725:1
so has part: feature:384534-384725:1:region

S000130182
type: SGD
SIO_000068: sgd

position:384534:1
position: 384534
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:384725:1
position: 384725
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:384534-384725:1:region

YLR118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APT1
gene: TML25
locus tag: YLR118C
gene synonym: APT1
so part of: sequence
location: complement(<384725..>385408)
location: region:384725-385408:-1
so has part: feature:384725-385408:-1:exon
subclass of: SO_0000010

850809
type: Gene
SIO_000068: ncbigene

position:384725:-1
position: 384725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:385408:-1
position: 385408
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:384725-385408:-1:exon

YLR118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APT1
gene: TML25
locus tag: YLR118C
gene synonym: APT1
product: palmitoyl-(protein) hydrolase
transcript id: NM_001182005.1
SIO_010081: YLR118C
subclass of: SO_0000673
so part of: YLR118C
location: complement(<384725..>385408)
location: region:384725-385408:-1
so has part: feature:384725-385408:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:384725-385408:-1:exon

YLR118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APT1
gene: TML25
locus tag: YLR118C
gene synonym: APT1
EC number: 3.1.2.22
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008474 palmitoyl-(protein) hydrolase activity [PMID:12080046]
experiment: EXISTENCE:direct assay:GO:0035601 protein deacylation [PMID:12080046]
experiment: EXISTENCE:mutant phenotype:GO:0008474 palmitoyl-(protein) hydrolase activity [PMID:12080046]
experiment: EXISTENCE:mutant phenotype:GO:0035601 protein deacylation [PMID:12080046]
note: Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
codon start: 1
product: palmitoyl-(protein) hydrolase
translation: MNGLRVAAKIQPARQTIIFLHGLGDTGSGWGFLAQYLQQRDPAAFQHTNFVFPNAPELHVTANGGALMPAWFDILEWDPSFSKVDSDGFMNSLNSIEKTVKQEIDKGIKPEQIIIGGFSQGAALALATSVTLPWKIGGIVALSGFCSIPGILKQHKNGINVKTPIFHGHGDMDPVVPIGLGIKAKQFYQDSCEIQNYEFKVYKGMAHSTVPDELEDLASFIKKSLSS
SIO_010081: YLR118C
subclass of: SO_0000673
so part of: YLR118C
location: complement(384725..385408)
location: region:384725-385408:-1
so has part: feature:384725-385408:-1:exon

NP_013219.1
type: Protein
SIO_000068: ncbiprotein

S000004108
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:384725-385408:-1:exon

YLR119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SRN10
alternative label: VPL16
alternative label: VPS37
gene: SRN2
locus tag: YLR119W
gene synonym: SRN10; VPL16; VPS37
so part of: sequence
location: <385534..>386175
location: region:385534-386175:1
so has part: feature:385534-386175:1:exon
subclass of: SO_0000010

850810
type: Gene
SIO_000068: ncbigene

position:385534:1
position: 385534
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:386175:1
position: 386175
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:385534-386175:1:exon

YLR119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SRN10
alternative label: VPL16
alternative label: VPS37
gene: SRN2
locus tag: YLR119W
gene synonym: SRN10; VPL16; VPS37
product: ESCRT-I subunit protein SRN2
transcript id: NM_001182006.1
SIO_010081: YLR119W
subclass of: SO_0000673
so part of: YLR119W
location: <385534..>386175
location: region:385534-386175:1
so has part: feature:385534-386175:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:385534-386175:1:exon

YLR119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SRN10
alternative label: VPL16
alternative label: VPS37
gene: SRN2
locus tag: YLR119W
gene synonym: SRN10; VPL16; VPS37
experiment: EXISTENCE:curator inference:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15086794]
experiment: EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:15044434]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:11511343]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:11511343]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11511343]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
experiment: EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:16615894|PMID:11511343]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:11511343|PMID:15086794]
note: Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
codon start: 1
product: ESCRT-I subunit protein SRN2
translation: MKVKATKLRIKQRRKNKGLNISRLDIIRAEMDVVPSPGLPEKVNEKSKNIPLPEGINLLSSKEIIDLIQTHRHQLELYVTKFNPLTDFAGKIHAFRDQFKQLEENFEDLHEQKDKVQALLENCRILESKYVASWQDYHSEFSKKYGDIALKKKLEQNTKKLDEESSQLETTTRSIDSADDLDQFIKNYLDIRTQYHLRREKLATWDKQGNLKY
SIO_010081: YLR119W
subclass of: SO_0000673
so part of: YLR119W
location: 385534..386175
location: region:385534-386175:1
so has part: feature:385534-386175:1:exon

NP_013220.1
type: Protein
SIO_000068: ncbiprotein

S000004109
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:385534-386175:1:exon

YLR120C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YAP3
gene: YPS1
locus tag: YLR120C
gene synonym: YAP3
so part of: sequence
location: complement(<386511..>388220)
location: region:386511-388220:-1
so has part: feature:386511-388220:-1:exon
subclass of: SO_0000010

850811
type: Gene
SIO_000068: ncbigene

position:386511:-1
position: 386511
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388220:-1
position: 388220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:386511-388220:-1:exon

YLR120C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YAP3
gene: YPS1
locus tag: YLR120C
gene synonym: YAP3
product: aspartyl protease
transcript id: NM_001182007.1
SIO_010081: YLR120C
subclass of: SO_0000673
so part of: YLR120C
location: complement(<386511..>388220)
location: region:386511-388220:-1
so has part: feature:386511-388220:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:386511-388220:-1:exon

YLR120C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YAP3
gene: YPS1
locus tag: YLR120C
gene synonym: YAP3
EC number: 3.4.23.41
experiment: EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:8389368|PMID:8626758]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7657670]
experiment: EXISTENCE:genetic interaction:GO:0016485 protein processing [PMID:18591427]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]
experiment: EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:2183521]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:18591427]
experiment: EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:18591427]
note: Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor
codon start: 1
product: aspartyl protease
translation: MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKPEVRLLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSNSMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPASEATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAVANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLNDSDAMHGTILFGAVDHSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKTLTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGGFHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYNTTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASATSTSSKRNVGDHIVPSLPLTLISLLFAFI
SIO_010081: YLR120C
subclass of: SO_0000673
so part of: YLR120C
location: complement(386511..388220)
location: region:386511-388220:-1
so has part: feature:386511-388220:-1:exon

NP_013221.1
type: Protein
SIO_000068: ncbiprotein

S000004110
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:386511-388220:-1:exon

YLR121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YPS4
gene: YPS3
locus tag: YLR121C
gene synonym: YPS4
so part of: sequence
location: complement(<388744..>390270)
location: region:388744-390270:-1
so has part: feature:388744-390270:-1:exon
subclass of: SO_0000010

850812
type: Gene
SIO_000068: ncbigene

position:388744:-1
position: 388744
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:390270:-1
position: 390270
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388744-390270:-1:exon

YLR121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YPS4
gene: YPS3
locus tag: YLR121C
gene synonym: YPS4
product: aspartyl protease
transcript id: NM_001182008.1
SIO_010081: YLR121C
subclass of: SO_0000673
so part of: YLR121C
location: complement(<388744..>390270)
location: region:388744-390270:-1
so has part: feature:388744-390270:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:388744-390270:-1:exon

YLR121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YPS4
gene: YPS3
locus tag: YLR121C
gene synonym: YPS4
experiment: EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:10191273]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11016834]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]
note: Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
codon start: 1
product: aspartyl protease
translation: MKLQLAAVATLAVLTSPAFGRVLPDGKYVKIPFTKKKNGDNGELSKRSNGHEKFVLANEQSFYSVELAIGTPSQNLTVLLDTGSADLWVPGKGNPYCGSVMDCDQYGVFDKTKSSTFKANKSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAVANESNSTFGVLGIGLSTLEVTYSGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLNDESQSSGSILFGAVDHSKYEGQLYTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITLTTTKLPALLDSGTTLTYLPSQAVALLAKSLNASYSKTLGYYEYTCPSSDNKTSVAFDFGGFRINAPLSDFTMQTSVGTCVLAIIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAKYGTGKENVEVIKSTVPSAIRAPSYNNTWSNYASATSGGNIFTTVRTFNGTSTATTTRSTTTKKTNSTTTAKSTHKSKRALQRAATNSASSIRSTLGLLLVPSLLILSVFFS
SIO_010081: YLR121C
subclass of: SO_0000673
so part of: YLR121C
location: complement(388744..390270)
location: region:388744-390270:-1
so has part: feature:388744-390270:-1:exon

NP_013222.1
type: Protein
SIO_000068: ncbiprotein

S000004111
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:388744-390270:-1:exon

YLR122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR122C
so part of: sequence
location: complement(<390954..>391331)
location: region:390954-391331:-1
so has part: feature:390954-391331:-1:exon
subclass of: SO_0000010

850813
type: Gene
SIO_000068: ncbigene

position:390954:-1
position: 390954
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:391331:-1
position: 391331
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390954-391331:-1:exon

YLR122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR122C
product: uncharacterized protein
transcript id: NM_001348856.1
SIO_010081: YLR122C
subclass of: SO_0000673
so part of: YLR122C
location: complement(<390954..>391331)
location: region:390954-391331:-1
so has part: feature:390954-391331:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390954-391331:-1:exon

YLR122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR122C
note: hypothetical protein; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C
codon start: 1
product: uncharacterized protein
translation: MNRLYQNCMFLYVYTDVCVRLCASIFYIMLEAKFALRIPALRPSYTWGQWRSFIQSSFYGRTFVAFSGPSMKNYITICFLLKSIEVSVDRTALHGTSAEASASNFQRIQTKNLSKYNCNIPACCV
SIO_010081: YLR122C
subclass of: SO_0000673
so part of: YLR122C
location: complement(390954..391331)
location: region:390954-391331:-1
so has part: feature:390954-391331:-1:exon

NP_001335796.1
type: Protein
SIO_000068: ncbiprotein

S000004112
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390954-391331:-1:exon

YLR125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR125W
so part of: sequence
location: <393484..>393894
location: region:393484-393894:1
so has part: feature:393484-393894:1:exon
subclass of: SO_0000010

850816
type: Gene
SIO_000068: ncbigene

position:393484:1
position: 393484
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393894:1
position: 393894
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:393484-393894:1:exon

YLR125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR125W
product: uncharacterized protein
transcript id: NM_001182012.1
SIO_010081: YLR125W
subclass of: SO_0000673
so part of: YLR125W
location: <393484..>393894
location: region:393484-393894:1
so has part: feature:393484-393894:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:393484-393894:1:exon

YLR125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR125W
note: hypothetical protein; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MGEILELTNKNFMSHLKKDITSQESLKSRIEDKNGDVASPKEDNYPLLNETAAWPDGVITSEEGCSSSGEKENSGLCSEESSEEDPEEAEEESARAFGELVAVLRDKDIPLNVLDEPQMKDWLEKYTGVYRSSWHG
SIO_010081: YLR125W
subclass of: SO_0000673
so part of: YLR125W
location: 393484..393894
location: region:393484-393894:1
so has part: feature:393484-393894:1:exon

NP_013226.1
type: Protein
SIO_000068: ncbiprotein

S000004115
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:393484-393894:1:exon

YLR126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR126C
so part of: sequence
location: complement(<394765..>395520)
location: region:394765-395520:-1
so has part: feature:394765-395520:-1:exon
subclass of: SO_0000010

850817
type: Gene
SIO_000068: ncbigene

position:394765:-1
position: 394765
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:395520:-1
position: 395520
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394765-395520:-1:exon

YLR126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR126C
product: putative amidotransferase
transcript id: NM_001182013.1
SIO_010081: YLR126C
subclass of: SO_0000673
so part of: YLR126C
location: complement(<394765..>395520)
location: region:394765-395520:-1
so has part: feature:394765-395520:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394765-395520:-1:exon

YLR126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR126C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
note: Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
codon start: 1
product: putative amidotransferase
translation: MTVKKIAILYTDEDNEWSKPWGNFVDMAIKLLEQTRKLECIAEDVEYEVFHVQKNVFPQLSDLQKDEYLGIYITGSKYDSFDNEIEWIMKLRSFLNEMLTSKTEYPPVAGICFGHQVIAAALGSSVGRNPKGFEGGVVSLKLNSVGQKLFGAQELNLSEVHSDCVFDVPEGYQNWASSEKCQNQGFYRQNRVLTFQGHPEFNSDVAQKGLLKSQDKLTLEEFNRYERQCQELDNNGIQAARNIWRLFLQKI
SIO_010081: YLR126C
subclass of: SO_0000673
so part of: YLR126C
location: complement(394765..395520)
location: region:394765-395520:-1
so has part: feature:394765-395520:-1:exon

NP_013227.1
type: Protein
SIO_000068: ncbiprotein

S000004116
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394765-395520:-1:exon

YLR127C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RSI1
alternative label: TID2
gene: APC2
locus tag: YLR127C
gene synonym: RSI1; TID2
so part of: sequence
location: complement(<395758..>398319)
location: region:395758-398319:-1
so has part: feature:395758-398319:-1:exon
subclass of: SO_0000010

850818
type: Gene
SIO_000068: ncbigene

position:395758:-1
position: 395758
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:398319:-1
position: 398319
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:395758-398319:-1:exon

YLR127C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RSI1
alternative label: TID2
gene: APC2
locus tag: YLR127C
gene synonym: RSI1; TID2
product: anaphase promoting complex subunit 2
transcript id: NM_001182014.1
SIO_010081: YLR127C
subclass of: SO_0000673
so part of: YLR127C
location: complement(<395758..>398319)
location: region:395758-398319:-1
so has part: feature:395758-398319:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:395758-398319:-1:exon

YLR127C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RSI1
alternative label: TID2
gene: APC2
locus tag: YLR127C
gene synonym: RSI1; TID2
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:genetic interaction:GO:0007091 metaphase/anaphase transition of mitotic cell cycle [PMID:9430641]
experiment: EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:9430641]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473|PMID:9430641]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0120151 positive regulation of mitotic actomyosin contractile ring disassembly [PMID:19109423]
note: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
codon start: 1
product: anaphase promoting complex subunit 2
translation: MSFQITPTRDLKVITDELQTLSSYIFHTNIVDDLNSLLTWMSPNDAKSNHQLRPPSLRIKNIIKVLFPNNATTSPYSMINTSQANNSIVNEGNTNKELQLQLFSTLKEFYIFQVRYHFFLHFNNINYLKDIQRWENYYEFPLRYVPIFDVNVNDWALELNSLRHYLLNRNIKFKNNLRTRLDKLIMDDDFDLADNLIQWLKSANGSLSSTELIVNALYSKINKFCEDNMSRVWNKRFMIMETFNKFINQYWSQFSKLVGCPEDDHELTTTVFNCFESNFLRIRTNEIFDICVLAYPDSKVTLLELRKIMKDFKDYTNIVTTFLSDFKKYILNPSVTTVDALLRYVKTIKAFLVLDPTGRCLHSITTFVKPYFQERKHLVNVLLYAMLDLPEEELKEKINFNVDMKALLSLVDTLHDSDINQDTNITKRDKNKKSPFLWNLKVKGKRELNKDLPIRHAMLYEHILNYYIAWVPEPNDMIPGNIKSSYIKTNLFEVLLDLFESREFFISEFRNLLTDRLFTLKFYTLDEKWTRCLKLIREKIVKFTETSHSNYITNGILGLLETTAPAADADQSNLNSIDVMLWDIKCSEELCRKMHEVAGLDPIIFPKFISLLYWKYNCDTQGSNDLAFHLPIDLERELQKYSDIYSQLKPGRKLQLCKDKGKVEIQLAFKDGRKLVLDVSLEQCSVINQFDSPNDEPICLSLEQLSESLNIAPPRLTHLLDFWIQKGVLLKENGTYSVIEHSEMDFDQAQKTAPMEIENSNYELHNDSEIERKYELTLQRSLPFIEGMLTNLGAMKLHKIHSFLKITVPKDWGYNRITLQQLEGYLNTLADEGRLKYIANGSYEIVKNGHKNS
SIO_010081: YLR127C
subclass of: SO_0000673
so part of: YLR127C
location: complement(395758..398319)
location: region:395758-398319:-1
so has part: feature:395758-398319:-1:exon

NP_013228.1
type: Protein
SIO_000068: ncbiprotein

S000004117
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:395758-398319:-1:exon

YLR128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DCN1
locus tag: YLR128W
so part of: sequence
location: <398530..>399433
location: region:398530-399433:1
so has part: feature:398530-399433:1:exon
subclass of: SO_0000010

850819
type: Gene
SIO_000068: ncbigene

position:398530:1
position: 398530
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:399433:1
position: 399433
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:398530-399433:1:exon

YLR128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DCN1
locus tag: YLR128W
product: NEDD8 ligase DCN1
transcript id: NM_001182015.1
SIO_010081: YLR128W
subclass of: SO_0000673
so part of: YLR128W
location: join(<398530..398532,398627..>399433)
location: region:398530-399433:1
so has part: feature:398530-398532:1:exon
so has part: feature:398627-399433:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:398530-398532:1:exon

position:398532:1
position: 398532
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:398627-399433:1:exon

position:398627:1
position: 398627
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DCN1
locus tag: YLR128W
experiment: EXISTENCE:direct assay:GO:0031624 ubiquitin conjugating enzyme binding [PMID:18206966]
experiment: EXISTENCE:direct assay:GO:0032182 ubiquitin-like protein binding [PMID:15988528]
experiment: EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:15988528|PMID:18206966]
experiment: EXISTENCE:genetic interaction:GO:0045116 protein neddylation [PMID:15988528]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:18206966]
experiment: EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:15988528|PMID:18206966]
experiment: EXISTENCE:mutant phenotype:GO:0051443 positive regulation of ubiquitin-protein transferase activity [PMID:15988528]
experiment: EXISTENCE:mutant phenotype:GO:0097602 cullin family protein binding [PMID:18206966]
note: Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
codon start: 1
product: NEDD8 ligase DCN1
translation: MSNNKIKRKDASPEQEAIESFTSLTKCDPKVSRKYLQRNHWNINYALNDYYDKEIGTFTDEVSTVAHPPVYPKELTQVFEHYINNNLFDIDSLVKFIEELGYNLEDLATLCLAHLLGYKKLEEPLKREDFLSTWFMQGCSTISDMQECIKTLDVKLHEDLQYFTQIYNYAFNLILDPNRKDIDTDEGIQYWKLFFQPEYPVRMEPDLLEAWFRFLRDEGKTTISKDTWRMLLLFFKRYPTIQKIISDYDETAAWPFIIDEFYECLQDQQ
SIO_010081: YLR128W
subclass of: SO_0000673
so part of: YLR128W
location: join(398530..398532,398627..399433)
location: region:398530-399433:1
so has part: feature:398530-398532:1:exon
so has part: feature:398627-399433:1:exon

NP_013229.1
type: Protein
SIO_000068: ncbiprotein

S000004118
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:398530-398532:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:398627-399433:1:exon

YLR129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UTP12
gene: DIP2
locus tag: YLR129W
gene synonym: UTP12
so part of: sequence
location: <399657..>402488
location: region:399657-402488:1
so has part: feature:399657-402488:1:exon
subclass of: SO_0000010

850820
type: Gene
SIO_000068: ncbigene

position:399657:1
position: 399657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402488:1
position: 402488
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:399657-402488:1:exon

YLR129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UTP12
gene: DIP2
locus tag: YLR129W
gene synonym: UTP12
product: snoRNA-binding rRNA-processing protein DIP2
transcript id: NM_001182016.1
SIO_010081: YLR129W
subclass of: SO_0000673
so part of: YLR129W
location: <399657..>402488
location: region:399657-402488:1
so has part: feature:399657-402488:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:399657-402488:1:exon

YLR129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UTP12
gene: DIP2
locus tag: YLR129W
gene synonym: UTP12
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
codon start: 1
product: snoRNA-binding rRNA-processing protein DIP2
translation: MVKSYQRFEQAAAFGVIASNANCVWIPASSGNSNGSGPGQLITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVFLEEEKEKELEEQYEDTLLTSLEEGNGDDAFKADASGEGVEDEASGVHKQTLESLKAGERLMEALDLGIAEIEGLEAYNRDMKLWQRKKLGEAPIKPQGNAVLIAVNKTPEQYIMDTLLRIRMSQLEDALMVMPFSYVLKFLKFIDTVMQNKTLLHSHLPLICKNLFFIIKFNHKELVSQKNEELKLQINRVKTELRSALKSTEDDLGFNVQGLKFVKQQWNLRHNYEFVDEYDQQEKESNSARKRVFGTVI
SIO_010081: YLR129W
subclass of: SO_0000673
so part of: YLR129W
location: 399657..402488
location: region:399657-402488:1
so has part: feature:399657-402488:1:exon

NP_013230.1
type: Protein
SIO_000068: ncbiprotein

S000004119
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:399657-402488:1:exon

YLR130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZRT2
locus tag: YLR130C
so part of: sequence
location: complement(<402794..>404062)
location: region:402794-404062:-1
so has part: feature:402794-404062:-1:exon
subclass of: SO_0000010

850821
type: Gene
SIO_000068: ncbigene

position:402794:-1
position: 402794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:404062:-1
position: 404062
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402794-404062:-1:exon

YLR130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZRT2
locus tag: YLR130C
product: low-affinity Zn(2+) transporter ZRT2
transcript id: NM_001182017.1
SIO_010081: YLR130C
subclass of: SO_0000673
so part of: YLR130C
location: complement(<402794..>404062)
location: region:402794-404062:-1
so has part: feature:402794-404062:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402794-404062:-1:exon

YLR130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZRT2
locus tag: YLR130C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000007 low-affinity zinc ion transmembrane transporter activity [PMID:8798516]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8798516]
experiment: EXISTENCE:mutant phenotype:GO:0071578 zinc ion import across plasma membrane [PMID:8798516]
note: Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
codon start: 1
product: low-affinity Zn(2+) transporter ZRT2
translation: MVDLIARDDSVDTCQASNGYNGHAGLRILAVFIILISSGLGVYFPILSSRYSFIRLPNWCFFIAKFFGSGVIVATAFVHLLQPAAEALGDECLGGTFAEYPWAFGICLMSLFLLFFTEIITHYFVAKTLGHDHGDHGEVTSIDVDAPSSGFVIRNMDSDPVSFNNEAAYSIHNDKTPYTTRNEEIVATPIKEKEPGSNVTNYDLEPGKTESLANELVPTSSHATNLASVPGKDHYSHENDHQDVSQLATRIEEEDKEQYLNQILAVFILEFGIIFHSVFVGLSLSVAGEEFETLFIVLTFHQMFEGLGLGTRVAETNWPESKKYMPWLMGLAFTLTSPIAVAVGIGVRHSWIPGSRRALIANGVFDSISSGILIYTGLVELMAHEFLYSNQFKGPDGLKKMLSAYLIMCCGAALMALLGKWA
SIO_010081: YLR130C
subclass of: SO_0000673
so part of: YLR130C
location: complement(402794..404062)
location: region:402794-404062:-1
so has part: feature:402794-404062:-1:exon

NP_013231.1
type: Protein
SIO_000068: ncbiprotein

S000004120
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402794-404062:-1:exon

YLR131C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACE2
locus tag: YLR131C
so part of: sequence
location: complement(<404510..>406822)
location: region:404510-406822:-1
so has part: feature:404510-406822:-1:exon
subclass of: SO_0000010

850822
type: Gene
SIO_000068: ncbigene

position:404510:-1
position: 404510
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:406822:-1
position: 406822
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:404510-406822:-1:exon

YLR131C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACE2
locus tag: YLR131C
product: DNA-binding transcription factor ACE2
transcript id: NM_001182018.1
SIO_010081: YLR131C
subclass of: SO_0000673
so part of: YLR131C
location: complement(<404510..>406822)
location: region:404510-406822:-1
so has part: feature:404510-406822:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:404510-406822:-1:exon

YLR131C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACE2
locus tag: YLR131C
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8657150]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15200949|PMID:1730413|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15200949|PMID:1730413]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:10409653|PMID:1730413]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8657150]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]
experiment: EXISTENCE:mutant phenotype:GO:2001043 positive regulation of septum digestion after cytokinesis [PMID:11259593]
note: Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1
codon start: 1
product: DNA-binding transcription factor ACE2
translation: MDNVVDPWYINPSGFAKDTQDEEYVQHHDNVNPTIPPPDNYILNNENDDGLDNLLGMDYYNIDDLLTQELRDLDIPLVPSPKTGDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRGLSGTAIFGFLGHNKTLSISSLQQSILNMSKDPQPMELINELGNHNTVKNNNDDFDHIRENDGENSYLSQVLLKQQEELRIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEEQEEVAQKLVSGATNSNSKPGSPVILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSINGSPSRKYHRQRYPNKSPESNGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNNTSDKNNNDKKNSTGDNIFRLFEKTSPGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGTFTPRTQLSPIHKKRESVVSTVSTISQLQDDTEPIHMRNTQNPTLRNANALASSSVLPPIPGSSNNTPIKNSLPQKHVFQHTPVKAPPKNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHCEVESYPQVPPVTHDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPDKLFECLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISHNAKKYICPCGKRFNREDALMVHRSRMICTGGKKLEHSINKKLTSPKKSLLDSPHDTSPVKETIARDKDGSVLMKMEEQLRDDMRKHGLLDPPPSTAAHEQNSNRTLSNETDAL
SIO_010081: YLR131C
subclass of: SO_0000673
so part of: YLR131C
location: complement(404510..406822)
location: region:404510-406822:-1
so has part: feature:404510-406822:-1:exon

NP_013232.1
type: Protein
SIO_000068: ncbiprotein

S000004121
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:404510-406822:-1:exon

YLR132C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: USB1
locus tag: YLR132C
so part of: sequence
location: complement(<407283..>408155)
location: region:407283-408155:-1
so has part: feature:407283-408155:-1:exon
subclass of: SO_0000010

850823
type: Gene
SIO_000068: ncbigene

position:407283:-1
position: 407283
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:408155:-1
position: 408155
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407283-408155:-1:exon

YLR132C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: USB1
locus tag: YLR132C
product: phosphoric diester hydrolase
transcript id: NM_001182019.1
SIO_010081: YLR132C
subclass of: SO_0000673
so part of: YLR132C
location: complement(<407283..>408155)
location: region:407283-408155:-1
so has part: feature:407283-408155:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407283-408155:-1:exon

YLR132C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: USB1
locus tag: YLR132C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22027258|PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22027258|PMID:14562095|PMID:14690591]
experiment: EXISTENCE:genetic interaction:GO:0034477 U6 snRNA 3'-end processing [PMID:22899009]
experiment: EXISTENCE:mutant phenotype:GO:0034477 U6 snRNA 3'-end processing [PMID:22899009]
note: Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2',3' cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)
codon start: 1
product: phosphoric diester hydrolase
translation: MEFISADYSSSDGSDTESESSNKSEVQIEYTEKTCIQKADSTDLPAIPDSIILKYHIPPNLQKYEHQDMNMSRFWRSFTYFEWRPTPAIHRQLQKIICKYKETFMKQEYTNPYQLVDFDPLFISHLGAPKPLHVSLTRSLLFETEEQRHVFIQEMRNGLRNNEITPFKLQICSYPKLYISERANTLYLGLPVSECPNKAQISPFKTIIAEALQKSGISNYQDLIVSRQNLHVSIAIASNPSKATLKRYQQLNETMGALLLLNNDFAYKLEFLVNSIYCDENRHSIRIPFN
SIO_010081: YLR132C
subclass of: SO_0000673
so part of: YLR132C
location: complement(407283..408155)
location: region:407283-408155:-1
so has part: feature:407283-408155:-1:exon

NP_013233.1
type: Protein
SIO_000068: ncbiprotein

S000004122
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407283-408155:-1:exon

YLR133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CKI1
locus tag: YLR133W
so part of: sequence
location: <408445..>410193
location: region:408445-410193:1
so has part: feature:408445-410193:1:exon
subclass of: SO_0000010

850824
type: Gene
SIO_000068: ncbigene

position:408445:1
position: 408445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:410193:1
position: 410193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408445-410193:1:exon

YLR133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CKI1
locus tag: YLR133W
product: bifunctional choline kinase/ethanolamine kinase CKI1
transcript id: NM_001182020.1
SIO_010081: YLR133W
subclass of: SO_0000673
so part of: YLR133W
location: <408445..>410193
location: region:408445-410193:1
so has part: feature:408445-410193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:408445-410193:1:exon

YLR133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CKI1
locus tag: YLR133W
EC number: 2.7.1.32
experiment: EXISTENCE:direct assay:GO:0004103 choline kinase activity [PMID:2536698]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004103 choline kinase activity [PMID:10329685]
experiment: EXISTENCE:genetic interaction:GO:0004305 ethanolamine kinase activity [PMID:10329685]
experiment: EXISTENCE:genetic interaction:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]
experiment: EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]
experiment: EXISTENCE:mutant phenotype:GO:0004103 choline kinase activity [PMID:10329685]
experiment: EXISTENCE:mutant phenotype:GO:0004305 ethanolamine kinase activity [PMID:10329685]
experiment: EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]
experiment: EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]
note: Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
codon start: 1
product: bifunctional choline kinase/ethanolamine kinase CKI1
translation: MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL
SIO_010081: YLR133W
subclass of: SO_0000673
so part of: YLR133W
location: 408445..410193
location: region:408445-410193:1
so has part: feature:408445-410193:1:exon

NP_013234.1
type: Protein
SIO_000068: ncbiprotein

S000004123
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:408445-410193:1:exon

YLR134W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDC5
locus tag: YLR134W
so part of: sequence
location: <410723..>412414
location: region:410723-412414:1
so has part: feature:410723-412414:1:exon
subclass of: SO_0000010

850825
type: Gene
SIO_000068: ncbigene

position:410723:1
position: 410723
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412414:1
position: 412414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410723-412414:1:exon

YLR134W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDC5
locus tag: YLR134W
product: indolepyruvate decarboxylase 5
transcript id: NM_001182021.1
SIO_010081: YLR134W
subclass of: SO_0000673
so part of: YLR134W
location: <410723..>412414
location: region:410723-412414:1
so has part: feature:410723-412414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410723-412414:1:exon

YLR134W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDC5
locus tag: YLR134W
EC number: 4.1.1.43
EC number: 4.1.1.72
EC number: 4.1.1.74
experiment: EXISTENCE:direct assay:GO:0004737 pyruvate decarboxylase activity [PMID:2185016|PMID:23423327]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:16850348]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006090 pyruvate metabolic process [PMID:2185016]
experiment: EXISTENCE:direct assay:GO:0019655 glycolytic fermentation to ethanol [PMID:2185016]
experiment: EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
experiment: EXISTENCE:genetic interaction:GO:0004737 pyruvate decarboxylase activity [PMID:2185016]
experiment: EXISTENCE:genetic interaction:GO:0006090 pyruvate metabolic process [PMID:2185016]
experiment: EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]
experiment: EXISTENCE:genetic interaction:GO:0006569 tryptophan catabolic process [PMID:12499363]
experiment: EXISTENCE:genetic interaction:GO:0019655 glycolytic fermentation to ethanol [PMID:2185016]
experiment: EXISTENCE:mutant phenotype:GO:0047433 branched-chain-2-oxoacid decarboxylase activity [PMID:9546164]
note: Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
codon start: 1
product: indolepyruvate decarboxylase 5
translation: MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEVKGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIANAPAEIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDAEAEAEVVRTVVELIKDAKNPVILADACASRHDVKAETKKLMDLTQFPVYVTPMGKGAIDEQHPRYGGVYVGTLSRPEVKKAVESADLILSIGALLSDFNTGSFSYSYKTKNIVEFHSDHIKIRNATFPGVQMKFALQKLLDAIPEVVKDYKPVAVPARVPITKSTPANTPMKQEWMWNHLGNFLREGDIVIAETGTSAFGINQTTFPTDVYAIVQVLWGSIGFTVGALLGATMAAEELDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYIFVLNNNGYTIEKLIHGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKDFQDNSKIRMIEVMLPVFDAPQNLVKQAQLTAATNAKQ
SIO_010081: YLR134W
subclass of: SO_0000673
so part of: YLR134W
location: 410723..412414
location: region:410723-412414:1
so has part: feature:410723-412414:1:exon

NP_013235.1
type: Protein
SIO_000068: ncbiprotein

S000004124
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410723-412414:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1215; Autonomously Replicating Sequence
so part of: sequence
location: 412686..412893
location: region:412686-412893:1
so has part: feature:412686-412893:1:region

S000118474
type: SGD
SIO_000068: sgd

position:412686:1
position: 412686
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:412893:1
position: 412893
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412686-412893:1:region

YLR135W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLX4
locus tag: YLR135W
so part of: sequence
location: <413281..>415527
location: region:413281-415527:1
so has part: feature:413281-415527:1:exon
subclass of: SO_0000010

850826
type: Gene
SIO_000068: ncbigene

position:413281:1
position: 413281
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:415527:1
position: 415527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413281-415527:1:exon

YLR135W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLX4
locus tag: YLR135W
product: Slx4p
transcript id: NM_001182022.1
SIO_010081: YLR135W
subclass of: SO_0000673
so part of: YLR135W
location: <413281..>415527
location: region:413281-415527:1
so has part: feature:413281-415527:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413281-415527:1:exon

YLR135W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLX4
locus tag: YLR135W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12832395]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:12832395]
experiment: EXISTENCE:genetic interaction:GO:0000727 double-strand break repair via break-induced replication [PMID:23071463]
experiment: EXISTENCE:genetic interaction:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]
experiment: EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12832395]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:11139495]
experiment: EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]
experiment: EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12228808]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:12228808]
experiment: EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:26490958]
experiment: EXISTENCE:mutant phenotype:GO:1905261 regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:27172214]
experiment: EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:26490958]
experiment: EXISTENCE:physical interaction:GO:0033557 Slx1-Slx4 complex [PMID:12832395]
note: Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor
codon start: 1
product: Slx4p
translation: MELQRAQRNLKFLQNEDYVNVTDQTNLNGESQNAYSLGMETQVPEMQFSLSSDDDSIGTQVKSVTAQKSPMTQETTKNDTERNKDVDKSCNPVSTSHPDLGGSNIEENIFINTQIQSRLDDAEEETNLKLKLEKFKYSFKSSNADDTHSNANVTAKRRPAIRKANSKLKTKPKTKRDPKIIKNITDFNINNYERSRTASLLKQLSGKHKKVLDIIKTQNEGNSDKPPRARNNKGEKATFDTYSEQEWKDIMKLLLQKFPQSEETDLNEVQKFLYGSEKSSNSLDNQESSQQRLWTASQLPPELPDEAIQPEQEERIRDTQSAVNFLSLSQVMDDKSEIMKDEESIIISRGDSTSSQEYGNGLEPQQPVGNVVGEDIELAVGTRINAFSLTDYKACKPMSVEVSRRCENSTDNDYDNISIVSDTTDETSTLFPLDQYRYVFIENDERPPLATDTIGSTQFFTPNTSPLDGIIDLTQESFKAVRSLISPLKVENNKTGVTSQASNQVQVPATRTPTIIPQKNLTTTLKTEEEKNNIGSSIRVKLLQESVVKLNPKLVKHNFYRVEANDSEEEETEFDDQFCIADIQLVDSSKISTKDSTQNPTTSNDIIDTSAASSIASPEKFCEIMMSQSMKELRQSLKTVGLKPMRTKVEIIQSLQTASQILSTANPDNKGEHGGVANFSKIEIFDHLTELIEAFPDFLERIYTFEPIPLNELIEKLFSAEPFVSQIDEMTIREWADVQGICLRNDKK
SIO_010081: YLR135W
subclass of: SO_0000673
so part of: YLR135W
location: 413281..415527
location: region:413281-415527:1
so has part: feature:413281-415527:1:exon

NP_013236.1
type: Protein
SIO_000068: ncbiprotein

S000004125
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413281-415527:1:exon

YLR136C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTH2
gene: TIS11
locus tag: YLR136C
gene synonym: CTH2
so part of: sequence
location: complement(<415801..>416658)
location: region:415801-416658:-1
so has part: feature:415801-416658:-1:exon
subclass of: SO_0000010

850827
type: Gene
SIO_000068: ncbigene

position:415801:-1
position: 415801
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416658:-1
position: 416658
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:415801-416658:-1:exon

YLR136C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTH2
gene: TIS11
locus tag: YLR136C
gene synonym: CTH2
product: Tis11p
transcript id: NM_001182023.1
SIO_010081: YLR136C
subclass of: SO_0000673
so part of: YLR136C
location: complement(<415801..>416658)
location: region:415801-416658:-1
so has part: feature:415801-416658:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:415801-416658:-1:exon

YLR136C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTH2
gene: TIS11
locus tag: YLR136C
gene synonym: CTH2
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:15652485|PMID:35858543]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922|PMID:18923425]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21135132|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:35858543]
experiment: EXISTENCE:direct assay:GO:0015990 electron transport coupled proton transport [PMID:35858543]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:29912874]
experiment: EXISTENCE:direct assay:GO:0045182 translation regulator activity [PMID:35858543]
experiment: EXISTENCE:direct assay:GO:1990641 response to iron ion starvation [PMID:29912874]
experiment: EXISTENCE:direct assay:GO:2000766 negative regulation of cytoplasmic translation [PMID:35858543]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:15652485]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:15652485]
note: mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; represses mitochondrial function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication
codon start: 1
product: Tis11p
translation: MWAQLSYTRPESQKTDLTSLFSTDQEQNPLNDYQYQINIRELEEYYNKTILNEDNIQETSSEISSAVSFSPPKNTNAIQPGLLYDPQLMNPFLPSAHLNSTAPTTFKKKLEVQINPDYVPKSSQLPLTSQNLQQLSQQKPKNDASFSSEKESSAQPKVKSQVQETPKQLYKTELCESFTLKGSCPYGSKCQFAHGLGELKVKKSCKNFRTKPCVNWEKLGYCPYGRRCCFKHGDDNDIAVYVKAGTYCNVSSTSKQSDEKRSNGRGSAKKKNLNVKVKALQRMTW
SIO_010081: YLR136C
subclass of: SO_0000673
so part of: YLR136C
location: complement(415801..416658)
location: region:415801-416658:-1
so has part: feature:415801-416658:-1:exon

NP_013237.1
type: Protein
SIO_000068: ncbiprotein

S000004126
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:415801-416658:-1:exon

YLR137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RKM5
locus tag: YLR137W
so part of: sequence
location: <417006..>418109
location: region:417006-418109:1
so has part: feature:417006-418109:1:exon
subclass of: SO_0000010

850828
type: Gene
SIO_000068: ncbigene

position:417006:1
position: 417006
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:418109:1
position: 418109
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417006-418109:1:exon

YLR137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RKM5
locus tag: YLR137W
product: S-adenosylmethionine-dependent methyltransferase
transcript id: NM_001182024.1
SIO_010081: YLR137W
subclass of: SO_0000673
so part of: YLR137W
location: <417006..>418109
location: region:417006-418109:1
so has part: feature:417006-418109:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417006-418109:1:exon

YLR137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RKM5
locus tag: YLR137W
experiment: EXISTENCE:direct assay:GO:0006479 protein methylation [PMID:21460220]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:21460220]
note: Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
codon start: 1
product: S-adenosylmethionine-dependent methyltransferase
translation: MAFKLWLLDEETIYEHVFERYTQLEGQSGKLAQDLGIQDRRGGVLEITFEPSGLEGGRKKKRVRRRNKASSVEEDQNVAVDSYHVSVGQSISSLRSSRDNGNSTTGYVLWSTTPFFINWLLYSTSAAPFRLGSQVEVTCGSSCEGHKLELPRLVDLTGADRGKRGILELGAGISGILPVILGNFVDTYVSTDQKGILNKLKDNIMENLSQLTRKRCISRSLRLELPTVEPVGDADITAASLPSKSTLHLEVAALDWEKINLQDKKTHSLHPELSLIGETCSSVYVIAMDVIYNEYLIDPFLKTLKQLKHWLQTTYNLQFHVLVGIHLRSQEVTTLFLEKAIIEYDFTVYDIVDQVIQESRFNFYLIT
SIO_010081: YLR137W
subclass of: SO_0000673
so part of: YLR137W
location: 417006..418109
location: region:417006-418109:1
so has part: feature:417006-418109:1:exon

NP_013238.1
type: Protein
SIO_000068: ncbiprotein

S000004127
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417006-418109:1:exon

YLR138W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NHA1
locus tag: YLR138W
so part of: sequence
location: <418437..>421394
location: region:418437-421394:1
so has part: feature:418437-421394:1:exon
subclass of: SO_0000010

850829
type: Gene
SIO_000068: ncbigene

position:418437:1
position: 418437
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:421394:1
position: 421394
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:418437-421394:1:exon

YLR138W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NHA1
locus tag: YLR138W
product: Nha1p
transcript id: NM_001182025.1
SIO_010081: YLR138W
subclass of: SO_0000673
so part of: YLR138W
location: <418437..>421394
location: region:418437-421394:1
so has part: feature:418437-421394:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:418437-421394:1:exon

YLR138W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NHA1
locus tag: YLR138W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15950597|PMID:9802016]
experiment: EXISTENCE:direct assay:GO:0015385 sodium:proton antiporter activity [PMID:15950597]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:19254924]
experiment: EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:16402204]
experiment: EXISTENCE:mutant phenotype:GO:0015491 cation:cation antiporter activity [PMID:9802016]
experiment: EXISTENCE:mutant phenotype:GO:0030004 cellular monovalent inorganic cation homeostasis [PMID:9802016]
experiment: EXISTENCE:mutant phenotype:GO:0030007 cellular potassium ion homeostasis [PMID:16402204]
experiment: EXISTENCE:mutant phenotype:GO:0036376 sodium ion export across plasma membrane [PMID:9802016]
experiment: EXISTENCE:mutant phenotype:GO:0097623 potassium ion export across plasma membrane [PMID:9802016]
note: Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
codon start: 1
product: Nha1p
translation: MAIWEQLEVSKAHVAYACVGVFSSIFSLVSLYVKEKLYIGESTVAGIFGLIVGPVCLNWFNPLKWGNSDSITLEITRIVLCLQIFAVAVELPRKYMLKHWVSVTMLLLPVMTAGWLIIGLFVWILIPGLNFSASLLISACITATDPILAQSVVSGKFAQRVPGHLRNLLSAESGCNDGMAFPFLFLSMNLILHPGNGREIVKDWICVTILYECLFGCLLGCFIGYVGRITIRFAEKKNIIDRESFLAFYVVLAFMCAGFGSILGVDDLLVSFAAGATFAWDGWFSQKTQESNVSTVIDLLLNYAYFIYFGAIIPWSQFNNGEIGTNVWRLIILSIVVIFLRRIPAVMILRPLIPDIKSWREALFVGHFGPIGVGAIFAAILARGELESTFSDEPTPLNVVPSKEESKHWQLIACIWPITCFFIVTSIIVHGSSVAIITLGRHLNTITLTKTFTTHTTNGDNGKSSWMQRLPSLDKAGRSFSLHRMDTQMTLSGDEGEAEEGGGRKGLAGGEDEEGLNNDQIGSVATSGIPARPAGGMPRRRKLSRKEKRLNRRQKLRNKGREIFSSRSKNEMYDDDELNDLGRERLQKEKEARAATFALSTAVNTQRNEEIGMGGDEEEDEYTPEKEYSDNYNNTPSFESSERSSSLRGRTYVPRNRYDGEETESEIESEDEMENESERSMASSEERRIRKMKEEEMKPGTAYLDGNRMIIENKQGEILNQVDIEDRNEARDDEVSVDSTAHSSLTTTMTNLSSSSGGRLKRILTPTSLGKIHSLVDKGKDKNKNSKYHAFKIDNLLIIENEDGDVIKRYKINPHKSDDDKSKNRPRNDSVVSRALTAVGLKSKANSGVPPPVDEEKAIEGPSRKGPGMLKKRTLTPAPPRGVQDSLDLEDEPSSEEDLGDSYNMDDSEDYDDNAYESETEFERQRRLNALGEMTAPADQDDEELPPLPVEAQTGNDGPGTAEGKKKQKSAAVKSALSKTLGLNK
SIO_010081: YLR138W
subclass of: SO_0000673
so part of: YLR138W
location: 418437..421394
location: region:418437-421394:1
so has part: feature:418437-421394:1:exon

NP_013239.1
type: Protein
SIO_000068: ncbiprotein

S000004128
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:418437-421394:1:exon

YLR139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLS1
locus tag: YLR139C
so part of: sequence
location: complement(<421542..>423473)
location: region:421542-423473:-1
so has part: feature:421542-423473:-1:exon
subclass of: SO_0000010

850830
type: Gene
SIO_000068: ncbigene

position:421542:-1
position: 421542
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:423473:-1
position: 423473
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:421542-423473:-1:exon

YLR139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLS1
locus tag: YLR139C
product: Sls1p
transcript id: NM_001182026.1
SIO_010081: YLR139C
subclass of: SO_0000673
so part of: YLR139C
location: complement(<421542..>423473)
location: region:421542-423473:-1
so has part: feature:421542-423473:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:421542-423473:-1:exon

YLR139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLS1
locus tag: YLR139C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8917313]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:8917313]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:12637560|PMID:15692048]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8917313]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12637560]
note: Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
codon start: 1
product: Sls1p
translation: MWKFNKKLARLTYRLYSSSGPSSPLHGKKKLPQNLKFVVLNPTQSGLVKNDQKQPRHRPSKKRSHKETGDNNLDFGSKLLVFEKQNSLDSALNSIRLKKPTSASLPSLEYNALLQSLTSSYNRYQLREFISTHQPDSSSHLTHWKKSKLSQYIIEKIWNCQPISTPTTPTGIKSTSLTFQFDSPREIFLLLITQNGKILTNFNKLGLTFIISIQDNELTVKGSPSLLKYAEISLNKIWSNITHENVRMYSLMPSKDVINLIQKETHTFFEYLPDLQMYKISALSTKKISMAKVFLLNAVASNPNTTQHHHTIASPALKTELYPFNNTLENLDWLNKSQDWARLQSVVPKNCTDLMTPTENATPELTDAQVSQFESSLSKNIPSLSPSDSISQSLSITLGHSLQSASFSSIFQPLIHKSFISKLLNLPMYKESSSSAVPVPVPLDQHLITNAHQSFIQLNFTPVPPTSGSSSSPFLQIWFEIDEFDNIVTTSMRPLLKLQENSVILRTPQCQTDYKITSDYIQDLLPDFDQTNPDAWLSEQKGLQEFLLKSHWKLNKYQNLMKKINISLPDNLIQQYQLTDVLTHRVLNLRFPTNTAQDDKYIIQYSDISRGFLNNGSYRQLDFINVNPSETSLKTFINDVLSF
SIO_010081: YLR139C
subclass of: SO_0000673
so part of: YLR139C
location: complement(421542..423473)
location: region:421542-423473:-1
so has part: feature:421542-423473:-1:exon

NP_013240.1
type: Protein
SIO_000068: ncbiprotein

S000004129
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:421542-423473:-1:exon

YLR141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRN5
locus tag: YLR141W
so part of: sequence
location: <423683..>424774
location: region:423683-424774:1
so has part: feature:423683-424774:1:exon
subclass of: SO_0000010

850832
type: Gene
SIO_000068: ncbigene

position:423683:1
position: 423683
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:424774:1
position: 424774
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423683-424774:1:exon

YLR141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRN5
locus tag: YLR141W
product: Rrn5p
transcript id: NM_001182028.1
SIO_010081: YLR141W
subclass of: SO_0000673
so part of: YLR141W
location: <423683..>424774
location: region:423683-424774:1
so has part: feature:423683-424774:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:423683-424774:1:exon

YLR141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRN5
locus tag: YLR141W
experiment: EXISTENCE:direct assay:GO:0000500 RNA polymerase I upstream activating factor complex [PMID:8846924]
experiment: EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:8846924]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]
experiment: EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:20154141]
experiment: EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]
note: Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
codon start: 1
product: Rrn5p
translation: MEHQQLRKYVELYNKEVEEFYNGAASGRPAEFHPSKVHVKSIHEKAGTANAGVEISSVGVDWDSEEKNTFFWCLSRYSIHRVDEWRSLLPRKSAMEILGYYRLLRRASASARSRKAGDDGAPIAYEMSAEWVALETKLSETVMAITEGAAEVADEEGHCEGLIDYESWKRRWVAIYSHSRIAEIRPLPRHALPLSRSATQTLERCVSRYTRTLLWCTALAGMASRSVSARAAESRGHKSLPTVVTRRQVERALCTEARSRDLHVLPRRIVLTLRKWELDYPREGKLFRTKEMAHLFLQSQLSRRDAPPVHQDENQENQENQENQEQDNTASEGESEAERDEIDEADLFRSALHENQLLKWLSK
SIO_010081: YLR141W
subclass of: SO_0000673
so part of: YLR141W
location: 423683..424774
location: region:423683-424774:1
so has part: feature:423683-424774:1:exon

NP_013242.1
type: Protein
SIO_000068: ncbiprotein

S000004131
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423683-424774:1:exon

YLR142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUT1
locus tag: YLR142W
so part of: sequence
location: <425186..>426616
location: region:425186-426616:1
so has part: feature:425186-426616:1:exon
subclass of: SO_0000010

850833
type: Gene
SIO_000068: ncbigene

position:425186:1
position: 425186
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426616:1
position: 426616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:425186-426616:1:exon

YLR142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUT1
locus tag: YLR142W
product: proline dehydrogenase
transcript id: NM_001182029.1
SIO_010081: YLR142W
subclass of: SO_0000673
so part of: YLR142W
location: <425186..>426616
location: region:425186-426616:1
so has part: feature:425186-426616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:425186-426616:1:exon

YLR142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUT1
locus tag: YLR142W
EC number: 1.5.5.2
experiment: EXISTENCE:curator inference:GO:0006537 glutamate biosynthetic process [PMID:387737]
experiment: EXISTENCE:direct assay:GO:0004657 proline dehydrogenase activity [PMID:20450881]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:3125423|PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0010133 proline catabolic process to glutamate [PMID:20450881]
experiment: EXISTENCE:mutant phenotype:GO:0004657 proline dehydrogenase activity [PMID:387737]
experiment: EXISTENCE:mutant phenotype:GO:0010133 proline catabolic process to glutamate [PMID:387737]
note: Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
codon start: 1
product: proline dehydrogenase
translation: MIASKSSLLVTKSRIPSLCFPLIKRSYVSKTPTHSNTAANLMVETPAANANGNSVMAPPNSINFLQTLPKKELFQLGFIGIATLNSFFLNTIIKLFPYIPIPVIKFFVSSLYCGGENFKEVIECGKRLQKRGISNMMLSLTIENSEGTKSLSSTPVDQIVKETISSVHNILLPNIIGQLESKPINDIAPGYIALKPSALVDNPHEVLYNFSNPAYKAQRDQLIENCSKITKEIFELNQSLLKKYPERKAPFMVSTIDAEKYDLQENGVYELQRILFQKFNPTSSKLISCVGTWQLYLRDSGDHILHELKLAQENGYKLGLKLVRGAYIHSEKNRNQIIFGDKTGTDENYDRIITQVVNDLIINGEDSYFGHLVVASHNYQSQMLVTNLLKSTQDNSYAKSNIVLGQLLGMADNVTYDLITNHGAKNIIKYVPWGPPLETKDYLLRRLQENGDAVRSDNGWPLIKAIAKSIPKRVGL
SIO_010081: YLR142W
subclass of: SO_0000673
so part of: YLR142W
location: 425186..426616
location: region:425186-426616:1
so has part: feature:425186-426616:1:exon

NP_013243.1
type: Protein
SIO_000068: ncbiprotein

S000004132
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:425186-426616:1:exon

YNCL0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0008W
so part of: sequence
location: 427132..427203
location: region:427132-427203:1
so has part: feature:427132-427203:1:exon
subclass of: SO_0000663

850834
type: Gene
SIO_000068: ncbigene

position:427132:1
position: 427132
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:427203:1
position: 427203
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427132-427203:1:exon

YNCL0008W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0008W
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCL0008W
subclass of: SO_0000673
so part of: YNCL0008W
location: 427132..427203
location: region:427132-427203:1
so has part: feature:427132-427203:1:exon

S000006541
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427132-427203:1:exon

YLR143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPH6
locus tag: YLR143W
so part of: sequence
location: <427329..>429386
location: region:427329-429386:1
so has part: feature:427329-429386:1:exon
subclass of: SO_0000010

850835
type: Gene
SIO_000068: ncbigene

position:427329:1
position: 427329
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:429386:1
position: 429386
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427329-429386:1:exon

YLR143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPH6
locus tag: YLR143W
product: diphthine--ammonia ligase
transcript id: NM_001182030.1
SIO_010081: YLR143W
subclass of: SO_0000673
so part of: YLR143W
location: <427329..>429386
location: region:427329-429386:1
so has part: feature:427329-429386:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427329-429386:1:exon

YLR143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPH6
locus tag: YLR143W
EC number: 6.3.1.14
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0017178 diphthine-ammonia ligase activity [PMID:23169644]
experiment: EXISTENCE:direct assay:GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [PMID:23169644]
experiment: EXISTENCE:mutant phenotype:GO:0017178 diphthine-ammonia ligase activity [PMID:23169644]
experiment: EXISTENCE:mutant phenotype:GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [PMID:23169644|PMID:23468660]
note: Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
codon start: 1
product: diphthine--ammonia ligase
translation: MKFIALISGGKDSFYNIFHCLKNNHELIALGNIYPKESEEQELDSFMFQTVGHDLIDYYSKCIGVPLFRRSILRNTSNNVELNYTATQDDEIEELFELLRTVKDKIPDLEAVSVGAILSSYQRTRVENVCSRLGLVVLSYLWQRDQAELMGEMCLMSKDVNNVENDTNSGNKFDARIIKVAAIGLNEKHLGMSLPMMQPVLQKLNQLYQVHICGEGGEFETMVLDAPFFQHGYLELIDIVKCSDGEVHNARLKVKFQPRNLSKSFLLNQLDQLPVPSIFGNNWQDLTQNLPKQQAKTGEQRFENHMSNALPQTTINKTNDKLYISNLQSRKSETVEKQSEDIFTELADILHSNQIPRNHILSASLLIRDMSNFGKINKIYNEFLDLSKYGPLPPSRACVGSKCLPEDCHVQLSVVVDVKNTGKEKINKNKGGLHVQGRSYWAPCNIGPYSQSTWLNDDANQVSFISGQIGLVPQSMEILGTPLTDQIVLALQHFDTLCETIGAQEKLLMTCYISDESVLDSVIKTWAFYCSNMNHRSDLWMDKSDDVEKCLVLVKISELPRGAVAEFGGVTCKRLIVDDNDSDKKEREENDDVSTVFQKLNLNIEGFHNTTVSAFGYNRNFITGFVDSREELELILEKTPKSAQITLYYNPKEIITFHHHIGYYPVEKLFDYRGKEHRFGLHIRS
SIO_010081: YLR143W
subclass of: SO_0000673
so part of: YLR143W
location: 427329..429386
location: region:427329-429386:1
so has part: feature:427329-429386:1:exon

NP_013244.1
type: Protein
SIO_000068: ncbiprotein

S000004133
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427329-429386:1:exon

YLR144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ENG2
alternative label: PCA1
gene: ACF2
locus tag: YLR144C
gene synonym: ENG2; PCA1
so part of: sequence
location: complement(<429677..>432016)
location: region:429677-432016:-1
so has part: feature:429677-432016:-1:exon
subclass of: SO_0000010

850836
type: Gene
SIO_000068: ncbigene

position:429677:-1
position: 429677
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:432016:-1
position: 432016
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:429677-432016:-1:exon

YLR144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ENG2
alternative label: PCA1
gene: ACF2
locus tag: YLR144C
gene synonym: ENG2; PCA1
product: endo-1,3(4)-beta-glucanase
transcript id: NM_001182031.1
SIO_010081: YLR144C
subclass of: SO_0000673
so part of: YLR144C
location: complement(<429677..>432016)
location: region:429677-432016:-1
so has part: feature:429677-432016:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:429677-432016:-1:exon

YLR144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ENG2
alternative label: PCA1
gene: ACF2
locus tag: YLR144C
gene synonym: ENG2; PCA1
EC number: 3.2.1.6
experiment: EXISTENCE:direct assay:GO:0030036 actin cytoskeleton organization [PMID:9214384]
experiment: EXISTENCE:direct assay:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:17933563]
experiment: EXISTENCE:genetic interaction:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:12455695]
note: Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress
codon start: 1
product: endo-1,3(4)-beta-glucanase
translation: MCYSRQAIPPPVPNRPGGTTNRGPPPLPPRANVQPPVCSSENSSKPRENRVAGESLRTPSSSNPLADSQVNSDNIFQSPVLSNLKAPPSVFNKVQHPVPKPNIDDQSVDPLETNKFYTNMLLDDNTQPIWTHPYSIWFSRDPELFGLAANHTLASQRVFDTTTNPPRFYFNPTNIKSFVFKAREFVSSNDIKLEFRDMKHMSMCLLMSLSSSQFIEFPLVQGMGFVTAIYHDLGFELRSAVGFRSLERISVNERYGKYNIQLENNRNWILYLTSPDYSFPQDFQISLLDSNTIISSHKINGLICQLSADSVPSIDMAAGCYPVYCDLSGQTVDEHFTNYRFNYTVAGYSQSGTTLMYALPHHKAAFTPEMQEREIASSLDSTVKGLMTGYLTNSFDMQVQVPQELGFEPVALSLNKKADYSQEKLSKIREAAVQEVQLSDPQQESNIDSMYFSGKILAKYAWILYVTHYILHDENLTKELLSKLTIAMERFISNQQVLPLNYDVSWKGIISSGSSSQDFGNSYYNDHHFHYSYHVITAAIISLVDSDLSGVTNNSWLENNRDWVECLIRDYSGVDNDDPYFPQFRSFDWFNGHSWAKGLFPSGDGKDEESTSEDVNSCYAIKLWGLVTGNSKLTDIANLQLGIMRNVFQSYFLYESNNTVQPKEFIGNKVSGILFENKIDHATYFGMEPQYIHMIHAIPITSASSWVRTPNFVKEEWEEKMQPIIDQVNDGWKGIIMLNMALLDPKFSYDFFSQPDFNRNFLDNGQSLTWSLAYSGAFS
SIO_010081: YLR144C
subclass of: SO_0000673
so part of: YLR144C
location: complement(429677..432016)
location: region:429677-432016:-1
so has part: feature:429677-432016:-1:exon

NP_013245.1
type: Protein
SIO_000068: ncbiprotein

S000004134
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:429677-432016:-1:exon

YLR145W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMP1
locus tag: YLR145W
so part of: sequence
location: <432168..>432773
location: region:432168-432773:1
so has part: feature:432168-432773:1:exon
subclass of: SO_0000010

850837
type: Gene
SIO_000068: ncbigene

position:432168:1
position: 432168
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:432773:1
position: 432773
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432168-432773:1:exon

YLR145W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMP1
locus tag: YLR145W
product: Rmp1p
transcript id: NM_001182032.1
SIO_010081: YLR145W
subclass of: SO_0000673
so part of: YLR145W
location: <432168..>432773
location: region:432168-432773:1
so has part: feature:432168-432773:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432168-432773:1:exon

YLR145W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMP1
locus tag: YLR145W
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:15637077]
experiment: EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [PMID:14729943]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15637077]
experiment: EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]
note: Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
codon start: 1
product: Rmp1p
translation: MDEMDNVIRSLEQEYRLILLLNHRNKNQHRAASWYGSFNEMKRNCGQIITLFSSRRLQAKRLKDVEWVKLHRLLQRALFRQLKRWYWQFNGVIALGQFVTLGCTLVTLLANVRALYMRLWEINETEFIRCGCLIKNLPRTKAKSVVNDVEELGEIIDEDIGNNVQENELVITSIPKPLTENCKKKKKRKKKNKSAIDGIFG
SIO_010081: YLR145W
subclass of: SO_0000673
so part of: YLR145W
location: 432168..432773
location: region:432168-432773:1
so has part: feature:432168-432773:1:exon

NP_013246.1
type: Protein
SIO_000068: ncbiprotein

S000004135
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432168-432773:1:exon

YLR146C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPE4
locus tag: YLR146C
so part of: sequence
location: complement(<432823..>433725)
location: region:432823-433725:-1
so has part: feature:432823-433725:-1:exon
subclass of: SO_0000010

850838
type: Gene
SIO_000068: ncbigene

position:432823:-1
position: 432823
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433725:-1
position: 433725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432823-433725:-1:exon

YLR146C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPE4
locus tag: YLR146C
product: spermine synthase
transcript id: NM_001182033.1
SIO_010081: YLR146C
subclass of: SO_0000673
so part of: YLR146C
location: complement(<432823..>433725)
location: region:432823-433725:-1
so has part: feature:432823-433725:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432823-433725:-1:exon

YLR146C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPE4
locus tag: YLR146C
EC number: 2.5.1.22
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006597 spermine biosynthetic process [PMID:9573363]
experiment: EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]
experiment: EXISTENCE:mutant phenotype:GO:0016768 spermine synthase activity [PMID:9573363]
note: Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
codon start: 1
product: spermine synthase
translation: MVNNSQHPYIKDGWFREINDKSFPGQAFTMTVDSILYEARSEFQDILIFRNKVYGTVLVLDGIVQCTEFDEFAYQEMITHIAMFAHSNPKRVLIIGGGDGGVLREVAKHSCVEDITMVEIDSSVIELSRKFLPTLSNGAFDDERLDLKLCDGFKFLQDIGASDVHKKFDVIITDSSDPEGPAEAFFQERYFELLKDALNPNGVVIMQSSENFWLNLKYLHDLKNTAKKVFPNTEYCYTMVPTYTSGQLGLIVCSNNANIPLNIPQRKISEQEQGKLKYYNPQIHSSAFVLPTWADKVINE
SIO_010081: YLR146C
subclass of: SO_0000673
so part of: YLR146C
location: complement(432823..433725)
location: region:432823-433725:-1
so has part: feature:432823-433725:-1:exon

NP_013247.1
type: Protein
SIO_000068: ncbiprotein

S000004136
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432823-433725:-1:exon

YLR146W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR146W-A
so part of: sequence
location: <433870..>434058
location: region:433870-434058:1
so has part: feature:433870-434058:1:exon
subclass of: SO_0000010

3799977
type: Gene
SIO_000068: ncbigene

position:433870:1
position: 433870
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:434058:1
position: 434058
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:433870-434058:1:exon

YLR146W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR146W-A
product: uncharacterized protein
transcript id: NM_001184685.1
SIO_010081: YLR146W-A
subclass of: SO_0000673
so part of: YLR146W-A
location: <433870..>434058
location: region:433870-434058:1
so has part: feature:433870-434058:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:433870-434058:1:exon

YLR146W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR146W-A
codon start: 1
product: uncharacterized protein
translation: MDTEEKKKTTASVEHARMLQNEIQQLFAQLRDTNSQIRCDLNEFEQIKESSTTADSTTNSAN
SIO_010081: YLR146W-A
subclass of: SO_0000673
so part of: YLR146W-A
location: 433870..434058
location: region:433870-434058:1
so has part: feature:433870-434058:1:exon

NP_001032582.1
type: Protein
SIO_000068: ncbiprotein

S000113566
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:433870-434058:1:exon

YLR147C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLT16
gene: SMD3
locus tag: YLR147C
gene synonym: SLT16
so part of: sequence
location: complement(<434158..>434463)
location: region:434158-434463:-1
so has part: feature:434158-434463:-1:exon
subclass of: SO_0000010

850839
type: Gene
SIO_000068: ncbigene

position:434158:-1
position: 434158
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:434463:-1
position: 434463
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434158-434463:-1:exon

YLR147C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLT16
gene: SMD3
locus tag: YLR147C
gene synonym: SLT16
product: mRNA splicing protein SMD3
transcript id: NM_001182034.1
SIO_010081: YLR147C
subclass of: SO_0000673
so part of: YLR147C
location: complement(<434158..>434463)
location: region:434158-434463:-1
so has part: feature:434158-434463:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:434158-434463:-1:exon

YLR147C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLT16
gene: SMD3
locus tag: YLR147C
gene synonym: SLT16
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9012791|PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]
note: Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
codon start: 1
product: mRNA splicing protein SMD3
translation: MTMNGIPVKLLNEAQGHIVSLELTTGATYRGKLVESEDSMNVQLRDVIATEPQGAVTHMDQIFVRGSQIKFIVVPDLLKNAPLFKKNSSRPMPPIRGPKRR
SIO_010081: YLR147C
subclass of: SO_0000673
so part of: YLR147C
location: complement(434158..434463)
location: region:434158-434463:-1
so has part: feature:434158-434463:-1:exon

NP_013248.1
type: Protein
SIO_000068: ncbiprotein

S000004137
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434158-434463:-1:exon

YLR148W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VAM8
alternative label: VPS18
alternative label: VPT18
gene: PEP3
locus tag: YLR148W
gene synonym: VAM8; VPS18; VPT18
so part of: sequence
location: <434641..>437397
location: region:434641-437397:1
so has part: feature:434641-437397:1:exon
subclass of: SO_0000010

850840
type: Gene
SIO_000068: ncbigene

position:434641:1
position: 434641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437397:1
position: 437397
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434641-437397:1:exon

YLR148W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VAM8
alternative label: VPS18
alternative label: VPT18
gene: PEP3
locus tag: YLR148W
gene synonym: VAM8; VPS18; VPT18
product: tethering complex subunit PEP3
transcript id: NM_001182035.1
SIO_010081: YLR148W
subclass of: SO_0000673
so part of: YLR148W
location: <434641..>437397
location: region:434641-437397:1
so has part: feature:434641-437397:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:434641-437397:1:exon

YLR148W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VAM8
alternative label: VPS18
alternative label: VPT18
gene: PEP3
locus tag: YLR148W
gene synonym: VAM8; VPS18; VPT18
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10944212]
experiment: EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]
experiment: EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:11422941]
experiment: EXISTENCE:genetic interaction:GO:0045324 late endosome to vacuole transport [PMID:11422941]
experiment: EXISTENCE:mutant phenotype:GO:0006904 vesicle docking involved in exocytosis [PMID:10978279]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11030345]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]
experiment: EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]
note: Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
codon start: 1
product: tethering complex subunit PEP3
translation: MIKTRIEEVQLQFLTGNTELTHLKVSNDQLIVTTQRTIYRINLQDPAIVNHFDCPLSKELETIMNVHVSPMGSVILIRTNFGRYMLLKDGEFTQLNKIKNLDLSSLHWINETTFLMGIKKTPKLYRVELTGKDITTKLWYENKKLSGGIDGIAYWEGSLLLTIKDNILYWRDVTNMKFPLVLPDESEQFERLKHHAIKKFDSYNGLFAWVTSNGIVFGDLKEKQMEKDPASNNFGKFLSSSKVLLNFELPDYQNDKDHLIKDIVLTAFHILLLRKNTVTMVSQLNNDVVFHETIPRHQLTGSNTDSNEKFLGLVRDSVKETFWCFSNINVFEIIIENEPNSVWNLLVRDNKFDKALSLKGLTVREIESVKLSKAMYLFHTAKDFHSAAQTLGSMKDLSHFGEIALNFLQIKDYNDLNVILIKQLDNVPWKSTQVVLSSWIIWNFMKQLNDIELKINTTKPASTDEDNLLNWNLNLKEKSNELTKFLESHLEKLDNETVYQIMSKQNRQNELLIFASLINDMKFLLSFWIDQGNWYESLKILLTINNHDLVYKYSLILLLNSPEATVSTWMKIKDLDPNKLIPTILKFFTNWQNNSKLITNISEYPENYSLTYLKWCVREVPKMCNPIVYNSILYMMITDPRNDMILENDIIKFMKSNENKYDLNFQLRLSLKFKKTKTSIFLLTRLNLFEDAIDLALKNNLIDDCKVIVNDEILIEDYKLRKRLWLKIAKHLLLSMKDIDIKQLIRTILNDSNEILTIKDLLPFFNEYTTIANLKEELIKFLENHNMKMNEISEDIINSKNLKVEINTEISKFNEIYRILEPGKSCDECGKFLQIKKFIVFPCGHCFHWNCIIRVILNSNDYNLRQKTENFLKAKSKHNLNDLENIIVEKCGLCSDININKIDQPISIDETELAKWNE
SIO_010081: YLR148W
subclass of: SO_0000673
so part of: YLR148W
location: 434641..437397
location: region:434641-437397:1
so has part: feature:434641-437397:1:exon

NP_013249.1
type: Protein
SIO_000068: ncbiprotein

S000004138
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434641-437397:1:exon

YLR149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GID11
locus tag: YLR149C
so part of: sequence
location: complement(<437631..>439823)
location: region:437631-439823:-1
so has part: feature:437631-439823:-1:exon
subclass of: SO_0000010

850841
type: Gene
SIO_000068: ncbigene

position:437631:-1
position: 437631
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439823:-1
position: 439823
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437631-439823:-1:exon

YLR149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GID11
locus tag: YLR149C
product: Gid11p
transcript id: NM_001182036.1
SIO_010081: YLR149C
subclass of: SO_0000673
so part of: YLR149C
location: complement(<437631..>439823)
location: region:437631-439823:-1
so has part: feature:437631-439823:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437631-439823:-1:exon

YLR149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GID11
locus tag: YLR149C
note: Substrate receptor of the glucose-induced degradation-deficient (GID) complex that targets gluconeogenic enzymes for proteasomal degradation upon switch from ethanol to glucose as a carbon source; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; protein abundance increases in response to DNA replication stress
codon start: 1
product: Gid11p
translation: MTIDGTGQSKEALQDERLNTGSDKVYQNYMMPALELYDAKVSINHWQLRDCIKPGSMNQSKLYYIYDHSIRVLDTDSSVLRSPVRRHNSIQPSNSGKNSTEKTSTKGSRTTGSYISKNLHVPSEKLVEFNFKPRCFTELNGLTVCGGLIGSDDKGFPSNWNRLAQDANISLPPPSQPINISKNISFPINSHYSNPNIWKGIVEFYNQETDTMMTFTLGQFINNCVTLYDRASMQFDLFACNNDGHLYQCDVSNRDVTLVKRYADLKFPLNNASLSHDGQTMVVSGDSNKFAVYNQNELTNQFSLHYDNHPSWGSSVNRVRRIPRFALPDESEYIENIYEAPNSDHGFYNSFSENDLQFATVFQNGTCAIYDIRNMATPMAEISSTRPHSHNGAFRVCRFSYGLDDLLFISEHQGRVHVVDTRNYVNHQVIVIPDKVNMEYINERKHNTNHNFTTNNNNENESNDSKNELQGADYRSLSRRRFSLPSMPNVTTEPWITMAQRIPKKYLEPQILPFPKVMDKISNESVLFSTKGSSSSDVAHPYKRRCSFRVRRVSTSAPTADYSNNNVNASLGTPAADSIATSSSNSAPQNLIDPLILSHQQASNDVFEDDEYYEAYNDVHSTYRVSSDYHGVSARAFESFLRPPSTPDLPSDDDNFAANSRNNRGTSNFLRRPVITTQESNEFSEENNISGIDWVEDRNGSSLIIGTDYGIMRWNINSWARRSFSSYDLC
SIO_010081: YLR149C
subclass of: SO_0000673
so part of: YLR149C
location: complement(437631..439823)
location: region:437631-439823:-1
so has part: feature:437631-439823:-1:exon

NP_013250.1
type: Protein
SIO_000068: ncbiprotein

S000004139
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437631-439823:-1:exon

YLR150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPT4
gene: STM1
locus tag: YLR150W
gene synonym: MPT4
so part of: sequence
location: <440467..>441288
location: region:440467-441288:1
so has part: feature:440467-441288:1:exon
subclass of: SO_0000010

850843
type: Gene
SIO_000068: ncbigene

position:440467:1
position: 440467
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:441288:1
position: 441288
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440467-441288:1:exon

YLR150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPT4
gene: STM1
locus tag: YLR150W
gene synonym: MPT4
product: Stm1p
transcript id: NM_001182037.1
SIO_010081: YLR150W
subclass of: SO_0000673
so part of: YLR150W
location: <440467..>441288
location: region:440467-441288:1
so has part: feature:440467-441288:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440467-441288:1:exon

YLR150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPT4
gene: STM1
locus tag: YLR150W
gene synonym: MPT4
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:15654430]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15044472|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:15044472]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15044472]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:15044472]
experiment: EXISTENCE:direct assay:GO:0043066 negative regulation of apoptotic process [PMID:11514626]
experiment: EXISTENCE:direct assay:GO:0045142 triplex DNA binding [PMID:18029617]
experiment: EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:12207228]
experiment: EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:19666721]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:19666721]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:16580682]
experiment: EXISTENCE:mutant phenotype:GO:0043558 regulation of translational initiation in response to stress [PMID:16580682]
note: Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
codon start: 1
product: Stm1p
translation: MSNPFDLLGNDVEDADVVVLPPKEIVKSNTSSKKADVPPPSADPSKARKNRPRPSGNEGAIRDKTAGRRNNRSKDVTDSATTKKSNTRRATDRHSRTGKTDTKKKVNQGWGDDKKELSAEKEAQADAAAEIAEDAAEAEDAGKPKTAQLSLQDYLNQQANNQFNKVPEAKKVELDAERIETAEKEAYVPATKVKNVKSKQLKTKEYLEFDATFVESNTRKNFGDRNNNSRNNFNNRRGGRGARKGNNTANATNSANTVQKNRNIDVSNLPSLA
SIO_010081: YLR150W
subclass of: SO_0000673
so part of: YLR150W
location: 440467..441288
location: region:440467-441288:1
so has part: feature:440467-441288:1:exon

NP_013251.1
type: Protein
SIO_000068: ncbiprotein

S000004140
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440467-441288:1:exon

YLR151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCD1
locus tag: YLR151C
so part of: sequence
location: complement(<441715..>442737)
location: region:441715-442737:-1
so has part: feature:441715-442737:-1:exon
subclass of: SO_0000010

850844
type: Gene
SIO_000068: ncbigene

position:441715:-1
position: 441715
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442737:-1
position: 442737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441715-442737:-1:exon

YLR151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCD1
locus tag: YLR151C
product: 8-oxo-dGTP diphosphatase
transcript id: NM_001182038.1
SIO_010081: YLR151C
subclass of: SO_0000673
so part of: YLR151C
location: complement(<441715..>442737)
location: region:441715-442737:-1
so has part: feature:441715-442737:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441715-442737:-1:exon

YLR151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCD1
locus tag: YLR151C
EC number: 3.6.1.55
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:10922370]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [PMID:15475388]
experiment: EXISTENCE:direct assay:GO:0010945 CoA pyrophosphatase activity [PMID:10922370]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15475388]
experiment: EXISTENCE:mutant phenotype:GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [PMID:15475388]
note: 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1
codon start: 1
product: 8-oxo-dGTP diphosphatase
translation: MILSQRRMLSSKQLIENLIRYKFHKTPYTRSSIWPFKRNSAVIILLFIGMKGELRVLLTKRSRTLRSFSGDVSFPGGKADYFQETFESVARREAEEEIGLPHDPEVLHKEFGMKLDNLVMDMPCYLSRTFLSVKPMVCFLYKDKLEKHEDKYKVPLDIRKFFGKLNPGETSSLFSVPLNDLVIHLLPEADEDVKSYQAEYFERKEYKLNWGGIKWLIMHYHFHVANNNEMPWLQTIEDLSSSDEDGVDGGIFRFRDLWGLTCKILFDVSCIANGLMDEKLKGELGHEDLIVGLHDYGNQMQPNGRSEWEIGMINGDRNLKYSDVIPEYYMKHLLECRSLW
SIO_010081: YLR151C
subclass of: SO_0000673
so part of: YLR151C
location: complement(441715..442737)
location: region:441715-442737:-1
so has part: feature:441715-442737:-1:exon

NP_013252.1
type: Protein
SIO_000068: ncbiprotein

S000004141
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441715-442737:-1:exon

YLR152C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR152C
so part of: sequence
location: complement(<442958..>444688)
location: region:442958-444688:-1
so has part: feature:442958-444688:-1:exon
subclass of: SO_0000010

850845
type: Gene
SIO_000068: ncbigene

position:442958:-1
position: 442958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:444688:-1
position: 444688
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442958-444688:-1:exon

YLR152C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR152C
product: uncharacterized protein
transcript id: NM_001182039.1
SIO_010081: YLR152C
subclass of: SO_0000673
so part of: YLR152C
location: complement(<442958..>444688)
location: region:442958-444688:-1
so has part: feature:442958-444688:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:442958-444688:-1:exon

YLR152C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR152C
note: hypothetical protein; YLR152C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSLSLGAAIYIALKPIFKIYTIMLVGYLVAKFDIVSMENAKGISNMVVNAILPCLTFNKIVSNISWRDIKEIGVIILSAFILFVLGATGALFTTFATTVPKKFFWGLIFAGFFPNISDLPIAYIQSMGNGSIFTAEEADKGVAYSCIFLFIQSFLMMNFGMWRVVGLDFRDTKEPDSENITPSVSPAIDDRKLTEITKLPNITRPTNAYQSEDARSNSDLSCNSITTNEMTPQAFYEGFTGYIKPYKESNGASHKFESDLPHAEIYRVSSTYSSPGALEFSRIDGSSLSYSRISKNSDGRSYRRKRKADMNELISKYSAAEKIRQGELDLSRPLSLTEEVGSRNASIGNVHTGYTDESSIEEENCTNMATDGRGSLSFFIERHNLKWLQYFIINCLRPASLGAILGIICALIPWVKACFVTTYVHVHKAPDGEPVLNFLMDFTEYIGNACVPLGLLLLGGTLARLEIKSLPPGFIKSALLMTCFRLIVIPIIGVLWVNKLYSIDWLDTGIGKFDMILTWSMPSATAQVYFTAFYTPACGDHIQMNCLSVLFVMQYAILFITVAFVVTYTLKVDLKV
SIO_010081: YLR152C
subclass of: SO_0000673
so part of: YLR152C
location: complement(442958..444688)
location: region:442958-444688:-1
so has part: feature:442958-444688:-1:exon

NP_013253.1
type: Protein
SIO_000068: ncbiprotein

S000004142
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:442958-444688:-1:exon

YLR153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACS2
locus tag: YLR153C
so part of: sequence
location: complement(<445524..>447575)
location: region:445524-447575:-1
so has part: feature:445524-447575:-1:exon
subclass of: SO_0000010

850846
type: Gene
SIO_000068: ncbigene

position:445524:-1
position: 445524
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:447575:-1
position: 447575
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:445524-447575:-1:exon

YLR153C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACS2
locus tag: YLR153C
product: acetate--CoA ligase ACS2
transcript id: NM_001182040.1
SIO_010081: YLR153C
subclass of: SO_0000673
so part of: YLR153C
location: complement(<445524..>447575)
location: region:445524-447575:-1
so has part: feature:445524-447575:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:445524-447575:-1:exon

YLR153C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACS2
locus tag: YLR153C
EC number: 6.2.1.1
experiment: EXISTENCE:direct assay:GO:0003987 acetate-CoA ligase activity [PMID:8910545]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16857587|PMID:19618123]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19618123]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9711835|PMID:16857587]
experiment: EXISTENCE:direct assay:GO:0006085 acetyl-CoA biosynthetic process [PMID:8910545]
experiment: EXISTENCE:direct assay:GO:0016880 acid-ammonia (or amide) ligase activity [PMID:18305111]
experiment: EXISTENCE:mutant phenotype:GO:0016573 histone acetylation [PMID:16857587]
note: Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
codon start: 1
product: acetate--CoA ligase ACS2
translation: MTIKEHKVVYEAHNVKALKAPQHFYNSQPGKGYVTDMQHYQEMYQQSINEPEKFFDKMAKEYLHWDAPYTKVQSGSLNNGDVAWFLNGKLNASYNCVDRHAFANPDKPALIYEADDESDNKIITFGELLRKVSQIAGVLKSWGVKKGDTVAIYLPMIPEAVIAMLAVARIGAIHSVVFAGFSAGSLKDRVVDANSKVVITCDEGKRGGKTINTKKIVDEGLNGVDLVSRILVFQRTGTEGIPMKAGRDYWWHEEAAKQRTYLPPVSCDAEDPLFLLYTSGSTGSPKGVVHTTGGYLLGAALTTRYVFDIHPEDVLFTAGDVGWITGHTYALYGPLTLGTASIIFESTPAYPDYGRYWRIIQRHKATHFYVAPTALRLIKRVGEAEIAKYDTSSLRVLGSVGEPISPDLWEWYHEKVGNKNCVICDTMWQTESGSHLIAPLAGAVPTKPGSATVPFFGINACIIDPVTGVELEGNDVEGVLAVKSPWPSMARSVWNHHDRYMDTYLKPYPGHYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTSEIEASISNHENVSEAAVVGIPDELTGQTVVAYVSLKDGYLQNNATEGDAEHITPDNLRRELILQVRGEIGPFASPKTIILVRDLPRTRSGKIMRRVLRKVASNEAEQLGDLTTLANPEVVPAIISAVENQFFSQKKK
SIO_010081: YLR153C
subclass of: SO_0000673
so part of: YLR153C
location: complement(445524..447575)
location: region:445524-447575:-1
so has part: feature:445524-447575:-1:exon

NP_013254.1
type: Protein
SIO_000068: ncbiprotein

S000004143
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:445524-447575:-1:exon

YLR154C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RNH203
locus tag: YLR154C
so part of: sequence
location: complement(<447982..>448314)
location: region:447982-448314:-1
so has part: feature:447982-448314:-1:exon
subclass of: SO_0000010

850847
type: Gene
SIO_000068: ncbigene

position:447982:-1
position: 447982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:448314:-1
position: 448314
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447982-448314:-1:exon

YLR154C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RNH203
locus tag: YLR154C
product: Rnh203p
transcript id: NM_001182041.1
SIO_010081: YLR154C
subclass of: SO_0000673
so part of: YLR154C
location: complement(<447982..>448314)
location: region:447982-448314:-1
so has part: feature:447982-448314:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447982-448314:-1:exon

YLR154C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RNH203
locus tag: YLR154C
experiment: EXISTENCE:curator inference:GO:0043137 DNA replication, removal of RNA primer [PMID:14734815]
experiment: EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:14734815]
experiment: EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]
experiment: EXISTENCE:genetic interaction:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]
note: Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome
codon start: 1
product: Rnh203p
translation: MTKDAVNLDAYTVSFMPFYTEYQGPTEEFKDYKFEDTIYFRGKELKREKSATPSSSDNTTSNTFSNGAILSGNTITGKIVSVNNYEREGTDRNELARLQELISLIDVINQ
SIO_010081: YLR154C
subclass of: SO_0000673
so part of: YLR154C
location: complement(447982..448314)
location: region:447982-448314:-1
so has part: feature:447982-448314:-1:exon

NP_013255.1
type: Protein
SIO_000068: ncbiprotein

S000004144
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447982-448314:-1:exon

YNCL0009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0009C
so part of: sequence
location: complement(448650..448721)
location: region:448650-448721:-1
so has part: feature:448650-448721:-1:exon
subclass of: SO_0000663

850848
type: Gene
SIO_000068: ncbigene

position:448650:-1
position: 448650
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:448721:-1
position: 448721
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448650-448721:-1:exon

YNCL0009C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0009C
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCL0009C
subclass of: SO_0000673
so part of: YNCL0009C
location: complement(448650..448721)
location: region:448650-448721:-1
so has part: feature:448650-448721:-1:exon

S000006699
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:448650-448721:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 448842..449028
location: region:448842-449028:1
so has part: feature:448842-449028:1:region

S000007084
type: SGD
SIO_000068: sgd

position:448842:1
position: 448842
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:449028:1
position: 449028
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448842-449028:1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1216; Autonomously Replicating Sequence
so part of: sequence
location: 450485..450725
location: region:450485-450725:1
so has part: feature:450485-450725:1:region

S000118475
type: SGD
SIO_000068: sgd

position:450485:1
position: 450485
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:450725:1
position: 450725
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450485-450725:1:region

YNCL0010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN37-1
locus tag: YNCL0010C
so part of: sequence
location: complement(451575..458432)
location: region:451575-458432:-1
so has part: feature:451575-458432:-1:exon

9164931
type: Gene
SIO_000068: ncbigene

position:451575:-1
position: 451575
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:458432:-1
position: 458432
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451575-458432:-1:exon

YNCL0010C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: RDN37-1
locus tag: YNCL0010C
product: 35S pre-ribosomal RNA
note: 35S ribosomal RNA (35S rRNA) transcript; encoded by the RDN1 locus; processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci)
transcript id: NR_132207.1
SIO_010081: YNCL0010C
so part of: YNCL0010C
location: complement(451575..458432)
location: region:451575-458432:-1
so has part: feature:451575-458432:-1:exon

S000006486
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451575-458432:-1:exon

YNCL0011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ETS2-1
locus tag: YNCL0011C
so part of: sequence
location: complement(451575..451785)
location: region:451575-451785:-1
so has part: feature:451575-451785:-1:exon

9164936
type: Gene
SIO_000068: ncbigene

position:451785:-1
position: 451785
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451575-451785:-1:exon

YNCL0011C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ETS2-1
locus tag: YNCL0011C
product: external transcribed spacer
note: Non-coding region located adjacent to and downstream of RDN25; transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250
transcript id: NR_132208.1
SIO_010081: YNCL0011C
so part of: YNCL0011C
location: complement(451575..451785)
location: region:451575-451785:-1
so has part: feature:451575-451785:-1:exon

S000029718
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451575-451785:-1:exon

YNCL0012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN25-1
locus tag: YNCL0012C
so part of: sequence
location: complement(451786..455181)
location: region:451786-455181:-1
so has part: feature:451786-455181:-1:exon
subclass of: SO_0000573

9164935
type: Gene
SIO_000068: ncbigene

position:451786:-1
position: 451786
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:455181:-1
position: 455181
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451786-455181:-1:exon

YNCL0012C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN25-1
locus tag: YNCL0012C
product: 25S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:23673663]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:26824023]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:26824023]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:8608449]
note: 25S ribosomal RNA (25S rRNA); component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript; formed by endonucleolytic cleavage at the C2 site of internal transcribed spacer 2 (ITS2)
transcript id: NR_132209.1
SIO_010081: YNCL0012C
subclass of: SO_0000673
so part of: YNCL0012C
location: complement(451786..455181)
location: region:451786-455181:-1
so has part: feature:451786-455181:-1:exon

S000006484
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451786-455181:-1:exon

YLR154W-C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YLR154W-A
gene: TAR1
locus tag: YLR154W-C
gene synonym: YLR154W-A
so part of: sequence
location: <454696..>455070
location: region:454696-455070:1
so has part: feature:454696-455070:1:exon
subclass of: SO_0000010

850849
type: Gene
SIO_000068: ncbigene

position:454696:1
position: 454696
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:455070:1
position: 455070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454696-455070:1:exon

YLR154W-C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YLR154W-A
gene: TAR1
locus tag: YLR154W-C
gene synonym: YLR154W-A
product: Tar1p
transcript id: NM_001184514.1
SIO_010081: YLR154W-C
subclass of: SO_0000673
so part of: YLR154W-C
location: <454696..>455070
location: region:454696-455070:1
so has part: feature:454696-455070:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454696-455070:1:exon

YLR154W-C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YLR154W-A
gene: TAR1
locus tag: YLR154W-C
gene synonym: YLR154W-A
experiment: EXISTENCE:genetic interaction:GO:0043457 regulation of cellular respiration [PMID:18622616]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:12414727]
note: Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand
codon start: 1
product: Tar1p
translation: MRDSPTHKEQRAQNTMSDQMPFPFNNFTYFFTLFSKFFSSFHHCTCSLSVSRQYLALDGIYHPLRAAFPNNSTLRRHFTKNRTPRHTGFSPSMTSCSKEHRQGTAPKLPSPNYNSGTEGTRFQI
SIO_010081: YLR154W-C
subclass of: SO_0000673
so part of: YLR154W-C
location: 454696..455070
location: region:454696-455070:1
so has part: feature:454696-455070:1:exon

NP_690845.1
type: Protein
SIO_000068: ncbiprotein

S000028422
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454696-455070:1:exon

YNCL0013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITS2-1
locus tag: YNCL0013C
so part of: sequence
location: complement(455182..455413)
location: region:455182-455413:-1
so has part: feature:455182-455413:-1:exon

9164926
type: Gene
SIO_000068: ncbigene

position:455182:-1
position: 455182
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:455413:-1
position: 455413
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455182-455413:-1:exon

YNCL0013C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ITS2-1
locus tag: YNCL0013C
product: internal transcribed spacer 2
note: Non-coding region between RDN58 and RDN25; transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure that is required for processing of the precursor transcript
transcript id: NR_132210.1
SIO_010081: YNCL0013C
so part of: YNCL0013C
location: complement(455182..455413)
location: region:455182-455413:-1
so has part: feature:455182-455413:-1:exon

S000029716
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455182-455413:-1:exon

YNCL0014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN58-1
locus tag: YNCL0014C
so part of: sequence
location: complement(455414..455571)
location: region:455414-455571:-1
so has part: feature:455414-455571:-1:exon
subclass of: SO_0000573

9164934
type: Gene
SIO_000068: ncbigene

position:455414:-1
position: 455414
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:455571:-1
position: 455571
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455414-455571:-1:exon

YNCL0014C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN58-1
locus tag: YNCL0014C
product: 5.8S ribosomal RNA
note: 5.8S ribosomal RNA (5.8S rRNA); component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript; 3' end formation involves processing by the exosome complex while 5' end is generated by Kem1p and Rat1p
transcript id: NR_132211.1
SIO_010081: YNCL0014C
subclass of: SO_0000673
so part of: YNCL0014C
location: complement(455414..455571)
location: region:455414-455571:-1
so has part: feature:455414-455571:-1:exon

S000006488
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455414-455571:-1:exon

YNCL0015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITS1-1
locus tag: YNCL0015C
so part of: sequence
location: complement(455572..455932)
location: region:455572-455932:-1
so has part: feature:455572-455932:-1:exon

9164938
type: Gene
SIO_000068: ncbigene

position:455572:-1
position: 455572
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:455932:-1
position: 455932
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455572-455932:-1:exon

YNCL0015C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ITS1-1
locus tag: YNCL0015C
product: internal transcribed spacer 1
note: Non-coding region between RDN58 and RDN18; transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3'ETS)
transcript id: NR_132212.1
SIO_010081: YNCL0015C
so part of: YNCL0015C
location: complement(455572..455932)
location: region:455572-455932:-1
so has part: feature:455572-455932:-1:exon

S000029715
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455572-455932:-1:exon

YNCL0016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN18-1
locus tag: YNCL0016C
so part of: sequence
location: complement(455933..457732)
location: region:455933-457732:-1
so has part: feature:455933-457732:-1:exon
subclass of: SO_0000573

9164923
type: Gene
SIO_000068: ncbigene

position:455933:-1
position: 455933
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:457732:-1
position: 457732
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455933-457732:-1:exon

YNCL0016C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN18-1
locus tag: YNCL0016C
product: 18S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:11701127]
experiment: EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:20699223|PMID:18708582]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:18003936]
experiment: EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:18708582]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:19029250]
experiment: EXISTENCE:mutant phenotype:GO:0061770 translation elongation factor binding [PMID:19029250]
note: 18S ribosomal RNA (18S rRNA); component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript
transcript id: NR_132213.1
SIO_010081: YNCL0016C
subclass of: SO_0000673
so part of: YNCL0016C
location: complement(455933..457732)
location: region:455933-457732:-1
so has part: feature:455933-457732:-1:exon

S000006482
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455933-457732:-1:exon

YNCL0017C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ETS1-1
locus tag: YNCL0017C
so part of: sequence
location: complement(457733..458432)
location: region:457733-458432:-1
so has part: feature:457733-458432:-1:exon

9164941
type: Gene
SIO_000068: ncbigene

position:457733:-1
position: 457733
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:457733-458432:-1:exon

YNCL0017C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ETS1-1
locus tag: YNCL0017C
product: external transcribed spacer
note: Non-coding region located immediately upstream of RDN18; transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA
transcript id: NR_132214.1
SIO_010081: YNCL0017C
so part of: YNCL0017C
location: complement(457733..458432)
location: region:457733-458432:-1
so has part: feature:457733-458432:-1:exon

S000029717
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:457733-458432:-1:exon

misc_feature
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
note: NTS2-1; Non-transcribed region of the rDNA repeat; located between RND5 and the 5'ETS; contains RNA polymerase I termination site
so part of: sequence
location: complement(458433..459675)
location: region:458433-459675:-1
so has part: feature:458433-459675:-1:region

S000029329
type: SGD
SIO_000068: sgd

position:458433:-1
position: 458433
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:459675:-1
position: 459675
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458433-459675:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1200-1; Chromosomal origin of bidirectional DNA replication; an rDNA ARS is presumed to be present in each tandem rDNA repeat, but fewer than one-third of the rDNA ARSs are actually used as replication origins in a given S phase
so part of: sequence
location: 458991..459097
location: region:458991-459097:1
so has part: feature:458991-459097:1:region

S000120636
type: SGD
SIO_000068: sgd

position:458991:1
position: 458991
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:459097:1
position: 459097
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458991-459097:1:region

YNCL0018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-1
locus tag: YNCL0018W
so part of: sequence
location: 459676..459796
location: region:459676-459796:1
so has part: feature:459676-459796:1:exon
subclass of: SO_0000573

9164945
type: Gene
SIO_000068: ncbigene

position:459676:1
position: 459676
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:459796:1
position: 459796
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459676-459796:1:exon

YNCL0018W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-1
locus tag: YNCL0018W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: 5S ribosomal RNA (5S rRNA); only complete sequence of 6 repeated RDN5 alleles; able to support viability when provided as sole form of 5S rRNA; component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in translational frame fidelity; transcription is mediated by PolIII and activated by TFIIIA and TFIIIE
transcript id: NR_132215.1
SIO_010081: YNCL0018W
subclass of: SO_0000673
so part of: YNCL0018W
location: 459676..459796
location: region:459676-459796:1
so has part: feature:459676-459796:1:exon

S000006479
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459676-459796:1:exon

misc_feature
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
note: NTS1-2; Non-transcribed region of the rDNA repeat between the 3' ETS and RDN5; required for rDNA repeat expansion
so part of: sequence
location: complement(459797..460711)
location: region:459797-460711:-1
so has part: feature:459797-460711:-1:region

S000029714
type: SGD
SIO_000068: sgd

position:459797:-1
position: 459797
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:460711:-1
position: 460711
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459797-460711:-1:region

YNCL0020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN37-2
locus tag: YNCL0020C
so part of: sequence
location: complement(460712..467569)
location: region:460712-467569:-1
so has part: feature:460712-467569:-1:exon

9164920
type: Gene
SIO_000068: ncbigene

position:460712:-1
position: 460712
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:467569:-1
position: 467569
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:460712-467569:-1:exon

YNCL0020C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: RDN37-2
locus tag: YNCL0020C
product: 35S pre-ribosomal RNA
note: 35S ribosomal RNA (35S rRNA) transcript; encoded by the RDN1 locus; processed into the 25S, 18S and 5.8S rRNAs (represented by the RDN25, RDN18, and RDN58 loci)
transcript id: NR_132216.1
SIO_010081: YNCL0020C
so part of: YNCL0020C
location: complement(460712..467569)
location: region:460712-467569:-1
so has part: feature:460712-467569:-1:exon

S000006487
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:460712-467569:-1:exon

YNCL0019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ETS2-2
locus tag: YNCL0019C
so part of: sequence
location: complement(460712..460922)
location: region:460712-460922:-1
so has part: feature:460712-460922:-1:exon

9164942
type: Gene
SIO_000068: ncbigene

position:460922:-1
position: 460922
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:460712-460922:-1:exon

YNCL0019C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ETS2-2
locus tag: YNCL0019C
product: external transcribed spacer
note: Non-coding region located adjacent to RDN25; transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250
transcript id: NR_132217.1
SIO_010081: YNCL0019C
so part of: YNCL0019C
location: complement(460712..460922)
location: region:460712-460922:-1
so has part: feature:460712-460922:-1:exon

S000029713
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:460712-460922:-1:exon

YNCL0021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN25-2
locus tag: YNCL0021C
so part of: sequence
location: complement(460923..464318)
location: region:460923-464318:-1
so has part: feature:460923-464318:-1:exon
subclass of: SO_0000573

9164921
type: Gene
SIO_000068: ncbigene

position:460923:-1
position: 460923
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:464318:-1
position: 464318
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:460923-464318:-1:exon

YNCL0021C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN25-2
locus tag: YNCL0021C
product: 25S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:23673663]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:26824023]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:26824023]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:8608449]
note: 25S ribosomal RNA (25S rRNA); component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript; formed by endonucleolytic cleavage at the C2 site of internal transcribed spacer 2 (ITS2)
transcript id: NR_132218.1
SIO_010081: YNCL0021C
subclass of: SO_0000673
so part of: YNCL0021C
location: complement(460923..464318)
location: region:460923-464318:-1
so has part: feature:460923-464318:-1:exon

S000006485
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:460923-464318:-1:exon

YLR154C-G
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR154C-G
so part of: sequence
location: complement(<462522..>462671)
location: region:462522-462671:-1
so has part: feature:462522-462671:-1:exon
subclass of: SO_0000010

1466409
type: Gene
SIO_000068: ncbigene

position:462522:-1
position: 462522
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462671:-1
position: 462671
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462522-462671:-1:exon

YLR154C-G
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR154C-G
product: uncharacterized protein
transcript id: NM_001184560.1
SIO_010081: YLR154C-G
subclass of: SO_0000673
so part of: YLR154C-G
location: complement(<462522..>462671)
location: region:462522-462671:-1
so has part: feature:462522-462671:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462522-462671:-1:exon

YLR154C-G
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR154C-G
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2
codon start: 1
product: uncharacterized protein
translation: MWRRRREPWEELSFLLNSLSPRNWFIRRWGLMAGRGQHLCWLRCACDGP
SIO_010081: YLR154C-G
subclass of: SO_0000673
so part of: YLR154C-G
location: complement(462522..462671)
location: region:462522-462671:-1
so has part: feature:462522-462671:-1:exon

NP_878121.1
type: Protein
SIO_000068: ncbiprotein

S000028561
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462522-462671:-1:exon

YNCL0022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITS2-2
locus tag: YNCL0022C
so part of: sequence
location: complement(464319..464550)
location: region:464319-464550:-1
so has part: feature:464319-464550:-1:exon

9164930
type: Gene
SIO_000068: ncbigene

position:464319:-1
position: 464319
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:464550:-1
position: 464550
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464319-464550:-1:exon

YNCL0022C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ITS2-2
locus tag: YNCL0022C
product: internal transcribed spacer 2
note: Non-coding region between RDN58 and RDN25; transcribed as part of the 35S rRNA precursor transcript; forms a stem-loop structure required for processing of the precursor transcript
transcript id: NR_132219.1
SIO_010081: YNCL0022C
so part of: YNCL0022C
location: complement(464319..464550)
location: region:464319-464550:-1
so has part: feature:464319-464550:-1:exon

S000029712
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464319-464550:-1:exon

YNCL0023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN58-2
locus tag: YNCL0023C
so part of: sequence
location: complement(464551..464708)
location: region:464551-464708:-1
so has part: feature:464551-464708:-1:exon
subclass of: SO_0000573

9164939
type: Gene
SIO_000068: ncbigene

position:464551:-1
position: 464551
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:464708:-1
position: 464708
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464551-464708:-1:exon

YNCL0023C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN58-2
locus tag: YNCL0023C
product: 5.8S ribosomal RNA
note: 5.8S ribosomal RNA (5.8S rRNA); component of the large (60S) ribosomal subunit; encoded in the rDNA repeat (RDN1)
transcript id: NR_132220.1
SIO_010081: YNCL0023C
subclass of: SO_0000673
so part of: YNCL0023C
location: complement(464551..464708)
location: region:464551-464708:-1
so has part: feature:464551-464708:-1:exon

S000006489
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464551-464708:-1:exon

YNCL0024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITS1-2
locus tag: YNCL0024C
so part of: sequence
location: complement(464709..465069)
location: region:464709-465069:-1
so has part: feature:464709-465069:-1:exon

9164940
type: Gene
SIO_000068: ncbigene

position:464709:-1
position: 464709
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:465069:-1
position: 465069
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:464709-465069:-1:exon

YNCL0024C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ITS1-2
locus tag: YNCL0024C
product: internal transcribed spacer 1
note: Non-coding region between RDN58 and RDN18; transcribed as part of the 35S rRNA precursor transcript; excision during transcript maturation is coupled with processing of the 3' external transcribed spacer (3' ETS)
transcript id: NR_132221.1
SIO_010081: YNCL0024C
so part of: YNCL0024C
location: complement(464709..465069)
location: region:464709-465069:-1
so has part: feature:464709-465069:-1:exon

S000029709
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:464709-465069:-1:exon

YNCL0025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN18-2
locus tag: YNCL0025C
so part of: sequence
location: complement(465070..466869)
location: region:465070-466869:-1
so has part: feature:465070-466869:-1:exon
subclass of: SO_0000573

9164932
type: Gene
SIO_000068: ncbigene

position:465070:-1
position: 465070
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:466869:-1
position: 466869
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465070-466869:-1:exon

YNCL0025C
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN18-2
locus tag: YNCL0025C
product: 18S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:11701127]
experiment: EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:20699223|PMID:18708582]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:18003936]
experiment: EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:18708582]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:19029250]
experiment: EXISTENCE:mutant phenotype:GO:0061770 translation elongation factor binding [PMID:19029250]
note: 18S ribosomal RNA (18S rRNA); component of the small (40S) ribosomal subunit; involved in codon recognition by tRNAs or the release factor eRF1 (Sup45p); encoded in the rDNA repeat (RDN1) as part of the 35S primary transcript
transcript id: NR_132222.1
SIO_010081: YNCL0025C
subclass of: SO_0000673
so part of: YNCL0025C
location: complement(465070..466869)
location: region:465070-466869:-1
so has part: feature:465070-466869:-1:exon

S000006483
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465070-466869:-1:exon

YNCL0026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ETS1-2
locus tag: YNCL0026C
so part of: sequence
location: complement(466870..467569)
location: region:466870-467569:-1
so has part: feature:466870-467569:-1:exon

9164933
type: Gene
SIO_000068: ncbigene

position:466870:-1
position: 466870
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466870-467569:-1:exon

YNCL0026C
type: Miscellaneous RNA
subclass of: SO_0000673
RO_0002162: 559292
gene: ETS1-2
locus tag: YNCL0026C
product: external transcribed spacer
note: Non-coding region located immediately upstream of RDN18; transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA
transcript id: NR_132223.1
SIO_010081: YNCL0026C
so part of: YNCL0026C
location: complement(466870..467569)
location: region:466870-467569:-1
so has part: feature:466870-467569:-1:exon

S000029707
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466870-467569:-1:exon

misc_feature
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
note: NTS2-2; Non-transcribed region of the rDNA repeat; located between RDN5 and the 5' ETS
so part of: sequence
location: complement(467570..468812)
location: region:467570-468812:-1
so has part: feature:467570-468812:-1:region

S000029706
type: SGD
SIO_000068: sgd

position:467570:-1
position: 467570
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:468812:-1
position: 468812
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:467570-468812:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1200-2; Chromosomal origin of bidirectional DNA replication; an rDNA ARS is presumed to be present in each tandem rDNA repeat, but fewer than one-third of the rDNA ARSs are actually used as replication origins in a given S phase
so part of: sequence
location: 468128..468234
location: region:468128-468234:1
so has part: feature:468128-468234:1:region

S000120655
type: SGD
SIO_000068: sgd

position:468128:1
position: 468128
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:468234:1
position: 468234
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468128-468234:1:region

YNCL0027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-2
locus tag: YNCL0027W
so part of: sequence
location: 468813..468931
location: region:468813-468931:1
so has part: feature:468813-468931:1:exon
subclass of: SO_0000573

9164928
type: Gene
SIO_000068: ncbigene

position:468813:1
position: 468813
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:468931:1
position: 468931
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468813-468931:1:exon

YNCL0027W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-2
locus tag: YNCL0027W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: Variant 5S ribosomal rRNA (5S rRNA) gene; located within the RDN1 locus; unable to support cell viability when provided as sole source of 5S rRNA; identical in sequence to variant alleles RDN5-3, RDN5-4, and RDN5-5
transcript id: NR_132224.1
SIO_010081: YNCL0027W
subclass of: SO_0000673
so part of: YNCL0027W
location: 468813..468931
location: region:468813-468931:1
so has part: feature:468813-468931:1:exon

S000006480
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468813-468931:1:exon

YLR154C-H
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR154C-H
so part of: sequence
location: complement(<468827..>468958)
location: region:468827-468958:-1
so has part: feature:468827-468958:-1:exon
subclass of: SO_0000010

1466410
type: Gene
SIO_000068: ncbigene

position:468827:-1
position: 468827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:468958:-1
position: 468958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468827-468958:-1:exon

YLR154C-H
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR154C-H
product: uncharacterized protein
transcript id: NM_001184564.1
SIO_010081: YLR154C-H
subclass of: SO_0000673
so part of: YLR154C-H
location: complement(<468827..>468958)
location: region:468827-468958:-1
so has part: feature:468827-468958:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:468827-468958:-1:exon

YLR154C-H
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR154C-H
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MYSCAKKKTTAAPEFRVWSPTTLLGQALTSLTTVDRTGNGAFW
SIO_010081: YLR154C-H
subclass of: SO_0000673
so part of: YLR154C-H
location: complement(468827..468958)
location: region:468827-468958:-1
so has part: feature:468827-468958:-1:exon

NP_878126.1
type: Protein
SIO_000068: ncbiprotein

S000028562
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468827-468958:-1:exon

YLR155C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-1
locus tag: YLR155C
gene synonym: ASP3
so part of: sequence
location: complement(<469317..>470405)
location: region:469317-470405:-1
so has part: feature:469317-470405:-1:exon
subclass of: SO_0000010

850850
type: Gene
SIO_000068: ncbigene

position:469317:-1
position: 469317
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:470405:-1
position: 470405
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469317-470405:-1:exon

YLR155C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-1
locus tag: YLR155C
gene synonym: ASP3
product: asparaginase ASP3-1
transcript id: NM_001182042.1
SIO_010081: YLR155C
subclass of: SO_0000673
so part of: YLR155C
location: complement(<469317..>470405)
location: region:469317-470405:-1
so has part: feature:469317-470405:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469317-470405:-1:exon

YLR155C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-1
locus tag: YLR155C
gene synonym: ASP3
EC number: 3.5.1.1
experiment: EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006530 asparagine catabolic process [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]
note: Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from wine yeast Wickerhamomyces anomalus or close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3 that arose from a segmental duplication
codon start: 1
product: asparaginase ASP3-1
translation: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
SIO_010081: YLR155C
subclass of: SO_0000673
so part of: YLR155C
location: complement(469317..470405)
location: region:469317-470405:-1
so has part: feature:469317-470405:-1:exon

NP_013256.1
type: Protein
SIO_000068: ncbiprotein

S000004145
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469317-470405:-1:exon

YLR156W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR156W
so part of: sequence
location: <472113..>472457
location: region:472113-472457:1
so has part: feature:472113-472457:1:exon
subclass of: SO_0000010

850851
type: Gene
SIO_000068: ncbigene

position:472113:1
position: 472113
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472457:1
position: 472457
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472113-472457:1:exon

YLR156W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR156W
product: uncharacterized protein
transcript id: NM_001182043.1
SIO_010081: YLR156W
subclass of: SO_0000673
so part of: YLR156W
location: <472113..>472457
location: region:472113-472457:1
so has part: feature:472113-472457:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472113-472457:1:exon

YLR156W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR156W
note: hypothetical protein; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MKFQYALAKEQLGSNSRSGVKKLISKHHWLPEYYFSDLSFSVVQQWDSRAIEKTTIISCMRPANQEIYPLRHCETLRSQPCSLFSSLYARSFQSSCTLHVAEPSPGFHMYGCHT
SIO_010081: YLR156W
subclass of: SO_0000673
so part of: YLR156W
location: 472113..472457
location: region:472113-472457:1
so has part: feature:472113-472457:1:exon

NP_757337.1
type: Protein
SIO_000068: ncbiprotein

S000004146
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472113-472457:1:exon

YNCL0028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-3
locus tag: YNCL0028W
so part of: sequence
location: 472465..472583
location: region:472465-472583:1
so has part: feature:472465-472583:1:exon
subclass of: SO_0000573

9164924
type: Gene
SIO_000068: ncbigene

position:472465:1
position: 472465
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:472583:1
position: 472583
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472465-472583:1:exon

YNCL0028W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-3
locus tag: YNCL0028W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: Variant 5S ribosomal RNA (5S rRNA) gene; located at a site distal to the RDN1 locus; unable to support cell viability when provided as sole source of 5S rRNA; identical in sequence to variant alleles RDN5-2, RDN5-4, and RDN5-5
transcript id: NR_132225.1
SIO_010081: YNCL0028W
subclass of: SO_0000673
so part of: YNCL0028W
location: 472465..472583
location: region:472465-472583:1
so has part: feature:472465-472583:1:exon

S000006481
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472465-472583:1:exon

YLR156C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR156C-A
so part of: sequence
location: complement(<472479..>472610)
location: region:472479-472610:-1
so has part: feature:472479-472610:-1:exon
subclass of: SO_0000010

1466411
type: Gene
SIO_000068: ncbigene

position:472479:-1
position: 472479
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472610:-1
position: 472610
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472479-472610:-1:exon

YLR156C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR156C-A
product: uncharacterized protein
transcript id: NM_001184563.1
SIO_010081: YLR156C-A
subclass of: SO_0000673
so part of: YLR156C-A
location: complement(<472479..>472610)
location: region:472479-472610:-1
so has part: feature:472479-472610:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472479-472610:-1:exon

YLR156C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR156C-A
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MYSCAKKKTTAAPEFRVWSPTTLLGQALTSLTTVDRTGNGAFW
SIO_010081: YLR156C-A
subclass of: SO_0000673
so part of: YLR156C-A
location: complement(472479..472610)
location: region:472479-472610:-1
so has part: feature:472479-472610:-1:exon

NP_878123.1
type: Protein
SIO_000068: ncbiprotein

S000028564
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472479-472610:-1:exon

YLR157C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-2
locus tag: YLR157C
gene synonym: ASP3
so part of: sequence
location: complement(<472969..>474057)
location: region:472969-474057:-1
so has part: feature:472969-474057:-1:exon
subclass of: SO_0000010

850852
type: Gene
SIO_000068: ncbigene

position:472969:-1
position: 472969
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:474057:-1
position: 474057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472969-474057:-1:exon

YLR157C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-2
locus tag: YLR157C
gene synonym: ASP3
product: asparaginase ASP3-2
transcript id: NM_001182044.1
SIO_010081: YLR157C
subclass of: SO_0000673
so part of: YLR157C
location: complement(<472969..>474057)
location: region:472969-474057:-1
so has part: feature:472969-474057:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472969-474057:-1:exon

YLR157C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-2
locus tag: YLR157C
gene synonym: ASP3
EC number: 3.5.1.1
experiment: EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]
experiment: EXISTENCE:direct assay:GO:0006530 asparagine catabolic process [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]
note: Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication
codon start: 1
product: asparaginase ASP3-2
translation: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
SIO_010081: YLR157C
subclass of: SO_0000673
so part of: YLR157C
location: complement(472969..474057)
location: region:472969-474057:-1
so has part: feature:472969-474057:-1:exon

NP_013258.1
type: Protein
SIO_000068: ncbiprotein

S000004147
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472969-474057:-1:exon

YLR157W-D
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YLR157W-A
locus tag: YLR157W-D
gene synonym: YLR157W-A
so part of: sequence
location: <475764..>475976
location: region:475764-475976:1
so has part: feature:475764-475976:1:exon
subclass of: SO_0000010

1466412
type: Gene
SIO_000068: ncbigene

position:475764:1
position: 475764
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475976:1
position: 475976
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475764-475976:1:exon

YLR157W-D
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YLR157W-A
locus tag: YLR157W-D
gene synonym: YLR157W-A
product: uncharacterized protein
transcript id: NM_001184608.1
SIO_010081: YLR157W-D
subclass of: SO_0000673
so part of: YLR157W-D
location: <475764..>475976
location: region:475764-475976:1
so has part: feature:475764-475976:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:475764-475976:1:exon

YLR157W-D
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YLR157W-A
locus tag: YLR157W-D
gene synonym: YLR157W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MKFQYALAKEQLGSNSRSGVKKLISKHHWLPEYYFSDLSFSVVQQWDSRAIEKTTIISCMRPANQEIYPL
SIO_010081: YLR157W-D
subclass of: SO_0000673
so part of: YLR157W-D
location: 475764..475976
location: region:475764-475976:1
so has part: feature:475764-475976:1:exon

NP_878124.1
type: Protein
SIO_000068: ncbiprotein

S000028677
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475764-475976:1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YLRCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YLRCTy1-1
so part of: sequence
location: complement(475976..481897)
location: region:475976-481897:-1
so has part: feature:475976-481897:-1:region

S000007081
type: SGD
SIO_000068: sgd

position:475976:-1
position: 475976
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:481897:-1
position: 481897
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475976-481897:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(475976..476310)
location: region:475976-476310:-1
so has part: feature:475976-476310:-1:region

S000007068
type: SGD
SIO_000068: sgd

position:476310:-1
position: 476310
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475976-476310:-1:region

YLR157C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR157C-B
so part of: sequence
location: complement(<476333..>481601)
location: region:476333-481601:-1
so has part: feature:476333-481601:-1:exon
subclass of: SO_0000010

850853
type: Gene
SIO_000068: ncbigene

position:476333:-1
position: 476333
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:481601:-1
position: 481601
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476333-481601:-1:exon

YLR157C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR157C-B
product: gag-pol fusion protein
transcript id: NM_001184406.2
SIO_010081: YLR157C-B
subclass of: SO_0000673
so part of: YLR157C-B
location: complement(<476333..>481601)
location: region:476333-481601:-1
so has part: feature:476333-481601:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476333-481601:-1:exon

YLR157C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR157C-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAPTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YLR157C-B
subclass of: SO_0000673
so part of: YLR157C-B
location: complement(join(476333..480295,480297..481601))
location: region:476333-481601:-1
so has part: feature:480297-481601:-1:exon
so has part: feature:476333-480295:-1:exon

NP_058169.1
type: Protein
SIO_000068: ncbiprotein

S000007374
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:480297-481601:-1:exon

position:480297:-1
position: 480297
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:476333-480295:-1:exon

position:480295:-1
position: 480295
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR157C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR157C-A
so part of: sequence
location: complement(<480279..>481601)
location: region:480279-481601:-1
so has part: feature:480279-481601:-1:exon
subclass of: SO_0000010

850854
type: Gene
SIO_000068: ncbigene

position:480279:-1
position: 480279
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:480279-481601:-1:exon

YLR157C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR157C-A
product: gag protein
transcript id: NM_001184405.1
SIO_010081: YLR157C-A
subclass of: SO_0000673
so part of: YLR157C-A
location: complement(<480279..>481601)
location: region:480279-481601:-1
so has part: feature:480279-481601:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:480279-481601:-1:exon

YLR157C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR157C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YLR157C-A
subclass of: SO_0000673
so part of: YLR157C-A
location: complement(480279..481601)
location: region:480279-481601:-1
so has part: feature:480279-481601:-1:exon

NP_058170.1
type: Protein
SIO_000068: ncbiprotein

S000007373
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:480279-481601:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(481563..481897)
location: region:481563-481897:-1
so has part: feature:481563-481897:-1:region

S000007069
type: SGD
SIO_000068: sgd

position:481563:-1
position: 481563
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:481563-481897:-1:region

YLR157W-E
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YLR157W-B
alternative label: YLR157W-C
locus tag: YLR157W-E
gene synonym: YLR157W-B; YLR157W-C
so part of: sequence
location: <481873..>482037
location: region:481873-482037:1
so has part: feature:481873-482037:1:exon
subclass of: SO_0000010

1466413
type: Gene
SIO_000068: ncbigene

position:481873:1
position: 481873
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482037:1
position: 482037
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:481873-482037:1:exon

YLR157W-E
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YLR157W-B
alternative label: YLR157W-C
locus tag: YLR157W-E
gene synonym: YLR157W-B; YLR157W-C
product: uncharacterized protein
transcript id: NM_001184609.1
SIO_010081: YLR157W-E
subclass of: SO_0000673
so part of: YLR157W-E
location: <481873..>482037
location: region:481873-482037:1
so has part: feature:481873-482037:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:481873-482037:1:exon

YLR157W-E
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YLR157W-B
alternative label: YLR157W-C
locus tag: YLR157W-E
gene synonym: YLR157W-B; YLR157W-C
note: hypothetical protein identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element
codon start: 1
product: uncharacterized protein
translation: MIVDFYSNTLRHCETLRSQPCSLFSSLYARSFQSSCTLHVAEPSPGFHMYGCHT
SIO_010081: YLR157W-E
subclass of: SO_0000673
so part of: YLR157W-E
location: 481873..482037
location: region:481873-482037:1
so has part: feature:481873-482037:1:exon

NP_878125.1
type: Protein
SIO_000068: ncbiprotein

S000028678
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:481873-482037:1:exon

YNCL0029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-4
locus tag: YNCL0029W
so part of: sequence
location: 482045..482163
location: region:482045-482163:1
so has part: feature:482045-482163:1:exon
subclass of: SO_0000573

9164929
type: Gene
SIO_000068: ncbigene

position:482045:1
position: 482045
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:482163:1
position: 482163
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482045-482163:1:exon

YNCL0029W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-4
locus tag: YNCL0029W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: Variant 5S ribosomal rRNA (5S rRNA) gene; located at a site distal to the RDN1 locus; unable to support cell viability when provided as sole source of 5S rRNA; identical in sequence to variant alleles RDN5-2, RDN5-3, and RDN5-5
transcript id: NR_132226.1
SIO_010081: YNCL0029W
subclass of: SO_0000673
so part of: YNCL0029W
location: 482045..482163
location: region:482045-482163:1
so has part: feature:482045-482163:1:exon

S000029708
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482045-482163:1:exon

YLR157C-C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR157C-C
so part of: sequence
location: complement(<482059..>482190)
location: region:482059-482190:-1
so has part: feature:482059-482190:-1:exon
subclass of: SO_0000010

1466414
type: Gene
SIO_000068: ncbigene

position:482059:-1
position: 482059
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482190:-1
position: 482190
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482059-482190:-1:exon

YLR157C-C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR157C-C
product: uncharacterized protein
transcript id: NM_001184561.1
SIO_010081: YLR157C-C
subclass of: SO_0000673
so part of: YLR157C-C
location: complement(<482059..>482190)
location: region:482059-482190:-1
so has part: feature:482059-482190:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482059-482190:-1:exon

YLR157C-C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR157C-C
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MYSCAKKKTTAAPEFRVWSPTTLLGQALTSLTTVDRTGNGAFW
SIO_010081: YLR157C-C
subclass of: SO_0000673
so part of: YLR157C-C
location: complement(482059..482190)
location: region:482059-482190:-1
so has part: feature:482059-482190:-1:exon

NP_878122.1
type: Protein
SIO_000068: ncbiprotein

S000028565
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482059-482190:-1:exon

YLR158C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-3
locus tag: YLR158C
gene synonym: ASP3
so part of: sequence
location: complement(<482549..>483637)
location: region:482549-483637:-1
so has part: feature:482549-483637:-1:exon
subclass of: SO_0000010

850855
type: Gene
SIO_000068: ncbigene

position:482549:-1
position: 482549
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483637:-1
position: 483637
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482549-483637:-1:exon

YLR158C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-3
locus tag: YLR158C
gene synonym: ASP3
product: asparaginase ASP3-3
transcript id: NM_001182045.1
SIO_010081: YLR158C
subclass of: SO_0000673
so part of: YLR158C
location: complement(<482549..>483637)
location: region:482549-483637:-1
so has part: feature:482549-483637:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482549-483637:-1:exon

YLR158C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-3
locus tag: YLR158C
gene synonym: ASP3
EC number: 3.5.1.1
experiment: EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]
experiment: EXISTENCE:direct assay:GO:0006530 asparagine catabolic process [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]
note: Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication
codon start: 1
product: asparaginase ASP3-3
translation: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
SIO_010081: YLR158C
subclass of: SO_0000673
so part of: YLR158C
location: complement(482549..483637)
location: region:482549-483637:-1
so has part: feature:482549-483637:-1:exon

NP_013259.1
type: Protein
SIO_000068: ncbiprotein

S000004148
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482549-483637:-1:exon

YLR159W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR159W
so part of: sequence
location: <485345..>485689
location: region:485345-485689:1
so has part: feature:485345-485689:1:exon
subclass of: SO_0000010

850856
type: Gene
SIO_000068: ncbigene

position:485345:1
position: 485345
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485689:1
position: 485689
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485345-485689:1:exon

YLR159W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR159W
product: uncharacterized protein
transcript id: NM_001182046.1
SIO_010081: YLR159W
subclass of: SO_0000673
so part of: YLR159W
location: <485345..>485689
location: region:485345-485689:1
so has part: feature:485345-485689:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485345-485689:1:exon

YLR159W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR159W
note: hypothetical protein; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MKFQYALAKEQLGSNSRSGVKKLISKHHWLPEYYFSDLSFSVVQQWDSRAIEKTTIISCMRPANQEIYPLRHCETLRSQPCSLFSSLYARSFQSSCTLHVAEPSPGFHMYGCHT
SIO_010081: YLR159W
subclass of: SO_0000673
so part of: YLR159W
location: 485345..485689
location: region:485345-485689:1
so has part: feature:485345-485689:1:exon

NP_757338.1
type: Protein
SIO_000068: ncbiprotein

S000004149
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485345-485689:1:exon

YNCL0030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-5
locus tag: YNCL0030W
so part of: sequence
location: 485697..485815
location: region:485697-485815:1
so has part: feature:485697-485815:1:exon
subclass of: SO_0000573

9164946
type: Gene
SIO_000068: ncbigene

position:485697:1
position: 485697
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:485815:1
position: 485815
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485697-485815:1:exon

YNCL0030W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-5
locus tag: YNCL0030W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: Variant 5S ribosomal rRNA (5S rRNA) gene; located at a site distal to the RDN1 locus; unable to support cell viability when provided as sole source of 5S rRNA; identical in sequence to variant alleles RDN5-2, RDN5-3, and RDN5-4
transcript id: NR_132227.1
SIO_010081: YNCL0030W
subclass of: SO_0000673
so part of: YNCL0030W
location: 485697..485815
location: region:485697-485815:1
so has part: feature:485697-485815:1:exon

S000029710
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485697-485815:1:exon

YLR159C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR159C-A
so part of: sequence
location: complement(<485711..>485842)
location: region:485711-485842:-1
so has part: feature:485711-485842:-1:exon
subclass of: SO_0000010

1466415
type: Gene
SIO_000068: ncbigene

position:485711:-1
position: 485711
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485842:-1
position: 485842
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485711-485842:-1:exon

YLR159C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR159C-A
product: uncharacterized protein
transcript id: NM_001184565.1
SIO_010081: YLR159C-A
subclass of: SO_0000673
so part of: YLR159C-A
location: complement(<485711..>485842)
location: region:485711-485842:-1
so has part: feature:485711-485842:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485711-485842:-1:exon

YLR159C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR159C-A
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MYSCAKKKTTAAPEFRVWSPTTLLGQALTSLTTVDRTGNGAFW
SIO_010081: YLR159C-A
subclass of: SO_0000673
so part of: YLR159C-A
location: complement(485711..485842)
location: region:485711-485842:-1
so has part: feature:485711-485842:-1:exon

NP_878127.1
type: Protein
SIO_000068: ncbiprotein

S000028566
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485711-485842:-1:exon

YLR160C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-4
locus tag: YLR160C
gene synonym: ASP3
so part of: sequence
location: complement(<486201..>487289)
location: region:486201-487289:-1
so has part: feature:486201-487289:-1:exon
subclass of: SO_0000010

850857
type: Gene
SIO_000068: ncbigene

position:486201:-1
position: 486201
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:487289:-1
position: 487289
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486201-487289:-1:exon

YLR160C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-4
locus tag: YLR160C
gene synonym: ASP3
product: asparaginase ASP3-4
transcript id: NM_001182047.1
SIO_010081: YLR160C
subclass of: SO_0000673
so part of: YLR160C
location: complement(<486201..>487289)
location: region:486201-487289:-1
so has part: feature:486201-487289:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486201-487289:-1:exon

YLR160C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ASP3
gene: ASP3-4
locus tag: YLR160C
gene synonym: ASP3
EC number: 3.5.1.1
experiment: EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]
experiment: EXISTENCE:direct assay:GO:0006530 asparagine catabolic process [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]
experiment: EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication
codon start: 1
product: asparaginase ASP3-4
translation: MRSLNTLLLSLFVAMSSGAPLLKIREEKNSSLPSIKIFGTGGTIASKGSTSATTAGYSVGLTVNDLIEAVPSLAEKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDDYAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGRGTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTDPSEIPEVIILYSYQGLNPELIVKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQLYEEYGIPIVHSRRTADGTVPPDDAPEYAIGSGYLNPQKSRILLQLCLYSGYGMDQIRSVFSGVYGG
SIO_010081: YLR160C
subclass of: SO_0000673
so part of: YLR160C
location: complement(486201..487289)
location: region:486201-487289:-1
so has part: feature:486201-487289:-1:exon

NP_013261.1
type: Protein
SIO_000068: ncbiprotein

S000004150
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486201-487289:-1:exon

YLR161W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR161W
so part of: sequence
location: <488997..>489341
location: region:488997-489341:1
so has part: feature:488997-489341:1:exon
subclass of: SO_0000010

850858
type: Gene
SIO_000068: ncbigene

position:488997:1
position: 488997
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:489341:1
position: 489341
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488997-489341:1:exon

YLR161W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR161W
product: uncharacterized protein
transcript id: NM_001182048.1
SIO_010081: YLR161W
subclass of: SO_0000673
so part of: YLR161W
location: <488997..>489341
location: region:488997-489341:1
so has part: feature:488997-489341:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488997-489341:1:exon

YLR161W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR161W
note: hypothetical protein; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MKFQYALAKEQLGSNSRSGVKKLISKHHWLPEYYFSDLSFSVVQQWDSRAIEKTTIISCMRPANQEIYPLRHCETLRSQPCSLFSSLYARSFQSSCTLHVAEPSPGFHMYGCHT
SIO_010081: YLR161W
subclass of: SO_0000673
so part of: YLR161W
location: 488997..489341
location: region:488997-489341:1
so has part: feature:488997-489341:1:exon

NP_757339.1
type: Protein
SIO_000068: ncbiprotein

S000004151
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488997-489341:1:exon

YNCL0031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RDN5-6
locus tag: YNCL0031W
so part of: sequence
location: 489349..489469
location: region:489349-489469:1
so has part: feature:489349-489469:1:exon
subclass of: SO_0000573

9164918
type: Gene
SIO_000068: ncbigene

position:489349:1
position: 489349
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:489469:1
position: 489469
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:489349-489469:1:exon

YNCL0031W
type: Ribosomal RNA
subclass of: SO_0000252
RO_0002162: 559292
gene: RDN5-6
locus tag: YNCL0031W
product: 5S ribosomal RNA
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:16047201]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:16047201]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16047201]
note: Variant 5S ribosomal rRNA (5S rRNA) gene; located at a site distal to the RDN1 locus
transcript id: NR_132228.1
SIO_010081: YNCL0031W
subclass of: SO_0000673
so part of: YNCL0031W
location: 489349..489469
location: region:489349-489469:1
so has part: feature:489349-489469:1:exon

S000029711
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:489349-489469:1:exon

YLR162W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR162W
so part of: sequence
location: <489573..>489929
location: region:489573-489929:1
so has part: feature:489573-489929:1:exon
subclass of: SO_0000010

850859
type: Gene
SIO_000068: ncbigene

position:489573:1
position: 489573
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:489929:1
position: 489929
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:489573-489929:1:exon

YLR162W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR162W
product: uncharacterized protein
transcript id: NM_001182049.1
SIO_010081: YLR162W
subclass of: SO_0000673
so part of: YLR162W
location: <489573..>489929
location: region:489573-489929:1
so has part: feature:489573-489929:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:489573-489929:1:exon

YLR162W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR162W
note: hypothetical protein; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride
codon start: 1
product: uncharacterized protein
translation: MQHTLTRTASLPERSSSAHSAATALPALRRPPDSCETLVPLLCIFWFVFVSMSPLPPARANKSDNKGLISADRNNKATLLLTIPRCTSKSYTNDLSPLKMTLLSAGKHPRPFRQEHRC
SIO_010081: YLR162W
subclass of: SO_0000673
so part of: YLR162W
location: 489573..489929
location: region:489573-489929:1
so has part: feature:489573-489929:1:exon

NP_013263.1
type: Protein
SIO_000068: ncbiprotein

S000004152
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:489573-489929:1:exon

YLR162W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRT15
locus tag: YLR162W-A
so part of: sequence
location: <490406..>490594
location: region:490406-490594:1
so has part: feature:490406-490594:1:exon
subclass of: SO_0000010

1466416
type: Gene
SIO_000068: ncbigene

position:490406:1
position: 490406
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490594:1
position: 490594
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490406-490594:1:exon

YLR162W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRT15
locus tag: YLR162W-A
product: Rrt15p
transcript id: NM_001184566.1
SIO_010081: YLR162W-A
subclass of: SO_0000673
so part of: YLR162W-A
location: <490406..>490594
location: region:490406-490594:1
so has part: feature:490406-490594:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490406-490594:1:exon

YLR162W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRT15
locus tag: YLR162W-A
note: hypothetical protein; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription
codon start: 1
product: Rrt15p
translation: MVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRYRLTDVPPQPNSPGEIYCFYINCIMNRR
SIO_010081: YLR162W-A
subclass of: SO_0000673
so part of: YLR162W-A
location: 490406..490594
location: region:490406-490594:1
so has part: feature:490406-490594:1:exon

NP_878128.1
type: Protein
SIO_000068: ncbiprotein

S000028567
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490406-490594:1:exon

YLR163C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MIF1
gene: MAS1
locus tag: YLR163C
gene synonym: MIF1
so part of: sequence
location: complement(<491866..>493254)
location: region:491866-493254:-1
so has part: feature:491866-493254:-1:exon
subclass of: SO_0000010

850860
type: Gene
SIO_000068: ncbigene

position:491866:-1
position: 491866
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:493254:-1
position: 493254
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491866-493254:-1:exon

YLR163C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MIF1
gene: MAS1
locus tag: YLR163C
gene synonym: MIF1
product: mitochondrial processing peptidase
transcript id: NM_001182050.1
SIO_010081: YLR163C
subclass of: SO_0000673
so part of: YLR163C
location: complement(<491866..>493254)
location: region:491866-493254:-1
so has part: feature:491866-493254:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491866-493254:-1:exon

YLR163C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MIF1
gene: MAS1
locus tag: YLR163C
gene synonym: MIF1
EC number: 3.4.24.64
experiment: EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:2905264]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:2007593]
experiment: EXISTENCE:direct assay:GO:0017087 mitochondrial processing peptidase complex [PMID:2905264]
note: Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
codon start: 1
product: mitochondrial processing peptidase
translation: MFSRTASKFRNTRRLLSTISSQIPGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRSQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEITYKDQPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKLVQYAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIAIALEGVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSLANSYMSFSTSYADSGLWGMYIVTDSNEHNVQLIVNEILKEWKRIKSGKISDAEVNRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVDKITKDDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ
SIO_010081: YLR163C
subclass of: SO_0000673
so part of: YLR163C
location: complement(491866..493254)
location: region:491866-493254:-1
so has part: feature:491866-493254:-1:exon

NP_013264.1
type: Protein
SIO_000068: ncbiprotein

S000004153
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491866-493254:-1:exon

YLR164W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHH4
locus tag: YLR164W
so part of: sequence
location: <493883..>494389
location: region:493883-494389:1
so has part: feature:493883-494389:1:exon
subclass of: SO_0000010

850861
type: Gene
SIO_000068: ncbigene

position:493883:1
position: 493883
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:494389:1
position: 494389
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:493883-494389:1:exon

YLR164W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHH4
locus tag: YLR164W
product: protein SHH4
transcript id: NM_001182051.1
SIO_010081: YLR164W
subclass of: SO_0000673
so part of: YLR164W
location: <493883..>494389
location: region:493883-494389:1
so has part: feature:493883-494389:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:493883-494389:1:exon

YLR164W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHH4
locus tag: YLR164W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10637294]
experiment: EXISTENCE:genetic interaction:GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [PMID:25328978]
experiment: EXISTENCE:genetic interaction:GO:0006121 mitochondrial electron transport, succinate to ubiquinone [PMID:25328978]
experiment: EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:25328978]
note: Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p
codon start: 1
product: protein SHH4
translation: MSSTKFLKPLCRIRAFHTSIARSFTIPFLPKIPQKPGGVSGTANDSSYMPPESRAQGSYHWIVERGLSLAVLPLIAVPLVTTGPISTFTDTFLSLVLLGHCHIGFQSCIIDYISERVYGKVHHYAMYLLSLGSFLSFVGIYKLESQEAGLIASLKSLWDNKPVEKKRQ
SIO_010081: YLR164W
subclass of: SO_0000673
so part of: YLR164W
location: 493883..494389
location: region:493883-494389:1
so has part: feature:493883-494389:1:exon

NP_013265.1
type: Protein
SIO_000068: ncbiprotein

S000004154
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:493883-494389:1:exon

YLR165C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUS5
locus tag: YLR165C
so part of: sequence
location: complement(<494494..>495258)
location: region:494494-495258:-1
so has part: feature:494494-495258:-1:exon
subclass of: SO_0000010

850862
type: Gene
SIO_000068: ncbigene

position:494494:-1
position: 494494
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:495258:-1
position: 495258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494494-495258:-1:exon

YLR165C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUS5
locus tag: YLR165C
product: pseudouridine synthase PUS5
transcript id: NM_001182052.1
SIO_010081: YLR165C
subclass of: SO_0000673
so part of: YLR165C
location: complement(<494494..>495258)
location: region:494494-495258:-1
so has part: feature:494494-495258:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494494-495258:-1:exon

YLR165C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUS5
locus tag: YLR165C
EC number: 5.4.99.43
experiment: EXISTENCE:mutant phenotype:GO:0000154 rRNA modification [PMID:10756195]
experiment: EXISTENCE:mutant phenotype:GO:0001522 pseudouridine synthesis [PMID:10756195]
experiment: EXISTENCE:mutant phenotype:GO:0004730 pseudouridylate synthase activity [PMID:10756195]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10756195]
note: Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
codon start: 1
product: pseudouridine synthase PUS5
translation: MSLKKQIPIIFENTHYFIVNKPPGIPSQPPDCRTWGRTHPNLDPTPLLERFKAIYYSHREVELCRTVHRLDHCVTGGMLIAKTKDGSVKFSRFLQKGGNNGYKLQRKYVAIVESSGRFNKPNNYEIKYGPKYNFLISHGGREITKFKEVDENCIVLQLVTGKKHQIRNHVSQILNQPILNDKRHGSTVNFPELFNDQIALHSACIITKIGLQTKTHLIPMEHNNTGQLWSRKYVNEEGEFTLPIKEVLLENWDQ
SIO_010081: YLR165C
subclass of: SO_0000673
so part of: YLR165C
location: complement(494494..495258)
location: region:494494-495258:-1
so has part: feature:494494-495258:-1:exon

NP_013266.1
type: Protein
SIO_000068: ncbiprotein

S000004155
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494494-495258:-1:exon

YLR166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC10
locus tag: YLR166C
so part of: sequence
location: complement(<495429..>498044)
location: region:495429-498044:-1
so has part: feature:495429-498044:-1:exon
subclass of: SO_0000010

850863
type: Gene
SIO_000068: ncbigene

position:495429:-1
position: 495429
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498044:-1
position: 498044
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:495429-498044:-1:exon

YLR166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC10
locus tag: YLR166C
product: exocyst subunit SEC10
transcript id: NM_001182053.1
SIO_010081: YLR166C
subclass of: SO_0000673
so part of: YLR166C
location: complement(<495429..>498044)
location: region:495429-498044:-1
so has part: feature:495429-498044:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:495429-498044:-1:exon

YLR166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC10
locus tag: YLR166C
experiment: EXISTENCE:curator inference:GO:0090522 vesicle tethering involved in exocytosis [PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]
experiment: EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
note: Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion
codon start: 1
product: exocyst subunit SEC10
translation: MNSLYELDPKWKKLLKTDNFLGGLTVNEFVQELSKDHRNDVLIDANTKNLPTNEKDQDAIREAIWKQLDPKPYIRTFESTLKELKNLNEETLNKRQYFSEQVATQEVIHSENVIKLSKDLHTTLLTFDKLDDRLTNVTQVVSPLGDKLETAIKKKQNYIQSVELIRRYNDFYSMGKSDIVEQLRLSKNWKLNLKSVKLMKNLLILSSKLETSSIPKTINTKLVIEKYSEMMENELLENFNSAYRENNFTKLNEIAIILNNFNGGVNVIQSFINQHDYFIDTKQIDLENEFENVFIKNVKFKEQLIDFENHSVIIETSMQNLINDVETVIKNESKIVKRVFEEKATHVIQLFIQRVFAQKIEPRFEVLLRNSLSISNLAYVRILHGLFTLFGKFTKSLIDYFQLLEIDDSNQILSTTLEQCFADLFSHYLYDRSKYFGIEKRSLEAILVDMTSKFTVNYDKEINKRVLLDKYKEKLSTNVDAFMHSPRGNTHSRQDSTSRSKLSQFNSFLKTHLDKDHLSLNRTNTLSDSFNNSSSSTQYDVANNSSSLVNSSFTASDIDNSPNSPANYSLNDVDSMLKCVVESTARVMELIPNKAHLYILEILKIMFLGIVDSYMEIALEVAYWKICKVDINKTAGVVNLNFLKFISMSTEILDLLSISIKSIFLPLLNNSPEIKAQIIEMTNSQIQKMEILINIILQETITVISTKFSAILCKQKKKDFVPKSQELLDQDTLPAIEIVNILNLIFEQSSKFLKGKNLQTFLTLIGEELYGLLLSHYSHFQVNSIGGVVVTKDIIGYQTAIEDWGVASLIDKFATLRELANLFTVQPELLESLTKEGHLADIGRDIIQSYISNREDFNHDNFINSVKLNFR
SIO_010081: YLR166C
subclass of: SO_0000673
so part of: YLR166C
location: complement(495429..498044)
location: region:495429-498044:-1
so has part: feature:495429-498044:-1:exon

NP_013267.1
type: Protein
SIO_000068: ncbiprotein

S000004156
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:495429-498044:-1:exon

YLR167W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS37
alternative label: UBI3
gene: RPS31
locus tag: YLR167W
gene synonym: RPS37; UBI3
so part of: sequence
location: <498947..>499405
location: region:498947-499405:1
so has part: feature:498947-499405:1:exon
subclass of: SO_0000010

850864
type: Gene
SIO_000068: ncbigene

position:498947:1
position: 498947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499405:1
position: 499405
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498947-499405:1:exon

YLR167W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS37
alternative label: UBI3
gene: RPS31
locus tag: YLR167W
gene synonym: RPS37; UBI3
product: ubiquitin-ribosomal 40S subunit protein S31 fusion protein
transcript id: NM_001182054.1
SIO_010081: YLR167W
subclass of: SO_0000673
so part of: YLR167W
location: <498947..>499405
location: region:498947-499405:1
so has part: feature:498947-499405:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:498947-499405:1:exon

YLR167W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS37
alternative label: UBI3
gene: RPS31
locus tag: YLR167W
gene synonym: RPS37; UBI3
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:18782943|PMID:385049]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:18782943|PMID:385049]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:385049|PMID:18782943]
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9830035]
experiment: EXISTENCE:mutant phenotype:GO:0002109 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [PMID:2538753]
experiment: EXISTENCE:mutant phenotype:GO:0031386 protein tag [PMID:2538753]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:32408794]
note: Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
codon start: 1
product: ubiquitin-ribosomal 40S subunit protein S31 fusion protein
translation: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKVKLAVLSYYKVDAEGKVTKLRRECSNPTCGAGVFLANHKDRLYCGKCHSVYKVNA
SIO_010081: YLR167W
subclass of: SO_0000673
so part of: YLR167W
location: 498947..499405
location: region:498947-499405:1
so has part: feature:498947-499405:1:exon

NP_013268.1
type: Protein
SIO_000068: ncbiprotein

S000004157
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:498947-499405:1:exon

YLR168C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM30
alternative label: GEP1
alternative label: MSF1
alternative label: MSF1'
gene: UPS2
locus tag: YLR168C
gene synonym: AIM30; GEP1; MSF1; MSF1'
so part of: sequence
location: complement(<499578..>500270)
location: region:499578-500270:-1
so has part: feature:499578-500270:-1:exon
subclass of: SO_0000010

850865
type: Gene
SIO_000068: ncbigene

position:499578:-1
position: 499578
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:500270:-1
position: 500270
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499578-500270:-1:exon

YLR168C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM30
alternative label: GEP1
alternative label: MSF1
alternative label: MSF1'
gene: UPS2
locus tag: YLR168C
gene synonym: AIM30; GEP1; MSF1; MSF1'
product: Ups2p
transcript id: NM_001182055.1
SIO_010081: YLR168C
subclass of: SO_0000673
so part of: YLR168C
location: complement(<499578..>500270)
location: region:499578-500270:-1
so has part: feature:499578-500270:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499578-500270:-1:exon

YLR168C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM30
alternative label: GEP1
alternative label: MSF1
alternative label: MSF1'
gene: UPS2
locus tag: YLR168C
gene synonym: AIM30; GEP1; MSF1; MSF1'
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19506038]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:27354379]
experiment: EXISTENCE:genetic interaction:GO:0032048 cardiolipin metabolic process [PMID:19506038]
experiment: EXISTENCE:genetic interaction:GO:0042407 cristae formation [PMID:19221197]
experiment: EXISTENCE:genetic interaction:GO:0046337 phosphatidylethanolamine metabolic process [PMID:19221197]
experiment: EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19221197]
experiment: EXISTENCE:mutant phenotype:GO:0046337 phosphatidylethanolamine metabolic process [PMID:19221197]
experiment: EXISTENCE:mutant phenotype:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:22403410]
note: Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication
codon start: 1
product: Ups2p
translation: MKLFQNSYDFNYPWDQVTAANWKKYPNEISTHVIAVDVLRRELKDQGKVLVTERLITVKQGVPKWIMMMLGGTNMSHVREVSVVDLNKKSLTMRSCNLTMCNLLKVYETVTYSPHPDDSANKTLFQQEAQITAYGSIRKLCNKMEDWSVQRFCENAKKGKMGFDAVLQVFSENWEKHVDDLSNQLVSKVNETMEDVKISAGTLLKGTERSGRTILQQNIDLFRDAYNHEN
SIO_010081: YLR168C
subclass of: SO_0000673
so part of: YLR168C
location: complement(499578..500270)
location: region:499578-500270:-1
so has part: feature:499578-500270:-1:exon

NP_013269.1
type: Protein
SIO_000068: ncbiprotein

S000004158
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499578-500270:-1:exon

YLR170C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YAP19
gene: APS1
locus tag: YLR170C
gene synonym: YAP19
so part of: sequence
location: complement(<500579..>501049)
location: region:500579-501049:-1
so has part: feature:500579-501049:-1:exon
subclass of: SO_0000010

850868
type: Gene
SIO_000068: ncbigene

position:500579:-1
position: 500579
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:501049:-1
position: 501049
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:500579-501049:-1:exon

YLR170C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YAP19
gene: APS1
locus tag: YLR170C
gene synonym: YAP19
product: Aps1p
transcript id: NM_001182057.1
SIO_010081: YLR170C
subclass of: SO_0000673
so part of: YLR170C
location: complement(<500579..>501049)
location: region:500579-501049:-1
so has part: feature:500579-501049:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:500579-501049:-1:exon

YLR170C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YAP19
gene: APS1
locus tag: YLR170C
gene synonym: YAP19
experiment: EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]
note: Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
codon start: 1
product: Aps1p
translation: MTQLKYLLLVSRQGKIRLKKWYTAMSAGEKAKIVKDLTPTILARKPKMCNIIEYNDHKVVYKRYASLYFIVGMTPDVDNELLTLEIIHRFVETMDTYFGNVCELDIIFNFSKVYDILNEMIMCDGSIAESSRKEVLHHVTVMDTMESNDNLERVLS
SIO_010081: YLR170C
subclass of: SO_0000673
so part of: YLR170C
location: complement(500579..501049)
location: region:500579-501049:-1
so has part: feature:500579-501049:-1:exon

NP_013271.1
type: Protein
SIO_000068: ncbiprotein

S000004160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:500579-501049:-1:exon

YLR172C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPH5
locus tag: YLR172C
so part of: sequence
location: complement(<501260..>502162)
location: region:501260-502162:-1
so has part: feature:501260-502162:-1:exon
subclass of: SO_0000010

850869
type: Gene
SIO_000068: ncbigene

position:501260:-1
position: 501260
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502162:-1
position: 502162
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501260-502162:-1:exon

YLR172C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPH5
locus tag: YLR172C
product: diphthine synthase
transcript id: NM_001182059.1
SIO_010081: YLR172C
subclass of: SO_0000673
so part of: YLR172C
location: complement(<501260..>502162)
location: region:501260-502162:-1
so has part: feature:501260-502162:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501260-502162:-1:exon

YLR172C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPH5
locus tag: YLR172C
EC number: 2.1.1.314
experiment: EXISTENCE:direct assay:GO:0004164 diphthine synthase activity [PMID:3042777]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [PMID:3042777]
experiment: EXISTENCE:mutant phenotype:GO:0004164 diphthine synthase activity [PMID:1508200]
experiment: EXISTENCE:mutant phenotype:GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [PMID:1508200]
note: Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
codon start: 1
product: diphthine synthase
translation: MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMAASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAFLVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAVGACGLQLYNFGQTVSMVFFTDNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARGRLIYEPPRYMSIAQCCEQLLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCHELELEYLLEFADDKEKFGKDVANDQEYFKPAAWVPPTEDDSDE
SIO_010081: YLR172C
subclass of: SO_0000673
so part of: YLR172C
location: complement(501260..502162)
location: region:501260-502162:-1
so has part: feature:501260-502162:-1:exon

NP_013273.1
type: Protein
SIO_000068: ncbiprotein

S000004162
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501260-502162:-1:exon

YLR173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TAG1
locus tag: YLR173W
so part of: sequence
location: <502421..>504247
location: region:502421-504247:1
so has part: feature:502421-504247:1:exon
subclass of: SO_0000010

850870
type: Gene
SIO_000068: ncbigene

position:502421:1
position: 502421
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:504247:1
position: 504247
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:502421-504247:1:exon

YLR173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TAG1
locus tag: YLR173W
product: Tag1p
transcript id: NM_001182060.1
SIO_010081: YLR173W
subclass of: SO_0000673
so part of: YLR173W
location: <502421..>504247
location: region:502421-504247:1
so has part: feature:502421-504247:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:502421-504247:1:exon

YLR173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TAG1
locus tag: YLR173W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:26928762|PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:33536246]
note: Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway
codon start: 1
product: Tag1p
translation: MHTNSPLRADNQDLETQPLLRPNTEESQLLNDEVRINVANETLIKSRWRSIKCLIIYLLGIVLLSFFGVSIVQYIRGHVPPTDVIEKNLVQVTNFKLVEFQLDGWKDNMGSDLNNDTGKYLQVSIHSQIWFDYDKWPGTENDSDARSQRDWIRYINEKVLKTICIDLNNVTTFDGDLVFKNKLGDVVGMEPICFNLAHRQINNLQFKILVKPSIWKIVKVLKKFWNRDFESLNIKSNLDMTIFKRKFGTRFNLLKLNDEILDWKDIIDWEKISATPLRMIQNMIDGISLQGFTLRDSSSDGFHADMRLNPITILGGVDWLHLPPGTSIPFINWEIKLPDCNGEPAIAIPTLSCFNEPINLHHDKDNIVVCLQNEIEGPLPDELLYQECPQNSLTPMSQIVNAVLNQNETVTFAARGHVLEDGIDNNSLIPADMLEDIFQEASFIPITTNATFNSSELIQEFQINDLQLRWAARKKLSLVGTFLGFFDLSFYETHQQDRVRIDTIRGQIDLYHNDINFLNLPMKQWINSSSHILHDEDTGNTQMKLQFDLENDDMEVVNSLELTRTLNEILFQGFTVIHFNATIDASLTTALGPWVLTGLAGEGDTLVT
SIO_010081: YLR173W
subclass of: SO_0000673
so part of: YLR173W
location: 502421..504247
location: region:502421-504247:1
so has part: feature:502421-504247:1:exon

NP_013274.1
type: Protein
SIO_000068: ncbiprotein

S000004163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:502421-504247:1:exon

YLR174W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IDP2
locus tag: YLR174W
so part of: sequence
location: <504591..>505829
location: region:504591-505829:1
so has part: feature:504591-505829:1:exon
subclass of: SO_0000010

850871
type: Gene
SIO_000068: ncbigene

position:504591:1
position: 504591
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:505829:1
position: 505829
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504591-505829:1:exon

YLR174W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IDP2
locus tag: YLR174W
product: isocitrate dehydrogenase (NADP(+)) IDP2
transcript id: NM_001182061.1
SIO_010081: YLR174W
subclass of: SO_0000673
so part of: YLR174W
location: <504591..>505829
location: region:504591-505829:1
so has part: feature:504591-505829:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:504591-505829:1:exon

YLR174W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IDP2
locus tag: YLR174W
EC number: 1.1.1.42
experiment: EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:15574419]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15001388|PMID:19854152]
experiment: EXISTENCE:genetic interaction:GO:0006102 isocitrate metabolic process [PMID:15574419]
experiment: EXISTENCE:mutant phenotype:GO:0006102 isocitrate metabolic process [PMID:15574419]
note: Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas
codon start: 1
product: isocitrate dehydrogenase (NADP(+)) IDP2
translation: MTKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSATATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLVPQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYPEHGGVAMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEKFESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQILESATVNTVQEDGIMTKDLALILGKSERSAYVTTEEFIDAVESRLKKEFEAAAL
SIO_010081: YLR174W
subclass of: SO_0000673
so part of: YLR174W
location: 504591..505829
location: region:504591-505829:1
so has part: feature:504591-505829:1:exon

NP_013275.1
type: Protein
SIO_000068: ncbiprotein

S000004164
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:504591-505829:1:exon

YLR175W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CBF5
locus tag: YLR175W
so part of: sequence
location: <506134..>507585
location: region:506134-507585:1
so has part: feature:506134-507585:1:exon
subclass of: SO_0000010

850872
type: Gene
SIO_000068: ncbigene

position:506134:1
position: 506134
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507585:1
position: 507585
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506134-507585:1:exon

YLR175W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CBF5
locus tag: YLR175W
product: pseudouridine synthase CBF5
transcript id: NM_001182062.1
SIO_010081: YLR175W
subclass of: SO_0000673
so part of: YLR175W
location: <506134..>507585
location: region:506134-507585:1
so has part: feature:506134-507585:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506134-507585:1:exon

YLR175W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CBF5
locus tag: YLR175W
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:9472021]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15962000]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:mutant phenotype:GO:0000495 box H/ACA RNA 3'-end processing [PMID:15964797]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9472021]
experiment: EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:9472021]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9472021]
experiment: EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136|PMID:25219674]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9472021]
note: Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs
codon start: 1
product: pseudouridine synthase CBF5
translation: MSKEDFVIKPEAAGASTDTSEWPLLLKNFDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYESNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVMDAQWVYDNTRDESYLRSIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEIVLITTKGEAIAVAIAQMSTVDLASCDHGVVASVKRCIMERDLYPRRWGLGPVAQKKKQMKADGKLDKYGRVNENTPEQWKKEYVPLDNAEQSTSSSQETKETEEEPKKAKEDSLIKEVETEKEEVKEDDSKKEKKEKKDKKEKKEKKEKKDKKEKKEKKEKKRKSEDGDSEEKKSKKSKK
SIO_010081: YLR175W
subclass of: SO_0000673
so part of: YLR175W
location: 506134..507585
location: region:506134-507585:1
so has part: feature:506134-507585:1:exon

NP_013276.1
type: Protein
SIO_000068: ncbiprotein

S000004165
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506134-507585:1:exon

YLR176C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CRT1
gene: RFX1
locus tag: YLR176C
gene synonym: CRT1
so part of: sequence
location: complement(<507797..>510232)
location: region:507797-510232:-1
so has part: feature:507797-510232:-1:exon
subclass of: SO_0000010

850873
type: Gene
SIO_000068: ncbigene

position:507797:-1
position: 507797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:510232:-1
position: 510232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:507797-510232:-1:exon

YLR176C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CRT1
gene: RFX1
locus tag: YLR176C
gene synonym: CRT1
product: Rfx1p
transcript id: NM_001182063.1
SIO_010081: YLR176C
subclass of: SO_0000673
so part of: YLR176C
location: complement(<507797..>510232)
location: region:507797-510232:-1
so has part: feature:507797-510232:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:507797-510232:-1:exon

YLR176C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CRT1
gene: RFX1
locus tag: YLR176C
gene synonym: CRT1
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9741624]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9741624]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16835445]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16835445]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16107689]
note: Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
codon start: 1
product: Rfx1p
translation: MVIFKERKPTENLFTRKIPAKYFIFSPSFLSVHYFEFYLPMSGDNNIEPTSRGSNDNSNGPSNGSSVNSNRYSLNAPKYSSQPPPASHTYLPPMSVNIPPIASKSSSIYSLLHQSSPRPETPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSAYPLSFKSEETLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIAKQIAENNKSKTIEEYAQIVKHAEIKVLSMDSQNTSKAALQLAEQNRERERQVFALLWLMKNCKSQHDSYVPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGLKLTVNESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPVKQSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCNDKLSDNYNTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDVISSLESLYHIHCNSVYECIKFLKSDNISNALFFSNSNSISPTMFNLFISEPLIDWVTKCDLITYTGLIKFFSQFIIHSNEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKLLKFILNFLKSFPIFKSGMNNDWKNIVNLDDILEMMINEDDTNSETNTIMQHLQGFCQVFVTKFLNSSMSVSNDPSVSIECKSLNEMIKDFCSFISLQSKFSCLKLIDCSTRFRNAIIGDISLKSNENLLSWLFLNNVMGQLLNYCFEVMKFVNGLKV
SIO_010081: YLR176C
subclass of: SO_0000673
so part of: YLR176C
location: complement(507797..510232)
location: region:507797-510232:-1
so has part: feature:507797-510232:-1:exon

NP_013277.1
type: Protein
SIO_000068: ncbiprotein

S000004166
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:507797-510232:-1:exon

YLR177W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR177W
so part of: sequence
location: <511054..>512940
location: region:511054-512940:1
so has part: feature:511054-512940:1:exon
subclass of: SO_0000010

850874
type: Gene
SIO_000068: ncbigene

position:511054:1
position: 511054
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:512940:1
position: 512940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:511054-512940:1:exon

YLR177W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR177W
product: uncharacterized protein
transcript id: NM_001182064.1
SIO_010081: YLR177W
subclass of: SO_0000673
so part of: YLR177W
location: <511054..>512940
location: region:511054-512940:1
so has part: feature:511054-512940:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:511054-512940:1:exon

YLR177W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR177W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MELPSINSTTSISDNQELRNYYDKLLFKNNSGKSLADLPGKMADFNDNSAAAHPRSRVDFINGYIGFREDKQSLLGQKNTKRASFSAFADEGRKQSEMSINGKSPNLSLFSFEFNGTPTQDRKPYKQDYLNVMNTSPNNILSPLNNSSQKYYPQKQQQQQQQQQQQQQQSIFDPGRRSSYISDALIHGNAATQQPQYSQPVYINNNPSLQVPYTAPSEYTQQQQYSSPFNARRNTQPVLNLHPAAAPTNDAGLAVVDGKNLTSSKELHDLYLDCGSNYFASDKVYKFIDSIKGTLRGDNVSASSSRIIEFLDFLKNCNLNYNPQSDAFISTAVSNASSTGAAKSKNSTSMHLHYKPLVLVSLKNGKLELLSKPQTATLILKRGDLVIIDGDRGKDLVLVVEPVVDINLALFINFLKKKIHFDSLITNSQQHFPNDQFIKTLVDTTNGKPVAHELNPKLYDIIELTQLIIPSKQVLRFATPWESSTNLHNKFQDELKALHIAQLKLRSLNNNNSGGGLNIKILNAEFQFDRKKLTFYYICQERNDFRDLIKELFKFYKTRIWLCAIPNNLSIDSKFYDSNKFEWEMYQDMMSHYSMDNTGIVVAPELNRLKLDDFQIGVYMELVKVLFG
SIO_010081: YLR177W
subclass of: SO_0000673
so part of: YLR177W
location: 511054..512940
location: region:511054-512940:1
so has part: feature:511054-512940:1:exon

NP_013278.1
type: Protein
SIO_000068: ncbiprotein

S000004167
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:511054-512940:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1217; Autonomously Replicating Sequence
so part of: sequence
location: 512867..513115
location: region:512867-513115:1
so has part: feature:512867-513115:1:region

S000118476
type: SGD
SIO_000068: sgd

position:512867:1
position: 512867
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:513115:1
position: 513115
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:512867-513115:1:region

YLR178C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DKA1
alternative label: NSP1
gene: TFS1
locus tag: YLR178C
gene synonym: DKA1; NSP1
so part of: sequence
location: complement(<513162..>513821)
location: region:513162-513821:-1
so has part: feature:513162-513821:-1:exon
subclass of: SO_0000010

850875
type: Gene
SIO_000068: ncbigene

position:513162:-1
position: 513162
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:513821:-1
position: 513821
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513162-513821:-1:exon

YLR178C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DKA1
alternative label: NSP1
gene: TFS1
locus tag: YLR178C
gene synonym: DKA1; NSP1
product: Tfs1p
transcript id: NM_001182065.1
SIO_010081: YLR178C
subclass of: SO_0000673
so part of: YLR178C
location: complement(<513162..>513821)
location: region:513162-513821:-1
so has part: feature:513162-513821:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:513162-513821:-1:exon

YLR178C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DKA1
alternative label: NSP1
gene: TFS1
locus tag: YLR178C
gene synonym: DKA1; NSP1
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:17317927]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17317927]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17076703]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17317927]
experiment: EXISTENCE:direct assay:GO:0030162 regulation of proteolysis [PMID:9521655]
experiment: EXISTENCE:direct assay:GO:0030414 peptidase inhibitor activity [PMID:9521655]
experiment: EXISTENCE:mutant phenotype:GO:0046578 regulation of Ras protein signal transduction [PMID:15075275]
experiment: EXISTENCE:physical interaction:GO:0046578 regulation of Ras protein signal transduction [PMID:15075275]
note: Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
codon start: 1
product: Tfs1p
translation: MNQAIDFAQASIDSYKKHGILEDVIHDTSFQPSGILAVEYSSSAPVAMGNTLPTEKARSKPQFQFTFNKQMQKSVPQANAYVPQDDDLFTLVMTDPDAPSKTDHKWSEFCHLVECDLKLLNEATHETSGATEFFASEFNTKGSNTLIEYMGPAPPKGSGPHRYVFLLYKQPKGVDSSKFSKIKDRPNWGYGTPATGVGKWAKENNLQLVASNFFYAETK
SIO_010081: YLR178C
subclass of: SO_0000673
so part of: YLR178C
location: complement(513162..513821)
location: region:513162-513821:-1
so has part: feature:513162-513821:-1:exon

NP_013279.1
type: Protein
SIO_000068: ncbiprotein

S000004168
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:513162-513821:-1:exon

YLR179C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR179C
so part of: sequence
location: complement(<514108..>514713)
location: region:514108-514713:-1
so has part: feature:514108-514713:-1:exon
subclass of: SO_0000010

850876
type: Gene
SIO_000068: ncbigene

position:514108:-1
position: 514108
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:514713:-1
position: 514713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:514108-514713:-1:exon

YLR179C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR179C
product: uncharacterized protein
transcript id: NM_001182066.1
SIO_010081: YLR179C
subclass of: SO_0000673
so part of: YLR179C
location: complement(<514108..>514713)
location: region:514108-514713:-1
so has part: feature:514108-514713:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:514108-514713:-1:exon

YLR179C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR179C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17317927|PMID:14562095|PMID:11914276]
note: hypothetical protein with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
codon start: 1
product: uncharacterized protein
translation: MSSAIVAKLNKEDIIKDTVKDLAFEILGELSVSYVDSDDIKLGNPMPMEATQAAPTIKFTPFDKSQLSAEDKLALLMTDPDAPSRTEHKWSEVCHYIITDIPVEYGPGGDIAISGKGVVRNNYIGPGPPKNSGYHRYVFFLCKQPKGADSSTFTKVENIISWGYGTPGAGAYDYIKENNLQLVGANYYMVENTTVDFNYDM
SIO_010081: YLR179C
subclass of: SO_0000673
so part of: YLR179C
location: complement(514108..514713)
location: region:514108-514713:-1
so has part: feature:514108-514713:-1:exon

NP_013280.1
type: Protein
SIO_000068: ncbiprotein

S000004169
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:514108-514713:-1:exon

YLR180W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ETH10
gene: SAM1
locus tag: YLR180W
gene synonym: ETH10
so part of: sequence
location: <515262..>516410
location: region:515262-516410:1
so has part: feature:515262-516410:1:exon
subclass of: SO_0000010

850877
type: Gene
SIO_000068: ncbigene

position:515262:1
position: 515262
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516410:1
position: 516410
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:515262-516410:1:exon

YLR180W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ETH10
gene: SAM1
locus tag: YLR180W
gene synonym: ETH10
product: methionine adenosyltransferase SAM1
transcript id: NM_001182067.1
SIO_010081: YLR180W
subclass of: SO_0000673
so part of: YLR180W
location: <515262..>516410
location: region:515262-516410:1
so has part: feature:515262-516410:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:515262-516410:1:exon

YLR180W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ETH10
gene: SAM1
locus tag: YLR180W
gene synonym: ETH10
EC number: 2.5.1.6
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:genetic interaction:GO:0004478 methionine adenosyltransferase activity [PMID:3316224]
experiment: EXISTENCE:mutant phenotype:GO:0006555 methionine metabolic process [PMID:4580557]
experiment: EXISTENCE:mutant phenotype:GO:0006556 S-adenosylmethionine biosynthetic process [PMID:17426150]
experiment: EXISTENCE:mutant phenotype:GO:0062030 negative regulation of stress granule assembly [PMID:32609300]
note: S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
codon start: 1
product: methionine adenosyltransferase SAM1
translation: MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF
SIO_010081: YLR180W
subclass of: SO_0000673
so part of: YLR180W
location: 515262..516410
location: region:515262-516410:1
so has part: feature:515262-516410:1:exon

NP_013281.1
type: Protein
SIO_000068: ncbiprotein

S000004170
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:515262-516410:1:exon

YLR181C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VTA1
locus tag: YLR181C
so part of: sequence
location: complement(<516678..>517670)
location: region:516678-517670:-1
so has part: feature:516678-517670:-1:exon
subclass of: SO_0000010

850878
type: Gene
SIO_000068: ncbigene

position:516678:-1
position: 516678
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:517670:-1
position: 517670
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:516678-517670:-1:exon

YLR181C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VTA1
locus tag: YLR181C
product: Vta1p
transcript id: NM_001182068.1
SIO_010081: YLR181C
subclass of: SO_0000673
so part of: YLR181C
location: complement(<516678..>517670)
location: region:516678-517670:-1
so has part: feature:516678-517670:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:516678-517670:-1:exon

YLR181C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VTA1
locus tag: YLR181C
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16505166|PMID:16601096]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005771 multivesicular body [PMID:14701806]
experiment: EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:16505166]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:16505166]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:16505166]
experiment: EXISTENCE:mutant phenotype:GO:0001671 ATPase activator activity [PMID:16505166]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12953057]
note: Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain
codon start: 1
product: Vta1p
translation: MASNAARVVATAKDFDKVGLGIIGYYLQLYAVELILSEEDRSQEMTALATELLDTIEAFKKEIGGESEAEDSDKSLHVMNTLIHDQEKAKIYMLNFTMSLYNEKLKQLKDGPWDVMLKRSLWCCIDLFSCILHLWKENISETSTNSLQKRIKYCKIYLSKLAKGEIGSSDEKTLDYADFADDSEEIKDEDVDHQTSDLENNNNDKVEGLAPKDQTTSYEPVDEVPEFIDDADSVNEEEQTVDKNEDAITKDEQQVVKKEVDLTRPSAPSEPAAAEHKSYTKDELTKIMDRASKIEQIQKLAKYAISALNYEDLPTAKDELTKALDLLNSI
SIO_010081: YLR181C
subclass of: SO_0000673
so part of: YLR181C
location: complement(516678..517670)
location: region:516678-517670:-1
so has part: feature:516678-517670:-1:exon

NP_013282.1
type: Protein
SIO_000068: ncbiprotein

S000004171
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:516678-517670:-1:exon

YLR182W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSL8
alternative label: SDS11
gene: SWI6
locus tag: YLR182W
gene synonym: PSL8; SDS11
so part of: sequence
location: <517940..>520351
location: region:517940-520351:1
so has part: feature:517940-520351:1:exon
subclass of: SO_0000010

850879
type: Gene
SIO_000068: ncbigene

position:517940:1
position: 517940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520351:1
position: 520351
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517940-520351:1:exon

YLR182W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSL8
alternative label: SDS11
gene: SWI6
locus tag: YLR182W
gene synonym: PSL8; SDS11
product: transcriptional regulator SWI6
transcript id: NM_001182069.1
SIO_010081: YLR182W
subclass of: SO_0000673
so part of: YLR182W
location: <517940..>520351
location: region:517940-520351:1
so has part: feature:517940-520351:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517940-520351:1:exon

YLR182W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSL8
alternative label: SDS11
gene: SWI6
locus tag: YLR182W
gene synonym: PSL8; SDS11
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9719633]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12697814|PMID:8590795|PMID:24470217]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12697814|PMID:8590795]
experiment: EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:8372350]
experiment: EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:1832338|PMID:8423776]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9719633]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:9719633]
experiment: EXISTENCE:mutant phenotype:GO:0010845 positive regulation of reciprocal meiotic recombination [PMID:9628912]
experiment: EXISTENCE:mutant phenotype:GO:0033309 SBF transcription complex [PMID:8423776]
experiment: EXISTENCE:mutant phenotype:GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress [PMID:20641022]
experiment: EXISTENCE:mutant phenotype:GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:2649246|PMID:3542227]
experiment: EXISTENCE:physical interaction:GO:0033309 SBF transcription complex [PMID:1465410]
note: Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators
codon start: 1
product: transcriptional regulator SWI6
translation: MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEERNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSHSKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTPNTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPVVNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVNDAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVKSVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIVKKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARLGNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNGKAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELANSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSEYDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPTVLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQAISSEDPQDIDTDEMQDFLKKHAS
SIO_010081: YLR182W
subclass of: SO_0000673
so part of: YLR182W
location: 517940..520351
location: region:517940-520351:1
so has part: feature:517940-520351:1:exon

NP_013283.1
type: Protein
SIO_000068: ncbiprotein

S000004172
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517940-520351:1:exon

YLR183C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOS4
locus tag: YLR183C
so part of: sequence
location: complement(<520543..>522012)
location: region:520543-522012:-1
so has part: feature:520543-522012:-1:exon
subclass of: SO_0000010

850880
type: Gene
SIO_000068: ncbigene

position:520543:-1
position: 520543
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522012:-1
position: 522012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520543-522012:-1:exon

YLR183C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOS4
locus tag: YLR183C
product: Tos4p
transcript id: NM_001182070.1
SIO_010081: YLR183C
subclass of: SO_0000673
so part of: YLR183C
location: complement(<520543..>522012)
location: region:520543-522012:-1
so has part: feature:520543-522012:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:520543-522012:-1:exon

YLR183C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOS4
locus tag: YLR183C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12464632]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:12760057|PMID:22333912]
experiment: EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]
note: Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress
codon start: 1
product: Tos4p
translation: MSSQFPSSPYRTVDPYSPPNYKQQPNCPSSNYEKAGKTASESIGNFGKGDYPTPFPSSSIGRVSSPVRSNKVDAIPSSPAFPGQLAETSPKFSSKLSSPSRHTRVINAELDPSKISTITVGRNSSQCDVALCKNKFISRVHASITYLPQTNEVKIHCFSMNGLIVTYRKQFDCYQLKDTMNNNNRAYRLVPRFSNEKCVKEIQDEGGFINFTLEEGDTVYMTYYKGIMLDFRQVLLRISLKEKNSSSEPLRFEKKAEFESESETKHMGSIRKHPLIFTDTSMDRPKKILKDSNKISIGSDSGVAERMLNHFLNSKSSPLSSVSSVDHEEQTLRQDSLSSDKNPMTMKKPKLNKRVLPSKPKKSVKENLDELSRRNIDVMHLQHILTNHLAFANVQQTPLFQLQQVNSQISELSRDELRSILSDAKCVGVIYRHGKDAAGKPLDEEYFYDLENDDDYERRNLVSSLKGGRTGLRSCRRTHKQYFWKKPAK
SIO_010081: YLR183C
subclass of: SO_0000673
so part of: YLR183C
location: complement(520543..522012)
location: region:520543-522012:-1
so has part: feature:520543-522012:-1:exon

NP_013284.1
type: Protein
SIO_000068: ncbiprotein

S000004173
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520543-522012:-1:exon

YLR185W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL37A
locus tag: YLR185W
so part of: sequence
location: <522663..>523288
location: region:522663-523288:1
so has part: feature:522663-523288:1:exon
subclass of: SO_0000010

850882
type: Gene
SIO_000068: ncbigene

position:522663:1
position: 522663
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:523288:1
position: 523288
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:522663-523288:1:exon

YLR185W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL37A
locus tag: YLR185W
product: ribosomal 60S subunit protein L37A
transcript id: NM_001182072.1
SIO_010081: YLR185W
subclass of: SO_0000673
so part of: YLR185W
location: join(<522663..522669,523029..>523288)
location: region:522663-523288:1
so has part: feature:522663-522669:1:exon
so has part: feature:523029-523288:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:522663-522669:1:exon

position:522669:1
position: 522669
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:523029-523288:1:exon

position:523029:1
position: 523029
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR185W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL37A
locus tag: YLR185W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]
experiment: EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]
note: Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L37A
translation: MGKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKTRSYNWGAKAKRRHTTGTGRMRYLKHVSRRFKNGFQTGSASKASA
SIO_010081: YLR185W
subclass of: SO_0000673
so part of: YLR185W
location: join(522663..522669,523029..523288)
location: region:522663-523288:1
so has part: feature:522663-522669:1:exon
so has part: feature:523029-523288:1:exon

NP_013286.1
type: Protein
SIO_000068: ncbiprotein

S000004175
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:522663-522669:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:523029-523288:1:exon

YLR186W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NEP1
gene: EMG1
locus tag: YLR186W
gene synonym: NEP1
so part of: sequence
location: <523632..>524390
location: region:523632-524390:1
so has part: feature:523632-524390:1:exon
subclass of: SO_0000010

850883
type: Gene
SIO_000068: ncbigene

position:523632:1
position: 523632
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524390:1
position: 524390
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523632-524390:1:exon

YLR186W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NEP1
gene: EMG1
locus tag: YLR186W
gene synonym: NEP1
product: 18S rRNA pseudouridine methyltransferase
transcript id: NM_001182073.1
SIO_010081: YLR186W
subclass of: SO_0000673
so part of: YLR186W
location: <523632..>524390
location: region:523632-524390:1
so has part: feature:523632-524390:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523632-524390:1:exon

YLR186W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NEP1
gene: EMG1
locus tag: YLR186W
gene synonym: NEP1
EC number: 2.1.1.260
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11694595|PMID:11935223]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11694595|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:11935223]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22588997|PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16721597]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11694595]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:11694595]
experiment: EXISTENCE:mutant phenotype:GO:0070037 rRNA (pseudouridine) methyltransferase activity [PMID:20972225]
experiment: EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:20972225]
note: Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant
codon start: 1
product: 18S rRNA pseudouridine methyltransferase
translation: MVEDSRVRDALKGGDQKALPASLVPQAPPVLTSKDKITKRMIVVLAMASLETHKISSNGPGGDKYVLLNCDDHQGLLKKMGRDISEARPDITHQCLLTLLDSPINKAGKLQVYIQTSRGILIEVNPTVRIPRTFKRFSGLMVQLLHKLSIRSVNSEEKLLKVIKNPITDHLPTKCRKVTLSFDAPVIRVQDYIEKLDDDESICVFVGAMARGKDNFADEYVDEKVGLSNYPLSASVACSKFCHGAEDAWNIL
SIO_010081: YLR186W
subclass of: SO_0000673
so part of: YLR186W
location: 523632..524390
location: region:523632-524390:1
so has part: feature:523632-524390:1:exon

NP_013287.1
type: Protein
SIO_000068: ncbiprotein

S000004176
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523632-524390:1:exon

YLR187W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKG3
locus tag: YLR187W
so part of: sequence
location: <524865..>527945
location: region:524865-527945:1
so has part: feature:524865-527945:1:exon
subclass of: SO_0000010

850884
type: Gene
SIO_000068: ncbigene

position:524865:1
position: 524865
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:527945:1
position: 527945
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:524865-527945:1:exon

YLR187W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKG3
locus tag: YLR187W
product: Skg3p
transcript id: NM_001182074.1
SIO_010081: YLR187W
subclass of: SO_0000673
so part of: YLR187W
location: <524865..>527945
location: region:524865-527945:1
so has part: feature:524865-527945:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:524865-527945:1:exon

YLR187W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKG3
locus tag: YLR187W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095|PMID:22842922]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
codon start: 1
product: Skg3p
translation: MKRIFSGVKSPKLSAPPKVFKNDESPSTPSSPKFDQGLRSLSASASRLFSNSISTPGSPTLDLPQEHSINGDISPELVPIVTLLSAQAHRRYHYGIFLILHDLKTDGTPAARQWEECYGVLLGTQLALWDAKELSDSKNNKNTSTMKKAASRPSFINFTDASVRSLDANDQVIIASENEKTKKDLDNVLVVSTTLKNRYFLKFKNSKSFKTWNAAIRLSLFEFTALQEAYTGSFLSSRGVKLGDIKVVMADTKFTYEDWVSVRFGTGMPWKRCYAVISPQSGKKKKNSKGSICFYENNKKTKKSNIMTTVVDARALYAVYPSSPILIDTSTIIKLEGFVSFDKSEEPQETNLFIMPEKHQGVPGYDTIIRFLIPAMNAFYLYGRPKGLIANRTDPDSLLFALPTLPHIYYLQVDDVLSLTKDKNYIHWSAADWRNNIVQVLQKKLSKGYKGCGNKTVSVSSGMMKSPAISSAELFEGYDSLPERQMESPQKSKMKSPTLASTDDINSASASVNSHATSVKQTELFVTDNSSKINDSVSAQSSVTTNFKDTFTTPMTSGMLNHENSERSFGSGLKLKITDSNLENMEDVEAKSANEFSTTPEDKHIHLANAAELSALYDKYSTSPFGKSEANSSPKPQKLEVKDRSKNENRSPYERYVGTSAESKTFEIGNVRESKSTINTSLSSPLRVEDSRRSKNEDLGSLKEFEELSQKISNMGMANISSEALSDTAENSSFVTDLNLNINNSSSVNLNEEQRVPDFGEENVFDPDYMEQNQMLETESRYTTDEFDFSDNQDAASSNYSNGQTNRTVTETLSASDRNDKIPHSSLFTNLNQLTSNGGNYQDREDFSGDQINKPQQSQPLHVKGPQTSSFGYRNSSANSSQPQAPYPVGRPLGKIRTGPLTVQPMQQGGNSSMYSFQSSQHRFHSSQQRQNQSLSFRNNTYGSGNNQNTFHPSPQLQQQPQNMRYLNNKLPINDRSPIPQTQHHVPDGRPSLHINTTNRTNPLTAQSGFSQFMPPNSTSTNPYSS
SIO_010081: YLR187W
subclass of: SO_0000673
so part of: YLR187W
location: 524865..527945
location: region:524865-527945:1
so has part: feature:524865-527945:1:exon

NP_013288.1
type: Protein
SIO_000068: ncbiprotein

S000004177
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:524865-527945:1:exon

YLR188W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDL1
locus tag: YLR188W
so part of: sequence
location: <528300..>530387
location: region:528300-530387:1
so has part: feature:528300-530387:1:exon
subclass of: SO_0000010

850885
type: Gene
SIO_000068: ncbigene

position:528300:1
position: 528300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:530387:1
position: 530387
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:528300-530387:1:exon

YLR188W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDL1
locus tag: YLR188W
product: ATP-binding cassette permease MDL1
transcript id: NM_001182075.1
SIO_010081: YLR188W
subclass of: SO_0000673
so part of: YLR188W
location: <528300..>530387
location: region:528300-530387:1
so has part: feature:528300-530387:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:528300-530387:1:exon

YLR188W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDL1
locus tag: YLR188W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11251115]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12746444]
experiment: EXISTENCE:mutant phenotype:GO:0015421 ABC-type oligopeptide transporter activity [PMID:11251115]
experiment: EXISTENCE:mutant phenotype:GO:0090374 oligopeptide export from mitochondrion [PMID:11251115]
note: Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress
codon start: 1
product: ATP-binding cassette permease MDL1
translation: MIVRMIRLCKGPKLLRSQFASASALYSTKSLFKPPMYQKAEINLIIPHRKHFLLRSIRLQSDIAQGKKSTKPTLKLSNANSKSSGFKDIKRLFVLSKPESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEEGSKSNKLYGFTKKQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFLDTNRVGDLISRLSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFLSWKLTCVMMILAPPLGAMALIYGRKIRNLSRQLQTSVGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIGLKEAVTSGLFFGSTGLVGNTAMLSLLLVGTSMIQSGSMTVGELSSFMMYAVYTGSSLFGLSSFYSELMKGAGAAARVFELNDRKPLIRPTIGKDPVSLAQKPIVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAVGPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNILYCIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAVLILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRDLIAIPNSELNALLAEQQDEEGKGGVIDLDNSVAREV
SIO_010081: YLR188W
subclass of: SO_0000673
so part of: YLR188W
location: 528300..530387
location: region:528300-530387:1
so has part: feature:528300-530387:1:exon

NP_013289.1
type: Protein
SIO_000068: ncbiprotein

S000004178
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:528300-530387:1:exon

YLR189C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UGT51
gene: ATG26
locus tag: YLR189C
gene synonym: UGT51
so part of: sequence
location: complement(<530797..>534393)
location: region:530797-534393:-1
so has part: feature:530797-534393:-1:exon
subclass of: SO_0000010

850886
type: Gene
SIO_000068: ncbigene

position:530797:-1
position: 530797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:534393:-1
position: 534393
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:530797-534393:-1:exon

YLR189C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UGT51
gene: ATG26
locus tag: YLR189C
gene synonym: UGT51
product: sterol 3-beta-glucosyltransferase
transcript id: NM_001182076.1
SIO_010081: YLR189C
subclass of: SO_0000673
so part of: YLR189C
location: complement(<530797..>534393)
location: region:530797-534393:-1
so has part: feature:530797-534393:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:530797-534393:-1:exon

YLR189C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UGT51
gene: ATG26
locus tag: YLR189C
gene synonym: UGT51
EC number: 2.4.1.173
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016906 sterol 3-beta-glucosyltransferase activity [PMID:10224056]
experiment: EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:18756268]
experiment: EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:10224056]
note: UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
codon start: 1
product: sterol 3-beta-glucosyltransferase
translation: MPITQIISASDSEAGPKPSISLVPDKPSEPETSPRHHRLSRSLSKFKRWRGRSNSSLSMGSSEQQELQDSPNEARSDDDENGYNNDNADDLAKSKYMMKSIAGLLTTASVYAGMNNAQEMNVLSQVDSEESDSSDSFQENIGRNEVKSKKENLKTKSHPEVPRLDKRKPTLFDFSITREKLSKDNVAKLRQRFCLDEQEPFLNDFPAWLLKDVLVQGHIFITTKHFLFFAYLPKNPRSVKMSGNLNIRTKLIRSTRYWCVLKNHLFSMYTSSTELYFPVLTIDLREVQKIETQKHTLNGSATKTFKLYTDESTFKFNADSEFSAKSWVNALKKEQFAAQNSENNSISLKIPLPNIIEIDDQPIVNKALTLRLRALESSQTYAIDDFMFVFMDGSGSQVKESLGEQLAILQKSGVNTLYYDIPAKKSKSSFGKETPATVEQKNNGEDSKYLNVPTSAVPSSENGKKSRFRFRERSNSWFRRAKPLEDSQVEDVEEIYKDAANDIDSSVHSTIHIHEQEDSQEQTVAWKPSHLKNFAEMWAAKPIHYRNKFIPFQKDDTYLIKETEEVSANERFRYHFKFNKEKSLISTYYTYLNRNVPVYGKIYVSNDTVCFRSLLPGSNTYMVLPLVDVETCYKEKGFRFGYFVLVIVIHGHEELFFEFSTEVARDDIERILLKLLDNIYASSAEGSNISSASLGDVQHNPDSAKLKLFEDKINAEGFEVPLMIDENPHYKTSIKPNKSYKFGLLTIGSRGDVQPYIALGKGLIKEGHQVVIITHSEFRDFVESHGIQFEEIAGNPVELMSLMVENESMNVKMLREASSKFRGWIDALLQTSWEVCNRRKFDILIESPSAMVGIHITEALQIPYFRAFTMPWTRTRAYPHAFIVPDQKRGGNYNYLTHVLFENVFWKGISGQVNKWRVETLGLGKTNLFLLQQNNVPFLYNVSPTIFPPSIDFSEWVRVTGYWFLDDKSTFKPPAELQEFISEARSKGKKLVYIGFGSIVVSNAKEMTEALVEAVMEADVYCILNKGWSERLGDKAAKKTEVDLPRNILNIGNVPHDWLFPQVDAAVHHGGSGTTGASLRAGLPTVIKPFFGDQFFYAGRVEDIGVGIALKKLNAQTLADALKVATTNKIMKDRAGLIKKKISKEDGIKTAISAIYNELEYARSVTLSRVKTPRKKEENVDATKLTPAETTDEGWTMI
SIO_010081: YLR189C
subclass of: SO_0000673
so part of: YLR189C
location: complement(530797..534393)
location: region:530797-534393:-1
so has part: feature:530797-534393:-1:exon

NP_013290.1
type: Protein
SIO_000068: ncbiprotein

S000004179
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:530797-534393:-1:exon

YLR190W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MMR1
locus tag: YLR190W
so part of: sequence
location: <535214..>536689
location: region:535214-536689:1
so has part: feature:535214-536689:1:exon
subclass of: SO_0000010

850887
type: Gene
SIO_000068: ncbigene

position:535214:1
position: 535214
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:536689:1
position: 536689
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535214-536689:1:exon

YLR190W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MMR1
locus tag: YLR190W
product: Mmr1p
transcript id: NM_001182077.1
SIO_010081: YLR190W
subclass of: SO_0000673
so part of: YLR190W
location: <535214..>536689
location: region:535214-536689:1
so has part: feature:535214-536689:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:535214-536689:1:exon

YLR190W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MMR1
locus tag: YLR190W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:30044712]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15201867|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:13679573]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22119524]
experiment: EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340]
experiment: EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:15201867]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:15201867|PMID:18245340]
experiment: EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:35281729|PMID:15201867|PMID:22119524]
note: Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins
codon start: 1
product: Mmr1p
translation: MNSPTMKSEQLTPKLSPMSFCLDDQRNAGSFQNLLNSPTKLKLDTGPIGNSLLYPTSLSKLSELSRGGRSKQRRGSDTMRSVSPIRFQFLNNTPKMLKPEYLSQTTSNLPLLSALLKNSKKTTSEGQNSNPDPLNIEKNIIKQSIKDKLEQLRSSESVAQVQKKERNPPSFEAKVCAEEPILRKNAEGLLPSYVPVPATPLEDPENHGVRKVEDKGLRVVSGGSTQCLSTEVNELPKDLNLDNLPTDNNGFVQYGLKGNNNNNRYSFISSTSTDYEPEWCDGQQHISMQMASMANAEEANSREKSNLDIKIKQLELEITELKLQNEKLVHSMTTNRYIEERFMLEVMKDPSIQAQRSQRDIERKVKQLEKKFFNCKKVLKKLTESSAVVATSTSKTEGNSARIPCPKTRLARVSVLDLKKIEEQPDSSSGTSSEEDHLTNDDTDANTSEDLNVAFEEEPTSAISTTASVQSGESKRGFQLNLPVQVEKKEK
SIO_010081: YLR190W
subclass of: SO_0000673
so part of: YLR190W
location: 535214..536689
location: region:535214-536689:1
so has part: feature:535214-536689:1:exon

NP_013291.1
type: Protein
SIO_000068: ncbiprotein

S000004180
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:535214-536689:1:exon

YLR191W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS20
gene: PEX13
locus tag: YLR191W
gene synonym: PAS20
so part of: sequence
location: <537272..>538432
location: region:537272-538432:1
so has part: feature:537272-538432:1:exon
subclass of: SO_0000010

850888
type: Gene
SIO_000068: ncbigene

position:537272:1
position: 537272
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538432:1
position: 538432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:537272-538432:1:exon

YLR191W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS20
gene: PEX13
locus tag: YLR191W
gene synonym: PAS20
product: peroxin PEX13
transcript id: NM_001182078.1
SIO_010081: YLR191W
subclass of: SO_0000673
so part of: YLR191W
location: <537272..>538432
location: region:537272-538432:1
so has part: feature:537272-538432:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:537272-538432:1:exon

YLR191W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS20
gene: PEX13
locus tag: YLR191W
gene synonym: PAS20
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:8858167|PMID:8858166]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:12667447|PMID:22375831]
experiment: EXISTENCE:genetic interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:10087260]
experiment: EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:10087260|PMID:12595255|PMID:15798189]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10087260|PMID:12595255]
note: Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant
codon start: 1
product: peroxin PEX13
translation: MSSTAVPRPKPWETSASLEEPQRNAQSLSAMMTSNQQDSRPTEESNNSNSASESAPEVLPRPAALNSSGTYGESNTIPGIYGNSNYGIPYDNNPYSMNSIYGNSIGRYGYGGSYYGNNYGSFYGGGYGAGAGYGMNNGSGLGESTKATFQLIESLIGAVTGFAQMLESTYMATHNSFFTMISVAEQFGNLKEMLGSFFGIFAIMKFLKKILYRATKGRLGIPPKNFAESEGSKNKLIEDFQKFNDSGTINSNEKATRRKISWKPLLFFLMAVFGFPYLLNKFITKLQTSGTIRASQGNGSEPIDPSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRTKNGNIGYIPYNYIEIIKRRKKIEHVDDETRTH
SIO_010081: YLR191W
subclass of: SO_0000673
so part of: YLR191W
location: 537272..538432
location: region:537272-538432:1
so has part: feature:537272-538432:1:exon

NP_013292.1
type: Protein
SIO_000068: ncbiprotein

S000004181
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:537272-538432:1:exon

YLR192C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HCR1
locus tag: YLR192C
so part of: sequence
location: complement(<538792..>539589)
location: region:538792-539589:-1
so has part: feature:538792-539589:-1:exon
subclass of: SO_0000010

850889
type: Gene
SIO_000068: ncbigene

position:538792:-1
position: 538792
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:539589:-1
position: 539589
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538792-539589:-1:exon

YLR192C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HCR1
locus tag: YLR192C
product: translation initiation factor eIF3 core subunit j
transcript id: NM_001182079.1
SIO_010081: YLR192C
subclass of: SO_0000673
so part of: YLR192C
location: complement(<538792..>539589)
location: region:538792-539589:-1
so has part: feature:538792-539589:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538792-539589:-1:exon

YLR192C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HCR1
locus tag: YLR192C
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11560931]
experiment: EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:11179233]
experiment: EXISTENCE:physical interaction:GO:0003743 translation initiation factor activity [PMID:11179233]
experiment: EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:11179233]
note: eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for 20S pre-rRNA processing; required at post-transcriptional step for efficient retrotransposition; absence decreases Ty1 Gag:GFP protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 also involved in programmed stop codon read through; human homolog EIF3J can complement yeast hcr1 mutant
codon start: 1
product: translation initiation factor eIF3 core subunit j
translation: MSWDDEAINGSMGNDDAVLMDSWDAEIGDDEPVMQSWDAEEEEKKPAPKPKKEQPKKVKKGKESSADRALLDIDTLDEKTRKELIKKAEMESDLNNAADLFAGLGVAEEHPRARALQKEQEEQALKRPAFTKDTPIETHPLFNAETKREYQDLRKALTAAITPMNKKSPLNYSSSLAIDLIRDVAKPMSIESIRQTVATLNVLIKDKEREERQARLARVRGGTATGGAGKKKVKGKTNLGGAFKKDQDFDLDGPDDFEFGDDDFM
SIO_010081: YLR192C
subclass of: SO_0000673
so part of: YLR192C
location: complement(538792..539589)
location: region:538792-539589:-1
so has part: feature:538792-539589:-1:exon

NP_013293.1
type: Protein
SIO_000068: ncbiprotein

S000004182
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538792-539589:-1:exon

YLR193C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UPS1
locus tag: YLR193C
so part of: sequence
location: complement(<540009..>540536)
location: region:540009-540536:-1
so has part: feature:540009-540536:-1:exon
subclass of: SO_0000010

850890
type: Gene
SIO_000068: ncbigene

position:540009:-1
position: 540009
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540536:-1
position: 540536
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540009-540536:-1:exon

YLR193C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UPS1
locus tag: YLR193C
product: Ups1p
transcript id: NM_001182080.1
SIO_010081: YLR193C
subclass of: SO_0000673
so part of: YLR193C
location: complement(<540009..>540536)
location: region:540009-540536:-1
so has part: feature:540009-540536:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540009-540536:-1:exon

YLR193C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UPS1
locus tag: YLR193C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:26235513]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:16754953|PMID:19506038]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:23042293]
experiment: EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:26235513]
experiment: EXISTENCE:direct assay:GO:1990050 phosphatidic acid transfer activity [PMID:23042293]
experiment: EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:23042293]
experiment: EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:19221197|PMID:19506038]
experiment: EXISTENCE:mutant phenotype:GO:1990050 phosphatidic acid transfer activity [PMID:23042293]
experiment: EXISTENCE:mutant phenotype:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:22403410]
note: Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
codon start: 1
product: Ups1p
translation: MVLLHKSTHIFPTDFASVSRAFFNRYPNPYSPHVLSIDTISRNVDQEGNLRTTRLLKKSGKLPTWVKPFLRGITETWIIEVSVVNPANSTMKTYTRNLDHTGIMKVEEYTTYQFDSATSSTIADSRVKFSSGFNMGIKSKVEDWSRTKFDENVKKSRMGMAFVIQKLEEARNPQF
SIO_010081: YLR193C
subclass of: SO_0000673
so part of: YLR193C
location: complement(540009..540536)
location: region:540009-540536:-1
so has part: feature:540009-540536:-1:exon

NP_013294.1
type: Protein
SIO_000068: ncbiprotein

S000004183
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540009-540536:-1:exon

YLR194C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NCW2
locus tag: YLR194C
so part of: sequence
location: complement(<540809..>541573)
location: region:540809-541573:-1
so has part: feature:540809-541573:-1:exon
subclass of: SO_0000010

850891
type: Gene
SIO_000068: ncbigene

position:540809:-1
position: 540809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:541573:-1
position: 541573
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540809-541573:-1:exon

YLR194C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NCW2
locus tag: YLR194C
product: Ncw2p
transcript id: NM_001182081.1
SIO_010081: YLR194C
subclass of: SO_0000673
so part of: YLR194C
location: complement(<540809..>541573)
location: region:540809-541573:-1
so has part: feature:540809-541573:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540809-541573:-1:exon

YLR194C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NCW2
locus tag: YLR194C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:11016834]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11016834]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]
experiment: EXISTENCE:mutant phenotype:GO:0006033 chitin localization [PMID:33945065]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:27246500]
note: GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars
codon start: 1
product: Ncw2p
translation: MKACSILFTTLITLAAAQKDSGSLDGQNSEDSSQKESSNSQEITPTTTKEAQESASTVVSTGKSLVQTSNVVSNTYAVAPSTTVVTTDAQGKTTTQYLWWVAESNSAVSTTSTASVQPTGETSSGITNSASSSTTSTSTDGPVTIVTTTNSLGETYTSTVWWLPSSATTDNTASSSKSSSGSSSKPESSTKVVSTIKSTYTTTSGSTVETLTTTYKSTVNGKVASVMSNSTNGAFAGTHIAYGAGAFAVGALLL
SIO_010081: YLR194C
subclass of: SO_0000673
so part of: YLR194C
location: complement(540809..541573)
location: region:540809-541573:-1
so has part: feature:540809-541573:-1:exon

NP_013295.1
type: Protein
SIO_000068: ncbiprotein

S000004184
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540809-541573:-1:exon

YLR195C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC72
gene: NMT1
locus tag: YLR195C
gene synonym: CDC72
so part of: sequence
location: complement(<541937..>543304)
location: region:541937-543304:-1
so has part: feature:541937-543304:-1:exon
subclass of: SO_0000010

850892
type: Gene
SIO_000068: ncbigene

position:541937:-1
position: 541937
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:543304:-1
position: 543304
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541937-543304:-1:exon

YLR195C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC72
gene: NMT1
locus tag: YLR195C
gene synonym: CDC72
product: glycylpeptide N-tetradecanoyltransferase NMT1
transcript id: NM_001182082.1
SIO_010081: YLR195C
subclass of: SO_0000673
so part of: YLR195C
location: complement(<541937..>543304)
location: region:541937-543304:-1
so has part: feature:541937-543304:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:541937-543304:-1:exon

YLR195C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC72
gene: NMT1
locus tag: YLR195C
gene synonym: CDC72
EC number: 2.3.1.97
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1544917]
experiment: EXISTENCE:mutant phenotype:GO:0004379 glycylpeptide N-tetradecanoyltransferase activity [PMID:8955162]
note: N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
codon start: 1
product: glycylpeptide N-tetradecanoyltransferase NMT1
translation: MSEEDKAKKLENLLKLLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
SIO_010081: YLR195C
subclass of: SO_0000673
so part of: YLR195C
location: complement(541937..543304)
location: region:541937-543304:-1
so has part: feature:541937-543304:-1:exon

NP_013296.1
type: Protein
SIO_000068: ncbiprotein

S000004185
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541937-543304:-1:exon

YLR196W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PWP1
locus tag: YLR196W
so part of: sequence
location: <543968..>545698
location: region:543968-545698:1
so has part: feature:543968-545698:1:exon
subclass of: SO_0000010

850893
type: Gene
SIO_000068: ncbigene

position:543968:1
position: 543968
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:545698:1
position: 545698
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:543968-545698:1:exon

YLR196W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PWP1
locus tag: YLR196W
product: rRNA-processing protein PWP1
transcript id: NM_001182083.1
SIO_010081: YLR196W
subclass of: SO_0000673
so part of: YLR196W
location: <543968..>545698
location: region:543968-545698:1
so has part: feature:543968-545698:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:543968-545698:1:exon

YLR196W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PWP1
locus tag: YLR196W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15588312]
note: Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
codon start: 1
product: rRNA-processing protein PWP1
translation: MISATNWVPRGFSSEFPEKYVLDDEEVERINQLAQLNLDDAKATLEEAEGESGVEDDAATGSSNKLKDQLDIDDDLKEYNLEEYDDEEIADNEGGKDVSMFPGLSNDSDVKFHEGEKGEDPYISLPNQEDSQEEKQELQVYPSDNLVLAARTEDDVSYLDIYVYDDGAGFHSSDIPVEEGDEADPDVARGLVRDPALYVHHDLMLPAFPLCVEWLDYKVGSNSEEAANYAAIGTFDPQIEIWNLDCVDKAFPDMILGEPLDNSMVSLKSKKKKKKSKTGHITTHHTDAVLSMAHNKYFRSVLASTSADHTVKLWDLNSGNAARSLASIHSNKNVSSSEWHMLNGSILLTGGYDSRVALTDVRISDESQMSKYWSAMAGEEIETVTFASENIILCGTDSGNVYSFDIRNNENRKPVWTLKAHDAGISTLCSNKFIPGMMSTGAMGEKTVKLWKFPLDDATNTKGPSMVLSRDFDVGNVLTSSFAPDIEVAGTMVIGGVNKVLKLWDVFTNRSVRKSFKSELENVQARAKEEAQKIGKSSRIARKYTSNDNPDTVITIDDQGEDEEEREGGDEHDDMA
SIO_010081: YLR196W
subclass of: SO_0000673
so part of: YLR196W
location: 543968..545698
location: region:543968-545698:1
so has part: feature:543968-545698:1:exon

NP_013297.1
type: Protein
SIO_000068: ncbiprotein

S000004186
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:543968-545698:1:exon

YLR197W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SIK1
gene: NOP56
locus tag: YLR197W
gene synonym: SIK1
so part of: sequence
location: <546097..>547611
location: region:546097-547611:1
so has part: feature:546097-547611:1:exon
subclass of: SO_0000010

850894
type: Gene
SIO_000068: ncbigene

position:546097:1
position: 546097
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547611:1
position: 547611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546097-547611:1:exon

YLR197W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SIK1
gene: NOP56
locus tag: YLR197W
gene synonym: SIK1
product: snoRNP complex protein NOP56
transcript id: NM_001182084.1
SIO_010081: YLR197W
subclass of: SO_0000673
so part of: YLR197W
location: <546097..>547611
location: region:546097-547611:1
so has part: feature:546097-547611:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546097-547611:1:exon

YLR197W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SIK1
gene: NOP56
locus tag: YLR197W
gene synonym: SIK1
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9372940|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0031428 box C/D RNP complex [PMID:11081632]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10733567]
experiment: EXISTENCE:physical interaction:GO:0031428 box C/D RNP complex [PMID:10733567]
note: Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
codon start: 1
product: snoRNP complex protein NOP56
translation: MAPIEYLLFEEPTGYAVFKVKLQQDDIGSRLKEVQEQINDFGAFTKLIELVSFAPFKGAAEALENANDISEGLVSESLKAILDLNLPKASSKKKNITLAISDKNLGPSIKEEFPYVDCISNELAQDLIRGVRLHGEKLFKGLQSGDLERAQLGLGHAYSRAKVKFSVQKNDNHIIQAIALLDQLDKDINTFAMRVKEWYGWHFPELAKLVPDNYTFAKLVLFIKDKASLNDDSLHDLAALLNEDSGIAQRVIDNARISMGQDISETDMENVCVFAQRVASLADYRRQLYDYLCEKMHTVAPNLSELIGEVIGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSGFISKASAKNKGRISRYLANKCSMASRIDNYSEEPSNVFGSVLKKQVEQRLEFYNTGKPTLKNELAIQEAMELYNKDKPAAEVEETKEKESSKKRKLEDDDEEKKEKKEKKSKKEKKEKKEKKDKKEKKDKKEKKDKKKKSKD
SIO_010081: YLR197W
subclass of: SO_0000673
so part of: YLR197W
location: 546097..547611
location: region:546097-547611:1
so has part: feature:546097-547611:1:exon

NP_013298.1
type: Protein
SIO_000068: ncbiprotein

S000004187
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546097-547611:1:exon

YLR199C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: POC1
gene: PBA1
locus tag: YLR199C
gene synonym: POC1
so part of: sequence
location: complement(<547853..>548769)
location: region:547853-548769:-1
so has part: feature:547853-548769:-1:exon
subclass of: SO_0000010

850896
type: Gene
SIO_000068: ncbigene

position:547853:-1
position: 547853
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:548769:-1
position: 548769
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547853-548769:-1:exon

YLR199C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: POC1
gene: PBA1
locus tag: YLR199C
gene synonym: POC1
product: Pba1p
transcript id: NM_001182086.1
SIO_010081: YLR199C
subclass of: SO_0000673
so part of: YLR199C
location: complement(join(<547853..548677,548764..>548769))
location: region:547853-548769:-1
so has part: feature:548764-548769:-1:exon
so has part: feature:547853-548677:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548764-548769:-1:exon

position:548764:-1
position: 548764
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:547853-548677:-1:exon

position:548677:-1
position: 548677
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR199C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: POC1
gene: PBA1
locus tag: YLR199C
gene synonym: POC1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17431397]
note: Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
codon start: 1
product: Pba1p
translation: MLFKQWNDLPEPKHLLDLPEISKNLQSLEVCPVPKVEFPQDLDVPQYSTAVITTKIMNPLFPKNLLQLTSIGEIKTTLTVKSPSLPQSSGKHSWNYDENFPNEVDPDQKNDTADETVYGFSFPIYSFGKTLLFSMEENFISISPIFGNMISRSIISQLAQFSPDIIVIGTSDKIASMKVMTENECTLQPPEFITGFIGSVLTQLIVGPSKGLKFKCLVAPSEGPNGFEKLSLSDMGSLVDLCGQWLGFEPSRYSEECYRLWRCDSAAIGAQSGLYI
SIO_010081: YLR199C
subclass of: SO_0000673
so part of: YLR199C
location: complement(join(547853..548677,548764..548769))
location: region:547853-548769:-1
so has part: feature:548764-548769:-1:exon
so has part: feature:547853-548677:-1:exon

NP_013300.2
type: Protein
SIO_000068: ncbiprotein

S000004189
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548764-548769:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:547853-548677:-1:exon

YLR200W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GIM1
alternative label: PFD6
gene: YKE2
locus tag: YLR200W
gene synonym: GIM1; PFD6
so part of: sequence
location: <549012..>549356
location: region:549012-549356:1
so has part: feature:549012-549356:1:exon
subclass of: SO_0000010

850897
type: Gene
SIO_000068: ncbigene

position:549012:1
position: 549012
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549356:1
position: 549356
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549012-549356:1:exon

YLR200W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GIM1
alternative label: PFD6
gene: YKE2
locus tag: YLR200W
gene synonym: GIM1; PFD6
product: tubulin-binding prefolding complex subunit YKE2
transcript id: NM_001182087.1
SIO_010081: YLR200W
subclass of: SO_0000673
so part of: YLR200W
location: <549012..>549356
location: region:549012-549356:1
so has part: feature:549012-549356:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549012-549356:1:exon

YLR200W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GIM1
alternative label: PFD6
gene: YKE2
locus tag: YLR200W
gene synonym: GIM1; PFD6
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:24068951]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]
experiment: EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9463374]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]
experiment: EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]
note: Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
codon start: 1
product: tubulin-binding prefolding complex subunit YKE2
translation: MSELGAKYQQLQNELEEFIVARQKLETQLQENKIVNEEFDQLEEDTPVYKLTGNVLLPVEQSEARTNVDKRLEFIETEITRCEKNIRDKQEELEKMRSELIKLNNTAASTGPGR
SIO_010081: YLR200W
subclass of: SO_0000673
so part of: YLR200W
location: 549012..549356
location: region:549012-549356:1
so has part: feature:549012-549356:1:exon

NP_013301.1
type: Protein
SIO_000068: ncbiprotein

S000004190
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549012-549356:1:exon

YLR201C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COQ9
locus tag: YLR201C
so part of: sequence
location: complement(<549511..>550293)
location: region:549511-550293:-1
so has part: feature:549511-550293:-1:exon
subclass of: SO_0000010

850898
type: Gene
SIO_000068: ncbigene

position:549511:-1
position: 549511
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550293:-1
position: 550293
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549511-550293:-1:exon

YLR201C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COQ9
locus tag: YLR201C
product: ubiquinone biosynthesis protein COQ9
transcript id: NM_001182088.1
SIO_010081: YLR201C
subclass of: SO_0000673
so part of: YLR201C
location: complement(<549511..>550293)
location: region:549511-550293:-1
so has part: feature:549511-550293:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549511-550293:-1:exon

YLR201C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COQ9
locus tag: YLR201C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:17391640|PMID:16027161]
experiment: EXISTENCE:mutant phenotype:GO:1901006 ubiquinone-6 biosynthetic process [PMID:16027161]
experiment: EXISTENCE:physical interaction:GO:0006744 ubiquinone biosynthetic process [PMID:17391640]
note: Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant
codon start: 1
product: ubiquinone biosynthesis protein COQ9
translation: MLCRNTARTGCKFFRLYHSNPIEHVKPIHIKPLTYGKESPQYKVLSLALQKFVPEHGFSERSIVESLNELGYPSSMISSIGAPNSPSFFHSSTAVMELIKFQLVDKRYRLTEGINPDVTPQYKLPSLEHLLLKRLEMDKPIGGHLSELMSQLAIPSAFLFETAIPELHRLSDDMIYFSNEKDHHDSAWYAKRLAVSSTYIGSKLFMAQDKSHNYKETFTFAKDKLHRVMRLGEYYNNTEEFAWYTLMSTVNLIKSQLVRG
SIO_010081: YLR201C
subclass of: SO_0000673
so part of: YLR201C
location: complement(549511..550293)
location: region:549511-550293:-1
so has part: feature:549511-550293:-1:exon

NP_013302.1
type: Protein
SIO_000068: ncbiprotein

S000004191
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549511-550293:-1:exon

YLR203C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSS51
locus tag: YLR203C
so part of: sequence
location: complement(<550650..>551960)
location: region:550650-551960:-1
so has part: feature:550650-551960:-1:exon
subclass of: SO_0000010

850900
type: Gene
SIO_000068: ncbigene

position:550650:-1
position: 550650
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551960:-1
position: 551960
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:550650-551960:-1:exon

YLR203C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSS51
locus tag: YLR203C
product: Mss51p
transcript id: NM_001182090.1
SIO_010081: YLR203C
subclass of: SO_0000673
so part of: YLR203C
location: complement(<550650..>551960)
location: region:550650-551960:-1
so has part: feature:550650-551960:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:550650-551960:-1:exon

YLR203C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSS51
locus tag: YLR203C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:24769239|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:15306853]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:15306853]
experiment: EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:19710419]
experiment: EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:15306853|PMID:19710419]
experiment: EXISTENCE:physical interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:15306853]
note: Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis
codon start: 1
product: Mss51p
translation: MTVLYAPSGATQLYFHLLRKSPHNRLVVSHQTRRHLMGFVRNALGLDPPPSPEDPTPENRFHPWDQSPSVDLRERAAKIRTLAHCPVTGKDINYTCPLSGIPTHHSREAWEMDKAYHDSKKYEILKKVNIYEHDLRSGRPFPEFDFPQQQGYDKAVNLTNWDLFFYTRSFYSMDTEFQLAAVTKMLSYPITIGSLLHKFSPYSLNPKGPITLEGLKSLAALRYTLYPLENRSLPTTTKNRAMRIFILGARAEAQLPGHVWKQLQFLFPEQSFEIHFIGPECLYKRDKQEYVKSTTPVVQRVDETLKFIYRTNFFEVFHEAQDFFPYDPYMDVFFTFHPGYASPESHGSWMGETMKALLETKCAIFTTGFNKKDLTDDINLVKSKYGKEMDVLMEPVRNVFGSTKWELNDMNPQEVYQFNMYIAGFRGKRYHTIKRQ
SIO_010081: YLR203C
subclass of: SO_0000673
so part of: YLR203C
location: complement(550650..551960)
location: region:550650-551960:-1
so has part: feature:550650-551960:-1:exon

NP_013304.1
type: Protein
SIO_000068: ncbiprotein

S000004193
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:550650-551960:-1:exon

YLR204W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COX24
alternative label: mS38
gene: QRI5
locus tag: YLR204W
gene synonym: COX24; mS38
so part of: sequence
location: <552270..>552605
location: region:552270-552605:1
so has part: feature:552270-552605:1:exon
subclass of: SO_0000010

850901
type: Gene
SIO_000068: ncbigene

position:552270:1
position: 552270
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552605:1
position: 552605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552270-552605:1:exon

YLR204W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COX24
alternative label: mS38
gene: QRI5
locus tag: YLR204W
gene synonym: COX24; mS38
product: Qri5p
transcript id: NM_001182091.1
SIO_010081: YLR204W
subclass of: SO_0000673
so part of: YLR204W
location: <552270..>552605
location: region:552270-552605:1
so has part: feature:552270-552605:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552270-552605:1:exon

YLR204W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COX24
alternative label: mS38
gene: QRI5
locus tag: YLR204W
gene synonym: COX24; mS38
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16339141]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:16339141]
experiment: EXISTENCE:mutant phenotype:GO:0061668 mitochondrial ribosome assembly [PMID:30968120]
experiment: EXISTENCE:mutant phenotype:GO:0070124 mitochondrial translational initiation [PMID:30968120]
note: Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
codon start: 1
product: Qri5p
translation: MLGRALRPGWLGITRTVVKKPSCGSYFNRTFQTAINTTMPPMQEGMLSTMMMMTATATRITGTVSEPLNGSNIVMQLDSVMRKRKKKMKKHKLRKRRKREKAERRKLSQGR
SIO_010081: YLR204W
subclass of: SO_0000673
so part of: YLR204W
location: 552270..552605
location: region:552270-552605:1
so has part: feature:552270-552605:1:exon

NP_013305.1
type: Protein
SIO_000068: ncbiprotein

S000004194
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552270-552605:1:exon

YLR205C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HMX1
locus tag: YLR205C
so part of: sequence
location: complement(<552724..>553677)
location: region:552724-553677:-1
so has part: feature:552724-553677:-1:exon
subclass of: SO_0000010

850902
type: Gene
SIO_000068: ncbigene

position:552724:-1
position: 552724
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:553677:-1
position: 553677
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552724-553677:-1:exon

YLR205C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HMX1
locus tag: YLR205C
product: Hmx1p
transcript id: NM_001182092.1
SIO_010081: YLR205C
subclass of: SO_0000673
so part of: YLR205C
location: complement(<552724..>553677)
location: region:552724-553677:-1
so has part: feature:552724-553677:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552724-553677:-1:exon

YLR205C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HMX1
locus tag: YLR205C
experiment: EXISTENCE:direct assay:GO:0004392 heme oxygenase (decyclizing) activity [PMID:17144670]
experiment: EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:21081499]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12840010]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:11566881]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:12840010]
experiment: EXISTENCE:mutant phenotype:GO:0006979 response to oxidative stress [PMID:21081499]
experiment: EXISTENCE:mutant phenotype:GO:0042167 heme catabolic process [PMID:12840010]
note: ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
codon start: 1
product: Hmx1p
translation: MEDSSNTIIPSPTDVGALANRINFQTRDAHNKINTFMGIKMAIAMRHGFIYRQGILAYYYVFDAIEQEIDRLLNDPVTEEELQTSTILKQFWLEDFRRSTQIYKDLKLLYSNTFKSTESLNEFLATFQKPPLLQQFINNIHENIHKEPCTILSYCHVLYLALFAGGKLIRSNLYRRLGLFPNFEKLSQKELVKKGTNFFTFSDLGPTEETRLKWEYKKNYELATRTELTEAQKLQIISVAEGIFDWNFNIVAEIGELNRRELMGKFSFKCITYLYEEWMFNKDSATRRALHTVMLLVLSIIAIWVLYFLVKSFLSIV
SIO_010081: YLR205C
subclass of: SO_0000673
so part of: YLR205C
location: complement(552724..553677)
location: region:552724-553677:-1
so has part: feature:552724-553677:-1:exon

NP_013306.2
type: Protein
SIO_000068: ncbiprotein

S000004195
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552724-553677:-1:exon

YLR206W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENT2
locus tag: YLR206W
so part of: sequence
location: <554578..>556419
location: region:554578-556419:1
so has part: feature:554578-556419:1:exon
subclass of: SO_0000010

850903
type: Gene
SIO_000068: ncbigene

position:554578:1
position: 554578
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556419:1
position: 556419
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554578-556419:1:exon

YLR206W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENT2
locus tag: YLR206W
product: epsin
transcript id: NM_001182093.1
SIO_010081: YLR206W
subclass of: SO_0000673
so part of: YLR206W
location: <554578..>556419
location: region:554578-556419:1
so has part: feature:554578-556419:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554578-556419:1:exon

YLR206W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENT2
locus tag: YLR206W
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:10449404]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10449404]
experiment: EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10449404]
note: Epsin-like protein required for endocytosis and actin patch assembly; K48-, K63-specific Ub chain binding protein that functions as an endocytic adaptor; contains clathrin-binding motif at C-terminus; functionally redundant with Ent1p; ENT2 has a paralog, ENT1, that arose from the whole genome duplication
codon start: 1
product: epsin
translation: MSKQFVRSAKNMMKGYSSTQVLVRDATANDSRTPSIDTLDDLAQRSYDSVDFFEIMDMLDKRLNDKGKYWRHVAKSLTVLDYLVRFGSENCVLWCRENFYVIKTLREFRHENESGFDEGQIIRVKAKELVSLLNDEERLREERSMNTRNRRANRAARPRPRRQRTRSNPHDSSPSYQDDLEKALEESRITAQEDEQRRRELAQYDDEDPDFQAALQLSKEEEELKQLQELQRLQKQQQSLSQFQAPLQQQQPQQQPAYYDIFGNPISQDEYLQYQYQQDQEQAMAQQRWLDQQQEQQQLAEQQYFQQQQQAAAAASALQQQQTAANMQQQQQQPADFQQPLPTGSNNPFSMDNLERQKQEQQHAQLQRQQEEARQQQEQLKLQQLQRQQQEEAQLHQKRQEEAQLQQQQAQLLQQQAQFQQQQPLKQTRTGNQSISDKYSDLNTLLATGTGIDTFGNTGEARIPAQHTKTGTFINSQGTGYKQVTNEPKNNPFLSNQYTGLPSTNIVPTQTGYGFGNQPQSPPTNSPQQNPTGISYSQPQQQQQPQQQPQYMQNFQQQQPQYAQNFQQQPQYTQNYQQQPQYIQPHQQQQQQQQQQQQQQGYTPDQGVSLIDL
SIO_010081: YLR206W
subclass of: SO_0000673
so part of: YLR206W
location: 554578..556419
location: region:554578-556419:1
so has part: feature:554578-556419:1:exon

NP_013307.1
type: Protein
SIO_000068: ncbiprotein

S000004196
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554578-556419:1:exon

YLR207W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HRD3
locus tag: YLR207W
so part of: sequence
location: <556788..>559289
location: region:556788-559289:1
so has part: feature:556788-559289:1:exon
subclass of: SO_0000010

850904
type: Gene
SIO_000068: ncbigene

position:556788:1
position: 556788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:559289:1
position: 559289
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:556788-559289:1:exon

YLR207W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HRD3
locus tag: YLR207W
product: ubiquitin ligase complex subunit HRD3
transcript id: NM_001182094.1
SIO_010081: YLR207W
subclass of: SO_0000673
so part of: YLR207W
location: <556788..>559289
location: region:556788-559289:1
so has part: feature:556788-559289:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:556788-559289:1:exon

YLR207W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HRD3
locus tag: YLR207W
experiment: EXISTENCE:direct assay:GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11390656]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:12105183]
experiment: EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]
experiment: EXISTENCE:direct assay:GO:1905524 negative regulation of protein autoubiquitination [PMID:31713515]
experiment: EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]
experiment: EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:16619026]
note: ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events
codon start: 1
product: ubiquitin ligase complex subunit HRD3
translation: MITLLLYLCVICNAIVLIRADSIADPWPEARHLLNTIAKSRDPMKEAAMEPNADEFVGFYVPMDYSPRNEEKNYQSIWQNEITDSQRHIYELLVQSSEQFNNSEATYTLSQIHLWSQYNFPHNMTLAHKYLEKFNDLTHFTNHSAIFDLAVMYATGGCASGNDQTVIPQDSAKALLYYQRAAQLGNLKAKQVLAYKYYSGFNVPRNFHKSLVLYRDIAEQLRKSYSRDEWDIVFPYWESYNVRISDFESGLLGKGLNSVPSSTVRKRTTRPDIGSPFIAQVNGVQMTLQIEPMGRFAFNGNDGNINGDEDDEDASERRIIRIYYAALNDYKGTYSQSRNCERAKNLLELTYKEFQPHVDNLDPLQVFYYVRCLQLLGHMYFTGEGSSKPNIHMAEEILTTSLEISRRAQGPIGRACIDLGLINQYITNNISQAISYYMKAMKTQANNGIVEFQLSKLATSFPEEKIGDPFNLMETAYLNGFIPAIYEFAVMIESGMNSKSSVENTAYLFKTFVDKNEAIMAPKLRTAFAALINDRSEVALWAYSQLAEQGYETAQVSAAYLMYQLPYEFEDPPRTTDQRKTLAISYYTRAFKQGNIDAGVVAGDIYFQMQNYSKAMALYQGAALKYSIQAIWNLGYMHEHGLGVNRDFHLAKRYYDQVSEHDHRFYLASKLSVLKLHLKSWLTWITREKVNYWKPSSPLNPNEDTQHSKTSWYKQLTKILQRMRHKEDSDKAAEDSHKHRTVVQNGANHRGDDQEEASEILGFQMEDLVTMGCILGIFLLSILMSTLAARRGWNVRFNGAQLNANGNRQQEQQQQQQAQGPPGWDFNVQIFAI
SIO_010081: YLR207W
subclass of: SO_0000673
so part of: YLR207W
location: 556788..559289
location: region:556788-559289:1
so has part: feature:556788-559289:1:exon

NP_013308.1
type: Protein
SIO_000068: ncbiprotein

S000004197
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:556788-559289:1:exon

YLR208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ANU3
gene: SEC13
locus tag: YLR208W
gene synonym: ANU3
so part of: sequence
location: <559551..>560444
location: region:559551-560444:1
so has part: feature:559551-560444:1:exon
subclass of: SO_0000010

850905
type: Gene
SIO_000068: ncbigene

position:559551:1
position: 559551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560444:1
position: 560444
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559551-560444:1:exon

YLR208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ANU3
gene: SEC13
locus tag: YLR208W
gene synonym: ANU3
product: GTPase-activating protein SEC13
transcript id: NM_001182095.1
SIO_010081: YLR208W
subclass of: SO_0000673
so part of: YLR208W
location: <559551..>560444
location: region:559551-560444:1
so has part: feature:559551-560444:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559551-560444:1:exon

YLR208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ANU3
gene: SEC13
locus tag: YLR208W
gene synonym: ANU3
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12671686|PMID:17604721]
experiment: EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:11717432|PMID:8004676]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:11389436]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:22300850]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:12538638]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:10747086]
experiment: EXISTENCE:mutant phenotype:GO:0090114 COPII-coated vesicle budding [PMID:8223424|PMID:8432727]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:23974112]
note: Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog
codon start: 1
product: GTPase-activating protein SEC13
translation: MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ
SIO_010081: YLR208W
subclass of: SO_0000673
so part of: YLR208W
location: 559551..560444
location: region:559551-560444:1
so has part: feature:559551-560444:1:exon

NP_013309.1
type: Protein
SIO_000068: ncbiprotein

S000004198
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559551-560444:1:exon

YLR209C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PNP1
locus tag: YLR209C
so part of: sequence
location: complement(<560797..>561732)
location: region:560797-561732:-1
so has part: feature:560797-561732:-1:exon
subclass of: SO_0000010

850906
type: Gene
SIO_000068: ncbigene

position:560797:-1
position: 560797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:561732:-1
position: 561732
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560797-561732:-1:exon

YLR209C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PNP1
locus tag: YLR209C
product: purine-nucleoside phosphorylase
transcript id: NM_001182096.1
SIO_010081: YLR209C
subclass of: SO_0000673
so part of: YLR209C
location: complement(<560797..>561732)
location: region:560797-561732:-1
so has part: feature:560797-561732:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560797-561732:-1:exon

YLR209C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PNP1
locus tag: YLR209C
EC number: 2.4.2.1
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:17482543]
experiment: EXISTENCE:direct assay:GO:0004731 purine-nucleoside phosphorylase activity [PMID:11466296]
experiment: EXISTENCE:direct assay:GO:0047724 inosine nucleosidase activity [PMID:19001417]
experiment: EXISTENCE:direct assay:GO:0070635 nicotinamide riboside hydrolase activity [PMID:19001417]
experiment: EXISTENCE:genetic interaction:GO:0019358 nicotinate nucleotide salvage [PMID:17482543]
experiment: EXISTENCE:genetic interaction:GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway [PMID:19001417]
experiment: EXISTENCE:mutant phenotype:GO:0004731 purine-nucleoside phosphorylase activity [PMID:11466296]
experiment: EXISTENCE:mutant phenotype:GO:0006148 inosine catabolic process [PMID:11466296|PMID:23670538]
experiment: EXISTENCE:mutant phenotype:GO:0046115 guanosine catabolic process [PMID:11466296|PMID:23670538]
note: Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
codon start: 1
product: purine-nucleoside phosphorylase
translation: MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL
SIO_010081: YLR209C
subclass of: SO_0000673
so part of: YLR209C
location: complement(560797..561732)
location: region:560797-561732:-1
so has part: feature:560797-561732:-1:exon

NP_013310.1
type: Protein
SIO_000068: ncbiprotein

S000004199
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560797-561732:-1:exon

YLR210W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CLB4
locus tag: YLR210W
so part of: sequence
location: <562008..>563390
location: region:562008-563390:1
so has part: feature:562008-563390:1:exon
subclass of: SO_0000010

850907
type: Gene
SIO_000068: ncbigene

position:562008:1
position: 562008
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:563390:1
position: 563390
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:562008-563390:1:exon

YLR210W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CLB4
locus tag: YLR210W
product: B-type cyclin CLB4
transcript id: NM_001182097.1
SIO_010081: YLR210W
subclass of: SO_0000673
so part of: YLR210W
location: <562008..>563390
location: region:562008-563390:1
so has part: feature:562008-563390:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:562008-563390:1:exon

YLR210W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CLB4
locus tag: YLR210W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:11438663|PMID:1387566|PMID:16688214]
experiment: EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]
experiment: EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:8455600]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:1427070]
experiment: EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8455600]
note: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication
codon start: 1
product: B-type cyclin CLB4
translation: MMLEGYTVQPPQSTLIGDIEIQDENANQEVKNVLYQGVQKGIKRLEKRQRRVALGDVTSQKANKIHNAIHNKFHQTKNNFEIENIRSSALVKEQQRDVRHEDSDYFLIDSSEGSSTDDEQVNEDAIDDLLSRRVNDQQIQADEVYEDFDGEMQDVIEEDVDSQIEPLSPINNDEIQTELDRAFEKYFRSVPNPLDDDTHDVVMVVEYASDIFYYLRELEVKYRPNPYYMQNQVELTWPFRRTMIDWLVQLHFRFQLLPETLYLTINIVDRFLSKKTVTLNRFQLVGVSALFIAAKFEEINCPTLDDLVYMLENTYTRDDIIRAEQYMIDTLEFEIGWPGPMPFLRRISKADDYDFEPRTLAKYLLETTIVEPKLVAAAPSWLAAGAYFLSRTILGSNDWSLKHVFYSGYTSSQIIPLASLILENCKNASRRHHSIWKKYFDQKHYRCSQIVEEWIVSTEA
SIO_010081: YLR210W
subclass of: SO_0000673
so part of: YLR210W
location: 562008..563390
location: region:562008-563390:1
so has part: feature:562008-563390:1:exon

NP_013311.1
type: Protein
SIO_000068: ncbiprotein

S000004200
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:562008-563390:1:exon

YLR211C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATG38
locus tag: YLR211C
so part of: sequence
location: complement(<563792..>564531)
location: region:563792-564531:-1
so has part: feature:563792-564531:-1:exon
subclass of: SO_0000010

850908
type: Gene
SIO_000068: ncbigene

position:563792:-1
position: 563792
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:564531:-1
position: 564531
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:563792-564531:-1:exon

YLR211C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATG38
locus tag: YLR211C
product: Atg38p
transcript id: NM_001182098.1
SIO_010081: YLR211C
subclass of: SO_0000673
so part of: YLR211C
location: complement(join(<563792..564454,564514..>564531))
location: region:563792-564531:-1
so has part: feature:564514-564531:-1:exon
so has part: feature:563792-564454:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:564514-564531:-1:exon

position:564514:-1
position: 564514
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:563792-564454:-1:exon

position:564454:-1
position: 564454
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR211C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATG38
locus tag: YLR211C
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:24165940]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:24165940]
experiment: EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:24165940]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:24165940]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:24165940]
note: Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy
codon start: 1
product: Atg38p
translation: MSTLAEVYTIIEDAEQECRKGDFTNAKAKYQEAIEVLGPQNENLSQNKLSSDVTQAIDLLKQDITAKIQELELLIEKQSSEENNIGMVNNNMLIGSVILNNKSPINGISNARNWDNPAYQDTLSPINDPLLMSILNRLQFNLNNDIQLKTEGGKNSKNSEMKINLRLEQFKKELVLYEQKKFKEYGMKIDEITKENKKLANEIGRLRERWDSLVESAKQRRDKQKN
SIO_010081: YLR211C
subclass of: SO_0000673
so part of: YLR211C
location: complement(join(563792..564454,564514..564531))
location: region:563792-564531:-1
so has part: feature:564514-564531:-1:exon
so has part: feature:563792-564454:-1:exon

NP_013312.2
type: Protein
SIO_000068: ncbiprotein

S000004201
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:564514-564531:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:563792-564454:-1:exon

YLR212C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TUB4
locus tag: YLR212C
so part of: sequence
location: complement(<564860..>566281)
location: region:564860-566281:-1
so has part: feature:564860-566281:-1:exon
subclass of: SO_0000010

850909
type: Gene
SIO_000068: ncbigene

position:564860:-1
position: 564860
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:566281:-1
position: 566281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:564860-566281:-1:exon

YLR212C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TUB4
locus tag: YLR212C
product: gamma-tubulin
transcript id: NM_001182099.1
SIO_010081: YLR212C
subclass of: SO_0000673
so part of: YLR212C
location: complement(<564860..>566281)
location: region:564860-566281:-1
so has part: feature:564860-566281:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:564860-566281:-1:exon

YLR212C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TUB4
locus tag: YLR212C
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630]
experiment: EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630]
experiment: EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:11950928|PMID:24842996]
experiment: EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9130700|PMID:9384578|PMID:25599398]
experiment: EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:8557744]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9153752]
experiment: EXISTENCE:mutant phenotype:GO:0051417 microtubule nucleation by spindle pole body [PMID:8707828]
experiment: EXISTENCE:mutant phenotype:GO:2000767 positive regulation of cytoplasmic translation [PMID:26310304]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9130700|PMID:8670895]
experiment: EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]
note: Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1
codon start: 1
product: gamma-tubulin
translation: MGGEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGLSQLPDSSTERDDDTKPFFRENSRNKFTPRAIMMDSEPSVIADVENTFRGFFDPRNTWVASDGASAGNSWANGYDIGTRNQDDILNKIDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYPKKILTTYSVFPARSSEVVVQSYNTILALRRLIEDSDATVVFDNASLLNISGKVFRNPNIDLQHTNQLISTIISSVTNSIRFPSYMYSSMSSIYSTLIPSPELHFLSPSFTPFTSDYIHDDIAHKGHSSYDVMLDLLDPSNSLVSTAMNNPTYFNVYNTIIGNVEPRQISRAMTKLQQRIKFPSWSSSAMHVNIGRRSPYLPLQPNENEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNNYNVGDLFQSMQNVQDEFAESREVVQSLMEDYVAAEQDSYLDDVLVDDENMVGELEEDLDADGDHKLV
SIO_010081: YLR212C
subclass of: SO_0000673
so part of: YLR212C
location: complement(564860..566281)
location: region:564860-566281:-1
so has part: feature:564860-566281:-1:exon

NP_013313.1
type: Protein
SIO_000068: ncbiprotein

S000004202
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:564860-566281:-1:exon

YLR213C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRR1
locus tag: YLR213C
so part of: sequence
location: complement(<566654..>567922)
location: region:566654-567922:-1
so has part: feature:566654-567922:-1:exon
subclass of: SO_0000010

850910
type: Gene
SIO_000068: ncbigene

position:566654:-1
position: 566654
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:567922:-1
position: 567922
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566654-567922:-1:exon

YLR213C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRR1
locus tag: YLR213C
product: putative glycosylase
transcript id: NM_001182100.1
SIO_010081: YLR213C
subclass of: SO_0000673
so part of: YLR213C
location: complement(<566654..>567922)
location: region:566654-567922:-1
so has part: feature:566654-567922:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:566654-567922:-1:exon

YLR213C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRR1
locus tag: YLR213C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:15470107]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15470107]
note: Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
codon start: 1
product: putative glycosylase
translation: MRISILQLVPVVGYIGFALGELYKPKNSISCSPNNPCPAEWPCCSPYNECGAGPICVGGCNVRSSFDEESCAPIPALVASQKLEFVSTPKVPKFIVNYQPKPPIREGNGPNKANTKVGVVEGELNSKRIIHYAKFLVTPDSKEAEKMLEDFDFTHSGYTSIEASSGNIVLAMPKKTTGSLITSTRSFLYGKASVRMKTARSRGVVTAFDLTSAIGDEIDFEWLGGDLMTAQSNYYSQGHLDYTRMQRFPVGADTWATYHTYEIDWDPDRIIWYVDGKIARTVLKKDTWDPISKEYRYPQTPMRLEIAVWPGGSETNGPGTINWAGGLIDWENSPDIIEKGQFTAHVEQITVTPYQNKFTEQVQFCIKAKKKAPTFSQKDLSRVVVSYNRQDRLNHHDEGSLKWDCFVTPKINDWLSSWKRSK
SIO_010081: YLR213C
subclass of: SO_0000673
so part of: YLR213C
location: complement(566654..567922)
location: region:566654-567922:-1
so has part: feature:566654-567922:-1:exon

NP_013314.1
type: Protein
SIO_000068: ncbiprotein

S000004203
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566654-567922:-1:exon

YLR214W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRE1
locus tag: YLR214W
so part of: sequence
location: <568567..>570627
location: region:568567-570627:1
so has part: feature:568567-570627:1:exon
subclass of: SO_0000010

850911
type: Gene
SIO_000068: ncbigene

position:568567:1
position: 568567
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:570627:1
position: 570627
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568567-570627:1:exon

YLR214W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRE1
locus tag: YLR214W
product: ferric/cupric-chelate reductase
transcript id: NM_001182101.1
SIO_010081: YLR214W
subclass of: SO_0000673
so part of: YLR214W
location: <568567..>570627
location: region:568567-570627:1
so has part: feature:568567-570627:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:568567-570627:1:exon

YLR214W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRE1
locus tag: YLR214W
EC number: 1.16.1.9
experiment: EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:8164662]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8164662|PMID:17507646]
experiment: EXISTENCE:direct assay:GO:0006826 iron ion transport [PMID:8164662]
experiment: EXISTENCE:direct assay:GO:0015677 copper ion import [PMID:7814363]
note: Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
codon start: 1
product: ferric/cupric-chelate reductase
translation: MVRTRVLFCLFISFFATVQSSATLISTSCISQAALYQFGCSSKSKSCYCKNINWLGSVTACAYENSKSNKTLDSALMKLASQCSSIKVYTLEDMKNIYLNASNYLRAPEKSDKKTVVSQPLMANETAYHYYYEENYGIHLNLMRSQWCAWGLVFFWVAVLTAATILNILKRVFGKNIMANSVKKSLIYPSVYKDYNERTFYLWKRLPFNFTTRGKGLVVLIFVILTILSLSFGHNIKLPHPYDRPRWRRSMAFVSRRADLMAIALFPVVYLFGIRNNPFIPITGLSFSTFNFYHKWSAYVCFMLAVVHSIVMTASGVKRGVFQSLVRKFYFRWGIVATILMSIIIFQSEKVFRNRGYEIFLLIHKAMNIMFIIAMYYHCHTLGWMGWIWSMAGILCFDRFCRIVRIIMNGGLKTATLSTTDDSNVIKISVKKPKFFKYQVGAFAYMYFLSPKSAWFYSFQSHPFTVLSERHRDPNNPDQLTMYVKANKGITRVLLSKVLSAPNHTVDCKIFLEGPYGVTVPHIAKLKRNLVGVAAGLGVAAIYPHFVECLRLPSTDQLQHKFYWIVNDLSHLKWFENELQWLKEKSCEVSVIYTGSSVEDTNSDESTKGFDDKEESEITVECLNKRPDLKELVRSEIKLSELENNNITFYSCGPATFNDDFRNAVVQGIDSSLKIDVELEEESFTW
SIO_010081: YLR214W
subclass of: SO_0000673
so part of: YLR214W
location: 568567..570627
location: region:568567-570627:1
so has part: feature:568567-570627:1:exon

NP_013315.1
type: Protein
SIO_000068: ncbiprotein

S000004204
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568567-570627:1:exon

YLR215C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC123
locus tag: YLR215C
so part of: sequence
location: complement(<570776..>571858)
location: region:570776-571858:-1
so has part: feature:570776-571858:-1:exon
subclass of: SO_0000010

850912
type: Gene
SIO_000068: ncbigene

position:570776:-1
position: 570776
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:571858:-1
position: 571858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:570776-571858:-1:exon

YLR215C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC123
locus tag: YLR215C
product: cell proliferation protein CDC123
transcript id: NM_001182102.1
SIO_010081: YLR215C
subclass of: SO_0000673
so part of: YLR215C
location: complement(<570776..>571858)
location: region:570776-571858:-1
so has part: feature:570776-571858:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:570776-571858:-1:exon

YLR215C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC123
locus tag: YLR215C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:23775072]
experiment: EXISTENCE:mutant phenotype:GO:1905143 eukaryotic translation initiation factor 2 complex assembly [PMID:23775072|PMID:26211610]
note: Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant
codon start: 1
product: cell proliferation protein CDC123
translation: MSSQEYTTFIDIPVTRAQVEHCSYSFWSSLYPKYVPKSIVLKSLPKKFIQYLEQDGIKLPQEENSRSVYTEEIIRNEDNDYSDWEDDEDTATEFVQEVEPLIDFPELHQKLKDALNELGAVAPKLNWSAPRDATWILPNNTMKCNEVNELYLLLNASNYIMHDLQRAFKGCVDGDDIKGLKFDLVLRQWCDMNPALEFRVFVKNAHIVGATQRDLNYYDYLDELSDTFKDLIDEIVHDVVLPKFPDKSFVLDVYIPRPFNKIFIVDINPFARKTDSLLFSWNEIAAIAPPKNDVEDYELRLVTRHNTGRFASKEHSENHVPQDLVEASLNPEAIRELTQKWKELLSQQAKEESSDSENET
SIO_010081: YLR215C
subclass of: SO_0000673
so part of: YLR215C
location: complement(570776..571858)
location: region:570776-571858:-1
so has part: feature:570776-571858:-1:exon

NP_013316.1
type: Protein
SIO_000068: ncbiprotein

S000004205
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:570776-571858:-1:exon

YLR216C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP40
gene: CPR6
locus tag: YLR216C
gene synonym: CYP40
so part of: sequence
location: complement(<572096..>573211)
location: region:572096-573211:-1
so has part: feature:572096-573211:-1:exon
subclass of: SO_0000010

850914
type: Gene
SIO_000068: ncbigene

position:572096:-1
position: 572096
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573211:-1
position: 573211
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:572096-573211:-1:exon

YLR216C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP40
gene: CPR6
locus tag: YLR216C
gene synonym: CYP40
product: peptidylprolyl isomerase CPR6
transcript id: NM_001182103.1
SIO_010081: YLR216C
subclass of: SO_0000673
so part of: YLR216C
location: complement(<572096..>573211)
location: region:572096-573211:-1
so has part: feature:572096-573211:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:572096-573211:-1:exon

YLR216C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP40
gene: CPR6
locus tag: YLR216C
gene synonym: CYP40
EC number: 5.2.1.8
experiment: EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:10942767|PMID:9191025]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9191025|PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9927435]
experiment: EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:10942767]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:25380751]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10942767]
experiment: EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:9927435]
note: Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress
codon start: 1
product: peptidylprolyl isomerase CPR6
translation: MTRPKTFFDISIGGKPQGRIVFELYNDIVPKTAENFLKLCEGNAGMAKTKPDVPLSYKGSIFHRVIKDFMCQFGDFTNFNGTGGESIYDEKFEDENFTVKHDKPFLLSMANAGPNTNGSQAFITCVPTPHLDGKHVVFGEVIQGKRIVRLIENQQCDQENNKPLRDVKIDDCGVLPDDYQVPENAEATPTDEYGDNYEDVLKQDEKVDLKNFDTVLKAIETVKNIGTEQFKKQNYSVALEKYVKCDKFLKEYFPEDLEKEQIEKINQLKVSIPLNIAICALKLKDYKQVLVASSEVLYAEAADEKAKAKALYRRGLAYYHVNDTDMALNDLEMATTFQPNDAAILKAIHNTKLKRKQQNEKAKKSLSKMFS
SIO_010081: YLR216C
subclass of: SO_0000673
so part of: YLR216C
location: complement(572096..573211)
location: region:572096-573211:-1
so has part: feature:572096-573211:-1:exon

NP_013317.1
type: Protein
SIO_000068: ncbiprotein

S000004206
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:572096-573211:-1:exon

YLR218C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CMC3
gene: COA4
locus tag: YLR218C
gene synonym: CMC3
so part of: sequence
location: complement(<573466..>573918)
location: region:573466-573918:-1
so has part: feature:573466-573918:-1:exon
subclass of: SO_0000010

850915
type: Gene
SIO_000068: ncbigene

position:573466:-1
position: 573466
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573918:-1
position: 573918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:573466-573918:-1:exon

YLR218C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CMC3
gene: COA4
locus tag: YLR218C
gene synonym: CMC3
product: Coa4p
transcript id: NM_001182105.1
SIO_010081: YLR218C
subclass of: SO_0000673
so part of: YLR218C
location: complement(<573466..>573918)
location: region:573466-573918:-1
so has part: feature:573466-573918:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:573466-573918:-1:exon

YLR218C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CMC3
gene: COA4
locus tag: YLR218C
gene synonym: CMC3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19703468|PMID:20624914]
experiment: EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:20624914|PMID:23198688]
experiment: EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:20624914|PMID:23198688]
note: Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4
codon start: 1
product: Coa4p
translation: MLLFSSFFSHNKCPKQKKGPQPLKVVKGTSKSCAKQGKIKGKEKLWQAKTGRLVMSETGETSEYYKQALEEYKEVQEDEDPDVWDTRISKTGCYVENLALQLCHAETGDWRQCFNEMALFRKCWEKNGNRERVSTVDVDGTTSKDSEKKK
SIO_010081: YLR218C
subclass of: SO_0000673
so part of: YLR218C
location: complement(573466..573918)
location: region:573466-573918:-1
so has part: feature:573466-573918:-1:exon

NP_013319.1
type: Protein
SIO_000068: ncbiprotein

S000004208
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:573466-573918:-1:exon

YLR219W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSC3
locus tag: YLR219W
so part of: sequence
location: <574151..>576337
location: region:574151-576337:1
so has part: feature:574151-576337:1:exon
subclass of: SO_0000010

850916
type: Gene
SIO_000068: ncbigene

position:574151:1
position: 574151
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:576337:1
position: 576337
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574151-576337:1:exon

YLR219W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSC3
locus tag: YLR219W
product: Msc3p
transcript id: NM_001182106.1
SIO_010081: YLR219W
subclass of: SO_0000673
so part of: YLR219W
location: <574151..>576337
location: region:574151-576337:1
so has part: feature:574151-576337:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574151-576337:1:exon

YLR219W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSC3
locus tag: YLR219W
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress
codon start: 1
product: Msc3p
translation: MVFGFTKRDRRVPDLSRYDYYYQNHEDYNKSPQLSAAAASAASAASPDRTNYSRSHSLVSHAPSIPRQRSSVKSPGRRLSTSSAAPPTSRAAAKQYSQKTYSLRSQRSGEYHLHPPGYTTNGSRMNSMTSGANVRRNYGKNKSTAGNNNDSRANSITVKTTQVTDPSGRTQSITKKTIRKINGYEYVETTTTTKNLVPLGDSQRHFDEFSENYMLQDDDILEEQASDNIHDIIEENETDNEKPYSPVSESHLQDDSELNVEKPDFPLGSYFHHKYSTDVMPLEEESSLSNFSDALDYIPPTHQTSSKYIHNKRKQASTTRRKKRPPAVKNAEAEAKKPLTEAEMYLKALEVAKRNVYHTDAASDNASAPLGSNKSRKSRMGQKMTLRSSSDSPTATANLVKSNVEVQPKRFTSSFFSRNTKSAPHEVHNHSVSTHFKSNKAVDPVPEPKSANTGLTDKEMYDQALKIAQARYYNSHGIQPEAVDNSTTAAKPRQVGVSHLGSTGSIPPNEQHYLGDSEIPVQSEVHEYEPIPLQKTKTTGSSKNKFKTMFDKVLQFSQENYGYQHKKEQGEQTPVTRNAEESFPAASISEGVTTAKPSSNEGVMTNPVVTDSPSPLQQQIDSTTASSNGQSQGNVPTSAVASTTRTRSPELQDNLKSSSSLLQDQTPQRQEDATDPTTSSTNELSAAEPTMVTSTHATKTIQAQTQDPPTKHKKSSFFTKLFKKKSSR
SIO_010081: YLR219W
subclass of: SO_0000673
so part of: YLR219W
location: 574151..576337
location: region:574151-576337:1
so has part: feature:574151-576337:1:exon

NP_013320.1
type: Protein
SIO_000068: ncbiprotein

S000004209
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574151-576337:1:exon

YLR220W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CCC1
locus tag: YLR220W
so part of: sequence
location: <576825..>577793
location: region:576825-577793:1
so has part: feature:576825-577793:1:exon
subclass of: SO_0000010

850917
type: Gene
SIO_000068: ncbigene

position:576825:1
position: 576825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:577793:1
position: 577793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:576825-577793:1:exon

YLR220W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CCC1
locus tag: YLR220W
product: Ccc1p
transcript id: NM_001182107.1
SIO_010081: YLR220W
subclass of: SO_0000673
so part of: YLR220W
location: <576825..>577793
location: region:576825-577793:1
so has part: feature:576825-577793:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:576825-577793:1:exon

YLR220W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CCC1
locus tag: YLR220W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:34203091]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11390404|PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8866476]
experiment: EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:11390404]
experiment: EXISTENCE:mutant phenotype:GO:0006826 iron ion transport [PMID:11390404]
experiment: EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:11390404]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:7941738]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:34203091|PMID:10713071]
experiment: EXISTENCE:mutant phenotype:GO:0015093 ferrous iron transmembrane transporter activity [PMID:11390404|PMID:34203091]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:8866476]
experiment: EXISTENCE:mutant phenotype:GO:1990461 detoxification of iron ion [PMID:34203091]
note: Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to vacuole decreases upon DNA replication stress; targeted to vacuole via AP-3 pathway
codon start: 1
product: Ccc1p
translation: MSIVALKNAVVTLIQKAKGSGGTSELGGSESTPLLRGSNSNSSRHDNLSSSSSDIIYGRNSAQDLENSPMSVGKDNRNGDNGSDNEKANLGFFQSVDPRVISDLIIGLSDGLTVPFALTAGLSSLGDAKLVITGGFAELISGAISMGLGGYLGAKSESDYYHAEVKKEKRKFYDNSNLINREIEDILLEINPNFSDETIVSFIKDLQRTPELMVDFIIRYGRGLDEPAENRELISAVTIGGGYLLGGLVPLVPYFFVSDVGTGLIYSIIVMVVTLFWFGYVKTKLSMGSGSSTSKKVTEGVEMVVVGGVAAGAAWFFVKLLG
SIO_010081: YLR220W
subclass of: SO_0000673
so part of: YLR220W
location: 576825..577793
location: region:576825-577793:1
so has part: feature:576825-577793:1:exon

NP_013321.1
type: Protein
SIO_000068: ncbiprotein

S000004210
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:576825-577793:1:exon

YLR221C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSA3
locus tag: YLR221C
so part of: sequence
location: complement(<578362..>579024)
location: region:578362-579024:-1
so has part: feature:578362-579024:-1:exon
subclass of: SO_0000010

850918
type: Gene
SIO_000068: ncbigene

position:578362:-1
position: 578362
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:579024:-1
position: 579024
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578362-579024:-1:exon

YLR221C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSA3
locus tag: YLR221C
product: Rsa3p
transcript id: NM_001182108.1
SIO_010081: YLR221C
subclass of: SO_0000673
so part of: YLR221C
location: complement(<578362..>579024)
location: region:578362-579024:-1
so has part: feature:578362-579024:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:578362-579024:-1:exon

YLR221C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSA3
locus tag: YLR221C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:15126390]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15126390]
note: Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
codon start: 1
product: Rsa3p
translation: MSAGDISAINIKSVKKNRRRKKRRTADVSSSDSSSSDPSSESEKEEIQNGAIEEHVGENGKSDHVFSKGNDEDKQEDIAIEVSDVELTDEESKDLKLNSKEVIDDLTKISLSKIPEPTKSQNKEGFMNASKIAENIKLAREEYNELAENFVPKGKDKTKLREEYLNLLFENYGDDINRLRAAPDFTNKSLSILADALQEGIGMFDIGELELVLKNKEMEN
SIO_010081: YLR221C
subclass of: SO_0000673
so part of: YLR221C
location: complement(578362..579024)
location: region:578362-579024:-1
so has part: feature:578362-579024:-1:exon

NP_013322.1
type: Protein
SIO_000068: ncbiprotein

S000004211
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578362-579024:-1:exon

YLR222C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP13
locus tag: YLR222C
so part of: sequence
location: complement(<579318..>581771)
location: region:579318-581771:-1
so has part: feature:579318-581771:-1:exon
subclass of: SO_0000010

850919
type: Gene
SIO_000068: ncbigene

position:579318:-1
position: 579318
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:581771:-1
position: 581771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579318-581771:-1:exon

YLR222C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP13
locus tag: YLR222C
product: Utp13p
transcript id: NM_001182109.1
SIO_010081: YLR222C
subclass of: SO_0000673
so part of: YLR222C
location: complement(<579318..>581771)
location: region:579318-581771:-1
so has part: feature:579318-581771:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579318-581771:-1:exon

YLR222C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP13
locus tag: YLR222C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
codon start: 1
product: Utp13p
translation: MDLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAKTHTIAQRTIRCILMHHNIAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDKLF
SIO_010081: YLR222C
subclass of: SO_0000673
so part of: YLR222C
location: complement(579318..581771)
location: region:579318-581771:-1
so has part: feature:579318-581771:-1:exon

NP_013323.1
type: Protein
SIO_000068: ncbiprotein

S000004212
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579318-581771:-1:exon

YLR223C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IFH1
locus tag: YLR223C
so part of: sequence
location: complement(<582233..>585490)
location: region:582233-585490:-1
so has part: feature:582233-585490:-1:exon
subclass of: SO_0000010

850920
type: Gene
SIO_000068: ncbigene

position:582233:-1
position: 582233
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:585490:-1
position: 585490
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:582233-585490:-1:exon

YLR223C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IFH1
locus tag: YLR223C
product: Ifh1p
transcript id: NM_001182110.1
SIO_010081: YLR223C
subclass of: SO_0000673
so part of: YLR223C
location: complement(<582233..>585490)
location: region:582233-585490:-1
so has part: feature:582233-585490:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:582233-585490:-1:exon

YLR223C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IFH1
locus tag: YLR223C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15620355]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15466158]
experiment: EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]
experiment: EXISTENCE:genetic interaction:GO:0003713 transcription coactivator activity [PMID:15620355]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15620355]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9755194]
experiment: EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15616569]
note: Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication
codon start: 1
product: Ifh1p
translation: MAGKKSPRKSTINHSTHSGKLPANIKRLIKKGESDTKSRQSPPTLSTTRPRRFSLIYSSESSLSDVSDSDKNKSTNPHKIKRKAKNISNNSQGKKSKLIQRQIDNDDEGTESSDYQAVTDGEESENEEEESEEEEEDDDEDDDDDDDDGSDSDSDSETSSDDENIDFVKLTAQRKKRAMKALSAMNTNSNTLYSSRENSNKNKSVKLSPKKENEEEQKEEKEKEKEEQQKQQESNKKEVNGSGTTTTQQALSFKFKKEDDGISFGNGNEGYNEDIGEEVLDLKNKENNGNEEDKLDSKVMLGNNDELRFPNISESDESEYDIDQDAYFDVINNEDSHGEIGTDLETGEDDLPILEEEEQNIVSELQNDDELSFDGSIHEEGSDPVEDAENKFLQNEYNQENGYDEEDDEEDEIMSDFDMPFYEDPKFANLYYYGDGSEPKLSLSTSLPLMLNDEKLSKLKKKEAKKREQEERKQRRKLYKKTQKPSTRTTSNVDNDEYIFNVFFQSDDENSGHKSKKGRHKSGKSHIEHKNKGSNLIKSNDDLEPSTHSTVLNSGKYDSSDDEYDNILLDVAHMPSDDECSESETSHDADTDEELRALDSDSLDIGTELDDDYEDDDDDSSVTNVFIDIDDLDPDSFYFHYDSDGSSSLISSNSDKENSDGSKDCKHDLLETVVYVDDESTDEDDNLPPPSSRSKNIGSKAKEIVSSNVVGLRPPKLGTWETDNKPFSIIDGLSTKSLYALIQEHQQLREQHQRAQTPDVKREGSSNGNNGDELTLNELLNMSELEDDSPSHTDDMENNYNDAINSKSTNGHAADWYEVPKVPLSAFRNKGINAYEEDEYMIPANSNRKVPIGYIGNERTRKKIDKMKELQRKKTEKKRQLKKKKKLLKIRKQRQKAIKEQETMNLQLGINGHEIIGNNNSHSDINTGTDFTTNENTPMNELPSHAPEDASLIPHNSDLAVDSNTRKNSTKSVGLDEIHEILGKDENDLLSVGDINGYDAQEGHVIEDTDADILASLTAPVQFDNTLSHENSNSMWRRRQSMVEAAAENLRFTKNGLFSESALADIEGIMGNDVNHSFEFNDVLQ
SIO_010081: YLR223C
subclass of: SO_0000673
so part of: YLR223C
location: complement(582233..585490)
location: region:582233-585490:-1
so has part: feature:582233-585490:-1:exon

NP_013324.1
type: Protein
SIO_000068: ncbiprotein

S000004213
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:582233-585490:-1:exon

YLR224W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UCC1
locus tag: YLR224W
so part of: sequence
location: <586464..>587573
location: region:586464-587573:1
so has part: feature:586464-587573:1:exon
subclass of: SO_0000010

850921
type: Gene
SIO_000068: ncbigene

position:586464:1
position: 586464
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:587573:1
position: 587573
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586464-587573:1:exon

YLR224W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UCC1
locus tag: YLR224W
product: Ucc1p
transcript id: NM_001182111.1
SIO_010081: YLR224W
subclass of: SO_0000673
so part of: YLR224W
location: <586464..>587573
location: region:586464-587573:1
so has part: feature:586464-587573:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:586464-587573:1:exon

YLR224W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UCC1
locus tag: YLR224W
experiment: EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]
experiment: EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:25982115]
experiment: EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:25982115]
experiment: EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]
experiment: EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]
note: F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds
codon start: 1
product: Ucc1p
translation: MNQSDSSLMDLPLEIHLSLLEYVPNELRAVNKYFYVLHNHSYKEKSLAWIAEDNYIWAVVKHSLCLYVKSLDPLRQHAREIIQETKEPGFNVPLCMTKYIADSWYIVYNALQYPGKIINMGWDKYTKSQDSNGSDSTSNFNSRPKERTLMQSLTALPVNFWSRRKDEPTPVNVWFYVKNAHVARYIPKIITEIGICNYGPKQIVASAGYINELITSEGIYCVNLGHLPRLYDEQIFEGTGTTHLPLELKAIDRTDSDVCINGDLVLLGYDFIPYQISKPWLLFRIEPVNSIEAIFNYSECSFSYQFAWSLACLQSEEKISFPRDTIIGHGLPYKPSKLIRIFVYKHPEQKQDLGQEIALPNWNTPYLRR
SIO_010081: YLR224W
subclass of: SO_0000673
so part of: YLR224W
location: 586464..587573
location: region:586464-587573:1
so has part: feature:586464-587573:1:exon

NP_013325.1
type: Protein
SIO_000068: ncbiprotein

S000004214
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586464-587573:1:exon

YLR225C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR225C
so part of: sequence
location: complement(<587695..>588918)
location: region:587695-588918:-1
so has part: feature:587695-588918:-1:exon
subclass of: SO_0000010

850922
type: Gene
SIO_000068: ncbigene

position:587695:-1
position: 587695
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:588918:-1
position: 588918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:587695-588918:-1:exon

YLR225C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR225C
product: uncharacterized protein
transcript id: NM_001182112.1
SIO_010081: YLR225C
subclass of: SO_0000673
so part of: YLR225C
location: complement(<587695..>588918)
location: region:587695-588918:-1
so has part: feature:587695-588918:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:587695-588918:-1:exon

YLR225C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR225C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MAVAIKKEKTKFAPVKEVLSEKDHANYTKFQDTSKLEWFCRTSNHKKFKSHSLLKAVRNPTETRIETQTLYFTDLTNGKCGLIQLLYSSVMGGIYKGFQLNFKIFKASSEENSEEDIDIWESFKIDNIKDFDTLKVESDNVTFHFVPLENSSSSGFAQLLIKIDIPKGSTSCLLKDLKVDITVNLQEGFIINPDGSNYYLDKSISLEELAKRDSSSTSRKMIRHVFVPRGFCNGTISYKKNDKPVKLDLKDTPMLYLDAVQGLIPNKAASKWNFLCFNGEKRSMMCIEFTTTKEYGSTTVTIWAVSDKDKILEVGSSVNDHAVKFPSTKEDKQNGWKYPTSISFPRGFEESNLRLVNRYDIMSELPAFIRSIAENLANMKPFIYQFCQKSKFDDDEGVSIIESTFIN
SIO_010081: YLR225C
subclass of: SO_0000673
so part of: YLR225C
location: complement(587695..588918)
location: region:587695-588918:-1
so has part: feature:587695-588918:-1:exon

NP_013326.1
type: Protein
SIO_000068: ncbiprotein

S000004215
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:587695-588918:-1:exon

YLR226W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CST4
gene: BUR2
locus tag: YLR226W
gene synonym: CST4
so part of: sequence
location: <589354..>590541
location: region:589354-590541:1
so has part: feature:589354-590541:1:exon
subclass of: SO_0000010

850923
type: Gene
SIO_000068: ncbigene

position:589354:1
position: 589354
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:590541:1
position: 590541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:589354-590541:1:exon

YLR226W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CST4
gene: BUR2
locus tag: YLR226W
gene synonym: CST4
product: Bur2p
transcript id: NM_001182113.1
SIO_010081: YLR226W
subclass of: SO_0000673
so part of: YLR226W
location: <589354..>590541
location: region:589354-590541:1
so has part: feature:589354-590541:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:589354-590541:1:exon

YLR226W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CST4
gene: BUR2
locus tag: YLR226W
gene synonym: CST4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:10982824]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:10982824]
experiment: EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:10982824]
experiment: EXISTENCE:mutant phenotype:GO:0033184 positive regulation of histone ubiquitination [PMID:16040246]
experiment: EXISTENCE:mutant phenotype:GO:0051571 positive regulation of histone H3-K4 methylation [PMID:16040246]
experiment: EXISTENCE:mutant phenotype:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:19328068]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:10982824]
note: Cyclin for the Sgv1p (Bur1p) protein kinase; subunit of the CDK-cyclin BUR kinase complex with Sgv1p (Bur1p); regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; involved in the recruitment of Spt6p to the CTD at the onset of transcription; regulates telomere elongation
codon start: 1
product: Bur2p
translation: MSATSSSGDVKKFQAVPKPTSNASPPPASSGFNARTLWPDLIETPENQWVFECKDIIEKIGTNGPIAVEIKKNMEKCLMYFYTLKKKLNLFDHTYTASCILFYRYWFIYGIPTAITECIHISQGILVTACKTMENNRPIEAYIKATCEFLMQNIPSLKSRTNIDKLKWEFRDKLVTNEKKILCLFGFDLNISNPKELIEEVFSGYYRFNRDHNLPENFKKAFPKILQESRNFMVQAVTQPVSLLCDGYTFIVLSLIYCGLEYKKLVDKDFRYPKNFFKDRFPIEVTPENFANIFTDYKLLEENFFNLKSNKGAKLQIDSSMIDSVIDESGDVENEVSEISDPFNYELIKSGEVKEEFLNHIETRVKDLLDKAKQESMKRKAKDPIRTPDAKKPKI
SIO_010081: YLR226W
subclass of: SO_0000673
so part of: YLR226W
location: 589354..590541
location: region:589354-590541:1
so has part: feature:589354-590541:1:exon

NP_013327.1
type: Protein
SIO_000068: ncbiprotein

S000004216
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:589354-590541:1:exon

YLR227C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADY4
locus tag: YLR227C
so part of: sequence
location: complement(<590562..>592043)
location: region:590562-592043:-1
so has part: feature:590562-592043:-1:exon
subclass of: SO_0000010

850924
type: Gene
SIO_000068: ncbigene

position:590562:-1
position: 590562
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592043:-1
position: 592043
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:590562-592043:-1:exon

YLR227C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADY4
locus tag: YLR227C
product: Ady4p
transcript id: NM_001182114.1
SIO_010081: YLR227C
subclass of: SO_0000673
so part of: YLR227C
location: complement(<590562..>592043)
location: region:590562-592043:-1
so has part: feature:590562-592043:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:590562-592043:-1:exon

YLR227C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADY4
locus tag: YLR227C
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:12796288]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0035974 meiotic spindle pole body [PMID:12796288]
note: Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
codon start: 1
product: Ady4p
translation: MNKDVDYQTFKKSLRKEFKKAVKTILNLQAYNGDLIRDFLALYIPYHVVFYNLSIMKKGSPLRIQTNNLLKEALAKILNFNLAMGPKHIIKIMKKDKADPETMNKLKLVLYIKLFQGVFGHVDKNYNLAFQSFRWCLQFIAYSKRTRLFASIADEQIGAFYELCELFISMLCCHCFLIDLKENEALVGNNLKNFIKRQNPNYSHGFDLNEETKSLQWHWSLDEVDVIEALYCVAFDAMDKITLKFSKVNENFVFSQFFQYCAEIEEMLAILRGKIWECECDVFGPRIGLLVDSNHMNETIQKNILSITFKLKNDPQIICCLNKILEGLLLSSGVQFKVIQFFYVLKLYYMQDNEYTFEASSEMDKLTIECLCIIENIIDACDNPDEVTDYQLPKVLLTAMEGKLLVAEKISEDNDCSESLDDYHPRTYQFRHPRIIIDKMKTKLKQKLRFDSPKDPETDDHWIEYWKYCYQDNIGNLPDILSRIYQTFTDPSN
SIO_010081: YLR227C
subclass of: SO_0000673
so part of: YLR227C
location: complement(590562..592043)
location: region:590562-592043:-1
so has part: feature:590562-592043:-1:exon

NP_013328.1
type: Protein
SIO_000068: ncbiprotein

S000004217
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:590562-592043:-1:exon

YNCL0032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0032C
so part of: sequence
location: complement(592519..592619)
location: region:592519-592619:-1
so has part: feature:592519-592619:-1:exon
subclass of: SO_0000663

850925
type: Gene
SIO_000068: ncbigene

position:592519:-1
position: 592519
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:592619:-1
position: 592619
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:592519-592619:-1:exon

YNCL0032C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0032C
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCL0032C
subclass of: SO_0000673
so part of: YNCL0032C
location: complement(join(592519..592562,592582..592619))
location: region:592519-592619:-1
so has part: feature:592582-592619:-1:exon
so has part: feature:592519-592562:-1:exon

S000006655
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:592582-592619:-1:exon

position:592582:-1
position: 592582
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:592519-592562:-1:exon

position:592562:-1
position: 592562
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(592706..593035)
location: region:592706-593035:-1
so has part: feature:592706-593035:-1:region

S000007070
type: SGD
SIO_000068: sgd

position:592706:-1
position: 592706
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:593035:-1
position: 593035
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:592706-593035:-1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YLRWTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YLRWTy1-2
so part of: sequence
location: 593145..599062
location: region:593145-599062:1
so has part: feature:593145-599062:1:region

S000007098
type: SGD
SIO_000068: sgd

position:593145:1
position: 593145
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:599062:1
position: 599062
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593145-599062:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 593145..593478
location: region:593145-593478:1
so has part: feature:593145-593478:1:region

S000007085
type: SGD
SIO_000068: sgd

position:593478:1
position: 593478
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593145-593478:1:region

YLR227W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR227W-B
so part of: sequence
location: <593438..>598706
location: region:593438-598706:1
so has part: feature:593438-598706:1:exon
subclass of: SO_0000010

850927
type: Gene
SIO_000068: ncbigene

position:593438:1
position: 593438
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:598706:1
position: 598706
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593438-598706:1:exon

YLR227W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR227W-B
product: gag-pol fusion protein
transcript id: NM_001184408.2
SIO_010081: YLR227W-B
subclass of: SO_0000673
so part of: YLR227W-B
location: <593438..>598706
location: region:593438-598706:1
so has part: feature:593438-598706:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593438-598706:1:exon

YLR227W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR227W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWVSKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSASQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKPISEINLRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSNNETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDPPPEPPTELSDSFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAAKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDTGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSHYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YLR227W-B
subclass of: SO_0000673
so part of: YLR227W-B
location: join(593438..594742,594744..598706)
location: region:593438-598706:1
so has part: feature:593438-594742:1:exon
so has part: feature:594744-598706:1:exon

NP_058171.1
type: Protein
SIO_000068: ncbiprotein

S000007376
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593438-594742:1:exon

position:594742:1
position: 594742
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:594744-598706:1:exon

position:594744:1
position: 594744
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR227W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR227W-A
so part of: sequence
location: <593438..>594760
location: region:593438-594760:1
so has part: feature:593438-594760:1:exon
subclass of: SO_0000010

850926
type: Gene
SIO_000068: ncbigene

position:594760:1
position: 594760
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593438-594760:1:exon

YLR227W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR227W-A
product: gag protein
transcript id: NM_001184407.1
SIO_010081: YLR227W-A
subclass of: SO_0000673
so part of: YLR227W-A
location: <593438..>594760
location: region:593438-594760:1
so has part: feature:593438-594760:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593438-594760:1:exon

YLR227W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR227W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YLR227W-A
subclass of: SO_0000673
so part of: YLR227W-A
location: 593438..594760
location: region:593438-594760:1
so has part: feature:593438-594760:1:exon

NP_058172.1
type: Protein
SIO_000068: ncbiprotein

S000007375
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593438-594760:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 598729..599062
location: region:598729-599062:1
so has part: feature:598729-599062:1:region

S000007086
type: SGD
SIO_000068: sgd

position:598729:1
position: 598729
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:598729-599062:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 599268..599544
location: region:599268-599544:1
so has part: feature:599268-599544:1:region

S000007087
type: SGD
SIO_000068: sgd

position:599268:1
position: 599268
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:599544:1
position: 599544
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599268-599544:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(599570..599844)
location: region:599570-599844:-1
so has part: feature:599570-599844:-1:region

S000007080
type: SGD
SIO_000068: sgd

position:599570:-1
position: 599570
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:599844:-1
position: 599844
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599570-599844:-1:region

YLR228C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM22
locus tag: YLR228C
so part of: sequence
location: complement(<600019..>602463)
location: region:600019-602463:-1
so has part: feature:600019-602463:-1:exon
subclass of: SO_0000010

850928
type: Gene
SIO_000068: ncbigene

position:600019:-1
position: 600019
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:602463:-1
position: 602463
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:600019-602463:-1:exon

YLR228C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM22
locus tag: YLR228C
product: Ecm22p
transcript id: NM_001182115.1
SIO_010081: YLR228C
subclass of: SO_0000673
so part of: YLR228C
location: complement(<600019..>602463)
location: region:600019-602463:-1
so has part: feature:600019-602463:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:600019-602463:-1:exon

YLR228C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM22
locus tag: YLR228C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11533229]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11533229]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11533229]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:18675371]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:18675371]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11208779|PMID:26448198]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16055745]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11533229|PMID:16055745|PMID:26448198]
note: Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
codon start: 1
product: Ecm22p
translation: MTSDDGNAGQEREKDAELIEVGGKKVSKTSTGKRKFHNKSKTGCDNCKRRRVKCDEGKPFCKKCTNMKLDCVYSPIQPRRRKDSSSSKFASAVHDRVGKKNLSDNAIMLQQQQQQLHHQQEQQFRQQQQVQLQQQLLPHVGTDEQSNSPNSVPPSVSNNMENLLLPHLLASLVNNTSNSTNSSANGAEAHNNITQTAPSSMINNNHPNMALPGNSPLSIPITPSFQSTAMNLSSSLNGLLSPGRLNSVTNGLQQPQLQQQNQQIPQQQGTQSPFSNIPFDQLAQLNKMGLNFNMKSFNTLFPYGAANGMASEFQELFGLGKFATSNNRAIKVSTAEEALANMQQEQEDKNKQFTKNPLDNTKTDAVNSGNNPLNGNENKVTASDILSHNKNLIIDNTGLTISPPHTLSKPSIDQNIASPSTGVSNVTSTKSLLSIPDNRTALGNSPTLKTSPMGDLLSNSEALSPRSSNSHTQQQSSPHSNASSASRLVPELVGLSRKSNLNLIDLKLFHHYCTDVWHTITEAGISGPEVWSTYIPDLAFHFPFLMHTILAFSATHLSRTEAGLDNYVSSHRLEALRLLREAVLEISDDNTDALVASALILILDSLANASSSSPTAWIFHVKGAVTILTAVWPLSETSKFYNLISVDLSDLGEAVINQSNHNNDNDNSNNGDGNNNNTISELVCFDESIADLYPVEIDSPYLITLAYLDKLHREKNQLDFMLRVFSFPALLDRTFLALLMTGDLGAMRIMRSYYTLLRGYTTEIKDKVWFLDSVSQVLPQDVDEYSGGGGMHMMLDFLGGGLPSMTTTNFSAFM
SIO_010081: YLR228C
subclass of: SO_0000673
so part of: YLR228C
location: complement(600019..602463)
location: region:600019-602463:-1
so has part: feature:600019-602463:-1:exon

NP_013329.1
type: Protein
SIO_000068: ncbiprotein

S000004218
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:600019-602463:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1218; Autonomously Replicating Sequence
so part of: sequence
location: 603024..603132
location: region:603024-603132:1
so has part: feature:603024-603132:1:region

S000118477
type: SGD
SIO_000068: sgd

position:603024:1
position: 603024
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:603132:1
position: 603132
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:603024-603132:1:region

YLR229C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC42
locus tag: YLR229C
so part of: sequence
location: complement(<604212..>604787)
location: region:604212-604787:-1
so has part: feature:604212-604787:-1:exon
subclass of: SO_0000010

850930
type: Gene
SIO_000068: ncbigene

position:604212:-1
position: 604212
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:604787:-1
position: 604787
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:604212-604787:-1:exon

YLR229C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC42
locus tag: YLR229C
product: Rho family GTPase CDC42
transcript id: NM_001182116.1
SIO_010081: YLR229C
subclass of: SO_0000673
so part of: YLR229C
location: complement(<604212..>604787)
location: region:604212-604787:-1
so has part: feature:604212-604787:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:604212-604787:-1:exon

YLR229C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC42
locus tag: YLR229C
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12455994|PMID:8167411]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12455994|PMID:11598008|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11591390]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:32556066]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12455994|PMID:8167411]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12455994|PMID:8167411]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12455994]
experiment: EXISTENCE:direct assay:GO:0005940 septin ring [PMID:23906065]
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:12455994]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:22832273|PMID:8167411]
experiment: EXISTENCE:direct assay:GO:0071763 nuclear membrane organization [PMID:32556066]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:19955214]
experiment: EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:22323294]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:11003652]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10066831]
experiment: EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10066831]
experiment: EXISTENCE:mutant phenotype:GO:0007119 budding cell isotropic bud growth [PMID:10066831]
experiment: EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:1904541]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:23468594]
experiment: EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:14517318|PMID:16371506]
experiment: EXISTENCE:mutant phenotype:GO:0031384 regulation of initiation of mating projection growth [PMID:14734532]
experiment: EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]
experiment: EXISTENCE:mutant phenotype:GO:0045921 positive regulation of exocytosis [PMID:11595741]
experiment: EXISTENCE:mutant phenotype:GO:0060178 regulation of exocyst localization [PMID:11595741]
experiment: EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:8643578]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9367980|PMID:9367979]
experiment: EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:19955214]
note: Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant
codon start: 1
product: Rho family GTPase CDC42
translation: MQTLKCVVVGDGAVGKTCLLISYTTNQFPADYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPSTDVFLVCFSVISPPSFENVKEKWFPEVHHHCPGVPCLVVGTQIDLRDDKVIIEKLQRQRLRPITSEQGSRLARELKAVKYVECSALTQRGLKNVFDEAIVAALEPPVIKKSKKCAIL
SIO_010081: YLR229C
subclass of: SO_0000673
so part of: YLR229C
location: complement(604212..604787)
location: region:604212-604787:-1
so has part: feature:604212-604787:-1:exon

NP_013330.1
type: Protein
SIO_000068: ncbiprotein

S000004219
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:604212-604787:-1:exon

YNCL0033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0033C
so part of: sequence
location: complement(605300..605432)
location: region:605300-605432:-1
so has part: feature:605300-605432:-1:exon
subclass of: SO_0000663

850931
type: Gene
SIO_000068: ncbigene

position:605300:-1
position: 605300
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:605432:-1
position: 605432
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605300-605432:-1:exon

YNCL0033C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0033C
product: tRNA-Ile
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis
SIO_010081: YNCL0033C
subclass of: SO_0000673
so part of: YNCL0033C
location: complement(join(605300..605335,605396..605432))
location: region:605300-605432:-1
so has part: feature:605396-605432:-1:exon
so has part: feature:605300-605335:-1:exon

S000006614
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605396-605432:-1:exon

position:605396:-1
position: 605396
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:605300-605335:-1:exon

position:605335:-1
position: 605335
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YLR231C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BNA5
locus tag: YLR231C
so part of: sequence
location: complement(<605758..>607119)
location: region:605758-607119:-1
so has part: feature:605758-607119:-1:exon
subclass of: SO_0000010

850933
type: Gene
SIO_000068: ncbigene

position:605758:-1
position: 605758
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:607119:-1
position: 607119
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605758-607119:-1:exon

YLR231C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BNA5
locus tag: YLR231C
product: kynureninase
transcript id: NM_001182118.1
SIO_010081: YLR231C
subclass of: SO_0000673
so part of: YLR231C
location: complement(<605758..>607119)
location: region:605758-607119:-1
so has part: feature:605758-607119:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:605758-607119:-1:exon

YLR231C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BNA5
locus tag: YLR231C
EC number: 3.7.1.3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD biosynthetic process from tryptophan [PMID:12062417]
experiment: EXISTENCE:mutant phenotype:GO:0030429 kynureninase activity [PMID:12062417]
note: Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
codon start: 1
product: kynureninase
translation: MEKALELDGEYPESLRDEFNIPTFKSMGLSSDDKPVTYLCGNSLGLMPKSTRNSINAELDAWSDCAVESHFKHPEEARGKVPWVSIDLPILPLLAPIVGAQENEVAVMNSLTANLNSLLITFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIHGISEPENVFIQIEPREGETYIRTQDILDTIEVNQDELALVCLSGVQYYTGQYFDIGRITSFAHQFPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGGLFVHSKHTKPDPAKESLPRLAGWWGNDPAKRFQMLEVFEPIPGALGFRQSNPSVIDTVALRSSLELFAKFNGINEVRKRSLLLTNYMTELLEASKYYKHPLRIEKLPCFFTILTPTSTDEEHGAQLSLYFDSDTGKEDIMPKVFQYLHDHGVIGDARRPNVIRLAPAPLYNTFSDVYIAVNALNEAMDKL
SIO_010081: YLR231C
subclass of: SO_0000673
so part of: YLR231C
location: complement(605758..607119)
location: region:605758-607119:-1
so has part: feature:605758-607119:-1:exon

NP_013332.1
type: Protein
SIO_000068: ncbiprotein

S000004221
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605758-607119:-1:exon

YLR233C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EST1
locus tag: YLR233C
so part of: sequence
location: complement(<607425..>609524)
location: region:607425-609524:-1
so has part: feature:607425-609524:-1:exon
subclass of: SO_0000010

850934
type: Gene
SIO_000068: ncbigene

position:607425:-1
position: 607425
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:609524:-1
position: 609524
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:607425-609524:-1:exon

YLR233C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EST1
locus tag: YLR233C
product: Est1p
transcript id: NM_001182120.1
SIO_010081: YLR233C
subclass of: SO_0000673
so part of: YLR233C
location: complement(<607425..>609524)
location: region:607425-609524:-1
so has part: feature:607425-609524:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:607425-609524:-1:exon

YLR233C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EST1
locus tag: YLR233C
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8985179]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101098]
experiment: EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:10898986]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12101098]
experiment: EXISTENCE:direct assay:GO:0007004 telomere maintenance via telomerase [PMID:10898986]
experiment: EXISTENCE:direct assay:GO:0032210 regulation of telomere maintenance via telomerase [PMID:27659693]
experiment: EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]
experiment: EXISTENCE:direct assay:GO:0071919 G-quadruplex DNA formation [PMID:20098422|PMID:23376615]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:2655926]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:10898986|PMID:8978029]
experiment: EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:12414733]
note: TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication
codon start: 1
product: Est1p
translation: MDNEEVNEECMRLFFKNARAHLDKHLTSRLTCDENAYITFRCFLDGIHRKSTRFLEELLLKQENMYHNNNYERINDSVIPLVLKLLWLQIHEPTLQWFEHWFHDIMRLSNRRKFRVFRIFQKKMIQFFKITHRYYYDIIEHLCAKYDMNSVISNALFAKLNLMQYTDGLSTHEKIILNTSNPLTFSIVISLQRCVINLGSTHFYKTLLNKPSNKPKSVEGFEKSIRYLNIASLYLPAVGDTYFQRAKIYLITGKFSLYFFELVRGALVRIPSKCALNNLKDFILTPDFPERRRLMKKLAILVSKDLKGEKSFFEGQIVLQFLSIVEHTLVPQSWNASRASNCWLLKEHLQMAALKYHSGNINVILENLAATMGSFDLMFTTRKSKEQKNKLKYADLSERQVFFLDLSFDFIANIIDVVIKPSWQKNMEDFRYLAIIRLLMCWIKSYRSILQYTHRHRKFCTSFALLLNDLINSPLNCSGNIYSHRPKRSYLFREDIIFREFSCINFALTDFNDDYVYDSPDMINNIIGCPTLTKVLSPKEECVLRIRSIIFSGMKFLEKNDTGVIWNASKYKFDLISPNIKIKRQIALSEISSKINVKTQQERVVSSRKVEAKRDEQQRKRAGKIAVTELEKQFANVRRTKKLSPLPEKDGVSSELVKHAASRGRKTITGPLSSDFLSYPDEAIDADEDITVQVPDTPT
SIO_010081: YLR233C
subclass of: SO_0000673
so part of: YLR233C
location: complement(607425..609524)
location: region:607425-609524:-1
so has part: feature:607425-609524:-1:exon

NP_013334.1
type: Protein
SIO_000068: ncbiprotein

S000004223
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:607425-609524:-1:exon

YLR234W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EDR1
gene: TOP3
locus tag: YLR234W
gene synonym: EDR1
so part of: sequence
location: <609783..>611753
location: region:609783-611753:1
so has part: feature:609783-611753:1:exon
subclass of: SO_0000010

850935
type: Gene
SIO_000068: ncbigene

position:609783:1
position: 609783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611753:1
position: 611753
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:609783-611753:1:exon

YLR234W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EDR1
gene: TOP3
locus tag: YLR234W
gene synonym: EDR1
product: DNA topoisomerase 3
transcript id: NM_001182121.1
SIO_010081: YLR234W
subclass of: SO_0000673
so part of: YLR234W
location: <609783..>611753
location: region:609783-611753:1
so has part: feature:609783-611753:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:609783-611753:1:exon

YLR234W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EDR1
gene: TOP3
locus tag: YLR234W
gene synonym: EDR1
EC number: 5.6.2.1
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:1324925]
experiment: EXISTENCE:direct assay:GO:0003916 DNA topoisomerase activity [PMID:22885009]
experiment: EXISTENCE:direct assay:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:1324925]
experiment: EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]
experiment: EXISTENCE:direct assay:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15899853]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:16546998]
experiment: EXISTENCE:mutant phenotype:GO:0000018 regulation of DNA recombination [PMID:1328869]
experiment: EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:7708702]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:17571075]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:1328869]
experiment: EXISTENCE:physical interaction:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15889139]
note: DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination
codon start: 1
product: DNA topoisomerase 3
translation: MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGEYIGWEIWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVGTRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAGNVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVYDRVKASM
SIO_010081: YLR234W
subclass of: SO_0000673
so part of: YLR234W
location: 609783..611753
location: region:609783-611753:1
so has part: feature:609783-611753:1:exon

NP_013335.1
type: Protein
SIO_000068: ncbiprotein

S000004224
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:609783-611753:1:exon

YLR236C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR236C
so part of: sequence
location: complement(<611794..>612117)
location: region:611794-612117:-1
so has part: feature:611794-612117:-1:exon
subclass of: SO_0000010

850937
type: Gene
SIO_000068: ncbigene

position:611794:-1
position: 611794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:612117:-1
position: 612117
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611794-612117:-1:exon

YLR236C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR236C
product: uncharacterized protein
transcript id: NM_001348857.1
SIO_010081: YLR236C
subclass of: SO_0000673
so part of: YLR236C
location: complement(<611794..>612117)
location: region:611794-612117:-1
so has part: feature:611794-612117:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611794-612117:-1:exon

YLR236C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR236C
note: hypothetical protein; conserved across S. cerevisiae strains; overlaps ORF YLR235C
codon start: 1
product: uncharacterized protein
translation: MHTICLRSPIDESSPLPYKSIRQPLENAHSCQALCSLMAVLCASAAHRLSETFPMRLVVAREYANWGAFQHAFTRRAGASVAATSAWFDAVAAGTENAHMQSAESCN
SIO_010081: YLR236C
subclass of: SO_0000673
so part of: YLR236C
location: complement(611794..612117)
location: region:611794-612117:-1
so has part: feature:611794-612117:-1:exon

NP_001335797.1
type: Protein
SIO_000068: ncbiprotein

S000004226
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611794-612117:-1:exon

YLR237W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: THI10
gene: THI7
locus tag: YLR237W
gene synonym: THI10
so part of: sequence
location: <612367..>614163
location: region:612367-614163:1
so has part: feature:612367-614163:1:exon
subclass of: SO_0000010

850938
type: Gene
SIO_000068: ncbigene

position:612367:1
position: 612367
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:614163:1
position: 614163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:612367-614163:1:exon

YLR237W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: THI10
gene: THI7
locus tag: YLR237W
gene synonym: THI10
product: thiamine transporter THI7
transcript id: NM_001182124.1
SIO_010081: YLR237W
subclass of: SO_0000673
so part of: YLR237W
location: <612367..>614163
location: region:612367-614163:1
so has part: feature:612367-614163:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:612367-614163:1:exon

YLR237W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: THI10
gene: THI7
locus tag: YLR237W
gene synonym: THI10
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16850348|PMID:9235906]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0015234 thiamine transmembrane transporter activity [PMID:9358046]
experiment: EXISTENCE:genetic interaction:GO:0015888 thiamine transport [PMID:16850348|PMID:9358046]
experiment: EXISTENCE:genetic interaction:GO:1903088 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport [PMID:24778186]
experiment: EXISTENCE:genetic interaction:GO:1903089 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity [PMID:24778186]
experiment: EXISTENCE:mutant phenotype:GO:0015234 thiamine transmembrane transporter activity [PMID:9235906|PMID:9358046]
experiment: EXISTENCE:mutant phenotype:GO:0015888 thiamine transport [PMID:16850348|PMID:9235906|PMID:9358046]
note: Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
codon start: 1
product: thiamine transporter THI7
translation: MSFGSKVSRALRFLEIPVKDRASVSFLKNPDLQPIKSANQTWGFWSNFAYWGVMSFSVGTWMSASSALGVGLSYPETIGTFIVGDVLTIIFTLANSCPGYDWKVGFTLAQRFVFGIYGSAFGIIIRILMSIVNYGSNAWVGGLCINMILDSWSHHYLHLPNTLSSKVAMTTKELIGFIIFHVLTAFCYLMKPYHMNYILIWSCVATFFSMLGMVIYLAKQAHGVGELFTSTKSTATGSTKAWAWVYMISYWFGSVSPGSTNQSDYSRFGSSNWAIWAGTICALLIPTTLIPVFGVIGASTCDKLYGEQYWMPMDIFNHWLTTNYSAGARAGAFFCGLSFVLSQMSYTISNCGFASGMDLAGLLPKYVDIKRGALFAACVSWACLPWNFYNSSSTFLTVMSSFGVVMTPIISVMICDNFLIRKRQYSITNAFILKGEYYFTKGVNWRAIVAWVCGMTPGLPGIAWEVNNDYFHNTGIVNFFYGDSFFSFLISFFVYWGLCLLFPFKITVKHDDKDYYGAFTDEEARKKGMVPYSEISEEEIRAYTLGEGYTTGHEYRPEGSDDEIPELVKTSSENTNEFEIVHHKNNEKQSSTASEKAA
SIO_010081: YLR237W
subclass of: SO_0000673
so part of: YLR237W
location: 612367..614163
location: region:612367-614163:1
so has part: feature:612367-614163:1:exon

NP_013338.1
type: Protein
SIO_000068: ncbiprotein

S000004227
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:612367-614163:1:exon

YLR238W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAR10
locus tag: YLR238W
so part of: sequence
location: <614755..>616191
location: region:614755-616191:1
so has part: feature:614755-616191:1:exon
subclass of: SO_0000010

850939
type: Gene
SIO_000068: ncbigene

position:614755:1
position: 614755
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:616191:1
position: 616191
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:614755-616191:1:exon

YLR238W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAR10
locus tag: YLR238W
product: Far10p
transcript id: NM_001182125.1
SIO_010081: YLR238W
subclass of: SO_0000673
so part of: YLR238W
location: <614755..>616191
location: region:614755-616191:1
so has part: feature:614755-616191:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:614755-616191:1:exon

YLR238W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAR10
locus tag: YLR238W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12514182|PMID:23625923]
experiment: EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]
note: Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication
codon start: 1
product: Far10p
translation: MTGPGPEINKEEHPSSPGKKQITYNSIPKNANLIDGSTNSSKRPIEKYDKRIADPTKSYFPHSISRTPRRKYTYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLRGGKRVDSHTFSQVRSDNGNFDSRVLSRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEELFVQPLLESPIFENEDSDDCHTITEKEEAAAITSHIYGDSNNLELEEVILGSDTEILSGIFINNCIGTSPTLSNIIKTLAMEIPFSKCDNFKLQSMENFLINYTTHLEYTNKLLVEKNDQQLVKLQNGLRRKLSGKYEKIIEQNRNQVKQLERDHMFFKKSFEVKKRRNNEKQKSMEREIEDLKTRLEVERYKNSQMMKKNKQKEQELSTASKKKTTEHDTRGVPGMNPKGTDKFSIKNTLCNHFTLLTFGTISIGIIAIVFKILSPN
SIO_010081: YLR238W
subclass of: SO_0000673
so part of: YLR238W
location: 614755..616191
location: region:614755-616191:1
so has part: feature:614755-616191:1:exon

NP_013339.1
type: Protein
SIO_000068: ncbiprotein

S000004228
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:614755-616191:1:exon

YLR239C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LIP2
locus tag: YLR239C
so part of: sequence
location: complement(<616332..>617318)
location: region:616332-617318:-1
so has part: feature:616332-617318:-1:exon
subclass of: SO_0000010

850940
type: Gene
SIO_000068: ncbigene

position:616332:-1
position: 616332
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:617318:-1
position: 617318
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616332-617318:-1:exon

YLR239C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LIP2
locus tag: YLR239C
product: lipoyl(octanoyl) transferase LIP2
transcript id: NM_001182126.1
SIO_010081: YLR239C
subclass of: SO_0000673
so part of: YLR239C
location: complement(<616332..>617318)
location: region:616332-617318:-1
so has part: feature:616332-617318:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:616332-617318:-1:exon

YLR239C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LIP2
locus tag: YLR239C
EC number: 2.3.1.181
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:11356580|PMID:19570983]
experiment: EXISTENCE:mutant phenotype:GO:0016874 ligase activity [PMID:11356580]
note: Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
codon start: 1
product: lipoyl(octanoyl) transferase LIP2
translation: MSRCIRQSVCTNFNVCRRQCFSTYASALKEMTHPIKPSAQTLRHLQFTQRIPFQKGLEIQETLVRANLDIKDIQSKIERKLIQLDEEYKGTATINDNEKRILDKVMAMKPNPIILTFEFEPTYTGGKRIKKTMTPDQIAAYESFIPETQKDNPRPKFVQVERGGQVTFHGPGQIVIYIILDLKTFQSFPAKCLVSCIEQATIRTLKNTKMCDDTDKPLNLDAMTTKDTGVWVENGKKKVASVGIHVRRSITSHGVAINVNTDLSYMNSFEMCGLKNTLTTSIMEQRPDAVVNVQSVAISFVKEMTKLLGIKTLERMQIDDVNILKKNP
SIO_010081: YLR239C
subclass of: SO_0000673
so part of: YLR239C
location: complement(616332..617318)
location: region:616332-617318:-1
so has part: feature:616332-617318:-1:exon

NP_013340.1
type: Protein
SIO_000068: ncbiprotein

S000004229
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:616332-617318:-1:exon

YLR240W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: END12
alternative label: PEP15
alternative label: STT8
alternative label: VPL7
alternative label: VPS7
alternative label: VPT29
gene: VPS34
locus tag: YLR240W
gene synonym: END12; PEP15; STT8; VPL7; VPS7; VPT29
so part of: sequence
location: <617533..>620160
location: region:617533-620160:1
so has part: feature:617533-620160:1:exon
subclass of: SO_0000010

850941
type: Gene
SIO_000068: ncbigene

position:617533:1
position: 617533
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:620160:1
position: 620160
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:617533-620160:1:exon

YLR240W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: END12
alternative label: PEP15
alternative label: STT8
alternative label: VPL7
alternative label: VPS7
alternative label: VPT29
gene: VPS34
locus tag: YLR240W
gene synonym: END12; PEP15; STT8; VPL7; VPS7; VPT29
product: phosphatidylinositol 3-kinase VPS34
transcript id: NM_001182127.1
SIO_010081: YLR240W
subclass of: SO_0000673
so part of: YLR240W
location: <617533..>620160
location: region:617533-620160:1
so has part: feature:617533-620160:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:617533-620160:1:exon

YLR240W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: END12
alternative label: PEP15
alternative label: STT8
alternative label: VPL7
alternative label: VPS7
alternative label: VPT29
gene: VPS34
locus tag: YLR240W
gene synonym: END12; PEP15; STT8; VPL7; VPS7; VPT29
EC number: 2.7.1.137
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16421251|PMID:19001347]
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:16421251]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:7989323]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:16421251]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:21121900]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016303 1-phosphatidylinositol-3-kinase activity [PMID:8385367|PMID:7989323]
experiment: EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]
experiment: EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]
experiment: EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8385367|PMID:7989323]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:23335340]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:18586673]
experiment: EXISTENCE:mutant phenotype:GO:0016303 1-phosphatidylinositol-3-kinase activity [PMID:8385367]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:21121900]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:23335340]
experiment: EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8385367]
experiment: EXISTENCE:mutant phenotype:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:18586673]
note: Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
codon start: 1
product: phosphatidylinositol 3-kinase VPS34
translation: MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT
SIO_010081: YLR240W
subclass of: SO_0000673
so part of: YLR240W
location: 617533..620160
location: region:617533-620160:1
so has part: feature:617533-620160:1:exon

NP_013341.1
type: Protein
SIO_000068: ncbiprotein

S000004230
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:617533-620160:1:exon

YLR241W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CSC1
locus tag: YLR241W
so part of: sequence
location: <620473..>622821
location: region:620473-622821:1
so has part: feature:620473-622821:1:exon
subclass of: SO_0000010

850942
type: Gene
SIO_000068: ncbigene

position:620473:1
position: 620473
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:622821:1
position: 622821
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:620473-622821:1:exon

YLR241W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CSC1
locus tag: YLR241W
product: Csc1p
transcript id: NM_001182128.1
SIO_010081: YLR241W
subclass of: SO_0000673
so part of: YLR241W
location: <620473..>622821
location: region:620473-622821:1
so has part: feature:620473-622821:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:620473-622821:1:exon

YLR241W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CSC1
locus tag: YLR241W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]
experiment: EXISTENCE:direct assay:GO:0005227 calcium activated cation channel activity [PMID:24503647]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006812 cation transport [PMID:24503647]
note: Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1
codon start: 1
product: Csc1p
translation: MTSYIERLKSAASYLDTVPDEHHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQSSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKIDDGNDDDDSESSLIHLVKRIVEGSGDGDNHSAPERTNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEALKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQPYSENYHLLGNEQSGAVTHGENVPSSNNNDEDTILYSQISLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPTAFVTMDSVANAQMAAQAVLDPRVHYFITRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIGFPLVKIKAKTPRQRNELYNPPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGTLAGFEGGWVLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSSIREYERDNSTVNSANEEESYAYPYAVSELEGPMLD
SIO_010081: YLR241W
subclass of: SO_0000673
so part of: YLR241W
location: 620473..622821
location: region:620473-622821:1
so has part: feature:620473-622821:1:exon

NP_013342.1
type: Protein
SIO_000068: ncbiprotein

S000004231
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:620473-622821:1:exon

YLR242C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARV1
locus tag: YLR242C
so part of: sequence
location: complement(<622918..>623883)
location: region:622918-623883:-1
so has part: feature:622918-623883:-1:exon
subclass of: SO_0000010

850943
type: Gene
SIO_000068: ncbigene

position:622918:-1
position: 622918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:623883:-1
position: 623883
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:622918-623883:-1:exon

YLR242C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARV1
locus tag: YLR242C
product: sterol homeostasis protein ARV1
transcript id: NM_001182129.1
SIO_010081: YLR242C
subclass of: SO_0000673
so part of: YLR242C
location: complement(<622918..>623883)
location: region:622918-623883:-1
so has part: feature:622918-623883:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:622918-623883:-1:exon

YLR242C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARV1
locus tag: YLR242C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12145310|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12145310]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:23668914]
experiment: EXISTENCE:genetic interaction:GO:0035376 sterol import [PMID:11063737]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:18287539]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15173322]
experiment: EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:18287539]
experiment: EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:15173322]
experiment: EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:11063737]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:18287539]
experiment: EXISTENCE:mutant phenotype:GO:0097036 regulation of plasma membrane sterol distribution [PMID:23668914]
note: Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null
codon start: 1
product: sterol homeostasis protein ARV1
translation: MICITCMRPVDSLYTVYSNDHIQLTDCPYCQETVDKYVEIDNVLLFIDLLLLKAGAYRHLVFNALELHLSKYPKRKALNDCQCLRDYTQALLFNVKNWFCKYDRLNRLWLLLLSFEIYLTWVTEESKYIYYLNRNNNDGKLIMLSKKLPESFKWDSAIMRNTITSKVFTWSPPIQYLYFASYCILDVSLFHTFTQYFILKKLHWKHYSVSSKDVISYTILLSYGAKIFPILMLIWPYDTLISMSIIKWVANLYIIESLKIVTNLSYWNIIKIFISVSLLRYFMVKPILIVFVAKFNFSVIKNLIHQEFILLLQKSGTYLLL
SIO_010081: YLR242C
subclass of: SO_0000673
so part of: YLR242C
location: complement(622918..623883)
location: region:622918-623883:-1
so has part: feature:622918-623883:-1:exon

NP_013343.1
type: Protein
SIO_000068: ncbiprotein

S000004232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:622918-623883:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1219; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay
so part of: sequence
location: 623198..623861
location: region:623198-623861:1
so has part: feature:623198-623861:1:region

S000130183
type: SGD
SIO_000068: sgd

position:623198:1
position: 623198
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:623861:1
position: 623861
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:623198-623861:1:region

YLR243W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPN3
locus tag: YLR243W
so part of: sequence
location: <624203..>625021
location: region:624203-625021:1
so has part: feature:624203-625021:1:exon
subclass of: SO_0000010

850944
type: Gene
SIO_000068: ncbigene

position:624203:1
position: 624203
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:625021:1
position: 625021
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:624203-625021:1:exon

YLR243W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPN3
locus tag: YLR243W
product: putative signal sequence-binding GTPase GPN3
transcript id: NM_001182130.1
SIO_010081: YLR243W
subclass of: SO_0000673
so part of: YLR243W
location: <624203..>625021
location: region:624203-625021:1
so has part: feature:624203-625021:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:624203-625021:1:exon

YLR243W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPN3
locus tag: YLR243W
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:23267056]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:23324351]
note: Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
codon start: 1
product: putative signal sequence-binding GTPase GPN3
translation: MSRVGVMVLGPAGAGKSTFCNSIISHMQTVGRRAHIVNLDPAAEATKYEFTIDIRDLISLDDVMEEMDLGPNGALIYCFEYLLKNLDWLDEEIGDFNDEYLIFDCPGQIELYTHIPVLPNIVRHLTQQLNFNLCATYLLEAPFVIDSSKFFSGALSAMSAMILLELPHINVLSKLDLIKGDINKKKLKRFLNPDAMLLMETEGMNQASNPKFLRLNQCIANLVDDFGMVQFLPLESNNPDSIETILSYVDDITQWAEGQEQKEPNDQIDVEE
SIO_010081: YLR243W
subclass of: SO_0000673
so part of: YLR243W
location: 624203..625021
location: region:624203-625021:1
so has part: feature:624203-625021:1:exon

NP_013344.1
type: Protein
SIO_000068: ncbiprotein

S000004233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:624203-625021:1:exon

YLR244C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAP1
locus tag: YLR244C
so part of: sequence
location: complement(<625168..>626331)
location: region:625168-626331:-1
so has part: feature:625168-626331:-1:exon
subclass of: SO_0000010

850945
type: Gene
SIO_000068: ncbigene

position:625168:-1
position: 625168
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:626331:-1
position: 626331
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:625168-626331:-1:exon

YLR244C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAP1
locus tag: YLR244C
product: methionine aminopeptidase MAP1
transcript id: NM_001182131.1
SIO_010081: YLR244C
subclass of: SO_0000673
so part of: YLR244C
location: complement(<625168..>626331)
location: region:625168-626331:-1
so has part: feature:625168-626331:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:625168-626331:-1:exon

YLR244C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAP1
locus tag: YLR244C
EC number: 3.4.11.18
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:11968008]
experiment: EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:2246265]
experiment: EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:21124907]
experiment: EXISTENCE:mutant phenotype:GO:0035551 protein initiator methionine removal involved in protein maturation [PMID:11811952]
note: Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain
codon start: 1
product: methionine aminopeptidase MAP1
translation: MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYKAHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQRNDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYPSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGENISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHTLLVTEHGVEILTARNKKSPGGPRQRIK
SIO_010081: YLR244C
subclass of: SO_0000673
so part of: YLR244C
location: complement(625168..626331)
location: region:625168-626331:-1
so has part: feature:625168-626331:-1:exon

NP_013345.1
type: Protein
SIO_000068: ncbiprotein

S000004234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:625168-626331:-1:exon

YLR245C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDD1
locus tag: YLR245C
so part of: sequence
location: complement(<626502..>626930)
location: region:626502-626930:-1
so has part: feature:626502-626930:-1:exon
subclass of: SO_0000010

850946
type: Gene
SIO_000068: ncbigene

position:626502:-1
position: 626502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:626930:-1
position: 626930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:626502-626930:-1:exon

YLR245C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDD1
locus tag: YLR245C
product: cytidine deaminase
transcript id: NM_001182132.1
SIO_010081: YLR245C
subclass of: SO_0000673
so part of: YLR245C
location: complement(<626502..>626930)
location: region:626502-626930:-1
so has part: feature:626502-626930:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:626502-626930:-1:exon

YLR245C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDD1
locus tag: YLR245C
EC number: 3.5.4.5
experiment: EXISTENCE:direct assay:GO:0004126 cytidine deaminase activity [PMID:10501935]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11292850|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11292850|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006216 cytidine catabolic process [PMID:10501935]
experiment: EXISTENCE:direct assay:GO:0006217 deoxycytidine catabolic process [PMID:10501935]
experiment: EXISTENCE:direct assay:GO:0008655 pyrimidine-containing compound salvage [PMID:10501935]
note: Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm
codon start: 1
product: cytidine deaminase
translation: MKVGGIEDRQLEALKRAALKACELSYSPYSHFRVGCSILTNNDVIFTGANVENASYSNCICAERSAMIQVLMAGHRSGWKCMVICGDSEDQCVSPCGVCRQFINEFVVKDFPIVMLNSTGSRSKVMTMGELLPMAFGPSHLN
SIO_010081: YLR245C
subclass of: SO_0000673
so part of: YLR245C
location: complement(626502..626930)
location: region:626502-626930:-1
so has part: feature:626502-626930:-1:exon

NP_013346.1
type: Protein
SIO_000068: ncbiprotein

S000004235
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:626502-626930:-1:exon

YLR246W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERF2
locus tag: YLR246W
so part of: sequence
location: <627118..>628197
location: region:627118-628197:1
so has part: feature:627118-628197:1:exon
subclass of: SO_0000010

850947
type: Gene
SIO_000068: ncbigene

position:627118:1
position: 627118
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:628197:1
position: 628197
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:627118-628197:1:exon

YLR246W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERF2
locus tag: YLR246W
product: palmitoyltransferase ERF2
transcript id: NM_001182133.1
SIO_010081: YLR246W
subclass of: SO_0000673
so part of: YLR246W
location: <627118..>628197
location: region:627118-628197:1
so has part: feature:627118-628197:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:627118-628197:1:exon

YLR246W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERF2
locus tag: YLR246W
EC number: 2.3.1.225
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10490616]
experiment: EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:12193598]
experiment: EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:12193598]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:10490616]
experiment: EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:12193598]
experiment: EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:10490616|PMID:16751107]
experiment: EXISTENCE:physical interaction:GO:0031211 endoplasmic reticulum palmitoyltransferase complex [PMID:12193598]
note: Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p
codon start: 1
product: palmitoyltransferase ERF2
translation: MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI
SIO_010081: YLR246W
subclass of: SO_0000673
so part of: YLR246W
location: 627118..628197
location: region:627118-628197:1
so has part: feature:627118-628197:1:exon

NP_013347.1
type: Protein
SIO_000068: ncbiprotein

S000004236
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:627118-628197:1:exon

YNCL0034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0034W
so part of: sequence
location: 628383..628497
location: region:628383-628497:1
so has part: feature:628383-628497:1:exon
subclass of: SO_0000663

850948
type: Gene
SIO_000068: ncbigene

position:628383:1
position: 628383
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:628497:1
position: 628497
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628383-628497:1:exon

YNCL0034W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0034W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCL0034W
subclass of: SO_0000673
so part of: YNCL0034W
location: join(628383..628420,628454..628497)
location: region:628383-628497:1
so has part: feature:628383-628420:1:exon
so has part: feature:628454-628497:1:exon

S000006643
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:628383-628420:1:exon

position:628420:1
position: 628420
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:628454-628497:1:exon

position:628454:1
position: 628454
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YLR247C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRC20
locus tag: YLR247C
so part of: sequence
location: complement(<628684..>633354)
location: region:628684-633354:-1
so has part: feature:628684-633354:-1:exon
subclass of: SO_0000010

850949
type: Gene
SIO_000068: ncbigene

position:628684:-1
position: 628684
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:633354:-1
position: 633354
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:628684-633354:-1:exon

YLR247C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRC20
locus tag: YLR247C
product: E3 ubiquitin-protein ligase IRC20
transcript id: NM_001182134.1
SIO_010081: YLR247C
subclass of: SO_0000673
so part of: YLR247C
location: complement(<628684..>633354)
location: region:628684-633354:-1
so has part: feature:628684-633354:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:628684-633354:-1:exon

YLR247C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRC20
locus tag: YLR247C
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:24155900]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:22367032]
experiment: EXISTENCE:genetic interaction:GO:0045003 double-strand break repair via synthesis-dependent strand annealing [PMID:22367032]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:24155900]
experiment: EXISTENCE:mutant phenotype:GO:0045003 double-strand break repair via synthesis-dependent strand annealing [PMID:22367032]
note: E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci
codon start: 1
product: E3 ubiquitin-protein ligase IRC20
translation: MSAVGALLAREYNVTAEKCDFFLENGSFDSVIAALPALNQEQETVTQKVSKNGKELINVASVNIEIPERISLSNNGRQLFKFIVDIEILPCENDNEATLVVSSDSVSLFQIGFKMENNSKIAVDKQLPLILDICAHKNQERALRNQLENRKSLERKPSRKRRKKNSNVNDPEKLLKSRIHELSLSYKDFECSPVVFRYNDSSLTWVLSFNLKLKFLNNKFNRFSVEANQILDLTFSNRDENEFERYHKHSHIHSNFIQKQFISQILEYSKDRLSKIKPFLPQSIPDLKVNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDEVGLIDFMNEYYAYGYELIARSPDEVGPSLLWNKLTGYILTTEDAAHLYNQYRKERLSGDYPVCAKGVLAEEMGLGKTIEILSLILLNRRKLKDSEATFIDDENRTITKTKTTLIICPNAILKQWLEEIELHANSLKWYTYRGYNEIMKDCKTVDEAVQQLCQYDIIVTSYNIIATEVHHAEFNRSIRSRRLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSAKCTSLLHRIHTWGVSGTPIQNIYNFRMIMSYLKLHPFCDEVDFIRTLQEEIKLRNEAKDYTSNDFVCQLKGVRFSIKDCMNIFYRYDLCIRHSKANVASQIHIPRQHNFIIPLEFAPIEWDNYLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYICCHALFPEILSTRQKRLHGHLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISNTPAKALESFIKIRDDLMIHIRQKFNVEDPFDKSLNLSEDEDEHMDERFGEKETSSGDESDREINGAKNHDNHNNDGMLSNHLKKKGLRAMMNLLHDCYFFLGSVYYNLGTRKLEEADDKHRKEKTEEVVYSDVFPKNELEEIEENRLLEQENYANAEILRKSILSSEARKVDMTIKMARTKFAPMTSNIPLRLINIEFDHKNDYSSNLAVSRCFKSLSKLIEGLNEQTKNFNELLDELLIIIYEPVHRTEDDDSTNKIIGNEEYSTSIDSQDKIFSLLGCLEIILQNRDNILTSESEVKIPKHLVPEGSIISKYQKQLLNSLRLISGTPLRTVFDELKNSRIVRRISSSNESESTIQNFEDYLLQYEVESKSLFKYNKQVRESLKILGSIYNAKTEYYSQLQRISDSLVSLHSLSAPQLSHLIRTINKSLGGTLDAKINNIESRLIYLKNLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSKCPICKGFCSISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEKLFGNKYEQFHQINEVHQIHIKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLKVIGKVLKLYHIEHLACLSNTANVGETINNFKRQPSVTCLLLNVKTLGAGLNLINAKHIFLLDPILNNSDELQAMGRNNRIGQDEETFVWNFMIRNTVEENILRYKCILEERKRKEKSKKGDKYDEAQDETDNEESDDAKFEISVVDQEVSNEHLWNCFFHGSD
SIO_010081: YLR247C
subclass of: SO_0000673
so part of: YLR247C
location: complement(628684..633354)
location: region:628684-633354:-1
so has part: feature:628684-633354:-1:exon

NP_013348.1
type: Protein
SIO_000068: ncbiprotein

S000004237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:628684-633354:-1:exon

YLR248W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLK1
alternative label: CMK3
gene: RCK2
locus tag: YLR248W
gene synonym: CLK1; CMK3
so part of: sequence
location: <634252..>636084
location: region:634252-636084:1
so has part: feature:634252-636084:1:exon
subclass of: SO_0000010

850950
type: Gene
SIO_000068: ncbigene

position:634252:1
position: 634252
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:636084:1
position: 636084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:634252-636084:1:exon

YLR248W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLK1
alternative label: CMK3
gene: RCK2
locus tag: YLR248W
gene synonym: CLK1; CMK3
product: serine/threonine protein kinase RCK2
transcript id: NM_001182135.1
SIO_010081: YLR248W
subclass of: SO_0000673
so part of: YLR248W
location: <634252..>636084
location: region:634252-636084:1
so has part: feature:634252-636084:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:634252-636084:1:exon

YLR248W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLK1
alternative label: CMK3
gene: RCK2
locus tag: YLR248W
gene synonym: CLK1; CMK3
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11344302]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8939941|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:11344302]
experiment: EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:11344302]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:16381815]
experiment: EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10778743]
experiment: EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:11344302]
note: Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase RCK2
translation: MLKIKALFSKKKPDQADLSQESKKPFKGKTRSSGTNNKDVSQITSSPKKSFQDKNIVQYPSVVADDHHMKSLTDELVTTIDSDSSPSDNITTENVETVTSVPAIDVHESSEGQLSSDPLISDESLSEQSEIISDIQDDSTDDDNMEDEIPEKSFLEQKELIGYKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDSTKTSSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLSRHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTPGVGGGGIGIVKLADFGLSKQIFSKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLLELEPSKRYDIDQFLDDPWLNTFDCLPKEGESSQKKAGTSERRHPHKKQFQLFQRDSSLLFSPAAVAMRDAFDIGNAVKRTEEDRMGTRGGLGSLAEDEELEDSYSGAQGDEQLEQNMFQLTLDTSTILQRRKKVQENDVGPTIPISATIRE
SIO_010081: YLR248W
subclass of: SO_0000673
so part of: YLR248W
location: 634252..636084
location: region:634252-636084:1
so has part: feature:634252-636084:1:exon

NP_013349.1
type: Protein
SIO_000068: ncbiprotein

S000004238
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:634252-636084:1:exon

YLR249W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TEF3
gene: YEF3
locus tag: YLR249W
gene synonym: TEF3
so part of: sequence
location: <636780..>639914
location: region:636780-639914:1
so has part: feature:636780-639914:1:exon
subclass of: SO_0000010

850951
type: Gene
SIO_000068: ncbigene

position:636780:1
position: 636780
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:639914:1
position: 639914
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:636780-639914:1:exon

YLR249W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TEF3
gene: YEF3
locus tag: YLR249W
gene synonym: TEF3
product: translation elongation factor EF-3
transcript id: NM_001182136.1
SIO_010081: YLR249W
subclass of: SO_0000673
so part of: YLR249W
location: <636780..>639914
location: region:636780-639914:1
so has part: feature:636780-639914:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:636780-639914:1:exon

YLR249W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TEF3
gene: YEF3
locus tag: YLR249W
gene synonym: TEF3
experiment: EXISTENCE:direct assay:GO:0003746 translation elongation factor activity [PMID:2670939]
experiment: EXISTENCE:direct assay:GO:0005840 ribosome [PMID:9553076]
experiment: EXISTENCE:direct assay:GO:0006415 translational termination [PMID:20534490]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:23451152]
experiment: EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:19666721]
experiment: EXISTENCE:direct assay:GO:0042788 polysomal ribosome [PMID:34916334]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:34916334]
experiment: EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:19666721]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:19666721|PMID:34916334]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16954224]
note: Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
codon start: 1
product: translation elongation factor EF-3
translation: MSDSQQSIKVLEELFQKLSVATADNRHEIASEVASFLNGNIIEHDVPEHFFGELAKGIKDKKTAANAMQAVAHIANQSNLSPSVEPYIVQLVPAICTNAGNKDKEIQSVASETLISIVNAVNPVAIKALLPHLTNAIVETNKWQEKIAILAAISAMVDAAKDQVALRMPELIPVLSETMWDTKKEVKAAATAAMTKATETVDNKDIERFIPSLIQCIADPTEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLNERETGIKRKSAVIIDNMCKLVEDPQVIAPFLGKLLPGLKSNFATIADPEAREVTLRALKTLRRVGNVGEDDAIPEVSHAGDVSTTLQVVNELLKDETVAPRFKIVVEYIAAIGADLIDERIIDQQAWFTHITPYMTIFLHEKKAKDILDEFRKRAVDNIPVGPNFDDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRARRYGICGPNGCGKSTLMRAIANGQVDGFPTQEECRTVYVEHDIDGTHSDTSVLDFVFESGVGTKEAIKDKLIEFGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNTCGITSITISHDSVFLDNVCEYIINYEGLKLRKYKGNFTEFVKKCPAAKAYEELSNTDLEFKFPEPGYLEGVKTKQKAIVKVTNMEFQYPGTSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRIAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWIPRGELVESHSKMVAEVDMKEALASGQFRPLTRKEIEEHCSMLGLDPEIVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKNLTEEVWAVKDGRMTPSGHNWVSGQGAGPRIEKKEDEEDKFDAMGNKIAGGKKKKKLSSAELRKKKKERMKKKKELGDAYVSSDEEF
SIO_010081: YLR249W
subclass of: SO_0000673
so part of: YLR249W
location: 636780..639914
location: region:636780-639914:1
so has part: feature:636780-639914:1:exon

NP_013350.1
type: Protein
SIO_000068: ncbiprotein

S000004239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:636780-639914:1:exon

YLR250W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSP120
locus tag: YLR250W
so part of: sequence
location: <640317..>641021
location: region:640317-641021:1
so has part: feature:640317-641021:1:exon
subclass of: SO_0000010

850952
type: Gene
SIO_000068: ncbigene

position:640317:1
position: 640317
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:641021:1
position: 641021
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:640317-641021:1:exon

YLR250W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSP120
locus tag: YLR250W
product: Ssp120p
transcript id: NM_001182137.1
SIO_010081: YLR250W
subclass of: SO_0000673
so part of: YLR250W
location: <640317..>641021
location: region:640317-641021:1
so has part: feature:640317-641021:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:640317-641021:1:exon

YLR250W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSP120
locus tag: YLR250W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Protein packaged into COPII vesicles for ER to Golgi trafficking; forms a complex with Emp47p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
codon start: 1
product: Ssp120p
translation: MRFLRGFVFSLAFTLYKVTATAEIGSEINVENEAPPDGLSWEEWHMDHEHQLKDYTPETFFALHDIKKKGFLDENDILSLYGLNREEIVGAGDGMGQHDESEKIDNEMAKRVVSLIMRLLDVDDNTKITKEEYLQFAKRGNKFPDLGVGVGHHSDFELEYEIHHWNKFHKDKDPDVKVVHKEDIEHELLHHEHEIEHEEEIQRGASRATVITDDELESRIELKNIPEKFKNGIF
SIO_010081: YLR250W
subclass of: SO_0000673
so part of: YLR250W
location: 640317..641021
location: region:640317-641021:1
so has part: feature:640317-641021:1:exon

NP_013351.1
type: Protein
SIO_000068: ncbiprotein

S000004240
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:640317-641021:1:exon

YLR251W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SYM1
locus tag: YLR251W
so part of: sequence
location: <641464..>642057
location: region:641464-642057:1
so has part: feature:641464-642057:1:exon
subclass of: SO_0000010

850953
type: Gene
SIO_000068: ncbigene

position:641464:1
position: 641464
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:642057:1
position: 642057
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:641464-642057:1:exon

YLR251W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SYM1
locus tag: YLR251W
product: ethanol metabolism protein
transcript id: NM_001182138.1
SIO_010081: YLR251W
subclass of: SO_0000673
so part of: YLR251W
location: <641464..>642057
location: region:641464-642057:1
so has part: feature:641464-642057:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:641464-642057:1:exon

YLR251W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SYM1
locus tag: YLR251W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15189984|PMID:23045398]
experiment: EXISTENCE:mutant phenotype:GO:0006067 ethanol metabolic process [PMID:15189984]
note: Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant
codon start: 1
product: ethanol metabolism protein
translation: MKLLHLYEASLKRRPKTTNAIMTGALFGIGDVSAQLLFPTSKVNKGYDYKRTARAVIYGSLIFSFIGDKWYKILNNKIYMRNRPQYHWSNMVLRVAVDQLAFAPLGLPFYFTCMSIMEGRSFDVAKLKIKEQWWPTLLTNWAVWPLFQAINFSVVPLQHRLLAVNVVAIFWNTYLSYKNSKVMEKDKVPVHYPPVVE
SIO_010081: YLR251W
subclass of: SO_0000673
so part of: YLR251W
location: 641464..642057
location: region:641464-642057:1
so has part: feature:641464-642057:1:exon

NP_013352.1
type: Protein
SIO_000068: ncbiprotein

S000004241
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:641464-642057:1:exon

YLR253W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MCP2
alternative label: MRX13
gene: CQD2
locus tag: YLR253W
gene synonym: MCP2; MRX13
so part of: sequence
location: <642627..>644336
location: region:642627-644336:1
so has part: feature:642627-644336:1:exon
subclass of: SO_0000010

850955
type: Gene
SIO_000068: ncbigene

position:642627:1
position: 642627
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:644336:1
position: 644336
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:642627-644336:1:exon

YLR253W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MCP2
alternative label: MRX13
gene: CQD2
locus tag: YLR253W
gene synonym: MCP2; MRX13
product: Cqd2p
transcript id: NM_001182140.1
SIO_010081: YLR253W
subclass of: SO_0000673
so part of: YLR253W
location: <642627..>644336
location: region:642627-644336:1
so has part: feature:642627-644336:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:642627-644336:1:exon

YLR253W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MCP2
alternative label: MRX13
gene: CQD2
locus tag: YLR253W
gene synonym: MCP2; MRX13
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23781023]
experiment: EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:23781023]
experiment: EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:23781023]
experiment: EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:23781023]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:23781023]
note: Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1
codon start: 1
product: Cqd2p
translation: MMTKAFFNKLPFEVFRRYVRTGKSIPQRSPRTRKSLLVGGTIASAVVLYNFNDTFHDSVKHTALTTKRIAVVTQATTRCFYHYKRALNKSYENKKEREVALNKCHKMCALITLHALRSNGGIYIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPESTYEEIDELFKEDLGTSIEDMFLEFNKTPIGVASLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIPLDVMLTRTVFELLDVFFPDYPLTWLGDELQSSIYVELNFTKEAENAEKTRHYFSKFKKQTALKIPKVIESHKRILIMEYVGGKRLDDLEYIDSHGISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGNLAIRSVKPAKDNGYHNFEIVLFDHGLYRYPSTRTRRLYAKFWLSLLFDKDQTKMKKYAKGFANITDEQFPLLAAAITGRSIDAALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRIPRVVLLILKTNDLTRHLDECLQNPLGPERTFLIMTQYCAKTVYDEKVERINSEYARWSIKWMWENLTNWIVYERRINQLYFYDFVLWWKKFIPKTWLSS
SIO_010081: YLR253W
subclass of: SO_0000673
so part of: YLR253W
location: 642627..644336
location: region:642627-644336:1
so has part: feature:642627-644336:1:exon

NP_013354.1
type: Protein
SIO_000068: ncbiprotein

S000004243
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:642627-644336:1:exon

YLR254C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NDL1
locus tag: YLR254C
so part of: sequence
location: complement(<644404..>644973)
location: region:644404-644973:-1
so has part: feature:644404-644973:-1:exon
subclass of: SO_0000010

850956
type: Gene
SIO_000068: ncbigene

position:644404:-1
position: 644404
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:644973:-1
position: 644973
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:644404-644973:-1:exon

YLR254C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NDL1
locus tag: YLR254C
product: Ndl1p
transcript id: NM_001182141.1
SIO_010081: YLR254C
subclass of: SO_0000673
so part of: YLR254C
location: complement(<644404..>644973)
location: region:644404-644973:-1
so has part: feature:644404-644973:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:644404-644973:-1:exon

YLR254C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NDL1
locus tag: YLR254C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15965467|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:15965467]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:15965467]
experiment: EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:15965467]
experiment: EXISTENCE:physical interaction:GO:0030473 nuclear migration along microtubule [PMID:15965467]
note: Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; localizes to cytosol, nucleus and peroxisomes
codon start: 1
product: Ndl1p
translation: MVPNLDLETAIQIISSLETQLSELEGATKEYENDLEQVISKLKSDLLESQQQNKCNKKQITDLEIQVDELENENIQLRNKIETLQLESDRRLERNVLLEHELLDTKEALQKLRVSKEEATSGETRRNTRSLPSQNKKMKLFKDTIKVSTTSSTLYLQNMAKTNNAARSHCNIPNTQITQSTVIATTSSV
SIO_010081: YLR254C
subclass of: SO_0000673
so part of: YLR254C
location: complement(644404..644973)
location: region:644404-644973:-1
so has part: feature:644404-644973:-1:exon

NP_013355.1
type: Protein
SIO_000068: ncbiprotein

S000004244
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:644404-644973:-1:exon

YLR255C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR255C
so part of: sequence
location: complement(<645600..>645953)
location: region:645600-645953:-1
so has part: feature:645600-645953:-1:exon
subclass of: SO_0000010

850957
type: Gene
SIO_000068: ncbigene

position:645600:-1
position: 645600
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:645953:-1
position: 645953
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:645600-645953:-1:exon

YLR255C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR255C
product: uncharacterized protein
transcript id: NM_001348858.1
SIO_010081: YLR255C
subclass of: SO_0000673
so part of: YLR255C
location: complement(<645600..>645953)
location: region:645600-645953:-1
so has part: feature:645600-645953:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:645600-645953:-1:exon

YLR255C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR255C
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MGVGGTRIVSFRQPNYYPVTQQKGASQTGAVAQPYSSYCGLLMRWAVVEIRRRGKGKGRKRKREREKGHTKFRIRRRSYLYFIRSCLVRPYSSGNKKNSCSFHKMLAIEIVLCLKAR
SIO_010081: YLR255C
subclass of: SO_0000673
so part of: YLR255C
location: complement(645600..645953)
location: region:645600-645953:-1
so has part: feature:645600-645953:-1:exon

NP_001335798.1
type: Protein
SIO_000068: ncbiprotein

S000004245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:645600-645953:-1:exon

YLR256W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP1
gene: HAP1
locus tag: YLR256W
gene synonym: CYP1
so part of: sequence
location: <646415..>650923
location: region:646415-650923:1
so has part: feature:646415-650923:1:exon
subclass of: SO_0000010

850958
type: Gene
SIO_000068: ncbigene

position:646415:1
position: 646415
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:650923:1
position: 650923
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:646415-650923:1:exon

YLR256W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP1
gene: HAP1
locus tag: YLR256W
gene synonym: CYP1
product: Hap1p
transcript id: NM_001182143.1
SIO_010081: YLR256W
subclass of: SO_0000673
so part of: YLR256W
location: <646415..>650923
location: region:646415-650923:1
so has part: feature:646415-650923:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:646415-650923:1:exon

YLR256W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP1
gene: HAP1
locus tag: YLR256W
gene synonym: CYP1
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:3030565|PMID:9118994]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2823123]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25378625|PMID:8182072]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25378625]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:genetic interaction:GO:0043457 regulation of cellular respiration [PMID:2851658]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17785431]
experiment: EXISTENCE:mutant phenotype:GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter [PMID:2823123]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2823123]
experiment: EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2182199]
experiment: EXISTENCE:mutant phenotype:GO:0071169 establishment of protein localization to chromatin [PMID:17785431]
note: Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
codon start: 1
product: Hap1p
translation: MSNTPYNSSVPSIASMTQSSVSRSPNMHTATTPGANTSSNSPPLHMSSDSSKIKRKRNRIPLSCTICRKRKVKCDKLRPHCQQCTKTGVAHLCHYMEQTWAEEAEKELLKDNELKKLRERVKSLEKTLSKVHSSPSSNSLKSYNTPESSNLFMGSDEHTTLVNANTGSASSASHMHQQQQQQQQQEQQQDFSRSANANANSSSLSISNKYDNDELDLTKDFDLLHIKSNGTIHLGATHWLSIMKGDPYLKLLWGHIFAMREKLNEWYYQKNSYSKLKSSKCPINHAQAPPSAAAAATRKCPVDHSAFSSGMVAPKEETPLPRKCPVDHTMFSSGMIPPREDTSSQKRCPVDHTMYSAGMMPPKDETPSPFSTKAMIDHNKHTMNPPQSKCPVDHRNYMKDYPSDMANSSSNPASRCPIDHSSMKNTAALPASTHNTIPHHQPQSGSHARSHPAQSRKHDSYMTESEVLATLCEMLPPKRVIALFIEKFFKHLYPAIPILDEQNFKNHVNQMLSLSSMNPTVNNFGMSMPSSSTLENQPITQINLPKLSDSCNLGILIIILRLTWLSIPSNSCEVDLGEESGSFLVPNESSNMSASALTSMAKEESLLLKHETPVEALELCQKYLIKFDELSSISNNNVNLTTVQFAIFYNFYMKSASNDLTTLTNTNNTGMANPGHDSESHQILLSNITQMAFSCGLHRDPDNFPQLNATIPATSQDVSNNGSKKANPSTNPTLNNNMSAATTNSSSRSGSADSRSGSNPVNKKENQVSIERFKHTWRKIWYYIVSMDVNQSLSLGSPRLLRNLRDFSDTKLPSASRIDYVRDIKELIIVKNFTLFFQIDLCIIAVLNHILNVSLARSVRKFELDSLINLLKNLTYGTENVNDVVSSLINKGLLPTSEGGSVDSNNDEIYGLPKLPDILNHGQHNQNLYADGRNTSSSDIDKKLDLPHESTTRALFFSKHMTIRMLLYLLNYILFTHYEPMGSEDPGTNILAKEYAQEALNFAMDGYRNCMIFFNNIRNTNSLFDYMNVILSYPCLDIGHRSLQFIVCLILRAKCGPLTGMRESSIITNGTSSGFNSSVEDEDVKVKQESSDELKKDDFMKDVNLDSGDSLAEILMSRMLLFQKLTKQLSKKYNYAIRMNKSTGFFVSLLDTPSKKSDSKSGGSSFMLGNWKHPKVSNMSGFLAGDKDQLQKCPVYQDALGFVSPTGANEGSAPMQGMSLQGSTARMGGTQLPPIRSYKPITYTSSNLRRMNETGEAEAKRRRFNDGYIDNNSNNDIPRGISPKPSNGLSSVQPLLSSFSMNQLNGGTIPTVPSLTNITSQMGALPSLDRITTNQINLPDPSRDEAFDNSIKQMTPMTSAFMNANTTIPSSTLNGNMNMNGAGTANTDTSANGSALSTLTSPQGSDLASNSATQYKPDLEDFLMQNSNFNGLMINPSSLVEVVGGYNDPNNLGRNDAVDFLPVDNVEIDGVGIKINYHLLTSIYVTSILSYTVLEDDANDEK
SIO_010081: YLR256W
subclass of: SO_0000673
so part of: YLR256W
location: 646415..650923
location: region:646415-650923:1
so has part: feature:646415-650923:1:exon

NP_013357.1
type: Protein
SIO_000068: ncbiprotein

S000004246
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:646415-650923:1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YLRWTy1-3; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YLRWTy1-3
so part of: sequence
location: 650824..656743
location: region:650824-656743:1
so has part: feature:650824-656743:1:region

S000007099
type: SGD
SIO_000068: sgd

position:650824:1
position: 650824
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:656743:1
position: 656743
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:650824-656743:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 650824..651157
location: region:650824-651157:1
so has part: feature:650824-651157:1:region

S000007088
type: SGD
SIO_000068: sgd

position:651157:1
position: 651157
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:650824-651157:1:region

YLR256W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR256W-A
so part of: sequence
location: <651117..>652439
location: region:651117-652439:1
so has part: feature:651117-652439:1:exon
subclass of: SO_0000010

850959
type: Gene
SIO_000068: ncbigene

position:651117:1
position: 651117
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:652439:1
position: 652439
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:651117-652439:1:exon

YLR256W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR256W-A
product: gag protein
transcript id: NM_001184409.1
SIO_010081: YLR256W-A
subclass of: SO_0000673
so part of: YLR256W-A
location: <651117..>652439
location: region:651117-652439:1
so has part: feature:651117-652439:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:651117-652439:1:exon

YLR256W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR256W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHPHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YLR256W-A
subclass of: SO_0000673
so part of: YLR256W-A
location: 651117..652439
location: region:651117-652439:1
so has part: feature:651117-652439:1:exon

NP_058173.1
type: Protein
SIO_000068: ncbiprotein

S000007377
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:651117-652439:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 656410..656743
location: region:656410-656743:1
so has part: feature:656410-656743:1:region

S000007089
type: SGD
SIO_000068: sgd

position:656410:1
position: 656410
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:656410-656743:1:region

YNCL0035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCL0035C
so part of: sequence
location: complement(656934..657006)
location: region:656934-657006:-1
so has part: feature:656934-657006:-1:exon
subclass of: SO_0000663

850960
type: Gene
SIO_000068: ncbigene

position:656934:-1
position: 656934
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:657006:-1
position: 657006
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:656934-657006:-1:exon

YNCL0035C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCL0035C
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCL0035C
subclass of: SO_0000673
so part of: YNCL0035C
location: complement(656934..657006)
location: region:656934-657006:-1
so has part: feature:656934-657006:-1:exon

S000006517
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:656934-657006:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 657022..657365
location: region:657022-657365:1
so has part: feature:657022-657365:1:region

S000007096
type: SGD
SIO_000068: sgd

position:657022:1
position: 657022
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:657365:1
position: 657365
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:657022-657365:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 657449..657767
location: region:657449-657767:1
so has part: feature:657449-657767:1:region

S000007090
type: SGD
SIO_000068: sgd

position:657449:1
position: 657449
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:657767:1
position: 657767
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:657449-657767:1:region

YLR257W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YLR257W
so part of: sequence
location: <658826..>659791
location: region:658826-659791:1
so has part: feature:658826-659791:1:exon
subclass of: SO_0000010

850961
type: Gene
SIO_000068: ncbigene

position:658826:1
position: 658826
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:659791:1
position: 659791
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:658826-659791:1:exon

YLR257W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YLR257W
product: uncharacterized protein
transcript id: NM_001182144.1
SIO_010081: YLR257W
subclass of: SO_0000673
so part of: YLR257W
location: <658826..>659791
location: region:658826-659791:1
so has part: feature:658826-659791:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:658826-659791:1:exon

YLR257W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YLR257W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
note: hypothetical protein; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MVDARGSTPCLIGDSIRNVNDGNSLDFQYTNQFNEESEASRLLTPQTSSNHALSKMQKDDDIRDRSYTSVAELNREGALLTDEVDLENVDASKVRSNRDDLEAEEKRKKLLLLKKKQRNKSINSESFSSPSLRASKSNSLITSTDPVEDHISKYSSSGTPENITGEADDEDEDIIRNSYGQMIKNNSNRPHLAKGESYQSAEQEIDHTAPEKSEKRQERSGRSFDRQKSSAEFLRSLSRSISRGPTKNKTVSPSKGEDSRMYSTSNYSISLVDLENGPKIIPETLEEEQEDAEKEGVLMEDEGNEEYTKDLEEAANKAQPQ
SIO_010081: YLR257W
subclass of: SO_0000673
so part of: YLR257W
location: 658826..659791
location: region:658826-659791:1
so has part: feature:658826-659791:1:exon

NP_013358.1
type: Protein
SIO_000068: ncbiprotein

S000004247
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:658826-659791:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1220; Autonomously Replicating Sequence
so part of: sequence
location: 659884..659935
location: region:659884-659935:1
so has part: feature:659884-659935:1:region

S000118478
type: SGD
SIO_000068: sgd

position:659884:1
position: 659884
reference: sequence
type: ForwardStrandPosition
type: ExactPosition