Saccharomyces cerevisiae S288C chromosome XI, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome XI, complete sequence.
sequence version: NC_001143.9
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001143.9
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 8849441
reference: 3
references: 8196765
reference: 4
reference: 5
reference: 6
reference: 7
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006944.\n\nOn Apr 26, 2011 this sequence version replaced NC_001143.8.\nChromosome XI sequence was verified by resequencing. The sequence\nwas mapped to the previous GenBank records except for a 500 bp\nregion. That region was determined by sequencing a descendant of\nthe S288C strain, AB972, and is present in GenBank as JF740677.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##

sequence
subclass of: SO_0000340
sequence length: 666816
topology: linear
so has quality: SO_0000987
location: 1..666816
location: region:1-666816:1
RO_0002162: 559292

NC_001143
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

3
title: Complete DNA sequence of yeast chromosome XI
author: Dujon, B.
author: Alexandraki, D.
author: Andre, B.
author: Ansorge, W.
author: Baladron, V.
author: Ballesta, J.P.
author: Banrevi, A.
author: Bolle, P.A.
author: Bolotin-Fukuhara, M.
author: Bossier, P. et al.
journal: Nature
volume: 369
issue: 6479
pages: 371-378
year: 1994
pubmed: 8196765

8196765
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

7
title: Direct Submission
journal: Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:666816:1
position: 666816
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-666816:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: XI

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL11L; Telomeric region on the left arm of Chromosome XI; composed of an X element core sequence, X element combinatorial repeats, and a short terminal stretch of telomeric repeats
so part of: sequence
location: complement(1..807)
location: region:1-807:-1
so has part: feature:1-807:-1:region

S000028906
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:807:-1
position: 807
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-807:-1:region

YKL224C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU16
locus tag: YKL224C
so part of: sequence
location: complement(<1810..>2181)
location: region:1810-2181:-1
so has part: feature:1810-2181:-1:exon
subclass of: SO_0000010

853656
type: Gene
SIO_000068: ncbigene

position:1810:-1
position: 1810
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:2181:-1
position: 2181
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1810-2181:-1:exon

YKL224C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU16
locus tag: YKL224C
product: seripauperin PAU16
transcript id: NM_001179789.1
SIO_010081: YKL224C
subclass of: SO_0000673
so part of: YKL224C
location: complement(<1810..>2181)
location: region:1810-2181:-1
so has part: feature:1810-2181:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:1810-2181:-1:exon

YKL224C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU16
locus tag: YKL224C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole
codon start: 1
product: seripauperin PAU16
translation: MVKLTSIAAGVAAIAAGVAAAPATTTLSPSDERVNLVELGVYVSDIRAHLAQYYLFQAAHPSETYPVEIAEAVFNYGDFTTMLTGIPAEQVTRVITGVPWYSTRLRPAISSALSKDGIYTIAN
SIO_010081: YKL224C
subclass of: SO_0000673
so part of: YKL224C
location: complement(1810..2181)
location: region:1810-2181:-1
so has part: feature:1810-2181:-1:exon

NP_012698.1
type: Protein
SIO_000068: ncbiprotein

S000001707
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:1810-2181:-1:exon

YKL222C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL222C
so part of: sequence
location: complement(<3503..>5620)
location: region:3503-5620:-1
so has part: feature:3503-5620:-1:exon
subclass of: SO_0000010

853658
type: Gene
SIO_000068: ncbigene

position:3503:-1
position: 3503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5620:-1
position: 5620
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3503-5620:-1:exon

YKL222C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL222C
product: uncharacterized protein
transcript id: NM_001179787.1
SIO_010081: YKL222C
subclass of: SO_0000673
so part of: YKL222C
location: complement(<3503..>5620)
location: region:3503-5620:-1
so has part: feature:3503-5620:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:3503-5620:-1:exon

YKL222C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL222C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:21777356]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
codon start: 1
product: uncharacterized protein
translation: MKNTELSQKKKLDRQSRRKPAKSCHFCRVRKLKCDRVRPFCGSCSSRNRKQCEYKENTSAMEDQLRKKYRRCSKLEMARRIEELESQLTKQSQPNIHEGQNPLSNMRYLSSKHNRHILYGPTSYRAILATQTDTFAKYREEIWQVLKLSRNNWKREHHYSTLSEISSIETAPPHSGSPSVIEYLCESLPNYEVLCEYLTDFFASDFYDSYQIVHKEKVLRDLQDCFVKGPRSHKTGQHTIISLNLDSKKNYYKVGVMTAIMCLASHPKEVPEAIEVFHKVLTSFVSAKVFYTERVQFLFLRYLYINVAGLDGGDQSHCIFIHGLTIDTAIHMGLNEDLRRLYLSKNHPIEEIPYLERLWLWILFTDVKISLSTGIPVRINDDFVNKVRLENYSSSGDILLYKTTLRLRNIMKQIHAREKPPDIPLIIEDLKKFTIKMFKPLDFYLNASNLNGNEFTELQLWHATLHMIGSLSNLYTLTHQDFDARIFNFSVLAPLNSLHLCFNVLETYFELDNSKLSSKSLCLSKKWPHLNNALFLIYVNAFRALIQIYTIFLQYMENKDIQLFIQRNSSALTYSICPGDFEGPHNKCISLKIAFKEMENIFDHIHQEKLKPLTQIWQNSYYFSIIISMEKIGRRAFNKGMKNIDEGPETENDATENSLTTILNDLEGPLEDFSENFIDDILGSPSAFFDTAISGWSNFEDFFSR
SIO_010081: YKL222C
subclass of: SO_0000673
so part of: YKL222C
location: complement(3503..5620)
location: region:3503-5620:-1
so has part: feature:3503-5620:-1:exon

NP_012700.1
type: Protein
SIO_000068: ncbiprotein

S000001705
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:3503-5620:-1:exon

YKL221W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCH2
locus tag: YKL221W
so part of: sequence
location: <6107..>7528
location: region:6107-7528:1
so has part: feature:6107-7528:1:exon
subclass of: SO_0000010

853659
type: Gene
SIO_000068: ncbigene

position:6107:1
position: 6107
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:7528:1
position: 7528
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6107-7528:1:exon

YKL221W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCH2
locus tag: YKL221W
product: Mch2p
transcript id: NM_001179786.2
SIO_010081: YKL221W
subclass of: SO_0000673
so part of: YKL221W
location: <6107..>7528
location: region:6107-7528:1
so has part: feature:6107-7528:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6107-7528:1:exon

YKL221W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCH2
locus tag: YKL221W
note: Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport
codon start: 1
product: Mch2p
translation: MSEERHEDHHRDVENKLNLNGKDDINGNTSISIEVPDGGYGWFILLAFILYNFSTWGANSGYAIYLAHYLENNTFAGGSKLDYASIGGLAFSCGLFFAPVITWLYHIFSIQFIIGLGILFQGAALLLAAFSVTLWEIYLTQGVLIGFGLAFIFIPSVTLIPLWFRNKRSLASGIGTAGSGLGGIVFNLGMQSILQKRGVKWALIAQCIICTSLSTIALMLTRTTHQGLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSFAMLGYVVLLYSLSDFTVSLGYTSKQGSYVSCMVSVGSLLGRPIVGHIADKYGSLTVGMILHLVMAILCWAMWIPCKNLATAIAFGLLVGSIMGTIWPTIASIVTRIVGLQKLPGTFGSTWIFMAAFALVAPIIGLELRSTDTNGNDYYRTAIFVGFAYFGVSLCQWLLRGFIIARDEIAVREAYSADQNELHLNVKLSHMSKCLFRYKQLPRRV
SIO_010081: YKL221W
subclass of: SO_0000673
so part of: YKL221W
location: 6107..7528
location: region:6107-7528:1
so has part: feature:6107-7528:1:exon

NP_012701.2
type: Protein
SIO_000068: ncbiprotein

S000001704
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6107-7528:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1102; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 7528..8309
location: region:7528-8309:1
so has part: feature:7528-8309:1:region

S000130137
type: SGD
SIO_000068: sgd

position:8309:1
position: 8309
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7528-8309:1:region

YKL220C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRE2
locus tag: YKL220C
so part of: sequence
location: complement(<9091..>11226)
location: region:9091-11226:-1
so has part: feature:9091-11226:-1:exon
subclass of: SO_0000010

853660
type: Gene
SIO_000068: ncbigene

position:9091:-1
position: 9091
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:11226:-1
position: 11226
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:9091-11226:-1:exon

YKL220C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRE2
locus tag: YKL220C
product: ferric/cupric-chelate reductase
transcript id: NM_001179785.1
SIO_010081: YKL220C
subclass of: SO_0000673
so part of: YKL220C
location: complement(<9091..>11226)
location: region:9091-11226:-1
so has part: feature:9091-11226:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:9091-11226:-1:exon

YKL220C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRE2
locus tag: YKL220C
EC number: 1.16.1.9
experiment: EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:31322728]
experiment: EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:8164662]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8164662]
experiment: EXISTENCE:direct assay:GO:0006826 iron ion transport [PMID:8164662]
experiment: EXISTENCE:direct assay:GO:0015677 copper ion import [PMID:9153234]
note: Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
codon start: 1
product: ferric/cupric-chelate reductase
translation: MHWTSILSAILLFCLSGARASPAKTVIRNKVPLLVTNACTRIFQKVTWEYTSKSKRSSPVCSYEPAFQSMLYCIYETLDEKGYSNKTLEKTFSTIKKNCASYSDALQNMTNSEFYDVLNNGTRHMTPYVKGSANLTYPVEMDTQLRKAYYHALHGFYANLDVGNIYGGIICAYFVAIMAFAGVLHCMNYTPFKTVLLKQKLVGYVRGYLTLPTIGSKHASDFSYFRIFTGYLPTRLEGIIILGYLVLHTVFLAYGYEYDPENIIFKSRRVQVARYVADRSGVLAFAHFPLIVLFAGRNNFLEYISGVKYTSFIMFHKWLGRMMFLDAMIHGSAYTSYTVANKTWATSKNRLYWQFGVAALCLAGTMVFFSFAVFRKYFYEAFLFLHIVLGAMFFYACWEHVVSLSGIEWIYTAIAIWIVDRIIRIIKASYFGFPKASLQLIGDDLIRLTVKKPARPWRAKPGQYVFVSFLHPLYFWQSHPFTVLDSVSKNGELVIILKEKKGVTRLVKKYVCRNGGKTSMRLAIEGPYGSSSPVNNYNNVLLLTGGTGLPGPIAHAIKLGKTSAAAGKQSVKLVIAVRGFDVLEAYKPELMCLENLNVQLHIYNTMEVPSLTPSDSLDISQQDEKADEKGTVVATTLEKSANPLGFDGVVFHCGRPNVKELLHEAAELSGSLSVVCCGPPIFVDKVRNETAKIVLDKSAKAIEYFEEYQCW
SIO_010081: YKL220C
subclass of: SO_0000673
so part of: YKL220C
location: complement(9091..11226)
location: region:9091-11226:-1
so has part: feature:9091-11226:-1:exon

NP_012702.1
type: Protein
SIO_000068: ncbiprotein

S000001703
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:9091-11226:-1:exon

YKL219W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS9
locus tag: YKL219W
so part of: sequence
location: <14485..>15708
location: region:14485-15708:1
so has part: feature:14485-15708:1:exon
subclass of: SO_0000010

853661
type: Gene
SIO_000068: ncbigene

position:14485:1
position: 14485
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:15708:1
position: 15708
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14485-15708:1:exon

YKL219W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS9
locus tag: YKL219W
product: Cos9p
transcript id: NM_001179784.1
SIO_010081: YKL219W
subclass of: SO_0000673
so part of: YKL219W
location: <14485..>15708
location: region:14485-15708:1
so has part: feature:14485-15708:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14485-15708:1:exon

YKL219W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS9
locus tag: YKL219W
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
codon start: 1
product: Cos9p
translation: MQIVRSCNSNNKPLIPSSNWHIAIRMRGDGVKDRSIDVLSLKHFESQKVVLPQDLFMDNFTWMFYEFFKCFTFRTWLLLLLLMWLPGFLSQIKSINRIFPFKLCILVSCLVGIFLPNIYSFSHKSVLTNQLTQFSKEIVEHAPGTDTHDWETVAANLNSYFYENKAWNTEYFFFNAAECQKAFRKVLLEPFSVKKDESSKIKSFGDSVPYIEEALQVYSTEFDKKWKLFNTEKVWSPDNLEHVQLPKKTYRYKFTWVLKRIFNLWLFPAFILFLACIYVSWDKGHLFRILCCGGGFLLMVRVFQNMRPFSMHMEDKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWTSEEFFFDGIDCEWFFNHFFYRLLSTKKPMFDRPLNVELWPYIKEAQLTRKQAPPV
SIO_010081: YKL219W
subclass of: SO_0000673
so part of: YKL219W
location: 14485..15708
location: region:14485-15708:1
so has part: feature:14485-15708:1:exon

NP_012703.1
type: Protein
SIO_000068: ncbiprotein

S000001702
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14485-15708:1:exon

YKL218C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRY1
locus tag: YKL218C
so part of: sequence
location: complement(<17359..>18339)
location: region:17359-18339:-1
so has part: feature:17359-18339:-1:exon
subclass of: SO_0000010

853662
type: Gene
SIO_000068: ncbigene

position:17359:-1
position: 17359
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:18339:-1
position: 18339
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17359-18339:-1:exon

YKL218C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRY1
locus tag: YKL218C
product: threo-3-hydroxy-L-aspartate ammonia-lyase SRY1
transcript id: NM_001179783.1
SIO_010081: YKL218C
subclass of: SO_0000673
so part of: YKL218C
location: complement(<17359..>18339)
location: region:17359-18339:-1
so has part: feature:17359-18339:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17359-18339:-1:exon

YKL218C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRY1
locus tag: YKL218C
EC number: 4.3.1.16
experiment: EXISTENCE:direct assay:GO:0030848 threo-3-hydroxyaspartate ammonia-lyase activity [PMID:12951240]
experiment: EXISTENCE:direct assay:GO:0042219 cellular modified amino acid catabolic process [PMID:12951240]
experiment: EXISTENCE:mutant phenotype:GO:0030848 threo-3-hydroxyaspartate ammonia-lyase activity [PMID:12951240]
experiment: EXISTENCE:mutant phenotype:GO:0042219 cellular modified amino acid catabolic process [PMID:12951240]
note: 3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
codon start: 1
product: threo-3-hydroxy-L-aspartate ammonia-lyase SRY1
translation: MIVPTYGDVLDASNRIKEYVNKTPVLTSRMLNDRLGAQIYFKGENFQRVGAFKFRGAMNAVSKLSDEKRSKGVIAFSSGNHAQAIALSAKLLNVPATIVMPEDAPALKVAATAGYGAHIIRYNRYTEDREQIGRQLAAEHGFALIPPYDHPDVIAGQGTSAKELLEEVGQLDALFVPLGGGGLLSGSALAARSLSPGCKIFGVEPEAGNDGQQSFRSGSIVHINTPKTIADGAQTQHLGEYTFAIIRENVDDILTVSDQELVKCMHFLAERMKVVVEPTACLGFAGALLKKEELVGKKVGIILSGGNVDMKRYATLISGKEDGPTI
SIO_010081: YKL218C
subclass of: SO_0000673
so part of: YKL218C
location: complement(17359..18339)
location: region:17359-18339:-1
so has part: feature:17359-18339:-1:exon

NP_012704.1
type: Protein
SIO_000068: ncbiprotein

S000001701
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17359-18339:-1:exon

YKL217W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: JEN1
locus tag: YKL217W
so part of: sequence
location: <22234..>24084
location: region:22234-24084:1
so has part: feature:22234-24084:1:exon
subclass of: SO_0000010

853663
type: Gene
SIO_000068: ncbigene

position:22234:1
position: 22234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:24084:1
position: 24084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22234-24084:1:exon

YKL217W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: JEN1
locus tag: YKL217W
product: monocarboxylate/H+ symporter
transcript id: NM_001179782.1
SIO_010081: YKL217W
subclass of: SO_0000673
so part of: YKL217W
location: <22234..>24084
location: region:22234-24084:1
so has part: feature:22234-24084:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:22234-24084:1:exon

YKL217W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: JEN1
locus tag: YKL217W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17710650]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006849 plasma membrane pyruvate transport [PMID:17710650]
experiment: EXISTENCE:mutant phenotype:GO:0015355 secondary active monocarboxylate transmembrane transporter activity [PMID:17710650]
experiment: EXISTENCE:mutant phenotype:GO:0035879 plasma membrane lactate transport [PMID:10198029|PMID:17710650]
experiment: EXISTENCE:mutant phenotype:GO:0097079 selenite:proton symporter activity [PMID:20861301]
experiment: EXISTENCE:mutant phenotype:GO:0097080 plasma membrane selenite transport [PMID:20861301]
note: Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
codon start: 1
product: monocarboxylate/H+ symporter
translation: MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRTVQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGMIFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHLAELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAILTGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKMIDSNVSKTYEEHIETV
SIO_010081: YKL217W
subclass of: SO_0000673
so part of: YKL217W
location: 22234..24084
location: region:22234-24084:1
so has part: feature:22234-24084:1:exon

NP_012705.1
type: Protein
SIO_000068: ncbiprotein

S000001700
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:22234-24084:1:exon

YKL216W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: URA1
locus tag: YKL216W
so part of: sequence
location: <25215..>26159
location: region:25215-26159:1
so has part: feature:25215-26159:1:exon
subclass of: SO_0000010

853664
type: Gene
SIO_000068: ncbigene

position:25215:1
position: 25215
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26159:1
position: 26159
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25215-26159:1:exon

YKL216W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: URA1
locus tag: YKL216W
product: dihydroorotate dehydrogenase
transcript id: NM_001179781.1
SIO_010081: YKL216W
subclass of: SO_0000673
so part of: YKL216W
location: <25215..>26159
location: region:25215-26159:1
so has part: feature:25215-26159:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25215-26159:1:exon

YKL216W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: URA1
locus tag: YKL216W
EC number: 1.3.98.1
experiment: EXISTENCE:direct assay:GO:0004152 dihydroorotate dehydrogenase activity [PMID:1511880]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1409592]
experiment: EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:10871048]
experiment: EXISTENCE:mutant phenotype:GO:0004152 dihydroorotate dehydrogenase activity [PMID:4550660]
experiment: EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:5651325|PMID:4550660]
note: Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
codon start: 1
product: dihydroorotate dehydrogenase
translation: MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
SIO_010081: YKL216W
subclass of: SO_0000673
so part of: YKL216W
location: 25215..26159
location: region:25215-26159:1
so has part: feature:25215-26159:1:exon

NP_012706.1
type: Protein
SIO_000068: ncbiprotein

S000001699
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25215-26159:1:exon

YKL215C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OXP1
locus tag: YKL215C
so part of: sequence
location: complement(<26827..>30687)
location: region:26827-30687:-1
so has part: feature:26827-30687:-1:exon
subclass of: SO_0000010

853665
type: Gene
SIO_000068: ncbigene

position:26827:-1
position: 26827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:30687:-1
position: 30687
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26827-30687:-1:exon

YKL215C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OXP1
locus tag: YKL215C
product: 5-oxoprolinase
transcript id: NM_001179780.1
SIO_010081: YKL215C
subclass of: SO_0000673
so part of: YKL215C
location: complement(<26827..>30687)
location: region:26827-30687:-1
so has part: feature:26827-30687:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26827-30687:-1:exon

YKL215C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OXP1
locus tag: YKL215C
EC number: 3.5.2.9
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity [PMID:20402795]
experiment: EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:20349993]
experiment: EXISTENCE:mutant phenotype:GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity [PMID:20402795]
note: 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
codon start: 1
product: 5-oxoprolinase
translation: MQKGNIRIAIDKGGTFTDCVGNIGTGKQEHDTVIKLLSVDPKNYPDAPLEGIRRLLEVLEHKTIPRGIPLDISNVRSLRMGTTLATNCALERNGERCAFITTKGFKDSLLIGDQTRPDIFNLNIKKVVPLYDTVVEIDERVTLEDFSEDPYFTKSSPNEQEGILEGNSGEMVRVIKKPDESSVRSILKVLYASGIKSIAIAFLHSYTFPDHERIVGNIAREIGFSHVSLSSEVSPMIKFLPRAHSSVADAYLTPVIKKYLNSISAGLSHAEDTHIQFMQSDGGLVDGGKFSGLKSILSGPAGGVIGYSSTCYDKNNNIPLIGFDMGGTSTDVSRYGDGRLEHVFETVTAGIIIQSPQLDIHTVAAGGSSILSWKNGLFRVGPDSAAADPGPAAYRKGGPLTITDANLFLGRLVPEFFPKIFGPNEDESLDLETTTLKFRELTDVINKDLNSNLTMEEVAYGFIKVANECMARPVRAITEAKGHVVSQHRLVSFGGAGGQHAIAVADSLGIDTVLIHRYSSILSAYGIFLADVIEENQEPCSFILGEPETILKVKKRFLELSKNSIKNLLSQSFSREDIVLERYLNLRYEGTETSLMILQKYDDQWNFREWFSEAHKKEFGFSFDDKRIIIDDIRIRAIGKSGVRKEKTVDEQLIEISHFKKADVSKDASFTQKAYFDNKWVDTAVFKIDDLPAGTIIEGPAILADGTQTNIILPNSQATILNSHIFIKINQKAAKTLSKSGYELDIDPILLSIFSHRFMDIALQMGTQLRKTSVSTNVKERLDFSCALFDSKGNLVANAPHVPVHLGSMSTCISAQAKLWEGKLKPGDVLITNHPDIGGTHLPDITVITPSFSSTGELIFYVASRAHHADIGGILPGSVPPNSKELYEEGTAIYSELVVKEGIFQEELIYKLFVEDPGKYPGCSGSRRFSDNISDLKAQVAANTKGIQLIGSLTKEYDLATILKYMAAIQTNASESIKKMLAKMVEHFGTTKFSGEDRLDDGSLIKLQVIIRPEKEEYIFNFDGTSPQVYGNLNAPEAITNSAILYCLRCLVGEDIPLNQGCLKPLTIKIPAGSLLSPRSGAAVVGGNVLTSQRVTDVILKTFNVMADSQGDCNNFTFGTGGNSGNKTDKQIKGFGYYETICGGSGAGADSWRGSGWNGSDAVHTNMTNTRMTDTEVFERRYPVLLKEFSIRRGSGGKGKYTGGNGVVRDVQFRKAVTASILSERRVIGPHGIKGGQDGSRGENLWVRHSTGALINVGGKNTIYAQPGDRFIIKTPGGGGFGQYKD
SIO_010081: YKL215C
subclass of: SO_0000673
so part of: YKL215C
location: complement(26827..30687)
location: region:26827-30687:-1
so has part: feature:26827-30687:-1:exon

NP_012707.1
type: Protein
SIO_000068: ncbiprotein

S000001698
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26827-30687:-1:exon

YKL214C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YRA2
locus tag: YKL214C
so part of: sequence
location: complement(<31082..>31693)
location: region:31082-31693:-1
so has part: feature:31082-31693:-1:exon
subclass of: SO_0000010

853666
type: Gene
SIO_000068: ncbigene

position:31082:-1
position: 31082
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31693:-1
position: 31693
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31082-31693:-1:exon

YKL214C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YRA2
locus tag: YKL214C
product: Yra2p
transcript id: NM_001179779.1
SIO_010081: YKL214C
subclass of: SO_0000673
so part of: YKL214C
location: complement(<31082..>31693)
location: region:31082-31693:-1
so has part: feature:31082-31693:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31082-31693:-1:exon

YKL214C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YRA2
locus tag: YKL214C
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11390651]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11390651]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:11390651]
note: Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
codon start: 1
product: Yra2p
translation: MDKAFDEIIGNSHTDSSSNHKVTRYRRRDLRNELGPRLGFAPSDAASRSKDRLYREREEPPLPKRIRISKIPLDVSDYTLDDMIKEFGSPIFSKIFDNKEDRTCIYEFEDPEVLEKIVERYNGHELHNAKIEVEIYQPQRKHSRMNAHNRRKQTAQEHGRGRPGSHYRQKPNRVSKKNKGREKNNTPTSVEALDAELDAYMKG
SIO_010081: YKL214C
subclass of: SO_0000673
so part of: YKL214C
location: complement(31082..31693)
location: region:31082-31693:-1
so has part: feature:31082-31693:-1:exon

NP_012708.1
type: Protein
SIO_000068: ncbiprotein

S000001697
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31082-31693:-1:exon

YKL213C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UFD3
alternative label: ZZZ4
gene: DOA1
locus tag: YKL213C
gene synonym: UFD3; ZZZ4
so part of: sequence
location: complement(<31960..>34107)
location: region:31960-34107:-1
so has part: feature:31960-34107:-1:exon
subclass of: SO_0000010

853667
type: Gene
SIO_000068: ncbigene

position:31960:-1
position: 31960
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:34107:-1
position: 34107
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31960-34107:-1:exon

YKL213C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UFD3
alternative label: ZZZ4
gene: DOA1
locus tag: YKL213C
gene synonym: UFD3; ZZZ4
product: Doa1p
transcript id: NM_001179778.1
SIO_010081: YKL213C
subclass of: SO_0000673
so part of: YKL213C
location: complement(<31960..>34107)
location: region:31960-34107:-1
so has part: feature:31960-34107:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31960-34107:-1:exon

YKL213C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UFD3
alternative label: ZZZ4
gene: DOA1
locus tag: YKL213C
gene synonym: UFD3; ZZZ4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16428438|PMID:21070969]
experiment: EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:23525333]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]
experiment: EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:18508771|PMID:19805280|PMID:7615550]
experiment: EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:20508643]
experiment: EXISTENCE:mutant phenotype:GO:0043130 ubiquitin binding [PMID:16428438]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:2111732|PMID:23525333]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579|PMID:21070972]
note: WD-repeat protein involved in Ub-mediated proteolysis; K48-, K29-specific Ub chain binding protein involved in Ub homeostasis; substrate-recruiting adaptor for Cdc48p in mitochondria-associated degradation; inhibits degradation of Ufd2p-dependent substrates; facilitates proteolysis of Cse4p, a centromeric H3-like protein; required for ribophagy; promotes NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon replication stress
codon start: 1
product: Doa1p
translation: MGYQLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWASEDEINELSTQVEKSTISSKTIEFDESKLSPYEILQSPGRKEGQIVVVKSPQGTIEAHQFSNSSWKKVGDVVGAGATGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNPYTAADNFLARYELPMSYRDQVVQFILKNTNGISLDQPNDNASSSAVSPSKTSVMKVLPVKQYLIMENYNPDTIFNGIVKINSNEKTFDDEILAQIGGALHDIDESWELLLSFANTIRSNWEIKTPAYDIVRLIVKKLPYSSDIKDYIEEGLGNKNITLTMLTVRILVNCFNNENWGVKLLESNQVYKSIFETIDTEFSQASAKQSQNLAIAVSTLIFNYSALVTKGNSDLELLPIVADAINTKYGPLEEYQECEEAAYRLTVAYGNLATVEPTLRQFANSVTWLANIKRSYGNVPRFKDIFDDLS
SIO_010081: YKL213C
subclass of: SO_0000673
so part of: YKL213C
location: complement(31960..34107)
location: region:31960-34107:-1
so has part: feature:31960-34107:-1:exon

NP_012709.1
type: Protein
SIO_000068: ncbiprotein

S000001696
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31960-34107:-1:exon

YKL212W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RSD1
gene: SAC1
locus tag: YKL212W
gene synonym: RSD1
so part of: sequence
location: <34543..>36414
location: region:34543-36414:1
so has part: feature:34543-36414:1:exon
subclass of: SO_0000010

853668
type: Gene
SIO_000068: ncbigene

position:34543:1
position: 34543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36414:1
position: 36414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34543-36414:1:exon

YKL212W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RSD1
gene: SAC1
locus tag: YKL212W
gene synonym: RSD1
product: phosphatidylinositol-3-phosphatase SAC1
transcript id: NM_001179777.1
SIO_010081: YKL212W
subclass of: SO_0000673
so part of: YKL212W
location: <34543..>36414
location: region:34543-36414:1
so has part: feature:34543-36414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34543-36414:1:exon

YKL212W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RSD1
gene: SAC1
locus tag: YKL212W
gene synonym: RSD1
EC number: 3.1.3.64
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15657391|PMID:8314848]
experiment: EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10625610]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11514624|PMID:15657391|PMID:8314848]
experiment: EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:22553352]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:30785834]
experiment: EXISTENCE:direct assay:GO:0035339 SPOTS complex [PMID:20182505]
experiment: EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10625610]
experiment: EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610]
experiment: EXISTENCE:direct assay:GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [PMID:10625610]
experiment: EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610]
experiment: EXISTENCE:mutant phenotype:GO:0000139 Golgi membrane [PMID:15657391]
experiment: EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:11514624|PMID:11792713|PMID:15657391]
experiment: EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610|PMID:22553352]
experiment: EXISTENCE:mutant phenotype:GO:0061909 autophagosome-lysosome fusion [PMID:32693712]
experiment: EXISTENCE:mutant phenotype:GO:0072517 host cell viral assembly compartment [PMID:32269127]
note: Phosphatidylinositol phosphate phosphatase; role in early and medial Golgi PtdIns4P hydrolysis; regulated by Vps74p interaction; ER localized transmembrane protein which cycles through the Golgi; role in protein trafficking, processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis by modulating PtdIns(4)P metabolism; PtdIns4P PPase activity is crucial for autophagosome-vacuole fusion during autophagy; human homolog SACM1L complements autophagy defects of the null
codon start: 1
product: phosphatidylinositol-3-phosphatase SAC1
translation: MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMGFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQKELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQFKGLKYAQSPKFSKPDPLKRD
SIO_010081: YKL212W
subclass of: SO_0000673
so part of: YKL212W
location: 34543..36414
location: region:34543-36414:1
so has part: feature:34543-36414:1:exon

NP_012710.1
type: Protein
SIO_000068: ncbiprotein

S000001695
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34543-36414:1:exon

YKL211C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRP3
locus tag: YKL211C
so part of: sequence
location: complement(<36699..>38153)
location: region:36699-38153:-1
so has part: feature:36699-38153:-1:exon
subclass of: SO_0000010

853669
type: Gene
SIO_000068: ncbigene

position:36699:-1
position: 36699
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38153:-1
position: 38153
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36699-38153:-1:exon

YKL211C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRP3
locus tag: YKL211C
product: bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
transcript id: NM_001179776.1
SIO_010081: YKL211C
subclass of: SO_0000673
so part of: YKL211C
location: complement(<36699..>38153)
location: region:36699-38153:-1
so has part: feature:36699-38153:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:36699-38153:-1:exon

YKL211C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRP3
locus tag: YKL211C
EC number: 4.1.1.48
EC number: 4.1.3.27
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004049 anthranilate synthase activity [PMID:3881257]
experiment: EXISTENCE:genetic interaction:GO:0004425 indole-3-glycerol-phosphate synthase activity [PMID:6323449]
experiment: EXISTENCE:mutant phenotype:GO:0000162 tryptophan biosynthetic process [PMID:10790693]
experiment: EXISTENCE:mutant phenotype:GO:0004425 indole-3-glycerol-phosphate synthase activity [PMID:3881257]
experiment: EXISTENCE:physical interaction:GO:0005950 anthranilate synthase complex [PMID:3881257]
note: Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
codon start: 1
product: bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase
translation: MSVHAATNPINKHVVLIDNYDSFTWNVYEYLCQEGAKVSVYRNDAITVPEIAALNPDTLLISPGPGHPKTDSGISRDCIRYFTGKIPVFGICMGQQCMFDVFGGEVAYAGEIVHGKTSPISHDNCGIFKNVPQGIAVTRYHSLAGTESSLPSCLKVTASTENGIIMGVRHKKYTVEGVQFHPESILTEEGHLMIRNILNVSGGTWEENKSSPSNSILDRIYARRKIDVNEQSKIPGFTFQDLQSNYDLGLAPPLQDFYTVLSSSHKRAVVLAEVKRASPSKGPICLKAVAAEQALKYAEAGASAISVLTEPHWFHGSLQDLVNVRKILDLKFPPKERPCVLRKEFIFSKYQILEARLAGADTVLLIVKMLSQPLLKELYSYSKDLNMEPLVEVNSKEELQRALEIGAKVVGVNNRDLHSFNVDLNTTSNLVESIPKDVLLIALSGITTRDDAEKYKKEGVHGFLVGEALMKSTDVKKFIHELCE
SIO_010081: YKL211C
subclass of: SO_0000673
so part of: YKL211C
location: complement(36699..38153)
location: region:36699-38153:-1
so has part: feature:36699-38153:-1:exon

NP_012711.1
type: Protein
SIO_000068: ncbiprotein

S000001694
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36699-38153:-1:exon

YNCK0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR64
locus tag: YNCK0001W
so part of: sequence
location: 38811..38911
location: region:38811-38911:1
so has part: feature:38811-38911:1:exon
subclass of: SO_0000578

9164917
type: Gene
SIO_000068: ncbigene

position:38811:1
position: 38811
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:38911:1
position: 38911
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38811-38911:1:exon

YNCK0001W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR64
locus tag: YNCK0001W
product: SNR64
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position C2337
transcript id: NR_132199.1
SIO_010081: YNCK0001W
subclass of: SO_0000673
so part of: YNCK0001W
location: 38811..38911
location: region:38811-38911:1
so has part: feature:38811-38911:1:exon

S000006455
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38811-38911:1:exon

YKL210W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBA1
locus tag: YKL210W
so part of: sequence
location: <39163..>42237
location: region:39163-42237:1
so has part: feature:39163-42237:1:exon
subclass of: SO_0000010

853670
type: Gene
SIO_000068: ncbigene

position:39163:1
position: 39163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42237:1
position: 42237
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:39163-42237:1:exon

YKL210W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBA1
locus tag: YKL210W
product: E1 ubiquitin-activating protein UBA1
transcript id: NM_001179775.1
SIO_010081: YKL210W
subclass of: SO_0000673
so part of: YKL210W
location: <39163..>42237
location: region:39163-42237:1
so has part: feature:39163-42237:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:39163-42237:1:exon

YKL210W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBA1
locus tag: YKL210W
EC number: 6.2.1.45
experiment: EXISTENCE:direct assay:GO:0004839 ubiquitin activating enzyme activity [PMID:1989885]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7629121|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7629121|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:1989885]
note: Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
codon start: 1
product: E1 ubiquitin-activating protein UBA1
translation: MSSNNSGLSAAGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEIAKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQKRGDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVATDTVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDEFTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGNFVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKKGGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQLHLGFQALHQFAVRHNGELPRTMNDEDANELIKLVTDLSVQQPEVLGEGVDVNEDLIKELSYQARGDIPGVVAFFGGLVAQEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKTTQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEMLKNWALLGLGSGSDGYIVVTDNDSIEKSNLNRQFLFRPKDVGKNKSEVAAEAVCAMNPDLKGKINAKIDKVGPETEEIFNDSFWESLDFVTNALDNVDARTYVDRRCVFYRKPLLESGTLGTKGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSGDVKGVLESISDSLSSKPHNFEDCIKWARLEFEKKFNHDIKQLLFNFPKDAKTSNGEPFWSGAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYKSVIDHMIIPEFTPNANLKIQVNDDDPDPNANAANGSDEIDQLVSSLPDPSTLAGFKLEPVDFEKDDDTNHHIEFITACSNCRAQNYFIETADRQKTKFIAGRIIPAIATTTSLVTGLVNLELYKLIDNKTDIEQYKNGFVNLALPFFGFSEPIASPKGEYNNKKYDKIWDRFDIKGDIKLSDLIEHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERLNLPITQLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVPFITIHL
SIO_010081: YKL210W
subclass of: SO_0000673
so part of: YKL210W
location: 39163..42237
location: region:39163-42237:1
so has part: feature:39163-42237:1:exon

NP_012712.1
type: Protein
SIO_000068: ncbiprotein

S000001693
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:39163-42237:1:exon

YKL209C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STE6
locus tag: YKL209C
so part of: sequence
location: complement(<42423..>46295)
location: region:42423-46295:-1
so has part: feature:42423-46295:-1:exon
subclass of: SO_0000010

853671
type: Gene
SIO_000068: ncbigene

position:42423:-1
position: 42423
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:46295:-1
position: 46295
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42423-46295:-1:exon

YKL209C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STE6
locus tag: YKL209C
product: ATP-binding cassette a-factor transporter STE6
transcript id: NM_001179774.1
SIO_010081: YKL209C
subclass of: SO_0000673
so part of: YKL209C
location: complement(<42423..>46295)
location: region:42423-46295:-1
so has part: feature:42423-46295:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42423-46295:-1:exon

YKL209C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STE6
locus tag: YKL209C
EC number: 7.4.2.7
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8045256]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7679674]
experiment: EXISTENCE:direct assay:GO:0015440 ABC-type peptide transporter activity [PMID:8626301|PMID:11389139]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:7679674|PMID:12374868]
experiment: EXISTENCE:mutant phenotype:GO:0000770 peptide pheromone export [PMID:2569166]
experiment: EXISTENCE:mutant phenotype:GO:0015440 ABC-type peptide transporter activity [PMID:8626301|PMID:11389139]
note: Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell
codon start: 1
product: ATP-binding cassette a-factor transporter STE6
translation: MNFLSFKTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGRVFDLLSVFVANGSHQGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTTLLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNRGELFQIVSNQSS
SIO_010081: YKL209C
subclass of: SO_0000673
so part of: YKL209C
location: complement(42423..46295)
location: region:42423-46295:-1
so has part: feature:42423-46295:-1:exon

NP_012713.1
type: Protein
SIO_000068: ncbiprotein

S000001692
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42423-46295:-1:exon

YNCK0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRT2
locus tag: YNCK0002C
so part of: sequence
location: complement(46735..46806)
location: region:46735-46806:-1
so has part: feature:46735-46806:-1:exon
subclass of: SO_0000663

853672
type: Gene
SIO_000068: ncbigene

position:46735:-1
position: 46735
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:46806:-1
position: 46806
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:46735-46806:-1:exon

YNCK0002C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: TRT2
locus tag: YNCK0002C
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis; correct folding and efficient aminoacylation require Lhp1p
SIO_010081: YNCK0002C
subclass of: SO_0000673
so part of: YNCK0002C
location: complement(46735..46806)
location: region:46735-46806:-1
so has part: feature:46735-46806:-1:exon

S000006748
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:46735-46806:-1:exon

YKL208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SOC1
gene: CBT1
locus tag: YKL208W
gene synonym: SOC1
so part of: sequence
location: <47157..>47972
location: region:47157-47972:1
so has part: feature:47157-47972:1:exon
subclass of: SO_0000010

853673
type: Gene
SIO_000068: ncbigene

position:47157:1
position: 47157
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:47972:1
position: 47972
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:47157-47972:1:exon

YKL208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SOC1
gene: CBT1
locus tag: YKL208W
gene synonym: SOC1
product: Cbt1p
transcript id: NM_001179773.1
SIO_010081: YKL208W
subclass of: SO_0000673
so part of: YKL208W
location: <47157..>47972
location: region:47157-47972:1
so has part: feature:47157-47972:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:47157-47972:1:exon

YKL208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SOC1
gene: CBT1
locus tag: YKL208W
gene synonym: SOC1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:9339340]
experiment: EXISTENCE:direct assay:GO:0017004 cytochrome complex assembly [PMID:9339340]
experiment: EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:16118200|PMID:9339340]
experiment: EXISTENCE:mutant phenotype:GO:0017004 cytochrome complex assembly [PMID:9339340]
experiment: EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:16118200]
note: Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
codon start: 1
product: Cbt1p
translation: MVSYGSHSSEVSKVLKTPKFVLRYGNVSSKQRFALKRKINYKLRESKYQEYLNEYNTFVLYDWENSGAGSLVDSSYNLPSLWKEFITEGISKGAINDKLPTVFMKRKLTNSALGHCLGLDFLTDPSESEHEYRCMFQTVQDIPSLSQLILFNSMPNVPVRLKLHTIGININFGCKRSLISNGGDQDTEMSEAVSYIQPLLEESSRMYRNLNYWKLLKIARNNKKDEPLDQSTRIKSQVKLLLSQLATNRITSPSVTDHGGHNWLIFTRRRL
SIO_010081: YKL208W
subclass of: SO_0000673
so part of: YKL208W
location: 47157..47972
location: region:47157-47972:1
so has part: feature:47157-47972:1:exon

NP_012714.1
type: Protein
SIO_000068: ncbiprotein

S000001691
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:47157-47972:1:exon

YKL207W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM27
gene: EMC3
locus tag: YKL207W
gene synonym: AIM27
so part of: sequence
location: <48194..>48955
location: region:48194-48955:1
so has part: feature:48194-48955:1:exon
subclass of: SO_0000010

853628
type: Gene
SIO_000068: ncbigene

position:48194:1
position: 48194
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48955:1
position: 48955
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48194-48955:1:exon

YKL207W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM27
gene: EMC3
locus tag: YKL207W
gene synonym: AIM27
product: Emc3p
transcript id: NM_001179772.1
SIO_010081: YKL207W
subclass of: SO_0000673
so part of: YKL207W
location: <48194..>48955
location: region:48194-48955:1
so has part: feature:48194-48955:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48194-48955:1:exon

YKL207W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM27
gene: EMC3
locus tag: YKL207W
gene synonym: AIM27
experiment: EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]
experiment: EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]
note: Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
codon start: 1
product: Emc3p
translation: MLLDDQLKYWVLLPISIVMVLTGVLKQYIMTLITGSSANEAQPRVKLTEWQYLQWAQLLIGNGGNLSSDAFAAKKEFLVKDLTEERHLAKAKQQDGSQAGEVPNPFNDPSMSNAMMNMAKGNMASFIPQTIIMWWVNHFFAGFILMQLPFPLTAKFKEMLQTGIICQDLDVRWVSSISWYFISVLGLNPVYNLIGLNDQDMGIQAGIGGPQGPQGPPQSQVDKAMHAMANDLTIIQHETCLDNVEQRVLKQYM
SIO_010081: YKL207W
subclass of: SO_0000673
so part of: YKL207W
location: 48194..48955
location: region:48194-48955:1
so has part: feature:48194-48955:1:exon

NP_012715.3
type: Protein
SIO_000068: ncbiprotein

S000001690
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48194-48955:1:exon

YKL206C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PBA2
alternative label: POC2
gene: ADD66
locus tag: YKL206C
gene synonym: PBA2; POC2
so part of: sequence
location: complement(<49006..>49809)
location: region:49006-49809:-1
so has part: feature:49006-49809:-1:exon
subclass of: SO_0000010

853629
type: Gene
SIO_000068: ncbigene

position:49006:-1
position: 49006
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:49809:-1
position: 49809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:49006-49809:-1:exon

YKL206C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PBA2
alternative label: POC2
gene: ADD66
locus tag: YKL206C
gene synonym: PBA2; POC2
product: Add66p
transcript id: NM_001179771.1
SIO_010081: YKL206C
subclass of: SO_0000673
so part of: YKL206C
location: complement(<49006..>49809)
location: region:49006-49809:-1
so has part: feature:49006-49809:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:49006-49809:-1:exon

YKL206C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PBA2
alternative label: POC2
gene: ADD66
locus tag: YKL206C
gene synonym: PBA2; POC2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17634286]
experiment: EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17431397]
experiment: EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:17634286]
note: Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
codon start: 1
product: Add66p
translation: MSCLVLPLVSVGNIPQLSIDWLLNSQANEWEYLEALDSKYLVEFVGPLDRPEDGSDSLYKDADMKYSSALEVFYNKKRGLFAIQQRTPLVSVNYLNNFIVEIILPFLSKYNISEICIWDSLYAMEDENGVIVRPQEVYSLGEFYFDDEAELLSNLHLNDQESMVNNWLHFTPTSFQDKISVDQPIFKILFQILNASQRPKALRSIKYCSCLANEGDNSLDSQQFLQWIISQKVIKNAPPIVKFVRPISWQGAYGMADARDKFVDLYN
SIO_010081: YKL206C
subclass of: SO_0000673
so part of: YKL206C
location: complement(49006..49809)
location: region:49006-49809:-1
so has part: feature:49006-49809:-1:exon

NP_012716.1
type: Protein
SIO_000068: ncbiprotein

S000001689
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:49006-49809:-1:exon

YKL205W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LOS1
locus tag: YKL205W
so part of: sequence
location: <50051..>53353
location: region:50051-53353:1
so has part: feature:50051-53353:1:exon
subclass of: SO_0000010

853630
type: Gene
SIO_000068: ncbigene

position:50051:1
position: 50051
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:53353:1
position: 53353
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:50051-53353:1:exon

YKL205W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LOS1
locus tag: YKL205W
product: Ran GTPase-binding protein LOS1
transcript id: NM_001179770.1
SIO_010081: YKL205W
subclass of: SO_0000673
so part of: YKL205W
location: <50051..>53353
location: region:50051-53353:1
so has part: feature:50051-53353:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:50051-53353:1:exon

YKL205W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LOS1
locus tag: YKL205W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18045534]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0016363 nuclear matrix [PMID:8366091]
experiment: EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:9774653]
experiment: EXISTENCE:genetic interaction:GO:0071528 tRNA re-export from nucleus [PMID:20032305]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:9802895]
note: Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction
codon start: 1
product: Ran GTPase-binding protein LOS1
translation: MLERIQQLVNAVNDPRSDVATKRQAIELLNGIKSSENALEIFISLVINENSNDLLKFYGLSTLIELMTEGVNANPNGLNLVKFEITKWLKFQVLGNKQTKLPDFLMNKISEVLTTLFMLMYSDCNGNQWNSFFDDLMSLFQVDSAISNTSPSTDGNILLGLEFFNKLCLMINSEIADQSFIRSKESQLKNNNIKDWMRDNDIMKLSNVWFQCLKLDEQIVSQCPGLINSTLDCIGSFISWIDINLIIDANNYYLQLIYKFLNLKETKISCYNCILAIISKKMKPMDKLAFLNMINLTNELTYYHQAISMNPQIITFDNLEVWESLTKLITSFGIEFTIIIEQVNDDQKLDTLYKQSVISNVDSILLEKIIPILLEFMNNEFDSITAKTFPFWSNYLAFLKKYKASSPNFVPLHKDFLDNFQQICFKRMKFSDDEVTQDDFEEFNETVRFKLKNFQEIIVVIDPSLFLNNISQEISANLMNCKNESWQIFELTIYQIFNLSECTKNNYFGLNKNEIMTSQPSLTLVRFLNELLMMKDFLLAIDNEQIQILFMELIVKNYNFIFSTSANTANATDDDEKYLLILNIFMSSFAMFNKRENVRLRSWYLFTRFLKLTRINLKKILFANKNLVNEITNKISPLLHIKVTSINAQGTDDNDTIFDNQLYIFEGIGFIITLNNSSQELTAATANTPIDYDILDQILTPLFTQLEGCITQGASPVVILECHHILMAIGTLARGLHIGLVPENQVNNMVVNKKLINDSLIHKFSNIAEVILVTFSFFNKFENIRDASRFTFARLIPILSNKILPFINKLIELILSSTDLKSWEMIDFLGFLSQLIHMFHTDTDCYQLFNQLLTPLINKVHSIIEEIDEQHDQQSSSNKPIDTAVTATSVNKNIVVTDSYRDKILLKKAYCTFLQSFTNNSVTSILLSDINRAILPVILNDLVTYTPQEIQETSMMKVSLNVLCNFIKCFGNGTCLDNDDINKDPNLKIDGLNEYFIMKCVPIIFEIPFNPIYKFNIKEGNFKTMAYDLARLLRELFIVSSNPTTNENECVKYLTQIYLPQIQLPQELTIQLVNMLTTMGQKQFEKWFVDNFISVLKQGQ
SIO_010081: YKL205W
subclass of: SO_0000673
so part of: YKL205W
location: 50051..53353
location: region:50051-53353:1
so has part: feature:50051-53353:1:exon

NP_012717.1
type: Protein
SIO_000068: ncbiprotein

S000001688
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:50051-53353:1:exon

YKL204W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EAP1
locus tag: YKL204W
so part of: sequence
location: <53704..>55602
location: region:53704-55602:1
so has part: feature:53704-55602:1:exon
subclass of: SO_0000010

853631
type: Gene
SIO_000068: ncbigene

position:53704:1
position: 53704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55602:1
position: 55602
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53704-55602:1:exon

YKL204W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EAP1
locus tag: YKL204W
product: Eap1p
transcript id: NM_001179769.1
SIO_010081: YKL204W
subclass of: SO_0000673
so part of: YKL204W
location: <53704..>55602
location: region:53704-55602:1
so has part: feature:53704-55602:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53704-55602:1:exon

YKL204W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EAP1
locus tag: YKL204W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:22890846]
experiment: EXISTENCE:direct assay:GO:0008190 eukaryotic initiation factor 4E binding [PMID:10848587]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:10848587]
experiment: EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:22890846]
experiment: EXISTENCE:mutant phenotype:GO:0006402 mRNA catabolic process [PMID:22890846]
experiment: EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:10848587]
note: eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
codon start: 1
product: Eap1p
translation: MELNDPSIISSSQFSGELSDSDTAAATHKSQQAISNLFQKLAKKGREEKPIGSVESSTDSSNISVATSGNNKESNKKKNKKTAMLNFSSLTDPITNYKPMDLQYKTYAYSMNELYHLKPSLASASYEEDPLISELVRSLPKRKFWRLRMGPPDQKHANNHHFNGNNGGGSWKAGYKNGKNDERRMSRTKNMQGGKRRSQQDDEEKKIDQEMLEMDKNLQLGGDVGHSIADFEDWKAKMKELELKKLSKSKGISNSTAIAPRESASHETPTDLRPVIPRGPSSITDFLNLKRQDKKEESSQQTPGIPVGQPSLSKTSIEQVNELETNSDLGKSSSSRFSSFFNKSATSLPSLDNNNQVPSSNVSVVNNDGNSTPHQSGSRLMSFFKESRSSTPNAESQLLSASDKDNGKMQTLPQFQQQPQQMQPMAFTQHPPNNNAFFNGLLNKGKSETSTPPPPPPGLIAHQGPQFPVMGVPPNFPQRMMPPPPGLVQFQKDSKDVNKKEDRQLRQNKNPNGTRNSKGKQEETATPDLPQQQYMPPPPPPGFFPMHPNFPNGPMPPLPQGFPIPPNGMLPVTGQQPQPPYPNMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLPPGLNSKKNIK
SIO_010081: YKL204W
subclass of: SO_0000673
so part of: YKL204W
location: 53704..55602
location: region:53704-55602:1
so has part: feature:53704-55602:1:exon

NP_012718.1
type: Protein
SIO_000068: ncbiprotein

S000001687
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53704-55602:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1103; Autonomously Replicating Sequence
so part of: sequence
location: 55671..55917
location: region:55671-55917:1
so has part: feature:55671-55917:1:region

S000118401
type: SGD
SIO_000068: sgd

position:55671:1
position: 55671
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:55917:1
position: 55917
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:55671-55917:1:region

YKL203C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DRR2
gene: TOR2
locus tag: YKL203C
gene synonym: DRR2
so part of: sequence
location: complement(<55935..>63359)
location: region:55935-63359:-1
so has part: feature:55935-63359:-1:exon
subclass of: SO_0000010

853632
type: Gene
SIO_000068: ncbigene

position:55935:-1
position: 55935
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:63359:-1
position: 63359
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:55935-63359:-1:exon

YKL203C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DRR2
gene: TOR2
locus tag: YKL203C
gene synonym: DRR2
product: phosphatidylinositol kinase-related protein kinase TOR2
transcript id: NM_001179768.1
SIO_010081: YKL203C
subclass of: SO_0000673
so part of: YKL203C
location: complement(<55935..>63359)
location: region:55935-63359:-1
so has part: feature:55935-63359:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:55935-63359:-1:exon

YKL203C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DRR2
gene: TOR2
locus tag: YKL203C
gene synonym: DRR2
EC number: 2.7.1.67
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:8846782]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:16055732|PMID:22307609]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10973982]
experiment: EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:9461583]
experiment: EXISTENCE:genetic interaction:GO:0035025 positive regulation of Rho protein signal transduction [PMID:9038344]
experiment: EXISTENCE:genetic interaction:GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity [PMID:9038344]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16055732]
experiment: EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9475724]
experiment: EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:12719473|PMID:8186460]
experiment: EXISTENCE:mutant phenotype:GO:0035025 positive regulation of Rho protein signal transduction [PMID:9038344]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:10198052]
experiment: EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]
experiment: EXISTENCE:mutant phenotype:GO:1905356 regulation of snRNA pseudouridine synthesis [PMID:27268497]
experiment: EXISTENCE:mutant phenotype:GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity [PMID:9038344]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12631735]
experiment: EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]
note: PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates plasma membrane (PM) homeostasis and cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; PM retention is dependent on Avo3p; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol kinase-related protein kinase TOR2
translation: MNKYINKYTTPPNLLSLRQRAEGKHRTRKKLTHKSHSHDDEMSTTSNTDSNHNGPNDSGRVITGSAGHIGKISFVDSELDTTFSTLNLIFDKLKSDVPQERASGANELSTTLTSLAREVSAEQFQRFSNSLNNKIFELIHGFTSSEKIGGILAVDTLISFYLSTEELPNQTSRLANYLRVLIPSSDIEVMRLAANTLGRLTVPGGTLTSDFVEFEVRTCIDWLTLTADNNSSSSKLEYRRHAALLIIKALADNSPYLLYPYVNSILDNIWVPLRDAKLIIRLDAAVALGKCLTIIQDRDPALGKQWFQRLFQGCTHGLSLNTNDSVHATLLVFRELLSLKAPYLRDKYDDIYKSTMKYKEYKFDVIRREVYAILPLLAAFDPAIFTKKYLDRIMVHYLRYLKNIDMNAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDNIREGLRTKFKVRKQFEKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNLLSISLSGEKFIQSNQYDFNNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQLIHHQYSLTEFVRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHSVSEVLSKLLMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPAYVVPSLRKTLLELLTQLKFSNMPKKKEESATLLCTLINSSDEVAKPYIDPILDVILPKCQDASSAVASTALKVLGELSVVGGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYVVGPLLDYPELLGILINILKTENNPHIRRGTVRLIGILGALDPYKHREIEVTSNSKSSVEQNAPSIDIALLMQGVSPSNDEYYPTVVIHNLMKILNDPSLSIHHTAAIQAIMHIFQNLGLRCVSFLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPIIKLQITIISVIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIMPIVVRMTEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSLLLLQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLNNECLPTNIIFDKENEVPERKNYEDEMQVTKLPVNQNILKNAWYCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCSSLVSVYYPLARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDDKPLPIPIHTLGKYAQKCHAFAKALHYKEVEFLEEPKNSTIEALISINNQLHQTDSAIGILKHAQQHNELQLKETWYEKLQRWEDALAAYNEKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWGTAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARDLLVTELSALVNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKNIDVWQRILRVRSLVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTLLEETDDPDHPNTAKASPPVVYAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLLARCFLKQGEWRVCLQPKWRLSNPDSILGSYLLATHFDNTWYKAWHNWALANFEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLDDASRQFFGEHNTEKMFAALEPLYEMLKR…
SIO_010081: YKL203C
subclass of: SO_0000673
so part of: YKL203C
location: complement(55935..63359)
location: region:55935-63359:-1
so has part: feature:55935-63359:-1:exon

NP_012719.2
type: Protein
SIO_000068: ncbiprotein

S000001686
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:55935-63359:-1:exon

YKL201C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKL200C
gene: MNN4
locus tag: YKL201C
gene synonym: YKL200C
so part of: sequence
location: complement(<63930..>67466)
location: region:63930-67466:-1
so has part: feature:63930-67466:-1:exon
subclass of: SO_0000010

853634
type: Gene
SIO_000068: ncbigene

position:63930:-1
position: 63930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:67466:-1
position: 67466
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:63930-67466:-1:exon

YKL201C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKL200C
gene: MNN4
locus tag: YKL201C
gene synonym: YKL200C
product: Mnn4p
transcript id: NM_001179766.1
SIO_010081: YKL201C
subclass of: SO_0000673
so part of: YKL201C
location: complement(<63930..>67466)
location: region:63930-67466:-1
so has part: feature:63930-67466:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:63930-67466:-1:exon

YKL201C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKL200C
gene: MNN4
locus tag: YKL201C
gene synonym: YKL200C
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:30842360]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9023541]
experiment: EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:9813355]
experiment: EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:9459307]
note: Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; may also function as a mannosylphosphate transferase; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
codon start: 1
product: Mnn4p
translation: MLQRISSKLHRRFLSGLLRVKHYPLRRILLPLILLQIIIITFIWSNSPQRNGLGRDADYLLPNYNELDSDDDSWYSILTSSFKNDRKIQFAKTLYENLKFGTNPKWVNEYTLQNDLLSVKMGPRKGSKLESVDELKFYDFDPRLTWSVVLNHLQNNDADQPEKLPFSWYDWTTFHELNKLISIDKTVLPCNFLFQSAFDKESLEAIETELGEPLFLYERPKYAQKLWYKAARNQDRIKDSKELKKHCSKLFTPDGHGSPKGLRFNTQFQIKELYDKVRPEVYQLQARNYILTTQSHPLSISIIESDNSTYQVPLQTEKSKNLVQSGLLQEYINDNINSTNKRKKNKQDVEFNHNRLFQEFVNNDQVNSLYKLEIEETDKFTFDKDLVYLSPSDFKFDASKKIEELEEQKKLYPDKFSAHNENYLNSLKNSVKTSPALQRKFFYEAGAVKQYKGMGFHRDKRFFNVDTLINDKQEYQARLNSMIRTFQKFTKANGIISWLSHGTLYGYLYNGMAFPWDNDFDLQMPIKHLQLLSQYFNQSLILEDPRQGNGRYFLDVSDSLTVRINGNGKNNIDARFIDVDTGLYIDITGLASTSAPSRDYLNSYIEERLQEEHLDINNIPESNGETATLPDKVDDGLVNMATLNITELRDYITSDENKNHKRVPTDTDLKDLLKKELEELPKSKTIENKLNPKQRYFLNEKLKLYNCRNNHFNSFEELSPLINTVFHGVPALIPHRHTYCLHNEYHVPDRYAFDAYKNTAYLPEFRFWFDYDGLKKCSNINSWYPNIPSINSWNPNLLKEISSTKFESKLFDSNKVSEYSFKNLSMDDVRLIYKNIPKAGFIEVFTNLYNSFNVTAYRQKELEIQYCQNLTFIEKKKLLHQLRINVAPKLSSPAKDPFLFGYEKAMWKDLSKSMNQTTLDQVTKIVHEEYVGKIIDLSESLKYRNFSLFNITFDETGTTLDDNTEDYTPANTVEVNPVDFKSNLNFSSNSFLDLNSYGLDLFAPTLSDVNRKGIQMFDKDPIIVYEDYAYAKLLEERKRREKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKKQEEKNKKNEDEEKKKQEEEEKKKNEEEEKKKQEEGHSN
SIO_010081: YKL201C
subclass of: SO_0000673
so part of: YKL201C
location: complement(63930..67466)
location: region:63930-67466:-1
so has part: feature:63930-67466:-1:exon

NP_012721.1
type: Protein
SIO_000068: ncbiprotein

S000001684
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:63930-67466:-1:exon

YKL198C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KKT8
alternative label: POT1
alternative label: STK1
alternative label: YKL199C
alternative label: YKT9
gene: PTK1
locus tag: YKL198C
gene synonym: KKT8; POT1; STK1; YKL199C; YKT9
so part of: sequence
location: complement(<68232..>70220)
location: region:68232-70220:-1
so has part: feature:68232-70220:-1:exon
subclass of: SO_0000010

853635
type: Gene
SIO_000068: ncbigene

position:68232:-1
position: 68232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70220:-1
position: 70220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:68232-70220:-1:exon

YKL198C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KKT8
alternative label: POT1
alternative label: STK1
alternative label: YKL199C
alternative label: YKT9
gene: PTK1
locus tag: YKL198C
gene synonym: KKT8; POT1; STK1; YKL199C; YKT9
product: putative serine/threonine protein kinase PTK1
transcript id: NM_001179764.2
SIO_010081: YKL198C
subclass of: SO_0000673
so part of: YKL198C
location: complement(<68232..>70220)
location: region:68232-70220:-1
so has part: feature:68232-70220:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:68232-70220:-1:exon

YKL198C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KKT8
alternative label: POT1
alternative label: STK1
alternative label: YKL199C
alternative label: YKT9
gene: PTK1
locus tag: YKL198C
gene synonym: KKT8; POT1; STK1; YKL199C; YKT9
EC number: 2.7.11.1
experiment: EXISTENCE:genetic interaction:GO:0000296 spermine transport [PMID:7488221]
note: Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication
codon start: 1
product: putative serine/threonine protein kinase PTK1
translation: MTVSHNHSTKISQQPISSVSAFKFFGKKLLSSSHGNKLKKKASLPPDFHSTSTNDSESSSPKLPNSLKTSRRANSFAHTTNSKRSLSSASTKILPPAGSSTSISRGNRHSSTSRNLSNSKFSSERLVYNPYGVSTPSTSLSSVSTSMKKDPDLGFYLHDGDSKIRMLPIPIVDPNEYLPDEMKEASIQLSDNFVFDDENKTIGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYKRCSKEFIIAKQLSHHVHITNTFLLVKVPTTVYTTRGWGFVMELGLRDLFAMIQKSGWRSVALAEKFCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPFLESCSFDTGFRDYCDAYENFIRLHDRAFRNRGNYRPGPGMEYHLARNFKNGHASRVAWRLADPEAATRYTIDDLFEDPWFQGIETCVDANDKYVCKKPIIKTTTYENPRGFHIATDVAATTPTSNPFLKNRVPIRSMVDIAAHPSPTATVLASSPPPPPPATHVPAEALFTLRETPPPQLATLTLSEEPPATPAPSAPSAPSARVRGHSPHRVVHHHLNIVNSLVHSSSAASSQVPAST
SIO_010081: YKL198C
subclass of: SO_0000673
so part of: YKL198C
location: complement(68232..70220)
location: region:68232-70220:-1
so has part: feature:68232-70220:-1:exon

NP_012723.3
type: Protein
SIO_000068: ncbiprotein

S000001681
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:68232-70220:-1:exon

YKL197C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAS1
gene: PEX1
locus tag: YKL197C
gene synonym: PAS1
so part of: sequence
location: complement(<70734..>73865)
location: region:70734-73865:-1
so has part: feature:70734-73865:-1:exon
subclass of: SO_0000010

853636
type: Gene
SIO_000068: ncbigene

position:70734:-1
position: 70734
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73865:-1
position: 73865
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70734-73865:-1:exon

YKL197C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAS1
gene: PEX1
locus tag: YKL197C
gene synonym: PAS1
product: AAA family ATPase peroxin 1
transcript id: NM_001179763.1
SIO_010081: YKL197C
subclass of: SO_0000673
so part of: YKL197C
location: complement(<70734..>73865)
location: region:70734-73865:-1
so has part: feature:70734-73865:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70734-73865:-1:exon

YKL197C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAS1
gene: PEX1
locus tag: YKL197C
gene synonym: PAS1
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:16911527]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:29321502]
experiment: EXISTENCE:genetic interaction:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:15634331]
note: AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; mutations in human PEX1 can lead to severe peroxisomal disorders and early death
codon start: 1
product: AAA family ATPase peroxin 1
translation: MTTTKRLKFENLRIQFSNAIVGNFLRLPHSIINVLESTNYAIQEFGIAVHSHNSDIPIVHLGWDGHDSGSSENVVLINPVLATVYDLNQKSPLVDLYIQRYDHTHLATEVYVTPETSDDWEIIDANAMRFQNGEILHQTRIVTPGETLICYLEGIVTKFKIDRVEPSMKSARITDGSLVVVAPKVNKTRLVKAEYGHSNKTILKNGAIQLLKKVILRSTVCKMDFPKDNLFVVYISDGAQLPSQKGYASIVKCSLRQSKKSDSDNKSVGIPSKKIGVFIKCDSQIPENHIALSSHLWDAFFTHPMNGAKIKLEFLQMNQANIISGRNATVNIKYFGKDVPTKSGDQYSKLLGGSLLTNNLILPTEQIIIEIKKGESEQQLCNLNEISNESVQWKVTQMGKEEVKDIIERHLPKHYHVKETGEVSRTSKDEDDFITVNSIKKEMVNYLTSPIIATPAIILDGKQGIGKTRLLKELINEVEKDHHIFVKYADCETLHETSNLDKTQKLIMEWCSFCYWYGPSLIVLDNVEALFGKPQANDGDPSNNGQWDNASKLLNFFINQVTKIFNKDNKRIRVLFSGKQKTQINPLLFDKHFVSETWSLRAPDKHARAKLLEYFFSKNQIMKLNRDLQFSDLSLETEGFSPLDLEIFTEKIFYDLQLERDCDNVVTRELFSKSLSAFTPSALRGVKLTKETNIKWGDIGALANAKDVLLETLEWPTKYEPIFVNCPLRLRSGILLYGYPGCGKTLLASAVAQQCGLNFISVKGPEILNKFIGASEQNIRELFERAQSVKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLDGVYILAATSRPDLIDSALLRPGRLDKSVICNIPTESERLDILQAIVNSKDKDTGQKKFALEKNADLKLIAEKTAGFSGADLQGLCYNAYLKSVHRWLSAADQSEVVPGNDNIEYFSINEHGRREENRLRLKTLLQQDVVHETKTSTSAASELTAVVTINDLLEACQETKPSISTSELVKLRGIYDRFQKDRNGEMPNGENSIDIGSRLSLM
SIO_010081: YKL197C
subclass of: SO_0000673
so part of: YKL197C
location: complement(70734..73865)
location: region:70734-73865:-1
so has part: feature:70734-73865:-1:exon

NP_012724.1
type: Protein
SIO_000068: ncbiprotein

S000001680
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70734-73865:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 74236..74518
location: region:74236-74518:1
so has part: feature:74236-74518:1:region

S000007055
type: SGD
SIO_000068: sgd

position:74236:1
position: 74236
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:74518:1
position: 74518
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74236-74518:1:region

YNCK0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0003W
so part of: sequence
location: 74624..74697
location: region:74624-74697:1
so has part: feature:74624-74697:1:exon
subclass of: SO_0000663

853637
type: Gene
SIO_000068: ncbigene

position:74624:1
position: 74624
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:74697:1
position: 74697
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74624-74697:1:exon

YNCK0003W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0003W
product: tRNA-Asn
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Asparagine tRNA (tRNA-Asn), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0003W
subclass of: SO_0000673
so part of: YNCK0003W
location: 74624..74697
location: region:74624-74697:1
so has part: feature:74624-74697:1:exon

S000006671
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74624-74697:1:exon

YKL196C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YKT6
locus tag: YKL196C
so part of: sequence
location: complement(<74932..>75534)
location: region:74932-75534:-1
so has part: feature:74932-75534:-1:exon
subclass of: SO_0000010

853638
type: Gene
SIO_000068: ncbigene

position:74932:-1
position: 74932
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:75534:-1
position: 75534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74932-75534:-1:exon

YKL196C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YKT6
locus tag: YKL196C
product: palmitoyltransferase YKT6
transcript id: NM_001179762.1
SIO_010081: YKL196C
subclass of: SO_0000673
so part of: YKL196C
location: complement(<74932..>75534)
location: region:74932-75534:-1
so has part: feature:74932-75534:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74932-75534:-1:exon

YKL196C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YKT6
locus tag: YKL196C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15723044]
experiment: EXISTENCE:direct assay:GO:0000421 autophagosome membrane [PMID:33025734]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998|PMID:33025734]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:18541004]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18541004]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:9211930]
experiment: EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:14685280]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0061909 autophagosome-lysosome fusion [PMID:33025734]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9211930]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:10591633]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10385523]
note: Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within Golgi, endocytic trafficking to vacuole, and vacuolar fusion; membrane localization due to prenylation at carboxy-terminus; targeted to vacuole via AP-3 pathway; human homolog YKT6 can complement yeast ykt6 mutant
codon start: 1
product: palmitoyltransferase YKT6
translation: MRIYYIGVFRSGGEKALELSEVKDLSQFGFFERSSVGQFMTFFAETVASRTGAGQRQSIEEGNYIGHVYARSEGICGVLITDKEYPVRPAYTLLNKILDEYLVAHPKEEWADVTETNDALKMKQLDTYISKYQDPSQADAIMKVQQELDETKIVLHKTIENVLQRGEKLDNLVDKSESLTASSKMFYKQAKKSNSCCIIM
SIO_010081: YKL196C
subclass of: SO_0000673
so part of: YKL196C
location: complement(74932..75534)
location: region:74932-75534:-1
so has part: feature:74932-75534:-1:exon

NP_012725.1
type: Protein
SIO_000068: ncbiprotein

S000001679
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74932-75534:-1:exon

YKL195W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP15
alternative label: TIM40
gene: MIA40
locus tag: YKL195W
gene synonym: FMP15; TIM40
so part of: sequence
location: <75821..>77032
location: region:75821-77032:1
so has part: feature:75821-77032:1:exon
subclass of: SO_0000010

853639
type: Gene
SIO_000068: ncbigene

position:75821:1
position: 75821
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77032:1
position: 77032
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:75821-77032:1:exon

YKL195W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP15
alternative label: TIM40
gene: MIA40
locus tag: YKL195W
gene synonym: FMP15; TIM40
product: Mia40p
transcript id: NM_001179761.1
SIO_010081: YKL195W
subclass of: SO_0000673
so part of: YKL195W
location: <75821..>77032
location: region:75821-77032:1
so has part: feature:75821-77032:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:75821-77032:1:exon

YKL195W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP15
alternative label: TIM40
gene: MIA40
locus tag: YKL195W
gene synonym: FMP15; TIM40
experiment: EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:25451030]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:14690591|PMID:24769239|P MID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15364952|PMID:15620710]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:15359280]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:22990235|PMID:25451030]
experiment: EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:25451030]
experiment: EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:23834247]
experiment: EXISTENCE:mutant phenotype:GO:0016491 oxidoreductase activity [PMID:22990235]
experiment: EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15359280|PMID:15364952|PMID:17336303|PMID:27343349]
experiment: EXISTENCE:physical interaction:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15989955]
note: Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro
codon start: 1
product: Mia40p
translation: MLRNLVVRNACRNRPSIQVARGLCRHQTRRLMASSPQFGRNSNQEKTAGFIMGILSMAGALYFIAPNRKPLFASRKVESDKTAEEELSSGGEQSPENEDDNNSKSDENGDDNDSKNDETEAGPQLGGDKIGASKVAEDGELVVLAEEDNKSSEDKDTDESKVSTKDDEQSNEDNATANNQKDENISSENSEENTSDKTLDNNAGSSEKKDPEHSDDEKSQQGQSDDKTTTEDNNGEEESSKKTVSDSENSAKQSESSDEEKEELRKQEEKQMGPTEEEVQHEGAYNPDTGEINWDCPCLGGMAHGPCGEEFKSAFSCFVYSEAEPKGIDCVEKFQHMQDCFRKYPEHYAEQLKETSDDEEPQDKVKVNTIESAPNVSSAKENAAKKAEQSDVKKEPLNEESKP
SIO_010081: YKL195W
subclass of: SO_0000673
so part of: YKL195W
location: 75821..77032
location: region:75821-77032:1
so has part: feature:75821-77032:1:exon

NP_012726.2
type: Protein
SIO_000068: ncbiprotein

S000001678
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:75821-77032:1:exon

YKL194C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MST1
locus tag: YKL194C
so part of: sequence
location: complement(<77258..>78646)
location: region:77258-78646:-1
so has part: feature:77258-78646:-1:exon
subclass of: SO_0000010

853640
type: Gene
SIO_000068: ncbigene

position:77258:-1
position: 77258
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:78646:-1
position: 78646
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77258-78646:-1:exon

YKL194C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MST1
locus tag: YKL194C
product: threonine--tRNA ligase MST1
transcript id: NM_001179760.1
SIO_010081: YKL194C
subclass of: SO_0000673
so part of: YKL194C
location: complement(<77258..>78646)
location: region:77258-78646:-1
so has part: feature:77258-78646:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77258-78646:-1:exon

YKL194C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MST1
locus tag: YKL194C
EC number: 6.1.1.3
experiment: EXISTENCE:direct assay:GO:0004829 threonine-tRNA ligase activity [PMID:21321019]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2999113|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0070159 mitochondrial threonyl-tRNA aminoacylation [PMID:21321019]
experiment: EXISTENCE:mutant phenotype:GO:0004829 threonine-tRNA ligase activity [PMID:2999113]
note: Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr
codon start: 1
product: threonine--tRNA ligase MST1
translation: MKIQLVRWHCSRNALWNRAFYSTRKATKNASSATPATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVETTDEEKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASGALSGLTRLRKFHQDDGHIFCTPSQVKSEIFNSLKLIDIVYNKIFPFVKGGSGAESNYFINFSTRPDHFIGDLKVWNHAEQVLKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTHQVATIQLDFQLPERFDLKFKDQDNSYKRPIMIHRATFGSIERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMCTALQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYRIKSAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKLTMSQIWEKFIELEKNYK
SIO_010081: YKL194C
subclass of: SO_0000673
so part of: YKL194C
location: complement(77258..78646)
location: region:77258-78646:-1
so has part: feature:77258-78646:-1:exon

NP_012727.1
type: Protein
SIO_000068: ncbiprotein

S000001677
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77258-78646:-1:exon

YKL193C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EGP1
gene: SDS22
locus tag: YKL193C
gene synonym: EGP1
so part of: sequence
location: complement(<78866..>79882)
location: region:78866-79882:-1
so has part: feature:78866-79882:-1:exon
subclass of: SO_0000010

853641
type: Gene
SIO_000068: ncbigene

position:78866:-1
position: 78866
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79882:-1
position: 79882
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78866-79882:-1:exon

YKL193C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EGP1
gene: SDS22
locus tag: YKL193C
gene synonym: EGP1
product: type 1 protein phosphatase-activating protein SDS22
transcript id: NM_001179759.1
SIO_010081: YKL193C
subclass of: SO_0000673
so part of: YKL193C
location: complement(<78866..>79882)
location: region:78866-79882:-1
so has part: feature:78866-79882:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78866-79882:-1:exon

YKL193C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EGP1
gene: SDS22
locus tag: YKL193C
gene synonym: EGP1
experiment: EXISTENCE:direct assay:GO:0000164 protein phosphatase type 1 complex [PMID:10775415]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11801737|PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:17142459]
experiment: EXISTENCE:genetic interaction:GO:0072542 protein phosphatase activator activity [PMID:11801737|PMID:18172024]
experiment: EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:17142459]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11801737]
experiment: EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:11801737]
note: Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
codon start: 1
product: type 1 protein phosphatase-activating protein SDS22
translation: MDKNSVNKDSEEKDERHKIEVVDDTNPDFITADSELTQDLPDDVEVIDLVHLKIKSLEDLNLYRFKNLKQLCLRQNLIESISEVEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLINLHPLKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFITKIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPIQLENKTSYRRKLTMNLPPSLQKIDATYIRG
SIO_010081: YKL193C
subclass of: SO_0000673
so part of: YKL193C
location: complement(78866..79882)
location: region:78866-79882:-1
so has part: feature:78866-79882:-1:exon

NP_012728.1
type: Protein
SIO_000068: ncbiprotein

S000001676
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78866-79882:-1:exon

YKL192C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACP1
locus tag: YKL192C
so part of: sequence
location: complement(<80160..>80537)
location: region:80160-80537:-1
so has part: feature:80160-80537:-1:exon
subclass of: SO_0000010

853642
type: Gene
SIO_000068: ncbigene

position:80160:-1
position: 80160
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80537:-1
position: 80537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80160-80537:-1:exon

YKL192C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACP1
locus tag: YKL192C
product: acyl carrier protein
transcript id: NM_001179758.1
SIO_010081: YKL192C
subclass of: SO_0000673
so part of: YKL192C
location: complement(<80160..>80537)
location: region:80160-80537:-1
so has part: feature:80160-80537:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80160-80537:-1:exon

YKL192C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACP1
locus tag: YKL192C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0009107 lipoate biosynthetic process [PMID:9187370]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:27540631]
experiment: EXISTENCE:physical interaction:GO:0099128 mitochondrial iron-sulfur cluster assembly complex [PMID:27540631]
note: Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; coordinates mitochondrial fatty acid and iron sulfur cluster metabolism; activated by phosphopantetheinylation catalyzed by Ppt2p
codon start: 1
product: acyl carrier protein
translation: MFRSVCRISSRVAPSAYRTIMGRSVMSNTILAQRFYSANLSKDQVSQRVIDVIKAFDKNSPNIANKQISSDTQFHKDLGLDSLDTVELLVAIEEEFDIEIPDKVADELRSVGETVDYIASNPDAN
SIO_010081: YKL192C
subclass of: SO_0000673
so part of: YKL192C
location: complement(80160..80537)
location: region:80160-80537:-1
so has part: feature:80160-80537:-1:exon

NP_012729.1
type: Protein
SIO_000068: ncbiprotein

S000001675
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80160-80537:-1:exon

YKL191W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPH2
locus tag: YKL191W
so part of: sequence
location: <81035..>82639
location: region:81035-82639:1
so has part: feature:81035-82639:1:exon
subclass of: SO_0000010

853643
type: Gene
SIO_000068: ncbigene

position:81035:1
position: 81035
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82639:1
position: 82639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81035-82639:1:exon

YKL191W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPH2
locus tag: YKL191W
product: 2-(3-amino-3-carboxypropyl)histidine synthase
transcript id: NM_001179757.1
SIO_010081: YKL191W
subclass of: SO_0000673
so part of: YKL191W
location: <81035..>82639
location: region:81035-82639:1
so has part: feature:81035-82639:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81035-82639:1:exon

YKL191W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPH2
locus tag: YKL191W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [PMID:8406038|PMID:15485916]
note: Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph1p that catalyzes the first step of diphthamide biosynthesis
codon start: 1
product: 2-(3-amino-3-carboxypropyl)histidine synthase
translation: MEVAPALSTTQSDVAFQKVETHEIDRSSYLGPCYNSDELMQLISAYYNVEPLVGYLEQHPEYQNVTLQFPDDLIKDSSLIVRLLQSKFPHGKIKFWVLADTAYSACCVDEVAAEHVHAEVVVHFGDACLNAIQNLPVVYSFGTPFLDLALVVENFQRAFPDLSSKICLMANAPFSKHLSQLYNILKGDLHYTNIIYSQVNTSAVEEKFVTILDTFHVPEDVDQVGVFEKNSVLFGQHDKADNISPEDYHLFHLTTPQDPRLLYLSTVFQSVHIFDPALPGMVTGPFPSLMRRYKYMHVARTAGCIGILVNTLSLRNTRETINELVKLIKTREKKHYLFVVGKPNVAKLANFEDIDIWCILGCSQSGIIVDQFNEFYKPIITPYELNLALSEEVTWTGKWVVDFRDAIDEIEQNLGGQDTISASTTSDEPEFDVVRGRYTSTSRPLRALTHLELEAADDDDSKQLTTRHTASGAVIKGTVSTSASALQNRSWKGLGSDFDSTEVDNTGADIEEGISGVARGYGFDREDAMKKENK
SIO_010081: YKL191W
subclass of: SO_0000673
so part of: YKL191W
location: 81035..82639
location: region:81035-82639:1
so has part: feature:81035-82639:1:exon

NP_012730.1
type: Protein
SIO_000068: ncbiprotein

S000001674
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81035-82639:1:exon

YKL190W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CRV1
alternative label: YCN2
gene: CNB1
locus tag: YKL190W
gene synonym: CRV1; YCN2
so part of: sequence
location: <82947..>83550
location: region:82947-83550:1
so has part: feature:82947-83550:1:exon
subclass of: SO_0000010

853644
type: Gene
SIO_000068: ncbigene

position:82947:1
position: 82947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:83550:1
position: 83550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:82947-83550:1:exon

YKL190W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CRV1
alternative label: YCN2
gene: CNB1
locus tag: YKL190W
gene synonym: CRV1; YCN2
product: calcineurin regulatory subunit B
transcript id: NM_001179756.1
SIO_010081: YKL190W
subclass of: SO_0000673
so part of: YKL190W
location: join(<82947..82998,83075..>83550)
location: region:82947-83550:1
so has part: feature:82947-82998:1:exon
so has part: feature:83075-83550:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:82947-82998:1:exon

position:82998:1
position: 82998
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:83075-83550:1:exon

position:83075:1
position: 83075
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL190W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CRV1
alternative label: YCN2
gene: CNB1
locus tag: YKL190W
gene synonym: CRV1; YCN2
experiment: EXISTENCE:direct assay:GO:0004723 calcium-dependent protein serine/threonine phosphatase activity [PMID:1321337]
experiment: EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:1321337]
experiment: EXISTENCE:direct assay:GO:0005955 calcineurin complex [PMID:1321337]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:1321337]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:8798496]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7530227]
note: Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress
codon start: 1
product: calcineurin regulatory subunit B
translation: MGAAPSKIVDGLLEDTNFDRDEIERLRKRFMKLDRDSSGSIDKNEFMSIPGVSSNPLAGRIMEVFDADNSGDVDFQEFITGLSIFSGRGSKDEKLRFAFKIYDIDKDGFISNGELFIVLKIMVGSNLDDEQLQQIVDRTIVENDSDGDGRLSFEEFKNAIETTEVAKSLTLQYDV
SIO_010081: YKL190W
subclass of: SO_0000673
so part of: YKL190W
location: join(82947..82998,83075..83550)
location: region:82947-83550:1
so has part: feature:82947-82998:1:exon
so has part: feature:83075-83550:1:exon

NP_012731.1
type: Protein
SIO_000068: ncbiprotein

S000001673
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:82947-82998:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:83075-83550:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(83808..84115)
location: region:83808-84115:-1
so has part: feature:83808-84115:-1:region

S000007050
type: SGD
SIO_000068: sgd

position:83808:-1
position: 83808
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:84115:-1
position: 84115
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:83808-84115:-1:region

YNCK0004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0004W
so part of: sequence
location: 84208..84291
location: region:84208-84291:1
so has part: feature:84208-84291:1:exon
subclass of: SO_0000663

853645
type: Gene
SIO_000068: ncbigene

position:84208:1
position: 84208
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:84291:1
position: 84291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84208-84291:1:exon

YNCK0004W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0004W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0004W
subclass of: SO_0000673
so part of: YNCK0004W
location: 84208..84291
location: region:84208-84291:1
so has part: feature:84208-84291:1:exon

S000006651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84208-84291:1:exon

YKL189W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HYM1
locus tag: YKL189W
so part of: sequence
location: <84704..>85903
location: region:84704-85903:1
so has part: feature:84704-85903:1:exon
subclass of: SO_0000010

853646
type: Gene
SIO_000068: ncbigene

position:84704:1
position: 84704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85903:1
position: 85903
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84704-85903:1:exon

YKL189W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HYM1
locus tag: YKL189W
product: Hym1p
transcript id: NM_001179755.1
SIO_010081: YKL189W
subclass of: SO_0000673
so part of: YKL189W
location: <84704..>85903
location: region:84704-85903:1
so has part: feature:84704-85903:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84704-85903:1:exon

YKL189W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HYM1
locus tag: YKL189W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12972564]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11259593]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:12972564]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]
note: Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis; interacts with Sog2p; allosterically activates Kic1p; localizes to sites of polarized growth during budding and during the mating response
codon start: 1
product: Hym1p
translation: MFKKYKNQDLDMAFWWKKNPKTPSDYARLIIEQLNKFSSPSLTQDNKRKVQEECTKYLIGTKHFIVGDTDPHPTPEAIDELYTAMHRADVFYELLLHFVDLEFEARRECMLIFSICLGYSKDNKFVTVDYLVSQPKTISLMLRTAEVALQQKGCQDIFLTVGNMIIECIKYEQLCRIILKDPQLWKFFEFAKLGNFEISTESLQILSAAFTAHPKLVSKEFFSNEINIIRFIKCINKLMAHGSYVTKRQSTKLLASLIVIRSNNALMNIYINSPENLKLIMTLMTDKSKNLQLEAFNVFKVMVANPRKSKPVFDILVKNRDKLLTYFKTFGLDSQDSTFLDEREFIVQEIDSLPRIISSTTEVSNNNASSSNVASITSPSSVMNNQSSILTHSTSPDSR
SIO_010081: YKL189W
subclass of: SO_0000673
so part of: YKL189W
location: 84704..85903
location: region:84704-85903:1
so has part: feature:84704-85903:1:exon

NP_012732.1
type: Protein
SIO_000068: ncbiprotein

S000001672
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84704-85903:1:exon

YKL188C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAT1
gene: PXA2
locus tag: YKL188C
gene synonym: PAT1
so part of: sequence
location: complement(<86225..>88786)
location: region:86225-88786:-1
so has part: feature:86225-88786:-1:exon
subclass of: SO_0000010

853647
type: Gene
SIO_000068: ncbigene

position:86225:-1
position: 86225
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:88786:-1
position: 88786
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86225-88786:-1:exon

YKL188C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAT1
gene: PXA2
locus tag: YKL188C
gene synonym: PAT1
product: ATP-binding cassette long-chain fatty acid transporter PXA2
transcript id: NM_001179754.1
SIO_010081: YKL188C
subclass of: SO_0000673
so part of: YKL188C
location: complement(<86225..>88786)
location: region:86225-88786:-1
so has part: feature:86225-88786:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:86225-88786:-1:exon

YKL188C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAT1
gene: PXA2
locus tag: YKL188C
gene synonym: PAT1
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9395310|PMID:35127709]
experiment: EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:35127709]
experiment: EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:9395310|PMID:35127709]
experiment: EXISTENCE:direct assay:GO:1902001 fatty acid transmembrane transport [PMID:9395310]
note: Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant
codon start: 1
product: ATP-binding cassette long-chain fatty acid transporter PXA2
translation: MISTASAFYQKHRVNLLRSSYIILLLATLYNSNSSSSNNKTDKKDSESTVLENKKIEEGKETAVDREEDESSKEELTIVSKHSTDSEDGAIIIDKESKTNHKGGERKGKVDFLFKLLLHDKKCLILFITQAILLNIRTLLSLRVATLDGQLVSTLVRAQYANFTKILLGKWMILGIPASFINSLISYTTKLCAVTINRKVSDFLLSKYLSNHHTFYSVASAESVSEIQDNLTKDIYTFSMNSSLLLNQLLKPMLDLILCSFKLLTSNTSVMGEGTLALGLIVYASNSLLKLIQPNFTRLTMASASLESWFRSLHSNLHSSNEEIALLRGQKRELENVDYSFYRLVLFLNREIKARAIYDVATAFVIKYTWGAAGLVLCSIPIFFKNKPSEDTLQLKEPGNDMTADFITNRRLLVTASSSIGRFVELKRNIQQLRGIRLRLNKFNDLLDANKGDDEKEPRDERCIVEYDDSRIKFENIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSLFRILGGLWPIRATPNKNHQSKLIMPRRTVDRDCAIFYLPQRPYMGNRSTFREQIIYPDSIEQFKERYHNDYDLGDADLIKILQLLDLEDLVTENMSLLLAQRTSKNDSQQLSTEDNQSPCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYYHKPKFAVLDECTSAVAPEMEQRMYENAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQFGPFNPKERLCNEEKLLELNAILDQQVPLWERKLKDLTIAKESNIIRKSETNLNLFEKIEDPKTSKSNALFNANKGQRITSPTGQETSKRLPLFSQPSSSASSNLLRNNKSLNKKVKTKKEEGKER
SIO_010081: YKL188C
subclass of: SO_0000673
so part of: YKL188C
location: complement(86225..88786)
location: region:86225-88786:-1
so has part: feature:86225-88786:-1:exon

NP_012733.1
type: Protein
SIO_000068: ncbiprotein

S000001671
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86225-88786:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1104; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 88789..89287
location: region:88789-89287:1
so has part: feature:88789-89287:1:region

S000130138
type: SGD
SIO_000068: sgd

position:88789:1
position: 88789
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:89287:1
position: 89287
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:88789-89287:1:region

YKL187C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAT3
locus tag: YKL187C
so part of: sequence
location: complement(<89284..>91536)
location: region:89284-91536:-1
so has part: feature:89284-91536:-1:exon
subclass of: SO_0000010

853648
type: Gene
SIO_000068: ncbigene

position:89284:-1
position: 89284
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:91536:-1
position: 91536
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:89284-91536:-1:exon

YKL187C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAT3
locus tag: YKL187C
product: Fat3p
transcript id: NM_001179753.1
SIO_010081: YKL187C
subclass of: SO_0000673
so part of: YKL187C
location: complement(<89284..>91536)
location: region:89284-91536:-1
so has part: feature:89284-91536:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:89284-91536:-1:exon

YKL187C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAT3
locus tag: YKL187C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015909 long-chain fatty acid transport [PMID:23349476]
note: Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication
codon start: 1
product: Fat3p
translation: MRIEKHRTPLSKGIIWTILSVCLLFMFTTLILVIVATAGSTANYKPLTNIYIGEADIKHINVSKVIPQIGPILTILGSALTAPNSSLDDIFGAMKNIADTPALTPLLTLLSNADNTTVTIESLTELAPLAISGNPASSTRQLTEINGLLKYSDNATETLDGLSRLVSASLSSASSNSSSDSTTLVLDLLKDSDNPQNSTDALLTLNNLTMSEKAQLLPVFRLFAFSTNQTATMTALATLMNTTISSSLAQTLLTQLQNTISNGGSLNNTFSTLQPLVPQASAPAFDAVELLLNQTTSTNQTLSTLSDLLEQNLTQSSSAKKAFAALTQLMENSDNSTMVVTSVQSLAAVTNTTQSTQQLIGLDDVISSSSNTNETLSILSELQSGLSGNSSSVQYIPYLFSLLGASTDPKTTFSSLVTLTSWAQENPQTFLPILDILADAKSVQPISAEELNAMTPNILEYLKIPIYYRLSIFTLCHANLENKILDCNSPHAVQNLDFRSIIYDALVTSDFQPYLNALNISANDLYLEGKLLHREHQYVPAVRSVLALNLLAIIFSFFTMIFIILLYFNRYMFKQPLWLIALALHVCVGVATVLAAIIISVMIAIIKSGTADDKYGVVFKAGPAYTGLIWTAFALSFIATGLIIYTWWRNRRSGRYMSGSVTNRKGEIYTYGDGSAISADRFGDHNLGDDDDADFEKQVNRNEITAIDNSSSANNTDVTGSTSNRTELSHPDVTPKDSNGPVNNNAHLVA
SIO_010081: YKL187C
subclass of: SO_0000673
so part of: YKL187C
location: complement(89284..91536)
location: region:89284-91536:-1
so has part: feature:89284-91536:-1:exon

NP_012734.1
type: Protein
SIO_000068: ncbiprotein

S000001670
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:89284-91536:-1:exon

YKL186C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTR2
locus tag: YKL186C
so part of: sequence
location: complement(<92744..>93298)
location: region:92744-93298:-1
so has part: feature:92744-93298:-1:exon
subclass of: SO_0000010

853649
type: Gene
SIO_000068: ncbigene

position:92744:-1
position: 92744
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:93298:-1
position: 93298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92744-93298:-1:exon

YKL186C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTR2
locus tag: YKL186C
product: Mtr2p
transcript id: NM_001179752.1
SIO_010081: YKL186C
subclass of: SO_0000673
so part of: YKL186C
location: complement(<92744..>93298)
location: region:92744-93298:-1
so has part: feature:92744-93298:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92744-93298:-1:exon

YKL186C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTR2
locus tag: YKL186C
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126|PMID:31439809]
experiment: EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22956913]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:29212662]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:29212662]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7865887|PMID:9774696]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10952996]
experiment: EXISTENCE:physical interaction:GO:0042272 nuclear RNA export factor complex [PMID:9774696]
note: mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
codon start: 1
product: Mtr2p
translation: MNTNSNTMVMNDANQAQITATFTKKILAHLDDPDSNKLAQFVQLFNPNNCRIIFNATPFAQATVFLQMWQNQVVQTQHALTGVDYHAIPGSGTLICNVNCKVRFDESGRDKMGQDATVPIQPNNTGNRNRPNDMNKPRPLWGPYFGISLQLIIDDRIFRNDFNGVISGFNYNMVYKPEDSLLKI
SIO_010081: YKL186C
subclass of: SO_0000673
so part of: YKL186C
location: complement(92744..93298)
location: region:92744-93298:-1
so has part: feature:92744-93298:-1:exon

NP_012735.1
type: Protein
SIO_000068: ncbiprotein

S000001669
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92744-93298:-1:exon

YKL185W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASH1
locus tag: YKL185W
so part of: sequence
location: <94499..>96265
location: region:94499-96265:1
so has part: feature:94499-96265:1:exon
subclass of: SO_0000010

853650
type: Gene
SIO_000068: ncbigene

position:94499:1
position: 94499
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:96265:1
position: 96265
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94499-96265:1:exon

YKL185W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASH1
locus tag: YKL185W
product: DNA-binding transcription repressor ASH1
transcript id: NM_001179751.1
SIO_010081: YKL185W
subclass of: SO_0000673
so part of: YKL185W
location: <94499..>96265
location: region:94499-96265:1
so has part: feature:94499-96265:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94499-96265:1:exon

YKL185W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASH1
locus tag: YKL185W
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:11171979]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:19841732]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8625408|PMID:9566907|PMID:8625409]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:8625408|PMID:8625409]
experiment: EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16314178|PMID:19040720]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:direct assay:GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [PMID:19841732]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8625408|PMID:8625409]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:11171979]
experiment: EXISTENCE:mutant phenotype:GO:1900461 positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [PMID:11046133]
experiment: EXISTENCE:mutant phenotype:GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter [PMID:19841732]
note: Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
codon start: 1
product: DNA-binding transcription repressor ASH1
translation: MSSLYIKTPLHALSAGPDSHANSSYYDNLLLPSFSNLSSNISRNNITTDNNINSASPRKYSFHSLNVSPILSPISLANEILGKKSNTAPASPHHMDYNPISSLTPGNSPEFNKASLSQISFTNPLNYGSGLGFSSNSQPRLPLLDRLSSVSLSKRPERPQQSLPSLRHLQLLPSPLLQENAARFPDTSKRTSNWKTDLTHWCKDTNYQDYVKIREEVAHFKPLSIPNLTNNQNNDSFNYGKELESTRSSKFHSPSKESFDRTKLIPSILEAKDQFKDLSNNAWSITPPVTPPMSPPTNRTMERTTLRGVEASFFEGKSSNNDSIFNPIISEKLVQEVKHQRQLRGNSFPMPNASHKKTNSFKALQIKKLLANRDILSNNSKSNVRKPSKNKISKQASNVFGNTARQLVMKLDNASYSSVSASSSPSPSTPTKSGKMRSRSSSPVRPKAYTPSPRSPNYHRFALDSPPQSPRRSSNSSITKKGSRRSSGSSPTRHTTRVCVSCHSSDSPCWRPSWSPRKQDQLCNSCGLRYKKTHTRCLNDLCRKIPTKGEINIMKSNGIDKEFVPERNCEIEGYRCLFCNYITETVEN
SIO_010081: YKL185W
subclass of: SO_0000673
so part of: YKL185W
location: 94499..96265
location: region:94499-96265:1
so has part: feature:94499-96265:1:exon

NP_012736.1
type: Protein
SIO_000068: ncbiprotein

S000001668
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94499-96265:1:exon

YKL184W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ORD1
alternative label: SPE10
gene: SPE1
locus tag: YKL184W
gene synonym: ORD1; SPE10
so part of: sequence
location: <96757..>98157
location: region:96757-98157:1
so has part: feature:96757-98157:1:exon
subclass of: SO_0000010

853651
type: Gene
SIO_000068: ncbigene

position:96757:1
position: 96757
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:98157:1
position: 98157
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96757-98157:1:exon

YKL184W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ORD1
alternative label: SPE10
gene: SPE1
locus tag: YKL184W
gene synonym: ORD1; SPE10
product: ornithine decarboxylase SPE1
transcript id: NM_001179750.1
SIO_010081: YKL184W
subclass of: SO_0000673
so part of: YKL184W
location: <96757..>98157
location: region:96757-98157:1
so has part: feature:96757-98157:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:96757-98157:1:exon

YKL184W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ORD1
alternative label: SPE10
gene: SPE1
locus tag: YKL184W
gene synonym: ORD1; SPE10
EC number: 4.1.1.17
experiment: EXISTENCE:direct assay:GO:0004586 ornithine decarboxylase activity [PMID:2681188]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0009446 putrescine biosynthetic process [PMID:7929015]
experiment: EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]
note: Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
codon start: 1
product: ornithine decarboxylase SPE1
translation: MSSTQVGNALSSSTTTLVDLSNSTVTQKKQYYKDGETLHNLLLELKNNQDLELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGEVKRLFNNWVKELPRIKPFYAVKCNPDTKVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYANPCKVASFIRYAASKNVMKSTFDNVEELHKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEMENVDVLLKAIKELGLNLAGVSFHVGSGASDFTSLYKAVRDARTVFDKAANEYGLPPLKILDVGGGFQFESFKESTAVLRLALEEFFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENEAMIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPTCDGLDCIAKEYYMKHDVIVGDWFYFPALGAYTSSAATQFNGFEQTADIVYIDSELD
SIO_010081: YKL184W
subclass of: SO_0000673
so part of: YKL184W
location: 96757..98157
location: region:96757-98157:1
so has part: feature:96757-98157:1:exon

NP_012737.1
type: Protein
SIO_000068: ncbiprotein

S000001667
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:96757-98157:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1125; Autonomously Replicating Sequence
so part of: sequence
location: 98364..98523
location: region:98364-98523:1
so has part: feature:98364-98523:1:region

S000119035
type: SGD
SIO_000068: sgd

position:98364:1
position: 98364
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:98523:1
position: 98523
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98364-98523:1:region

YKL183C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL183C-A
so part of: sequence
location: complement(<98395..>98607)
location: region:98395-98607:-1
so has part: feature:98395-98607:-1:exon
subclass of: SO_0000010

1500485
type: Gene
SIO_000068: ncbigene

position:98395:-1
position: 98395
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:98607:-1
position: 98607
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98395-98607:-1:exon

YKL183C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL183C-A
product: uncharacterized protein
transcript id: NM_001184557.1
SIO_010081: YKL183C-A
subclass of: SO_0000673
so part of: YKL183C-A
location: complement(<98395..>98607)
location: region:98395-98607:-1
so has part: feature:98395-98607:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98395-98607:-1:exon

YKL183C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL183C-A
note: hypothetical protein; identified by fungal homology and RT-PCR
codon start: 1
product: uncharacterized protein
translation: MYSKILLYRSNVLFMNFFSVFVCTIGTLFLVFADVYVLASAFFQSKKEKETKFKHLHYQKRSCFFLANIH
SIO_010081: YKL183C-A
subclass of: SO_0000673
so part of: YKL183C-A
location: complement(98395..98607)
location: region:98395-98607:-1
so has part: feature:98395-98607:-1:exon

NP_878109.1
type: Protein
SIO_000068: ncbiprotein

S000028558
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98395-98607:-1:exon

YKL183W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LOT5
locus tag: YKL183W
so part of: sequence
location: <98721..>99641
location: region:98721-99641:1
so has part: feature:98721-99641:1:exon
subclass of: SO_0000010

853652
type: Gene
SIO_000068: ncbigene

position:98721:1
position: 98721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99641:1
position: 99641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98721-99641:1:exon

YKL183W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LOT5
locus tag: YKL183W
product: Lot5p
transcript id: NM_001179749.1
SIO_010081: YKL183W
subclass of: SO_0000673
so part of: YKL183W
location: <98721..>99641
location: region:98721-99641:1
so has part: feature:98721-99641:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98721-99641:1:exon

YKL183W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LOT5
locus tag: YKL183W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
codon start: 1
product: Lot5p
translation: MMKKKPKCQIARTKPSVENVIPYNQFKKTQPRFNGNFSALNNEEYIILFGGGRDLILGSLTPCSSSHLSNQANPQDTSEYGTDLFILNSCIIIWFNGLGYGLEIPYSSVLYHASRRLPDGREGLQLEILLTLERDEVLDMLYQSLAPQACEFDGEEAHAFTVRSVELTIRPKYSIYDRHYNNEIETLFTFENFGVNRGDDLVNNCNEALAVCMDLHGEDVQDQDQEQYQDPSMAFEGAQDLNATYSGLGDTLHGPPVYQNDGLADDLDGDLVMDNVVSRGGPEASMSMEFYANQNLAGRKNSRDNE
SIO_010081: YKL183W
subclass of: SO_0000673
so part of: YKL183W
location: 98721..99641
location: region:98721-99641:1
so has part: feature:98721-99641:1:exon

NP_012738.1
type: Protein
SIO_000068: ncbiprotein

S000001666
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98721-99641:1:exon

YKL182W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAS1
locus tag: YKL182W
so part of: sequence
location: <100671..>106826
location: region:100671-106826:1
so has part: feature:100671-106826:1:exon
subclass of: SO_0000010

853653
type: Gene
SIO_000068: ncbigene

position:100671:1
position: 100671
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:106826:1
position: 106826
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100671-106826:1:exon

YKL182W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAS1
locus tag: YKL182W
product: tetrafunctional fatty acid synthase subunit FAS1
transcript id: NM_001179748.1
SIO_010081: YKL182W
subclass of: SO_0000673
so part of: YKL182W
location: <100671..>106826
location: region:100671-106826:1
so has part: feature:100671-106826:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100671-106826:1:exon

YKL182W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAS1
locus tag: YKL182W
EC number: 1.3.1.9
EC number: 2.3.1.38
EC number: 2.3.1.39
EC number: 2.3.1.86
EC number: 3.1.2.14
EC number: 4.2.1.59
experiment: EXISTENCE:direct assay:GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity [PMID:374077]
experiment: EXISTENCE:direct assay:GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity [PMID:365179|PMID:374077]
experiment: EXISTENCE:direct assay:GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [PMID:374077]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:17803462]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6025308]
experiment: EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:65153]
experiment: EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:365179]
experiment: EXISTENCE:direct assay:GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:374077]
experiment: EXISTENCE:mutant phenotype:GO:0004312 fatty acid synthase activity [PMID:1100391|PMID:65153]
experiment: EXISTENCE:mutant phenotype:GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity [PMID:1100391]
experiment: EXISTENCE:mutant phenotype:GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity [PMID:1100391]
experiment: EXISTENCE:mutant phenotype:GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [PMID:1100391]
experiment: EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:1100391]
experiment: EXISTENCE:mutant phenotype:GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:1100391]
experiment: EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:1735446|PMID:4127627]
note: Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
codon start: 1
product: tetrafunctional fatty acid synthase subunit FAS1
translation: MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKEN…
SIO_010081: YKL182W
subclass of: SO_0000673
so part of: YKL182W
location: 100671..106826
location: region:100671-106826:1
so has part: feature:100671-106826:1:exon

NP_012739.1
type: Protein
SIO_000068: ncbiprotein

S000001665
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100671-106826:1:exon

YKL181W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PRP1
gene: PRS1
locus tag: YKL181W
gene synonym: PRP1
so part of: sequence
location: <107316..>108599
location: region:107316-108599:1
so has part: feature:107316-108599:1:exon
subclass of: SO_0000010

853654
type: Gene
SIO_000068: ncbigene

position:107316:1
position: 107316
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108599:1
position: 108599
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:107316-108599:1:exon

YKL181W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PRP1
gene: PRS1
locus tag: YKL181W
gene synonym: PRP1
product: ribose phosphate diphosphokinase subunit PRS1
transcript id: NM_001179747.1
SIO_010081: YKL181W
subclass of: SO_0000673
so part of: YKL181W
location: <107316..>108599
location: region:107316-108599:1
so has part: feature:107316-108599:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:107316-108599:1:exon

YKL181W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PRP1
gene: PRS1
locus tag: YKL181W
gene synonym: PRP1
EC number: 2.7.6.1
experiment: EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11101685|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]
experiment: EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]
experiment: EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]
experiment: EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:15470112]
note: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease
codon start: 1
product: ribose phosphate diphosphokinase subunit PRS1
translation: MRKCKIFVGNSHPELGNMVCQRLGIEPAPCTLKKFANGETSVQIGVSVRDEDVYVIQSGSPSINDDIMELLILVSACRGGSARKITAVIPQFPYSKQCKMKRHRGAITARMLANLLVMAGADHVVSMDLHASQMQGFFTKPVDNLYGGPSLAKWIRENVEDYEDAVVVSKNPGGTKRVTALADSLKINFAMIHTDRRRSKDLYSQNKDLQQLKLRKQSMLRKNRPIIRQGDHPNEEENIILSNGIQTARIRNGHVIGDDEADDDEDAILESDSELHSIDGLDSHGLGGTYDAVDSEDEEEIPVLYREQLITLVGNVRGRSAIILDDMIDRPGSFISAAEHLVQNCGAKKVYVVATHGIFTGDCLEELEKSDAIDTIVVTNTYPISGERIAGSKKLVTIDVSPIFAECIRRDHYGESISVLFDSLAAL
SIO_010081: YKL181W
subclass of: SO_0000673
so part of: YKL181W
location: 107316..108599
location: region:107316-108599:1
so has part: feature:107316-108599:1:exon

NP_012740.1
type: Protein
SIO_000068: ncbiprotein

S000001664
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:107316-108599:1:exon

YKL180W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL17
gene: RPL17A
locus tag: YKL180W
gene synonym: RPL17
so part of: sequence
location: <109269..>110129
location: region:109269-110129:1
so has part: feature:109269-110129:1:exon
subclass of: SO_0000010

853674
type: Gene
SIO_000068: ncbigene

position:109269:1
position: 109269
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110129:1
position: 110129
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:109269-110129:1:exon

YKL180W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL17
gene: RPL17A
locus tag: YKL180W
gene synonym: RPL17
product: ribosomal 60S subunit protein L17A
transcript id: NM_001179746.1
SIO_010081: YKL180W
subclass of: SO_0000673
so part of: YKL180W
location: join(<109269..109577,109884..>110129)
location: region:109269-110129:1
so has part: feature:109269-109577:1:exon
so has part: feature:109884-110129:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:109269-109577:1:exon

position:109577:1
position: 109577
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:109884-110129:1:exon

position:109884:1
position: 109884
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL180W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL17
gene: RPL17A
locus tag: YKL180W
gene synonym: RPL17
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]
experiment: EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]
note: Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: ribosomal 60S subunit protein L17A
translation: MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQVLDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAANAEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKVVRLTSRQRGRIAAQKRIAA
SIO_010081: YKL180W
subclass of: SO_0000673
so part of: YKL180W
location: join(109269..109577,109884..110129)
location: region:109269-110129:1
so has part: feature:109269-109577:1:exon
so has part: feature:109884-110129:1:exon

NP_012741.1
type: Protein
SIO_000068: ncbiprotein

S000001663
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:109269-109577:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:109884-110129:1:exon

YKL179C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COY1
locus tag: YKL179C
so part of: sequence
location: complement(<110464..>112503)
location: region:110464-112503:-1
so has part: feature:110464-112503:-1:exon
subclass of: SO_0000010

853675
type: Gene
SIO_000068: ncbigene

position:110464:-1
position: 110464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:112503:-1
position: 112503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110464-112503:-1:exon

YKL179C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COY1
locus tag: YKL179C
product: Coy1p
transcript id: NM_001179745.1
SIO_010081: YKL179C
subclass of: SO_0000673
so part of: YKL179C
location: complement(<110464..>112503)
location: region:110464-112503:-1
so has part: feature:110464-112503:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:110464-112503:-1:exon

YKL179C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COY1
locus tag: YKL179C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:31073031]
experiment: EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:31073031]
experiment: EXISTENCE:direct assay:GO:0048211 Golgi vesicle docking [PMID:31073031]
experiment: EXISTENCE:genetic interaction:GO:0000139 Golgi membrane [PMID:12429822]
experiment: EXISTENCE:genetic interaction:GO:0048193 Golgi vesicle transport [PMID:12429822]
note: Golgi membrane protein with similarity to mammalian CASP; packaged into COPII vesicles for trafficking between ER and Golgi; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
codon start: 1
product: Coy1p
translation: MDTSVYSHALDIWAKADLTNLQRELDADVIEIKDKETLSLNSRKSLATETKKFKKLEPEEKLNNVNKIIKQYQREIDNLTQRSKFSEKVLFDVYEKLSEAPDPQPLLQSSLEKLGKIDDSKELKEKISYLEDKLAKYADYETLKSRLLDLEQSSAKTLAKRLTAKTQEINSTWEEKGRNWKEREADLLKQLTNVQEQNKALEAKISKNIDIEGNGNEDGDQENNQKEVSTRIAEYNLVTQELETTQARIYQLEKRNEELSGALAKATSEAEKETELHAKELKLNQLESENALLSASYEQERKSTSHAINELKEQLNSVVAESESYKSELETVRRKLNNYSDYNKIKEELSALKKIEFGVNEDDSDNDIRSEDKNDNTFESSLLSANKKLQATLAEYRSKSTAQEEERNELKKSVDQLKQQIATLKEANEKLETDLEKVENVSPHFNETASMMSGVTRQMNNRTSHKMSPTSSIIGIPEDGELSGNQSTILPIVTKQRDRFRSRNMDLEKQLRQGNSEKGKLKLEISKLKGDNTKLYERIRYLQSYNNNNAPVNQSTERIDVESQYSRVYDESLHPMANFRQNELNHYKNKKLSALEKLFSSFAKVILQNKMTRMVFLFYCIGLHGLVFMMSMYVINISGYMTPEVGIVQSAKSSSNLNGGLGGAEKVAAGVGSVHGINR
SIO_010081: YKL179C
subclass of: SO_0000673
so part of: YKL179C
location: complement(110464..112503)
location: region:110464-112503:-1
so has part: feature:110464-112503:-1:exon

NP_012742.1
type: Protein
SIO_000068: ncbiprotein

S000001662
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110464-112503:-1:exon

YKL178C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DAF2
gene: STE3
locus tag: YKL178C
gene synonym: DAF2
so part of: sequence
location: complement(<113215..>114627)
location: region:113215-114627:-1
so has part: feature:113215-114627:-1:exon
subclass of: SO_0000010

853677
type: Gene
SIO_000068: ncbigene

position:113215:-1
position: 113215
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:114627:-1
position: 114627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113215-114627:-1:exon

YKL178C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DAF2
gene: STE3
locus tag: YKL178C
gene synonym: DAF2
product: Ste3p
transcript id: NM_001179744.1
SIO_010081: YKL178C
subclass of: SO_0000673
so part of: YKL178C
location: complement(<113215..>114627)
location: region:113215-114627:-1
so has part: feature:113215-114627:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:113215-114627:-1:exon

YKL178C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DAF2
gene: STE3
locus tag: YKL178C
gene synonym: DAF2
experiment: EXISTENCE:direct assay:GO:0000755 cytogamy [PMID:17369365]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:3006051]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3006051]
experiment: EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:17369365]
experiment: EXISTENCE:mutant phenotype:GO:0004933 mating-type a-factor pheromone receptor activity [PMID:3006051]
note: Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR
codon start: 1
product: Ste3p
translation: MSYKSAIIGLCLLAVILLAPPLAWHSHTKNIPAIILITWLLTMNLTCIVDAAIWSDDDFLTRWDGKGWCDIVIKLQVGANIGISCAVTNIIYNLHTILKADSVLPDLSSWTKIVKDLVISLFTPVMVMGFSYLLQVFRYGIARYNGCQNLLSPTWITTVLYTMWMLIWSFVGAVYATLVLFVFYKKRKDVRDILHCTNSGLNLTRFARLLIFCFIIILVMFPFSVYTFVQDLQQVEGHYTFKNTHSSTIWNTIIKFDPGRPIYNIWLYVLMSYLVFLIFGLGSDALHMYSKFLRSIKLGFVLDMWKRFIDKNKEKRVGILLNKLSSRKESRNPFSTDSENYISTCTENYSPCVGTPISQAHFYVDYRIPDDPRKSQNKSKKYLFADKETDDILDEIDLKESRHIPYVTQGQSFDDEISLGGFSKVTLDYSEKLHNSASSNFEGESLCYSPASKEENSSSNEHSSENTAGP
SIO_010081: YKL178C
subclass of: SO_0000673
so part of: YKL178C
location: complement(113215..114627)
location: region:113215-114627:-1
so has part: feature:113215-114627:-1:exon

NP_012743.1
type: Protein
SIO_000068: ncbiprotein

S000001661
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:113215-114627:-1:exon

YKL176C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LST4
locus tag: YKL176C
so part of: sequence
location: complement(<115500..>117986)
location: region:115500-117986:-1
so has part: feature:115500-117986:-1:exon
subclass of: SO_0000010

853678
type: Gene
SIO_000068: ncbigene

position:115500:-1
position: 115500
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:117986:-1
position: 117986
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:115500-117986:-1:exon

YKL176C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LST4
locus tag: YKL176C
product: Lst4p
transcript id: NM_001179742.1
SIO_010081: YKL176C
subclass of: SO_0000673
so part of: YKL176C
location: complement(<115500..>117986)
location: region:115500-117986:-1
so has part: feature:115500-117986:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:115500-117986:-1:exon

YKL176C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LST4
locus tag: YKL176C
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:1990877 FNIP-folliculin RagC/D GAP [PMID:26387955]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:26387955]
note: Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface
codon start: 1
product: Lst4p
translation: MLGNLLRNKTSSSGFEKSSEHSDFSSVVPNVPVYCKAASTGTTKTAAGALLDTAVNVEKPSEMLSTTSPPILDHISDDLKLKLFGSRDIPYSRPIDTLQNNGGLGTDKITSINEKTYAFRILIIEEAGQMACRNNYRDIFDYTTSKISNSMEQIRPSELKEYIFGSPVRSSDLTQCDKIRTIPNSDLVLITRIFYYTHQYNRIAISLCIPRILLPVVAESWSSISSWLTQTQKMLIGFLTKNRIMQENTGNYSNNSVIKLSNIDIRTHYPKEIEIMVQTLQKRVIPGLRSMSEIPRLFLYPETFKEFVHVWFKSIFNWIEIKDGPKLGFLPLLMAMIISDYRHTIRELKTSKIVILSGNMVVANKLLFILSALLEPKYKGQITIRRENIRSDSSAVSRNKSNNNFVDKPETELSTLTSTDNLLSRTENNSNHNYNNSNVSSNSIGSPNFHSLRKGWQIPNRRNSNTSVSVSSSESLAEVIQPSSFKSGSSSLHYLSSSISSQPGSYGSWFNKRPTISQFFQPSPSLKHNESWERLQTTAGNMQRTSSSSSLQQATSRLSLTTPQQSPSISEYDEYPWMGTPGSPNVGDVSHAPPLVKNISYKFPLKNVELKRDCQRISQDDLLDEAFERICQPSLADLNSTYEIFPGNSSYADILTTDSDIDDGLMNKPLELLPKYTMYLTHFNNFFQLQACPAGQESESRITNSMKIDLLKADYTRSLLVSLRSRDIRDVALKREFTGNNNNNSNQNIYDENFVGKRKYVLKQKTRKIFSCGKIGKLSTSLENCVNFVENSIKSAMMLYDDNGIDSELRDSEALRIFSSLVHYCNAG
SIO_010081: YKL176C
subclass of: SO_0000673
so part of: YKL176C
location: complement(115500..117986)
location: region:115500-117986:-1
so has part: feature:115500-117986:-1:exon

NP_012745.1
type: Protein
SIO_000068: ncbiprotein

S000001659
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:115500-117986:-1:exon

YKL175W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZRT3
locus tag: YKL175W
so part of: sequence
location: <118793..>120304
location: region:118793-120304:1
so has part: feature:118793-120304:1:exon
subclass of: SO_0000010

853679
type: Gene
SIO_000068: ncbigene

position:118793:1
position: 118793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:120304:1
position: 120304
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118793-120304:1:exon

YKL175W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZRT3
locus tag: YKL175W
product: Zn(2+) transporter ZRT3
transcript id: NM_001179741.1
SIO_010081: YKL175W
subclass of: SO_0000673
so part of: YKL175W
location: <118793..>120304
location: region:118793-120304:1
so has part: feature:118793-120304:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:118793-120304:1:exon

YKL175W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZRT3
locus tag: YKL175W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10856230]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:10856230]
experiment: EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:10856230]
experiment: EXISTENCE:mutant phenotype:GO:0006882 cellular zinc ion homeostasis [PMID:10856230]
note: Vacuolar membrane zinc transporter; transports zinc from storage in vacuole to cytoplasm when needed; transcription induced under conditions of zinc deficiency; targeted to vacuole via AP-3 pathway
codon start: 1
product: Zn(2+) transporter ZRT3
translation: MEKIPRWLLFSLISSVLCILGALCVPLLSVAFDSKRNSQSKLVNYGLSLSAGSMITTSLYMLLPRIEKSNRFKVFPGLLLGICLSFFLNYLVHAFASESLVHCADSGDHATGSHIHSKSHSHSHSHSHADSHSNFSNDHDLENAPSEHGYATSSSSVSENDPLITKDSDRPQMKKKMSLIDLLTRRKSEGECCDLNKCTPLLQSEQPEYIACVPPVIKSSQSERNVPHGCEGSEDNGQSDDKDHRGLVCVENNIGYDLENLSLYRKNFLSSRHHHSSESPENYGSNQLSHSFSSPLGNDVTENPAALADTQYHPENGSLYPHHHHLETPFSKLLSIGMQTCLVLALHKFPEGFIIFYTNRSDSSKSLGFSIFLSLTIHNFVEGFAMTLPFYTVFESKWVAILITAVLGGGSQPLGALIGYFIFKGSTPRDHEPNMDFLLSVTAGFLLVIGLQMFQTGIGFSDGHHHHQGEGDEEMKQSHSSGTTCLKWCCTGVLLILASALFT
SIO_010081: YKL175W
subclass of: SO_0000673
so part of: YKL175W
location: 118793..120304
location: region:118793-120304:1
so has part: feature:118793-120304:1:exon

NP_012746.1
type: Protein
SIO_000068: ncbiprotein

S000001658
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:118793-120304:1:exon

YKL174C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPO5
locus tag: YKL174C
so part of: sequence
location: complement(<120380..>122236)
location: region:120380-122236:-1
so has part: feature:120380-122236:-1:exon
subclass of: SO_0000010

853680
type: Gene
SIO_000068: ncbigene

position:120380:-1
position: 120380
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:122236:-1
position: 122236
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:120380-122236:-1:exon

YKL174C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPO5
locus tag: YKL174C
product: Tpo5p
transcript id: NM_001179740.1
SIO_010081: YKL174C
subclass of: SO_0000673
so part of: YKL174C
location: complement(<120380..>122236)
location: region:120380-122236:-1
so has part: feature:120380-122236:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:120380-122236:-1:exon

YKL174C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPO5
locus tag: YKL174C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15668236]
experiment: EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:15668236]
experiment: EXISTENCE:mutant phenotype:GO:0015846 polyamine transport [PMID:15668236]
note: Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
codon start: 1
product: Tpo5p
translation: MPEYTLLADNIRENIVHFDPNGLFDNLHTIVHEDDSQENEEAEHFNYDQVLDKSLLSRGSIVGLGLGLMSPVLGMCTSMAIGLINGGPLTIMLGFLISGVCIWFSSLSLGEIVSKFPMELHVGSAMLAPEKLKLVCSWYTGWLMLIGNWTMSTSITFAGAQLTISLILMTNSNLISEAHLIFYTVIVFYLVVTVVGLVNLKFARFIETINKVCVYWIIYAIIFIDILLLVFHKGKFRSLKYALFHFDNNLSGYKSAFLSFIIGFQQSNFTLQGFSMLPALADEVKVPEKDIPRGMSNAVLLSAFSGVIFLIPIMLILPDNDLLFTNHKVLPIVNIFTKSTDSVVLSFFLVLLILGNLLFSGIGSITTSSRAVYSFSRDQAIPYYDKWTYVEPDSQSKVPKNSVVLSMIISYFLGLLALISTAAFNAFIGAAVLCLCSATFIPLVLVLFTRRRAIRSAPVKIRYKFGWFINIVSIVWLLLSMVSVCLPTQVPVTFKTMNYALMVYVFCILVITGLYFKWGKYNFRLPLADDIKAPIPSDAEETVFELEDSNVEHTLNSGTTVKESVENNSEEGFIKVHPKSSTENPFEENEENVITDYGDEHHTAEQEFDLADDRRYDI
SIO_010081: YKL174C
subclass of: SO_0000673
so part of: YKL174C
location: complement(120380..122236)
location: region:120380-122236:-1
so has part: feature:120380-122236:-1:exon

NP_012747.1
type: Protein
SIO_000068: ncbiprotein

S000001657
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:120380-122236:-1:exon

YKL173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GIN10
gene: SNU114
locus tag: YKL173W
gene synonym: GIN10
so part of: sequence
location: <122517..>125543
location: region:122517-125543:1
so has part: feature:122517-125543:1:exon
subclass of: SO_0000010

853681
type: Gene
SIO_000068: ncbigene

position:122517:1
position: 122517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:125543:1
position: 125543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122517-125543:1:exon

YKL173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GIN10
gene: SNU114
locus tag: YKL173W
gene synonym: GIN10
product: U5 snRNP GTPase SNU114
transcript id: NM_001179739.1
SIO_010081: YKL173W
subclass of: SO_0000673
so part of: YKL173W
location: <122517..>125543
location: region:122517-125543:1
so has part: feature:122517-125543:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122517-125543:1:exon

YKL173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GIN10
gene: SNU114
locus tag: YKL173W
gene synonym: GIN10
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]
experiment: EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:9848662]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:genetic interaction:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:15911574]
experiment: EXISTENCE:mutant phenotype:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:16540695]
experiment: EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:16540695]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9233818]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:9233818]
note: GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
codon start: 1
product: U5 snRNP GTPase SNU114
translation: MEGDDLFDEFGNLIGVDPFDSDEEESVLDEQEQYQTNTFEGSGNNNEIESRQLTSLGSKKELGISLEHPYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLHDISKTETSNEDEDEDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNESFASIPVSNSISRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKGISTGGFMSNDGPTLEKYISAELYAQLRENGLVP
SIO_010081: YKL173W
subclass of: SO_0000673
so part of: YKL173W
location: 122517..125543
location: region:122517-125543:1
so has part: feature:122517-125543:1:exon

NP_012748.1
type: Protein
SIO_000068: ncbiprotein

S000001656
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122517-125543:1:exon

YKL172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EBP2
locus tag: YKL172W
so part of: sequence
location: <125759..>127042
location: region:125759-127042:1
so has part: feature:125759-127042:1:exon
subclass of: SO_0000010

853682
type: Gene
SIO_000068: ncbigene

position:125759:1
position: 125759
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:127042:1
position: 127042
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:125759-127042:1:exon

YKL172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EBP2
locus tag: YKL172W
product: Ebp2p
transcript id: NM_001179738.1
SIO_010081: YKL172W
subclass of: SO_0000673
so part of: YKL172W
location: <125759..>127042
location: region:125759-127042:1
so has part: feature:125759-127042:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:125759-127042:1:exon

YKL172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EBP2
locus tag: YKL172W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10849420]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:21822217]
experiment: EXISTENCE:mutant phenotype:GO:0000280 nuclear division [PMID:15515129]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10849420]
note: Protein required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
codon start: 1
product: Ebp2p
translation: MAKGFKLKELLSHQKEIEKAEKLENDLKKKKSQELKKEEPTIVTASNLKKLEKKEKKADVKKEVAADTEEYQSQALSKKEKRKLKKELKKMQEQDATEAQKHMSGDEDESGDDREEEEEEEEEEEGRLDLEKLAKSDSESEDDSESENDSEEDEDVVAKEESEEKEEQEEEQDVPLSDVEFDSDADVVPHHKLTVNNTKAMKHALERVQLPWKKHSFQEHQSVTSETNTDEHIKDIYDDTERELAFYKQSLDAVLVARDELKRLKVPFKRPLDYFAEMVKSDEHMDKIKGKLIEEASDKKAREEARRQRQLKKFGKQVQNATLQKRQLEKRETLEKIKSLKNKRKHNEIDHSEFNVGVEEEVEGKRFDRGRPNGKRAAKNAKYGQGGMKRFKRKNDATSSADVSGFSSRKMKGKTNRPGKSRRARRF
SIO_010081: YKL172W
subclass of: SO_0000673
so part of: YKL172W
location: 125759..127042
location: region:125759-127042:1
so has part: feature:125759-127042:1:exon

NP_012749.1
type: Protein
SIO_000068: ncbiprotein

S000001655
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:125759-127042:1:exon

YKL171W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NNK1
locus tag: YKL171W
so part of: sequence
location: <127475..>130261
location: region:127475-130261:1
so has part: feature:127475-130261:1:exon
subclass of: SO_0000010

853683
type: Gene
SIO_000068: ncbigene

position:127475:1
position: 127475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130261:1
position: 130261
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:127475-130261:1:exon

YKL171W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NNK1
locus tag: YKL171W
product: protein kinase NNK1
transcript id: NM_001179737.1
SIO_010081: YKL171W
subclass of: SO_0000673
so part of: YKL171W
location: <127475..>130261
location: region:127475-130261:1
so has part: feature:127475-130261:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:127475-130261:1:exon

YKL171W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NNK1
locus tag: YKL171W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]
experiment: EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:11595789]
note: Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
codon start: 1
product: protein kinase NNK1
translation: MFTSQRQLRQNGSPMSSSRSSQHSSGTASPISDSPASNRSYGRDLRGLMGIDIPANEPAFNRANSSDTIYFRPKKIYKMEHEHPSRSTLVQLQTRSQPDDVASSQVNPEGGTDDLELGDPCGNQSLYTIGAEYVPDLDFTKLVNEWQKSTEDLYEFRSSATPQVQIKDSGKGNYELWSSPDAILTQNKLRRDSFSQENSDSLSPEDSILSRNLHSKVKPIPLPRNSQQIFTPLSNLEAERRSSYTTSSNNNSITQNNKFSFAKLKYSLPTQSSAVPASFDSNASSLNFLPTTTLSTLSELQISPNDMMDLIQKLPRNFLNLPYTQRKKVIIEHAPSHDYKAMMSLVKKFMLTSSRSNFSLAGFANNASVSQATANDDNINSRNTPNNSNDTYVNTRPLQRSRHGSIASQFLSSFSPSMTSIAKMNSNPLSGSAGGSARPDDKGMEILGHRLGKIIGFGAWGIIRECFDIETGVGRVIKIVKFKGHQNIKKHVLREVAIWRTLKHNRILPLLDWKLDDNYAMYCLTERINDGTLYDLVISWDEFKRSKIPFAERCRLTIFLSLQLLSALKYMHSKTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHFDEKHVYRNDTFDENLSSGNSHRKRKSIEQTNLIKYPTTNFLPDDRTNDFDASENLKYQFENRKHQPFTPKGMVSSSSHSLKHLNQPSSSSSSNLFHKPASQPQPQHRSPFHGRHKTTDFSNLEPEPSKYIGSLPYASPELLRYSDARRSKSVEMHIYDSPDSSQSEISAASSSSSNLSSLSSSTKASAVTNSGVTTSSPSGSSTDFPCIVSPLGPASDIWALGVMLYTMLVGKLPFNHEFEPRLRSLIKVGEFDRFSLAQVCKFDRKKNEGTIGQGLYDTVIGCLTIDLDKRWKLKRIEEVLQNEMNLSEAIHDNNGS
SIO_010081: YKL171W
subclass of: SO_0000673
so part of: YKL171W
location: 127475..130261
location: region:127475-130261:1
so has part: feature:127475-130261:1:exon

NP_012750.1
type: Protein
SIO_000068: ncbiprotein

S000001654
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:127475-130261:1:exon

YKL170W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL14m
gene: MRPL38
locus tag: YKL170W
gene synonym: uL14m
so part of: sequence
location: <130634..>131050
location: region:130634-131050:1
so has part: feature:130634-131050:1:exon
subclass of: SO_0000010

853684
type: Gene
SIO_000068: ncbigene

position:130634:1
position: 130634
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131050:1
position: 131050
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:130634-131050:1:exon

YKL170W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL14m
gene: MRPL38
locus tag: YKL170W
gene synonym: uL14m
product: mitochondrial 54S ribosomal protein YmL38/YmL34
transcript id: NM_001179736.1
SIO_010081: YKL170W
subclass of: SO_0000673
so part of: YKL170W
location: <130634..>131050
location: region:130634-131050:1
so has part: feature:130634-131050:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:130634-131050:1:exon

YKL170W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL14m
gene: MRPL38
locus tag: YKL170W
gene synonym: uL14m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
codon start: 1
product: mitochondrial 54S ribosomal protein YmL38/YmL34
translation: MIFLKSVIKVIDNSGAQLAECIKVIRKGSPKSPAMVGDRIVCVIQKAKPLTQNITGTANTNRVKKGDICHAIVVRSKQRNMCRKDGSTVAFGDTACVLINKNTGEPLGTRIMANDGCVDRTLKDKGYNKICSLASRVI
SIO_010081: YKL170W
subclass of: SO_0000673
so part of: YKL170W
location: 130634..131050
location: region:130634-131050:1
so has part: feature:130634-131050:1:exon

NP_012751.1
type: Protein
SIO_000068: ncbiprotein

S000001653
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:130634-131050:1:exon

YKL168C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KKQ8
locus tag: YKL168C
so part of: sequence
location: complement(<131288..>133462)
location: region:131288-133462:-1
so has part: feature:131288-133462:-1:exon
subclass of: SO_0000010

853686
type: Gene
SIO_000068: ncbigene

position:131288:-1
position: 131288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:133462:-1
position: 133462
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131288-133462:-1:exon

YKL168C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KKQ8
locus tag: YKL168C
product: putative serine/threonine protein kinase KKQ8
transcript id: NM_001179734.1
SIO_010081: YKL168C
subclass of: SO_0000673
so part of: YKL168C
location: complement(<131288..>133462)
location: region:131288-133462:-1
so has part: feature:131288-133462:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:131288-133462:-1:exon

YKL168C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KKQ8
locus tag: YKL168C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]
note: Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
codon start: 1
product: putative serine/threonine protein kinase KKQ8
translation: MVMQEEKKRQQPVTRRVRSFSESFKNLFRPPRSRDSSPINVTRIPYRSSSTSPKRSSEPPRRSTVSAQILDPKNSPIRQRSYTLKCCTPGLSHPFRQTGSGASNSPTRHRSISGEEQEIVNSLPEYKRSASHTFHGIRRPRSRSSSVSSCDSSNGTTSSSDSQWAMDSLLDDSDNDLTPYRGSNKDILKSKDRAPYNYIDDYNKKALRRATSYPNPLPSKQFYNERLYTRRSHPDEESLESLPRFAGADVQCIIEQNGFKVYEDGSHEHNIKLSGVIAKLEKGNSLPAHRQGSLSRPRLGITLSGLFKHHKNECDIENALSLLPNVEKSQTNHEKRTGQSPNDSNRSSPTQGREDYLKIVNPDASLGSDELKLINSLSSRIHKSLQNYLQEKNLKPAECIGEQAPTFQDNYGHPVGLVGAGAYGEVKLCARLRNEKDSPPFETYHDSKYIYYAVKELKPKPDSDLEKFCTKITSEFIIGHSLSHYHKNGKKPAPNILNVFDILEDSSSFIEVMEFCPAGDLYGMLVGKSKLKGRLHPLEADCFMKQLLHGVKFMHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVFQTAWERRVHAQKGIIGSEPYVAPEEFVDGEYYDPRLIDCWSCGVVYITMILGHYLWKVASREKDMSYDEFYKEMQRKNQFRVFEELKHVNSELATNRKIALYRIFQWEPRKRISVGKLLDMQWMKSTNCCLIYDST
SIO_010081: YKL168C
subclass of: SO_0000673
so part of: YKL168C
location: complement(131288..133462)
location: region:131288-133462:-1
so has part: feature:131288-133462:-1:exon

NP_012753.2
type: Protein
SIO_000068: ncbiprotein

S000001651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131288-133462:-1:exon

YKL167C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL61
gene: MRP49
locus tag: YKL167C
gene synonym: mL61
so part of: sequence
location: complement(<133721..>134134)
location: region:133721-134134:-1
so has part: feature:133721-134134:-1:exon
subclass of: SO_0000010

853687
type: Gene
SIO_000068: ncbigene

position:133721:-1
position: 133721
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:134134:-1
position: 134134
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133721-134134:-1:exon

YKL167C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL61
gene: MRP49
locus tag: YKL167C
gene synonym: mL61
product: mitochondrial 54S ribosomal protein MRP49
transcript id: NM_001179733.1
SIO_010081: YKL167C
subclass of: SO_0000673
so part of: YKL167C
location: complement(<133721..>134134)
location: region:133721-134134:-1
so has part: feature:133721-134134:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:133721-134134:-1:exon

YKL167C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL61
gene: MRP49
locus tag: YKL167C
gene synonym: mL61
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:1544898]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:1544898]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1544898]
note: Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation
codon start: 1
product: mitochondrial 54S ribosomal protein MRP49
translation: MSKVAQQLKFLNKISATTRLPQILVDPKKYSGLRLTFQTKNHNGHMGARVFWHNYLPTLQFYNPRMKFDVIRIKNEDKQKSVPCKLEILSHEGSVVETIDMRNKMHEDIMKDLLDKIEHVPLPENEIIRVGPQESII
SIO_010081: YKL167C
subclass of: SO_0000673
so part of: YKL167C
location: complement(133721..134134)
location: region:133721-134134:-1
so has part: feature:133721-134134:-1:exon

NP_012754.1
type: Protein
SIO_000068: ncbiprotein

S000001650
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:133721-134134:-1:exon

YKL166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPK3
locus tag: YKL166C
so part of: sequence
location: complement(<134509..>135705)
location: region:134509-135705:-1
so has part: feature:134509-135705:-1:exon
subclass of: SO_0000010

853688
type: Gene
SIO_000068: ncbigene

position:134509:-1
position: 134509
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135705:-1
position: 135705
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:134509-135705:-1:exon

YKL166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPK3
locus tag: YKL166C
product: cAMP-dependent protein kinase catalytic subunit TPK3
transcript id: NM_001179732.1
SIO_010081: YKL166C
subclass of: SO_0000673
so part of: YKL166C
location: complement(<134509..>135705)
location: region:134509-135705:-1
so has part: feature:134509-135705:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:134509-135705:-1:exon

YKL166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPK3
locus tag: YKL166C
EC number: 2.7.11.11
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:22899713]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19804918|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19804918|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:22899713]
experiment: EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]
experiment: EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]
experiment: EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:19897478]
experiment: EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]
experiment: EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]
experiment: EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]
experiment: EXISTENCE:mutant phenotype:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19897478]
experiment: EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:22899713]
note: cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
codon start: 1
product: cAMP-dependent protein kinase catalytic subunit TPK3
translation: MYVDPMNNNEIRKLSITAKTETTPDNVGQDIPVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLVKKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEEFNYGIQGEDPYMDLMKEF
SIO_010081: YKL166C
subclass of: SO_0000673
so part of: YKL166C
location: complement(134509..135705)
location: region:134509-135705:-1
so has part: feature:134509-135705:-1:exon

NP_012755.1
type: Protein
SIO_000068: ncbiprotein

S000001649
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:134509-135705:-1:exon

YKL165C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FSR2
alternative label: SSU21
alternative label: ZRG16
gene: MCD4
locus tag: YKL165C
gene synonym: FSR2; SSU21; ZRG16
so part of: sequence
location: complement(<137932..>140691)
location: region:137932-140691:-1
so has part: feature:137932-140691:-1:exon
subclass of: SO_0000010

853690
type: Gene
SIO_000068: ncbigene

position:137932:-1
position: 137932
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:140691:-1
position: 140691
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137932-140691:-1:exon

YKL165C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FSR2
alternative label: SSU21
alternative label: ZRG16
gene: MCD4
locus tag: YKL165C
gene synonym: FSR2; SSU21; ZRG16
product: mannose-ethanolamine phosphotransferase MCD4
transcript id: NM_001179731.1
SIO_010081: YKL165C
subclass of: SO_0000673
so part of: YKL165C
location: complement(<137932..>140691)
location: region:137932-140691:-1
so has part: feature:137932-140691:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:137932-140691:-1:exon

YKL165C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FSR2
alternative label: SSU21
alternative label: ZRG16
gene: MCD4
locus tag: YKL165C
gene synonym: FSR2; SSU21; ZRG16
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:10514566]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10069808|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:12023081]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:12023081]
experiment: EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:12807869]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17311586|PMID:16704983]
experiment: EXISTENCE:mutant phenotype:GO:0051377 mannose-ethanolamine phosphotransferase activity [PMID:17311586|PMID:16704983]
note: Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol
codon start: 1
product: mannose-ethanolamine phosphotransferase MCD4
translation: MWNKTRTTLLAVGVLFHLFYLWSIFDIYFISPLVHGMSPYQSTPTPPAKRLFLIVGDGLRADTTFDKVTHPVSGKTEFLAPFIRSLVMNNATYGISHTRMPTESRPGHVAMIAGFYEDVSAVTKGWKSNPVNFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFEDFTQSSIELDAFVFRHLDQLFHNSTLNSTLDYEIRQDGNVFFLHLLGCDTAGHSYRPYSAEYYDNVKYIDDQIPILIDKVNKFFADDKTAFIFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNKPVHNPFPVSDNYTENWELSSIKRNDVKQADIASLMSYLIGVNYPKNSVGELPIAYIDGKESDKLAALYNNARSILEQYLVKQDEVIDSQFFYKEYFKFVEKSHSHYLEEIETLIQRISEGENYLEQEAITLTEELMQITLEGLHYLTTYNWRFIRTIVTFGFVGWIFFSFIIFLKSFILENVIDDQKASPLSHAVFGSIGILLNWILFYQHSPFNFYMYLLFPLYFWSYIFTNRSVLRSGIKEFFKGTSPWKRVLITISIISVYEGIVYGFFHRWTFTLITNILAFYPFICGVRELSVNILWIITSVLLSTFTLFDAVKIEDLNQIHLAGLLIILSAFYALYKIHSRINSYTRAIFAIQISLVAAMLAVTHRSVISLQLRQGLPRESQVAGWIIFFVSLFVMPILHYRKPNNDYKVRLLIIYLTFAPSFIILTISFESLFYFLFTSYMVQWIEIENKIKEMKTQKDENWLQVLRVSVIGFFLLQVAFFGTGNVASISSFSLESVCRLLPIFDPFLMGALLMLKLIIPYGLLSTCLGILNLKLNFKDYTISSLIISMSDILSLNFFYLLRTEGSWLDIGITISNYCLAILSSLFMLILEVLGHVLLKNVIIQDKTKKTQ
SIO_010081: YKL165C
subclass of: SO_0000673
so part of: YKL165C
location: complement(137932..140691)
location: region:137932-140691:-1
so has part: feature:137932-140691:-1:exon

NP_012756.1
type: Protein
SIO_000068: ncbiprotein

S000001648
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:137932-140691:-1:exon

YNCK0005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0005C
so part of: sequence
location: complement(141018..141089)
location: region:141018-141089:-1
so has part: feature:141018-141089:-1:exon
subclass of: SO_0000663

853691
type: Gene
SIO_000068: ncbigene

position:141018:-1
position: 141018
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:141089:-1
position: 141089
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141018-141089:-1:exon

YNCK0005C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0005C
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCK0005C
subclass of: SO_0000673
so part of: YNCK0005C
location: complement(141018..141089)
location: region:141018-141089:-1
so has part: feature:141018-141089:-1:exon

S000006558
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141018-141089:-1:exon

YKL164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CCW6
gene: PIR1
locus tag: YKL164C
gene synonym: CCW6
so part of: sequence
location: complement(<141794..>142819)
location: region:141794-142819:-1
so has part: feature:141794-142819:-1:exon
subclass of: SO_0000010

853692
type: Gene
SIO_000068: ncbigene

position:141794:-1
position: 141794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:142819:-1
position: 142819
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141794-142819:-1:exon

YKL164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CCW6
gene: PIR1
locus tag: YKL164C
gene synonym: CCW6
product: beta-1,3-glucan linked protein
transcript id: NM_001179730.1
SIO_010081: YKL164C
subclass of: SO_0000673
so part of: YKL164C
location: complement(<141794..>142819)
location: region:141794-142819:-1
so has part: feature:141794-142819:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141794-142819:-1:exon

YKL164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CCW6
gene: PIR1
locus tag: YKL164C
gene synonym: CCW6
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:9301021]
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:16278454]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:9192695]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:11238901]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]
note: O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
codon start: 1
product: beta-1,3-glucan linked protein
translation: MQYKKSLVASALVATSLAAYAPKDPWSTLTPSATYKGGITDYSSTFGIAVEPIATTASSKAKRAAAISQIGDGQIQATTKTTAAAVSQIGDGQIQATTKTKAAAVSQIGDGQIQATTKTTSAKTTAAAVSQIGDGQIQATTKTKAAAVSQIGDGQIQATTKTTAAAVSQIGDGQIQATTKTTAAAVSQIGDGQIQATTNTTVAPVSQITDGQIQATTLTSATIIPSPAPAPITNGTDPVTAETCKSSGTLEMNLKGGILTDGKGRIGSIVANRQFQFDGPPPQAGAIYAAGWSITPEGNLAIGDQDTFYQCLSGNFYNLYDEHIGTQCNAVHLQAIDLLNC
SIO_010081: YKL164C
subclass of: SO_0000673
so part of: YKL164C
location: complement(141794..142819)
location: region:141794-142819:-1
so has part: feature:141794-142819:-1:exon

NP_012757.1
type: Protein
SIO_000068: ncbiprotein

S000001647
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141794-142819:-1:exon

YKL163W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CCW8
gene: PIR3
locus tag: YKL163W
gene synonym: CCW8
so part of: sequence
location: <144401..>145378
location: region:144401-145378:1
so has part: feature:144401-145378:1:exon
subclass of: SO_0000010

853693
type: Gene
SIO_000068: ncbigene

position:144401:1
position: 144401
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145378:1
position: 145378
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144401-145378:1:exon

YKL163W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CCW8
gene: PIR3
locus tag: YKL163W
gene synonym: CCW8
product: beta-1,3-glucan linked protein
transcript id: NM_001179729.1
SIO_010081: YKL163W
subclass of: SO_0000673
so part of: YKL163W
location: <144401..>145378
location: region:144401-145378:1
so has part: feature:144401-145378:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:144401-145378:1:exon

YKL163W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CCW8
gene: PIR3
locus tag: YKL163W
gene synonym: CCW8
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:10407261]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:9192695]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]
note: O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
codon start: 1
product: beta-1,3-glucan linked protein
translation: MQYKKPLVVSALAATSLAAYAPKDPWSTLTPSATYKGGITDYSSSFGIAIEAVATSASSVASSKAKRAASQIGDGQVQAATTTAAVSKKSTAAAVSQITDGQVQAAKSTAAAVSQITDGQVQAAKSTAAAVSQITDGQVQAAKSTAAAVSQITDGQVQAAKSTAAAASQISDGQVQATTSTKAAASQITDGQIQASKTTSGASQVSDGQVQATAEVKDANDPVDVVSCNNNSTLSMSLSKGILTDRKGRIGSIVANRQFQFDGPPPQAGAIYAAGWSITPEGNLALGDQDTFYQCLSGDFYNLYDKHIGSQCHEVYLQAIDLIDC
SIO_010081: YKL163W
subclass of: SO_0000673
so part of: YKL163W
location: 144401..145378
location: region:144401-145378:1
so has part: feature:144401-145378:1:exon

NP_012758.1
type: Protein
SIO_000068: ncbiprotein

S000001646
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:144401-145378:1:exon

YKL162C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL162C
so part of: sequence
location: complement(<147630..>148838)
location: region:147630-148838:-1
so has part: feature:147630-148838:-1:exon
subclass of: SO_0000010

853695
type: Gene
SIO_000068: ncbigene

position:147630:-1
position: 147630
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148838:-1
position: 148838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:147630-148838:-1:exon

YKL162C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL162C
product: type II protein arginine methyltransferase
transcript id: NM_001179728.1
SIO_010081: YKL162C
subclass of: SO_0000673
so part of: YKL162C
location: complement(<147630..>148838)
location: region:147630-148838:-1
so has part: feature:147630-148838:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:147630-148838:-1:exon

YKL162C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL162C
EC number: 2.1.1.320
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
codon start: 1
product: type II protein arginine methyltransferase
translation: MMKRLHPLRIQVHLKSDYPLFTFEQLLSTNGIRRGQTARISLKDYIEWQNFPNIMKRENFFTQRKPVTTTAKEEPFSFDNILDCEPQFSKCLAKWLLVNYKLNDYPYYDLNIVNIYTDLPQAIQICKNLMSYLKSTLSDNMFQKIKYFMVPLYKCDKIPSKLLDGIPGSVSLVQDYPVSPYFLQKKFHIEDPIQILMLNDVIKYTTHDLVRYSSDDKGWQQCFVDINKNGQKSKSFDSAIDYSCELALEQMFNDRSHVSPGKELYIPTKLIEILMTIKNNIPEHRLFIVDTPQRSSPTIISLLKSLISPRPTGSSQIVQPYSDSIFSDKRSGRICFMTDFLQLQNIYNGINSSSSSCEVEDVADFVEKWISPSERSTLSSQNGNRPQLEDIKNSSLAVLHST
SIO_010081: YKL162C
subclass of: SO_0000673
so part of: YKL162C
location: complement(147630..148838)
location: region:147630-148838:-1
so has part: feature:147630-148838:-1:exon

NP_012760.1
type: Protein
SIO_000068: ncbiprotein

S000001645
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:147630-148838:-1:exon

YKL161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MLP1
gene: KDX1
locus tag: YKL161C
gene synonym: MLP1
so part of: sequence
location: complement(<149386..>150687)
location: region:149386-150687:-1
so has part: feature:149386-150687:-1:exon
subclass of: SO_0000010

853696
type: Gene
SIO_000068: ncbigene

position:149386:-1
position: 149386
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150687:-1
position: 150687
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:149386-150687:-1:exon

YKL161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MLP1
gene: KDX1
locus tag: YKL161C
gene synonym: MLP1
product: putative protein kinase KDX1
transcript id: NM_001179727.1
SIO_010081: YKL161C
subclass of: SO_0000673
so part of: YKL161C
location: complement(<149386..>150687)
location: region:149386-150687:-1
so has part: feature:149386-150687:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:149386-150687:-1:exon

YKL161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MLP1
gene: KDX1
locus tag: YKL161C
gene synonym: MLP1
EC number: 2.7.11.1
note: Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication
codon start: 1
product: putative protein kinase KDX1
translation: MATDTERCIFRAFGQDFILNKHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQEIASQKVYNYIFQFGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPYLSMWHDIDEEFSCQKTFRFEFEHIESMAELGNEVIKEVFDFRKVVRKHPISGDSPSSSLSLEDAIPQEVVQVHPSRKVLPSYSPEFSYVSQLPSLTTTQPYQNLMGISSNSFQGVN
SIO_010081: YKL161C
subclass of: SO_0000673
so part of: YKL161C
location: complement(149386..150687)
location: region:149386-150687:-1
so has part: feature:149386-150687:-1:exon

NP_012761.1
type: Protein
SIO_000068: ncbiprotein

S000001644
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:149386-150687:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1106; Autonomously Replicating Sequence
so part of: sequence
location: 153020..153135
location: region:153020-153135:1
so has part: feature:153020-153135:1:region

S000118402
type: SGD
SIO_000068: sgd

position:153020:1
position: 153020
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:153135:1
position: 153135
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153020-153135:1:region

YKL160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ELF1
locus tag: YKL160W
so part of: sequence
location: <153269..>153706
location: region:153269-153706:1
so has part: feature:153269-153706:1:exon
subclass of: SO_0000010

853697
type: Gene
SIO_000068: ncbigene

position:153269:1
position: 153269
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:153706:1
position: 153706
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153269-153706:1:exon

YKL160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ELF1
locus tag: YKL160W
product: Elf1p
transcript id: NM_001179726.1
SIO_010081: YKL160W
subclass of: SO_0000673
so part of: YKL160W
location: <153269..>153706
location: region:153269-153706:1
so has part: feature:153269-153706:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153269-153706:1:exon

YKL160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ELF1
locus tag: YKL160W
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:20818391]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19159085|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008023 transcription elongation factor complex [PMID:20818391]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:16260625]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:16260625]
experiment: EXISTENCE:mutant phenotype:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:16260625]
note: Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
codon start: 1
product: Elf1p
translation: MGKRKKSTRKPTKRLVQKLDTKFNCLFCNHEKSVSCTLDKKNSIGTLSCKICGQSFQTRINSLSQPVDVYSDWFDAVEEVNSGRGSDTDDGDEGSDSDYESDSEQDAKTQNDGEIDSDEEEVDSDEERIGQVKRGRGALVDSDDE
SIO_010081: YKL160W
subclass of: SO_0000673
so part of: YKL160W
location: 153269..153706
location: region:153269-153706:1
so has part: feature:153269-153706:1:exon

NP_012762.1
type: Protein
SIO_000068: ncbiprotein

S000001643
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153269-153706:1:exon

YKL159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCN1
locus tag: YKL159C
so part of: sequence
location: complement(<153816..>154451)
location: region:153816-154451:-1
so has part: feature:153816-154451:-1:exon
subclass of: SO_0000010

853698
type: Gene
SIO_000068: ncbigene

position:153816:-1
position: 153816
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:154451:-1
position: 154451
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153816-154451:-1:exon

YKL159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCN1
locus tag: YKL159C
product: Rcn1p
transcript id: NM_001179725.1
SIO_010081: YKL159C
subclass of: SO_0000673
so part of: YKL159C
location: complement(<153816..>154451)
location: region:153816-154451:-1
so has part: feature:153816-154451:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153816-154451:-1:exon

YKL159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCN1
locus tag: YKL159C
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:10887154]
experiment: EXISTENCE:direct assay:GO:0030346 protein phosphatase 2B binding [PMID:10887154]
experiment: EXISTENCE:mutant phenotype:GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity [PMID:10887154]
experiment: EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:17954914]
note: Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
codon start: 1
product: Rcn1p
translation: MGNIITDTIIITSDKCDIVDNDNVERIQVWLSKNILRKFQINENEPLQLIILKRFKRILLICPSHDISQHVMDASRALEMENFNFSYSLQDGQRNLTKQYLKVPESEKMFLISPPASPPPEFDFSKCEDAPQRHIQSHIQQDQQQRLEASQLLPNNPDKNNNGTFTLLKSKVGAITIDRCPTNDGNGQMQLADHVKTAFPPKSIFDTDDDD
SIO_010081: YKL159C
subclass of: SO_0000673
so part of: YKL159C
location: complement(153816..154451)
location: region:153816-154451:-1
so has part: feature:153816-154451:-1:exon

NP_012763.1
type: Protein
SIO_000068: ncbiprotein

S000001642
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153816-154451:-1:exon

YKL157W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LAP1
alternative label: YKL158W
gene: APE2
locus tag: YKL157W
gene synonym: LAP1; YKL158W
so part of: sequence
location: <154991..>158232
location: region:154991-158232:1
so has part: feature:154991-158232:1:exon
subclass of: SO_0000010

853699
type: Gene
SIO_000068: ncbigene

position:154991:1
position: 154991
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:158232:1
position: 158232
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:154991-158232:1:exon

YKL157W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LAP1
alternative label: YKL158W
gene: APE2
locus tag: YKL157W
gene synonym: LAP1; YKL158W
product: metallo-aminopeptidase
transcript id: NM_001179723.2
SIO_010081: YKL157W
subclass of: SO_0000673
so part of: YKL157W
location: join(<154991..155271,155655..>158232)
location: region:154991-158232:1
so has part: feature:154991-155271:1:exon
so has part: feature:155655-158232:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:154991-155271:1:exon

position:155271:1
position: 155271
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:155655-158232:1:exon

position:155655:1
position: 155655
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL157W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LAP1
alternative label: YKL158W
gene: APE2
locus tag: YKL157W
gene synonym: LAP1; YKL158W
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:383482]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:383482]
experiment: EXISTENCE:direct assay:GO:0043171 peptide catabolic process [PMID:6352682]
experiment: EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:6352682]
experiment: EXISTENCE:mutant phenotype:GO:0043171 peptide catabolic process [PMID:3286257]
note: Aminopeptidase yscII; may have role in obtaining leucine from dipeptide substrates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; APE2 has a paralog, AAP1, that arose from the whole genome duplication
codon start: 1
product: metallo-aminopeptidase
translation: MPIVRWLLLKSAVRGSSLIGKAHPCLRSIAAHPRYLSNVYSPPAGVSRSLRINVMWKQSKLTPPRFVKIMNRRPLFTETSHACAKCQKTSQLLNKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTLFNTTPKMSTYLVAFIVAELKYVESKNFRIPVRVYATPGNEKHGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNIWTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWVNRDRDVVNKYLKENGYY
SIO_010081: YKL157W
subclass of: SO_0000673
so part of: YKL157W
location: join(154991..155271,155655..158232)
location: region:154991-158232:1
so has part: feature:154991-155271:1:exon
so has part: feature:155655-158232:1:exon

NP_012765.3
type: Protein
SIO_000068: ncbiprotein

S000001640
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:154991-155271:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:155655-158232:1:exon

YKL156W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS27A
locus tag: YKL156W
so part of: sequence
location: <158613..>159212
location: region:158613-159212:1
so has part: feature:158613-159212:1:exon
subclass of: SO_0000010

853700
type: Gene
SIO_000068: ncbigene

position:158613:1
position: 158613
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159212:1
position: 159212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:158613-159212:1:exon

YKL156W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS27A
locus tag: YKL156W
product: ribosomal 40S subunit protein S27A
transcript id: NM_001179722.1
SIO_010081: YKL156W
subclass of: SO_0000673
so part of: YKL156W
location: join(<158613..158615,158967..>159212)
location: region:158613-159212:1
so has part: feature:158613-158615:1:exon
so has part: feature:158967-159212:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:158613-158615:1:exon

position:158615:1
position: 158615
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:158967-159212:1:exon

position:158967:1
position: 158967
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL156W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS27A
locus tag: YKL156W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9271380]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: ribosomal 40S subunit protein S27A
translation: MVLVQDLLHPTAASEARKHKLKTLVQGPRSYFLDVKCPGCLNITTVFSHAQTAVTCESCSTILCTPTGGKAKLSEGTSFRRK
SIO_010081: YKL156W
subclass of: SO_0000673
so part of: YKL156W
location: join(158613..158615,158967..159212)
location: region:158613-159212:1
so has part: feature:158613-158615:1:exon
so has part: feature:158967-159212:1:exon

NP_012766.1
type: Protein
SIO_000068: ncbiprotein

S000001639
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:158613-158615:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:158967-159212:1:exon

YKL155C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSM22
locus tag: YKL155C
so part of: sequence
location: complement(<159456..>161342)
location: region:159456-161342:-1
so has part: feature:159456-161342:-1:exon
subclass of: SO_0000010

853701
type: Gene
SIO_000068: ncbigene

position:159456:-1
position: 159456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:161342:-1
position: 161342
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159456-161342:-1:exon

YKL155C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSM22
locus tag: YKL155C
product: mitochondrial 37S ribosomal protein RSM22
transcript id: NM_001179721.1
SIO_010081: YKL155C
subclass of: SO_0000673
so part of: YKL155C
location: complement(<159456..>161342)
location: region:159456-161342:-1
so has part: feature:159456-161342:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159456-161342:-1:exon

YKL155C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSM22
locus tag: YKL155C
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase
codon start: 1
product: mitochondrial 37S ribosomal protein RSM22
translation: MMKRCFSILPQNVRFSSKFTSLNLPKLDLADFIDSNKRGINVLPSYRDETASTTQATNSKELRLLSKTLQGQSYRDQLELNPDVSKAINNNIMAVHIPNNLRRVATNYYKEIQEPNSLHRPCRTKMEVDAHIASIFLQNYGSIFQSLKELQKRVGPDNFKPQRILDVGYGPATGIVALNDILGPNYRPDLKDAVILGNAEMQERAKIILSRQLNEVVDTVEENVSTEKEQETDRRNKNFQEDEHIGEVMTKKINIMTNLRSSIPASKEYDLIILTHQLLHDGNQFPIQVDENIEHYLNILAPGGHIVIIERGNPMGFEIIARARQITLRPENFPDEFGKIPRPWSRGVTVRGKKDAELGNISSNYFLKVIAPCPHQRKCPLQVGNPNFYTHKEGKDLKFCNFQKSIKRPKFSIELKKGKLLATSWDGSQGNASRLKGTGRRNGRDYEILNYSYLIFERSHKDENTLKEIKKLRNENVNGKYDIGSLGDDTQNSWPRIINDPVKRKGHVMMDLCAPSGELEKWTVSRSFSKQIYHDARKSKKGDLWASAAKTQIKGLGDLNVKKFHKLEKERIKQLKKEERQKARKAMESYNELEDSLQFDDHQFSNFEVMKKLSTFHGNDFLQHVNRK
SIO_010081: YKL155C
subclass of: SO_0000673
so part of: YKL155C
location: complement(159456..161342)
location: region:159456-161342:-1
so has part: feature:159456-161342:-1:exon

NP_012767.1
type: Protein
SIO_000068: ncbiprotein

S000001638
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159456-161342:-1:exon

YKL154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRP102
locus tag: YKL154W
so part of: sequence
location: <161601..>162335
location: region:161601-162335:1
so has part: feature:161601-162335:1:exon
subclass of: SO_0000010

853702
type: Gene
SIO_000068: ncbigene

position:161601:1
position: 161601
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:162335:1
position: 162335
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:161601-162335:1:exon

YKL154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRP102
locus tag: YKL154W
product: Signal recognition particle receptor subunit beta
transcript id: NM_001179720.1
SIO_010081: YKL154W
subclass of: SO_0000673
so part of: YKL154W
location: <161601..>162335
location: region:161601-162335:1
so has part: feature:161601-162335:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:161601-162335:1:exon

YKL154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRP102
locus tag: YKL154W
experiment: EXISTENCE:curator inference:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:7844142]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9679135]
experiment: EXISTENCE:mutant phenotype:GO:0005047 signal recognition particle binding [PMID:9679135]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:9679135]
experiment: EXISTENCE:physical interaction:GO:0005785 signal recognition particle receptor complex [PMID:9679135]
note: Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
codon start: 1
product: Signal recognition particle receptor subunit beta
translation: MLSNTLIIACLLVIGTTIALIAVQKASSKTGIKQKSYQPSIIIAGPQNSGKTSLLTLLTTDSVRPTVVSQEPLSAADYDGSGVTLVDFPGHVKLRYKLSDYLKTRAKFVKGLIFMVDSTVDPKKLTTTAEFLVDILSITESSCENGIDILIACNKSELFTARPPSKIKDALESEIQKVIERRKKSLNEVERKINEEDYAENTLDVLQSTDGFKFANLEASVVAFEGSINKRKISQWREWIDEKL
SIO_010081: YKL154W
subclass of: SO_0000673
so part of: YKL154W
location: 161601..162335
location: region:161601-162335:1
so has part: feature:161601-162335:1:exon

NP_012768.1
type: Protein
SIO_000068: ncbiprotein

S000001637
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:161601-162335:1:exon

YNCK0006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0006C
so part of: sequence
location: complement(162487..162558)
location: region:162487-162558:-1
so has part: feature:162487-162558:-1:exon
subclass of: SO_0000663

853703
type: Gene
SIO_000068: ncbigene

position:162487:-1
position: 162487
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:162558:-1
position: 162558
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:162487-162558:-1:exon

YNCK0006C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0006C
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCK0006C
subclass of: SO_0000673
so part of: YNCK0006C
location: complement(162487..162558)
location: region:162487-162558:-1
so has part: feature:162487-162558:-1:exon

S000006716
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:162487-162558:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 162831..163169
location: region:162831-163169:1
so has part: feature:162831-163169:1:region

S000007056
type: SGD
SIO_000068: sgd

position:162831:1
position: 162831
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:163169:1
position: 163169
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:162831-163169:1:region

YKL152C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPM1
locus tag: YKL152C
so part of: sequence
location: complement(<163642..>164385)
location: region:163642-164385:-1
so has part: feature:163642-164385:-1:exon
subclass of: SO_0000010

853705
type: Gene
SIO_000068: ncbigene

position:163642:-1
position: 163642
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164385:-1
position: 164385
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:163642-164385:-1:exon

YKL152C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPM1
locus tag: YKL152C
product: phosphoglycerate mutase GPM1
transcript id: NM_001179718.1
SIO_010081: YKL152C
subclass of: SO_0000673
so part of: YKL152C
location: complement(<163642..>164385)
location: region:163642-164385:-1
so has part: feature:163642-164385:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:163642-164385:-1:exon

YKL152C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPM1
locus tag: YKL152C
EC number: 5.4.2.11
experiment: EXISTENCE:direct assay:GO:0004619 phosphoglycerate mutase activity [PMID:1386023]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3332961]
experiment: EXISTENCE:mutant phenotype:GO:0004619 phosphoglycerate mutase activity [PMID:3033435]
experiment: EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:3033435]
experiment: EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:11015729]
note: Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
codon start: 1
product: phosphoglycerate mutase GPM1
translation: MPKLVLVRHGQSEWNEKNLFTGWVDVKLSAKGQQEAARAGELLKEKKVYPDVLYTSKLSRAIQTANIALEKADRLWIPVNRSWRLNERHYGDLQGKDKAETLKKFGEEKFNTYRRSFDVPPPPIDASSPFSQKGDERYKYVDPNVLPETESLALVIDRLLPYWQDVIAKDLLSGKTVMIAAHGNSLRGLVKHLEGISDADIAKLNIPTGIPLVFELDENLKPSKPSYYLDPEAAAAGAAAVANQGKK
SIO_010081: YKL152C
subclass of: SO_0000673
so part of: YKL152C
location: complement(163642..164385)
location: region:163642-164385:-1
so has part: feature:163642-164385:-1:exon

NP_012770.1
type: Protein
SIO_000068: ncbiprotein

S000001635
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:163642-164385:-1:exon

YKL151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NNR2
locus tag: YKL151C
so part of: sequence
location: complement(<164917..>165930)
location: region:164917-165930:-1
so has part: feature:164917-165930:-1:exon
subclass of: SO_0000010

853706
type: Gene
SIO_000068: ncbigene

position:164917:-1
position: 164917
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:165930:-1
position: 165930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164917-165930:-1:exon

YKL151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NNR2
locus tag: YKL151C
product: NADHX dehydratase
transcript id: NM_001179717.1
SIO_010081: YKL151C
subclass of: SO_0000673
so part of: YKL151C
location: complement(<164917..>165930)
location: region:164917-165930:-1
so has part: feature:164917-165930:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164917-165930:-1:exon

YKL151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NNR2
locus tag: YKL151C
EC number: 4.2.1.93
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21994945]
experiment: EXISTENCE:direct assay:GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity [PMID:21994945]
note: Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli
codon start: 1
product: NADHX dehydratase
translation: MLAELSHRELIKLAQKRCIPPLLPKFHKGQSGGRVCIIGGCEDYTGAPYFSANATALMGCDLTHVICEYNAGTVIKSYTPNLMVHPYLRMSNTKLDVDMDEQRKKINSLLDRIHVVVIGPGLGRDPLMLKSIKDIIRYILEKHEGKIPLVIDADGLFLVTQDSEVKEMLKSYPKGRVILTPNVVEFKRLCDAIGKKGDSHSEMGSLIAQELNCIVVEKGQSDKIFSPDSEKDMLTNSEEGSNKRVGGQGDTLTGAISCMLAFSRAMYDFKICEQEEKGESSNDKPLKNWVDYAMLSCYAGCTITRECSRLGFKAKGRAMQTTDLNDRVGEVFAKLFG
SIO_010081: YKL151C
subclass of: SO_0000673
so part of: YKL151C
location: complement(164917..165930)
location: region:164917-165930:-1
so has part: feature:164917-165930:-1:exon

NP_012771.1
type: Protein
SIO_000068: ncbiprotein

S000001634
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164917-165930:-1:exon

YKL150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCR1
locus tag: YKL150W
so part of: sequence
location: <166544..>167452
location: region:166544-167452:1
so has part: feature:166544-167452:1:exon
subclass of: SO_0000010

853707
type: Gene
SIO_000068: ncbigene

position:166544:1
position: 166544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167452:1
position: 167452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:166544-167452:1:exon

YKL150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCR1
locus tag: YKL150W
product: cytochrome-b5 reductase
transcript id: NM_001179716.1
SIO_010081: YKL150W
subclass of: SO_0000673
so part of: YKL150W
location: <166544..>167452
location: region:166544-167452:1
so has part: feature:166544-167452:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:166544-167452:1:exon

YKL150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCR1
locus tag: YKL150W
EC number: 1.6.2.2
experiment: EXISTENCE:direct assay:GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H [PMID:8001120]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:8001120|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:8001120]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:10622712]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11420140]
note: Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis
codon start: 1
product: cytochrome-b5 reductase
translation: MFSRLSRSHSKALPIALGTVAIAAATAFYFANRNQHSFVFNESNKVFKGDDKWIDLPISKIEEESHDTRRFTFKLPTEDSEMGLVLASALFAKFVTPKGSNVVRPYTPVSDLSQKGHFQLVVKHYEGGKMTSHLFGLKPNDTVSFKGPIMKWKWQPNQFKSITLLGAGTGINPLYQLAHHIVENPNDKTKVNLLYGNKTPQDILLRKELDALKEKYPDKFNVTYFVDDKQDDQDFDGEISFISKDFIQEHVPGPKESTHLFVCGPPPFMNAYSGEKKSPKDQGELIGILNNLGYSKDQVFKF
SIO_010081: YKL150W
subclass of: SO_0000673
so part of: YKL150W
location: 166544..167452
location: region:166544-167452:1
so has part: feature:166544-167452:1:exon

NP_012772.1
type: Protein
SIO_000068: ncbiprotein

S000001633
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:166544-167452:1:exon

YKL149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PRP26
gene: DBR1
locus tag: YKL149C
gene synonym: PRP26
so part of: sequence
location: complement(<167612..>168829)
location: region:167612-168829:-1
so has part: feature:167612-168829:-1:exon
subclass of: SO_0000010

853708
type: Gene
SIO_000068: ncbigene

position:167612:-1
position: 167612
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:168829:-1
position: 168829
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167612-168829:-1:exon

YKL149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PRP26
gene: DBR1
locus tag: YKL149C
gene synonym: PRP26
product: RNA lariat debranching enzyme
transcript id: NM_001179715.1
SIO_010081: YKL149C
subclass of: SO_0000673
so part of: YKL149C
location: complement(<167612..>168829)
location: region:167612-168829:-1
so has part: feature:167612-168829:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167612-168829:-1:exon

YKL149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PRP26
gene: DBR1
locus tag: YKL149C
gene synonym: PRP26
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:1850323]
experiment: EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:1850323]
experiment: EXISTENCE:direct assay:GO:0008419 RNA lariat debranching enzyme activity [PMID:1850323]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:24919400]
experiment: EXISTENCE:mutant phenotype:GO:0006401 RNA catabolic process [PMID:1850323]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0008419 RNA lariat debranching enzyme activity [PMID:1850323]
experiment: EXISTENCE:mutant phenotype:GO:0016074 sno(s)RNA metabolic process [PMID:9740128]
experiment: EXISTENCE:mutant phenotype:GO:0032197 transposition, RNA-mediated [PMID:10652222]
note: RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant
codon start: 1
product: RNA lariat debranching enzyme
translation: MTKLRIAVQGCCHGQLNQIYKEVSRIHAKTPIDLLIILGDFQSIRDGQDFKSIAIPPKYQRLGDFISYYNNEIEAPVPTIFIGGNHESMRHLMLLPHGGYVAKNIFYMGYSNVIWFKGIRIGSLSGIWKEWDFNKQRPDWNDLENNNWKANIRNLYHVRISDIAPLFMIKHRIDIMLSHDWPNGVVYHGDTKHLLKLKPFFEQDIKEGKLGSPVTWQLLRDLRPQWWLSAHLHVRFMASIKHNKRSHEPPNKSTSKTKKNNNEIDLDLSSDEDERSGIMNCQEENEYDSKYGETRFLALDKCLPRRRWLEILEIEPDTSHASWKDENHRMFWDPEFINNLVICQKNKNLLSNKPFNSVNWIELSQSNREEGRDIDWENYAIPAYTLDIQKDEVRQTKAFISKFMT
SIO_010081: YKL149C
subclass of: SO_0000673
so part of: YKL149C
location: complement(167612..168829)
location: region:167612-168829:-1
so has part: feature:167612-168829:-1:exon

NP_012773.1
type: Protein
SIO_000068: ncbiprotein

S000001632
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167612-168829:-1:exon

YKL148C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDH1
locus tag: YKL148C
so part of: sequence
location: complement(<169207..>171129)
location: region:169207-171129:-1
so has part: feature:169207-171129:-1:exon
subclass of: SO_0000010

853709
type: Gene
SIO_000068: ncbigene

position:169207:-1
position: 169207
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171129:-1
position: 171129
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:169207-171129:-1:exon

YKL148C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDH1
locus tag: YKL148C
product: succinate dehydrogenase flavoprotein subunit SDH1
transcript id: NM_001179714.1
SIO_010081: YKL148C
subclass of: SO_0000673
so part of: YKL148C
location: complement(<169207..>171129)
location: region:169207-171129:-1
so has part: feature:169207-171129:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:169207-171129:-1:exon

YKL148C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDH1
locus tag: YKL148C
EC number: 1.3.5.1
experiment: EXISTENCE:curator inference:GO:0006099 tricarboxylic acid cycle [PMID:13445213]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2826438|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [PMID:9822678]
experiment: EXISTENCE:direct assay:GO:0006121 mitochondrial electron transport, succinate to ubiquinone [PMID:2826438]
experiment: EXISTENCE:direct assay:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:13445213]
experiment: EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:1939170]
experiment: EXISTENCE:direct assay:GO:0050660 flavin adenine dinucleotide binding [PMID:18279395]
experiment: EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:16232921]
experiment: EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:16232921|PMID:9730279]
experiment: EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:16232921|PMID:197391|PMID:9730279]
experiment: EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921|PMID:9730279]
experiment: EXISTENCE:mutant phenotype:GO:0050660 flavin adenine dinucleotide binding [PMID:1939170]
note: Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers
codon start: 1
product: succinate dehydrogenase flavoprotein subunit SDH1
translation: MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY
SIO_010081: YKL148C
subclass of: SO_0000673
so part of: YKL148C
location: complement(169207..171129)
location: region:169207-171129:-1
so has part: feature:169207-171129:-1:exon

NP_012774.1
type: Protein
SIO_000068: ncbiprotein

S000001631
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:169207-171129:-1:exon

YKL146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVT3
locus tag: YKL146W
so part of: sequence
location: <171783..>173861
location: region:171783-173861:1
so has part: feature:171783-173861:1:exon
subclass of: SO_0000010

853710
type: Gene
SIO_000068: ncbigene

position:171783:1
position: 171783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:173861:1
position: 173861
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171783-173861:1:exon

YKL146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVT3
locus tag: YKL146W
product: Avt3p
transcript id: NM_001179712.1
SIO_010081: YKL146W
subclass of: SO_0000673
so part of: YKL146W
location: <171783..>173861
location: region:171783-173861:1
so has part: feature:171783-173861:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171783-173861:1:exon

YKL146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVT3
locus tag: YKL146W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:27246536]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:genetic interaction:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:27246536]
experiment: EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]
note: Vacuolar transporter; exports large neutral amino acids from vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
codon start: 1
product: Avt3p
translation: MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSGTTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSNSLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASIASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFFTRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGYGDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFGSDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGTSRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ
SIO_010081: YKL146W
subclass of: SO_0000673
so part of: YKL146W
location: 171783..173861
location: region:171783-173861:1
so has part: feature:171783-173861:1:exon

NP_012776.1
type: Protein
SIO_000068: ncbiprotein

S000001629
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171783-173861:1:exon

YKL145W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CIM5
alternative label: YTA3
gene: RPT1
locus tag: YKL145W
gene synonym: CIM5; YTA3
so part of: sequence
location: <174213..>175616
location: region:174213-175616:1
so has part: feature:174213-175616:1:exon
subclass of: SO_0000010

853712
type: Gene
SIO_000068: ncbigene

position:174213:1
position: 174213
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:175616:1
position: 175616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:174213-175616:1:exon

YKL145W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CIM5
alternative label: YTA3
gene: RPT1
locus tag: YKL145W
gene synonym: CIM5; YTA3
product: proteasome regulatory particle base subunit RPT1
transcript id: NM_001179711.1
SIO_010081: YKL145W
subclass of: SO_0000673
so part of: YKL145W
location: <174213..>175616
location: region:174213-175616:1
so has part: feature:174213-175616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:174213-175616:1:exon

YKL145W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CIM5
alternative label: YTA3
gene: RPT1
locus tag: YKL145W
gene synonym: CIM5; YTA3
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:15135049]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]
experiment: EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]
experiment: EXISTENCE:physical interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15135049]
experiment: EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:10688918]
note: ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
codon start: 1
product: proteasome regulatory particle base subunit RPT1
translation: MPPKEDWEKYKAPLEDDDKKPDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADEDDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRYMQYN
SIO_010081: YKL145W
subclass of: SO_0000673
so part of: YKL145W
location: 174213..175616
location: region:174213-175616:1
so has part: feature:174213-175616:1:exon

NP_012777.1
type: Protein
SIO_000068: ncbiprotein

S000001628
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:174213-175616:1:exon

YKL144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKL1
gene: RPC25
locus tag: YKL144C
gene synonym: YKL1
so part of: sequence
location: complement(<175843..>176481)
location: region:175843-176481:-1
so has part: feature:175843-176481:-1:exon
subclass of: SO_0000010

853713
type: Gene
SIO_000068: ncbigene

position:175843:-1
position: 175843
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:176481:-1
position: 176481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175843-176481:-1:exon

YKL144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKL1
gene: RPC25
locus tag: YKL144C
gene synonym: YKL1
product: DNA-directed RNA polymerase III subunit RPC25
transcript id: NM_001179710.1
SIO_010081: YKL144C
subclass of: SO_0000673
so part of: YKL144C
location: complement(<175843..>176481)
location: region:175843-176481:-1
so has part: feature:175843-176481:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175843-176481:-1:exon

YKL144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKL1
gene: RPC25
locus tag: YKL144C
gene synonym: YKL1
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:mutant phenotype:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:15612920]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:15612920|PMID:8065349]
note: RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
codon start: 1
product: DNA-directed RNA polymerase III subunit RPC25
translation: MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLKPGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYYTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEGKNEETPQNEKPPAYALLGSCQTDGMGLVSWWE
SIO_010081: YKL144C
subclass of: SO_0000673
so part of: YKL144C
location: complement(175843..176481)
location: region:175843-176481:-1
so has part: feature:175843-176481:-1:exon

NP_012778.1
type: Protein
SIO_000068: ncbiprotein

S000001627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175843-176481:-1:exon

YKL143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKL2
gene: LTV1
locus tag: YKL143W
gene synonym: YKL2
so part of: sequence
location: <176781..>178172
location: region:176781-178172:1
so has part: feature:176781-178172:1:exon
subclass of: SO_0000010

853714
type: Gene
SIO_000068: ncbigene

position:176781:1
position: 176781
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:178172:1
position: 178172
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:176781-178172:1:exon

YKL143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKL2
gene: LTV1
locus tag: YKL143W
gene synonym: YKL2
product: Ltv1p
transcript id: NM_001179709.1
SIO_010081: YKL143W
subclass of: SO_0000673
so part of: YKL143W
location: <176781..>178172
location: region:176781-178172:1
so has part: feature:176781-178172:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:176781-178172:1:exon

YKL143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKL2
gene: LTV1
locus tag: YKL143W
gene synonym: YKL2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16888326]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16888326|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661|PMID:15167894]
experiment: EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]
experiment: EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]
experiment: EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:16888326]
experiment: EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:16888326]
experiment: EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:15611164]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15611164]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
note: Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; required for ribosomal small subunit export from nucleus; required for growth at low temperature
codon start: 1
product: Ltv1p
translation: MSKKFSSKNSQRYVVVHRPHDDPSFYDTDASAHVLVPVSNPNKTSPEADLRKKDVSSTKPKGRRAHVGEAALYGINFDDSEYDYTQHLKPIGLDPENSIFIASKGNEQKVEKKNIEDLFIEPKYRRDEIEKDDALPVFQRGMAKPEYLLHQQDTTDEIRGFKPDMNPALREVLEALEDEAYVVNDDVVVEDISKKTQLQGDNYGEEEKEDDIFAQLLGSGEAKDEDEFEDEFDEWDIDNVENFEDENYVKEMAQFDNIENLEDLENIDYQADVRRFQKDNSILEKHNSDDEFSNAGLDSVNPSEEEDVLGELPSIQDKSKTGKKKRKSRQKKGAMSDVSGFSMSSSAIARTETMTVLDDQYDQIINGYENYEEELEEDEEQNYQPFDMSAERSDFESMLDDFLDNYELESGGRKLAKKDKEIERLKEAADEVSKGKLSQRRNRERQEKKKLEKVTNTLSSLKF
SIO_010081: YKL143W
subclass of: SO_0000673
so part of: YKL143W
location: 176781..178172
location: region:176781-178172:1
so has part: feature:176781-178172:1:exon

NP_012779.1
type: Protein
SIO_000068: ncbiprotein

S000001626
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:176781-178172:1:exon

YKL142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKL3
gene: MRP8
locus tag: YKL142W
gene synonym: YKL3
so part of: sequence
location: <178515..>179174
location: region:178515-179174:1
so has part: feature:178515-179174:1:exon
subclass of: SO_0000010

853715
type: Gene
SIO_000068: ncbigene

position:178515:1
position: 178515
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:179174:1
position: 179174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178515-179174:1:exon

YKL142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKL3
gene: MRP8
locus tag: YKL142W
gene synonym: YKL3
product: Mrp8p
transcript id: NM_001179708.1
SIO_010081: YKL142W
subclass of: SO_0000673
so part of: YKL142W
location: <178515..>179174
location: region:178515-179174:1
so has part: feature:178515-179174:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178515-179174:1:exon

YKL142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKL3
gene: MRP8
locus tag: YKL142W
gene synonym: YKL3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
codon start: 1
product: Mrp8p
translation: MSNEIELLQKQVSELQDLVKKQSLIISKTGERVLELQLDKQKHDVTDFDSKFSKSISKKSGSATQFDATDFATNEDLVELVKELQGELNFIEERSIRRLVNSLKKDDDDVIAPLPNADGDIPAISDGVFPKSLKEFKDIPDLKLVRLAKFYERLPPTLKEQEDFENFLEGKVEAFHINETTDEEISKELEKFSKDELDDAFNDVARYLGLSLRRGTEIW
SIO_010081: YKL142W
subclass of: SO_0000673
so part of: YKL142W
location: 178515..179174
location: region:178515-179174:1
so has part: feature:178515-179174:1:exon

NP_012780.1
type: Protein
SIO_000068: ncbiprotein

S000001625
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178515-179174:1:exon

YKL141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYB3
alternative label: YKL4
gene: SDH3
locus tag: YKL141W
gene synonym: CYB3; YKL4
so part of: sequence
location: <179667..>180263
location: region:179667-180263:1
so has part: feature:179667-180263:1:exon
subclass of: SO_0000010

853716
type: Gene
SIO_000068: ncbigene

position:179667:1
position: 179667
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:180263:1
position: 180263
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:179667-180263:1:exon

YKL141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYB3
alternative label: YKL4
gene: SDH3
locus tag: YKL141W
gene synonym: CYB3; YKL4
product: succinate dehydrogenase cytochrome b subunit SDH3
transcript id: NM_001179707.1
SIO_010081: YKL141W
subclass of: SO_0000673
so part of: YKL141W
location: <179667..>180263
location: region:179667-180263:1
so has part: feature:179667-180263:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:179667-180263:1:exon

YKL141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYB3
alternative label: YKL4
gene: SDH3
locus tag: YKL141W
gene synonym: CYB3; YKL4
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [PMID:22152483|PMID:9822678]
experiment: EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:22152483]
experiment: EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (ubiquinone) activity [PMID:18028869]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:22152483]
experiment: EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]
note: Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication
codon start: 1
product: succinate dehydrogenase cytochrome b subunit SDH3
translation: MSAMMVKLGLNKSALLLKPSAFSRAAALSSSRRLLFNTARTNFLSTSPLKNVASEMNTKAAIAEEQILNKQRAKRPISPHLTIYQPQLTWYLSSLHRISLVLMGLGFYLFTILFGVSGLLGLGLTTEKVSNWYHQKFSKITEWSIKGSFAYLFAIHYGGAIRHLIWDTAKELTLKGVYRTGYALIGFTAVLGTYLLTL
SIO_010081: YKL141W
subclass of: SO_0000673
so part of: YKL141W
location: 179667..180263
location: region:179667-180263:1
so has part: feature:179667-180263:1:exon

NP_012781.1
type: Protein
SIO_000068: ncbiprotein

S000001624
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:179667-180263:1:exon

YKL140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKL5
gene: TGL1
locus tag: YKL140W
gene synonym: YKL5
so part of: sequence
location: <180779..>182425
location: region:180779-182425:1
so has part: feature:180779-182425:1:exon
subclass of: SO_0000010

853717
type: Gene
SIO_000068: ncbigene

position:180779:1
position: 180779
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:182425:1
position: 182425
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180779-182425:1:exon

YKL140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKL5
gene: TGL1
locus tag: YKL140W
gene synonym: YKL5
product: sterol esterase
transcript id: NM_001179706.1
SIO_010081: YKL140W
subclass of: SO_0000673
so part of: YKL140W
location: <180779..>182425
location: region:180779-182425:1
so has part: feature:180779-182425:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180779-182425:1:exon

YKL140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKL5
gene: TGL1
locus tag: YKL140W
gene synonym: YKL5
EC number: 3.1.1.13
experiment: EXISTENCE:direct assay:GO:0004771 sterol esterase activity [PMID:15713625]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:15713625|PMID:24868093|PMID:10515935]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]
experiment: EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15713625]
experiment: EXISTENCE:mutant phenotype:GO:0044255 cellular lipid metabolic process [PMID:10515935]
note: Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
codon start: 1
product: sterol esterase
translation: MYFPFLGRLSITDYIIVVLVYIESIISSVLKLIPQPMINLFEWLINFSTSSDDNTIEEKLRSAPTIHEMCAIFDISVEDHLVRTEDNYILTLHRIPPISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDVWMGNNRGNKYSTAHLNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGSAQMFAAFSLSEKLNRKVSHFIAIAPAMTPKGLHNRIVDTLAKSSPGFMYLFFGRKIVLPSAVIWQRTLHPTLFNLCIDIANKILFNWKSFNILPRQKIASYAKLYSTTSVKSIVHWFQILRSQKFQMFEESDNMLNSLTRPYQIANFPTRTNIKIPILLIYGGIDSLVDIDVMKKNLPFNSVFDVKVDNYEHLDLIWGKDADTLVIAKVLRFIEFFNPGNVSVKTNQLLPSASLVEELPSTTWKTTHPTHGLSYRTHSADRSPLSVQADEADEVHNADNSRFLRRVFSTSAIDEDNENEHQDDTEDQIHKEQQRRLSAYLESSKDLRQLDANSSTTALDALNKE
SIO_010081: YKL140W
subclass of: SO_0000673
so part of: YKL140W
location: 180779..182425
location: region:180779-182425:1
so has part: feature:180779-182425:1:exon

NP_012782.1
type: Protein
SIO_000068: ncbiprotein

S000001623
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180779-182425:1:exon

YKL139W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTK1
locus tag: YKL139W
so part of: sequence
location: <182958..>184544
location: region:182958-184544:1
so has part: feature:182958-184544:1:exon
subclass of: SO_0000010

853718
type: Gene
SIO_000068: ncbigene

position:182958:1
position: 182958
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184544:1
position: 184544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182958-184544:1:exon

YKL139W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTK1
locus tag: YKL139W
product: cyclin-dependent serine/threonine protein kinase CTK1
transcript id: NM_001179705.1
SIO_010081: YKL139W
subclass of: SO_0000673
so part of: YKL139W
location: <182958..>184544
location: region:182958-184544:1
so has part: feature:182958-184544:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:182958-184544:1:exon

YKL139W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTK1
locus tag: YKL139W
EC number: 2.7.11.23
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:7565723]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9110987]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]
experiment: EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]
experiment: EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]
experiment: EXISTENCE:genetic interaction:GO:0031124 mRNA 3'-end processing [PMID:12504017]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:25416238]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12504017]
experiment: EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:17545469]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]
note: Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
codon start: 1
product: cyclin-dependent serine/threonine protein kinase CTK1
translation: MSYNNGNTYSKSYSRNNKRPLFGKRSPNPQSLARPPPPKRIRTDSGYQSNMDNISSHRVNSNDQPGHTKSRGNNNLSRYNDTSFQTSSRYQGSRYNNNNTSYENRPKSIKRDETKAEFLSHLPKGPKSVEKSRYNNSSNTSNDIKNGYHASKYYNHKGQEGRSVIAKKVPVSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPEPLVLDGLVSCHEYEVKLARKQKRPNILSTNTNNKGNGNSNNNNNNNNDDDDK
SIO_010081: YKL139W
subclass of: SO_0000673
so part of: YKL139W
location: 182958..184544
location: region:182958-184544:1
so has part: feature:182958-184544:1:exon

NP_012783.1
type: Protein
SIO_000068: ncbiprotein

S000001622
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:182958-184544:1:exon

YKL138C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HSK3
locus tag: YKL138C-A
so part of: sequence
location: complement(<184803..>185012)
location: region:184803-185012:-1
so has part: feature:184803-185012:-1:exon
subclass of: SO_0000010

853719
type: Gene
SIO_000068: ncbigene

position:184803:-1
position: 184803
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185012:-1
position: 185012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184803-185012:-1:exon

YKL138C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HSK3
locus tag: YKL138C-A
product: Hsk3p
transcript id: NM_001184513.1
SIO_010081: YKL138C-A
subclass of: SO_0000673
so part of: YKL138C-A
location: complement(<184803..>185012)
location: region:184803-185012:-1
so has part: feature:184803-185012:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184803-185012:-1:exon

YKL138C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HSK3
locus tag: YKL138C-A
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
codon start: 1
product: Hsk3p
translation: MNANKQRQYNQLAHELRELQTNLQETTKQLDIMSKQCNENLVGQLGKVHGSWLIGSYIYYMEQMLGKTQ
SIO_010081: YKL138C-A
subclass of: SO_0000673
so part of: YKL138C-A
location: complement(184803..185012)
location: region:184803-185012:-1
so has part: feature:184803-185012:-1:exon

NP_690844.1
type: Protein
SIO_000068: ncbiprotein

S000028421
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184803-185012:-1:exon

YKL138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL60
gene: MRPL31
locus tag: YKL138C
gene synonym: mL60
so part of: sequence
location: complement(<185286..>185681)
location: region:185286-185681:-1
so has part: feature:185286-185681:-1:exon
subclass of: SO_0000010

853720
type: Gene
SIO_000068: ncbigene

position:185286:-1
position: 185286
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185681:-1
position: 185681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185286-185681:-1:exon

YKL138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL60
gene: MRPL31
locus tag: YKL138C
gene synonym: mL60
product: mitochondrial 54S ribosomal protein YmL31
transcript id: NM_001179704.1
SIO_010081: YKL138C
subclass of: SO_0000673
so part of: YKL138C
location: complement(<185286..>185681)
location: region:185286-185681:-1
so has part: feature:185286-185681:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185286-185681:-1:exon

YKL138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL60
gene: MRPL31
locus tag: YKL138C
gene synonym: mL60
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL31
translation: MFGPFKLTSPVAGGLLWKIPWRMSTHQKTRQRERLRNVDQVIKQLTLGLHVQRCQDKGLTYQEAMESKKKYKPRSKSLRLLNKPSVFPKENQMSSKDKYWTFDKKAVGYRKGIHKVPKWTKISIRKAPKFF
SIO_010081: YKL138C
subclass of: SO_0000673
so part of: YKL138C
location: complement(185286..185681)
location: region:185286-185681:-1
so has part: feature:185286-185681:-1:exon

NP_012784.1
type: Protein
SIO_000068: ncbiprotein

S000001621
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185286-185681:-1:exon

YKL137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CMC1
locus tag: YKL137W
so part of: sequence
location: <185957..>186292
location: region:185957-186292:1
so has part: feature:185957-186292:1:exon
subclass of: SO_0000010

853721
type: Gene
SIO_000068: ncbigene

position:185957:1
position: 185957
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186292:1
position: 186292
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185957-186292:1:exon

YKL137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CMC1
locus tag: YKL137W
product: Cmc1p
transcript id: NM_001179703.1
SIO_010081: YKL137W
subclass of: SO_0000673
so part of: YKL137W
location: <185957..>186292
location: region:185957-186292:1
so has part: feature:185957-186292:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:185957-186292:1:exon

YKL137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CMC1
locus tag: YKL137W
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:18443040]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19703468]
experiment: EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:23198688]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18443040|PMID:23198688]
note: Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
codon start: 1
product: Cmc1p
translation: MEQNKDPQMISKHSSRLPIWVLSPREEQQARKNLKTETYKKCANFVQAMADCAKANGMKVFPTCDKQRDEMKSCLLFYQTDEKYLDGERDKIVLEKINKLEKLCQKQSSTK
SIO_010081: YKL137W
subclass of: SO_0000673
so part of: YKL137W
location: 185957..186292
location: region:185957-186292:1
so has part: feature:185957-186292:1:exon

NP_012785.2
type: Protein
SIO_000068: ncbiprotein

S000001620
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185957-186292:1:exon

YKL135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APL2
locus tag: YKL135C
so part of: sequence
location: complement(<186460..>188640)
location: region:186460-188640:-1
so has part: feature:186460-188640:-1:exon
subclass of: SO_0000010

853723
type: Gene
SIO_000068: ncbigene

position:186460:-1
position: 186460
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:188640:-1
position: 188640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:186460-188640:-1:exon

YKL135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APL2
locus tag: YKL135C
product: Apl2p
transcript id: NM_001179701.1
SIO_010081: YKL135C
subclass of: SO_0000673
so part of: YKL135C
location: complement(<186460..>188640)
location: region:186460-188640:-1
so has part: feature:186460-188640:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:186460-188640:-1:exon

YKL135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APL2
locus tag: YKL135C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]
experiment: EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:10564262]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]
note: Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
codon start: 1
product: Apl2p
translation: MPPLDKRIKKFLKDSIRIAPKISGKGELSELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNYAETHPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTAVICVAKLFQLNKDLCVELGVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVSQFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDRVTAHLQHVNPAVVLATIKVIVRNLPQIEYSSNSLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVKLEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQLGIKYAQESFVSKVLDILLELLERQDTIKDDCCISLCDLLRHCPGNDKMAKQVCAVFNTWSNPEVLLQSDIAKCNYVWLLGQHPNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRLHATLTGSMLQSVLELATQQTHELDVRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGTISSIYFKPDSNRRKGKKYVQNIVKGKHIEELESMAKNEISSKANDDVLLDFDERDDVTNTNAGMLNTLTTLGDLDDLFDFGPSEDATQINTNDTKAVQGLKELKLGGDSNGISSGGKNNPDVSGGNIVSQDLLDLF
SIO_010081: YKL135C
subclass of: SO_0000673
so part of: YKL135C
location: complement(186460..188640)
location: region:186460-188640:-1
so has part: feature:186460-188640:-1:exon

NP_012787.1
type: Protein
SIO_000068: ncbiprotein

S000001618
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:186460-188640:-1:exon

YKL134C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OCT1
locus tag: YKL134C
so part of: sequence
location: complement(<189124..>191442)
location: region:189124-191442:-1
so has part: feature:189124-191442:-1:exon
subclass of: SO_0000010

853724
type: Gene
SIO_000068: ncbigene

position:189124:-1
position: 189124
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:191442:-1
position: 191442
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:189124-191442:-1:exon

YKL134C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OCT1
locus tag: YKL134C
product: metalloendopeptidase
transcript id: NM_001179700.2
SIO_010081: YKL134C
subclass of: SO_0000673
so part of: YKL134C
location: complement(<189124..>191442)
location: region:189124-191442:-1
so has part: feature:189124-191442:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:189124-191442:-1:exon

YKL134C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OCT1
locus tag: YKL134C
EC number: 3.4.24.59
experiment: EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:8831696]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8035833]
experiment: EXISTENCE:genetic interaction:GO:0006879 cellular iron ion homeostasis [PMID:10332043]
experiment: EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:8831696]
experiment: EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:8035833]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:10332043]
experiment: EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:21525245]
note: Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
codon start: 1
product: metalloendopeptidase
translation: MLRTIILKAGSNASIPSPSRQNKLLRFFATAGAVSRTSPGSIKKIFDDNSYWRNINGQDANNSKISQYLFKKNKTGLFKNPYLTSPDGLRKFSQVSLQQAQELLDKMRNDFSESGKLTYIMNLDRLSDTLCRVIDLCEFIRSTHPDDAFVRAAQDCHEQMFEFMNVLNTDVSLCNILKSVLNNPEVSSKLSAEELKVGKILLDDFEKSGIYMNPDVREKFIQLSQEISLVGQEFINHTDYPGSNSVKIPCKDLDNSKVSTFLLKQLNKDVKGQNYKVPTFGYAAYALLKSCENEMVRKKLWTALHSCSDKQVKRLSHLIKLRAILANLMHKTSYAEYQLEGKMAKNPKDVQDFILTLMNNTIEKTANELKFIAELKAKDLKKPLTTNTDEILKLVRPWDRDYYTGKYFQLNPSNSPNAKEISYYFTLGNVIQGLSDLFQQIYGIRLEPAITDEGETWSPDVRRLNVISEEEGIIGIIYCDLFERNGKTSNPAHFTVCCSRQIYPSETDFSTIQVGENPDGTYFQLPVISLVCNFSPILIASKKSLCFLQLSEVETLFHEMGHAMHSMLGRTHMQNISGTRCATDFVELPSILMEHFAKDIRILTKIGKHYGTGETIQADMLQRFMKSTNFLQNCETYSQAKMAMLDQSFHDEKIISDIDNFDVVENYQALERRLKVLVDDQSNWCGRFGHLFGYGATYYSYLFDRTIASKIWYALFEDDPYSRKNGDKFKKHLLKWGGLKDPWKCIADVLECPMLEKGGSDAMEFIAQSHKS
SIO_010081: YKL134C
subclass of: SO_0000673
so part of: YKL134C
location: complement(189124..191442)
location: region:189124-191442:-1
so has part: feature:189124-191442:-1:exon

NP_012788.2
type: Protein
SIO_000068: ncbiprotein

S000001617
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:189124-191442:-1:exon

YKL133C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCI50
locus tag: YKL133C
so part of: sequence
location: complement(<191679..>193070)
location: region:191679-193070:-1
so has part: feature:191679-193070:-1:exon
subclass of: SO_0000010

853725
type: Gene
SIO_000068: ncbigene

position:191679:-1
position: 191679
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:193070:-1
position: 193070
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:191679-193070:-1:exon

YKL133C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCI50
locus tag: YKL133C
product: Rci50p
transcript id: NM_001179699.2
SIO_010081: YKL133C
subclass of: SO_0000673
so part of: YKL133C
location: complement(<191679..>193070)
location: region:191679-193070:-1
so has part: feature:191679-193070:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:191679-193070:-1:exon

YKL133C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCI50
locus tag: YKL133C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
note: Mitochondrial hypothetical protein; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication
codon start: 1
product: Rci50p
translation: MWKYLHRSVKNEGTVERLTNLNLFTNHRFKFYSTLKEQSFWRIPFKRRSKLQKWVLSTGIVSFIAFNIWWVYWPHHTFPKPVAKILRKGLHSEIKKEGANYQKSLEYYLEALEECKAENVDLLSDEYTGIEIKIGEMYEKLHMYNDATALYGDMLKKFYNELSKTTDKSTKRKFFLLKRDLQILVRFNEINKDSETNATLLIMHLLLAQREFLENSPEFKNVLSKSELLNNQQLDWKNFKGLPFIGKSKPDYQMHLNSKRKQELKIKEPESEQCVFMKELLTARDLYTRYCLNRSNLSGALNSKITTLEWMLLADSPLDDILLAQAELGSIFYLNSEKFEGSLYAIDNEPYKKSEPLELIRSRLQENQNSCLQYSADCYKSIISFANENQYPKVAMESEMDQRILKALSLAHYGIGVINLHKGRLRASKKELKKAIRISEMIRFNELIEEAQRELKKVDGTPI
SIO_010081: YKL133C
subclass of: SO_0000673
so part of: YKL133C
location: complement(191679..193070)
location: region:191679-193070:-1
so has part: feature:191679-193070:-1:exon

NP_012789.2
type: Protein
SIO_000068: ncbiprotein

S000001616
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:191679-193070:-1:exon

YKL132C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMA1
locus tag: YKL132C
so part of: sequence
location: complement(<193574..>194866)
location: region:193574-194866:-1
so has part: feature:193574-194866:-1:exon
subclass of: SO_0000010

853727
type: Gene
SIO_000068: ncbigene

position:193574:-1
position: 193574
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194866:-1
position: 194866
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:193574-194866:-1:exon

YKL132C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMA1
locus tag: YKL132C
product: putative tetrahydrofolate synthase
transcript id: NM_001179698.1
SIO_010081: YKL132C
subclass of: SO_0000673
so part of: YKL132C
location: complement(<193574..>194866)
location: region:193574-194866:-1
so has part: feature:193574-194866:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:193574-194866:-1:exon

YKL132C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMA1
locus tag: YKL132C
EC number: 6.3.2.17
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication
codon start: 1
product: putative tetrahydrofolate synthase
translation: MDDISGRQTLPRINRLLEHVGNPQDSLSILHIAGTNGKETVSKFLTSILQHPGQQRQRVLIGRYTTSSLLNAKEEDISINNEAISLIEYSRIEKELIEADSSLKLQCNNLELLTSVALVYFAKKNCQWCIIETGLAGKQDPGSIIAGQSRVCCAITNVGISDEAFLCKFLSQITESSTNKAIFLLDGSNDEFVRNTITKRCHDVGCPLEITDPSLRDYNVHTDTWGTLEVRLPYSEEEYQIFNLRVAIAVLDFLSKEKKVCISKDQLSQGLISVDWPRSLHRLDYCYESTSGKKIALLLDNANNAKAARNLACHLRTTYGDTPLTFVIAITTGKKVSPLLDPLIRPQDYVIVTRFGSVVGMPWIQSLEPVNLLAFIKNRYTRNVNMQPDLQSVWTFLETSGLKTIVPVIVCGSLYICKELLRLHNCHLPV
SIO_010081: YKL132C
subclass of: SO_0000673
so part of: YKL132C
location: complement(193574..194866)
location: region:193574-194866:-1
so has part: feature:193574-194866:-1:exon

NP_012790.1
type: Protein
SIO_000068: ncbiprotein

S000001615
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:193574-194866:-1:exon

YKL130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHE2
locus tag: YKL130C
so part of: sequence
location: complement(<195288..>196028)
location: region:195288-196028:-1
so has part: feature:195288-196028:-1:exon
subclass of: SO_0000010

853728
type: Gene
SIO_000068: ncbigene

position:195288:-1
position: 195288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196028:-1
position: 196028
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:195288-196028:-1:exon

YKL130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHE2
locus tag: YKL130C
product: She2p
transcript id: NM_001179696.1
SIO_010081: YKL130C
subclass of: SO_0000673
so part of: YKL130C
location: complement(<195288..>196028)
location: region:195288-196028:-1
so has part: feature:195288-196028:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:195288-196028:-1:exon

YKL130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHE2
locus tag: YKL130C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11101531]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8625407]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16890529|PMID:24056370]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11032818]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:24056370]
experiment: EXISTENCE:direct assay:GO:0008298 intracellular mRNA localization [PMID:11032818|PMID:24056370]
experiment: EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:28092367]
experiment: EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:28092367]
note: RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER
codon start: 1
product: She2p
translation: MSKDKDIKVTPGTCELVEQILALLSRYLSSYIHVLNKFISHLRRVATLRFERTTLIKFVKKLRFYNDCVLSYNASEFINEGKNELDPEADSFDKVILPIASMFVKCVETFDLLNYYLTQSLQKEILSKTLNEDLTLTAESILAIDDTYNHFVKFSQWMIESLRIGSNLLDLEVVQFAIKCADEDGTNIGETDNIFLQEILPVNSEEEFQTLSAAWHSILDGKLSALDEEFDVVATKWHDKFGKLKN
SIO_010081: YKL130C
subclass of: SO_0000673
so part of: YKL130C
location: complement(195288..196028)
location: region:195288-196028:-1
so has part: feature:195288-196028:-1:exon

NP_012792.1
type: Protein
SIO_000068: ncbiprotein

S000001613
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:195288-196028:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1126; Autonomously Replicating Sequence
so part of: sequence
location: 196042..196287
location: region:196042-196287:1
so has part: feature:196042-196287:1:region

S000119036
type: SGD
SIO_000068: sgd

position:196042:1
position: 196042
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:196287:1
position: 196287
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196042-196287:1:region

YKL129C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MYO3
locus tag: YKL129C
so part of: sequence
location: complement(<196349..>200167)
location: region:196349-200167:-1
so has part: feature:196349-200167:-1:exon
subclass of: SO_0000010

853729
type: Gene
SIO_000068: ncbigene

position:196349:-1
position: 196349
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:200167:-1
position: 200167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196349-200167:-1:exon

YKL129C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MYO3
locus tag: YKL129C
product: myosin 3
transcript id: NM_001179695.2
SIO_010081: YKL129C
subclass of: SO_0000673
so part of: YKL129C
location: complement(<196349..>200167)
location: region:196349-200167:-1
so has part: feature:196349-200167:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196349-200167:-1:exon

YKL129C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MYO3
locus tag: YKL129C
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:11604421]
experiment: EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18177206]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
note: One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication
codon start: 1
product: myosin 3
translation: MAVIKKGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLNLFNSNPYFELRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRPPTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRDYGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKVFILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKSNKKPKNPGGLSGKPIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAATAAQAAYNPKPDKTVPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSAKQNQVSMPPSKGVEKNKEPLKETTATATANIPIPPPPPPMGQPKDPKFEAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTRNTVPVAATGAVNDVTNQKSSQIDNTISSAQEGVQFGSATVGPTSDNQSNPVGTFSDGLASALAARANKMRAESADDDDNDDGDDDDDW
SIO_010081: YKL129C
subclass of: SO_0000673
so part of: YKL129C
location: complement(196349..200167)
location: region:196349-200167:-1
so has part: feature:196349-200167:-1:exon

NP_012793.2
type: Protein
SIO_000068: ncbiprotein

S000001612
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196349-200167:-1:exon

YKL128C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMU1
locus tag: YKL128C
so part of: sequence
location: complement(<200884..>201771)
location: region:200884-201771:-1
so has part: feature:200884-201771:-1:exon
subclass of: SO_0000010

853730
type: Gene
SIO_000068: ncbigene

position:200884:-1
position: 200884
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201771:-1
position: 201771
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:200884-201771:-1:exon

YKL128C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMU1
locus tag: YKL128C
product: putative phosphomutase
transcript id: NM_001179694.1
SIO_010081: YKL128C
subclass of: SO_0000673
so part of: YKL128C
location: complement(<200884..>201771)
location: region:200884-201771:-1
so has part: feature:200884-201771:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:200884-201771:-1:exon

YKL128C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMU1
locus tag: YKL128C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; localizes to cytosol an peroxisomes
codon start: 1
product: putative phosphomutase
translation: MSLRAVPGYFAAYPSEGFQGLDSTKYDHLELINHKNWKELYHAIPRNTKNRHYKLLILARHGQGYHNAAILRYGMEKWDAYWSLLSGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKQLGMLPHVFFSSPMRRCLETFIESWTPVLAETQELPAGTKISTRIIEGLRETLGSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIYNLDTGKVVAVVVEVPVNTADRGRL
SIO_010081: YKL128C
subclass of: SO_0000673
so part of: YKL128C
location: complement(200884..201771)
location: region:200884-201771:-1
so has part: feature:200884-201771:-1:exon

NP_012794.1
type: Protein
SIO_000068: ncbiprotein

S000001611
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:200884-201771:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(202644..202983)
location: region:202644-202983:-1
so has part: feature:202644-202983:-1:region

S000007054
type: SGD
SIO_000068: sgd

position:202644:-1
position: 202644
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:202983:-1
position: 202983
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202644-202983:-1:region

YNCK0007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0007W
so part of: sequence
location: 202999..203071
location: region:202999-203071:1
so has part: feature:202999-203071:1:exon
subclass of: SO_0000663

853731
type: Gene
SIO_000068: ncbigene

position:202999:1
position: 202999
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:203071:1
position: 203071
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202999-203071:1:exon

YNCK0007W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0007W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCK0007W
subclass of: SO_0000673
so part of: YNCK0007W
location: 202999..203071
location: region:202999-203071:1
so has part: feature:202999-203071:1:exon

S000006626
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202999-203071:1:exon

YKL127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PGM1
locus tag: YKL127W
so part of: sequence
location: <203541..>205253
location: region:203541-205253:1
so has part: feature:203541-205253:1:exon
subclass of: SO_0000010

853732
type: Gene
SIO_000068: ncbigene

position:203541:1
position: 203541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:205253:1
position: 205253
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:203541-205253:1:exon

YKL127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PGM1
locus tag: YKL127W
product: phosphoglucomutase PGM1
transcript id: NM_001179693.1
SIO_010081: YKL127W
subclass of: SO_0000673
so part of: YKL127W
location: <203541..>205253
location: region:203541-205253:1
so has part: feature:203541-205253:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:203541-205253:1:exon

YKL127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PGM1
locus tag: YKL127W
EC number: 5.4.2.2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8385141]
experiment: EXISTENCE:genetic interaction:GO:0004614 phosphoglucomutase activity [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0006011 UDP-glucose metabolic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0019255 glucose 1-phosphate metabolic process [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:8119301]
experiment: EXISTENCE:genetic interaction:GO:0051156 glucose 6-phosphate metabolic process [PMID:8119301]
note: Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication
codon start: 1
product: phosphoglucomutase PGM1
translation: MSLLIDSVPTVAYKDQKPGTSGLRKKTKVFMDEPHYTENFIQATMQSIPNGSEGTTLVVGGDGRFYNDVIMNKIAAVGAANGVRKLVIGQGGLLSTPAASHIIRTYEEKCTGGGIILTASHNPGGPENDLGIKYNLPNGGPAPESVTNAIWEASKKLTHYKIIKNFPKLNLNKLGKNQKYGPLLVDIIDPAKAYVQFLKEIFDFDLIKSFLAKQRKDKGWKLLFDSLNGITGPYGKAIFVDEFGLPAEEVLQNWHPLPDFGGLHPDPNLTYARTLVDRVDREKIAFGAASDGDGDRNMIYGYGPAFVSPGDSVAIIAEYAPEIPYFAKQGIYGLARSFPTSSAIDRVAAKKGLRCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHIREKDGLWAIIAWLNILAIYHRRNPEKEASIKTIQDEFWNEYGRTFFTRYDYEHIECEQAEKVVALLSEFVSRPNVCGSHFPADESLTVIDCGDFSYRDLDGSISENQGLFVKFSNGTKFVLRLSGTGSSGATIRLYVEKYTDKKENYGQTADVFLKPVINSIVKFLRFKEILGTDEPTVRT
SIO_010081: YKL127W
subclass of: SO_0000673
so part of: YKL127W
location: 203541..205253
location: region:203541-205253:1
so has part: feature:203541-205253:1:exon

NP_012795.1
type: Protein
SIO_000068: ncbiprotein

S000001610
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:203541-205253:1:exon

YKL126W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLI2
gene: YPK1
locus tag: YKL126W
gene synonym: SLI2
so part of: sequence
location: <205707..>207749
location: region:205707-207749:1
so has part: feature:205707-207749:1:exon
subclass of: SO_0000010

853733
type: Gene
SIO_000068: ncbigene

position:205707:1
position: 205707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:207749:1
position: 207749
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205707-207749:1:exon

YKL126W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLI2
gene: YPK1
locus tag: YKL126W
gene synonym: SLI2
product: serine/threonine protein kinase YPK1
transcript id: NM_001179692.1
SIO_010081: YKL126W
subclass of: SO_0000673
so part of: YKL126W
location: <205707..>207749
location: region:205707-207749:1
so has part: feature:205707-207749:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:205707-207749:1:exon

YKL126W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLI2
gene: YPK1
locus tag: YKL126W
gene synonym: SLI2
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:19966303|PMID:22080611|PMID:29352143]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10825204|PMID:12221112]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10825204]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10825204]
experiment: EXISTENCE:genetic interaction:GO:0006650 glycerophospholipid metabolic process [PMID:25258318]
experiment: EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]
experiment: EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:18296441]
experiment: EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:25378585]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10825204|PMID:26274562]
experiment: EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:25258318]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]
experiment: EXISTENCE:mutant phenotype:GO:0061093 negative regulation of phospholipid translocation [PMID:19966303]
experiment: EXISTENCE:mutant phenotype:GO:0071311 cellular response to acetate [PMID:27671892]
experiment: EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:22080611]
note: S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant
codon start: 1
product: serine/threonine protein kinase YPK1
translation: MYSWKSKFKFGKSKEEKEAKHSGFFHSSKKEEQQNNQATAGEHDASITRSSLDRKGTINPSNSSVVPVRVSYDASSSTSTVRDSNGGNSENTNSSQNLDETANIGSTGTPNDATSSSGMMTIKVYNGDDFILPFPITSSEQILNKLLASGVPPPHKEISKEVDALIAQLSRVQIKNQGPADEDLISSESAAKFIPSTIMLPGSSTLNPLLYFTIEFDNTVATIEAEYGTIAKPGFNKISTFDVTRKLPYLKIDVFARIPSILLPSKTWQQEMGLQDEKLQTIFDKINSNQDIHLDSFHLPINLSFDSAASIRLYNHHWITLDNGLGKINISIDYKPSRNKPLSIDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFIVPLKFSFQSPEKLYFVLAFINGGELFYHLQKEGRFDLSRARFYTAELLCALDNLHKLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLGYTKAVDWWTLGVLLYEMLTGLPPYYDEDVPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYNGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDEEFTREKPIDSVVDEYLSESVQKQFGGWTYVGNEQLGSSMVQGRSIR
SIO_010081: YKL126W
subclass of: SO_0000673
so part of: YKL126W
location: 205707..207749
location: region:205707-207749:1
so has part: feature:205707-207749:1:exon

NP_012796.1
type: Protein
SIO_000068: ncbiprotein

S000001609
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205707-207749:1:exon

YKL125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRN3
locus tag: YKL125W
so part of: sequence
location: <208247..>210130
location: region:208247-210130:1
so has part: feature:208247-210130:1:exon
subclass of: SO_0000010

853734
type: Gene
SIO_000068: ncbigene

position:208247:1
position: 208247
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210130:1
position: 210130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:208247-210130:1:exon

YKL125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRN3
locus tag: YKL125W
product: rDNA-binding RNA polymerase I transcriptional factor
transcript id: NM_001179691.1
SIO_010081: YKL125W
subclass of: SO_0000673
so part of: YKL125W
location: <208247..>210130
location: region:208247-210130:1
so has part: feature:208247-210130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:208247-210130:1:exon

YKL125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRN3
locus tag: YKL125W
experiment: EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:23393135]
experiment: EXISTENCE:direct assay:GO:0001042 RNA polymerase I core binding [PMID:11032814]
experiment: EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]
experiment: EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19416370]
experiment: EXISTENCE:genetic interaction:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]
experiment: EXISTENCE:mutant phenotype:GO:0006361 transcription initiation at RNA polymerase I promoter [PMID:8670901]
experiment: EXISTENCE:physical interaction:GO:0001042 RNA polymerase I core binding [PMID:11032814]
experiment: EXISTENCE:physical interaction:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]
experiment: EXISTENCE:physical interaction:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]
note: Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
codon start: 1
product: rDNA-binding RNA polymerase I transcriptional factor
translation: MMAFENTSKRPPQDFVAPIDQKKRKVQFSDSTGLVTLQPEEIKDEVFSAAMYSRFVKSALDDLDKNDSTQIGIIANQVALPSKNPERINDKNLNILLDILSSNINRIESSRGTFLIQSIINFEKWWELPPHTLSKYIYFIKILCSSIPKWWQDVSMILVSCFILPIKQTVCHHDMLKYFLRMIPSSMGFIDTYLAKFFPNKNDTRRKLVNYTSNLLKLRGYCSELGFQIWSLLIEKIISIDVELQNELDELDDDVDDDDLEEVDLEDDDDLDDDSGDDDDENCGNSNEELRSGAADGSQSDSEDMDIIEGMDGTEEYNVELTQGIKELSTKLDSILTLVSTHVEEQVTPESLESGEGVGVFNTLTTLFKTHVLPTYYTRSIQYIMFHVSQQQLELMDSFLVTLIDISFAVNEAAEKKIKSLQYLGSYIARAKKLSRTQIIFVASYLTSWLNRYVIEREEEVDQRGGMERFKHFYAAFQALCYIFCFRHNIFRDTDGNWECELDKFFQRMVISKFNPLKFCNENVMLMFARIAQQESVAYCFSIIENNNNERLRGIIGKADSDKKENSAQANTTSSSWSLATRQQFIDLQSYFPYDPLFLKNYKILMKEYYIEWSEASGEYESDGSDD
SIO_010081: YKL125W
subclass of: SO_0000673
so part of: YKL125W
location: 208247..210130
location: region:208247-210130:1
so has part: feature:208247-210130:1:exon

NP_012797.1
type: Protein
SIO_000068: ncbiprotein

S000001608
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:208247-210130:1:exon

YKL124W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MLF4
gene: SSH4
locus tag: YKL124W
gene synonym: MLF4
so part of: sequence
location: <210593..>212332
location: region:210593-212332:1
so has part: feature:210593-212332:1:exon
subclass of: SO_0000010

853735
type: Gene
SIO_000068: ncbigene

position:210593:1
position: 210593
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212332:1
position: 212332
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210593-212332:1:exon

YKL124W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MLF4
gene: SSH4
locus tag: YKL124W
gene synonym: MLF4
product: Ssh4p
transcript id: NM_001179690.1
SIO_010081: YKL124W
subclass of: SO_0000673
so part of: YKL124W
location: <210593..>212332
location: region:210593-212332:1
so has part: feature:210593-212332:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210593-212332:1:exon

YKL124W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MLF4
gene: SSH4
locus tag: YKL124W
gene synonym: MLF4
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17287526]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17287526]
experiment: EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:30361468|PMID:18367543]
experiment: EXISTENCE:mutant phenotype:GO:1990756 ubiquitin ligase-substrate adaptor activity [PMID:30361468]
note: Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
codon start: 1
product: Ssh4p
translation: MYVTFNEALDSSFGNLESPNHDFKVGDPNMVPTPPMDSDSAAISLAFLISLSITFAILMLILVVIAAYVTFCGDDESEYDEENALGTRTSGTLHSLFGKKHSGILLDSSFASPGGFDDEIVLQERELEELPKMSAYEVELYIRAKEFQMMSPPMVKDFGTYLDSDDQQFIKDRGIQSYFLLPSINDNIDEYGNFLPSFIVQDKLDIQFSKFNKSSSTVMNYPLPHNRKDAVYFEVKIFRHIQKSNSIFSIGLTTVPYPYFRVPGMAKYSIAYESTGKLRINNPFTASTLLPKLEEGDTVGFGYRYKTGTIFITHNGKKLMDVTQNIGIDLFIGIGAFNAAYTRTYTRDGLLEDPDNVSFREALSEGKDIEVAKDLQRVHDPHDESDEMTSDEVELHVNLGQVGFVFIEANVKKYAFGSVYGQIGIPPAYNGTEIKKDTILQKGEELPPRYADTDNFFGSMKVKEGSSSRITAQTSKPLWSVGTYERISSNFDRENNVYHDSLETDDNNTDNNVNNNDENAGCNENSPLLEDDGNKRPENSNTPREVSDGAINKNPRNKSTKKRQRNRGKSSKKKNRSRK
SIO_010081: YKL124W
subclass of: SO_0000673
so part of: YKL124W
location: 210593..212332
location: region:210593-212332:1
so has part: feature:210593-212332:1:exon

NP_012798.1
type: Protein
SIO_000068: ncbiprotein

S000001607
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210593-212332:1:exon

YKL122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRP21
locus tag: YKL122C
so part of: sequence
location: complement(<212495..>212998)
location: region:212495-212998:-1
so has part: feature:212495-212998:-1:exon
subclass of: SO_0000010

853737
type: Gene
SIO_000068: ncbigene

position:212495:-1
position: 212495
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212998:-1
position: 212998
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212495-212998:-1:exon

YKL122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRP21
locus tag: YKL122C
product: signal recognition particle subunit SRP21
transcript id: NM_001179688.1
SIO_010081: YKL122C
subclass of: SO_0000673
so part of: YKL122C
location: complement(<212495..>212998)
location: region:212495-212998:-1
so has part: feature:212495-212998:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212495-212998:-1:exon

YKL122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRP21
locus tag: YKL122C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]
experiment: EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]
note: Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
codon start: 1
product: signal recognition particle subunit SRP21
translation: MSVKPIDNYITNSVRLFEVNPSQTLFSISYKPPTQKTDTKVSFRTHNSHLSLNYKFTTNKSKDVSRLLSALGPRGVSITPGKIEKIAQSKKKNNKIKESSKKIKGKSIQDIVGLATLIVNTDVEKSDPAAKKTATEPKQKANAVQNNNGNSAASKKKKNKNKGKKKR
SIO_010081: YKL122C
subclass of: SO_0000673
so part of: YKL122C
location: complement(212495..212998)
location: region:212495-212998:-1
so has part: feature:212495-212998:-1:exon

NP_012800.1
type: Protein
SIO_000068: ncbiprotein

S000001605
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212495-212998:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1127; Autonomously Replicating Sequence
so part of: sequence
location: 213439..213743
location: region:213439-213743:1
so has part: feature:213439-213743:1:region

S000119037
type: SGD
SIO_000068: sgd

position:213439:1
position: 213439
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:213743:1
position: 213743
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:213439-213743:1:region

YKL121W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DGR2
locus tag: YKL121W
so part of: sequence
location: <214142..>216700
location: region:214142-216700:1
so has part: feature:214142-216700:1:exon
subclass of: SO_0000010

853738
type: Gene
SIO_000068: ncbigene

position:214142:1
position: 214142
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:216700:1
position: 216700
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214142-216700:1:exon

YKL121W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DGR2
locus tag: YKL121W
product: Dgr2p
transcript id: NM_001179687.1
SIO_010081: YKL121W
subclass of: SO_0000673
so part of: YKL121W
location: <214142..>216700
location: region:214142-216700:1
so has part: feature:214142-216700:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214142-216700:1:exon

YKL121W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DGR2
locus tag: YKL121W
note: hypothetical protein; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication
codon start: 1
product: Dgr2p
translation: MFKSKTSTLSYDETPNSNEGDRNATPVNPKEKSQTKHLNIPGDRSRHSSIADSKRSSSRYDGGYSADIIPAQLRFIDNIDYGTRLRKTLHRNSVVSNGYNKLSENDRWYFDLFDRKYFENYLEEPTYIKIFKKKEGLEQFDRMFLAQELKIPDVYKSTTYQGEPAVANSELFKNSICCCTFSHDGKYMVIGCKDGSLHLWKVINSPVKRSEMGRSEKSVSASRANSLKIQRHLASISSHNGSISSNDLKPSDQFEGPSKQLHLYAPVFYSDVFRVFMEHALDILDANWSKNGFLITASMDKTAKLWHPERKYSLKTFVHPDFVTSAIFFPNDDRFIITGCLDHRCRLWSILDNEVSYAFDCKDLITSLTLSPPGGEYTIIGTFNGYIYVLLTHGLKFVSSFHVSDKSTQGTTKNSFHPSSEYGKVQHGPRITGLQCFFSKVDKNLRLIVTTNDSKIQIFDLNEKKPLELFKGFQSGSSRHRGQFLMMKNEPVVFTGSDDHWFYTWKMQSFNLSAEMNCTAPHRKKRLSGSMSLKGLLRIVSNKSTNDECLTETSNQSSSHTFTNSSKNVLQTQTVGSQAIKNNHYISFHAHNSPVTCASIAPDVAIKNLSLSNDLIFELTSQYFKEMGQNYSESKETCDNKPNHPVTETGGFSSNLSNVVNNVGTILITTDSQGLIRVFRTDILPEIRKKIIEKFHEYNLFHLEAAGKINNHNNDSILENRMDERSSTEDNEFSTTPPSNTHNSRPSHDFCELHPNNSPVISGMPSRASAIFKNSIFNKSNGSFISLKSRSESTSSTVFGPHDIPRVSTTYPKLKCDVCNGSNFECASKNPIAGGDSGFTCADCGTILNNFR
SIO_010081: YKL121W
subclass of: SO_0000673
so part of: YKL121W
location: 214142..216700
location: region:214142-216700:1
so has part: feature:214142-216700:1:exon

NP_012801.1
type: Protein
SIO_000068: ncbiprotein

S000001604
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214142-216700:1:exon

YKL120W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OAC1
locus tag: YKL120W
so part of: sequence
location: <217344..>218318
location: region:217344-218318:1
so has part: feature:217344-218318:1:exon
subclass of: SO_0000010

853739
type: Gene
SIO_000068: ncbigene

position:217344:1
position: 217344
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218318:1
position: 218318
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217344-218318:1:exon

YKL120W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OAC1
locus tag: YKL120W
product: Oac1p
transcript id: NM_001179686.1
SIO_010081: YKL120W
subclass of: SO_0000673
so part of: YKL120W
location: <217344..>218318
location: region:217344-218318:1
so has part: feature:217344-218318:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217344-218318:1:exon

YKL120W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OAC1
locus tag: YKL120W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10428783]
experiment: EXISTENCE:direct assay:GO:0008272 sulfate transport [PMID:10428783]
experiment: EXISTENCE:direct assay:GO:0015116 sulfate transmembrane transporter activity [PMID:10428783]
experiment: EXISTENCE:direct assay:GO:0015131 oxaloacetate transmembrane transporter activity [PMID:10428783]
experiment: EXISTENCE:direct assay:GO:0015729 oxaloacetate transport [PMID:10428783]
experiment: EXISTENCE:direct assay:GO:0034658 isopropylmalate transmembrane transporter activity [PMID:18682385]
experiment: EXISTENCE:direct assay:GO:0034659 isopropylmalate transport [PMID:18682385]
experiment: EXISTENCE:direct assay:GO:1901239 malonate(1-) transmembrane transporter activity [PMID:10428783]
note: Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
codon start: 1
product: Oac1p
translation: MSSDNSKQDKQIEKTAAQKISKFGSFVAGGLAACIAVTVTNPIELIKIRMQLQGEMSASAAKVYKNPIQGMAVIFKNEGIKGLQKGLNAAYIYQIGLNGSRLGFYEPIRSSLNQLFFPDQEPHKVQSVGVNVFSGAASGIIGAVIGSPLFLVKTRLQSYSEFIKIGEQTHYTGVWNGLVTIFKTEGVKGLFRGIDAAILRTGAGSSVQLPIYNTAKNILVKNDLMKDGPALHLTASTISGLGVAVVMNPWDVILTRIYNQKGDLYKGPIDCLVKTVRIEGVTALYKGFAAQVFRIAPHTIMCLTFMEQTMKLVYSIESRVLGHN
SIO_010081: YKL120W
subclass of: SO_0000673
so part of: YKL120W
location: 217344..218318
location: region:217344-218318:1
so has part: feature:217344-218318:1:exon

NP_012802.1
type: Protein
SIO_000068: ncbiprotein

S000001603
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217344-218318:1:exon

YKL119C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLS10
alternative label: VMA12
gene: VPH2
locus tag: YKL119C
gene synonym: CLS10; VMA12
so part of: sequence
location: complement(<218570..>219217)
location: region:218570-219217:-1
so has part: feature:218570-219217:-1:exon
subclass of: SO_0000010

853741
type: Gene
SIO_000068: ncbigene

position:218570:-1
position: 218570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:219217:-1
position: 219217
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:218570-219217:-1:exon

YKL119C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLS10
alternative label: VMA12
gene: VPH2
locus tag: YKL119C
gene synonym: CLS10; VMA12
product: Vph2p
transcript id: NM_001179685.1
SIO_010081: YKL119C
subclass of: SO_0000673
so part of: YKL119C
location: complement(<218570..>219217)
location: region:218570-219217:-1
so has part: feature:218570-219217:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:218570-219217:-1:exon

YKL119C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLS10
alternative label: VMA12
gene: VPH2
locus tag: YKL119C
gene synonym: CLS10; VMA12
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9325326]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:1628805]
experiment: EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:9325326]
experiment: EXISTENCE:physical interaction:GO:1990871 Vma12-Vma22 assembly complex [PMID:9660861]
note: Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
codon start: 1
product: Vph2p
translation: MFEIKLNDRITEFLRKFKNSAKSNEGIDEDIDLFLKRHAIPMQSLLFYVKEYRKDSDLQCSIKELLKPLEFEFKPKAVRGLHYSEDFKKKLEFLKYQEQELEYQSMVKRSKSVFSLQEDDELTPSQINKQIKEQVTTVFNVLVSVISVVVAIWYWTGSSTNFPVHVRLLLCLFFGILVLVADVVVYNSYLKKLEEAKVKEKTKVEKKKVLSKITL
SIO_010081: YKL119C
subclass of: SO_0000673
so part of: YKL119C
location: complement(218570..219217)
location: region:218570-219217:-1
so has part: feature:218570-219217:-1:exon

NP_012803.1
type: Protein
SIO_000068: ncbiprotein

S000001602
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:218570-219217:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(219395..219723)
location: region:219395-219723:-1
so has part: feature:219395-219723:-1:region

S000007051
type: SGD
SIO_000068: sgd

position:219395:-1
position: 219395
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:219723:-1
position: 219723
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:219395-219723:-1:region

YNCK0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0008W
so part of: sequence
location: 219895..219967
location: region:219895-219967:1
so has part: feature:219895-219967:1:exon
subclass of: SO_0000663

853742
type: Gene
SIO_000068: ncbigene

position:219895:1
position: 219895
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:219967:1
position: 219967
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:219895-219967:1:exon

YNCK0008W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0008W
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCK0008W
subclass of: SO_0000673
so part of: YNCK0008W
location: 219895..219967
location: region:219895-219967:1
so has part: feature:219895-219967:1:exon

S000006515
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:219895-219967:1:exon

YKL117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CST18
gene: SBA1
locus tag: YKL117W
gene synonym: CST18
so part of: sequence
location: <220324..>220974
location: region:220324-220974:1
so has part: feature:220324-220974:1:exon
subclass of: SO_0000010

853743
type: Gene
SIO_000068: ncbigene

position:220324:1
position: 220324
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220974:1
position: 220974
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220324-220974:1:exon

YKL117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CST18
gene: SBA1
locus tag: YKL117W
gene synonym: CST18
product: Hsp90 cochaperone SBA1
transcript id: NM_001179683.1
SIO_010081: YKL117W
subclass of: SO_0000673
so part of: YKL117W
location: <220324..>220974
location: region:220324-220974:1
so has part: feature:220324-220974:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220324-220974:1:exon

YKL117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CST18
gene: SBA1
locus tag: YKL117W
gene synonym: CST18
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10207098]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10207098]
experiment: EXISTENCE:direct assay:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17389357]
experiment: EXISTENCE:direct assay:GO:0043392 negative regulation of DNA binding [PMID:23022381]
experiment: EXISTENCE:direct assay:GO:0051972 regulation of telomerase activity [PMID:17389357]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9632755]
experiment: EXISTENCE:mutant phenotype:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17389357]
experiment: EXISTENCE:mutant phenotype:GO:0051087 chaperone binding [PMID:9632755]
experiment: EXISTENCE:mutant phenotype:GO:0051972 regulation of telomerase activity [PMID:17389357]
experiment: EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:9632755]
experiment: EXISTENCE:physical interaction:GO:0051087 chaperone binding [PMID:9632755]
note: Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
codon start: 1
product: Hsp90 cochaperone SBA1
translation: MSDKVINPQVAWAQRSSTTDPERNYVLITVSIADCDAPELTIKPSYIELKAQSKPHVGDENVHHYQLHIDLYKEIIPEKTMHKVANGQHYFLKLYKKDLESEYWPRLTKEKVKYPYIKTDFDKWVDEDEQDEVEAEGNDAAQGMDFSQMMGGAGGAGGAGGMDFSQMMGGAGGAGSPDMAQLQQLLAQSGGNLDMGDFKENDEEDEEEEIEPEVKA
SIO_010081: YKL117W
subclass of: SO_0000673
so part of: YKL117W
location: 220324..220974
location: region:220324-220974:1
so has part: feature:220324-220974:1:exon

NP_012805.1
type: Protein
SIO_000068: ncbiprotein

S000001600
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220324-220974:1:exon

YKL116C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRR1
locus tag: YKL116C
so part of: sequence
location: complement(<221344..>222900)
location: region:221344-222900:-1
so has part: feature:221344-222900:-1:exon
subclass of: SO_0000010

853744
type: Gene
SIO_000068: ncbigene

position:221344:-1
position: 221344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222900:-1
position: 222900
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221344-222900:-1:exon

YKL116C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRR1
locus tag: YKL116C
product: serine/threonine protein kinase PRR1
transcript id: NM_001179682.1
SIO_010081: YKL116C
subclass of: SO_0000673
so part of: YKL116C
location: complement(<221344..>222900)
location: region:221344-222900:-1
so has part: feature:221344-222900:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221344-222900:-1:exon

YKL116C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRR1
locus tag: YKL116C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]
experiment: EXISTENCE:genetic interaction:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]
experiment: EXISTENCE:mutant phenotype:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]
note: Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor
codon start: 1
product: serine/threonine protein kinase PRR1
translation: MDEYSSIYSQPKTPRLKQEGFPDSIGDQHEKALIDENGEEDKKMASTEGTTGDSRSTPLTVSIPTFENVQALPTPMTYTPLSPGNLSMSPIDQSSLNIPKRRSHARLLDDMLSVTQPNQRVVSELIAPANLSPQRVVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLKSLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNGRLEAWLIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELADFGLCKKIENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNASARQRSRATSHRIARFDWRWYRLSDYKTNVGKQIVENTLTRKNQRWSINEIYESPFVKTIADTLSFS
SIO_010081: YKL116C
subclass of: SO_0000673
so part of: YKL116C
location: complement(221344..222900)
location: region:221344-222900:-1
so has part: feature:221344-222900:-1:exon

NP_012806.1
type: Protein
SIO_000068: ncbiprotein

S000001599
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221344-222900:-1:exon

YKL114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APN1
locus tag: YKL114C
so part of: sequence
location: complement(<223352..>224455)
location: region:223352-224455:-1
so has part: feature:223352-224455:-1:exon
subclass of: SO_0000010

853746
type: Gene
SIO_000068: ncbigene

position:223352:-1
position: 223352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:224455:-1
position: 224455
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:223352-224455:-1:exon

YKL114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APN1
locus tag: YKL114C
product: DNA-(apurinic or apyrimidinic site) lyase APN1
transcript id: NM_001179680.1
SIO_010081: YKL114C
subclass of: SO_0000673
so part of: YKL114C
location: complement(<223352..>224455)
location: region:223352-224455:-1
so has part: feature:223352-224455:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:223352-224455:-1:exon

YKL114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APN1
locus tag: YKL114C
experiment: EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:12767225]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7690756]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11238901]
experiment: EXISTENCE:direct assay:GO:0006284 base-excision repair [PMID:9295360]
experiment: EXISTENCE:direct assay:GO:0008081 phosphoric diester hydrolase activity [PMID:3056935]
experiment: EXISTENCE:direct assay:GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity [PMID:16024777]
experiment: EXISTENCE:direct assay:GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity [PMID:12397185]
experiment: EXISTENCE:mutant phenotype:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:1693433]
note: Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity
codon start: 1
product: DNA-(apurinic or apyrimidinic site) lyase APN1
translation: MPSTPSFVRSAVSKYKFGAHMSGAGGISNSVTNAFNTGCNSFAMFLKSPRKWVSPQYTQEEIDKFKKNCATYNYNPLTDVLPHGQYFINLANPDREKAEKSYESFMDDLNRCEQLGIGLYNLHPGSTLKGDHQLQLKQLASYLNKAIKETKFVKIVLENMAGTGNLVGSSLVDLKEVIGMIEDKSRIGVCIDTCHTFAAGYDISTTETFNNFWKEFNDVIGFKYLSAVHLNDSKAPLGANRDLHERLGQGYLGIDVFRMIAHSEYLQGIPIVLETPYENDEGYGNEIKLMEWLESKSESELLEDKEYKEKNDTLQKLGAKSRKEQLDKFEVKQKKRAGGTKRKKATAEPSDNDILSQMTKKRKTKKE
SIO_010081: YKL114C
subclass of: SO_0000673
so part of: YKL114C
location: complement(223352..224455)
location: region:223352-224455:-1
so has part: feature:223352-224455:-1:exon

NP_012808.1
type: Protein
SIO_000068: ncbiprotein

S000001597
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:223352-224455:-1:exon

YKL113C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ERC11
alternative label: FEN1
alternative label: RTH1
gene: RAD27
locus tag: YKL113C
gene synonym: ERC11; FEN1; RTH1
so part of: sequence
location: complement(<224727..>225875)
location: region:224727-225875:-1
so has part: feature:224727-225875:-1:exon
subclass of: SO_0000010

853747
type: Gene
SIO_000068: ncbigene

position:224727:-1
position: 224727
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225875:-1
position: 225875
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224727-225875:-1:exon

YKL113C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ERC11
alternative label: FEN1
alternative label: RTH1
gene: RAD27
locus tag: YKL113C
gene synonym: ERC11; FEN1; RTH1
product: multifunctional nuclease RAD27
transcript id: NM_001179679.1
SIO_010081: YKL113C
subclass of: SO_0000673
so part of: YKL113C
location: complement(<224727..>225875)
location: region:224727-225875:-1
so has part: feature:224727-225875:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224727-225875:-1:exon

YKL113C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ERC11
alternative label: FEN1
alternative label: RTH1
gene: RAD27
locus tag: YKL113C
gene synonym: ERC11; FEN1; RTH1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19699691|PMID:22932476|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19699691]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]
experiment: EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:9166764]
experiment: EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:11825897]
experiment: EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]
experiment: EXISTENCE:genetic interaction:GO:0006286 base-excision repair, base-free sugar-phosphate removal [PMID:9927726]
experiment: EXISTENCE:genetic interaction:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]
experiment: EXISTENCE:mutant phenotype:GO:0006286 base-excision repair, base-free sugar-phosphate removal [PMID:9927726]
experiment: EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:10025407]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]
note: 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: multifunctional nuclease RAD27
translation: MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTKRSSRRVETEKKLAEATTELEKMKQERRLVKVSKEHNEEAQKLLGLMGIPYIIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTPFLLRHLTFSEAKKEPIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYCESIRGVGPVTALKLIKTHGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNEINLKWSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFFQVVPKTKEQLAAAAKRAQENKKLNKNKNKVTKGRR
SIO_010081: YKL113C
subclass of: SO_0000673
so part of: YKL113C
location: complement(224727..225875)
location: region:224727-225875:-1
so has part: feature:224727-225875:-1:exon

NP_012809.1
type: Protein
SIO_000068: ncbiprotein

S000001596
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224727-225875:-1:exon

YKL112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BAF1
alternative label: EBF2
alternative label: OBF1
alternative label: REB2
alternative label: SBF1
gene: ABF1
locus tag: YKL112W
gene synonym: BAF1; EBF2; OBF1; REB2; SBF1
so part of: sequence
location: <226570..>228765
location: region:226570-228765:1
so has part: feature:226570-228765:1:exon
subclass of: SO_0000010

853748
type: Gene
SIO_000068: ncbigene

position:226570:1
position: 226570
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228765:1
position: 228765
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226570-228765:1:exon

YKL112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BAF1
alternative label: EBF2
alternative label: OBF1
alternative label: REB2
alternative label: SBF1
gene: ABF1
locus tag: YKL112W
gene synonym: BAF1; EBF2; OBF1; REB2; SBF1
product: DNA-binding protein ABF1
transcript id: NM_001179678.1
SIO_010081: YKL112W
subclass of: SO_0000673
so part of: YKL112W
location: <226570..>228765
location: region:226570-228765:1
so has part: feature:226570-228765:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:226570-228765:1:exon

YKL112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BAF1
alternative label: EBF2
alternative label: OBF1
alternative label: REB2
alternative label: SBF1
gene: ABF1
locus tag: YKL112W
gene synonym: BAF1; EBF2; OBF1; REB2; SBF1
experiment: EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:10601031]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7663308|PMID:27016735]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:7663308]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:3281162|PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15522095]
experiment: EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:11756546]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:10684934|PMID:11713306]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:3275867|PMID:7663308|PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0044374 sequence-specific DNA binding, bending [PMID:8206955]
experiment: EXISTENCE:direct assay:GO:0070911 global genome nucleotide-excision repair [PMID:15177043]
experiment: EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:10684934|PMID:11713306]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15192094]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:15522095]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16908533|PMID:8582634]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15192094]
experiment: EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:10601031]
note: DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair
codon start: 1
product: DNA-binding protein ABF1
translation: MDKLVVNYYEYKHPIINKDLAIGAHGGKKFPTLGAWYDVINEYEFQTRCPIILKNSHRNKHFTFACHLKNCPFKVLLSYAGNAASSETSSPSANNNTNPPGTPDHIHHHSNNMNNEDNDNNNGSNNKVSNDSKLDFVTDDLEYHLANTHPDDTNDKVESRSNEVNGNNDDDADANNIFKQQGVTIKNDTEDDSINKASIDRGLDDESGPTHGNDSGNHRHNEEDDVHTQMTKNYSDVVNDEDINVAIANAVANVDSQSNNKHDGKDDDATNNNDGQDNNTNNDHNNNSNINNNNVGSHGISSHSPSSIRDTSMNLDVFNSATDDIPGPFVVTKIEPYHSHPLEDNLSLGKFILTKIPKILQNDLKFDQILESSYNNSNHTVSKFKVSHYVEESGLLDILMQRYGLTAEDFEKRLLSQIARRITTYKARFVLKKKKMGEYNDLQPSSSSNNNNNNDGELSGTNLRSNSIDYAKHQEISSAGTSSNTTKNVNNNKNDSNDDNNGNNNNDASNLMESVLDKTSSHRYQPKKMPSVNKWSKPDQITHSDVSMVGLDESNDGGNENVHPTLAEVDAQEARETAQLAIDKINSYKRSIDDKNGDGHNNSSRNVVDENLINDMDSEDAHKSKRQHLSDITLEERNEDDKLPHEVAEQLRLLSSHLKEVENLHQNNDDDVDDVMVDVDVESQYNKNTTHHNNHHSQPHHDEEDVAGLIGKADDEEDLSDENIQPELRGQ
SIO_010081: YKL112W
subclass of: SO_0000673
so part of: YKL112W
location: 226570..228765
location: region:226570-228765:1
so has part: feature:226570-228765:1:exon

NP_012810.1
type: Protein
SIO_000068: ncbiprotein

S000001595
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:226570-228765:1:exon

YKL110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TOT4
gene: KTI12
locus tag: YKL110C
gene synonym: TOT4
so part of: sequence
location: complement(<228939..>229880)
location: region:228939-229880:-1
so has part: feature:228939-229880:-1:exon
subclass of: SO_0000010

853750
type: Gene
SIO_000068: ncbigene

position:228939:-1
position: 228939
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229880:-1
position: 229880
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228939-229880:-1:exon

YKL110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TOT4
gene: KTI12
locus tag: YKL110C
gene synonym: TOT4
product: Kti12p
transcript id: NM_001179676.1
SIO_010081: YKL110C
subclass of: SO_0000673
so part of: YKL110C
location: complement(<228939..>229880)
location: region:228939-229880:-1
so has part: feature:228939-229880:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228939-229880:-1:exon

YKL110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TOT4
gene: KTI12
locus tag: YKL110C
gene synonym: TOT4
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:15772087]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15772087]
experiment: EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]
note: Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
codon start: 1
product: Kti12p
translation: MPLVLFTGYPCSGKTTLAKHLVQLLQSKIDATPSLSKYSITYHSDESLGIKHSDYITSQDERKLRSEIISAVKRDLSKNKIVIVDSLNYIKGFRYQLHCEVKNLSTTFCVIQTLCPPETIFEWNKTSNPNPWEPELLNQLIQRYEEPNSSNRWDSPLFAILTPQDNITDYIDDICKVVFQTSKSAKNSGHNDPLSKGLQKPNSATVLKPASQSNFIQVLDIETSKIIKTIMNHIKSLTSIGGVSNGTRVIVSEGITDINDDGCFFVDLPIGNVVTLAQLQRLKRQFINFNKLRDIDQDRIGPLFADYLNKNLN
SIO_010081: YKL110C
subclass of: SO_0000673
so part of: YKL110C
location: complement(228939..229880)
location: region:228939-229880:-1
so has part: feature:228939-229880:-1:exon

NP_012812.1
type: Protein
SIO_000068: ncbiprotein

S000001593
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228939-229880:-1:exon

YKL109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HAP4
locus tag: YKL109W
so part of: sequence
location: <232227..>233891
location: region:232227-233891:1
so has part: feature:232227-233891:1:exon
subclass of: SO_0000010

853751
type: Gene
SIO_000068: ncbigene

position:232227:1
position: 232227
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233891:1
position: 233891
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232227-233891:1:exon

YKL109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HAP4
locus tag: YKL109W
product: transcription factor HAP4
transcript id: NM_001179675.1
SIO_010081: YKL109W
subclass of: SO_0000673
so part of: YKL109W
location: <232227..>233891
location: region:232227-233891:1
so has part: feature:232227-233891:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232227-233891:1:exon

YKL109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HAP4
locus tag: YKL109W
experiment: EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:2676721]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11423663]
experiment: EXISTENCE:mutant phenotype:GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter [PMID:2676721]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:2123465]
experiment: EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2676721]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11423663]
note: Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift
codon start: 1
product: transcription factor HAP4
translation: MTAKTFLLQASASRPRSNHFKNEHNNIPLAPVPIAPNTNHHNNSSLEFENDGSKKKKKSSLVVRTSKHWVLPPRPRPGRRSSSHNTLPANNTNNILNVGPNSRNSSNNNNNNNIISNRKQASKEKRKIPRHIQTIDEKLINDSNYLAFLKFDDLENEKFHSSASSISSPSYSSPSFSSYRNRKKSEFMDDESCTDVETIAAHNSLLTKNHHIDSSSNVHAPPTKKSKLNDFDLLSLSSTSSSATPVPQLTKDLNMNLNFHKIPHKASFPDSPADFSPADSVSLIRNHSLPTNLQVKDKIEDLNEIKFFNDFEKLEFFNKYAKVNTNNDVNENNDLWNSYLQSMDDTTGKNSGNYQQVDNDDNMSLLNLPILEETVSSGQDDKVEPDEEDIWNYLPSSSSQQEDSSRALKKNTNSEKANIQAKNDETYLFLQDQDESADSHHHDELGSEITLADNKFSYLPPTLEELMEEQDCNNGRSFKNFMFSNDTGIDGSAGTDDDYTKVLKSKKISTSKSNANLYDLNDNNNDATATNELDQSSFIDDLDEDVDFLKVQVF
SIO_010081: YKL109W
subclass of: SO_0000673
so part of: YKL109W
location: 232227..233891
location: region:232227-233891:1
so has part: feature:232227-233891:1:exon

NP_012813.1
type: Protein
SIO_000068: ncbiprotein

S000001592
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232227-233891:1:exon

YKL108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DRC1
gene: SLD2
locus tag: YKL108W
gene synonym: DRC1
so part of: sequence
location: <234426..>235787
location: region:234426-235787:1
so has part: feature:234426-235787:1:exon
subclass of: SO_0000010

853752
type: Gene
SIO_000068: ncbigene

position:234426:1
position: 234426
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235787:1
position: 235787
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234426-235787:1:exon

YKL108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DRC1
gene: SLD2
locus tag: YKL108W
gene synonym: DRC1
product: Sld2p
transcript id: NM_001179674.1
SIO_010081: YKL108W
subclass of: SO_0000673
so part of: YKL108W
location: <234426..>235787
location: region:234426-235787:1
so has part: feature:234426-235787:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234426-235787:1:exon

YKL108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DRC1
gene: SLD2
locus tag: YKL108W
gene synonym: DRC1
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:21109535]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21109535]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:20231317]
experiment: EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:17167415|PMID:17167417]
experiment: EXISTENCE:genetic interaction:GO:0031261 DNA replication preinitiation complex [PMID:20231317]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0003688 DNA replication origin binding [PMID:21109535]
experiment: EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:21109535]
experiment: EXISTENCE:mutant phenotype:GO:0031333 negative regulation of protein-containing complex assembly [PMID:24307213]
experiment: EXISTENCE:mutant phenotype:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:10097122]
experiment: EXISTENCE:mutant phenotype:GO:0071163 DNA replication preinitiation complex assembly [PMID:20231317]
note: Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Sld2p
translation: MYSFELDKLKIELKTWEHDFIDKNKREPTRDDIKSLRTVRQMYKQYSTLKKKQSLQRQKVDTQESVELPAHKKDHDEVVEIGPTPQVYGKAISIFDMNLSPIKPIYMTFTNNIDVNNDNSKTISNESSPRKTILLKSSPADRTLVAEPISSVKRQLNFQMLNASSTRTPTSSPCKNRNGKLVEIKKCSPTINPPLESGKPSGYYGPNSPLKLDEENIHLNISLNSSTKRRLQIAYPSLQKTPSKDQADISTSFSPSPLIRRPLTKSLIELAREHTEIVKEFGVLQEEDIEEEEEGEEGENGYDEKNHEDDFGLEDELIRPKVVKDIFQEDDDNDDSQAREDTFIRKRPKRRKVIRRLRDNDPETETAGFERDVHKELVKLKRRKVAEFLGSTSQISDTEFEHDPEASSGVVSSEQKPTAKRKGRKKYNLVSNNFRRLKLPKKNRFSNGRWGRR
SIO_010081: YKL108W
subclass of: SO_0000673
so part of: YKL108W
location: 234426..235787
location: region:234426-235787:1
so has part: feature:234426-235787:1:exon

NP_012814.1
type: Protein
SIO_000068: ncbiprotein

S000001591
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234426-235787:1:exon

YKL107W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL107W
so part of: sequence
location: <236141..>237070
location: region:236141-237070:1
so has part: feature:236141-237070:1:exon
subclass of: SO_0000010

853753
type: Gene
SIO_000068: ncbigene

position:236141:1
position: 236141
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237070:1
position: 237070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:236141-237070:1:exon

YKL107W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL107W
product: putative short-chain dehydrogenase/reductase
transcript id: NM_001179673.1
SIO_010081: YKL107W
subclass of: SO_0000673
so part of: YKL107W
location: <236141..>237070
location: region:236141-237070:1
so has part: feature:236141-237070:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:236141-237070:1:exon

YKL107W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL107W
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:31115629]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31115629]
experiment: EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:31115629]
note: NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family
codon start: 1
product: putative short-chain dehydrogenase/reductase
translation: MFWKKDPTVSWERKNINDIDFSRFNVAIIGGTGGLGRAISRELAQRNARVTVVGQTFRDEDLKDKINFVKADLSLVSECKRISHSDEIPYEELTHLIFTTGIFASRQRQATSEGLEKDMAVSYLSRYIIFHDVAKRLGISRTKKDDLPKVFIAGFPGNGQVGDPDDLNSDEKKYSAYATHMNTVAANESLVIDAKDRYTNIDTFGLNPGLIKTNIRNNLLGSDTYLSRITEWIISWTCQSAETYAKTICTLIASPAIESRSGTMFSNKGDAILPSPGLTKDVVEKFMENSELLVEKALRNQSPFTSSNE
SIO_010081: YKL107W
subclass of: SO_0000673
so part of: YKL107W
location: 236141..237070
location: region:236141-237070:1
so has part: feature:236141-237070:1:exon

NP_012815.1
type: Protein
SIO_000068: ncbiprotein

S000001590
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:236141-237070:1:exon

YKL106C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL106C-A
so part of: sequence
location: complement(<237147..>237266)
location: region:237147-237266:-1
so has part: feature:237147-237266:-1:exon
subclass of: SO_0000010

853754
type: Gene
SIO_000068: ncbigene

position:237147:-1
position: 237147
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237266:-1
position: 237266
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:237147-237266:-1:exon

YKL106C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL106C-A
product: uncharacterized protein
transcript id: NM_001184482.1
SIO_010081: YKL106C-A
subclass of: SO_0000673
so part of: YKL106C-A
location: complement(<237147..>237266)
location: region:237147-237266:-1
so has part: feature:237147-237266:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:237147-237266:-1:exon

YKL106C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL106C-A
note: hypothetical protein; identified by homology to uncharacterized proteins in other fungi
codon start: 1
product: uncharacterized protein
translation: MPFPSILHLTIGRYASYDSNNHMRRRAKLMEAIFRIRTI
SIO_010081: YKL106C-A
subclass of: SO_0000673
so part of: YKL106C-A
location: complement(237147..237266)
location: region:237147-237266:-1
so has part: feature:237147-237266:-1:exon

NP_076898.1
type: Protein
SIO_000068: ncbiprotein

S000007616
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:237147-237266:-1:exon

YKL106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAT1
locus tag: YKL106W
so part of: sequence
location: <237536..>238891
location: region:237536-238891:1
so has part: feature:237536-238891:1:exon
subclass of: SO_0000010

853755
type: Gene
SIO_000068: ncbigene

position:237536:1
position: 237536
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238891:1
position: 238891
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:237536-238891:1:exon

YKL106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAT1
locus tag: YKL106W
product: aspartate transaminase AAT1
transcript id: NM_001179672.1
SIO_010081: YKL106W
subclass of: SO_0000673
so part of: YKL106W
location: <237536..>238891
location: region:237536-238891:1
so has part: feature:237536-238891:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:237536-238891:1:exon

YKL106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAT1
locus tag: YKL106W
EC number: 2.6.1.1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:22010850]
experiment: EXISTENCE:mutant phenotype:GO:1901605 alpha-amino acid metabolic process [PMID:33397945]
note: Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
codon start: 1
product: aspartate transaminase AAT1
translation: MLRTRLTNCSLWRPYYTSSLSRVPRAPPDKVLGLSEHFKKVKNVNKIDLTVGIYKDGWGKVTTFPSVAKAQKLIESHLELNKNLSYLPITGSKEFQENVMKFLFKESCPQFGPFYLAHDRISFVQTLSGTGALAVAAKFLALFISRDIWIPDPSWANHKNIFQNNGFENIYRYSYYKDGQIDIDGWIEQLKTFAYNNQQENNKNPPCIILHACCHNPTGLDPTKEQWEKIIDTIYELKMVPIVDMAYQGLESGNLLKDAYLLRLCLNVNKYPNWSNGIFLCQSFAKNMGLYGERVGSLSVITPATANNGKFNPLQQKNSLQQNIDSQLKKIVRGMYSSPPGYGSRVVNVVLSDFKLKQQWFKDVDFMVQRLHHVRQEMFDRLGWPDLVNFAQQHGMFYYTRFSPKQVEILRNNYFVYLTGDGRLSLSGVNDSNVDYLCESLEAVSKMDKLA
SIO_010081: YKL106W
subclass of: SO_0000673
so part of: YKL106W
location: 237536..238891
location: region:237536-238891:1
so has part: feature:237536-238891:1:exon

NP_012816.1
type: Protein
SIO_000068: ncbiprotein

S000001589
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:237536-238891:1:exon

YKL105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEG2
locus tag: YKL105C
so part of: sequence
location: complement(<239185..>242583)
location: region:239185-242583:-1
so has part: feature:239185-242583:-1:exon
subclass of: SO_0000010

853756
type: Gene
SIO_000068: ncbigene

position:239185:-1
position: 239185
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:242583:-1
position: 242583
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:239185-242583:-1:exon

YKL105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEG2
locus tag: YKL105C
product: Seg2p
transcript id: NM_001179671.1
SIO_010081: YKL105C
subclass of: SO_0000673
so part of: YKL105C
location: complement(<239185..>242583)
location: region:239185-242583:-1
so has part: feature:239185-242583:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239185-242583:-1:exon

YKL105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEG2
locus tag: YKL105C
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to A. gossypii SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication
codon start: 1
product: Seg2p
translation: MIQESSPDALAAAAAIGNALSYNGRTVDKSKIPQYNQSFTSRTTSIAGINRYTMLSNSRTNSRMLLMNGNVRQYSKRTSSLPNQGHKNTSNNSAGRRQHRAHEDAETTFREFGGKQSSKVLNISSSTGQNSKSRTTSLGNSGSTIRTIKKYIPGPRGLMAVEVPVEVEPPRYSLSNRSNQRGGRAYSLPTRNNKTSLMHRNKTTKKAGSQEKKSESGGKSKNDYHGKVLSKMHTTSLKQRHNNVPLIPTTMNEETEQELQEDLHDPLEFKPMIISDDENSFIEPSVLDRSIPKKDKSGLSGREKKEEIETLLKEVHSLEEKISNIEIAKLNEEEREQSLILELRKVKLDEERRMELLKRELNIVKENADLEAQELKLIESKRKQHFHKGQEVASEVKSITIRQPTLSEPKPAYVPPEDVEKEPSTLSNQTQNIENAENIDSVDAEGNLVDPILLGSLNNSNFHMNSDNEVRCIADSNSLTGSELSDYNYIEGSATDLRATAKTSVESEIGGNQVGLKIPQDDDSEKQEERTKGKKSGLVDTNCFLVQKEDQEEALSDNEPESSEKFPSTSGIENVKLEDETGSVMDKNNGPNNDKDDDDDKDNDNDDDDDKDDDVNDDDKDENVDDDENVDDDDDDDDDDDDEYHDSYDVIMRDPVQIEQDISDVPSLKHPSEYSTETEDNKKKEQNSENAEVSQSGTNMAKYLRGANPYLTNTSSDTFSLDSENVNSKSSTDTTRVAPDLLKSSLQPQLRSDLKQSAVPSSTSSSIYSIETSPNIDSSTGKTASNTKTNSHGPPTSISKQKYDQSSSHQIPVMSPKRLDDKRKITNRSCLRTLRGSSNEATLSHNIVYPASDSSSSPPYHSKKPSNPPSSGNLASHEASKCFPKAPQASTTSRRLPDHVPLYIDKNNSALYPKEPPARKSSFEKERPAKDNLGFRSMSLREPLITKNATATAAENLDVEEKKEKGGHVSRKSWTFGLPSPLKRRTSHSTHTTNETEIVNPMTNFKNKTNENDMPILANKKSCNNDDSSPYTASSMNTNDVSEAGTEGHRFSLFGNKSQLSNRNISGGTATLESSNPDLPTALPLSVPVTIIDKNGEIHKLHNDDAAIKDKSHDRHGHSKFGRKLKKIFGRK
SIO_010081: YKL105C
subclass of: SO_0000673
so part of: YKL105C
location: complement(239185..242583)
location: region:239185-242583:-1
so has part: feature:239185-242583:-1:exon

NP_012817.1
type: Protein
SIO_000068: ncbiprotein

S000001588
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239185-242583:-1:exon

YKL104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GFA1
locus tag: YKL104C
so part of: sequence
location: complement(<243220..>245373)
location: region:243220-245373:-1
so has part: feature:243220-245373:-1:exon
subclass of: SO_0000010

853757
type: Gene
SIO_000068: ncbigene

position:243220:-1
position: 243220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245373:-1
position: 245373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243220-245373:-1:exon

YKL104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GFA1
locus tag: YKL104C
product: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
transcript id: NM_001179670.1
SIO_010081: YKL104C
subclass of: SO_0000673
so part of: YKL104C
location: complement(<243220..>245373)
location: region:243220-245373:-1
so has part: feature:243220-245373:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243220-245373:-1:exon

YKL104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GFA1
locus tag: YKL104C
EC number: 2.6.1.16
experiment: EXISTENCE:direct assay:GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity [PMID:2656689]
experiment: EXISTENCE:genetic interaction:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:11895440]
note: Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
codon start: 1
product: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
translation: MCGIFGYCNYLVERSRGEIIDTLVDGLQRLEYRGYDSTGIAIDGDEADSTFIYKQIGKVSALKEEITKQNPNRDVTFVSHCGIAHTRWATHGRPEQVNCHPQRSDPEDQFVVVHNGIITNFRELKTLLINKGYKFESDTDTECIAKLYLHLYNTNLQNGHDLDFHELTKLVLLELEGSYGLLCKSCHYPNEVIATRKGSPLLIGVKSEKKLKVDFVDVEFPEENAGQPEIPLKSNNKSFGLGPKKAREFEAGSQNANLLPIAANEFNLRHSQSRAFLSEDGSPTPVEFFVSSDAASVVKHTKKVLFLEDDDLAHIYDGELHIHRSRREVGASMTRSIQTLEMELAQIMKGPYDHFMQKEIYEQPESTFNTMRGRIDYENNKVILGGLKAWLPVVRRARRLIMIACGTSYHSCLATRAIFEELSDIPVSVELASDFLDRKCPVFRDDVCVFVSQSGETADTMLALNYCLERGALTVGIVNSVGSSISRVTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSDDRVSKIDRRIEIIQGLKLIPGQIKQVLKLEPRIKKLCATELKDQKSLLLLGRGYQFAAALEGALKIKEISYMHSEGVLAGELKHGVLALVDENLPIIAFGTRDSLFPKVVSSIEQVTARKGHPIIICNENDEVWAQKSKSIDLQTLEVPQTVDCLQGLINIIPLQLMSYWLAVNKGIDVDFPRNLAKSVTVE
SIO_010081: YKL104C
subclass of: SO_0000673
so part of: YKL104C
location: complement(243220..245373)
location: region:243220-245373:-1
so has part: feature:243220-245373:-1:exon

NP_012818.1
type: Protein
SIO_000068: ncbiprotein

S000001587
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243220-245373:-1:exon

YKL104W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL104W-A
so part of: sequence
location: <245032..>245286
location: region:245032-245286:1
so has part: feature:245032-245286:1:exon
subclass of: SO_0000010

65052911
type: Gene
SIO_000068: ncbigene

position:245032:1
position: 245032
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245286:1
position: 245286
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245032-245286:1:exon

YKL104W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL104W-A
product: uncharacterized protein
transcript id: NM_001395037.1
SIO_010081: YKL104W-A
subclass of: SO_0000673
so part of: YKL104W-A
location: <245032..>245286
location: region:245032-245286:1
so has part: feature:245032-245286:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245032-245286:1:exon

YKL104W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL104W-A
note: Novel ORF identified by enrichment-based proteomics
codon start: 1
product: uncharacterized protein
translation: MNDHKLVFWVRSLRVTVNLFWSTVSSPSSMRNTTMRDKSNVSVRILLSNLLFQSTHFTDLLIDESRISFVTIDSNTGGIIASIF
SIO_010081: YKL104W-A
subclass of: SO_0000673
so part of: YKL104W-A
location: 245032..245286
location: region:245032-245286:1
so has part: feature:245032-245286:1:exon

NP_001381967.1
type: Protein
SIO_000068: ncbiprotein

S000303811
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245032-245286:1:exon

YKL103C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: API
alternative label: LAP4
alternative label: YSC1
gene: APE1
locus tag: YKL103C
gene synonym: API; LAP4; YSC1
so part of: sequence
location: complement(<246138..>247682)
location: region:246138-247682:-1
so has part: feature:246138-247682:-1:exon
subclass of: SO_0000010

853758
type: Gene
SIO_000068: ncbigene

position:246138:-1
position: 246138
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:247682:-1
position: 247682
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246138-247682:-1:exon

YKL103C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: API
alternative label: LAP4
alternative label: YSC1
gene: APE1
locus tag: YKL103C
gene synonym: API; LAP4; YSC1
product: metalloaminopeptidase APE1
transcript id: NM_001179669.1
SIO_010081: YKL103C
subclass of: SO_0000673
so part of: YKL103C
location: complement(<246138..>247682)
location: region:246138-247682:-1
so has part: feature:246138-247682:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246138-247682:-1:exon

YKL103C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: API
alternative label: LAP4
alternative label: YSC1
gene: APE1
locus tag: YKL103C
gene synonym: API; LAP4; YSC1
EC number: 3.4.11.22
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:1400574]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:9151668|PMID:9412464|PMID:20659891]
experiment: EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:3882418]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:18725539]
note: Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to peptidase family M18; often used as marker in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway
codon start: 1
product: metalloaminopeptidase APE1
translation: MEEQREILEQLKKTLQMLTVEPSKNNQIANEEKEKKENENSWCILEHNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIGEDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFKDTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDSTPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDEEGNEPPTDDEKKSPLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFAPRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGAKGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYLKNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNNSRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNGFFKHWRSVYDEFGEL
SIO_010081: YKL103C
subclass of: SO_0000673
so part of: YKL103C
location: complement(246138..247682)
location: region:246138-247682:-1
so has part: feature:246138-247682:-1:exon

NP_012819.1
type: Protein
SIO_000068: ncbiprotein

S000001586
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246138-247682:-1:exon

YKL102C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL102C
so part of: sequence
location: complement(<248062..>248367)
location: region:248062-248367:-1
so has part: feature:248062-248367:-1:exon
subclass of: SO_0000010

853759
type: Gene
SIO_000068: ncbigene

position:248062:-1
position: 248062
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248367:-1
position: 248367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248062-248367:-1:exon

YKL102C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL102C
product: uncharacterized protein
transcript id: NM_001348849.1
SIO_010081: YKL102C
subclass of: SO_0000673
so part of: YKL102C
location: complement(<248062..>248367)
location: region:248062-248367:-1
so has part: feature:248062-248367:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248062-248367:-1:exon

YKL102C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL102C
note: hypothetical protein; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
codon start: 1
product: uncharacterized protein
translation: MCALFAEVSSTAAASCSFGVLLCSGSNCGRLVGSERRKVLYVFNVNVCKKMSSYYFLRHDNIVIPYLLRLLVSDKEASNKNPLLPFLMDKERSHHFVRNMN
SIO_010081: YKL102C
subclass of: SO_0000673
so part of: YKL102C
location: complement(248062..248367)
location: region:248062-248367:-1
so has part: feature:248062-248367:-1:exon

NP_001335789.1
type: Protein
SIO_000068: ncbiprotein

S000001585
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248062-248367:-1:exon

YKL101W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ELM2
alternative label: NIK1
gene: HSL1
locus tag: YKL101W
gene synonym: ELM2; NIK1
so part of: sequence
location: <248920..>253476
location: region:248920-253476:1
so has part: feature:248920-253476:1:exon
subclass of: SO_0000010

853760
type: Gene
SIO_000068: ncbigene

position:248920:1
position: 248920
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253476:1
position: 253476
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248920-253476:1:exon

YKL101W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ELM2
alternative label: NIK1
gene: HSL1
locus tag: YKL101W
gene synonym: ELM2; NIK1
product: protein kinase HSL1
transcript id: NM_001179667.2
SIO_010081: YKL101W
subclass of: SO_0000673
so part of: YKL101W
location: <248920..>253476
location: region:248920-253476:1
so has part: feature:248920-253476:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248920-253476:1:exon

YKL101W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ELM2
alternative label: NIK1
gene: HSL1
locus tag: YKL101W
gene synonym: ELM2; NIK1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:27053666|PMID:9925642]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:9925642|PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11408575]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10805747|PMID:15282802]
experiment: EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10490630]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:11408575]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:23042131]
experiment: EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9925642]
experiment: EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8647431]
experiment: EXISTENCE:mutant phenotype:GO:1902935 protein localization to septin ring [PMID:27053666]
experiment: EXISTENCE:physical interaction:GO:0000144 cellular bud neck septin ring [PMID:9925642]
note: Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p
codon start: 1
product: protein kinase HSL1
translation: MTGHVSKTSHVPKGRPSSLAKKAAKRAMAKVNSNPKRASGHLERVVQSVNDATKRLSQPDSTVSVATKSSKRKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDDLPVNKVLRKMRKDNMARGKSNSDLHLLNNVSPSIVTLHSKGEIDESILRSLQILWHGVSRELITAKLLQKPMSEEKLFYSLLLQYKQRHSISLSSSSENKKSATESSVNEPRIEYASKTANNTGLRSENNDVKTLHSLEIHSEDTSTVNQNNAITGVNTEINAPVLAQKSQFSINTLSQPESDKAEAEAVTLPPAIPIFNASSSRIFRNSYTSISSRSRRSLRLSNSRLSLSASTSRETVHDNEMPLPQLPKSPSRYSLSRRAIHASPSTKSIHKSLSRKNIAATVAARRTLQNSASKRSLYSLQSISKRSLNLNDLLVFDDPLPSKKPASENVNKSEPHSLESDSDFEILCDQILFGNALDRILEEEEDNEKERDTQRQRQNDTKSSADTFTISGVSTNKENEGPEYPTKIEKNQFNMSYKPSENMSGLSSFPIFEKENTLSSSYLEEQKPKRAALSDITNSFNKMNKQEGMRIEKKIQREQLQKKNDRPSPLKPIQHQELRVNSLPNDQGKPSLSLDPRRNISQPVNSKVESLLQGLKFKKEPASHWTHERGSLFMSEHVEDEKPVKASDVSIESSYVPLTTVATSSRDPSVLAESSTIQKPMLSLPSSFLNTSMTFKNLSQILADDGDDKHLSVPQNQSRSVAMSHPLRKQSAKISLTPRSNLNANLSVKRNQGSPGSYLSNDLDGISDMTFAMEIPTNTFTAQAIQLMNNDTDNNKINTSPKASSFTKEKVIKSAAYISKEKEPDNSDTNYIPDYTIPNTYDEKAINIFEDAPSDEGSLNTSSSESDSRASVHRKAVSIDTMATTNVLTPATNVRVSLYWNNNSSGIPRETTEEILSKLRLSPENPSNTHMQKRFSSTRGSRDSNALGISQSLQSMFKDLEEDQDGHTSQADILESSMSYSKRRPSEESVNPKQRVTMLFDEEEEESKKVGGGKIKEEHTKLDNKISEESSQLVLPVVEKKENANNTENNYSKIPKPSTIKVTKDTAMESNTQTHTKKPILKSVQNVEVEEAPSSDKKNWFVKLFQNFSSHNNATKASKNHVTNISFDDAHMLTLNEFNKNSIDYQLKNLDHKFGRKVVEYDCKFVKGNFKFKIKITSTPNASTVITVKKRSKHSNTSSNKAFEKFNDDVERVIRNAGRS
SIO_010081: YKL101W
subclass of: SO_0000673
so part of: YKL101W
location: 248920..253476
location: region:248920-253476:1
so has part: feature:248920-253476:1:exon

NP_012821.2
type: Protein
SIO_000068: ncbiprotein

S000001584
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248920-253476:1:exon

YKL100C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPF1
locus tag: YKL100C
so part of: sequence
location: complement(<253697..>255460)
location: region:253697-255460:-1
so has part: feature:253697-255460:-1:exon
subclass of: SO_0000010

853761
type: Gene
SIO_000068: ncbigene

position:253697:-1
position: 253697
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255460:-1
position: 255460
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253697-255460:-1:exon

YKL100C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPF1
locus tag: YKL100C
product: aspartic endopeptidase
transcript id: NM_001179666.1
SIO_010081: YKL100C
subclass of: SO_0000673
so part of: YKL100C
location: complement(<253697..>255460)
location: region:253697-255460:-1
so has part: feature:253697-255460:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253697-255460:-1:exon

YKL100C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPF1
locus tag: YKL100C
experiment: EXISTENCE:direct assay:GO:1990578 perinuclear endoplasmic reticulum membrane [PMID:25454947]
experiment: EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25454947]
experiment: EXISTENCE:mutant phenotype:GO:0042500 aspartic endopeptidase activity, intramembrane cleaving [PMID:25454947]
experiment: EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:25454947]
note: Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)
codon start: 1
product: aspartic endopeptidase
translation: MDKYLNSFVDHLSEWSSRAFRNNSSSANQSASNKELEQVFEQINAIVENHNNKLTTAFDKISYRVAHKITHLVESHSLVFNYATLVLIASALVVIGSFTSISSIPFTALPPTREHSLFDPTDFDVDHDCHVIYRENDEDKKKKKKSKRFFDMMDEKHAIILPLTSGCTLLALYFVIKKLHLNWLKYVVKILNFNITLLNIPAGTFVYSYFLNSLFRNLSHLASWNPLVVLPRYRVTIADDNEDLNKIGGFVTNLNYKDGLTNSVVHKKTLDEIEKDHWMKHFYRRELVEPKDIKSKRQISNMYLNSALIVSFVLSIVSTVYFYLSPNDWLISNAVSMNMAIWSIAQLKLKNLKSGALILIALFFYDICFVFGTDVMVTVATNLDIPVKLSLPVKFNTAQNNFNFSILGLGDIALPGMFIAMCYKYDIWKWHLDHDDTEFHFLNWSYVGKYFITAMVSYVASLVSAMVSLSIFNTAQPALLYIVPSLLISTILVACWNKDFKQFWNFQYDTIEVDKSLKKAIEKKENSITYSTFILSEYYNDADKYALLGDDVNENFDDDEEFVQEEDLSDSSEEELSEEDLLDDESS
SIO_010081: YKL100C
subclass of: SO_0000673
so part of: YKL100C
location: complement(253697..255460)
location: region:253697-255460:-1
so has part: feature:253697-255460:-1:exon

NP_012822.1
type: Protein
SIO_000068: ncbiprotein

S000001583
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253697-255460:-1:exon

YKL099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP11
locus tag: YKL099C
so part of: sequence
location: complement(<255720..>256472)
location: region:255720-256472:-1
so has part: feature:255720-256472:-1:exon
subclass of: SO_0000010

853762
type: Gene
SIO_000068: ncbigene

position:255720:-1
position: 255720
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256472:-1
position: 256472
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255720-256472:-1:exon

YKL099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP11
locus tag: YKL099C
product: rRNA-processing protein UTP11
transcript id: NM_001179665.1
SIO_010081: YKL099C
subclass of: SO_0000673
so part of: YKL099C
location: complement(<255720..>256472)
location: region:255720-256472:-1
so has part: feature:255720-256472:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255720-256472:-1:exon

YKL099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP11
locus tag: YKL099C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]
note: Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit
codon start: 1
product: rRNA-processing protein UTP11
translation: MAKLVHDVQKKQHRERSQLTSRSRYGFLEKHKDYVKRAQDFHRKQSTLKVLREKAKERNPDEYYHAMHSRKTDAKGLLISSRHGDEEDESLSMDQVKLLKTQDSNYVRTLRQIELKKLEKGAKQLMFKSSGNHTIFVDSREKMNEFTPEKFFNTTSEMVNRSENRLTKDQLAQDISNNRNASSIMPKESLDKKKLKKFKQVKQHLQRETQLKQVQQRMDAQRELLKKGSKKKIVDSSGKISFKWKKQRKR
SIO_010081: YKL099C
subclass of: SO_0000673
so part of: YKL099C
location: complement(255720..256472)
location: region:255720-256472:-1
so has part: feature:255720-256472:-1:exon

NP_012823.2
type: Protein
SIO_000068: ncbiprotein

S000001582
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255720-256472:-1:exon

YKL098W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTC2
locus tag: YKL098W
so part of: sequence
location: <256770..>257843
location: region:256770-257843:1
so has part: feature:256770-257843:1:exon
subclass of: SO_0000010

853763
type: Gene
SIO_000068: ncbigene

position:256770:1
position: 256770
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:257843:1
position: 257843
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256770-257843:1:exon

YKL098W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTC2
locus tag: YKL098W
product: Mtc2p
transcript id: NM_001179664.1
SIO_010081: YKL098W
subclass of: SO_0000673
so part of: YKL098W
location: <256770..>257843
location: region:256770-257843:1
so has part: feature:256770-257843:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256770-257843:1:exon

YKL098W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTC2
locus tag: YKL098W
note: hypothetical protein; mtc2 is synthetically sick with cdc13-1
codon start: 1
product: Mtc2p
translation: MGDHNLPDFQTCLKFSVTAKKSFLCMYRDSVSKEKLASSMPSTCDIQLKRAINDAYPGGGIKVTVLNSTTASLDSLATTHVKEFEIVIIPDINSLLQPDQAKLVKIMRDCTVAIEKAQSTRIFIGVVHWNNPVQPSGAAKDGDEAGKPAPKTRIFLPTSFRMGAWLKHKFWFACAPPYLDFESSTESSINTRANNSIGMAEEEKQEPESKRSIILNEEANLNDVFVGSTVRRYILDIMVHLRTHRLTYNAKAGGVYTNSLDDVVLLSRLIGLHSGKMFVSPSHVKEASRWYFPMHLELVQRSSMDSSLLYGSDPNLVDEMLEKLAKIKCEEVNEFENPLFLESLVVKNVLSKVVPPV
SIO_010081: YKL098W
subclass of: SO_0000673
so part of: YKL098W
location: 256770..257843
location: region:256770-257843:1
so has part: feature:256770-257843:1:exon

NP_012824.1
type: Protein
SIO_000068: ncbiprotein

S000001581
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256770-257843:1:exon

YKL097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL097C
so part of: sequence
location: complement(<258503..>258913)
location: region:258503-258913:-1
so has part: feature:258503-258913:-1:exon
subclass of: SO_0000010

853764
type: Gene
SIO_000068: ncbigene

position:258503:-1
position: 258503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:258913:-1
position: 258913
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:258503-258913:-1:exon

YKL097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL097C
product: uncharacterized protein
transcript id: NM_001348850.1
SIO_010081: YKL097C
subclass of: SO_0000673
so part of: YKL097C
location: complement(<258503..>258913)
location: region:258503-258913:-1
so has part: feature:258503-258913:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:258503-258913:-1:exon

YKL097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL097C
note: hypothetical protein; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species
codon start: 1
product: uncharacterized protein
translation: MFLFTFTILESEKLIIWPVPAVVLGVMAPKRAYSTPFGPWPGPAECLWNCPSELRQFSSCCLPLPKLRPPRPTFASLWRVVAAIAALFQVPWRRKTGVGKAIFCIGCCCLAYQWRRTRYFAYKIMTGTCFMTDLAP
SIO_010081: YKL097C
subclass of: SO_0000673
so part of: YKL097C
location: complement(258503..258913)
location: region:258503-258913:-1
so has part: feature:258503-258913:-1:exon

NP_001335790.1
type: Protein
SIO_000068: ncbiprotein

S000001580
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:258503-258913:-1:exon

YKL096C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL096C-B
so part of: sequence
location: complement(<259073..>259222)
location: region:259073-259222:-1
so has part: feature:259073-259222:-1:exon
subclass of: SO_0000010

1500486
type: Gene
SIO_000068: ncbigene

position:259073:-1
position: 259073
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259222:-1
position: 259222
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259073-259222:-1:exon

YKL096C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL096C-B
product: uncharacterized protein
transcript id: NM_001184604.1
SIO_010081: YKL096C-B
subclass of: SO_0000673
so part of: YKL096C-B
location: complement(<259073..>259222)
location: region:259073-259222:-1
so has part: feature:259073-259222:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:259073-259222:-1:exon

YKL096C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL096C-B
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MKLFILDYEKKRTKIGKGMARRELKMMNKKPDLYTIIVSYFSIFSLFFF
SIO_010081: YKL096C-B
subclass of: SO_0000673
so part of: YKL096C-B
location: complement(259073..259222)
location: region:259073-259222:-1
so has part: feature:259073-259222:-1:exon

NP_878110.1
type: Protein
SIO_000068: ncbiprotein

S000028667
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259073-259222:-1:exon

YKL096W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LPR1
alternative label: YKL097W-A
gene: CWP2
locus tag: YKL096W-A
gene synonym: LPR1; YKL097W-A
so part of: sequence
location: <259253..>259531
location: region:259253-259531:1
so has part: feature:259253-259531:1:exon
subclass of: SO_0000010

853765
type: Gene
SIO_000068: ncbigene

position:259253:1
position: 259253
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259531:1
position: 259531
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:259253-259531:1:exon

YKL096W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LPR1
alternative label: YKL097W-A
gene: CWP2
locus tag: YKL096W-A
gene synonym: LPR1; YKL097W-A
product: Cwp2p
transcript id: NM_001180025.1
SIO_010081: YKL096W-A
subclass of: SO_0000673
so part of: YKL096W-A
location: <259253..>259531
location: region:259253-259531:1
so has part: feature:259253-259531:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:259253-259531:1:exon

YKL096W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LPR1
alternative label: YKL097W-A
gene: CWP2
locus tag: YKL096W-A
gene synonym: LPR1; YKL097W-A
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:7768807]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747]
experiment: EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:7768807]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7768807|PMID:31537451]
note: Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
codon start: 1
product: Cwp2p
translation: MQFSTVASVAFVALANFVAAESAAAISQITDGQIQATTTATTEATTTAAPSSTVETVSPSSTETISQQTENGAAKAAVGMGAGALAAAAMLL
SIO_010081: YKL096W-A
subclass of: SO_0000673
so part of: YKL096W-A
location: 259253..259531
location: region:259253-259531:1
so has part: feature:259253-259531:1:exon

NP_012826.1
type: Protein
SIO_000068: ncbiprotein

S000001956
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:259253-259531:1:exon

YKL096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YJU1
gene: CWP1
locus tag: YKL096W
gene synonym: YJU1
so part of: sequence
location: <261132..>261851
location: region:261132-261851:1
so has part: feature:261132-261851:1:exon
subclass of: SO_0000010

853766
type: Gene
SIO_000068: ncbigene

position:261132:1
position: 261132
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:261851:1
position: 261851
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:261132-261851:1:exon

YKL096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YJU1
gene: CWP1
locus tag: YKL096W
gene synonym: YJU1
product: Cwp1p
transcript id: NM_001179662.1
SIO_010081: YKL096W
subclass of: SO_0000673
so part of: YKL096W
location: <261132..>261851
location: region:261132-261851:1
so has part: feature:261132-261851:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:261132-261851:1:exon

YKL096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YJU1
gene: CWP1
locus tag: YKL096W
gene synonym: YJU1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:7768807]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9335273|PMID:15781460]
experiment: EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:7768807]
experiment: EXISTENCE:direct assay:GO:0071597 cellular birth scar [PMID:16672383]
experiment: EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:18756268]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7768807]
note: Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to beta-1,3- and beta-1,6-glucan heteropolymer through phosphodiester bond; required for propionic acid resistance; targeted to vacuole via AP-3 pathway
codon start: 1
product: Cwp1p
translation: MKFSTALSVALFALAKMVIADSEEFGLVSIRSGSDLQYLSVYSDNGTLKLGSGSGSFEATITDDGKLKFDDDKYAVVNEDGSFKEGSESDAATGFSIKDGHLNYKSSSGFYAIKDGSSYIFSSKQSDDATGVAIRPTSKSGSVAADFSPSDSSSSSSASASSASASSSTKHSSSIESVETSTTVETSSASSPTASVISQITDGQIQAPNTVYEQTENAGAKAAVGMGAGALAVAAAYLL
SIO_010081: YKL096W
subclass of: SO_0000673
so part of: YKL096W
location: 261132..261851
location: region:261132-261851:1
so has part: feature:261132-261851:1:exon

NP_012827.1
type: Protein
SIO_000068: ncbiprotein

S000001579
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:261132-261851:1:exon

YKL095W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CWC16
gene: YJU2
locus tag: YKL095W
gene synonym: CWC16
so part of: sequence
location: <262277..>263113
location: region:262277-263113:1
so has part: feature:262277-263113:1:exon
subclass of: SO_0000010

853767
type: Gene
SIO_000068: ncbigene

position:262277:1
position: 262277
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263113:1
position: 263113
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:262277-263113:1:exon

YKL095W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CWC16
gene: YJU2
locus tag: YKL095W
gene synonym: CWC16
product: mRNA splicing protein YJU2
transcript id: NM_001179661.1
SIO_010081: YKL095W
subclass of: SO_0000673
so part of: YKL095W
location: <262277..>263113
location: region:262277-263113:1
so has part: feature:262277-263113:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:262277-263113:1:exon

YKL095W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CWC16
gene: YJU2
locus tag: YKL095W
gene synonym: CWC16
experiment: EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:17515604]
experiment: EXISTENCE:direct assay:GO:0000384 first spliceosomal transesterification activity [PMID:17515604]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:17515604]
note: Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing
codon start: 1
product: mRNA splicing protein YJU2
translation: MSERKAINKYYPPDYNPLEAEKLSRKMAKKLKTMNKSHASIRLMTPFSMRCLECNEYIPKSRKFNGKKELLKEKYLDSIKIYRLTISCPRCANSIAFRTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKTAVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLEMSQRAEMINRSKHAQQEKAVTTDDLDNLVDQVFDNHRQRTNKPGNNNDEKRTPLFNPTSTKGKIQKKSSVRTNPLGIVIKRGKSLK
SIO_010081: YKL095W
subclass of: SO_0000673
so part of: YKL095W
location: 262277..263113
location: region:262277-263113:1
so has part: feature:262277-263113:1:exon

NP_012828.1
type: Protein
SIO_000068: ncbiprotein

S000001578
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:262277-263113:1:exon

YKL094W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YJU3
locus tag: YKL094W
so part of: sequence
location: <263349..>264290
location: region:263349-264290:1
so has part: feature:263349-264290:1:exon
subclass of: SO_0000010

853768
type: Gene
SIO_000068: ncbigene

position:263349:1
position: 263349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:264290:1
position: 264290
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:263349-264290:1:exon

YKL094W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YJU3
locus tag: YKL094W
product: acylglycerol lipase
transcript id: NM_001179660.1
SIO_010081: YKL094W
subclass of: SO_0000673
so part of: YKL094W
location: <263349..>264290
location: region:263349-264290:1
so has part: feature:263349-264290:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:263349-264290:1:exon

YKL094W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YJU3
locus tag: YKL094W
EC number: 3.1.1.23
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:20554061|PMID:24868093]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:20554061]
experiment: EXISTENCE:direct assay:GO:0017171 serine hydrolase activity [PMID:14645503]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006641 triglyceride metabolic process [PMID:20554061]
experiment: EXISTENCE:mutant phenotype:GO:0047372 acylglycerol lipase activity [PMID:20554061]
note: Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters; required for removal of toxic metabolites in ethanol producing yeast cells; localizes to lipid particles and membranes; member of the eukaryotic serine hydrolase family; functional ortholog of mammalian MGL
codon start: 1
product: acylglycerol lipase
translation: MAPYPYKVQTTVPELQYENFDGAKFGYMFWPVQNGTNEVRGRVLLIHGFGEYTKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGRSKGVTDEYHVFNDLEHFVEKNLSECKAKGIPLFMWGHSMGGGICLNYACQGKHKNEISGYIGSGPLIILHPHTMYNKPTQIIAPLLAKFLPRVRIDTGLDLKGITSDKAYRAFLGSDPMSVPLYGSFRQIHDFMQRGAKLYKNENNYIQKNFAKDKPVIIMHGQDDTINDPKGSEKFIQDCPSADKELKLYPGARHSIFSLETDKVFNTVFNDMKQWLDKHTTTEAKP
SIO_010081: YKL094W
subclass of: SO_0000673
so part of: YKL094W
location: 263349..264290
location: region:263349-264290:1
so has part: feature:263349-264290:1:exon

NP_012829.1
type: Protein
SIO_000068: ncbiprotein

S000001577
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:263349-264290:1:exon

YKL093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MBR1
locus tag: YKL093W
so part of: sequence
location: <264789..>265808
location: region:264789-265808:1
so has part: feature:264789-265808:1:exon
subclass of: SO_0000010

853769
type: Gene
SIO_000068: ncbigene

position:264789:1
position: 264789
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:265808:1
position: 265808
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264789-265808:1:exon

YKL093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MBR1
locus tag: YKL093W
product: Mbr1p
transcript id: NM_001179659.1
SIO_010081: YKL093W
subclass of: SO_0000673
so part of: YKL093W
location: <264789..>265808
location: region:264789-265808:1
so has part: feature:264789-265808:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264789-265808:1:exon

YKL093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MBR1
locus tag: YKL093W
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8208248]
note: Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication
codon start: 1
product: Mbr1p
translation: MRMEKTTDKPLSAGDMNDEYSRGPIDDIDCLNFFERAVQDPCCEACDTEDADEELRAKLSSFNFQPDSSPCNAKCQQTLNPLCKIDEALPAESELAPSRNGSVSEANSDTNSIASTVHDPVDSKYGGMPSLRKAKTTSYFTSSSSNNTTMRNPLKKCNTNINGLLVNGRSSSSSRQSIPELFSGACTKKKNNVLLKSETPNSEFSSNSLQHCNSRSFSLPRSRSRSSAIAIPTHLYGLEKYVSPGLDTLTADPEESIERFSNNRPREISSCCPNDTGDTSSSLSHSNTSSSLNFPLGTNTNQFHQPRQPVQQQQSSKPNFGAGRKKSFIEMSLASSFAG
SIO_010081: YKL093W
subclass of: SO_0000673
so part of: YKL093W
location: 264789..265808
location: region:264789-265808:1
so has part: feature:264789-265808:1:exon

NP_012830.1
type: Protein
SIO_000068: ncbiprotein

S000001576
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264789-265808:1:exon

YKL092C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLA2
alternative label: ERC25
gene: BUD2
locus tag: YKL092C
gene synonym: CLA2; ERC25
so part of: sequence
location: complement(<266145..>269459)
location: region:266145-269459:-1
so has part: feature:266145-269459:-1:exon
subclass of: SO_0000010

853770
type: Gene
SIO_000068: ncbigene

position:266145:-1
position: 266145
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:269459:-1
position: 269459
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:266145-269459:-1:exon

YKL092C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLA2
alternative label: ERC25
gene: BUD2
locus tag: YKL092C
gene synonym: CLA2; ERC25
product: GTPase-activating protein BUD2
transcript id: NM_001179658.1
SIO_010081: YKL092C
subclass of: SO_0000673
so part of: YKL092C
location: complement(<266145..>269459)
location: region:266145-269459:-1
so has part: feature:266145-269459:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:266145-269459:-1:exon

YKL092C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLA2
alternative label: ERC25
gene: BUD2
locus tag: YKL092C
gene synonym: CLA2; ERC25
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10444589]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8371782]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10444589|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:2065354|PMID:22558355]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:2065354]
experiment: EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:23783029]
experiment: EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]
experiment: EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:22558355]
experiment: EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:23783029]
note: GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains
codon start: 1
product: GTPase-activating protein BUD2
translation: MSSNNEPAQSRTSYFKLNEFLSNVKHYKNTFKGEIQWCNNLSLNDWKTHYLQITSTGALTHSIDELTADSTNIQPIIKHLQQCRIEIIKDKHSSFKDINANCNFIIQVNTSGKDNKVYLRVKSWSDFKKLLTCLIWWSSMKTNGIFNKFQVSRPLEFKSKKMAKPESLLVYKLNVFGPIVKNIVLPPATNILESPDIINNDDNSVGWFSAMGVLKSNGMLDLLLQSDGSLIYSLNISQLLRSEIRILDSSVLQSENSLFLGELPLLRSQLGLEKFRIENIASAATNSSDISQEIIVEFPLRIDLEDCFIALQSFARSEYLSITGSDKSNDMKISNSFKISILEANFQSINLNDKNNTPWSIFTDITAWGHTWARTSMVSNSSNPFWREEFQFNELLRLTNSYLEIKQLFHDLNNKKRLRLIGKIKITQEIINDTRYNKETRLPIMDVDNKNFQIGTICIKISSNLNFILPSTNFVKLEKLLMNANLSMVSNLIYKSSSSMENDNKLTQTSIIFLDIFQSLSRIEEWFHVLIDKELAKIDGTVSRINQKNLDSKHVFNSLFRGNSILTKSIEQYFFRVGNEYLSKALSAILKEIIESNKSCELDPARVKEKDEVKKRKIIADNYKRLYSWVTKIWKRLYATSNDLPIEIRNVLKIFRQKLEIICIDDTLQIILNGISGLLFLRFFCPVILNPKLFKYVSQNLNETARRNLTLISKVLLNLSTLTQFANKEPWLMKMNNFIDKRHNDLLDYIDKMTQKKLDFNSKILNLSSTISRPKLAIEQTMLDDLPQIPYLLDKNLRETEFVNLIVNFSQEDMTKMEKYNHMDNGGKGELIEEEGLLSGSSLNLSVDKKDLDSPIEVKPEIGELEFEKITENNTEIFGDDLMNLLKSDDVGSRSRDLDNGANSGIKFNSIIPKAEEEKHAMKELEQESCLLYNRINHIRKRLSGYECASSTLFEDKKYSISLSHKIFYEEIKEGKEIVLKLLNKPTNENSSARLQKFFTKGVSSKSNNTVGDSYCKFLTIDVSDENPKSSNKTSVHGTSSENGAKDDYLTLPNSQGKGNLGNRFSPTKLSRIMRKPPNADVPKEQNSRKLTRWFKKKKETGGS
SIO_010081: YKL092C
subclass of: SO_0000673
so part of: YKL092C
location: complement(266145..269459)
location: region:266145-269459:-1
so has part: feature:266145-269459:-1:exon

NP_012831.1
type: Protein
SIO_000068: ncbiprotein

S000001575
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:266145-269459:-1:exon

YKL091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SFH1
locus tag: YKL091C
gene synonym: SFH1
so part of: sequence
location: complement(<269718..>270650)
location: region:269718-270650:-1
so has part: feature:269718-270650:-1:exon
subclass of: SO_0000010

853771
type: Gene
SIO_000068: ncbigene

position:269718:-1
position: 269718
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270650:-1
position: 270650
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:269718-270650:-1:exon

YKL091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SFH1
locus tag: YKL091C
gene synonym: SFH1
product: phosphatidylinositol/phosphatidylcholine-binding protein
transcript id: NM_001179657.1
SIO_010081: YKL091C
subclass of: SO_0000673
so part of: YKL091C
location: complement(<269718..>270650)
location: region:269718-270650:-1
so has part: feature:269718-270650:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:269718-270650:-1:exon

YKL091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SFH1
locus tag: YKL091C
gene synonym: SFH1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12869188]
experiment: EXISTENCE:direct assay:GO:0031210 phosphatidylcholine binding [PMID:18243114]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:18243114]
note: Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol/phosphatidylcholine-binding protein
translation: MTTSILDTYPQICSPNALPGTPGNLTKEQEEALLQFRSILLEKNYKERLDDSTLLRFLRARKFDINASVEMFVETERWREEYGANTIIEDYENNKEAEDKERIKLAKMYPQYYHHVDKDGRPLYFEELGGINLKKMYKITTEKQMLRNLVKEYELFATYRVPACSRRAGYLIETSCTVLDLKGISLSNAYHVLSYIKDVADISQNYYPERMGKFYIIHSPFGFSTMFKMVKPFLDPVTVSKIFILGSSYKKELLKQIPIENLPVKYGGTSVLHNPNDKFYYSDIGPWRDPRYIGPEGEIPNIFGKFTVTS
SIO_010081: YKL091C
subclass of: SO_0000673
so part of: YKL091C
location: complement(269718..270650)
location: region:269718-270650:-1
so has part: feature:269718-270650:-1:exon

NP_012832.1
type: Protein
SIO_000068: ncbiprotein

S000001574
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:269718-270650:-1:exon

YKL090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUE2
locus tag: YKL090W
so part of: sequence
location: <271878..>273209
location: region:271878-273209:1
so has part: feature:271878-273209:1:exon
subclass of: SO_0000010

853772
type: Gene
SIO_000068: ncbigene

position:271878:1
position: 271878
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273209:1
position: 273209
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271878-273209:1:exon

YKL090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUE2
locus tag: YKL090W
product: Cue2p
transcript id: NM_001179656.1
SIO_010081: YKL090W
subclass of: SO_0000673
so part of: YKL090W
location: <271878..>273209
location: region:271878-273209:1
so has part: feature:271878-273209:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271878-273209:1:exon

YKL090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUE2
locus tag: YKL090W
experiment: EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:31219035]
experiment: EXISTENCE:direct assay:GO:0006379 mRNA cleavage [PMID:31219035]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920|PMID:12787503]
experiment: EXISTENCE:direct assay:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31219035]
note: Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
codon start: 1
product: Cue2p
translation: MSMDNNDDHESKLSILMDMFPAISKSKLQVHLLENNNDLDLTIGLLLKENDDKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVESTISDLLNYETLQKLKDNQANSPDSVKRNEKKNNWESTNDHIESIIKFTDAPKNIAQEYLAENGFDTVKAIIKIILDYYDKRDFKKDVDTFKVKRSPNTTVRGGRVQSSTGLAHVLKKGKESANVAQESLKRPRSYKHSLDSPQMVELNELVADNRDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDDKNITKTWNFDEGFTLTSRDNCKQHLPKFSTPQISRRNEVGNTYKLPLHDKETPEGAVPVINNLFQTYRLDFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGRGIHSIGGISKVRLQVKSFLEKNHYIFWEESSYFRIEGKKKK
SIO_010081: YKL090W
subclass of: SO_0000673
so part of: YKL090W
location: 271878..273209
location: region:271878-273209:1
so has part: feature:271878-273209:1:exon

NP_012833.1
type: Protein
SIO_000068: ncbiprotein

S000001573
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271878-273209:1:exon

YKL089W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIF2
locus tag: YKL089W
so part of: sequence
location: <273394..>275043
location: region:273394-275043:1
so has part: feature:273394-275043:1:exon
subclass of: SO_0000010

853773
type: Gene
SIO_000068: ncbigene

position:273394:1
position: 273394
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:275043:1
position: 275043
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:273394-275043:1:exon

YKL089W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIF2
locus tag: YKL089W
product: Mif2p
transcript id: NM_001179655.1
SIO_010081: YKL089W
subclass of: SO_0000673
so part of: YKL089W
location: <273394..>275043
location: region:273394-275043:1
so has part: feature:273394-275043:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:273394-275043:1:exon

YKL089W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIF2
locus tag: YKL089W
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:9407032]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:9407032|PMID:18701705]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:14581449]
experiment: EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:22561346]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:8408221]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8408221]
experiment: EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:18701705]
note: Centromeric CDEIII region binding protein; nucleates kinetochore assembly; required for the structural integrity of elongating spindles; copurifies with subunits of the MIND complex and centromeric nucleosome components (Cse4p and histones H2A, H2B, and H4); phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; localizes to the kinetochore
codon start: 1
product: Mif2p
translation: MDYMKLGLKSRKTGIDVKQDIPKDEYSMENIDDFFKDDETSLISMRRKSRRKSSLFLPSTLNGDTKNVLPPFLQSYKSQDDEVVQSPSGKGDGSRRSSLLSHQSNFLSPANDFEPIEEEPEQEENDIRGNDFATPITQKLSKPTYKRKYSTRYSLDTSESPSVRLTPDRITNKNVYSDVPDLVADEDDDDRVNTSLNTSDNALLEDELEDDGFIPESEEDGDYIESDSSLDSGSDSASDSDGDNTYQEVEEEAEVNTNDNEDDYIRRQASDVVRTDSIIDRNGLRKSTRVKVAPLQYWRNEKIVYKRKSNKPVLDIDKIVTYDESEDEEEILAAQRRKKQKKKPTPTRPYNYVPTGRPRGRPKKDPNAKENLIPEDPNEDIIERIESGGIENGEWLKHGILEANVKISDTKEETKDEIIAFAPNLSQTEQVKDTKDENFALEIMFDKHKEYFASGILKLPAISGQKKLSNSFRTYITFHVIQGIVEVTVCKNKFLSVKGSTFQIPAFNEYAIANRGNDEAKMFFVQVTVSEDANDDNDKELDSTFDTFG
SIO_010081: YKL089W
subclass of: SO_0000673
so part of: YKL089W
location: 273394..275043
location: region:273394-275043:1
so has part: feature:273394-275043:1:exon

NP_012834.1
type: Protein
SIO_000068: ncbiprotein

S000001572
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:273394-275043:1:exon

YKL088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAB3
locus tag: YKL088W
so part of: sequence
location: <275283..>276998
location: region:275283-276998:1
so has part: feature:275283-276998:1:exon
subclass of: SO_0000010

853774
type: Gene
SIO_000068: ncbigene

position:275283:1
position: 275283
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276998:1
position: 276998
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:275283-276998:1:exon

YKL088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAB3
locus tag: YKL088W
product: phosphopantothenoylcysteine decarboxylase complex subunit CAB3
transcript id: NM_001179654.1
SIO_010081: YKL088W
subclass of: SO_0000673
so part of: YKL088W
location: <275283..>276998
location: region:275283-276998:1
so has part: feature:275283-276998:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:275283-276998:1:exon

YKL088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAB3
locus tag: YKL088W
experiment: EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]
experiment: EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19266201|PMID:19915539]
experiment: EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
note: Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC
codon start: 1
product: phosphopantothenoylcysteine decarboxylase complex subunit CAB3
translation: MTDEKVNSDQNMNGKQGVNLISSLPTTQVPVSILTNKERRKSIHDESNFERSDSHEDQSKSNSNRRNIYKNDYSTNLRDFSFANLKQNSERNKDGHEIQINTSMPANTNGQQKRFSPSLPSAVSFTVPEVERLPYHRYSISNKPGKQQQQQEQLQQNQQQEEQQKAQLQEQNQRAKQQEEVKQIQEQVQKKQTERQQLIDEKERIANAIFKENTTNDGTDIRKHSVSSGTSNSEDEVDSPSMEKNSIVHMPGDFIYFNPKSNASKPITAKAAPLSANNSTHKNKEVITAPTGPRVPFTEFFQKEDDKKFHILIGATGSVATIKVPLIIDKLFKIYGPEKISIQLIVTKPAEHFLKGLKMSTHVKIWREEDAWVFDAVNKNDTSLSLNLILHHELRKWADIFLIAPLSANTLAKLANGICNNLLTSVMRDWSPLTPVLIAPAMNTFMYINPMTKKHLTSLVQDYPFIQVLKPVEKVLICGDIGMGGMREWTDIVEIVRRRINEIRKARDEETGDKEQEQEEQEGADNEDDDDEDDEEDEEDEEEEEALNETASDESNDEEDEEDEEDVKTEV
SIO_010081: YKL088W
subclass of: SO_0000673
so part of: YKL088W
location: 275283..276998
location: region:275283-276998:1
so has part: feature:275283-276998:1:exon

NP_012835.1
type: Protein
SIO_000068: ncbiprotein

S000001571
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:275283-276998:1:exon

YKL087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CYT2
locus tag: YKL087C
so part of: sequence
location: complement(<277189..>277863)
location: region:277189-277863:-1
so has part: feature:277189-277863:-1:exon
subclass of: SO_0000010

853775
type: Gene
SIO_000068: ncbigene

position:277189:-1
position: 277189
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:277863:-1
position: 277863
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:277189-277863:-1:exon

YKL087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CYT2
locus tag: YKL087C
product: cytochrome c1 heme lyase CYT2
transcript id: NM_001179653.1
SIO_010081: YKL087C
subclass of: SO_0000673
so part of: YKL087C
location: complement(<277189..>277863)
location: region:277189-277863:-1
so has part: feature:277189-277863:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:277189-277863:-1:exon

YKL087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CYT2
locus tag: YKL087C
EC number: 4.4.1.17
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:7559417]
experiment: EXISTENCE:mutant phenotype:GO:0004408 holocytochrome-c synthase activity [PMID:1499554]
experiment: EXISTENCE:mutant phenotype:GO:0018063 cytochrome c-heme linkage [PMID:1499554]
note: Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant
codon start: 1
product: cytochrome c1 heme lyase CYT2
translation: MMSSDQQGKCPVDEETKKLWLREHGNEAHPGATAPGNQLECSANPQDNDKTPEYHTTVDLSQSREVSTIPRTNSDRNWIYPSEKQFYEAMMKKNWDPNSDDMKVVVPLHNSINERVWNYIKSWEDKQGGEACGGIKLTNFKGDSKKLTPRAWFRSRILHLAKPFDRHDWQIDRCGKTVDYVIDFYSTDLNDANSQQQPLIYLDVRPKLNSFEGFRLRFWKSLGF
SIO_010081: YKL087C
subclass of: SO_0000673
so part of: YKL087C
location: complement(277189..277863)
location: region:277189-277863:-1
so has part: feature:277189-277863:-1:exon

NP_012836.1
type: Protein
SIO_000068: ncbiprotein

S000001570
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:277189-277863:-1:exon

YKL086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRX1
locus tag: YKL086W
so part of: sequence
location: <278281..>278664
location: region:278281-278664:1
so has part: feature:278281-278664:1:exon
subclass of: SO_0000010

853776
type: Gene
SIO_000068: ncbigene

position:278281:1
position: 278281
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:278664:1
position: 278664
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278281-278664:1:exon

YKL086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRX1
locus tag: YKL086W
product: sulfiredoxin
transcript id: NM_001179652.1
SIO_010081: YKL086W
subclass of: SO_0000673
so part of: YKL086W
location: <278281..>278664
location: region:278281-278664:1
so has part: feature:278281-278664:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278281-278664:1:exon

YKL086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRX1
locus tag: YKL086W
EC number: 1.8.98.2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032542 sulfiredoxin activity [PMID:14586471]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14586471]
note: Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress
codon start: 1
product: sulfiredoxin
translation: MSLQSNSVKPTEIPLSEIRRPLAPVLDPQKIDAMVATMKGIPTASKTCSLEQAEAAASAGELPPVDVLGVRVKGQTLYYAFGGCHRLQAYDRRARETQNAAFPVRCRVLPATPRQIRMYLGSSLDIE
SIO_010081: YKL086W
subclass of: SO_0000673
so part of: YKL086W
location: 278281..278664
location: region:278281-278664:1
so has part: feature:278281-278664:1:exon

NP_012837.1
type: Protein
SIO_000068: ncbiprotein

S000001569
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278281-278664:1:exon

YKL085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDH1
locus tag: YKL085W
so part of: sequence
location: <279123..>280127
location: region:279123-280127:1
so has part: feature:279123-280127:1:exon
subclass of: SO_0000010

853777
type: Gene
SIO_000068: ncbigene

position:279123:1
position: 279123
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280127:1
position: 280127
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:279123-280127:1:exon

YKL085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDH1
locus tag: YKL085W
product: malate dehydrogenase MDH1
transcript id: NM_001179651.1
SIO_010081: YKL085W
subclass of: SO_0000673
so part of: YKL085W
location: <279123..>280127
location: region:279123-280127:1
so has part: feature:279123-280127:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:279123-280127:1:exon

YKL085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDH1
locus tag: YKL085W
EC number: 1.1.1.37
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9774331]
experiment: EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase activity [PMID:1898005]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10777592]
experiment: EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:3312168]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3312168]
experiment: EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase activity [PMID:10777592]
experiment: EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]
note: Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; mutation in human homolog MDH2 causes early-onset severe encephalopathy
codon start: 1
product: malate dehydrogenase MDH1
translation: MLSRVAKRAFSSTVANPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATDLSHIPTNSVVKGFTPEEPDGLNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPVNSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFISEVENTDPTQERVNVIGGHSGITIIPLISQTNHKLMSDDKRHELIHRIQFGGDEVVKAKNGAGSATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIEFFASPVTLGPDGIEKIHPIGELSSEEEEMLQKCKETLKKNIEKGVNFVASK
SIO_010081: YKL085W
subclass of: SO_0000673
so part of: YKL085W
location: 279123..280127
location: region:279123-280127:1
so has part: feature:279123-280127:1:exon

NP_012838.1
type: Protein
SIO_000068: ncbiprotein

S000001568
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:279123-280127:1:exon

YKL084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HOT13
locus tag: YKL084W
so part of: sequence
location: <280509..>280859
location: region:280509-280859:1
so has part: feature:280509-280859:1:exon
subclass of: SO_0000010

853778
type: Gene
SIO_000068: ncbigene

position:280509:1
position: 280509
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280859:1
position: 280859
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280509-280859:1:exon

YKL084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HOT13
locus tag: YKL084W
product: Hot13p
transcript id: NM_001179650.1
SIO_010081: YKL084W
subclass of: SO_0000673
so part of: YKL084W
location: <280509..>280859
location: region:280509-280859:1
so has part: feature:280509-280859:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280509-280859:1:exon

YKL084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HOT13
locus tag: YKL084W
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:15294910]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:18787558]
experiment: EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15294910]
note: Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
codon start: 1
product: Hot13p
translation: MIETAIYGKTVDDQSRCVHWHLPKDVIAIRFKCCDKYYACFECHQELSSHPLEKYDLLDDANKHLIICGVCRHEMTFAEYYDYNSNLICPNCRSPFNPGCKLHYHLYFQNPPPAMC
SIO_010081: YKL084W
subclass of: SO_0000673
so part of: YKL084W
location: 280509..280859
location: region:280509-280859:1
so has part: feature:280509-280859:1:exon

NP_012839.1
type: Protein
SIO_000068: ncbiprotein

S000001567
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280509-280859:1:exon

YKL082C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP14
locus tag: YKL082C
so part of: sequence
location: complement(<281025..>282329)
location: region:281025-282329:-1
so has part: feature:281025-282329:-1:exon
subclass of: SO_0000010

853780
type: Gene
SIO_000068: ncbigene

position:281025:-1
position: 281025
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:282329:-1
position: 282329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281025-282329:-1:exon

YKL082C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP14
locus tag: YKL082C
product: ribosome biosynthesis protein RRP14
transcript id: NM_001179648.1
SIO_010081: YKL082C
subclass of: SO_0000673
so part of: YKL082C
location: complement(<281025..>282329)
location: region:281025-282329:-1
so has part: feature:281025-282329:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281025-282329:-1:exon

YKL082C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP14
locus tag: YKL082C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11489916|PMID:17804645]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17272295|PMID:17804645]
experiment: EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:17272295]
note: Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
codon start: 1
product: ribosome biosynthesis protein RRP14
translation: MSNSLEERLRANSSAFDGLLALIPAKYYYDEKSQEQWKAKKKTKEQSKNDKLKKLDPEQRDDETSSTLEVMKKKEKDAKPVVLPGEKFKHMKMQKQKEATSKVEGDSDLNVEVNDPMIIAPDEDEEEEEDIKVIFDDEGNEIPLESKKDTTEPDRSVEKKSITEEEKLQRKKNLEALRSKLQAKISDMKSKRKAPGSREAILAQRKRKEELKKRKRLESEQEQDQDEIASDSDMEDIDSDLENNSKKRFKKGKKDSEINADGVMFQNIIFDDGARATSDLQRLRKAGRTKGPAKNDVKSHLKLLEAKKNKMEAKDELEQIKQKEKEKWQKAMLQAEGIKIRDDEKLLRKAIKRKEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRKDNKGKKRNKQEKMKRKYVGSAVPKKRAGFEGRLKTGKKKGGPK
SIO_010081: YKL082C
subclass of: SO_0000673
so part of: YKL082C
location: complement(281025..282329)
location: region:281025-282329:-1
so has part: feature:281025-282329:-1:exon

NP_012841.1
type: Protein
SIO_000068: ncbiprotein

S000001565
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281025-282329:-1:exon

YKL081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EFC1
gene: TEF4
locus tag: YKL081W
gene synonym: EFC1
so part of: sequence
location: <282891..>284455
location: region:282891-284455:1
so has part: feature:282891-284455:1:exon
subclass of: SO_0000010

853781
type: Gene
SIO_000068: ncbigene

position:282891:1
position: 282891
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:284455:1
position: 284455
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282891-284455:1:exon

YKL081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EFC1
gene: TEF4
locus tag: YKL081W
gene synonym: EFC1
product: translation elongation factor EF1B gamma
transcript id: NM_001179647.1
SIO_010081: YKL081W
subclass of: SO_0000673
so part of: YKL081W
location: join(<282891..283095,283422..>284455)
location: region:282891-284455:1
so has part: feature:282891-283095:1:exon
so has part: feature:283422-284455:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282891-283095:1:exon

position:283095:1
position: 283095
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:283422-284455:1:exon

position:283422:1
position: 283422
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EFC1
gene: TEF4
locus tag: YKL081W
gene synonym: EFC1
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:3528160]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006414 translational elongation [PMID:3528160]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23451152|PMID:26777405]
note: Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex
codon start: 1
product: translation elongation factor EF1B gamma
translation: MSQGTLYINRSPRNYASEALISYFKLDVKIVDLEQSSEFASLFPLKQAPAFLGPKGLKLTEALAIQFYLANQVADEKERARLLGSDVIEKSQILRWASLANSDVMSNIARPFLSFKGLIPYNKKDVDACFVKIDNLAAVFDARLRDYTFVATENISLGDLHAAGSWAFGLATILGPEWRAKHPHLMRWFNTVAASPIVKTPFAEVKLAEKALTYTPPKKQKAEKPKAEKSKAEKKKDEAKPADDAAPAKKPKHPLEALGKSTFVLDDWKRKYSNDDTRPVALPWFWEHYNPEEYSIWKVGYKYNDELTLTFMSNNLVGGFFNRLSASTKYMFGCLVVYGENNNNGIVGAVMVRGQDFAPAFDVAPDWESYEYTKLDPTKEEDKEFVNNMWAWDKPVVVNGEDKEIVDGKVLK
SIO_010081: YKL081W
subclass of: SO_0000673
so part of: YKL081W
location: join(282891..283095,283422..284455)
location: region:282891-284455:1
so has part: feature:282891-283095:1:exon
so has part: feature:283422-284455:1:exon

NP_012842.1
type: Protein
SIO_000068: ncbiprotein

S000001564
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282891-283095:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:283422-284455:1:exon

YNCK0009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR38
locus tag: YNCK0009W
so part of: sequence
location: 283185..283279
location: region:283185-283279:1
so has part: feature:283185-283279:1:exon
subclass of: SO_0000578

9164913
type: Gene
SIO_000068: ncbigene

position:283185:1
position: 283185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:283279:1
position: 283279
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:283185-283279:1:exon

YNCK0009W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR38
locus tag: YNCK0009W
product: SNR38
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:8674114]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:8674114]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position G2815
transcript id: NR_132200.1
SIO_010081: YNCK0009W
subclass of: SO_0000673
so part of: YNCK0009W
location: 283185..283279
location: region:283185-283279:1
so has part: feature:283185-283279:1:exon

S000007301
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:283185-283279:1:exon

YKL080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSL5
alternative label: VAT3
gene: VMA5
locus tag: YKL080W
gene synonym: CSL5; VAT3
so part of: sequence
location: <285030..>286208
location: region:285030-286208:1
so has part: feature:285030-286208:1:exon
subclass of: SO_0000010

853782
type: Gene
SIO_000068: ncbigene

position:285030:1
position: 285030
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286208:1
position: 286208
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285030-286208:1:exon

YKL080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSL5
alternative label: VAT3
gene: VMA5
locus tag: YKL080W
gene synonym: CSL5; VAT3
product: H(+)-transporting V1 sector ATPase subunit C
transcript id: NM_001179646.1
SIO_010081: YKL080W
subclass of: SO_0000673
so part of: YKL080W
location: <285030..>286208
location: region:285030-286208:1
so has part: feature:285030-286208:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:285030-286208:1:exon

YKL080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSL5
alternative label: VAT3
gene: VMA5
locus tag: YKL080W
gene synonym: CSL5; VAT3
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
note: Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits
codon start: 1
product: H(+)-transporting V1 sector ATPase subunit C
translation: MATALYTANDFILISLPQNAQPVTAPGSKTDSWFNETLIGGRAFVSDFKIPEFKIGSLDTLIVESEELSKVDNQIGASIGKIIEILQGLNETSTNAYRTLPINNMPVPEYLENFQWQTRKFKLDKSIKDLITLISNESSQLDADVRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVLNSEHLTTVLVAVPKSLKSDFEKSYETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAREKKFIPREFNYSEELIDQLKKEHDSAASLEQSLRVQLVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAVPPKNLSKCKSELIDAFGFLGGNAFMKDKKGKINKQDTSLHQYASLVDTEYEPFVMYIINL
SIO_010081: YKL080W
subclass of: SO_0000673
so part of: YKL080W
location: 285030..286208
location: region:285030-286208:1
so has part: feature:285030-286208:1:exon

NP_012843.1
type: Protein
SIO_000068: ncbiprotein

S000001563
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:285030-286208:1:exon

YKL079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMY1
locus tag: YKL079W
so part of: sequence
location: <286603..>288573
location: region:286603-288573:1
so has part: feature:286603-288573:1:exon
subclass of: SO_0000010

853783
type: Gene
SIO_000068: ncbigene

position:286603:1
position: 286603
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:288573:1
position: 288573
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286603-288573:1:exon

YKL079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMY1
locus tag: YKL079W
product: Smy1p
transcript id: NM_001179645.1
SIO_010081: YKL079W
subclass of: SO_0000673
so part of: YKL079W
location: <286603..>288573
location: region:286603-288573:1
so has part: feature:286603-288573:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:286603-288573:1:exon

YKL079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMY1
locus tag: YKL079W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8188749]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9472039|PMID:8188749]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8188749]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:8188749|PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0006904 vesicle docking involved in exocytosis [PMID:27307583]
experiment: EXISTENCE:mutant phenotype:GO:0003774 cytoskeletal motor activity [PMID:9472039]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27307583]
note: Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics
codon start: 1
product: Smy1p
translation: MHWNIISKEQSSSSVSLPTLDSSEPCHIEVILRAIPEKGLQNNESTFKIDPYENTVLFRTNNPLHETTKETHSTFQFDKVFDANATQEDVQKFLVHPIINDVLNGYNGTVITYGPSFSGKSYSLIGSKESEGILPNICKTLFDTLEKNEETKGDSFSVSVLAFEIYMEKTYDLLVPLPERKPLKLHRSSSKMDLEIKDICPAHVGSYEDLRSYIQAVQNVGNRMACGDKTERSRSHLVFQLHVEQRNRKDDILKNSSLYLVDLHGAEKFDKRTESTLSQDALKKLNQSIEALKNTVRSLSMKERDSAYSAKGSHSSAYRESQLTEVLKDSLGGNRKTKVILTCFLSNVPTTLSTLEFGDSIRQINNKVTDNTTGLNLKKKMDLFIQDMKIKDDNYVAQINILKAEIDSLKSLHNKSLPEDDEKKMLENTKKENIKLKLQLDSITQLLSSSTNEDPNNRIDEEVSEILTKRCEQIAQLELSFDRQMNSNSKLQQELEYKKSKEEALESMNVRLLEQIQLQEREIQELLTTNAILKGELETHTKLTETRSERIKSLESSVKELSLNKSAIPSPRRGSMSSSSGNTMLHIEEGSEISNSPWSANTSSKPLVWGARKVSSSSIATTGSQESFVARPFKKGLNLHSIKVTSSTPKSPSSGS
SIO_010081: YKL079W
subclass of: SO_0000673
so part of: YKL079W
location: 286603..288573
location: region:286603-288573:1
so has part: feature:286603-288573:1:exon

NP_012844.1
type: Protein
SIO_000068: ncbiprotein

S000001562
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:286603-288573:1:exon

YKL078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DHR2
locus tag: YKL078W
so part of: sequence
location: <288845..>291052
location: region:288845-291052:1
so has part: feature:288845-291052:1:exon
subclass of: SO_0000010

853784
type: Gene
SIO_000068: ncbigene

position:288845:1
position: 288845
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:291052:1
position: 291052
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288845-291052:1:exon

YKL078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DHR2
locus tag: YKL078W
product: RNA helicase
transcript id: NM_001179644.1
SIO_010081: YKL078W
subclass of: SO_0000673
so part of: YKL078W
location: <288845..>291052
location: region:288845-291052:1
so has part: feature:288845-291052:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288845-291052:1:exon

YKL078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DHR2
locus tag: YKL078W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:10982841]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10982841]
experiment: EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:10982841]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]
note: Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis
codon start: 1
product: RNA helicase
translation: MAANSNSRVASNHTSKKQKVRRNIHPFTNNTRIKRASKIVKFNDSGEGDHVSDQRSNKENVLTYKSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQINQGEELGDILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPEERDEVNERRLSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEPISIHPSSMLFMNKSCPGIMYTEYVFTTKGYARNVSRIELSWLQEVVTNAAAVAKQKVSDSK
SIO_010081: YKL078W
subclass of: SO_0000673
so part of: YKL078W
location: 288845..291052
location: region:288845-291052:1
so has part: feature:288845-291052:1:exon

NP_012845.1
type: Protein
SIO_000068: ncbiprotein

S000001561
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288845-291052:1:exon

YKL077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PSG1
locus tag: YKL077W
so part of: sequence
location: <291453..>292631
location: region:291453-292631:1
so has part: feature:291453-292631:1:exon
subclass of: SO_0000010

853785
type: Gene
SIO_000068: ncbigene

position:291453:1
position: 291453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292631:1
position: 292631
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:291453-292631:1:exon

YKL077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PSG1
locus tag: YKL077W
product: Psg1p
transcript id: NM_001179643.1
SIO_010081: YKL077W
subclass of: SO_0000673
so part of: YKL077W
location: <291453..>292631
location: region:291453-292631:1
so has part: feature:291453-292631:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:291453-292631:1:exon

YKL077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PSG1
locus tag: YKL077W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:28727280]
experiment: EXISTENCE:mutant phenotype:GO:0006605 protein targeting [PMID:28727280]
experiment: EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:28727280]
note: Protein that promotes the transport and maturation of Pma1 with Exp1; cleaved specifically by Kex2p; localizes to the Golgi apparatus and to the endoplasmic reticulum in HTP studies
codon start: 1
product: Psg1p
translation: MRFHDSILIFFSLASLYQHVHGARQVVRPKEKMTTSEEVKPWLRTVYGSQKELVTPTVIAGVTFSEKPEETPNPLKPWVSLEHDGRPKTIKPEINKGRTKKGRPDYSTYFKTVSSHTYSYEELKAHNMGPNEVFVEEEYIDEDDTYVSLNPIVRCTPNLYFNKGLAKDIRSEPFCTPYENSRWKVDKTYFVTWYTRFFTDENSGKVADKVRVHLSYVKENPVEKGNYKRDIPATFFSSEWIDNDNGLMPVEVRDEWLQDQFDRRIVVSVQPIYISDEDFDPLQYGILLYITKGSKVFKPTKEQLALDDAGITNDQWYYVALSIPTVVVVFFVFMYFFLYVNGKNRDFTDVTRKALNKKRRVLGKFSEMKKFKNMKNHKYTELPSYKKTSKQN
SIO_010081: YKL077W
subclass of: SO_0000673
so part of: YKL077W
location: 291453..292631
location: region:291453-292631:1
so has part: feature:291453-292631:1:exon

NP_012846.1
type: Protein
SIO_000068: ncbiprotein

S000001560
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:291453-292631:1:exon

YKL075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AAN1
locus tag: YKL075C
so part of: sequence
location: complement(<292956..>294308)
location: region:292956-294308:-1
so has part: feature:292956-294308:-1:exon
subclass of: SO_0000010

853787
type: Gene
SIO_000068: ncbigene

position:292956:-1
position: 292956
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:294308:-1
position: 294308
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292956-294308:-1:exon

YKL075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AAN1
locus tag: YKL075C
product: Aan1p
transcript id: NM_001179641.1
SIO_010081: YKL075C
subclass of: SO_0000673
so part of: YKL075C
location: complement(<292956..>294308)
location: region:292956-294308:-1
so has part: feature:292956-294308:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292956-294308:-1:exon

YKL075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AAN1
locus tag: YKL075C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:35577788]
experiment: EXISTENCE:mutant phenotype:GO:0009081 branched-chain amino acid metabolic process [PMID:35577788]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:16121259]
note: hypothetical protein; regulates actin cable stability and branched-chain amino acid (BCAA) metabolism; involved in mitochondrial quality control and longevity; proposed to be involved in resistance to streptozotocin and camptothecin; localizes to punctate cytosolic structures
codon start: 1
product: Aan1p
translation: MAKDLLPKQAANEPSLKDCTCKRCLKLGASKEKKIRRKKKGEEKRERHYGNRRKLTFNFLKHTNMENTNYDVITSVGYLNEKYGLKKSHYIEKFIKCIHRKINIDVSKITDAYVNSLNPWVKVKLFLLLVTLSEKGGPEYWLDKTDGEKNSEASSTDNSLENSTKGADSAGSTALRDEMVKSHKNLFPTLTEQIIQHNINQDFTESTYDEDYVFSSIWANFMEGLINHYLEKVIVPYSEMKVCQQLYKPMMKIISLYNEYNELMVKSEKNGFLPSLQDSENVQGDKGEKESKDDAVSQERLERAQKLLWQAREDIPKTISKELTLLSEMYSTLSADEQDYELDEFVCCAEEYIELEYLPALVDVLFANCGTNNFWKIMLVLEPFFYYIEDVGGDDDEDEDNVDNSEGDEESLLSRNVEGDDNVVERHFKPDPRVITLEKICEVAARQKWI
SIO_010081: YKL075C
subclass of: SO_0000673
so part of: YKL075C
location: complement(292956..294308)
location: region:292956-294308:-1
so has part: feature:292956-294308:-1:exon

NP_012848.1
type: Protein
SIO_000068: ncbiprotein

S000001558
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292956-294308:-1:exon

YKL074C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MUD2
locus tag: YKL074C
so part of: sequence
location: complement(<294610..>296193)
location: region:294610-296193:-1
so has part: feature:294610-296193:-1:exon
subclass of: SO_0000010

853788
type: Gene
SIO_000068: ncbigene

position:294610:-1
position: 294610
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296193:-1
position: 296193
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:294610-296193:-1:exon

YKL074C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MUD2
locus tag: YKL074C
product: Mud2p
transcript id: NM_001179640.1
SIO_010081: YKL074C
subclass of: SO_0000673
so part of: YKL074C
location: complement(<294610..>296193)
location: region:294610-296193:-1
so has part: feature:294610-296193:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:294610-296193:-1:exon

YKL074C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MUD2
locus tag: YKL074C
experiment: EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:7926772]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0045131 pre-mRNA branch point binding [PMID:7926772]
experiment: EXISTENCE:genetic interaction:GO:0000348 mRNA branch site recognition [PMID:18375978]
experiment: EXISTENCE:mutant phenotype:GO:0000243 commitment complex [PMID:7926772]
experiment: EXISTENCE:mutant phenotype:GO:0000348 mRNA branch site recognition [PMID:9130720]
note: Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
codon start: 1
product: Mud2p
translation: MADEKRLEDLRSKIMESIGKSEKDVVPIENKRFNTDNAVIDTHFKRQKSDGELPKAPKSRNVSHSNNRGPSSIITMSTNRTTYEQTRAGPHRQSYRDASGRSYNRENRYSSHNTGPQWNNNPYNRQRDERRGRNERFDRRGRNGNGNYDRFNYQRKNEGSKFNGDRDKRQLQTNKYDMNYNSQNVMYPGSSFDSPAYYNMASSKANSRLVISGLSQSSDPSIVARLKDLLENFISGLQKTESNAEDFKISNFYIGEGRPDHIIVEFSSQICSTMVLACRSFFNAKLGTFDLKWRRPNDYVQQLDHLVDFCRGTVIALENLENIGEGEDYRMKELFSSLNVTNGTAKPLFYKCSSNTNNTGKESEFTKCILLSFEVVTQDILDKLKPYKWFKPNDGKISQVTSWITFQSLPNLVTQSVRVESRVLLLLNCLDPLDLKDETFITEIKETLKYSIAGADTIKICQPGVDYRLNFENLASGAGNIYIKFKTLEAAKHAMEELPGTQFNDRTVLCTYIDEDDFDMMEATQLS
SIO_010081: YKL074C
subclass of: SO_0000673
so part of: YKL074C
location: complement(294610..296193)
location: region:294610-296193:-1
so has part: feature:294610-296193:-1:exon

NP_012849.1
type: Protein
SIO_000068: ncbiprotein

S000001557
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:294610-296193:-1:exon

YKL073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CER1
alternative label: SSI1
gene: LHS1
locus tag: YKL073W
gene synonym: CER1; SSI1
so part of: sequence
location: <296430..>299075
location: region:296430-299075:1
so has part: feature:296430-299075:1:exon
subclass of: SO_0000010

853789
type: Gene
SIO_000068: ncbigene

position:296430:1
position: 296430
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:299075:1
position: 299075
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:296430-299075:1:exon

YKL073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CER1
alternative label: SSI1
gene: LHS1
locus tag: YKL073W
gene synonym: CER1; SSI1
product: Hsp70 family chaperone LHS1
transcript id: NM_001179639.1
SIO_010081: YKL073W
subclass of: SO_0000673
so part of: YKL073W
location: <296430..>299075
location: region:296430-299075:1
so has part: feature:296430-299075:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:296430-299075:1:exon

YKL073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CER1
alternative label: SSI1
gene: LHS1
locus tag: YKL073W
gene synonym: CER1; SSI1
experiment: EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:14704430]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:19759005]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:8654361|PMID:8887673]
experiment: EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:19759005]
experiment: EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:8654361|PMID:8887673]
experiment: EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:8654361|PMID:8887673]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:10409721|PMID:8654361|PMID:8887673]
note: Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
codon start: 1
product: Hsp70 family chaperone LHS1
translation: MRNVLRLLFLTAFVAIGSLAAVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGSLATRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTNRSTIAFLVDNVEYPLEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPHLGGAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANSEASINIESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIPIVQDQLIKLVSEEKVLRNVNADESAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKLSNESELYDVFTRGSAYPNKTSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYSSDKCSSGVAYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQIKNKGSRLAFTSEDVEIKRLSPSERSRLHEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGPKSQVEELSEMVKVYLDWLEDASFDTDPEDIVSRIREIGILKKKIELYMDSAKEPLNSQQFKGMLEEGHKLLQAIETHKNTVEEFLSQFETEFADTIDNVREEFKKIKQPAYVSKALSTWEETLTSFKNSISEIEKFLAKNLFGEDLREHLFEIKLQFDMYRTKLEEKLRLIKSGDESRLNEIKKLHLRNFRLQKRKEEKLKRKLEQEKSRNNNETESTVINSADDKTTIVNDKTTESNPSSEEDILHDEL
SIO_010081: YKL073W
subclass of: SO_0000673
so part of: YKL073W
location: 296430..299075
location: region:296430-299075:1
so has part: feature:296430-299075:1:exon

NP_012850.1
type: Protein
SIO_000068: ncbiprotein

S000001556
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:296430-299075:1:exon

YKL072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STB6
locus tag: YKL072W
so part of: sequence
location: <299582..>301882
location: region:299582-301882:1
so has part: feature:299582-301882:1:exon
subclass of: SO_0000010

853790
type: Gene
SIO_000068: ncbigene

position:299582:1
position: 299582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301882:1
position: 301882
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:299582-301882:1:exon

YKL072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STB6
locus tag: YKL072W
product: Stb6p
transcript id: NM_001179638.1
SIO_010081: YKL072W
subclass of: SO_0000673
so part of: YKL072W
location: <299582..>301882
location: region:299582-301882:1
so has part: feature:299582-301882:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:299582-301882:1:exon

YKL072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STB6
locus tag: YKL072W
note: Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication
codon start: 1
product: Stb6p
translation: MQLEATHQKENHLSPLASFIFPDFRALFNIGFNLYSNINYKEVDINGFEIYIVEQWAAQRKISTLITSYTGNLQDTISAVEVALPEDPEEWPCCLKKYHEELLKFSSPKKTAKGTLFVTNLSSFKSTLNLLHVECGNLKKIWKNFKTNYDLKRLHCGGRSAQLLKKTPSASIAKFAQLYKFPNSAFSHEITSDFQQPSLQNDNSSISSIENIPVNHCPVVELTTLVQISLSYFALFEYKKERDGLLCNGTKQSLEKWWEIYGKRYHGIDKPKNETILGPTTVASLLSLVLTCYFKLMVEDCMSAKDPFDEEEFYSGLYAFQKKYGLSKNNKQTSLDELTIDKLFEVSSKTSNKDIFKFKKVVKSTVQDMTGKGNFMHLSNEILTTDLDTLVKNIHGGSLGKLWKGRSASRKETCMVWERKTFLSFKFERGDPSLQLENNELFYGTSVPSEQLTTSNKEDSDTQPTKRNSIYDIANGSKSSLSISSMFCNYDETRYKSTNNLNRAYRGEYFRRNSIPFCNDGIHDTKKISADLNKIDGLYRCNSYSEVQNAIELWSLPFDSSVIRLARDLLKIQSLMSVQRQLDEIRDGYLGKNSQRSYQNDLMFRQSLNKLQEMCERCKRGSNEFHWEYGNMQNKQQILESEKKDMKSLSSKLKYNVRILDRRVRDVEASVDHFDRKLEDVRKKLLEQNNSKDISMALESPCDKFEFDSFMDSIVQSQQTKYEGLCFKILDKKSLRKLKKEFWKWSTWTFDTFLYKNRPNKEKDTL
SIO_010081: YKL072W
subclass of: SO_0000673
so part of: YKL072W
location: 299582..301882
location: region:299582-301882:1
so has part: feature:299582-301882:1:exon

NP_012851.1
type: Protein
SIO_000068: ncbiprotein

S000001555
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:299582-301882:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(302334..302625)
location: region:302334-302625:-1
so has part: feature:302334-302625:-1:region

S000007052
type: SGD
SIO_000068: sgd

position:302334:-1
position: 302334
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:302625:-1
position: 302625
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302334-302625:-1:region

YNCK0010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0010W
so part of: sequence
location: 302918..303023
location: region:302918-303023:1
so has part: feature:302918-303023:1:exon
subclass of: SO_0000663

853791
type: Gene
SIO_000068: ncbigene

position:302918:1
position: 302918
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:303023:1
position: 303023
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302918-303023:1:exon

YNCK0010W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0010W
product: tRNA-Trp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Tryptophan tRNA (tRNA-Trp), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0010W
subclass of: SO_0000673
so part of: YNCK0010W
location: join(302918..302953,302988..303023)
location: region:302918-303023:1
so has part: feature:302918-302953:1:exon
so has part: feature:302988-303023:1:exon

S000006774
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302918-302953:1:exon

position:302953:1
position: 302953
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:302988-303023:1:exon

position:302988:1
position: 302988
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSI1
locus tag: YKL071W
so part of: sequence
location: <305114..>305884
location: region:305114-305884:1
so has part: feature:305114-305884:1:exon
subclass of: SO_0000010

853792
type: Gene
SIO_000068: ncbigene

position:305114:1
position: 305114
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:305884:1
position: 305884
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:305114-305884:1:exon

YKL071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSI1
locus tag: YKL071W
product: Osi1p
transcript id: NM_001179637.1
SIO_010081: YKL071W
subclass of: SO_0000673
so part of: YKL071W
location: <305114..>305884
location: region:305114-305884:1
so has part: feature:305114-305884:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:305114-305884:1:exon

YKL071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSI1
locus tag: YKL071W
experiment: EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:29034432]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0110095 cellular detoxification of aldehyde [PMID:19854918]
note: NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is upregulated in cells treated with the aldehydes furfural and glycolaldehyde, the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: Osi1p
translation: MNTSSRITYFIIGGSRGIGFNLVKILSASTGNTVITSIRGSPSLPKNKQVEDLAKIRKNIHIVQLDLTKDESIGNIADEIKKTPFFLGIDIFIACSAVSDSYYKVLETPKSVWLNHYSTNALGPILALQKVYPLLLLKKTRKIFFISSVAGSINAFVPLSVSAYGQSKAALNYAVKTLSFELKPEGFTVVAFHPGMVSTDMGQYGLDHFKEKNIDISGVNIITPEESASALIDVFRKILPEDNGKFFNYDGSEGVF
SIO_010081: YKL071W
subclass of: SO_0000673
so part of: YKL071W
location: 305114..305884
location: region:305114-305884:1
so has part: feature:305114-305884:1:exon

NP_012852.1
type: Protein
SIO_000068: ncbiprotein

S000001554
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:305114-305884:1:exon

YKL070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL070W
so part of: sequence
location: <306211..>306720
location: region:306211-306720:1
so has part: feature:306211-306720:1:exon
subclass of: SO_0000010

853793
type: Gene
SIO_000068: ncbigene

position:306211:1
position: 306211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:306720:1
position: 306720
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:306211-306720:1:exon

YKL070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL070W
product: uncharacterized protein
transcript id: NM_001179636.1
SIO_010081: YKL070W
subclass of: SO_0000673
so part of: YKL070W
location: <306211..>306720
location: region:306211-306720:1
so has part: feature:306211-306720:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:306211-306720:1:exon

YKL070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL070W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: uncharacterized protein
translation: MYIPKHFESMELSRYKLSKKPPLGTLFSSKASRQGFFGWRTSSNKDDPDFGMCASHIPFVFVEFDNGEHKLIAHLARKNKHVEMLERVQKCLVVFQSVDSYISPAWFPMKKKTHKFVPTWDFAAVHVYGTPRIIRDDKDWLINMLSTLTDQEEEKRPEGENVRSKVERF
SIO_010081: YKL070W
subclass of: SO_0000673
so part of: YKL070W
location: 306211..306720
location: region:306211-306720:1
so has part: feature:306211-306720:1:exon

NP_012853.1
type: Protein
SIO_000068: ncbiprotein

S000001553
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:306211-306720:1:exon

YKL069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKG9
locus tag: YKL069W
gene synonym: YKG9
so part of: sequence
location: <307285..>307827
location: region:307285-307827:1
so has part: feature:307285-307827:1:exon
subclass of: SO_0000010

853794
type: Gene
SIO_000068: ncbigene

position:307285:1
position: 307285
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:307827:1
position: 307827
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307285-307827:1:exon

YKL069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKG9
locus tag: YKL069W
gene synonym: YKG9
product: L-methionine (R)-S-oxide reductase
transcript id: NM_001179635.1
SIO_010081: YKL069W
subclass of: SO_0000673
so part of: YKL069W
location: <307285..>307827
location: region:307285-307827:1
so has part: feature:307285-307827:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307285-307827:1:exon

YKL069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKG9
locus tag: YKL069W
gene synonym: YKG9
EC number: 1.8.4.14
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070191 methionine-R-sulfoxide reductase activity [PMID:19049972]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19049972]
note: Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: L-methionine (R)-S-oxide reductase
translation: MGSSTGFHHADHVNYSSNLNKEEILEQLLLSYEGLSDGQVNWVCNLSNASSLIWHAYKSLAVDINWAGFYVTQASEENTLILGPFQGKVACQMIQFGKGVCGTAASTKETQIVPDVNKYPGHIACDGETKSEIVVPIISNDGKTLGVIDIDCLDYEGFDHVDKEFLEKLAKLINKSCVFK
SIO_010081: YKL069W
subclass of: SO_0000673
so part of: YKL069W
location: 307285..307827
location: region:307285-307827:1
so has part: feature:307285-307827:1:exon

NP_012854.1
type: Protein
SIO_000068: ncbiprotein

S000001552
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307285-307827:1:exon

YNCK0011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0011C
so part of: sequence
location: complement(308144..308217)
location: region:308144-308217:-1
so has part: feature:308144-308217:-1:exon
subclass of: SO_0000663

853795
type: Gene
SIO_000068: ncbigene

position:308144:-1
position: 308144
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:308217:-1
position: 308217
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:308144-308217:-1:exon

YNCK0011C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0011C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0011C
subclass of: SO_0000673
so part of: YNCK0011C
location: complement(308144..308217)
location: region:308144-308217:-1
so has part: feature:308144-308217:-1:exon

S000006760
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:308144-308217:-1:exon

YKL068W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL068W-A
so part of: sequence
location: <309206..>309442
location: region:309206-309442:1
so has part: feature:309206-309442:1:exon
subclass of: SO_0000010

1500487
type: Gene
SIO_000068: ncbigene

position:309206:1
position: 309206
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:309442:1
position: 309442
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:309206-309442:1:exon

YKL068W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL068W-A
product: uncharacterized protein
transcript id: NM_001184534.1
SIO_010081: YKL068W-A
subclass of: SO_0000673
so part of: YKL068W-A
location: <309206..>309442
location: region:309206-309442:1
so has part: feature:309206-309442:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:309206-309442:1:exon

YKL068W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL068W-A
note: hypothetical protein; identified by homology to Ashbya gossypii
codon start: 1
product: uncharacterized protein
translation: MQANHSVSYLYESSTSKRSNGLFSQTQKQGSFQKALSQTQEEIEDEDLMVDLNTGSLTPVKLKYWTQMSAMTEKFGKL
SIO_010081: YKL068W-A
subclass of: SO_0000673
so part of: YKL068W-A
location: 309206..309442
location: region:309206-309442:1
so has part: feature:309206-309442:1:exon

NP_878111.1
type: Protein
SIO_000068: ncbiprotein

S000028524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:309206-309442:1:exon

YKL068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSP100
gene: NUP100
locus tag: YKL068W
gene synonym: NSP100
so part of: sequence
location: <310199..>313078
location: region:310199-313078:1
so has part: feature:310199-313078:1:exon
subclass of: SO_0000010

853796
type: Gene
SIO_000068: ncbigene

position:310199:1
position: 310199
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:313078:1
position: 313078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310199-313078:1:exon

YKL068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSP100
gene: NUP100
locus tag: YKL068W
gene synonym: NSP100
product: FG-nucleoporin NUP100
transcript id: NM_001179634.1
SIO_010081: YKL068W
subclass of: SO_0000673
so part of: YKL068W
location: <310199..>313078
location: region:310199-313078:1
so has part: feature:310199-313078:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310199-313078:1:exon

YKL068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSP100
gene: NUP100
locus tag: YKL068W
gene synonym: NSP100
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:8195299]
experiment: EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19098896]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:20647373]
experiment: EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:20647373]
experiment: EXISTENCE:genetic interaction:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568]
experiment: EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
experiment: EXISTENCE:mutant phenotype:GO:2000238 regulation of tRNA export from nucleus [PMID:27932586]
experiment: EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11104765]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:19098896|PMID:12917401|PMID:17803941|PMID:17418788]
note: FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication
codon start: 1
product: FG-nucleoporin NUP100
translation: MFGNNRPMFGGSNLSFGSNTSSFGGQQSQQPNSLFGNSNNNNNSTSNNAQSGFGGFTSAAGSNSNSLFGNNNTQNNGAFGQSMGATQNSPFGSLNSSNASNGNTFGGSSSMGSFGGNTNNAFNNNSNSTNSPFGFNKPNTGGTLFGSQNNNSAGTSSLFGGQSTSTTGTFGNTGSSFGTGLNGNGSNIFGAGNNSQSNTTGSLFGNQQSSAFGTNNQQGSLFGQQSQNTNNAFGNQNQLGGSSFGSKPVGSGSLFGQSNNTLGNTTNNRNGLFGQMNSSNQGSSNSGLFGQNSMNSSTQGVFGQNNNQMQINGNNNNSLFGKANTFSNSASGGLFGQNNQQQGSGLFGQNSQTSGSSGLFGQNNQKQPNTFTQSNTGIGLFGQNNNQQQQSTGLFGAKPAGTTGSLFGGNSSTQPNSLFGTTNVPTSNTQSQQGNSLFGATKLTNMPFGGNPTANQSGSGNSLFGTKPASTTGSLFGNNTASTTVPSTNGLFGNNANNSTSTTNTGLFGAKPDSQSKPALGGGLFGNSNSNSSTIGQNKPVFGGTTQNTGLFGATGTNSSAVGSTGKLFGQNNNTLNVGTQNVPPVNNTTQNALLGTTAVPSLQQAPVTNEQLFSKISIPNSITNPVKATTSKVNADMKRNSSLTSAYRLAPKPLFAPSSNGDAKFQKWGKTLERSDRGSSTSNSITDPESSYLNSNDLLFDPDRRYLKHLVIKNNKNLNVINHNDDEASKVKLVTFTTESASKDDQASSSIAASKLTEKAHSPQTDLKDDHDESTPDPQSKSPNGSTSIPMIENEKISSKVPGLLSNDVTFFKNNYYISPSIETLGNKSLIELRKINNLVIGHRNYGKVEFLEPVDLLNTPLDTLCGDLVTFGPKSCSIYENCSIKPEKGEGINVRCRVTLYSCFPIDKETRKPIKNITHPLLKRSIAKLKENPVYKFESYDPVTGTYSYTIDHPVLT
SIO_010081: YKL068W
subclass of: SO_0000673
so part of: YKL068W
location: 310199..313078
location: region:310199-313078:1
so has part: feature:310199-313078:1:exon

NP_012855.1
type: Protein
SIO_000068: ncbiprotein

S000001551
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310199-313078:1:exon

YNCK0012C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0012C
so part of: sequence
location: complement(313401..313472)
location: region:313401-313472:-1
so has part: feature:313401-313472:-1:exon
subclass of: SO_0000663

853797
type: Gene
SIO_000068: ncbigene

position:313401:-1
position: 313401
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:313472:-1
position: 313472
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:313401-313472:-1:exon

YNCK0012C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0012C
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0012C
subclass of: SO_0000673
so part of: YNCK0012C
location: complement(313401..313472)
location: region:313401-313472:-1
so has part: feature:313401-313472:-1:exon

S000006598
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:313401-313472:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(313602..313919)
location: region:313602-313919:-1
so has part: feature:313602-313919:-1:region

S000007053
type: SGD
SIO_000068: sgd

position:313602:-1
position: 313602
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:313919:-1
position: 313919
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:313602-313919:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 314193..314524
location: region:314193-314524:1
so has part: feature:314193-314524:1:region

S000007057
type: SGD
SIO_000068: sgd

position:314193:1
position: 314193
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:314524:1
position: 314524
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314193-314524:1:region

YKL067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NDK1
gene: YNK1
locus tag: YKL067W
gene synonym: NDK1
so part of: sequence
location: <314812..>315273
location: region:314812-315273:1
so has part: feature:314812-315273:1:exon
subclass of: SO_0000010

853798
type: Gene
SIO_000068: ncbigene

position:314812:1
position: 314812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315273:1
position: 315273
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314812-315273:1:exon

YKL067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NDK1
gene: YNK1
locus tag: YKL067W
gene synonym: NDK1
product: nucleoside diphosphate kinase
transcript id: NM_001179633.1
SIO_010081: YKL067W
subclass of: SO_0000673
so part of: YKL067W
location: <314812..>315273
location: region:314812-315273:1
so has part: feature:314812-315273:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:314812-315273:1:exon

YKL067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NDK1
gene: YNK1
locus tag: YKL067W
gene synonym: NDK1
EC number: 2.7.4.6
experiment: EXISTENCE:direct assay:GO:0004550 nucleoside diphosphate kinase activity [PMID:12472466]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12472466]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12472466]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:18983998]
note: Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
codon start: 1
product: nucleoside diphosphate kinase
translation: MSSQTERTFIAVKPDGVQRGLVSQILSRFEKKGYKLVAIKLVKADDKLLEQHYAEHVGKPFFPKMVSFMKSGPILATVWEGKDVVRQGRTILGATNPLGSAPGTIRGDFGIDLGRNVCHGSDSVDSAEREINLWFKKEELVDWESNQAKWIYE
SIO_010081: YKL067W
subclass of: SO_0000673
so part of: YKL067W
location: 314812..315273
location: region:314812-315273:1
so has part: feature:314812-315273:1:exon

NP_012856.1
type: Protein
SIO_000068: ncbiprotein

S000001550
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:314812-315273:1:exon

YKL065W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPC7
locus tag: YKL065W-A
so part of: sequence
location: <315954..>316175
location: region:315954-316175:1
so has part: feature:315954-316175:1:exon
subclass of: SO_0000010

3799975
type: Gene
SIO_000068: ncbigene

position:315954:1
position: 315954
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316175:1
position: 316175
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:315954-316175:1:exon

YKL065W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPC7
locus tag: YKL065W-A
product: Dpc7p
transcript id: NM_001184684.1
SIO_010081: YKL065W-A
subclass of: SO_0000673
so part of: YKL065W-A
location: <315954..>316175
location: region:315954-316175:1
so has part: feature:315954-316175:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:315954-316175:1:exon

YKL065W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPC7
locus tag: YKL065W-A
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; SWAT-GFP fusion protein localizes to endoplasmic reticulum (ER) while mCherry fusion localizes to both ER and vacuole
codon start: 1
product: Dpc7p
translation: MRSNILKLLQRTSRRYVSSKDFEPVIGSNPKKQTSRLMVGSVGVMIPVLLYLFYKNDSKHSEIKKIYQNEKKI
SIO_010081: YKL065W-A
subclass of: SO_0000673
so part of: YKL065W-A
location: 315954..316175
location: region:315954-316175:1
so has part: feature:315954-316175:1:exon

NP_001032580.1
type: Protein
SIO_000068: ncbiprotein

S000113563
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:315954-316175:1:exon

YKL065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YET1
locus tag: YKL065C
so part of: sequence
location: complement(<316437..>317057)
location: region:316437-317057:-1
so has part: feature:316437-317057:-1:exon
subclass of: SO_0000010

853800
type: Gene
SIO_000068: ncbigene

position:316437:-1
position: 316437
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:317057:-1
position: 317057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316437-317057:-1:exon

YKL065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YET1
locus tag: YKL065C
product: Yet1p
transcript id: NM_001179631.2
SIO_010081: YKL065C
subclass of: SO_0000673
so part of: YKL065C
location: complement(<316437..>317057)
location: region:316437-317057:-1
so has part: feature:316437-317057:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316437-317057:-1:exon

YKL065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YET1
locus tag: YKL065C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20378542|PMID:14562095|PMID:26928762]
note: Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication
codon start: 1
product: Yet1p
translation: MSLYFTTLFLLLTVEMVMLFIFVLPLPFRIRRGIFSTYNQLTAKQQIKTIIFITGCLVGLLFIDSWKRSQIRVSLYHNDNSGSIGSSAVTPIQALASRAYNQRNMYISGFILYFSICIPTVMSIVKRLVKYQGLINEQEKQKLNKPSSNSKKDSNEADSTKLQEELRKKQISLEGLQKQVKNLEKYFDEKNQPGNVAAAEASKKGN
SIO_010081: YKL065C
subclass of: SO_0000673
so part of: YKL065C
location: complement(316437..317057)
location: region:316437-317057:-1
so has part: feature:316437-317057:-1:exon

NP_012858.2
type: Protein
SIO_000068: ncbiprotein

S000001548
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316437-317057:-1:exon

YKL064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MNR2
locus tag: YKL064W
so part of: sequence
location: <317764..>320673
location: region:317764-320673:1
so has part: feature:317764-320673:1:exon
subclass of: SO_0000010

853801
type: Gene
SIO_000068: ncbigene

position:317764:1
position: 317764
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:320673:1
position: 320673
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:317764-320673:1:exon

YKL064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MNR2
locus tag: YKL064W
product: putative Mg(2+) transporter MNR2
transcript id: NM_001179630.1
SIO_010081: YKL064W
subclass of: SO_0000673
so part of: YKL064W
location: <317764..>320673
location: region:317764-320673:1
so has part: feature:317764-320673:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:317764-320673:1:exon

YKL064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MNR2
locus tag: YKL064W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19720860|PMID:19001347|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]
experiment: EXISTENCE:mutant phenotype:GO:0010961 cellular magnesium ion homeostasis [PMID:19720860]
experiment: EXISTENCE:mutant phenotype:GO:0015095 magnesium ion transmembrane transporter activity [PMID:19720860]
note: Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)
codon start: 1
product: putative Mg(2+) transporter MNR2
translation: MSTDNSQKDEGVPLLSPYSSSPQLRKKKRNQKRRKDKFVGHLKSDSRRPTQLLHDNLQHNHGQITDFDQIDSWGMLHESDSTSNDIIKSEDPSLKGAFIDHRPSMSQPREGPQSVSSTVQPQPIMKFSTPSYKKPAGLRPSDQNRSLVSDLSPSELESWLKRRKSVHKSFVDENSPTDRRQSNANNDVVIDVDALMNHVNNNASTGVNDNSKRRKKKRGSDDSSNKNSKSTSSDSNDEEDEYNSRPSSSLSSNNSSLDDVCLVLDDEGSEVPKAWPDCTVLEEFSKEETERLRSQAIQDAEAFHFQYDEDEEDGTSNEDGILFSKPIVTNIDVPELGNRRVNETENLKNGRLRPKRIAPWHLIQRPMVLGSNSTKDSKSRIQSGLQDNLLVGRNIQYPPHIISNNPEHFRFTYFRVDLDSTVHSPTISGLLQPGQKFQDLFVASIYSQDNSAGHIKTHPNSPTPGIKAETVSQLQGLTAKNPSTLSSMSVANIEDVPPFWLDVSNPTEEEMKILSKAFGIHPLTTEDIFLGEVREKVELFRDYYLICFRSFDIVAEKHVRRRRKEKQESATLDHESISRRKSQAYGATMSNESNANNNNSTSNASRSKWLPSILRARRRSSANRTTNTSSSSYKRRVKSEKKKMEENEKFKRKSGDRHKPREGELEPLNVYIIVFRTGVLTFHFAPTPHPINVRRRARLLKDYLNVTSDWIAYALIDDITDAFAPMIELIEDEVYEIEDAILKMHQSDDSSDSDSSDSDSDSGASDEDAFPFDVYSKKTSYSSAKSSVSSRSMSTSEASFNANLIGWKRKGDMLRRIGECRKRVMSILRLLGSKADVIKGFAKRYNEQWEASPQSEIAMYLGDIQDHIVTMVSSLNHYEKLLSRSHSNYLAQINIDMTKVNNDMNDVLGKITILGTIVLPMNVITGLWGMNVIVPGQYRDSLTWFIGIVLFMCMLACSAYMYTKRRFGF
SIO_010081: YKL064W
subclass of: SO_0000673
so part of: YKL064W
location: 317764..320673
location: region:317764-320673:1
so has part: feature:317764-320673:1:exon

NP_012859.1
type: Protein
SIO_000068: ncbiprotein

S000001547
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:317764-320673:1:exon

YKL063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL063C
so part of: sequence
location: complement(<321015..>321518)
location: region:321015-321518:-1
so has part: feature:321015-321518:-1:exon
subclass of: SO_0000010

853802
type: Gene
SIO_000068: ncbigene

position:321015:-1
position: 321015
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321518:-1
position: 321518
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321015-321518:-1:exon

YKL063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL063C
product: uncharacterized protein
transcript id: NM_001179629.1
SIO_010081: YKL063C
subclass of: SO_0000673
so part of: YKL063C
location: complement(<321015..>321518)
location: region:321015-321518:-1
so has part: feature:321015-321518:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:321015-321518:-1:exon

YKL063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL063C
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
codon start: 1
product: uncharacterized protein
translation: MQGDIRRKKDLLPRYKTGSKYNSRRRGGYLTTPMKKIIVYIILLCGVYFVIKVAYSDLNKETEIKLESHSSDVSASASDHTNIAAGGAADATNNKQPQQAKVPKEKFNNEVAKQQEVKNLENDLKPQIDSEKQKQINKDKKEQKQQLQKEKQDLAKENLANNEILDN
SIO_010081: YKL063C
subclass of: SO_0000673
so part of: YKL063C
location: complement(321015..321518)
location: region:321015-321518:-1
so has part: feature:321015-321518:-1:exon

NP_012860.1
type: Protein
SIO_000068: ncbiprotein

S000001546
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:321015-321518:-1:exon

YKL062W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSN4
locus tag: YKL062W
so part of: sequence
location: <323228..>325120
location: region:323228-325120:1
so has part: feature:323228-325120:1:exon
subclass of: SO_0000010

853803
type: Gene
SIO_000068: ncbigene

position:323228:1
position: 323228
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:325120:1
position: 325120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323228-325120:1:exon

YKL062W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSN4
locus tag: YKL062W
product: stress-responsive transcriptional activator MSN4
transcript id: NM_001179628.1
SIO_010081: YKL062W
subclass of: SO_0000673
so part of: YKL062W
location: <323228..>325120
location: region:323228-325120:1
so has part: feature:323228-325120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323228-325120:1:exon

YKL062W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSN4
locus tag: YKL062W
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23435728|PMID:27637775]
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8321194|PMID:8641288]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12732613|PMID:9472026]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12732613|PMID:9472026]
experiment: EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:18070923]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:27637775|PMID:10652100|PMID:11102521|P MID:11179418|PMID:15053871|PMID:15483057|PMID:15922872|PMI D:16710843|PMID:17055490|PMID:17150183|PMID:17914901|PMID: 19073887|PMID:21749328|PMID:26947009|PMID:19702872|PMID:86 41288]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:27637775|PMID:8650168]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15922872|PMID:11102521]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27637775]
note: Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift
codon start: 1
product: stress-responsive transcriptional activator MSN4
translation: MLVFGPNSSFVRHANKKQEDSSIMNEPNGLMDPVLSTTNVSATSSNDNSANNSISSPEYTFGQFSMDSPHRTDATNTPILTATTNTTANNSLMNLKDTASLATNWKWKNSNNAQFVNDGEKQSSNANGKKNGGDKIYSSVATPQALNDELKNLEQLEKVFSPMNPINDSHFNENIELSPHQHATSPKTNLLEAEPSIYSNLFLDARLPNNANSTTGLNDNDYNLDDTNNDNTNSMQSILEDFVSSEEALKFMPDAGRDARRYSEVVTSSFPSMTDSRNSISHSIEFWNLNHKNSSNSKPTQQIIPEGTATTERRGSTISPTTTINNSNPNFKLLDHDVSQALSGYSMDFSKDSGITKPKSISSSLNRISHSSSTTRQQRASLPLIHDIESFANDSVMANPLSDSASFLSEENEDDAFGALNYNSLDATTMSAFDNNVDPFNILKSSPAQDQQFIKPSMMLSDNASAAAKLATSGVDNITPTPAFQRRSYDISMNSSFKILPTSQAHHAAQHHQQQPTKQATVSPNTRRRKSSSVTLSPTISHNNNNGKVPVQPRKRKSITTIDPNNYDKNKPFKCKDCEKAFRRSEHLKRHIRSVHSTERPFACMFCEKKFSRSDNLSQHLKTHKKHGDF
SIO_010081: YKL062W
subclass of: SO_0000673
so part of: YKL062W
location: 323228..325120
location: region:323228-325120:1
so has part: feature:323228-325120:1:exon

NP_012861.1
type: Protein
SIO_000068: ncbiprotein

S000001545
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323228-325120:1:exon

YKL061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BLI1
locus tag: YKL061W
so part of: sequence
location: <325771..>326112
location: region:325771-326112:1
so has part: feature:325771-326112:1:exon
subclass of: SO_0000010

853804
type: Gene
SIO_000068: ncbigene

position:325771:1
position: 325771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326112:1
position: 326112
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325771-326112:1:exon

YKL061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BLI1
locus tag: YKL061W
product: Bli1p
transcript id: NM_001179627.1
SIO_010081: YKL061W
subclass of: SO_0000673
so part of: YKL061W
location: <325771..>326112
location: region:325771-326112:1
so has part: feature:325771-326112:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325771-326112:1:exon

YKL061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BLI1
locus tag: YKL061W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]
note: Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome
codon start: 1
product: Bli1p
translation: MGEQNKLYYDVEKLVNSLQESFDLDCAQSVSLFTSKSRSNEAWLEELENKFKLKDDVELDDVENLRAEIDMKLNMLEDKVSYYERLYKELEEFQNEIKIKTVVNNRRQSRTPK
SIO_010081: YKL061W
subclass of: SO_0000673
so part of: YKL061W
location: 325771..326112
location: region:325771-326112:1
so has part: feature:325771-326112:1:exon

NP_012862.1
type: Protein
SIO_000068: ncbiprotein

S000001544
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325771-326112:1:exon

YKL060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LOT1
gene: FBA1
locus tag: YKL060C
gene synonym: LOT1
so part of: sequence
location: complement(<326408..>327487)
location: region:326408-327487:-1
so has part: feature:326408-327487:-1:exon
subclass of: SO_0000010

853805
type: Gene
SIO_000068: ncbigene

position:326408:-1
position: 326408
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:327487:-1
position: 327487
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326408-327487:-1:exon

YKL060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LOT1
gene: FBA1
locus tag: YKL060C
gene synonym: LOT1
product: fructose-bisphosphate aldolase FBA1
transcript id: NM_001179626.1
SIO_010081: YKL060C
subclass of: SO_0000673
so part of: YKL060C
location: complement(<326408..>327487)
location: region:326408-327487:-1
so has part: feature:326408-327487:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326408-327487:-1:exon

YKL060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LOT1
gene: FBA1
locus tag: YKL060C
gene synonym: LOT1
EC number: 4.1.2.13
experiment: EXISTENCE:direct assay:GO:0004332 fructose-bisphosphate aldolase activity [PMID:2647491]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052|PMID:16962558|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]
experiment: EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]
experiment: EXISTENCE:mutant phenotype:GO:0004332 fructose-bisphosphate aldolase activity [PMID:2647491]
experiment: EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:6384192]
experiment: EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:6384192]
note: Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo
codon start: 1
product: fructose-bisphosphate aldolase FBA1
translation: MGVEQILKRKTGVIVGEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISNEGQNASIKGAIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLEMEIGITGGEEDGVNNENADKEDLYTKPEQVYNVYKALHPISPNFSIAAAFGNCHGLYAGDIALRPEILAEHQKYTREQVGCKEEKPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSPVGNPEGPEKPNKKFFDPRVWVREGEKTMGAKITKSLETFRTTNTL
SIO_010081: YKL060C
subclass of: SO_0000673
so part of: YKL060C
location: complement(326408..327487)
location: region:326408-327487:-1
so has part: feature:326408-327487:-1:exon

NP_012863.1
type: Protein
SIO_000068: ncbiprotein

S000001543
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326408-327487:-1:exon

YKL059C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPE1
locus tag: YKL059C
so part of: sequence
location: complement(<328118..>329443)
location: region:328118-329443:-1
so has part: feature:328118-329443:-1:exon
subclass of: SO_0000010

853806
type: Gene
SIO_000068: ncbigene

position:328118:-1
position: 328118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:329443:-1
position: 329443
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328118-329443:-1:exon

YKL059C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPE1
locus tag: YKL059C
product: cleavage polyadenylation factor subunit MPE1
transcript id: NM_001179625.1
SIO_010081: YKL059C
subclass of: SO_0000673
so part of: YKL059C
location: complement(<328118..>329443)
location: region:328118-329443:-1
so has part: feature:328118-329443:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:328118-329443:-1:exon

YKL059C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPE1
locus tag: YKL059C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:35584695]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:35584695]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11713271|PMID:35584695]
experiment: EXISTENCE:direct assay:GO:0036002 pre-mRNA binding [PMID:25135474|PMID:35584695]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:35584695]
experiment: EXISTENCE:genetic interaction:GO:0016567 protein ubiquitination [PMID:25135474]
experiment: EXISTENCE:genetic interaction:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11713271]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:32009536]
experiment: EXISTENCE:mutant phenotype:GO:0006378 mRNA polyadenylation [PMID:11713271]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:25135474]
experiment: EXISTENCE:mutant phenotype:GO:0036002 pre-mRNA binding [PMID:25135474]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:32009536]
experiment: EXISTENCE:mutant phenotype:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11713271]
note: Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase; detects polyadenylation signal in nascent pre-mRNA and triggers 3' end formation of mRNA via cleavage and polyadenylation; binds pre-mRNA via zinc knuckle and RING finger; E3 ubiquitin ligase involved in polyubiquitination of endonuclease Ysh1p; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; relocalizes to cytosol in response to hypoxia; homolog of human RBBP6
codon start: 1
product: cleavage polyadenylation factor subunit MPE1
translation: MSSTIFYRFKSQRNTSRILFDGTGLTVFDLKREIIQENKLGDGTDFQLKIYNPDTEEEYDDDAFVIPRSTSVIVKRSPAIKSFSVHSRLKGNVGAAALGNATRYVTGRPRVLQKRQHTATTTANVSGTTEEERIASMFATQENQWEQTQEEMSAATPVFFKSQTNKNSAQENEGPPPPGYMCYRCGGRDHWIKNCPTNSDPNFEGKRIRRTTGIPKKFLKSIEIDPETMTPEEMAQRKIMITDEGKFVVQVEDKQSWEDYQRKRENRQIDGDETIWRKGHFKDLPDDLKCPLTGGLLRQPVKTSKCCNIDFSKEALENALVESDFVCPNCETRDILLDSLVPDQDKEKEVETFLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK
SIO_010081: YKL059C
subclass of: SO_0000673
so part of: YKL059C
location: complement(328118..329443)
location: region:328118-329443:-1
so has part: feature:328118-329443:-1:exon

NP_012864.1
type: Protein
SIO_000068: ncbiprotein

S000001542
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328118-329443:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1109; Autonomously Replicating Sequence
so part of: sequence
location: 329682..329930
location: region:329682-329930:1
so has part: feature:329682-329930:1:region

S000118403
type: SGD
SIO_000068: sgd

position:329682:1
position: 329682
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:329930:1
position: 329930
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:329682-329930:1:region

YKL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOA2
locus tag: YKL058W
so part of: sequence
location: <330166..>330534
location: region:330166-330534:1
so has part: feature:330166-330534:1:exon
subclass of: SO_0000010

853807
type: Gene
SIO_000068: ncbigene

position:330166:1
position: 330166
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330534:1
position: 330534
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330166-330534:1:exon

YKL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOA2
locus tag: YKL058W
product: transcription initiation factor IIA subunit gamma
transcript id: NM_001179624.1
SIO_010081: YKL058W
subclass of: SO_0000673
so part of: YKL058W
location: <330166..>330534
location: region:330166-330534:1
so has part: feature:330166-330534:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330166-330534:1:exon

YKL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOA2
locus tag: YKL058W
experiment: EXISTENCE:direct assay:GO:0005672 transcription factor TFIIA complex [PMID:7862117]
experiment: EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:7862117]
experiment: EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:7604282]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:15132995]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:15132995]
note: TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
codon start: 1
product: transcription initiation factor IIA subunit gamma
translation: MAVPGYYELYRRSTIGNSLVDALDTLISDGRIEASLAMRVLETFDKVVAETLKDNTQSKLTVKGNLDTYGFCDDVWTFIVKNCQVTVEDSHRDASQNGSGDSQSVISVDKLRIVACNSKKSE
SIO_010081: YKL058W
subclass of: SO_0000673
so part of: YKL058W
location: 330166..330534
location: region:330166-330534:1
so has part: feature:330166-330534:1:exon

NP_012865.1
type: Protein
SIO_000068: ncbiprotein

S000001541
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330166-330534:1:exon

YKL057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RAT2
gene: NUP120
locus tag: YKL057C
gene synonym: RAT2
so part of: sequence
location: complement(<330856..>333969)
location: region:330856-333969:-1
so has part: feature:330856-333969:-1:exon
subclass of: SO_0000010

853808
type: Gene
SIO_000068: ncbigene

position:330856:-1
position: 330856
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:333969:-1
position: 333969
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330856-333969:-1:exon

YKL057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RAT2
gene: NUP120
locus tag: YKL057C
gene synonym: RAT2
product: Nup120p
transcript id: NM_001179623.1
SIO_010081: YKL057C
subclass of: SO_0000673
so part of: YKL057C
location: complement(<330856..>333969)
location: region:330856-333969:-1
so has part: feature:330856-333969:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330856-333969:-1:exon

YKL057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RAT2
gene: NUP120
locus tag: YKL057C
gene synonym: RAT2
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]
experiment: EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22110603]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532|PMID:17538013]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8557736|PMID:8557737|PMID:8565072]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]
experiment: EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:8557736]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:22331846|PMID:8557736|PMID:8557737|PMID:8565072|PMID :9725905]
note: Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160
codon start: 1
product: Nup120p
translation: MACLSRIDANLLQYYEKPEPNNTVDLYVSNNSNNNGLKEGDKSISTPVPQPYGSEYSNCLLLSNSEYICYHFSSRSTLLTFYPLSDAYHGKTINIHLPNASMNQRYTLTIQEVEQQLLVNVILKDGSFLTLQLPLSFLFSSANTLNGEWFHLQNPYDFTVRVPHFLFYVSPQFSVVFLEDGGLLGLKKVDGVHYEPLLFNDNSYLKSLTRFFSRSSKSDYDSVISCKLFHERYLIVLTQNCHLKIWDLTSFTLIQDYDMVSQSDSDPSHFRKVEAVGEYLSLYNNTLVTLLPLENGLFQMGTLLVDSSGILTYTFQNNIPTNLSASAIWSIVDLVLTRPLELNVEASYLNLIVLWKSGTASKLQILNVNDESFKNYEWIESVNKSLVDLQSEHDLDIVTKTGDVERGFCNLKSRYGTQIFERAQQILSENKIIMAHNEDEEYLANLETILRDVKTAFNEASSITLYGDEIILVNCFQPYNHSLYKLNTTVENWFYNMHSETDGSELFKYLRTLNGFASTLSNDVLRSISKKFLDIITGELPDSMTTVEKFTDIFKNCLENQFEITNLKILFDELNSFDIPVVLNDLINNQMKPGIFWKKDFISAIKFDGFTSIISLESLHQLLSIHYRITLQVLLTFVLFDLDTEIFGQHISTLLDLHYKQFLLLNLYRQDKCLLAEVLLKDSSEFSFGVKFFNYGQLIAYIDSLNSNVYNASITENSFFMTFFRSYIIENTSHKNIRFFLENVECPFYLRHNEVQEFMFAMTLFSCGNFDQSYEIFQLHDYPEAINDKLPTFLEDLKSENYHGDSIWKDLLCTFTVPYRHSAFYYQLSLLFDRNNSQEFALKCISKSAEYSLKEIQIEELQDFKEKQHIHYLNLLIHFRMFEEVLDVLRLGHECLSDTVRTNFLQLLLQEDIYSRDFFSTLLRLCNAHSDNGELYLRTVDIKIVDSILSQNLRSGDWECFKKLYCFRMLNKSERAAAEVLYQYILMQADLDVIRKRKCYLMVINVLSSFDSAYDQWILNGSKVVTLTDLRDELRGL
SIO_010081: YKL057C
subclass of: SO_0000673
so part of: YKL057C
location: complement(330856..333969)
location: region:330856-333969:-1
so has part: feature:330856-333969:-1:exon

NP_012866.1
type: Protein
SIO_000068: ncbiprotein

S000001540
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330856-333969:-1:exon

YKL056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMI1
gene: TMA19
locus tag: YKL056C
gene synonym: MMI1
so part of: sequence
location: complement(<334412..>334915)
location: region:334412-334915:-1
so has part: feature:334412-334915:-1:exon
subclass of: SO_0000010

853809
type: Gene
SIO_000068: ncbigene

position:334412:-1
position: 334412
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334915:-1
position: 334915
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334412-334915:-1:exon

YKL056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMI1
gene: TMA19
locus tag: YKL056C
gene synonym: MMI1
product: Tma19p
transcript id: NM_001179622.1
SIO_010081: YKL056C
subclass of: SO_0000673
so part of: YKL056C
location: complement(<334412..>334915)
location: region:334412-334915:-1
so has part: feature:334412-334915:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334412-334915:-1:exon

YKL056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMI1
gene: TMA19
locus tag: YKL056C
gene synonym: MMI1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16702403]
experiment: EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:31936125]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:16806052]
note: Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1
codon start: 1
product: Tma19p
translation: MIIYKDIFSNDELLSDAYDAKLVDDVIYEADCAMVNVGGDNIDIGANPSAEGGDDDVEEGAEMVNNVVHSFRLQQTAFDKKSFLTYIKGYMKAVKAKLQETNPEEVPKFEKGAQTYVKKVIGSFKDWEFFTGESMDPDAMVVMLNYREDGTTPFVAIWKHGIVEEKI
SIO_010081: YKL056C
subclass of: SO_0000673
so part of: YKL056C
location: complement(334412..334915)
location: region:334412-334915:-1
so has part: feature:334412-334915:-1:exon

NP_012867.1
type: Protein
SIO_000068: ncbiprotein

S000001539
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334412-334915:-1:exon

YKL055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OAR1
locus tag: YKL055C
so part of: sequence
location: complement(<335321..>336157)
location: region:335321-336157:-1
so has part: feature:335321-336157:-1:exon
subclass of: SO_0000010

853810
type: Gene
SIO_000068: ncbigene

position:335321:-1
position: 335321
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:336157:-1
position: 336157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:335321-336157:-1:exon

YKL055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OAR1
locus tag: YKL055C
product: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
transcript id: NM_001179621.2
SIO_010081: YKL055C
subclass of: SO_0000673
so part of: YKL055C
location: complement(<335321..>336157)
location: region:335321-336157:-1
so has part: feature:335321-336157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:335321-336157:-1:exon

YKL055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OAR1
locus tag: YKL055C
EC number: 1.1.1.100
experiment: EXISTENCE:direct assay:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:19571038]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:9388293]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9388293]
experiment: EXISTENCE:mutant phenotype:GO:0006631 fatty acid metabolic process [PMID:9388293]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9388293]
note: Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant
codon start: 1
product: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)
translation: MHYLPVAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQSGLSYQRQCAIAIDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAGLTQESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSILHSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQNLPVEAKEMLERTIGASGTSAPAEIAEEVWSLYSRTALET
SIO_010081: YKL055C
subclass of: SO_0000673
so part of: YKL055C
location: complement(335321..336157)
location: region:335321-336157:-1
so has part: feature:335321-336157:-1:exon

NP_012868.1
type: Protein
SIO_000068: ncbiprotein

S000001538
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:335321-336157:-1:exon

YKL054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VID31
gene: DEF1
locus tag: YKL054C
gene synonym: VID31
so part of: sequence
location: complement(<336537..>338753)
location: region:336537-338753:-1
so has part: feature:336537-338753:-1:exon
subclass of: SO_0000010

853811
type: Gene
SIO_000068: ncbigene

position:336537:-1
position: 336537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:338753:-1
position: 338753
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:336537-338753:-1:exon

YKL054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VID31
gene: DEF1
locus tag: YKL054C
gene synonym: VID31
product: DNA damage-responsive RNA polymerase-degradation factor DEF1
transcript id: NM_001179620.1
SIO_010081: YKL054C
subclass of: SO_0000673
so part of: YKL054C
location: complement(<336537..>338753)
location: region:336537-338753:-1
so has part: feature:336537-338753:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:336537-338753:-1:exon

YKL054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VID31
gene: DEF1
locus tag: YKL054C
gene synonym: VID31
experiment: EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11859374]
experiment: EXISTENCE:direct assay:GO:0062058 transcription factor TFIIH holo complex binding [PMID:29180430]
experiment: EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:15863512]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:11859374]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11859374]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:11859374]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:24465179]
experiment: EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:29180430]
note: RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; interacts with general transcription factor TFIIH; mutant is deficient in Zip1p loading onto chromosomes during meiosis; null mutant is prone to self-diploidization; null mutation can be functionally complemented by human UBAP2 and UBAP2
codon start: 1
product: DNA damage-responsive RNA polymerase-degradation factor DEF1
translation: MSTQFRKSNHNSHSSKKLNPALKSKIDTLTELFPDWTSDDLIDIVQEYDDLETIIDKITSGAVTRWDEVKKPAKKEKYEKKEQQHSYVPQQHLPNPEDDITYKSSNNSNSFTSTKHNSSNNYTQARNKKKVQTPRAHTTGKHVNLDKGKHVPSKPVSNTTSWAAAVSVDTKHDVPQDSNDNNNEELEAQGQQAQEKNQEKEQEEQQQQEGHNNKEEHKQIEQPSLSSKKTTSRTSASQPKKMSWAAIATPKPKAVKKTESPLENVAELKKEISDIKKDDQKSEASEEKVNEQETSAQEQEEETAEPSEENEDRVPEVDGEEVQEEAEKKEQVKEEEQTAEELEQEQDNVAAPEEEVTVVEEKVEISAVISEPPEDQANTVPQPQQQSQQPQQPQQPQQPQQPQQPQQQQQPQQPQQPQQQLQQQQQQQQQPVQAQAQAQEEQLSQNYYTQQQQQQYAQQQHQLQQQYLSQQQQYAQQQQQHPQPQSQQPQSQQSPQSQKQGNNVAAQQYYMYQNQFPGYSYPGMFDSQGYAYGQQYQQLAQNNAQTSGNANQYNFQQGYGQAGANTAAANLTSAAAAAAASPATAHAQPQQQQPYGGSFMPYYAHFYQQSFPYGQPQYGVAGQYPYQLPKNNYNYYQTQNGQEQQSPNQGVAQHSEDSQQKQSQQQQQQQPQGQPQPEVQMQNGQPVNPQQQMQFQQYYQFQQQQQQAAAAAAAAAQQGVPYGYNGYDYNSKNSRGFY
SIO_010081: YKL054C
subclass of: SO_0000673
so part of: YKL054C
location: complement(336537..338753)
location: region:336537-338753:-1
so has part: feature:336537-338753:-1:exon

NP_012869.1
type: Protein
SIO_000068: ncbiprotein

S000001537
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:336537-338753:-1:exon

YKL053C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDM35
locus tag: YKL053C-A
so part of: sequence
location: complement(<339182..>339442)
location: region:339182-339442:-1
so has part: feature:339182-339442:-1:exon
subclass of: SO_0000010

853812
type: Gene
SIO_000068: ncbigene

position:339182:-1
position: 339182
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339442:-1
position: 339442
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339182-339442:-1:exon

YKL053C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDM35
locus tag: YKL053C-A
product: Mdm35p
transcript id: NM_001184336.1
SIO_010081: YKL053C-A
subclass of: SO_0000673
so part of: YKL053C-A
location: complement(<339182..>339442)
location: region:339182-339442:-1
so has part: feature:339182-339442:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339182-339442:-1:exon

YKL053C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDM35
locus tag: YKL053C-A
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]
experiment: EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:27354379]
experiment: EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:26235513]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]
experiment: EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]
note: Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
codon start: 1
product: Mdm35p
translation: MGNIMSASFAPECTDLKTKYDSCFNEWYSEKFLKGKSVENECSKQWYAYTTCVNAALVKQGIKPALDEAREEAPFENGGKLKEVDK
SIO_010081: YKL053C-A
subclass of: SO_0000673
so part of: YKL053C-A
location: complement(339182..339442)
location: region:339182-339442:-1
so has part: feature:339182-339442:-1:exon

NP_012870.1
type: Protein
SIO_000068: ncbiprotein

S000007243
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339182-339442:-1:exon

YKL052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ASK1
locus tag: YKL052C
so part of: sequence
location: complement(<339668..>340546)
location: region:339668-340546:-1
so has part: feature:339668-340546:-1:exon
subclass of: SO_0000010

853814
type: Gene
SIO_000068: ncbigene

position:339668:-1
position: 339668
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:340546:-1
position: 340546
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339668-340546:-1:exon

YKL052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ASK1
locus tag: YKL052C
product: Ask1p
transcript id: NM_001179618.1
SIO_010081: YKL052C
subclass of: SO_0000673
so part of: YKL052C
location: complement(<339668..>340546)
location: region:339668-340546:-1
so has part: feature:339668-340546:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339668-340546:-1:exon

YKL052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ASK1
locus tag: YKL052C
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress
codon start: 1
product: Ask1p
translation: MDSASKEETLEKLDQEITVNLQKIDSNLSFCFHKITQDIIPHVATYSEICERIMDSTEWLGTMFQETGLVNLQANAAAPVGNAPVKSLVSNNVGIFPTSAEEASRQSQTDNGPNEADSAVHVNRDVHSMFNNDSIDDFHTANITSTGQILKLPDSSDEDTGSEAVPSREQTDLTGEGHGGADDEQDESTIQRQSRKRKISLLLQQQYGSSSSMVPSPIVPNKMRKQLAHEEHINNDGDNDDENSNNIESSPLKQGHHHPKGQADDNNEGPDEEESTKEVPKPGTIIHFSTNR
SIO_010081: YKL052C
subclass of: SO_0000673
so part of: YKL052C
location: complement(339668..340546)
location: region:339668-340546:-1
so has part: feature:339668-340546:-1:exon

NP_012872.2
type: Protein
SIO_000068: ncbiprotein

S000001535
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339668-340546:-1:exon

YKL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SFK1
locus tag: YKL051W
so part of: sequence
location: <341312..>342373
location: region:341312-342373:1
so has part: feature:341312-342373:1:exon
subclass of: SO_0000010

853815
type: Gene
SIO_000068: ncbigene

position:341312:1
position: 341312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:342373:1
position: 342373
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341312-342373:1:exon

YKL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SFK1
locus tag: YKL051W
product: Sfk1p
transcript id: NM_001179617.1
SIO_010081: YKL051W
subclass of: SO_0000673
so part of: YKL051W
location: <341312..>342373
location: region:341312-342373:1
so has part: feature:341312-342373:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341312-342373:1:exon

YKL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SFK1
locus tag: YKL051W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12015967]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0007033 vacuole organization [PMID:12015967]
experiment: EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:12015967]
experiment: EXISTENCE:genetic interaction:GO:0048017 inositol lipid-mediated signaling [PMID:12015967]
experiment: EXISTENCE:genetic interaction:GO:0061093 negative regulation of phospholipid translocation [PMID:29540528]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12015967]
experiment: EXISTENCE:mutant phenotype:GO:0061093 negative regulation of phospholipid translocation [PMID:29540528]
note: Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane
codon start: 1
product: Sfk1p
translation: MIQFKSPGNWLFIVPWIAFIPWYGMLIAMLICWASQGHPIYWFMHSEQFPVYISDIGATNLRPLFISCAGWQGLGYVITVALEFFQRSGYLPFQLKKKDPSISDSTSYAEKLHSGKYLMPPYYTKDERNLIFAAFVLGSIGELALLFSSIFSTALYHRVHIAMVSVFVVFMFLSTCCLIAEYFLMGRHYASVHPLASPHFNPQSSEKSFNQDYNTVDELPWYKWKGHVWNKFTISATLKVIWLTLAVVWAICFGAINDRSKSACFEWLLAFWFGIIFMILSADFYLGGRYRQSRYFNHVESFSGYYKYDKALGLYHSEDVLPSDDNAGVIATETASSNIYNNSSSNESIQVVV
SIO_010081: YKL051W
subclass of: SO_0000673
so part of: YKL051W
location: 341312..342373
location: region:341312-342373:1
so has part: feature:341312-342373:1:exon

NP_012873.1
type: Protein
SIO_000068: ncbiprotein

S000001534
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341312-342373:1:exon

YKL050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LPX2
locus tag: YKL050C
so part of: sequence
location: complement(<342852..>345620)
location: region:342852-345620:-1
so has part: feature:342852-345620:-1:exon
subclass of: SO_0000010

853816
type: Gene
SIO_000068: ncbigene

position:342852:-1
position: 342852
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345620:-1
position: 345620
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342852-345620:-1:exon

YKL050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LPX2
locus tag: YKL050C
product: Lpx2p
transcript id: NM_001179616.1
SIO_010081: YKL050C
subclass of: SO_0000673
so part of: YKL050C
location: complement(<342852..>345620)
location: region:342852-345620:-1
so has part: feature:342852-345620:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342852-345620:-1:exon

YKL050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LPX2
locus tag: YKL050C
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: Peroxisomal matrix-localized lipase; target of SCFCdc4 ubiquitin ligase complex; peroxisomal, nuclear and cytosolic localization is dependent on the presence of oleate; transcription is regulated by Azf1p; LPX2 has a paralog, EIS1, that arose from the whole genome duplication
codon start: 1
product: Lpx2p
translation: MSLISALQTTDVESVQTSPEQITERKAVRVSTLQESLHSSEMHRAAPETPRSISNSVHKLKTIYSTYQQSGQPLSKEAIFRAKQKYGILNTPANYKTLGLGDSKSESVDLAARLASKRTKVSPDDCVETAIEQKARGEAFKVTFSKIPLTPPEDVPITVNLGLKGRRDFLTRLAAQKALAFSPSLDNSMKGTSDSSSVKKKRFSGAPIGNEFDANLVNPQHPAGFKSLDLSKVLDGAERRAISRVNDRLYPQKVNFKNGLQSSDQSGVSKANKEVFKKGTLEKLEHSAEQFLESHAGNERQRLSDQQYMCAKGAADAVKDLDPKTLEDPDFAAREAQKKLYIKQVASPVVLNEAQKLANRKLQDIDSRDTYMLLFGNQAYNKLAVNIALQHYSVKQEEKKKIYLGGGLWMTPEEVNAVAKKLISPVVNEIDERASRQRDVDKDIERRSRVLDQEYEDGNSMERAKEQNDGQLLLAMASKQQQEKEAKKAEEGQRYDQFVQKMNIKLQQKEKELENARENRENLRNELQERLSKNLSGENDELNDWNDACERDLKNSSIEHYYAVRSHFDNLGNSERGYDELLEERSKIQVEIERLVASIAEHKTAIHGFGETADAGGAIPAVQKQKIPTRKDLLDATVNDPLVISAEMAKEEAEMATEECMLKELQVDEMIIIRNIMLRECEKKLEEEKETAKRSRRGTEESKNNSNFSRDVIMSTPDNNEKVTPIGKSASPKDVVKSRFLSTYNTGKDIDSSASARSITGVSGVLDDGPKTPTSNKENELIDDEVKSYKVHQAVDGTGEDSIANKRDKSSRPAANSGGSITIEQFLFNKNADKQGLSKTESVTMKREPVVDQMDSKKGHDFTHCNDNGRRSFSGFSQGSIENDYSNEVTDDQDDQEGSEIRVRDSNDSNTSPKESFFKEVI
SIO_010081: YKL050C
subclass of: SO_0000673
so part of: YKL050C
location: complement(342852..345620)
location: region:342852-345620:-1
so has part: feature:342852-345620:-1:exon

NP_012874.1
type: Protein
SIO_000068: ncbiprotein

S000001533
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342852-345620:-1:exon

YKL049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSL2
gene: CSE4
locus tag: YKL049C
gene synonym: CSL2
so part of: sequence
location: complement(<346075..>346764)
location: region:346075-346764:-1
so has part: feature:346075-346764:-1:exon
subclass of: SO_0000010

853817
type: Gene
SIO_000068: ncbigene

position:346075:-1
position: 346075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346764:-1
position: 346764
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346075-346764:-1:exon

YKL049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSL2
gene: CSE4
locus tag: YKL049C
gene synonym: CSL2
product: centromeric DNA-binding histone H3-like protein CSE4
transcript id: NM_001179615.1
SIO_010081: YKL049C
subclass of: SO_0000673
so part of: YKL049C
location: complement(<346075..>346764)
location: region:346075-346764:-1
so has part: feature:346075-346764:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346075-346764:-1:exon

YKL049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSL2
gene: CSE4
locus tag: YKL049C
gene synonym: CSL2
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16207811|PMID:23623551]
experiment: EXISTENCE:direct assay:GO:0005729 2-micrometer circle DNA [PMID:16966420]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:11063678|PMID:23623551]
experiment: EXISTENCE:direct assay:GO:0043505 CENP-A containing nucleosome [PMID:11063678|PMID:19782029]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:16966420]
experiment: EXISTENCE:genetic interaction:GO:0000779 condensed chromosome, centromeric region [PMID:11063678]
experiment: EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:7698647]
experiment: EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:16966420]
experiment: EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:16207811]
experiment: EXISTENCE:mutant phenotype:GO:0061644 protein localization to CENP-A containing chromatin [PMID:28980861]
note: Centromeric histone H3-like protein; associates with promoters, accessible chromatin, and RNAPII-bound regions; Cse4p associates with centromeres, promoting kinetochore assembly and Sgo1p association with centromeric chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting bi-orientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes faithful chromosome segregation; regulated by multiple E3 ligases; complements human homolog CENPA mutations
codon start: 1
product: centromeric DNA-binding histone H3-like protein CSE4
translation: MSSKQQWVSSAIQSDSSGRSLSNVNRLAGDQQSINDRALSLLQRTRATKNLFPRREERRRYESSKSDLDIETDYEDQAGNLEIETENEEEAEMETEVPAPVRTHSYALDRYVRQKRREKQRKQSLKRVEKKYTPSELALYEIRKYQRSTDLLISKIPFARLVKEVTDEFTTKDQDLRWQSMAIMALQEASEAYLVGLLEHTNLLALHAKRITIMKKDMQLARRIRGQFI
SIO_010081: YKL049C
subclass of: SO_0000673
so part of: YKL049C
location: complement(346075..346764)
location: region:346075-346764:-1
so has part: feature:346075-346764:-1:exon

NP_012875.2
type: Protein
SIO_000068: ncbiprotein

S000001532
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346075-346764:-1:exon

YKL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LDB9
gene: ELM1
locus tag: YKL048C
gene synonym: LDB9
so part of: sequence
location: complement(<347214..>349136)
location: region:347214-349136:-1
so has part: feature:347214-349136:-1:exon
subclass of: SO_0000010

853818
type: Gene
SIO_000068: ncbigene

position:347214:-1
position: 347214
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349136:-1
position: 349136
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347214-349136:-1:exon

YKL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LDB9
gene: ELM1
locus tag: YKL048C
gene synonym: LDB9
product: serine/threonine protein kinase ELM1
transcript id: NM_001179614.1
SIO_010081: YKL048C
subclass of: SO_0000673
so part of: YKL048C
location: complement(<347214..>349136)
location: region:347214-349136:-1
so has part: feature:347214-349136:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:347214-349136:-1:exon

YKL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LDB9
gene: ELM1
locus tag: YKL048C
gene synonym: LDB9
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:27053666]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:12847291|PMID:16201971|PMID:9180279]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000023 maltose metabolic process [PMID:34140941]
experiment: EXISTENCE:mutant phenotype:GO:0000144 cellular bud neck septin ring [PMID:27053666]
experiment: EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:10725226]
experiment: EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:16607009|PMID:9427410]
experiment: EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:10725226]
experiment: EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:10234786]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9891070]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:15340085]
experiment: EXISTENCE:mutant phenotype:GO:1902935 protein localization to septin ring [PMID:27053666]
note: Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis
codon start: 1
product: serine/threonine protein kinase ELM1
translation: MSPRQLIPTLIPEWAPLSQQSCIREDELDSPPITPTSQTSSFGSSFSQQKPTYSTIIGENIHTILDEIRPYVKKITVSDQDKKTINQYTLGVSAGSGQFGYVRKAYSSTLGKVVAVKIIPKKPWNAQQYSVNQVMRQIQLWKSKGKITTNMSGNEAMRLMNIEKCRWEIFAASRLRNNVHIVRLIECLDSPFSESIWIVTNWCSLGELQWKRDDDEDILPQWKKIVISNCSVSTFAKKILEDMTKGLEYLHSQGCIHRDIKPSNILLDEEEKVAKLSDFGSCIFTPQSLPFSDANFEDCFQRELNKIVGTPAFIAPELCHLGNSKRDFVTDGFKLDIWSLGVTLYCLLYNELPFFGENEFETYHKIIEVSLSSKINGNTLNDLVIKRLLEKDVTLRISIQDLVKVLSRDQPIDSRNHSQISSSSVNPVRNEGPVRRFFGRLLTKKGKKKTSGKGKDKVLVSATSKVTPSIHIDEEPDKECFSTTVLRSSPDSSDYCSSLGEEAIQVTDFLDTFCRSNESLPNLTVNNDKQNSDMKTDRSESSSHSSLKIPTPIKAMIRLKSSPKENGNRTHINCSQDKPSSPLMDRTVGKRTVNNSGARKLAHSSNILNFKAYINSEDSDIRETVEDVKTYLNFADNGQI
SIO_010081: YKL048C
subclass of: SO_0000673
so part of: YKL048C
location: complement(347214..349136)
location: region:347214-349136:-1
so has part: feature:347214-349136:-1:exon

NP_012876.1
type: Protein
SIO_000068: ncbiprotein

S000001531
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:347214-349136:-1:exon

YKL047W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ANR2
locus tag: YKL047W
so part of: sequence
location: <349463..>351013
location: region:349463-351013:1
so has part: feature:349463-351013:1:exon
subclass of: SO_0000010

853819
type: Gene
SIO_000068: ncbigene

position:349463:1
position: 349463
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351013:1
position: 351013
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349463-351013:1:exon

YKL047W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ANR2
locus tag: YKL047W
product: Anr2p
transcript id: NM_001179613.1
SIO_010081: YKL047W
subclass of: SO_0000673
so part of: YKL047W
location: <349463..>351013
location: region:349463-351013:1
so has part: feature:349463-351013:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349463-351013:1:exon

YKL047W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ANR2
locus tag: YKL047W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]
note: hypothetical protein; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated
codon start: 1
product: Anr2p
translation: MNSGGEEPTIKPNVFNITQLLNSNGEKPGIACIFLSKFDMKKGNIIIWSKSINGAAIDLSNIEFKSLPAGIHEQTDDVVNFVVPKELDVCQTAKTTTYDYGIAYFKQNSFDIIENDNRIDRSKVQMFSLGVIIDVQNASSDSKKHFYKEIYHAYAANRYSSYLESLLGQWIRQRDLDKFDIFEKFFDENNQGHMAENSVEVFEHSPKERRHLVEYLPYWTRKLGPLIFPLWKASLLQSRILILVPQGESFELCNSLAYCVFLISMLPKNLIGNHVSDEYIKPIFTVSTSDIPFLESFKKGNGYVATTSEEILLYKPEIYDIVVKLTSSSTIEESPEKEVEILTASGEQNKATPLDLEVYEKLILGELQEDASTNATCRHHEVTEPISWLQFLIDGFFLLTTAGYLVAPYHLANNFKIPRHVSGPEPNNSEIQIAENLVRYFHRRTSNLYNDLKDVIQKSENIDSEQPITIAASFLTKLNLDCFSKQDHQFVKDIALKWFQRSIDISNLPECLGNLC
SIO_010081: YKL047W
subclass of: SO_0000673
so part of: YKL047W
location: 349463..351013
location: region:349463-351013:1
so has part: feature:349463-351013:1:exon

NP_012877.1
type: Protein
SIO_000068: ncbiprotein

S000001530
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349463-351013:1:exon

YKL046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DCW1
locus tag: YKL046C
so part of: sequence
location: complement(<351275..>352624)
location: region:351275-352624:-1
so has part: feature:351275-352624:-1:exon
subclass of: SO_0000010

853820
type: Gene
SIO_000068: ncbigene

position:351275:-1
position: 351275
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352624:-1
position: 352624
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:351275-352624:-1:exon

YKL046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DCW1
locus tag: YKL046C
product: putative mannan endo-1,6-alpha-mannosidase
transcript id: NM_001179612.1
SIO_010081: YKL046C
subclass of: SO_0000673
so part of: YKL046C
location: complement(<351275..>352624)
location: region:351275-352624:-1
so has part: feature:351275-352624:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:351275-352624:-1:exon

YKL046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DCW1
locus tag: YKL046C
EC number: 3.2.1.101
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12421307]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009272 fungal-type cell wall biogenesis [PMID:12421307]
experiment: EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:15470258]
note: Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
codon start: 1
product: putative mannan endo-1,6-alpha-mannosidase
translation: MLVNKVIGLLGVLFATRFTNAVELDLDNYESLQNATSLIAYGLMDYYTGNQYGKTVGMFSDPYYWWEAGGAWGCMLDYWFFMDNDTYNDEIIAAMIHQAGDDNDYIPLNQSTTEGNDDQAFWGIAAMTAAERNFTNPPENEPQWLYLAQAVFNTMALRWDADSCGGGLRWQIFVWNSGYDYKNTVSNGALFHIAARLARYTGNQTYVDWAEKVYEWMVGVNLISNGTYKYVYDGVSIDDNCTKVTSYQWTYNQGLLLAGSAYLYNFTGSDLWHTRTKEFLNASQVFFHDGIVYEAACQGPNSCNTDQRSFKAYFARFLGVTAQLVPETRNQIMSWLNTSAIAAAKSCSGGTDGHTCGLNWFNGTWDGMYGLGEQMSALEVMVNTRALDKPAPYTAENGGSSVGDGAAGTQAQPTNLAPLNITKGSKAGAGIITAVIGISIVACALWLVF
SIO_010081: YKL046C
subclass of: SO_0000673
so part of: YKL046C
location: complement(351275..352624)
location: region:351275-352624:-1
so has part: feature:351275-352624:-1:exon

NP_012878.1
type: Protein
SIO_000068: ncbiprotein

S000001529
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:351275-352624:-1:exon

YKL045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRI2
locus tag: YKL045W
so part of: sequence
location: <353493..>355079
location: region:353493-355079:1
so has part: feature:353493-355079:1:exon
subclass of: SO_0000010

853821
type: Gene
SIO_000068: ncbigene

position:353493:1
position: 353493
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:355079:1
position: 355079
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353493-355079:1:exon

YKL045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRI2
locus tag: YKL045W
product: DNA primase subunit PRI2
transcript id: NM_001179611.1
SIO_010081: YKL045W
subclass of: SO_0000673
so part of: YKL045W
location: <353493..>355079
location: region:353493-355079:1
so has part: feature:353493-355079:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:353493-355079:1:exon

YKL045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRI2
locus tag: YKL045W
experiment: EXISTENCE:curator inference:GO:0006270 DNA replication initiation [PMID:3888995]
experiment: EXISTENCE:curator inference:GO:0006273 lagging strand elongation [PMID:3888995]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:20404922]
experiment: EXISTENCE:direct assay:GO:0003896 DNA primase activity [PMID:3061469|PMID:3888995]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15282802]
experiment: EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]
experiment: EXISTENCE:direct assay:GO:0006269 DNA replication, synthesis of RNA primer [PMID:2644256]
experiment: EXISTENCE:genetic interaction:GO:0003896 DNA primase activity [PMID:8436268]
experiment: EXISTENCE:mutant phenotype:GO:0003896 DNA primase activity [PMID:8436268]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2023935]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]
note: Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair
codon start: 1
product: DNA primase subunit PRI2
translation: MFRQSKRRIASRKNFSSYDDIVKSELDVGNTNAANQIILSSSSSEEEKKLYARLYESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIESCLSRNKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRSKELREKFVRAETFLFKIRFNMLTSTDQTKFVQSLDLPLLQFISNEEKAELSHQLYQTVSASLQFQLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDGYAYLPQFQQLNLLSNEFASKLNQELIKTYQYLPRLNEDDRLLPILNHLSSGYTIADFNQQKANQFSENVDDEINAQSVWSEEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIGLSADEALKFWSEAFTRNGNMTMEKFNKEYRYSFRHNYGLEGNRINYKPWDCHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYTIACTKVFEMTHNSASADLEIGEQTHIAHPNLYFERSRQLQKKQQKLEKEKLFNNGNH
SIO_010081: YKL045W
subclass of: SO_0000673
so part of: YKL045W
location: 353493..355079
location: region:353493-355079:1
so has part: feature:353493-355079:1:exon

NP_012879.1
type: Protein
SIO_000068: ncbiprotein

S000001528
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:353493-355079:1:exon

YKL044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MMO1
locus tag: YKL044W
so part of: sequence
location: <356322..>356642
location: region:356322-356642:1
so has part: feature:356322-356642:1:exon
subclass of: SO_0000010

853822
type: Gene
SIO_000068: ncbigene

position:356322:1
position: 356322
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356642:1
position: 356642
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:356322-356642:1:exon

YKL044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MMO1
locus tag: YKL044W
product: Mmo1p
transcript id: NM_001270755.1
SIO_010081: YKL044W
subclass of: SO_0000673
so part of: YKL044W
location: <356322..>356642
location: region:356322-356642:1
so has part: feature:356322-356642:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:356322-356642:1:exon

YKL044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MMO1
locus tag: YKL044W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
note: hypothetical protein; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene
codon start: 1
product: Mmo1p
translation: MGYVIMTFSSARMSERRARIIYIWMHLSAYKINFPFVQFPTFFSLFRLQKKAAILIKNPSPFFLFFLFPYRKNSTARTIHQINQAVALVLLCVSHHLTYLPSVPSL
SIO_010081: YKL044W
subclass of: SO_0000673
so part of: YKL044W
location: 356322..356642
location: region:356322-356642:1
so has part: feature:356322-356642:1:exon

NP_001257684.1
type: Protein
SIO_000068: ncbiprotein

S000001527
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:356322-356642:1:exon

YKL043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHD1
locus tag: YKL043W
so part of: sequence
location: <356748..>357848
location: region:356748-357848:1
so has part: feature:356748-357848:1:exon
subclass of: SO_0000010

853823
type: Gene
SIO_000068: ncbigene

position:356748:1
position: 356748
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:357848:1
position: 357848
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:356748-357848:1:exon

YKL043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHD1
locus tag: YKL043W
product: Phd1p
transcript id: NM_001179609.1
SIO_010081: YKL043W
subclass of: SO_0000673
so part of: YKL043W
location: <356748..>357848
location: region:356748-357848:1
so has part: feature:356748-357848:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:356748-357848:1:exon

YKL043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHD1
locus tag: YKL043W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8114741]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16449570]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8114741]
experiment: EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:8114741]
note: Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
codon start: 1
product: Phd1p
translation: MYHVPEMRLHYPLVNTQSNAAITPTRSYDNTLPSFNELSHQSTINLPFVQRETPNAYANVAQLATSPTQAKSGYYCRYYAVPFPTYPQQPQSPYQQAVLPYATIPNSNFQPSSFPVMAVMPPEVQFDGSFLNTLHPHTELPPIIQNTNDTSVARPNNLKSIAAASPTVTATTRTPGVSSTSVLKPRVITTMWEDENTICYQVEANGISVVRRADNNMINGTKLLNVTKMTRGRRDGILRSEKVREVVKIGSMHLKGVWIPFERAYILAQREQILDHLYPLFVKDIESIVDARKPSNKASLTPKSSPAPIKQEPSDNKHEIATEIKPKSIDALSNGASTQGAGELPHLKINHIDTEAQTSRAKNELS
SIO_010081: YKL043W
subclass of: SO_0000673
so part of: YKL043W
location: 356748..357848
location: region:356748-357848:1
so has part: feature:356748-357848:1:exon

NP_012881.1
type: Protein
SIO_000068: ncbiprotein

S000001526
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:356748-357848:1:exon

YKL042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC42
locus tag: YKL042W
so part of: sequence
location: <358475..>359566
location: region:358475-359566:1
so has part: feature:358475-359566:1:exon
subclass of: SO_0000010

853824
type: Gene
SIO_000068: ncbigene

position:358475:1
position: 358475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:359566:1
position: 359566
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358475-359566:1:exon

YKL042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC42
locus tag: YKL042W
product: Spc42p
transcript id: NM_001179608.3
SIO_010081: YKL042W
subclass of: SO_0000673
so part of: YKL042W
location: <358475..>359566
location: region:358475-359566:1
so has part: feature:358475-359566:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:358475-359566:1:exon

YKL042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC42
locus tag: YKL042W
experiment: EXISTENCE:direct assay:GO:0005821 intermediate layer of spindle pole body [PMID:9215630]
experiment: EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:9215630]
experiment: EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:9215630]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:9153752]
note: Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
codon start: 1
product: Spc42p
translation: MNGSPTPKRYSSKSSRLYDDYYNIPYQYSNPTPMNRDYNDVGSRINADKLVPEEYKRNTEFINKAVQQNKELNFKLREKQNEIFELKKIAETLRSKLEKYVDITKKLEDQNLNLQIKISDLEKKLSDANSTFKEMRFPKVKDPMVDDDPVSENYDQINVPKHRAPDATGNPRTTNKVSNTSDQDSRLKAIERTLSVLTNYVMRSEDGNNDRMSPLPSPLNTILPINNRLNFQEPKRYNPTVKVNPSDDDIMMYESAELKRVEEEIEELKRKILVRKKHDLRKLSLNNQLQELQSMMDGDDNIKLDNVSKHNHATHRHSSQSSRDYSPSSDACLECSNDLYEKNRVKPENNMSETFATPTPNNR
SIO_010081: YKL042W
subclass of: SO_0000673
so part of: YKL042W
location: 358475..359566
location: region:358475-359566:1
so has part: feature:358475-359566:1:exon

NP_012882.3
type: Protein
SIO_000068: ncbiprotein

S000001525
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:358475-359566:1:exon

YKL041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DID3
alternative label: VPL26
gene: VPS24
locus tag: YKL041W
gene synonym: DID3; VPL26
so part of: sequence
location: <360143..>360817
location: region:360143-360817:1
so has part: feature:360143-360817:1:exon
subclass of: SO_0000010

853825
type: Gene
SIO_000068: ncbigene

position:360143:1
position: 360143
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360817:1
position: 360817
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360143-360817:1:exon

YKL041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DID3
alternative label: VPL26
gene: VPS24
locus tag: YKL041W
gene synonym: DID3; VPL26
product: ESCRT-III subunit protein VPS24
transcript id: NM_001179607.1
SIO_010081: YKL041W
subclass of: SO_0000673
so part of: YKL041W
location: <360143..>360817
location: region:360143-360817:1
so has part: feature:360143-360817:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360143-360817:1:exon

YKL041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DID3
alternative label: VPL26
gene: VPS24
locus tag: YKL041W
gene synonym: DID3; VPL26
experiment: EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9606181]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9606181]
experiment: EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
note: One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
codon start: 1
product: ESCRT-III subunit protein VPS24
translation: MDYIKKAIWGPDPKEQQRRIRSVLRKNGRNIEKSLRELTVLQNKTQQLIKKSAKKNDVRTVRLYAKELYQINKQYDRMYTSRAQLDSVRMKIDEAIRMNTLSNQMADSAGLMREVNSLVRLPQLRNTMIELEKELMKSGIISEMVDDTMESVGDVGEEMDEAVDEEVNKIVEQYTNEKFKNVDQVPTVELAANEEEQEIPDEKVDEEADRMVNEMRERLRALQN
SIO_010081: YKL041W
subclass of: SO_0000673
so part of: YKL041W
location: 360143..360817
location: region:360143-360817:1
so has part: feature:360143-360817:1:exon

NP_012883.1
type: Protein
SIO_000068: ncbiprotein

S000001524
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360143-360817:1:exon

YKL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NUB1
gene: NFU1
locus tag: YKL040C
gene synonym: NUB1
so part of: sequence
location: complement(<361058..>361828)
location: region:361058-361828:-1
so has part: feature:361058-361828:-1:exon
subclass of: SO_0000010

853826
type: Gene
SIO_000068: ncbigene

position:361058:-1
position: 361058
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361828:-1
position: 361828
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:361058-361828:-1:exon

YKL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NUB1
gene: NFU1
locus tag: YKL040C
gene synonym: NUB1
product: Nfu1p
transcript id: NM_001179606.3
SIO_010081: YKL040C
subclass of: SO_0000673
so part of: YKL040C
location: complement(<361058..>361828)
location: region:361058-361828:-1
so has part: feature:361058-361828:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:361058-361828:-1:exon

YKL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NUB1
gene: NFU1
locus tag: YKL040C
gene synonym: NUB1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10468587]
experiment: EXISTENCE:genetic interaction:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:27532773]
experiment: EXISTENCE:mutant phenotype:GO:0006880 intracellular sequestering of iron ion [PMID:10588895]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10468587|PMID:10588895]
experiment: EXISTENCE:mutant phenotype:GO:0097428 protein maturation by iron-sulfur cluster transfer [PMID:12065597]
experiment: EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:27532773]
experiment: EXISTENCE:physical interaction:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:27532773]
note: Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)
codon start: 1
product: Nfu1p
translation: MFKSVAKLGKSPIFYLNSQRLIHIKTLTTPNENALKFLSTDGEMLQTRGSKSIVIKNTDENLINHSKLAQQIFLQCPGVESLMIGDDFLTINKDRMVHWNSIKPEIIDLLTKQLAYGEDVISKEFHAVQEEEGEGGYKINMPKFELTEEDEEVSELIEELIDTRIRPAILEDGGDIDYRGWDPKTGTVYLRLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQIMDPEQEIALKEFDKLEKKLESSKNTSHEK
SIO_010081: YKL040C
subclass of: SO_0000673
so part of: YKL040C
location: complement(361058..361828)
location: region:361058-361828:-1
so has part: feature:361058-361828:-1:exon

NP_012884.3
type: Protein
SIO_000068: ncbiprotein

S000001523
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:361058-361828:-1:exon

YKL039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTM1
locus tag: YKL039W
so part of: sequence
location: <362622..>364193
location: region:362622-364193:1
so has part: feature:362622-364193:1:exon
subclass of: SO_0000010

853827
type: Gene
SIO_000068: ncbigene

position:362622:1
position: 362622
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:364193:1
position: 364193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362622-364193:1:exon

YKL039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTM1
locus tag: YKL039W
product: Ptm1p
transcript id: NM_001179605.1
SIO_010081: YKL039W
subclass of: SO_0000673
so part of: YKL039W
location: <362622..>364193
location: region:362622-364193:1
so has part: feature:362622-364193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:362622-364193:1:exon

YKL039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTM1
locus tag: YKL039W
note: hypothetical protein; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication
codon start: 1
product: Ptm1p
translation: MRVYQFCRPFQLFTCFLCYLLVFVKANKEKISQKNYQVCAGMYSKEDWKGKIDPFISFNLKKISGLSDESDPGLVVAIYDFQDFEHLGVQLPDEEMYYICDDYAIDIGICEEENRDEFIVQDVVYDPYTSTNRSLANPIMTFSQNEVGLHDTRYPIKETGFYCVTAFRSSTSTKFNAVVNFRNAYGQLAGTEINKLPLYGLLAVAYVVAMALYSFAFWKHKHELLPLQKYLLAFFVFLTAETIFVWAYYDLKNEKGDTAGIKVYMVFLSILTAGKVTFSFFLLLIIALGYGIVYPKLNKTLMRRCQMYGALTYAICIGFLIQSYLTDMEAPSPLILITLIPMALALIIFYYMIIRSMTKTVIYLKEQRQIVKLNMYKKLLYIIYASFLSVLAGSIVSSFIYVGMNTIDMIEKNWRSRFFVTDFWPTLVYFIVFVTIAFLWRPTDTSYMLAASQQLPTDPENVADFDLGDLQSFDDQDDASIITGERGIDEDDLNLNFTDDEEGHDNVNNHSQGHGPVSPSPTK
SIO_010081: YKL039W
subclass of: SO_0000673
so part of: YKL039W
location: 362622..364193
location: region:362622-364193:1
so has part: feature:362622-364193:1:exon

NP_012885.2
type: Protein
SIO_000068: ncbiprotein

S000001522
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:362622-364193:1:exon

YNCK0013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR69
locus tag: YNCK0013W
so part of: sequence
location: 364776..364876
location: region:364776-364876:1
so has part: feature:364776-364876:1:exon
subclass of: SO_0000578

9164914
type: Gene
SIO_000068: ncbigene

position:364776:1
position: 364776
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:364876:1
position: 364876
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364776-364876:1:exon

YNCK0013W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR69
locus tag: YNCK0013W
product: SNR69
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position C2948
transcript id: NR_132201.1
SIO_010081: YNCK0013W
subclass of: SO_0000673
so part of: YNCK0013W
location: 364776..364876
location: region:364776-364876:1
so has part: feature:364776-364876:1:exon

S000006460
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:364776-364876:1:exon

YKL038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RGT1
locus tag: YKL038W
so part of: sequence
location: <365605..>369117
location: region:365605-369117:1
so has part: feature:365605-369117:1:exon
subclass of: SO_0000010

853828
type: Gene
SIO_000068: ncbigene

position:365605:1
position: 365605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:369117:1
position: 369117
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:365605-369117:1:exon

YKL038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RGT1
locus tag: YKL038W
product: Rgt1p
transcript id: NM_001179604.3
SIO_010081: YKL038W
subclass of: SO_0000673
so part of: YKL038W
location: <365605..>369117
location: region:365605-369117:1
so has part: feature:365605-369117:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:365605-369117:1:exon

YKL038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RGT1
locus tag: YKL038W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10087931]
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12861007]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12861007|PMID:8887670|PMID:12239282]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8887670]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12861007]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12861007]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8887670]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8887670]
experiment: EXISTENCE:genetic interaction:GO:0006006 glucose metabolic process [PMID:8013905]
note: Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
codon start: 1
product: Rgt1p
translation: MNELNTVSTNSSDSTKNGGTSNSPDDMDSAAAASHAIKKRTKASRACDQCRKKKIKCDYKDEKGVCSNCQRNGDRCSFDRVPLKRGPSKGYTRSTSHPRTNEIQDHNNSRSYNTFDNSNNTLNNNTGNSGDNGINSNTVPSTPSRSNSVLLPPLTQYIPQAGGIPPSFQNPAIQSTMPAGNIGQQQFWKVPYHEFQHQRKGSIDSLQSDISVRTLNPNEQLSYNTVQQSPITNKHTNDSGNANGSVTGSGSASGSGGYWSFIRTSGLLAPTDDHNGEQTRRSSSIPSLLRNTSNSLLLGGQPQLPPPQQQSQPQAHQQKLQQGQNLYSYSQFSQQQPYNPSISSFGQFAANGFHSRQGSVASEAMSPSAPAMFTSTSTNPVNVAQQTQRPQGQQVPQFSSELDGNKRRQSAPVSVTLSTDRLNGNENNNGEINNNNGSNNSGSSKDTSQHSQESVTTPAALEASSPGSTPQRSTKKRRKSYVSKKTKPKRDSSISITSKDSAHPMTTSSTIAYGQISDVDLIDTYYEFIHVGFPIIPLNKTTLTSDLLLVNTQPISNIHEVNSYVILWFRNSLELLVRVALKQKPGGKFFDNIVGVALSPSNDNNKAGFTTATARDDAEKTRRDSHNEVQDTLEVQSVFIAALNECFQKIVDIHPKFRENNDQISPKIKVIYLSTFILLNYILAFVGYDNSFVLGMSVTIFNEFKLYKLLLFPEPDINDVKPPVDEEVSTGNGNTKTSEFEIGSESAGHMNPSNSPNSMDENISHYSVLFKRLYVLLSVFDSLQSCAFGGPKLLNISIQGSTERFFSNDLGSKWCLEQSQLRLKSVLQSLKLGELMSELTRNRISMNGNRKPGFDITNSSSLLSEYVETQPLSVAQLFCKLLIGKHNFINCLLSLYDSEAGVYSDLTLDLSSKIADSLCSLISIILQVLTLILRLNPTNSIDFNYRPPNPPANNPTVQEGPSAMGSSPVAGNLSAAPPSEGNPDFYKKLLGLKQDTGTILSDLCRGIISPFAIAILHEVYNITELVKQMPTSLISIMMTATTTQNTQDTKKSQDLVMKLSNSMNEVVQITSVLTMIKPFKIFEHELNKPIMSLTGGLSSTTRNDVMWPKSGQGLRESSVMKTLLDERRTSGTQPTTAPVAAEEPRLENVALENFVSIGWKLLDDSELGWY
SIO_010081: YKL038W
subclass of: SO_0000673
so part of: YKL038W
location: 365605..369117
location: region:365605-369117:1
so has part: feature:365605-369117:1:exon

NP_012886.3
type: Protein
SIO_000068: ncbiprotein

S000001521
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:365605-369117:1:exon

YKL037W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM26
locus tag: YKL037W
so part of: sequence
location: <369365..>369721
location: region:369365-369721:1
so has part: feature:369365-369721:1:exon
subclass of: SO_0000010

853829
type: Gene
SIO_000068: ncbigene

position:369365:1
position: 369365
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:369721:1
position: 369721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:369365-369721:1:exon

YKL037W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM26
locus tag: YKL037W
product: Aim26p
transcript id: NM_001179603.1
SIO_010081: YKL037W
subclass of: SO_0000673
so part of: YKL037W
location: <369365..>369721
location: region:369365-369721:1
so has part: feature:369365-369721:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:369365-369721:1:exon

YKL037W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM26
locus tag: YKL037W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: hypothetical protein; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
codon start: 1
product: Aim26p
translation: MQTMGGEHLLLSQLKGSFFLLLLAYFFRGRSPYYARCYRRLAVTPGAITIAIAIATDSIPALAKSKVLVSVCSHTDPCTASCNLIPFPRPFSNSLTRFLFCLGSARFCISFPCFGLSI
SIO_010081: YKL037W
subclass of: SO_0000673
so part of: YKL037W
location: 369365..369721
location: region:369365-369721:1
so has part: feature:369365-369721:1:exon

NP_012887.1
type: Protein
SIO_000068: ncbiprotein

S000001520
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:369365-369721:1:exon

YKL035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UGP1
locus tag: YKL035W
so part of: sequence
location: <369891..>371390
location: region:369891-371390:1
so has part: feature:369891-371390:1:exon
subclass of: SO_0000010

853830
type: Gene
SIO_000068: ncbigene

position:369891:1
position: 369891
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371390:1
position: 371390
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:369891-371390:1:exon

YKL035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UGP1
locus tag: YKL035W
product: UTP glucose-1-phosphate uridylyltransferase
transcript id: NM_001179601.3
SIO_010081: YKL035W
subclass of: SO_0000673
so part of: YKL035W
location: <369891..>371390
location: region:369891-371390:1
so has part: feature:369891-371390:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:369891-371390:1:exon

YKL035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UGP1
locus tag: YKL035W
EC number: 2.7.7.9
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0070569 uridylyltransferase activity [PMID:22580055]
experiment: EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]
experiment: EXISTENCE:genetic interaction:GO:0006011 UDP-glucose metabolic process [PMID:9252577]
experiment: EXISTENCE:mutant phenotype:GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity [PMID:7588797]
experiment: EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:9252577]
experiment: EXISTENCE:mutant phenotype:GO:0006011 UDP-glucose metabolic process [PMID:7588797|PMID:9252577]
experiment: EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:17531808]
note: UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
codon start: 1
product: UTP glucose-1-phosphate uridylyltransferase
translation: MSTKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSSKLDDAARAKFENELDSFFTLFRRYLVEKSSRTTLEWDKIKSPNPDEVVKYEIISQQPENVSNLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNTFLDLSVRQIEYLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSLLPVPTEYDSPLDAWYPPGHGDLFESLHVSGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLIESSNLEMEIIPNQKTITRDGHEINVLQLETACGAAIRHFDGAHGVVVPRSRFLPVKTCSDLLLVKSDLFRLEHGSLKLDPSRFGPNPLIKLGSHFKKVSGFNARIPHIPKIVELDHLTITGNVFLGKDVTLRGTVIIVCSDGHKIDIPNGSILENVVVTGNLQILEH
SIO_010081: YKL035W
subclass of: SO_0000673
so part of: YKL035W
location: 369891..371390
location: region:369891-371390:1
so has part: feature:369891-371390:1:exon

NP_012889.3
type: Protein
SIO_000068: ncbiprotein

S000001518
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:369891-371390:1:exon

YKL034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TUL1
locus tag: YKL034W
so part of: sequence
location: <371829..>374105
location: region:371829-374105:1
so has part: feature:371829-374105:1:exon
subclass of: SO_0000010

853832
type: Gene
SIO_000068: ncbigene

position:371829:1
position: 371829
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374105:1
position: 374105
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371829-374105:1:exon

YKL034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TUL1
locus tag: YKL034W
product: ubiquitin-protein ligase TUL1
transcript id: NM_001179600.1
SIO_010081: YKL034W
subclass of: SO_0000673
so part of: YKL034W
location: <371829..>374105
location: region:371829-374105:1
so has part: feature:371829-374105:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371829-374105:1:exon

YKL034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TUL1
locus tag: YKL034W
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11788821]
experiment: EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:11788821]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:11788821]
experiment: EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:11788821]
note: Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
codon start: 1
product: ubiquitin-protein ligase TUL1
translation: MEIDGNTLVFIIVILFLFFSSPGGDGVSSQYEFNQLQRLKQQFRTEHNTFVNMTYTDSFRNITGLKLSYQDMLNNPLQNATYPLPGKDYDRWFPNQNYMVLPNDVIEAINTEVWNTSNDDASNLFPPNITSTLLGKIDLVSNNKYEKIRMPVPRFYEPATDFSEDIPPEGETYWSEWPSYGELHNVSFQHGEIAIQISHMSNLQDNNNYLRRNFINKKNDRWKLLNLQIDFSDKAEKEKHSIYSKAVYDIQRGRILSISQSSKFHSLFALPHYMSFQNDYNEKIFNDVKELVDEFWNFTDYTDVMTMKDVQDAYNNANFKCEYLIFLQLEPWNQYTRDQIKLIDDELNWPLGRPANLSSLPPINVVSGLLYSPDCGVRLGLHNVKGTRYELKIMSIRKHLLFGIALFAAQIYLLLTQMHHTNTPSMVNKISFYCFSMINLVDGSLATLYFVAASVVPELYLPLVISAFSCFILASIFEIRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILIFILNSYWIPQIFRNAVKGIPSRRERARSSIGGNRSQNKMPLLWSFVIGTTIIRSLPVVYVFTYSSNVFRHHKDVHFVVFLSLWLLFQISILYSQDVLGSRWFLPKHTIPDGYSYFKPLSNEYISEHGGGTAEHTVDCAICMSDVPIYIEEIPETHKVDQHSYMVTPCNHVFHTSCLENWMNYKLQCPVCRSPLPPL
SIO_010081: YKL034W
subclass of: SO_0000673
so part of: YKL034W
location: 371829..374105
location: region:371829-374105:1
so has part: feature:371829-374105:1:exon

NP_012890.1
type: Protein
SIO_000068: ncbiprotein

S000001517
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371829-374105:1:exon

YKL033W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKL033W-A
so part of: sequence
location: <374505..>375215
location: region:374505-375215:1
so has part: feature:374505-375215:1:exon
subclass of: SO_0000010

853833
type: Gene
SIO_000068: ncbigene

position:374505:1
position: 374505
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:375215:1
position: 375215
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374505-375215:1:exon

YKL033W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKL033W-A
product: putative hydrolase
transcript id: NM_001184335.3
SIO_010081: YKL033W-A
subclass of: SO_0000673
so part of: YKL033W-A
location: <374505..>375215
location: region:374505-375215:1
so has part: feature:374505-375215:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:374505-375215:1:exon

YKL033W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKL033W-A
EC number: 3.1.3.96
experiment: EXISTENCE:direct assay:GO:0008253 5'-nucleotidase activity [PMID:26071590]
experiment: EXISTENCE:direct assay:GO:1990738 pseudouridine 5'-phosphatase activity [PMID:26071590]
note: hypothetical protein; similar to uncharacterized proteins from other fungi
codon start: 1
product: putative hydrolase
translation: MTHPVAVKACLFDMDGLLINTEDIYTETLNETLAEFGKGPLTWDVKIKLQGLPGPEAGKRVIEHYKLPITLDEYDERNVALQSLKWGTCEFLPGALNLLKYLKLKNIPIALCTSSNKTKFRGKTSHLEEGFDLFDTIVTGDDPRIAKGRGKPFPDIWQLGLKELNEKFHTDIKPDECIVFEDGIPGVKSAKAFGAHVIWVPHPEAHAVLGDTEALLAGKGELLSSLEKLEMSKYGL
SIO_010081: YKL033W-A
subclass of: SO_0000673
so part of: YKL033W-A
location: 374505..375215
location: region:374505-375215:1
so has part: feature:374505-375215:1:exon

NP_012891.4
type: Protein
SIO_000068: ncbiprotein

S000007242
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374505-375215:1:exon

YKL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TTI1
locus tag: YKL033W
so part of: sequence
location: <375456..>378572
location: region:375456-378572:1
so has part: feature:375456-378572:1:exon
subclass of: SO_0000010

853834
type: Gene
SIO_000068: ncbigene

position:375456:1
position: 375456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:378572:1
position: 378572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375456-378572:1:exon

YKL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TTI1
locus tag: YKL033W
product: Tti1p
transcript id: NM_001179599.1
SIO_010081: YKL033W
subclass of: SO_0000673
so part of: YKL033W
location: <375456..>378572
location: region:375456-378572:1
so has part: feature:375456-378572:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:375456-378572:1:exon

YKL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TTI1
locus tag: YKL033W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0070209 ASTRA complex [PMID:19040720]
note: Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Tti1p
translation: MNSDTNAFKDIRISCVELSRIAFLPTESFDPNSLTLLACLKKVEEKLSAYEDDSLSPKFADYVFVPIASLLKQPALGESQTEYVLLIIFHLLRTCWSSNGKFSEQLGQQLFPLITFLVSSDKDNQKLITRSDEFKYAGCLVLHQFFKSVRSQRYHKEFFSNSKPNLLPALGHSVTILLKILEQSPQNNELQFKALASLEVLFQDIISDGEMLSFILPGNVSVFAKILTKPGRQIHYKVCVRTLEVLAKLLVLVYDDFSLDIKVNKLTDIRELSDTKLKHEINQSFMFNGPIVLLRTDGKTHRDTSWLTATSGQINIALEAFIPKLLKRNNESIDEALATFVSILLTRCENSLNNCEKVLVSTLVHLERDPMSKLPSHLVKLKEVVNEDLHKLSDIIRFENADRLSSLSFAITILEKNNERDTMINEVVRCLFESLNESIEPPSLINHKERIIEQSSQLTTTVNFENLESTNALIALPRLSEDMSLKLKKFTYHMGSLLLERHILNDVVTELISEQVDSPRTQKIVALWLSTNFIKAMEKQPKEEEVYLQFESDANYSSSMVEEVCLIVLEFCNELSQDISMEIEGKGIKKSDEFAVCTVLFSIETICAVMREEFQPELIDYIYTVVDALASPSEAIRYVSQSCALRIADTLYHGSIPNMILSNVDYLVESISSRLNSGMTERVSQILMVICQLAGYETIENFKDVIETIFKLLDYYHGYSDLCLQFFQLFKIIILEMKKKYINDDEMILKIANQHISQSTFSPWGMTDFQQVLNILDKETQVKDDITDENDVDFLKDDNEPSNFQEYFDSKLREPDSDDDEEEREEEVEGSSKEYTDQWTSPIPSDSYKILLQILGYGERLLTHPSKRLRVQILIVMRLIFPLLSTQHNLLIREVASTWDSIIQCVLCSDYSIVQPACSCVEQMIKYSGDFVAKRFIELWQKLCQDSFILKELRIDPTVHNHEKKSISKHVKFPPVTENALVSMVHMVLEGVKITEYLISEAVLEQIIYCCIQVVPVEKISSMSLIVGDIVWKIRNIN
SIO_010081: YKL033W
subclass of: SO_0000673
so part of: YKL033W
location: 375456..378572
location: region:375456-378572:1
so has part: feature:375456-378572:1:exon

NP_012892.1
type: Protein
SIO_000068: ncbiprotein

S000001516
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375456-378572:1:exon

YNCK0014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0014W
so part of: sequence
location: 379680..379753
location: region:379680-379753:1
so has part: feature:379680-379753:1:exon
subclass of: SO_0000663

853835
type: Gene
SIO_000068: ncbigene

position:379680:1
position: 379680
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:379753:1
position: 379753
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379680-379753:1:exon

YNCK0014W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0014W
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0014W
subclass of: SO_0000673
so part of: YNCK0014W
location: 379680..379753
location: region:379680-379753:1
so has part: feature:379680-379753:1:exon

S000006761
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:379680-379753:1:exon

YKL032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ORD1
gene: IXR1
locus tag: YKL032C
gene synonym: ORD1
so part of: sequence
location: complement(<380065..>381858)
location: region:380065-381858:-1
so has part: feature:380065-381858:-1:exon
subclass of: SO_0000010

853836
type: Gene
SIO_000068: ncbigene

position:380065:-1
position: 380065
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:381858:-1
position: 381858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:380065-381858:-1:exon

YKL032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ORD1
gene: IXR1
locus tag: YKL032C
gene synonym: ORD1
product: DNA-binding transcription repressor IXR1
transcript id: NM_001179598.3
SIO_010081: YKL032C
subclass of: SO_0000673
so part of: YKL032C
location: complement(<380065..>381858)
location: region:380065-381858:-1
so has part: feature:380065-381858:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380065-381858:-1:exon

YKL032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ORD1
gene: IXR1
locus tag: YKL032C
gene synonym: ORD1
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:19807692]
experiment: EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:29449612]
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:8634251]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:11115121|PMID:19807692]
experiment: EXISTENCE:genetic interaction:GO:0071456 cellular response to hypoxia [PMID:19807692]
experiment: EXISTENCE:genetic interaction:GO:2000819 regulation of nucleotide-excision repair [PMID:8538651]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11115121]
experiment: EXISTENCE:mutant phenotype:GO:0071456 cellular response to hypoxia [PMID:19807692]
experiment: EXISTENCE:mutant phenotype:GO:0090069 regulation of ribosome biogenesis [PMID:29449612]
note: Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication
codon start: 1
product: DNA-binding transcription repressor IXR1
translation: MNTGISPKQDDASNSNLLNIGQDHSLQYQGLEHNDSQYRDASHQTPHQYLNQFQAQPQQQQQQQQQQQQQQQQAPYQGHFQQSPQQQQQNVYYPLPPQSLTQPTSQSQQQQQQQQQQQYANSNSNSNNNVNVNALPQDFGYMQQTGSGQNYPTINQQQFSEFYNSFLSHLTQKQTNPSVTGTGASSNNNSNNNNVSSGNNSTSSNPAQLAASQLNPATAAAAAANNAAGPASYLSQLPQVQRYYPNNMNALSSLLDPSSAGNAAGNANTATHPGLLPPNLQPQLTHHQQQMQQQLQLQQQQQLQQQQQLQQQHQLQQQQQLQQQHHHLQQQQQQQQHPVVKKLSSTQSRIERRKQLKKQGPKRPSSAYFLFSMSIRNELLQQFPEAKVPELSKLASARWKELTDDQKKPFYEEFRTNWEKYRVVRDAYEKTLPPKRPSGPFIQFTQEIRPTVVKENPDKGLIEITKIIGERWRELDPAKKAEYTETYKKRLKEWESCYPDENDPNGNPTGHSHKAMNMNLNMDTKIMENQDSIEHITANAIDSVTGSNSNSTNPNTPVSPPISLQQQPLQQQQQQQQQQQHMLLADPTTNGSIIKNE
SIO_010081: YKL032C
subclass of: SO_0000673
so part of: YKL032C
location: complement(380065..381858)
location: region:380065-381858:-1
so has part: feature:380065-381858:-1:exon

NP_012893.3
type: Protein
SIO_000068: ncbiprotein

S000001515
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380065-381858:-1:exon

YKL029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAE1
locus tag: YKL029C
so part of: sequence
location: complement(<382716..>384725)
location: region:382716-384725:-1
so has part: feature:382716-384725:-1:exon
subclass of: SO_0000010

853839
type: Gene
SIO_000068: ncbigene

position:382716:-1
position: 382716
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384725:-1
position: 384725
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:382716-384725:-1:exon

YKL029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAE1
locus tag: YKL029C
product: malate dehydrogenase (oxaloacetate-decarboxylating)
transcript id: NM_001179595.1
SIO_010081: YKL029C
subclass of: SO_0000673
so part of: YKL029C
location: complement(<382716..>384725)
location: region:382716-384725:-1
so has part: feature:382716-384725:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:382716-384725:-1:exon

YKL029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAE1
locus tag: YKL029C
EC number: 1.1.1.38
experiment: EXISTENCE:direct assay:GO:0004470 malic enzyme activity [PMID:9603875]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9603875|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0006090 pyruvate metabolic process [PMID:9603875]
experiment: EXISTENCE:mutant phenotype:GO:0006520 amino acid metabolic process [PMID:9603875]
note: Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
codon start: 1
product: malate dehydrogenase (oxaloacetate-decarboxylating)
translation: MLRTRLSVSVAARSQLTRSLTASRTAPLRRWPIQQSRLYSSNTRSHKATTTRENTFQKPYSDEEVTKTPVGSRARKIFEAPHPHATRLTVEGAIECPLESFQLLNSPLFNKGSAFTQEEREAFNLEALLPPQVNTLDEQLERSYKQLCYLKTPLAKNDFMTSLRVQNKVLYFALIRRHIKELVPIIYTPTEGDAIAAYSHRFRKPEGVFLDITEPDSIECRLATYGGDKDVDYIVVSDSEGILGIGDQGIGGVRIAISKLALMTLCGGIHPGRVLPVCLDVGTNNKKLARDELYMGNKFSRIRGKQYDDFLEKFIKAVKKVYPSAVLHFEDFGVKNARRLLEKYRYELPSFNDDIQGTGAVVMASLIAALKHTNRDLKDTRVLIYGAGSAGLGIADQIVNHMVTHGVDKEEARKKIFLMDRRGLILQSYEANSTPAQHVYAKSDAEWAGINTRSLHDVVENVKPTCLVGCSTQAGAFTQDVVEEMHKHNPRPIIFPLSNPTRLHEAVPADLMKWTNNNALVATGSPFPPVDGYRISENNNCYSFPGIGLGAVLSRATTITDKMISAAVDQLAELSPLREGDSRPGLLPGLDTITNTSARLATAVILQALEEGTARIEQEQVPGGAPGETVKVPRDFDECLQWVKAQMWEPVYRPMIKVQHDPSVHTNQL
SIO_010081: YKL029C
subclass of: SO_0000673
so part of: YKL029C
location: complement(382716..384725)
location: region:382716-384725:-1
so has part: feature:382716-384725:-1:exon

NP_012896.1
type: Protein
SIO_000068: ncbiprotein

S000001512
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:382716-384725:-1:exon

YKL028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TFA1
locus tag: YKL028W
so part of: sequence
location: <385758..>387206
location: region:385758-387206:1
so has part: feature:385758-387206:1:exon
subclass of: SO_0000010

853840
type: Gene
SIO_000068: ncbigene

position:385758:1
position: 385758
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:387206:1
position: 387206
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:385758-387206:1:exon

YKL028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TFA1
locus tag: YKL028W
product: transcription factor TFIIE subunit TFA1
transcript id: NM_001179594.3
SIO_010081: YKL028W
subclass of: SO_0000673
so part of: YKL028W
location: <385758..>387206
location: region:385758-387206:1
so has part: feature:385758-387206:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:385758-387206:1:exon

YKL028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TFA1
locus tag: YKL028W
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:8702741]
experiment: EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:8702741]
experiment: EXISTENCE:direct assay:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:10973956]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9271406]
experiment: EXISTENCE:direct assay:GO:0005673 transcription factor TFIIE complex [PMID:1429681|PMID:7961670]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:1331084|PMID:1429681|PMID:7961670]
experiment: EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]
experiment: EXISTENCE:genetic interaction:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:10973956]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9188494|PMID:9271406]
experiment: EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:11779853]
note: TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
codon start: 1
product: transcription factor TFIIE subunit TFA1
translation: MDRPIDDIVKNLLKFVVRGFYGGSFVLVLDAILFHSVLAEDDLKQLLSINKTELGPLIARLRSDRLISIHKQREYPPNSKSVERVYYYVKYPHAIDAIKWKVHQVVQRLKDDLDKNSEPNGYMCPICLTKYTQLEAVQLLNFDRTEFLCSLCDEPLVEDDSGKKNKEKQDKLNRLMDQIQPIIDSLKKIDDSRIEENTFEIALARLIPPQNQSHAAYTYNPKKGSTMFRPGDSAPLPNLMGTALGNDSSRRAGANSQATLHINITTASDEVAQRELQERQAEEKRKQNAVPEWHKQSTIGKTALGRLDNEEEFDPVVTASAMDSINPDNEPAQETSYQNNRTLTEQEMEERENEKTLNDYYAALAKKQAKLNKEEEEEEEEEEDEEEEEEEEMEDVMDDNDETARENALEDEFEDVTDTAGTAKTESNTSNDVKQESINDKTEDAVNATATASGPSANAKPNDGDDDDDDDDDEMDIEFEDV
SIO_010081: YKL028W
subclass of: SO_0000673
so part of: YKL028W
location: 385758..387206
location: region:385758-387206:1
so has part: feature:385758-387206:1:exon

NP_012897.3
type: Protein
SIO_000068: ncbiprotein

S000001511
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:385758-387206:1:exon

YKL027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCD2
locus tag: YKL027W
so part of: sequence
location: <387562..>388905
location: region:387562-388905:1
so has part: feature:387562-388905:1:exon
subclass of: SO_0000010

853841
type: Gene
SIO_000068: ncbigene

position:387562:1
position: 387562
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388905:1
position: 388905
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387562-388905:1:exon

YKL027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCD2
locus tag: YKL027W
product: tRNA threonylcarbamoyladenosine dehydratase
transcript id: NM_001179593.1
SIO_010081: YKL027W
subclass of: SO_0000673
so part of: YKL027W
location: <387562..>388905
location: region:387562-388905:1
so has part: feature:387562-388905:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387562-388905:1:exon

YKL027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCD2
locus tag: YKL027W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:mutant phenotype:GO:0061503 tRNA threonylcarbamoyladenosine dehydratase [PMID:23242255]
experiment: EXISTENCE:mutant phenotype:GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process [PMID:23242255]
note: tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication
codon start: 1
product: tRNA threonylcarbamoyladenosine dehydratase
translation: MVEKDTWKLITATALFTVAVTTITDYAWTSWQAQKQVIAQQKNKNKGGQTKSDTDKYHQYDEQFIRQSLKNNVEFLGEDTIEKLSNQYVVVVGAGGVGSWVVNSLVRSGCRKIRVVDFDQVSLSSLNRHSCAILNDVGTPKVECLRRHMREIAPWCEIDPINELWTLQNGERLTLGNGTPDFIVDCIDNIDTKVDLLEFAYNHGIKVISSMGASAKSDPTKLNVGDLATTEEDPLARVVRRKLKKRGILSGIPVVFSAEKPDPKKAKLLPLPDEEYERGKVDELSALKDFRVRILPVLGTMPSLFGLTITTWILSNISDKPLEPVEGKNRIKVYDGIYQSLAGQMSRVGIPSQRIPLALKDVSYLVEEVFKGKSPISGISTRLTLTKWDPSKPISLQNVVVLTKNEQKVHEDRVLKGKESLQDVYDAKVLKLVSQRFREEAYYSQFR
SIO_010081: YKL027W
subclass of: SO_0000673
so part of: YKL027W
location: 387562..388905
location: region:387562-388905:1
so has part: feature:387562-388905:1:exon

NP_012898.1
type: Protein
SIO_000068: ncbiprotein

S000001510
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387562-388905:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1112; Autonomously Replicating Sequence
so part of: sequence
location: 388970..389264
location: region:388970-389264:1
so has part: feature:388970-389264:1:region

S000118404
type: SGD
SIO_000068: sgd

position:388970:1
position: 388970
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:389264:1
position: 389264
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388970-389264:1:region

YKL026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPX1
locus tag: YKL026C
so part of: sequence
location: complement(<389380..>389883)
location: region:389380-389883:-1
so has part: feature:389380-389883:-1:exon
subclass of: SO_0000010

853842
type: Gene
SIO_000068: ncbigene

position:389380:-1
position: 389380
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:389883:-1
position: 389883
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389380-389883:-1:exon

YKL026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPX1
locus tag: YKL026C
product: glutathione peroxidase GPX1
transcript id: NM_001179592.3
SIO_010081: YKL026C
subclass of: SO_0000673
so part of: YKL026C
location: complement(<389380..>389883)
location: region:389380-389883:-1
so has part: feature:389380-389883:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:389380-389883:-1:exon

YKL026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPX1
locus tag: YKL026C
EC number: 1.11.1.9
EC number: 1.11.1.24
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:22659048]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]
experiment: EXISTENCE:mutant phenotype:GO:0004602 glutathione peroxidase activity [PMID:10480913]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:22659048]
experiment: EXISTENCE:mutant phenotype:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]
note: Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; GPX1 has a paralog, HYR1, that arose from the whole genome duplication
codon start: 1
product: glutathione peroxidase GPX1
translation: MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIVAFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGIKMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI
SIO_010081: YKL026C
subclass of: SO_0000673
so part of: YKL026C
location: complement(389380..389883)
location: region:389380-389883:-1
so has part: feature:389380-389883:-1:exon

NP_012899.3
type: Protein
SIO_000068: ncbiprotein

S000001509
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:389380-389883:-1:exon

YKL025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECM35
gene: PAN3
locus tag: YKL025C
gene synonym: ECM35
so part of: sequence
location: complement(<390240..>392279)
location: region:390240-392279:-1
so has part: feature:390240-392279:-1:exon
subclass of: SO_0000010

853843
type: Gene
SIO_000068: ncbigene

position:390240:-1
position: 390240
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:392279:-1
position: 392279
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390240-392279:-1:exon

YKL025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECM35
gene: PAN3
locus tag: YKL025C
gene synonym: ECM35
product: Pan3p
transcript id: NM_001179591.1
SIO_010081: YKL025C
subclass of: SO_0000673
so part of: YKL025C
location: complement(<390240..>392279)
location: region:390240-392279:-1
so has part: feature:390240-392279:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390240-392279:-1:exon

YKL025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECM35
gene: PAN3
locus tag: YKL025C
gene synonym: ECM35
experiment: EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8816488]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:24872509]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11953437]
experiment: EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:24872509]
experiment: EXISTENCE:direct assay:GO:0031251 PAN complex [PMID:8816488]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:11953437]
experiment: EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8816488]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:24872509]
experiment: EXISTENCE:mutant phenotype:GO:0008143 poly(A) binding [PMID:24872509]
experiment: EXISTENCE:physical interaction:GO:0006301 postreplication repair [PMID:11953437]
note: Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes
codon start: 1
product: Pan3p
translation: MDKINPDWAKDIPCRNITIYGYCKKEKEGCPFKHSDNTTATTINDVPPPIDVGEATTPTMTSVPKFNAKVSASFTPMTVGSDSLTTVTNTTSAATNATGNIAMAATSATASTVNPMINPIVNSSLVNNNNNNSNISISIPTTASSSNYDPFNAPIFTPSSTSSIHTNANAHSFPFPSIANSGGININATDDNSNNMSMANNVPPPMQPPPIESSNLKYPRIYPPPHSLLQYHLYAPEQPSSLKSLLKPNERSADQLFIPNNIREDLTKKNLSILQVFPSSGKVIPSIVQDYFNLVPLNFNNNDFLNKTTLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNWRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSGGSTIEGQQQLDYKYLGELLFNLSINIENSNNNTAPKEYRLEEITPQSIDDMRQIDDKFKDVLKYLISDNGDSKKSIHDLTSHFYDKMFMVLESSQTYTEYMESVLSRELENGRLFRLVNKLNCIFGRIESRIDINWSESGTKFPIILFYDYVFHQVDSNGKPIMDLTHVLRCLNKLDAGIQEKLMLVTPDELNCIIISYKELKDLIESTFRSITQ
SIO_010081: YKL025C
subclass of: SO_0000673
so part of: YKL025C
location: complement(390240..392279)
location: region:390240-392279:-1
so has part: feature:390240-392279:-1:exon

NP_012900.1
type: Protein
SIO_000068: ncbiprotein

S000001508
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390240-392279:-1:exon

YKL024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SOC8
gene: URA6
locus tag: YKL024C
gene synonym: SOC8
so part of: sequence
location: complement(<392526..>393140)
location: region:392526-393140:-1
so has part: feature:392526-393140:-1:exon
subclass of: SO_0000010

853844
type: Gene
SIO_000068: ncbigene

position:392526:-1
position: 392526
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393140:-1
position: 393140
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392526-393140:-1:exon

YKL024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SOC8
gene: URA6
locus tag: YKL024C
gene synonym: SOC8
product: bifunctional uridylate/adenylate kinase
transcript id: NM_001179590.3
SIO_010081: YKL024C
subclass of: SO_0000673
so part of: YKL024C
location: complement(<392526..>393140)
location: region:392526-393140:-1
so has part: feature:392526-393140:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392526-393140:-1:exon

YKL024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SOC8
gene: URA6
locus tag: YKL024C
gene synonym: SOC8
EC number: 2.7.4.14
experiment: EXISTENCE:direct assay:GO:0004017 adenylate kinase activity [PMID:1333436]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8391780]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8391780]
experiment: EXISTENCE:direct assay:GO:0006139 nucleobase-containing compound metabolic process [PMID:2549068]
experiment: EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:8391780]
experiment: EXISTENCE:direct assay:GO:0009041 uridylate kinase activity [PMID:1655742|PMID:2549068]
experiment: EXISTENCE:genetic interaction:GO:0004017 adenylate kinase activity [PMID:1333436]
experiment: EXISTENCE:mutant phenotype:GO:0009041 uridylate kinase activity [PMID:1655742]
note: Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
codon start: 1
product: bifunctional uridylate/adenylate kinase
translation: MTAATTSQPAFSPDQVSVIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKHKFLIDGFPRKMDQAISFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIRDSL
SIO_010081: YKL024C
subclass of: SO_0000673
so part of: YKL024C
location: complement(392526..393140)
location: region:392526-393140:-1
so has part: feature:392526-393140:-1:exon

NP_012901.3
type: Protein
SIO_000068: ncbiprotein

S000001507
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392526-393140:-1:exon

YKL023C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIN9
locus tag: YKL023C-A
so part of: sequence
location: complement(<393146..>393373)
location: region:393146-393373:-1
so has part: feature:393146-393373:-1:exon
subclass of: SO_0000010

3799976
type: Gene
SIO_000068: ncbigene

position:393146:-1
position: 393146
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393373:-1
position: 393373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:393146-393373:-1:exon

YKL023C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIN9
locus tag: YKL023C-A
product: Min9p
transcript id: NM_001184683.1
SIO_010081: YKL023C-A
subclass of: SO_0000673
so part of: YKL023C-A
location: complement(<393146..>393373)
location: region:393146-393373:-1
so has part: feature:393146-393373:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:393146-393373:-1:exon

YKL023C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIN9
locus tag: YKL023C-A
note: Mitochondrial hypothetical protein
codon start: 1
product: Min9p
translation: MNPRYRFILRFYSSKKPTFHNTAPSKTNVNVPRANKSQSKGKHKGKLLVLVGTLALVTSVISVNYQKNEPVEFLE
SIO_010081: YKL023C-A
subclass of: SO_0000673
so part of: YKL023C-A
location: complement(393146..393373)
location: region:393146-393373:-1
so has part: feature:393146-393373:-1:exon

NP_001032581.1
type: Protein
SIO_000068: ncbiprotein

S000113559
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:393146-393373:-1:exon

YKL023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKA1
locus tag: YKL023W
so part of: sequence
location: <393721..>394554
location: region:393721-394554:1
so has part: feature:393721-394554:1:exon
subclass of: SO_0000010

853845
type: Gene
SIO_000068: ncbigene

position:393721:1
position: 393721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394554:1
position: 394554
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:393721-394554:1:exon

YKL023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKA1
locus tag: YKL023W
product: Ska1p
transcript id: NM_001179589.4
SIO_010081: YKL023W
subclass of: SO_0000673
so part of: YKL023W
location: <393721..>394554
location: region:393721-394554:1
so has part: feature:393721-394554:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:393721-394554:1:exon

YKL023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKA1
locus tag: YKL023W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:31304628]
note: SKI complex-associated protein; involved in 3'-5' degradation of long 3'UTR-containing mRNA, poorly translated mRNA, and other RNA regions devoid of ribosomes; proposed to assist the cytoplasmic exosome in a Ska1-SKI complex when a direct interaction between the ribosome and the SKI complex is absent
codon start: 1
product: Ska1p
translation: MNKEELLGFLLDDSIDSQKRCVTDQQAYSNWLKNDNDERTAHEESSSQSTIAALNKKKQTEAAQEDIEELLNGLEGIIGGADPRNLKSKSKRKTKKGGSKPREENVNTEKHIVMLEVEDFSDMSTHEDVNGASPSPNLDRSKKNEKRRKNAKELSYDELKDKLEVTTRKSRLECKDLKKKVHGLERRNLELEQRLEELKIENQTLIEINNKLLKNTNEDEINKSQRNKEKDRKRRERRTARRKDERKQEKKQEKKQDNKTSQSFPSSTDMNGQPIEF
SIO_010081: YKL023W
subclass of: SO_0000673
so part of: YKL023W
location: 393721..394554
location: region:393721-394554:1
so has part: feature:393721-394554:1:exon

NP_012902.4
type: Protein
SIO_000068: ncbiprotein

S000001506
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:393721-394554:1:exon

YKL022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC16
locus tag: YKL022C
so part of: sequence
location: complement(<394726..>397248)
location: region:394726-397248:-1
so has part: feature:394726-397248:-1:exon
subclass of: SO_0000010

853846
type: Gene
SIO_000068: ncbigene

position:394726:-1
position: 394726
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397248:-1
position: 397248
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394726-397248:-1:exon

YKL022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC16
locus tag: YKL022C
product: anaphase promoting complex subunit CDC16
transcript id: NM_001179588.1
SIO_010081: YKL022C
subclass of: SO_0000673
so part of: YKL022C
location: complement(<394726..>397248)
location: region:394726-397248:-1
so has part: feature:394726-397248:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394726-397248:-1:exon

YKL022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC16
locus tag: YKL022C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0032297 negative regulation of DNA-templated DNA replication initiation [PMID:9660930]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29883473]
note: Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: anaphase promoting complex subunit CDC16
translation: MKFCLYCCHCYIVICGKATHYYKSSKATSNLKSSNRVLMRNPMSPSEQHSQHNSTLAASPFVSNVSAARTQQSLPTDAQNDRLQQPWNRTNTATSPYQSLANSPLIQKLQANIMTPHQPSANSNSNSNSITGNVVNDNNLLASMSKNSMFGSTIPSTLRKVSLQREYKDSVDGVVRDEDNDEDVHNNGDAAANANNDRESKLGHNGPLTTTTLTTTTTATQLDVSELSAIERLRLWRFDALMQHMYRTAEYIADKVYNISNDPDDAFWLGQVYYNNNQYVRAVELITRNNLDGVNILCRYLLGLSFVKLQRFDDALDVIGEYNPFSEDPSTTAANTMSNNGNNSNTSQPVTDGGIKMESSLCFLRGKIYFAQNNFNKARDAFREAILVDIKNFEAFEMLLSKNLLTPQEEWDLFDSLDFKEFGEDKEIMKNLYKINLSKYINTEDITKSNEILAKDYKLADNVDVVRSKVDICYTQCKFNECLELCETVLENDEFNTNILPAYIGCLYELSNKNKLFLLSHRLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYLKKALEVVKDLDPSSRTTISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALELNVTLSLDASHPLIDKSNLMSQASKDKASLNKKRSSLTYDPVNMAKRLRTQKEIFDQNNKALRKGGHDSKTGSNNADDDFDADMELE
SIO_010081: YKL022C
subclass of: SO_0000673
so part of: YKL022C
location: complement(394726..397248)
location: region:394726-397248:-1
so has part: feature:394726-397248:-1:exon

NP_012903.1
type: Protein
SIO_000068: ncbiprotein

S000001505
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394726-397248:-1:exon

YKL021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAK11
locus tag: YKL021C
so part of: sequence
location: complement(<397344..>398750)
location: region:397344-398750:-1
so has part: feature:397344-398750:-1:exon
subclass of: SO_0000010

853847
type: Gene
SIO_000068: ncbigene

position:397344:-1
position: 397344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:398750:-1
position: 398750
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397344-398750:-1:exon

YKL021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAK11
locus tag: YKL021C
product: Mak11p
transcript id: NM_001179587.3
SIO_010081: YKL021C
subclass of: SO_0000673
so part of: YKL021C
location: complement(<397344..>398750)
location: region:397344-398750:-1
so has part: feature:397344-398750:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397344-398750:-1:exon

YKL021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAK11
locus tag: YKL021C
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:2826479]
experiment: EXISTENCE:genetic interaction:GO:0000027 ribosomal large subunit assembly [PMID:17308036]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:17308036]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17308036]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17308036]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:7739558]
experiment: EXISTENCE:physical interaction:GO:0000027 ribosomal large subunit assembly [PMID:17308036]
note: Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
codon start: 1
product: Mak11p
translation: MLLNTTYTVFIFFLLRIIKFKIKAENFLEHEKLKTHGTSSRKDPKGQVKNSCRKMSAIGDKNQFRIIVGSYEHNILCLSLDIPNQKENDAAKTPHFMPIFHFQAHSLSIKCLAVSRRYLVSGSNDEHIRIYDLQKRKELGTLLSHQGSITALQFSHPASSSEDAAVSKGSKNSKWLLSASEDHKIMVWRVKDWETVGTLKGHTARVNDVDIHPTNRIAISVSDDHSIRLWNLMTLRNAAVLKLRKYNTNGTCVRWLGAKGDYFAVGLRDRVLIYETGSAKVFKEIVFQRKTLMHIETHILPFDNKEYLSVGISDGNVHFYPCEELFEKVEENEKQEDDDDKEDISPAFSLLGHTNRIKDFKFYTNEFGTYLVTIGSDGKIVVWDMSTKEQVAVYDCGERLNCLTLCDESIEKYNTMKKRDAETADIGDQSEVESDTEELKKIMFGEKKKLNKKKRKQLKKSKVSVELE
SIO_010081: YKL021C
subclass of: SO_0000673
so part of: YKL021C
location: complement(397344..398750)
location: region:397344-398750:-1
so has part: feature:397344-398750:-1:exon

NP_012904.3
type: Protein
SIO_000068: ncbiprotein

S000001504
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397344-398750:-1:exon

YKL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPT23
locus tag: YKL020C
so part of: sequence
location: complement(<398832..>402080)
location: region:398832-402080:-1
so has part: feature:398832-402080:-1:exon
subclass of: SO_0000010

853848
type: Gene
SIO_000068: ncbigene

position:398832:-1
position: 398832
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402080:-1
position: 402080
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:398832-402080:-1:exon

YKL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPT23
locus tag: YKL020C
product: Spt23p
transcript id: NM_001179586.1
SIO_010081: YKL020C
subclass of: SO_0000673
so part of: YKL020C
location: complement(<398832..>402080)
location: region:398832-402080:-1
so has part: feature:398832-402080:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:398832-402080:-1:exon

YKL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPT23
locus tag: YKL020C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11007476]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11007476]
experiment: EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11063674]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9927444]
experiment: EXISTENCE:genetic interaction:GO:0070417 cellular response to cold [PMID:11855848]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11557770]
note: ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication
codon start: 1
product: Spt23p
translation: MMSGTGNVSSMLHSYSANIQHNDGSPDLDLLESELLDIALLNSGSSLQDPGLLSLNQEKMITAGTTTPGKEDEGELRDDIASLQGLLDRHVQFGRKLPLRTPYANPLDFININPQSLPLSLEIIGLPKVSRVETQMKLSFRIRNAHARKNFFIHLPSDCIAKDKFFTSSDDPTNLTIPNRDINERTLFLDAFLLCASNNNSNNFKQTYVCNRCINREKRRASRRKSGLNDNSIWQNNENKRAIIFNSKQLFIISNNGLSGNSNCINFDLPTRIVCYCRHHKATNGFVVLFLLRDHNGDILAKTITDPIMIMDKKNASNTTTPTSTSNAQVSPMTNDTRSFSSPQSDLNFPSEFPLPSNSKNFVISTNCMLDSNCNNNNNDNDNKNNIKTNTAMMNNNRHFPSPNSSSEDSNHSFSDIHFSNNNDNNLHRSLDSWSSTGFNSSSNPALTTLTSDFSAASARHTGKRQRSVNEPFMSTPNTFSRLPQKFIDSSKDISNHNSVPVALNNKPSIQRVIPAQGSINGGIEVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVTYLPPSSKPGPVLVTIVDPSETSMRNNSNSSVSTSNSTNDILHLNKYTGEKAIFTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGSDSSPSNNNAGLHSQNSSLNSYTNMMRNINDEQLITEVIKSFKRNNNLSTVNLSMCDVRGRTLLHLAAFNNWYSLVSLLIKYGSHLNDQDLFGFTPLHMACINGDLRIIRLLLECNVNIMKKTRNGFIAKQFFLMNYTVNKTRYSNYETSLFDDILTRLTKNTTGSSDTQPFERNVSQSSFNSSLFDDDDADHDYVQERKYLLADSAALAPEQSNCNDNTSFSILDSDSGYDISDCESSSDEIALEFFNTHKIKDFSSKPNEIPKTTKTSIEPDGSLWNRMLTRLNDELPKYEDLFPKKPKNWELGSKSVEIGPDNSAQMTVDDSQTSSEDDELEALQVGFNTIFSKKQNFQNDKMLLFFWIPLTLVLLLCFTLSNLGKDDDMFHNLSKIVQEYLRIGLAKVLLGNERMKTSFKMQLSKFQNNNILNDMRVN
SIO_010081: YKL020C
subclass of: SO_0000673
so part of: YKL020C
location: complement(398832..402080)
location: region:398832-402080:-1
so has part: feature:398832-402080:-1:exon

NP_012905.1
type: Protein
SIO_000068: ncbiprotein

S000001503
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:398832-402080:-1:exon

YKL019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAM2
locus tag: YKL019W
so part of: sequence
location: <402568..>403518
location: region:402568-403518:1
so has part: feature:402568-403518:1:exon
subclass of: SO_0000010

853849
type: Gene
SIO_000068: ncbigene

position:402568:1
position: 402568
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:403518:1
position: 403518
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402568-403518:1:exon

YKL019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAM2
locus tag: YKL019W
product: bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
transcript id: NM_001179585.3
SIO_010081: YKL019W
subclass of: SO_0000673
so part of: YKL019W
location: <402568..>403518
location: region:402568-403518:1
so has part: feature:402568-403518:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402568-403518:1:exon

YKL019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAM2
locus tag: YKL019W
EC number: 2.5.1.58
EC number: 2.5.1.59
experiment: EXISTENCE:direct assay:GO:0004660 protein farnesyltransferase activity [PMID:1763050]
experiment: EXISTENCE:direct assay:GO:0004661 protein geranylgeranyltransferase activity [PMID:2034682]
experiment: EXISTENCE:direct assay:GO:0004662 CAAX-protein geranylgeranyltransferase activity [PMID:1400380]
experiment: EXISTENCE:direct assay:GO:0005953 CAAX-protein geranylgeranyltransferase complex [PMID:1400380]
experiment: EXISTENCE:direct assay:GO:0005965 protein farnesyltransferase complex [PMID:1763050]
experiment: EXISTENCE:direct assay:GO:0007323 peptide pheromone maturation [PMID:1763050]
experiment: EXISTENCE:direct assay:GO:0018343 protein farnesylation [PMID:1763050]
experiment: EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:1400380]
note: Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor
codon start: 1
product: bifunctional protein farnesyltransferase/protein geranylgeranyltransferase
translation: MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
SIO_010081: YKL019W
subclass of: SO_0000673
so part of: YKL019W
location: 402568..403518
location: region:402568-403518:1
so has part: feature:402568-403518:1:exon

NP_012906.3
type: Protein
SIO_000068: ncbiprotein

S000001502
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402568-403518:1:exon

YKL018C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCO12
locus tag: YKL018C-A
so part of: sequence
location: complement(<403580..>403879)
location: region:403580-403879:-1
so has part: feature:403580-403879:-1:exon
subclass of: SO_0000010

853850
type: Gene
SIO_000068: ncbigene

position:403580:-1
position: 403580
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:403879:-1
position: 403879
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:403580-403879:-1:exon

YKL018C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCO12
locus tag: YKL018C-A
product: Mco12p
transcript id: NM_001184481.1
SIO_010081: YKL018C-A
subclass of: SO_0000673
so part of: YKL018C-A
location: complement(<403580..>403879)
location: region:403580-403879:-1
so has part: feature:403580-403879:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:403580-403879:-1:exon

YKL018C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCO12
locus tag: YKL018C-A
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative mitochondrial hypothetical protein; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: Mco12p
translation: MLGMIRWVVEGTLVAMLLSAIRRETGMIFFYNQYQLGGWIHRYLSWGEMCYTRTLKMVKRSKFFRKQLNEDGFGRINDSGPKRRGRDQSQYSSRFVELD
SIO_010081: YKL018C-A
subclass of: SO_0000673
so part of: YKL018C-A
location: complement(403580..403879)
location: region:403580-403879:-1
so has part: feature:403580-403879:-1:exon

NP_076899.1
type: Protein
SIO_000068: ncbiprotein

S000007615
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:403580-403879:-1:exon

YKL018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPS35
alternative label: SAF37
gene: SWD2
locus tag: YKL018W
gene synonym: CPS35; SAF37
so part of: sequence
location: <404102..>405091
location: region:404102-405091:1
so has part: feature:404102-405091:1:exon
subclass of: SO_0000010

853851
type: Gene
SIO_000068: ncbigene

position:404102:1
position: 404102
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:405091:1
position: 405091
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:404102-405091:1:exon

YKL018W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPS35
alternative label: SAF37
gene: SWD2
locus tag: YKL018W
gene synonym: CPS35; SAF37
product: WD-repeat containing protein SWD2
transcript id: NM_001179584.3
SIO_010081: YKL018W
subclass of: SO_0000673
so part of: YKL018W
location: <404102..>405091
location: region:404102-405091:1
so has part: feature:404102-405091:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:404102-405091:1:exon

YKL018W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPS35
alternative label: SAF37
gene: SWD2
locus tag: YKL018W
gene synonym: CPS35; SAF37
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]
experiment: EXISTENCE:direct assay:GO:0051568 histone H3-K4 methylation [PMID:11742990|PMID:11752412|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:15146080]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15146080]
experiment: EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:15146080]
experiment: EXISTENCE:mutant phenotype:GO:0034729 histone H3-K79 methylation [PMID:18083099]
experiment: EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11742990|PMID:11752412]
note: Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
codon start: 1
product: WD-repeat containing protein SWD2
translation: MTTVSINKPNLLKFKHVKSFQPQEKDCGPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFTHAQNECIYSSTMKNFDIKYLNLETNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLKISKPQVIIPSLVPNCIAYDPSGLVFALGNPENFEIGLYNLKKIQEGPFLIIKINDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIGTRAFPMREFLDSGSACFTPDGEFVLGTDYDGRIAIWNHSDSISNKVLRPQGFIPCVSHETCPRSIAFNPKYSMFVTADETVDFYVYDE
SIO_010081: YKL018W
subclass of: SO_0000673
so part of: YKL018W
location: 404102..405091
location: region:404102-405091:1
so has part: feature:404102-405091:1:exon

NP_012907.3
type: Protein
SIO_000068: ncbiprotein

S000001501
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:404102-405091:1:exon

YKL017C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DIP1
gene: HCS1
locus tag: YKL017C
gene synonym: DIP1
so part of: sequence
location: complement(<405190..>407241)
location: region:405190-407241:-1
so has part: feature:405190-407241:-1:exon
subclass of: SO_0000010

853852
type: Gene
SIO_000068: ncbigene

position:405190:-1
position: 405190
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:407241:-1
position: 407241
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405190-407241:-1:exon

YKL017C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DIP1
gene: HCS1
locus tag: YKL017C
gene synonym: DIP1
product: ATP-dependent 5'-3' DNA helicase HCS1
transcript id: NM_001179583.1
SIO_010081: YKL017C
subclass of: SO_0000673
so part of: YKL017C
location: complement(<405190..>407241)
location: region:405190-407241:-1
so has part: feature:405190-407241:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:405190-407241:-1:exon

YKL017C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DIP1
gene: HCS1
locus tag: YKL017C
gene synonym: DIP1
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0033203 DNA helicase A complex [PMID:9341218]
experiment: EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:9341218|PMID:8257676]
experiment: EXISTENCE:direct assay:GO:0043601 nuclear replisome [PMID:8257676]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:20463880]
experiment: EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:20463880]
note: Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
codon start: 1
product: ATP-dependent 5'-3' DNA helicase HCS1
translation: MNKELASKFLSSIKHEREQDIQTTSRLLTTLSIQQLVQNGLAINNIHLENIRSGLIGKLYMELGPNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTKPKVKKVSEDSNGEQAECSGVVYKMSDTQITIALEESQDVIATTFYSYSKLYILKTTNVVTYNRMESTMRKLSEISSPIQDKIIQYLVNERPFIPNTNSFQNIKSFLNPNLNDSQKTAINFAINNDLTIIHGPPGTGKTFTLIELIQQLLIKNPEERILICGPSNISVDTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKLIQENKKLKNYKQRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYRDDPNFQLFDTLIIDEVSQAMEPQCWIPLIAHQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNLETTLFDRIIKIFPKRDMVKFLNVQYRMNQKIMEFPSHSMYNGKLLADATVANRLLIDLPTVDATPSEDDDDTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKKLIHDELKLTDIEISTVDGFQGREKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQRCGNKYLKSWSEWCEENADVRYPNIDDYL
SIO_010081: YKL017C
subclass of: SO_0000673
so part of: YKL017C
location: complement(405190..407241)
location: region:405190-407241:-1
so has part: feature:405190-407241:-1:exon

NP_012908.1
type: Protein
SIO_000068: ncbiprotein

S000001500
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:405190-407241:-1:exon

YKL016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATP7
locus tag: YKL016C
so part of: sequence
location: complement(<407465..>407989)
location: region:407465-407989:-1
so has part: feature:407465-407989:-1:exon
subclass of: SO_0000010

853853
type: Gene
SIO_000068: ncbigene

position:407465:-1
position: 407465
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:407989:-1
position: 407989
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407465-407989:-1:exon

YKL016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATP7
locus tag: YKL016C
product: F1F0 ATP synthase subunit d
transcript id: NM_001179582.3
SIO_010081: YKL016C
subclass of: SO_0000673
so part of: YKL016C
location: complement(<407465..>407989)
location: region:407465-407989:-1
so has part: feature:407465-407989:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407465-407989:-1:exon

YKL016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATP7
locus tag: YKL016C
experiment: EXISTENCE:direct assay:GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk [PMID:18937496]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]
experiment: EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]
experiment: EXISTENCE:mutant phenotype:GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk [PMID:1832157]
experiment: EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:1832157]
experiment: EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:1832157]
note: Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis
codon start: 1
product: F1F0 ATP synthase subunit d
translation: MSLAKSAANKLDWAKVISSLRITGSTATQLSSFKKRNDEARRQLLELQSQPTEVDFSHYRSVLKNTSVIDKIESYVKQYKPVKIDASKQLQVIESFEKHAMTNAKETESLVSKELKDLQSTLDNIQSARPFDELTVDDLTKIKPEIDAKVEEMVKKGKWDVPGYKDRFGNLNVM
SIO_010081: YKL016C
subclass of: SO_0000673
so part of: YKL016C
location: complement(407465..407989)
location: region:407465-407989:-1
so has part: feature:407465-407989:-1:exon

NP_012909.3
type: Protein
SIO_000068: ncbiprotein

S000001499
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407465-407989:-1:exon

YKL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUT3
locus tag: YKL015W
so part of: sequence
location: <408544..>411483
location: region:408544-411483:1
so has part: feature:408544-411483:1:exon
subclass of: SO_0000010

853854
type: Gene
SIO_000068: ncbigene

position:408544:1
position: 408544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:411483:1
position: 411483
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:408544-411483:1:exon

YKL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUT3
locus tag: YKL015W
product: Put3p
transcript id: NM_001179581.1
SIO_010081: YKL015W
subclass of: SO_0000673
so part of: YKL015W
location: <408544..>411483
location: region:408544-411483:1
so has part: feature:408544-411483:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:408544-411483:1:exon

YKL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUT3
locus tag: YKL015W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:1986247]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1986247|PMID:8846888]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:22579222]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8846888]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2689862|PMID:8846888]
experiment: EXISTENCE:mutant phenotype:GO:2001158 positive regulation of proline catabolic process to glutamate [PMID:2689862]
note: Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
codon start: 1
product: Put3p
translation: MVTDQGSRHSIQSKQPAYVNKQPQKRQQRSSVACLSCRKRHIKCPGGNPCQKCVTSNAICEYLEPSKKIVVSTKYLQQLQKDLNDKTEENNRLKALLLERPVSVRGKDNSDDDERHINNAPSSDTLEVSSAPAAPIFDLMSNSNTASDNDNDDDNSNRITNNRSYDHSLEKYYKKAISIFKQPANANGENGNGANGHEDDDEDDEEISTNFAQRSGRLIESHNGFHYFVGSSSMTLFGLEIQSLVTKYISVKNFRPLPINTKNKILNSNLNPAISSFINSNNYLFSSYNFLNPISTIVNLNSINDNLSPLMFKIILKSDTDGSSGQEEVIQFQLPSYNYTKLLIDCFINYNDGCFYFFNEGLVKCGINKLYLENKWLYYDNTKKALDNENDPILQAVWFCKILLILAVGEMYLGSINNEMLKNYSNQPKLPGSKFFQMGSKIFNCLFSSERLENVTKKGGIEVLLLYAFFLQVADYTLASYFYFGQALRTCLILGLHVDSQSDTLSRYEIEHHRRLWWTVYMFERMLSSKAGLPLSFTDYTISTALPADIDDETIEEKNSHYVFRKAELISNCVTIVKINAQILSKLYQRQPETNIIITLKVVIKQLLEWRNNLSDSLQVDFTQKDEDFKISRLSTNMFTEYFQGINLAVRPLLFHFASIQLKRFKTSNTFVNLQNYSATISSLLTCSLHASVNTIRSLWSLLQNSMLAMFSYMDREYLFTSSCTLLLFNTAFGIHEQTLYHLDHSLEIFTQMRNLGNIPAGLRRAQLLTLMANLDFHGIMNDLITKYNDILKFDSMNCENDNIVEDSNEPKRETEKCKPHKDGDRIDPSIIDCDKSNTNTNMIKNESISNIVSILPEGAKPTLTDYSNGNNDVNDINVNNSEPSTFFDIITASLENSYQTTLTEKGSQVMEKNMDQLDSVHNLNDDDLQQLLEDLGNIDHSDEKLWKEITDQAMWLGNTMDPTAAAGSEIDFTDYLGP
SIO_010081: YKL015W
subclass of: SO_0000673
so part of: YKL015W
location: 408544..411483
location: region:408544-411483:1
so has part: feature:408544-411483:1:exon

NP_012910.1
type: Protein
SIO_000068: ncbiprotein

S000001498
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:408544-411483:1:exon

YKL014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NPA1
gene: URB1
locus tag: YKL014C
gene synonym: NPA1
so part of: sequence
location: complement(<411619..>416913)
location: region:411619-416913:-1
so has part: feature:411619-416913:-1:exon
subclass of: SO_0000010

853855
type: Gene
SIO_000068: ncbigene

position:411619:-1
position: 411619
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416913:-1
position: 416913
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411619-416913:-1:exon

YKL014C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NPA1
gene: URB1
locus tag: YKL014C
gene synonym: NPA1
product: Urb1p
transcript id: NM_001179580.3
SIO_010081: YKL014C
subclass of: SO_0000673
so part of: YKL014C
location: complement(<411619..>416913)
location: region:411619-416913:-1
so has part: feature:411619-416913:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:411619-416913:-1:exon

YKL014C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NPA1
gene: URB1
locus tag: YKL014C
gene synonym: NPA1
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15208443|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15208443]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15208443]
note: Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
codon start: 1
product: Urb1p
translation: MSNHSEAYGSRDQRREKYTQGKEFEDGTLETLESIISAVEDETLSKDYQPLIVFFQRGFGAQLVQTWSYYAQVNNHGKFSKTTSLLTKTLRVLSSDTSTVTIGSGLIRLILTDYTKVLYRGLNNMRAQLTNPILRLLKQIVNFNNGQHIEELVSYFDFSLPILPRLLVPSKSELANGNSSADSSKHDSLRFTFIKFWLTLISNASPFVRKELLTENFKIMSNLFKFMNKADSDKLSEHILSVFINDILKEKSFKRTTKTKILNELAASKIHHFYYSSNKNLVKKANEFFLTFGASRDFSVAFPDNCVWFKNSVADGASHGAPITVNQVEFQIHNKLLFNTLRLFKPWEDTLQLGTLIKILENVPELVAPYSIFLTTNGNYDPKMTSYWFGITLLINKIINLKIPQFMEKVDSNIPPATSLVIENILPSLLTKSSLVKSLQFETPIIRQLACQSIVLALKKLEKVSTFYDQKGWRNEKTILLNEFHTRIPDLPIFVSTLSNSLASNKDNRILPLSISIIFNYYSKMFPNLFSINLPSSNIYTDIMQKSKISGIEFAILDNYLQFQEFNSTQTRWWNPSSGGNSLFTLLLKLASSKNASNVITTRISNLLDELTRTNVIFNISLISPVMALVNSLQGLSLQVSEIDNMEQVWKWFDETISRVVKTPYKYVDMAKEYNYISPFIMCLSEQWKYVDKSGNPEFLIKWLILFLRNMIFIGEDHIGIDKLVKNVFPEVSDHDVNIYLKLDSFEENIKKTNSSNSLISSMKSSSFFQYISALPSKNLMNISRLPVNKLDAAGILFRVQLLVEDDSVVYDNWFEATACELTGKIASYMVTDTEFPIIKVLERYINFALPKLAIEKRNALLMKKSRFMCNLIGAVCFETGHQLVEFREIIQKVVFSGENVEEYANYNELYQKEDVNAFLTSVSEYLSTSALTSLLMCSTKLESTRNILQKLFNEGKTIKISLVKNILNKAANEDPASIKEVNISLAKFFEENKVCVDASSDPMGKLSLSETTSLINSFVSSDLNYLVLKAFYRWEHFSFPSFIPSIWRIKDSPLLSIVTTAALFKHMQDKDFSAFAHETISKYGNEIAKSTYTTSKSEIFDEILNMITTYIDFYDETKRNEILKCVLSQSDHKYHAATVRYIAAHNNFTYPGVETWLHKTLLYLTKYLSERKVISNSFFELLRAMAELLKLEEVPNKLNVKIINSQLEAILGSEWIKQIKVLEYVIVLIFCVSKKSIQSQRMVQLLLSNDSYSSIMIKDNDEDSSYRKFLSTMILFSLFSIDPVVNSTPIVQEKLLTFYSGTISSNDKLILKILETIESHTATSWTNMIFSWEFIKDEEEEILEAIGDTRLITKEREGLILTLQKNMIKKSIDRYVLERPQVPELYTDSNTNNYDATTRCDLVKKYYDDTERSGVDMYDPLFLLLLIIHNKELVKMVKDDEGNVTYRYEFENFLDCKIFQFIICSLSDCHTVANISYEHLSNLASSLEKKTAQMNLEKQITSKDNERKESDSDLIKYNSIYQVLIKRILYQRQQNQDPINPLIWFSISRIVDLLGSPTAPLHEKAYRWVLSNSTIRSWDIPMVSDVMMSYNKRQQDDNKKEIDMEIYYGELSWVLTTICKGIKTDEDYKMLEKKGVFEWLLNLINMPYLKERLRELIYFIFYKVQRVADDGGLNLISRNGIVSFFEVLNNNIKSRLPQDDILNNIGTLRNENRGTLNTTLRLAQEQNGIEKLLLGYNELVKSQKRLILWTEGDSDNVVKRLRK
SIO_010081: YKL014C
subclass of: SO_0000673
so part of: YKL014C
location: complement(411619..416913)
location: region:411619-416913:-1
so has part: feature:411619-416913:-1:exon

NP_012911.3
type: Protein
SIO_000068: ncbiprotein

S000001497
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411619-416913:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1113; Autonomously Replicating Sequence
so part of: sequence
location: 417185..417417
location: region:417185-417417:1
so has part: feature:417185-417417:1:region

S000118405
type: SGD
SIO_000068: sgd

position:417185:1
position: 417185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:417417:1
position: 417417
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417185-417417:1:region

YKL013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARC19
locus tag: YKL013C
so part of: sequence
location: complement(<417508..>418023)
location: region:417508-418023:-1
so has part: feature:417508-418023:-1:exon
subclass of: SO_0000010

853856
type: Gene
SIO_000068: ncbigene

position:417508:-1
position: 417508
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:418023:-1
position: 418023
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417508-418023:-1:exon

YKL013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARC19
locus tag: YKL013C
product: Arc19p
transcript id: NM_001179579.1
SIO_010081: YKL013C
subclass of: SO_0000673
so part of: YKL013C
location: complement(<417508..>418023)
location: region:417508-418023:-1
so has part: feature:417508-418023:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417508-418023:-1:exon

YKL013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARC19
locus tag: YKL013C
experiment: EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407|PMID:9210376]
experiment: EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:10377407]
note: Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4
codon start: 1
product: Arc19p
translation: MSQSLRPYLTAVRYSLEAALTLSNFSSQEVERHNRPEVEVPNTSAELLLQPMHISRNENEQVLIEPSVNSVRMSLMVKQADEIEQILVHKFTRFLEQRAEAFYILRRVPIPGYSISFLITNKHTESMKTGKLVDFIIEFMEDVDKEISEIKLFLNARARFVAEAYLDEFVY
SIO_010081: YKL013C
subclass of: SO_0000673
so part of: YKL013C
location: complement(417508..418023)
location: region:417508-418023:-1
so has part: feature:417508-418023:-1:exon

NP_012912.1
type: Protein
SIO_000068: ncbiprotein

S000001496
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417508-418023:-1:exon

YKL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP40
locus tag: YKL012W
so part of: sequence
location: <418310..>420061
location: region:418310-420061:1
so has part: feature:418310-420061:1:exon
subclass of: SO_0000010

853857
type: Gene
SIO_000068: ncbigene

position:418310:1
position: 418310
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420061:1
position: 420061
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:418310-420061:1:exon

YKL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP40
locus tag: YKL012W
product: Prp40p
transcript id: NM_001179578.3
SIO_010081: YKL012W
subclass of: SO_0000673
so part of: YKL012W
location: <418310..>420061
location: region:418310-420061:1
so has part: feature:418310-420061:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:418310-420061:1:exon

YKL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP40
locus tag: YKL012W
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8622699]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8622699]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:15020406]
note: U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex
codon start: 1
product: Prp40p
translation: MSIWKEAKDASGRIYYYNTLTKKSTWEKPKELISQEELLLRENGWKAAKTADGKVYYYNPTTRETSWTIPAFEKKVEPIAEQKHDTVSHAQVNGNRIALTAGEKQEPGRTINEEESQYANNSKLLNVRRRTKEEAEKEFITMLKENQVDSTWSFSRIISELGTRDPRYWMVDDDPLWKKEMFEKYLSNRSADQLLKEHNETSKFKEAFQKMLQNNSHIKYYTRWPTAKRLIADEPIYKHSVVNEKTKRQTFQDYIDTLIDTQKESKKKLKTQALKELREYLNGIITTSSSETFITWQQLLNHYVFDKSKRYMANRHFKVLTHEDVLNEYLKIVNTIENDLQNKLNELRLRNYTRDRIARDNFKSLLREVPIKIKANTRWSDIYPHIKSDPRFLHMLGRNGSSCLDLFLDFVDEQRMYIFAQRSIAQQTLIDQNFEWNDADSDEITKQNIEKVLENDRKFDKVDKEDISLIVDGLIKQRNEKIQQKLQNERRILEQKKHYFWLLLQRTYTKTGKPKPSTWDLASKELGESLEYKALGDEDNIRRQIFEDFKPESSAPTAESATANLTLTASKKRHLTPAVELDY
SIO_010081: YKL012W
subclass of: SO_0000673
so part of: YKL012W
location: 418310..420061
location: region:418310-420061:1
so has part: feature:418310-420061:1:exon

NP_012913.3
type: Protein
SIO_000068: ncbiprotein

S000001495
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:418310-420061:1:exon

YKL011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MGT1
gene: CCE1
locus tag: YKL011C
gene synonym: MGT1
so part of: sequence
location: complement(<420155..>421216)
location: region:420155-421216:-1
so has part: feature:420155-421216:-1:exon
subclass of: SO_0000010

853858
type: Gene
SIO_000068: ncbigene

position:420155:-1
position: 420155
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:421216:-1
position: 421216
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:420155-421216:-1:exon

YKL011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MGT1
gene: CCE1
locus tag: YKL011C
gene synonym: MGT1
product: cruciform cutting endonuclease
transcript id: NM_001179577.1
SIO_010081: YKL011C
subclass of: SO_0000673
so part of: YKL011C
location: complement(<420155..>421216)
location: region:420155-421216:-1
so has part: feature:420155-421216:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:420155-421216:-1:exon

YKL011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MGT1
gene: CCE1
locus tag: YKL011C
gene synonym: MGT1
EC number: 3.1.21.10
experiment: EXISTENCE:direct assay:GO:0004520 endodeoxyribonuclease activity [PMID:8413191]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8413191]
experiment: EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:12198175]
note: Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication
codon start: 1
product: cruciform cutting endonuclease
translation: MSTAQKAKILQLIDSCCQNAKSTQLKSLSFVIGAVNGTTKEAKRTYIQEQCEFLEKLRQQKIREGRINILSMDAGVSNFAFSKMQLLNNDPLPKVLDWQKINLEEKFFQNLKKLSLNPAETSELVFNLTEYLFESMPIPDMFTIERQRTRTMSSRHILDPILKVNILEQILFSNLENKMKYTNKIPNTSKLRYMVCSSDPHRMTSYWCIPREETPTSSKKLKSNKHSKDSRIKLVKKILSTSILEGNSTSSTKLVEFIGVWNNRIRNALTKKKSFKLCDILEIQDNSGVRKDDDLADSFLHCLSWMEWLKNYESITELLNSKTLVKTQFGQVFEFCENKVQKLKFLQNTYNND
SIO_010081: YKL011C
subclass of: SO_0000673
so part of: YKL011C
location: complement(420155..421216)
location: region:420155-421216:-1
so has part: feature:420155-421216:-1:exon

NP_012914.1
type: Protein
SIO_000068: ncbiprotein

S000001494
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:420155-421216:-1:exon

YKL010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UFD4
locus tag: YKL010C
so part of: sequence
location: complement(<421424..>425875)
location: region:421424-425875:-1
so has part: feature:421424-425875:-1:exon
subclass of: SO_0000010

853859
type: Gene
SIO_000068: ncbigene

position:421424:-1
position: 421424
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:425875:-1
position: 425875
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:421424-425875:-1:exon

YKL010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UFD4
locus tag: YKL010C
product: putative ubiquitin-protein ligase UFD4
transcript id: NM_001179576.3
SIO_010081: YKL010C
subclass of: SO_0000673
so part of: YKL010C
location: complement(<421424..>425875)
location: region:421424-425875:-1
so has part: feature:421424-425875:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:421424-425875:-1:exon

YKL010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UFD4
locus tag: YKL010C
EC number: 2.3.2.26
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0035519 protein K29-linked ubiquitination [PMID:28165462]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:10089879]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10089879]
experiment: EXISTENCE:mutant phenotype:GO:0010994 free ubiquitin chain polymerization [PMID:22497224]
experiment: EXISTENCE:mutant phenotype:GO:0051974 negative regulation of telomerase activity [PMID:26365526]
experiment: EXISTENCE:physical interaction:GO:1904855 proteasome regulatory particle binding [PMID:10688918|PMID:12447385]
note: Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; involved in K29-linked ubiquitin-dependent protein catabolism, including ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: putative ubiquitin-protein ligase UFD4
translation: MSENNSHNLDEHESHSENSDYMMDTQVEDDYDEDGHVQGEYSYYPDEDEDEHMLSSVGSFEADDGEDDDNDYHHEDDSGLLYGYHRTQNGSDEDRNEEEDGLERSHDNNEFGSNPLHLPDILETFAQRLEQRRQTSEGLGQHPVGRTLPEILSMIGGRMERSAESSARNERISKLIENTGNASEDPYIAMESLKELSENILMMNQMVVDRIIPMETLIGNIAAILSDKILREELELQMQACRCMYNLFEVCPESISIAVDEHVIPILQGKLVEISYIDLAEQVLETVEYISRVHGRDILKTGQLSIYVQFFDFLTIHAQRKAIAIVSNACSSIRTDDFKTIVEVLPTLKPIFSNATDQPILTRLVNAMYGICGALHGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVDMATRSFQHYSKSPNAGLHETLIYVPNSLLISISRFIVVLFPPEDERILSADKYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAINDQLIKLIGSILAQKETASNANGTYSSEAGTLLVGGLSLLDLICKKFSELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEEYDYEFTDMEIPDSVKPKKISIHIFRTLSLAYIKNKGVNLVNRVLSQMNVEQEAITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFTSTGLASSITKRITSSTVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGVSSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTSSSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFCKSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLSAKLARQLDEPLVVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKSKGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDVLEIEYQEEAGTGLGPTLEFYSVVSKYFARKSLNMWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIELFGYLGTFVARSLLDNRILDFRFSKVFFELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFTVPGNDDIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGAGAFLLS
SIO_010081: YKL010C
subclass of: SO_0000673
so part of: YKL010C
location: complement(421424..425875)
location: region:421424-425875:-1
so has part: feature:421424-425875:-1:exon

NP_012915.3
type: Protein
SIO_000068: ncbiprotein

S000001493
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:421424-425875:-1:exon

YKL009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRT4
locus tag: YKL009W
so part of: sequence
location: <426242..>426952
location: region:426242-426952:1
so has part: feature:426242-426952:1:exon
subclass of: SO_0000010

853860
type: Gene
SIO_000068: ncbigene

position:426242:1
position: 426242
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426952:1
position: 426952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:426242-426952:1:exon

YKL009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRT4
locus tag: YKL009W
product: Mrt4p
transcript id: NM_001179575.1
SIO_010081: YKL009W
subclass of: SO_0000673
so part of: YKL009W
location: <426242..>426952
location: region:426242-426952:1
so has part: feature:426242-426952:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:426242-426952:1:exon

YKL009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRT4
locus tag: YKL009W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:19797079]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19797078|PMID:19797079|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10471698]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
note: Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus
codon start: 1
product: Mrt4p
translation: MPRSKRSKLVTLAQTDKKGRENKERIFDEVREALDTYRYVWVLHLDDVRTPVLQEIRTSWAGSKLIMGKRKVLQKALGEKREEEYKENLYQLSKLCSGVTGLLFTDEDVNTVKEYFKSYVRSDYSRPNTKAPLTFTIPEGIVYSRGGQIPAEEDVPMIHSLEPTMRNKFEIPTKIKAGKITIDSPYLVCTEGEKLDVRQALILKQFGIAASEFKVKVSAYYDNDSSTVESTNINME
SIO_010081: YKL009W
subclass of: SO_0000673
so part of: YKL009W
location: 426242..426952
location: region:426242-426952:1
so has part: feature:426242-426952:1:exon

NP_012916.1
type: Protein
SIO_000068: ncbiprotein

S000001492
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:426242-426952:1:exon

YKL008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DGT1
gene: LAC1
locus tag: YKL008C
gene synonym: DGT1
so part of: sequence
location: complement(<427295..>428551)
location: region:427295-428551:-1
so has part: feature:427295-428551:-1:exon
subclass of: SO_0000010

853861
type: Gene
SIO_000068: ncbigene

position:427295:-1
position: 427295
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:428551:-1
position: 428551
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427295-428551:-1:exon

YKL008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DGT1
gene: LAC1
locus tag: YKL008C
gene synonym: DGT1
product: sphingosine N-acyltransferase LAC1
transcript id: NM_001179574.3
SIO_010081: YKL008C
subclass of: SO_0000673
so part of: YKL008C
location: complement(<427295..>428551)
location: region:427295-428551:-1
so has part: feature:427295-428551:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427295-428551:-1:exon

YKL008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DGT1
gene: LAC1
locus tag: YKL008C
gene synonym: DGT1
EC number: 2.3.1.297
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10198056]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0046513 ceramide biosynthetic process [PMID:15692566]
experiment: EXISTENCE:direct assay:GO:0050291 sphingosine N-acyltransferase activity [PMID:15692566]
experiment: EXISTENCE:direct assay:GO:0061576 acyl-CoA ceramide synthase complex [PMID:15692566]
experiment: EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:11694577]
experiment: EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:11387200|PMID:11694577]
note: Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication
codon start: 1
product: sphingosine N-acyltransferase LAC1
translation: MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI
SIO_010081: YKL008C
subclass of: SO_0000673
so part of: YKL008C
location: complement(427295..428551)
location: region:427295-428551:-1
so has part: feature:427295-428551:-1:exon

NP_012917.3
type: Protein
SIO_000068: ncbiprotein

S000001491
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427295-428551:-1:exon

YKL007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAP1
locus tag: YKL007W
so part of: sequence
location: <429302..>430108
location: region:429302-430108:1
so has part: feature:429302-430108:1:exon
subclass of: SO_0000010

853862
type: Gene
SIO_000068: ncbigene

position:429302:1
position: 429302
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:430108:1
position: 430108
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:429302-430108:1:exon

YKL007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAP1
locus tag: YKL007W
product: Cap1p
transcript id: NM_001179573.1
SIO_010081: YKL007W
subclass of: SO_0000673
so part of: YKL007W
location: <429302..>430108
location: region:429302-430108:1
so has part: feature:429302-430108:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:429302-430108:1:exon

YKL007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAP1
locus tag: YKL007W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:1315784]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:1315784|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0008290 F-actin capping protein complex [PMID:14769858]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:14769858]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:14769858|PMID:1315784]
experiment: EXISTENCE:mutant phenotype:GO:0008290 F-actin capping protein complex [PMID:14769858]
experiment: EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:14769858]
note: Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
codon start: 1
product: Cap1p
translation: MSSSKFEEVINKIINDSPPGELREVYDDLIKITSENSKNTILDAIENYNVQNCIPIEVNGNSVIISKYNKEGAKFFDPVNSVIFSVNHLERKGLDIEPYEFTHAKIEKGQLKELHDKLHEYLLQSFPGDVSFAVYPVPEEISKISIIIVSTKYNPNNFWNGHWRSSYIYDLETRELSGQISTQVHYYEDGNVSFQSGKDINQSNVDDVVCTIRDIETNFENDLDLSFFDLNEKQFKALRRRLPVTRSKINWGSAIGSYRLGKNAAEGK
SIO_010081: YKL007W
subclass of: SO_0000673
so part of: YKL007W
location: 429302..430108
location: region:429302-430108:1
so has part: feature:429302-430108:1:exon

NP_012918.1
type: Protein
SIO_000068: ncbiprotein

S000001490
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:429302-430108:1:exon

YKL006C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SFT1
locus tag: YKL006C-A
so part of: sequence
location: complement(<430198..>430632)
location: region:430198-430632:-1
so has part: feature:430198-430632:-1:exon
subclass of: SO_0000010

853863
type: Gene
SIO_000068: ncbigene

position:430198:-1
position: 430198
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:430632:-1
position: 430632
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:430198-430632:-1:exon

YKL006C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SFT1
locus tag: YKL006C-A
product: Sft1p
transcript id: NM_001180028.3
SIO_010081: YKL006C-A
subclass of: SO_0000673
so part of: YKL006C-A
location: complement(join(<430198..430455,430597..>430632))
location: region:430198-430632:-1
so has part: feature:430597-430632:-1:exon
so has part: feature:430198-430455:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:430597-430632:-1:exon

position:430597:-1
position: 430597
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:430198-430455:-1:exon

position:430455:-1
position: 430455
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YKL006C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SFT1
locus tag: YKL006C-A
experiment: EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:7596416]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:10591633|PMID:7596416]
note: Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment
codon start: 1
product: Sft1p
translation: MSNSRYSQTESNNDRKLEGLANKLATFRNINQEIGDRAVSDSSVINQMTDSLGSMFTDIKNSSSRLTRSLKAGNSIWRMVGLALLIFFILYTLFKLF
SIO_010081: YKL006C-A
subclass of: SO_0000673
so part of: YKL006C-A
location: complement(join(430198..430455,430597..430632))
location: region:430198-430632:-1
so has part: feature:430597-430632:-1:exon
so has part: feature:430198-430455:-1:exon

NP_012919.3
type: Protein
SIO_000068: ncbiprotein

S000002101
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:430597-430632:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:430198-430455:-1:exon

YNCK0015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR87
locus tag: YNCK0015C
so part of: sequence
location: complement(431030..431138)
location: region:431030-431138:-1
so has part: feature:431030-431138:-1:exon
subclass of: SO_0000578

9164916
type: Gene
SIO_000068: ncbigene

position:431030:-1
position: 431030
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:431138:-1
position: 431138
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431030-431138:-1:exon

YNCK0015C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR87
locus tag: YNCK0015C
product: SNR87
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:16484372]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:16484372]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:16484372]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:16484372]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position A436
transcript id: NR_132202.1
SIO_010081: YNCK0015C
subclass of: SO_0000673
so part of: YNCK0015C
location: complement(431030..431138)
location: region:431030-431138:-1
so has part: feature:431030-431138:-1:exon

S000114301
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431030-431138:-1:exon

YKL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL14A
locus tag: YKL006W
so part of: sequence
location: <431906..>432720
location: region:431906-432720:1
so has part: feature:431906-432720:1:exon
subclass of: SO_0000010

853864
type: Gene
SIO_000068: ncbigene

position:431906:1
position: 431906
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:432720:1
position: 432720
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431906-432720:1:exon

YKL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL14A
locus tag: YKL006W
product: ribosomal 60S subunit protein L14A
transcript id: NM_001179572.1
SIO_010081: YKL006W
subclass of: SO_0000673
so part of: YKL006W
location: join(<431906..432034,432433..>432720)
location: region:431906-432720:1
so has part: feature:431906-432034:1:exon
so has part: feature:432433-432720:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:431906-432034:1:exon

position:432034:1
position: 432034
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:432433-432720:1:exon

position:432433:1
position: 432433
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL14A
locus tag: YKL006W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:29788267]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:29788267]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:29788267]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L14A
translation: MSTDSIVKASNWRLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKAGVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCEKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKRYTVKKALAKA
SIO_010081: YKL006W
subclass of: SO_0000673
so part of: YKL006W
location: join(431906..432034,432433..432720)
location: region:431906-432720:1
so has part: feature:431906-432034:1:exon
so has part: feature:432433-432720:1:exon

NP_012920.1
type: Protein
SIO_000068: ncbiprotein

S000001489
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431906-432034:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:432433-432720:1:exon

YKL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BYE1
locus tag: YKL005C
so part of: sequence
location: complement(<433093..>434877)
location: region:433093-434877:-1
so has part: feature:433093-434877:-1:exon
subclass of: SO_0000010

853865
type: Gene
SIO_000068: ncbigene

position:433093:-1
position: 433093
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:434877:-1
position: 434877
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:433093-434877:-1:exon

YKL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BYE1
locus tag: YKL005C
product: Bye1p
transcript id: NM_001179571.3
SIO_010081: YKL005C
subclass of: SO_0000673
so part of: YKL005C
location: complement(<433093..>434877)
location: region:433093-434877:-1
so has part: feature:433093-434877:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:433093-434877:-1:exon

YKL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BYE1
locus tag: YKL005C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:14704159]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24003114]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]
note: Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit
codon start: 1
product: Bye1p
translation: MSVRTSSRSNKGQNKYIEYLLQEETEAPKKKRTKKKVDSAIEKNKKSDSSQEPRKDTENVRTDEVDEADEGYVRCLCGANNENYDAAEYSHGDMVQCDGCDTWQHIKCMTDGKDTIDGLMSEDSKYYCELCDPSLYAHLETSKEAEVSEDEDYHDDVYKPVNDHDDNDADVFLDEESPRKRKRSPDSAKGIHIKSKQVKKSNGSKKRNKSIDAAKSDTAENEMPTRKDFESEKEHKLRYNAEKMFSTLFSKFIVPETIEAKLYELPDGKDVISISQEFAHNLEEELYKACLNVEFGTLDKIYTEKVRSLYSNLKDKKNLELKAHVVEGKLPLNKLVNMNASELANPDLQEFKEKRDKIILENFIVEVPDKPMYVKTHKGDELIEDIAEPQEDILYSKDSIRLHNIDSIDSDKSKIEQTHAISKEPSPSTIINEESLNCAFLYPGLGLEFTGYLNYIGASQKLRRDIFKEAIGDGKLYVEGRLPTTTAAPYLKEISCSRAILVYQLFPSNDSESKTTFADVVDSLENKGRIAGIKPKTRYEKDFYIVPSKGGEIPEILKDILGSHNDERSERFSRMKSDERTLFAFVVVKQEFIH
SIO_010081: YKL005C
subclass of: SO_0000673
so part of: YKL005C
location: complement(433093..434877)
location: region:433093-434877:-1
so has part: feature:433093-434877:-1:exon

NP_012921.3
type: Protein
SIO_000068: ncbiprotein

S000001488
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:433093-434877:-1:exon

YKL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AUR1
locus tag: YKL004W
so part of: sequence
location: <435580..>436785
location: region:435580-436785:1
so has part: feature:435580-436785:1:exon
subclass of: SO_0000010

853866
type: Gene
SIO_000068: ncbigene

position:435580:1
position: 435580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436785:1
position: 436785
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:435580-436785:1:exon

YKL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AUR1
locus tag: YKL004W
product: inositol phosphorylceramide synthase
transcript id: NM_001179570.1
SIO_010081: YKL004W
subclass of: SO_0000673
so part of: YKL004W
location: <435580..>436785
location: region:435580-436785:1
so has part: feature:435580-436785:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:435580-436785:1:exon

YKL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AUR1
locus tag: YKL004W
EC number: 2.7.1.227
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10888667]
experiment: EXISTENCE:direct assay:GO:0006673 inositol phosphoceramide metabolic process [PMID:19726565]
experiment: EXISTENCE:direct assay:GO:0045140 inositol phosphoceramide synthase activity [PMID:19047657]
experiment: EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9092515]
experiment: EXISTENCE:mutant phenotype:GO:0045140 inositol phosphoceramide synthase activity [PMID:9092515]
experiment: EXISTENCE:physical interaction:GO:0070916 inositol phosphoceramide synthase complex [PMID:19726565]
note: Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase
codon start: 1
product: inositol phosphorylceramide synthase
translation: MANPFSRWFLSERPPNCHVADLETSLDPHQTLLKVQKYKPALSDWVHYIFLGSIMLFVFITNPAPWIFKILFYCFLGTLFIIPATSQFFFNALPILTWVALYFTSSYFPDDRRPPITVKVLPAVETILYGDNLSDILATSTNSFLDILAWLPYGLFHFGAPFVVAAILFVFGPPTVLQGYAFAFGYMNLFGVIMQNVFPAAPPWYKILYGLQSANYDMHGSPGGLARIDKLLGINMYTTAFSNSSVIFGAFPSLHSGCATMEALFFCYCFPKLKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTHLPIVDTSLFCRWSYTSIEKYDISKSDPLAADSNDIESVPLSNLELDFDLNMTDEPSVSPSLFDGSTSVSRSSATSITSLGVKRA
SIO_010081: YKL004W
subclass of: SO_0000673
so part of: YKL004W
location: 435580..436785
location: region:435580-436785:1
so has part: feature:435580-436785:1:exon

NP_012922.1
type: Protein
SIO_000068: ncbiprotein

S000001487
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:435580-436785:1:exon

YKL003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bS6m
gene: MRP17
locus tag: YKL003C
gene synonym: bS6m
so part of: sequence
location: complement(<437097..>437492)
location: region:437097-437492:-1
so has part: feature:437097-437492:-1:exon
subclass of: SO_0000010

853867
type: Gene
SIO_000068: ncbigene

position:437097:-1
position: 437097
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437492:-1
position: 437492
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437097-437492:-1:exon

YKL003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bS6m
gene: MRP17
locus tag: YKL003C
gene synonym: bS6m
product: mitochondrial 37S ribosomal protein YmS16
transcript id: NM_001179569.3
SIO_010081: YKL003C
subclass of: SO_0000673
so part of: YKL003C
location: complement(<437097..>437492)
location: region:437097-437492:-1
so has part: feature:437097-437492:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437097-437492:-1:exon

YKL003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bS6m
gene: MRP17
locus tag: YKL003C
gene synonym: bS6m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]
note: Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
codon start: 1
product: mitochondrial 37S ribosomal protein YmS16
translation: MLYELIGLVRITNSNAPKLEAKELSSTIGKLIIQNRGVVRDIVPMGIRYLPKIMKKDQEKHFRAYHFLMLFDSSAAVQSEILRTLKKDPRVIRSSIVKVDLDKQLDRASSLHRSLGKKSILELVNEDYQSI
SIO_010081: YKL003C
subclass of: SO_0000673
so part of: YKL003C
location: complement(437097..437492)
location: region:437097-437492:-1
so has part: feature:437097-437492:-1:exon

NP_012923.3
type: Protein
SIO_000068: ncbiprotein

S000001486
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437097-437492:-1:exon

YKL002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHM2
alternative label: GRD7
alternative label: REN1
alternative label: VPL2
alternative label: VPS14
alternative label: VPS2
alternative label: VPT14
gene: DID4
locus tag: YKL002W
gene synonym: CHM2; GRD7; REN1; VPL2; VPS14; VPS2; VPT14
so part of: sequence
location: <437778..>438544
location: region:437778-438544:1
so has part: feature:437778-438544:1:exon
subclass of: SO_0000010

853868
type: Gene
SIO_000068: ncbigene

position:437778:1
position: 437778
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:438544:1
position: 438544
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437778-438544:1:exon

YKL002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHM2
alternative label: GRD7
alternative label: REN1
alternative label: VPL2
alternative label: VPS14
alternative label: VPS2
alternative label: VPT14
gene: DID4
locus tag: YKL002W
gene synonym: CHM2; GRD7; REN1; VPL2; VPS14; VPS2; VPT14
product: ESCRT-III subunit protein DID4
transcript id: NM_001179568.1
SIO_010081: YKL002W
subclass of: SO_0000673
so part of: YKL002W
location: join(<437778..437837,437906..>438544)
location: region:437778-438544:1
so has part: feature:437778-437837:1:exon
so has part: feature:437906-438544:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437778-437837:1:exon

position:437837:1
position: 437837
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:437906-438544:1:exon

position:437906:1
position: 437906
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKL002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHM2
alternative label: GRD7
alternative label: REN1
alternative label: VPL2
alternative label: VPS14
alternative label: VPS2
alternative label: VPT14
gene: DID4
locus tag: YKL002W
gene synonym: CHM2; GRD7; REN1; VPL2; VPS14; VPS2; VPT14
experiment: EXISTENCE:curator inference:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15086794]
experiment: EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12194857]
experiment: EXISTENCE:direct assay:GO:0045324 late endosome to vacuole transport [PMID:12194857]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]
experiment: EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
note: Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
codon start: 1
product: ESCRT-III subunit protein DID4
translation: MSLFEWVFGKNVTPQERLKKNQRALERTQRELEREKRKLELQDKKLVSEIKKSAKNGQVAAAKVQAKDLVRTRNYIQKFDNMKAQLQAISLRIQAVRSSDQMTRSMSEATGLLAGMNRTMNLPQLQRISMEFEKQSDLMGQRQEFMDEAIDNVMGDEVDEDEEADEIVNKVLDEIGVDLNSQLQSTPQNLVSNAPIAETAMGIPEPIGAGSEFHGNPDDDLQARLNTLKKQT
SIO_010081: YKL002W
subclass of: SO_0000673
so part of: YKL002W
location: join(437778..437837,437906..438544)
location: region:437778-438544:1
so has part: feature:437778-437837:1:exon
so has part: feature:437906-438544:1:exon

NP_012924.2
type: Protein
SIO_000068: ncbiprotein

S000001485
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437778-437837:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:437906-438544:1:exon

YKL001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MET14
locus tag: YKL001C
so part of: sequence
location: complement(<438777..>439385)
location: region:438777-439385:-1
so has part: feature:438777-439385:-1:exon
subclass of: SO_0000010

853869
type: Gene
SIO_000068: ncbigene

position:438777:-1
position: 438777
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439385:-1
position: 439385
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438777-439385:-1:exon

YKL001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MET14
locus tag: YKL001C
product: adenylyl-sulfate kinase
transcript id: NM_001179567.3
SIO_010081: YKL001C
subclass of: SO_0000673
so part of: YKL001C
location: complement(<438777..>439385)
location: region:438777-439385:-1
so has part: feature:438777-439385:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:438777-439385:-1:exon

YKL001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MET14
locus tag: YKL001C
EC number: 2.7.1.25
experiment: EXISTENCE:direct assay:GO:0004020 adenylylsulfate kinase activity [PMID:3019265]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]
experiment: EXISTENCE:mutant phenotype:GO:0004020 adenylylsulfate kinase activity [PMID:197388]
experiment: EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]
note: Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant
codon start: 1
product: adenylyl-sulfate kinase
translation: MATNITWHPNLTYDERKALRKQDGCTIWLTGLSASGKSTIACALEQLLLQKNLSAYRLDGDNIRFGLNKDLGFSEKDRNENIRRISEVSKLFADSCAISITSFISPYRVDRDRARELHKEAGLKFIEIFVDVPLEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPKAPELHLRTDQKTVEECATIIYEYLISEKIIRKHL
SIO_010081: YKL001C
subclass of: SO_0000673
so part of: YKL001C
location: complement(438777..439385)
location: region:438777-439385:-1
so has part: feature:438777-439385:-1:exon

NP_012925.3
type: Protein
SIO_000068: ncbiprotein

S000001484
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438777-439385:-1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN11; Chromosome XI centromere
so part of: sequence
location: complement(440129..440246)
location: region:440129-440246:-1
so has part: feature:440129-440246:-1:region

S000006472
type: SGD
SIO_000068: sgd

position:440129:-1
position: 440129
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:440246:-1
position: 440246
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440129-440246:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN11_CDEIII of CEN11
so part of: sequence
location: complement(440129..440153)
location: region:440129-440153:-1
so has part: feature:440129-440153:-1:region

position:440153:-1
position: 440153
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440129-440153:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN11_CDEII of CEN11
so part of: sequence
location: complement(440154..440236)
location: region:440154-440236:-1
so has part: feature:440154-440236:-1:region

position:440154:-1
position: 440154
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:440236:-1
position: 440236
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440154-440236:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN11_CDEI of CEN11
so part of: sequence
location: complement(440237..440246)
location: region:440237-440246:-1
so has part: feature:440237-440246:-1:region

position:440237:-1
position: 440237
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440237-440246:-1:region

YKR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GRD1
alternative label: LAM1
alternative label: SPO15
alternative label: VPL1
alternative label: VPT26
gene: VPS1
locus tag: YKR001C
gene synonym: GRD1; LAM1; SPO15; VPL1; VPT26
so part of: sequence
location: complement(<440608..>442722)
location: region:440608-442722:-1
so has part: feature:440608-442722:-1:exon
subclass of: SO_0000010

853870
type: Gene
SIO_000068: ncbigene

position:440608:-1
position: 440608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442722:-1
position: 442722
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440608-442722:-1:exon

YKR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GRD1
alternative label: LAM1
alternative label: SPO15
alternative label: VPL1
alternative label: VPT26
gene: VPS1
locus tag: YKR001C
gene synonym: GRD1; LAM1; SPO15; VPL1; VPT26
product: dynamin-like GTPase VPS1
transcript id: NM_001179791.1
SIO_010081: YKR001C
subclass of: SO_0000673
so part of: YKR001C
location: complement(<440608..>442722)
location: region:440608-442722:-1
so has part: feature:440608-442722:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440608-442722:-1:exon

YKR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GRD1
alternative label: LAM1
alternative label: SPO15
alternative label: VPL1
alternative label: VPT26
gene: VPS1
locus tag: YKR001C
gene synonym: GRD1; LAM1; SPO15; VPL1; VPT26
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15550248]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8299420]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:23385815]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16520372]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0007031 peroxisome organization [PMID:12707309]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:20841380]
experiment: EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:25772449]
experiment: EXISTENCE:direct assay:GO:0060988 lipid tube assembly [PMID:20841380]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:20841380]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8299420]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:20841380|PMID:26478779]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12707309]
experiment: EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:8299420]
experiment: EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:18445678]
experiment: EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:15265985]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]
experiment: EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:25772449|PMID:26478779]
note: Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
codon start: 1
product: dynamin-like GTPase VPS1
translation: MDEHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKKFYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQIKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDILAGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSILLHHIRQTLPEIKAKIEATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKELSSQELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVKQQIRRFEEPSLRLVTLVFDELVRMLKQIISQPKYSRYPALREAISNQFIQFLKDATIPTNEFVVDIIKAEQTYINTAHPDLLKGSQAMVMVEEKLHPRQVAVDPKTGKPLPTQPSSSKAPVMEEKSGFFGGFFSTKNKKKLAALESPPPVLKATGQMTERETMETEVIKLLISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKENDITIQRRKECKKMVEILRNASQIVSSV
SIO_010081: YKR001C
subclass of: SO_0000673
so part of: YKR001C
location: complement(440608..442722)
location: region:440608-442722:-1
so has part: feature:440608-442722:-1:exon

NP_012926.1
type: Protein
SIO_000068: ncbiprotein

S000001709
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440608-442722:-1:exon

YKR002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAP1
locus tag: YKR002W
so part of: sequence
location: <443232..>444938
location: region:443232-444938:1
so has part: feature:443232-444938:1:exon
subclass of: SO_0000010

853871
type: Gene
SIO_000068: ncbigene

position:443232:1
position: 443232
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:444938:1
position: 444938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443232-444938:1:exon

YKR002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAP1
locus tag: YKR002W
product: polynucleotide adenylyltransferase PAP1
transcript id: NM_001179792.3
SIO_010081: YKR002W
subclass of: SO_0000673
so part of: YKR002W
location: <443232..>444938
location: region:443232-444938:1
so has part: feature:443232-444938:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443232-444938:1:exon

YKR002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAP1
locus tag: YKR002W
EC number: 2.7.7.19
experiment: EXISTENCE:direct assay:GO:0004652 polynucleotide adenylyltransferase activity [PMID:1840648]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:1840648]
experiment: EXISTENCE:genetic interaction:GO:0071050 sno(s)RNA polyadenylation [PMID:18951092]
experiment: EXISTENCE:mutant phenotype:GO:0006378 mRNA polyadenylation [PMID:8524265]
note: Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
codon start: 1
product: polynucleotide adenylyltransferase PAP1
translation: MSSQKVFGITGPVSTVGATAAENKLNDSLIQELKKEGSFETEQETANRVQVLKILQELAQRFVYEVSKKKNMSDGMARDAGGKIFTYGSYRLGVHGPGSDIDTLVVVPKHVTREDFFTVFDSLLRERKELDEIAPVPDAFVPIIKIKFSGISIDLICARLDQPQVPLSLTLSDKNLLRNLDEKDLRALNGTRVTDEILELVPKPNVFRIALRAIKLWAQRRAVYANIFGFPGGVAWAMLVARICQLYPNACSAVILNRFFIILSEWNWPQPVILKPIEDGPLQVRVWNPKIYAQDRSHRMPVITPAYPSMCATHNITESTKKVILQEFVRGVQITNDIFSNKKSWANLFEKNDFFFRYKFYLEITAYTRGSDEQHLKWSGLVESKVRLLVMKLEVLAGIKIAHPFTKPFESSYCCPTEDDYEMIQDKYGSHKTETALNALKLVTDENKEEESIKDAPKAYLSTMYIGLDFNIENKKEKVDIHIPCTEFVNLCRSFNEDYGDHKVFNLALRFVKGYDLPDEVFDENEKRPSKKSKRKNLDARHETVKRSKSDAASGDNINGTTAAVDVN
SIO_010081: YKR002W
subclass of: SO_0000673
so part of: YKR002W
location: 443232..444938
location: region:443232-444938:1
so has part: feature:443232-444938:1:exon

NP_012927.3
type: Protein
SIO_000068: ncbiprotein

S000001710
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443232-444938:1:exon

YKR003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSH6
locus tag: YKR003W
so part of: sequence
location: <445381..>446727
location: region:445381-446727:1
so has part: feature:445381-446727:1:exon
subclass of: SO_0000010

853872
type: Gene
SIO_000068: ncbigene

position:445381:1
position: 445381
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:446727:1
position: 446727
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:445381-446727:1:exon

YKR003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSH6
locus tag: YKR003W
product: oxysterol-binding protein OSH6
transcript id: NM_001179793.1
SIO_010081: YKR003W
subclass of: SO_0000673
so part of: YKR003W
location: <445381..>446727
location: region:445381-446727:1
so has part: feature:445381-446727:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:445381-446727:1:exon

YKR003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSH6
locus tag: YKR003W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16096648]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:16156791]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0043325 phosphatidylinositol-3,4-bisphosphate binding [PMID:16156791]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:16156791]
experiment: EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:16156791]
experiment: EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16156791]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29487131]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]
experiment: EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]
experiment: EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]
experiment: EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]
experiment: EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:16156791]
note: Oxysterol-binding phosphatidylserine transferase; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication
codon start: 1
product: oxysterol-binding protein OSH6
translation: MGSKKLTVGSDSHRLSKSSFSSNKSSHSATKDQPIDTDDIDEDDESGHNIILNIISQLRPGCDLTRITLPTFILEKKSMLERVTNQLQFPEFLLQAHSEKDPLKRFLYVMKWYLAGWHIAPKAVKKPLNPVLGEYFTAYWDLPNKQQAYYISEQTSHHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYVLTQPNVYVRGILFGKMRIELGDHMIIKSPNFQADIEFKTKGYVFGTYDAIEGTVKDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESRKLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRRSKPGEDLDYCIYKNIPVDEDPEKQIRSILQIAPILPGQQFTDKFFIPAFEKIKSQKKMIENEKQNPAKQ
SIO_010081: YKR003W
subclass of: SO_0000673
so part of: YKR003W
location: 445381..446727
location: region:445381-446727:1
so has part: feature:445381-446727:1:exon

NP_012928.1
type: Protein
SIO_000068: ncbiprotein

S000001711
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:445381-446727:1:exon

YKR004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKR004C-A
gene: ECM9
locus tag: YKR004C
gene synonym: YKR004C-A
so part of: sequence
location: complement(<446799..>448036)
location: region:446799-448036:-1
so has part: feature:446799-448036:-1:exon
subclass of: SO_0000010

853873
type: Gene
SIO_000068: ncbigene

position:446799:-1
position: 446799
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:448036:-1
position: 448036
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446799-448036:-1:exon

YKR004C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKR004C-A
gene: ECM9
locus tag: YKR004C
gene synonym: YKR004C-A
product: Ecm9p
transcript id: NM_001179794.3
SIO_010081: YKR004C
subclass of: SO_0000673
so part of: YKR004C
location: complement(join(<446799..447706,447811..>448036))
location: region:446799-448036:-1
so has part: feature:447811-448036:-1:exon
so has part: feature:446799-447706:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447811-448036:-1:exon

position:447811:-1
position: 447811
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:446799-447706:-1:exon

position:447706:-1
position: 447706
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YKR004C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKR004C-A
gene: ECM9
locus tag: YKR004C
gene synonym: YKR004C-A
note: Non-essential hypothetical protein
codon start: 1
product: Ecm9p
translation: MQSSLPLCREFFEKITAYLDYHDFRLTITANQPSITLPYYVDEKAHSIELIIFKTTFLSLFQEAHTYFNKTFSDQSGISNENIYYMTVGFLLTTPENKTVYNVHEDLLKRYFQDNSVLVIPDLLVKEVRLIQRLLCSSNNRINKSSSLWILYRKLFVLSLDANTLVLPDILFVFHSSGSQHFSNYYCWNTARWFYDNLPYNKRIELFNLTKRFCFQNVKDCSSWSALAYMVCQQEEKKTDNIRDFQRLTSSFNVPFKINKVDLNFQVQPADAFTQELVKWIDRTYAADWPPYLCLLQITKFNITLRIEMDSVLLTWRNEILNFEENSGHIKMINNTPIVPEKFSNDLLTSVNFAHFGYKKLFLNKFLDKNKKEQSDS
SIO_010081: YKR004C
subclass of: SO_0000673
so part of: YKR004C
location: complement(join(446799..447706,447811..448036))
location: region:446799-448036:-1
so has part: feature:447811-448036:-1:exon
so has part: feature:446799-447706:-1:exon

NP_012929.4
type: Protein
SIO_000068: ncbiprotein

S000001712
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447811-448036:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:446799-447706:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1114; Autonomously Replicating Sequence
so part of: sequence
location: 448020..448254
location: region:448020-448254:1
so has part: feature:448020-448254:1:region

S000118406
type: SGD
SIO_000068: sgd

position:448020:1
position: 448020
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:448254:1
position: 448254
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448020-448254:1:region

YKR005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR005C
so part of: sequence
location: complement(<448521..>450167)
location: region:448521-450167:-1
so has part: feature:448521-450167:-1:exon
subclass of: SO_0000010

853874
type: Gene
SIO_000068: ncbigene

position:448521:-1
position: 448521
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:450167:-1
position: 450167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448521-450167:-1:exon

YKR005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR005C
product: uncharacterized protein
transcript id: NM_001179795.1
SIO_010081: YKR005C
subclass of: SO_0000673
so part of: YKR005C
location: complement(join(<448521..449951,450021..>450167))
location: region:448521-450167:-1
so has part: feature:450021-450167:-1:exon
so has part: feature:448521-449951:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450021-450167:-1:exon

position:450021:-1
position: 450021
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:448521-449951:-1:exon

position:449951:-1
position: 449951
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YKR005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR005C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]
codon start: 1
product: uncharacterized protein
translation: MLECLSALLVLFAGGGGSVLAAVQSKTVADPNLCPGYNSQLISPFLSSCKRNLSECVSRYFDEQYAFCRSCVTVNNETMEDLDNCKCLQCALSSLNNSCFHDYCTSKDEYDKLQIVVEQFQLTNGVLDDGEILKPRGNKFSSRKLSYFVGQNNTLFRNPLQFEKNQLISALLTSLTNNQKTISSVDMFEVVDANNEVQYLRERTISGKTLSPATGYEEENDGDCSVKDKKWEGKIEYHENKKVSSENCSKDTDDKSGSKKERNTKAPLFHTATEIHMTRWSSWRPKKIFTRYLVNEYQSPKIITTVNRFYRTKTDTETGTTLITSTKAKRRWFPRTKIVTSTATSTFLSITTTTTTNAIATKSLVAVLNPDGLNKKAGINFGLFSANGELASPDEGGTPTVVRRDKISDPGAANEQATLFSTTFSQVPHLPELDSGEFISAASQLDKRIFIFTAITVSITTLMMLGFSYRSRVSFRDHSIDDSDDDNDWSDDEVEFDEEYFYSLPVSIPEKGISLDKMAQQLGVE
SIO_010081: YKR005C
subclass of: SO_0000673
so part of: YKR005C
location: complement(join(448521..449951,450021..450167))
location: region:448521-450167:-1
so has part: feature:450021-450167:-1:exon
so has part: feature:448521-449951:-1:exon

NP_012930.2
type: Protein
SIO_000068: ncbiprotein

S000001713
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450021-450167:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:448521-449951:-1:exon

YKR006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL50
alternative label: YK105
gene: MRPL13
locus tag: YKR006C
gene synonym: mL50; YK105
so part of: sequence
location: complement(<450423..>451217)
location: region:450423-451217:-1
so has part: feature:450423-451217:-1:exon
subclass of: SO_0000010

853875
type: Gene
SIO_000068: ncbigene

position:450423:-1
position: 450423
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451217:-1
position: 451217
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450423-451217:-1:exon

YKR006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL50
alternative label: YK105
gene: MRPL13
locus tag: YKR006C
gene synonym: mL50; YK105
product: mitochondrial 54S ribosomal protein YmL13
transcript id: NM_001179796.3
SIO_010081: YKR006C
subclass of: SO_0000673
so part of: YKR006C
location: complement(<450423..>451217)
location: region:450423-451217:-1
so has part: feature:450423-451217:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450423-451217:-1:exon

YKR006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL50
alternative label: YK105
gene: MRPL13
locus tag: YKR006C
gene synonym: mL50; YK105
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]
note: Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation
codon start: 1
product: mitochondrial 54S ribosomal protein YmL13
translation: MSSLLKLHCIRPLPQRSVWLSGYKQKARCIHSSAANGDFMSWFKRKKQEEHQEPVKDTKQLIKDIEEGTNEASSQSSSNNKNRLELIPENFIGEGSRRCKRQKELKLAVSSAPFNQWLSRDKITSDNQLDDMILQATEKTLGKVDQDVQFSDLVAKFQFTKFLQSKSGYLIPDYELTTLSTPLQFKRYIKEKILPSANDPKLAYKEAEPNAIHPFSDNYASPNIYVVNDVTSKEQKSKYDTIMKEIQKLEDDATRKALETARSA
SIO_010081: YKR006C
subclass of: SO_0000673
so part of: YKR006C
location: complement(450423..451217)
location: region:450423-451217:-1
so has part: feature:450423-451217:-1:exon

NP_012931.4
type: Protein
SIO_000068: ncbiprotein

S000001714
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450423-451217:-1:exon

YKR007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EGO1
alternative label: GSE2
gene: MEH1
locus tag: YKR007W
gene synonym: EGO1; GSE2
so part of: sequence
location: <451434..>451988
location: region:451434-451988:1
so has part: feature:451434-451988:1:exon
subclass of: SO_0000010

853876
type: Gene
SIO_000068: ncbigene

position:451434:1
position: 451434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451988:1
position: 451988
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451434-451988:1:exon

YKR007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EGO1
alternative label: GSE2
gene: MEH1
locus tag: YKR007W
gene synonym: EGO1; GSE2
product: Meh1p
transcript id: NM_001179797.1
SIO_010081: YKR007W
subclass of: SO_0000673
so part of: YKR007W
location: <451434..>451988
location: region:451434-451988:1
so has part: feature:451434-451988:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:451434-451988:1:exon

YKR007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EGO1
alternative label: GSE2
gene: MEH1
locus tag: YKR007W
gene synonym: EGO1; GSE2
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15885099|PMID:15989961|PMID:16301533|PMID:19748353|P MID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]
experiment: EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:15885099]
experiment: EXISTENCE:mutant phenotype:GO:0016237 lysosomal microautophagy [PMID:15989961]
experiment: EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:26206314]
experiment: EXISTENCE:physical interaction:GO:0071986 Ragulator complex [PMID:15989961]
note: Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; targeted to vacuole via AP-3 pathway; loss results in defect in vacuolar acidification
codon start: 1
product: Meh1p
translation: MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQELRDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHSVPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPLTVPF
SIO_010081: YKR007W
subclass of: SO_0000673
so part of: YKR007W
location: 451434..451988
location: region:451434-451988:1
so has part: feature:451434-451988:1:exon

NP_012932.1
type: Protein
SIO_000068: ncbiprotein

S000001715
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451434-451988:1:exon

YKR008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSC4
locus tag: YKR008W
so part of: sequence
location: <452201..>454078
location: region:452201-454078:1
so has part: feature:452201-454078:1:exon
subclass of: SO_0000010

853877
type: Gene
SIO_000068: ncbigene

position:452201:1
position: 452201
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454078:1
position: 454078
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:452201-454078:1:exon

YKR008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSC4
locus tag: YKR008W
product: Rsc4p
transcript id: NM_001179798.4
SIO_010081: YKR008W
subclass of: SO_0000673
so part of: YKR008W
location: <452201..>454078
location: region:452201-454078:1
so has part: feature:452201-454078:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:452201-454078:1:exon

YKR008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSC4
locus tag: YKR008W
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12183366|PMID:10619019]
experiment: EXISTENCE:direct assay:GO:0070577 lysine-acetylated histone binding [PMID:20126658]
note: Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
codon start: 1
product: Rsc4p
translation: MVVKKRKLATEAGGSDERPKYLPGKHPKNQEKTPHVDYNAPLNPKSELFLDDWHIPKFNRFISFTLDVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIKSRDYEYEDGPSNFLLDVELLTKNCQAYNEYDSLIVKNSMQVVMLIEFEVLKAKNLKRNYLINSEVKAKLLHYLNKLVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIVHSPMALSIVKQNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLTNYFNYLIQKEFFPELQDLNERGEINLEFDKFEFENYLAIGGGGPAAAGALAISALDNDIEPESNREDLIDQADYDFNHFEGLGNGYNRSLLTEDYLLNPNNFKKLIAKPETVQSEVKNERSTTSDIEKTNSLESEHLKIPKYNVIKSMQKEMQSLSEQHTMEYKPYKLIQQIYIFSSKNLYSQATKPLLGSRPSCNQNWVEYIFNGNELSQNENAFSFMLQPMQTFLTLQSHLTSSLKDTETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVGNDNDKRNNITEIFDIRLSEGLNHLMFRCEDKISHETEFMNFWINVLP
SIO_010081: YKR008W
subclass of: SO_0000673
so part of: YKR008W
location: 452201..454078
location: region:452201-454078:1
so has part: feature:452201-454078:1:exon

NP_012933.4
type: Protein
SIO_000068: ncbiprotein

S000001716
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:452201-454078:1:exon

YKR009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: POX2
gene: FOX2
locus tag: YKR009C
gene synonym: POX2
so part of: sequence
location: complement(<454352..>457054)
location: region:454352-457054:-1
so has part: feature:454352-457054:-1:exon
subclass of: SO_0000010

853878
type: Gene
SIO_000068: ncbigene

position:454352:-1
position: 454352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457054:-1
position: 457054
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454352-457054:-1:exon

YKR009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: POX2
gene: FOX2
locus tag: YKR009C
gene synonym: POX2
product: bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
transcript id: NM_001179799.1
SIO_010081: YKR009C
subclass of: SO_0000673
so part of: YKR009C
location: complement(<454352..>457054)
location: region:454352-457054:-1
so has part: feature:454352-457054:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454352-457054:-1:exon

YKR009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: POX2
gene: FOX2
locus tag: YKR009C
gene synonym: POX2
EC number: 1.1.1.n12
EC number: 4.2.1.119
experiment: EXISTENCE:direct assay:GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity [PMID:1551874]
experiment: EXISTENCE:direct assay:GO:0004300 enoyl-CoA hydratase activity [PMID:1551874]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:30131444]
experiment: EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:10497229|PMID:1551874]
note: 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4
codon start: 1
product: bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
translation: MPGNLSFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVVDVHLTGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLYLTHESTKVSNSIFELAAGFFGQLRWERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYNDLITKAKKLPPNEQGSVKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVIGQLFEVGGGWCGQTRWQRSSGYVSIKETIEPEEIKENWNHITDFSRNTINPSSTEESSMATLQAVQKAHSSKELDDGLFKYTTKDCILYNLGLGCTSKELKYTYENDPDFQVLPTFAVIPFMQATATLAMDNLVDNFNYAMLLHGEQYFKLCTPTMPSNGTLKTLAKPLQVLDKNGKAALVVGGFETYDIKTKKLIAYNEGSFFIRGAHVPPEKEVRDGKRAKFAVQNFEVPHGKVPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKAVKFPTPILHGLCTLGISAKALFEHYGPYEELKVRFTNVVFPGDTLKVKAWKQGSVVVFQTIDTTRNVIVLDNAAVKLSQAKSKL
SIO_010081: YKR009C
subclass of: SO_0000673
so part of: YKR009C
location: complement(454352..457054)
location: region:454352-457054:-1
so has part: feature:454352-457054:-1:exon

NP_012934.1
type: Protein
SIO_000068: ncbiprotein

S000001717
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454352-457054:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(458140..458471)
location: region:458140-458471:-1
so has part: feature:458140-458471:-1:region

S000007058
type: SGD
SIO_000068: sgd

position:458140:-1
position: 458140
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:458471:-1
position: 458471
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458140-458471:-1:region

YNCK0016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0016W
so part of: sequence
location: 458557..458670
location: region:458557-458670:1
so has part: feature:458557-458670:1:exon
subclass of: SO_0000663

853879
type: Gene
SIO_000068: ncbigene

position:458557:1
position: 458557
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:458670:1
position: 458670
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458557-458670:1:exon

YNCK0016W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0016W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0016W
subclass of: SO_0000673
so part of: YNCK0016W
location: join(458557..458594,458627..458670)
location: region:458557-458670:1
so has part: feature:458557-458594:1:exon
so has part: feature:458627-458670:1:exon

S000006642
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458557-458594:1:exon

position:458594:1
position: 458594
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:458627-458670:1:exon

position:458627:1
position: 458627
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKR010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOF2
locus tag: YKR010C
so part of: sequence
location: complement(<458924..>461239)
location: region:458924-461239:-1
so has part: feature:458924-461239:-1:exon
subclass of: SO_0000010

853880
type: Gene
SIO_000068: ncbigene

position:458924:-1
position: 458924
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461239:-1
position: 461239
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458924-461239:-1:exon

YKR010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOF2
locus tag: YKR010C
product: Tof2p
transcript id: NM_001179800.3
SIO_010081: YKR010C
subclass of: SO_0000673
so part of: YKR010C
location: complement(<458924..>461239)
location: region:458924-461239:-1
so has part: feature:458924-461239:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:458924-461239:-1:exon

YKR010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOF2
locus tag: YKR010C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18595708]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0019211 phosphatase activator activity [PMID:18595708]
experiment: EXISTENCE:genetic interaction:GO:0007000 nucleolus organization [PMID:18595708]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:17043313]
experiment: EXISTENCE:mutant phenotype:GO:0007000 nucleolus organization [PMID:18595708]
experiment: EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:18595708|PMID:19362534]
experiment: EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18923139]
note: Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication
codon start: 1
product: Tof2p
translation: MIKMWRLQIVLVPPSAQDIITFLEARLNTPQSVSPMVQYNEDIITHNNSINNCSDPSPTSPSSQNSIQSNRSSDFINYLPNCKKFLHFTDGDNTLLQLSNEILTKFDRLYPNFKESIEIVSLQDRHGCDLDSEFIIKDVFENDGVVLVILKDELDWSRNQHISLLQLARQRRRQDNKPSTKSIVTEKRKKISKEDLSSISNKDTMHLIAKSSLKNNFINKSRVSTPLMNEILPLASKYDALNKEKCPMPLTSTVVASNVHKDVKDHARAKEGVVTQGSDNNKENIPSSTQQQKNDGAKRAESKDLDLLRNSSEDADYEPADENSPQISFDSIDTDFQLSTTSHTNSDMHIQYSNPSSGAHSPRKSSLEIKVQNKKGDDLPLNDKDIGENCRRIEAFSDEEDFNETDNDRADSFINNSKKASMGFRDINSDLDSVSFNSDIENAVQSTQSTKNVVSPPFFPEKELNNRLHQSQGKEALFRLVEKEFPDKSLGAASSTSHAKDVKIQETIRKLNRFKPTGETKVQKRNSITEPYYGKFGIMKKDKPKSITSKGVSLETKHFDDPNTIISGEKFAKFGKIKVKRKTDDVGSKVIEFKRKRNMGNRSLKDIFANAGKPPNAASTIKVVKLMRDPVDNSKDKVEATSNSTAQEQEQVSPKLPVMNSTPGKRKNGQAIPSSLERTPQLKKVKVTRSHSSPSSSSSMSLESSLDSSSSDDSDDDSDSRNVQVKKINFKTSHGPAGNSNGKPMLDVDDNEINTKKYQTPKYVESDEDDQ
SIO_010081: YKR010C
subclass of: SO_0000673
so part of: YKR010C
location: complement(458924..461239)
location: region:458924-461239:-1
so has part: feature:458924-461239:-1:exon

NP_012935.3
type: Protein
SIO_000068: ncbiprotein

S000001718
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458924-461239:-1:exon

YKR011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR011C
so part of: sequence
location: complement(<461635..>462696)
location: region:461635-462696:-1
so has part: feature:461635-462696:-1:exon
subclass of: SO_0000010

853881
type: Gene
SIO_000068: ncbigene

position:461635:-1
position: 461635
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462696:-1
position: 462696
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:461635-462696:-1:exon

YKR011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR011C
product: uncharacterized protein
transcript id: NM_001179801.1
SIO_010081: YKR011C
subclass of: SO_0000673
so part of: YKR011C
location: complement(<461635..>462696)
location: region:461635-462696:-1
so has part: feature:461635-462696:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:461635-462696:-1:exon

YKR011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR011C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MSKLETVYLYAGEEQPRVKLTCIKEGLTLTQVIKFVHSIQELYGIELQTSETITENLKIDCAPAYLKPNCIPHFYILEYEEISDTFFIWKSDGRWQLNKLSALLYVDNDANVVKNTSWKEVFQNDQRFKNYDKRAWLQNCLEKMNRDLSKLNVEQFWSQYDKICQSIAKQKKKQEQFNMEVFDNFKNIVSIAIIKTKVLSNKRLLTTTLKNYHNSMKKKYNIQEQNLKENSLASCSNNEPSASLESESRHFSPVNSLSPSSLSTDDEAVSTDYIYKGPESKPNVNFMHSSATNDLIKSNFESYFKLMAEDYETFDLRAWSRQRPRKFQLVEKKKITKNPPNSHHPHKNGKISF
SIO_010081: YKR011C
subclass of: SO_0000673
so part of: YKR011C
location: complement(461635..462696)
location: region:461635-462696:-1
so has part: feature:461635-462696:-1:exon

NP_012936.1
type: Protein
SIO_000068: ncbiprotein

S000001719
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:461635-462696:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1115; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 462699..463742
location: region:462699-463742:1
so has part: feature:462699-463742:1:region

S000130139
type: SGD
SIO_000068: sgd

position:462699:1
position: 462699
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:463742:1
position: 463742
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462699-463742:1:region

YKR013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YFW12
gene: PRY2
locus tag: YKR013W
gene synonym: YFW12
so part of: sequence
location: <463959..>464948
location: region:463959-464948:1
so has part: feature:463959-464948:1:exon
subclass of: SO_0000010

853882
type: Gene
SIO_000068: ncbigene

position:463959:1
position: 463959
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464948:1
position: 464948
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463959-464948:1:exon

YKR013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YFW12
gene: PRY2
locus tag: YKR013W
gene synonym: YFW12
product: sterol-binding protein
transcript id: NM_001179803.3
SIO_010081: YKR013W
subclass of: SO_0000673
so part of: YKR013W
location: <463959..>464948
location: region:463959-464948:1
so has part: feature:463959-464948:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:463959-464948:1:exon

YKR013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YFW12
gene: PRY2
locus tag: YKR013W
gene synonym: YFW12
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:23027975]
experiment: EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]
experiment: EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:23027975]
experiment: EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]
note: Sterol binding protein involved in the export of acetylated sterols; role in sterol export is redundant with that of PRY1; redundant role with PRY1 and PRY3 in the export of free fatty acids; may be involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)
codon start: 1
product: sterol-binding protein
translation: MKFSKVSLLAASASVALSAPVAVTVTQHVHQAATVVVQGIVRVENGQTLTTFITKGTQTASASPVATTSAPIVVANAQVDSIATSVIQESAVVAESATFEESSTETSEAFSTATATIQAVQTSASATQDDVTTTLTSSTQPTSTTTPTTTTTSPTTTTSPTTTASPTTTASPTTATTTQSTASSTQSSSSDFSTSMVNEHNTKRALHKDTGSLTWSDTLATYAQNYADSYDCSGNLVHSGGPYGENLALGYGTTGSVDAWYNEITSYDYSNPGFSESAGHFTQVVWKGTSEVGCGLKSCGGEWGDYIICSYKAAGNVIGEFADNVMPLA
SIO_010081: YKR013W
subclass of: SO_0000673
so part of: YKR013W
location: 463959..464948
location: region:463959-464948:1
so has part: feature:463959-464948:1:exon

NP_012938.3
type: Protein
SIO_000068: ncbiprotein

S000001721
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:463959-464948:1:exon

YKR014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPT52
locus tag: YKR014C
so part of: sequence
location: complement(<465367..>466071)
location: region:465367-466071:-1
so has part: feature:465367-466071:-1:exon
subclass of: SO_0000010

853884
type: Gene
SIO_000068: ncbigene

position:465367:-1
position: 465367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:466071:-1
position: 466071
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465367-466071:-1:exon

YKR014C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPT52
locus tag: YKR014C
product: Rab family GTPase YPT52
transcript id: NM_001179804.1
SIO_010081: YKR014C
subclass of: SO_0000673
so part of: YKR014C
location: complement(<465367..>466071)
location: region:465367-466071:-1
so has part: feature:465367-466071:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465367-466071:-1:exon

YKR014C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPT52
locus tag: YKR014C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:22748138|PMID:23612966]
experiment: EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22748138]
experiment: EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]
experiment: EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:22748138]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]
experiment: EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:22748138]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]
note: Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress
codon start: 1
product: Rab family GTPase YPT52
translation: MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQSITIHPNDGNETKDVVIKFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSLQKARNWVDELKNKVGDDDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAISTEEAKQYAQEQGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKQNRQIGGGNNGQVDINLQRPSTNDPTSCCS
SIO_010081: YKR014C
subclass of: SO_0000673
so part of: YKR014C
location: complement(465367..466071)
location: region:465367-466071:-1
so has part: feature:465367-466071:-1:exon

NP_012939.1
type: Protein
SIO_000068: ncbiprotein

S000001722
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465367-466071:-1:exon

YKR015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR015C
so part of: sequence
location: complement(<466961..>468667)
location: region:466961-468667:-1
so has part: feature:466961-468667:-1:exon
subclass of: SO_0000010

853885
type: Gene
SIO_000068: ncbigene

position:466961:-1
position: 466961
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:468667:-1
position: 468667
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466961-468667:-1:exon

YKR015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR015C
product: uncharacterized protein
transcript id: NM_001179805.3
SIO_010081: YKR015C
subclass of: SO_0000673
so part of: YKR015C
location: complement(<466961..>468667)
location: region:466961-468667:-1
so has part: feature:466961-468667:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466961-468667:-1:exon

YKR015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR015C
codon start: 1
product: uncharacterized protein
translation: MFLDYSGYEALTEINSSFGKYVLLLQQFEGCRSLKDRLQMLKDLGREFMIFENLNVEDFRESKNMIHRFYTMVISLRQIMEIGPLVRRSPAVLVVEFDCPVEDCLDELDPLHPLNRAFIFIHKQWTYYHQYYIVEKVKKVILDMAPVKEDDWSILHKVVYSEGFVERRYKKKKYLGDIYIPQPLMKSNKITTISNFSQLTKISNVRVYRFNATAACDPQNLNKKNLSIKELKDKDLPNLIWTLEPEKFYVDMRPYKEHEERKKRREEEAKVRMQGEEQENIMIERKKMDSIEVEASSGLKNIIKTPLANRVVNTFNNCAAVVIGYVTEVDKVKDDNEEKNNDRPKIANDGIAQKSRSESEDNAGTPMENAYFQPEPQDNDQNNISWNTTMKDIDPIYMSERCARVWRKEQQMLGLEKAQTFEKKYCKDQMVMDENQVEEPGKHSERHTKNQVVRPRTKIASSASKNDNSNNKNSKSCKNCHKEEAHGLVREYLKIKLNISPHGERNQRTKDKRKCIMKYNASSNNINKMPGESEVLGSTILTDIHFKDVVTVKFRDFKAKFRKVKINA
SIO_010081: YKR015C
subclass of: SO_0000673
so part of: YKR015C
location: complement(466961..468667)
location: region:466961-468667:-1
so has part: feature:466961-468667:-1:exon

NP_012940.3
type: Protein
SIO_000068: ncbiprotein

S000001723
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466961-468667:-1:exon

YKR016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM28
alternative label: FCJ1
alternative label: FMP13
gene: MIC60
locus tag: YKR016W
gene synonym: AIM28; FCJ1; FMP13
so part of: sequence
location: <469717..>471339
location: region:469717-471339:1
so has part: feature:469717-471339:1:exon
subclass of: SO_0000010

853886
type: Gene
SIO_000068: ncbigene

position:469717:1
position: 469717
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:471339:1
position: 471339
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469717-471339:1:exon

YKR016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM28
alternative label: FCJ1
alternative label: FMP13
gene: MIC60
locus tag: YKR016W
gene synonym: AIM28; FCJ1; FMP13
product: Mic60p
transcript id: NM_001179806.1
SIO_010081: YKR016W
subclass of: SO_0000673
so part of: YKR016W
location: <469717..>471339
location: region:469717-471339:1
so has part: feature:469717-471339:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469717-471339:1:exon

YKR016W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM28
alternative label: FCJ1
alternative label: FMP13
gene: MIC60
locus tag: YKR016W
gene synonym: AIM28; FCJ1; FMP13
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:19528297]
experiment: EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:19528297]
experiment: EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]
experiment: EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21944719|PMID:21987634|PMID:22009199]
experiment: EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19528297|PMID:21944719|PMID:21987634|PMID:22009199]
experiment: EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:21944719]
experiment: EXISTENCE:physical interaction:GO:0045041 protein import into mitochondrial intermembrane space [PMID:21944719]
note: Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin
codon start: 1
product: Mic60p
translation: MMLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTLWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL
SIO_010081: YKR016W
subclass of: SO_0000673
so part of: YKR016W
location: 469717..471339
location: region:469717-471339:1
so has part: feature:469717-471339:1:exon

NP_012941.1
type: Protein
SIO_000068: ncbiprotein

S000001724
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469717-471339:1:exon

YKR017C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HEL1
locus tag: YKR017C
so part of: sequence
location: complement(<471694..>473349)
location: region:471694-473349:-1
so has part: feature:471694-473349:-1:exon
subclass of: SO_0000010

853887
type: Gene
SIO_000068: ncbigene

position:471694:-1
position: 471694
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:473349:-1
position: 473349
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:471694-473349:-1:exon

YKR017C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HEL1
locus tag: YKR017C
product: E3 ubiquitin-protein ligase HEL1
transcript id: NM_001179807.3
SIO_010081: YKR017C
subclass of: SO_0000673
so part of: YKR017C
location: complement(<471694..>473349)
location: region:471694-473349:-1
so has part: feature:471694-473349:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:471694-473349:-1:exon

YKR017C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HEL1
locus tag: YKR017C
EC number: 2.3.2.31
experiment: EXISTENCE:direct assay:GO:0016574 histone ubiquitination [PMID:22570702]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22570702]
experiment: EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]
note: RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)
codon start: 1
product: E3 ubiquitin-protein ligase HEL1
translation: MSSGTENDQFYSFDESDSSSIELYESHNTSEFTIHGLVFPKLISVTSQDSEFDINEDEDGVDTIYEGMLDAPLTKNNKRILCEGSVPNLSYECLTTKGIFERMLQRVDHLQPIFAIPSADILILLQHYDWNEERLLEVWTEKMDELLVELGLSTTANIKKDNDYNSHFREVEFKNDFTCIICCDKKDTETFALECGHEYCINCYRHYIKDKLHEGNIITCMDCSLALKNEDIDKVMGHPSSSKLMDSSIKSFVQKHNRNYKWCPFADCKSIVHLRDTSSLPEYTRLHYSPFVKCNSFHRFCFNCGFEVHSPADCKITTAWVKKARKESEILNWVLSHTKECPKCSVNIEKNGGCNHMVCSSCKYEFCWICEGPWAPHGKNFFQCTMYKNNEDNKSKNPQDANKTLKKYTFYYRLFNEHEVSAKLDWNLGQTLGTKVHALQERIGISWIDGQFLSESLKVLNEGRTVLKWSFAVAYYSDASHNLTKIFVDNQMLLANAVESLSELLQIKTPEVIMKRRPEFYNKAGYVENRTTALMECGRELLCKGICKAAE
SIO_010081: YKR017C
subclass of: SO_0000673
so part of: YKR017C
location: complement(471694..473349)
location: region:471694-473349:-1
so has part: feature:471694-473349:-1:exon

NP_012942.3
type: Protein
SIO_000068: ncbiprotein

S000001725
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:471694-473349:-1:exon

YKR018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR018C
so part of: sequence
location: complement(<473723..>475900)
location: region:473723-475900:-1
so has part: feature:473723-475900:-1:exon
subclass of: SO_0000010

853888
type: Gene
SIO_000068: ncbigene

position:473723:-1
position: 473723
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475900:-1
position: 475900
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:473723-475900:-1:exon

YKR018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR018C
product: uncharacterized protein
transcript id: NM_001179808.1
SIO_010081: YKR018C
subclass of: SO_0000673
so part of: YKR018C
location: complement(<473723..>475900)
location: region:473723-475900:-1
so has part: feature:473723-475900:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:473723-475900:-1:exon

YKR018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR018C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MFKVFGFGAKEEIPELSQEEKTKAILKQAHDFEQALRAMDYVLDDNADEGLALLDESDAKEASDQTINALARGVIEFLEATLGFEAEEMKKASATLAKAEALSLKSRERAQKIGLKSSSLYPPGTVYAVTYTESCLLHALLMIFSESMMEAAKAILKLRKSYYMLQEILETIKAANKAKKLKITSGSEDKESTPATFITGGDAFNSVDIPYELTPEEQKDKDLLQFAEQIHSMRTERLSGAHIGNSPAINRLRGELGLQAMEDLPEEEITDHKVLSDDIDLSQATIDEFVHSGVNLCFGILQVVISLLPPAIGAVLSVVGFRGSREEGLRLVWKATKQRNVHGCIGLLALMFYYDGPFQFTDDDFDIPAAVKDSSNSEDSEDEEMDGPTLLHPGKILEDALLQSRALFPNSALWLLNEARMLSGKGRLEEAVALMDSIDVSKIRMRQVKSLMIFDRAITLIHLHQYDRAAEDILSLLDISDWSHAFYTYFAGCCYLENWRMCEMGLMKSDKKDEYQKKAEELIFTSVNLLGKKTFKSKNLPLDRFILRKVEQFKAKKEELGVENPLDGIATSPVHEIAYFYNGYNRMSEEHLELTKKMLTEYRNPAIEALDSDQELIKDLLVSLTLRRLGHIQEGCDILDEKVLPKFFSIQNGKVKYIKKTEDPWAYPTALYERALFTWKLEGMDGLPESKEWLLRAQGYADDYELSTRVGMKIKAAIDRVDHSL
SIO_010081: YKR018C
subclass of: SO_0000673
so part of: YKR018C
location: complement(473723..475900)
location: region:473723-475900:-1
so has part: feature:473723-475900:-1:exon

NP_012943.1
type: Protein
SIO_000068: ncbiprotein

S000001726
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:473723-475900:-1:exon

YKR019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRS4
locus tag: YKR019C
so part of: sequence
location: complement(<476216..>478063)
location: region:476216-478063:-1
so has part: feature:476216-478063:-1:exon
subclass of: SO_0000010

853889
type: Gene
SIO_000068: ncbigene

position:476216:-1
position: 476216
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478063:-1
position: 478063
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476216-478063:-1:exon

YKR019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRS4
locus tag: YKR019C
product: Irs4p
transcript id: NM_001179809.3
SIO_010081: YKR019C
subclass of: SO_0000673
so part of: YKR019C
location: complement(<476216..>478063)
location: region:476216-478063:-1
so has part: feature:476216-478063:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476216-478063:-1:exon

YKR019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRS4
locus tag: YKR019C
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18298591]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:18298591]
experiment: EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:18298591]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15265867]
experiment: EXISTENCE:genetic interaction:GO:0048017 inositol lipid-mediated signaling [PMID:15265867]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10082585]
note: EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
codon start: 1
product: Irs4p
translation: MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTTVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS
SIO_010081: YKR019C
subclass of: SO_0000673
so part of: YKR019C
location: complement(476216..478063)
location: region:476216-478063:-1
so has part: feature:476216-478063:-1:exon

NP_012944.3
type: Protein
SIO_000068: ncbiprotein

S000001727
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476216-478063:-1:exon

YKR020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: API3
alternative label: VPS67
alternative label: WHI6
gene: VPS51
locus tag: YKR020W
gene synonym: API3; VPS67; WHI6
so part of: sequence
location: <478338..>478832
location: region:478338-478832:1
so has part: feature:478338-478832:1:exon
subclass of: SO_0000010

853890
type: Gene
SIO_000068: ncbigene

position:478338:1
position: 478338
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478832:1
position: 478832
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:478338-478832:1:exon

YKR020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: API3
alternative label: VPS67
alternative label: WHI6
gene: VPS51
locus tag: YKR020W
gene synonym: API3; VPS67; WHI6
product: Vps51p
transcript id: NM_001179810.1
SIO_010081: YKR020W
subclass of: SO_0000673
so part of: YKR020W
location: <478338..>478832
location: region:478338-478832:1
so has part: feature:478338-478832:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:478338-478832:1:exon

YKR020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: API3
alternative label: VPS67
alternative label: WHI6
gene: VPS51
locus tag: YKR020W
gene synonym: API3; VPS67; WHI6
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12377769]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0007118 budding cell apical bud growth [PMID:11957109]
experiment: EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:12446664]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:12446664]
experiment: EXISTENCE:mutant phenotype:GO:0090156 cellular sphingolipid homeostasis [PMID:26357016]
experiment: EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:12377769|PMID:12446664]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12377769]
note: Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p
codon start: 1
product: Vps51p
translation: MAEQISHKKSLRVSSLNKDRRLLLREFYNLENEPNKGRQEARIGEKASEAHSGEEQVTDVNIDTEANTEKPVKDDELSATEEDLKEGSEDAEEEIKNLPFKRLVQIHNKLLGKETETNNSIKNTIYENYYDLIKVNDLLKEITNANEDQINKLKQTVESLIKEL
SIO_010081: YKR020W
subclass of: SO_0000673
so part of: YKR020W
location: 478338..478832
location: region:478338-478832:1
so has part: feature:478338-478832:1:exon

NP_012945.1
type: Protein
SIO_000068: ncbiprotein

S000001728
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:478338-478832:1:exon

YKR021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ART6
gene: ALY1
locus tag: YKR021W
gene synonym: ART6
so part of: sequence
location: <479234..>481981
location: region:479234-481981:1
so has part: feature:479234-481981:1:exon
subclass of: SO_0000010

853891
type: Gene
SIO_000068: ncbigene

position:479234:1
position: 479234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:481981:1
position: 481981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:479234-481981:1:exon

YKR021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ART6
gene: ALY1
locus tag: YKR021W
gene synonym: ART6
product: Aly1p
transcript id: NM_001179811.4
SIO_010081: YKR021W
subclass of: SO_0000673
so part of: YKR021W
location: <479234..>481981
location: region:479234-481981:1
so has part: feature:479234-481981:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:479234-481981:1:exon

YKR021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ART6
gene: ALY1
locus tag: YKR021W
gene synonym: ART6
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005769 early endosome [PMID:20739461]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:20739461]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:2000397 positive regulation of ubiquitin-dependent endocytosis [PMID:20956561]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:23824189]
experiment: EXISTENCE:mutant phenotype:GO:0032386 regulation of intracellular transport [PMID:20739461]
experiment: EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]
note: Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication
codon start: 1
product: Aly1p
translation: MLQFNTENDTVAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEIAPSILRGSLIVRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQADDGMNSFTLEHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAEPPKDNSNLSLDAYERNSLSSDNLSNKPVSSDVSHDDSKLLAIQKTPLPSSSRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGATPSPEQEDNYLTPSKDSKEVFIFRPGDYIYTFEQPISQSYPESIKANFGSVEYKLSIDIERFGAFKSTIHTQLPIKVVRLPSDGSVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPIDFHFAPLDKVTLHRIRIYLTESMEYTCNSNGNHEKARRLEPTKKFLLAEHNGPKLPHIPAGSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKICLRLSKKYGDNRKHFEISIDSPIHILNQLCSHANTLLPSYESHFQYCDEDGNFAPAADQQNYASHHDSNIFFPKEVLSSPVLSPNVQKMNIRIPSDLPVVRNRAESVKKSKSDNTSKKNDQSSNVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSPPPDFDFDLAKRGAADSHAIPVDPPSYFDVLKADGIELPYYDTSSSKIPELKLNKSRETLASIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSAPSENVNSHTPILQSLNMSLDGRKKNRASLHATSVLPSTIRQNNQHFNDINQMLGSSDEDAFPKSQSLNFNKKLPILKINDNVIQSNSNSNNRVDNPEDTVDSSVDITAFYDPRMSSDSKFDWEVSKNHVDPAAYSVNVASENRVLDDFKKAFREKRK
SIO_010081: YKR021W
subclass of: SO_0000673
so part of: YKR021W
location: 479234..481981
location: region:479234-481981:1
so has part: feature:479234-481981:1:exon

NP_012946.3
type: Protein
SIO_000068: ncbiprotein

S000001729
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:479234-481981:1:exon

YKR022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NTR2
locus tag: YKR022C
so part of: sequence
location: complement(<482171..>483139)
location: region:482171-483139:-1
so has part: feature:482171-483139:-1:exon
subclass of: SO_0000010

853892
type: Gene
SIO_000068: ncbigene

position:482171:-1
position: 482171
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483139:-1
position: 483139
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482171-483139:-1:exon

YKR022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NTR2
locus tag: YKR022C
product: Ntr2p
transcript id: NM_001179812.1
SIO_010081: YKR022C
subclass of: SO_0000673
so part of: YKR022C
location: complement(<482171..>483139)
location: region:482171-483139:-1
so has part: feature:482171-483139:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482171-483139:-1:exon

YKR022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NTR2
locus tag: YKR022C
experiment: EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16357217|PMID:16880513]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:16880513]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:16357217]
experiment: EXISTENCE:mutant phenotype:GO:0000390 spliceosomal complex disassembly [PMID:16880513]
note: Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
codon start: 1
product: Ntr2p
translation: MAIKKRNKIRLPSGSPEEVGIDGSAHKPMQQIKPLVSNDSEDDDNDICVLQPIKFKKVPKRDITFDGEQAIKEDNSHYEDLYHSKKNTNASTRNKDDLLILNMEDLMEGNHHLLSDSSEAGSSSEGEHISSIPTRGEIAKLKAQKSLSRRKISESDVTTERDYVKLLDSEDKREIMETIRLNGGLKRNNEKEITNFSDDEMQGFQDEMLALTDNQIAIQKDSKRKIIEKAINEVPYRTNEEWETQLLSKGNINKSNEKIITPLPVLFPDDDESGNSIERINEMVSKICLQRKKVEMRLQALEKTKIDLEKSKASLINKLIGN
SIO_010081: YKR022C
subclass of: SO_0000673
so part of: YKR022C
location: complement(482171..483139)
location: region:482171-483139:-1
so has part: feature:482171-483139:-1:exon

NP_012947.1
type: Protein
SIO_000068: ncbiprotein

S000001730
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482171-483139:-1:exon

YKR023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RQT4
locus tag: YKR023W
so part of: sequence
location: <483419..>485011
location: region:483419-485011:1
so has part: feature:483419-485011:1:exon
subclass of: SO_0000010

853893
type: Gene
SIO_000068: ncbigene

position:483419:1
position: 483419
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485011:1
position: 485011
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483419-485011:1:exon

YKR023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RQT4
locus tag: YKR023W
product: Rqt4p
transcript id: NM_001179813.3
SIO_010081: YKR023W
subclass of: SO_0000673
so part of: YKR023W
location: <483419..>485011
location: region:483419-485011:1
so has part: feature:483419-485011:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483419-485011:1:exon

YKR023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RQT4
locus tag: YKR023W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:28757607]
note: Subunit of ribosome-associated quality control trigger complex (RQT); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Rqt4p
translation: MTRKQAIDYAIKQVPQILPLEESDVKALCEQVLSTSSDDPEQIASKFLEFLGHEDLSFEFVMKFNELLNQNDKKEEKKTKNVHLEHTAPTSWKNESKQPTNNYINKKGDEKPKKLKDEKKSSTTRPTVQPSNQSTQSNPIKEKKEHRSKGKLQSLQEIDEAIKMLELRDSGSSKNCNCQGTRHPVFDIAPNCLHCGKVVCVIEGLNKGKCGHCHEQLISDNERTQMVEILNQEKNELNGSSSSLSNASNGANVPKKKTKTYKITSGMGKNLFAEQDKLFDFIERKRERERKRNEVLKLQEEKEESEAKERQASEHDHKAEENPELLAAQERLDRLLYFQDTSAERTKIIDNASDFDMNQEVGLWGSARERALALKKQQRNLRKWEKVEKERNGRREKYVVSMNIGSNGKVTMTEVPKDTENVIAGSDDDISDISDEEDISDLKHIHALKSEINTTKSLENLHLQSKAWDYERDKKQFDRPTYVKKNSDTAQQNRKTEEKAHDMQAYDLKSRVQVDQNADASVEQNILAVL
SIO_010081: YKR023W
subclass of: SO_0000673
so part of: YKR023W
location: 483419..485011
location: region:483419-485011:1
so has part: feature:483419-485011:1:exon

NP_012948.3
type: Protein
SIO_000068: ncbiprotein

S000001731
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483419-485011:1:exon

YKR024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DBP7
locus tag: YKR024C
so part of: sequence
location: complement(<485144..>487372)
location: region:485144-487372:-1
so has part: feature:485144-487372:-1:exon
subclass of: SO_0000010

853894
type: Gene
SIO_000068: ncbigene

position:485144:-1
position: 485144
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:487372:-1
position: 487372
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485144-487372:-1:exon

YKR024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DBP7
locus tag: YKR024C
product: putative ATP-dependent RNA helicase
transcript id: NM_001179814.1
SIO_010081: YKR024C
subclass of: SO_0000673
so part of: YKR024C
location: complement(<485144..>487372)
location: region:485144-487372:-1
so has part: feature:485144-487372:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485144-487372:-1:exon

YKR024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DBP7
locus tag: YKR024C
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9582098]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9582098]
experiment: EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:34686661]
note: Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions
codon start: 1
product: putative ATP-dependent RNA helicase
translation: MSDEDSMLLNFTTNEDTAGSSYKQAAKVTGGRWKDRRRMKMKLEGKTVSRKRKANTTGDEGIIPGRGENSIKKLHKESSYSSEEQEKYKGRNAHNTQGRTLPADSQFVSSLFTSNREITTAVNTNIHDENVAINPSNAPLKGDQFASLGVSSLLVSHLEQKMRIKKPTSIQKQAIPQIIGNAGKNDFFIHAQTGSGKTLSYLLPIISTILNMDTHVDRTSGAFALVIAPTRELASQIYHVCSTLVSCCHYLVPCLLIGGERKKSEKARLRKGCNFIIGTPGRVLDHLQNTKVIKEQLSQSLRYIVLDEGDKLMELGFDETISEIIKIVHDIPINSEKFPKLPHKLVHMLCSATLTDGVNRLRNVALKDYKLISNGTKKDSDIVTVAPDQLLQRITIVPPKLRLVTLAATLNNITKDFIASGQQSKTLRTIVFVSCSDSVEFHYDAFSGSDGHHKNLTGDSVRLLTKGNTMFPCFSDSRDPDVVIYKLHGSLSQQMRTSTLQHFARDNEATKGKHLIMFCTDVASRGLDLPHVGSVIELDPPFAVEDHLHRVGRTARAGEKGESLLFLLPGEEEKYMDYIQPYHPMGWELLKFDKEILMPAFKDVNVNRNDKFIRKDEKSSKNKDVGDKEYEWDTNATTWHLNIERRVVGDSAFKNLAVKGFISHVRAYATHISQEKKFFNVKFLHLGHLAKSFGLRERPKAMGLQSSKDGNSEKKPTKENSKNKMFRMARMAEKQIASEFNY
SIO_010081: YKR024C
subclass of: SO_0000673
so part of: YKR024C
location: complement(485144..487372)
location: region:485144-487372:-1
so has part: feature:485144-487372:-1:exon

NP_012949.1
type: Protein
SIO_000068: ncbiprotein

S000001732
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485144-487372:-1:exon

YKR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPC37
locus tag: YKR025W
so part of: sequence
location: <487770..>488618
location: region:487770-488618:1
so has part: feature:487770-488618:1:exon
subclass of: SO_0000010

853895
type: Gene
SIO_000068: ncbigene

position:487770:1
position: 487770
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:488618:1
position: 488618
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487770-488618:1:exon

YKR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPC37
locus tag: YKR025W
product: DNA-directed RNA polymerase III subunit C37
transcript id: NM_001179815.3
SIO_010081: YKR025W
subclass of: SO_0000673
so part of: YKR025W
location: <487770..>488618
location: region:487770-488618:1
so has part: feature:487770-488618:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:487770-488618:1:exon

YKR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPC37
locus tag: YKR025W
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
note: RNA polymerase III subunit C37
codon start: 1
product: DNA-directed RNA polymerase III subunit C37
translation: MSIDNKLFVTEEDEEDRTQDRADVEDESNDIDMIADENGTNSAIANEQEEKSEEVKAEDDTGEEEEDDPVIEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAARYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKGVGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDANVTRKQEDARRNPNPSSQRAQVVTMSVKSVNDPSQNRLTGSLLAHKVADEEANIELTWAEGTFEQFKDTIVKEAEDKTLVALEKQEDYIDNLV
SIO_010081: YKR025W
subclass of: SO_0000673
so part of: YKR025W
location: 487770..488618
location: region:487770-488618:1
so has part: feature:487770-488618:1:exon

NP_012950.3
type: Protein
SIO_000068: ncbiprotein

S000001733
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:487770-488618:1:exon

YKR026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAS2
gene: GCN3
locus tag: YKR026C
gene synonym: AAS2
so part of: sequence
location: complement(<488738..>489655)
location: region:488738-489655:-1
so has part: feature:488738-489655:-1:exon
subclass of: SO_0000010

853896
type: Gene
SIO_000068: ncbigene

position:488738:-1
position: 488738
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:489655:-1
position: 489655
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488738-489655:-1:exon

YKR026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAS2
gene: GCN3
locus tag: YKR026C
gene synonym: AAS2
product: translation initiation factor eIF2B subunit alpha
transcript id: NM_001179816.1
SIO_010081: YKR026C
subclass of: SO_0000673
so part of: YKR026C
location: complement(<488738..>489655)
location: region:488738-489655:-1
so has part: feature:488738-489655:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488738-489655:-1:exon

YKR026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAS2
gene: GCN3
locus tag: YKR026C
gene synonym: AAS2
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:8336705]
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8506384]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384|PMID:8336705]
experiment: EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]
experiment: EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8506384]
experiment: EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:8887689]
experiment: EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8887689]
experiment: EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:8099443|PMID:34223816]
experiment: EXISTENCE:mutant phenotype:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8099443]
experiment: EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:8099443|PMID:9032257]
experiment: EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:8099443|PMID:8887689|PMID:9032257]
experiment: EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:34223816]
experiment: EXISTENCE:mutant phenotype:GO:1900036 positive regulation of cellular response to heat [PMID:34223816]
experiment: EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]
experiment: EXISTENCE:physical interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384]
experiment: EXISTENCE:physical interaction:GO:0006446 regulation of translational initiation [PMID:8887689]
note: Alpha subunit of translation initiation factor eIF2B (eIF2Balpha); guanine-nucleotide exchange factor for eIF2; mutations in eIF2Balpha alter localization of eIF2B; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant
codon start: 1
product: translation initiation factor eIF2B subunit alpha
translation: MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLDFTRRTDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEELIKMWYD
SIO_010081: YKR026C
subclass of: SO_0000673
so part of: YKR026C
location: complement(488738..489655)
location: region:488738-489655:-1
so has part: feature:488738-489655:-1:exon

NP_012951.1
type: Protein
SIO_000068: ncbiprotein

S000001734
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488738-489655:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(490286..490416)
location: region:490286-490416:-1
so has part: feature:490286-490416:-1:region

S000007059
type: SGD
SIO_000068: sgd

position:490286:-1
position: 490286
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:490416:-1
position: 490416
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490286-490416:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 490464..490787
location: region:490464-490787:1
so has part: feature:490464-490787:1:region

S000007062
type: SGD
SIO_000068: sgd

position:490464:1
position: 490464
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:490787:1
position: 490787
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490464-490787:1:region

YNCK0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0017W
so part of: sequence
location: 490968..491040
location: region:490968-491040:1
so has part: feature:490968-491040:1:exon
subclass of: SO_0000663

853897
type: Gene
SIO_000068: ncbigene

position:490968:1
position: 490968
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:491040:1
position: 491040
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490968-491040:1:exon

YNCK0017W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0017W
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCK0017W
subclass of: SO_0000673
so part of: YNCK0017W
location: 490968..491040
location: region:490968-491040:1
so has part: feature:490968-491040:1:exon

S000006703
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490968-491040:1:exon

YKR027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP50
gene: BCH2
locus tag: YKR027W
gene synonym: FMP50
so part of: sequence
location: <491364..>493661
location: region:491364-493661:1
so has part: feature:491364-493661:1:exon
subclass of: SO_0000010

853898
type: Gene
SIO_000068: ncbigene

position:491364:1
position: 491364
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:493661:1
position: 493661
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491364-493661:1:exon

YKR027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP50
gene: BCH2
locus tag: YKR027W
gene synonym: FMP50
product: Bch2p
transcript id: NM_001179817.3
SIO_010081: YKR027W
subclass of: SO_0000673
so part of: YKR027W
location: <491364..>493661
location: region:491364-493661:1
so has part: feature:491364-493661:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491364-493661:1:exon

YKR027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP50
gene: BCH2
locus tag: YKR027W
gene synonym: FMP50
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:16498409]
experiment: EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:17000877]
experiment: EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]
experiment: EXISTENCE:physical interaction:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:16498409]
note: Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
codon start: 1
product: Bch2p
translation: MSFLWGSTKSKKGKNKKAAGSLPSGVVPQQRVKPTRKNVPIDYPRTLEKVHGESLIFRTSLLSELVSTGKSGIGPPDLIHCTELDKFHDEKIGEFFYITGIDASSVSMPIAFLKLIKWNDGKKLKSASLKNDDITTYCTFNIFQKLDIRLRYESEDVYQVNIVDCLNGNNEIPLSDLIWEETFVSCCIRSVIINSDFERKIPGLVELPFVFENRCASDYKRVIDSLCKFLPRFLECGWDSTKSVYATILNNYLTESLLVFLSITPEFITDYAIQVLDNLMTNDPSNSRYYAIVIISIMERSNDRDVEMIKRIHEILDLLLPVLYGLPSDEPYISDLINCITDVLSIQARFLLNNNDYELSLSISTLATNLSSDNFESWYLLSKGYIFSQQYDKALLSINSMPCLAEYDIVKQAQINAFKFYMNYYKAPLCHSREHCTMTSHELNHLMNIMHYENELELKTIIFGRTVMPNESKYGCIEEIWNKSCLELGPICGPQSDNLINFVSQQEVNTVGDMLLLKRSKETRQESWFIKQVRLLLMELVARIGWNALLQLRSDVFVMESKFKMIESSDKLSTELRQKRLCQRWFDAMFLDVYEDLSISTSSQENKATAKYSGLEWELLGLTLLRVSDLPDAVACLRTSILARFDPISCHHLLNFYLTMDFNDEFMRRFDVDIILDLLVKLISFRIRFYDRFQIFSLQVLRKLEGQLGSEIIKNKIINSPYGQAGITSVIDYMLECLSKNRNEACLAYERPLPDLPSTIKPLAD
SIO_010081: YKR027W
subclass of: SO_0000673
so part of: YKR027W
location: 491364..493661
location: region:491364-493661:1
so has part: feature:491364-493661:1:exon

NP_012952.3
type: Protein
SIO_000068: ncbiprotein

S000001735
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491364-493661:1:exon

YKR028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SAP190
locus tag: YKR028W
so part of: sequence
location: <494257..>497358
location: region:494257-497358:1
so has part: feature:494257-497358:1:exon
subclass of: SO_0000010

853899
type: Gene
SIO_000068: ncbigene

position:494257:1
position: 494257
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:497358:1
position: 497358
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494257-497358:1:exon

YKR028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SAP190
locus tag: YKR028W
product: Sap190p
transcript id: NM_001179818.2
SIO_010081: YKR028W
subclass of: SO_0000673
so part of: YKR028W
location: <494257..>497358
location: region:494257-497358:1
so has part: feature:494257-497358:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494257-497358:1:exon

YKR028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SAP190
locus tag: YKR028W
experiment: EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:18755837]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:15367655]
note: Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
codon start: 1
product: Sap190p
translation: MSGSFWKFGQDYSIESPVSKILNSAFIKINKDQDDDVPTGTCEENIADDEDNSSHDYAASEDNVVNENEEKEEENTLPTTESEYENYRPNLDVLDDLLDDDELYTELMCSNFKLLIFLKYPDVLSKLIEYVTNEKILDEETDSAKKPEIIEGVNDHPILIERDRKDKKEDAEEGGDSEETTNDSDHDSGDERSVDSEETSITLPPESEEQVETRRARIAAEILSADVWPISAAIMQNKDLLGRLWSILDHPAPLPIPASTYFMKINERLLDMDITGMLEFILSRDSLVARFLTHVDNPSLMDFLLKVISTDKPDSPTGVIKILKSQELIPKLLDHLNPEYGISTQSAAGDFIKAFVTLSTNSSNELASGIGPNELTRQLVSEEMIEKLIKIMLKGGTSLSNGVGIIIELIRKNNSDYDFIQLVYTTLESHPPTDRDPIHLIHLVKLFAKHMPDFADMLDKTKLPLMEMPFGNIEPLGFERFKICELIAELLHCSNMTLLNEPNGEMIAQERDIERAKELETSTEKENITAIVDNKSSYYDKDCVEKDITENLGALQINNQGSEEDELNDTGVSSVKLDVKSDAKVVEGLENDASGVELYDETLSDTESVRECLREKPLVGDRLKIALEDTKILISILDMFTEFPWNNFLHNVIFDIAQQIFNGPLKTGYNRFLLKDYLVDAYLTKKIVDADKACQDYEKKTGLRYGYMGHLTLVAEEISKFKEYIDEMKLTFCNTAVSDRLEEPFWKEYSETILADTREKYNTVLGDFGNDQESDDDVIRNSDSEDIIGDTEGNENYGNGENDELLSNGHDSGNMDLYYNFNNNENEENEEDYAEYSDVDNKNYYNNVETNDDDYDSDDGKSKSAESEFTDKISEHRDGNSLYNEDNDENGSDKWTSGTSLFPPDHFPSRSQPSDPKLQDQNIFHHQFDFEGVGDDDDYMDPNDDGQSYARPGNPLYTTPKTPPRPKTILFNSLSALDNNGEDEEVALGTSVDDRMDNEISSDEEDSEDEDEENDMGNEEGYSLYRSRSKEAF
SIO_010081: YKR028W
subclass of: SO_0000673
so part of: YKR028W
location: 494257..497358
location: region:494257-497358:1
so has part: feature:494257-497358:1:exon

NP_012953.2
type: Protein
SIO_000068: ncbiprotein

S000001736
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494257-497358:1:exon

YKR029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SET3
locus tag: YKR029C
so part of: sequence
location: complement(<497578..>499833)
location: region:497578-499833:-1
so has part: feature:497578-499833:-1:exon
subclass of: SO_0000010

853900
type: Gene
SIO_000068: ncbigene

position:497578:-1
position: 497578
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499833:-1
position: 499833
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497578-499833:-1:exon

YKR029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SET3
locus tag: YKR029C
product: histone-binding protein SET3
transcript id: NM_001179819.3
SIO_010081: YKR029C
subclass of: SO_0000673
so part of: YKR029C
location: complement(<497578..>499833)
location: region:497578-499833:-1
so has part: feature:497578-499833:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:497578-499833:-1:exon

YKR029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SET3
locus tag: YKR029C
experiment: EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]
experiment: EXISTENCE:mutant phenotype:GO:0006479 protein methylation [PMID:31960028]
experiment: EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:11711434]
note: Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
codon start: 1
product: histone-binding protein SET3
translation: MSVPNSKEQSLLDDASTLLLFSKGKKRAEEASKIGSKTDTIEHDESHEREKKGAIEMAAAALATASTVSLPLKKATEQSAAEAATSTAAKEETENQPQKQPQWPVPDSYIVDPDAGIITCICDLNDDDGFTIQCDHCNRWQHAICYGIKDIGMAPDDYLCNSCDPREVDINLARKIQQERINVKTVEPSSSNNSASNKNNGRDRASSTTISDVGDSFSTDQDNTNHRDKRRKRNPSNNSIDSKNESASVNSSDGLTSMPKKKEHFLSAKDAYGAIYLPLKDNVFKSDLIEPFLNKHMDDNWVIQYPHKTFKSVSIEVKPYADIAYSRTYPGFTKLGVYLKKDCIKGDFIQEILGELDFYKNYLTDPRNHYRIWGTAKRRVIFHSHWPIYIDARLSGNSTRYLRRSCQPNVELVTIKLQDTDNRNDKSSGRKSSRIKFVLRALRDISEDEELYIKWQWDSKHPILKLIKGMTIDSLDDLERYGLINSVETILSNGECGCGNNSKDCYLLKVKRYAQSLYKSVKSRGKMNNRYKLNEILNQYNCKKRREPPILHRLEEKAQNTIERAPILLNNFYRQKFLNRNNGPKIPQKNTIDSTNNPDDIAKPFKFALFAQHSSNISVPKKNETSEKPLIITKSTDYDESHITNIEELPIPVLLPINKTSRQTANDVEESQSKNEHKLSRTPSLSNFNKELSKEAQHSQAKTKEIMTEASVNSRRESTPESIMHLSDFSSSQLHSKKKLSFADYRKKLLK
SIO_010081: YKR029C
subclass of: SO_0000673
so part of: YKR029C
location: complement(497578..499833)
location: region:497578-499833:-1
so has part: feature:497578-499833:-1:exon

NP_012954.3
type: Protein
SIO_000068: ncbiprotein

S000001737
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:497578-499833:-1:exon

YKR030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MSG1
gene: GMH1
locus tag: YKR030W
gene synonym: MSG1
so part of: sequence
location: <500282..>501103
location: region:500282-501103:1
so has part: feature:500282-501103:1:exon
subclass of: SO_0000010

853901
type: Gene
SIO_000068: ncbigene

position:500282:1
position: 500282
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:501103:1
position: 501103
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:500282-501103:1:exon

YKR030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MSG1
gene: GMH1
locus tag: YKR030W
gene synonym: MSG1
product: Gmh1p
transcript id: NM_001179820.1
SIO_010081: YKR030W
subclass of: SO_0000673
so part of: YKR030W
location: <500282..>501103
location: region:500282-501103:1
so has part: feature:500282-501103:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:500282-501103:1:exon

YKR030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MSG1
gene: GMH1
locus tag: YKR030W
gene synonym: MSG1
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12808035]
experiment: EXISTENCE:physical interaction:GO:0016192 vesicle-mediated transport [PMID:12808035]
note: Golgi membrane hypothetical protein; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; conserved from yeast to human
codon start: 1
product: Gmh1p
translation: MSYLPTYSNDLPAGPQGQRRRNNGNENDARQGYGQQSVPMVIRRLFKTPKNLDLETASWEMFHLIFHPRKAYRSIYYQRQTKNQWARDDPSFFIFQIALISLSSIIWSIYNSGFNNDSDMGALSIIGHFFKSLVMMVILDFFIFGFIMATIFYLLLNRSHFKFKSSQNSVVEWAYCFDVHCNSFLIILLCLYFIQFLLLPIINLQNWISLLIGNSLYCFAIGHYFILTFYGYNQLPFLKNLNFILLPTLGLSIIYLISLFGIDLSKKLSFYNY
SIO_010081: YKR030W
subclass of: SO_0000673
so part of: YKR030W
location: 500282..501103
location: region:500282-501103:1
so has part: feature:500282-501103:1:exon

NP_012955.1
type: Protein
SIO_000068: ncbiprotein

S000001738
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:500282-501103:1:exon

YKR031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PLD1
gene: SPO14
locus tag: YKR031C
gene synonym: PLD1
so part of: sequence
location: complement(<501344..>506395)
location: region:501344-506395:-1
so has part: feature:501344-506395:-1:exon
subclass of: SO_0000010

853902
type: Gene
SIO_000068: ncbigene

position:501344:-1
position: 501344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:506395:-1
position: 506395
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501344-506395:-1:exon

YKR031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PLD1
gene: SPO14
locus tag: YKR031C
gene synonym: PLD1
product: phospholipase D
transcript id: NM_001179821.3
SIO_010081: YKR031C
subclass of: SO_0000673
so part of: YKR031C
location: complement(<501344..>506395)
location: region:501344-506395:-1
so has part: feature:501344-506395:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:501344-506395:-1:exon

YKR031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PLD1
gene: SPO14
locus tag: YKR031C
gene synonym: PLD1
EC number: 3.1.4.4
experiment: EXISTENCE:direct assay:GO:0004630 phospholipase D activity [PMID:11514437]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:9693364]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21954159]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:10848624]
experiment: EXISTENCE:direct assay:GO:0006644 phospholipid metabolic process [PMID:8576189]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:genetic interaction:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:18036176]
experiment: EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:12702348]
experiment: EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:8576189]
experiment: EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:16554438]
note: Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
codon start: 1
product: phospholipase D
translation: MSNVSTASGTHFAPPQADRSVTEEVDRVNSRPDELENQEVLRQLPENGNLTSSLQREKRRTPNGKEAERKHALPKSFVDRNLSDVSPNHSLDHIMHSNEHDPRRGSDEENMHRLYNNLHSSNNNVHSKRNSKREEERAPQRRSSSVAYTQQQFNGWKKEFGHAFKKISAIGRLKSSVNSPTPAGSGHRHNQHQHQQVNEEDLYTQRLASDLLDSLLAGCPASLFASTQFLRDEHGKRRAPLLLAKLDVRVSPLKNDNNILDITNSNHNHRGNNNNNTGENSDRRPSIPRSSSIISISSNVAEFMYSRNENSLFRIHLEYGIDEDRLKWSIIRSYKDIKSLHHKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSENNNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYLRLLNIALCLRPHANRLFEFYELSPLGNLLSRESGFQGKQGYLVIRSTAKAQGWRVSHFGKHAFKDMIDRHTTKWFLVRNSYLTYVSDLSSTTPLDVFLIDWKFKVRFSGNKNNILDNENEINWIIHDPNLEINDELEEFGIENDANNILDKNGKSKTHQKKSNISSKLLLLTLENSERKLKIICKSESSLKQWMSSIIKMSTSTPWSKPNRFGSFAPVRTNSFCKFLVDGRDYFWSLSEALLMAKDVIYIHDWWLSPELYLRRPVKGNQGFRIDRMLKSCAEKGIKIFIVIYRNVGNIVGTDSLWTKHSMLNLHPNIHIIRSPNQWLQNTYFWAHHEKFVVIDETFAFIGGTDLCYGRYDTFEHVLRDDAESLLDQNFPGKDYSNARIADFHDLDKPFESMYDRKVIPRMPWHDVQMMTLGEPARDLARHFVQRWNYLLRAKRPSRLTPLLTPPSDLTAEELKSLPMFEILREKSTCETQILRSAGNWSLGLKETECSIQNAYLKLIEQSEHFIYIENQFFITSTVWNGTCVLNKIGDALVDRIVKANQEKKPWKAFILIPLMPGFDSPVDTAEASSLRLIMQFQYQSISRGEHSTFSKLKKLNIDPAQYIQFFSLRKWSTFAPNERLITEQLYVHAKILIADDRRCIIGSANINERSQLGNRDSEVAILIRDTDLIKTKMNGDDYYAGKFPWELRQRLMREHLGCDVDLVEFVEKKFERFEKFAAKNYEKLHTLSKEGDSGNNWSDREMIDSAMIELGYREIFGCKFSPQWKSGHGNSVDDGSTQCGINEKEVGREDENVYEKFFNSVDYGKSSRKRTPLPKHNFASLGLTFNHRAGIENVGIRDHKVLSTDPRLRKNDEHKKEVDGYGPDCWKKESNKKFKADATEQLKEWALNSLASKVLDDKEMIKSEIPEGFSNYLPNEKDLEMYLTDKTVTNRNKWSMLKRICYLQYLSHKLDERKTQRLKKIKDMRRHLSSSTESTRNGSNSLPLNEKSNEGESTNVDQDIEGDEYHRLHEDILKNQELDDGSLDDLLSQIIPKITNFNSGEIDDAKKEELLKLNFIDPYSFEDPLISSFSEGLWFTIALRNTLLYKLVFHCQPDNAVQNWKEYGEFTELEQEFQINQEKLIDLEAENINSTTTNVVDKDREKEKMRKAAELRMKLSGSLLYGFNQKVFDKHTAQRILERIHGHLVIFPTEWLAKEVESRNWIFNSDRLSPMEIYN
SIO_010081: YKR031C
subclass of: SO_0000673
so part of: YKR031C
location: complement(501344..506395)
location: region:501344-506395:-1
so has part: feature:501344-506395:-1:exon

NP_012956.3
type: Protein
SIO_000068: ncbiprotein

S000001739
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:501344-506395:-1:exon

YKR032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR032W
so part of: sequence
location: <506517..>506831
location: region:506517-506831:1
so has part: feature:506517-506831:1:exon
subclass of: SO_0000010

853903
type: Gene
SIO_000068: ncbigene

position:506517:1
position: 506517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:506831:1
position: 506831
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506517-506831:1:exon

YKR032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR032W
product: uncharacterized protein
transcript id: NM_001348851.1
SIO_010081: YKR032W
subclass of: SO_0000673
so part of: YKR032W
location: <506517..>506831
location: region:506517-506831:1
so has part: feature:506517-506831:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506517-506831:1:exon

YKR032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR032W
note: hypothetical protein; conserved among S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MAYSSLCLCLLFNPKGCSNLHPFVVDNEFPPYHLSLVLIKQQRMLDRNRSWAYLAALWRHPWTVISKCCLVYIYIQRQLEFGYSYCFFDFLLVILSETVVILYY
SIO_010081: YKR032W
subclass of: SO_0000673
so part of: YKR032W
location: 506517..506831
location: region:506517-506831:1
so has part: feature:506517-506831:1:exon

NP_001335791.1
type: Protein
SIO_000068: ncbiprotein

S000001740
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506517-506831:1:exon

YKR034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: UGA43
gene: DAL80
locus tag: YKR034W
gene synonym: UGA43
so part of: sequence
location: <506898..>507707
location: region:506898-507707:1
so has part: feature:506898-507707:1:exon
subclass of: SO_0000010

853904
type: Gene
SIO_000068: ncbigene

position:506898:1
position: 506898
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507707:1
position: 507707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506898-507707:1:exon

YKR034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: UGA43
gene: DAL80
locus tag: YKR034W
gene synonym: UGA43
product: Dal80p
transcript id: NM_001179824.1
SIO_010081: YKR034W
subclass of: SO_0000673
so part of: YKR034W
location: <506898..>507707
location: region:506898-507707:1
so has part: feature:506898-507707:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506898-507707:1:exon

YKR034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: UGA43
gene: DAL80
locus tag: YKR034W
gene synonym: UGA43
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8045902]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11443099]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:8376332]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:7899075|PMID:8045902|PMID:8416910]
experiment: EXISTENCE:mutant phenotype:GO:0090295 nitrogen catabolite repression of transcription [PMID:1944286|PMID:6757722|PMID:7899075]
note: Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
codon start: 1
product: Dal80p
translation: MVLSDSLKLPSPTLSAAAGVDDCDGEDHPTCQNCFTVKTPLWRRDEHGTVLCNACGLFLKLHGEPRPISLKTDTIKSRNRKKLNNNNVNTNANTHSNDPNKIFKRKKRLLTTGGGSLPTNNPKVSILEKFMVSGSIKPLLKPKETVPNTKECSTQRGKFSLDPCEPSGKNYLYQINGSDIYTSNIELTRLPNLSTLLEPSPFSDSAVPEIELTWKLHNEEEVIKLKTKISELELVTDLYKKHIFQLNEKCKQLEVELHSRASVQSHPQH
SIO_010081: YKR034W
subclass of: SO_0000673
so part of: YKR034W
location: 506898..507707
location: region:506898-507707:1
so has part: feature:506898-507707:1:exon

NP_012959.1
type: Protein
SIO_000068: ncbiprotein

S000001742
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506898-507707:1:exon

YKR035W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHM1
alternative label: FTI1
alternative label: VPL30
alternative label: VPS46
gene: DID2
locus tag: YKR035W-A
gene synonym: CHM1; FTI1; VPL30; VPS46
so part of: sequence
location: <507939..>508553
location: region:507939-508553:1
so has part: feature:507939-508553:1:exon
subclass of: SO_0000010

853906
type: Gene
SIO_000068: ncbigene

position:507939:1
position: 507939
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:508553:1
position: 508553
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:507939-508553:1:exon

YKR035W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHM1
alternative label: FTI1
alternative label: VPL30
alternative label: VPS46
gene: DID2
locus tag: YKR035W-A
gene synonym: CHM1; FTI1; VPL30; VPS46
product: Did2p
transcript id: NM_001184309.3
SIO_010081: YKR035W-A
subclass of: SO_0000673
so part of: YKR035W-A
location: <507939..>508553
location: region:507939-508553:1
so has part: feature:507939-508553:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:507939-508553:1:exon

YKR035W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHM1
alternative label: FTI1
alternative label: VPL30
alternative label: VPS46
gene: DID2
locus tag: YKR035W-A
gene synonym: CHM1; FTI1; VPL30; VPS46
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11029042]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11029042]
experiment: EXISTENCE:direct assay:GO:1904902 ESCRT III complex assembly [PMID:31273031]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11029042]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17130288]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12194857]
note: Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
codon start: 1
product: Did2p
translation: MSRNSAAGLENTLFQLKFTSKQLQKQANKASKEEKQETNKLKRALNENEDISRIYASNAIRKKNERLQLLKLASRVDSVASRVQTAVTMRQVSASMGQVCKGMDKALQNMNLQQITMIMDKFEQQFEDLDTSVNVYEDMGVNSDAMLVDNDKVDELMSKVADENGMELKQSAKLDNVPEIKAKEVNVDDEKEDKLAQRLRALRG
SIO_010081: YKR035W-A
subclass of: SO_0000673
so part of: YKR035W-A
location: 507939..508553
location: region:507939-508553:1
so has part: feature:507939-508553:1:exon

NP_012961.3
type: Protein
SIO_000068: ncbiprotein

S000006435
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:507939-508553:1:exon

YKR036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAF4
locus tag: YKR036C
so part of: sequence
location: complement(<508702..>510633)
location: region:508702-510633:-1
so has part: feature:508702-510633:-1:exon
subclass of: SO_0000010

853908
type: Gene
SIO_000068: ncbigene

position:508702:-1
position: 508702
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:510633:-1
position: 510633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:508702-510633:-1:exon

YKR036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAF4
locus tag: YKR036C
product: Caf4p
transcript id: NM_001179826.2
SIO_010081: YKR036C
subclass of: SO_0000673
so part of: YKR036C
location: complement(<508702..>510633)
location: region:508702-510633:-1
so has part: feature:508702-510633:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:508702-510633:-1:exon

YKR036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAF4
locus tag: YKR036C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16009724|PMID:14576278|PMID:16823961|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030014 CCR4-NOT complex [PMID:11113136]
experiment: EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]
experiment: EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:16009724]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11113136]
experiment: EXISTENCE:physical interaction:GO:0000266 mitochondrial fission [PMID:16009724]
experiment: EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11113136]
note: WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication
codon start: 1
product: Caf4p
translation: MGSGDTRGESSLVAKPIEIILNKLPHAILAQQQFQKYITSPIYRYLSKLLLFREVAWPESTKDTQKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQRLLLDNVDGATNSDKEKYVQLPDINTGFVNKTYSRIDLTHLLEDVETNVENLSINKTLEMDELTRLDSMINELESRKLKILERVKHIDSKSTNLENDVTLIKDRINFIEEYNLEADREQSLRKQMEEERSSEASSFTQNEEAISSLCDVESKDTRLKDFYKMPHEKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRIVKVWDLNHGIQVGELPGHLATVNCMQIDKKNYNMLITGSKDATLKLWDLNLSREIYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGKCIQQLDLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDLRVGKPVRLLEGHTDGITSLKFDSEKLVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDGKLITVGANEGGVNVFNMERDEHWMTPEPPHSLDGDELSRRIAIVKYKDGFLINGHNDGDINVWTL
SIO_010081: YKR036C
subclass of: SO_0000673
so part of: YKR036C
location: complement(508702..510633)
location: region:508702-510633:-1
so has part: feature:508702-510633:-1:exon

NP_012962.3
type: Protein
SIO_000068: ncbiprotein

S000001744
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:508702-510633:-1:exon

YKR037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC34
locus tag: YKR037C
so part of: sequence
location: complement(<510910..>511797)
location: region:510910-511797:-1
so has part: feature:510910-511797:-1:exon
subclass of: SO_0000010

853909
type: Gene
SIO_000068: ncbigene

position:510910:-1
position: 510910
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511797:-1
position: 511797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:510910-511797:-1:exon

YKR037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC34
locus tag: YKR037C
product: Spc34p
transcript id: NM_001179827.3
SIO_010081: YKR037C
subclass of: SO_0000673
so part of: YKR037C
location: complement(<510910..>511797)
location: region:510910-511797:-1
so has part: feature:510910-511797:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:510910-511797:-1:exon

YKR037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC34
locus tag: YKR037C
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
codon start: 1
product: Spc34p
translation: MGESLDRCIDDINRAVDSMSTLYFKPPGIFHNAILQGASNKASIRKDITRLIKDCNHDEAYLLFKVNPEKQSVSRRDGKEGVFDYVIKRDTDMKRNRRLGRPGEKPIIHVPKEVYLNKDRLDLNNKRRRTATTSGGGLNGFIFDTDLIGSSVISNSSSGTFKALSAVFKDDPQIQRLLYALENGSVLMEEESNNQRRKTIFVEDFPTDLILKVMAEVTDLWPLTEFKQDYDQLYHNYEQLSSKLRFIKKEVLLQDDRLKTMSQYHPSSSHDVAKIIRKEKDEIRRLEMEIANLQE
SIO_010081: YKR037C
subclass of: SO_0000673
so part of: YKR037C
location: complement(510910..511797)
location: region:510910-511797:-1
so has part: feature:510910-511797:-1:exon

NP_012963.3
type: Protein
SIO_000068: ncbiprotein

S000001745
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:510910-511797:-1:exon

YKR038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KAE1
locus tag: YKR038C
so part of: sequence
location: complement(<511999..>513159)
location: region:511999-513159:-1
so has part: feature:511999-513159:-1:exon
subclass of: SO_0000010

853910
type: Gene
SIO_000068: ncbigene

position:511999:-1
position: 511999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:513159:-1
position: 513159
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:511999-513159:-1:exon

YKR038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KAE1
locus tag: YKR038C
product: tRNA N6-adenosine threonylcarbamoyltransferase
transcript id: NM_001179828.1
SIO_010081: YKR038C
subclass of: SO_0000673
so part of: YKR038C
location: complement(<511999..>513159)
location: region:511999-513159:-1
so has part: feature:511999-513159:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:511999-513159:-1:exon

YKR038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KAE1
locus tag: YKR038C
EC number: 2.3.1.234
experiment: EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16564010|PMID:16874308]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:23620299]
experiment: EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]
experiment: EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21459853|PMID:21183954]
experiment: EXISTENCE:physical interaction:GO:0000723 telomere maintenance [PMID:16564010]
experiment: EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]
note: ADP/GDP nucleotidase, essential functional component of KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; homolog of human OSGEP
codon start: 1
product: tRNA N6-adenosine threonylcarbamoyltransferase
translation: MVNLNTIPPKNGRDYYIALGLEGSANKLGVGIVKHPLLPKHANSDLSYDCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDVICFTKGPGMGAPLHSVVIAARTCSLLWDVPLVGVNHCIGHIEMGREITKAQNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFARTLKIPNEPSPGYNIEQLAKKAPHKENLVELPYTVKGMDLSMSGILASIDLLAKDLFKGNKKNKILFDKTTGEQKVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDNRFCIDNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTDEVYAAWRD
SIO_010081: YKR038C
subclass of: SO_0000673
so part of: YKR038C
location: complement(511999..513159)
location: region:511999-513159:-1
so has part: feature:511999-513159:-1:exon

NP_012964.2
type: Protein
SIO_000068: ncbiprotein

S000001746
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:511999-513159:-1:exon

YNCK0018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0018C
so part of: sequence
location: complement(513332..513403)
location: region:513332-513403:-1
so has part: feature:513332-513403:-1:exon
subclass of: SO_0000663

853911
type: Gene
SIO_000068: ncbigene

position:513332:-1
position: 513332
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:513403:-1
position: 513403
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513332-513403:-1:exon

YNCK0018C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0018C
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCK0018C
subclass of: SO_0000673
so part of: YNCK0018C
location: complement(513332..513403)
location: region:513332-513403:-1
so has part: feature:513332-513403:-1:exon

S000006540
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:513332-513403:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(513532..513846)
location: region:513532-513846:-1
so has part: feature:513532-513846:-1:region

S000007060
type: SGD
SIO_000068: sgd

position:513532:-1
position: 513532
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:513846:-1
position: 513846
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513532-513846:-1:region

YKR039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAP1
locus tag: YKR039W
so part of: sequence
location: <515063..>516871
location: region:515063-516871:1
so has part: feature:515063-516871:1:exon
subclass of: SO_0000010

853912
type: Gene
SIO_000068: ncbigene

position:515063:1
position: 515063
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516871:1
position: 516871
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:515063-516871:1:exon

YKR039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAP1
locus tag: YKR039W
product: amino acid permease GAP1
transcript id: NM_001179829.3
SIO_010081: YKR039W
subclass of: SO_0000673
so part of: YKR039W
location: <515063..>516871
location: region:515063-516871:1
so has part: feature:515063-516871:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:515063-516871:1:exon

YKR039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAP1
locus tag: YKR039W
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:15039776]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:15039776]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9199164|PMID:15623581|PMID:15707981]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:12499351]
experiment: EXISTENCE:genetic interaction:GO:0015193 L-proline transmembrane transporter activity [PMID:14968425]
experiment: EXISTENCE:mutant phenotype:GO:0001761 beta-alanine transmembrane transporter activity [PMID:29570051]
experiment: EXISTENCE:mutant phenotype:GO:0005771 multivesicular body [PMID:14523026]
experiment: EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:6759873]
experiment: EXISTENCE:mutant phenotype:GO:0015171 amino acid transmembrane transporter activity [PMID:6759873]
experiment: EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:15707981]
experiment: EXISTENCE:mutant phenotype:GO:0015846 polyamine transport [PMID:15707981]
note: General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; essential for invasive growth
codon start: 1
product: amino acid permease GAP1
translation: MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC
SIO_010081: YKR039W
subclass of: SO_0000673
so part of: YKR039W
location: 515063..516871
location: region:515063-516871:1
so has part: feature:515063-516871:1:exon

NP_012965.3
type: Protein
SIO_000068: ncbiprotein

S000001747
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:515063-516871:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1116; Autonomously Replicating Sequence
so part of: sequence
location: 517017..517265
location: region:517017-517265:1
so has part: feature:517017-517265:1:region

S000118407
type: SGD
SIO_000068: sgd

position:517017:1
position: 517017
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:517265:1
position: 517265
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517017-517265:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(517453..517784)
location: region:517453-517784:-1
so has part: feature:517453-517784:-1:region

S000007061
type: SGD
SIO_000068: sgd

position:517453:-1
position: 517453
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:517784:-1
position: 517784
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517453-517784:-1:region

YNCK0019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0019W
so part of: sequence
location: 517988..518060
location: region:517988-518060:1
so has part: feature:517988-518060:1:exon
subclass of: SO_0000663

853913
type: Gene
SIO_000068: ncbigene

position:517988:1
position: 517988
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:518060:1
position: 518060
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517988-518060:1:exon

YNCK0019W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0019W
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCK0019W
subclass of: SO_0000673
so part of: YNCK0019W
location: 517988..518060
location: region:517988-518060:1
so has part: feature:517988-518060:1:exon

S000006516
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517988-518060:1:exon

YKR041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR041W
so part of: sequence
location: <518198..>518950
location: region:518198-518950:1
so has part: feature:518198-518950:1:exon
subclass of: SO_0000010

853914
type: Gene
SIO_000068: ncbigene

position:518198:1
position: 518198
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:518950:1
position: 518950
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:518198-518950:1:exon

YKR041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR041W
product: uncharacterized protein
transcript id: NM_001179831.1
SIO_010081: YKR041W
subclass of: SO_0000673
so part of: YKR041W
location: <518198..>518950
location: region:518198-518950:1
so has part: feature:518198-518950:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:518198-518950:1:exon

YKR041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR041W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:21777356]
note: hypothetical protein; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
codon start: 1
product: uncharacterized protein
translation: MSDDDYMNSDDDNDAEKRYVRPIFVRKRRREEDYVATSKDNIHHHPCDWSAKPSQRQNENEQKSTIRLVPVAMNTPKCQEKKKKRKGVGTTSHEATLFEYGESIAGYKCVTTESERDRLKRSHESESSSESEVDVFAFDQAKGISSKVEAEERYARAVRQYWRMTKDEPATLPLPGTPTLAAVSLDMIDDKSVEQFYTMSSALMDANRLDLIRRDRIRWHPDKHRYHKSKVTKLFQAINGLWEQEKTEKR
SIO_010081: YKR041W
subclass of: SO_0000673
so part of: YKR041W
location: 518198..518950
location: region:518198-518950:1
so has part: feature:518198-518950:1:exon

NP_012967.1
type: Protein
SIO_000068: ncbiprotein

S000001749
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:518198-518950:1:exon

YKR042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTH1
locus tag: YKR042W
so part of: sequence
location: <519527..>520624
location: region:519527-520624:1
so has part: feature:519527-520624:1:exon
subclass of: SO_0000010

853916
type: Gene
SIO_000068: ncbigene

position:519527:1
position: 519527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520624:1
position: 520624
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519527-520624:1:exon

YKR042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTH1
locus tag: YKR042W
product: SUN family protein UTH1
transcript id: NM_001179832.3
SIO_010081: YKR042W
subclass of: SO_0000673
so part of: YKR042W
location: <519527..>520624
location: region:519527-520624:1
so has part: feature:519527-520624:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:519527-520624:1:exon

YKR042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTH1
locus tag: YKR042W
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23910823]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:15247238]
experiment: EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:20070376]
note: Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
codon start: 1
product: SUN family protein UTH1
translation: MKLSALLALSASTAVLAAPAVHHSDNHHHNDKRAVVTVTQYVNADGAVVIPAATTATSAAADGKVESVAAATTTLSSTAAAATTSAAASSSSSSSSSSSSSSSVGSGDFEDGTISCSDFPSGQGAVSLDWLGLGGWASIMDMNGNTATSCQDGYYCSYACSPGYAKTQWPSEQPSDGRSVGGLYCKNGKLYRSNTDTNSLCVEGQGSAQAVNKVSGSIAICGTDYPGSENMVVPTVVGAGSSQPINVIKEDSYYQWQGKKTSAQYYVNNAGVSVEDGCIWGTEGSGVGNWAPVVLGAGYTDGITYLSIIPNPNNKEAPNFNIKIVATDGSTVNGACSYENGVYSGSGSDGCTVSVTSGSANFVFY
SIO_010081: YKR042W
subclass of: SO_0000673
so part of: YKR042W
location: 519527..520624
location: region:519527-520624:1
so has part: feature:519527-520624:1:exon

NP_012968.4
type: Protein
SIO_000068: ncbiprotein

S000001750
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519527-520624:1:exon

YKR043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHB17
locus tag: YKR043C
so part of: sequence
location: complement(<520897..>521712)
location: region:520897-521712:-1
so has part: feature:520897-521712:-1:exon
subclass of: SO_0000010

853917
type: Gene
SIO_000068: ncbigene

position:520897:-1
position: 520897
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:521712:-1
position: 521712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520897-521712:-1:exon

YKR043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHB17
locus tag: YKR043C
product: sedoheptulose-bisphosphatase
transcript id: NM_001179833.1
SIO_010081: YKR043C
subclass of: SO_0000673
so part of: YKR043C
location: complement(<520897..>521712)
location: region:520897-521712:-1
so has part: feature:520897-521712:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:520897-521712:-1:exon

YKR043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHB17
locus tag: YKR043C
EC number: 3.1.3.37
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0046390 ribose phosphate biosynthetic process [PMID:21663798]
experiment: EXISTENCE:direct assay:GO:0050278 sedoheptulose-bisphosphatase activity [PMID:21663798]
experiment: EXISTENCE:mutant phenotype:GO:0046390 ribose phosphate biosynthetic process [PMID:21663798]
experiment: EXISTENCE:mutant phenotype:GO:0050278 sedoheptulose-bisphosphatase activity [PMID:21663798]
note: Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
codon start: 1
product: sedoheptulose-bisphosphatase
translation: MPSLTPRCIIVRHGQTEWSKSGQYTGLTDLPLTPYGEGQMLRTGESVFRNNQFLNPDNITYIFTSPRLRARQTVDLVLKPLSDEQRAKIRVVVDDDLREWEYGDYEGMLTREIIELRKSRGLDKERPWNIWRDGCENGETTQQIGLRLSRAIARIQNLHRKHQSEGRASDIMVFAHGHALRYFAAIWFGLGVQKKCETIEEIQNVKSYDDDTVPYVKLESYRHLVDNPCFLLDAGGIGVLSYAHHNIDEPALELAGPFVSPPEEESQHGDV
SIO_010081: YKR043C
subclass of: SO_0000673
so part of: YKR043C
location: complement(520897..521712)
location: region:520897-521712:-1
so has part: feature:520897-521712:-1:exon

NP_012969.1
type: Protein
SIO_000068: ncbiprotein

S000001751
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520897-521712:-1:exon

YKR044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UIP5
locus tag: YKR044W
so part of: sequence
location: <522015..>523346
location: region:522015-523346:1
so has part: feature:522015-523346:1:exon
subclass of: SO_0000010

853918
type: Gene
SIO_000068: ncbigene

position:522015:1
position: 522015
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:523346:1
position: 523346
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:522015-523346:1:exon

YKR044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UIP5
locus tag: YKR044W
product: Uip5p
transcript id: NM_001179834.3
SIO_010081: YKR044W
subclass of: SO_0000673
so part of: YKR044W
location: <522015..>523346
location: region:522015-523346:1
so has part: feature:522015-523346:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:522015-523346:1:exon

YKR044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UIP5
locus tag: YKR044W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11056382]
note: hypothetical protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
codon start: 1
product: Uip5p
translation: MSRDVRAEKLAISLLILSLFLIFQLVAEIYLNNGDQYHTETSPFTRGRSHVTRVPNHDASLSIPFLDKINQFWHVGGATQIRNIQSIKLTQDRDQDKHGLVLSNGIGDNTINDFEIVFTFRISHDPTTQLTGDGMCFAITPENGFLTQNLQSSYAKKQYMMNSQGVIADNTDLMGFPKNLPGLFIVLDTYRNQGHDHKEVPFMDVFINVAPESDWYDINSDGELSTSLRLNSRGHIKLKKNALWNRVTKLRIIYLESISFLKIDVQYAKEGNYWIELFQTTENLYLPKNMHTGQRYIGCSALNGQLTETVELLDVSTSEFHWNDMDASIEDTYDYAKEAELFLEQEFGEVLDREPDEFTKWKMIKAQPNIKTGSQSAEQKTSNNPHSRLFKVVLTIWHYSEILLLIMGIYLFSACIRVFQRRFKKIRSRRKRAGSHSVGLLPM
SIO_010081: YKR044W
subclass of: SO_0000673
so part of: YKR044W
location: 522015..523346
location: region:522015-523346:1
so has part: feature:522015-523346:1:exon

NP_012970.3
type: Protein
SIO_000068: ncbiprotein

S000001752
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:522015-523346:1:exon

YKR045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR045C
so part of: sequence
location: complement(<523418..>523969)
location: region:523418-523969:-1
so has part: feature:523418-523969:-1:exon
subclass of: SO_0000010

853919
type: Gene
SIO_000068: ncbigene

position:523418:-1
position: 523418
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:523969:-1
position: 523969
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523418-523969:-1:exon

YKR045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR045C
product: uncharacterized protein
transcript id: NM_001179835.1
SIO_010081: YKR045C
subclass of: SO_0000673
so part of: YKR045C
location: complement(<523418..>523969)
location: region:523418-523969:-1
so has part: feature:523418-523969:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523418-523969:-1:exon

YKR045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR045C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
note: hypothetical protein; epitope-tagged protein localizes to the cytoplasm
codon start: 1
product: uncharacterized protein
translation: MSNSHHTSQGRRNKLSVWVKKIINTTTTTNASVSSSKPRRGTRAGPTRVKRAELDPDGTTISSSLRPLVDRNSLHSSESDDEGDRRVAWDEPPTGKVRQQQQQQQQQQNDNASVIPLVSFCSSSVKSSTFSDIHSIQSTRPTIFSNRTFETNSSVLAIPPQSILDRSRTLPPSNASNTTTRRP
SIO_010081: YKR045C
subclass of: SO_0000673
so part of: YKR045C
location: complement(523418..523969)
location: region:523418-523969:-1
so has part: feature:523418-523969:-1:exon

NP_012971.2
type: Protein
SIO_000068: ncbiprotein

S000001753
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523418-523969:-1:exon

YKR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PET10
gene: PLN1
locus tag: YKR046C
gene synonym: PET10
so part of: sequence
location: complement(<524223..>525074)
location: region:524223-525074:-1
so has part: feature:524223-525074:-1:exon
subclass of: SO_0000010

853920
type: Gene
SIO_000068: ncbigene

position:524223:-1
position: 524223
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:525074:-1
position: 525074
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:524223-525074:-1:exon

YKR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PET10
gene: PLN1
locus tag: YKR046C
gene synonym: PET10
product: Pln1p
transcript id: NM_001179836.3
SIO_010081: YKR046C
subclass of: SO_0000673
so part of: YKR046C
location: complement(<524223..>525074)
location: region:524223-525074:-1
so has part: feature:524223-525074:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:524223-525074:-1:exon

YKR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PET10
gene: PLN1
locus tag: YKR046C
gene synonym: PET10
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]
experiment: EXISTENCE:expression pattern:GO:0009060 aerobic respiration [PMID:10618406]
note: Perilipin, involved in formation and stability of lipid droplets; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
codon start: 1
product: Pln1p
translation: MSESSISSSKPSVELPQATWSHLQRYPALSKFIKYAESLPPVERLISFNLVVLGSVNQWVSESSSSPRLVKQVVAAGKEGAFKLDELVNLLVFKEGVDGLLYNWKSHSNTPGIWLVWFFVDYVANISNTLLREFLIKPLHLQGSTASKEIGSSGEENKVTDASSLPHVAELSSTTRGMSQEIQSKVKSNYIDPTKDLAKEKYDAIVKPTTDKLQSVYIDPTKTKLNETYQRFTTVYENNLSKSESVPKAIVSTGLDLGNATIEKLKASREDQTNSKPAAVSTN
SIO_010081: YKR046C
subclass of: SO_0000673
so part of: YKR046C
location: complement(524223..525074)
location: region:524223-525074:-1
so has part: feature:524223-525074:-1:exon

NP_012972.3
type: Protein
SIO_000068: ncbiprotein

S000001754
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:524223-525074:-1:exon

YKR048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAP1
locus tag: YKR048C
so part of: sequence
location: complement(<525387..>526640)
location: region:525387-526640:-1
so has part: feature:525387-526640:-1:exon
subclass of: SO_0000010

853922
type: Gene
SIO_000068: ncbigene

position:525387:-1
position: 525387
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:526640:-1
position: 526640
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525387-526640:-1:exon

YKR048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAP1
locus tag: YKR048C
product: histone chaperone NAP1
transcript id: NM_001179838.1
SIO_010081: YKR048C
subclass of: SO_0000673
so part of: YKR048C
location: complement(<525387..>526640)
location: region:525387-526640:-1
so has part: feature:525387-526640:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525387-526640:-1:exon

YKR048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAP1
locus tag: YKR048C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7622566|PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:1400414|PMID:2016313]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:22308335]
experiment: EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]
experiment: EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:22308335]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17289584|PMID:21348863]
experiment: EXISTENCE:direct assay:GO:0043085 positive regulation of catalytic activity [PMID:22308335]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:31062022]
experiment: EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:31062022]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:12456659]
experiment: EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:13680156]
experiment: EXISTENCE:mutant phenotype:GO:0031116 positive regulation of microtubule polymerization [PMID:7622567]
experiment: EXISTENCE:mutant phenotype:GO:0098841 protein localization to cell division site after cytokinesis [PMID:25416945]
experiment: EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:7622566]
note: Histone chaperone and assembly chaperone for Rps6a/b; involved in histone exchange, replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; promotes solubility of Rps6a, and 40S ribosomal subunit biogenesis; role in transport of H2A and H2B histones to the nucleus; regulates microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
codon start: 1
product: histone chaperone NAP1
translation: MSDPIRTKPKSSMQIDNAPTPHNTPASVLNPSYLKNGNPVRAQAQEQDDKIGTINEEDILANQPLLLQSIQDRLGSLVGQDSGYVGGLPKNVKEKLLSLKTLQSELFEVEKEFQVEMFELENKFLQKYKPIWEQRSRIISGQEQPKPEQIAKGQEIVESLNETELLVDEEEKAQNDSEEEQVKGIPSFWLTALENLPIVCDTITDRDAEVLEYLQDIGLEYLTDGRPGFKLLFRFDSSANPFFTNDILCKTYFYQKELGYSGDFIYDHAEGCEISWKDNAHNVTVDLEMRKQRNKTTKQVRTIEKITPIESFFNFFDPPKIQNEDQDEELEEDLEERLALDYSIGEQLKDKLIPRAVDWFTGAALEFEFEEDEEEADEDEDEEEDDDHGLEDDDGESAEEQDDFAGRPEQAPECKQS
SIO_010081: YKR048C
subclass of: SO_0000673
so part of: YKR048C
location: complement(525387..526640)
location: region:525387-526640:-1
so has part: feature:525387-526640:-1:exon

NP_012974.1
type: Protein
SIO_000068: ncbiprotein

S000001756
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525387-526640:-1:exon

YKR049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP46
locus tag: YKR049C
so part of: sequence
location: complement(<526830..>527231)
location: region:526830-527231:-1
so has part: feature:526830-527231:-1:exon
subclass of: SO_0000010

853923
type: Gene
SIO_000068: ncbigene

position:526830:-1
position: 526830
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:527231:-1
position: 527231
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:526830-527231:-1:exon

YKR049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP46
locus tag: YKR049C
product: putative redox protein
transcript id: NM_001179839.3
SIO_010081: YKR049C
subclass of: SO_0000673
so part of: YKR049C
location: complement(<526830..>527231)
location: region:526830-527231:-1
so has part: feature:526830-527231:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:526830-527231:-1:exon

YKR049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP46
locus tag: YKR049C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0051051 negative regulation of transport [PMID:21912684]
note: Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: putative redox protein
translation: MSFWKTLQRQPRTISLFTNDIASNIKSQKCLQLLKGDVSHRFDVEIANRFPTWDQLQYMRTSCPQGPVSLQRQIPKLDSVLKYKHTDPTFGMDLQKCVQRGLWNPKEALWVDWENKLVGNEPADIDKYIIQRK
SIO_010081: YKR049C
subclass of: SO_0000673
so part of: YKR049C
location: complement(526830..527231)
location: region:526830-527231:-1
so has part: feature:526830-527231:-1:exon

NP_012975.3
type: Protein
SIO_000068: ncbiprotein

S000001757
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:526830-527231:-1:exon

YKR050W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPD2
gene: TRK2
locus tag: YKR050W
gene synonym: RPD2
so part of: sequence
location: <527815..>530484
location: region:527815-530484:1
so has part: feature:527815-530484:1:exon
subclass of: SO_0000010

853924
type: Gene
SIO_000068: ncbigene

position:527815:1
position: 527815
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:530484:1
position: 530484
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:527815-530484:1:exon

YKR050W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPD2
gene: TRK2
locus tag: YKR050W
gene synonym: RPD2
product: Trk2p
transcript id: NM_001179840.1
SIO_010081: YKR050W
subclass of: SO_0000673
so part of: YKR050W
location: <527815..>530484
location: region:527815-530484:1
so has part: feature:527815-530484:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:527815-530484:1:exon

YKR050W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPD2
gene: TRK2
locus tag: YKR050W
gene synonym: RPD2
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14570869]
experiment: EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:2072919]
experiment: EXISTENCE:direct assay:GO:0030007 cellular potassium ion homeostasis [PMID:2072919]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:33640956]
experiment: EXISTENCE:mutant phenotype:GO:0042391 regulation of membrane potential [PMID:21424545]
note: Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
codon start: 1
product: Trk2p
translation: MPTAKRTSSRASLALPFQLRLVHKKSWGHRLRDFISGFLKSCRPIAKYVFPNFIVVHYIYLITLSIIGSILLYPCKNTAFIDVLFLAAGASTQGGLATKSTNDFNLYQQIVVYVITLLSTPILIHGFLAFVRLYWFERYFDNIRDISKQNFKLRRTMTLQQRELSGSSGNAARSRSFKDNLFRGKFVSREDPRQSASDVPMDSPDTSALSSISPLNVSSSKEESSDTQSSPPNFSSKRQPSDVDPRDIYKSIMMLQKQQEKSNANSTDSFSSETNGPAFIVQERHERRAPHCSLKRHSVLPSSQELNKLAQTKSFQKLLGLRRDEGDHDYFDGAPHKYMVTKKKKISRTQSCNIPTYTASPSPKTSGQVVENHRNLAKSAPSSFVDEEMSFSPQESLNLQFQAHPPKPKRREGDIGHPFTRTMSTNYLSWQPTFGRNSVFIGLTKQQKEELGGVEYRALRLLCCILMVYYIGFNILAFVTIVPWACTRHHYSEIIRRNGVSPTWWGFFTAMSAFSNLGLSLTADSMVSFDTAPYPLIFMMFFIIIGNTGFPIMLRFIIWIMFKTSRDLSQFKESLGFLLDHPRRCFTLLFPSGPTWWLFTTLVVLNATDWILFIILDFNSAVVRQVAKGYRALMGLFQSVCTRTAGFNVVDLSKLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYDSGQDDENITHEDDIKETDHDGESEERDTVSTKSKPKKQSPKSFVGAHLRRQLSFDLWYLFLGLFIICICEGRKIEDVNKPDFNVFAILFEVVSAYGTVGLSLGYPNTNTSLSAQFTVLSKLVIIAMLIRGRNRGLPYTLDRAIMLPSDKLEQIDRLQDMKAKGKLLAKVGEDPMTTYVKKRSHKLKKIATKFWGKH
SIO_010081: YKR050W
subclass of: SO_0000673
so part of: YKR050W
location: 527815..530484
location: region:527815-530484:1
so has part: feature:527815-530484:1:exon

NP_012976.1
type: Protein
SIO_000068: ncbiprotein

S000001758
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:527815-530484:1:exon

YKR051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HFL1
locus tag: YKR051W
so part of: sequence
location: <530946..>532202
location: region:530946-532202:1
so has part: feature:530946-532202:1:exon
subclass of: SO_0000010

853925
type: Gene
SIO_000068: ncbigene

position:530946:1
position: 530946
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:532202:1
position: 532202
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:530946-532202:1:exon

YKR051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HFL1
locus tag: YKR051W
product: Hfl1p
transcript id: NM_001179841.3
SIO_010081: YKR051W
subclass of: SO_0000673
so part of: YKR051W
location: <530946..>532202
location: region:530946-532202:1
so has part: feature:530946-532202:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:530946-532202:1:exon

YKR051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HFL1
locus tag: YKR051W
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:34088313]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:34088313]
note: Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184
codon start: 1
product: Hfl1p
translation: MENKLLCWWLYWPCVYSSIIATIISFYTITRHLLNYRKPYEQRLSIRILLLVPIFSVSCASGIIKPEAAQFYVDPIREFYEAFVIYTFFTFLTLLLGGERNIITVLSLNHAPTRHPIPLIGKICKPIDLSDPFDFLFVKKGILQYVWFKPFYCFGTLICSAWKLPKFEIFLNVFYNISVTWSLYSLALFWKCLYPELTPYKPWLKFLCVKLIIFASYWQSIIIQGLVVTGKLGTGNQDRTSGYVYKNGLLCIEMVPFAILHAVAFPWNKYTAFSIPYGARMKFIYALKDFLGCGDLIWDFKQTLFAGPLYYNYRNFDPEAMDLLSTRQQSGATMERLKHGLRFTDNGRNSYWVAYGSIDNNLVPESIEESWEDDIAGQRTFPEDPNYPVVHDYTMGHRYSRSMNDLRRDVQSRSSMAC
SIO_010081: YKR051W
subclass of: SO_0000673
so part of: YKR051W
location: 530946..532202
location: region:530946-532202:1
so has part: feature:530946-532202:1:exon

NP_012977.3
type: Protein
SIO_000068: ncbiprotein

S000001759
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:530946-532202:1:exon

YKR052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRS4
locus tag: YKR052C
so part of: sequence
location: complement(<532550..>533464)
location: region:532550-533464:-1
so has part: feature:532550-533464:-1:exon
subclass of: SO_0000010

853926
type: Gene
SIO_000068: ncbigene

position:532550:-1
position: 532550
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:533464:-1
position: 533464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:532550-533464:-1:exon

YKR052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRS4
locus tag: YKR052C
product: Fe(2+) transporter
transcript id: NM_001179842.1
SIO_010081: YKR052C
subclass of: SO_0000673
so part of: YKR052C
location: complement(<532550..>533464)
location: region:532550-533464:-1
so has part: feature:532550-533464:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:532550-533464:-1:exon

YKR052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRS4
locus tag: YKR052C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:1703236]
experiment: EXISTENCE:direct assay:GO:0048250 iron import into the mitochondrion [PMID:12902335]
experiment: EXISTENCE:mutant phenotype:GO:0005381 iron ion transmembrane transporter activity [PMID:12902335]
note: Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication
codon start: 1
product: Fe(2+) transporter
translation: MNTSELSIAEEIDYEALPSHAPLHSQLLAGAFAGIMEHSLMFPIDALKTRVQAAGLNKAASTGMISQISKISTMEGSMALWKGVQSVILGAGPAHAVYFGTYEFCKARLISPEDMQTHQPMKTALSGTIATIAADALMNPFDTVKQRLQLDTNLRVWNVTKQIYQNEGFAAFYYSYPTTLAMNIPFAAFNFMIYESASKFFNPQNSYNPLIHCLCGGISGATCAALTTPLDCIKTVLQVRGSETVSIEIMKDANTFGRASRAILEVHGWKGFWRGLKPRIVANIPATAISWTAYECAKHFLMKN
SIO_010081: YKR052C
subclass of: SO_0000673
so part of: YKR052C
location: complement(532550..533464)
location: region:532550-533464:-1
so has part: feature:532550-533464:-1:exon

NP_012978.1
type: Protein
SIO_000068: ncbiprotein

S000001760
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:532550-533464:-1:exon

YKR053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LBP2
gene: YSR3
locus tag: YKR053C
gene synonym: LBP2
so part of: sequence
location: complement(<534067..>535281)
location: region:534067-535281:-1
so has part: feature:534067-535281:-1:exon
subclass of: SO_0000010

853927
type: Gene
SIO_000068: ncbigene

position:534067:-1
position: 534067
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:535281:-1
position: 535281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:534067-535281:-1:exon

YKR053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LBP2
gene: YSR3
locus tag: YKR053C
gene synonym: LBP2
product: sphinganine kinase YSR3
transcript id: NM_001179843.3
SIO_010081: YKR053C
subclass of: SO_0000673
so part of: YKR053C
location: complement(<534067..>535281)
location: region:534067-535281:-1
so has part: feature:534067-535281:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:534067-535281:-1:exon

YKR053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LBP2
gene: YSR3
locus tag: YKR053C
gene synonym: LBP2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10477278|PMID:10531356]
experiment: EXISTENCE:direct assay:GO:0042392 sphingosine-1-phosphate phosphatase activity [PMID:10856228]
experiment: EXISTENCE:direct assay:GO:0046839 phospholipid dephosphorylation [PMID:10856228]
experiment: EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9353337]
note: Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
codon start: 1
product: sphinganine kinase YSR3
translation: MTIIQTVTELGVTEDTIKVQMAPSGGKHLLADPGNHPAEHFESQMSWLRFQTRQYLTRFTDNQSDFVHSLQKKHRTPFRDVYFKYTSLMGSHMFYVIVLPMPVWLGYRDLTRDMIYVLGYSIYLSGYLKDYWCLPRPKSPPVDRITLSEYTTKEYGAPSSHSANATAVSLLFFWRICLSDTLVWPTKLLLLSLVIFYYLTLVFGRVYCGMHGMLDLFSGAAVGAICFFIRIWVVHALRNFQIGEHLWFPLLSVAWGLFILFNHVRPIDECPCFEDSVAFIGVVSGLDCSDWLTERYGWNLVCSRYASCGSKVFLRPLVGVASVIVWKDVISKTAVYTLLIKLLRFHDDRSEKVHFHNETSEEEECLLYSGVSKVEIVGRFLIYAGIPTTVFLLCPVFFTWTNLR
SIO_010081: YKR053C
subclass of: SO_0000673
so part of: YKR053C
location: complement(534067..535281)
location: region:534067-535281:-1
so has part: feature:534067-535281:-1:exon

NP_012979.3
type: Protein
SIO_000068: ncbiprotein

S000001761
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:534067-535281:-1:exon

YKR054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DHC1
alternative label: PAC6
gene: DYN1
locus tag: YKR054C
gene synonym: DHC1; PAC6
so part of: sequence
location: complement(<535647..>547925)
location: region:535647-547925:-1
so has part: feature:535647-547925:-1:exon
subclass of: SO_0000010

853928
type: Gene
SIO_000068: ncbigene

position:535647:-1
position: 535647
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547925:-1
position: 547925
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535647-547925:-1:exon

YKR054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DHC1
alternative label: PAC6
gene: DYN1
locus tag: YKR054C
gene synonym: DHC1; PAC6
product: dynein heavy chain
transcript id: NM_001179844.1
SIO_010081: YKR054C
subclass of: SO_0000673
so part of: YKR054C
location: complement(<535647..>547925)
location: region:535647-547925:-1
so has part: feature:535647-547925:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:535647-547925:-1:exon

YKR054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DHC1
alternative label: PAC6
gene: DYN1
locus tag: YKR054C
gene synonym: DHC1; PAC6
experiment: EXISTENCE:direct assay:GO:0000235 astral microtubule [PMID:16580990]
experiment: EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:25941405]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16580990]
experiment: EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:12566428|PMID:15965467]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:15642746]
experiment: EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:25941405|PMID:16873064]
experiment: EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:7860634]
experiment: EXISTENCE:genetic interaction:GO:0030473 nuclear migration along microtubule [PMID:9201714]
experiment: EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:9281582]
experiment: EXISTENCE:mutant phenotype:GO:0008569 minus-end-directed microtubule motor activity [PMID:25941405]
experiment: EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9201714]
experiment: EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:21633107]
experiment: EXISTENCE:physical interaction:GO:0005868 cytoplasmic dynein complex [PMID:9658168]
note: Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p
codon start: 1
product: dynein heavy chain
translation: MCKNEARLANELIEFVAATVTGIKNSPKENEQAFIDYLHCQYLERFQFFLGLLDGREFDTLFVFLFEELDRTIVTIDIGEEAIYDANLANKKYSTLLIIKSRSVIVDAEPIATQISAIYLPGPVNAGNLASIITHGVSSVFGQLIKSDTKTYSVETIDKTRRKLDDISKQFQQLHTSIETPDLLAMVPSIIKLAVSKGATSHDYANYLPSNDLESMRFLNILQSIANKWFLVLKQTLAIDRDIKNGSFLDEVEFWSNFYEVLKSLIEQTQSQEFQVCLSVLTNAKRFHNLTNLLNEGSLSDKFKLADKYNQFLSSIPIDEVRQASNLEDLQELFPVLASSLKKFRYSGYPVQRFVVLMDKISQEVMDAILSNLSDLFQLEYGSFLGLYEKSAGMIEEWDDIVQDVNLLIREDLRKRAPQELLIQKLTFTSASVKATLDEILSTRKRFFSLAETIKSISPSTYHEEIQRLYHPFEQIHDISVNFRLKLEQAESEFSKNMLDLEKKLQNTLASFMDSDHCPTEKLSYLVKFKPLMELCPRIKVKVLENQQILLLEIKKDIRQLETGLELLPKILHVEALNNIPPISARISYFLNVQSRIDNIVQYLEALFGSNWNDTLEGRSISTSIVQLRKETNPHDVFLHWLGNFPEKATANLLTTPILKLIRNNEDDYELKVNFDFALAAAYSELRSLTYMAFQVPSHIVRIARTYMYLYPRAINLVELIQTFFSLSKSLSYTFYTNIFLKRNVQTVWLLLQQILITPWESLQEESSEMSCSVHSLARLEKSIDGILSDYQILKNSEPQFAKEFSGLKSFDGTADDLHEVEEIISNIQAIFENLFTKGLTNVSDHISTFNNLIISIILEKVRLNLKKMHFPKHVLKLSFNEGRITSSPSLAAMKRSLLKDIEALLNKVVLINFLHDPDHPLSTTLTFNSLVIKLKDDIQNCIEQVQNLHCKINSYVKEWQKMEFLWQITEEAFLEVVDNSTQRCFGILKGLLDSQSKFDLIISRNNFSKNLVLHTEDAQRHIRSKMDSWILYVSKHLLTIYERDARKLHEDMNRDREAVEDMDINFTSLKNITVIIEAVNVNKRHLTERDIQIKLLGSVMRALTKLKVRFPSHFVYIDQLDNDFSSLRQSLSYVEQELQKHRVVIAKSLEEGVENINNLSQSLNESWSVRKPISPTLTPPEALKILEFFNESITKLKKKMHSVAAAAKMLLIPVVLNDQLTHVVEEVKTYDLVWRSIKNLWEDVQRTFETPWCRVDVLLLQSDLANFLRRADELPRAVKQFEMYKSLFSQVNMLTSVNKILVELKDGALKPRHWNMIFRDIGKRQIQKNLLDKLEFSLKDVMVLNLTLNEILLTKIIERAQKEFVIEKSLNRIKKFWKEAQYEVIEHSSGLKLVREWDVLEQACKEDLEELVSMKASNYYKIFEQDCLDLESKLTKLSEIQVNWVEVQFYWLDLYGILGENLDIQNFLPLETSKFKSLTSEYKMITTRAFQLDTTIEVIHIPNFDTTLKLTIDSLKMIKSSLSTFLERQRRQFPRFYFLGNDDLLKIIGSGKHHDQVSKFMKKMFGSIESIIFLEDFITGVRSVEGEVLNLNEKIELKDSIQAQEWLNILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKYIFQAILLSAQVMWTELVEKCLQTNQFSKYWKEVDMKIKGLLDKLNKSSDNVKKKIEALLVEYLHFNNVIGQLKNCSTKEEARLLWAKVQKFYQKNDTLDDLNSVFISQSGYLLQYKFEYIGIPERLIYTPLLLIGFATLTDSLHQKYGGCFFGPAGTGKTETVKAFGQNLGRVVVVFNCDDSFDYQVLSRLLVGITQIGAWGCFDEFNRLDEKVLSAVSANIQQIQNGLQVGKSHITLLEEETPLSPHTAVFITLNPGYNGRSELPENLKKSFREFSMKSPQSGTIAEMILQIMGFEDSKSLASKIVHFLELLSSKCSSMNHYHFGLRTLKGVLRNCSPLISEFGEGEKTVVESLKR…
SIO_010081: YKR054C
subclass of: SO_0000673
so part of: YKR054C
location: complement(535647..547925)
location: region:535647-547925:-1
so has part: feature:535647-547925:-1:exon

NP_012980.1
type: Protein
SIO_000068: ncbiprotein

S000001762
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:535647-547925:-1:exon

YKR055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RHO4
locus tag: YKR055W
so part of: sequence
location: <548216..>549091
location: region:548216-549091:1
so has part: feature:548216-549091:1:exon
subclass of: SO_0000010

853929
type: Gene
SIO_000068: ncbigene

position:548216:1
position: 548216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549091:1
position: 549091
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548216-549091:1:exon

YKR055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RHO4
locus tag: YKR055W
product: Rho family GTPase RHO4
transcript id: NM_001179845.3
SIO_010081: YKR055W
subclass of: SO_0000673
so part of: YKR055W
location: <548216..>549091
location: region:548216-549091:1
so has part: feature:548216-549091:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548216-549091:1:exon

YKR055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RHO4
locus tag: YKR055W
EC number: 3.6.5.2
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:18417612]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18417612]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:18417612|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:1448099]
experiment: EXISTENCE:genetic interaction:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12810699]
experiment: EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:9184220]
note: Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi
codon start: 1
product: Rho family GTPase RHO4
translation: MNTLLFKRKGGNCGNESNIVSQGSPSSSNLPESPGTLDEKNLPRLPTPFARSLSTIPSYEQMKRTNKLPDYHLKIVVVGDGAVGKTCLLISYVQGTFPTDYIPTIFENYVTNIEGPNGQIIELALWDTAGQEEYSRLRPLSYTNADVLMVCYSVGSKTSLKNVEDLWFPEVKHFCPSTPIMLVGLKSDLYEADNLSDLVEPSSAESLAKRLGAFAHIQCSARLKENIDEVFETAIHTLLSDSLYAPREPTHTIKNPFKRNTTRSDIDSSTGDTSVSISGTKRLRKNKCIIM
SIO_010081: YKR055W
subclass of: SO_0000673
so part of: YKR055W
location: 548216..549091
location: region:548216-549091:1
so has part: feature:548216-549091:1:exon

NP_012981.3
type: Protein
SIO_000068: ncbiprotein

S000001763
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548216-549091:1:exon

YKR056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NUC2
alternative label: NUD1
alternative label: RNC1
gene: TRM2
locus tag: YKR056W
gene synonym: NUC2; NUD1; RNC1
so part of: sequence
location: <549448..>551367
location: region:549448-551367:1
so has part: feature:549448-551367:1:exon
subclass of: SO_0000010

853930
type: Gene
SIO_000068: ncbigene

position:549448:1
position: 549448
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551367:1
position: 551367
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549448-551367:1:exon

YKR056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NUC2
alternative label: NUD1
alternative label: RNC1
gene: TRM2
locus tag: YKR056W
gene synonym: NUC2; NUD1; RNC1
product: tRNA (uracil(54)-C(5))-methyltransferase
transcript id: NM_001179846.1
SIO_010081: YKR056W
subclass of: SO_0000673
so part of: YKR056W
location: <549448..>551367
location: region:549448-551367:1
so has part: feature:549448-551367:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549448-551367:1:exon

YKR056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NUC2
alternative label: NUD1
alternative label: RNC1
gene: TRM2
locus tag: YKR056W
gene synonym: NUC2; NUD1; RNC1
EC number: 2.1.1.35
experiment: EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:17205207]
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:10864043]
experiment: EXISTENCE:direct assay:GO:0030696 tRNA (m5U54) methyltransferase activity [PMID:10864043]
experiment: EXISTENCE:direct assay:GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity [PMID:17205207]
experiment: EXISTENCE:mutant phenotype:GO:0030696 tRNA (m5U54) methyltransferase activity [PMID:10864043]
note: tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
codon start: 1
product: tRNA (uracil(54)-C(5))-methyltransferase
translation: MYEQFEFSFFFFENSDNKVKYKAHLISSIKRWSIITCMRCFWTVQKSIFKARFFACRNFVKKHNYKLISTMTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLNDVTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYYVESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERRKFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI
SIO_010081: YKR056W
subclass of: SO_0000673
so part of: YKR056W
location: 549448..551367
location: region:549448-551367:1
so has part: feature:549448-551367:1:exon

NP_012982.2
type: Protein
SIO_000068: ncbiprotein

S000001764
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549448-551367:1:exon

YKR057W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS25
gene: RPS21A
locus tag: YKR057W
gene synonym: RPS25
so part of: sequence
location: <551657..>552242
location: region:551657-552242:1
so has part: feature:551657-552242:1:exon
subclass of: SO_0000010

853931
type: Gene
SIO_000068: ncbigene

position:551657:1
position: 551657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:552242:1
position: 552242
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551657-552242:1:exon

YKR057W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS25
gene: RPS21A
locus tag: YKR057W
gene synonym: RPS25
product: ribosomal 40S subunit protein S21A
transcript id: NM_001179847.3
SIO_010081: YKR057W
subclass of: SO_0000673
so part of: YKR057W
location: join(<551657..551680,552003..>552242)
location: region:551657-552242:1
so has part: feature:551657-551680:1:exon
so has part: feature:552003-552242:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551657-551680:1:exon

position:551680:1
position: 551680
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:552003-552242:1:exon

position:552003:1
position: 552003
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKR057W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS25
gene: RPS21A
locus tag: YKR057W
gene synonym: RPS25
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]
experiment: EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S21A
translation: MENDKGQLVELYVPRKCSATNRIIKADDHASVQINVAKVDEEGRAIPGEYVTYALSGYVRSRGESDDSLNRLAQNDGLLKNVWSYSR
SIO_010081: YKR057W
subclass of: SO_0000673
so part of: YKR057W
location: join(551657..551680,552003..552242)
location: region:551657-552242:1
so has part: feature:551657-551680:1:exon
so has part: feature:552003-552242:1:exon

NP_012983.3
type: Protein
SIO_000068: ncbiprotein

S000001765
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551657-551680:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:552003-552242:1:exon

YKR058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLG1
locus tag: YKR058W
so part of: sequence
location: <552770..>554620
location: region:552770-554620:1
so has part: feature:552770-554620:1:exon
subclass of: SO_0000010

853932
type: Gene
SIO_000068: ncbigene

position:552770:1
position: 552770
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:554620:1
position: 554620
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552770-554620:1:exon

YKR058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLG1
locus tag: YKR058W
product: glycogenin glucosyltransferase GLG1
transcript id: NM_001179848.1
SIO_010081: YKR058W
subclass of: SO_0000673
so part of: YKR058W
location: <552770..>554620
location: region:552770-554620:1
so has part: feature:552770-554620:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552770-554620:1:exon

YKR058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLG1
locus tag: YKR058W
EC number: 2.4.1.186
experiment: EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:8524228]
experiment: EXISTENCE:genetic interaction:GO:0008466 glycogenin glucosyltransferase activity [PMID:8524228]
note: Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
codon start: 1
product: glycogenin glucosyltransferase GLG1
translation: MYKKLAIATLLYSADYLPGVFALGHQVNKLLEEAGKKGDIETCLIVTTSLFNGTLSELAKNILQSIYTKIVLVEPLNCQEESIQKNSENLALLERPELSFALIKARLWELTQFEQVLYLDSDTLPLNKEFLKLFDIMSKQTTSQVGAIADIGWPDMFNSGVMMLIPDADTASVLQNYIFENTSIDGSDQGILNQFFNQNCCTDELVKDSFSREWVQLSFTYNVTIPNLGYQSSPAMNYFKPSIKLIHFIGKHKPWSLWSQKNFIKNEYHDQWNEVYEEFKEEHQLNNEVSKPKISDSDKTETPETITPVDAPPSNEPTTNQEIDTISTVEENVDNQNAEPVPNSDHSPAPNPVPLDFTKWLTTFINKDHLTNQPVNESREYSKENDNNIINSSSNRDQESPPNSTQELNSSYSVVSTQADSDEHQNAEEEDSTTDNASNSGEESHLDDISTAASSNNNVSNQPDGKNFSNSKENNISVESSPSNPEQKRSTDNIQKPSVSTNDLPDDVEPHTSVDDNIQYLEKDKEGYEEFLPDVYESNAIDNEEEFFDDDARDATEGETKTSAVADKQEDMKLTAEETNQPQQEMPNFKFDWEDSDYLSKVERCFPDDIFEYAVE
SIO_010081: YKR058W
subclass of: SO_0000673
so part of: YKR058W
location: 552770..554620
location: region:552770-554620:1
so has part: feature:552770-554620:1:exon

NP_012984.2
type: Protein
SIO_000068: ncbiprotein

S000001766
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552770-554620:1:exon

YKR059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIF1
locus tag: YKR059W
so part of: sequence
location: <554987..>556174
location: region:554987-556174:1
so has part: feature:554987-556174:1:exon
subclass of: SO_0000010

853933
type: Gene
SIO_000068: ncbigene

position:554987:1
position: 554987
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556174:1
position: 556174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554987-556174:1:exon

YKR059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIF1
locus tag: YKR059W
product: translation initiation factor eIF4A
transcript id: NM_001179849.3
SIO_010081: YKR059W
subclass of: SO_0000673
so part of: YKR059W
location: <554987..>556174
location: region:554987-556174:1
so has part: feature:554987-556174:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554987-556174:1:exon

YKR059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIF1
locus tag: YKR059W
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:1502180]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:1502180]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:1502180]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:24471916]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017|PMID:29192585]
experiment: EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:1502180]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:1502180]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:1502180]
experiment: EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:2648398|PMID:10409745]
note: Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress
codon start: 1
product: translation initiation factor eIF4A
translation: MSEGITDIEESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVMALAFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDEADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVRILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRRKVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEKFYSTQIEELPSDIATLLN
SIO_010081: YKR059W
subclass of: SO_0000673
so part of: YKR059W
location: 554987..556174
location: region:554987-556174:1
so has part: feature:554987-556174:1:exon

NP_012985.3
type: Protein
SIO_000068: ncbiprotein

S000001767
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554987-556174:1:exon

YKR060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP30
locus tag: YKR060W
so part of: sequence
location: <556518..>557342
location: region:556518-557342:1
so has part: feature:556518-557342:1:exon
subclass of: SO_0000010

853934
type: Gene
SIO_000068: ncbigene

position:556518:1
position: 556518
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:557342:1
position: 557342
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:556518-557342:1:exon

YKR060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP30
locus tag: YKR060W
product: Utp30p
transcript id: NM_001179850.1
SIO_010081: YKR060W
subclass of: SO_0000673
so part of: YKR060W
location: <556518..>557342
location: region:556518-557342:1
so has part: feature:556518-557342:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:556518-557342:1:exon

YKR060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP30
locus tag: YKR060W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:22588997]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911|PMID:22588997]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:22588997]
experiment: EXISTENCE:physical interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:21724601]
note: Subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Utp30p is peripherally associated with 90S preribosome and appears partially redundant with its paralog Cic1p
codon start: 1
product: Utp30p
translation: MVESNDIIKSGLAEKALKALILQCEENPSLKNDKDIHIIINTGKKMGINRDNIPRIIPLTKYKLFKPRDLNILLITKDPSALYRETLTKDEHTSELFKEIISVKNLRRRFKGSKLTQLYKDFDLVVADYRVHHLLPEVLGSRFYHGSKKLPYMIRMSKEVKLKRQQMVEKCDPIYVRAQLRSICKNTSYIPNNDNCLSVRVGYIQKHSIPEILQNIQDTINFLTDKSKRPQGGVIKGGIISIFVKTSNSTSLPIYQFSEARENQKNEDLSDIKL
SIO_010081: YKR060W
subclass of: SO_0000673
so part of: YKR060W
location: 556518..557342
location: region:556518-557342:1
so has part: feature:556518-557342:1:exon

NP_012986.1
type: Protein
SIO_000068: ncbiprotein

S000001768
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:556518-557342:1:exon

YKR061W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KTR2
locus tag: YKR061W
so part of: sequence
location: <557677..>558954
location: region:557677-558954:1
so has part: feature:557677-558954:1:exon
subclass of: SO_0000010

853935
type: Gene
SIO_000068: ncbigene

position:557677:1
position: 557677
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558954:1
position: 558954
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557677-558954:1:exon

YKR061W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KTR2
locus tag: YKR061W
product: mannosyltransferase KTR2
transcript id: NM_001179851.3
SIO_010081: YKR061W
subclass of: SO_0000673
so part of: YKR061W
location: <557677..>558954
location: region:557677-558954:1
so has part: feature:557677-558954:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557677-558954:1:exon

YKR061W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KTR2
locus tag: YKR061W
experiment: EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:8631921]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]
experiment: EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:8631921]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:8631921]
note: Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication
codon start: 1
product: mannosyltransferase KTR2
translation: MQICKVFLTQVKKLLFVSLLFCLIAQTCWLALVPYQRQLSLDSYFFRRSREVSSRYDFTRRRHMNQTLKLSSNTYNDEPLNKTKGIKNQRENATLLMLVRNWELSGALRSMRSLEDRFNKNYQYDWTFLNDVPFDQEFIEATTAMASGRTQYALIPAEDWNRPSWINETLFEEALQLMEEKNILYGGSKSYRNMCRFNSGFFFRQKILDPYDFYFRVEPDVEYFCDFPYDPFKVMRQNNKKYGFVITMYEYEDTIPSLWEAVEEYLEETESADIDMESNAFGFVSNFDFIGKSFGVIDSNSGYNLCHFWTNFEIGDLNFFRSEKYIRFFEYLDSKGGFYYERWGDAPVHSIAASLLLKKDEIIHFDELGYKHMPFGTCPSAYYLRLQQRCLCDSNHPDNIDLNVISCLRRWWKDGSGKYFLKHDS
SIO_010081: YKR061W
subclass of: SO_0000673
so part of: YKR061W
location: 557677..558954
location: region:557677-558954:1
so has part: feature:557677-558954:1:exon

NP_012987.3
type: Protein
SIO_000068: ncbiprotein

S000001769
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557677-558954:1:exon

YNCK0020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR42
locus tag: YNCK0020C
so part of: sequence
location: complement(559016..559366)
location: region:559016-559366:-1
so has part: feature:559016-559366:-1:exon
subclass of: SO_0000578

9164915
type: Gene
SIO_000068: ncbigene

position:559016:-1
position: 559016
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:559366:-1
position: 559366
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559016-559366:-1:exon

YNCK0020C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR42
locus tag: YNCK0020C
product: SNR42
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9160748]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376|PMID:9472021]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2975
transcript id: NR_132203.1
SIO_010081: YNCK0020C
subclass of: SO_0000673
so part of: YNCK0020C
location: complement(559016..559366)
location: region:559016-559366:-1
so has part: feature:559016-559366:-1:exon

S000006502
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559016-559366:-1:exon

YKR062W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TFA2
locus tag: YKR062W
so part of: sequence
location: <559666..>560652
location: region:559666-560652:1
so has part: feature:559666-560652:1:exon
subclass of: SO_0000010

853936
type: Gene
SIO_000068: ncbigene

position:559666:1
position: 559666
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560652:1
position: 560652
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559666-560652:1:exon

YKR062W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TFA2
locus tag: YKR062W
product: transcription factor TFIIE subunit TFA2
transcript id: NM_001179852.1
SIO_010081: YKR062W
subclass of: SO_0000673
so part of: YKR062W
location: <559666..>560652
location: region:559666-560652:1
so has part: feature:559666-560652:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559666-560652:1:exon

YKR062W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TFA2
locus tag: YKR062W
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:8702741]
experiment: EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:8702741]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9271406]
experiment: EXISTENCE:direct assay:GO:0005673 transcription factor TFIIE complex [PMID:1429681|PMID:7961670]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:1331084|PMID:1429681|PMID:7961670]
experiment: EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]
experiment: EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:9405484]
experiment: EXISTENCE:physical interaction:GO:0005673 transcription factor TFIIE complex [PMID:9188494]
note: TFIIE small subunit; involved in RNA polymerase II transcription initiation
codon start: 1
product: transcription factor TFIIE subunit TFA2
translation: MSKNRDPLLANLNAFKSKVKSAPVIAPAKVGQKKTNDTVITIDGNTRKRTASERAQENTLNSAKNPVLVDIKKEAGSNSSNAISLDDDDDDEDFGSSPSKKVRPGSIAAAALQANQTDISKSHDSSKLLWATEYIQKKGKPVLVNELLDYLSMKKDDKVIELLKKLDRIEFDPKKGTFKYLSTYDVHSPSELLKLLRSQVTFKGISCKDLKDGWPQCDETINQLEEDSKILVLRTKKDKTPRYVWYNSGGNLKCIDEEFVKMWENVQLPQFAELPRKLQDLGLKPASVDPATIKRQTKRVEVKKKRQRKGKITNTHMTGILKDYSHRV
SIO_010081: YKR062W
subclass of: SO_0000673
so part of: YKR062W
location: 559666..560652
location: region:559666-560652:1
so has part: feature:559666-560652:1:exon

NP_012988.1
type: Protein
SIO_000068: ncbiprotein

S000001770
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559666-560652:1:exon

YKR063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LAS1
locus tag: YKR063C
so part of: sequence
location: complement(<560789..>562297)
location: region:560789-562297:-1
so has part: feature:560789-562297:-1:exon
subclass of: SO_0000010

853937
type: Gene
SIO_000068: ncbigene

position:560789:-1
position: 560789
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:562297:-1
position: 562297
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560789-562297:-1:exon

YKR063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LAS1
locus tag: YKR063C
product: rRNA-processing protein LAS1
transcript id: NM_001179853.3
SIO_010081: YKR063C
subclass of: SO_0000673
so part of: YKR063C
location: complement(<560789..>562297)
location: region:560789-562297:-1
so has part: feature:560789-562297:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560789-562297:-1:exon

YKR063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LAS1
locus tag: YKR063C
experiment: EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]
experiment: EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:26638174]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22083961|PMID:8582632]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23175604]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22083961]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23175604]
experiment: EXISTENCE:mutant phenotype:GO:0000460 maturation of 5.8S rRNA [PMID:22083961]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22083961]
experiment: EXISTENCE:physical interaction:GO:0030687 preribosome, large subunit precursor [PMID:23175604]
note: Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability
codon start: 1
product: rRNA-processing protein LAS1
translation: MIPPRIVPWRDFAELEELKLWFYPKSKGTIEDKRQRAVQRVQSYRLKGSQYLPHVVDSTAQITCAVLLDEKEACLGVHQDSIPIRLSYVMALIRFVNGLLDPTQQSQFAIPLHTLAAKIGLPSWFVDLRHWGTHERDLPGLEMLRWAANEALSWLYDHYWNDEELEDDRDDDDDDDDTGYGYRRNDKLEKYMESLTKTLDKWKRLRNEFLEYKWVWENANDSLITSSNFSGDNLVNYDAEKRKSSHASSSETMIRENLRQWQELWKLSIYHNVVLEKFFNNYDPLLLKVLMLNLNNFDWKVIEWVARNYRTQQDDSNITTILKRKFNAWKELQKRLLDVIINNLNNKNFKNKWQNWEKLIDENASYLILYFCQSMLAKLETEKITGNSWRNKKRRKQIDSTVEIEAKLKENIDNLSLRFNEGEIKLYDFIPAEKDSVPLKKEVSPALKADTNDILGDLASLKQRMSSFGTVGKKNKQEENRATPVKNWSRVQNWKPKPFGVL
SIO_010081: YKR063C
subclass of: SO_0000673
so part of: YKR063C
location: complement(560789..562297)
location: region:560789-562297:-1
so has part: feature:560789-562297:-1:exon

NP_012989.3
type: Protein
SIO_000068: ncbiprotein

S000001771
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560789-562297:-1:exon

YKR064W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OAF3
locus tag: YKR064W
so part of: sequence
location: <562547..>565138
location: region:562547-565138:1
so has part: feature:562547-565138:1:exon
subclass of: SO_0000010

853938
type: Gene
SIO_000068: ncbigene

position:562547:1
position: 562547
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:565138:1
position: 565138
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:562547-565138:1:exon

YKR064W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OAF3
locus tag: YKR064W
product: Oaf3p
transcript id: NM_001179854.1
SIO_010081: YKR064W
subclass of: SO_0000673
so part of: YKR064W
location: <562547..>565138
location: region:562547-565138:1
so has part: feature:562547-565138:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:562547-565138:1:exon

YKR064W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OAF3
locus tag: YKR064W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17551510]
note: Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
codon start: 1
product: Oaf3p
translation: MGYDSQVRTKKRHRITVVCTNCKKRKSKCDRTKPCGTCVRLGDVDSCVYLTDSSGQPESSPSLNDADPLRKQSTPAERISPGFIKKRRSSQTRQDEDHWQRVRELENQSSLYYLPIHEETPFFIDLIPNGFYLETKRSADNLFGLFTDRAIENRDPYLQAMVTFRSIAIKKMMDKLGSNGNNVKNGSLPKSFEALSTFDADDERHISDDVVGKGNNFRMHQTIHKSLFNKFAQYRENNAKKFSSETILAKDYLPPLKILESEVLALFEEKIYNMIPIFDMKVLRHEITIFYQNIVEKGNPISIKHYDHMVFCIILLIIKICRLSVQFSKLTPYIYPVLQEIDTSKFLALVKHYLFETKVLRKCNLLQLQCLILLRFLHWCAPEDGDGPETQYCQILMGTIISSCKEMGINWYCFSHPEKYSFKINRHTRPSYDIMKPSDYISVFRKIWSYVLFWDRKMCFISGEECQIGKTLQCHFKEEADTPTWYIRMLTLDNLMKKINDTLNDDPGKVDLNLLHRLINDLKRNFHILKSLSKNEKETMRHFDFEMEWIIDLFSLSLLHGEMIFYEYDCNITKFYKSFQDLWDMVIHISEKCYNYFFNSDALEVDSLTKFYTNRIVEIVANKVLVIVPAFILRGDRFKTIQYADKKKMIEFLYGVSSVYFNEFGFEYYRCFRKMFTAKIAYKILNRSCEKDAWRIILKFLLNELKLEDNGDSYIDYNDMRLNDICPIILEFQETVQKYDGYRPDILSIWNNEFYPIGKYNDDMTGFKFQMRIKEMQEFLDMEKYSDRFNIFSSFYDHASSQLAKHTEVDTNISITNEQVAEIPQKELLQQPLAPALPVNDLIVSEFDVIEDIFDPVDFVSFF
SIO_010081: YKR064W
subclass of: SO_0000673
so part of: YKR064W
location: 562547..565138
location: region:562547-565138:1
so has part: feature:562547-565138:1:exon

NP_012990.1
type: Protein
SIO_000068: ncbiprotein

S000001772
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:562547-565138:1:exon

YKR065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP18
gene: PAM17
locus tag: YKR065C
gene synonym: FMP18
so part of: sequence
location: complement(<565299..>565892)
location: region:565299-565892:-1
so has part: feature:565299-565892:-1:exon
subclass of: SO_0000010

853939
type: Gene
SIO_000068: ncbigene

position:565299:-1
position: 565299
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:565892:-1
position: 565892
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:565299-565892:-1:exon

YKR065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP18
gene: PAM17
locus tag: YKR065C
gene synonym: FMP18
product: Pam17p
transcript id: NM_001179855.3
SIO_010081: YKR065C
subclass of: SO_0000673
so part of: YKR065C
location: complement(<565299..>565892)
location: region:565299-565892:-1
so has part: feature:565299-565892:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:565299-565892:-1:exon

YKR065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP18
gene: PAM17
locus tag: YKR065C
gene synonym: FMP18
experiment: EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:16107694]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:16107694]
note: Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
codon start: 1
product: Pam17p
translation: MFTSAIRLSSQRLFASQPSVTAAALRSTATTLPLRSYSQPASLQDSSILTWSDFFKLRKQQRRINVGSSLFTALLGCNVSWAYLSTMEIDPTQMLFGFDPLTVISAGIIASGALGYLLGPIVGSQVFKLSHNQQLAQFNNKNKEFLKHIINNRVDASSQSFSNPVPDYYGEKIGSLKEYKQWLRDCHAYAKKAKEFL
SIO_010081: YKR065C
subclass of: SO_0000673
so part of: YKR065C
location: complement(565299..565892)
location: region:565299-565892:-1
so has part: feature:565299-565892:-1:exon

NP_012991.3
type: Protein
SIO_000068: ncbiprotein

S000001773
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:565299-565892:-1:exon

YKR066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CCP1
locus tag: YKR066C
so part of: sequence
location: complement(<566113..>567198)
location: region:566113-567198:-1
so has part: feature:566113-567198:-1:exon
subclass of: SO_0000010

853940
type: Gene
SIO_000068: ncbigene

position:566113:-1
position: 566113
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:567198:-1
position: 567198
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566113-567198:-1:exon

YKR066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CCP1
locus tag: YKR066C
product: cytochrome-c peroxidase
transcript id: NM_001179856.1
SIO_010081: YKR066C
subclass of: SO_0000673
so part of: YKR066C
location: complement(<566113..>567198)
location: region:566113-567198:-1
so has part: feature:566113-567198:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:566113-567198:-1:exon

YKR066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CCP1
locus tag: YKR066C
EC number: 1.11.1.5
experiment: EXISTENCE:direct assay:GO:0004130 cytochrome-c peroxidase activity [PMID:21334283|PMID:17580971]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:11914276|PMID:14576278|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:6290489]
experiment: EXISTENCE:mutant phenotype:GO:0004130 cytochrome-c peroxidase activity [PMID:10589830|PMID:21334283]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10589830]
note: Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress
codon start: 1
product: cytochrome-c peroxidase
translation: MTTAVRLLPSLGRTAHKRSLYLFSAAAAAAAAATFAYSQSQKRSSSSPGGGSNHGWNNWGKAAALASTTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL
SIO_010081: YKR066C
subclass of: SO_0000673
so part of: YKR066C
location: complement(566113..567198)
location: region:566113-567198:-1
so has part: feature:566113-567198:-1:exon

NP_012992.1
type: Protein
SIO_000068: ncbiprotein

S000001774
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566113-567198:-1:exon

YKR067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GAT1
gene: GPT2
locus tag: YKR067W
gene synonym: GAT1
so part of: sequence
location: <567918..>570149
location: region:567918-570149:1
so has part: feature:567918-570149:1:exon
subclass of: SO_0000010

853941
type: Gene
SIO_000068: ncbigene

position:567918:1
position: 567918
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:570149:1
position: 570149
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:567918-570149:1:exon

YKR067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GAT1
gene: GPT2
locus tag: YKR067W
gene synonym: GAT1
product: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2
transcript id: NM_001179857.3
SIO_010081: YKR067W
subclass of: SO_0000673
so part of: YKR067W
location: <567918..>570149
location: region:567918-570149:1
so has part: feature:567918-570149:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:567918-570149:1:exon

YKR067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GAT1
gene: GPT2
locus tag: YKR067W
gene synonym: GAT1
EC number: 2.3.1.15
EC number: 2.3.1.42
experiment: EXISTENCE:direct assay:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19525420|PMID:22267742|PMID:9401016|PMID:14562095|PM ID:11914276|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22267742|PMID:9401016]
experiment: EXISTENCE:direct assay:GO:0008654 phospholipid biosynthetic process [PMID:11544256]
experiment: EXISTENCE:direct assay:GO:0016287 glycerone-phosphate O-acyltransferase activity [PMID:11544256]
experiment: EXISTENCE:mutant phenotype:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:11544256]
experiment: EXISTENCE:mutant phenotype:GO:0090207 regulation of triglyceride metabolic process [PMID:31421179]
note: Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen
codon start: 1
product: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2
translation: MSAPAADHNAAKPIPHVPQASRRYKNSYNGFVYNIHTWLYDVSVFLFNILFTIFFREIKVRGAYNVPEVGVPTILVCAPHANQFIDPALVMSQTRLLKTSAGKSRSRMPCFVTAESSFKKRFISFFGHAMGGIPVPRIQDNLKPVDENLEIYAPDLKNHPEIIKGRSKNPQTTPVNFTKRFSAKSLLGLPDYLSNAQIKEIPDDETIILSSPFRTSKSKVVELLTNGTNFKYAEKIDNTETFQSVFDHLHTKGCVGIFPEGGSHDRPSLLPIKAGVAIMALGAVAADPTMKVAVVPCGLHYFHRNKFRSRAVLEYGEPIVVDGKYGEMYKDSPRETVSKLLKKITNSLFSVTENAPDYDTLMVIQAARRLYQPVKVRLPLPAIVEINRRLLFGYSKFKDDPRIIHLKKLVYDYNRKLDSVGLKDHQVMQLKTTKLEALRCFVTLIVRLIKFSVFAILSLPGSILFTPIFIICRVYSEKKAKEGLKKSLVKIKGTDLLATWKLIVALILAPILYVTYSILLIILARKQHYCRIWVPSNNAFIQFVYFYALLVFTTYSSLKTGEIGVDLFKSLRPLFVSIVYPGKKIEEIQTTRKNLSLELTAVCNDLGPLVFPDYDKLATEIFSKRDGYDVSSDAESSISRMSVQSRSRSSSIHSIGSLASNALSRVNSRGSLTDIPIFSDAKQGQWKSEGETSEDEDEFDEKNPAIVQTARSSDLNKENSRNTNISSKIASLVRQKREHEKKE
SIO_010081: YKR067W
subclass of: SO_0000673
so part of: YKR067W
location: 567918..570149
location: region:567918-570149:1
so has part: feature:567918-570149:1:exon

NP_012993.3
type: Protein
SIO_000068: ncbiprotein

S000001775
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:567918-570149:1:exon

YKR068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BET3
locus tag: YKR068C
so part of: sequence
location: complement(<570328..>570909)
location: region:570328-570909:-1
so has part: feature:570328-570909:-1:exon
subclass of: SO_0000010

853942
type: Gene
SIO_000068: ncbigene

position:570328:-1
position: 570328
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:570909:-1
position: 570909
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:570328-570909:-1:exon

YKR068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BET3
locus tag: YKR068C
product: TRAPP complex core subunit BET3
transcript id: NM_001179858.1
SIO_010081: YKR068C
subclass of: SO_0000673
so part of: YKR068C
location: complement(<570328..>570909)
location: region:570328-570909:-1
so has part: feature:570328-570909:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:570328-570909:-1:exon

YKR068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BET3
locus tag: YKR068C
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0033106 cis-Golgi network membrane [PMID:9564032]
experiment: EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]
experiment: EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:11102533|PMID:17041589|PMID:8590804]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8590804]
experiment: EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:25581738]
experiment: EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17287728]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471|PMID:8590804]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11239471]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:25581738]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:25581738]
note: Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles
codon start: 1
product: TRAPP complex core subunit BET3
translation: MVSTTQSRSLKAMGEEIWKNKTEKINTELFTLTYGSIVAQLCQDYERDFNKVNDHLYSMGYNIGCRLIEDFLARTALPRCENLVKTSEVLSKCAFKIFLNITPNITNWSHNKDTFSLILDENPLADFVELPMDAMKSLWYSNILCGVLKGSLEMVQLDCDVWFVSDILRGDSQTEIKVKLNRILKDEIPIGED
SIO_010081: YKR068C
subclass of: SO_0000673
so part of: YKR068C
location: complement(570328..570909)
location: region:570328-570909:-1
so has part: feature:570328-570909:-1:exon

NP_012994.1
type: Protein
SIO_000068: ncbiprotein

S000001776
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:570328-570909:-1:exon

YKR069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MET20
gene: MET1
locus tag: YKR069W
gene synonym: MET20
so part of: sequence
location: <571612..>573393
location: region:571612-573393:1
so has part: feature:571612-573393:1:exon
subclass of: SO_0000010

853943
type: Gene
SIO_000068: ncbigene

position:571612:1
position: 571612
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:573393:1
position: 573393
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:571612-573393:1:exon

YKR069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MET20
gene: MET1
locus tag: YKR069W
gene synonym: MET20
product: uroporphyrinogen-III C-methyltransferase
transcript id: NM_001179859.3
SIO_010081: YKR069W
subclass of: SO_0000673
so part of: YKR069W
location: <571612..>573393
location: region:571612-573393:1
so has part: feature:571612-573393:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:571612-573393:1:exon

YKR069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MET20
gene: MET1
locus tag: YKR069W
gene synonym: MET20
EC number: 2.1.1.107
experiment: EXISTENCE:direct assay:GO:0004851 uroporphyrin-III C-methyltransferase activity [PMID:10051442]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0019354 siroheme biosynthetic process [PMID:9003798]
note: S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
codon start: 1
product: uroporphyrinogen-III C-methyltransferase
translation: MVRDLVTLPSSLPLITAGFATDQVHLLIGTGSTDSVSVCKNRIHSILNAGGNPIVVNPSSPSHTKQLQLEFGKFAKFEIVEREFRLSDLTTLGRVLVCKVVDRVFVDLPITQSRLCEEIFWQCQKLRIPINTFHKPEFSTFNMIPTWVDPKGSGLQISVTTNGNGYILANRIKRDIISHLPPNISEVVINMGYLKDRIINEDHKALLEEKYYQTDMSLPGFGYGLDEDGWESHKFNKLIREFEMTSREQRLKRTRWLSQIMEYYPMNKLSDIKLEDFETSSSPNKKTKQETVTEGVVPPTDENIENGTKQLQLSEVKKEEGPKKLGKISLVGSGPGSVSMLTIGALQEIKSADIILADKLVPQAILDLIPPKTETFIAKKFPGNAERAQQELLAKGLESLDNGLKVVRLKQGDPYIFGRGGEEFNFFKDHGYIPVVLPGISSSLACTVLAQIPATQRDIADQVLICTGTGRKGALPIIPEFVESRTTVFLMALHRANVLITGLLKHGWDGDVPAAIVERGSCPDQRVTRTLLKWVPEVVEEIGSRPPGVLVVGKAVNALVEKDLINFDESRKFVIDEGFREFEVDVDSLFKLY
SIO_010081: YKR069W
subclass of: SO_0000673
so part of: YKR069W
location: 571612..573393
location: region:571612-573393:1
so has part: feature:571612-573393:1:exon

NP_012995.3
type: Protein
SIO_000068: ncbiprotein

S000001777
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:571612-573393:1:exon

YKR070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR070W
so part of: sequence
location: <573574..>574632
location: region:573574-574632:1
so has part: feature:573574-574632:1:exon
subclass of: SO_0000010

853944
type: Gene
SIO_000068: ncbigene

position:573574:1
position: 573574
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:574632:1
position: 574632
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:573574-574632:1:exon

YKR070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR070W
product: uncharacterized protein
transcript id: NM_001179860.1
SIO_010081: YKR070W
subclass of: SO_0000673
so part of: YKR070W
location: <573574..>574632
location: region:573574-574632:1
so has part: feature:573574-574632:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:573574-574632:1:exon

YKR070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR070W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: uncharacterized protein
translation: MIGKRFFQTTSKKIAFAFDIDGVLFRGKKPIAGASDALKLLNRNKIPYILLTNGGGFSERARTEFISSKLDVDVSPLQIIQSHTPYKSLVNKYSRILAVGTPSVRGVAEGYGFQDVVHQTDIVRYNRDIAPFSGLSDEQVMEYSRDIPDLTTKKFDAVLVFNDPHDWAADIQIISDAINSENGMLNTLRNEKSGKPSIPIYFSNQDLLWANPYKLNRFGQGAFRLLVRRLYLELNGEPLQDYTLGKPTKLTYDFAHHVLIDWEKRLSGKIGQSVKQKLPLLGTKPSTSPFHAVFMVGDNPASDIIGAQNYGWNSCLVKTGVYNEGDDLKECKPTLIVNDVFDAVTKTLEKYA
SIO_010081: YKR070W
subclass of: SO_0000673
so part of: YKR070W
location: 573574..574632
location: region:573574-574632:1
so has part: feature:573574-574632:1:exon

NP_012996.1
type: Protein
SIO_000068: ncbiprotein

S000001778
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:573574-574632:1:exon

YKR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DRE2
locus tag: YKR071C
so part of: sequence
location: complement(<574934..>575980)
location: region:574934-575980:-1
so has part: feature:574934-575980:-1:exon
subclass of: SO_0000010

853945
type: Gene
SIO_000068: ncbigene

position:574934:-1
position: 574934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:575980:-1
position: 575980
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574934-575980:-1:exon

YKR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DRE2
locus tag: YKR071C
product: electron carrier DRE2
transcript id: NM_001179861.3
SIO_010081: YKR071C
subclass of: SO_0000673
so part of: YKR071C
location: complement(<574934..>575980)
location: region:574934-575980:-1
so has part: feature:574934-575980:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574934-575980:-1:exon

YKR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DRE2
locus tag: YKR071C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:18625724]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18625724]
experiment: EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:27166425]
experiment: EXISTENCE:direct assay:GO:0051539 4 iron, 4 sulfur cluster binding [PMID:27166425]
experiment: EXISTENCE:mutant phenotype:GO:0009055 electron transfer activity [PMID:20802492]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20802492|PMID:18625724]
experiment: EXISTENCE:mutant phenotype:GO:0045019 negative regulation of nitric oxide biosynthetic process [PMID:27178802]
experiment: EXISTENCE:mutant phenotype:GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death [PMID:27178802]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27178802]
note: Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1
codon start: 1
product: electron carrier DRE2
translation: MSQYKTGLLLIHPAVTTTPELVENTKAQAASKKVKFVDQFLINKLNDGSITLENAKYETVHYLTPEAQTDIKFPKKLISVLADSLKPNGSLIGLSDIYKVDALINGFEIINEPDYCWIKMDSSKLNQTVSIPLKKKKTNNTKLQSGSKLPTFKKASSSTSNLPSFKKADHSRQPIVKETDSFKPPSFKMTTEPKVYRVVDDLIEDSDDDDFSSDSSKAQYFDQVDTSDDSIEEEELIDEDGSGKSMITMITCGKSKTKKKKACKDCTCGMKEQEENEINDIRSQQDKVVKFTEDELTEIDFTIDGKKVGGCGSCSLGDAFRCSGCPYLGLPAFKPGQPINLDSISDDL
SIO_010081: YKR071C
subclass of: SO_0000673
so part of: YKR071C
location: complement(574934..575980)
location: region:574934-575980:-1
so has part: feature:574934-575980:-1:exon

NP_012997.3
type: Protein
SIO_000068: ncbiprotein

S000001779
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574934-575980:-1:exon

YKR072C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HAL3
gene: SIS2
locus tag: YKR072C
gene synonym: HAL3
so part of: sequence
location: complement(<576435..>578123)
location: region:576435-578123:-1
so has part: feature:576435-578123:-1:exon
subclass of: SO_0000010

853946
type: Gene
SIO_000068: ncbigene

position:576435:-1
position: 576435
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:578123:-1
position: 578123
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:576435-578123:-1:exon

YKR072C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HAL3
gene: SIS2
locus tag: YKR072C
gene synonym: HAL3
product: phosphopantothenoylcysteine decarboxylase complex subunit SIS2
transcript id: NM_001179862.1
SIO_010081: YKR072C
subclass of: SO_0000673
so part of: YKR072C
location: complement(<576435..>578123)
location: region:576435-578123:-1
so has part: feature:576435-578123:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:576435-578123:-1:exon

YKR072C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HAL3
gene: SIS2
locus tag: YKR072C
gene synonym: HAL3
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:7705654]
experiment: EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:9636153]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7705654]
experiment: EXISTENCE:direct assay:GO:0032515 negative regulation of phosphoprotein phosphatase activity [PMID:9636153]
experiment: EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]
experiment: EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]
experiment: EXISTENCE:genetic interaction:GO:0007346 regulation of mitotic cell cycle [PMID:10022927]
experiment: EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19915539]
experiment: EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]
experiment: EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9636153]
note: Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication
codon start: 1
product: phosphopantothenoylcysteine decarboxylase complex subunit SIS2
translation: MTAVASTSGKQDADHNQSIECPRFSRGQKEILLDHEDAKGKDSIINSPVSGRQSISPTLSNATTTTTKSIMNATGTSGAVVSNTPEPGLKRVPAVTFSDLKQQQKQDSLTQLKNDSERTKSPNSNPAPVSNSIPGNHAVIPNHTNTSRTTQLSGSPLVNEMKDYDPKKKDSALKIVDTMKPDKIMATSTPISRENNKVTAKAPTSITLRKEDAQDQANNVSGQINVRSTPEETPVKQSVIPSIIPKRENSKNLDPRLPQDDGKLHVLFGATGSLSVFKIKPMIKKLEEIYGRDRISIQVILTQSATQFFEQRYTKKIIKSSEKLNKMSQYESTPATPVTPTPGQCNMAQVVELPPHIQLWTDQDEWDAWKQRTDPVLHIELRRWADILVVAPLTANTLSKIALGLCDNLLTSVIRAWNPSYPILLAPSMVSSTFNSMMTKKQLQTIKEEMSWVTVFKPSEKVMDINGDIGLGGMMDWNEIVNKIVMKLGGYPKNNEEEDDDEDEEEDDDEEEDTEDKNENNNDDDDDDDDDDDDDDDDDDDDDDDDEDEDEAETPGIIDKHQ
SIO_010081: YKR072C
subclass of: SO_0000673
so part of: YKR072C
location: complement(576435..578123)
location: region:576435-578123:-1
so has part: feature:576435-578123:-1:exon

NP_012998.1
type: Protein
SIO_000068: ncbiprotein

S000001780
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:576435-578123:-1:exon

YKR073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR073C
so part of: sequence
location: complement(<578187..>578507)
location: region:578187-578507:-1
so has part: feature:578187-578507:-1:exon
subclass of: SO_0000010

853947
type: Gene
SIO_000068: ncbigene

position:578187:-1
position: 578187
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:578507:-1
position: 578507
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578187-578507:-1:exon

YKR073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR073C
product: uncharacterized protein
transcript id: NM_001348852.1
SIO_010081: YKR073C
subclass of: SO_0000673
so part of: YKR073C
location: complement(<578187..>578507)
location: region:578187-578507:-1
so has part: feature:578187-578507:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:578187-578507:-1:exon

YKR073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR073C
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MIVFDVSLMIIIIFSFAFNMSQSNILMLYNSPHVLVGSDARNFFSCKKWHRCFSGEVILEEKKSQSALGSRSLTCTCPLISAVQLHLERSFFSLAFFAVILLYIPG
SIO_010081: YKR073C
subclass of: SO_0000673
so part of: YKR073C
location: complement(578187..578507)
location: region:578187-578507:-1
so has part: feature:578187-578507:-1:exon

NP_001335792.1
type: Protein
SIO_000068: ncbiprotein

S000001781
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578187-578507:-1:exon

YNCK0021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCK0021W
so part of: sequence
location: 578965..579060
location: region:578965-579060:1
so has part: feature:578965-579060:1:exon
subclass of: SO_0000663

853948
type: Gene
SIO_000068: ncbigene

position:578965:1
position: 578965
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:579060:1
position: 579060
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:578965-579060:1:exon

YNCK0021W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCK0021W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCK0021W
subclass of: SO_0000673
so part of: YNCK0021W
location: join(578965..579001,579025..579060)
location: region:578965-579060:1
so has part: feature:578965-579001:1:exon
so has part: feature:579025-579060:1:exon

S000006632
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:578965-579001:1:exon

position:579001:1
position: 579001
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:579025-579060:1:exon

position:579025:1
position: 579025
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKR074W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM29
locus tag: YKR074W
so part of: sequence
location: <579209..>579676
location: region:579209-579676:1
so has part: feature:579209-579676:1:exon
subclass of: SO_0000010

853949
type: Gene
SIO_000068: ncbigene

position:579209:1
position: 579209
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:579676:1
position: 579676
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579209-579676:1:exon

YKR074W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM29
locus tag: YKR074W
product: Aim29p
transcript id: NM_001179864.3
SIO_010081: YKR074W
subclass of: SO_0000673
so part of: YKR074W
location: <579209..>579676
location: region:579209-579676:1
so has part: feature:579209-579676:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579209-579676:1:exon

YKR074W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM29
locus tag: YKR074W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
note: hypothetical protein; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
codon start: 1
product: Aim29p
translation: MNSTKRLKMSTTFHDYDLEEPLTSNARPLKNSVITIRVIKSFPYRNVKNIVLHDYDLADKTAKDLFNDVLNKIQNEGSFRPFRNVKFDTLKIYTHAHGSKTVNLVINFDHDDDWTLDIENDKKKLFEYGIENETEISLFNKEDYLRFKENPEEKW
SIO_010081: YKR074W
subclass of: SO_0000673
so part of: YKR074W
location: 579209..579676
location: region:579209-579676:1
so has part: feature:579209-579676:1:exon

NP_013000.3
type: Protein
SIO_000068: ncbiprotein

S000001782
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579209-579676:1:exon

YKR075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YKR075C
so part of: sequence
location: complement(<579827..>580750)
location: region:579827-580750:-1
so has part: feature:579827-580750:-1:exon
subclass of: SO_0000010

853950
type: Gene
SIO_000068: ncbigene

position:579827:-1
position: 579827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:580750:-1
position: 580750
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579827-580750:-1:exon

YKR075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YKR075C
product: uncharacterized protein
transcript id: NM_001179865.1
SIO_010081: YKR075C
subclass of: SO_0000673
so part of: YKR075C
location: complement(<579827..>580750)
location: region:579827-580750:-1
so has part: feature:579827-580750:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579827-580750:-1:exon

YKR075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YKR075C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
note: hypothetical protein; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MTSLDDTIISYQNIMLLDNMTNYNKPAIDYFHHEFNDASLEISASWTLLLKMRKHKLLRLPSCSSEDVLDYNMYLVRLHHCLWRRWSINHYGLQNSKSNPLSINWNKETDVTVLYGPDLTNIDSNENEISPVQNQIDQKQTKNLKSALKKNTECWVTEEVDEINASIESNDNALVKLEDISCPSSVDSHTSSIFDQHSTCTKISSIDEDSEDLMNEKKEQFPRKLKFNQAVMKREIDSKGTIRESLININDIQHSRHHRRHHRRHHHHHHQNSSHSDETIKEAHYEFSNYTFGTMEEDIFYRNQVVF
SIO_010081: YKR075C
subclass of: SO_0000673
so part of: YKR075C
location: complement(579827..580750)
location: region:579827-580750:-1
so has part: feature:579827-580750:-1:exon

NP_013001.1
type: Protein
SIO_000068: ncbiprotein

S000001783
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579827-580750:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1118; Autonomously Replicating Sequence
so part of: sequence
location: 581833..582070
location: region:581833-582070:1
so has part: feature:581833-582070:1:region

S000118408
type: SGD
SIO_000068: sgd

position:581833:1
position: 581833
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:582070:1
position: 582070
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581833-582070:1:region

YKR076W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GTO2
gene: ECM4
locus tag: YKR076W
gene synonym: GTO2
so part of: sequence
location: <582283..>583395
location: region:582283-583395:1
so has part: feature:582283-583395:1:exon
subclass of: SO_0000010

853951
type: Gene
SIO_000068: ncbigene

position:582283:1
position: 582283
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583395:1
position: 583395
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:582283-583395:1:exon

YKR076W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GTO2
gene: ECM4
locus tag: YKR076W
gene synonym: GTO2
product: S-glutathionyl-(chloro)hydroquinone reductase
transcript id: NM_001179866.3
SIO_010081: YKR076W
subclass of: SO_0000673
so part of: YKR076W
location: <582283..>583395
location: region:582283-583395:1
so has part: feature:582283-583395:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:582283-583395:1:exon

YKR076W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GTO2
gene: ECM4
locus tag: YKR076W
gene synonym: GTO2
EC number: 1.8.5.1
EC number: 2.5.1.18
experiment: EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:16709151|PMID:20388120|PMID:22686328]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16936141|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006749 glutathione metabolic process [PMID:20388120|PMID:22686328]
note: S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm
codon start: 1
product: S-glutathionyl-(chloro)hydroquinone reductase
translation: MSKQWASGTNGAFKRQVSSFRETISKQHPIYKPAKGRYWLYVSLACPWAHRTLITRALKGLTSVIGCSVVHWHLDEKGWRFLDMEKQLEDSEDFLEHWHDVAGGIRTAKEDSSKSFAEIKNDSQRFMVDATNEPHYGYKRISDLYYKSDPQYSARFTVPVLWDLETQTIVNNESSEIIRILNSSAFDEFVDDDHKKTDLVPAQLKTQIDDFNSWVYDSINNGVYKTGFAEKAEVYESEVNNVFEHLDKVEKILSDKYSKLKAKYGEEDRQKILGEFFTVGDQLTEADIRLYTTVIRFDPVYVQHFKCNFTSIRAGYPFIHLWVRNLYWNYDAFRYTTDFDHIKLHYTRSHTRINPLGITPLGPKPDIRPL
SIO_010081: YKR076W
subclass of: SO_0000673
so part of: YKR076W
location: 582283..583395
location: region:582283-583395:1
so has part: feature:582283-583395:1:exon

NP_013002.3
type: Protein
SIO_000068: ncbiprotein

S000001784
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:582283-583395:1:exon

YKR077W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSA2
locus tag: YKR077W
so part of: sequence
location: <583653..>584744
location: region:583653-584744:1
so has part: feature:583653-584744:1:exon
subclass of: SO_0000010

853952
type: Gene
SIO_000068: ncbigene

position:583653:1
position: 583653
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:584744:1
position: 584744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:583653-584744:1:exon

YKR077W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSA2
locus tag: YKR077W
product: Msa2p
transcript id: NM_001179867.1
SIO_010081: YKR077W
subclass of: SO_0000673
so part of: YKR077W
location: <583653..>584744
location: region:583653-584744:1
so has part: feature:583653-584744:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:583653-584744:1:exon

YKR077W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSA2
locus tag: YKR077W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:physical interaction:GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:18160399]
note: Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication
codon start: 1
product: Msa2p
translation: MVYTTPQQQQRFSSTPQSSHTLIFSPIRAPSMQTPSSLDYQSPSIVVSSSSMKVHGRSSSFGKFSLSIGQNGKATILGPINVLPTDTSKMEKPVPKKKPVTSDRVEKTRILSLLKKMRNKSSTVNKKYSKVPLKSTTSLQPAATAPSPLVSNIIKPSPKKLASPRTPNANSNLNLNFTSFQIKTGFTPNLDGILLENFTSPNTTADSQGNSASNIINNNHGSANNTNQFLFNLPLQSSPRQFRSPARLIDPLPISDWNTSLLMSPPRTTNFESANNHFNSNFAQASMLRRPSLPHIDEVIPQDSNPANYSDRSDYLSVDQNANNHNGALSEQTYNNIMKSSMISLPIEKDDATMALRKLVSRE
SIO_010081: YKR077W
subclass of: SO_0000673
so part of: YKR077W
location: 583653..584744
location: region:583653-584744:1
so has part: feature:583653-584744:1:exon

NP_013003.1
type: Protein
SIO_000068: ncbiprotein

S000001785
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:583653-584744:1:exon

YKR078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VIN1
gene: VPS501
locus tag: YKR078W
gene synonym: VIN1
so part of: sequence
location: <584952..>586709
location: region:584952-586709:1
so has part: feature:584952-586709:1:exon
subclass of: SO_0000010

853953
type: Gene
SIO_000068: ncbigene

position:584952:1
position: 584952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:586709:1
position: 586709
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584952-586709:1:exon

YKR078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VIN1
gene: VPS501
locus tag: YKR078W
gene synonym: VIN1
product: sorting nexin family protein
transcript id: NM_001179868.3
SIO_010081: YKR078W
subclass of: SO_0000673
so part of: YKR078W
location: <584952..>586709
location: region:584952-586709:1
so has part: feature:584952-586709:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584952-586709:1:exon

YKR078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VIN1
gene: VPS501
locus tag: YKR078W
gene synonym: VIN1
experiment: EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:35098628]
experiment: EXISTENCE:direct assay:GO:0005515 protein binding [PMID:35098628]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:35098628]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:35098628|PMID:11557775]
experiment: EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:35098628]
note: Vacuolar SNX-BAR protein, regulates TORC1 signaling during autophagy induction; binds phosphatidylinositol-3-phosphate; vacuolar localization of Vps501p is dependent upon direct interaction with Iml1p and a unique lipid binding specificity that is also required for its function; VPS501 has paralog VPS5 that arose from the whole genome duplication
codon start: 1
product: sorting nexin family protein
translation: MENDKASHASPSIGVNEFVVQGEISIDDSERSVKSVSVSISDDEDSKTDVQDNMATPSTRSKFQTDLAIDNRLLEKDPKYKKLFTEKRRRRRPESCINLMTKGKGTGQKDNINDQIFSLRILPGSDLNSLKDSLWIIKISTQPDVEKTIARAFSDFYWLYHQLQNNHWGKTIPPPTRSNILVEKDEFAINHLFMIRNNEKYDPIFNFKPEYIISLQLMAMIKHIFNDKVLRLDSNFIDFISWDDDLPESLQIVVDDSTFTGDKILMTSSQFRELKEFHKQSKKVESITNSHASLIPVTELTEIYISPTKLFSRKDYQRLFQPQSTDNTFNNNDPLIQEWIPKSKTLFTSLSFGSSAPTYQEASTEIQACHDWVSISKEQWKQLLYHVLQYIVDEAVKVNSVINEFTECLKQISLDEVIRANSELFLKFSKLNESFLKKFKGASRQDILKLIILFDENVRFCESFESILNQRLKLGKILSIIEVDLDKKKNFLDKLSPGNNNSNNEDLKIRTAEDEYRIVLKRYNRVKQSWEKIMEDILNERKEFEKREAAEVNSCLKSIRDLNMDEKKHYLQLWQDFVPDEHISQ
SIO_010081: YKR078W
subclass of: SO_0000673
so part of: YKR078W
location: 584952..586709
location: region:584952-586709:1
so has part: feature:584952-586709:1:exon

NP_013004.3
type: Protein
SIO_000068: ncbiprotein

S000001786
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584952-586709:1:exon

YKR079C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRZ1
locus tag: YKR079C
so part of: sequence
location: complement(<586789..>589305)
location: region:586789-589305:-1
so has part: feature:586789-589305:-1:exon
subclass of: SO_0000010

853954
type: Gene
SIO_000068: ncbigene

position:586789:-1
position: 586789
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:589305:-1
position: 589305
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586789-589305:-1:exon

YKR079C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRZ1
locus tag: YKR079C
product: tRNase Z
transcript id: NM_001179869.1
SIO_010081: YKR079C
subclass of: SO_0000673
so part of: YKR079C
location: complement(<586789..>589305)
location: region:586789-589305:-1
so has part: feature:586789-589305:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:586789-589305:-1:exon

YKR079C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRZ1
locus tag: YKR079C
EC number: 3.1.26.11
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24249226|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24249226|PMID:14690591|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0034414 tRNA 3'-trailer cleavage, endonucleolytic [PMID:12711671]
experiment: EXISTENCE:direct assay:GO:0042780 tRNA 3'-end processing [PMID:24249226]
experiment: EXISTENCE:direct assay:GO:0042781 3'-tRNA processing endoribonuclease activity [PMID:12711671|PMID:24249226]
experiment: EXISTENCE:direct assay:GO:1990180 mitochondrial tRNA 3'-end processing [PMID:24249226]
experiment: EXISTENCE:mutant phenotype:GO:0034414 tRNA 3'-trailer cleavage, endonucleolytic [PMID:24249226]
experiment: EXISTENCE:mutant phenotype:GO:1990180 mitochondrial tRNA 3'-end processing [PMID:24249226]
note: tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
codon start: 1
product: tRNase Z
translation: MFTFIPITHPTSDTKHPLLLVQSAHGEKYFFGKIGEGSQRSLTENKIRISKLKDIFLTGELNWSDIGGLPGMILTIADQGKSNLVLHYGNDILNYIVSTWRYFVFRFGIDLNDHIMKDKEVYKDKIIAVKSFNVLKNGGEDRLGVFDSFQKGVLRSIVAKMFPKHAPTDRYDPSSDPHLNVELPDLDAKVEVSTNYEISFSPVRGKFKVEEAIKLGVPKGPLFAKLTKGQTITLDNGIVVTPEQVLENERHFAKVLILDIPDDLYLNAFVEKFKDYDCAELGMVYYFLGDEVTINDNLFAFIDIFEKNNYGKVNHMISHNKISPNTISFFGSALTTLKLKALQVNNYNLPKTDRVFSKDFYDRFDTPLSRGTSMCKSQEEPLNTIIEKDNIHIFSQNKTVTFEPFRMNEEPMKCNINGEVADFSWQEIFEEHVKPLEFPLADVDTVINNQLHVDNFNNSAEKKKHVEIITLGTGSALPSKYRNVVSTLVKVPFTDADGNTINRNIMLDAGENTLGTIHRMFSQLAVKSIFQDLKMIYLSHLHADHHLGIISVLNEWYKYNKDDETSYIYVVTPWQYHKFVNEWLVLENKEILKRIKYISCEHFINDSFVRMQTQSVPLAEFNEILKENSNQESNRKLELDRDSSYRDVDLIRQMYEDLSIEYFQTCRAIHCDWAYSNSITFRMDENNEHNTFKVSYSGDTRPNIEKFSLEIGYNSDLLIHEATLENQLLEDAVKKKHCTINEAIGVSNKMNARKLILTHFSQRYPKLPQLDNNIDVMAREFCFAFDSMIVDYEKIGEQQRIFPLLNKAFVEEKEEEEDVDDVESVQDLEVKLKKHKKN
SIO_010081: YKR079C
subclass of: SO_0000673
so part of: YKR079C
location: complement(586789..589305)
location: region:586789-589305:-1
so has part: feature:586789-589305:-1:exon

NP_013005.1
type: Protein
SIO_000068: ncbiprotein

S000001787
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586789-589305:-1:exon

YKR080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTD1
locus tag: YKR080W
so part of: sequence
location: <590395..>591357
location: region:590395-591357:1
so has part: feature:590395-591357:1:exon
subclass of: SO_0000010

853955
type: Gene
SIO_000068: ncbigene

position:590395:1
position: 590395
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:591357:1
position: 591357
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:590395-591357:1:exon

YKR080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTD1
locus tag: YKR080W
product: methylenetetrahydrofolate dehydrogenase (NAD(+))
transcript id: NM_001179870.3
SIO_010081: YKR080W
subclass of: SO_0000673
so part of: YKR080W
location: <590395..>591357
location: region:590395-591357:1
so has part: feature:590395-591357:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:590395-591357:1:exon

YKR080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTD1
locus tag: YKR080W
EC number: 1.5.1.15
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8608153]
experiment: EXISTENCE:direct assay:GO:0006730 one-carbon metabolic process [PMID:8608153]
experiment: EXISTENCE:direct assay:GO:0009113 purine nucleobase biosynthetic process [PMID:8608153]
experiment: EXISTENCE:mutant phenotype:GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity [PMID:8416923]
experiment: EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:8608153]
experiment: EXISTENCE:mutant phenotype:GO:0009113 purine nucleobase biosynthetic process [PMID:8608153]
experiment: EXISTENCE:mutant phenotype:GO:0009396 folic acid-containing compound biosynthetic process [PMID:8608153]
note: NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
codon start: 1
product: methylenetetrahydrofolate dehydrogenase (NAD(+))
translation: MSKPGRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGFRYDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFSDDVKEKASLYVPMTGKVTIAMLLRNMLRLVRNVELSKEK
SIO_010081: YKR080W
subclass of: SO_0000673
so part of: YKR080W
location: 590395..591357
location: region:590395-591357:1
so has part: feature:590395-591357:1:exon

NP_013006.3
type: Protein
SIO_000068: ncbiprotein

S000001788
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:590395-591357:1:exon

YKR081C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPF2
locus tag: YKR081C
so part of: sequence
location: complement(<591506..>592540)
location: region:591506-592540:-1
so has part: feature:591506-592540:-1:exon
subclass of: SO_0000010

853956
type: Gene
SIO_000068: ncbigene

position:591506:-1
position: 591506
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592540:-1
position: 592540
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:591506-592540:-1:exon

YKR081C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPF2
locus tag: YKR081C
product: rRNA-binding ribosome biosynthesis protein RPF2
transcript id: NM_001179871.1
SIO_010081: YKR081C
subclass of: SO_0000673
so part of: YKR081C
location: complement(<591506..>592540)
location: region:591506-592540:-1
so has part: feature:591506-592540:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:591506-592540:-1:exon

YKR081C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPF2
locus tag: YKR081C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:25855814|PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0008097 5S rRNA binding [PMID:25855814]
experiment: EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]
note: Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
codon start: 1
product: rRNA-binding ribosome biosynthesis protein RPF2
translation: MIRTVKPKNARAKRALVKREAKLVENVKQALFIPGQSCNKNLHDIMVDLSALKKPDMKRFNRKNDIHPFEDMSPLEFFSEKNDCSLMVLMTSSKKRKNNMTFIRTFGYKIYDMIELMVADNFKLLSDFKKLTFTVGLKPMFTFQGAAFDTHPVYKQIKSLFLDFFRGESTDLQDVAGLQHVISMTIQGDFQDGEPLPNVLFRVYKLKSYKSDQGGKRLPRIELVEIGPRLDFKIGRIHTPSPDMVTEAHKKPKQLEMKTKKNVELDIMGDKLGRIHMGKQDLGKLQTRKMKGLKSKFDQGTEEGDGEVDEDYEDEASYSDDGQEYEEEFVSATDIEPSAKRQKK
SIO_010081: YKR081C
subclass of: SO_0000673
so part of: YKR081C
location: complement(591506..592540)
location: region:591506-592540:-1
so has part: feature:591506-592540:-1:exon

NP_013007.1
type: Protein
SIO_000068: ncbiprotein

S000001789
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:591506-592540:-1:exon

YKR082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RAT3
gene: NUP133
locus tag: YKR082W
gene synonym: RAT3
so part of: sequence
location: <592825..>596298
location: region:592825-596298:1
so has part: feature:592825-596298:1:exon
subclass of: SO_0000010

853957
type: Gene
SIO_000068: ncbigene

position:592825:1
position: 592825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:596298:1
position: 596298
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:592825-596298:1:exon

YKR082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RAT3
gene: NUP133
locus tag: YKR082W
gene synonym: RAT3
product: Nup133p
transcript id: NM_001179872.3
SIO_010081: YKR082W
subclass of: SO_0000673
so part of: YKR082W
location: <592825..>596298
location: region:592825-596298:1
so has part: feature:592825-596298:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:592825-596298:1:exon

YKR082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RAT3
gene: NUP133
locus tag: YKR082W
gene synonym: RAT3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:18046406|PMID:11823431]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]
experiment: EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22110603]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532|PMID:17538013]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7813444|PMID:21036941]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:22331846|PMID:7813444|PMID:7862658|PMID:9725905]
note: Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133
codon start: 1
product: Nup133p
translation: MSEKKVHLRLRKELSVPIAVVENESLAQLSYEEESQASLMDISMEQQQLRLHSHFDNSKVFTENNRYIVKTLQTDYSSGFSNDDELNGYIDMQIGYGLVNDHKKVYIWNIHSTQKDTPYITVPFRSDDNDEIAVAPRCILTFPATMDESPLALNPNDQDETGGLIIIKGSKAIYYEDINSINNLNFKLSEKFSHELELPINSSGGEKCDLMLNCEPAGIVLSTNMGRIFFITIRNSMGKPQLKLGKLLNKPFKLGIWSKIFNTNSSVVSLRNGPILGKGTRLVYITTNKGIFQTWQLSATNSHPTKLIDVNIYEAILESLQDLYPFAHGTLKIWDSHPLQDESSQLFLSSIYDSSCNETYYILSTIIFDSSSNSFTIFSTYRLNTFMESITDTKFKPKIFIPQMENANDTNEVTSILVMFPNAVVITQVNSKLDSSYSMRRKWEDIVSLRNDIDIIGSGYDSKSLYVLTKQMGVLQFFVKENEETNSKPEVGFVKSHVDQAVYFSKINANPIDFNLPPEISLDQESIEHDLKLTSEEIFHSNGKYIPPMLNTLGQHLSVRKEFFQNFLTFVAKNFNYKISPELKLDLIEKFEILNCCIKFNSIIRQSDVLNDIWEKTLSNYNLTQNEHLTTKTVVINSPDVFPVIFKQFLNHVVFVLFPSQNQNFKLNVTNLINLCFYDGILEEGEKTIRYELLELDPMEVDTSKLPWFINFDYLNCINQCFFDFTFACEEEGSLDSYKEGLLKIVKILYYQFNQFKIWINTQPVKSVNANDNFININNLYDDNHLDWNHVLCKVNLKEQCIQIAEFYKDLSGLVQTLQTLDQNDSTTVSLYETFFNEFPKEFSFTLFEYLIKHKKLNDLIFRFPQQHDVLIQFFQESAPKYGHVAWIQQILDGSYADAMNTLKNITVDDSKKGESLSECELHLNVAKLSSLLVEKDNLDINTLRKIQYNLDTIDAEKNISNKLKKGEVQICKRFKNGSIREVFNILVEELKSTTVVNLSDLVELYSMLDDEESLFIPLRLLSVDGNLLNFEVKKFLNALVWRRIVLLNASNEGDKLLQHIVKRVFDEELPKNNDFPLPSVDLLCDKSLLTPEYISETYGRFPIDQNAIREEIYEEISQVETLNSDNSLEIKLHSTIGSVAKEKNYTINYETNTVEY
SIO_010081: YKR082W
subclass of: SO_0000673
so part of: YKR082W
location: 592825..596298
location: region:592825-596298:1
so has part: feature:592825-596298:1:exon

NP_013008.3
type: Protein
SIO_000068: ncbiprotein

S000001790
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:592825-596298:1:exon

YKR083C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HSK1
gene: DAD2
locus tag: YKR083C
gene synonym: HSK1
so part of: sequence
location: complement(<596421..>596822)
location: region:596421-596822:-1
so has part: feature:596421-596822:-1:exon
subclass of: SO_0000010

853958
type: Gene
SIO_000068: ncbigene

position:596421:-1
position: 596421
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:596822:-1
position: 596822
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:596421-596822:-1:exon

YKR083C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HSK1
gene: DAD2
locus tag: YKR083C
gene synonym: HSK1
product: Dad2p
transcript id: NM_001179873.1
SIO_010081: YKR083C
subclass of: SO_0000673
so part of: YKR083C
location: complement(<596421..>596822)
location: region:596421-596822:-1
so has part: feature:596421-596822:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:596421-596822:-1:exon

YKR083C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HSK1
gene: DAD2
locus tag: YKR083C
gene synonym: HSK1
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
codon start: 1
product: Dad2p
translation: MDSIDEQIAIKRKELQSLQKITSLTDGLKIQLTELNEQIKEMGMNADSVAQLMNNWDSIINNISQASLGLLQYAEGDYEIGPWKDSKKKESEQSNETGLEAQENDKNDEDNDEDEDLVPLPETMVRIRVDGNE
SIO_010081: YKR083C
subclass of: SO_0000673
so part of: YKR083C
location: complement(596421..596822)
location: region:596421-596822:-1
so has part: feature:596421-596822:-1:exon

NP_013009.1
type: Protein
SIO_000068: ncbiprotein

S000001791
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:596421-596822:-1:exon

YKR084C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HBS1
locus tag: YKR084C
so part of: sequence
location: complement(<597055..>598890)
location: region:597055-598890:-1
so has part: feature:597055-598890:-1:exon
subclass of: SO_0000010

853959
type: Gene
SIO_000068: ncbigene

position:597055:-1
position: 597055
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:598890:-1
position: 598890
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:597055-598890:-1:exon

YKR084C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HBS1
locus tag: YKR084C
product: ribosome dissociation factor GTPase HBS1
transcript id: NM_001179874.3
SIO_010081: YKR084C
subclass of: SO_0000673
so part of: YKR084C
location: complement(<597055..>598890)
location: region:597055-598890:-1
so has part: feature:597055-598890:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:597055-598890:-1:exon

YKR084C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HBS1
locus tag: YKR084C
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:20947765]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:20947765]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21623367]
experiment: EXISTENCE:direct assay:GO:1990533 Dom34-Hbs1 complex [PMID:21623367]
experiment: EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:16554824]
experiment: EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]
note: GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication
codon start: 1
product: ribosome dissociation factor GTPase HBS1
translation: MAYSDYSDGADDMPDFHDEGEFDDYLNDDEYDLMNEVFPTLKAQLQDYQGWDNLSLKLALFDNNFDLESTLAELKKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLPDWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKPKKPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQRFEEIKSKLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLEIIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPGTPFILFIGVKEQPARIKRLISFIDKGNTASKKKIRHLGSKQRAFVEIELIEVKRWIPLLTAHENDRLGRVVLRKDGRTIAAGKISEITQ
SIO_010081: YKR084C
subclass of: SO_0000673
so part of: YKR084C
location: complement(597055..598890)
location: region:597055-598890:-1
so has part: feature:597055-598890:-1:exon

NP_013010.3
type: Protein
SIO_000068: ncbiprotein

S000001792
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:597055-598890:-1:exon

YKR085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mL58
gene: MRPL20
locus tag: YKR085C
gene synonym: mL58
so part of: sequence
location: complement(<599094..>599681)
location: region:599094-599681:-1
so has part: feature:599094-599681:-1:exon
subclass of: SO_0000010

853960
type: Gene
SIO_000068: ncbigene

position:599094:-1
position: 599094
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:599681:-1
position: 599681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599094-599681:-1:exon

YKR085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mL58
gene: MRPL20
locus tag: YKR085C
gene synonym: mL58
product: mitochondrial 54S ribosomal protein YmL20
transcript id: NM_001179875.1
SIO_010081: YKR085C
subclass of: SO_0000673
so part of: YKR085C
location: complement(<599094..>599681)
location: region:599094-599681:-1
so has part: feature:599094-599681:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:599094-599681:-1:exon

YKR085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mL58
gene: MRPL20
locus tag: YKR085C
gene synonym: mL58
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL20
translation: MIGRGVCCRSFHTAGSAWKQFGFPKTQVTTIYNKTKSASNYKGYLKHRDAPGMYYQPSESIATGSVNSETIPRSFMAASDPRRGLDMPVQSTKAKQCPNVLVGKSTVNGKTYHLGPQEIDEIRKLRLDNPQKYTRKFLAAKYGISPLFVSMVSKPSEQHVQIMESRLQEIQSRWKEKRRIAREDRKRRKLLWYQA
SIO_010081: YKR085C
subclass of: SO_0000673
so part of: YKR085C
location: complement(599094..599681)
location: region:599094-599681:-1
so has part: feature:599094-599681:-1:exon

NP_013011.1
type: Protein
SIO_000068: ncbiprotein

S000001793
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:599094-599681:-1:exon

YKR086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PRP23
alternative label: RNA16
gene: PRP16
locus tag: YKR086W
gene synonym: PRP23; RNA16
so part of: sequence
location: <599857..>603072
location: region:599857-603072:1
so has part: feature:599857-603072:1:exon
subclass of: SO_0000010

853961
type: Gene
SIO_000068: ncbigene

position:599857:1
position: 599857
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:603072:1
position: 603072
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599857-603072:1:exon

YKR086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PRP23
alternative label: RNA16
gene: PRP16
locus tag: YKR086W
gene synonym: PRP23; RNA16
product: DEAH-box RNA helicase PRP16
transcript id: NM_001179876.3
SIO_010081: YKR086W
subclass of: SO_0000673
so part of: YKR086W
location: <599857..>603072
location: region:599857-603072:1
so has part: feature:599857-603072:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:599857-603072:1:exon

YKR086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PRP23
alternative label: RNA16
gene: PRP16
locus tag: YKR086W
gene synonym: PRP23; RNA16
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000378 RNA exon ligation [PMID:23685439]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:1825134]
experiment: EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:1825134]
experiment: EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:16103217|PMID:1825134]
experiment: EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:1825134]
experiment: EXISTENCE:mutant phenotype:GO:0016073 snRNA metabolic process [PMID:19458033]
experiment: EXISTENCE:mutant phenotype:GO:0040031 snRNA modification [PMID:19458033]
note: DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa
codon start: 1
product: DEAH-box RNA helicase PRP16
translation: MGHSGREERIKDIFKELTSKELTPGLLLTLQKLAQKPNTNLEQFIASCKALTKLSSNNPIIFNELLELLKNKSEEDSTGPKKIAPSINKRKKFKIQLDLDDNEDELDSPVQKKPAPTRTLFKRIDKLKAKQLRQYSPTVKDPSPNSEQQTQNGHAETKDYEPTRSEVVEEDREWYDNDDDYGNLVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVALRRINMEHIQQSRDNTTVLNTAMGEVLGLENNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKSQKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVYHELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKNDQEATTTGLFGEHYEHTLDKVEDDIDINIRRCKDMRDSVIQELKMTDNSNKEDKKQKTKKQNILNGKENSMKPFKRRKPFF
SIO_010081: YKR086W
subclass of: SO_0000673
so part of: YKR086W
location: 599857..603072
location: region:599857-603072:1
so has part: feature:599857-603072:1:exon

NP_013012.3
type: Protein
SIO_000068: ncbiprotein

S000001794
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:599857-603072:1:exon

YKR087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OMA1
locus tag: YKR087C
so part of: sequence
location: complement(<603195..>604232)
location: region:603195-604232:-1
so has part: feature:603195-604232:-1:exon
subclass of: SO_0000010

853962
type: Gene
SIO_000068: ncbigene

position:603195:-1
position: 603195
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:604232:-1
position: 604232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:603195-604232:-1:exon

YKR087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OMA1
locus tag: YKR087C
product: metalloendopeptidase
transcript id: NM_001179877.1
SIO_010081: YKR087C
subclass of: SO_0000673
so part of: YKR087C
location: complement(<603195..>604232)
location: region:603195-604232:-1
so has part: feature:603195-604232:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:603195-604232:-1:exon

YKR087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OMA1
locus tag: YKR087C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12963738]
experiment: EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:12963738]
experiment: EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:12963738]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:27325672]
experiment: EXISTENCE:mutant phenotype:GO:0035694 mitochondrial protein catabolic process [PMID:27325672]
experiment: EXISTENCE:mutant phenotype:GO:0051775 response to redox state [PMID:31044600]
note: Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability
codon start: 1
product: metalloendopeptidase
translation: MLRNIIRFKGFGKGTSGGFLKPVSFRVQLTRCYRYDNGPSYRRFNNGEYSQKSSFKSILLDKSSRKYLALLFGGCSLFYYTHLDKAPVSDRSRFIWVSRPLELTIGNYTYKSIWRQTQQEILPPQHPLSIKIENIFMKIVEAAYKDPSVDNSLLDGIKWEIHVVNDPTASPNAFVLPGGKVFIFSSILPICANDDGIATVLAHEFAHQLARHTAENLSKAPIYSLLGLVLYTVTGAHAINNILLDGFLRMPASRQMETEADYIGLMIMSRACFQPQESIKVWERMANFEKQMNRGGVVNMEFLSTHPASTRRIENMSKWLPKANEIYEQSDCSSMGNYYKSFFSM
SIO_010081: YKR087C
subclass of: SO_0000673
so part of: YKR087C
location: complement(603195..604232)
location: region:603195-604232:-1
so has part: feature:603195-604232:-1:exon

NP_013013.2
type: Protein
SIO_000068: ncbiprotein

S000001795
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:603195-604232:-1:exon

YKR088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TVP38
locus tag: YKR088C
so part of: sequence
location: complement(<604405..>605418)
location: region:604405-605418:-1
so has part: feature:604405-605418:-1:exon
subclass of: SO_0000010

853963
type: Gene
SIO_000068: ncbigene

position:604405:-1
position: 604405
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:605418:-1
position: 605418
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:604405-605418:-1:exon

YKR088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TVP38
locus tag: YKR088C
product: Tvp38p
transcript id: NM_001179878.3
SIO_010081: YKR088C
subclass of: SO_0000673
so part of: YKR088C
location: complement(<604405..>605418)
location: region:604405-605418:-1
so has part: feature:604405-605418:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:604405-605418:-1:exon

YKR088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TVP38
locus tag: YKR088C
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]
experiment: EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:18194531]
note: Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
codon start: 1
product: Tvp38p
translation: MSQSYEAGNANMGQGEDDEFDGYFEDFDNDIMPNSNNGQRVGTNAGLSFNDEVNVNDDDFLDIYNMSPRERLMHNIRKNVQKLQFYFYSLRLWQQIIIVLLGIMLMIMGILLLVFHNAILHKVVVTSNDLREKMSTHFILMVLIFFVAFPPMIGYSLLSTTTGLIYGVSFEGWVTLALGSVTGSIASFVVFKTILHSRAEKLVHLNRRFEALASILQENNSYWILALLRLCPFPYSLTNGAIAGVYGISVRNFSIANIITTPKLFIYLFIGSRVKSLAESESTGSRVFDLVSIIITLLILSLTAWLLYFKTKKRYLELQNRDRQVSTDQLPELSFEV
SIO_010081: YKR088C
subclass of: SO_0000673
so part of: YKR088C
location: complement(604405..605418)
location: region:604405-605418:-1
so has part: feature:604405-605418:-1:exon

NP_013014.3
type: Protein
SIO_000068: ncbiprotein

S000001796
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:604405-605418:-1:exon

YKR089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: STC1
gene: TGL4
locus tag: YKR089C
gene synonym: STC1
so part of: sequence
location: complement(<605633..>608365)
location: region:605633-608365:-1
so has part: feature:605633-608365:-1:exon
subclass of: SO_0000010

853964
type: Gene
SIO_000068: ncbigene

position:605633:-1
position: 605633
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:608365:-1
position: 608365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:605633-608365:-1:exon

YKR089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: STC1
gene: TGL4
locus tag: YKR089C
gene synonym: STC1
product: triacylglycerol lipase
transcript id: NM_001179879.1
SIO_010081: YKR089C
subclass of: SO_0000673
so part of: YKR089C
location: complement(<605633..>608365)
location: region:605633-608365:-1
so has part: feature:605633-608365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:605633-608365:-1:exon

YKR089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: STC1
gene: TGL4
locus tag: YKR089C
gene synonym: STC1
EC number: 3.1.1.3
experiment: EXISTENCE:direct assay:GO:0004771 sterol esterase activity [PMID:20332534]
experiment: EXISTENCE:direct assay:GO:0004806 triglyceride lipase activity [PMID:16135509|PMID:20332534]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:16135509|PMID:16267052|PMID:24868093|PMID:14562095|P MID:24390141]
experiment: EXISTENCE:direct assay:GO:0006642 triglyceride mobilization [PMID:16135509]
experiment: EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:20332534]
experiment: EXISTENCE:direct assay:GO:0047499 calcium-independent phospholipase A2 activity [PMID:20332534]
experiment: EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:19150427]
experiment: EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:16267052]
experiment: EXISTENCE:mutant phenotype:GO:0004771 sterol esterase activity [PMID:20332534]
experiment: EXISTENCE:mutant phenotype:GO:0004806 triglyceride lipase activity [PMID:16135509|PMID:20332534]
experiment: EXISTENCE:mutant phenotype:GO:0006642 triglyceride mobilization [PMID:16135509]
experiment: EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:20332534]
experiment: EXISTENCE:mutant phenotype:GO:0007114 cell budding [PMID:19150427]
experiment: EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:16267052]
experiment: EXISTENCE:mutant phenotype:GO:0047499 calcium-independent phospholipase A2 activity [PMID:20332534]
note: Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication
codon start: 1
product: triacylglycerol lipase
translation: MSSKISDLTSTQNKPLLVTQQLIEKYYEQILGTSQNIIPILNPKNKFIRPSKDNSDVERVEEDAGKRLQTGKNKTTNKVNFNLDTGNEDKLDDDQETVTENENNDIEMVETDEGEDERQGSSLASKCKSFLYNVFVGNYERDILIDKVCSQKQHAMSFEEWCSAGARLDDLTGKTEWKQKLESPLYDYKLIKDLTSRMREERLNRNYAQLLYIIRTNWVRNLGNMGNVNLYRHSHVGTKYLIDEYMMESRLALESLMESDLDDSYLLGILQQTRRNIGRTALVLSGGGTFGLFHIGVLGTLFELDLLPRVISGSSAGAIVASILSVHHKEEIPVLLNHILDKEFNIFKDDKQKSESENLLIKISRFFKNGTWFDNKHLVNTMIEFLGDLTFREAYNRTGKILNITVSPASLFEQPRLLNNLTAPNVLIWSAVCASCSLPGIFPSSPLYEKDPKTGERKPWTGSSSVKFVDGSVDNDLPISRLSEMFNVDHIIACQVNIHVFPFLKLSLSCVGGEIEDEFSARLKQNLSSIYNFMANEAIHILEIGSEMGIAKNALTKLRSVLSQQYSGDITILPDMCMLFRIKELLSNPTKEFLLREITNGAKATWPKVSIIQNHCGQEFALDKAISYIKGRMIVTSSLKTPFQFADSVIGLIKAPEQTSDESKNPENSTLLTRTPTKGDNHISNVLDDNLLESESTNSLLLLRENASTYGRSPSGFRPRYSITSASLNPRHQRRKSDTISTSRRPAKSFSFSVASPTSRMLRQSSKINGHPPPILQKKTSMGRLMFPMDAKTYDPESHELIPHSASIETPAMVDKKLHFGRKSRYLRHMNKKWVSSSNILYTDSDKEDHPTLRLISNFDSDAMIHSDLAGNFRRHSIDGRPPSQATKSSPFRSRPSSSTQHKSTTSFTQ
SIO_010081: YKR089C
subclass of: SO_0000673
so part of: YKR089C
location: complement(605633..608365)
location: region:605633-608365:-1
so has part: feature:605633-608365:-1:exon

NP_013015.1
type: Protein
SIO_000068: ncbiprotein

S000001797
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:605633-608365:-1:exon

YKR090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PXL1
locus tag: YKR090W
so part of: sequence
location: <608946..>611066
location: region:608946-611066:1
so has part: feature:608946-611066:1:exon
subclass of: SO_0000010

853965
type: Gene
SIO_000068: ncbigene

position:608946:1
position: 608946
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611066:1
position: 611066
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:608946-611066:1:exon

YKR090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PXL1
locus tag: YKR090W
product: Pxl1p
transcript id: NM_001179880.4
SIO_010081: YKR090W
subclass of: SO_0000673
so part of: YKR090W
location: <608946..>611066
location: region:608946-611066:1
so has part: feature:608946-611066:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:608946-611066:1:exon

YKR090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PXL1
locus tag: YKR090W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14767053]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23613772|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:14767053|PMID:15282802|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14767053|PMID:15282802|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23613772]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:14767053]
experiment: EXISTENCE:genetic interaction:GO:0005094 Rho GDP-dissociation inhibitor activity [PMID:15215315]
experiment: EXISTENCE:genetic interaction:GO:0035023 regulation of Rho protein signal transduction [PMID:15215315]
experiment: EXISTENCE:mutant phenotype:GO:0030011 maintenance of cell polarity [PMID:14767053]
experiment: EXISTENCE:physical interaction:GO:0035023 regulation of Rho protein signal transduction [PMID:15215315]
note: Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
codon start: 1
product: Pxl1p
translation: MYNSIYGSPFPKINPKVRYKTALERAGFDTKPRNPFSSQRNASTGSLQASVKSPPITRQRNVSAAPSVPVTMKSAYTASSKSAYSSVKGESDIYPPPVLENSERRSVTPPKNSNFTSSRPSDISRSISRPSERASQEDPFRFERDLDRQAEQYAASRHTCKSPANKEFQAADNFPFNFEQEDAGNTEREQDLSPIERSFMMLTQNDTASVVNSMNQTDNRGVLDQKLGKEQQKEESSIEYESEGQQEDENDIESLNFEPDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLTMNALDSKIYPDDNFSGLESSKEQKSPGVSSSSTKVEDLSLDGLNEKRLSITSSENVETPYTATNLQVEQLIAQLDDVSLSRNAKLDMNGNCLNAVDRKASRFKKSSAYLSGYPSMDIPVTQQTSIVQNSNTNLSRQTILVDKGDVDEDAPSESTTNGGTPIFYKFKQSNVEYSNNEGMGSQETFRTKLPTIEALQLQHKRNITDLREEIDNSKSNDSHVLPNGGTTRYSSDADYKETEPIEFKYPPGEGPCRACGLEVTGKRMFSKKENELSGQWHRECFKCIECGIKFNKHVPCYILGDEPYCQKHYHEENHSICKVCSNFIEGECLENDKVERFHVDCLNCFLCKTAITNDYYIFNGEIPLCGNHDMEALLKEGIDNATSSNDKNNTLSKRRTRLINFN
SIO_010081: YKR090W
subclass of: SO_0000673
so part of: YKR090W
location: 608946..611066
location: region:608946-611066:1
so has part: feature:608946-611066:1:exon

NP_013016.4
type: Protein
SIO_000068: ncbiprotein

S000001798
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:608946-611066:1:exon

YKR091W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: WHI7
gene: SRL3
locus tag: YKR091W
gene synonym: WHI7
so part of: sequence
location: <611525..>612265
location: region:611525-612265:1
so has part: feature:611525-612265:1:exon
subclass of: SO_0000010

853966
type: Gene
SIO_000068: ncbigene

position:611525:1
position: 611525
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:612265:1
position: 612265
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611525-612265:1:exon

YKR091W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: WHI7
gene: SRL3
locus tag: YKR091W
gene synonym: WHI7
product: DNA-binding protein SRL3
transcript id: NM_001179881.1
SIO_010081: YKR091W
subclass of: SO_0000673
so part of: YKR091W
location: <611525..>612265
location: region:611525-612265:1
so has part: feature:611525-612265:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611525-612265:1:exon

YKR091W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: WHI7
gene: SRL3
locus tag: YKR091W
gene synonym: WHI7
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:23382076]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:9744871]
note: Repressor of transcription at Start; binds to SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; inhibitor of Start that retains Cdc28-Cln3 at the ER; acts with Ydj1p to promote release of the complex in a growth-mediated positive feedback loop to trigger Start; Srl3p is unstable and degraded by SCF-Grr1 after Cdc28p-dependent phosphorylation; contains a GTB (G1/S transcription factor binding) motif; binds SBF-regulated promoters in HU-treated cells; Cdc28p substrate
codon start: 1
product: DNA-binding protein SRL3
translation: MFLKTPNWETVNETPKSRVLTINELISPNLDTESNSLLATPARKYFKTSISEAQDSPTSAPSPDGNEDPTYQYNVQFHFPGPITPTTPRSKNAEMFPSPTPPLVSPTAVIEEENDDSVREFSRTLKSRLNCAMVKLSKEHEQVALIPPPPTEKIRKGSYSNKFAAKHRRCHSLDESKKFLSSLEDSSAHAAFLKAISSKHAKSNRVDNVNVSPLRWSSHRRTQSTQENSLQEVVAIDTLLKMSSSD
SIO_010081: YKR091W
subclass of: SO_0000673
so part of: YKR091W
location: 611525..612265
location: region:611525-612265:1
so has part: feature:611525-612265:1:exon

NP_013017.2
type: Protein
SIO_000068: ncbiprotein

S000001799
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611525-612265:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1120; Autonomously Replicating Sequence
so part of: sequence
location: 612378..612463
location: region:612378-612463:1
so has part: feature:612378-612463:1:region

S000118409
type: SGD
SIO_000068: sgd

position:612378:1
position: 612378
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:612463:1
position: 612463
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:612378-612463:1:region

YKR092C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRP40
locus tag: YKR092C
so part of: sequence
location: complement(<612665..>613885)
location: region:612665-613885:-1
so has part: feature:612665-613885:-1:exon
subclass of: SO_0000010

853967
type: Gene
SIO_000068: ncbigene

position:612665:-1
position: 612665
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:613885:-1
position: 613885
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:612665-613885:-1:exon

YKR092C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SRP40
locus tag: YKR092C
product: Srp40p
transcript id: NM_001179882.3
SIO_010081: YKR092C
subclass of: SO_0000673
so part of: YKR092C
location: complement(<612665..>613885)
location: region:612665-613885:-1
so has part: feature:612665-613885:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:612665-613885:-1:exon

YKR092C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SRP40
locus tag: YKR092C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8702624]
note: Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
codon start: 1
product: Srp40p
translation: MASKKIKVDEVPKLSVKEKEIEEKSSSSSSSSSSSSSSSSSSSSSSSSSGESSSSSSSSSSSSSSDSSDSSDSESSSSSSSSSSSSSSSSDSESSSESDSSSSGSSSSSSSSSDESSSESESEDETKKRARESDNEDAKETKKAKTEPESSSSSESSSSGSSSSSESESGSESDSDSSSSSSSSSDSESDSESDSQSSSSSSSSDSSSDSDSSSSDSSSDSDSSSSSSSSSSDSDSDSDSSSDSDSSGSSDSSSSSDSSSDESTSSDSSDSDSDSDSGSSSELETKEATADESKAEETPASSNESTPSASSSSSANKLNIPAGTDEIKEGQRKHFSRVDRSKINFEAWELTDNTYKGAAGTWGEKANEKLGRVRGKDFTKNKNKMKRGSYRGGSITLESGSYKFQD
SIO_010081: YKR092C
subclass of: SO_0000673
so part of: YKR092C
location: complement(612665..613885)
location: region:612665-613885:-1
so has part: feature:612665-613885:-1:exon

NP_013018.3
type: Protein
SIO_000068: ncbiprotein

S000001800
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:612665-613885:-1:exon

YKR093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTR2
locus tag: YKR093W
so part of: sequence
location: <615730..>617535
location: region:615730-617535:1
so has part: feature:615730-617535:1:exon
subclass of: SO_0000010

853968
type: Gene
SIO_000068: ncbigene

position:615730:1
position: 615730
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:617535:1
position: 617535
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:615730-617535:1:exon

YKR093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTR2
locus tag: YKR093W
product: Ptr2p
transcript id: NM_001179883.1
SIO_010081: YKR093W
subclass of: SO_0000673
so part of: YKR093W
location: <615730..>617535
location: region:615730-617535:1
so has part: feature:615730-617535:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:615730-617535:1:exon

YKR093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTR2
locus tag: YKR093W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:17507646]
experiment: EXISTENCE:direct assay:GO:0042937 tripeptide transmembrane transporter activity [PMID:16096264]
experiment: EXISTENCE:direct assay:GO:0042938 dipeptide transport [PMID:16096264]
experiment: EXISTENCE:direct assay:GO:0042939 tripeptide transport [PMID:16096264]
experiment: EXISTENCE:direct assay:GO:0071916 dipeptide transmembrane transporter activity [PMID:16096264]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015833 peptide transport [PMID:8264579]
experiment: EXISTENCE:mutant phenotype:GO:1904680 peptide transmembrane transporter activity [PMID:8264579]
note: Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway
codon start: 1
product: Ptr2p
translation: MLNHPSQGSDDAQDEKQGDFPVIEEEKTQAVTLKDSYVSDDVANSTERYNLSPSPEDEDFEGPTEEEMQTLRHVGGKIPMRCWLIAIVELSERFSYYGLSAPFQNYMEYGPNDSPKGVLSLNSQGATGLSYFFQFWCYVTPVFGGYVADTFWGKYNTICCGTAIYIAGIFILFITSIPSVGNRDSAIGGFIAAIILIGIATGMIKANLSVLIADQLPKRKPSIKVLKSGERVIVDSNITLQNVFMFFYFMINVGSLSLMATTELEYHKGFWAAYLLPFCFFWIAVVTLIFGKKQYIQRPIGDKVIAKSFKVCWILTKNKFDFNAAKPSVHPEKNYPWNDKFVDEIKRALAACKVFIFYPIYWTQYGTMISSFITQASMMELHGIPNDFLQAFDSIALIIFIPIFEKFVYPFIRRYTPLKPITKIFFGFMFGSFAMTWAAVLQSFVYKAGPWYNEPLGHNTPNHVHVCWQIPAYVLISFSEIFASITGLEYAYSKAPASMKSFIMSIFLLTNAFGSAIGCALSPVTVDPKFTWLFTGLAVACFISGCLFWLCFRKYNDTEEEMNAMDYEEEDEFDLNPISAPKANDIEILEPMESLRSTTKY
SIO_010081: YKR093W
subclass of: SO_0000673
so part of: YKR093W
location: 615730..617535
location: region:615730-617535:1
so has part: feature:615730-617535:1:exon

NP_013019.1
type: Protein
SIO_000068: ncbiprotein

S000001801
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:615730-617535:1:exon

YKR094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CEP52B
alternative label: UB12
alternative label: UBI2
gene: RPL40B
locus tag: YKR094C
gene synonym: CEP52B; UB12; UBI2
so part of: sequence
location: complement(<617996..>618750)
location: region:617996-618750:-1
so has part: feature:617996-618750:-1:exon
subclass of: SO_0000010

853969
type: Gene
SIO_000068: ncbigene

position:617996:-1
position: 617996
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:618750:-1
position: 618750
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:617996-618750:-1:exon

YKR094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CEP52B
alternative label: UB12
alternative label: UBI2
gene: RPL40B
locus tag: YKR094C
gene synonym: CEP52B; UB12; UBI2
product: ubiquitin-ribosomal 60S subunit protein L40B fusion protein
transcript id: NM_001179884.3
SIO_010081: YKR094C
subclass of: SO_0000673
so part of: YKR094C
location: complement(join(<617996..618374,618743..>618750))
location: region:617996-618750:-1
so has part: feature:618743-618750:-1:exon
so has part: feature:617996-618374:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:618743-618750:-1:exon

position:618743:-1
position: 618743
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:617996-618374:-1:exon

position:618374:-1
position: 618374
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YKR094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CEP52B
alternative label: UB12
alternative label: UBI2
gene: RPL40B
locus tag: YKR094C
gene synonym: CEP52B; UB12; UBI2
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:2538753]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:22995916]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:22995916]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8035826]
note: Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-ribosomal 60S subunit protein L40B fusion protein
translation: MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCDKSVCRKCYARLPPRATNCRKRKCGHTNQLRPKKKLK
SIO_010081: YKR094C
subclass of: SO_0000673
so part of: YKR094C
location: complement(join(617996..618374,618743..618750))
location: region:617996-618750:-1
so has part: feature:618743-618750:-1:exon
so has part: feature:617996-618374:-1:exon

NP_013020.3
type: Protein
SIO_000068: ncbiprotein

S000001802
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:618743-618750:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:617996-618374:-1:exon

YKR095W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MPL1
gene: MLP1
locus tag: YKR095W
gene synonym: MPL1
so part of: sequence
location: <619805..>625432
location: region:619805-625432:1
so has part: feature:619805-625432:1:exon
subclass of: SO_0000010

853970
type: Gene
SIO_000068: ncbigene

position:619805:1
position: 619805
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:625432:1
position: 625432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:619805-625432:1:exon

YKR095W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MPL1
gene: MLP1
locus tag: YKR095W
gene synonym: MPL1
product: Mlp1p
transcript id: NM_001179885.1
SIO_010081: YKR095W
subclass of: SO_0000673
so part of: YKR095W
location: <619805..>625432
location: region:619805-625432:1
so has part: feature:619805-625432:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:619805-625432:1:exon

YKR095W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MPL1
gene: MLP1
locus tag: YKR095W
gene synonym: MPL1
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10085285]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10085285]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16027220]
experiment: EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:24152732]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:10085285]
experiment: EXISTENCE:genetic interaction:GO:0034398 telomere tethering at nuclear periphery [PMID:10638763]
experiment: EXISTENCE:genetic interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:14718167]
experiment: EXISTENCE:genetic interaction:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:21036941]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:14718167]
experiment: EXISTENCE:mutant phenotype:GO:0090204 protein localization to nuclear pore [PMID:19933151]
experiment: EXISTENCE:mutant phenotype:GO:0140586 promoter-terminator loop anchoring activity [PMID:19933151]
experiment: EXISTENCE:physical interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]
note: Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication
codon start: 1
product: Mlp1p
translation: MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDLCRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTDEKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHSSIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQRQIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKLRAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPPKSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQNDNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRNVQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTEDEEEKETDKVNDENSI
SIO_010081: YKR095W
subclass of: SO_0000673
so part of: YKR095W
location: 619805..625432
location: region:619805-625432:1
so has part: feature:619805-625432:1:exon

NP_013021.1
type: Protein
SIO_000068: ncbiprotein

S000001803
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:619805-625432:1:exon

YKR095W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCC1
locus tag: YKR095W-A
so part of: sequence
location: <625864..>626205
location: region:625864-626205:1
so has part: feature:625864-626205:1:exon
subclass of: SO_0000010

1500489
type: Gene
SIO_000068: ncbigene

position:625864:1
position: 625864
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:626205:1
position: 626205
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:625864-626205:1:exon

YKR095W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCC1
locus tag: YKR095W-A
product: chromatin DNA-binding EKC/KEOPS complex subunit PCC1
transcript id: NM_001184522.3
SIO_010081: YKR095W-A
subclass of: SO_0000673
so part of: YKR095W-A
location: join(<625864..625901,625977..>626205)
location: region:625864-626205:1
so has part: feature:625864-625901:1:exon
so has part: feature:625977-626205:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:625864-625901:1:exon

position:625901:1
position: 625901
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:625977-626205:1:exon

position:625977:1
position: 625977
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YKR095W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCC1
locus tag: YKR095W-A
experiment: EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16874308]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]
experiment: EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]
experiment: EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21183954|PMID:21459853]
note: Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3
codon start: 1
product: chromatin DNA-binding EKC/KEOPS complex subunit PCC1
translation: MTSKREKSLDHTLELKIPFETERQATIATKVLSPDPILKPQDFQVDYSSEKNVMLVQFRSIDDRVLRVGVSSIIDSIKTIVEAMDVLS
SIO_010081: YKR095W-A
subclass of: SO_0000673
so part of: YKR095W-A
location: join(625864..625901,625977..626205)
location: region:625864-626205:1
so has part: feature:625864-625901:1:exon
so has part: feature:625977-626205:1:exon

NP_878113.4
type: Protein
SIO_000068: ncbiprotein

S000028512
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:625864-625901:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:625977-626205:1:exon

YKR096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ESL2
locus tag: YKR096W
so part of: sequence
location: <626793..>630380
location: region:626793-630380:1
so has part: feature:626793-630380:1:exon
subclass of: SO_0000010

853971
type: Gene
SIO_000068: ncbigene

position:626793:1
position: 626793
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:630380:1
position: 630380
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:626793-630380:1:exon

YKR096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ESL2
locus tag: YKR096W
product: Esl2p
transcript id: NM_001179886.1
SIO_010081: YKR096W
subclass of: SO_0000673
so part of: YKR096W
location: <626793..>630380
location: region:626793-630380:1
so has part: feature:626793-630380:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:626793-630380:1:exon

YKR096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ESL2
locus tag: YKR096W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22375831]
note: hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication
codon start: 1
product: Esl2p
translation: MPETSVQNPLRLSENENTRSMFLSASQQQRPSATPSFPRLVRNTTANLSLSDFQVLNPSSKRQNSNSVYDDINSSKRRISRPRFSDIEGKNNDHTYPERTTVKESEKNPSPRYVSSSKRALKRENSVGITQSSALISKSFSENGGSIAHEKWSPENMIKPLNVSQNSLAFVDAGSDEQSKSEIVGGFQRKSNNSQEINDKDNSARDQDFNNSGNNNNNNNHSSNNNDNNNNNNDDNNNNNNSNSRDNNNNSDDSNEREENDSCKPASNKRSGIALIQKLQELYKVIVKQEIELQERCSQLTNSQTTELKSLWTIYKINTDLVNNYVTFITTALLPSQPPHDLVIGQEIVEIYRIERRLWVYGTITFLDVLKNFSNFMDPEVCCQFITHVFVSLSTMISDIPSKYSITWLQRLGDLSRMAIALYPSSFIDWKLSAEHWYTEAMKYIYNHGKLYYHMSTVQQNTLEAFVNLGKSVFCQETFTPSPQYMQLVIDNIYQRAFVERNNGNLRNSLLIEYLKHSEAMLLPSFLESPDLQNVVLSYFIEKFGIDANGCNIFNAEDMFVQNPDFFKYFFRHGPSFAQSHILQIVGFGEPKNPFAILFELPKYLKERKDKKERKKSSNNDSSVTESSTGNSRNDNEDDDEIMSSTTSISDHDLLAEFFNDIDTLRRPILPSMLTNEAWLETLKFLNMTSLKCGIIVLRKFLHGPLGIALPHILPWIYFIISICLKSSQLSDPVSKEFWMIIVKRAFPWDTMVTFMNVLIVYLLDNQTSNSIIGDLCDDYDKLSLSELLELFNEGEELPEILGCWGTLWFDTICEKNTHSISSEDNFQEIGIKDYMALDSPTDGIIFDEKDENGEKFWKRACRTIFLFRELSRSFPIGVIIRNDPLIYRSSFQNTNILGSLVFKLEPLCNIHNNIPVLGALESIIDISEARSENNTDLHAVPELSVNEGDNIFHYVGYKKLRADYTCFDKNGEFLSASLYTTWYVPNSNNTNIEDNINYNSEKENEGLFLECIKSDYPEIDFKTTYFVFDATSWLRHSARIFKLAQNRLLRFAICLTTFQELRFLRKSKDENVMEAATRGIITIRQLYYENKVLPLRFTGNVATHIEENLEFEEQITWRTHVDEFVIESVMKAQEKLESASEPRLSPRRFNYVVLISDDDAMKKKAEEKEIKTLSTRFVFSLCTKLGEQRHLCTD
SIO_010081: YKR096W
subclass of: SO_0000673
so part of: YKR096W
location: 626793..630380
location: region:626793-630380:1
so has part: feature:626793-630380:1:exon

NP_013022.1
type: Protein
SIO_000068: ncbiprotein

S000001804
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:626793-630380:1:exon

YKR097W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: JPM2
alternative label: PPC1
gene: PCK1
locus tag: YKR097W
gene synonym: JPM2; PPC1
so part of: sequence
location: <631152..>632801
location: region:631152-632801:1
so has part: feature:631152-632801:1:exon
subclass of: SO_0000010

853972
type: Gene
SIO_000068: ncbigene

position:631152:1
position: 631152
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:632801:1
position: 632801
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:631152-632801:1:exon

YKR097W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: JPM2
alternative label: PPC1
gene: PCK1
locus tag: YKR097W
gene synonym: JPM2; PPC1
product: phosphoenolpyruvate carboxykinase PCK1
transcript id: NM_001179887.3
SIO_010081: YKR097W
subclass of: SO_0000673
so part of: YKR097W
location: <631152..>632801
location: region:631152-632801:1
so has part: feature:631152-632801:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:631152-632801:1:exon

YKR097W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: JPM2
alternative label: PPC1
gene: PCK1
locus tag: YKR097W
gene synonym: JPM2; PPC1
EC number: 4.1.1.49
experiment: EXISTENCE:direct assay:GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity [PMID:16330239]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:196563]
experiment: EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:2689220]
experiment: EXISTENCE:mutant phenotype:GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity [PMID:2689220]
note: Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
codon start: 1
product: phosphoenolpyruvate carboxykinase PCK1
translation: MSPSKMNATVGSTSEVEQKIRQELALSDEVTTIRRNAPAAVLYEDGLKENKTVISSSGALIAYSGVKTGRSPKDKRIVEEPTSKDEIWWGPVNKPCSERTWSINRERAADYLRTRDHIYIVDAFAGWDPKYRIKVRVVCARAYHALFMTNMLIRPTEEELAHFGEPDFTVWNAGQFPANLHTQDMSSKSTIEINFKAMEMIILGTEYAGEMKKGIFTVMFYLMPVHHNVLTLHSSANQGIQNGDVTLFFGLSGTGKTTLSADPHRLLIGDDEHCWSDHGVFNIEGGCYAKCINLSAEKEPEIFDAIKFGSVLENVIYDEKSHVVDYDDSSITENTRCAYPIDYIPSAKIPCLADSHPKNIILLTCDASGVLPPVSKLTPEQVMYHFISGYTSKMAGTEQGVTEPEPTFSSCFGQPFLALHPIRYATMLATKMSQHKANAYLINTGWTGSSYVSGGKRCPLKYTRAILDSIHDGSLANETYETLPIFNLQVPTKVNGVPAELLNPAKNWSQGESKYRGAVTNLANLFVQNFKIYQDRATPDVLAAGPQFE
SIO_010081: YKR097W
subclass of: SO_0000673
so part of: YKR097W
location: 631152..632801
location: region:631152-632801:1
so has part: feature:631152-632801:1:exon

NP_013023.3
type: Protein
SIO_000068: ncbiprotein

S000001805
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:631152-632801:1:exon

YKR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBP11
locus tag: YKR098C
so part of: sequence
location: complement(<633026..>635179)
location: region:633026-635179:-1
so has part: feature:633026-635179:-1:exon
subclass of: SO_0000010

853973
type: Gene
SIO_000068: ncbigene

position:633026:-1
position: 633026
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:635179:-1
position: 635179
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:633026-635179:-1:exon

YKR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBP11
locus tag: YKR098C
product: ubiquitin-specific protease UBP11
transcript id: NM_001179888.1
SIO_010081: YKR098C
subclass of: SO_0000673
so part of: YKR098C
location: complement(<633026..>635179)
location: region:633026-635179:-1
so has part: feature:633026-635179:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:633026-635179:-1:exon

YKR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBP11
locus tag: YKR098C
EC number: 3.4.19.12
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:10527495]
note: Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-specific protease UBP11
translation: MLLNPDQILNLVRKVYEVDIKQFYSQLRLKNLRGLLDHAAHLFNVYLRDLEINQEMEALTAFIIGCYYLYLIIPQSLQFQTRNNLYSSYAKLKNDYQDEHVMGYVLKVVRDESTVIVDRYLAESNGICRTIKRKRAYSLPLRPLPVHMASLSIHNKFDGSLHEIPNELTKPTNDNSKEDIVRESNQIASSNKLEAGSEVAYYTSKEALSKPSYLKLSTGKDALFKTLSSPATAPPVHSLEVSSQIRDSSQDSSSSLSKVEKPKEEEGKIEAIESSAPKAYNLPVIEDSNDLLSELSITGLQNPCNTCYINSIIQCLFGTTLFRDLFLTKKYRLFLNTNKYPKEVQLSRSIYVLFKKMYLNGGRAIIPNRFLKMCKKLRPDLNIPDDQQDTQEFLLIVLARIHEELSNENVVKYYPDLVSYDANALQVNPSKYEKWYERNVITDGLSPIDHIYRGQLENILKCQRCGNSSYSYSTFYVLSLAIPKLSLYSFTSKSRKIKLEDCINLFTGDEELSGDNAWDCPNCRITDSKSKKEEITSQKKKSTIFGFHSRSRSKSPHHHHHHHHSSDDSTKNAKKRNSKKLTTIKSLDFIVLPPILVIHLSRFYYDLTKKNSTVITYPLILNIILKNGKVIRYKLYGTVNHSGNLINGHYTSVVNKEKSHEIGLNRQVWVTFDDDYIQQHRKDRNNFEAGKTEMSSDEVYVLFYERMDEENYEEEFC
SIO_010081: YKR098C
subclass of: SO_0000673
so part of: YKR098C
location: complement(633026..635179)
location: region:633026-635179:-1
so has part: feature:633026-635179:-1:exon

NP_013024.1
type: Protein
SIO_000068: ncbiprotein

S000001806
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:633026-635179:-1:exon

YKR099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BAS1
locus tag: YKR099W
so part of: sequence
location: <635851..>638286
location: region:635851-638286:1
so has part: feature:635851-638286:1:exon
subclass of: SO_0000010

853974
type: Gene
SIO_000068: ncbigene

position:635851:1
position: 635851
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:638286:1
position: 638286
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:635851-638286:1:exon

YKR099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BAS1
locus tag: YKR099W
product: Bas1p
transcript id: NM_001179889.3
SIO_010081: YKR099W
subclass of: SO_0000673
so part of: YKR099W
location: <635851..>638286
location: region:635851-638286:1
so has part: feature:635851-638286:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:635851-638286:1:exon

YKR099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BAS1
locus tag: YKR099W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1495962|PMID:2683089]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1495962]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9705508]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1495962]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3303332]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1495962]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1495962|PMID:3303332]
note: Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; controls cellular ATP levels; also involved in regulation of meiotic recombination at specific genes
codon start: 1
product: Bas1p
translation: MSNISTKDIRKSKPKRGSGFDLLEVTESLGYQTHRKNGRNSWSKDDDNMLRSLVNESAKELGYENGLEDVKTIQQSNHLSKCIAWDVLATRFKHTVRTSKDVRKRWTGSLDPNLKKGKWTQEEDEQLLKAYEEHGPHWLSISMDIPGRTEDQCAKRYIEVLGPGSKGRLREWTLEEDLNLISKVKAYGTKWRKISSEMEFRPSLTCRNRWRKIITMVVRGQASEVITKAIKENKNIDMTDGKLRQHPIADSDIRSDSTPNKEEQLQLSQQNNPSLIKQDILNVKENESSKLPRLKDNDGPILNDSKPQALPPLKEISAPPPIRMTQVGQTHTSGSIRSKVSLPIEGLSQMNKQSPGGISDSPQTSLPPAFNPASLDEHMMNSNSISDSPKHAYSTVKTREPNSSSTQWKFTLKDGQGLSISNGTIDSTKLVKELVDQAKKYSLKISIHQHIHNHYVTSTDHPVSSNTGLSNIGNINGNPLLMDSFPHMGRQLGNGLPGLNSNSDTFNPEYRTSLDNMDSDFLSRTPNYNAFSLEATSHNPADNANELGSQSNRETNSPSVFYPQANTLIPTNSTATNNEIIQGNVSANSMSPNFNGTNGKAPSSTASYTTSGSEMPPDVGPNRIAHFNYLPPTIRPHLGSSDATRGADLNKLLNPSPNSVRSNGSKTKKKEKRKSESSQHHSSSSVTTNKFNHIDQSEISRTTSRSDTPLRDEDGLDFWETLRSLATTNPNPPVEKSAENDGAKPQVVHQGIGSHTEDSSLGSHSGGYDFFNELLDKKADTLHNEAKKTSEHDMTSGGSTDNGSVLPLNPS
SIO_010081: YKR099W
subclass of: SO_0000673
so part of: YKR099W
location: 635851..638286
location: region:635851-638286:1
so has part: feature:635851-638286:1:exon

NP_013025.3
type: Protein
SIO_000068: ncbiprotein

S000001807
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:635851-638286:1:exon

YKR100C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YKR099C-A
gene: SKG1
locus tag: YKR100C
gene synonym: YKR099C-A
so part of: sequence
location: complement(<638901..>639968)
location: region:638901-639968:-1
so has part: feature:638901-639968:-1:exon
subclass of: SO_0000010

853975
type: Gene
SIO_000068: ncbigene

position:638901:-1
position: 638901
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:639968:-1
position: 639968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:638901-639968:-1:exon

YKR100C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YKR099C-A
gene: SKG1
locus tag: YKR100C
gene synonym: YKR099C-A
product: Skg1p
transcript id: NM_001179890.1
SIO_010081: YKR100C
subclass of: SO_0000673
so part of: YKR100C
location: complement(<638901..>639968)
location: region:638901-639968:-1
so has part: feature:638901-639968:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:638901-639968:-1:exon

YKR100C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YKR099C-A
gene: SKG1
locus tag: YKR100C
gene synonym: YKR099C-A
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15645486]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15645486]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15645486]
note: Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication
codon start: 1
product: Skg1p
translation: MTASTSVAVGCAVGIPVGVGIIIAVCFWFNLQKRYKREEQDDRELERAIYDESGFVSFDNFGPLRDSKDEAALASSELKNPDHTSGSSEGSAHPEEKDGKSRDQEKPLGKKNSKYYVPAYRRKINLLQVRNNNYGNNARQKSVVDLPSINNSSNVSLSSSQRHITKRQISVYDQMVPVISDEGPNFFADPSSDTNTSNDQNKASMIELKHNTRQSSNENLIRNLQNQDFGSYYPRRASSSFLNGNISNASFHTRNSSITSVNKRDALEDVFATPKSAAQSQLPNTFDKDNEGMDADHSVKDSRSAITDKDKDLYKLQNNYDVGNIGEIAEEDQYENEFTNYSQSKREFIESLRPK
SIO_010081: YKR100C
subclass of: SO_0000673
so part of: YKR100C
location: complement(638901..639968)
location: region:638901-639968:-1
so has part: feature:638901-639968:-1:exon

NP_013026.2
type: Protein
SIO_000068: ncbiprotein

S000001808
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:638901-639968:-1:exon

YKR101W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SIR1
locus tag: YKR101W
so part of: sequence
location: <640540..>642504
location: region:640540-642504:1
so has part: feature:640540-642504:1:exon
subclass of: SO_0000010

853976
type: Gene
SIO_000068: ncbigene

position:640540:1
position: 640540
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:642504:1
position: 642504
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:640540-642504:1:exon

YKR101W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SIR1
locus tag: YKR101W
product: Sir1p
transcript id: NM_001179891.3
SIO_010081: YKR101W
subclass of: SO_0000673
so part of: YKR101W
location: <640540..>642504
location: region:640540-642504:1
so has part: feature:640540-642504:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:640540-642504:1:exon

YKR101W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SIR1
locus tag: YKR101W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12897051|PMID:12975325|PMID:12198162]
experiment: EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:8622770]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:3297920]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:2684414]
note: Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
codon start: 1
product: Sir1p
translation: MLQINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPNDDDYKKLSQQNLVDWTRLKKDSNSVLVGVKSMELFKHIKLVLREFFLLEDGRIILKRIRSKLRYKVVKKLTCKCCRLYLPKWGTVYIHPMLKDKEKPLAGVCEFSLDVNPDREYPLIEINVSHQYIIIEGFLLYLNERRLYRWNDNNLRSQVGLTKWAHLRKTYNPVSLDILYSLNSNFYFVKDDLLFQLLGKRVFVKFCKVMENGKCGKAPLWYRVKRTTTAKATHIAYAISNSTAPDSFKSKNNDYRFIVREKPIVENTISNLDYSDIKKQQFTEAEVVKRKISADISQIENVHTQFNSQKEKNNIRVNKVSSEVLDQISKFPVSRVTLLLMSAGQDKNYIELVEELARRLEKICIEKTTQSLEEIRDTFQANPEMQASFDKEYYQSIEEYKITLELIKEDLLITLIKQMENMWAAEKKFSTEEEYVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKDHQRAMIDQMNLVKWNDFKKYQDPIPLKAKTLFKFCKQIKKKFLRGADFKLHTLPTEANLKYEPERMTVLCSCVPILLDDQTVQYLYDDSIIPEFEATSSYATKQSKCGRKMSLQMEPDLLFQEAIRRMRHLTAYDVLRRNYIAAFEELYMGNCND
SIO_010081: YKR101W
subclass of: SO_0000673
so part of: YKR101W
location: 640540..642504
location: region:640540-642504:1
so has part: feature:640540-642504:1:exon

NP_013027.4
type: Protein
SIO_000068: ncbiprotein

S000001809
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:640540-642504:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS1123; Autonomously Replicating Sequence
so part of: sequence
location: 642727..642973
location: region:642727-642973:1
so has part: feature:642727-642973:1:region

S000118410
type: SGD
SIO_000068: sgd

position:642727:1
position: 642727
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:642973:1
position: 642973
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:642727-642973:1:region

YKR102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FLO10
locus tag: YKR102W
so part of: sequence
location: <646356..>649865
location: region:646356-649865:1
so has part: feature:646356-649865:1:exon
subclass of: SO_0000010

853977
type: Gene
SIO_000068: ncbigene

position:646356:1
position: 646356
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:649865:1
position: 649865
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:646356-649865:1:exon

YKR102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FLO10
locus tag: YKR102W
product: Flo10p
transcript id: NM_001179892.1
SIO_010081: YKR102W
subclass of: SO_0000673
so part of: YKR102W
location: <646356..>649865
location: region:646356-649865:1
so has part: feature:646356-649865:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:646356-649865:1:exon

YKR102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FLO10
locus tag: YKR102W
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19420680|PMID:11027318|PMID:19087208]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:11027318|PMID:19087208]
experiment: EXISTENCE:mutant phenotype:GO:0044182 filamentous growth of a population of unicellular organisms [PMID:11027318]
note: Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
codon start: 1
product: Flo10p
translation: MPVAARYIFLTGLFLLSVANVALGTTEACLPAGEKKNGMTINFYQYSLKDSSTYSNPSYMAYGYADAEKLGSVSGQTKLSIDYSIPCNGASDTCACSDDDATEYSASQVVPVKRGVKLCSDNTTLSSKTEKRENDDCDQGAAYWSSDLFGFYTTPTNVTVEMTGYFLPPKTGTYTFGFATVDDSAILSVGGNVAFECCKQEQPPITSTDFTINGIKPWNADAPTDIKGSTYMYAGYYYPIKIVYSNAVSWGTLPVSVVLPDGTEVNDDFEGYVFSFDDNATQAHCSVPNPAEHARTCVSSATSSWSSSEVCTECTETESTSYVTPYVTSSSWSSSEVCTECTETESTSTSTPYVTSSSSSSSEVCTECTETESTSYVTPYVSSSTAAANYTSSFSSSSEVCTECTETESTSTSTPYVTSSSWSSSEVCTECTETESTSYVTPYVSSSTAAANYTSSFSSSSEVCTECTETESTSTSTPYVTSSSSSSSEVCTECTETESTSYVTPYVSSSTAAANYTSSFSSSSEVCTECTETESTSTSTPYVTSSSWSSSEVCTECTETESTSYVTPYVSSSTAAANYTSSFSSSSEVCTECTETESTSTSTPYATSSTGTATSFTASTSNTMTSLVQTDTTVSFSLSSTVSEHTNAPTSSVESNASTFISSNKGSVKSYVTSSIHSITPMYPSNQTVTSSSVVSTPITSESSESSASVTILPSTITSEFKPSTMKTKVVSISSSPTNLITSYDTTSKDSTVGSSTSSVSLISSISLPSSYSASSEQIFHSSIVSSNGQALTSFSSTKVSSSESSESHRTSPTTSSESGIKSSGVEIESTSTSSFSFHETSTASTSVQISSQFVTPSSPISTVAPRSTGLNSQTESTNSSKETMSSENSASVMPSSSATSPKTGKVTSDETSSGFSRDRTTVYRMTSETPSTNEQTTLITVSSCESNSCSNTVSSAVVSTATTTINGITTEYTTWCPLSATELTTVSKLESEEKTTLITVTSCESGVCSETASPAIVSTATATVNDVVTVYSTWSPQATNKLAVSSDIENSASKASFVSEAAETKSISRNNNFVPTSGTTSIETHTTTTSNASENSDNVSASEAVSSKSVTNPVLISVSQQPRGTPASSMIGSSTASLEMSSYLGIANHLLTNSGISIFIASLLLAIV
SIO_010081: YKR102W
subclass of: SO_0000673
so part of: YKR102W
location: 646356..649865
location: region:646356-649865:1
so has part: feature:646356-649865:1:exon

NP_013028.1
type: Protein
SIO_000068: ncbiprotein

S000001810
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:646356-649865:1:exon

YKR103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NFT1
locus tag: YKR103W
so part of: sequence
location: <653080..>656736
location: region:653080-656736:1
so has part: feature:653080-656736:1:exon
subclass of: SO_0000010

853978
type: Gene
SIO_000068: ncbigene

position:653080:1
position: 653080
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:656736:1
position: 656736
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:653080-656736:1:exon

YKR103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NFT1
locus tag: YKR103W
product: putative multidrug transporter NFT1
transcript id: NM_001179893.3
SIO_010081: YKR103W
subclass of: SO_0000673
so part of: YKR103W
location: <653080..>656736
location: region:653080-656736:1
so has part: feature:653080-656736:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:653080-656736:1:exon

YKR103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NFT1
locus tag: YKR103W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23658021]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein
codon start: 1
product: putative multidrug transporter NFT1
translation: MIKNGTCPYWERDDLSECARREYIEFKFPLFILLTGMIYAFCKVFRAFYLRGKNHTNEAPEFEEQGNGNHEYARFSVLRLKSAWESRSFCNVNNRSTFDKFKKFIEGAFIVLQLTIHLYILSSMPMDNKKFFHQGFLVQMFLWILLLVVITLRLISASQSFRWVLACKRDLWAVSFYSYASLFTLSILPLRSVFIGKIKDKIMVKYIISETFIDLALLLLLSTSSIEGTRYSFLVENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADIWDLDINNKSIAILANFEMSSKKGRLLPNIICYFKAVFISQLFLAFVSSFLNFVPSLLMPRILSYVNDPKSKSWNLVSLYVSSMLVSKIIATTCRGQGLFLGEKGTMQLRTVLISNIYSKTLRRTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEAMNTFYLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITFSVFIKFQNQTLTPTIAFTALSLFAILRTPMDQIASTVSLLIQSFISLERIQDYLNESETRKYEILEQSNTKFGFEDASMEWEAAETSFKLKNISIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKSNEFLRESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVENFEETKMEGSVKFSAYKWLADYFGGLGVVFVFTSSSILIHGITLSQGFWLRYWLDTGSSGSKSTWLYRIVEGHSNIYFLLTYIIIGLVSSFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADERRFITQSLVAIDRSNAPFFYLNMATEWITYRVDIIGTLVLFSSSVMIIMKAS
SIO_010081: YKR103W
subclass of: SO_0000673
so part of: YKR103W
location: 653080..656736
location: region:653080-656736:1
so has part: feature:653080-656736:1:exon

NP_013029.3
type: Protein
SIO_000068: ncbiprotein

S000001811
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:653080-656736:1:exon

YKR104W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NFT1
locus tag: YKR104W
gene synonym: NFT1
so part of: sequence
location: <656836..>657756
location: region:656836-657756:1
so has part: feature:656836-657756:1:exon
subclass of: SO_0000010

853979
type: Gene
SIO_000068: ncbigene

position:656836:1
position: 656836
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:657756:1
position: 657756
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:656836-657756:1:exon

YKR104W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NFT1
locus tag: YKR104W
gene synonym: NFT1
product: uncharacterized protein
transcript id: NM_001179894.1
SIO_010081: YKR104W
subclass of: SO_0000673
so part of: YKR104W
location: <656836..>657756
location: region:656836-657756:1
so has part: feature:656836-657756:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:656836-657756:1:exon

YKR104W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NFT1
locus tag: YKR104W
gene synonym: NFT1
note: Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein
codon start: 1
product: uncharacterized protein
translation: MSSVERIKEYTDIPSESNGYISPPANWPQTGDVELKNLSLRYSPHSSKALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIFYRLCRQSGEFENLFELAKVSFDNKR
SIO_010081: YKR104W
subclass of: SO_0000673
so part of: YKR104W
location: 656836..657756
location: region:656836-657756:1
so has part: feature:656836-657756:1:exon

NP_013030.1
type: Protein
SIO_000068: ncbiprotein

S000001812
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:656836-657756:1:exon

YKR105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VBA5
locus tag: YKR105C
so part of: sequence
location: complement(<658716..>660464)
location: region:658716-660464:-1
so has part: feature:658716-660464:-1:exon
subclass of: SO_0000010

853980
type: Gene
SIO_000068: ncbigene

position:658716:-1
position: 658716
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:660464:-1
position: 660464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:658716-660464:-1:exon

YKR105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VBA5
locus tag: YKR105C
product: basic amino acid transporter
transcript id: NM_001179895.3
SIO_010081: YKR105C
subclass of: SO_0000673
so part of: YKR105C
location: complement(<658716..>660464)
location: region:658716-660464:-1
so has part: feature:658716-660464:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:658716-660464:-1:exon

YKR105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VBA5
locus tag: YKR105C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23047103]
experiment: EXISTENCE:genetic interaction:GO:1903826 L-arginine transmembrane transport [PMID:23047103]
experiment: EXISTENCE:mutant phenotype:GO:1903826 L-arginine transmembrane transport [PMID:23047103]
note: Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication
codon start: 1
product: basic amino acid transporter
translation: MEETKYSSQQEIEGACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFGNYSKTGWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIFGRVVAGVGGSGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTYKAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNSGQVITYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPLLLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIASGVITKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSNKKLIIPKKDDTPEDNLEDK
SIO_010081: YKR105C
subclass of: SO_0000673
so part of: YKR105C
location: complement(658716..660464)
location: region:658716-660464:-1
so has part: feature:658716-660464:-1:exon

NP_013031.3
type: Protein
SIO_000068: ncbiprotein

S000001813
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:658716-660464:-1:exon

YKR106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GEX2
locus tag: YKR106W
so part of: sequence
location: <661442..>663289
location: region:661442-663289:1
so has part: feature:661442-663289:1:exon
subclass of: SO_0000010

853981
type: Gene
SIO_000068: ncbigene

position:661442:1
position: 661442
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:663289:1
position: 663289
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:661442-663289:1:exon

YKR106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GEX2
locus tag: YKR106W
product: glutathione exchanger
transcript id: NM_001179896.1
SIO_010081: YKR106W
subclass of: SO_0000673
so part of: YKR106W
location: <661442..>663289
location: region:661442-663289:1
so has part: feature:661442-663289:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:661442-663289:1:exon

YKR106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GEX2
locus tag: YKR106W
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:21490148]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21490148]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication
codon start: 1
product: glutathione exchanger
translation: MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYSMTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYSEHSLLSTVQVINAVVSVGSQVVYSRLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLKWRMFYQYASYWPYIIIPWISGNIITAANPQKNWSWNIAMWAFIYPLSTLPIIFLILYMKYKSSKTAEWRSLKEQARKERTGGLFENLVFLFWKLDIVGILLITVSLGCILVPLTLANETSQKWHNSKIIATLVSGGCLFFIFLYWEAKFAKSPLLPFKLLSDRGIWAPLGVTFFNFFTFFISCDYLYPVLLVSMKESSTSAARIVNLPDFVAATASPFYSLLVAKTRKLKLSVIGGCAAWMVCMGLFYKYRGGSGSHEGVIAASVIMGLSGLLCSNSVIVILQAMTTHSRMAVITGIQYTFSKLGAAIGASVSGAIWTQTMPNQLYKNLGNDTLAEIAYASPYTFISDYPWGSPERDAVVESYRYVQRIIMTVGLACTVPFFTFTMFMRNPELIDKATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKSGC
SIO_010081: YKR106W
subclass of: SO_0000673
so part of: YKR106W
location: 661442..663289
location: region:661442-663289:1
so has part: feature:661442-663289:1:exon

NP_013032.1
type: Protein
SIO_000068: ncbiprotein

S000001814
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:661442-663289:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty5 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 665430..665668
location: region:665430-665668:1
so has part: feature:665430-665668:1:region

S000007063
type: SGD
SIO_000068: sgd

position:665430:1
position: 665430
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:665668:1
position: 665668
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:665430-665668:1:region

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL11R; Telomeric region on the right arm of Chromosome XI; composed of an X element core sequence, X element combinatorial repeats, and a terminal stretch of telomeric repeats
so part of: sequence
location: 665904..666816
location: region:665904-666816:1
so has part: feature:665904-666816:1:region

S000028978
type: SGD
SIO_000068: sgd

position:665904:1
position: 665904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:665904-666816:1:region