Saccharomyces cerevisiae S288C chromosome VIII, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome VIII, complete sequence.
sequence version: NC_001140.6
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001140.6
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 8849441
reference: 3
references: 8091229
reference: 4
reference: 5
reference: 6
reference: 7
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006934.\n\nOn Apr 26, 2011 this sequence version replaced NC_001140.5.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 562643
topology: linear
so has quality: SO_0000987
location: 1..562643
location: region:1-562643:1
RO_0002162: 559292

NC_001140
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

3
title: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII
author: Johnston, M.
author: Andrews, S.
author: Brinkman, R.
author: Cooper, J.
author: Ding, H.
author: Dover, J.
author: Du, Z.
author: Favello, A.
author: Fulton, L.
author: Gattung, S. et al.
journal: Science
volume: 265
issue: 5181
pages: 2077-2082
year: 1994
pubmed: 8091229

8091229
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

7
title: Direct Submission
journal: Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:562643:1
position: 562643
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-562643:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: VIII

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL08L; Telomeric region on the left arm of Chromosome VIII; composed of an X element core sequence, an X element combinatorial repeat, a short Y' element, and a short terminal stretch of telomeric repeats
so part of: sequence
location: complement(1..5505)
location: region:1-5505:-1
so has part: feature:1-5505:-1:region

S000028891
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:5505:-1
position: 5505
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-5505:-1:region

YHL050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL050C
so part of: sequence
location: complement(<445..>3311)
location: region:445-3311:-1
so has part: feature:445-3311:-1:exon
subclass of: SO_0000010

856335
type: Gene
SIO_000068: ncbigene

position:445:-1
position: 445
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:3311:-1
position: 3311
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:445-3311:-1:exon

YHL050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL050C
product: uncharacterized protein
transcript id: NM_001179130.1
SIO_010081: YHL050C
subclass of: SO_0000673
so part of: YHL050C
location: complement(join(<445..1897,2671..>3311))
location: region:445-3311:-1
so has part: feature:2671-3311:-1:exon
so has part: feature:445-1897:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:2671-3311:-1:exon

position:2671:-1
position: 2671
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:445-1897:-1:exon

position:1897:-1
position: 1897
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHL050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL050C
note: hypothetical protein; potential Cdc28p substrate
codon start: 1
product: uncharacterized protein
translation: MADTPSVAVQAPPGYGKTELFHLPLIALASKGDVEYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDELHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSKVPLGTNATTTASTNVRTSATTTASINVRTSATTTASINVRTSATTTESTNSNTNATTTESTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKEPYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRREIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCQEEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
SIO_010081: YHL050C
subclass of: SO_0000673
so part of: YHL050C
location: complement(join(445..1897,2671..3311))
location: region:445-3311:-1
so has part: feature:2671-3311:-1:exon
so has part: feature:445-1897:-1:exon

NP_011813.1
type: Protein
SIO_000068: ncbiprotein

S000001042
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:2671-3311:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:445-1897:-1:exon

YHL049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL049C
so part of: sequence
location: complement(<3726..>4541)
location: region:3726-4541:-1
so has part: feature:3726-4541:-1:exon
subclass of: SO_0000010

856336
type: Gene
SIO_000068: ncbigene

position:3726:-1
position: 3726
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:4541:-1
position: 4541
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:3726-4541:-1:exon

YHL049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL049C
product: uncharacterized protein
transcript id: NM_001179129.1
SIO_010081: YHL049C
subclass of: SO_0000673
so part of: YHL049C
location: complement(<3726..>4541)
location: region:3726-4541:-1
so has part: feature:3726-4541:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:3726-4541:-1:exon

YHL049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL049C
codon start: 1
product: uncharacterized protein
translation: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEIASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPHMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDVLHVCCPS
SIO_010081: YHL049C
subclass of: SO_0000673
so part of: YHL049C
location: complement(3726..4541)
location: region:3726-4541:-1
so has part: feature:3726-4541:-1:exon

NP_011814.1
type: Protein
SIO_000068: ncbiprotein

S000001041
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:3726-4541:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS801; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 5471..6401
location: region:5471-6401:1
so has part: feature:5471-6401:1:region

S000130145
type: SGD
SIO_000068: sgd

position:5471:1
position: 5471
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6401:1
position: 6401
reference: sequence
type: ForwardStrandPosition
type: ExactPosition
type: FuzzyPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5471-6401:1:region

YHL048C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL048C-A
so part of: sequence
location: complement(<5663..>5797)
location: region:5663-5797:-1
so has part: feature:5663-5797:-1:exon
subclass of: SO_0000010

1466524
type: Gene
SIO_000068: ncbigene

position:5663:-1
position: 5663
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5797:-1
position: 5797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5663-5797:-1:exon

YHL048C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL048C-A
product: uncharacterized protein
transcript id: NM_001184650.1
SIO_010081: YHL048C-A
subclass of: SO_0000673
so part of: YHL048C-A
location: complement(<5663..>5797)
location: region:5663-5797:-1
so has part: feature:5663-5797:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:5663-5797:-1:exon

YHL048C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL048C-A
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
note: hypothetical protein; identified by expression profiling and mass spectrometry; localizes to the peroxisome in a Pex5p-dependent manner in oleate
codon start: 1
product: uncharacterized protein
translation: MHDIWVITTSPACFEILYKYCKQKGRARMGGLIVKIIRFNHASV
SIO_010081: YHL048C-A
subclass of: SO_0000673
so part of: YHL048C-A
location: complement(5663..5797)
location: region:5663-5797:-1
so has part: feature:5663-5797:-1:exon

NP_878084.1
type: Protein
SIO_000068: ncbiprotein

S000028829
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:5663-5797:-1:exon

YHL048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS8
locus tag: YHL048W
so part of: sequence
location: <6401..>7546
location: region:6401-7546:1
so has part: feature:6401-7546:1:exon
subclass of: SO_0000010

856337
type: Gene
SIO_000068: ncbigene

position:7546:1
position: 7546
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6401-7546:1:exon

YHL048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS8
locus tag: YHL048W
product: Cos8p
transcript id: NM_001179128.1
SIO_010081: YHL048W
subclass of: SO_0000673
so part of: YHL048W
location: <6401..>7546
location: region:6401-7546:1
so has part: feature:6401-7546:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6401-7546:1:exon

YHL048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS8
locus tag: YHL048W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12051917]
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
codon start: 1
product: Cos8p
translation: MKENEVKDEKSVDVLSFKQLEFQKTVLPQDVFRNELTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSSNWIHPLIVSLLVLFLGPFFVLVICGLSRKRSLSKQLIQFCKEITEDTPSSDPHDWEVVAANLNSYFYENKTWNTKYFFFNAMSCQKAFKTTLLEPFSLKKDESAKVKSFKDSVPYIEEALQVYAAGFDKEWKLFNTEKEESPFDLEDIQLPKEAYRFKLTWILKRIFNLRCLPLFLYYFLIVYTSGNADLISRFLFPVVMFFIMTRDFQNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWNNEEFFYDGLDCEWFFRRFFYRLLSLKKPMWFASLNVELWPYIKEAQSARNEKPLK
SIO_010081: YHL048W
subclass of: SO_0000673
so part of: YHL048W
location: 6401..7546
location: region:6401-7546:1
so has part: feature:6401-7546:1:exon

NP_011815.1
type: Protein
SIO_000068: ncbiprotein

S000001040
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6401-7546:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS802; Autonomously Replicating Sequence
so part of: sequence
location: 7702..7767
location: region:7702-7767:1
so has part: feature:7702-7767:1:region

S000118356
type: SGD
SIO_000068: sgd

position:7702:1
position: 7702
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:7767:1
position: 7767
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7702-7767:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty5 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(7994..8225)
location: region:7994-8225:-1
so has part: feature:7994-8225:-1:region

S000006986
type: SGD
SIO_000068: sgd

position:7994:-1
position: 7994
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:8225:-1
position: 8225
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7994-8225:-1:region

YHL047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAF1
gene: ARN2
locus tag: YHL047C
gene synonym: TAF1
so part of: sequence
location: complement(<8351..>10213)
location: region:8351-10213:-1
so has part: feature:8351-10213:-1:exon
subclass of: SO_0000010

856338
type: Gene
SIO_000068: ncbigene

position:8351:-1
position: 8351
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:10213:-1
position: 10213
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:8351-10213:-1:exon

YHL047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAF1
gene: ARN2
locus tag: YHL047C
gene synonym: TAF1
product: siderophore transporter
transcript id: NM_001179127.2
SIO_010081: YHL047C
subclass of: SO_0000673
so part of: YHL047C
location: complement(<8351..>10213)
location: region:8351-10213:-1
so has part: feature:8351-10213:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:8351-10213:-1:exon

YHL047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAF1
gene: ARN2
locus tag: YHL047C
gene synonym: TAF1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10816729]
experiment: EXISTENCE:direct assay:GO:0015891 siderophore transport [PMID:10816729]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:10816729]
experiment: EXISTENCE:mutant phenotype:GO:0009237 siderophore metabolic process [PMID:10816729]
experiment: EXISTENCE:mutant phenotype:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10748025|PMID:10816729]
experiment: EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:10816729]
note: Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
codon start: 1
product: siderophore transporter
translation: MIEVPEDNRSSQTKRKNTEKNCNELMVDEKMDDDSSPRDEMKDKLKGTKSLIIRKSELMAKKYDTWQLKAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIAMWAFIFPLCCIPLILCMLHMRWKVRNDVEWKELQDEKSYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGGVSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDADLATAAYGSPLTFILSNPWGTPVRSAMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRDPRLTEDFAQKLPDREYVQTKEDDPINDWIAKRFAKALGRS
SIO_010081: YHL047C
subclass of: SO_0000673
so part of: YHL047C
location: complement(8351..10213)
location: region:8351-10213:-1
so has part: feature:8351-10213:-1:exon

NP_011816.2
type: Protein
SIO_000068: ncbiprotein

S000001039
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:8351-10213:-1:exon

YHL046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU13
locus tag: YHL046C
so part of: sequence
location: complement(<11923..>12285)
location: region:11923-12285:-1
so has part: feature:11923-12285:-1:exon
subclass of: SO_0000010

856339
type: Gene
SIO_000068: ncbigene

position:11923:-1
position: 11923
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:12285:-1
position: 12285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11923-12285:-1:exon

YHL046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU13
locus tag: YHL046C
product: seripauperin PAU13
transcript id: NM_001179126.1
SIO_010081: YHL046C
subclass of: SO_0000673
so part of: YHL046C
location: complement(<11923..>12285)
location: region:11923-12285:-1
so has part: feature:11923-12285:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11923-12285:-1:exon

YHL046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU13
locus tag: YHL046C
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively
codon start: 1
product: seripauperin PAU13
translation: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTITN
SIO_010081: YHL046C
subclass of: SO_0000673
so part of: YHL046C
location: complement(11923..12285)
location: region:11923-12285:-1
so has part: feature:11923-12285:-1:exon

NP_011817.1
type: Protein
SIO_000068: ncbiprotein

S000001038
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11923-12285:-1:exon

YHL045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PXP3
locus tag: YHL045W
so part of: sequence
location: <12502..>12849
location: region:12502-12849:1
so has part: feature:12502-12849:1:exon
subclass of: SO_0000010

856340
type: Gene
SIO_000068: ncbigene

position:12502:1
position: 12502
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:12849:1
position: 12849
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:12502-12849:1:exon

YHL045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PXP3
locus tag: YHL045W
product: Pxp3p
transcript id: NM_001416099.1
SIO_010081: YHL045W
subclass of: SO_0000673
so part of: YHL045W
location: <12502..>12849
location: region:12502-12849:1
so has part: feature:12502-12849:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:12502-12849:1:exon

YHL045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PXP3
locus tag: YHL045W
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
note: Peroxisomal hypothetical protein; last 10 C-terminal amino acids contains a novel PTS1 motif, both necessary and sufficient for Pex5p-dependent peroxisomal targeting; also localizes to the nucleus; PXP3 is not an essential gene
codon start: 1
product: Pxp3p
translation: MKMLLFLNEACIFIDSVCEGIVFWGLCLFVCAECGNAYYRGARVPYKTLFRAFEVSVFGQKEYPNFRFGPSYRFLCLSPYSICCKQPPMEEVILYYPSPDSLIKNRKRVLGVAYL
SIO_010081: YHL045W
subclass of: SO_0000673
so part of: YHL045W
location: 12502..12849
location: region:12502-12849:1
so has part: feature:12502-12849:1:exon

NP_001403028.1
type: Protein
SIO_000068: ncbiprotein

S000001037
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:12502-12849:1:exon

YHL044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL044W
so part of: sequence
location: <13565..>14272
location: region:13565-14272:1
so has part: feature:13565-14272:1:exon
subclass of: SO_0000010

856341
type: Gene
SIO_000068: ncbigene

position:13565:1
position: 13565
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14272:1
position: 14272
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:13565-14272:1:exon

YHL044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL044W
product: DUP240 family protein
transcript id: NM_001179124.1
SIO_010081: YHL044W
subclass of: SO_0000673
so part of: YHL044W
location: <13565..>14272
location: region:13565-14272:1
so has part: feature:13565-14272:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:13565-14272:1:exon

YHL044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL044W
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]
note: Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
codon start: 1
product: DUP240 family protein
translation: MSSELLISNSKPRPEGLRKLCEGETVILPRDITPSKCAYFLKQNIVFISYIFIHIIITIILNRLALSAHGNTLIIILAALLITISLFLLLLLPYLSCSRYKLRCLDDDCKFKLLAEVITHKPNMDLSTWDRIAYDMNQFVYDRRICADRSFFYDGSYCYQVFKKLVATPYLVNSNMNSIYADLEMRSNGATNINDSGNSSLHIELGTYIFKALAVFRNSVDKYWEDKYPEMGVTV
SIO_010081: YHL044W
subclass of: SO_0000673
so part of: YHL044W
location: 13565..14272
location: region:13565-14272:1
so has part: feature:13565-14272:1:exon

NP_011819.1
type: Protein
SIO_000068: ncbiprotein

S000001036
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:13565-14272:1:exon

YHL043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM34
locus tag: YHL043W
so part of: sequence
location: <14901..>15413
location: region:14901-15413:1
so has part: feature:14901-15413:1:exon
subclass of: SO_0000010

856342
type: Gene
SIO_000068: ncbigene

position:14901:1
position: 14901
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:15413:1
position: 15413
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:14901-15413:1:exon

YHL043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM34
locus tag: YHL043W
product: Ecm34p
transcript id: NM_001179123.1
SIO_010081: YHL043W
subclass of: SO_0000673
so part of: YHL043W
location: <14901..>15413
location: region:14901-15413:1
so has part: feature:14901-15413:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:14901-15413:1:exon

YHL043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM34
locus tag: YHL043W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol
codon start: 1
product: Ecm34p
translation: MEGRKSEDEKNEAALACDVFESSNAKLPKNVFRSSFTWYCYEVINRSAFHIWLLLCLTLIVGWKVFSGIGGRRPSDSNMDGPQTKHKRNPGFLRRHSTIVILVISLAVSFSWEAFKMYRERTFGKQITQFAKEIIKSAPSTDMESWDRVAADFNSYMYENKLWNTEYFFC
SIO_010081: YHL043W
subclass of: SO_0000673
so part of: YHL043W
location: 14901..15413
location: region:14901-15413:1
so has part: feature:14901-15413:1:exon

NP_011820.1
type: Protein
SIO_000068: ncbiprotein

S000001035
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:14901-15413:1:exon

YHL042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL042W
so part of: sequence
location: <15667..>16119
location: region:15667-16119:1
so has part: feature:15667-16119:1:exon
subclass of: SO_0000010

856343
type: Gene
SIO_000068: ncbigene

position:15667:1
position: 15667
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:16119:1
position: 16119
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:15667-16119:1:exon

YHL042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL042W
product: uncharacterized protein
transcript id: NM_001179122.1
SIO_010081: YHL042W
subclass of: SO_0000673
so part of: YHL042W
location: <15667..>16119
location: region:15667-16119:1
so has part: feature:15667-16119:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:15667-16119:1:exon

YHL042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL042W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31945465]
note: Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER
codon start: 1
product: uncharacterized protein
translation: MKQRFSQVATVIFFVMSIRSPRNLGFFFTLALFVVLVCSQEWFSFEMNRSCSMKVEHRMQFLSTIISEHQKSDVNCWDQIAKKMNVYLFEQKVSGSDVFFLDGADCERFFERNFLRYLPSRKSSHPDLPIAELLPYIRKADIACAGKQLI
SIO_010081: YHL042W
subclass of: SO_0000673
so part of: YHL042W
location: 15667..16119
location: region:15667-16119:1
so has part: feature:15667-16119:1:exon

NP_011821.1
type: Protein
SIO_000068: ncbiprotein

S000001034
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:15667-16119:1:exon

YHL041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL041W
so part of: sequence
location: <17392..>17841
location: region:17392-17841:1
so has part: feature:17392-17841:1:exon
subclass of: SO_0000010

856344
type: Gene
SIO_000068: ncbigene

position:17392:1
position: 17392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17841:1
position: 17841
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:17392-17841:1:exon

YHL041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL041W
product: uncharacterized protein
transcript id: NM_001348807.1
SIO_010081: YHL041W
subclass of: SO_0000673
so part of: YHL041W
location: <17392..>17841
location: region:17392-17841:1
so has part: feature:17392-17841:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:17392-17841:1:exon

YHL041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL041W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MHLYSIAKSTTILRFLRHILLPFLHLSIHFTSCLCRIIYVGWKSFWKHFFFCGHKIKTPLFIASYAMFLAKQKIIVTMFEVSSVLEKLPQNILLFHYPLPSKMGNNLLMSFLTQRSIDEKEIDALLHPNAVYRFCNMRTTFRTLSSYGK
SIO_010081: YHL041W
subclass of: SO_0000673
so part of: YHL041W
location: 17392..17841
location: region:17392-17841:1
so has part: feature:17392-17841:1:exon

NP_001335736.1
type: Protein
SIO_000068: ncbiprotein

S000001033
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:17392-17841:1:exon

YHL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARN1
locus tag: YHL040C
so part of: sequence
location: complement(<19088..>20971)
location: region:19088-20971:-1
so has part: feature:19088-20971:-1:exon
subclass of: SO_0000010

856345
type: Gene
SIO_000068: ncbigene

position:19088:-1
position: 19088
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:20971:-1
position: 20971
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:19088-20971:-1:exon

YHL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARN1
locus tag: YHL040C
product: siderophore transporter
transcript id: NM_001179120.1
SIO_010081: YHL040C
subclass of: SO_0000673
so part of: YHL040C
location: complement(<19088..>20971)
location: region:19088-20971:-1
so has part: feature:19088-20971:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:19088-20971:-1:exon

YHL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARN1
locus tag: YHL040C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:17344478]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15719020]
experiment: EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:10748025]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10802175]
experiment: EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:10802175]
note: ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
codon start: 1
product: siderophore transporter
translation: MESVHSRDPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNALRQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVILYVVGTIIQSQAYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWRLLYQFVPTWPFIINTWIAGNITSRANPVVNWSWDVGMWAFIFPLSCVPIVLCMLHMQWRARKTPEWHALKGQKSYYQEHGFIKILKQLFWMLDVVGVLLMGCSLGCILVPLTLAGGVKTTWNDSRLIGPFVLGFVLIPILWIWEYRFARDPILPYRLVKDRAVWSSMGISFLIDFIYYMAADYLYTVMIVAVNESVKSATRIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRGGSQSHSGIIGALCVWGVGTTLFTYPVTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIWTQTLYKQILKRMGDVALATTAYESPYTFIETYTWGTPQRNALMNAYKYVQRLETIVALVFCVPLIAFSLCLRDPKLTDTVAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTFKRE
SIO_010081: YHL040C
subclass of: SO_0000673
so part of: YHL040C
location: complement(19088..20971)
location: region:19088-20971:-1
so has part: feature:19088-20971:-1:exon

NP_011823.1
type: Protein
SIO_000068: ncbiprotein

S000001032
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:19088-20971:-1:exon

YHL039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EFM1
locus tag: YHL039W
so part of: sequence
location: <21783..>23540
location: region:21783-23540:1
so has part: feature:21783-23540:1:exon
subclass of: SO_0000010

856346
type: Gene
SIO_000068: ncbigene

position:21783:1
position: 21783
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:23540:1
position: 23540
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:21783-23540:1:exon

YHL039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EFM1
locus tag: YHL039W
product: protein-lysine N-methyltransferase
transcript id: NM_001179119.1
SIO_010081: YHL039W
subclass of: SO_0000673
so part of: YHL039W
location: <21783..>23540
location: region:21783-23540:1
so has part: feature:21783-23540:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:21783-23540:1:exon

YHL039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EFM1
locus tag: YHL039W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:22522802]
experiment: EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:20510667|PMID:22522802|PMID:24517342]
note: Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: protein-lysine N-methyltransferase
translation: MITQTELDNCLQWAQNNGAFIDPKISFRITEDAGVSAFVNEKFSPKPDQALIRVPETLLITSQQALSEFSQAANERSLLNSVTQLYLSKLKFGTDAVHLKSFYKPYLDVLPLHLPQPYFWSTDEVMNLHGTDVYLTMRDTLNKLVKEWRMLFQALSIEHSSQDKQFLSLFQENKDSAVVPLEQFCAHINGCKLEDSEWNSFVAYLWSYCIFNSRAFPRVILGRAGTDRTNLNEGFLYPIVDLLNHKNDVPVRWEMNEQNELCFMSQTTTFSAQDELFNNYGNISNEKCLLNYGFWDSSNKFDFSRLTLKLPSTLVSGLPVDFNKSGNFVTDDGETTILQFSLKISEPLPPVLLALFAYLSKLKSEETPTVRSVLEGIDQLTSVVSQRLLFYKNFKIKTSSTQKLRPHVIKLIKLYYQDNKKILNATTEKLSVLQKKIYSNNKEFSLSFKTIFKNDKIFANSLLLVFGAINYEDLITKDCLNDALLLWIVKLINDKSNNQGGFIKQTFKEVSDSIVIEKEDVMEFLPFYKKYFPNLSERIPEIYSVGDWGIRQFIVADTAIDRLVWIRKSNKEPIFLMKKAYDLQI
SIO_010081: YHL039W
subclass of: SO_0000673
so part of: YHL039W
location: 21783..23540
location: region:21783-23540:1
so has part: feature:21783-23540:1:exon

NP_011824.1
type: Protein
SIO_000068: ncbiprotein

S000001031
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:21783-23540:1:exon

YHL038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CBP2
locus tag: YHL038C
so part of: sequence
location: complement(<23617..>25509)
location: region:23617-25509:-1
so has part: feature:23617-25509:-1:exon
subclass of: SO_0000010

856347
type: Gene
SIO_000068: ncbigene

position:23617:-1
position: 23617
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25509:-1
position: 25509
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:23617-25509:-1:exon

YHL038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CBP2
locus tag: YHL038C
product: Cbp2p
transcript id: NM_001179118.1
SIO_010081: YHL038C
subclass of: SO_0000673
so part of: YHL038C
location: complement(<23617..>25509)
location: region:23617-25509:-1
so has part: feature:23617-25509:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:23617-25509:-1:exon

YHL038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CBP2
locus tag: YHL038C
experiment: EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:9092668]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10521416]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2685564|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:10521416]
experiment: EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:6348045]
note: Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
codon start: 1
product: Cbp2p
translation: MVNWQTLFMVSLRRQGSSSRYRYKFNMENITHQVFPRCKQAFKKTNLSYEYCDLEGVLYNISLTDLQKLLLRDINAPREHAFKIVRTDLTQKSSKKRIQHWERIAPMFDHPLSLYEKLFSEMDEDFKPSFEWQQLIRVRCKDDKLKLQRVIWPKSIFSNFCRGIGVKKSTYDRLLEQNNGEVPMFVNPANAKPLPLFQVSDEAMIGEFDGIGIFPYFVDKHREFFVTEVDKLKTKIASPLCTLNERKRIEKANAGRILANEEGKPFYLDANSATTRIAGGNVVTLKQLLERSVSHKTLWSKQSNKDRTCPGDILRATILSNDFSIRQLRAEFCKNFILYNIFTILQRNKKSIRSFSGNDNAPSFQFSWNVWDSYIWKQYQETESMKIPTDQASLINYKTKYDSFLHDLQTYSALVISEMKWNQFSIFQNDETTLSRFEHITLILQTVLTKSKMIRIFQPNLYKFMQDDLRPTLMELVGFTESINATIEPGFANEQSLQSANGLKKLANQLLYFEQEIYGEKFRVNRPIQLRPITLSANYKIVILDKKNAIPEIFQTLLKFMTQITTYFVKDLSEVELHGHMHCIDKKMLDKSKFMYLYEEKSNEEVKAASPQKEKIVDNIIGLLSNDEEH
SIO_010081: YHL038C
subclass of: SO_0000673
so part of: YHL038C
location: complement(23617..25509)
location: region:23617-25509:-1
so has part: feature:23617-25509:-1:exon

NP_011825.1
type: Protein
SIO_000068: ncbiprotein

S000001030
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:23617-25509:-1:exon

YHL037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL037C
so part of: sequence
location: complement(<25778..>26179)
location: region:25778-26179:-1
so has part: feature:25778-26179:-1:exon
subclass of: SO_0000010

856348
type: Gene
SIO_000068: ncbigene

position:25778:-1
position: 25778
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26179:-1
position: 26179
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25778-26179:-1:exon

YHL037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL037C
product: uncharacterized protein
transcript id: NM_001348812.1
SIO_010081: YHL037C
subclass of: SO_0000673
so part of: YHL037C
location: complement(<25778..>26179)
location: region:25778-26179:-1
so has part: feature:25778-26179:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25778-26179:-1:exon

YHL037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL037C
note: hypothetical protein; conserved among S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MYRSSISIQVFICVLFLPLDSGRPLIYMIDLSYICSDATVFSGKSRVIFFSNPICEHTRGNFYLFYLNYIINTFAPKNRGTRRCKPFGLHINCRKKIDCLHVQLSYILCKNKSRKRHMDAHAITLAWLAHALT
SIO_010081: YHL037C
subclass of: SO_0000673
so part of: YHL037C
location: complement(25778..26179)
location: region:25778-26179:-1
so has part: feature:25778-26179:-1:exon

NP_001335737.1
type: Protein
SIO_000068: ncbiprotein

S000001029
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25778-26179:-1:exon

YHL036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MUP3
locus tag: YHL036W
so part of: sequence
location: <26241..>27881
location: region:26241-27881:1
so has part: feature:26241-27881:1:exon
subclass of: SO_0000010

856349
type: Gene
SIO_000068: ncbigene

position:26241:1
position: 26241
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27881:1
position: 27881
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26241-27881:1:exon

YHL036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MUP3
locus tag: YHL036W
product: Mup3p
transcript id: NM_001179116.1
SIO_010081: YHL036W
subclass of: SO_0000673
so part of: YHL036W
location: <26241..>27881
location: region:26241-27881:1
so has part: feature:26241-27881:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26241-27881:1:exon

YHL036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MUP3
locus tag: YHL036W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0015191 L-methionine transmembrane transporter activity [PMID:8893857]
experiment: EXISTENCE:genetic interaction:GO:1903692 methionine import across plasma membrane [PMID:8893857]
experiment: EXISTENCE:mutant phenotype:GO:0015191 L-methionine transmembrane transporter activity [PMID:8893857]
experiment: EXISTENCE:mutant phenotype:GO:1903692 methionine import across plasma membrane [PMID:8893857]
note: Low affinity methionine permease; similar to Mup1p
codon start: 1
product: Mup3p
translation: MEPLLFNSGKANPSQDVFIDVEVGDITTKYGSTNTGSFSSMDTVEAQAIKAETARFMEVPQGRHLGVFSTVVLFVSRIMGSGIFAVPSVILLNTGGNKLIYFAIWVFSAAIAFAGLYLFLEFGSWIPKSGGRKNFLERSFERPRLLISVVFSCYSVLTGYALTGSIVFGKYVLSAFGVTDDSWSKYVSISFIIFAVLIHGVSVRHGVFIQNALGGLKLIMIVLMCFAGLYTLFFYKSTGQVAWDLPVTQVEKDSLLSVSSIATAFISSFFCFSGWDTVHTVTSEIKNPVKTLKVSGPLSLIICFVCYTMMNVAYLKVLTYEEIVSAGPLVGSVLFTKLFGPRVGGKFIAFSIAISAASNILVVIYSISRVNQEIFKEGYLPFSIHMSKNWPFDAPLPSISLCGFITIAWILILPKEGESFNYLVSMDGYGNQFFLLLVAIGLFIWRFKHKNEVPEIRASTFGVLAIITLSLYMLMAPFFADPSLNRVGFLPPYQIMSLLVIVACFFFWLVKFVLLPKFFHYKLLPKITYLHDGLIVTEWVKKPCLC
SIO_010081: YHL036W
subclass of: SO_0000673
so part of: YHL036W
location: 26241..27881
location: region:26241-27881:1
so has part: feature:26241-27881:1:exon

NP_011827.1
type: Protein
SIO_000068: ncbiprotein

S000001028
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26241-27881:1:exon

YHL035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VMR1
locus tag: YHL035C
so part of: sequence
location: complement(<27978..>32756)
location: region:27978-32756:-1
so has part: feature:27978-32756:-1:exon
subclass of: SO_0000010

856350
type: Gene
SIO_000068: ncbigene

position:27978:-1
position: 27978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:32756:-1
position: 32756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27978-32756:-1:exon

YHL035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VMR1
locus tag: YHL035C
product: putative ATP-binding cassette multidrug transporter VMR1
transcript id: NM_001179115.1
SIO_010081: YHL035C
subclass of: SO_0000673
so part of: YHL035C
location: complement(<27978..>32756)
location: region:27978-32756:-1
so has part: feature:27978-32756:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:27978-32756:-1:exon

YHL035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VMR1
locus tag: YHL035C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20846144|PMID:23658021]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:20846144]
experiment: EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:20846144]
experiment: EXISTENCE:mutant phenotype:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:20846144]
note: Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication
codon start: 1
product: putative ATP-binding cassette multidrug transporter VMR1
translation: MGTDPLIIRNNGSFWEVDDFTRLGRTQLLSYYLPLAIIASIGIFALCRSGLSRYVRSAECDLVNEYLFGAQEERKEDNSIERLLRNSNTQANYVNVKKQGRILKLRHFDITTIDVKQIDAKNHGGLTFSRPSTSDHLRKSSEIVLMSLQIIGLSFLRVTKINIELTNRDVTTLLLFWLILLSLSILRVYKRSTNLWAICFTAHTTIWISTWIPIRSVYIGNIDDVPSQIFYIFEFVITSTLQPIKLTSPIKDNSSIIYVRDDHTSPSREHISSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMEDYSIFILKGFTRRNKHINNLTLALFESFKTYLLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSSCMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLVWSVTSFLWFVTPTLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLDQLSNMLSFINQSKVSLKRISDFLRMDDTEKYNQLTISPDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPLMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTITELQSKGLFKEKYVQLSSRDSINEKNANRLKAPRKNDSQKIEPVTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLKFFGGFKALTALFALYITAQILFISQSWWIRHWVNDTNVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSMCRDSGGLELLKQIAKQSSKMMK
SIO_010081: YHL035C
subclass of: SO_0000673
so part of: YHL035C
location: complement(27978..32756)
location: region:27978-32756:-1
so has part: feature:27978-32756:-1:exon

NP_011828.1
type: Protein
SIO_000068: ncbiprotein

S000001027
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:27978-32756:-1:exon

YHL034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSB1
alternative label: SSBR1
gene: SBP1
locus tag: YHL034C
gene synonym: SSB1; SSBR1
so part of: sequence
location: complement(<33193..>34077)
location: region:33193-34077:-1
so has part: feature:33193-34077:-1:exon
subclass of: SO_0000010

856351
type: Gene
SIO_000068: ncbigene

position:33193:-1
position: 33193
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:34077:-1
position: 34077
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:33193-34077:-1:exon

YHL034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSB1
alternative label: SSBR1
gene: SBP1
locus tag: YHL034C
gene synonym: SSB1; SSBR1
product: Sbp1p
transcript id: NM_001179114.1
SIO_010081: YHL034C
subclass of: SO_0000673
so part of: YHL034C
location: complement(<33193..>34077)
location: region:33193-34077:-1
so has part: feature:33193-34077:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:33193-34077:-1:exon

YHL034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSB1
alternative label: SSBR1
gene: SBP1
locus tag: YHL034C
gene synonym: SSB1; SSBR1
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:16782896|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:2121740|PMID:2823109]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16782896]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:22284680]
experiment: EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:22284680]
experiment: EXISTENCE:mutant phenotype:GO:0032055 negative regulation of translation in response to stress [PMID:16782896]
note: Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication
codon start: 1
product: Sbp1p
translation: MSAEIEEATNAVNNLSINDSEQQPRAPTHKTVIDPEDTIFIGNVAHECTEDDLKQLFVEEFGDEVSVEIPIKEHTDGHIPASKHALVKFPTKIDFDNIKENYDTKVVKDREIHIKRARTPGQMQRGGFRGRGGFRGRGGFRGGFRGGYRGGFRGRGNFRGRGGARGGFNGQKREKIPLDQMERSKDTLYINNVPFKATKEEVAEFFGTDADSISLPMRKMRDQHTGRIFTSDSANRGMAFVTFSGENVDIEAKAEEFKGKVFGDRELTVDVAVIRPENDEEEIEQETGSEEKQE
SIO_010081: YHL034C
subclass of: SO_0000673
so part of: YHL034C
location: complement(33193..34077)
location: region:33193-34077:-1
so has part: feature:33193-34077:-1:exon

NP_011829.1
type: Protein
SIO_000068: ncbiprotein

S000001026
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:33193-34077:-1:exon

YHL033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAK7
gene: RPL8A
locus tag: YHL033C
gene synonym: MAK7
so part of: sequence
location: complement(<35255..>36025)
location: region:35255-36025:-1
so has part: feature:35255-36025:-1:exon
subclass of: SO_0000010

856352
type: Gene
SIO_000068: ncbigene

position:35255:-1
position: 35255
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36025:-1
position: 36025
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35255-36025:-1:exon

YHL033C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAK7
gene: RPL8A
locus tag: YHL033C
gene synonym: MAK7
product: ribosomal 60S subunit protein L8A
transcript id: NM_001179113.1
SIO_010081: YHL033C
subclass of: SO_0000673
so part of: YHL033C
location: complement(<35255..>36025)
location: region:35255-36025:-1
so has part: feature:35255-36025:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:35255-36025:-1:exon

YHL033C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAK7
gene: RPL8A
locus tag: YHL033C
gene synonym: MAK7
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]
note: Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog
codon start: 1
product: ribosomal 60S subunit protein L8A
translation: MAPGKKVAPAPFGAKSTKSNKTRNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGKSKQDASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIVKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKNSDSA
SIO_010081: YHL033C
subclass of: SO_0000673
so part of: YHL033C
location: complement(35255..36025)
location: region:35255-36025:-1
so has part: feature:35255-36025:-1:exon

NP_011830.1
type: Protein
SIO_000068: ncbiprotein

S000001025
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:35255-36025:-1:exon

YHL032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GUT1
locus tag: YHL032C
so part of: sequence
location: complement(<36379..>38508)
location: region:36379-38508:-1
so has part: feature:36379-38508:-1:exon
subclass of: SO_0000010

856353
type: Gene
SIO_000068: ncbigene

position:36379:-1
position: 36379
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38508:-1
position: 38508
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36379-38508:-1:exon

YHL032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GUT1
locus tag: YHL032C
product: glycerol kinase
transcript id: NM_001179112.1
SIO_010081: YHL032C
subclass of: SO_0000673
so part of: YHL032C
location: complement(<36379..>38508)
location: region:36379-38508:-1
so has part: feature:36379-38508:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:36379-38508:-1:exon

YHL032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GUT1
locus tag: YHL032C
EC number: 2.7.1.30
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397]
experiment: EXISTENCE:mutant phenotype:GO:0004370 glycerol kinase activity [PMID:8358828]
experiment: EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:8358828]
note: Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
codon start: 1
product: glycerol kinase
translation: MFPSLFRLVVFSKRYIFRSSQRLYTSLKQEQSRMSKIMEDLRSDYVPLIASIDVGTTSSRCILFNRWGQDVSKHQIEYSTSASKGKIGVSGLRRPSTAPARETPNAGDIKTSGKPIFSAEGYAIQETKFLKIEELDLDFHNEPTLKFPKPGWVECHPQKLLVNVVQCLASSLLSLQTINSERVANGLPPYKVICMGIANMRETTILWSRRTGKPIVNYGIVWNDTRTIKIVRDKWQNTSVDRQLQLRQKTGLPLLSTYFSCSKLRWFLDNEPLCTKAYEENDLMFGTVDTWLIYQLTKQKAFVSDVTNASRTGFMNLSTLKYDNELLEFWGIDKNLIHMPEIVSSSQYYGDFGIPDWIMEKLHDSPKTVLRDLVKRNLPIQGCLGDQSASMVGQLAYKPGAAKCTYGTGCFLLYNTGTKKLISQHGALTTLAFWFPHLQEYGGQKPELSKPHFALEGSVAVAGAVVQWLRDNLRLIDKSEDVGPIASTVPDSGGVVFVPAFSGLFAPYWDPDARATIMGMSQFTTASHIARAAVEGVCFQARAILKAMSSDAFGEGSKDRDFLEEISDVTYEKSPLSVLAVDGGMSRSNEVMQIQADILGPCVKVRRSPTAECTALGAAIAANMAFKDVNERPLWKDLHDVKKWVFYNGMEKNEQISPEAHPNLKIFRSESDDAERRKHWKYWEVAVERSKGWLKDIEGEHEQVLENFQ
SIO_010081: YHL032C
subclass of: SO_0000673
so part of: YHL032C
location: complement(36379..38508)
location: region:36379-38508:-1
so has part: feature:36379-38508:-1:exon

NP_011831.1
type: Protein
SIO_000068: ncbiprotein

S000001024
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36379-38508:-1:exon

YHL031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GOS1
locus tag: YHL031C
so part of: sequence
location: complement(<38815..>39486)
location: region:38815-39486:-1
so has part: feature:38815-39486:-1:exon
subclass of: SO_0000010

856354
type: Gene
SIO_000068: ncbigene

position:38815:-1
position: 38815
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:39486:-1
position: 39486
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:38815-39486:-1:exon

YHL031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GOS1
locus tag: YHL031C
product: Gos1p
transcript id: NM_001179111.1
SIO_010081: YHL031C
subclass of: SO_0000673
so part of: YHL031C
location: complement(<38815..>39486)
location: region:38815-39486:-1
so has part: feature:38815-39486:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:38815-39486:-1:exon

YHL031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GOS1
locus tag: YHL031C
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:16699523]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]
experiment: EXISTENCE:mutant phenotype:GO:0048193 Golgi vesicle transport [PMID:9755865]
note: v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28
codon start: 1
product: Gos1p
translation: MSSQPSFVTIRGKAISLETQTESLLSKYSTFAQTTSSEQTGQEKKIDKQLEGILGQRQDVIDSLTQICDSNPAISASKLSQLHRHKEILQDHWKSFRNIRSSIQQERNRLNLLFSVKNDIANSTTDAPAPIGDADEYIQNETRRIDQSNNVVDRLISQAWETRSQFHSQSNVLNTANNKVLQTLQRIPGVNQLIMKINTRRKKNAFVLATITTLCILFLFFTW
SIO_010081: YHL031C
subclass of: SO_0000673
so part of: YHL031C
location: complement(38815..39486)
location: region:38815-39486:-1
so has part: feature:38815-39486:-1:exon

NP_011832.1
type: Protein
SIO_000068: ncbiprotein

S000001023
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:38815-39486:-1:exon

YHL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM29
locus tag: YHL030W
so part of: sequence
location: <40084..>45690
location: region:40084-45690:1
so has part: feature:40084-45690:1:exon
subclass of: SO_0000010

856355
type: Gene
SIO_000068: ncbigene

position:40084:1
position: 40084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45690:1
position: 45690
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40084-45690:1:exon

YHL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM29
locus tag: YHL030W
product: Ecm29p
transcript id: NM_001179110.1
SIO_010081: YHL030W
subclass of: SO_0000673
so part of: YHL030W
location: <40084..>45690
location: region:40084-45690:1
so has part: feature:40084-45690:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40084-45690:1:exon

YHL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM29
locus tag: YHL030W
experiment: EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:12408819]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20620957|PMID:14562095|PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043248 proteasome assembly [PMID:20620957]
experiment: EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:20620957]
experiment: EXISTENCE:mutant phenotype:GO:0042030 ATPase inhibitor activity [PMID:23995839]
note: Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: Ecm29p
translation: MSISSDEAKEKQLVEKAELRLAIADSPQKFETNLQTFLPPLLLKLASPHASVRTAVFSALKNLISRINTLPQVQLPVRALIVQAKEPNLAAQQDSTNVRLYSLLLASKGIDRLSLQDRQQLLPLVVSNISCLTGTVAARMFHILLKLILEWVAPQESSHEQEEFVQFLQLDNDGFSFLMRQFTRFFLLVPSKQVQVSQQPLSRGYTCPGLSLTDVAFFTYDAGVTFNKEQLNKFKKAIFQFVCRGMAATQTIEQSPRMIELMEFLCVVSTDSTNLSDDAAQFMKRFPMPYENEEFITFLQTLYIGNTANGRPPVKAILQEKILSILNRSHFATTKAECISLICSIGLHSSEYKLRSLTLSFIRHVAKLNYKNLNPASSSPSSTDFSTCIVSLIRNNLHAEGWPKLQLGPQTPAFNTAILQRQLQYETLGDILKRDFELVSDLSYIEFLFESLKNDLPQFRSSIQESLLSLVGHLSILPQQSKLKLKNLLRKNLSIDEQQREDNNDAVNSIMALKFVSIKFTNAAFPFHDPEARLFNIWGTVRTNRFDIIEESFKGLQPFWFRVNNASINTSATVKTSDLLGSHLSETEFPPFREFLQVLIDQLDSEAASITRKSLNNAVRFSKQCLISNAIYGKKTMVIQDEDWSVRIDKALELDDTVVSRVNEMVQGMNDDIFIRYLTLLSNEFTATNSKGEQIAIFPYQDPIFGSVLLTLLNFVSNNVLRRLEILVPDLYHLVIMKFQSLSDNDLAVCATIIGIISTAIADSTHVKRITKIAQSQTMAETYVASYVVPRLYLKDQTNHIESDSILNLLNILTTHLSHPGTNKDMILKLVCQVTKFGLLLQVSAQERKDFLKKVMDTIQDKLINDVTAIQTWSYLSLYSTDLENSSLFQEKLLETNVSKQNDFLFSVGESLSVVAGKWSSKYLIKQIDIPNFNVEIMQQKFPATNVTTILDEIFSGCDSTKPSLRKASCIWLLSYIQYLGHLPEVSSKCNDIHLRFMRFLADRDEFIQDSAARGLSLVYEIGGSDLKESMVKGLLKSFTESTAGSASTSATGISGSVSEETELFEPGVLNTGDGSISTYKDILNLASEVGDPALVYKFMSLAKSSALWSSRKGIAFGLGAIMSKSSLEELLLKDQQTAKKLIPKLYRYRFDPFQAVSRSMTDIWNTLIPESSLTISLYFNDILDELLCGMANKEWRVREASTSALLQLIQSQPQEKFSEKMLKIWTMAFRTMDDIKDSVREVGTKFTTVLAKILARSIDVEKGVNPTKSKEILDNILPFLWGPHGLNSDAEEVRNFALTTLIDLVKHSPGAIKPFTPKLIYDFITLFSSIEPQVINYLALNAANYNIDANVIDTQRKNGVTNSPLFQTIEKLINNSDDCMMEEIINVVIKASRKSVGLPSKVASSLVIIILVKRYSIEMKPYSGKLLKVCLTMFEDRNESVNIAFAISMGYLFKVSALDKCIKYSEKLITKYFEPTSTENNKKVVGTAIDSILNYAKSEFDNVASVFMPLIFIACNDEDKDLETLYNKIWTEASSSGAGTVKLYLPEILNVLCVNIKSNDFSIRKTCAKSVIQLCGGINDSIPYPQIVKLFDISREALSGRSWDGKEHIVAALVSLTEKFSQTVADNNDLQESINHVMYTEVSRKSMKYVKKILPLYARYINVNPQEETITFLIEKAKEMIRLLGSESDDSEGSIKQTSDESTIKRIKPNTEITQKSSKENIENEEYVINLLKVSVDICNNSKSRYPMNLLEFIIDEIAYLFHNDRIIHTWRTQLAASEIGISIVGRFSTISSADFIQNVGRLWDQTFPINCNKETIENVKLQMIKFGGLIIQKIPSLQNNIEENLRLLNSIDSTSRIELELKNIGL
SIO_010081: YHL030W
subclass of: SO_0000673
so part of: YHL030W
location: 40084..45690
location: region:40084-45690:1
so has part: feature:40084-45690:1:exon

NP_011833.1
type: Protein
SIO_000068: ncbiprotein

S000001022
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40084-45690:1:exon

YHL029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OCA5
locus tag: YHL029C
so part of: sequence
location: complement(<45929..>47968)
location: region:45929-47968:-1
so has part: feature:45929-47968:-1:exon
subclass of: SO_0000010

856356
type: Gene
SIO_000068: ncbigene

position:45929:-1
position: 45929
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:47968:-1
position: 47968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45929-47968:-1:exon

YHL029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OCA5
locus tag: YHL029C
product: Oca5p
transcript id: NM_001179109.1
SIO_010081: YHL029C
subclass of: SO_0000673
so part of: YHL029C
location: complement(<45929..>47968)
location: region:45929-47968:-1
so has part: feature:45929-47968:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45929-47968:-1:exon

YHL029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OCA5
locus tag: YHL029C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts
codon start: 1
product: Oca5p
translation: MHDKKSPMANSHYLKNLKQQFRNKNLIETTIHLVKCNDHDSLAFLARTYGVPPQLRHVVWPILLKYHPMCISPNITSNTISWDPITNDFILNDPFLKSKAPTDKQDKSDDENILPYDIESIILHDLKKYFHSRSNPAGSSSNANTTNIATPTPVSSSDASTISSMEVLSPSLDYEFQIIETLKNAIVKFLLKWSKIFKYESGLAWIALGLAEWYPIYPYETMSPFNETHSFYEVEDYVVLSGRKHALLSTNNGNNGNSNSSSNNTNNNNTNITSGMHNLSINTNTSLHNSPYISHTLSYLYKEYPLPFELRSKLPTKPIFSFSALFERLALVILHCPDTILAHKQLKNDSNASSSSKANSNFNTNYFPIISGGDLSFQTQVFFKVFSSILPELYQPLTEESSLQPSSSRNSWIYWWLKCSGAKALQRQDRGRVWDLLLGWRPKPNMDTINFFLNYNDKKMDHLYHDTPQCDNEQYWMKDWIALYNNDPFWFPDLDSMALGSKKFPYDYSVFKELILRNRYGGTQSKAQKDNTVPSPGSDSNDKSELKLPFSSIDPHMQLIFIFIAILQFNEFKLLEFEEAEISEFLNNVPLLTKFDDSSYRKLYENTESSITSLPSSPTTSTMASLQSSSNSSAHISNYHMLIEVGNDAKASHCFDDLLNMAGDIWRKWLWRELEESSL
SIO_010081: YHL029C
subclass of: SO_0000673
so part of: YHL029C
location: complement(45929..47968)
location: region:45929-47968:-1
so has part: feature:45929-47968:-1:exon

NP_011834.1
type: Protein
SIO_000068: ncbiprotein

S000001021
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45929-47968:-1:exon

YHL028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YFW1
alternative label: YHC8
gene: WSC4
locus tag: YHL028W
gene synonym: YFW1; YHC8
so part of: sequence
location: <48763..>50580
location: region:48763-50580:1
so has part: feature:48763-50580:1:exon
subclass of: SO_0000010

856357
type: Gene
SIO_000068: ncbigene

position:48763:1
position: 48763
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:50580:1
position: 50580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48763-50580:1:exon

YHL028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YFW1
alternative label: YHC8
gene: WSC4
locus tag: YHL028W
gene synonym: YFW1; YHC8
product: Wsc4p
transcript id: NM_001179108.1
SIO_010081: YHL028W
subclass of: SO_0000673
so part of: YHL028W
location: <48763..>50580
location: region:48763-50580:1
so has part: feature:48763-50580:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48763-50580:1:exon

YHL028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YFW1
alternative label: YHC8
gene: WSC4
locus tag: YHL028W
gene synonym: YFW1; YHC8
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10196219]
experiment: EXISTENCE:genetic interaction:GO:0009408 response to heat [PMID:11589572]
experiment: EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:10196219]
experiment: EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:10196219]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:10196219]
note: Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
codon start: 1
product: Wsc4p
translation: MQTSMVSAKVSIWLVCSVICSSLVRATQSVCSSQNTATTDGVRNQFQSNGWCSNNCAGHQFAIVQGFMCWCSDSEPSTQTSVGDCSGTCPGYGYEDCGNADKDLFGYIYLGQTPLSSVQSVETSTESSVYVSSSSITSSSSTSIVDTTTISPTLTSTSTTPLTTASTSTTPSTDITSALPTTTSTKLSTSIPTSTTSSTSTTTSTSSSTSTTVSVTSSTSTTTSTTSSTLISTSTSSSSSSTPTTTSSAPISTSTTSSTSTSTSTTSPTSSSAPTSSSNTTPTSTTFTTTSPSTAPSSTTVTYTSTTASPITSTITSVNLQTSLKYSVITVTSVHTMDTNISEITSRYLTMKKVITQIYSSTLGATPTSAVATTSASVGGRITNNNNSNTTNSNTPTNKSTEKKGYWDSPGKIAATFVVVGVVCLVIICILIYLIHHYRTRPARKAQDFENEYQSKFYQSKYPNEVTTTTLHTPSPSSNSTFSTPRLIYTDEKGQIMSESPSPRQSTYSLTAGSPPNDPSTLASPFHDPILPRRTSTFLHSPIQKQHEKMESNVTLGEDTVLVDQRLDPSKMLNTLANDDATNHSTISLSDNVDYSRRVLRLMNE
SIO_010081: YHL028W
subclass of: SO_0000673
so part of: YHL028W
location: 48763..50580
location: region:48763-50580:1
so has part: feature:48763-50580:1:exon

NP_011835.1
type: Protein
SIO_000068: ncbiprotein

S000001020
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48763-50580:1:exon

YHL027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RIM1
gene: RIM101
locus tag: YHL027W
gene synonym: RIM1
so part of: sequence
location: <51111..>52988
location: region:51111-52988:1
so has part: feature:51111-52988:1:exon
subclass of: SO_0000010

856358
type: Gene
SIO_000068: ncbigene

position:51111:1
position: 51111
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52988:1
position: 52988
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:51111-52988:1:exon

YHL027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RIM1
gene: RIM101
locus tag: YHL027W
gene synonym: RIM1
product: alkaline-responsive transcriptional regulator RIM101
transcript id: NM_001179107.1
SIO_010081: YHL027W
subclass of: SO_0000673
so part of: YHL027W
location: <51111..>52988
location: region:51111-52988:1
so has part: feature:51111-52988:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:51111-52988:1:exon

YHL027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RIM1
gene: RIM101
locus tag: YHL027W
gene synonym: RIM1
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12509465]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20382759]
experiment: EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]
experiment: EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]
experiment: EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:19633265]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]
experiment: EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8417990]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8417990]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8367297]
experiment: EXISTENCE:mutant phenotype:GO:0071454 cellular response to anoxia [PMID:20402793]
experiment: EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:11050096]
note: Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression; involved in cell wall assembly; plays role in lager yeast flocculation under brewing conditions; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
codon start: 1
product: alkaline-responsive transcriptional regulator RIM101
translation: MVPLEDLLNKENGTAAPQHSRESIVENGTDVSNVTKKDGLPSPNLSKRSSDCSKRPRIRCTTEAIGLNGQEDERMSPGSTSSSCLPYHSTSHLNTPPYDLLGASAVSPTTSSSSDSSSSSPLAQAHNPAGDDDDADNDGDSEDITLYCKWDNCGMIFNQPELLYNHLCHDHVGRKSHKNLQLNCHWGDCTTKTEKRDHITSHLRVHVPLKPFGCSTCSKKFKRPQDLKKHLKIHLESGGILKRKRGPKWGSKRTSKKNKSCASDAVSSCSASVPSAIAGSFKSHSTSPQILPPLPVGISQHLPSQQQQRAISLNQLCSDELSQYKPVYSPQLSARLQTILPPLYYNNGSTVSQGANSRSMNVYEDGCSNKTIANATQFFTKLSRNMTNNYILQQSGGSTESSSSSGRIPVAQTSYVQPPNAPSYQSVQGGSSISATANTATYVPVRLAKYPTGPSLTEHLPPLHSNTAGGVFNRQSQYAMPHYPSVRAAPSYSSSGCSILPPLQSKIPMLPSRRTMAGGTSLKPNWEFSLNQKSCTNDIIMSKLAIEEVDDESEIEDDFVEMLGIVNIIKDYLLCCVMEDLDDEESEDKDEENAFLQESLEKLSLQNQMGTNSVRILTKYPKILV
SIO_010081: YHL027W
subclass of: SO_0000673
so part of: YHL027W
location: 51111..52988
location: region:51111-52988:1
so has part: feature:51111-52988:1:exon

NP_011836.1
type: Protein
SIO_000068: ncbiprotein

S000001019
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:51111-52988:1:exon

YHL026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL026C
so part of: sequence
location: complement(<53219..>54166)
location: region:53219-54166:-1
so has part: feature:53219-54166:-1:exon
subclass of: SO_0000010

856359
type: Gene
SIO_000068: ncbigene

position:53219:-1
position: 53219
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:54166:-1
position: 54166
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53219-54166:-1:exon

YHL026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL026C
product: uncharacterized protein
transcript id: NM_001179106.1
SIO_010081: YHL026C
subclass of: SO_0000673
so part of: YHL026C
location: complement(<53219..>54166)
location: region:53219-54166:-1
so has part: feature:53219-54166:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53219-54166:-1:exon

YHL026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL026C
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
codon start: 1
product: uncharacterized protein
translation: MKSSEPAPATPTGFRNSIWFIIFYLFVIQALGSAIISGGIEFAIAYAMYHSRVDLITLWAFPHTISGDCALSLFIQVGLTWASEEILVGFDDYKRPVFRLNKWITKPSPLKTESNEEIPPPKKRFIVDYFESKDNVVAKQNTLYHKHNWLFGYLEVNRGIIPKGKEATLKGFLTSQFIHDSTQSKFMNFIEWFVQKFIRSMILAIAMFIVIWPVTMGILAGIGHKVGSHDYYFNDYPLPQVMKLIYAVVIAFVCTPVAIIVIVLRNQFHEELYYEGLANGTLQQDQEVCSTGNRSSGSTDQDISTTKQQSQEAVA
SIO_010081: YHL026C
subclass of: SO_0000673
so part of: YHL026C
location: complement(53219..54166)
location: region:53219-54166:-1
so has part: feature:53219-54166:-1:exon

NP_011837.2
type: Protein
SIO_000068: ncbiprotein

S000001018
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53219-54166:-1:exon

YHL025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNF6
locus tag: YHL025W
so part of: sequence
location: <54851..>55849
location: region:54851-55849:1
so has part: feature:54851-55849:1:exon
subclass of: SO_0000010

856360
type: Gene
SIO_000068: ncbigene

position:54851:1
position: 54851
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55849:1
position: 55849
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:54851-55849:1:exon

YHL025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNF6
locus tag: YHL025W
product: Snf6p
transcript id: NM_001179105.1
SIO_010081: YHL025W
subclass of: SO_0000673
so part of: YHL025W
location: <54851..>55849
location: region:54851-55849:1
so has part: feature:54851-55849:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:54851-55849:1:exon

YHL025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNF6
locus tag: YHL025W
experiment: EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:23437238]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2188093|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:8016655|PMID:8127913|PMID:8159677]
experiment: EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:1459453]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1901413]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:23437238]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:17013386]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17013386]
experiment: EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:23437238]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1339306]
experiment: EXISTENCE:physical interaction:GO:0006289 nucleotide-excision repair [PMID:17013386]
note: Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions
codon start: 1
product: Snf6p
translation: MGVIKKKRSHHGKASRQQYYSGVQVGGVGSMGAINNNIPSLTSFAEENNYQYGYSGSSAGMNGRSLTYAQQQLNKQRQDFERVRLRPEQLSNIIHDESDTISFRSNLLKNFISSNDAFNMLSLTTVPCDRIEKSRLFSEKTIRYLMQKQHEMKTQAAELQEKPLTPLKYTKLIAAAEDGSRSTKDMIDAVFEQDSHLRYQPDGVVVHRDDPALVGKLRGDLREAPADYWTHAYRDVLAQYHEAKERIRQKEVTAGEAQDEASLQQQQQQDLQQQQQVVTTVASQSPHATATEKEPVPAVVDDPLENMFGDYSNEPFNTNFDDEFGDLDAVFF
SIO_010081: YHL025W
subclass of: SO_0000673
so part of: YHL025W
location: 54851..55849
location: region:54851-55849:1
so has part: feature:54851-55849:1:exon

NP_011838.1
type: Protein
SIO_000068: ncbiprotein

S000001017
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:54851-55849:1:exon

YHL024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIM4
locus tag: YHL024W
so part of: sequence
location: <56649..>58790
location: region:56649-58790:1
so has part: feature:56649-58790:1:exon
subclass of: SO_0000010

856361
type: Gene
SIO_000068: ncbigene

position:56649:1
position: 56649
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58790:1
position: 58790
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56649-58790:1:exon

YHL024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIM4
locus tag: YHL024W
product: Rim4p
transcript id: NM_001179104.1
SIO_010081: YHL024W
subclass of: SO_0000673
so part of: YHL024W
location: <56649..>58790
location: region:56649-58790:1
so has part: feature:56649-58790:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56649-58790:1:exon

YHL024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIM4
locus tag: YHL024W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:10806425]
experiment: EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:11713679]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:11713679]
experiment: EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:10806425]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11713679]
note: Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression
codon start: 1
product: Rim4p
translation: MKTEISTADSLRDPPSNGLKADSELVIREDIDQFLPSEVSSLGSDHQNDGEDSDTDSDNFLQDPEDDVDEESTGRGTVTTTSTSTESRGRPSSCIFVASLAAALSDDELCLSVTENFKKYGDLARVKVLRDNANRPYAFVQYNNDHDAKHALIRAQGTLLNGRRLRCEPAKVNRTLYLKNQQSIDFNEISQICEKFGGLEQIVPDRTDNQYTRRYTYPISSANSWFVQFVYRDDAIRAYANLRTDPNWIIEWAQNINVPKNYNLLHKSKFKSSKYHQNNGIINNDGSNNNDNNNSNNNNREDSRRNGDVIEEECGHVHGSDSEEKLTSDGIYDDEDKDSEITIDKRSIFVGQLDKETTREELNRRFSTHGKIQDINLIFKPTNIFAFIKYETEEAAAAALESENHAIFLNKTMHVQYKEVGGRHNRKFSGKNGGSNFNHHQFFSTRSGKTFTGPELNLAPPPINMYRKMSGGSQQESETMMPYMPMGPMPMGPPPPNAASLSDFDMFPPSYSTFMKGMMPLRRKSMPNSWSSPSSKSVNSENESVNGGDENSELPSEIPESSGRYNAANSFTTYNNSSAGNSNNNNNNNNSNSNKSQYKKRYARRSSYGYNEVPPKPYYFQPYYYHPMQYHMGPMGPLHPSQGSAGNHHPYMMVYPMSPPPPSGLDGSMIPPPINVSQSHAANHGSTHVHANEFISNDTGDINEDNKAYSLDY
SIO_010081: YHL024W
subclass of: SO_0000673
so part of: YHL024W
location: 56649..58790
location: region:56649-58790:1
so has part: feature:56649-58790:1:exon

NP_011839.1
type: Protein
SIO_000068: ncbiprotein

S000001016
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56649-58790:1:exon

YHL023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RMD11
gene: NPR3
locus tag: YHL023C
gene synonym: RMD11
so part of: sequence
location: complement(<59123..>62563)
location: region:59123-62563:-1
so has part: feature:59123-62563:-1:exon
subclass of: SO_0000010

856362
type: Gene
SIO_000068: ncbigene

position:59123:-1
position: 59123
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:62563:-1
position: 62563
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:59123-62563:-1:exon

YHL023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RMD11
gene: NPR3
locus tag: YHL023C
gene synonym: RMD11
product: Npr3p
transcript id: NM_001179103.1
SIO_010081: YHL023C
subclass of: SO_0000673
so part of: YHL023C
location: complement(<59123..>62563)
location: region:59123-62563:-1
so has part: feature:59123-62563:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:59123-62563:-1:exon

YHL023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RMD11
gene: NPR3
locus tag: YHL023C
gene synonym: RMD11
experiment: EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]
experiment: EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]
experiment: EXISTENCE:genetic interaction:GO:0010508 positive regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:genetic interaction:GO:0051058 negative regulation of small GTPase mediated signal transduction [PMID:23716719]
experiment: EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719|PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]
experiment: EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:18069899]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:19521502|PMID:23716719|PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]
note: Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog
codon start: 1
product: Npr3p
translation: MDECLPNSCLLGVHLVISTHSGPQIVYHYPPSNTAFLTNNPTKHQHLYGNHANLNKNTSTNKEEKLFNSGSTKTASQIALNESAKSYNTAITPSMTNTNTNNVTLPPTRSHANTVGSQSSIPAATNGVGYRKTDIEDTSRTFQYQETESETSSSGLSDSELSTDYLDISSDSFSISSSLSSSSLSSSPSSSSSSSPPQDGLSRTNSSFQSTDSMSPTSPQMIMENDSISVAESYLDSGTNNKSRAASKRSQNFFHKLSTKKSTDSKTHSPVRKLKSKPSQSTKKGNKLLKNTSNETDGNAFTGSCSISSKKSLSSTGEHNQELRNSSLNDTPGQSPHHYHHRYHHYHKNAATSQRNSHTQYDVEEEDMEVSAMLQDGKISMNEIFFEEENFQDINKILEFDNDFVAEFCSPEREMCNTRFEFTVDNFCFLGLPIHVDSQGRWRKSKHKNKTRSKRSSSTTTNISRKKSIASKISSLSENTLKKVNSGEADTVYDSNIGHEASTDTPNLRINTDVSGNEFEREKEDLGKNMNMFHVCFVMNPHLIEYNKRIDDMYQFVVTRLSLLLRYVQSKTSYISSECHIILKEKERVLKHSKTYQSIRGAGNKGKYLYQRILAKSSLARALTECVDKIQRNEIACLEINDDKVISLQIPIQNEFEKMPNFKLQPVLRGSYLTSILNMKFLEKSSLRIESQNRQNDQAQFSDTNNNIYRFGNNINSTGHCGAANVDDGDDNESNYYCDDNDDLLNYALLLLDEPNNIISSLETFSYQDDIGTIILKHLVRNIQPNIPLRSYRYLITDLLDNPSSLDDLTTETNSLESSILRSCALHLMYWRHARIVIPLSSKYTYIVSPLAPIQGYTIDDYKSTSQNDGNVKKMDDRENNKSGSDRVPLIYQNSMLFRSKFPSLPSLPIFLSLLSTDKPQAYSNIIPSREHKPVYLNALAWLIQYGYVTQLLTFINIRVDKHIKMAVDEDLEKEGFRKTNTARRPSMDYKKTDKKLDDEDGQSRDANASEACSGKNEGMQSNDNNKDVDEKDNENDSRVDDRDDNEIAIADEEEILHFEYDDPEMQHDYTIILEPERATAIEKRWLYRCIYGQPSDIQILFNKLLKYFNGKVPMELVIIKEEISRHDLKKLLNALDKYLIEIHHW
SIO_010081: YHL023C
subclass of: SO_0000673
so part of: YHL023C
location: complement(59123..62563)
location: region:59123-62563:-1
so has part: feature:59123-62563:-1:exon

NP_011840.1
type: Protein
SIO_000068: ncbiprotein

S000001015
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:59123-62563:-1:exon

YNCH0001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0001W
so part of: sequence
location: 62755..62826
location: region:62755-62826:1
so has part: feature:62755-62826:1:exon
subclass of: SO_0000663

856363
type: Gene
SIO_000068: ncbigene

position:62755:1
position: 62755
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:62826:1
position: 62826
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62755-62826:1:exon

YNCH0001W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0001W
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0001W
subclass of: SO_0000673
so part of: YNCH0001W
location: 62755..62826
location: region:62755-62826:1
so has part: feature:62755-62826:1:exon

S000006597
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62755-62826:1:exon

YHL022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO11
locus tag: YHL022C
so part of: sequence
location: complement(<62961..>64157)
location: region:62961-64157:-1
so has part: feature:62961-64157:-1:exon
subclass of: SO_0000010

856364
type: Gene
SIO_000068: ncbigene

position:62961:-1
position: 62961
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:64157:-1
position: 64157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62961-64157:-1:exon

YHL022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO11
locus tag: YHL022C
product: DNA topoisomerase (ATP-hydrolyzing)
transcript id: NM_001179102.1
SIO_010081: YHL022C
subclass of: SO_0000673
so part of: YHL022C
location: complement(<62961..>64157)
location: region:62961-64157:-1
so has part: feature:62961-64157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:62961-64157:-1:exon

YHL022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO11
locus tag: YHL022C
EC number: 5.6.2.2
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9039264]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23246437]
experiment: EXISTENCE:direct assay:GO:0045027 DNA end binding [PMID:9039264]
experiment: EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:2190690]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:8207053]
experiment: EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:2687110]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:2190690]
note: Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11
codon start: 1
product: DNA topoisomerase (ATP-hydrolyzing)
translation: MALEGLRKKYKTRQELVKALTPKRRSIHLNSNGHSNGTPCSNADVLAHIKHFLSLAANSLEQHQQPISIVFQNKKKKGDTSSPDIHTTLDFPLNGPHLCTHQFKLKRCAILLNLLKVVMEKLPLGKNTTVRDIFYSNVELFQRQANVVQWLDVIRFNFKLSPRKSLNIIPAQKGLVYSPFPIDIYDNILTCENEPKMQKQTIFPGKPCLIPFFQDDAVIKLGTTSMCNIVIVEKEAVFTKLVNNYHKLSTNTMLITGKGFPDFLTRLFLKKLEQYCSKLISDCSIFTDADPYGISIALNYTHSNERNAYICTMANYKGIRITQVLAQNNEVHNKSIQLLSLNQRDYSLAKNLIASLTANSWDIATSPLKNVIIECQREIFFQKKAEMNEIDARIFEYK
SIO_010081: YHL022C
subclass of: SO_0000673
so part of: YHL022C
location: complement(62961..64157)
location: region:62961-64157:-1
so has part: feature:62961-64157:-1:exon

NP_011841.1
type: Protein
SIO_000068: ncbiprotein

S000001014
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62961-64157:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS805; Autonomously Replicating Sequence
so part of: sequence
location: 64296..64371
location: region:64296-64371:1
so has part: feature:64296-64371:1:region

S000114849
type: SGD
SIO_000068: sgd

position:64296:1
position: 64296
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:64371:1
position: 64371
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64296-64371:1:region

YHL021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP12
gene: AIM17
locus tag: YHL021C
gene synonym: FMP12
so part of: sequence
location: complement(<64462..>65859)
location: region:64462-65859:-1
so has part: feature:64462-65859:-1:exon
subclass of: SO_0000010

856365
type: Gene
SIO_000068: ncbigene

position:64462:-1
position: 64462
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65859:-1
position: 65859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64462-65859:-1:exon

YHL021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP12
gene: AIM17
locus tag: YHL021C
gene synonym: FMP12
product: Aim17p
transcript id: NM_001179101.1
SIO_010081: YHL021C
subclass of: SO_0000673
so part of: YHL021C
location: complement(<64462..>65859)
location: region:64462-65859:-1
so has part: feature:64462-65859:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:64462-65859:-1:exon

YHL021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP12
gene: AIM17
locus tag: YHL021C
gene synonym: FMP12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19300474]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
codon start: 1
product: Aim17p
translation: MLRSNLCRGSRILARLTTTPRTYTSAATAAAANRGHIIKTYFNRDSTTITFSMEESSKPVSVCFNNVFLRDASHSAKLVTTGELYHNEKLTAPQDIQISEDGKSLVVKWKDGGHHQFPLQFFIDYKGSSFVSPATRKQESRYRPQLWNKRILKDNVKDLLSVSYNEFIDPKDDSKLFQTLVNLQKFGIAFISGTPSSSSEGLTIQKICERIGPIRSTVHGEGTFDVNASQATSVNAHYANKDLPLHTDLPFLENVPGFQILQSLPATEGEDPNTRPMNYFVDAFYATRNVRESDFEAYEALQIVPVNYIYENGDKRYYQSKPLIEHHDINEDNTLLGNYEALIKCINYSPPYQAPFTFGIYDKPSDLNNNLDLNLITTPAKLTERFLFKSFIRGLNLFESHINDFNNQFRLQLPENCCVIFNNRRILHANSLTSSNQQWLKGCYFDSDTFKSKLKFLEEKFPHDK
SIO_010081: YHL021C
subclass of: SO_0000673
so part of: YHL021C
location: complement(64462..65859)
location: region:64462-65859:-1
so has part: feature:64462-65859:-1:exon

NP_011842.1
type: Protein
SIO_000068: ncbiprotein

S000001013
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:64462-65859:-1:exon

YHL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OPI1
locus tag: YHL020C
so part of: sequence
location: complement(<66242..>67456)
location: region:66242-67456:-1
so has part: feature:66242-67456:-1:exon
subclass of: SO_0000010

856366
type: Gene
SIO_000068: ncbigene

position:66242:-1
position: 66242
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:67456:-1
position: 67456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:66242-67456:-1:exon

YHL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OPI1
locus tag: YHL020C
product: transcriptional regulator OPI1
transcript id: NM_001179100.1
SIO_010081: YHL020C
subclass of: SO_0000673
so part of: YHL020C
location: complement(<66242..>67456)
location: region:66242-67456:-1
so has part: feature:66242-67456:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:66242-67456:-1:exon

YHL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OPI1
locus tag: YHL020C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15192221|PMID:15455074|PMID:27663510]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15192221]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15455074]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15192221]
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:15455074]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:27480805]
experiment: EXISTENCE:direct assay:GO:0071072 negative regulation of phospholipid biosynthetic process [PMID:27743455]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:1985968]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:1985968]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12871953]
experiment: EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:11454208]
note: Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid
codon start: 1
product: transcriptional regulator OPI1
translation: MSENQRLGLSEEEVEAAEVLGVLKQSCRQKSQPSEDVSQADKMPASESSTTPLNILDRVSNKIISNVVTFYDEINTNKRPLKSIGRLLDDDDDEHDDYDYNDDEFFTNKRQKLSRAIAKGKDNLKEYKLNMSIESKKRLVTCLHLLKLANKQLSDKISCLQDLVEKEQVHPLHKQDGNARTTTGAGEDETSSDEDDDDEEFFDASEQVNASEQSIVVKMEVVGTVKKVYSLISKFTANSLPEPARSQVRESLLNLPTNWFDSVHSTSLPHHASFHYANCEEQKVEQQQQQQQQQQQQQLLQQQLLQQQQQKRNKDGDDSASPSSSVTANGKVLILAKESLEMVRNVMGVVDSTLGKAEEWVKQKQEVKEMIRERFLQQQQQYRQQQQKDGNYVKPSQDNVDSKD
SIO_010081: YHL020C
subclass of: SO_0000673
so part of: YHL020C
location: complement(66242..67456)
location: region:66242-67456:-1
so has part: feature:66242-67456:-1:exon

NP_011843.1
type: Protein
SIO_000068: ncbiprotein

S000001012
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:66242-67456:-1:exon

YHL019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APM2
locus tag: YHL019C
so part of: sequence
location: complement(<67731..>69548)
location: region:67731-69548:-1
so has part: feature:67731-69548:-1:exon
subclass of: SO_0000010

856367
type: Gene
SIO_000068: ncbigene

position:67731:-1
position: 67731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:69548:-1
position: 69548
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67731-69548:-1:exon

YHL019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APM2
locus tag: YHL019C
product: Apm2p
transcript id: NM_001179099.1
SIO_010081: YHL019C
subclass of: SO_0000673
so part of: YHL019C
location: complement(<67731..>69548)
location: region:67731-69548:-1
so has part: feature:67731-69548:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:67731-69548:-1:exon

YHL019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APM2
locus tag: YHL019C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005769 early endosome [PMID:26658609]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:26658609]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]
note: hypothetical protein; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
codon start: 1
product: Apm2p
translation: MSSSLFILDENLEPLVSKNIRALPNLSSVLSSFKQCYHDGSPPILSQNDWFFIHLKRDFLHFVSVIHTTDKPNIDLMTILAFLEQFYHLLQKYFEIEVLTKNVILDNILLVLELIDECIDFGIVQVTDPSIIKDYIRVKVNVPRVTVDNEEWSPGEESSSSSGSDSDSEYSNTNKRKDKKKKRKKKKGTKGKSVGKSKLKSIMVNNKENRGINVVETVKETLRNKNDTGKEAANDELPNDGNDLYINGDIAKTIIMPISWRTKGIHYAKNEFFLDVIERVQYLMDFEKGVIRKNLIHGEIVCRCYLSGMPKLKISINKILNRDPQFMSNSSFHQCVSLDSINTIEKDEEKNSDDDAGLQAATDAREIEFIPPDGEFVLCQYELKRHVKDAPMVRLKDFEIKPKLKKFKIQIVTKIQTNFKPTNSTSKLNVRIPLTKVFQEYKIDLSKQIRFKANIGKVVFNLSDDFLLWEIQTMKGHREHSTNKSSQYNSDEDDPNTCASMVAEFPLFNQEEYDRLQEEMKTSMNPPPLRTGPRLEELYRQVHDQQTSHVTPRDKLVNIDFEIPYCTCSGLKVEYLKVEEPQLQYQSFPWVRYKTVSDEEYAYIV
SIO_010081: YHL019C
subclass of: SO_0000673
so part of: YHL019C
location: complement(67731..69548)
location: region:67731-69548:-1
so has part: feature:67731-69548:-1:exon

NP_011844.1
type: Protein
SIO_000068: ncbiprotein

S000001011
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67731-69548:-1:exon

YHL018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCO14
locus tag: YHL018W
so part of: sequence
location: <69708..>70070
location: region:69708-70070:1
so has part: feature:69708-70070:1:exon
subclass of: SO_0000010

856368
type: Gene
SIO_000068: ncbigene

position:69708:1
position: 69708
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70070:1
position: 70070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:69708-70070:1:exon

YHL018W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCO14
locus tag: YHL018W
product: 4a-hydroxytetrahydrobiopterin dehydratase
transcript id: NM_001179098.1
SIO_010081: YHL018W
subclass of: SO_0000673
so part of: YHL018W
location: <69708..>70070
location: region:69708-70070:1
so has part: feature:69708-70070:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:69708-70070:1:exon

YHL018W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCO14
locus tag: YHL018W
EC number: 4.2.1.96
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
codon start: 1
product: 4a-hydroxytetrahydrobiopterin dehydratase
translation: MHNKIVRIASSALTGGKLLEKLKPLTRWEVQWDPNKTKCLGITREVTFKDYETTWAFLTRVSMRSHLWGHHPLIHTSYTWVKLELHTHDIDPKDGAHSQLSDIDVRMAKRIDSYIDEMTT
SIO_010081: YHL018W
subclass of: SO_0000673
so part of: YHL018W
location: 69708..70070
location: region:69708-70070:1
so has part: feature:69708-70070:1:exon

NP_011845.1
type: Protein
SIO_000068: ncbiprotein

S000001010
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:69708-70070:1:exon

YHL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL017W
so part of: sequence
location: <70276..>71874
location: region:70276-71874:1
so has part: feature:70276-71874:1:exon
subclass of: SO_0000010

856369
type: Gene
SIO_000068: ncbigene

position:70276:1
position: 70276
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:71874:1
position: 71874
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70276-71874:1:exon

YHL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL017W
product: uncharacterized protein
transcript id: NM_001179097.1
SIO_010081: YHL017W
subclass of: SO_0000673
so part of: YHL017W
location: <70276..>71874
location: region:70276-71874:1
so has part: feature:70276-71874:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70276-71874:1:exon

YHL017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL017W
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MDRTWLLLTWLLLLCGVVQGNQESINQKYHDVCSGMYSKEDFNGKVDPYISFTLEELSLADEDDDGEGVSVAVFDFQDYEHIGVRLPNGEIQYICDDYALDLGLCEDSSEGQFIIQETAIDPFTSKEHKLTSQILTFTQQELGTNDKVYSINKTGYYCVTTSSFISSSSKFKATVNFRNAYGQLDASEAYKMPIYAFLAVAYAVCTLVYSWLCWKHRHELLPLQRYILVFCIFLTADTIFVWMYYIIENQKGNSSVALHVYMVFISIFSAGKMTFTLLLALLISLGYGIVYPKLDRTLLRRCQIFAIFTFAVCVAFLVQKYSQNSESLSNLILITAIPLVLCLFAFYYLTLSSMNKTMTYLREQNQVVKLNMYRKLIILCYISLFILFLGLLVSTFAYVGMDTVDMIEQYWKTEFLITDTWPSFVYFLVFVIFAFFWRPTSTSYLLACSHQLPTDMENVSEFDLDDINSLSDEALPNREPRNDYQEHDHNMDIDLASDFEEVPSVNANTNANNDVLFDVDYDRDAKNDRSTT
SIO_010081: YHL017W
subclass of: SO_0000673
so part of: YHL017W
location: 70276..71874
location: region:70276-71874:1
so has part: feature:70276-71874:1:exon

NP_011846.1
type: Protein
SIO_000068: ncbiprotein

S000001009
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70276-71874:1:exon

YHL016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUR3
locus tag: YHL016C
so part of: sequence
location: complement(<72037..>74244)
location: region:72037-74244:-1
so has part: feature:72037-74244:-1:exon
subclass of: SO_0000010

856370
type: Gene
SIO_000068: ncbigene

position:72037:-1
position: 72037
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:74244:-1
position: 74244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:72037-74244:-1:exon

YHL016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUR3
locus tag: YHL016C
product: Dur3p
transcript id: NM_001179096.1
SIO_010081: YHL016C
subclass of: SO_0000673
so part of: YHL016C
location: complement(<72037..>74244)
location: region:72037-74244:-1
so has part: feature:72037-74244:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:72037-74244:-1:exon

YHL016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUR3
locus tag: YHL016C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17218313]
experiment: EXISTENCE:direct assay:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]
experiment: EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]
experiment: EXISTENCE:direct assay:GO:0015847 putrescine transport [PMID:17218313]
experiment: EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:17218313]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8335627]
experiment: EXISTENCE:mutant phenotype:GO:0015204 urea transmembrane transporter activity [PMID:8335627]
experiment: EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]
experiment: EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]
experiment: EXISTENCE:mutant phenotype:GO:0015840 urea transport [PMID:8335627]
experiment: EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:17218313]
experiment: EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:17218313]
note: Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
codon start: 1
product: Dur3p
translation: MGEFKPPLPQGAGYAIVLGLGAVFAGMMVLTTYLLKRYQKEIITAEEFTTAGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIFGGYAYAAGACFQIIAFAILAIKTKQMAPNAHTYLELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATSDVLGSPGKVYDLVREAAKRHPVDGNYQGEYMTMTSKSAGILLIINLIGNFGTVFLDNGYWNKAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVETSPNFPTYPDPLTSFQANSGLVLPAAAIAIMGKGGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRASGKKLIYTSHVACIFFGLAMSGFSVGLYYGGISMGYIYEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSPILGTGLAIMSWLVCTKSLYKELTVDTTFMDYPMLTGNLVALLSPAIFIPILTYVFKPQNFDWEKMKDITRVDETAELVQADPDIQLYDAEANDKEQEEETNSLVSDSEKNDVRVNNEKLIEPNLGVVISNAIFQEDDTQLQNELDEEQRELARGLKIAYFLCVFFALAFLVVWPMPMYGSKYIFSKKFFTGWVVVMIIWLFFSAFAVCIYPLWEGRHGIYTTLRGLYWDLSGQTYKLREWQNSNPQDLHVVTSQISARAHRQSSHFGQVDEII
SIO_010081: YHL016C
subclass of: SO_0000673
so part of: YHL016C
location: complement(72037..74244)
location: region:72037-74244:-1
so has part: feature:72037-74244:-1:exon

NP_011847.1
type: Protein
SIO_000068: ncbiprotein

S000001008
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:72037-74244:-1:exon

YHL015W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL015W-A
so part of: sequence
location: <74699..>74782
location: region:74699-74782:1
so has part: feature:74699-74782:1:exon
subclass of: SO_0000010

1466525
type: Gene
SIO_000068: ncbigene

position:74699:1
position: 74699
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:74782:1
position: 74782
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:74699-74782:1:exon

YHL015W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL015W-A
product: uncharacterized protein
transcript id: NM_001184649.1
SIO_010081: YHL015W-A
subclass of: SO_0000673
so part of: YHL015W-A
location: <74699..>74782
location: region:74699-74782:1
so has part: feature:74699-74782:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:74699-74782:1:exon

YHL015W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL015W-A
codon start: 1
product: uncharacterized protein
translation: MTAFASLREPLVLANLKIKVHIYRMKR
SIO_010081: YHL015W-A
subclass of: SO_0000673
so part of: YHL015W-A
location: 74699..74782
location: region:74699-74782:1
so has part: feature:74699-74782:1:exon

NP_878085.1
type: Protein
SIO_000068: ncbiprotein

S000028828
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:74699-74782:1:exon

YHL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: URP2
gene: RPS20
locus tag: YHL015W
gene synonym: URP2
so part of: sequence
location: <75412..>75777
location: region:75412-75777:1
so has part: feature:75412-75777:1:exon
subclass of: SO_0000010

856371
type: Gene
SIO_000068: ncbigene

position:75412:1
position: 75412
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:75777:1
position: 75777
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:75412-75777:1:exon

YHL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: URP2
gene: RPS20
locus tag: YHL015W
gene synonym: URP2
product: ribosomal 40S subunit protein S20
transcript id: NM_001179095.1
SIO_010081: YHL015W
subclass of: SO_0000673
so part of: YHL015W
location: <75412..>75777
location: region:75412-75777:1
so has part: feature:75412-75777:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:75412-75777:1:exon

YHL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: URP2
gene: RPS20
locus tag: YHL015W
gene synonym: URP2
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
codon start: 1
product: ribosomal 40S subunit protein S20
translation: MSDFQKEKVEEQEQQQQQIIKIRITLTSTKVKQLENVSSNIVKNAEQHNLVKKGPVRLPTKVLKISTRKTPNGEGSKTWETYEMRIHKRYIDLEAPVQIVKRITQITIEPGVDVEVVVASN
SIO_010081: YHL015W
subclass of: SO_0000673
so part of: YHL015W
location: 75412..75777
location: region:75412-75777:1
so has part: feature:75412-75777:1:exon

NP_011848.1
type: Protein
SIO_000068: ncbiprotein

S000001007
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:75412-75777:1:exon

YHL014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YLF1
gene: YLF2
locus tag: YHL014C
gene synonym: YLF1
so part of: sequence
location: complement(<76097..>77314)
location: region:76097-77314:-1
so has part: feature:76097-77314:-1:exon
subclass of: SO_0000010

856372
type: Gene
SIO_000068: ncbigene

position:76097:-1
position: 76097
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77314:-1
position: 77314
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:76097-77314:-1:exon

YHL014C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YLF1
gene: YLF2
locus tag: YHL014C
gene synonym: YLF1
product: Ylf2p
transcript id: NM_001179094.1
SIO_010081: YHL014C
subclass of: SO_0000673
so part of: YHL014C
location: complement(<76097..>77314)
location: region:76097-77314:-1
so has part: feature:76097-77314:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:76097-77314:-1:exon

YHL014C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YLF1
gene: YLF2
locus tag: YHL014C
gene synonym: YLF1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
note: hypothetical protein; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Ylf2p
translation: MNIGGGKFLLGRISNNPTSGIVGLANVGKSTFFQAITNSKLGNPANYPFATIDAECAKVNIPSVPLSNLLRIYQSAKCVPGTLTIYDIAGLTRGASQGHGLGNKFLNDIRHVEGIFQVVRGFLKEDITHIEGNVDPVRDLSVVQDELILKDLEFLENIRERLSKKMRMVSKNSKEHQEMKIETELLDALEEHLFNGKKIRHFKDHWNLDEVKILNKHNFLTSKPTLILLNVSPQDYVRNENKFVRNIIEWINEFSPGDKFLLFSAEFESQLMECKGIASEYFDKIKEDTNVSDQQLVSAIPQIILEMRKLLNLISFFTCGPQEVHQWNIREGTTAQEAAGVIHSDLRETFISADVIKYDDLKKMEPPLNESLLKSKGLIKRAGKQYIMQDNDIALFKAAGGKIKK
SIO_010081: YHL014C
subclass of: SO_0000673
so part of: YHL014C
location: complement(76097..77314)
location: region:76097-77314:-1
so has part: feature:76097-77314:-1:exon

NP_011849.1
type: Protein
SIO_000068: ncbiprotein

S000001006
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:76097-77314:-1:exon

YHL013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OTU2
locus tag: YHL013C
so part of: sequence
location: complement(<77430..>78353)
location: region:77430-78353:-1
so has part: feature:77430-78353:-1:exon
subclass of: SO_0000010

856373
type: Gene
SIO_000068: ncbigene

position:77430:-1
position: 77430
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:78353:-1
position: 78353
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:77430-78353:-1:exon

YHL013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OTU2
locus tag: YHL013C
product: Otu2p
transcript id: NM_001179093.1
SIO_010081: YHL013C
subclass of: SO_0000673
so part of: YHL013C
location: complement(<77430..>78353)
location: region:77430-78353:-1
so has part: feature:77430-78353:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:77430-78353:-1:exon

YHL013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OTU2
locus tag: YHL013C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
codon start: 1
product: Otu2p
translation: MTGMESGENLENMEDILARHRKENKDLQNKITGMKKQATKSKRKEVNSKCLDLQDKLKTKQENEIRDWKIANNEVFDAEQEDEVTPEKLLEQLSISRDEKEQQNVPVQQQQQGQTKKRRNRQKERLAKRDAAIAKMKEEAALEASKQPDLKKMEQESIDQLCELKKLKQFDIQPDGHCLFASILDQLKLRHDPKKLDQDMDVMKLRWLSCNYVQEHRDDFIPYLFDEETMKMKDIDEYTKEMEHTAQWGGEIEILALSHVFDCPISILMSGRPIQVYNECGKNPELKLVYYKHSYALGEHYNSLHDS
SIO_010081: YHL013C
subclass of: SO_0000673
so part of: YHL013C
location: complement(77430..78353)
location: region:77430-78353:-1
so has part: feature:77430-78353:-1:exon

NP_011850.1
type: Protein
SIO_000068: ncbiprotein

S000001005
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:77430-78353:-1:exon

YHL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL012W
so part of: sequence
location: <78936..>80417
location: region:78936-80417:1
so has part: feature:78936-80417:1:exon
subclass of: SO_0000010

856374
type: Gene
SIO_000068: ncbigene

position:78936:1
position: 78936
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80417:1
position: 80417
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78936-80417:1:exon

YHL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL012W
product: UTP--glucose-1-phosphate uridylyltransferase
transcript id: NM_001179092.1
SIO_010081: YHL012W
subclass of: SO_0000673
so part of: YHL012W
location: <78936..>80417
location: region:78936-80417:1
so has part: feature:78936-80417:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78936-80417:1:exon

YHL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL012W
EC number: 2.7.7.9
note: Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
codon start: 1
product: UTP--glucose-1-phosphate uridylyltransferase
translation: MTVFSGVNKIEFEGTFEGIGKDVVMSQMIRALQKHFPSIRDKNYEFSLFLHIFQRYVLENTSITHDLVCDKIRLPIIDEVVELDDIKNYGLLEGKLLSKLAILKLTGKANPIIGKESPLFEVKNGMSSLDVIVRQTQNLNVRYNSDVPLIFMTSLETESQVSNFLEEHYSSSKVRWKTVVQSSFPQIDKDRLLPIDLQINSHENDFWYPCGTGNLTDTLYFSGELDKLIAQGKEILFVSNVDNLGATGDLNILNFIINEKIEYLVEVVERTANVSNTGVLATYKGKLRSVYYNCLSNESASTCRIVNTNNIWIDLKKLKVLIESNSLNLPIHSSESKITHKNEEIECLQFKTQLVDCIAFFPNSRVLKVSRDRFLPLRTCKDLFLLKSTLYDLDSNGTFNLYPLKFGLLPSIDLGDEFATYETFKIGVPDIPNILELEHLTVMGNVFFGRNITLKGTVIIICDENDVITVPDGSILENVTIWHKSQLEDMNGY
SIO_010081: YHL012W
subclass of: SO_0000673
so part of: YHL012W
location: 78936..80417
location: region:78936-80417:1
so has part: feature:78936-80417:1:exon

NP_011851.1
type: Protein
SIO_000068: ncbiprotein

S000001004
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78936-80417:1:exon

YHL011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRS3
locus tag: YHL011C
so part of: sequence
location: complement(<80654..>81616)
location: region:80654-81616:-1
so has part: feature:80654-81616:-1:exon
subclass of: SO_0000010

856375
type: Gene
SIO_000068: ncbigene

position:80654:-1
position: 80654
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:81616:-1
position: 81616
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80654-81616:-1:exon

YHL011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRS3
locus tag: YHL011C
product: ribose phosphate diphosphokinase subunit PRS3
transcript id: NM_001179091.1
SIO_010081: YHL011C
subclass of: SO_0000673
so part of: YHL011C
location: complement(<80654..>81616)
location: region:80654-81616:-1
so has part: feature:80654-81616:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80654-81616:-1:exon

YHL011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRS3
locus tag: YHL011C
EC number: 2.7.6.1
experiment: EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]
experiment: EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]
experiment: EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:15470112]
note: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
codon start: 1
product: ribose phosphate diphosphokinase subunit PRS3
translation: MPTNSIKLLAPDVHRGLAELVAKRLGLQLTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGSGVVNDRVLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKENVNYMDSIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKNYPL
SIO_010081: YHL011C
subclass of: SO_0000673
so part of: YHL011C
location: complement(80654..81616)
location: region:80654-81616:-1
so has part: feature:80654-81616:-1:exon

NP_011852.1
type: Protein
SIO_000068: ncbiprotein

S000001003
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80654-81616:-1:exon

YHL010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ETP1
locus tag: YHL010C
so part of: sequence
location: complement(<81964..>83721)
location: region:81964-83721:-1
so has part: feature:81964-83721:-1:exon
subclass of: SO_0000010

856376
type: Gene
SIO_000068: ncbigene

position:81964:-1
position: 81964
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:83721:-1
position: 83721
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81964-83721:-1:exon

YHL010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ETP1
locus tag: YHL010C
product: Etp1p
transcript id: NM_001179090.1
SIO_010081: YHL010C
subclass of: SO_0000673
so part of: YHL010C
location: complement(<81964..>83721)
location: region:81964-83721:-1
so has part: feature:81964-83721:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81964-83721:-1:exon

YHL010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ETP1
locus tag: YHL010C
experiment: EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:9497340]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16564012]
experiment: EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:19416103]
note: hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
codon start: 1
product: Etp1p
translation: MDQFEYIITLEFGNQNQVESAYQIFKSIPKKLKAKSIGEESIKSNNQDWQDWRVCDLEIDMITDFKNQTSKEEESDLITSQYLGHGIIRLFKLSNANNTLNEKEILTIPGDDTMICILFVPTYFTVHDLLHFYIGDDIVNKQVSNFRILRNQQKGMGFNFTVLIKFRNALDAKNFKEEFNGKSFSRMDPETCHVISVKEIVFQKKLFQRPAANEDFPYLLTDPFTVKKKKELVKVELPTCPVCLERMDSETTGLVTIPCQHTFHCQCLNKWKNSRCPVCRHSSLRLSRESLLKQAGDSAHCATCGSTDNLWICLICGNVGCGRYNSKHAIKHYEETLHCFAMDIRTQRVWDYAGDNYVHRLVQNEVDGKLVEVGGSGDDDNNDIGNSDELQNVVYGNRSKNGEKSNSNKKDGELAANFLRHREYHLEYVQVLISQLESQREYYELKLQEKDQTASDSSNVESLKKSMEDLKLQFQVTQKEWQKREMAQKSKLEEDMLVIEGLQANLDHLSKKQEQLERENKALEESKQDLEEQVKDLMFYLDSQEKFKDADESVKEGTILIQQPHGAAQASKSKKKRNKNKKAGK
SIO_010081: YHL010C
subclass of: SO_0000673
so part of: YHL010C
location: complement(81964..83721)
location: region:81964-83721:-1
so has part: feature:81964-83721:-1:exon

NP_011853.1
type: Protein
SIO_000068: ncbiprotein

S000001002
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81964-83721:-1:exon

YHL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YAP3
locus tag: YHL009C
so part of: sequence
location: complement(<84068..>85060)
location: region:84068-85060:-1
so has part: feature:84068-85060:-1:exon
subclass of: SO_0000010

856377
type: Gene
SIO_000068: ncbigene

position:84068:-1
position: 84068
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85060:-1
position: 85060
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84068-85060:-1:exon

YHL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YAP3
locus tag: YHL009C
product: Yap3p
transcript id: NM_001179089.1
SIO_010081: YHL009C
subclass of: SO_0000673
so part of: YHL009C
location: complement(<84068..>85060)
location: region:84068-85060:-1
so has part: feature:84068-85060:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84068-85060:-1:exon

YHL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YAP3
locus tag: YHL009C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9372930]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9372930]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9372930]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
note: Basic leucine zipper (bZIP) transcription factor
codon start: 1
product: Yap3p
translation: MTPSNMDDNTSGFMKFINPQCQEEDCCIRNSLFQEDSKCIKQQPDLLSEQTAPFPILEDQCPALNLDRSNNDLLLQNNISFPKGSDLQAIQLTPISGDYSTYVMADNNNNDNDSYSNTNYFSKNNGISPSSRSPSVAHNENVPDDSKAKKKAQNRAAQKAFRERKEARMKELQDKLLESERNRQSLLKEIEELRKANTEINAENRLLLRSGNENFSKDIEDDTNYKYSFPTKDEFFTSMVLESKLNHKGKYSLKDNEIMKRNTQYTDEAGRHVLTVPATWEYLYKLSEERDFDVTYVMSKLQGQECCHTHGPAYPRSLIDFLVEEATLNE
SIO_010081: YHL009C
subclass of: SO_0000673
so part of: YHL009C
location: complement(84068..85060)
location: region:84068-85060:-1
so has part: feature:84068-85060:-1:exon

NP_011854.1
type: Protein
SIO_000068: ncbiprotein

S000001001
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84068-85060:-1:exon

YNCH0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0002C
so part of: sequence
location: complement(85298..85371)
location: region:85298-85371:-1
so has part: feature:85298-85371:-1:exon
subclass of: SO_0000663

856378
type: Gene
SIO_000068: ncbigene

position:85298:-1
position: 85298
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:85371:-1
position: 85371
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85298-85371:-1:exon

YNCH0002C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0002C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0002C
subclass of: SO_0000673
so part of: YNCH0002C
location: complement(85298..85371)
location: region:85298-85371:-1
so has part: feature:85298-85371:-1:exon

S000006758
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85298-85371:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(85388..85538)
location: region:85388-85538:-1
so has part: feature:85388-85538:-1:region

S000006987
type: SGD
SIO_000068: sgd

position:85388:-1
position: 85388
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:85538:-1
position: 85538
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85388-85538:-1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YHLWTy4-1; Ty4 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YHLWTy4-1
so part of: sequence
location: 85539..91761
location: region:85539-91761:1
so has part: feature:85539-91761:1:region

S000006991
type: SGD
SIO_000068: sgd

position:85539:1
position: 85539
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:91761:1
position: 91761
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85539-91761:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 85539..85909
location: region:85539-85909:1
so has part: feature:85539-85909:1:region

S000006989
type: SGD
SIO_000068: sgd

position:85909:1
position: 85909
reference: sequence
type: ForwardStrandPosition
type: ExactPosition
type: FuzzyPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85539-85909:1:region

YHL009W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL009W-B
so part of: sequence
location: <85909..>91318
location: region:85909-91318:1
so has part: feature:85909-91318:1:exon
subclass of: SO_0000010

856380
type: Gene
SIO_000068: ncbigene

position:91318:1
position: 91318
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85909-91318:1:exon

YHL009W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL009W-B
product: gag-pol fusion protein
transcript id: NM_001184404.2
SIO_010081: YHL009W-B
subclass of: SO_0000673
so part of: YHL009W-B
location: <85909..>91318
location: region:85909-91318:1
so has part: feature:85909-91318:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85909-91318:1:exon

YHL009W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL009W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MATPVRDETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIKDEQVKQYQRNLNRFKTILNGLKAEEEKLSETDDIQMLAEKLLKLGETIDKVENRIVDLVEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPILLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRIIDGLKNKYRSLHGRDVRIRAWEKVLVDTTCRNSALLMNKLQKLVLMEKWIFSKCCQDCPNLKDYLQEAIMGTLHESLRNSVKQRLYNIPHNVGINHEEFLINTVIETVIDLSPIADDQIENSCMYCKSVFHCSINCKKKPNRELGLTRPISQKPIIYKVHRDNNNLSPVQNEQKSWNKTQKKSNKVYNSKKLVIIDTGSGVNITNDKTLLHNYEDSNRSTRFFGIGKNSSVSVKGYGYIKIKNGHNNTDNKCLLTYYVPEEESTIISCYDLAKKTKMVLSRKYTRLGNKIIKIKTKIVNGVIHVKMNELIERPSDDSKINAIKPTSSPGFKLNKRSITLEDAHKRMGHTGIQQIENSIKHNHYEESLDLIKEPNEFWCQTCKISKATKRNHYTGSMNNHSTDHEPGSSWCMDIFGPVSSSNADTKRYMLIMVDNNTRYCMTSTHFNKNAETILAQIRKNIQYVETQFDRKVREINSDRGTEFTNDQIEEYFISKGIHHILTSTQDHAANGRAERYIRTIVTDATTLLRQSNLRVKFWEYAVTSATNIRNCLEHKSTGKLPLKAISRQPVTVRLMSFLPFGEKGIIWNHNHKKLKPSGLPSIILCKDPNSYGYKFFIPSKNKIVTSDNYTIPNYTMDGRVRNTQNIYKSHQFSSHNDNEEDQIETVTNLCEALENYEDDNKPITRLEDLFTEEELSQIDSNAKYPSPSNNLEGDLDYVFSDVEESGDYDVESELSTTNTSISTDKNKILSNKDFNSELASTEISISEIDKKGLINTSHIDEDKYDEKVHRIPSIIQEKLVGSKNTIKINDENRISDRIRSKNIGSILNTGLSRCVDITDESITNKDESMHNAKPELIQEQFNKTNHETSFPKEGSIGTNVKFRNTDNEISLKTGDTSLPIKTLESINNHHSNDYSTNKVEKFEKENHHPPPIEDIVDMSDQTDMESNCQDGNNLKELKVTDKNVPTDNGTNVSPRLEQNIEASGSPVQTVNKSAFLNKEFSSLNMKRKRKRHDKNNSLTSYELERDKKRSKRNRVKLIPDNMETVSAQKIRAIYYNEAISKNPDLKEKHEYKQAYHKELQNLKDMKVFDVDVKYSRSEIPDNLIVPTNTIFTKKRNGIYKARIVCRGDTQSPDTYSVITTESLNHNHIKIFLMIANNRNMFMKTLDINHAFLYAKLEEEIYIPHPHDRRCVVKLNKALYGLKQSPKEWNDHLRQYLNGIGLKDNSYTPGLYQTEDKNLMIAVYVDDCVIAASNEQRLDEFINKLKSNFELKITGTLIDDVLDTDILGMDLVYNKRLGTIDLTLKSFINRMDKKYNEELKKIRKSSIPHMSTYKIDPKKDVLQMSEEEFRQGVLKLQQLLGELNYVRHKCRYDINFAVKKVARLVNYPHERVFYMIYKIIQYLVRYKDIGIHYDRDCNKDKKVIAITDASVGSEYDAQSRIGVILWYGMNIFNVYSNKSTNRCVSSTEAELHAIYEGYADSETLKVTLKELGEGDNNDIVMITDSKPAIQGLNRSYQQPKEKFTWIKTEIIKEKIKEKSIKLLKITGKGNIADLLTKPVSASDFKRFIQVLKNKITSQDILASTDY
SIO_010081: YHL009W-B
subclass of: SO_0000673
so part of: YHL009W-B
location: join(85909..86994,86996..91318)
location: region:85909-91318:1
so has part: feature:85909-86994:1:exon
so has part: feature:86996-91318:1:exon

NP_058133.1
type: Protein
SIO_000068: ncbiprotein

S000007372
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85909-86994:1:exon

position:86994:1
position: 86994
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:86996-91318:1:exon

position:86996:1
position: 86996
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHL009W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL009W-A
so part of: sequence
location: <85909..>87150
location: region:85909-87150:1
so has part: feature:85909-87150:1:exon
subclass of: SO_0000010

856379
type: Gene
SIO_000068: ncbigene

position:87150:1
position: 87150
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85909-87150:1:exon

YHL009W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL009W-A
product: gag protein
transcript id: NM_001184403.1
SIO_010081: YHL009W-A
subclass of: SO_0000673
so part of: YHL009W-A
location: <85909..>87150
location: region:85909-87150:1
so has part: feature:85909-87150:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85909-87150:1:exon

YHL009W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL009W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MATPVRDETRNVIDDNISARIQSKVKTNDTVRQTPSSLRKVSIKDEQVKQYQRNLNRFKTILNGLKAEEEKLSETDDIQMLAEKLLKLGETIDKVENRIVDLVEKIQLLETNENNNILHEHIDATGTYYLFDTLTSTNKRFYPKDCVFDYRTNNVENIPILLNNFKKFIKKYQFDDVFENDIIEIDPRENEILCKIIKEGLGESLDIMNTNTTDIFRIIDGLKNKYRSLHGRDVRIRAWEKVLVDTTCRNSALLMNKLQKLVLMEKWIFSKCCQDCPNLKDYLQEAIMGTLHESLRNSVKQRLYNIPHNVGINHEEFLINTVIETVIDLSPIADDQIENSCMYCKSVFHCSINCKKKPNRELRPDSTNFSKTYYLQGAQRQQQLKSSAKRTKVLEQDTKKVKQSVQQQKTGNY
SIO_010081: YHL009W-A
subclass of: SO_0000673
so part of: YHL009W-A
location: 85909..87150
location: region:85909-87150:1
so has part: feature:85909-87150:1:exon

NP_058134.1
type: Protein
SIO_000068: ncbiprotein

S000007371
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85909-87150:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 91391..91761
location: region:91391-91761:1
so has part: feature:91391-91761:1:region

S000006990
type: SGD
SIO_000068: sgd

position:91391:1
position: 91391
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91391-91761:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(91772..92099)
location: region:91772-92099:-1
so has part: feature:91772-92099:-1:region

S000006985
type: SGD
SIO_000068: sgd

position:91772:-1
position: 91772
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:92099:-1
position: 92099
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91772-92099:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 92240..92390
location: region:92240-92390:1
so has part: feature:92240-92390:1:region

S000006988
type: SGD
SIO_000068: sgd

position:92240:1
position: 92240
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:92390:1
position: 92390
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92240-92390:1:region

YHL008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL008C
so part of: sequence
location: complement(<92627..>94510)
location: region:92627-94510:-1
so has part: feature:92627-94510:-1:exon
subclass of: SO_0000010

856381
type: Gene
SIO_000068: ncbigene

position:92627:-1
position: 92627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:94510:-1
position: 94510
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92627-94510:-1:exon

YHL008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL008C
product: uncharacterized protein
transcript id: NM_001179088.1
SIO_010081: YHL008C
subclass of: SO_0000673
so part of: YHL008C
location: complement(<92627..>94510)
location: region:92627-94510:-1
so has part: feature:92627-94510:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92627-94510:-1:exon

YHL008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL008C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006821 chloride transport [PMID:18378800]
experiment: EXISTENCE:mutant phenotype:GO:0140299 small molecule sensor activity [PMID:18378800]
experiment: EXISTENCE:mutant phenotype:GO:2001225 regulation of chloride transport [PMID:18378800]
note: hypothetical protein; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
codon start: 1
product: uncharacterized protein
translation: MVDDSNYLTPHETALAVVATAMKKARLQLDTLLINSILGGVLFSSGSFLLVAVYSEDPDIVARNPGIVNLITGVNFAMGLFYVVMMGADLFNSNILFFSVGVLRKAVTIYDLMISWVVSWLGNIAGSLFVSYLFGHLSGISSQKLWIIGSRQIIEQKVSYSFVQTFLKGIACNFFVCLAIYLQLMAKPIHVKFILMSFPIIDFIGIGFTHVVGDMSASFIAMLNGANVSVGKYIWKLLIPASLGNIVGGLFFSAVVPFYLHLVVVERDRKRLSLPEYEARDEQPELNMDSRVVRIQKNECDDDATETGEDLENLTEKGFASIYNTNHDNSSYFTGRSLNSLRSIPSSVITSDNVTMESDLGEPVQFIPKSNSTTRSPHLGLPHNLPHNHSIKSINRHRINKRHSLRSPPGVFPVRGMGEPLEREKTIEDATYDPKENELFLRRAETHNSAYVKNKKKEDDNLLRLVKTEEDREQKEYEKNGGYNILENKPGTRLEKIITHLAENVSSREVTPPILPRTTQDTFPHNAPASSPAYTDDAHSLRKANSTTLGGLFRAVSKEFHSSKDAESPDDLLKKMAAVGINRNARITANNVAGIVNLNKEDLDSTTRRQKITEPKNFYNRHTSPQL
SIO_010081: YHL008C
subclass of: SO_0000673
so part of: YHL008C
location: complement(92627..94510)
location: region:92627-94510:-1
so has part: feature:92627-94510:-1:exon

NP_011855.1
type: Protein
SIO_000068: ncbiprotein

S000001000
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92627-94510:-1:exon

YHL007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STE20
locus tag: YHL007C
so part of: sequence
location: complement(<95118..>97937)
location: region:95118-97937:-1
so has part: feature:95118-97937:-1:exon
subclass of: SO_0000010

856382
type: Gene
SIO_000068: ncbigene

position:95118:-1
position: 95118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97937:-1
position: 97937
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:95118-97937:-1:exon

YHL007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STE20
locus tag: YHL007C
product: mitogen-activated protein kinase kinase kinase kinase STE20
transcript id: NM_001179087.1
SIO_010081: YHL007C
subclass of: SO_0000673
so part of: YHL007C
location: complement(<95118..>97937)
location: region:95118-97937:-1
so has part: feature:95118-97937:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:95118-97937:-1:exon

YHL007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STE20
locus tag: YHL007C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9003780]
experiment: EXISTENCE:direct assay:GO:0000165 MAPK cascade [PMID:7608157]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19793923|PMID:15652479]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:7608157]
experiment: EXISTENCE:direct assay:GO:0008349 MAP kinase kinase kinase kinase activity [PMID:7608157]
experiment: EXISTENCE:direct assay:GO:0019899 enzyme binding [PMID:31395335]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9003780]
experiment: EXISTENCE:direct assay:GO:0044025 histone H2BS14 kinase activity [PMID:15652479]
experiment: EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:19218422]
experiment: EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:1464311]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:genetic interaction:GO:0007121 bipolar cellular bud site selection [PMID:10866679]
experiment: EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:10970855]
experiment: EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:genetic interaction:GO:0034063 stress granule assembly [PMID:20513766]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:19218422]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:1464311]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:8259520]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8259520]
experiment: EXISTENCE:mutant phenotype:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:10970855]
experiment: EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:20513766]
experiment: EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]
experiment: EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:15652479]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9428767]
note: Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family
codon start: 1
product: mitogen-activated protein kinase kinase kinase kinase STE20
translation: MSNDPSAVSELPDKDSLDNGISNDNERAMGGNGDGGDGLRLPRTTGTLNVNALQKGTNAAHEAGGYKSMDPAKNAETTNDDDNNVVSLDDPIQFTRVSSSSVISGMSSSMSPHSNIDETKSLEAVTPNINTSNITPDHSADNTFSTINASESDHQFNDTLLSKLSLTDSTETIENNATVKHQQPVASSTVNSNKSSTDIRRATPVSTPVISKPSMTTTPRQINSASHSLSNPKHKQHKPKVKPSKPEAKSKPVSVKKSFPSKNPLKNSSPPKKQTEKSYYSSSSKKRKSGSNSGTLRMKDVFTSFVQNIKRNSQDDKRASSSSNNSSSSSITTALRISTPYNAKHIHHVGVDSKTGEYTGLPEEWEKLLTSSGISKREQQQNMQAVMDIVKFYQDVTETNGEDKMFKTFNTTTGLPGSPQVSTPPANSFNKFPPSTSDSHNYGSRTGTPMSNHVMSPTLNTDSSSANGKFIPSRPAPKPPSSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNATLKKEEQPLPPIPPTKSKTSPIISTAHTPQQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREERERRKKQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVKLARLKKVAENMDADEDNDDDNDNEHINKTNNCDDNNDSKETVNLDVTEDDKQK
SIO_010081: YHL007C
subclass of: SO_0000673
so part of: YHL007C
location: complement(95118..97937)
location: region:95118-97937:-1
so has part: feature:95118-97937:-1:exon

NP_011856.1
type: Protein
SIO_000068: ncbiprotein

S000000999
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:95118-97937:-1:exon

YHL006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHU1
locus tag: YHL006C
so part of: sequence
location: complement(<98343..>98795)
location: region:98343-98795:-1
so has part: feature:98343-98795:-1:exon
subclass of: SO_0000010

856383
type: Gene
SIO_000068: ncbigene

position:98343:-1
position: 98343
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:98795:-1
position: 98795
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98343-98795:-1:exon

YHL006C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHU1
locus tag: YHL006C
product: Shu1p
transcript id: NM_001179086.1
SIO_010081: YHL006C
subclass of: SO_0000673
so part of: YHL006C
location: complement(<98343..>98795)
location: region:98343-98795:-1
so has part: feature:98343-98795:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98343-98795:-1:exon

YHL006C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHU1
locus tag: YHL006C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21372173]
experiment: EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]
experiment: EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]
experiment: EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:21372173]
experiment: EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]
experiment: EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]
experiment: EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]
experiment: EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]
note: Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments
codon start: 1
product: Shu1p
translation: MQFEERLQQLVESDWSLDQSSPNVLVIVLGDTARKYVELGGLKEHVTTNTVAGHVASRERVSVVFLGRVKYLYMYLTRMQAQANGPQYSNVLVYGLWDLTATQDGPQQLRLLSLVLRQCLSLPSKVEFYPEPPSSSVPARLLRFWDHIIR
SIO_010081: YHL006C
subclass of: SO_0000673
so part of: YHL006C
location: complement(98343..98795)
location: region:98343-98795:-1
so has part: feature:98343-98795:-1:exon

NP_011857.2
type: Protein
SIO_000068: ncbiprotein

S000000998
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98343-98795:-1:exon

YHL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHL005C
so part of: sequence
location: complement(<98828..>99220)
location: region:98828-99220:-1
so has part: feature:98828-99220:-1:exon
subclass of: SO_0000010

856385
type: Gene
SIO_000068: ncbigene

position:98828:-1
position: 98828
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99220:-1
position: 99220
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98828-99220:-1:exon

YHL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHL005C
product: uncharacterized protein
transcript id: NM_001348872.1
SIO_010081: YHL005C
subclass of: SO_0000673
so part of: YHL005C
location: complement(<98828..>99220)
location: region:98828-99220:-1
so has part: feature:98828-99220:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98828-99220:-1:exon

YHL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHL005C
note: hypothetical protein; conserved among S. cerevisiae strains; YHL005C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MRKESFLTFYFSNHLYLCPAIIRLSSVCTLARTDYYLPSNIAVTYDIQISSLGFTYRIDFFLALFSDPARPFLTEINRKIGQYACVIREREQAGEYSFHYSLCININVYILHIHIYIDRYIYAYINAQVQ
SIO_010081: YHL005C
subclass of: SO_0000673
so part of: YHL005C
location: complement(98828..99220)
location: region:98828-99220:-1
so has part: feature:98828-99220:-1:exon

NP_001335738.1
type: Protein
SIO_000068: ncbiprotein

S000000997
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98828-99220:-1:exon

YHL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uS2m
gene: MRP4
locus tag: YHL004W
gene synonym: uS2m
so part of: sequence
location: <99219..>100403
location: region:99219-100403:1
so has part: feature:99219-100403:1:exon
subclass of: SO_0000010

856384
type: Gene
SIO_000068: ncbigene

position:99219:1
position: 99219
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:100403:1
position: 100403
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99219-100403:1:exon

YHL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uS2m
gene: MRP4
locus tag: YHL004W
gene synonym: uS2m
product: mitochondrial 37S ribosomal protein MRP4
transcript id: NM_001179084.1
SIO_010081: YHL004W
subclass of: SO_0000673
so part of: YHL004W
location: <99219..>100403
location: region:99219-100403:1
so has part: feature:99219-100403:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:99219-100403:1:exon

YHL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uS2m
gene: MRP4
locus tag: YHL004W
gene synonym: uS2m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit
codon start: 1
product: mitochondrial 37S ribosomal protein MRP4
translation: MQRHVFARNFRRLSLLRNPSLTKRFQSSASGAANTPNNNDEVMLLQQKLLYDEIRSELKSLSQVPEDEILPELKKSLEQDKLSDKEQQLEAELSDFFRNYALLNKLFDSKTLDGQSSTTTAAATPTKPYPNLIPSANDKPYSSQELFLRQLNHSMRTAKLGATISKVYYPHKDIFYPPLPENITVESLMSAGVHLGQSTSLWRSSTQSYIYGEYKGIHIIDLNQTLSYLKRAAKVVEGVSESGGIILFLGTRQGQKRGLEEAAKKTHGYYVSTRWIPGTLTNSTEISGIWEKQEIDSNDNPTERALSPNETSKQVKPDLLVVLNPTENRNALLEAIKSRVPTIAIIDTDSEPSLVTYPIPGNDDSLRSVNFLLGVLARAGQRGLQNRLARNNEK
SIO_010081: YHL004W
subclass of: SO_0000673
so part of: YHL004W
location: 99219..100403
location: region:99219-100403:1
so has part: feature:99219-100403:1:exon

NP_011859.1
type: Protein
SIO_000068: ncbiprotein

S000000996
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:99219-100403:1:exon

YHL003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LAG1
locus tag: YHL003C
so part of: sequence
location: complement(<100648..>101883)
location: region:100648-101883:-1
so has part: feature:100648-101883:-1:exon
subclass of: SO_0000010

856386
type: Gene
SIO_000068: ncbigene

position:100648:-1
position: 100648
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:101883:-1
position: 101883
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100648-101883:-1:exon

YHL003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LAG1
locus tag: YHL003C
product: sphingosine N-acyltransferase LAG1
transcript id: NM_001179083.1
SIO_010081: YHL003C
subclass of: SO_0000673
so part of: YHL003C
location: complement(<100648..>101883)
location: region:100648-101883:-1
so has part: feature:100648-101883:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100648-101883:-1:exon

YHL003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LAG1
locus tag: YHL003C
EC number: 2.3.1.297
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276|PMID:14562095|PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0046513 ceramide biosynthetic process [PMID:15692566]
experiment: EXISTENCE:direct assay:GO:0050291 sphingosine N-acyltransferase activity [PMID:15692566]
experiment: EXISTENCE:direct assay:GO:0061576 acyl-CoA ceramide synthase complex [PMID:15692566]
experiment: EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:11694577]
experiment: EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:11387200|PMID:11694577]
note: Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication
codon start: 1
product: sphingosine N-acyltransferase LAG1
translation: MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE
SIO_010081: YHL003C
subclass of: SO_0000673
so part of: YHL003C
location: complement(100648..101883)
location: region:100648-101883:-1
so has part: feature:100648-101883:-1:exon

NP_011860.1
type: Protein
SIO_000068: ncbiprotein

S000000995
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100648-101883:-1:exon

YHL002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HSE1
locus tag: YHL002W
so part of: sequence
location: <102612..>103970
location: region:102612-103970:1
so has part: feature:102612-103970:1:exon
subclass of: SO_0000010

856387
type: Gene
SIO_000068: ncbigene

position:102612:1
position: 102612
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:103970:1
position: 103970
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102612-103970:1:exon

YHL002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HSE1
locus tag: YHL002W
product: ESCRT-0 subunit protein HSE1
transcript id: NM_001179082.1
SIO_010081: YHL002W
subclass of: SO_0000673
so part of: YHL002W
location: <102612..>103970
location: region:102612-103970:1
so has part: feature:102612-103970:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:102612-103970:1:exon

YHL002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HSE1
locus tag: YHL002W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:12055639]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:31740006]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12055639|PMID:20150893]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12055639]
experiment: EXISTENCE:mutant phenotype:GO:0016237 lysosomal microautophagy [PMID:31740006]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12055639]
experiment: EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]
experiment: EXISTENCE:physical interaction:GO:0006623 protein targeting to vacuole [PMID:12055639]
experiment: EXISTENCE:physical interaction:GO:0033565 ESCRT-0 complex [PMID:12055639]
note: Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
codon start: 1
product: ESCRT-0 subunit protein HSE1
translation: MSSSAIKIRNALLKATDPKLRSDNWQYILDVCDLVKEDPEDNGQEVMSLIEKRLEQQDANVILRTLSLTVSLAENCGSRLRQEISSKNFTSLLYALIESHSVHITLKKAVTDVVKQLSDSFKDDPSLRAMGDLYDKIKRKAPYLVQPNVPEKHNMSTQADNSDDEELQKALKMSLFEYEKQKKLQEQEKESAEVLPQQQQQHQQQNQAPAHKIPAQTVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIVEPSKEEIEKEKNKEAIVFSQKTTIDQLHNSLNAASKTGNSNEVLQDPHIGDMYGSVTPLRPQVTRMLGKYAKEKEDMLSLRQVLANAERSYNQLMDRAANAHISPPVPGPALYAGMTHANNTPVMPPQRQSYQSNEYSPYPSNLPIQHPTNSANNTPQYGYDLGYSVVSQPPPGYEQ
SIO_010081: YHL002W
subclass of: SO_0000673
so part of: YHL002W
location: 102612..103970
location: region:102612-103970:1
so has part: feature:102612-103970:1:exon

NP_011861.1
type: Protein
SIO_000068: ncbiprotein

S000000994
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:102612-103970:1:exon

YHL001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL14B
locus tag: YHL001W
so part of: sequence
location: <104277..>105091
location: region:104277-105091:1
so has part: feature:104277-105091:1:exon
subclass of: SO_0000010

856388
type: Gene
SIO_000068: ncbigene

position:104277:1
position: 104277
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:105091:1
position: 105091
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:104277-105091:1:exon

YHL001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL14B
locus tag: YHL001W
product: ribosomal 60S subunit protein L14B
transcript id: NM_001179081.1
SIO_010081: YHL001W
subclass of: SO_0000673
so part of: YHL001W
location: join(<104277..104405,104804..>105091)
location: region:104277-105091:1
so has part: feature:104277-104405:1:exon
so has part: feature:104804-105091:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:104277-104405:1:exon

position:104405:1
position: 104405
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:104804-105091:1:exon

position:104804:1
position: 104804
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHL001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL14B
locus tag: YHL001W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:29788267]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:29788267]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:29788267]
note: Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
codon start: 1
product: ribosomal 60S subunit protein L14B
translation: MSTDSIVKASNWRLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKAGVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAGVCEKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKRYTVKKALAKA
SIO_010081: YHL001W
subclass of: SO_0000673
so part of: YHL001W
location: join(104277..104405,104804..105091)
location: region:104277-105091:1
so has part: feature:104277-104405:1:exon
so has part: feature:104804-105091:1:exon

NP_011862.1
type: Protein
SIO_000068: ncbiprotein

S000000993
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:104277-104405:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:104804-105091:1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN8; Chromosome VIII centromere
so part of: sequence
location: complement(105586..105703)
location: region:105586-105703:-1
so has part: feature:105586-105703:-1:region

S000006469
type: SGD
SIO_000068: sgd

position:105586:-1
position: 105586
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:105703:-1
position: 105703
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105586-105703:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN8_CDEIII of CEN8
so part of: sequence
location: complement(105586..105610)
location: region:105586-105610:-1
so has part: feature:105586-105610:-1:region

position:105610:-1
position: 105610
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105586-105610:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN8_CDEII of CEN8
so part of: sequence
location: complement(105611..105693)
location: region:105611-105693:-1
so has part: feature:105611-105693:-1:region

position:105611:-1
position: 105611
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:105693:-1
position: 105693
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105611-105693:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN8_CDEI of CEN8
so part of: sequence
location: complement(105694..105703)
location: region:105694-105703:-1
so has part: feature:105694-105703:-1:region

position:105694:-1
position: 105694
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:105694-105703:-1:region

YHR001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSH7
locus tag: YHR001W
so part of: sequence
location: <106055..>107368
location: region:106055-107368:1
so has part: feature:106055-107368:1:exon
subclass of: SO_0000010

856389
type: Gene
SIO_000068: ncbigene

position:106055:1
position: 106055
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:107368:1
position: 107368
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:106055-107368:1:exon

YHR001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSH7
locus tag: YHR001W
product: oxysterol-binding protein related protein OSH7
transcript id: NM_001179131.1
SIO_010081: YHR001W
subclass of: SO_0000673
so part of: YHR001W
location: <106055..>107368
location: region:106055-107368:1
so has part: feature:106055-107368:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:106055-107368:1:exon

YHR001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSH7
locus tag: YHR001W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16096648]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29487131]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]
experiment: EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]
experiment: EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]
experiment: EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]
experiment: EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:16096648]
note: Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication
codon start: 1
product: oxysterol-binding protein related protein OSH7
translation: MALNKLKNIPSLTNSSHSSINGIASNAANSKPSGADTDDIDENDESGQSILLNIISQLKPGCDLSRITLPTFILEKKSMLERITNQLQFPDVLLEAHSNKDGLQRFVKVVAWYLAGWHIGPRAVKKPLNPILGEHFTAYWDLPNKQQAFYIAEQTSHHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYTLSQPNVYARGILFGKMRIELGDHMVIMGPKYQVDIEFKTKGFISGTYDAIEGTIKDYDGKEYYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFPLAPKVRPLEEQGEYESRRLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAEPGEDLDYYIYKHIPEGTDKHEEQIRSILETAPILPGQTFTEKFSIPAYKKHGIQKN
SIO_010081: YHR001W
subclass of: SO_0000673
so part of: YHR001W
location: 106055..107368
location: region:106055-107368:1
so has part: feature:106055-107368:1:exon

NP_011863.1
type: Protein
SIO_000068: ncbiprotein

S000001043
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:106055-107368:1:exon

YHR001W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: QCR10
locus tag: YHR001W-A
so part of: sequence
location: <107826..>108122
location: region:107826-108122:1
so has part: feature:107826-108122:1:exon
subclass of: SO_0000010

856390
type: Gene
SIO_000068: ncbigene

position:107826:1
position: 107826
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:108122:1
position: 108122
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:107826-108122:1:exon

YHR001W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: QCR10
locus tag: YHR001W-A
product: ubiquinol--cytochrome-c reductase subunit 10
transcript id: NM_001181426.1
SIO_010081: YHR001W-A
subclass of: SO_0000673
so part of: YHR001W-A
location: join(<107826..107831,107895..>108122)
location: region:107826-108122:1
so has part: feature:107826-107831:1:exon
so has part: feature:107895-108122:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:107826-107831:1:exon

position:107831:1
position: 107831
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:107895-108122:1:exon

position:107895:1
position: 107895
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR001W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: QCR10
locus tag: YHR001W-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005750 mitochondrial respiratory chain complex III [PMID:8175712]
experiment: EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:8175712]
experiment: EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:8175712]
experiment: EXISTENCE:mutant phenotype:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:8175712]
note: Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
codon start: 1
product: ubiquinol--cytochrome-c reductase subunit 10
translation: MAYTSHLSSKTGLHFGRLSLRSLTAYAPNLMLWGGASMLGLFVFTEGWPKFQDTLYKKIPLLGPTLEDHTPPEDKPN
SIO_010081: YHR001W-A
subclass of: SO_0000673
so part of: YHR001W-A
location: join(107826..107831,107895..108122)
location: region:107826-108122:1
so has part: feature:107826-107831:1:exon
so has part: feature:107895-108122:1:exon

NP_011864.1
type: Protein
SIO_000068: ncbiprotein

S000003529
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:107826-107831:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:107895-108122:1:exon

YHR002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LEU5
locus tag: YHR002W
so part of: sequence
location: <108812..>109885
location: region:108812-109885:1
so has part: feature:108812-109885:1:exon
subclass of: SO_0000010

856391
type: Gene
SIO_000068: ncbigene

position:108812:1
position: 108812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:109885:1
position: 109885
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108812-109885:1:exon

YHR002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LEU5
locus tag: YHR002W
product: coenzyme A transporter
transcript id: NM_001179132.1
SIO_010081: YHR002W
subclass of: SO_0000673
so part of: YHR002W
location: <108812..>109885
location: region:108812-109885:1
so has part: feature:108812-109885:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108812-109885:1:exon

YHR002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LEU5
locus tag: YHR002W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11158296]
experiment: EXISTENCE:mutant phenotype:GO:0015228 coenzyme A transmembrane transporter activity [PMID:11158296]
experiment: EXISTENCE:mutant phenotype:GO:0015880 coenzyme A transport [PMID:11158296]
note: Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized
codon start: 1
product: coenzyme A transporter
translation: MTRDSPDSNDSYKHINKNTTQKTSFDRNSFDYIVRSGLAGGISGSCAKTLIAPLDRIKILFQTSNPHYTKYTGSLIGLVEAAKHIWINDGVRGFFQGHSATLLRIFPYAAVKFVAYEQIRNTLIPSKEFESHWRRLVSGSLAGLCSVFITYPLDLVRVRLAYETEHKRVKLGRIIKKIYKEPASATLIKNDYIPNWFCHWCNFYRGYVPTVLGMIPYAGVSFFAHDLLHDVLKSPFFAPYSVLELSEDDELERVQKKQRRPLRTWAELISGGLAGMASQTAAYPFEIIRRRLQVSALSPKTMYDHKFQSISEIAHIIFKERGVRGFFVGLSIGYIKVTPMVACSFFVYERMKWNFGI
SIO_010081: YHR002W
subclass of: SO_0000673
so part of: YHR002W
location: 108812..109885
location: region:108812-109885:1
so has part: feature:108812-109885:1:exon

NP_011865.1
type: Protein
SIO_000068: ncbiprotein

S000001044
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108812-109885:1:exon

YHR003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCD1
locus tag: YHR003C
so part of: sequence
location: complement(<110028..>111317)
location: region:110028-111317:-1
so has part: feature:110028-111317:-1:exon
subclass of: SO_0000010

856392
type: Gene
SIO_000068: ncbigene

position:110028:-1
position: 110028
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:111317:-1
position: 111317
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110028-111317:-1:exon

YHR003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCD1
locus tag: YHR003C
product: tRNA threonylcarbamoyladenosine dehydratase
transcript id: NM_001179133.1
SIO_010081: YHR003C
subclass of: SO_0000673
so part of: YHR003C
location: complement(<110028..>111317)
location: region:110028-111317:-1
so has part: feature:110028-111317:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:110028-111317:-1:exon

YHR003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCD1
locus tag: YHR003C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:mutant phenotype:GO:0061503 tRNA threonylcarbamoyladenosine dehydratase [PMID:23242255]
experiment: EXISTENCE:mutant phenotype:GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process [PMID:23242255]
note: tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication
codon start: 1
product: tRNA threonylcarbamoyladenosine dehydratase
translation: MANNTWKLIATTALISVFSTQLAKSVWKEYKLSCAANKNKTVSRPRQYDDHLFREQLARNYAFLGEEGMRKIKEQYIVIVGAGEVGSWVCTMLIRSGCQKIMIIDPENISIDSLNTHCCAVLSDIGKPKVQCLKEHLSKIAPWSEIKARAKAWTKENSHDLIFADGESPTFIVDCLDNLESKVDLLEYAHHNKIDVISSMGVATKSDPTRVSINDISMTEFDPISRCVRRKLRKRGIATGISVVFSNEMLDPRRDDILSPIDCEHRAINAVRDEALRHLPELGTMPGIFGLSIATWILTKVSGYPMKENEVKNRLKFYDSILETFQKQMARLNENKERSSLLGLEEVGYIVEEMFRGKSPISGYSTKLALTKWEANKEISLTNVVLMTKEEQEIHEKRILLDGEKLTAVYSEEVLDFIERLFKEEEYYS
SIO_010081: YHR003C
subclass of: SO_0000673
so part of: YHR003C
location: complement(110028..111317)
location: region:110028-111317:-1
so has part: feature:110028-111317:-1:exon

NP_011866.1
type: Protein
SIO_000068: ncbiprotein

S000001045
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110028-111317:-1:exon

YHR004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NEM1
locus tag: YHR004C
so part of: sequence
location: complement(<111754..>113094)
location: region:111754-113094:-1
so has part: feature:111754-113094:-1:exon
subclass of: SO_0000010

856393
type: Gene
SIO_000068: ncbigene

position:111754:-1
position: 111754
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:113094:-1
position: 113094
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111754-113094:-1:exon

YHR004C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NEM1
locus tag: YHR004C
product: Nem1-Spo7 phosphatase catalytic subunit NEM1
transcript id: NM_001179134.1
SIO_010081: YHR004C
subclass of: SO_0000673
so part of: YHR004C
location: complement(<111754..>113094)
location: region:111754-113094:-1
so has part: feature:111754-113094:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111754-113094:-1:exon

YHR004C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NEM1
locus tag: YHR004C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:15889145|PMID:25359770]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:32349126]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:26275961]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:9822591]
experiment: EXISTENCE:direct assay:GO:1903740 positive regulation of phosphatidate phosphatase activity [PMID:25359770]
experiment: EXISTENCE:genetic interaction:GO:0071072 negative regulation of phospholipid biosynthetic process [PMID:15889145]
experiment: EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:9822591]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:32349126]
experiment: EXISTENCE:mutant phenotype:GO:0046889 positive regulation of lipid biosynthetic process [PMID:32349126]
experiment: EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:30201607]
experiment: EXISTENCE:mutant phenotype:GO:0140042 lipid droplet formation [PMID:32349126]
experiment: EXISTENCE:physical interaction:GO:0071595 Nem1-Spo7 phosphatase complex [PMID:9822591]
note: Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology and sporulation; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; homolog of the human protein Dullard
codon start: 1
product: Nem1-Spo7 phosphatase catalytic subunit NEM1
translation: MNALKYFSNHLITTKKQKKINVEVTKNQDLLGPSKEVSNKYTSHSENDCVSEVDQQYDHSSSHLKESDQNQERKNSVPKKPKALRSILIEKIASILWALLLFLPYYLIIKPLMSLWFVFTFPLSVIERRVKHTDKRNRGSNASENELPVSSSNINDSSEKTNPKNCNLNTIPEAVEDDLNASDEIILQRDNVKGSLLRAQSVKSRPRSYSKSELSLSNHSSSNTVFGTKRMGRFLFPKKLIPKSVLNTQKKKKLVIDLDETLIHSASRSTTHSNSSQGHLVEVKFGLSGIRTLYFIHKRPYCDLFLTKVSKWYDLIIFTASMKEYADPVIDWLESSFPSSFSKRYYRSDCVLRDGVGYIKDLSIVKDSEENGKGSSSSLDDVIIIDNSPVSYAMNVDNAIQVEGWISDPTDTDLLNLLPFLEAMRYSTDVRNILALKHGEKAFNIN
SIO_010081: YHR004C
subclass of: SO_0000673
so part of: YHR004C
location: complement(111754..113094)
location: region:111754-113094:-1
so has part: feature:111754-113094:-1:exon

NP_011867.1
type: Protein
SIO_000068: ncbiprotein

S000001046
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111754-113094:-1:exon

YHR005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC70
alternative label: DAC1
alternative label: SCG1
gene: GPA1
locus tag: YHR005C
gene synonym: CDC70; DAC1; SCG1
so part of: sequence
location: complement(<113499..>114917)
location: region:113499-114917:-1
so has part: feature:113499-114917:-1:exon
subclass of: SO_0000010

856394
type: Gene
SIO_000068: ncbigene

position:113499:-1
position: 113499
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:114917:-1
position: 114917
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:113499-114917:-1:exon

YHR005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC70
alternative label: DAC1
alternative label: SCG1
gene: GPA1
locus tag: YHR005C
gene synonym: CDC70; DAC1; SCG1
product: guanine nucleotide-binding protein subunit alpha
transcript id: NM_001179135.1
SIO_010081: YHR005C
subclass of: SO_0000673
so part of: YHR005C
location: complement(<113499..>114917)
location: region:113499-114917:-1
so has part: feature:113499-114917:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:113499-114917:-1:exon

YHR005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC70
alternative label: DAC1
alternative label: SCG1
gene: GPA1
locus tag: YHR005C
gene synonym: CDC70; DAC1; SCG1
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11394869]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:16839886]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005834 heterotrimeric G-protein complex [PMID:11394869]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8756677]
experiment: EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]
experiment: EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:19386762]
experiment: EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:19386762]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3113739]
experiment: EXISTENCE:mutant phenotype:GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [PMID:12556475|PMID:2105453]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:1900495]
experiment: EXISTENCE:mutant phenotype:GO:0005834 heterotrimeric G-protein complex [PMID:2105453]
experiment: EXISTENCE:mutant phenotype:GO:0006109 regulation of carbohydrate metabolic process [PMID:34214075]
experiment: EXISTENCE:mutant phenotype:GO:0048017 inositol lipid-mediated signaling [PMID:16839886]
experiment: EXISTENCE:mutant phenotype:GO:0071701 regulation of MAPK export from nucleus [PMID:12556475]
experiment: EXISTENCE:physical interaction:GO:0005834 heterotrimeric G-protein complex [PMID:11394869]
experiment: EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:8417317]
note: Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome
codon start: 1
product: guanine nucleotide-binding protein subunit alpha
translation: MGCTVSTQTIGDESDPFLQNKRANDVIEQSLQLEKQRDKNEIKLLLLGAGESGKSTVLKQLKLLHQGGFSHQERLQYAQVIWADAIQSMKILIIQARKLGIQLDCDDPINNKDLFACKRILLKAKALDYINASVAGGSDFLNDYVLKYSERYETRRRVQSTGRAKAAFDEDGNISNVKSDTDRDAETVTQNEDADRNNSSRINLQDICKDLNQEGDDQMFVRKTSREIQGQNRRNLIHEDIAKAIKQLWNNDKGIKQCFARSNEFQLEGSAAYYFDNIEKFASPNYVCTDEDILKGRIKTTGITETEFNIGSSKFKVLDAGGQRSERKKWIHCFEGITAVLFVLAMSEYDQMLFEDERVNRMHESIMLFDTLLNSKWFKDTPFILFLNKIDLFEEKVKSMPIRKYFPDYQGRVGDAEAGLKYFEKIFLSLNKTNKPIYVKRTCATDTQTMKFVLSAVTDLIIQQNLKKIGII
SIO_010081: YHR005C
subclass of: SO_0000673
so part of: YHR005C
location: complement(113499..114917)
location: region:113499-114917:-1
so has part: feature:113499-114917:-1:exon

NP_011868.1
type: Protein
SIO_000068: ncbiprotein

S000001047
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:113499-114917:-1:exon

YHR005C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MRS11
gene: TIM10
locus tag: YHR005C-A
gene synonym: MRS11
so part of: sequence
location: complement(<115620..>115901)
location: region:115620-115901:-1
so has part: feature:115620-115901:-1:exon
subclass of: SO_0000010

856395
type: Gene
SIO_000068: ncbigene

position:115620:-1
position: 115620
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:115901:-1
position: 115901
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:115620-115901:-1:exon

YHR005C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MRS11
gene: TIM10
locus tag: YHR005C-A
gene synonym: MRS11
product: protein transporter TIM10
transcript id: NM_001181427.1
SIO_010081: YHR005C-A
subclass of: SO_0000673
so part of: YHR005C-A
location: complement(<115620..>115901)
location: region:115620-115901:-1
so has part: feature:115620-115901:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:115620-115901:-1:exon

YHR005C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MRS11
gene: TIM10
locus tag: YHR005C-A
gene synonym: MRS11
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:9889188|PMID:9822593]
experiment: EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9495346]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12138093]
experiment: EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:9495346]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9430585]
experiment: EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9430585]
note: Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
codon start: 1
product: protein transporter TIM10
translation: MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
SIO_010081: YHR005C-A
subclass of: SO_0000673
so part of: YHR005C-A
location: complement(115620..115901)
location: region:115620-115901:-1
so has part: feature:115620-115901:-1:exon

NP_011869.1
type: Protein
SIO_000068: ncbiprotein

S000003530
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:115620-115901:-1:exon

YNCH0003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0003C
so part of: sequence
location: complement(116107..116179)
location: region:116107-116179:-1
so has part: feature:116107-116179:-1:exon
subclass of: SO_0000663

856396
type: Gene
SIO_000068: ncbigene

position:116107:-1
position: 116107
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:116179:-1
position: 116179
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116107-116179:-1:exon

YNCH0003C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0003C
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0003C
subclass of: SO_0000673
so part of: YNCH0003C
location: complement(116107..116179)
location: region:116107-116179:-1
so has part: feature:116107-116179:-1:exon

S000006740
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116107-116179:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS806; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 116179..116421
location: region:116179-116421:1
so has part: feature:116179-116421:1:region

S000130146
type: SGD
SIO_000068: sgd

position:116179:1
position: 116179
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:116421:1
position: 116421
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116179-116421:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(116421..116752)
location: region:116421-116752:-1
so has part: feature:116421-116752:-1:region

S000006992
type: SGD
SIO_000068: sgd

position:116421:-1
position: 116421
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:116752:-1
position: 116752
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116421-116752:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(116763..117061)
location: region:116763-117061:-1
so has part: feature:116763-117061:-1:region

S000006993
type: SGD
SIO_000068: sgd

position:116763:-1
position: 116763
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:117061:-1
position: 117061
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116763-117061:-1:region

YHR006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STP2
locus tag: YHR006W
so part of: sequence
location: <117814..>119439
location: region:117814-119439:1
so has part: feature:117814-119439:1:exon
subclass of: SO_0000010

856397
type: Gene
SIO_000068: ncbigene

position:117814:1
position: 117814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:119439:1
position: 119439
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117814-119439:1:exon

YHR006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STP2
locus tag: YHR006W
product: Stp2p
transcript id: NM_001179136.1
SIO_010081: YHR006W
subclass of: SO_0000673
so part of: YHR006W
location: <117814..>119439
location: region:117814-119439:1
so has part: feature:117814-119439:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:117814-119439:1:exon

YHR006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STP2
locus tag: YHR006W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11212916]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10648791|PMID:19906648]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21127045]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21127045]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10648791|PMID:19906648]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10648791]
note: Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
codon start: 1
product: Stp2p
translation: MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF
SIO_010081: YHR006W
subclass of: SO_0000673
so part of: YHR006W
location: 117814..119439
location: region:117814-119439:1
so has part: feature:117814-119439:1:exon

NP_011870.1
type: Protein
SIO_000068: ncbiprotein

S000001048
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117814-119439:1:exon

YHR007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP51
gene: ERG11
locus tag: YHR007C
gene synonym: CYP51
so part of: sequence
location: complement(<120091..>121683)
location: region:120091-121683:-1
so has part: feature:120091-121683:-1:exon
subclass of: SO_0000010

856398
type: Gene
SIO_000068: ncbigene

position:120091:-1
position: 120091
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121683:-1
position: 121683
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:120091-121683:-1:exon

YHR007C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP51
gene: ERG11
locus tag: YHR007C
gene synonym: CYP51
product: sterol 14-demethylase
transcript id: NM_001179137.1
SIO_010081: YHR007C
subclass of: SO_0000673
so part of: YHR007C
location: complement(<120091..>121683)
location: region:120091-121683:-1
so has part: feature:120091-121683:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:120091-121683:-1:exon

YHR007C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP51
gene: ERG11
locus tag: YHR007C
gene synonym: CYP51
EC number: 1.14.14.154
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15951236|PMID:26928762|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:105731]
experiment: EXISTENCE:direct assay:GO:0008398 sterol 14-demethylase activity [PMID:9087488|PMID:105731]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]
note: Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation
codon start: 1
product: sterol 14-demethylase
translation: MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI
SIO_010081: YHR007C
subclass of: SO_0000673
so part of: YHR007C
location: complement(120091..121683)
location: region:120091-121683:-1
so has part: feature:120091-121683:-1:exon

NP_011871.1
type: Protein
SIO_000068: ncbiprotein

S000001049
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:120091-121683:-1:exon

YHR007C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR007C-A
so part of: sequence
location: complement(<122550..>122765)
location: region:122550-122765:-1
so has part: feature:122550-122765:-1:exon
subclass of: SO_0000010

1466526
type: Gene
SIO_000068: ncbigene

position:122550:-1
position: 122550
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:122765:-1
position: 122765
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122550-122765:-1:exon

YHR007C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR007C-A
product: uncharacterized protein
transcript id: NM_001184651.1
SIO_010081: YHR007C-A
subclass of: SO_0000673
so part of: YHR007C-A
location: complement(<122550..>122765)
location: region:122550-122765:-1
so has part: feature:122550-122765:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122550-122765:-1:exon

YHR007C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR007C-A
note: hypothetical protein; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus
codon start: 1
product: uncharacterized protein
translation: MHRKKRKKEKKRTEKDNTTNLPPLFLFPCSLSLPTLLAPVHYIPTRLTHHQAENQLFLLLFQPIIVKPLRS
SIO_010081: YHR007C-A
subclass of: SO_0000673
so part of: YHR007C-A
location: complement(122550..122765)
location: region:122550-122765:-1
so has part: feature:122550-122765:-1:exon

NP_878086.1
type: Protein
SIO_000068: ncbiprotein

S000028830
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122550-122765:-1:exon

YHR008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOD2
locus tag: YHR008C
so part of: sequence
location: complement(<122889..>123590)
location: region:122889-123590:-1
so has part: feature:122889-123590:-1:exon
subclass of: SO_0000010

856399
type: Gene
SIO_000068: ncbigene

position:122889:-1
position: 122889
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:123590:-1
position: 123590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122889-123590:-1:exon

YHR008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOD2
locus tag: YHR008C
product: superoxide dismutase SOD2
transcript id: NM_001179138.1
SIO_010081: YHR008C
subclass of: SO_0000673
so part of: YHR008C
location: complement(<122889..>123590)
location: region:122889-123590:-1
so has part: feature:122889-123590:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122889-123590:-1:exon

YHR008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOD2
locus tag: YHR008C
EC number: 1.15.1.1
experiment: EXISTENCE:direct assay:GO:0004784 superoxide dismutase activity [PMID:15851472|PMID:238997]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15851472|PMID:14576278|PMID:11914276|PMID:16823961|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:238997]
experiment: EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:3520557]
note: Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix
codon start: 1
product: superoxide dismutase SOD2
translation: MFAKTAAANLTKKGGLSLLSTTARRTKVTLPDLKWDFGALEPYISGQINELHYTKHHQTYVNGFNTAVDQFQELSDLLAKEPSPANARKMIAIQQNIKFHGGGFTNHCLFWENLAPESQGGGEPPTGALAKAIDEQFGSLDELIKLTNTKLAGVQGSGWAFIVKNLSNGGKLDVVQTYNQDTVTGPLVPLVAIDAWEHAYYLQYQNKKADYFKAIWNVVNWKEASRRFDAGKI
SIO_010081: YHR008C
subclass of: SO_0000673
so part of: YHR008C
location: complement(122889..123590)
location: region:122889-123590:-1
so has part: feature:122889-123590:-1:exon

NP_011872.1
type: Protein
SIO_000068: ncbiprotein

S000001050
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122889-123590:-1:exon

YHR009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BTN3
gene: TDA3
locus tag: YHR009C
gene synonym: BTN3
so part of: sequence
location: complement(<124109..>125680)
location: region:124109-125680:-1
so has part: feature:124109-125680:-1:exon
subclass of: SO_0000010

856400
type: Gene
SIO_000068: ncbigene

position:124109:-1
position: 124109
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:125680:-1
position: 125680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:124109-125680:-1:exon

YHR009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BTN3
gene: TDA3
locus tag: YHR009C
gene synonym: BTN3
product: Tda3p
transcript id: NM_001179139.1
SIO_010081: YHR009C
subclass of: SO_0000673
so part of: YHR009C
location: complement(<124109..>125680)
location: region:124109-125680:-1
so has part: feature:124109-125680:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124109-125680:-1:exon

YHR009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BTN3
gene: TDA3
locus tag: YHR009C
gene synonym: BTN3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21441304|PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:21441304]
experiment: EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]
experiment: EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]
note: Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1
codon start: 1
product: Tda3p
translation: MGEDFMHPPFQTYPSKNSEGKKHIVIVGGGIIGCCTAYYLTQHPSFSPSTHHITIIESRRIAGGASGKAGGLLASWAFPHQIVPLSFQLHQELSDEYDGENNWDYRRLTTVSLEADVREEVIENYERLSKKAYNLNVPPPKKRPGYISNKFNIGDSNSSLSSSGSSLKNDSASNEEEGSDIHVSSSVPSLHSLTNERMRSHTNSASDLDSVSPVEQLRETNIHNPLPADLDWIRRELVNDWSSLGGTDTTAQLHPYKFTHFILSKAMETGAVDLLLGKVVGLKCDEMDCVHSLKYLPSVVKNRRNSRGHAENPDIKLGTIFNDENAKPIEINDIQQIVLSMGPWTSKILKDCPISGLRAHSVTIKPSEKTVSPYAILAELKVNDREFFSPEMYARKDEVYVCGEGDTLVNIPESSDDVEVVSEKCDELYHYVSKLSPTLSKGHLLRKQACFLPVLNVPTSSGPLIGETNVKDLYIASGHSCWGINNAPATGKLMAEILLDGEATSAEISSLDPKLYFDATILS
SIO_010081: YHR009C
subclass of: SO_0000673
so part of: YHR009C
location: complement(124109..125680)
location: region:124109-125680:-1
so has part: feature:124109-125680:-1:exon

NP_011873.1
type: Protein
SIO_000068: ncbiprotein

S000001051
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124109-125680:-1:exon

YHR010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL27
gene: RPL27A
locus tag: YHR010W
gene synonym: RPL27
so part of: sequence
location: <126521..>127492
location: region:126521-127492:1
so has part: feature:126521-127492:1:exon
subclass of: SO_0000010

856401
type: Gene
SIO_000068: ncbigene

position:126521:1
position: 126521
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:127492:1
position: 127492
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126521-127492:1:exon

YHR010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL27
gene: RPL27A
locus tag: YHR010W
gene synonym: RPL27
product: ribosomal 60S subunit protein L27A
transcript id: NM_001179140.1
SIO_010081: YHR010W
subclass of: SO_0000673
so part of: YHR010W
location: join(<126521..126551,127113..>127492)
location: region:126521-127492:1
so has part: feature:126521-126551:1:exon
so has part: feature:127113-127492:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:126521-126551:1:exon

position:126551:1
position: 126551
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:127113-127492:1:exon

position:127113:1
position: 127113
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL27
gene: RPL27A
locus tag: YHR010W
gene synonym: RPL27
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L27A
translation: MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHALVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKVVNYNHLLPTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEERHQAGKNQWFFSKLRF
SIO_010081: YHR010W
subclass of: SO_0000673
so part of: YHR010W
location: join(126521..126551,127113..127492)
location: region:126521-127492:1
so has part: feature:126521-126551:1:exon
so has part: feature:127113-127492:1:exon

NP_011874.1
type: Protein
SIO_000068: ncbiprotein

S000001052
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:126521-126551:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:127113-127492:1:exon

YHR011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DIA4
locus tag: YHR011W
so part of: sequence
location: <127780..>129120
location: region:127780-129120:1
so has part: feature:127780-129120:1:exon
subclass of: SO_0000010

856402
type: Gene
SIO_000068: ncbigene

position:127780:1
position: 127780
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:129120:1
position: 129120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:127780-129120:1:exon

YHR011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DIA4
locus tag: YHR011W
product: putative serine--tRNA ligase DIA4
transcript id: NM_001179141.1
SIO_010081: YHR011W
subclass of: SO_0000673
so part of: YHR011W
location: <127780..>129120
location: region:127780-129120:1
so has part: feature:127780-129120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:127780-129120:1:exon

YHR011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DIA4
locus tag: YHR011W
EC number: 6.1.1.11
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0004828 serine-tRNA ligase activity [PMID:11747308]
experiment: EXISTENCE:genetic interaction:GO:0070158 mitochondrial seryl-tRNA aminoacylation [PMID:11747308]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:11747308]
note: Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth
codon start: 1
product: putative serine--tRNA ligase DIA4
translation: MIIRRLFSISNRSFFLKKPQFDVKKIIEMIPQYQTSIQNRELIEADSIIRSLQLLGERYQNIKEIDKVIADIQIQRKSIEAQIKKDKTKITEYSAALKALKEQYNDQNSKSSELKKKILETCKSLPNTLDPTVPLDAPQIEQWINPLKTHKTSEAQAHVDIMLKKNMLDLQTASNVTGMSWYYLLNDGARLEQALVAYALKKANENGFSSCVPPSITKKELIDACGFNPRDMNNERQIYALQDTNLGLVATAEIPLAGLGANKVLELNSGECSKKLVGVSRCYRAEAGARGKDTKGLYRVHEFTKVELFCWSKPETSAKVLEEIKQFQISVVEELGIPAKVLNMPSNDLGNPAFKKYDIEAWMPGRGKFGEISSASNCTDFQSRRLNTKYRDDNTGKLEYVHTLNGTAMAIPRVIVALVENFYDPSTGKISVPECLREFMNGQRYI
SIO_010081: YHR011W
subclass of: SO_0000673
so part of: YHR011W
location: 127780..129120
location: region:127780-129120:1
so has part: feature:127780-129120:1:exon

NP_011875.1
type: Protein
SIO_000068: ncbiprotein

S000001053
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:127780-129120:1:exon

YHR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PEP11
alternative label: VPT6
gene: VPS29
locus tag: YHR012W
gene synonym: PEP11; VPT6
so part of: sequence
location: <129481..>130448
location: region:129481-130448:1
so has part: feature:129481-130448:1:exon
subclass of: SO_0000010

856403
type: Gene
SIO_000068: ncbigene

position:129481:1
position: 129481
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130448:1
position: 130448
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129481-130448:1:exon

YHR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PEP11
alternative label: VPT6
gene: VPS29
locus tag: YHR012W
gene synonym: PEP11; VPT6
product: retromer subunit VPS29
transcript id: NM_001179142.1
SIO_010081: YHR012W
subclass of: SO_0000673
so part of: YHR012W
location: join(<129481..129528,129648..>130448)
location: region:129481-130448:1
so has part: feature:129481-129528:1:exon
so has part: feature:129648-130448:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129481-129528:1:exon

position:129528:1
position: 129528
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:129648-130448:1:exon

position:129648:1
position: 129648
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PEP11
alternative label: VPT6
gene: VPS29
locus tag: YHR012W
gene synonym: PEP11; VPT6
experiment: EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0030906 retromer, cargo-selective complex [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]
experiment: EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]
note: Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
codon start: 1
product: retromer subunit VPS29
translation: MLLLALSDAHIPDRATDLPVKFKKLLSVPDKISQVALLGNSTKSYDFLKFVNQISNNITIVRGEFDNGHLPSTKKDKASDNSRPMEEIPMNSIIRQGALKIGCCSGYTVVPKNDPLSLLALARQLDVDILLWGGTHNVEAYTLEGKFFVNPGSCTGAFNTDWPIVFDVEDSDEAVTSEVDKPTKENQSEDDDAKGGSTGKEQPGSYTPKEGTAGERENENESNVKPENQFKEDEVDMSDSDINGSNSPSFCLLDIQGNTCTLYIYLYVNGEVKVDKVVYEKE
SIO_010081: YHR012W
subclass of: SO_0000673
so part of: YHR012W
location: join(129481..129528,129648..130448)
location: region:129481-130448:1
so has part: feature:129481-129528:1:exon
so has part: feature:129648-130448:1:exon

NP_011876.1
type: Protein
SIO_000068: ncbiprotein

S000001054
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129481-129528:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:129648-130448:1:exon

YHR013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAA10
gene: ARD1
locus tag: YHR013C
gene synonym: NAA10
so part of: sequence
location: complement(<130730..>131446)
location: region:130730-131446:-1
so has part: feature:130730-131446:-1:exon
subclass of: SO_0000010

856404
type: Gene
SIO_000068: ncbigene

position:130730:-1
position: 130730
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131446:-1
position: 131446
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:130730-131446:-1:exon

YHR013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAA10
gene: ARD1
locus tag: YHR013C
gene synonym: NAA10
product: peptide alpha-N-acetyltransferase complex A subunit ARD1
transcript id: NM_001179143.1
SIO_010081: YHR013C
subclass of: SO_0000673
so part of: YHR013C
location: complement(<130730..>131446)
location: region:130730-131446:-1
so has part: feature:130730-131446:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:130730-131446:-1:exon

YHR013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAA10
gene: ARD1
locus tag: YHR013C
gene synonym: NAA10
EC number: 2.3.1.255
experiment: EXISTENCE:direct assay:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:2551674]
experiment: EXISTENCE:direct assay:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]
experiment: EXISTENCE:direct assay:GO:0031415 NatA complex [PMID:14517307]
experiment: EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:2551674]
experiment: EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]
experiment: EXISTENCE:mutant phenotype:GO:0016573 histone acetylation [PMID:17652096]
experiment: EXISTENCE:mutant phenotype:GO:0061606 N-terminal protein amino acid propionylation [PMID:23043182]
note: Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant
codon start: 1
product: peptide alpha-N-acetyltransferase complex A subunit ARD1
translation: MPINIRRATINDIICMQNANLHNLPENYMMKYYMYHILSWPEASFVATTTTLDCEDSDEQDENDKLELTLDGTNDGRTIKLDPTYLAPGEKLVGYVLVKMNDDPDQQNEPPNGHITSLSVMRTYRRMGIAENLMRQALFALREVHQAEYVSLHVRQSNRAALHLYRDTLAFEVLSIEKSYYQDGEDAYAMKKVLKLEELQISNFTHRRLKENEEKLEDDLESDLLEDIIKQGVNDIIV
SIO_010081: YHR013C
subclass of: SO_0000673
so part of: YHR013C
location: complement(130730..131446)
location: region:130730-131446:-1
so has part: feature:130730-131446:-1:exon

NP_011877.1
type: Protein
SIO_000068: ncbiprotein

S000001055
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:130730-131446:-1:exon

YHR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO13
locus tag: YHR014W
so part of: sequence
location: <132047..>132922
location: region:132047-132922:1
so has part: feature:132047-132922:1:exon
subclass of: SO_0000010

856405
type: Gene
SIO_000068: ncbigene

position:132047:1
position: 132047
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:132922:1
position: 132922
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:132047-132922:1:exon

YHR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO13
locus tag: YHR014W
product: Spo13p
transcript id: NM_001179144.1
SIO_010081: YHR014W
subclass of: SO_0000673
so part of: YHR014W
location: <132047..>132922
location: region:132047-132922:1
so has part: feature:132047-132922:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:132047-132922:1:exon

YHR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO13
locus tag: YHR014W
experiment: EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:15620645]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101125]
experiment: EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:17493939]
experiment: EXISTENCE:mutant phenotype:GO:0045876 positive regulation of sister chromatid cohesion [PMID:12101125]
experiment: EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:15620644|PMID:15620645]
experiment: EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219]
note: Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells
codon start: 1
product: Spo13p
translation: MAPRKRFRLLELGSPTHSKRKVQKPLQEKTPNLRVSPLAFKIGKEIKNKEIRKTKKTESENIFNSKHVDLRLESPHPGLNFVSDAQQYSKAGDVRYLKNKSSNTLKNERQTIERPSFDNSLRFEDIEQPPKSTSTPVLSQSSQINVEREAPMFPVPYYIAPSPMYNFSPYQNFVGNPTFLTPSHNPNLNYAIPIQRPELLYPNVNVYDSPLFKKTRLPHQTKSLDKEKNYQYLPIYPVSISNNGDFVGQETPRAAPKLSKKRLSNTLDVNCSDYESSGQNATYNDSESSLN
SIO_010081: YHR014W
subclass of: SO_0000673
so part of: YHR014W
location: 132047..132922
location: region:132047-132922:1
so has part: feature:132047-132922:1:exon

NP_011878.1
type: Protein
SIO_000068: ncbiprotein

S000001056
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:132047-132922:1:exon

YNCH0004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0004C
so part of: sequence
location: complement(133026..133107)
location: region:133026-133107:-1
so has part: feature:133026-133107:-1:exon
subclass of: SO_0000663

856406
type: Gene
SIO_000068: ncbigene

position:133026:-1
position: 133026
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:133107:-1
position: 133107
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133026-133107:-1:exon

YNCH0004C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0004C
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0004C
subclass of: SO_0000673
so part of: YNCH0004C
location: complement(133026..133107)
location: region:133026-133107:-1
so has part: feature:133026-133107:-1:exon

S000006726
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:133026-133107:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(133201..133442)
location: region:133201-133442:-1
so has part: feature:133201-133442:-1:region

S000006994
type: SGD
SIO_000068: sgd

position:133201:-1
position: 133201
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:133442:-1
position: 133442
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133201-133442:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS807; Autonomously Replicating Sequence
so part of: sequence
location: 133438..133539
location: region:133438-133539:1
so has part: feature:133438-133539:1:region

S000118357
type: SGD
SIO_000068: sgd

position:133438:1
position: 133438
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:133539:1
position: 133539
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133438-133539:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(133565..133684)
location: region:133565-133684:-1
so has part: feature:133565-133684:-1:region

S000006995
type: SGD
SIO_000068: sgd

position:133565:-1
position: 133565
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:133684:-1
position: 133684
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133565-133684:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 133685..134009
location: region:133685-134009:1
so has part: feature:133685-134009:1:region

S000007007
type: SGD
SIO_000068: sgd

position:133685:1
position: 133685
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:134009:1
position: 134009
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133685-134009:1:region

YNCH0005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0005W
so part of: sequence
location: 134321..134392
location: region:134321-134392:1
so has part: feature:134321-134392:1:exon
subclass of: SO_0000663

856407
type: Gene
SIO_000068: ncbigene

position:134321:1
position: 134321
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:134392:1
position: 134392
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:134321-134392:1:exon

YNCH0005W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0005W
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCH0005W
subclass of: SO_0000673
so part of: YNCH0005W
location: 134321..134392
location: region:134321-134392:1
so has part: feature:134321-134392:1:exon

S000006698
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:134321-134392:1:exon

YHR015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIP6
locus tag: YHR015W
so part of: sequence
location: <134554..>136533
location: region:134554-136533:1
so has part: feature:134554-136533:1:exon
subclass of: SO_0000010

856408
type: Gene
SIO_000068: ncbigene

position:134554:1
position: 134554
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:136533:1
position: 136533
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:134554-136533:1:exon

YHR015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIP6
locus tag: YHR015W
product: Mip6p
transcript id: NM_001179145.1
SIO_010081: YHR015W
subclass of: SO_0000673
so part of: YHR015W
location: <134554..>136533
location: region:134554-136533:1
so has part: feature:134554-136533:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:134554-136533:1:exon

YHR015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIP6
locus tag: YHR015W
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:28193845]
experiment: EXISTENCE:genetic interaction:GO:0006417 regulation of translation [PMID:28193845]
experiment: EXISTENCE:genetic interaction:GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression [PMID:28193845]
experiment: EXISTENCE:genetic interaction:GO:0016071 mRNA metabolic process [PMID:28193845]
note: mRNA-binding protein; interacts with the UBA domain of mRNA export factor Mex67p; participates in the export of Msn2/4 stress-dependent mRNAs; partially redundant function with paralog PES4 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; redundant role with PES4 in sporulation; shuttles between the nucleus and cytoplasm, localizes to stress granules and the prospore membrane
codon start: 1
product: Mip6p
translation: MPNSHGNVLNNISLNSKQNPRSISKSCPNDKDARQKSFKTISAQALVRVQGAGYKLGDVKLKDAEVKEKNSLKKYDCKNATQEKKEQEQVFEKTVAKGSVQKYITKTSKTNSLFIGNLKSTVTEEMLRKIFKRYQSFESAKVCRDFLTKKSLGYGYLNFKDKNDAESARKEFNYTVFFGQEVKIMPSMKNTLFRKNIGTNVFFSNLPLENPQLTTRSFYLIMIEYGNVLSCLLERRKNIGFVYFDNDISARNVIKKYNNQEFFGNKIICGLHFDKEVRTRPEFTKRKKMIGSDIVIEDELLASNNLSDNARSKTILVKNLPSDTTQEEVLDYFSTIGPIKSVFISEKQANTPHKAFVTYKNEEESKKAQKCLNKTIFKNHTIWVGPGKDKPVHNQIGTNKKTKVYLKNLSFNCNKEFISQLCLQEKIRFSEIKITNYNSLNWTFCGHVECFSRSDAERLFNILDRRLIGSSLVEASWSKNNDNILNEIDYDDGNNNENYKKLINISSMMRFRTQELSAHQKGLTSQFQQVVSPFSSYSNSYTNMNSLVATPMKPHPAFNLITNTVDEKLHQPKRTKQENAEILESLKKIINRNLQRISISGLNKEENLRSISEFIFDVFWEHDSERLSHFLLMTNTSLESQKILQKQVTRAAESLGFTV
SIO_010081: YHR015W
subclass of: SO_0000673
so part of: YHR015W
location: 134554..136533
location: region:134554-136533:1
so has part: feature:134554-136533:1:exon

NP_011879.1
type: Protein
SIO_000068: ncbiprotein

S000001057
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:134554-136533:1:exon

YHR016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LSB4
gene: YSC84
locus tag: YHR016C
gene synonym: LSB4
so part of: sequence
location: complement(<136881..>138455)
location: region:136881-138455:-1
so has part: feature:136881-138455:-1:exon
subclass of: SO_0000010

856409
type: Gene
SIO_000068: ncbigene

position:136881:-1
position: 136881
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:138455:-1
position: 138455
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136881-138455:-1:exon

YHR016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LSB4
gene: YSC84
locus tag: YHR016C
gene synonym: LSB4
product: Ysc84p
transcript id: NM_001179146.1
SIO_010081: YHR016C
subclass of: SO_0000673
so part of: YHR016C
location: complement(join(<136881..138240,138409..>138455))
location: region:136881-138455:-1
so has part: feature:138409-138455:-1:exon
so has part: feature:136881-138240:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138409-138455:-1:exon

position:138409:-1
position: 138409
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:136881-138240:-1:exon

position:138240:-1
position: 138240
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LSB4
gene: YSC84
locus tag: YHR016C
gene synonym: LSB4
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12388763]
experiment: EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:19158382]
experiment: EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:19158382]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12388763]
experiment: EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:12388763]
experiment: EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:19158382]
experiment: EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:19158382]
note: Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication
codon start: 1
product: Ysc84p
translation: MGINNPIPRSLKSETKKAAKVLRSFVKPNQVFGADQVIPPYVLKRAKGLAIITVLKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGVELTDFVFILNSEEAVRSFSEFGTITLGGNVSVSAGPLGRSAEAAASASTGGVSAVFAYSKSKGLFAGVSVEGSAILERREANRKFYGDNCTSKMILSGRVKVPPAADPLLRILESRAFNFTRHDHDDNASGDDFYDDGQYSDNTSHYYDDIPDSFDSTDESSTRPNTRSSRRRGMSLGSRSRYDDDYDDDGYGRGRGYGDFDSEDEDYDYGRSPNRNSSRNRGPQIDRGTKPRANTRWEDDLYDRDTEYSRPNHSGRDYDNTRGNRRGYGRERGYSLGHGPTHPSNMSNVDDLSHKMSKTGLGNESTATNSATPTAVALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVRVS
SIO_010081: YHR016C
subclass of: SO_0000673
so part of: YHR016C
location: complement(join(136881..138240,138409..138455))
location: region:136881-138455:-1
so has part: feature:138409-138455:-1:exon
so has part: feature:136881-138240:-1:exon

NP_011880.1
type: Protein
SIO_000068: ncbiprotein

S000001058
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138409-138455:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:136881-138240:-1:exon

YHR017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YSC83
locus tag: YHR017W
so part of: sequence
location: <138694..>139851
location: region:138694-139851:1
so has part: feature:138694-139851:1:exon
subclass of: SO_0000010

856410
type: Gene
SIO_000068: ncbigene

position:138694:1
position: 138694
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139851:1
position: 139851
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138694-139851:1:exon

YHR017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YSC83
locus tag: YHR017W
product: Ysc83p
transcript id: NM_001179147.1
SIO_010081: YHR017W
subclass of: SO_0000673
so part of: YHR017W
location: <138694..>139851
location: region:138694-139851:1
so has part: feature:138694-139851:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138694-139851:1:exon

YHR017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YSC83
locus tag: YHR017W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
note: Non-essential mitochondrial hypothetical protein; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
codon start: 1
product: Ysc83p
translation: MAWSGGKDIVDQIFDAGYWLVSKSAVLSDEIKNHVEKSIESISGKISNKETPRLQENDSNRSKVYKTLRIGLQDHWKLGLGISATSLCLYLGYRTFFKLPPNLPEAESQVVLILGDMNDPIIRNQVMDLYRRRFTVYICTENADVYKKHEEDQDFIYYIDPTCEKDFEGFFVDVPRLASILFMPRLSYHPSGVISCDSLESEIHSSIFVYYQALLSIIPHLKRKTQLIMFNPSLTADLNLVHHSTEIITSGIIDSLFKIFKEYQRLNVSTIKLGILQIGSQPSNYKFLRMAGSDIHEALHYPVYKMIMSANGYKLRQLLSWLTTLGGYNSVYYCGRFSYLVSWPFASLIFNHHTRLSLKRLRGRLAKVYSSIISFFCRSSSKSSK
SIO_010081: YHR017W
subclass of: SO_0000673
so part of: YHR017W
location: 138694..139851
location: region:138694-139851:1
so has part: feature:138694-139851:1:exon

NP_011881.1
type: Protein
SIO_000068: ncbiprotein

S000001059
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138694-139851:1:exon

YHR018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARG4
locus tag: YHR018C
so part of: sequence
location: complement(<140011..>141402)
location: region:140011-141402:-1
so has part: feature:140011-141402:-1:exon
subclass of: SO_0000010

856411
type: Gene
SIO_000068: ncbigene

position:140011:-1
position: 140011
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141402:-1
position: 141402
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140011-141402:-1:exon

YHR018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARG4
locus tag: YHR018C
product: argininosuccinate lyase ARG4
transcript id: NM_001179148.1
SIO_010081: YHR018C
subclass of: SO_0000673
so part of: YHR018C
location: complement(<140011..>141402)
location: region:140011-141402:-1
so has part: feature:140011-141402:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140011-141402:-1:exon

YHR018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARG4
locus tag: YHR018C
EC number: 4.3.2.1
experiment: EXISTENCE:direct assay:GO:0004056 argininosuccinate lyase activity [PMID:4578972]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]
experiment: EXISTENCE:direct assay:GO:0042450 arginine biosynthetic process via ornithine [PMID:4578972]
note: Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway
codon start: 1
product: argininosuccinate lyase ARG4
translation: MSDGTQKLWGGRFTGETDPLMHLYNASLPYDYKMYKADLEGTKVYTAGLQKLGLLTETELAKIHEGLAEIKKEWDADKFVRHPNDEDIHTANERRLGELIGRDIAGKVHTGRSRNDQVVTDLRIYCRDIVNDTLFPALKGLVEVLIKRAEGEIDVLMPGYTHLQRAQPIRWSHWLSSYATYFTEDYKRLGQILHRLNQSPLGAGALAGHPYGIDREFLAEGLGFNSVIGNSLVAVSDRDFIVELMFWGTLFMNHISRFAEDLIIYCTAEFGFIQLSDAYSTGSSLMPQKKNADSLELLRGKSGRVFGDLTGFLMSLKGIPSTYDKDMQEDKEPLFDCLTTVEHSMLIATGVISTLTVNKEKMEAALTMDMLATDLADYLVRKGVPFRETHHISGECVATAERLGLSGIDKLTLEQYQKIDSRFGQDLFETFNFEQSVERRDATGGTAKSAVLKQLDNLKSQLN
SIO_010081: YHR018C
subclass of: SO_0000673
so part of: YHR018C
location: complement(140011..141402)
location: region:140011-141402:-1
so has part: feature:140011-141402:-1:exon

NP_011882.1
type: Protein
SIO_000068: ncbiprotein

S000001060
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140011-141402:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS2; Autonomously Replicating Sequence
so part of: sequence
location: 140349..141274
location: region:140349-141274:1
so has part: feature:140349-141274:1:region

S000029042
type: SGD
SIO_000068: sgd

position:140349:1
position: 140349
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:141274:1
position: 141274
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140349-141274:1:region

YHR019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DED81
locus tag: YHR019C
so part of: sequence
location: complement(<141894..>143558)
location: region:141894-143558:-1
so has part: feature:141894-143558:-1:exon
subclass of: SO_0000010

856412
type: Gene
SIO_000068: ncbigene

position:141894:-1
position: 141894
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:143558:-1
position: 143558
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141894-143558:-1:exon

YHR019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DED81
locus tag: YHR019C
product: asparagine--tRNA ligase DED81
transcript id: NM_001179149.1
SIO_010081: YHR019C
subclass of: SO_0000673
so part of: YHR019C
location: complement(<141894..>143558)
location: region:141894-143558:-1
so has part: feature:141894-143558:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141894-143558:-1:exon

YHR019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DED81
locus tag: YHR019C
EC number: 6.1.1.22
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9605503]
experiment: EXISTENCE:direct assay:GO:0004816 asparagine-tRNA ligase activity [PMID:9605503]
experiment: EXISTENCE:direct assay:GO:0006421 asparaginyl-tRNA aminoacylation [PMID:9605503]
note: Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
codon start: 1
product: asparagine--tRNA ligase DED81
translation: MSSLYIKEATGVDELTTAGSQDHPFKTPAYALFASQQKSDATEPKLFVFKTEDNEYQEISASALKKARKGCDGLKKKAVKQKEQELKKQQKEAENAAKQLSALNITIKEDESLPAAIKTRIYDSYSKVGQRVKVSGWIHRLRSNKKVIFVVLRDGSGFIQCVLSGDLALAQQTLDLTLESTVTLYGTIVKLPEGKTAPGGVELNVDYYEVVGLAPGGEDSFTNKIAEGSDPSLLLDQRHLALRGDALSAVMKVRAALLKSVRRVYDEEHLTEVTPPCMVQTQVEGGSTLFKMNYYGEEAYLTQSSQLYLETCLASLGDVYTIQESFRAEKSHTRRHLSEYTHIEAELAFLTFDDLLQHIETLIVKSVQYVLEDPIAGPLVKQLNPNFKAPKAPFMRLQYKDAITWLNEHDIKNEEGEDFKFGDDIAEAAERKMTDTIGVPIFLTRFPVEIKSFYMKRCSDDPRVTESVDVLMPNVGEITGGSMRIDDMDELMAGFKREGIDTDAYYWFIDQRKYGTCPHGGYGIGTERILAWLCDRFTVRDCSLYPRFSGRCKP
SIO_010081: YHR019C
subclass of: SO_0000673
so part of: YHR019C
location: complement(141894..143558)
location: region:141894-143558:-1
so has part: feature:141894-143558:-1:exon

NP_011883.1
type: Protein
SIO_000068: ncbiprotein

S000001061
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141894-143558:-1:exon

YHR020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR020W
so part of: sequence
location: <143996..>146062
location: region:143996-146062:1
so has part: feature:143996-146062:1:exon
subclass of: SO_0000010

856413
type: Gene
SIO_000068: ncbigene

position:143996:1
position: 143996
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:146062:1
position: 146062
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:143996-146062:1:exon

YHR020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR020W
product: proline--tRNA ligase
transcript id: NM_001179150.1
SIO_010081: YHR020W
subclass of: SO_0000673
so part of: YHR020W
location: <143996..>146062
location: region:143996-146062:1
so has part: feature:143996-146062:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:143996-146062:1:exon

YHR020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR020W
EC number: 6.1.1.15
experiment: EXISTENCE:direct assay:GO:0004827 proline-tRNA ligase activity [PMID:16864571]
experiment: EXISTENCE:direct assay:GO:0006433 prolyl-tRNA aminoacylation [PMID:16864571]
note: Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
codon start: 1
product: proline--tRNA ligase
translation: MPVSEAFAKLCVNEKPPAESAVAVKSLVFKPKTPKSATPVPIVVVALQSTTTPSALIANATSSKDPRLARDDLVKQAFQSESARAFILGDLANATSNFHLLIDHELGTVDGDTILQLNDSTYMKKSDMMKFLNNFEDSQKVVDFSQEVSKETATEGKKQQKKQQPSKAGTAAAAAAAALEDAKLIGITVDKALDFPGWYQQILTKGEMLDYYDVSGCYILRPPSYAIWENIQKWFDDKIKAIGVQNAYFPMFVSSRVLEKEKDHVEGFAPEVAWVTRAGSSELEEPIAIRPTSETVMYPYYAKWVQSYRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLTAKDAEEEVLQILDFYAGVYEELLAVPVVKGRKTEKEKFAGGDFTTTCEGYIPQTGRGIQGATSHHLGQNFSKMFNLSVENPLGSDHPKIFAYQNSWGLSTRVIGVMVMIHSDNKGLVIPPRVSQFQSVVIPVGITKKTSEEQRKHIHETARSVESRLKKVGIRAFGDYNDNYTPGWKFSQYELKGIPIRIELGPKDIEKNQVVVVRRNDSKKYVVSFDELEARIPEILEEMQGDLFKKAKELFDTHRVIVNEWSGFVPALNKKNVILAPWCGVMECEEDIKESSAKKDDGEEFEEDDKAPSMGAKSLCIPFDQPVLNEGQKCIKCERIAVNYCMFGRSY
SIO_010081: YHR020W
subclass of: SO_0000673
so part of: YHR020W
location: 143996..146062
location: region:143996-146062:1
so has part: feature:143996-146062:1:exon

NP_011884.1
type: Protein
SIO_000068: ncbiprotein

S000001062
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:143996-146062:1:exon

YNCH0006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0006C
so part of: sequence
location: complement(146242..146314)
location: region:146242-146314:-1
so has part: feature:146242-146314:-1:exon
subclass of: SO_0000663

856414
type: Gene
SIO_000068: ncbigene

position:146242:-1
position: 146242
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:146314:-1
position: 146314
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146242-146314:-1:exon

YNCH0006C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0006C
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon AGC (converted to IGC in the mature tRNA), decodes GCU and GCC codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCH0006C
subclass of: SO_0000673
so part of: YNCH0006C
location: complement(146242..146314)
location: region:146242-146314:-1
so has part: feature:146242-146314:-1:exon

S000006513
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:146242-146314:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(146331..146671)
location: region:146331-146671:-1
so has part: feature:146331-146671:-1:region

S000007003
type: SGD
SIO_000068: sgd

position:146331:-1
position: 146331
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:146671:-1
position: 146671
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146331-146671:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 146844..147114
location: region:146844-147114:1
so has part: feature:146844-147114:1:region

S000007010
type: SGD
SIO_000068: sgd

position:146844:1
position: 146844
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:147114:1
position: 147114
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146844-147114:1:region

YHR021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS27B
locus tag: YHR021C
so part of: sequence
location: complement(<147871..>148669)
location: region:147871-148669:-1
so has part: feature:147871-148669:-1:exon
subclass of: SO_0000010

856415
type: Gene
SIO_000068: ncbigene

position:147871:-1
position: 147871
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148669:-1
position: 148669
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:147871-148669:-1:exon

YHR021C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS27B
locus tag: YHR021C
product: ribosomal 40S subunit protein S27B
transcript id: NM_001179151.1
SIO_010081: YHR021C
subclass of: SO_0000673
so part of: YHR021C
location: complement(join(<147871..148116,148667..>148669))
location: region:147871-148669:-1
so has part: feature:148667-148669:-1:exon
so has part: feature:147871-148116:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148667-148669:-1:exon

position:148667:-1
position: 148667
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:147871-148116:-1:exon

position:148116:-1
position: 148116
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR021C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS27B
locus tag: YHR021C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9271380]
experiment: EXISTENCE:mutant phenotype:GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9271380]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S27B
translation: MVLVQDLLHPTAASEARKHKLKTLVQGPRSYFLDVKCPGCLNITTVFSHAQTAVTCESCSTVLCTPTGGKAKLSEGTSFRRK
SIO_010081: YHR021C
subclass of: SO_0000673
so part of: YHR021C
location: complement(join(147871..148116,148667..148669))
location: region:147871-148669:-1
so has part: feature:148667-148669:-1:exon
so has part: feature:147871-148116:-1:exon

NP_011885.1
type: Protein
SIO_000068: ncbiprotein

S000001063
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148667-148669:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:147871-148116:-1:exon

YHR021W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM12
locus tag: YHR021W-A
so part of: sequence
location: <149225..>149680
location: region:149225-149680:1
so has part: feature:149225-149680:1:exon
subclass of: SO_0000010

856416
type: Gene
SIO_000068: ncbigene

position:149225:1
position: 149225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:149680:1
position: 149680
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:149225-149680:1:exon

YHR021W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM12
locus tag: YHR021W-A
product: Ecm12p
transcript id: NM_001181428.1
SIO_010081: YHR021W-A
subclass of: SO_0000673
so part of: YHR021W-A
location: <149225..>149680
location: region:149225-149680:1
so has part: feature:149225-149680:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:149225-149680:1:exon

YHR021W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM12
locus tag: YHR021W-A
note: hypothetical protein; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
codon start: 1
product: Ecm12p
translation: MNRSFHFLIKYIYIHVLLVFYFHIKQQAIMPFFIFFFSSFDGLSFDLRVVAFLAKHVFVGVCSPFFVVGFFGSSRVVVTEWLSKLVLPPPPVSITQVFSLSRKRGEFSSGYILIINPYKSFLRSLLDFSIFNNTAKNKSSTFTLNLEDVSK
SIO_010081: YHR021W-A
subclass of: SO_0000673
so part of: YHR021W-A
location: 149225..149680
location: region:149225-149680:1
so has part: feature:149225-149680:1:exon

NP_011886.1
type: Protein
SIO_000068: ncbiprotein

S000003531
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:149225-149680:1:exon

YHR022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR022C
so part of: sequence
location: complement(<149575..>150345)
location: region:149575-150345:-1
so has part: feature:149575-150345:-1:exon
subclass of: SO_0000010

856417
type: Gene
SIO_000068: ncbigene

position:149575:-1
position: 149575
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150345:-1
position: 150345
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:149575-150345:-1:exon

YHR022C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR022C
product: uncharacterized protein
transcript id: NM_001179152.1
SIO_010081: YHR022C
subclass of: SO_0000673
so part of: YHR022C
location: complement(<149575..>150345)
location: region:149575-150345:-1
so has part: feature:149575-150345:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:149575-150345:-1:exon

YHR022C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR022C
note: hypothetical protein; YHR022C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSVRLSYGASLASIPRCFDLKSSKITVMGDDHSGKTSLVRSWLGSSFQISDANRYRVSDLYHKTIQFDTLVKYYRTFGVKGQLPNYAGFKAKNSGTIYESCGNFLEERLINANKSTAQRRTSIDVQVFDTNQMEVSYLSELTTLQIRQSDAIILCFDSTNDSSLASLESYICIIHHVRLECELDIPIIIACTKCDLDSERTITHEKVLTFIQELGFSPGNLDYFETSSKFNVNVEDLFLAVLLKIEKSKSDRRKLL
SIO_010081: YHR022C
subclass of: SO_0000673
so part of: YHR022C
location: complement(149575..150345)
location: region:149575-150345:-1
so has part: feature:149575-150345:-1:exon

NP_011887.1
type: Protein
SIO_000068: ncbiprotein

S000001064
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:149575-150345:-1:exon

YHR022C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR022C-A
so part of: sequence
location: complement(<151217..>151306)
location: region:151217-151306:-1
so has part: feature:151217-151306:-1:exon
subclass of: SO_0000010

1466527
type: Gene
SIO_000068: ncbigene

position:151217:-1
position: 151217
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:151306:-1
position: 151306
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151217-151306:-1:exon

YHR022C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR022C-A
product: uncharacterized protein
transcript id: NM_001184597.1
SIO_010081: YHR022C-A
subclass of: SO_0000673
so part of: YHR022C-A
location: complement(<151217..>151306)
location: region:151217-151306:-1
so has part: feature:151217-151306:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:151217-151306:-1:exon

YHR022C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR022C-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MKIKFSRGARFSATFSFDKYPFLLYEVVR
SIO_010081: YHR022C-A
subclass of: SO_0000673
so part of: YHR022C-A
location: complement(151217..151306)
location: region:151217-151306:-1
so has part: feature:151217-151306:-1:exon

NP_878087.1
type: Protein
SIO_000068: ncbiprotein

S000028645
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:151217-151306:-1:exon

YHR023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MYO1
locus tag: YHR023W
so part of: sequence
location: <151666..>157452
location: region:151666-157452:1
so has part: feature:151666-157452:1:exon
subclass of: SO_0000010

856418
type: Gene
SIO_000068: ncbigene

position:151666:1
position: 151666
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157452:1
position: 157452
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151666-157452:1:exon

YHR023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MYO1
locus tag: YHR023W
product: myosin 1
transcript id: NM_001179153.1
SIO_010081: YHR023W
subclass of: SO_0000673
so part of: YHR023W
location: <151666..>157452
location: region:151666-157452:1
so has part: feature:151666-157452:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:151666-157452:1:exon

YHR023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MYO1
locus tag: YHR023W
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9732290]
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9442111]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9732290]
experiment: EXISTENCE:direct assay:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:15210731]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:9732290]
experiment: EXISTENCE:mutant phenotype:GO:0031671 primary cell septum biogenesis [PMID:21173112]
experiment: EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:21173112|PMID:9864366|PMID:16148042]
experiment: EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:21173112|PMID:9732290]
experiment: EXISTENCE:mutant phenotype:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:23468521]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:21173112|PMID:23468521|PMID:11082046]
experiment: EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]
experiment: EXISTENCE:physical interaction:GO:0032027 myosin light chain binding [PMID:15210731]
experiment: EXISTENCE:physical interaction:GO:0032033 myosin II light chain binding [PMID:11082046]
note: Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
codon start: 1
product: myosin 1
translation: MTGGQSCSSNMIVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTWDQNSSKFKRSRLKNGFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRETKEQEQKKRNSLVESLNDSKIKELEARLSQEISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLDKEDIIKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLPVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQKDLESTERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEMLNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSSTQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQTLQKLNTDLQLQLKNLHERLSDTTEKNAWLSKIHELENMVSLETDLKYEEMKKNKSLERAVEELQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMAQEIEFWKSRYESTMIGSKNIDSNNAQSKIFS
SIO_010081: YHR023W
subclass of: SO_0000673
so part of: YHR023W
location: 151666..157452
location: region:151666-157452:1
so has part: feature:151666-157452:1:exon

NP_011888.1
type: Protein
SIO_000068: ncbiprotein

S000001065
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:151666-157452:1:exon

YHR024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MIF2
gene: MAS2
locus tag: YHR024C
gene synonym: MIF2
so part of: sequence
location: complement(<157744..>159192)
location: region:157744-159192:-1
so has part: feature:157744-159192:-1:exon
subclass of: SO_0000010

856419
type: Gene
SIO_000068: ncbigene

position:157744:-1
position: 157744
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159192:-1
position: 159192
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:157744-159192:-1:exon

YHR024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MIF2
gene: MAS2
locus tag: YHR024C
gene synonym: MIF2
product: mitochondrial-processing protease subunit alpha
transcript id: NM_001179154.1
SIO_010081: YHR024C
subclass of: SO_0000673
so part of: YHR024C
location: complement(<157744..>159192)
location: region:157744-159192:-1
so has part: feature:157744-159192:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:157744-159192:-1:exon

YHR024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MIF2
gene: MAS2
locus tag: YHR024C
gene synonym: MIF2
experiment: EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:2905264]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0017087 mitochondrial processing peptidase complex [PMID:2905264]
experiment: EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:3061808]
note: Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
codon start: 1
product: mitochondrial-processing protease subunit alpha
translation: MLRNGVQRLYSNIARTDNFKLSSLANGLKVATSNTPGHFSALGLYIDAGSRFEGRNLKGCTHILDRLAFKSTEHVEGRAMAETLELLGGNYQCTSSRENLMYQASVFNQDVGKMLQLMSETVRFPKITEQELQEQKLSAEYEIDEVWMKPELVLPELLHTAAYSGETLGSPLICPRELIPSISKYYLLDYRNKFYTPENTVAAFVGVPHEKALELTEKYLGDWQSTHPPITKKVAQYTGGESCIPPAPVFGNLPELFHIQIGFEGLPIDHPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTHVLNQYYFVENCVAFNHSYSDSGIFGISLSCIPQAAPQAVEVIAQQMYNTFANKDLRLTEDEVSRAKNQLKSSLLMNLESKLVELEDMGRQVLMHGRKIPVNEMISKIEDLKPDDISRVAEMIFTGNVNNAGNGKGRATVVMQGDRGSFGDVENVLKAYGLGNSSSSKNDSPKKKGWF
SIO_010081: YHR024C
subclass of: SO_0000673
so part of: YHR024C
location: complement(157744..159192)
location: region:157744-159192:-1
so has part: feature:157744-159192:-1:exon

NP_011889.1
type: Protein
SIO_000068: ncbiprotein

S000001066
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:157744-159192:-1:exon

YHR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THR1
locus tag: YHR025W
so part of: sequence
location: <159438..>160511
location: region:159438-160511:1
so has part: feature:159438-160511:1:exon
subclass of: SO_0000010

856420
type: Gene
SIO_000068: ncbigene

position:159438:1
position: 159438
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:160511:1
position: 160511
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159438-160511:1:exon

YHR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THR1
locus tag: YHR025W
product: homoserine kinase
transcript id: NM_001179155.1
SIO_010081: YHR025W
subclass of: SO_0000673
so part of: YHR025W
location: <159438..>160511
location: region:159438-160511:1
so has part: feature:159438-160511:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159438-160511:1:exon

YHR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THR1
locus tag: YHR025W
EC number: 2.7.1.39
experiment: EXISTENCE:direct assay:GO:0004413 homoserine kinase activity [PMID:2165904]
experiment: EXISTENCE:direct assay:GO:0009092 homoserine metabolic process [PMID:2165904]
experiment: EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:17247984]
note: Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway
codon start: 1
product: homoserine kinase
translation: MVRAFKIKVPASSANIGPGYDVLGVGLSLFLELDVTIDSSQAQETNDDPNNCKLSYTKESEGYSTVPLRSDANLITRTALYVLRCNNIRNFPSGTKVHVSNPIPLGRGLGSSGAAVVAGVILGNEVAQLGFSKQRMLDYCLMIERHPDNITAAMMGGFCGSFLRDLTPQEVERREIPLAEVLPEPSGGEDTGLVPPLPPTDIGRHVKYQWNPAIKCIAIIPQFELSTADSRGVLPKAYPTQDLVFNLQRLAVLTTALTMDPPNADLIYPAMQDRVHQPYRKTLIPGLTEILSCVTPSTYPGLLGICLSGAGPTILALATENFEEISQEIINRFAKNGIKCSWKLLEPAYDGASVEQQ
SIO_010081: YHR025W
subclass of: SO_0000673
so part of: YHR025W
location: 159438..160511
location: region:159438-160511:1
so has part: feature:159438-160511:1:exon

NP_011890.1
type: Protein
SIO_000068: ncbiprotein

S000001067
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159438-160511:1:exon

YHR026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPA1
gene: VMA16
locus tag: YHR026W
gene synonym: PPA1
so part of: sequence
location: <160844..>161485
location: region:160844-161485:1
so has part: feature:160844-161485:1:exon
subclass of: SO_0000010

856421
type: Gene
SIO_000068: ncbigene

position:160844:1
position: 160844
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:161485:1
position: 161485
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160844-161485:1:exon

YHR026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPA1
gene: VMA16
locus tag: YHR026W
gene synonym: PPA1
product: H(+)-transporting V0 sector ATPase subunit c''
transcript id: NM_001179156.1
SIO_010081: YHR026W
subclass of: SO_0000673
so part of: YHR026W
location: <160844..>161485
location: region:160844-161485:1
so has part: feature:160844-161485:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160844-161485:1:exon

YHR026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPA1
gene: VMA16
locus tag: YHR026W
gene synonym: PPA1
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:9030535]
note: Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
codon start: 1
product: H(+)-transporting V0 sector ATPase subunit c''
translation: MNKESKDDDMSLGKFSFSHFLYYLVLIVVIVYGLYKLFTGHGSDINFGKFLLRTSPYMWANLGIALCVGLSVVGAAWGIFITGSSMIGAGVRAPRITTKNLISIIFCEVVAIYGLIIAIVFSSKLTVATAENMYSKSNLYTGYSLFWAGITVGASNLICGIAVGITGATAAISDAADSALFVKILVIEIFGSILGLLGLIVGLLMAGKASEFQ
SIO_010081: YHR026W
subclass of: SO_0000673
so part of: YHR026W
location: 160844..161485
location: region:160844-161485:1
so has part: feature:160844-161485:1:exon

NP_011891.1
type: Protein
SIO_000068: ncbiprotein

S000001068
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160844-161485:1:exon

YHR027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRD2
alternative label: NAS1
gene: RPN1
locus tag: YHR027C
gene synonym: HRD2; NAS1
so part of: sequence
location: complement(<161730..>164711)
location: region:161730-164711:-1
so has part: feature:161730-164711:-1:exon
subclass of: SO_0000010

856422
type: Gene
SIO_000068: ncbigene

position:161730:-1
position: 161730
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164711:-1
position: 164711
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:161730-164711:-1:exon

YHR027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRD2
alternative label: NAS1
gene: RPN1
locus tag: YHR027C
gene synonym: HRD2; NAS1
product: proteasome regulatory particle base subunit RPN1
transcript id: NM_001179157.1
SIO_010081: YHR027C
subclass of: SO_0000673
so part of: YHR027C
location: complement(<161730..>164711)
location: region:161730-164711:-1
so has part: feature:161730-164711:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:161730-164711:-1:exon

YHR027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRD2
alternative label: NAS1
gene: RPN1
locus tag: YHR027C
gene synonym: HRD2; NAS1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210724|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:12198498]
note: Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle
codon start: 1
product: proteasome regulatory particle base subunit RPN1
translation: MVDESDKKQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLKEDDSSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLSILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVASIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADEEETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGKNDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAMGIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLRQLASYYSREQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAVGLVSPSFMLKHHQLFYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNHGERAELETDEYISYTSHIEGVVILKKNPDYREEE
SIO_010081: YHR027C
subclass of: SO_0000673
so part of: YHR027C
location: complement(161730..164711)
location: region:161730-164711:-1
so has part: feature:161730-164711:-1:exon

NP_011892.1
type: Protein
SIO_000068: ncbiprotein

S000001069
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:161730-164711:-1:exon

YHR028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DPP2
gene: DAP2
locus tag: YHR028C
gene synonym: DPP2
so part of: sequence
location: complement(<164978..>167434)
location: region:164978-167434:-1
so has part: feature:164978-167434:-1:exon
subclass of: SO_0000010

856423
type: Gene
SIO_000068: ncbigene

position:164978:-1
position: 164978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:167434:-1
position: 167434
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164978-167434:-1:exon

YHR028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DPP2
gene: DAP2
locus tag: YHR028C
gene synonym: DPP2
product: dipeptidyl aminopeptidase
transcript id: NM_001179158.1
SIO_010081: YHR028C
subclass of: SO_0000673
so part of: YHR028C
location: complement(<164978..>167434)
location: region:164978-167434:-1
so has part: feature:164978-167434:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164978-167434:-1:exon

YHR028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DPP2
gene: DAP2
locus tag: YHR028C
gene synonym: DPP2
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:2647766|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008239 dipeptidyl-peptidase activity [PMID:2647766]
note: Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
codon start: 1
product: dipeptidyl aminopeptidase
translation: MEGGEEEVERIPDELFDTKKKHLLDKLIRVGIILVLLIWGTVLLLKSIPHHSNTPDYQEPNSNYTNDGKLKVSFSVVRNNTFQPKYHELQWISDNKIESNDLGLYVTFMNDSYVVKSVYDDSYNSVLLEGKTFIHNGQNLTVESITASPDLKRLLIRTNSVQNWRHSTFGSYFVYDKSSSSFEEIGNEVALAIWSPNSNDIAYVQDNNIYIYSAISKKTIRAVTNDGSSFLFNGKPDWVYEEEVFEDDKAAWWSPTGDYLAFLKIDESEVGEFIIPYYVQDEKDIYPEMRSIKYPKSGTPNPHAELWVYSMKDGTSFHPRISGNKKDGSLLITEVTWVGNGNVLVKTTDRSSDILTVFLIDTIAKTSNVVRNESSNGGWWEITHNTLFIPANETFDRPHNGYVDILPIGGYNHLAYFENSNSSHYKTLTEGKWEVVNGPLAFDSMENRLYFISTRKSSTERHVYYIDLRSPNEIIEVTDTSEDGVYDVSFSSGRRFGLLTYKGPKVPYQKIVDFHSRKAEKCDKGNVLGKSLYHLEKNEVLTKILEDYAVPRKSFRELNLGKDEFGKDILVNSYEILPNDFDETLSDHYPVFFFAYGGPNSQQVVKTFSVGFNEVVASQLNAIVVVVDGRGTGFKGQDFRSLVRDRLGDYEARDQISAASLYGSLTFVDPQKISLFGWSYGGYLTLKTLEKDGGRHFKYGMSVAPVTDWRFYDSVYTERYMHTPQENFDGYVESSVHNVTALAQANRFLLMHGTGDDNVHFQNSLKFLDLLDLNGVENYDVHVFPDSDHSIRYHNANVIVFDKLLDWAKRAFDGQFVK
SIO_010081: YHR028C
subclass of: SO_0000673
so part of: YHR028C
location: complement(164978..167434)
location: region:164978-167434:-1
so has part: feature:164978-167434:-1:exon

NP_011893.1
type: Protein
SIO_000068: ncbiprotein

S000001070
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164978-167434:-1:exon

YHR029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YHI9
locus tag: YHR029C
so part of: sequence
location: complement(<167677..>168561)
location: region:167677-168561:-1
so has part: feature:167677-168561:-1:exon
subclass of: SO_0000010

856424
type: Gene
SIO_000068: ncbigene

position:167677:-1
position: 167677
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:168561:-1
position: 168561
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167677-168561:-1:exon

YHR029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YHI9
locus tag: YHR029C
product: Yhi9p
transcript id: NM_001179159.1
SIO_010081: YHR029C
subclass of: SO_0000673
so part of: YHR029C
location: complement(<167677..>168561)
location: region:167677-168561:-1
so has part: feature:167677-168561:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167677-168561:-1:exon

YHR029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YHI9
locus tag: YHR029C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31323700]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]
note: hypothetical protein; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
codon start: 1
product: Yhi9p
translation: MTLMVPFKQVDVFTEKPFMGNPVAVINFLEIDENEVSQEELQAIANWTNLSETTFLFKPSDKKYDYKLRIFTPRSELPFAGHPTIGSCKAFLEFTKNTTATSLVQECKIGAVPITINEGLISFKAPMADYESISSEMIADYEKAIGLKFIKPPALLHTGPEWIVALVEDAETCFNANPNFAMLAHQTKQNDHVGIILAGPKKEAAIKNSYEMRAFAPVINVYEDPVCGSGSVALARYLQEVYKFEKTTDITISEGGRLKRNGLMLASIKKEADNSTSYYIAGHATTVIDGKIKV
SIO_010081: YHR029C
subclass of: SO_0000673
so part of: YHR029C
location: complement(167677..168561)
location: region:167677-168561:-1
so has part: feature:167677-168561:-1:exon

NP_011894.1
type: Protein
SIO_000068: ncbiprotein

S000001071
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167677-168561:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS809; Autonomously Replicating Sequence
so part of: sequence
location: 168549..168723
location: region:168549-168723:1
so has part: feature:168549-168723:1:region

S000118358
type: SGD
SIO_000068: sgd

position:168549:1
position: 168549
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:168723:1
position: 168723
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168549-168723:1:region

YHR030C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BYC2
alternative label: LYT2
alternative label: MPK1
alternative label: SLK2
gene: SLT2
locus tag: YHR030C
gene synonym: BYC2; LYT2; MPK1; SLK2
so part of: sequence
location: complement(<168890..>170344)
location: region:168890-170344:-1
so has part: feature:168890-170344:-1:exon
subclass of: SO_0000010

856425
type: Gene
SIO_000068: ncbigene

position:168890:-1
position: 168890
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:170344:-1
position: 170344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:168890-170344:-1:exon

YHR030C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BYC2
alternative label: LYT2
alternative label: MPK1
alternative label: SLK2
gene: SLT2
locus tag: YHR030C
gene synonym: BYC2; LYT2; MPK1; SLK2
product: mitogen-activated serine/threonine-protein kinase SLT2
transcript id: NM_001179160.1
SIO_010081: YHR030C
subclass of: SO_0000673
so part of: YHR030C
location: complement(<168890..>170344)
location: region:168890-170344:-1
so has part: feature:168890-170344:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:168890-170344:-1:exon

YHR030C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BYC2
alternative label: LYT2
alternative label: MPK1
alternative label: SLK2
gene: SLT2
locus tag: YHR030C
gene synonym: BYC2; LYT2; MPK1; SLK2
EC number: 2.7.11.24
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:20823268|PMID:24554767]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12361575|PMID:23924898|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25598154]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575|PMID:23924898]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12361575|PMID:23924898]
experiment: EXISTENCE:direct assay:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12361575]
experiment: EXISTENCE:genetic interaction:GO:0000196 cell wall integrity MAPK cascade [PMID:8386319|PMID:8386320]
experiment: EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]
experiment: EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:19633265|PMID:27400980]
experiment: EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386319]
experiment: EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:8386319]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]
experiment: EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:20385774]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]
experiment: EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]
experiment: EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:18971375]
experiment: EXISTENCE:mutant phenotype:GO:0042306 regulation of protein import into nucleus [PMID:20219973]
experiment: EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386319]
experiment: EXISTENCE:mutant phenotype:GO:0060256 regulation of flocculation [PMID:31441971]
experiment: EXISTENCE:mutant phenotype:GO:0090364 regulation of proteasome assembly [PMID:27462806]
note: Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway
codon start: 1
product: mitogen-activated serine/threonine-protein kinase SLT2
translation: MADKIERHTFKVFNQDFSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDETLRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYLSIWHDPADEPVCSEKFEFSFESVNDMEDLKQMVIQEVQDFRLFVRQPLLEEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGNAAASEENYPKQMATSNSVAPQQESFGIHSQNLPRHDADFPPRPQESMMEMRPATGNTADIPPQNDNGTLLDLEKELEFGLDRKYF
SIO_010081: YHR030C
subclass of: SO_0000673
so part of: YHR030C
location: complement(168890..170344)
location: region:168890-170344:-1
so has part: feature:168890-170344:-1:exon

NP_011895.1
type: Protein
SIO_000068: ncbiprotein

S000001072
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:168890-170344:-1:exon

YHR031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RTT104
gene: RRM3
locus tag: YHR031C
gene synonym: RTT104
so part of: sequence
location: complement(<170799..>172970)
location: region:170799-172970:-1
so has part: feature:170799-172970:-1:exon
subclass of: SO_0000010

856426
type: Gene
SIO_000068: ncbigene

position:170799:-1
position: 170799
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:172970:-1
position: 172970
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:170799-172970:-1:exon

YHR031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RTT104
gene: RRM3
locus tag: YHR031C
gene synonym: RTT104
product: DNA helicase
transcript id: NM_001179161.1
SIO_010081: YHR031C
subclass of: SO_0000673
so part of: YHR031C
location: complement(<170799..>172970)
location: region:170799-172970:-1
so has part: feature:170799-172970:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:170799-172970:-1:exon

YHR031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RTT104
gene: RRM3
locus tag: YHR031C
gene synonym: RTT104
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:12050116]
experiment: EXISTENCE:direct assay:GO:0005657 replication fork [PMID:17114583|PMID:26411679]
experiment: EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:30442759]
experiment: EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:26981397]
experiment: EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:15907372]
experiment: EXISTENCE:genetic interaction:GO:0071932 replication fork reversal [PMID:26411679]
experiment: EXISTENCE:mutant phenotype:GO:0005657 replication fork [PMID:17114583]
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:10693764]
experiment: EXISTENCE:mutant phenotype:GO:0044806 G-quadruplex DNA unwinding [PMID:23657261]
experiment: EXISTENCE:mutant phenotype:GO:0097046 replication fork progression beyond termination site [PMID:20797631]
experiment: EXISTENCE:mutant phenotype:GO:0098781 ncRNA transcription [PMID:31391265]
note: DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; deletion or inactivation of helicase function suppresses chromosome instability (CIN) associated with centromere or kinetochore defects; structurally and functionally related to Pif1p
codon start: 1
product: DNA helicase
translation: MFRSHASGNKKQWSKRSSNGSTPAASASGSHAYRQQTLSSFFMGCGKKSAAASKNSTTIIDLESGDEGNRNITAPPRPRLIRNNSSSLFSQSQGSFGDDDPDAEFKKLVDVPRLNSYKKSSRSLSMTSSLHKTASASTTQKTYHFDEDETLREVTSVKSNSRQLSFTSTINIEDSSMKLSTDSERPAKRSKPSMEFQGLKLTVPKKIKPLLRKTVSNMDSMNHRSASSPVVLTMEQERVVNLIVKKRTNVFYTGSAGTGKSVILQTIIRQLSSLYGKESIAITASTGLAAVTIGGSTLHKWSGIGIGNKTIDQLVKKIQSQKDLLAAWRYTKVLIIDEISMVDGNLLDKLEQIARRIRKNDDPFGGIQLVLTGDFFQLPPVAKKDEHNVVKFCFESEMWKRCIQKTILLTKVFRQQDNKLIDILNAIRYGELTVDIAKTIRNLNRDIDYADGIAPTELYATRREVELSNVKKLQSLPGDLYEFKAVDNAPERYQAILDSSLMVEKVVALKEDAQVMMLKNKPDVELVNGSLGKVLFFVTESLVVKMKEIYKIVDDEVVMDMRLVSRVIGNPLLKESKEFRQDLNARPLARLERLKILINYAVKISPHKEKFPYVRWTVGKNKYIHELMVPERFPIDIPRENVGLERTQIPLMLCWALSIHKAQGQTIQRLKVDLRRIFEAGQVYVALSRAVTMDTLQVLNFDPGKIRTNERVKDFYKRLETLK
SIO_010081: YHR031C
subclass of: SO_0000673
so part of: YHR031C
location: complement(170799..172970)
location: region:170799-172970:-1
so has part: feature:170799-172970:-1:exon

NP_011896.1
type: Protein
SIO_000068: ncbiprotein

S000001073
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:170799-172970:-1:exon

YHR032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERC1
locus tag: YHR032W
so part of: sequence
location: <173344..>175089
location: region:173344-175089:1
so has part: feature:173344-175089:1:exon
subclass of: SO_0000010

856427
type: Gene
SIO_000068: ncbigene

position:173344:1
position: 173344
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:175089:1
position: 175089
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:173344-175089:1:exon

YHR032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERC1
locus tag: YHR032W
product: Erc1p
transcript id: NM_001179162.1
SIO_010081: YHR032W
subclass of: SO_0000673
so part of: YHR032W
location: <173344..>175089
location: region:173344-175089:1
so has part: feature:173344-175089:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:173344-175089:1:exon

YHR032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERC1
locus tag: YHR032W
experiment: EXISTENCE:mutant phenotype:GO:0006556 S-adenosylmethionine biosynthetic process [PMID:18592490]
note: Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine
codon start: 1
product: Erc1p
translation: MSKQFSHTTNDRRSSIIYSTSVGKAGLFTPADYIPQESEENLIEGEEQEGSEEEPSYTGNDDETEREGEYHSLLDANNSRTLQQEAWQQGYDSHDRKRLLDEERDLLIDNKLLSQHGNGGGDIESHGHGQAIGPDEEERPAEIANTWESAIESGQKISTTFKRETQVITMNALPLIFTFILQNSLSLASIFSVSHLGTKELGGVTLGSMTANITGLAAIQGLCTCLDTLCAQAYGAKNYHLVGVLVQRCAVITILAFLPMMYVWFVWSEKILALMIPERELCALAANYLRVTAFGVPGFILFECGKRFLQCQGIFHASTIVLFVCAPLNALMNYLLVWNDKIGIGYLGAPLSVVINYWLMTLGLLIYAMTTKHKERPLKCWNGIIPKEQAFKNWRKMINLAIPGVVMVEAEFLGFEVLTIFASHLGTDALGAQSIVATIASLAYQVPFSISVSTSTRVANFIGASLYDSCMITCRVSLLLSFVCSSMNMFVICRYKEQIASLFSTESAVVKMVVDTLPLLAFMQLFDAFNASTAGCLRGQGRQKNRWVHQPSRILLPRCAHGICVSIPVSSGCRRLMVGYN
SIO_010081: YHR032W
subclass of: SO_0000673
so part of: YHR032W
location: 173344..175089
location: region:173344-175089:1
so has part: feature:173344-175089:1:exon

NP_011897.1
type: Protein
SIO_000068: ncbiprotein

S000001074
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:173344-175089:1:exon

YHR033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR033W
so part of: sequence
location: <175548..>176819
location: region:175548-176819:1
so has part: feature:175548-176819:1:exon
subclass of: SO_0000010

856428
type: Gene
SIO_000068: ncbigene

position:175548:1
position: 175548
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:176819:1
position: 176819
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175548-176819:1:exon

YHR033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR033W
product: putative glutamate 5-kinase
transcript id: NM_001179163.1
SIO_010081: YHR033W
subclass of: SO_0000673
so part of: YHR033W
location: <175548..>176819
location: region:175548-176819:1
so has part: feature:175548-176819:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175548-176819:1:exon

YHR033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR033W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
note: hypothetical protein; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication
codon start: 1
product: putative glutamate 5-kinase
translation: MTKAYTIVIKLGSSSLVDESTKEPKLSIMTLIVETVTNLKRMGHKVIIVSSGGIAVGLDALNIPHKPKQLSEVQAIAAVGQGRLIARWNMLFSQYGEQTAQILLTRNDILRWNQYNNARNTINELLAMGVIPIVNENDTLSISEIEFGDNDTLSAITAALVGADFLFLLTDVDCLYTDNPRTNPDARPIVLVPELSEGLPGVNTSSGSGSEVGTGGMRTKLIAADLASNAGIETIVMKSDRPEYVPKIVDYIQHHFRPPRHIGNGTQQQFLDLQDTELEQLRRYDVPMHTKFLANDNKHKLKNREFWILHGLITKGAIIIDENSYDKLLSKDMASLTPNAVIEVRDNFHELECVDLKIGQRLPNGELDISKPIQSVGCVRSNYTSLELAKIKGLPSEKIHDVLGYSVSEYVAHRENIAFPPQF
SIO_010081: YHR033W
subclass of: SO_0000673
so part of: YHR033W
location: 175548..176819
location: region:175548-176819:1
so has part: feature:175548-176819:1:exon

NP_011898.1
type: Protein
SIO_000068: ncbiprotein

S000001075
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175548-176819:1:exon

YHR034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NOP17
gene: PIH1
locus tag: YHR034C
gene synonym: NOP17
so part of: sequence
location: complement(<176965..>177999)
location: region:176965-177999:-1
so has part: feature:176965-177999:-1:exon
subclass of: SO_0000010

856429
type: Gene
SIO_000068: ncbigene

position:176965:-1
position: 176965
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:177999:-1
position: 177999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:176965-177999:-1:exon

YHR034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NOP17
gene: PIH1
locus tag: YHR034C
gene synonym: NOP17
product: Pih1p
transcript id: NM_001179164.1
SIO_010081: YHR034C
subclass of: SO_0000673
so part of: YHR034C
location: complement(<176965..>177999)
location: region:176965-177999:-1
so has part: feature:176965-177999:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:176965-177999:-1:exon

YHR034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NOP17
gene: PIH1
locus tag: YHR034C
gene synonym: NOP17
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:15670595]
experiment: EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:15766533]
experiment: EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15670595]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15766533]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27053109]
experiment: EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:15766533]
experiment: EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]
note: Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
codon start: 1
product: Pih1p
translation: MADFLLRPIKQRHRNEDKYVSVDAADGSVSKIEPIADFVIKTKLLSANGPEKLQDGRKVFINVCHSPLVPKPEVDFNARIVFPLIIQNEWEIPIITSCYRMDHDKKGQECYVWDCCINSDCSRWICDDIQLREILVEWCLESCEIRDSVVLCRDRIAFPKMKKKGAELPALEVLNDELHQDYKAKMHKIIEEEAGDPMSILRGRNDDGDDNNDPDDGTLPPLFPIENKISGAKIEEIDKNEIAHRNLKQAPAPAPAPHEQQEDVPEYEVKMKRFKGAAYKLRILIENKAPNSKPDRFSPSYNFAENILYINGKLSIPLPRDIVVNAADIKIFHIRKERTLYIYI
SIO_010081: YHR034C
subclass of: SO_0000673
so part of: YHR034C
location: complement(176965..177999)
location: region:176965-177999:-1
so has part: feature:176965-177999:-1:exon

NP_011899.1
type: Protein
SIO_000068: ncbiprotein

S000001076
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:176965-177999:-1:exon

YHR035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NEL1
locus tag: YHR035W
so part of: sequence
location: <178219..>180111
location: region:178219-180111:1
so has part: feature:178219-180111:1:exon
subclass of: SO_0000010

856430
type: Gene
SIO_000068: ncbigene

position:178219:1
position: 178219
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:180111:1
position: 180111
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178219-180111:1:exon

YHR035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NEL1
locus tag: YHR035W
product: GTPase-activating protein NEL1
transcript id: NM_001179165.1
SIO_010081: YHR035W
subclass of: SO_0000673
so part of: YHR035W
location: <178219..>180111
location: region:178219-180111:1
so has part: feature:178219-180111:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178219-180111:1:exon

YHR035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NEL1
locus tag: YHR035W
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:24947508]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:24947508]
note: Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene
codon start: 1
product: GTPase-activating protein NEL1
translation: MCSPTNFLYEPFSSDAVTQNYDQNLKCTKCGAYYSMACSLREQNVWTCLFCNQSNSNAELPLVPSNTYTLTSAKKEILSRRTIMIIDAICDPHELNYLVSILCNNYITRQQEPLSIITIQQSGHVILHNAVNHRRDAVFSINEFMTKYNLDKLNASYFEKKISEINQESYWFDKSTQGSLRKLLREICKIANKVNISSKRDKRCTGLALFVSSVLASQCSLSAYCHIVSFLNGPCTKGGGKVMSRERGESMRQNHHFESKSSQLQLSKSPTKFYKKMLEKFANQSLIYEFFIASLDQIGILEMSPLITSSMAVSQFDSFNDERFAMSFQKYLNLRDHNAIYNCHSKIMTAKNAIVVKDFPKYSLNPKNLSLPLEISLGHNSAEAPIQFQTTFENQTEKYIRIETLLLPKANRSFGAQNEIVFSMKKIASRIIDSFAYSSKHTKELMKQLFLLPNQIRGKDVDMVNLIQWCYHIYRSPILSVRNTSPDERYLFLHRIINASKDTCLSLCKPFIWSYSDLKHDWIVLDVPLTRAQILQDDKTTICVDGGSYLVLRRGKLLEKEGRELCCKLLNDLQRFPQPLYVETKTGGSQDRFLKSKIIPLDITDKETLGTEDMTFNEYFNLFTDLSGSK
SIO_010081: YHR035W
subclass of: SO_0000673
so part of: YHR035W
location: 178219..180111
location: region:178219-180111:1
so has part: feature:178219-180111:1:exon

NP_011900.1
type: Protein
SIO_000068: ncbiprotein

S000001077
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178219-180111:1:exon

YHR036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRL1
locus tag: YHR036W
so part of: sequence
location: <180345..>181760
location: region:180345-181760:1
so has part: feature:180345-181760:1:exon
subclass of: SO_0000010

856431
type: Gene
SIO_000068: ncbigene

position:180345:1
position: 180345
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:181760:1
position: 181760
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180345-181760:1:exon

YHR036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRL1
locus tag: YHR036W
product: Brl1p
transcript id: NM_001179166.1
SIO_010081: YHR036W
subclass of: SO_0000673
so part of: YHR036W
location: <180345..>181760
location: region:180345-181760:1
so has part: feature:180345-181760:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180345-181760:1:exon

YHR036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRL1
locus tag: YHR036W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15882446|PMID:26432634]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15882446|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15882446]
experiment: EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:26432634]
experiment: EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:15882446]
experiment: EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:26432634]
note: Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p
codon start: 1
product: Brl1p
translation: MESFENLSIRDSFTSGMEHVDEELGGLSDLSISKQGPTLSPQLINRFMPHFPSSPSPLRNTLDFSAAKADEEEDDRMEIDEVDDTSFEEEYNNEPIETHTEATENAVVEEIEATPEERQKQEKNESQDQSVEEVENIVSPHRSTVIKALLSPTDLGVAAATKVEGVVPLPPSANQDDNESSNNNAEGEDIIRNEEVEDEIKSSLGNHKSSQYANAFDSEIIKRELRSRSKYQPIQVSFNTHNYFYSDKDGIKTYSLTKPNHNKIDEFYDQNEAFKLPKPWSPNSHPASRASYALMSYLQLFLNAITTVVIFSFILSFIIALQKDLKSTWEQRKHELQYESRICQEQYLTNRCNQTPGLPALGEQCAIWKQCMDRNNDIFFRARSTLSAKLFGDIINSFIDPLNWKTLFVIFCGVITWCFSSNFLLGFVRAKSYYGNGIKTYPLPSSPKSPTSEETHSSMTASGEDSHLLKQ
SIO_010081: YHR036W
subclass of: SO_0000673
so part of: YHR036W
location: 180345..181760
location: region:180345-181760:1
so has part: feature:180345-181760:1:exon

NP_011901.1
type: Protein
SIO_000068: ncbiprotein

S000001078
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180345-181760:1:exon

YHR037W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUT2
locus tag: YHR037W
so part of: sequence
location: <181977..>183704
location: region:181977-183704:1
so has part: feature:181977-183704:1:exon
subclass of: SO_0000010

856432
type: Gene
SIO_000068: ncbigene

position:181977:1
position: 181977
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:183704:1
position: 183704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:181977-183704:1:exon

YHR037W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUT2
locus tag: YHR037W
product: 1-pyrroline-5-carboxylate dehydrogenase
transcript id: NM_001179167.1
SIO_010081: YHR037W
subclass of: SO_0000673
so part of: YHR037W
location: <181977..>183704
location: region:181977-183704:1
so has part: feature:181977-183704:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:181977-183704:1:exon

YHR037W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUT2
locus tag: YHR037W
EC number: 1.2.1.88
experiment: EXISTENCE:direct assay:GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity [PMID:4145181]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3025596]
experiment: EXISTENCE:direct assay:GO:0006537 glutamate biosynthetic process [PMID:4145181]
experiment: EXISTENCE:mutant phenotype:GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity [PMID:387737]
experiment: EXISTENCE:mutant phenotype:GO:0010133 proline catabolic process to glutamate [PMID:387737]
note: Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant
codon start: 1
product: 1-pyrroline-5-carboxylate dehydrogenase
translation: MLSARCLKSIYFKRSFSQLGHIKPPKHIRNEPVKPFRNIDLKDWDLLRASLMKFKSSSLEVPLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSGTDDKAGGPNILSRFVSIRNTKENFYELTDFKYPSNYE
SIO_010081: YHR037W
subclass of: SO_0000673
so part of: YHR037W
location: 181977..183704
location: region:181977-183704:1
so has part: feature:181977-183704:1:exon

NP_011902.1
type: Protein
SIO_000068: ncbiprotein

S000001079
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:181977-183704:1:exon

YHR038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FIL1
alternative label: KIM4
gene: RRF1
locus tag: YHR038W
gene synonym: FIL1; KIM4
so part of: sequence
location: <184066..>184758
location: region:184066-184758:1
so has part: feature:184066-184758:1:exon
subclass of: SO_0000010

856433
type: Gene
SIO_000068: ncbigene

position:184066:1
position: 184066
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184758:1
position: 184758
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184066-184758:1:exon

YHR038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FIL1
alternative label: KIM4
gene: RRF1
locus tag: YHR038W
gene synonym: FIL1; KIM4
product: Rrf1p
transcript id: NM_001179168.1
SIO_010081: YHR038W
subclass of: SO_0000673
so part of: YHR038W
location: <184066..>184758
location: region:184066-184758:1
so has part: feature:184066-184758:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184066-184758:1:exon

YHR038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FIL1
alternative label: KIM4
gene: RRF1
locus tag: YHR038W
gene synonym: FIL1; KIM4
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12853640|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12853640]
note: Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
codon start: 1
product: Rrf1p
translation: MILTTARLNCRPVTVPRLFNRSFSQSFIILKKKSSTPTEKVEEDEIDVNELLKKAETQFKKTLEIQKQKMNEIKQGNFNPKVFNSLVFKNNRKFTDIATTSLKGKNALLITVFDPKDVKTVISGVLAANLNLTPERVPNNDLQLKVSLPPPTTESRLKVAKDLKRVFEEYKQSSLKDSLGTIRGSILKEFKSFKKDDAVRKAERDLEKLHKDYVNKLHDQFQKVEKSIVK
SIO_010081: YHR038W
subclass of: SO_0000673
so part of: YHR038W
location: 184066..184758
location: region:184066-184758:1
so has part: feature:184066-184758:1:exon

NP_011903.1
type: Protein
SIO_000068: ncbiprotein

S000001080
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184066-184758:1:exon

YHR039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSC7
locus tag: YHR039C
so part of: sequence
location: complement(<184875..>186809)
location: region:184875-186809:-1
so has part: feature:184875-186809:-1:exon
subclass of: SO_0000010

856434
type: Gene
SIO_000068: ncbigene

position:184875:-1
position: 184875
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186809:-1
position: 186809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184875-186809:-1:exon

YHR039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSC7
locus tag: YHR039C
product: meiotic recombination directing protein
transcript id: NM_001179169.1
SIO_010081: YHR039C
subclass of: SO_0000673
so part of: YHR039C
location: complement(<184875..>186809)
location: region:184875-186809:-1
so has part: feature:184875-186809:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184875-186809:-1:exon

YHR039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSC7
locus tag: YHR039C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
codon start: 1
product: meiotic recombination directing protein
translation: MSKVYLNSDMINHLNSTVQAYFNLWLEKQNAIMRSQPQIIQDNQKLIGITTLVASIFTLYVLVKIISTPAKCSSSYKPVKFSLPAPEAAQNNWKGKRSVSTNIWNPEEPNFIQCHCPATGQYLGSFPSKTEADIDEMVSKAGKAQSTWGNSDFSRRLRVLASLHDYILNNQDLIARVACRDSGKTMLDASMGEILVTLEKIQWTIKHGQRALQPSRRPGPTNFFMKWYKGAEIRYEPLGVISSIVSWNYPFHNLLGPIIAALFTGNAIVVKCSEQVVWSSEFFVELIRKCLEACDEDPDLVQLCYCLPPTENDDSANYFTSHPGFKHITFIGSQPVAHYILKCAAKSLTPVVVELGGKDAFIVLDSAKNLDALSSIIMRGTFQSSGQNCIGIERVIVSKENYDDLVKILNDRMTANPLRQGSDIDHLENVDMGAMISDNRFDELEALVKDAVAKGARLLQGGSRFKHPKYPQGHYFQPTLLVDVTPEMKIAQNEVFGPILVMMKAKNTDHCVQLANSAPFGLGGSVFGADIKECNYVANSLQTGNVAINDFATFYVCQLPFGGINGSGYGKFGGEEGLLGLCNAKSVCFDTLPFVSTQIPKPLDYPIRNNAKAWNFVKSFIVGAYTNSTWQRIKSLFSLAKEAS
SIO_010081: YHR039C
subclass of: SO_0000673
so part of: YHR039C
location: complement(184875..186809)
location: region:184875-186809:-1
so has part: feature:184875-186809:-1:exon

NP_011904.1
type: Protein
SIO_000068: ncbiprotein

S000001081
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184875-186809:-1:exon

YHR039C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YHR039C-B
gene: VMA10
locus tag: YHR039C-A
gene synonym: YHR039C-B
so part of: sequence
location: complement(<187173..>187679)
location: region:187173-187679:-1
so has part: feature:187173-187679:-1:exon
subclass of: SO_0000010

856435
type: Gene
SIO_000068: ncbigene

position:187173:-1
position: 187173
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187679:-1
position: 187679
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187173-187679:-1:exon

YHR039C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YHR039C-B
gene: VMA10
locus tag: YHR039C-A
gene synonym: YHR039C-B
product: H(+)-transporting V1 sector ATPase subunit G
transcript id: NM_001180027.1
SIO_010081: YHR039C-A
subclass of: SO_0000673
so part of: YHR039C-A
location: complement(join(<187173..187514,187677..>187679))
location: region:187173-187679:-1
so has part: feature:187677-187679:-1:exon
so has part: feature:187173-187514:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187677-187679:-1:exon

position:187677:-1
position: 187677
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:187173-187514:-1:exon

position:187514:-1
position: 187514
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR039C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YHR039C-B
gene: VMA10
locus tag: YHR039C-A
gene synonym: YHR039C-B
experiment: EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:16774922]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922|PMID:26928762]
note: Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits
codon start: 1
product: H(+)-transporting V1 sector ATPase subunit G
translation: MSQKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAKEIDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELAEIKKIAEKKKDDVVKILIETVIKPSAEVHINAL
SIO_010081: YHR039C-A
subclass of: SO_0000673
so part of: YHR039C-A
location: complement(join(187173..187514,187677..187679))
location: region:187173-187679:-1
so has part: feature:187677-187679:-1:exon
so has part: feature:187173-187514:-1:exon

NP_011905.1
type: Protein
SIO_000068: ncbiprotein

S000002100
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187677-187679:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:187173-187514:-1:exon

YHR040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BCD1
locus tag: YHR040W
so part of: sequence
location: <187924..>189024
location: region:187924-189024:1
so has part: feature:187924-189024:1:exon
subclass of: SO_0000010

856436
type: Gene
SIO_000068: ncbigene

position:187924:1
position: 187924
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:189024:1
position: 189024
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187924-189024:1:exon

YHR040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BCD1
locus tag: YHR040W
product: Bcd1p
transcript id: NM_001179170.1
SIO_010081: YHR040W
subclass of: SO_0000673
so part of: YHR040W
location: <187924..>189024
location: region:187924-189024:1
so has part: feature:187924-189024:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187924-189024:1:exon

YHR040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BCD1
locus tag: YHR040W
experiment: EXISTENCE:direct assay:GO:0000492 box C/D snoRNP assembly [PMID:31537647]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:31537647]
experiment: EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:31537647]
experiment: EXISTENCE:mutant phenotype:GO:0016074 sno(s)RNA metabolic process [PMID:12837249]
note: Essential protein required for the accumulation of box C/D snoRNA
codon start: 1
product: Bcd1p
translation: MAVLCGVCGIKEFKYKCPRCLVQTCSLECSKKHKTRDNCSGQTHDPKEYISSEALKQADDDKHERNAYVQRDYNYLTQLKRMVHVQKMDARMKNKRVLGPVGGHNSNFKKRRYDIDEDDRDSTECQRIIRRGVNCLMLPKGMQRSSQNRSKWDKTMDLFVWSVEWILCPMQEKGEKKELFKHVSHRIKETDFLVQGMGKNVFQKCCEFYRLAGTSSCIEGEDGSETKEERTQILQKSGLKFYTKTFPYNTTHIMDSKKLVELAIHEKCIGELLKNTTVIEFPTIFVAMTEADLPEGYEVLHQEPRPLEHTSTLNKFIDNAREEEDAEEDSQPTEEPVQKETQDASDSDSDSDDDYNPGLSMDFLTA
SIO_010081: YHR040W
subclass of: SO_0000673
so part of: YHR040W
location: 187924..189024
location: region:187924-189024:1
so has part: feature:187924-189024:1:exon

NP_011906.1
type: Protein
SIO_000068: ncbiprotein

S000001082
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187924-189024:1:exon

YHR041C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRS2
alternative label: MED20
gene: SRB2
locus tag: YHR041C
gene synonym: HRS2; MED20
so part of: sequence
location: complement(<189131..>189864)
location: region:189131-189864:-1
so has part: feature:189131-189864:-1:exon
subclass of: SO_0000010

856437
type: Gene
SIO_000068: ncbigene

position:189131:-1
position: 189131
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:189864:-1
position: 189864
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:189131-189864:-1:exon

YHR041C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRS2
alternative label: MED20
gene: SRB2
locus tag: YHR041C
gene synonym: HRS2; MED20
product: Srb2p
transcript id: NM_001179171.1
SIO_010081: YHR041C
subclass of: SO_0000673
so part of: YHR041C
location: complement(join(<189131..189749,189851..>189864))
location: region:189131-189864:-1
so has part: feature:189851-189864:-1:exon
so has part: feature:189131-189749:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:189851-189864:-1:exon

position:189851:-1
position: 189851
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:189131-189749:-1:exon

position:189749:-1
position: 189749
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR041C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRS2
alternative label: MED20
gene: SRB2
locus tag: YHR041C
gene synonym: HRS2; MED20
experiment: EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:1591782]
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:1591782]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:1591782]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:genetic interaction:GO:0019904 protein domain specific binding [PMID:2693207]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15831453]
experiment: EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:18604275]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
codon start: 1
product: Srb2p
translation: MGKSAVIFVERATPATLTELKDALSNSILSVRDPWSIDFRTYRCSIKNLPADVSKLMYSITFHHHGRQTVLIKDNSAMVTTAAAADIPPALVFNGSSTGVPESIDTILSSKLSNIWMQRQLIKGDAGETLILDGLTVRLVNLFSSTGFKGLLIELQADEAGEFETKIAGIEGHLAEIRAKEYKTSSDSLGPDTSNEICDLAYQYVRALEL
SIO_010081: YHR041C
subclass of: SO_0000673
so part of: YHR041C
location: complement(join(189131..189749,189851..189864))
location: region:189131-189864:-1
so has part: feature:189851-189864:-1:exon
so has part: feature:189131-189749:-1:exon

NP_011907.1
type: Protein
SIO_000068: ncbiprotein

S000001083
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:189851-189864:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:189131-189749:-1:exon

YHR042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CPR1
gene: NCP1
locus tag: YHR042W
gene synonym: CPR1
so part of: sequence
location: <190543..>192618
location: region:190543-192618:1
so has part: feature:190543-192618:1:exon
subclass of: SO_0000010

856438
type: Gene
SIO_000068: ncbigene

position:190543:1
position: 190543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:192618:1
position: 192618
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:190543-192618:1:exon

YHR042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CPR1
gene: NCP1
locus tag: YHR042W
gene synonym: CPR1
product: NADPH--hemoprotein reductase
transcript id: NM_001179172.1
SIO_010081: YHR042W
subclass of: SO_0000673
so part of: YHR042W
location: <190543..>192618
location: region:190543-192618:1
so has part: feature:190543-192618:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:190543-192618:1:exon

YHR042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CPR1
gene: NCP1
locus tag: YHR042W
gene synonym: CPR1
EC number: 1.6.2.4
experiment: EXISTENCE:direct assay:GO:0003958 NADPH-hemoprotein reductase activity [PMID:9087488]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:11485306]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9468503]
note: NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
codon start: 1
product: NADPH--hemoprotein reductase
translation: MPFGIDNTDFTVLAGLVLAVLLYVKRNSIKELLMSDDGDITAVSSGNRDIAQVVTENNKNYLVLYASQTGTAEDYAKKFSKELVAKFNLNVMCADVENYDFESLNDVPVIVSIFISTYGEGDFPDGAVNFEDFICNAEAGALSNLRYNMFGLGNSTYEFFNGAAKKAEKHLSAAGAIRLGKLGEADDGAGTTDEDYMAWKDSILEVLKDELHLDEQEAKFTSQFQYTVLNEITDSMSLGEPSAHYLPSHQLNRNADGIQLGPFDLSQPYIAPIVKSRELFSSNDRNCIHSEFDLSGSNIKYSTGDHLAVWPSNPLEKVEQFLSIFNLDPETIFDLKPLDPTVKVPFPTPTTIGAAIKHYLEITGPVSRQLFSSLIQFAPNADVKEKLTLLSKDKDQFAVEITSKYFNIADALKYLSDGAKWDTVPMQFLVESVPQMTPRYYSISSSSLSEKQTVHVTSIVENFPNPELPDAPPVVGVTTNLLRNIQLAQNNVNIAETNLPVHYDLNGPRKLFANYKLPVHVRRSNFRLPSNPSTPVIMIGPGTGVAPFRGFIRERVAFLESQKKGGNNVSLGKHILFYGSRNTDDFLYQDEWPEYAKKLDGSFEMVVAHSRLPNTKKVYVQDKLKDYEDQVFEMINNGAFIYVCGDAKGMAKGVSTALVGILSRGKSITTDEATELIKMLKTSGRYQEDVW
SIO_010081: YHR042W
subclass of: SO_0000673
so part of: YHR042W
location: 190543..192618
location: region:190543-192618:1
so has part: feature:190543-192618:1:exon

NP_011908.1
type: Protein
SIO_000068: ncbiprotein

S000001084
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:190543-192618:1:exon

YHR043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DOG2
locus tag: YHR043C
so part of: sequence
location: complement(<192805..>193545)
location: region:192805-193545:-1
so has part: feature:192805-193545:-1:exon
subclass of: SO_0000010

856439
type: Gene
SIO_000068: ncbigene

position:192805:-1
position: 192805
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:193545:-1
position: 193545
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:192805-193545:-1:exon

YHR043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DOG2
locus tag: YHR043C
product: 2-deoxyglucose-6-phosphatase
transcript id: NM_001179173.1
SIO_010081: YHR043C
subclass of: SO_0000673
so part of: YHR043C
location: complement(<192805..>193545)
location: region:192805-193545:-1
so has part: feature:192805-193545:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:192805-193545:-1:exon

YHR043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DOG2
locus tag: YHR043C
EC number: 3.1.3.68
experiment: EXISTENCE:direct assay:GO:0003850 2-deoxyglucose-6-phosphatase activity [PMID:8553694]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006006 glucose metabolic process [PMID:8553694]
note: 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae
codon start: 1
product: 2-deoxyglucose-6-phosphatase
translation: MPQFSVDLCLFDLDGTIVSTTTAAESAWKKLCRQHGVDPVELFKHSHGARSQEMMKKFFPKLDNTDNKGVLALEKDMADNYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGKPDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVSVVKNNENGIVIQVNNPLTRD
SIO_010081: YHR043C
subclass of: SO_0000673
so part of: YHR043C
location: complement(192805..193545)
location: region:192805-193545:-1
so has part: feature:192805-193545:-1:exon

NP_011909.1
type: Protein
SIO_000068: ncbiprotein

S000001085
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:192805-193545:-1:exon

YHR044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DOG1
locus tag: YHR044C
so part of: sequence
location: complement(<194068..>194808)
location: region:194068-194808:-1
so has part: feature:194068-194808:-1:exon
subclass of: SO_0000010

856440
type: Gene
SIO_000068: ncbigene

position:194068:-1
position: 194068
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194808:-1
position: 194808
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194068-194808:-1:exon

YHR044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DOG1
locus tag: YHR044C
product: 2-deoxyglucose-6-phosphatase
transcript id: NM_001179174.1
SIO_010081: YHR044C
subclass of: SO_0000673
so part of: YHR044C
location: complement(<194068..>194808)
location: region:194068-194808:-1
so has part: feature:194068-194808:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194068-194808:-1:exon

YHR044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DOG1
locus tag: YHR044C
EC number: 3.1.3.68
experiment: EXISTENCE:direct assay:GO:0003850 2-deoxyglucose-6-phosphatase activity [PMID:8553694]
experiment: EXISTENCE:direct assay:GO:0006006 glucose metabolic process [PMID:8553694]
note: 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae
codon start: 1
product: 2-deoxyglucose-6-phosphatase
translation: MAEFSADLCLFDLDGTIVSTTVAAEKAWTKLCYEYGVDPSELFKHSHGARTQEVLRRFFPKLDDTDNKGVLALEKDIAHSYLDTVSLIPGAENLLLSLDVDTETQKKLPERKWAIVTSGSPYLAFSWFETILKNVGKPKVFITGFDVKNGKPDPEGYSRARDLLRQDLQLTGKQDLKYVVFEDAPVGIKAGKAMGAITVGITSSYDKSVLFDAGADYVVCDLTQVSVVKNNENGIVIQVNNPLTRA
SIO_010081: YHR044C
subclass of: SO_0000673
so part of: YHR044C
location: complement(194068..194808)
location: region:194068-194808:-1
so has part: feature:194068-194808:-1:exon

NP_011910.1
type: Protein
SIO_000068: ncbiprotein

S000001086
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194068-194808:-1:exon

YHR045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR045W
so part of: sequence
location: <195551..>197233
location: region:195551-197233:1
so has part: feature:195551-197233:1:exon
subclass of: SO_0000010

856441
type: Gene
SIO_000068: ncbigene

position:195551:1
position: 195551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:197233:1
position: 197233
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:195551-197233:1:exon

YHR045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR045W
product: uncharacterized protein
transcript id: NM_001179175.1
SIO_010081: YHR045W
subclass of: SO_0000673
so part of: YHR045W
location: <195551..>197233
location: region:195551-197233:1
so has part: feature:195551-197233:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:195551-197233:1:exon

YHR045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR045W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
note: hypothetical protein; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
codon start: 1
product: uncharacterized protein
translation: MNWSFLLQLVITILLIVLGANWLLSSFLLDFKRDLTGVALSQQSSISSVRKENETAYYRSILVPTGFPLTTGLGLSLKYKIRNGNFGDVWNAIMEVSKGKNIIKFTGREKSYSLSELNGMAKRIFPKLSNKNFKNIGIANSIATVEGFTLSLASMMTSIRTGSIPHFLPAVPRQRLEDVDVLIIDSWKSFKMLNGSEDWYKLIVVCDDPIESLQFDANCDVITWKELIDGFTKDTEYQYTPPDDNSDDKKLFAYVTSPWNGTNSFNQICLVSNIAEFIKGFPLGNELNSNEYLTISTKLANSSASLQIWGKLFAVLLHGGSASFINPTTIDCESLQETTLLFTETKDVVKLIDSNSRSGLLNKIYLSWATNLLSEGIFTKIARIEPHSLEKLRCVYLADNVKDAEVISTFPEKIPQLKKTNRRITPSTEQLNKIRAQLGSRVVLELYCPYAIMGPVAHTNFYDYRVFGKSVDDNVVCYGTLSTTLEGKMVETETNPHLNIEKKQGMLCIRGFSIGKPVESDRLEKALHLAERFGGGEGWMPLVGVFGLFGQDGCLYIYNQ
SIO_010081: YHR045W
subclass of: SO_0000673
so part of: YHR045W
location: 195551..197233
location: region:195551-197233:1
so has part: feature:195551-197233:1:exon

NP_011911.1
type: Protein
SIO_000068: ncbiprotein

S000001087
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:195551-197233:1:exon

YHR046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INM1
locus tag: YHR046C
so part of: sequence
location: complement(<197398..>198285)
location: region:197398-198285:-1
so has part: feature:197398-198285:-1:exon
subclass of: SO_0000010

856442
type: Gene
SIO_000068: ncbigene

position:197398:-1
position: 197398
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:198285:-1
position: 198285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:197398-198285:-1:exon

YHR046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INM1
locus tag: YHR046C
product: inositol monophosphate 1-phosphatase INM1
transcript id: NM_001179176.1
SIO_010081: YHR046C
subclass of: SO_0000673
so part of: YHR046C
location: complement(<197398..>198285)
location: region:197398-198285:-1
so has part: feature:197398-198285:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:197398-198285:-1:exon

YHR046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INM1
locus tag: YHR046C
EC number: 3.1.3.25
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:10096091]
experiment: EXISTENCE:direct assay:GO:0046855 inositol phosphate dephosphorylation [PMID:10844654]
experiment: EXISTENCE:genetic interaction:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:12593845]
experiment: EXISTENCE:genetic interaction:GO:0046855 inositol phosphate dephosphorylation [PMID:12593845]
note: Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
codon start: 1
product: inositol monophosphate 1-phosphatase INM1
translation: MTIDLASIEKFLCELATEKVGPIIKSKSGTQKDYDLKTGSRSVDIVTAIDKQVEKLIWESVKTQYPTFKFIGEESYVKGETVITDDPTFIIDPIDGTTNFVHDFPFSCTSLGLTVNKEPVVGVIYNPHINLLVSASKGNGMRVNNKDYDYKSKLESMGSLILNKSVVALQPGSAREGKNFQTKMATYEKLLSCDYGFVHGFRNLGSSAMTMAYIAMGYLDSYWDGGCYSWDVCAGWCILKEVGGRVVGANPGEWSIDVDNRTYLAVRGTINNESDEQTKYITDFWNCVDGHLKYD
SIO_010081: YHR046C
subclass of: SO_0000673
so part of: YHR046C
location: complement(197398..198285)
location: region:197398-198285:-1
so has part: feature:197398-198285:-1:exon

NP_011912.1
type: Protein
SIO_000068: ncbiprotein

S000001088
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:197398-198285:-1:exon

YHR047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAP1'
gene: AAP1
locus tag: YHR047C
gene synonym: AAP1'
so part of: sequence
location: complement(<198740..>201310)
location: region:198740-201310:-1
so has part: feature:198740-201310:-1:exon
subclass of: SO_0000010

856443
type: Gene
SIO_000068: ncbigene

position:198740:-1
position: 198740
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201310:-1
position: 201310
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198740-201310:-1:exon

YHR047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAP1'
gene: AAP1
locus tag: YHR047C
gene synonym: AAP1'
product: arginine/alanine aminopeptidase
transcript id: NM_001179177.1
SIO_010081: YHR047C
subclass of: SO_0000673
so part of: YHR047C
location: complement(<198740..>201310)
location: region:198740-201310:-1
so has part: feature:198740-201310:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198740-201310:-1:exon

YHR047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAP1'
gene: AAP1
locus tag: YHR047C
gene synonym: AAP1'
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004177 aminopeptidase activity [PMID:8100228]
experiment: EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:8100228]
experiment: EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:8100228]
note: Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
codon start: 1
product: arginine/alanine aminopeptidase
translation: MSREVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNKNENQQKATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSATFELKNEEFFKINGDQSGIFITSYSDERWAKLSKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHEYDQ
SIO_010081: YHR047C
subclass of: SO_0000673
so part of: YHR047C
location: complement(198740..201310)
location: region:198740-201310:-1
so has part: feature:198740-201310:-1:exon

NP_011913.1
type: Protein
SIO_000068: ncbiprotein

S000001089
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198740-201310:-1:exon

YHR048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YHK8
locus tag: YHR048W
so part of: sequence
location: <204607..>206151
location: region:204607-206151:1
so has part: feature:204607-206151:1:exon
subclass of: SO_0000010

856444
type: Gene
SIO_000068: ncbigene

position:204607:1
position: 204607
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:206151:1
position: 206151
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204607-206151:1:exon

YHR048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YHK8
locus tag: YHR048W
product: Yhk8p
transcript id: NM_001179178.1
SIO_010081: YHR048W
subclass of: SO_0000673
so part of: YHR048W
location: <204607..>206151
location: region:204607-206151:1
so has part: feature:204607-206151:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:204607-206151:1:exon

YHR048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YHK8
locus tag: YHR048W
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
codon start: 1
product: Yhk8p
translation: MVAEFQIASAQSSALTSTEEEHCSINSDKAAKLDLELTSERKNDGKQSHEVTFNEDIADPEDIARHMSTARRYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFITLLITSGCCLVMIIFTIPETYKPMLLIRKAKRLRKEKNDQRYYAVLEVTREQTSLLSAIFLSTKRPFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLFQKTFEWRVKRNNGVKTPEMRFEPLFYGAFLTPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSMGVNWAGFLLAMVTVAMIPVPFLFTKYGARLRAKSPYAWDD
SIO_010081: YHR048W
subclass of: SO_0000673
so part of: YHR048W
location: 204607..206151
location: region:204607-206151:1
so has part: feature:204607-206151:1:exon

NP_011914.1
type: Protein
SIO_000068: ncbiprotein

S000001090
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:204607-206151:1:exon

YHR049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FSH1
locus tag: YHR049W
so part of: sequence
location: <206462..>207193
location: region:206462-207193:1
so has part: feature:206462-207193:1:exon
subclass of: SO_0000010

856445
type: Gene
SIO_000068: ncbigene

position:206462:1
position: 206462
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:207193:1
position: 207193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:206462-207193:1:exon

YHR049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FSH1
locus tag: YHR049W
product: putative serine hydrolase
transcript id: NM_001179179.1
SIO_010081: YHR049W
subclass of: SO_0000673
so part of: YHR049W
location: <206462..>207193
location: region:206462-207193:1
so has part: feature:206462-207193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:206462-207193:1:exon

YHR049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FSH1
locus tag: YHR049W
experiment: EXISTENCE:direct assay:GO:0004622 lysophospholipase activity [PMID:32920715]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:32182256]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:31363875]
note: Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2
codon start: 1
product: putative serine hydrolase
translation: MTVQIPKLLFLHGFLQNGKVFSEKSSGIRKLLKKANVQCDYIDAPVLLEKKDLPFEMDDEKWQATLDADVNRAWFYHSEISHELDISEGLKSVVDHIKANGPYDGIVGFSQGAALSSIITNKISELVPDHPQFKVSVVISGYSFTEPDPEHPGELRITEKFRDSFAVKPDMKTKMIFIYGASDQAVPSVRSKYLYDIYLKAQNGNKEKVLAYEHPGGHMVPNKKDIIRPIVEQITSSLQEASE
SIO_010081: YHR049W
subclass of: SO_0000673
so part of: YHR049W
location: 206462..207193
location: region:206462-207193:1
so has part: feature:206462-207193:1:exon

NP_011915.1
type: Protein
SIO_000068: ncbiprotein

S000001091
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:206462-207193:1:exon

YHR050W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMF2
locus tag: YHR050W
so part of: sequence
location: <207654..>209303
location: region:207654-209303:1
so has part: feature:207654-209303:1:exon
subclass of: SO_0000010

856447
type: Gene
SIO_000068: ncbigene

position:207654:1
position: 207654
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:209303:1
position: 209303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:207654-209303:1:exon

YHR050W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMF2
locus tag: YHR050W
product: divalent metal ion transporter SMF2
transcript id: NM_001179180.1
SIO_010081: YHR050W
subclass of: SO_0000673
so part of: YHR050W
location: <207654..>209303
location: region:207654-209303:1
so has part: feature:207654-209303:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:207654-209303:1:exon

YHR050W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMF2
locus tag: YHR050W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005770 late endosome [PMID:25713143]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:25713143]
experiment: EXISTENCE:direct assay:GO:0022890 inorganic cation transmembrane transporter activity [PMID:10574989]
experiment: EXISTENCE:genetic interaction:GO:0006824 cobalt ion transport [PMID:9115231]
experiment: EXISTENCE:genetic interaction:GO:0006877 cellular cobalt ion homeostasis [PMID:9115231]
experiment: EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:11602606]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:11602606]
note: Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
codon start: 1
product: divalent metal ion transporter SMF2
translation: MTSQEYEPIQWSDESQTNNDSVNDAYADVNTTHESRRRTTLQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTAVAAGSAHRYKLLFSVLVSNFMAAFWQYLCARLGAVTGLDLAQNCKKHLPFGLNITLYILAEMAIIATDLAEVVGTAISLNILFHIPLALGVILTVVDVLIVLLAYKPNGSMKGIRIFEAFVSLLVVLTVVCFTVELFYAKLGPAKEIFSGFLPSKAVFEGDGLYLSLAILGATVMPHSLYLGSGVVQPRLREYDIKNGHYLPDANDMDNNHDNYRPSYEAISETLHFTITELLISLFTVALFVNCAILIVSGATLYGSTQNAEEADLFSIYNLLCSTLSKGAGTVFVLALLFSGQSAGIVCTLSGQMVSEGFLNWTVSPALRRSATRAVAITPCLILVLVAGRSGLSGALNASQVVLSLLLPFVSAPLLYFTSSKKIMRVQLNRTKELSRTTDKKPVADRTEDDETIELEEMGIGSSSQERSLVSPAPEYKDMSNGMIVTVLAIIVWLIISGLNFYMLLGFTTGKEVHL
SIO_010081: YHR050W
subclass of: SO_0000673
so part of: YHR050W
location: 207654..209303
location: region:207654-209303:1
so has part: feature:207654-209303:1:exon

NP_011917.1
type: Protein
SIO_000068: ncbiprotein

S000001092
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:207654-209303:1:exon

YHR050W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR050W-A
so part of: sequence
location: <209475..>209645
location: region:209475-209645:1
so has part: feature:209475-209645:1:exon
subclass of: SO_0000010

1466528
type: Gene
SIO_000068: ncbigene

position:209475:1
position: 209475
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:209645:1
position: 209645
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:209475-209645:1:exon

YHR050W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR050W-A
product: uncharacterized protein
transcript id: NM_001184652.1
SIO_010081: YHR050W-A
subclass of: SO_0000673
so part of: YHR050W-A
location: <209475..>209645
location: region:209475-209645:1
so has part: feature:209475-209645:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:209475-209645:1:exon

YHR050W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR050W-A
note: hypothetical protein; identified by expression profiling and mass spectrometry
codon start: 1
product: uncharacterized protein
translation: MKRDLIGPVKALIKINNCSCLSRCQISRLPHFFTFHPHFSTLIYYYNLKNCITSET
SIO_010081: YHR050W-A
subclass of: SO_0000673
so part of: YHR050W-A
location: 209475..209645
location: region:209475-209645:1
so has part: feature:209475-209645:1:exon

NP_878088.1
type: Protein
SIO_000068: ncbiprotein

S000028832
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:209475-209645:1:exon

YHR051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX6
locus tag: YHR051W
so part of: sequence
location: <209705..>210151
location: region:209705-210151:1
so has part: feature:209705-210151:1:exon
subclass of: SO_0000010

856448
type: Gene
SIO_000068: ncbigene

position:209705:1
position: 209705
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210151:1
position: 210151
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:209705-210151:1:exon

YHR051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX6
locus tag: YHR051W
product: cytochrome c oxidase subunit VI
transcript id: NM_001179181.1
SIO_010081: YHR051W
subclass of: SO_0000673
so part of: YHR051W
location: <209705..>210151
location: region:209705-210151:1
so has part: feature:209705-210151:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:209705-210151:1:exon

YHR051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX6
locus tag: YHR051W
experiment: EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]
note: Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
codon start: 1
product: cytochrome c oxidase subunit VI
translation: MLSRAIFRNPVINRTLLRARPGAYHATRLTKNTFIQSRKYSDAHDEETFEEFTARYEKEFDEAYDLFEVQRVLNNCFSYDLVPAPAVIEKALRAARRVNDLPTAIRVFEALKYKVENEDQYKAYLDELKDVRQELGVPLKEELFPSSS
SIO_010081: YHR051W
subclass of: SO_0000673
so part of: YHR051W
location: 209705..210151
location: region:209705-210151:1
so has part: feature:209705-210151:1:exon

NP_011918.1
type: Protein
SIO_000068: ncbiprotein

S000001093
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:209705-210151:1:exon

YHR052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSA3
gene: CIC1
locus tag: YHR052W
gene synonym: NSA3
so part of: sequence
location: <210848..>211978
location: region:210848-211978:1
so has part: feature:210848-211978:1:exon
subclass of: SO_0000010

856449
type: Gene
SIO_000068: ncbigene

position:210848:1
position: 210848
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:211978:1
position: 211978
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210848-211978:1:exon

YHR052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSA3
gene: CIC1
locus tag: YHR052W
gene synonym: NSA3
product: Cic1p
transcript id: NM_001179182.1
SIO_010081: YHR052W
subclass of: SO_0000673
so part of: YHR052W
location: <210848..>211978
location: region:210848-211978:1
so has part: feature:210848-211978:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210848-211978:1:exon

YHR052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSA3
gene: CIC1
locus tag: YHR052W
gene synonym: NSA3
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11500370]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:11500370]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:21811236]
experiment: EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:11500370]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14623999|PMID:21811236]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14623999]
experiment: EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:11500370]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11500370]
note: Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
codon start: 1
product: Cic1p
translation: MAKKSNSKKSTPVSTPSKEKKKVIEKKSSTAIPRERVIKAVNELIKFTSKPQDENNEEGNNGKKNLLEDDEEELKKDLQLIVVNNKSFTGTSKSFKLKLLNVKHSFYKPWKEASATAVKDFKVLLILKDSDIKKVSEDDLFDQLDSEGIKVDEIICGKDLKTVYKAYEARNAFISQFSLILADDSIVTSLPKLMGGKAYNKVETTPISIRTHANKEFSLTTLTNNIKKVYMNQLPVKLPRGTTLNVHLGNLEWLRPEEFVDNVELISEQLIKAYQIRSIFIKTNRSPVLPLYYNQDVLDELEAKKDKIEETHEDDMVTIDGVQVHLSTFNKGLMEIANPSELGSIFSKQINNAKKRSSSELEKESSESEAVKKAKS
SIO_010081: YHR052W
subclass of: SO_0000673
so part of: YHR052W
location: 210848..211978
location: region:210848-211978:1
so has part: feature:210848-211978:1:exon

NP_011919.1
type: Protein
SIO_000068: ncbiprotein

S000001094
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210848-211978:1:exon

YNCH0007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RUF5-1
locus tag: YNCH0007W
so part of: sequence
location: 212409..213118
location: region:212409-213118:1
so has part: feature:212409-213118:1:exon
subclass of: SO_0000011

9164903
type: Gene
SIO_000068: ncbigene

position:212409:1
position: 212409
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:213118:1
position: 213118
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212409-213118:1:exon

YNCH0007W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: other
gene: RUF5-1
locus tag: YNCH0007W
product: RUF5-1
note: RNA of Unknown Function
transcript id: NR_132186.1
SIO_010081: YNCH0007W
subclass of: SO_0000673
so part of: YNCH0007W
location: 212409..213118
location: region:212409-213118:1
so has part: feature:212409-213118:1:exon

S000028470
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212409-213118:1:exon

YHR052C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR052C-B
so part of: sequence
location: complement(<212519..>212692)
location: region:212519-212692:-1
so has part: feature:212519-212692:-1:exon
subclass of: SO_0000010

65052908
type: Gene
SIO_000068: ncbigene

position:212519:-1
position: 212519
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212692:-1
position: 212692
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212519-212692:-1:exon

YHR052C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR052C-B
product: uncharacterized protein
transcript id: NM_001395031.1
SIO_010081: YHR052C-B
subclass of: SO_0000673
so part of: YHR052C-B
location: complement(<212519..>212692)
location: region:212519-212692:-1
so has part: feature:212519-212692:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212519-212692:-1:exon

YHR052C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR052C-B
note: Novel ORF identified by enrichment-based proteomics
codon start: 1
product: uncharacterized protein
translation: MKVMSANANVVAAKIMNNAKNHVAAQRGVTATTNAPAVTSLKKPRSHAALGNETNSL
SIO_010081: YHR052C-B
subclass of: SO_0000673
so part of: YHR052C-B
location: complement(212519..212692)
location: region:212519-212692:-1
so has part: feature:212519-212692:-1:exon

NP_001381960.1
type: Protein
SIO_000068: ncbiprotein

S000303807
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212519-212692:-1:exon

YHR053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-1
locus tag: YHR053C
gene synonym: CUP1
so part of: sequence
location: complement(<212535..>212720)
location: region:212535-212720:-1
so has part: feature:212535-212720:-1:exon
subclass of: SO_0000010

856450
type: Gene
SIO_000068: ncbigene

position:212535:-1
position: 212535
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:212720:-1
position: 212720
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212535-212720:-1:exon

YHR053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-1
locus tag: YHR053C
gene synonym: CUP1
product: metallothionein CUP1
transcript id: NM_001179185.1
SIO_010081: YHR053C
subclass of: SO_0000673
so part of: YHR053C
location: complement(<212535..>212720)
location: region:212535-212720:-1
so has part: feature:212535-212720:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212535-212720:-1:exon

YHR053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-1
locus tag: YHR053C
gene synonym: CUP1
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:3902832]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3308865|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016209 antioxidant activity [PMID:8367458]
experiment: EXISTENCE:direct assay:GO:0019430 removal of superoxide radicals [PMID:8367458]
experiment: EXISTENCE:direct assay:GO:0046870 cadmium ion binding [PMID:3902832]
experiment: EXISTENCE:genetic interaction:GO:0019430 removal of superoxide radicals [PMID:8367458]
experiment: EXISTENCE:mutant phenotype:GO:0004784 superoxide dismutase activity [PMID:8367458]
experiment: EXISTENCE:mutant phenotype:GO:0010273 detoxification of copper ion [PMID:3536930]
experiment: EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:6370791]
experiment: EXISTENCE:mutant phenotype:GO:0071585 detoxification of cadmium ion [PMID:3536930]
note: Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication
codon start: 1
product: metallothionein CUP1
translation: MFSELINFQNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK
SIO_010081: YHR053C
subclass of: SO_0000673
so part of: YHR053C
location: complement(212535..212720)
location: region:212535-212720:-1
so has part: feature:212535-212720:-1:exon

NP_011922.1
type: Protein
SIO_000068: ncbiprotein

S000001095
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212535-212720:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS810; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 212720..213185
location: region:212720-213185:1
so has part: feature:212720-213185:1:region

S000130147
type: SGD
SIO_000068: sgd

position:212720:1
position: 212720
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:213185:1
position: 213185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212720-213185:1:region

YHR054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR054C
so part of: sequence
location: complement(<213185..>214249)
location: region:213185-214249:-1
so has part: feature:213185-214249:-1:exon
subclass of: SO_0000010

856451
type: Gene
SIO_000068: ncbigene

position:213185:-1
position: 213185
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214249:-1
position: 214249
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:213185-214249:-1:exon

YHR054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR054C
product: uncharacterized protein
transcript id: NM_001179184.1
SIO_010081: YHR054C
subclass of: SO_0000673
so part of: YHR054C
location: complement(<213185..>214249)
location: region:213185-214249:-1
so has part: feature:213185-214249:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:213185-214249:-1:exon

YHR054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR054C
note: hypothetical protein; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication
codon start: 1
product: uncharacterized protein
translation: MVPAAENLSPIPASIDTNDIPLIANDLKLLETQAKLINILQGVPFYLPVNLTKIESLLETLTMGVSNTVDLYFHDNEVRKEWKDTLNFINTIVYTNFFLFVQNESSLSMAVQHSSNNNKTSNSERCAKDLMKIISNMHIFYSITFNFIFPIKSIKSFSSGNNRFHSNGKEFLFANHFIEILQNFIAITFAIFQRCEVILYDEFYKNLSNEEINVQLLLIHDKILEILKKIEIIVSFLRDEMNSNGSFKSIKGFNKVLNLIKYMLRFSKKKQNFARNSDNNNVTDYSQSAKNKNVLLKFPVSELNRIYLKFKEISDFLMEREVVQRSIIIDKDLESDNLGITTANFNDFYDAFYN
SIO_010081: YHR054C
subclass of: SO_0000673
so part of: YHR054C
location: complement(213185..214249)
location: region:213185-214249:-1
so has part: feature:213185-214249:-1:exon

NP_011921.1
type: Protein
SIO_000068: ncbiprotein

S000001096
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:213185-214249:-1:exon

YNCH0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RUF5-2
locus tag: YNCH0008W
so part of: sequence
location: 214407..215116
location: region:214407-215116:1
so has part: feature:214407-215116:1:exon
subclass of: SO_0000011

9164904
type: Gene
SIO_000068: ncbigene

position:214407:1
position: 214407
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:215116:1
position: 215116
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214407-215116:1:exon

YNCH0008W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: other
gene: RUF5-2
locus tag: YNCH0008W
product: RUF5-2
note: RNA of Unknown Function
transcript id: NR_132187.1
SIO_010081: YNCH0008W
subclass of: SO_0000673
so part of: YNCH0008W
location: 214407..215116
location: region:214407-215116:1
so has part: feature:214407-215116:1:exon

S000028474
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214407-215116:1:exon

YHR054C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR054C-B
so part of: sequence
location: complement(<214517..>214690)
location: region:214517-214690:-1
so has part: feature:214517-214690:-1:exon
subclass of: SO_0000010

65052909
type: Gene
SIO_000068: ncbigene

position:214517:-1
position: 214517
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214690:-1
position: 214690
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214517-214690:-1:exon

YHR054C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR054C-B
product: uncharacterized protein
transcript id: NM_001395032.1
SIO_010081: YHR054C-B
subclass of: SO_0000673
so part of: YHR054C-B
location: complement(<214517..>214690)
location: region:214517-214690:-1
so has part: feature:214517-214690:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214517-214690:-1:exon

YHR054C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR054C-B
note: Novel ORF identified by enrichment-based proteomics
codon start: 1
product: uncharacterized protein
translation: MKVMSANANVVAAKIMNNAKNHVAAQRGVTATTNAPAVTSLKKPRSHAALGNETNSL
SIO_010081: YHR054C-B
subclass of: SO_0000673
so part of: YHR054C-B
location: complement(214517..214690)
location: region:214517-214690:-1
so has part: feature:214517-214690:-1:exon

NP_001381961.1
type: Protein
SIO_000068: ncbiprotein

S000303808
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214517-214690:-1:exon

YHR055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-2
locus tag: YHR055C
gene synonym: CUP1
so part of: sequence
location: complement(<214533..>214718)
location: region:214533-214718:-1
so has part: feature:214533-214718:-1:exon
subclass of: SO_0000010

856452
type: Gene
SIO_000068: ncbigene

position:214533:-1
position: 214533
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214718:-1
position: 214718
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214533-214718:-1:exon

YHR055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-2
locus tag: YHR055C
gene synonym: CUP1
product: metallothionein CUP1
transcript id: NM_001179183.1
SIO_010081: YHR055C
subclass of: SO_0000673
so part of: YHR055C
location: complement(<214533..>214718)
location: region:214533-214718:-1
so has part: feature:214533-214718:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214533-214718:-1:exon

YHR055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CUP1
gene: CUP1-2
locus tag: YHR055C
gene synonym: CUP1
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:3902832]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3308865|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016209 antioxidant activity [PMID:8367458]
experiment: EXISTENCE:direct assay:GO:0019430 removal of superoxide radicals [PMID:8367458]
experiment: EXISTENCE:direct assay:GO:0046870 cadmium ion binding [PMID:3902832]
experiment: EXISTENCE:genetic interaction:GO:0019430 removal of superoxide radicals [PMID:8367458]
experiment: EXISTENCE:mutant phenotype:GO:0004784 superoxide dismutase activity [PMID:8367458]
experiment: EXISTENCE:mutant phenotype:GO:0010273 detoxification of copper ion [PMID:3536930]
experiment: EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:6370791]
experiment: EXISTENCE:mutant phenotype:GO:0071585 detoxification of cadmium ion [PMID:3536930]
note: Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication
codon start: 1
product: metallothionein CUP1
translation: MFSELINFQNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGNKSEETKKSCCSGK
SIO_010081: YHR055C
subclass of: SO_0000673
so part of: YHR055C
location: complement(214533..214718)
location: region:214533-214718:-1
so has part: feature:214533-214718:-1:exon

NP_011920.1
type: Protein
SIO_000068: ncbiprotein

S000001097
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214533-214718:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS811; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 214718..215183
location: region:214718-215183:1
so has part: feature:214718-215183:1:region

S000130148
type: SGD
SIO_000068: sgd

position:214718:1
position: 214718
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:215183:1
position: 215183
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214718-215183:1:region

YHR056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSC30
locus tag: YHR056C
so part of: sequence
location: complement(<215183..>217834)
location: region:215183-217834:-1
so has part: feature:215183-217834:-1:exon
subclass of: SO_0000010

856453
type: Gene
SIO_000068: ncbigene

position:215183:-1
position: 215183
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:217834:-1
position: 217834
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215183-217834:-1:exon

YHR056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSC30
locus tag: YHR056C
product: Rsc30p
transcript id: NM_001179186.2
SIO_010081: YHR056C
subclass of: SO_0000673
so part of: YHR056C
location: complement(<215183..>217834)
location: region:215183-217834:-1
so has part: feature:215183-217834:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:215183-217834:-1:exon

YHR056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSC30
locus tag: YHR056C
experiment: EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:32188943]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12183366|PMID:32188943]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:32188943]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11336698]
note: Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication
codon start: 1
product: Rsc30p
translation: MMDMQVRKVRKPPACTQCRKRKIGCDRAKPICGNCVKYNKPDCFYPDGPGKMVAVPSASGMSTHGNGQGSNHFSQGNGVNQKNVMIQTQYPIMQTSIEAFNFSFNPSVDTAMQWTKAASYQNNNTNNNTAPRQNSSTVSSNVHGNTIVRSDSPDVPSMDQIREYNTRLQLVNAQSFDYTDNPYSFNVGINQDSAVFDLMTSPFTQEEVLIKEIDFLKNKLLDLQSLQLKSLKEKSNLNADNTTANKINKTGENSKKGKVDGKRAGFDHQTSRTSQSSQKYFTALTITDVQSLVQVKPLKDTPNYLFTKNFIIFRDHYLFKFYNILHDICHINQFKVSPPNNKNHQQYMEVCKVNFPPKAIIIETLNSESLNNLNIEEFLPIFDKTLLLEFVHNSFPNGDTCPSFSTVDLPLSQLTKLGELTVLLLLLNDSMTLFNKQAINNHVSALMNNLRLIRSQITLINLEYYDQETIKFIAITKFYESLYMHDDHKSSLDEDLSCLLSFQIKDFKLFHFLKKMYYSRHSLLGQSSFMVPAAENLSPIPASIDTNDIPLIANDLKLLETQAKLINILQGVPFYLPVNLTKIESLLETLTMGVSNTVDLYFHDNEVRKEWKDTLNFINTIVYTNFFLFVQNESSLSMAVQHSSNNNKTSNSERCAKDLMKIISNMHIFYSITFNFIFPIKSIKSFSSGNNRFHSNGKEFLFANHFIEILQNFIAITFAIFQRCEVILYDEFYKNLSNEEINVQLLLIHDKILEILKKIEIIVSFLRDEMNSNGSFKSIKGFNKVLNLIKYMLRFSKKKQNFARNSDNNNVTDYSQSAKNKNVLLKFPVSELNRIYLKFKEISDFLMEREVVQRSIIIDKDLESDNLGITTANFNDFYDAFYN
SIO_010081: YHR056C
subclass of: SO_0000673
so part of: YHR056C
location: complement(215183..217834)
location: region:215183-217834:-1
so has part: feature:215183-217834:-1:exon

NP_011923.2
type: Protein
SIO_000068: ncbiprotein

S000001098
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:215183-217834:-1:exon

YHR057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYP2
gene: CPR2
locus tag: YHR057C
gene synonym: CYP2
so part of: sequence
location: complement(<218226..>218843)
location: region:218226-218843:-1
so has part: feature:218226-218843:-1:exon
subclass of: SO_0000010

856454
type: Gene
SIO_000068: ncbigene

position:218226:-1
position: 218226
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:218843:-1
position: 218843
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:218226-218843:-1:exon

YHR057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYP2
gene: CPR2
locus tag: YHR057C
gene synonym: CYP2
product: peptidylprolyl isomerase CPR2
transcript id: NM_001179187.1
SIO_010081: YHR057C
subclass of: SO_0000673
so part of: YHR057C
location: complement(<218226..>218843)
location: region:218226-218843:-1
so has part: feature:218226-218843:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:218226-218843:-1:exon

YHR057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYP2
gene: CPR2
locus tag: YHR057C
gene synonym: CYP2
EC number: 5.2.1.8
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1761234]
note: Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema
codon start: 1
product: peptidylprolyl isomerase CPR2
translation: MKFSGLWCWLLLFLSVNVIASDVGELIDQDDEVITQKVFFDIEHGEEKVGRIVIGLYGKVCPKTAKNFYKLSTTTNSKKGFIGSTFHRVIPNFMVQGGDFTDGTGVGGKSIYGDTFPDENFTLKHDRKGRLSMANRGKDTNGSQFFITTTEEASWLDGKHVVFGQVVDGMDVVNYIQHVSRDANDKPLEAVKIAKCGEWTPELSS
SIO_010081: YHR057C
subclass of: SO_0000673
so part of: YHR057C
location: complement(218226..218843)
location: region:218226-218843:-1
so has part: feature:218226-218843:-1:exon

NP_011924.1
type: Protein
SIO_000068: ncbiprotein

S000001099
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:218226-218843:-1:exon

YHR058C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MED6
locus tag: YHR058C
so part of: sequence
location: complement(<218997..>219884)
location: region:218997-219884:-1
so has part: feature:218997-219884:-1:exon
subclass of: SO_0000010

856455
type: Gene
SIO_000068: ncbigene

position:218997:-1
position: 218997
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:219884:-1
position: 219884
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:218997-219884:-1:exon

YHR058C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MED6
locus tag: YHR058C
product: mediator complex subunit MED6
transcript id: NM_001179188.1
SIO_010081: YHR058C
subclass of: SO_0000673
so part of: YHR058C
location: complement(<218997..>219884)
location: region:218997-219884:-1
so has part: feature:218997-219884:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:218997-219884:-1:exon

YHR058C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MED6
locus tag: YHR058C
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9234719]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9234719]
experiment: EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:9234719]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9234719]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
codon start: 1
product: mediator complex subunit MED6
translation: MNVTPLDELQWKSPEWIQVFGLRTENVLDYFAESPFFDKTSNNQVIKMQRQFSQLNDPNAAVNMTQNIMTLPDGKNGNLEEEFAYVDPARRQILFKYPMYMQLEEELMKLDGTEYVLSSVREPDFWVIRKQRRTNNSGVGSAKGPEIIPLQDYYIIGANIYQSPTIFKIVQSRLMSTSYHLNSTLESLYDLIEFQPSQGVHYKVPTDTSTTATAATNGNNAGGGSNKSSVRPTGGANMATVPSTTNVNMTVNTMGTGGQTIDNGTGRTGNGNMGITTEMLDKLMVTSIRSTPNYI
SIO_010081: YHR058C
subclass of: SO_0000673
so part of: YHR058C
location: complement(218997..219884)
location: region:218997-219884:-1
so has part: feature:218997-219884:-1:exon

NP_011925.1
type: Protein
SIO_000068: ncbiprotein

S000001100
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:218997-219884:-1:exon

YHR059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mS41
gene: FYV4
locus tag: YHR059W
gene synonym: mS41
so part of: sequence
location: <220108..>220500
location: region:220108-220500:1
so has part: feature:220108-220500:1:exon
subclass of: SO_0000010

856456
type: Gene
SIO_000068: ncbigene

position:220108:1
position: 220108
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220500:1
position: 220500
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220108-220500:1:exon

YHR059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mS41
gene: FYV4
locus tag: YHR059W
gene synonym: mS41
product: Fyv4p
transcript id: NM_001179189.1
SIO_010081: YHR059W
subclass of: SO_0000673
so part of: YHR059W
location: <220108..>220500
location: region:220108-220500:1
so has part: feature:220108-220500:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220108-220500:1:exon

YHR059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mS41
gene: FYV4
locus tag: YHR059W
gene synonym: mS41
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]
note: hypothetical protein; required for survival upon exposure to K1 killer toxin
codon start: 1
product: Fyv4p
translation: MIPSRISHKFPLFLRSSLAAPKAAYRFSSTIPKPSDQVPDVDAFLNKIGRNCNELKDTFENNWNNLFQWDSKILKEKGVNIQQRKYILKQVHNYRNNRPIHEIKLGKKSFFGGERKRKAFTAKWKAENKQ
SIO_010081: YHR059W
subclass of: SO_0000673
so part of: YHR059W
location: 220108..220500
location: region:220108-220500:1
so has part: feature:220108-220500:1:exon

NP_011926.1
type: Protein
SIO_000068: ncbiprotein

S000001101
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220108-220500:1:exon

YHR060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CEV1
alternative label: VPH6
gene: VMA22
locus tag: YHR060W
gene synonym: CEV1; VPH6
so part of: sequence
location: <220725..>221270
location: region:220725-221270:1
so has part: feature:220725-221270:1:exon
subclass of: SO_0000010

856457
type: Gene
SIO_000068: ncbigene

position:220725:1
position: 220725
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:221270:1
position: 221270
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:220725-221270:1:exon

YHR060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CEV1
alternative label: VPH6
gene: VMA22
locus tag: YHR060W
gene synonym: CEV1; VPH6
product: Vma22p
transcript id: NM_001179190.1
SIO_010081: YHR060W
subclass of: SO_0000673
so part of: YHR060W
location: <220725..>221270
location: region:220725-221270:1
so has part: feature:220725-221270:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:220725-221270:1:exon

YHR060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CEV1
alternative label: VPH6
gene: VMA22
locus tag: YHR060W
gene synonym: CEV1; VPH6
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:1628805]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:7673216|PMID:8582630]
experiment: EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:7673216]
experiment: EXISTENCE:physical interaction:GO:1990871 Vma12-Vma22 assembly complex [PMID:9660861]
note: Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
codon start: 1
product: Vma22p
translation: MSETRMAQNMDTTDEQYLRLIELLSNYDSTLEQLQKGFQDGYIQLSRSNYYNKDSLRGNYGEDYWDETYIGQLMATVEEKNSKVVVEIVKRKAQDKQEKKEEEDNKLTQRKKGTKPEKQKTQSHKLKQDYDPILMFGGVLSVPSSLRQSQTSFKGCIPLIAQLINYKNEILTLVETLSEQE
SIO_010081: YHR060W
subclass of: SO_0000673
so part of: YHR060W
location: 220725..221270
location: region:220725-221270:1
so has part: feature:220725-221270:1:exon

NP_011927.1
type: Protein
SIO_000068: ncbiprotein

S000001102
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:220725-221270:1:exon

YHR061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIC1
locus tag: YHR061C
so part of: sequence
location: complement(<221534..>222478)
location: region:221534-222478:-1
so has part: feature:221534-222478:-1:exon
subclass of: SO_0000010

856458
type: Gene
SIO_000068: ncbigene

position:221534:-1
position: 221534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222478:-1
position: 222478
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221534-222478:-1:exon

YHR061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIC1
locus tag: YHR061C
product: Gic1p
transcript id: NM_001179191.1
SIO_010081: YHR061C
subclass of: SO_0000673
so part of: YHR061C
location: complement(<221534..>222478)
location: region:221534-222478:-1
so has part: feature:221534-222478:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221534-222478:-1:exon

YHR061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIC1
locus tag: YHR061C
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9367979|PMID:9367980]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9367979|PMID:22842922|PMID:9367980]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9367979]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9367980]
experiment: EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:9367980]
experiment: EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:16371506]
experiment: EXISTENCE:genetic interaction:GO:0032488 Cdc42 protein signal transduction [PMID:9367979]
experiment: EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:14734533]
experiment: EXISTENCE:physical interaction:GO:0031106 septin ring organization [PMID:16371506]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:9367979|PMID:9367980]
note: Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress
codon start: 1
product: Gic1p
translation: MTEGKRLQQMELPQMKSIWIDEDQEMEKLYGFQVRQRFMNGPSTDSDEDADEDLGIVLVDSKKLALPNKNNIKLPPLPNYMTINPNINSNHKSLTNKKKNFLGMFKKKDLLSRRHGSAKTAKQSSISTPFDFHHISHANGKREDNPLESHEEKHDVESLVKFTSLAPQPRPDSNVSSKYSNVVMNDSSRIVSSSTIATTMDSHHDGNETNNTPNGNKQLDSPTDLEMTLEDLRNYTFPSVLGDSVSEKTNPSSPSVSSFSGKFKPRELSALHTPELGNCFNVDQSLNSPGNRISVDDVLKFYYQCSETSTPRNT
SIO_010081: YHR061C
subclass of: SO_0000673
so part of: YHR061C
location: complement(221534..222478)
location: region:221534-222478:-1
so has part: feature:221534-222478:-1:exon

NP_011928.1
type: Protein
SIO_000068: ncbiprotein

S000001103
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221534-222478:-1:exon

YHR062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPP1
locus tag: YHR062C
so part of: sequence
location: complement(<222877..>223758)
location: region:222877-223758:-1
so has part: feature:222877-223758:-1:exon
subclass of: SO_0000010

856459
type: Gene
SIO_000068: ncbigene

position:222877:-1
position: 222877
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:223758:-1
position: 223758
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222877-223758:-1:exon

YHR062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPP1
locus tag: YHR062C
product: RNA-binding RNA processing protein RPP1
transcript id: NM_001179192.1
SIO_010081: YHR062C
subclass of: SO_0000673
so part of: YHR062C
location: complement(<222877..>223758)
location: region:222877-223758:-1
so has part: feature:222877-223758:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:222877-223758:-1:exon

YHR062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPP1
locus tag: YHR062C
EC number: 3.1.26.5
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [PMID:14729943]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23700311]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
experiment: EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9353260|PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9353260|PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9353260|PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9353260|PMID:9620854]
experiment: EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:9353260]
experiment: EXISTENCE:physical interaction:GO:0005655 nucleolar ribonuclease P complex [PMID:9353260]
note: Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: RNA-binding RNA processing protein RPP1
translation: MLVDLNVPWPQNSYADKVTSQAVNNLIKTLSTLHMLGYTHIAINFTVNHSEKFPNDVKLLNPIDIKRRFGELMDRTGLKLYSRITLIIDDPSKGQSLSKISQAFDIVAALPISEKGLTLSTTNLDIDLLTFQYGSRLPTFLKHKSICSCVNRGVKLEIVYGYALRDVQARRQFVSNVRSVIRSSRSRGIVIGSGAMSPLECRNILGVTSLIKNLGLPSDRCSKAMGDLASLVLLNGRLRNKSHKQTIVTGGGSGNGDDVVNDVQGIDDVQTIKVVKRSMDAEQLGHASKRHKP
SIO_010081: YHR062C
subclass of: SO_0000673
so part of: YHR062C
location: complement(222877..223758)
location: region:222877-223758:-1
so has part: feature:222877-223758:-1:exon

NP_011929.1
type: Protein
SIO_000068: ncbiprotein

S000001104
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:222877-223758:-1:exon

YHR063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAN5
locus tag: YHR063C
so part of: sequence
location: complement(<224030..>225169)
location: region:224030-225169:-1
so has part: feature:224030-225169:-1:exon
subclass of: SO_0000010

856460
type: Gene
SIO_000068: ncbigene

position:224030:-1
position: 224030
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225169:-1
position: 225169
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:224030-225169:-1:exon

YHR063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAN5
locus tag: YHR063C
product: 2-dehydropantoate 2-reductase PAN5
transcript id: NM_001179193.1
SIO_010081: YHR063C
subclass of: SO_0000673
so part of: YHR063C
location: complement(<224030..>225169)
location: region:224030-225169:-1
so has part: feature:224030-225169:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:224030-225169:-1:exon

YHR063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAN5
locus tag: YHR063C
EC number: 1.1.1.169
experiment: EXISTENCE:curator inference:GO:0015940 pantothenate biosynthetic process [PMID:11154694]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE
codon start: 1
product: 2-dehydropantoate 2-reductase PAN5
translation: MTAPHRSTIHILGLGAMGTVLAVDLLRFTNALVVPLFRSQERLAQFQKTNGNNISIRKLYLEGSPIFSYPVEKCECPETFSKKPIDNLVVTTKTYQTKEALAPYLPYINKNTNLILIQNGLGVLELLREEIFTDSKNRPHLFQGVISHGVYQDKAGVFNHAGWAGMKIAKLPWTEEEMIQKKSVVEDDAANNSLVKLLTEPKFAKEFGIEHSTYQEMLFGQLFKFLVNACMNPVTAILDCVNGEMKASCGPVFTSIIDECLQILRVAYRPLFQYHEKYSGNEEYPEMDVNAVLTTDNMVSEVTRIGCDINSRNSSSMRQDTLFLRDIEIEYINGYVVKLADNLNLDPNCCKVNKTIGELATMRLALNRSRSINGDWRKD
SIO_010081: YHR063C
subclass of: SO_0000673
so part of: YHR063C
location: complement(224030..225169)
location: region:224030-225169:-1
so has part: feature:224030-225169:-1:exon

NP_011930.1
type: Protein
SIO_000068: ncbiprotein

S000001105
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:224030-225169:-1:exon

YHR064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PDR13
gene: SSZ1
locus tag: YHR064C
gene synonym: PDR13
so part of: sequence
location: complement(<225525..>227141)
location: region:225525-227141:-1
so has part: feature:225525-227141:-1:exon
subclass of: SO_0000010

856461
type: Gene
SIO_000068: ncbigene

position:225525:-1
position: 225525
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:227141:-1
position: 227141
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:225525-227141:-1:exon

YHR064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PDR13
gene: SSZ1
locus tag: YHR064C
gene synonym: PDR13
product: Ssz1p
transcript id: NM_001179194.1
SIO_010081: YHR064C
subclass of: SO_0000673
so part of: YHR064C
location: complement(<225525..>227141)
location: region:225525-227141:-1
so has part: feature:225525-227141:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225525-227141:-1:exon

YHR064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PDR13
gene: SSZ1
locus tag: YHR064C
gene synonym: PDR13
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10792726]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:16413483]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11929994]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]
experiment: EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11054575]
experiment: EXISTENCE:mutant phenotype:GO:0051083 'de novo' cotranslational protein folding [PMID:11274393]
note: Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
codon start: 1
product: Ssz1p
translation: MSSPVIGITFGNTSSSIAYINPKNDVDVIANPDGERAIPSALSYVGEDEYHGGQALQQLIRNPKNTIINFRDFIGLPFDKCDVSKCANGAPAVEVDGKVGFVISRGEGKEEKLTVDEVVSRHLNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQFPFEKDVNVVVADFGGIRSDAAVIAVRNGIFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQANPRKNARSLAKLKANSSITKKTLSNATSATISIDSLADGFDYHASINRMRYELVANKVFAQFSSFVDSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAASGAALQARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFPVQKKLTLKQAKGDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNANGVEIIFNINKDGALRVTARDLKTGNAVKGEL
SIO_010081: YHR064C
subclass of: SO_0000673
so part of: YHR064C
location: complement(225525..227141)
location: region:225525-227141:-1
so has part: feature:225525-227141:-1:exon

NP_011931.2
type: Protein
SIO_000068: ncbiprotein

S000001106
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225525-227141:-1:exon

YHR065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP3
locus tag: YHR065C
so part of: sequence
location: complement(<227532..>229037)
location: region:227532-229037:-1
so has part: feature:227532-229037:-1:exon
subclass of: SO_0000010

856462
type: Gene
SIO_000068: ncbigene

position:227532:-1
position: 227532
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229037:-1
position: 229037
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227532-229037:-1:exon

YHR065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP3
locus tag: YHR065C
product: RNA-dependent ATPase RRP3
transcript id: NM_001179195.1
SIO_010081: YHR065C
subclass of: SO_0000673
so part of: YHR065C
location: complement(<227532..>229037)
location: region:227532-229037:-1
so has part: feature:227532-229037:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:227532-229037:-1:exon

YHR065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP3
locus tag: YHR065C
EC number: 3.6.4.13
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:16449634]
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]
note: Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
codon start: 1
product: RNA-dependent ATPase RRP3
translation: MSKIVKRKEKKANDELTSLAEKIRAKALENQKKLIEAEKEGGSESDSEEDATAEKKKVLKSKSKSTVSTQNENTNEDESFESFSELNLVPELIQACKNLNYSKPTPIQSKAIPPALEGHDIIGLAQTGSGKTAAFAIPILNRLWHDQEPYYACILAPTRELAQQIKETFDSLGSLMGVRSTCIVGGMNMMDQARDLMRKPHIIIATPGRLMDHLENTKGFSLRKLKFLVMDEADRLLDMEFGPVLDRILKIIPTQERTTYLFSATMTSKIDKLQRASLTNPVKCAVSNKYQTVDTLVQTLMVVPGGLKNTYLIYLLNEFIGKTMIIFTRTKANAERLSGLCNLLEFSATALHGDLNQNQRMGSLDLFKAGKRSILVATDVAARGLDIPSVDIVVNYDIPVDSKSYIHRVGRTARAGRSGKSISLVSQYDLELILRIEEVLGKKLPKESVDKNIILTLRDSVDKANGEVVMEMNRRNKEKIARGKGRRGRMMTRENMDMGER
SIO_010081: YHR065C
subclass of: SO_0000673
so part of: YHR065C
location: complement(227532..229037)
location: region:227532-229037:-1
so has part: feature:227532-229037:-1:exon

NP_011932.2
type: Protein
SIO_000068: ncbiprotein

S000001107
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:227532-229037:-1:exon

YHR066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SSF1
locus tag: YHR066W
so part of: sequence
location: <229335..>230696
location: region:229335-230696:1
so has part: feature:229335-230696:1:exon
subclass of: SO_0000010

856463
type: Gene
SIO_000068: ncbigene

position:229335:1
position: 229335
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:230696:1
position: 230696
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229335-230696:1:exon

YHR066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SSF1
locus tag: YHR066W
product: rRNA-binding ribosome biosynthesis protein
transcript id: NM_001179196.1
SIO_010081: YHR066W
subclass of: SO_0000673
so part of: YHR066W
location: <229335..>230696
location: region:229335-230696:1
so has part: feature:229335-230696:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229335-230696:1:exon

YHR066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SSF1
locus tag: YHR066W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9611192]
experiment: EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11864607]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864607]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
note: Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
codon start: 1
product: rRNA-binding ribosome biosynthesis protein
translation: MAKRRQKKRTHAQLTPEQEQGIPKSMVIRVGQTSLANHSLNQLVKDFRQIMQPHTAIKLKERKSNKLKDFVVMCGPLGVTHLFMFTQSEKTGNVSLKIARTPQGPTVTFQVLDYSLGRDIKKFLKRPKSLNNDDVLNPPLLVLNGFSTSKRSGEDDQDVNVEKVIVSMFQNIFPPLNPARTSLNSIKRVFMINKDRETGEISMRHYFIDIREVEISRNLKRLYKAKNNLSKTVPNLHRKEDISSLILDHDLGAYTSESEIEDDAIVRVVDNQDVKAKHSQSLKSQRTPVEKKDNKEREKETEEEDVEMEEPKPSENLQPTPRKKAIKLTELGPRLTLKLVKIEEGICSGKVLHHEFVQKSSEEIKALEKRHAAKMRLKEQRKKEQEENIAKKKAVKDAKKQRKLERRKARAAEGGEGQGKDDAMSDDESSSSDSEHYGSVPEDLDSDLFSEVE
SIO_010081: YHR066W
subclass of: SO_0000673
so part of: YHR066W
location: 229335..230696
location: region:229335-230696:1
so has part: feature:229335-230696:1:exon

NP_011933.1
type: Protein
SIO_000068: ncbiprotein

S000001108
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229335-230696:1:exon

YHR067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RMD12
gene: HTD2
locus tag: YHR067W
gene synonym: RMD12
so part of: sequence
location: <230970..>231812
location: region:230970-231812:1
so has part: feature:230970-231812:1:exon
subclass of: SO_0000010

856464
type: Gene
SIO_000068: ncbigene

position:230970:1
position: 230970
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:231812:1
position: 231812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:230970-231812:1:exon

YHR067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RMD12
gene: HTD2
locus tag: YHR067W
gene synonym: RMD12
product: hydroxyacyl-thioester dehydratase HTD2
transcript id: NM_001179197.1
SIO_010081: YHR067W
subclass of: SO_0000673
so part of: YHR067W
location: <230970..>231812
location: region:230970-231812:1
so has part: feature:230970-231812:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:230970-231812:1:exon

YHR067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RMD12
gene: HTD2
locus tag: YHR067W
gene synonym: RMD12
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15387819|PMID:14562095|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:15387819]
note: Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
codon start: 1
product: hydroxyacyl-thioester dehydratase HTD2
translation: MKSKTWIFRDVLSSHRTKAFDSLLCRRLPVSKATKHLQLGEHFLFFPPSFEKLDRDGYFNYQNPASLLGNPDLRYRRRIWGQGELVQYLPVTLDQEYTCHESIKYVKKIRDEHVVCIERTLLQERPENVSSPMDICLFERRVLMYTNSPANKTAVKMPVGEENYKILKNFTVTDMDIVAYGQMSLNPHRIHWDKEYSRYVEGYDDIIMQGPFSVQLLQKCIQPFLEQPIRQLRYRNLNYIYPNTTLSICQSLSSSSGMYTFQIRDLQKANLVYMKADVFC
SIO_010081: YHR067W
subclass of: SO_0000673
so part of: YHR067W
location: 230970..231812
location: region:230970-231812:1
so has part: feature:230970-231812:1:exon

NP_011934.1
type: Protein
SIO_000068: ncbiprotein

S000001109
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:230970-231812:1:exon

YHR068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DYS1
locus tag: YHR068W
so part of: sequence
location: <232133..>233296
location: region:232133-233296:1
so has part: feature:232133-233296:1:exon
subclass of: SO_0000010

856465
type: Gene
SIO_000068: ncbigene

position:232133:1
position: 232133
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:233296:1
position: 233296
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232133-233296:1:exon

YHR068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DYS1
locus tag: YHR068W
product: deoxyhypusine synthase
transcript id: NM_001179198.1
SIO_010081: YHR068W
subclass of: SO_0000673
so part of: YHR068W
location: <232133..>233296
location: region:232133-233296:1
so has part: feature:232133-233296:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232133-233296:1:exon

YHR068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DYS1
locus tag: YHR068W
EC number: 2.5.1.46
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:7629166]
experiment: EXISTENCE:direct assay:GO:0034038 deoxyhypusine synthase activity [PMID:7629166]
note: Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid
codon start: 1
product: deoxyhypusine synthase
translation: MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN
SIO_010081: YHR068W
subclass of: SO_0000673
so part of: YHR068W
location: 232133..233296
location: region:232133-233296:1
so has part: feature:232133-233296:1:exon

NP_011935.1
type: Protein
SIO_000068: ncbiprotein

S000001110
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232133-233296:1:exon

YHR069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRP4
locus tag: YHR069C
so part of: sequence
location: complement(<233579..>234658)
location: region:233579-234658:-1
so has part: feature:233579-234658:-1:exon
subclass of: SO_0000010

856466
type: Gene
SIO_000068: ncbigene

position:233579:-1
position: 233579
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:234658:-1
position: 234658
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:233579-234658:-1:exon

YHR069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRP4
locus tag: YHR069C
product: exosome non-catalytic core subunit RRP4
transcript id: NM_001179199.1
SIO_010081: YHR069C
subclass of: SO_0000673
so part of: YHR069C
location: complement(<233579..>234658)
location: region:233579-234658:-1
so has part: feature:233579-234658:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:233579-234658:-1:exon

YHR069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRP4
locus tag: YHR069C
experiment: EXISTENCE:curator inference:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0070651 nonfunctional rRNA decay [PMID:10465791]
experiment: EXISTENCE:curator inference:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process [PMID:15828860|PMID:17643380]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11586364]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172|PMID:8600032|PMID:9390555]
experiment: EXISTENCE:mutant phenotype:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:9482746]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10611222]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]
experiment: EXISTENCE:mutant phenotype:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:10611222]
note: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy
codon start: 1
product: exosome non-catalytic core subunit RRP4
translation: MSEVITITKRNGAFQNSSNLSYNNTGISDDENDEEDIYMHDVNSASKSESDSQIVTPGELVTDDPIWMRGHGTYFLDNMTYSSVAGTVSRVNRLLSVIPLKGRYAPETGDHVVGRIAEVGNKRWKVDIGGKQHAVLMLGSVNLPGGILRRKSESDELQMRSFLKEGDLLNAEVQSLFQDGSASLHTRSLKYGKLRNGMFCQVPSSLIVRAKNHTHNLPGNITVVLGVNGYIWLRKTSQMDLARDTPSANNSSSIKSTGPTGAVSLNPSITRLEEESSWQIYSDENDPSISNNIRQAICRYANVIKALAFCEIGITQQRIVSAYEASMVYSNVGELIEKNVMESIGSDILTAEKMRGNGN
SIO_010081: YHR069C
subclass of: SO_0000673
so part of: YHR069C
location: complement(233579..234658)
location: region:233579-234658:-1
so has part: feature:233579-234658:-1:exon

NP_011936.1
type: Protein
SIO_000068: ncbiprotein

S000001111
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:233579-234658:-1:exon

YHR070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRM5
locus tag: YHR070W
so part of: sequence
location: <234881..>236380
location: region:234881-236380:1
so has part: feature:234881-236380:1:exon
subclass of: SO_0000010

856467
type: Gene
SIO_000068: ncbigene

position:234881:1
position: 234881
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:236380:1
position: 236380
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234881-236380:1:exon

YHR070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRM5
locus tag: YHR070W
product: tRNA (guanine) methyltransferase
transcript id: NM_001179200.1
SIO_010081: YHR070W
subclass of: SO_0000673
so part of: YHR070W
location: <234881..>236380
location: region:234881-236380:1
so has part: feature:234881-236380:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234881-236380:1:exon

YHR070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRM5
locus tag: YHR070W
EC number: 2.1.1.228
experiment: EXISTENCE:direct assay:GO:0002939 tRNA N1-guanine methylation [PMID:17652090]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17652090|PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:17652090]
experiment: EXISTENCE:direct assay:GO:0009019 tRNA (guanine-N1-)-methyltransferase activity [PMID:17652090]
experiment: EXISTENCE:direct assay:GO:0070901 mitochondrial tRNA methylation [PMID:17652090]
experiment: EXISTENCE:mutant phenotype:GO:0002939 tRNA N1-guanine methylation [PMID:11226173]
experiment: EXISTENCE:mutant phenotype:GO:0009019 tRNA (guanine-N1-)-methyltransferase activity [PMID:11226173]
note: tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration
codon start: 1
product: tRNA (guanine) methyltransferase
translation: MKIALPVFQKFNRLISSCKMSGVFPYNPPVNRQMRELDRSFFITKIPMCAVKFPEPKNISVFSKNFKNCILRVPRIPHVVKLNSSKPKDELTSVQNKKLKTADGNNTPVTKGVLLHESIHSVEDAYGKLPEDALAFLKENSAEIVPHEYVLDYDFWKAEEILRAVLPEQFLEEVPTGFTITGHIAHLNLRTEFKPFDSLIGQVILDKNNKIECVVDKVSSIATQFRTFPMKVIAGKSDSLVVEQKESNCTFKFDFSKVYWNSRLHTEHERLVKQYFQPGQVVCDVFAGVGPFAVPAGKKDVIVLANDLNPESYKYLKENIALNKVAKTVKSFNMDGADFIRQSPQLLQQWIQDEEGGKITIPLPLKKRHRSQQHNDQQPPQPRTKELIIPSHISHYVMNLPDSAISFLGNFRGIFAAHTKGATDTIQMPWVHVHCFEKYPPGDQVTEDELHARVHARIIAALKVTADDLPLNAVSLHLVRKVAPTKPMYCASFQLPANV
SIO_010081: YHR070W
subclass of: SO_0000673
so part of: YHR070W
location: 234881..236380
location: region:234881-236380:1
so has part: feature:234881-236380:1:exon

NP_011937.1
type: Protein
SIO_000068: ncbiprotein

S000001112
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234881-236380:1:exon

YHR071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCL5
locus tag: YHR071W
so part of: sequence
location: <237004..>237693
location: region:237004-237693:1
so has part: feature:237004-237693:1:exon
subclass of: SO_0000010

856468
type: Gene
SIO_000068: ncbigene

position:237004:1
position: 237004
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237693:1
position: 237693
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:237004-237693:1:exon

YHR071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCL5
locus tag: YHR071W
product: Pcl5p
transcript id: NM_001179201.1
SIO_010081: YHR071W
subclass of: SO_0000673
so part of: YHR071W
location: <237004..>237693
location: region:237004-237693:1
so has part: feature:237004-237693:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:237004-237693:1:exon

YHR071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCL5
locus tag: YHR071W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19218424]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:12101234]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]
experiment: EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:12101234]
experiment: EXISTENCE:mutant phenotype:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:12101234]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:16611745]
note: Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
codon start: 1
product: Pcl5p
translation: MDGNHRFTPDSKEFNTVVKSKESSTGRNPYQTPPLEHNGTHHQTNYSRKKTNLAIIISNFLSEISRPLSNGKINNSTHNILKFLNEVLKRSKCSKENAVLATFYFQKIHQSRGVRDESSLPEFSHCSRRIFLCCLILSHKFLNDNTYSMKNWQIISGLHAKDLSLMERWCLGKLNYELAIPYDEFLLWETNTLMKAKLRVGTPANAPVKRPRESDNDYDANSWKQIKSC
SIO_010081: YHR071W
subclass of: SO_0000673
so part of: YHR071W
location: 237004..237693
location: region:237004-237693:1
so has part: feature:237004-237693:1:exon

NP_011938.1
type: Protein
SIO_000068: ncbiprotein

S000001113
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:237004-237693:1:exon

YNCH0009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0009C
so part of: sequence
location: complement(237848..237939)
location: region:237848-237939:-1
so has part: feature:237848-237939:-1:exon
subclass of: SO_0000663

856469
type: Gene
SIO_000068: ncbigene

position:237848:-1
position: 237848
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:237939:-1
position: 237939
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:237848-237939:-1:exon

YNCH0009C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0009C
product: tRNA-Phe
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0009C
subclass of: SO_0000673
so part of: YNCH0009C
location: complement(join(237848..237883,237903..237939))
location: region:237848-237939:-1
so has part: feature:237903-237939:-1:exon
so has part: feature:237848-237883:-1:exon

S000006566
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:237903-237939:-1:exon

position:237903:-1
position: 237903
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:237848-237883:-1:exon

position:237883:-1
position: 237883
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG7
locus tag: YHR072W
so part of: sequence
location: <239098..>241293
location: region:239098-241293:1
so has part: feature:239098-241293:1:exon
subclass of: SO_0000010

856470
type: Gene
SIO_000068: ncbigene

position:239098:1
position: 239098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241293:1
position: 241293
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:239098-241293:1:exon

YHR072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG7
locus tag: YHR072W
product: lanosterol synthase ERG7
transcript id: NM_001179202.2
SIO_010081: YHR072W
subclass of: SO_0000673
so part of: YHR072W
location: <239098..>241293
location: region:239098-241293:1
so has part: feature:239098-241293:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239098-241293:1:exon

YHR072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG7
locus tag: YHR072W
EC number: 5.4.99.7
experiment: EXISTENCE:direct assay:GO:0000250 lanosterol synthase activity [PMID:12842197]
experiment: EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:11706015|PMID:24868093]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:12842197]
experiment: EXISTENCE:mutant phenotype:GO:0000250 lanosterol synthase activity [PMID:18842050]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]
note: Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation
codon start: 1
product: lanosterol synthase ERG7
translation: MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL
SIO_010081: YHR072W
subclass of: SO_0000673
so part of: YHR072W
location: 239098..241293
location: region:239098-241293:1
so has part: feature:239098-241293:1:exon

NP_011939.2
type: Protein
SIO_000068: ncbiprotein

S000001114
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239098-241293:1:exon

YHR072W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP10
locus tag: YHR072W-A
so part of: sequence
location: <241664..>241840
location: region:241664-241840:1
so has part: feature:241664-241840:1:exon
subclass of: SO_0000010

856471
type: Gene
SIO_000068: ncbigene

position:241664:1
position: 241664
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241840:1
position: 241840
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241664-241840:1:exon

YHR072W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP10
locus tag: YHR072W-A
product: snoRNP complex protein NOP10
transcript id: NM_001184438.1
SIO_010081: YHR072W-A
subclass of: SO_0000673
so part of: YHR072W-A
location: <241664..>241840
location: region:241664-241840:1
so has part: feature:241664-241840:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241664-241840:1:exon

YHR072W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP10
locus tag: YHR072W-A
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9843512]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9843512]
experiment: EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:mutant phenotype:GO:0000469 cleavage involved in rRNA processing [PMID:9843512]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9843512]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9843512]
note: Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA
codon start: 1
product: snoRNP complex protein NOP10
translation: MHLMYTLGPDGKRIYTLKKVTESGEITKSAHPARFSPDDKYSRQRVTLKKRFGLVPGQ
SIO_010081: YHR072W-A
subclass of: SO_0000673
so part of: YHR072W-A
location: 241664..241840
location: region:241664-241840:1
so has part: feature:241664-241840:1:exon

NP_058135.1
type: Protein
SIO_000068: ncbiprotein

S000007455
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241664-241840:1:exon

YHR073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OSH3
locus tag: YHR073W
so part of: sequence
location: <242582..>245572
location: region:242582-245572:1
so has part: feature:242582-245572:1:exon
subclass of: SO_0000010

856472
type: Gene
SIO_000068: ncbigene

position:242582:1
position: 242582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245572:1
position: 245572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:242582-245572:1:exon

YHR073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OSH3
locus tag: YHR073W
product: oxysterol-binding protein related protein OSH3
transcript id: NM_001179203.1
SIO_010081: YHR073W
subclass of: SO_0000673
so part of: YHR073W
location: <242582..>245572
location: region:242582-245572:1
so has part: feature:242582-245572:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:242582-245572:1:exon

YHR073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OSH3
locus tag: YHR073W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11408574]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25420878]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0010922 positive regulation of phosphatase activity [PMID:21295699]
experiment: EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]
experiment: EXISTENCE:genetic interaction:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12054531]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12054531]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]
experiment: EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]
experiment: EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:12054531|PMID:17082746]
experiment: EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:16585271]
experiment: EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]
note: Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding
codon start: 1
product: oxysterol-binding protein related protein OSH3
translation: METIDIQNRSFVVRWVKCGRGDVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDTKTLLDYTTKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQEIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFNASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDKIIIIDSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLNGTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRFVTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIVEETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAASPPSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYRDKTRTLRKPFNPLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLANETTHETIWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERRNKGQDVEPKYFEKVSKNEWKYITGPKSYWERRKKHDWSDISQLW
SIO_010081: YHR073W
subclass of: SO_0000673
so part of: YHR073W
location: 242582..245572
location: region:242582-245572:1
so has part: feature:242582-245572:1:exon

NP_011940.1
type: Protein
SIO_000068: ncbiprotein

S000001115
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:242582-245572:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS813; Autonomously Replicating Sequence
so part of: sequence
location: 245773..245847
location: region:245773-245847:1
so has part: feature:245773-245847:1:region

S000118359
type: SGD
SIO_000068: sgd

position:245773:1
position: 245773
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:245847:1
position: 245847
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245773-245847:1:region

YHR074W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: QNS1
locus tag: YHR074W
so part of: sequence
location: <246193..>248337
location: region:246193-248337:1
so has part: feature:246193-248337:1:exon
subclass of: SO_0000010

856473
type: Gene
SIO_000068: ncbigene

position:246193:1
position: 246193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248337:1
position: 248337
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246193-248337:1:exon

YHR074W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: QNS1
locus tag: YHR074W
product: glutamine-dependent NAD(+) synthetase
transcript id: NM_001179204.1
SIO_010081: YHR074W
subclass of: SO_0000673
so part of: YHR074W
location: <246193..>248337
location: region:246193-248337:1
so has part: feature:246193-248337:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246193-248337:1:exon

YHR074W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: QNS1
locus tag: YHR074W
EC number: 6.3.5.1
experiment: EXISTENCE:direct assay:GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity [PMID:12898714|PMID:12771147]
experiment: EXISTENCE:direct assay:GO:0004359 glutaminase activity [PMID:12771147]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12898714]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12898714]
experiment: EXISTENCE:direct assay:GO:0009435 NAD biosynthetic process [PMID:12771147|PMID:12898714]
experiment: EXISTENCE:mutant phenotype:GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity [PMID:12898714|PMID:12771147]
experiment: EXISTENCE:mutant phenotype:GO:0004359 glutaminase activity [PMID:12771147]
experiment: EXISTENCE:mutant phenotype:GO:0009435 NAD biosynthetic process [PMID:12771147|PMID:12898714]
note: Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
codon start: 1
product: glutamine-dependent NAD(+) synthetase
translation: MSHLITLATCNLNQWALDFEGNRDRILQSIKIAKERGARLRVGPELEITGYGCLDHFLENDVCLHSWEMYAQIIKNKETHGLILDIGMPVLHKNVRYNCRLLSLDGEILFIRPKIWLANDGNYREMRFFTPWMKPGVVEDFILPPEIQKVTGQRLVPFGDAVINSLDTCIGTETCEELFTPQSPHIAMSLDGVEIMTNSSGSHHELRKLNKRLDLILNATKRCGGVYLYANQRGCDGDRLYYDGCALIAINGTIVAQGSQFSLDDVEVVTATVDLEEVRSYRAAVMSRGLQASLAEIKFKRIDIPVELALMTSRFDPTVCPTKVREPFYHSPEEEIALGPACWMWDYLRRCNGTGFFLPLSGGIDSCATAMIVHSMCRLVTDAAQNGNEQVIKDVRKITRSGDDWIPDSPQDLASKIFHSCFMGTENSSKETRNRAKDLSNAIGSYHVDLKMDSLVSSVVSLFEVATGKKPIYKIFGGSQIENLALQNIQARLRMVLSYLFAQLLPWVRGIPNSGGLLVLGSANVDECLRGYLTKYDCSSADINPIGGISKTDLKRFIAYASKQYNMPILNDFLNATPTAELEPMTKDYVQSDEIDMGMTYEELGVFGYLRKVEKCGPYSMFLKLLHQWSPKLTPRQISEKVKRFFFFYAINRHKQTVLTPSYHAEQYSPEDNRFDLRPFLINPRFPWASRKIDEVVEQCEAHKGSTLDIMSID
SIO_010081: YHR074W
subclass of: SO_0000673
so part of: YHR074W
location: 246193..248337
location: region:246193-248337:1
so has part: feature:246193-248337:1:exon

NP_011941.1
type: Protein
SIO_000068: ncbiprotein

S000001116
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246193-248337:1:exon

YHR075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPE1
locus tag: YHR075C
so part of: sequence
location: complement(<248439..>249641)
location: region:248439-249641:-1
so has part: feature:248439-249641:-1:exon
subclass of: SO_0000010

856474
type: Gene
SIO_000068: ncbigene

position:248439:-1
position: 248439
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:249641:-1
position: 249641
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248439-249641:-1:exon

YHR075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPE1
locus tag: YHR075C
product: carboxylesterase-mitochondrial 37S ribosomal protein YmS2
transcript id: NM_001179205.1
SIO_010081: YHR075C
subclass of: SO_0000673
so part of: YHR075C
location: complement(<248439..>249641)
location: region:248439-249641:-1
so has part: feature:248439-249641:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248439-249641:-1:exon

YHR075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPE1
locus tag: YHR075C
EC number: 3.1.1.89
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9151978]
experiment: EXISTENCE:mutant phenotype:GO:0051722 protein C-terminal methylesterase activity [PMID:11060018]
experiment: EXISTENCE:mutant phenotype:GO:1990577 C-terminal protein demethylation [PMID:11060018]
note: Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
codon start: 1
product: carboxylesterase-mitochondrial 37S ribosomal protein YmS2
translation: MSDDLRRKIALSQFERAKNVLDATFQEAYEDDENDGDALGSLPSFNGQSNRNRKYTGKTGSTTDRISSKEKSSLPTWSDFFDNKELVSLPDRDLDVNTYYTLPTSLLSNTTSIPIFIFHHGAGSSGLSFANLAKELNTKLEGRCGCFAFDARGHAETKFKKADAPICFDRDSFIKDFVSLLNYWFKSKISQEPLQKVSVILIGHSLGGSICTFAYPKLSTELQKKILGITMLDIVEEAAIMALNKVEHFLQNTPNVFESINDAVDWHVQHALSRLRSSAEIAIPALFAPLKSGKVVRITNLKTFSPFWDTWFTDLSHSFVGLPVSKLLILAGNENLDKELIVGQMQGKYQLVVFQDSGHFIQEDSPIKTAITLIDFWKRNDSRNVVIKTNWGQHKTVQNT
SIO_010081: YHR075C
subclass of: SO_0000673
so part of: YHR075C
location: complement(248439..249641)
location: region:248439-249641:-1
so has part: feature:248439-249641:-1:exon

NP_011942.1
type: Protein
SIO_000068: ncbiprotein

S000001117
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248439-249641:-1:exon

YHR076W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTC7
locus tag: YHR076W
so part of: sequence
location: <251101..>252225
location: region:251101-252225:1
so has part: feature:251101-252225:1:exon
subclass of: SO_0000010

856475
type: Gene
SIO_000068: ncbigene

position:251101:1
position: 251101
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:252225:1
position: 252225
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251101-252225:1:exon

YHR076W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTC7
locus tag: YHR076W
product: type 2C protein phosphatase PTC7
transcript id: NM_001179206.1
SIO_010081: YHR076W
subclass of: SO_0000673
so part of: YHR076W
location: join(<251101..251155,251249..>252225)
location: region:251101-252225:1
so has part: feature:251101-251155:1:exon
so has part: feature:251249-252225:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251101-251155:1:exon

position:251155:1
position: 251155
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:251249-252225:1:exon

position:251249:1
position: 251249
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR076W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTC7
locus tag: YHR076W
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:23940037]
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:12220683|PMID:23940037]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:19564484]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11327310|PMID:18180296|PMID:19564484|PMID:14576278|P MID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:23940037]
note: Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p
codon start: 1
product: type 2C protein phosphatase PTC7
translation: MFANVGFRTLRVSRGPLYGSCSQIISFSKRTFYSSAKSGYQSNNSHGDAYSSGSQSGPFTYKTAVAFQPKDRDDLIYQKLKDSIRSPTGEDNYFVTSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHFPSNGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDITVVVVRVD
SIO_010081: YHR076W
subclass of: SO_0000673
so part of: YHR076W
location: join(251101..251155,251249..252225)
location: region:251101-252225:1
so has part: feature:251101-251155:1:exon
so has part: feature:251249-252225:1:exon

NP_011943.2
type: Protein
SIO_000068: ncbiprotein

S000001118
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251101-251155:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:251249-252225:1:exon

YHR077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IFS1
alternative label: SUA1
alternative label: SUP111
alternative label: UPF2
gene: NMD2
locus tag: YHR077C
gene synonym: IFS1; SUA1; SUP111; UPF2
so part of: sequence
location: complement(<252374..>255756)
location: region:252374-255756:-1
so has part: feature:252374-255756:-1:exon
subclass of: SO_0000010

856476
type: Gene
SIO_000068: ncbigene

position:252374:-1
position: 252374
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255756:-1
position: 255756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:252374-255756:-1:exon

YHR077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IFS1
alternative label: SUA1
alternative label: SUP111
alternative label: UPF2
gene: NMD2
locus tag: YHR077C
gene synonym: IFS1; SUA1; SUP111; UPF2
product: Nmd2p
transcript id: NM_001179207.1
SIO_010081: YHR077C
subclass of: SO_0000673
so part of: YHR077C
location: complement(join(<252374..255637,255751..>255756))
location: region:252374-255756:-1
so has part: feature:255751-255756:-1:exon
so has part: feature:252374-255637:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255751-255756:-1:exon

position:255751:-1
position: 255751
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:252374-255637:-1:exon

position:255637:-1
position: 255637
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IFS1
alternative label: SUA1
alternative label: SUP111
alternative label: UPF2
gene: NMD2
locus tag: YHR077C
gene synonym: IFS1; SUA1; SUP111; UPF2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16043493]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:9268361]
experiment: EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:16611983]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]
note: Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
codon start: 1
product: Nmd2p
translation: MDDGRKKELHDLNTRAWNGEEVFPLKSKKLDSSIKRNTGFIKKLKKGFVKGSESSLLKDLSEASLEKYLSEIIVTVTECLLNVLNKNDDVIAAVEIISGLHQRFNGRFTSPLLGAFLQAFENPSVDIESERDELQRITRVKGNLRVFTELYLVGVFRTLDDIESKDAIPNFLQKKTGRKDPLLFSILREILNYKFKLGFTTTIATAFIKKFAPLFRDDDNSWDDLIYDSKLKGALQSLFKNFIDATFARATELHKKVNKLQREHQKCQIRTGKLRDEYVEEYDKLLPIFIRFKTSAITLGEFFKLEIPELEGASNDDLKETASPMITNQILPPNQRLWENEDTRKFYEILPDISKTVEESQSSKTEKDSNVNSKNINLFFTDLEMADCKDIIDDLSNRYWSSYLDNKATRNRILKFFMETQDWSKLPVYSRFIATNSKYMPEIVSEFINYLDNGFRSQLHSNKINVKNIIFFSEMIKFQLIPSFMIFHKIRTLIMYMQVPNNVEILTVLLEHSGKFLLNKPEYKELMEKMVQLIKDKKNDRQLNMNMKSALENIITLLYPPSVKSLNVTVKTITPEQQFYRILIRSELSSLDFKHIVKLVRKAHWDDVAIQKVLFSLFSKPHKISYQNIPLLTKVLGGLYSYRRDFVIRCIDQVLENIERGLEINDYGQNMHRISNVRYLTEIFNFEMIKSDVLLDTIYHIIRFGHINNQPNPFYLNYSDPPDNYFRIQLVTTILLNINRTPAAFTKKCKLLLRFFEYYTFIKEQPLPKETEFRVSSTFKKYENIFGNTKFERSENLVESASRLESLLKSLNAIKSKDDRVKGSSASIHNGKESAVPIESITEDDEDEDDENDDGVDLLGEDEDAEISTPNTESAPGKHQAKQDESEDEDDEDDDEDDDDDDDDDDDDGEEGDEDDDEDDDDEDDDDEEEEDSDSDLEYGGDLDADRDIEMKRMYEEYERKLKDEEERKAEEELERQFQKMMQESIDARKSEKVVASKIPVISKPVSVQKPLLLKKSEEPSSSKETYEELSKPKKIAFTFLTKSGKKTQSRILQLPTDVKFVSDVLEEEEKLKTERNKIKKIVLKRSFD
SIO_010081: YHR077C
subclass of: SO_0000673
so part of: YHR077C
location: complement(join(252374..255637,255751..255756))
location: region:252374-255756:-1
so has part: feature:255751-255756:-1:exon
so has part: feature:252374-255637:-1:exon

NP_011944.2
type: Protein
SIO_000068: ncbiprotein

S000001119
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255751-255756:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:252374-255637:-1:exon

YHR078W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR078W
so part of: sequence
location: <256360..>258018
location: region:256360-258018:1
so has part: feature:256360-258018:1:exon
subclass of: SO_0000010

856477
type: Gene
SIO_000068: ncbigene

position:256360:1
position: 256360
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:258018:1
position: 258018
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256360-258018:1:exon

YHR078W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR078W
product: uncharacterized protein
transcript id: NM_001179208.1
SIO_010081: YHR078W
subclass of: SO_0000673
so part of: YHR078W
location: <256360..>258018
location: region:256360-258018:1
so has part: feature:256360-258018:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256360-258018:1:exon

YHR078W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR078W
note: High osmolarity-regulated gene of unknown function
codon start: 1
product: uncharacterized protein
translation: MEALIVFIVLSVSGAFAYKCSYERLWFKVGSLFDIISTSSKKNVIPLASKMEVGSNEDVSSMGNFINKFYTEYSLPSHKVLQSLRVLFSLAMMTYTVTIEIILWQIKVAGMDKEVTFITTWVWPLTAIMLSFILILFQPFFIIISLLNKFYNDKFDIDRLIIVTCIILSTLIALLSYINIGPFQYTKNILTRLSIGGVTVMASLSGLATVSSLYYNFLVIWHKFRNTPMSDPSFRNINNSNNNSKSLLWTTDAYIEEKIQDYEHNIEQNVQILRSLEEEVGENSTFKAELMEKIAWYQLELGKLEALLQQSPQVRTFKKAFEVGFIIYCLHKLIITFLKRIPYIIYHSLKYPDDYDYENFSENAASDPLAITIANILDFSFFRFNYQHDLDSLTKQISLFLSISLFLCCLSAVNTTISYVVTLLPIKFQILALFAMQNDDTANVLPEYTNNSSYKGKKRNYSQEQKGISLIKNLVVSELTGVYVLATTLMVRSHLPFEVSQRLKELLGGKFTVPNIVIDSWFDEVYAFACVFTFICIRIAERKLSTKKVSVE
SIO_010081: YHR078W
subclass of: SO_0000673
so part of: YHR078W
location: 256360..258018
location: region:256360-258018:1
so has part: feature:256360-258018:1:exon

NP_011945.1
type: Protein
SIO_000068: ncbiprotein

S000001120
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256360-258018:1:exon

YHR079C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ERN1
gene: IRE1
locus tag: YHR079C
gene synonym: ERN1
so part of: sequence
location: complement(<258244..>261591)
location: region:258244-261591:-1
so has part: feature:258244-261591:-1:exon
subclass of: SO_0000010

856478
type: Gene
SIO_000068: ncbigene

position:258244:-1
position: 258244
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:261591:-1
position: 261591
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:258244-261591:-1:exon

YHR079C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ERN1
gene: IRE1
locus tag: YHR079C
gene synonym: ERN1
product: bifunctional endoribonuclease/protein kinase IRE1
transcript id: NM_001179209.1
SIO_010081: YHR079C
subclass of: SO_0000673
so part of: YHR079C
location: complement(<258244..>261591)
location: region:258244-261591:-1
so has part: feature:258244-261591:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:258244-261591:-1:exon

YHR079C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ERN1
gene: IRE1
locus tag: YHR079C
gene synonym: ERN1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004521 endoribonuclease activity [PMID:9323131]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8663458]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17035634]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8358794]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:17923530]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]
experiment: EXISTENCE:mutant phenotype:GO:0006020 inositol metabolic process [PMID:1625574]
experiment: EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:8358794|PMID:8513503]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18971375|PMID:8898193]
experiment: EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233]
experiment: EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:17923530]
note: Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress
codon start: 1
product: bifunctional endoribonuclease/protein kinase IRE1
translation: MRLLRRNMLVLTLLVCVFSSIISCSIPLSSRTSRRQIVEDEVASTKKLNFNYGVDKNINSPIPAPRTTEGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISVPYLENRSLNELSLSDILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLIEIQEPSRLETYETLIIEPFGDGNIYYFNAHQGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPGSKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIHSYDGASYNVTYSTWQQNVLDVPLALQNTFSKDGMCIAPFRDKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLRTNENILVPHPFNPGDHESISSNKVYLDQTSNLSWFALSSQNFPSLVESAPISRYASSDRWRVSSIFEDETLFKNAIMGVHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVDTTDLHQNNEMNSLKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFKILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLKSEKDNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS
SIO_010081: YHR079C
subclass of: SO_0000673
so part of: YHR079C
location: complement(258244..261591)
location: region:258244-261591:-1
so has part: feature:258244-261591:-1:exon

NP_011946.1
type: Protein
SIO_000068: ncbiprotein

S000001121
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:258244-261591:-1:exon

YHR079C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YHR079C-B
gene: SAE3
locus tag: YHR079C-A
gene synonym: YHR079C-B
so part of: sequence
location: complement(<262192..>262553)
location: region:262192-262553:-1
so has part: feature:262192-262553:-1:exon
subclass of: SO_0000010

856479
type: Gene
SIO_000068: ncbigene

position:262192:-1
position: 262192
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:262553:-1
position: 262553
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:262192-262553:-1:exon

YHR079C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YHR079C-B
gene: SAE3
locus tag: YHR079C-A
gene synonym: YHR079C-B
product: Sae3p
transcript id: NM_001180026.1
SIO_010081: YHR079C-A
subclass of: SO_0000673
so part of: YHR079C-A
location: complement(join(<262192..262354,262441..>262553))
location: region:262192-262553:-1
so has part: feature:262441-262553:-1:exon
so has part: feature:262192-262354:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:262441-262553:-1:exon

position:262441:-1
position: 262441
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:262192-262354:-1:exon

position:262354:-1
position: 262354
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR079C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YHR079C-B
gene: SAE3
locus tag: YHR079C-A
gene synonym: YHR079C-B
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15579681|PMID:15620352]
experiment: EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:15579681|PMID:15620352]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:9215889]
note: Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
codon start: 1
product: Sae3p
translation: MNYLETQLNKKQKQIQEYESMNGNLIKMFEQLSKEKKNDETPKKISSTYIKELKEYNELRDAGLRLAQIIADEKQCKIKDVFEEIGYSMKD
SIO_010081: YHR079C-A
subclass of: SO_0000673
so part of: YHR079C-A
location: complement(join(262192..262354,262441..262553))
location: region:262192-262553:-1
so has part: feature:262441-262553:-1:exon
so has part: feature:262192-262354:-1:exon

NP_011947.2
type: Protein
SIO_000068: ncbiprotein

S000001957
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:262441-262553:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:262192-262354:-1:exon

YHR080C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LTC3
gene: LAM4
locus tag: YHR080C
gene synonym: LTC3
so part of: sequence
location: complement(<262801..>266838)
location: region:262801-266838:-1
so has part: feature:262801-266838:-1:exon
subclass of: SO_0000010

856480
type: Gene
SIO_000068: ncbigene

position:262801:-1
position: 262801
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:266838:-1
position: 266838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:262801-266838:-1:exon

YHR080C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LTC3
gene: LAM4
locus tag: YHR080C
gene synonym: LTC3
product: Lam4p
transcript id: NM_001179210.1
SIO_010081: YHR080C
subclass of: SO_0000673
so part of: YHR080C
location: complement(<262801..>266838)
location: region:262801-266838:-1
so has part: feature:262801-266838:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:262801-266838:-1:exon

YHR080C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LTC3
gene: LAM4
locus tag: YHR080C
gene synonym: LTC3
experiment: EXISTENCE:curator inference:GO:0032366 intracellular sterol transport [PMID:26001273]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]
experiment: EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:26001273]
experiment: EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29339490]
experiment: EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:33255682]
note: Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Lam4p
translation: MTRDSKKKHHWGTAFLRTIGVKRKHKKDRNFLNNTTGENVSTTASAERFRRVGGNPDIPSLLKPETFTESPAKGSQKAAASSLAHSQGVFNIPIVIDPMETNRLEKTNTNLTAGSLKGRFQDGNSNSNSVPSLSVQALEKEKLQSGKREGSSNQAEEKTPDGHDEHTAFETFLSFAHNAVSHIPKINVQDADNGTISRNEPKDRKKNSSNISGALSENSTNNKNTSSTKESDGPFLKNLDNILAASKSSTPSNQQLNTTEAGSKSKPSSLSRLAFGNLKGHIHSNSHSSSNAISGDDTSLDDTRKMTDDMARKVVFEPIRHSHDKPTPGVGNLKLEHFDDSQATLEGLEAMSAESLPEADHLDSRGPVQQSNLERKTVPSKWSVVSSSTTDGVKPRRRAKSMISAMADKQNTSSDVLQDCKKRLSFNSSNGLTNNDPEYEDREPREMSKKFLNRRSFSPGSISMGMKVLPSTALKYSLNKVKNSTDIASTIIPRPSMSNGRPSSGLRRSSSKSFSSTPVNIIEPSEENGRQSSIRIKGVEYASEKKDAEFHAIFKDSGVSPNERLILDHSCALSRDILLQGRMYISDQHIGFYSNILGWVSTVFIPFKTIVQIEKRATAGIFPNGIVIDTLHTKYTFASFTSRDATYDLITEVWNQIILGKRFRSNSNNTNSSSNSISDDENDDYDDDYDDYGDDDDDLYDNSNNISDSTDMTSSVSIGKPEDLPMPLQTDTPYGTGIPPLGPKIHSPTETVYKPAPNEKLVNESTIHASLGRVVNILFGKDVSYIMAILKAQKNSDISPIPVLVDSPTVSEGKKRDYSYVKTTPGAIGPGKTKCMITETIQHFNLEEYVQVLQTTKTPDVPSGNSFYVRTVYLLSWANNNETKLKLYVSVEWTGKSLIKSPIEKGTFDGVTDATKILVEELGNILTRSATKRKRSSKENTVTVSTLPKMEPSSHAPTEPDIQKDKDDSIIRENENIPAPLGTVVQLLFGSNTEYMQKVITRDKNNVNVETIPKFTPSLVEGGSRHYEYTKKLNNSIGPKQTKCLLTESIEHMDINNYVLVTQTTKTPDVPSGSNFAVESKIFLFWGQHDTTNMTVITKINWTSKSFLKGAIEKGSVEGQKVSVDYMLSELRDIISRAKSKKPVKKVMKSHDKHRPFHSKVEQKSSESRKSDDNKDILTHILDFVQNNFSSEIFMNKLLSPQKLFLILGLTIMLFWSPRLHVFQEKNNLQIIKPGRLLIDGQEYNYVPSFGTLYNSYENAISSKKKRENVNYARDKSPIVGRESDIWDWISNRGSAISPRGRAMLRNDDEHKLQQLSESIKITEMQLNHMKTMLDNIERDANDLS
SIO_010081: YHR080C
subclass of: SO_0000673
so part of: YHR080C
location: complement(262801..266838)
location: region:262801-266838:-1
so has part: feature:262801-266838:-1:exon

NP_011948.1
type: Protein
SIO_000068: ncbiprotein

S000001122
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:262801-266838:-1:exon

YHR081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RRP47
gene: LRP1
locus tag: YHR081W
gene synonym: RRP47
so part of: sequence
location: <267538..>268092
location: region:267538-268092:1
so has part: feature:267538-268092:1:exon
subclass of: SO_0000010

856481
type: Gene
SIO_000068: ncbigene

position:267538:1
position: 267538
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:268092:1
position: 268092
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267538-268092:1:exon

YHR081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RRP47
gene: LRP1
locus tag: YHR081W
gene synonym: RRP47
product: Lrp1p
transcript id: NM_001179211.1
SIO_010081: YHR081W
subclass of: SO_0000673
so part of: YHR081W
location: <267538..>268092
location: region:267538-268092:1
so has part: feature:267538-268092:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267538-268092:1:exon

YHR081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RRP47
gene: LRP1
locus tag: YHR081W
gene synonym: RRP47
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:17704127]
experiment: EXISTENCE:direct assay:GO:0003725 double-stranded RNA binding [PMID:17704127]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23580640]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:24937447]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:12837249|PMID:19046973]
experiment: EXISTENCE:direct assay:GO:1901917 regulation of exoribonuclease activity [PMID:24937447]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:17410208]
experiment: EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18591258]
experiment: EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]
experiment: EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12972615]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18614049]
experiment: EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:12972615]
experiment: EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:12972615]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:16652390]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:12972615]
experiment: EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:16973436|PMID:18591258]
experiment: EXISTENCE:mutant phenotype:GO:0071051 polyadenylation-dependent snoRNA 3'-end processing [PMID:12972615]
note: Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
codon start: 1
product: Lrp1p
translation: MEDIEKIKPYVRSFSKALDELKPEIEKLTSKSLDEQLLLLSDERAKLELINRYAYVLSSLMFANMKVLGVKDMSPILGELKRVKSYMDKAKQYDNRITKSNEKSQAEQEKAKNIISNVLDGNKNQFEPSISRSNFQGKHTKFENDELAESTTTKIIDSTDHIRKASSKKSKRLDKVGKKKGGKK
SIO_010081: YHR081W
subclass of: SO_0000673
so part of: YHR081W
location: 267538..268092
location: region:267538-268092:1
so has part: feature:267538-268092:1:exon

NP_011949.1
type: Protein
SIO_000068: ncbiprotein

S000001123
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267538-268092:1:exon

YHR082C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KSP1
locus tag: YHR082C
so part of: sequence
location: complement(<268459..>271548)
location: region:268459-271548:-1
so has part: feature:268459-271548:-1:exon
subclass of: SO_0000010

856482
type: Gene
SIO_000068: ncbigene

position:268459:-1
position: 268459
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271548:-1
position: 271548
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:268459-271548:-1:exon

YHR082C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KSP1
locus tag: YHR082C
product: putative serine/threonine protein kinase KSP1
transcript id: NM_001179212.1
SIO_010081: YHR082C
subclass of: SO_0000673
so part of: YHR082C
location: complement(<268459..>271548)
location: region:268459-271548:-1
so has part: feature:268459-271548:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:268459-271548:-1:exon

YHR082C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KSP1
locus tag: YHR082C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:8676864]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18417610|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]
experiment: EXISTENCE:genetic interaction:GO:0016242 negative regulation of macroautophagy [PMID:22447937]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:18417610]
experiment: EXISTENCE:mutant phenotype:GO:0010570 regulation of filamentous growth [PMID:18417610]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:22447937]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:22043304]
experiment: EXISTENCE:mutant phenotype:GO:0043555 regulation of translation in response to stress [PMID:31455721]
experiment: EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304|PMID:31455721]
experiment: EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:22043304]
note: Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative serine/threonine protein kinase KSP1
translation: MTLDYEIYKEGGILNNRYQKIEDISEGSYGYVSLAKDVREKRLVAVKYIFKLEDDGQYDGPQDDENDCDSSDCDDDEDTKVDTDRHENENGNASSNNGSSREKKHNLYKHKKSLISSKVKSRLSNNICLEAMYEVDIQTKIGRHQNIAALLDFFDSYIIMEYCSGGDLYEAIKADAVPKKTKSITHIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLATTDKTSMDRNVGSERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYFAANREALFDVFSTMAYDFFQVLRYSLTIDPANRDLKMMRTELQNLSEYTLDDEYYNNLDEGYEETMIDGLPPQPVPPSSAPVSLPTPISSSNKQHMPEFKKDFNFNNVNERKRSDVSQNQNVASGFFKKPSTQQQKFFNQGYNTTLSTHERAKSAPKFKFKKRNKYGRTDNQFSKPVNIEDRKKSKILKKSRKPLGIPTPNTHMNNFFHDYKARDEFNTRDFFTPPSVQHRYMEGFSNNNNKQYRQNRNYNNNNNNSNNNHGSNYNNFNNGNSYIKGWNKNFNKYRRPSSSSYTGKSPLSRYNMSYNHNNNSSINGYARRGSTTTVQHSPGAYIPPNARNHHVSPTNQFLRVPQSTAPDISTVLGGKPSYQEHYTQDSMDSEGDHDSDDVLFTLEEGDHDFVNGMDNLSINDHLPHTTVGSHNEVFVHASTNHNNNGNNNHIDTNSTTNQYHRQYIPPPLTTSLHINNNNNESNELPDLLKSPASSEAHLNLSSGPIDPILTGNIGNRYSHSSDSKELEQERRLSMEQKFKNGVYVPPHHRKSFNLGTQVPPMNMKTSNEATLSVSHNSVNFGGSYNSRRSSANESNPLHMNKALEKLSSSPGAKSSFVGFPKPLLPRNHSSTTIALQNEDVFADSNNDAIIFEDEEYEGESDKMAHGKMEGGDNESSSTSPDERQIFGPYEIYAQTFAGSTHDKKLGAGRKTSIQDEMVGSLEQYKNNWLILQQQD
SIO_010081: YHR082C
subclass of: SO_0000673
so part of: YHR082C
location: complement(268459..271548)
location: region:268459-271548:-1
so has part: feature:268459-271548:-1:exon

NP_011950.1
type: Protein
SIO_000068: ncbiprotein

S000001124
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:268459-271548:-1:exon

YHR083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP20
alternative label: TOB38
alternative label: TOM38
gene: SAM35
locus tag: YHR083W
gene synonym: FMP20; TOB38; TOM38
so part of: sequence
location: <272627..>273616
location: region:272627-273616:1
so has part: feature:272627-273616:1:exon
subclass of: SO_0000010

856483
type: Gene
SIO_000068: ncbigene

position:272627:1
position: 272627
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273616:1
position: 273616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272627-273616:1:exon

YHR083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP20
alternative label: TOB38
alternative label: TOM38
gene: SAM35
locus tag: YHR083W
gene synonym: FMP20; TOB38; TOM38
product: SAM complex subunit SAM35
transcript id: NM_001179213.1
SIO_010081: YHR083W
subclass of: SO_0000673
so part of: YHR083W
location: <272627..>273616
location: region:272627-273616:1
so has part: feature:272627-273616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272627-273616:1:exon

YHR083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP20
alternative label: TOB38
alternative label: TOM38
gene: SAM35
locus tag: YHR083W
gene synonym: FMP20; TOB38; TOM38
experiment: EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:15067005|PMID:15205677]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15067005|PMID:16407407|PMID:15205677]
experiment: EXISTENCE:mutant phenotype:GO:0001401 SAM complex [PMID:15205677]
experiment: EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:15326197|PMID:18039934|PMID:15067005]
experiment: EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:15067005|PMID:15205677|PMID:18039934]
note: Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
codon start: 1
product: SAM complex subunit SAM35
translation: MVSSFSVPMPVKRIFDTFPLQTYAAQTDKDEAVALEIQRRSYTFTERGGGSSELTVEGTYKLGVYNVFLEANTGAALATDPWCLFVQLALCQKNGLVLPTHSQEQTPSHTCNHEMLVLSRLSNPDEALPILVEGYKKRIIRSTVAISEIMRSRILDDAEQLMYYTLLDTVLYDCWITQIIFCASDAQFMELYSCQKLSGSIVTPLDVENSLLQKLSAKSLKISLTKRNKFQFRHREIVKSMQGVYHNHHNSVNQEQVLNVLFENSKQVLLGLKDMLKSDGQPTYLHLKIASYILCITNVKEPIKLKTFVENECKELVQFAQDTLKNFVQ
SIO_010081: YHR083W
subclass of: SO_0000673
so part of: YHR083W
location: 272627..273616
location: region:272627-273616:1
so has part: feature:272627-273616:1:exon

NP_011951.1
type: Protein
SIO_000068: ncbiprotein

S000001125
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272627-273616:1:exon

YHR084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STE12
locus tag: YHR084W
so part of: sequence
location: <274174..>276240
location: region:274174-276240:1
so has part: feature:274174-276240:1:exon
subclass of: SO_0000010

856484
type: Gene
SIO_000068: ncbigene

position:274174:1
position: 274174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276240:1
position: 276240
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274174-276240:1:exon

YHR084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STE12
locus tag: YHR084W
product: homeodomain family transcription factor STE12
transcript id: NM_001179214.1
SIO_010081: YHR084W
subclass of: SO_0000673
so part of: YHR084W
location: <274174..>276240
location: region:274174-276240:1
so has part: feature:274174-276240:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274174-276240:1:exon

YHR084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STE12
locus tag: YHR084W
experiment: EXISTENCE:direct assay:GO:0000747 conjugation with cellular fusion [PMID:3931921]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:2558054]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19159085]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:20852627]
experiment: EXISTENCE:direct assay:GO:1990526 Ste12p-Dig1p-Dig2p complex [PMID:16782869]
experiment: EXISTENCE:direct assay:GO:1990527 Tec1p-Ste12p-Dig1p complex [PMID:16782869]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16940175]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8259520|PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7834739]
note: Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
codon start: 1
product: homeodomain family transcription factor STE12
translation: MKVQITNSRTEEILKVQANNENDEVSKATPGEVEESLRLIGDLKFFLATAPVNWQENQIIRRYYLNSGQGFVSCVFWNNLYYITGTDIVKCCLYRMQKFGREVVQKKKFEEGIFSDLRNLKCGIDATLEQPKSEFLSFLFRNMCLKTQKKQKVFFWFSVAHDKLFADALERDLKRESLNQPSTTKPVNEPALSFSYDSSSDKPLYDQLLQHLDSRRPSSTTKSDNSPPKLESENFKDNELVTVTNQPLLGVGLMDDDAPESPSQINDFIPQKLIIEPNTLELNGLTEETPHDLPKNTAKGRDEEDFPLDYFPVSVEYPTEENAFDPFPPQAFTPAAPSMPISYDNVNERDSMPVNSLLNRYPYQLSVAPTFPVPPSSSRQHFMTNRDFYSSNNNKEKLVSPSDPTSYMKYDEPVMDFDESRPNENCTNAKSHNSGQQTKQHQLYSNNFQQSYPNGMVPGYYPKMPYNPMGGDPLLDQAFYGADDFFFPPEGCDNNMLYPQTATSWNVLPPQAMQPAPTYVGRPYTPNYRSTPGSAMFPYMQSSNSMQWNTAVSPYSSRAPSTTAKNYPPSTFYSQNINQYPRRRTVGMKSSQGNVPTGNKQSVGKSAKISKPLHIKTSAYQKQYKINLETKARPSAGDEDSAHPDKNKEISMPTPDSNTLVVQSEEGGAHSLEVDTNRRSDKNLPDAT
SIO_010081: YHR084W
subclass of: SO_0000673
so part of: YHR084W
location: 274174..276240
location: region:274174-276240:1
so has part: feature:274174-276240:1:exon

NP_011952.1
type: Protein
SIO_000068: ncbiprotein

S000001126
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274174-276240:1:exon

YHR085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IPI1
locus tag: YHR085W
so part of: sequence
location: <276764..>277768
location: region:276764-277768:1
so has part: feature:276764-277768:1:exon
subclass of: SO_0000010

856485
type: Gene
SIO_000068: ncbigene

position:276764:1
position: 276764
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:277768:1
position: 277768
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276764-277768:1:exon

YHR085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IPI1
locus tag: YHR085W
product: Ipi1p
transcript id: NM_001179215.1
SIO_010081: YHR085W
subclass of: SO_0000673
so part of: YHR085W
location: <276764..>277768
location: region:276764-277768:1
so has part: feature:276764-277768:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:276764-277768:1:exon

YHR085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IPI1
locus tag: YHR085W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0097344 Rix1 complex [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]
experiment: EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]
note: Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene
codon start: 1
product: Ipi1p
translation: MTKSRKQKQKKQDFLRKKLKVGKPKEKARNATDTSFVSKTISIRNQHLDQNPHDLTKRLTLLKHHNINVRKETLTTFQKSIPSIIKSRLMTPLLTQSIPLICDESQQVRQGLIDLVDEIGSHDAEILKLHCNIFVLYINMAMTHIVTQIQADSTKFLSHLLKYCGDEVVRKSWVKLLNGVFGVLGWGQVGKNDSASIVQTKKRNAKYVTIHLNALYTLVEYGCQDERARSDGDTAETTEDSGTLRNPYLIPDYPQPFEHLKLFTRELKVQDATSSGVNATLLSLATQDIDTRKAVFIEQFLPIVRKKIEVIIKEGGECGKSANKLKTLLAKIFD
SIO_010081: YHR085W
subclass of: SO_0000673
so part of: YHR085W
location: 276764..277768
location: region:276764-277768:1
so has part: feature:276764-277768:1:exon

NP_011953.1
type: Protein
SIO_000068: ncbiprotein

S000001127
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:276764-277768:1:exon

YHR086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MRE2
alternative label: MUD15
gene: NAM8
locus tag: YHR086W
gene synonym: MRE2; MUD15
so part of: sequence
location: <278153..>279724
location: region:278153-279724:1
so has part: feature:278153-279724:1:exon
subclass of: SO_0000010

856486
type: Gene
SIO_000068: ncbigene

position:278153:1
position: 278153
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:279724:1
position: 279724
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278153-279724:1:exon

YHR086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MRE2
alternative label: MUD15
gene: NAM8
locus tag: YHR086W
gene synonym: MRE2; MUD15
product: Nam8p
transcript id: NM_001179216.1
SIO_010081: YHR086W
subclass of: SO_0000673
so part of: YHR086W
location: <278153..>279724
location: region:278153-279724:1
so has part: feature:278153-279724:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278153-279724:1:exon

YHR086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MRE2
alternative label: MUD15
gene: NAM8
locus tag: YHR086W
gene synonym: MRE2; MUD15
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
experiment: EXISTENCE:mutant phenotype:GO:0006376 mRNA splice site selection [PMID:10072385]
experiment: EXISTENCE:mutant phenotype:GO:0048026 positive regulation of mRNA splicing, via spliceosome [PMID:10983980]
experiment: EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]
experiment: EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]
note: RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
codon start: 1
product: Nam8p
translation: MSYKQTTYYPSRGNLVRNDSSPYTNTISSETNNSSTSVLSLQGASNVSLGTTGNQLYMGDLDPTWDKNTVRQIWASLGEANINVRMMWNNTLNNGSRSSMGPKNNQGYCFVDFPSSTHAANALLKNGMLIPNFPNKKLKLNWATSSYSNSNNSLNNVKSGNNCSIFVGDLAPNVTESQLFELFINRYASTSHAKIVHDQVTGMSKGYGFVKFTNSDEQQLALSEMQGVFLNGRAIKVGPTSGQQQHVSGNNDYNRSSSSLNNENVDSRFLSKGQSFLSNGNNNMGFKRNHMSQFIYPVQQQPSLNHFTDPNNTTVFIGGLSSLVTEDELRAYFQPFGTIVYVKIPVGKCCGFVQYVDRLSAEAAIAGMQGFPIANSRVRLSWGRSAKQTALLQQAMLSNSLQVQQQQPGLQQPNYGYIPSSTCEAPVLPDNNVSSTMLPGCQILNYSNPYANANGLGSNNFSFYSNNNATNTQATSLLADTSSMDLSGTGGQQVIMQGSEAVVNSTNAMLNRLEQGSNGFMFA
SIO_010081: YHR086W
subclass of: SO_0000673
so part of: YHR086W
location: 278153..279724
location: region:278153-279724:1
so has part: feature:278153-279724:1:exon

NP_011954.1
type: Protein
SIO_000068: ncbiprotein

S000001128
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278153-279724:1:exon

YHR086W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR086W-A
so part of: sequence
location: <280231..>280392
location: region:280231-280392:1
so has part: feature:280231-280392:1:exon
subclass of: SO_0000010

1466529
type: Gene
SIO_000068: ncbigene

position:280231:1
position: 280231
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280392:1
position: 280392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280231-280392:1:exon

YHR086W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR086W-A
product: uncharacterized protein
transcript id: NM_001184553.1
SIO_010081: YHR086W-A
subclass of: SO_0000673
so part of: YHR086W-A
location: <280231..>280392
location: region:280231-280392:1
so has part: feature:280231-280392:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280231-280392:1:exon

YHR086W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR086W-A
note: hypothetical protein; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively
codon start: 1
product: uncharacterized protein
translation: MRLSLYSCCLCIGARRIPTPCLFSYIFTPNLAHFHSPLRSSGFRPAGATRFYS
SIO_010081: YHR086W-A
subclass of: SO_0000673
so part of: YHR086W-A
location: 280231..280392
location: region:280231-280392:1
so has part: feature:280231-280392:1:exon

NP_878089.1
type: Protein
SIO_000068: ncbiprotein

S000028552
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280231-280392:1:exon

YHR087W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HGI1
gene: RTC3
locus tag: YHR087W
gene synonym: HGI1
so part of: sequence
location: <280820..>281155
location: region:280820-281155:1
so has part: feature:280820-281155:1:exon
subclass of: SO_0000010

856487
type: Gene
SIO_000068: ncbigene

position:280820:1
position: 280820
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281155:1
position: 281155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280820-281155:1:exon

YHR087W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HGI1
gene: RTC3
locus tag: YHR087W
gene synonym: HGI1
product: Rtc3p
transcript id: NM_001179217.1
SIO_010081: YHR087W
subclass of: SO_0000673
so part of: YHR087W
location: <280820..>281155
location: region:280820-281155:1
so has part: feature:280820-281155:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280820-281155:1:exon

YHR087W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HGI1
gene: RTC3
locus tag: YHR087W
gene synonym: HGI1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0016070 RNA metabolic process [PMID:15701634]
note: hypothetical protein involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
codon start: 1
product: Rtc3p
translation: MSTVTKYFYKGENTDLIVFAASEELVDEYLKNPSIGKLSEVVELFEVFTPQDGRGAEGELGAASKAQVENEFGKGKKIEEVIDLILRNGKPNSTTSSLKTKGGNAGTKAYN
SIO_010081: YHR087W
subclass of: SO_0000673
so part of: YHR087W
location: 280820..281155
location: region:280820-281155:1
so has part: feature:280820-281155:1:exon

NP_011955.1
type: Protein
SIO_000068: ncbiprotein

S000001129
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280820-281155:1:exon

YHR088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPF1
locus tag: YHR088W
so part of: sequence
location: <281495..>282382
location: region:281495-282382:1
so has part: feature:281495-282382:1:exon
subclass of: SO_0000010

856488
type: Gene
SIO_000068: ncbigene

position:281495:1
position: 281495
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:282382:1
position: 282382
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281495-282382:1:exon

YHR088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPF1
locus tag: YHR088W
product: rRNA-binding ribosome biosynthesis protein RPF1
transcript id: NM_001179218.1
SIO_010081: YHR088W
subclass of: SO_0000673
so part of: YHR088W
location: <281495..>282382
location: region:281495-282382:1
so has part: feature:281495-282382:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281495-282382:1:exon

YHR088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPF1
locus tag: YHR088W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11864606]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16581791]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]
note: Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
codon start: 1
product: rRNA-binding ribosome biosynthesis protein RPF1
translation: MALGNEINITNKLKRQEIFADIKHEKNKERHTMRRKRAKEERENPELREQRLKENVTQTIENTRVYDETINKEVEGDEDDLMRYFNSNSNEPPKIFLTTNVNAKKSAYEFANILIEILPNVTFVKRKFGYKLKEISDICIKRNFTDIVIINEDKKKVTGLTFIHLPEGPTFYFKLSSFVEVKKIVGHGRPTSHIPELILNNFQTRLGQTVGRLFQSILPQNPDIEGRQVITLHNQRDYIFFRRHRYVFKDNERVGLQELGPQFTLKLKRLQRGIKEETEWEHKPEMDKEKKKFYL
SIO_010081: YHR088W
subclass of: SO_0000673
so part of: YHR088W
location: 281495..282382
location: region:281495-282382:1
so has part: feature:281495-282382:1:exon

NP_011956.1
type: Protein
SIO_000068: ncbiprotein

S000001130
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281495-282382:1:exon

YHR089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GAR1
locus tag: YHR089C
so part of: sequence
location: complement(<282681..>283298)
location: region:282681-283298:-1
so has part: feature:282681-283298:-1:exon
subclass of: SO_0000010

856489
type: Gene
SIO_000068: ncbigene

position:282681:-1
position: 282681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283298:-1
position: 283298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282681-283298:-1:exon

YHR089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GAR1
locus tag: YHR089C
product: H/ACA snoRNP pseudouridylase subunit GAR1
transcript id: NM_001179219.1
SIO_010081: YHR089C
subclass of: SO_0000673
so part of: YHR089C
location: complement(<282681..>283298)
location: region:282681-283298:-1
so has part: feature:282681-283298:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282681-283298:-1:exon

YHR089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GAR1
locus tag: YHR089C
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:1531632|PMID:9843512]
experiment: EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:2898766]
experiment: EXISTENCE:physical interaction:GO:0034513 box H/ACA snoRNA binding [PMID:9556561]
note: Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA
codon start: 1
product: H/ACA snoRNP pseudouridylase subunit GAR1
translation: MSFRGGNRGGRGGFRGGFRGGRTGSARSFQQGPPDTVLEMGAFLHPCEGDIVCRSINTKIPYFNAPIYLENKTQVGKVDEILGPLNEVFFTIKCGDGVQATSFKEGDKFYIAADKLLPIERFLPKPKVVGPPKPKNKKKRSGAPGGRGGASMGRGGSRGGFRGGRGGSSFRGGRGGSSFRGGSRGGSFRGGSRGGSRGGFRGGRR
SIO_010081: YHR089C
subclass of: SO_0000673
so part of: YHR089C
location: complement(282681..283298)
location: region:282681-283298:-1
so has part: feature:282681-283298:-1:exon

NP_011957.1
type: Protein
SIO_000068: ncbiprotein

S000001131
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282681-283298:-1:exon

YHR090C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EAF4
alternative label: NBN1
gene: YNG2
locus tag: YHR090C
gene synonym: EAF4; NBN1
so part of: sequence
location: complement(<283777..>284625)
location: region:283777-284625:-1
so has part: feature:283777-284625:-1:exon
subclass of: SO_0000010

856490
type: Gene
SIO_000068: ncbigene

position:283777:-1
position: 283777
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:284625:-1
position: 284625
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:283777-284625:-1:exon

YHR090C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EAF4
alternative label: NBN1
gene: YNG2
locus tag: YHR090C
gene synonym: EAF4; NBN1
product: histone acetyltransferase YNG2
transcript id: NM_001179220.1
SIO_010081: YHR090C
subclass of: SO_0000673
so part of: YHR090C
location: complement(<283777..>284625)
location: region:283777-284625:-1
so has part: feature:283777-284625:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:283777-284625:-1:exon

YHR090C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EAF4
alternative label: NBN1
gene: YNG2
locus tag: YHR090C
gene synonym: EAF4; NBN1
experiment: EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:17274630]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10805724|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0032777 Piccolo NuA4 histone acetyltransferase complex [PMID:12782659]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]
note: Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5
codon start: 1
product: histone acetyltransferase YNG2
translation: MDPSLVLEQTIQDVSNLPSEFRYLLEEIGSNDLKLIEEKKKYEQKESQIHKFIRQQGSIPKHPQEDGLDKEIKESLLKCQSLQREKCVLANTALFLIARHLNKLEKNIALLEEDGVLAPVEEDGDMDSAAEASRESSVVSNSSVKKRRAASSSGSVPPTLKKKKTSRTSKLQNEIDVSSREKSVTPVSPSIEKKIARTKEFKNSRNGKGQNGSPENEEEDKTLYCFCQRVSFGEMVACDGPNCKYEWFHYDCVNLKEPPKGTWYCPECKIEMEKNKLKRKRN
SIO_010081: YHR090C
subclass of: SO_0000673
so part of: YHR090C
location: complement(283777..284625)
location: region:283777-284625:-1
so has part: feature:283777-284625:-1:exon

NP_011958.1
type: Protein
SIO_000068: ncbiprotein

S000001132
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:283777-284625:-1:exon

YHR091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSR1
locus tag: YHR091C
so part of: sequence
location: complement(<284839..>286770)
location: region:284839-286770:-1
so has part: feature:284839-286770:-1:exon
subclass of: SO_0000010

856491
type: Gene
SIO_000068: ncbigene

position:284839:-1
position: 284839
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286770:-1
position: 286770
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284839-286770:-1:exon

YHR091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSR1
locus tag: YHR091C
product: arginine--tRNA ligase MSR1
transcript id: NM_001179221.1
SIO_010081: YHR091C
subclass of: SO_0000673
so part of: YHR091C
location: complement(<284839..>286770)
location: region:284839-286770:-1
so has part: feature:284839-286770:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:284839-286770:-1:exon

YHR091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSR1
locus tag: YHR091C
EC number: 6.1.1.19
experiment: EXISTENCE:curator inference:GO:0070144 mitochondrial arginyl-tRNA aminoacylation [PMID:7607232]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]
note: Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication
codon start: 1
product: arginine--tRNA ligase MSR1
translation: MFGIVYLKNRSLLCKNPFSSYPRYGFMPSFDTQFSNQFRKLEINIGRKRYSSKTLNTKYTDQPEGPIYPLDVLRLDISKALHDISGIDHSLILNALESTNSMDRGDLLLPLPKIKVADPVAVANRWAIELSTHGCIGKVCAKGPFLQFFLDQRYLIQSTVPNILLQKGKYGQKKSRHQKKVVVEFSSPNIAKPFHAGHLRSTIIGGFLSNLYEAMGWSVTRMNYLGDWGRQFGLLAVGFKRYGDEKTLQKQPIQHLFDVYVKINMDLAKEEINGNSKCGISGEARSFFKNLENGDENAIKIWNRFRSLSIHHYIQTYSRLNINFDIFSGESQVSKESMNEALDIFRKNNLVKEIDGALVIDLTQWSKRLGRVVVQKSDGTTLYLTRDVGAAIERKKNLHFDKMVYVISSQQDLYMSQFFMILKKMNFEWAKDLQHINFGMVQGMSTRKGNVVFLDTILDEARDKALQIMENNKMKISQVDNPQRVADLIGVSAIIIQDMKSKRINNYEFNWNRMLSFEGDTGPYLQYTHSRLRSLERTSSDFTTDMLIHADFSNLNEPQLVELVRLLAQYPDVLRRAFETQEPATIVTYLFKVCHQVSSCYKKIWVSGKPADIAIPRLAVYSASRQVLHNAMSLLGLVPVDRM
SIO_010081: YHR091C
subclass of: SO_0000673
so part of: YHR091C
location: complement(284839..286770)
location: region:284839-286770:-1
so has part: feature:284839-286770:-1:exon

NP_011959.1
type: Protein
SIO_000068: ncbiprotein

S000001133
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:284839-286770:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS814; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 286770..287128
location: region:286770-287128:1
so has part: feature:286770-287128:1:region

S000130149
type: SGD
SIO_000068: sgd

position:286770:1
position: 286770
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:287128:1
position: 287128
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:286770-287128:1:region

YHR092C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LGT1
alternative label: RAG1
gene: HXT4
locus tag: YHR092C
gene synonym: LGT1; RAG1
so part of: sequence
location: complement(<287081..>288811)
location: region:287081-288811:-1
so has part: feature:287081-288811:-1:exon
subclass of: SO_0000010

856492
type: Gene
SIO_000068: ncbigene

position:287081:-1
position: 287081
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:288811:-1
position: 288811
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287081-288811:-1:exon

YHR092C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LGT1
alternative label: RAG1
gene: HXT4
locus tag: YHR092C
gene synonym: LGT1; RAG1
product: hexose transporter HXT4
transcript id: NM_001179222.2
SIO_010081: YHR092C
subclass of: SO_0000673
so part of: YHR092C
location: complement(<287081..>288811)
location: region:287081-288811:-1
so has part: feature:287081-288811:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:287081-288811:-1:exon

YHR092C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LGT1
alternative label: RAG1
gene: HXT4
locus tag: YHR092C
gene synonym: LGT1; RAG1
experiment: EXISTENCE:direct assay:GO:0005355 glucose transmembrane transporter activity [PMID:12702270]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17507646|PMID:24124599]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]
note: High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication
codon start: 1
product: hexose transporter HXT4
translation: MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK
SIO_010081: YHR092C
subclass of: SO_0000673
so part of: YHR092C
location: complement(287081..288811)
location: region:287081-288811:-1
so has part: feature:287081-288811:-1:exon

NP_011960.2
type: Protein
SIO_000068: ncbiprotein

S000001134
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:287081-288811:-1:exon

YHR093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AHT1
locus tag: YHR093W
so part of: sequence
location: <289142..>289690
location: region:289142-289690:1
so has part: feature:289142-289690:1:exon
subclass of: SO_0000010

856493
type: Gene
SIO_000068: ncbigene

position:289142:1
position: 289142
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:289690:1
position: 289690
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:289142-289690:1:exon

YHR093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AHT1
locus tag: YHR093W
product: Aht1p
transcript id: NM_001348818.1
SIO_010081: YHR093W
subclass of: SO_0000673
so part of: YHR093W
location: <289142..>289690
location: region:289142-289690:1
so has part: feature:289142-289690:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:289142-289690:1:exon

YHR093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AHT1
locus tag: YHR093W
note: hypothetical protein; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
codon start: 1
product: Aht1p
translation: MDCKIKAAGKNSGIFHEGGTKSSKSFLTVFIRSVFPLSPSFPAGGGIWGPMEKKPGGVGKKKGSEKKTAQGNIFFSTERDAGQEKCGILYKHCFSILYGFFWKKADKPKEKTGNGSGLGIVFPIGQKKIPEPADSDIFLPCFRYAAASDFTKAKRFLVEITAVYWVSLEAQPSSASCLFILI
SIO_010081: YHR093W
subclass of: SO_0000673
so part of: YHR093W
location: 289142..289690
location: region:289142-289690:1
so has part: feature:289142-289690:1:exon

NP_001335739.1
type: Protein
SIO_000068: ncbiprotein

S000001135
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:289142-289690:1:exon

YHR094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HOR4
gene: HXT1
locus tag: YHR094C
gene synonym: HOR4
so part of: sequence
location: complement(<290913..>292625)
location: region:290913-292625:-1
so has part: feature:290913-292625:-1:exon
subclass of: SO_0000010

856494
type: Gene
SIO_000068: ncbigene

position:290913:-1
position: 290913
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292625:-1
position: 292625
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290913-292625:-1:exon

YHR094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HOR4
gene: HXT1
locus tag: YHR094C
gene synonym: HOR4
product: hexose transporter HXT1
transcript id: NM_001179224.1
SIO_010081: YHR094C
subclass of: SO_0000673
so part of: YHR094C
location: complement(<290913..>292625)
location: region:290913-292625:-1
so has part: feature:290913-292625:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:290913-292625:-1:exon

YHR094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HOR4
gene: HXT1
locus tag: YHR094C
gene synonym: HOR4
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10377429|PMID:24124599]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:7651133]
experiment: EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]
experiment: EXISTENCE:mutant phenotype:GO:0015761 mannose transmembrane transport [PMID:2046678]
experiment: EXISTENCE:mutant phenotype:GO:1904659 glucose transmembrane transport [PMID:2046678]
note: Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
codon start: 1
product: hexose transporter HXT1
translation: MNSTPDLISPQKSNSSNSYELESGRSKAMNTPEGKNESFHDNLSESQVQPAVAPPNTGKGVYVTVSICCVMVAFGGFIFGWDTGTISGFVAQTDFLRRFGMKHHDGSHYLSKVRTGLIVSIFNIGCAIGGIVLAKLGDMYGRRIGLIVVVVIYTIGIIIQIASINKWYQYFIGRIISGLGVGGITVLSPMLISEVAPSEMRGTLVSCYQVMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMMFVPESPRYLVEAGRIDEARASLAKVNKCPPDHPYIQYELETIEASVEEMRAAGTASWGELFTGKPAMFQRTMMGIMIQSLQQLTGDNYFFYYGTIVFQAVGLSDSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLMWGAVGMVCCYVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIAYVVISECFPLRVKSKCMSIASAANWIWGFLISFFTPFITGAINFYYGYVFMGCMVFAYFYVFFFVPETKGLSLEEVNDMYAEGVLPWKSASWVPVSKRGADYNADDLMHDDQPFYKSLFSRK
SIO_010081: YHR094C
subclass of: SO_0000673
so part of: YHR094C
location: complement(290913..292625)
location: region:290913-292625:-1
so has part: feature:290913-292625:-1:exon

NP_011962.1
type: Protein
SIO_000068: ncbiprotein

S000001136
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:290913-292625:-1:exon

YHR096C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HXT5
locus tag: YHR096C
so part of: sequence
location: complement(<294669..>296447)
location: region:294669-296447:-1
so has part: feature:294669-296447:-1:exon
subclass of: SO_0000010

856496
type: Gene
SIO_000068: ncbigene

position:294669:-1
position: 294669
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:296447:-1
position: 296447
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:294669-296447:-1:exon

YHR096C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HXT5
locus tag: YHR096C
product: hexose transporter HXT5
transcript id: NM_001179226.1
SIO_010081: YHR096C
subclass of: SO_0000673
so part of: YHR096C
location: complement(<294669..>296447)
location: region:294669-296447:-1
so has part: feature:294669-296447:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:294669-296447:-1:exon

YHR096C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HXT5
locus tag: YHR096C
experiment: EXISTENCE:direct assay:GO:0005355 glucose transmembrane transporter activity [PMID:12702270]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0005355 glucose transmembrane transporter activity [PMID:20854260|PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:1904659 glucose transmembrane transport [PMID:20854260]
note: Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication
codon start: 1
product: hexose transporter HXT5
translation: MSELENAHQGPLEGSATVSTNSNSYNEKSGNSTAPGTAGYNDNLAQAKPVSSYISHEGPPKDELEELQKEVDKQLEKKSKSDLLFVSVCCLMVAFGGFVFGWDTGTISGFVRQTDFIRRFGSTRANGTTYLSDVRTGLMVSIFNIGCAIGGIVLSKLGDMYGRKIGLMTVVVIYSIGIIIQIASIDKWYQYFIGRIISGLGVGGITVLAPMLISEVSPKQLRGTLVSCYQLMITFGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWSIFMIVGMTFVPESPRYLVEVGKIEEAKRSLARANKTTEDSPLVTLEMENYQSSIEAERLAGSASWGELVTGKPQMFRRTLMGMMIQSLQQLTGDNYFFYYGTTIFQAVGLEDSFETAIVLGVVNFVSTFFSLYTVDRFGRRNCLLWGCVGMICCYVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPVAYVLISESYPLRVRGKAMSIASACNWIWGFLISFFTPFITSAINFYYGYVFMGCMVFAYFYVFFFVPETKGLTLEEVNEMYEENVLPWKSTKWIPPSRRTTDYDLDATRNDPRPFYKRMFTKEK
SIO_010081: YHR096C
subclass of: SO_0000673
so part of: YHR096C
location: complement(294669..296447)
location: region:294669-296447:-1
so has part: feature:294669-296447:-1:exon

NP_011964.1
type: Protein
SIO_000068: ncbiprotein

S000001138
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:294669-296447:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS815; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 297060..297179
location: region:297060-297179:1
so has part: feature:297060-297179:1:region

S000130150
type: SGD
SIO_000068: sgd

position:297060:1
position: 297060
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:297179:1
position: 297179
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297060-297179:1:region

YHR097C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCD1
gene: PAL2
locus tag: YHR097C
gene synonym: SCD1
so part of: sequence
location: complement(<297385..>298609)
location: region:297385-298609:-1
so has part: feature:297385-298609:-1:exon
subclass of: SO_0000010

856497
type: Gene
SIO_000068: ncbigene

position:297385:-1
position: 297385
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:298609:-1
position: 298609
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:297385-298609:-1:exon

YHR097C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCD1
gene: PAL2
locus tag: YHR097C
gene synonym: SCD1
product: Pal2p
transcript id: NM_001179227.1
SIO_010081: YHR097C
subclass of: SO_0000673
so part of: YHR097C
location: complement(join(<297385..298360,298485..>298609))
location: region:297385-298609:-1
so has part: feature:298485-298609:-1:exon
so has part: feature:297385-298360:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298485-298609:-1:exon

position:298485:-1
position: 298485
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:297385-298360:-1:exon

position:298360:-1
position: 298360
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR097C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCD1
gene: PAL2
locus tag: YHR097C
gene synonym: SCD1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:30679249]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
note: Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication
codon start: 1
product: Pal2p
translation: MNQTGRTIGGPQNGVNTVINPFRVSPSEDRVSSRDETPRNYNNPFLNEDDTRRAHNSSVSNSRQERLPSYEEAAGTPKQQAPYPKEKKRSSGSNSHQHNHHHHRRTSHGHRDKDKQKSKSRTKVKPPKNVDTIDKMDVTGLFGGSFHHDGPFDACTPQRNKNNKVAPVLAFPADGPNNTVGGRTSKKSTLDEVFGRETVDDDSETLNQLQDRAYLFNKANSSTTTLDAIKPNSKNITQFDSKMKTELVHGPITMGLGSTTFLDGAPASSAAIEQDVINHAQESRRKNSIARKKSLPSRRHLQVNNNNLKLVKTHSGHLEQKDVDDNRTSVPVTATQGSGHEDVVKKENTGNKLLRRVKSLKTSKKH
SIO_010081: YHR097C
subclass of: SO_0000673
so part of: YHR097C
location: complement(join(297385..298360,298485..298609))
location: region:297385-298609:-1
so has part: feature:298485-298609:-1:exon
so has part: feature:297385-298360:-1:exon

NP_011965.1
type: Protein
SIO_000068: ncbiprotein

S000001139
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298485-298609:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:297385-298360:-1:exon

YHR098C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LST1
gene: SFB3
locus tag: YHR098C
gene synonym: LST1
so part of: sequence
location: complement(<299145..>301934)
location: region:299145-301934:-1
so has part: feature:299145-301934:-1:exon
subclass of: SO_0000010

856498
type: Gene
SIO_000068: ncbigene

position:299145:-1
position: 299145
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301934:-1
position: 301934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:299145-301934:-1:exon

YHR098C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LST1
gene: SFB3
locus tag: YHR098C
gene synonym: LST1
product: Sfb3p
transcript id: NM_001179228.1
SIO_010081: YHR098C
subclass of: SO_0000673
so part of: YHR098C
location: complement(<299145..>301934)
location: region:299145-301934:-1
so has part: feature:299145-301934:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:299145-301934:-1:exon

YHR098C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LST1
gene: SFB3
locus tag: YHR098C
gene synonym: LST1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:11086000|PMID:12426382]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:12426382|PMID:12941277]
experiment: EXISTENCE:mutant phenotype:GO:0090110 COPII-coated vesicle cargo loading [PMID:12941277]
note: Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p
codon start: 1
product: Sfb3p
translation: MSQQNILAASVSALSLDESTVHTGGASSKKSRRPHRAYHNFSSGTVPTLGNSPYTTPQLNQQDGFQQPQAFTPKQFGGFNNGSGSVMSTPVMVSQERFGASEASSPYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDSVPPLPTTQFYCVDQGSCDPHLMSLSMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDGTPLRCRRCRAYANPKFQFTYDSSVICNICRVKMQVPGEHFAPMGPNGQRSDLNEKSELLHGTVDFLVPSIYNAIQEKELLPLHYVFLIDVSLLANENGSSLAMVEGVRSCIEYISDFQPNCEVAIIVYDNKLRFFNLRPDLDNAQEYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDKYSHVPQVCYGSALQAAKLALDTVTGGQGGKIICSLNSLPTIGNGNLSLKRDNAHIAHVKCDNGFYKKLASDFLKSYISLDLYVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVNDMVTNVSNIVGYQALLKVRCSTGLSVEQYYCDSSDNTDHDPIIPVLTRDTTLDVLLKYDSKIKTGTDVHFQTALLYTDIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIKDVIKTLGDCDFVKIRRLIDDKMVEILTQYRGLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNERIYDLLKYDSLNSAQLCYKLYPQIVPFHVLLEETDLTFYDANDKLLQINSSSINNLSVRASHSNFINGGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISLFSGTLPETGTSINQKASNVIKNWQQVVNKSSLPLVLLRPNVDQYYSNVMSQLLCEDKTVNRIESYDNYLVIMHKKIQEKLQKDDFIKVSTAATHENIHQKFVQF
SIO_010081: YHR098C
subclass of: SO_0000673
so part of: YHR098C
location: complement(299145..301934)
location: region:299145-301934:-1
so has part: feature:299145-301934:-1:exon

NP_011966.1
type: Protein
SIO_000068: ncbiprotein

S000001140
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:299145-301934:-1:exon

YHR099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRA1
locus tag: YHR099W
so part of: sequence
location: <302761..>313995
location: region:302761-313995:1
so has part: feature:302761-313995:1:exon
subclass of: SO_0000010

856499
type: Gene
SIO_000068: ncbigene

position:302761:1
position: 302761
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:313995:1
position: 313995
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302761-313995:1:exon

YHR099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRA1
locus tag: YHR099W
product: histone acetyltransferase TRA1
transcript id: NM_001179229.1
SIO_010081: YHR099W
subclass of: SO_0000673
so part of: YHR099W
location: <302761..>313995
location: region:302761-313995:1
so has part: feature:302761-313995:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:302761-313995:1:exon

YHR099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRA1
locus tag: YHR099W
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9885573]
experiment: EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10911987]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18616809]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:10911987]
experiment: EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]
experiment: EXISTENCE:direct assay:GO:0070209 ASTRA complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20635087]
note: Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
codon start: 1
product: histone acetyltransferase TRA1
translation: MSLTEQIEQFASRFRDDDATLQSRYSTLSELYDIMELLNSPEDYHFFLQAVIPLLLNQLKEVPISYDAHSPEQKLRNSMLDIFNRCLMNQTFQPYAMEVLEFLLSVLPKENEENGILCMKVLTTLFKSFKSILQDKLDSFIRIIIQIYKNTPNLINQTFYEAGKAEQGDLDSPKEPQADELLDEFSKNDEEKDFPSKQSSTEPRFENSTSSNGLRSSMFSFKILSECPITMVTLYSSYKQLTSTSLPEFTPLIMNLLNIQIKQQQEAREQAESRGEHFTSISTEIINRPAYCDFILAQIKATSFLAYVFIRGYAPEFLQDYVNFVPDLIIRLLQDCPSELSSARKELLHATRHILSTNYKKLFLPKLDYLFDERILIGNGFTMHETLRPLAYSTVADFIHNIRSELQLSEIEKTIKIYTGYLLDESLALTVQIMSAKLLLNLVERILKLGKENPQEAPRAKKLLMIIIDSYMNRFKTLNRQYDTIMKYYGRYETHKKEKAEKLKNSIQDNDKESEEFMRKVLEPSDDDHLMPQPKKEDINDSPDVEMTESDKVVKNDVEMFDIKNYAPILLLPTPTNDPIKDAFYLYRTLMSFLKTIIHDLKVFNPPPNEYTVANPKLWASVSRVFSYEEVIVFKDLFHECIIGLKFFKDHNEKLSPETTKKHFDISMPSLPVSATKDARELMDYLAFMFMQMDNATFNEIIEQELPFVYERMLEDSGLLHVAQSFLTSEITSPNFAGILLRFLKGKLKDLGNVDFNTSNVLIRLFKLSFMSVNLFPNINEVVLLPHLNDLILNSLKYSTTAEEPLVYFYLIRTLFRSIGGGRFENLYRSIKPILQVLLQSLNQMILTARLPHERELYVELCITVPVRLSVLAPYLPFLMKPLVFALQQYPDLVSQGLRTLELCIDNLTAEYFDPIIEPVIDDVSKALFNLLQPQPFNHAISHNVVRILGKLGGRNRQFLKPPTDLTEKTELDIDAIADFKINGMPEDVPLSVTPGIQSALNILQSYKSDIHYRKSAYKYLTCVLLLMTKSSAEFPTNYTELLKTAVNSIKLERIGIEKNFDLEPTVNKRDYSNQENLFLRLLESVFYATSIKELKDDAMDLLNNLLDHFCLLQVNTTLLNKRNYNGTFNIDLKNPNFMLDSSLILDAIPFALSYYIPEVREVGVLAYKRIYEKSCLIYGEELALSHSFIPELAKQFIHLCYDETYYNKRGGVLGIKVLIDNVKSSSVFLKKYQYNLANGLLFVLKDTQSEAPSAITDSAEKLLIDLLSITFADVKEEDLGNKVLENTLTDIVCELSNANPKVRNACQKSLHTISNLTGIPIVKLMDHSKQFLLSPIFAKPLRALPFTMQIGNVDAITFCLSLPNTFLTFNEELFRLLQESIVLADAEDESLSTNIQKTTEYSTSEQLVQLRIACIKLLAIALKNEEFATAQQGNIRIRILAVFFKTMLKTSPEIINTTYEALKGSLAENSKLPKELLQNGLKPLLMNLSDHQKLTVPGLDALSKLLELLIAYFKVEIGRKLLDHLTAWCRVEVLDTLFGQDLAEQMPTKIIVSIINIFHLLPPQADMFLNDLLLKVMLLERKLRLQLDSPFRTPLARYLNRFHNPVTEYFKKNMTLRQLVLFMCNIVQRPEAKELAEDFEKELDNFYDFYISNIPKNQVRVVSFFTNMVDLFNTMVITNGDEWLKKKGNMILKLKDMLNLTLKTIKENSFYIDHLQLNQSIAKFQALYLRFTELSERDQNPLLLDFIDFSFSNGIKASYSLKKFIFHNIIASSNKEKQNNFINDATLFVLSDKCLDARIFVLKNVINSTLIYEVATSGSLKSYLVEDKKPKWLELLHNKIWKNSNAILAYDVLDHHDLFRFELLQLSAIFIKADPEIIAEIKKDIIKFCWNFIKLEDTLIKQSAYLVTSYFISKFDFPIKVVTQVFVALLRSSHVEARYLVKQSLDVLTPVLHERMNAAGTPDTWINWVKRVMVENSSSQNNILYQFLISHPDLFFNSR…
SIO_010081: YHR099W
subclass of: SO_0000673
so part of: YHR099W
location: 302761..313995
location: region:302761-313995:1
so has part: feature:302761-313995:1:exon

NP_011967.1
type: Protein
SIO_000068: ncbiprotein

S000001141
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302761-313995:1:exon

YHR100C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GEP4
locus tag: YHR100C
so part of: sequence
location: complement(<314116..>314673)
location: region:314116-314673:-1
so has part: feature:314116-314673:-1:exon
subclass of: SO_0000010

856500
type: Gene
SIO_000068: ncbigene

position:314116:-1
position: 314116
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:314673:-1
position: 314673
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314116-314673:-1:exon

YHR100C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GEP4
locus tag: YHR100C
product: phosphatidylglycerophosphatase
transcript id: NM_001179230.1
SIO_010081: YHR100C
subclass of: SO_0000673
so part of: YHR100C
location: complement(<314116..>314673)
location: region:314116-314673:-1
so has part: feature:314116-314673:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:314116-314673:-1:exon

YHR100C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GEP4
locus tag: YHR100C
EC number: 3.1.3.27
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:20485265]
experiment: EXISTENCE:direct assay:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]
experiment: EXISTENCE:genetic interaction:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]
experiment: EXISTENCE:mutant phenotype:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]
experiment: EXISTENCE:mutant phenotype:GO:0032049 cardiolipin biosynthetic process [PMID:20485265]
note: Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT
codon start: 1
product: phosphatidylglycerophosphatase
translation: MNISGTLNTLRLLYNPSLCKPSLVVPTFNDLPIPIHDSIKAVVLDKDNCIAFPHDDKIWPDYLQHWETLRSKYSNKALLIVSNTAGSNSDKDYSQAKLLEDKTGIPVLRHSTKKPGCHNEILDYFYRNKTITNPKEVAVVGDRLFTDILMANLMGSYGVWIRDGVKVSANPLSKFEKKLYNFLGF
SIO_010081: YHR100C
subclass of: SO_0000673
so part of: YHR100C
location: complement(314116..314673)
location: region:314116-314673:-1
so has part: feature:314116-314673:-1:exon

NP_011968.1
type: Protein
SIO_000068: ncbiprotein

S000001142
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:314116-314673:-1:exon

YHR101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BIG1
locus tag: YHR101C
so part of: sequence
location: complement(<314874..>315968)
location: region:314874-315968:-1
so has part: feature:314874-315968:-1:exon
subclass of: SO_0000010

856501
type: Gene
SIO_000068: ncbigene

position:314874:-1
position: 314874
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:315968:-1
position: 315968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314874-315968:-1:exon

YHR101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BIG1
locus tag: YHR101C
product: Big1p
transcript id: NM_001179231.1
SIO_010081: YHR101C
subclass of: SO_0000673
so part of: YHR101C
location: complement(join(<314874..315771,315859..>315968))
location: region:314874-315968:-1
so has part: feature:315859-315968:-1:exon
so has part: feature:314874-315771:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:315859-315968:-1:exon

position:315859:-1
position: 315859
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:314874-315771:-1:exon

position:315771:-1
position: 315771
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BIG1
locus tag: YHR101C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12112232]
experiment: EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:12112232]
note: Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan
codon start: 1
product: Big1p
translation: MQTVLKYLLLIMCGSFCASEELQNQTNVPAIFFSYKLTPGILKYQEDYDRAVTLPRDTFIEAAEKFLGVCNADTYVFINQPGLRKLDFLEFETEFVSLQRYIRRSSTAIKFEKVDLLPQDLYYDLAEFVKEYCNVDQVLNLRGNNTEDFQPFIDSEKRVIIIEYPKLPEDTNERKEAFRHYDKYLRTILAQIPSPEQNVIYTSLNPGTTLAHESIIPIQIFPDIFDIKSRVGEVEQNNRVLDVPRLSFNDYTPRFSEPPSEYVSIFDSQLIENNRGLLQLIFTILVGYILIQFFFTKKTIVDEKITNKKDNVKQTSPQLLKKVQEIQKKPSQQVS
SIO_010081: YHR101C
subclass of: SO_0000673
so part of: YHR101C
location: complement(join(314874..315771,315859..315968))
location: region:314874-315968:-1
so has part: feature:315859-315968:-1:exon
so has part: feature:314874-315771:-1:exon

NP_011969.1
type: Protein
SIO_000068: ncbiprotein

S000001143
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:315859-315968:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:314874-315771:-1:exon

YHR102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NRK1
gene: KIC1
locus tag: YHR102W
gene synonym: NRK1
so part of: sequence
location: <316572..>319814
location: region:316572-319814:1
so has part: feature:316572-319814:1:exon
subclass of: SO_0000010

856502
type: Gene
SIO_000068: ncbigene

position:316572:1
position: 316572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:319814:1
position: 319814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316572-319814:1:exon

YHR102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NRK1
gene: KIC1
locus tag: YHR102W
gene synonym: NRK1
product: putative serine/threonine protein kinase KIC1
transcript id: NM_001179232.1
SIO_010081: YHR102W
subclass of: SO_0000673
so part of: YHR102W
location: <316572..>319814
location: region:316572-319814:1
so has part: feature:316572-319814:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316572-319814:1:exon

YHR102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NRK1
gene: KIC1
locus tag: YHR102W
gene synonym: NRK1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12972564]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:9813095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12480907]
note: Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis
codon start: 1
product: putative serine/threonine protein kinase KIC1
translation: MTTKPQNSKQGLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGDEAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEWATAQHDLFNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTNSKYPSKMVAGTTNTSGTHTAGPMTSSKRLESKAPKQLLELFEDNEIITAENDVNTEAPKISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALPLLQTKFNKTSKGPPTSGLTTAPTSIEIEIPEELPNSALPTPASADPVLIPSTKARSSTVTAGTPSSSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQKLGSAVASNSGISSTPNNSNNYNNNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPNRKPAGSPTQNIGHNSTHTNLAPPPTMKPMANSKDNKDILLQPLNSIPSSSTLNTISGNSSNNLTSSNYFSNEKEGSRVNGDFKRNNPNLKLQMPLPTPVVRNKLLDPNTATSQNNNGMPGSAGISTNENINQFGFNTSSASNIPVSMTPISEKHIDFGGKIKRSQSISNRKNSSASEHPLNILGSSVSGNVSGIGNNNVGSNNNSGPNNSVPLSANTGNTTIKANSTTIATSSSAAASTTAPISQQTIPSGTQFNHILSSAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQVLKELENLLQMFEEGLPCIEHALKEQLISTPIKDNEH
SIO_010081: YHR102W
subclass of: SO_0000673
so part of: YHR102W
location: 316572..319814
location: region:316572-319814:1
so has part: feature:316572-319814:1:exon

NP_011970.1
type: Protein
SIO_000068: ncbiprotein

S000001144
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316572-319814:1:exon

YHR103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SBE22
locus tag: YHR103W
so part of: sequence
location: <320414..>322972
location: region:320414-322972:1
so has part: feature:320414-322972:1:exon
subclass of: SO_0000010

856503
type: Gene
SIO_000068: ncbigene

position:320414:1
position: 320414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:322972:1
position: 322972
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:320414-322972:1:exon

YHR103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SBE22
locus tag: YHR103W
product: Sbe22p
transcript id: NM_001179233.1
SIO_010081: YHR103W
subclass of: SO_0000673
so part of: YHR103W
location: <320414..>322972
location: region:320414-322972:1
so has part: feature:320414-322972:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:320414-322972:1:exon

YHR103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SBE22
locus tag: YHR103W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10679005]
note: Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication
codon start: 1
product: Sbe22p
translation: MTSIQERGTSAHLHSLKEGEASDRSSEMLPKQRSIIGSHVQRPPSQTTLGRSRAGSNTMNKVSGLDIARRPSENLLSNMNCSDNGNGGNMLNSFVNSALPPPKVNPAQTRRERPASNSSIGTKTTEVFSSTSASSSLGDTSDEGEGSDADKSKINTFPSILMEKATQGRGADGNGMRSASNNTIVEATTDGSKMALQKSMSFDDTAAEKTMNKSRHSYQEQFSSKKSQSSLLNSKQRSRAKSQTCSSTGYNNSSILKTFGISSKISNSSDRIEASSLEFNVPSQKPLNCKPLTPSQKYRLRKEQSEMNLRNTIKRKEKFYDSQEQILELQEGDVDDSLIWNVPMASLSTNSFLASAKPDDMNNLAGKNDLSEYTGGLVNDNSEISYTKQNHRYSNISFASTTSNASLLDFNEMPTSPIPGLNKVTDFQFIQDTTKSLASVYLHSSNRLSRSKLSERTKSSDFLPIELKEAQNQGMEDLILVSENKLDVVSHSRPSWLPPKDRQEKKLHERQINKSMSVASLDQLGKNKDREEKLIRDETNRQKYVLLLDRDITRNSSLQSLSKMVWDTPFSDETRSTIYSEILQSKTRFITKNYIQPFHELQELLTKMGDFPKNKEIEISQLIETSLRRKVSGLHDICPDLMLLLKIKSISSQGIVTGDELLFHHFLVSESFQNLGLNEIWNIVNLVQMTCFNDLCKEKFDAKVLERKGVVAGYLSQNEEFKDEFNTECINSTTWWNILERIDHKLFMWIMDIIVVNNSQSYKNSPINEDEFVNKDWEYYRSKKVVINYKILISFALNVLLNYHFGFTDLRSLCNVNDQRFCIPVFINDEFVDADTVNAVFIKKWAHYYKKF
SIO_010081: YHR103W
subclass of: SO_0000673
so part of: YHR103W
location: 320414..322972
location: region:320414-322972:1
so has part: feature:320414-322972:1:exon

NP_011971.1
type: Protein
SIO_000068: ncbiprotein

S000001145
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:320414-322972:1:exon

YHR104W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRE3
locus tag: YHR104W
so part of: sequence
location: <323409..>324392
location: region:323409-324392:1
so has part: feature:323409-324392:1:exon
subclass of: SO_0000010

856504
type: Gene
SIO_000068: ncbigene

position:323409:1
position: 323409
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:324392:1
position: 324392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:323409-324392:1:exon

YHR104W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRE3
locus tag: YHR104W
product: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
transcript id: NM_001179234.1
SIO_010081: YHR104W
subclass of: SO_0000673
so part of: YHR104W
location: <323409..>324392
location: region:323409-324392:1
so has part: feature:323409-324392:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:323409-324392:1:exon

YHR104W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRE3
locus tag: YHR104W
EC number: 1.1.1.21
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]
experiment: EXISTENCE:direct assay:GO:0004032 alditol:NADP+ 1-oxidoreductase activity [PMID:11306085|PMID:11525399]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]
experiment: EXISTENCE:direct assay:GO:0032866 D-xylose:NADP reductase activity [PMID:11481678]
experiment: EXISTENCE:direct assay:GO:0042843 D-xylose catabolic process [PMID:12271459]
experiment: EXISTENCE:direct assay:GO:0071470 cellular response to osmotic stress [PMID:11525399]
experiment: EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:18811659]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]
experiment: EXISTENCE:mutant phenotype:GO:0019568 arabinose catabolic process [PMID:12271459]
experiment: EXISTENCE:mutant phenotype:GO:0032866 D-xylose:NADP reductase activity [PMID:11481678]
experiment: EXISTENCE:mutant phenotype:GO:0042843 D-xylose catabolic process [PMID:12271459]
note: Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress
codon start: 1
product: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
translation: MSSLVTLNNGLKMPLVGLGCWKIDKKVCANQIYEAIKLGYRLFDGACDYGNEKEVGEGIRKAISEGLVSRKDIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGADDEKKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHHPYLTQEHLVEFCKLHDIQVVAYSSFGPQSFIEMDLQLAKTTPTLFENDVIKKVSQNHPGSTTSQVLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIRFNDPWTWLDGKFPTFA
SIO_010081: YHR104W
subclass of: SO_0000673
so part of: YHR104W
location: 323409..324392
location: region:323409-324392:1
so has part: feature:323409-324392:1:exon

NP_011972.1
type: Protein
SIO_000068: ncbiprotein

S000001146
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:323409-324392:1:exon

YHR105W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPT35
locus tag: YHR105W
so part of: sequence
location: <324766..>325410
location: region:324766-325410:1
so has part: feature:324766-325410:1:exon
subclass of: SO_0000010

856505
type: Gene
SIO_000068: ncbigene

position:324766:1
position: 324766
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:325410:1
position: 325410
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:324766-325410:1:exon

YHR105W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPT35
locus tag: YHR105W
product: Ypt35p
transcript id: NM_001179235.1
SIO_010081: YHR105W
subclass of: SO_0000673
so part of: YHR105W
location: <324766..>325410
location: region:324766-325410:1
so has part: feature:324766-325410:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:324766-325410:1:exon

YHR105W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPT35
locus tag: YHR105W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
note: Endosomal hypothetical protein; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
codon start: 1
product: Ypt35p
translation: MSDKISFLPPEPIQLLDEDSTEPELDIDSQQENEGPISASNSNDSTSHSNDCGATITRTRPRRSSSINANFSFQKAHVSDCTIVNGDHGTKFAVWRITVFLEPNLKAFAAKRESYKIQTYKRYSDFVRLRENLLTRIKTAKPEKLNCLQIPHLPPSVQWYSSWKYQEVNLNKDWLAKRQRGLEYFLNHIILNSSLVEMTKDILIQFLEPSKRVA
SIO_010081: YHR105W
subclass of: SO_0000673
so part of: YHR105W
location: 324766..325410
location: region:324766-325410:1
so has part: feature:324766-325410:1:exon

NP_011973.1
type: Protein
SIO_000068: ncbiprotein

S000001147
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:324766-325410:1:exon

YHR106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRR2
locus tag: YHR106W
so part of: sequence
location: <325598..>326626
location: region:325598-326626:1
so has part: feature:325598-326626:1:exon
subclass of: SO_0000010

856506
type: Gene
SIO_000068: ncbigene

position:325598:1
position: 325598
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326626:1
position: 326626
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325598-326626:1:exon

YHR106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRR2
locus tag: YHR106W
product: thioredoxin-disulfide reductase TRR2
transcript id: NM_001179236.1
SIO_010081: YHR106W
subclass of: SO_0000673
so part of: YHR106W
location: <325598..>326626
location: region:325598-326626:1
so has part: feature:325598-326626:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325598-326626:1:exon

YHR106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRR2
locus tag: YHR106W
EC number: 1.8.1.9
experiment: EXISTENCE:curator inference:GO:0045454 cell redox homeostasis [PMID:10037727]
experiment: EXISTENCE:direct assay:GO:0004791 thioredoxin-disulfide reductase activity [PMID:10037727]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10037727|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10037727]
note: Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
codon start: 1
product: thioredoxin-disulfide reductase TRR2
translation: MIKHIVSPFRTNFVGISKSVLSRMIHHKVTIIGSGPAAHTAAIYLARAEMKPTLYEGMMANGIAAGGQLTTTTDIENFPGFPESLSGSELMERMRKQSAKFGTNIITETVSKVDLSSKPFRLWTEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQQGISACAVCDGAVPIFRNKPLAVIGGGDSACEEAEFLTKYASKVYILVRKDHFRASVIMQRRIEKNPNIIVLFNTVALEAKGDGKLLNMLRIKNTKSNVENDLEVNGLFYAIGHSPATDIVKGQVDEEETGYIKTVPGSSLTSVPGFFAAGDVQDSRYRQAVTSAGSGCIAALDAERYLSAQE
SIO_010081: YHR106W
subclass of: SO_0000673
so part of: YHR106W
location: 325598..326626
location: region:325598-326626:1
so has part: feature:325598-326626:1:exon

NP_011974.1
type: Protein
SIO_000068: ncbiprotein

S000001148
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325598-326626:1:exon

YHR107C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLA10
alternative label: PSL7
gene: CDC12
locus tag: YHR107C
gene synonym: CLA10; PSL7
so part of: sequence
location: complement(<326813..>328036)
location: region:326813-328036:-1
so has part: feature:326813-328036:-1:exon
subclass of: SO_0000010

856507
type: Gene
SIO_000068: ncbigene

position:326813:-1
position: 326813
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:328036:-1
position: 328036
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326813-328036:-1:exon

YHR107C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLA10
alternative label: PSL7
gene: CDC12
locus tag: YHR107C
gene synonym: CLA10; PSL7
product: septin CDC12
transcript id: NM_001179237.1
SIO_010081: YHR107C
subclass of: SO_0000673
so part of: YHR107C
location: complement(<326813..>328036)
location: region:326813-328036:-1
so has part: feature:326813-328036:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326813-328036:-1:exon

YHR107C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLA10
alternative label: PSL7
gene: CDC12
locus tag: YHR107C
gene synonym: CLA10; PSL7
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:3316985]
experiment: EXISTENCE:direct assay:GO:0000921 septin ring assembly [PMID:12636916]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:14993234]
experiment: EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:18550837|PMID:22144691|PMID:29321251]
experiment: EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14597621]
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:23345395]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005937 mating projection [PMID:18552279]
experiment: EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]
experiment: EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]
experiment: EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]
experiment: EXISTENCE:direct assay:GO:0045860 positive regulation of protein kinase activity [PMID:14527412]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]
experiment: EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]
experiment: EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:14993234]
experiment: EXISTENCE:mutant phenotype:GO:0030011 maintenance of cell polarity [PMID:10882120]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9442111]
experiment: EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:9864366]
experiment: EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]
note: Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
codon start: 1
product: septin CDC12
translation: MSAATATAAPVPPPVGISNLPNQRYKIVNEEGGTFTVMLCGESGLGKTTFINTLFQTVLKRADGQQHRQEPIRKTVEIDITRALLEEKHFELRVNVIDTPGFGDNVNNNKAWQPLVDFIDDQHDSYMRQEQQPYRTKKFDLRVHAVLYFIRPTGHGLKPIDIETMKRLSTRANLIPVIAKADTLTAQELQQFKSRIRQVIEAQEIRIFTPPLDADSKEDAKSGSNPDSAAVEHARQLIEAMPFAIVGSEKKFDNGQGTQVVARKYPWGLVEIENDSHCDFRKLRALLLRTYLLDLISTTQEMHYETYRRLRLEGHENTGEGNEDFTLPAIAPARKLSHNPRYKEEENALKKYFTDQVKAEEQRFRQWEQNIVNERIRLNGDLEEIQGKVKKLEEQVKSLQVKKSHLK
SIO_010081: YHR107C
subclass of: SO_0000673
so part of: YHR107C
location: complement(326813..328036)
location: region:326813-328036:-1
so has part: feature:326813-328036:-1:exon

NP_011975.1
type: Protein
SIO_000068: ncbiprotein

S000001149
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326813-328036:-1:exon

YHR108W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GGA2
locus tag: YHR108W
so part of: sequence
location: <328303..>330060
location: region:328303-330060:1
so has part: feature:328303-330060:1:exon
subclass of: SO_0000010

856508
type: Gene
SIO_000068: ncbigene

position:328303:1
position: 328303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330060:1
position: 330060
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328303-330060:1:exon

YHR108W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GGA2
locus tag: YHR108W
product: phosphatidylinositol 4-phosphate-binding protein
transcript id: NM_001179238.1
SIO_010081: YHR108W
subclass of: SO_0000673
so part of: YHR108W
location: <328303..>330060
location: region:328303-330060:1
so has part: feature:328303-330060:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:328303-330060:1:exon

YHR108W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GGA2
locus tag: YHR108W
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:10747088]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:15039776]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18287542]
experiment: EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:10747088]
experiment: EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:15039776]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10747088]
experiment: EXISTENCE:mutant phenotype:GO:0043130 ubiquitin binding [PMID:19574226]
experiment: EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15039776]
experiment: EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18287542]
note: Protein that regulates Arf1p and Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; K63-specific Ub chain binding receptor with moderate selectivity; homologous to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol 4-phosphate-binding protein
translation: MSHPHSHSIYLSELPVRKPQALGNPLLRKIQRACRMSLAEPDLALNLDIADYINEKQGAAPRDAAIALAKLINNRESHVAIFALSLLDVLVKNCGYPFHLQISRKEFLNELVKRFPGHPPLRYSKIQRLILTAIEEWYQTICKHSSYKNDMGYIRDMHRLLKYKGYAFPKISESDLAVLKPSNQLKTASEIQKEQEIAQAAKLEELIRRGKPEDLREANKLMKIMAGFKEDNAVQAKQAISSELNKLKRKADLLNEMLESPDSQNWDNETTQELHSALKVAQPKFQKIIEEEQEDDALVQDLLKFNDTVNQLLEKFNLLKNGDSNAASQIHPSHVSAPLQQSSGALTNEINLIDFNDLDEAPSQGNNNTNGTGTPAAAETSVNDLLGDLTDLSISNPSTANQASFGLGGDIVLGSSQPAPPVTTTNNSNNTLDLLGLSTPQSPTNSQAVNSSGFDLLMGFNPTTGTTTAPARTLVNQSPNLKIEFEISRESNSVIRIKSFFTNLSSSPISNLVFLLAVPKSMSLKLQPQSSNFMIGNAKDGISQEGTIENAPANPSKALKVKWKVNYSVNSTQAEETAVFTLPNV
SIO_010081: YHR108W
subclass of: SO_0000673
so part of: YHR108W
location: 328303..330060
location: region:328303-330060:1
so has part: feature:328303-330060:1:exon

NP_011976.1
type: Protein
SIO_000068: ncbiprotein

S000001150
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328303-330060:1:exon

YHR109W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTM1
locus tag: YHR109W
so part of: sequence
location: <330310..>332067
location: region:330310-332067:1
so has part: feature:330310-332067:1:exon
subclass of: SO_0000010

856509
type: Gene
SIO_000068: ncbigene

position:330310:1
position: 330310
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332067:1
position: 332067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330310-332067:1:exon

YHR109W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTM1
locus tag: YHR109W
product: cytochrome c lysine N-methyltransferase
transcript id: NM_001179239.1
SIO_010081: YHR109W
subclass of: SO_0000673
so part of: YHR109W
location: <330310..>332067
location: region:330310-332067:1
so has part: feature:330310-332067:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330310-332067:1:exon

YHR109W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTM1
locus tag: YHR109W
EC number: 2.1.1.59
experiment: EXISTENCE:direct assay:GO:0000277 [cytochrome c]-lysine N-methyltransferase activity [PMID:10791961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10791961]
experiment: EXISTENCE:direct assay:GO:0018022 peptidyl-lysine methylation [PMID:10791961]
experiment: EXISTENCE:mutant phenotype:GO:0000277 [cytochrome c]-lysine N-methyltransferase activity [PMID:10791961]
note: Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
codon start: 1
product: cytochrome c lysine N-methyltransferase
translation: MEEVFRFYSNSRNIFIHKSLSLKPSTIDDPKSGYGLFVEPSKFKNDELKSETIQLLRIPKRCTFNINTLLALLGDEDEFSSKEEFQRTNDKIKIALREIMAHPNFSVFLTETNLLIIYFMIFQTIRSRYEIPENIQYYLENVLMSIEVETAMDSIENLATDYGHYPQIFGLRETLNLFKELFHDVLNLSDIKHLYSAIISRCLEIPERADTKSEEFTVHSTLVPIVDFANHEGTQKNAYFDIDPSNNDVLLLLDTKAVQSELTKPIEVFISYSPTEDLFSMLVTYGFTPDFRGNSQFWTVSFDRCFLRNYDGPDKTTNLRLFYKWMHINPVVPLVKYEHNGKTRWFLNDTTPEFDMLLLPFIPSIDDGKIARWAYDSTCHLMFTKIHCLINPEANEHALMIAENYRSLIKEKESNGDDFINLPPLAWSLRYKDTENDCVRQRHICSEDAVAVLKQEEMQDSTKTKSQFTSFFRKFLEFRRSKIIRPTSDSKVASILYQQELEIIADLAKAIDSSSTIFFSDLNVTLDTEPERLPPLRFLDDYIEISADKQEPSPICEDLSYYTPSRFTDFFQEEVSQYAAFFQDD
SIO_010081: YHR109W
subclass of: SO_0000673
so part of: YHR109W
location: 330310..332067
location: region:330310-332067:1
so has part: feature:330310-332067:1:exon

NP_011977.1
type: Protein
SIO_000068: ncbiprotein

S000001151
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330310-332067:1:exon

YHR110W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERP5
locus tag: YHR110W
so part of: sequence
location: <332282..>332920
location: region:332282-332920:1
so has part: feature:332282-332920:1:exon
subclass of: SO_0000010

856510
type: Gene
SIO_000068: ncbigene

position:332282:1
position: 332282
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332920:1
position: 332920
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:332282-332920:1:exon

YHR110W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERP5
locus tag: YHR110W
product: Erp5p
transcript id: NM_001179240.1
SIO_010081: YHR110W
subclass of: SO_0000673
so part of: YHR110W
location: <332282..>332920
location: region:332282-332920:1
so has part: feature:332282-332920:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:332282-332920:1:exon

YHR110W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERP5
locus tag: YHR110W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport
codon start: 1
product: Erp5p
translation: MKYNIVHGICLLFAITQAVGAVHFYAKSGETKCFYEHLSRGNLLIGDLDLYVEKDGLFEEDPESSLTITVDETFDNDHRVLNQKNSHTGDVTFTALDTGEHRFCFTPFYSKKSATLRVFIELEIGNVEALDSKKKEDMNSLKGRVGQLTQRLSSIRKEQDAIREKEAEFRNQSESANSKIMTWSVFQLLILLGTCAFQLRYLKNFFVKQKVV
SIO_010081: YHR110W
subclass of: SO_0000673
so part of: YHR110W
location: 332282..332920
location: region:332282-332920:1
so has part: feature:332282-332920:1:exon

NP_011978.1
type: Protein
SIO_000068: ncbiprotein

S000001152
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:332282-332920:1:exon

YHR111W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YHR1
gene: UBA4
locus tag: YHR111W
gene synonym: YHR1
so part of: sequence
location: <333072..>334394
location: region:333072-334394:1
so has part: feature:333072-334394:1:exon
subclass of: SO_0000010

856511
type: Gene
SIO_000068: ncbigene

position:333072:1
position: 333072
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334394:1
position: 334394
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:333072-334394:1:exon

YHR111W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YHR1
gene: UBA4
locus tag: YHR111W
gene synonym: YHR1
product: Uba4p
transcript id: NM_001179241.1
SIO_010081: YHR111W
subclass of: SO_0000673
so part of: YHR111W
location: <333072..>334394
location: region:333072-334394:1
so has part: feature:333072-334394:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:333072-334394:1:exon

YHR111W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YHR1
gene: UBA4
locus tag: YHR111W
gene synonym: YHR1
experiment: EXISTENCE:direct assay:GO:0004792 thiosulfate sulfurtransferase activity [PMID:19864628]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0032447 protein urmylation [PMID:10713047]
experiment: EXISTENCE:direct assay:GO:0042292 URM1 activating enzyme activity [PMID:10713047]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]
experiment: EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:14551258]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]
experiment: EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:18664566|PMID:19145231|PMID:19151091]
experiment: EXISTENCE:mutant phenotype:GO:0016783 sulfurtransferase activity [PMID:19145231]
experiment: EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14555475]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14555475]
experiment: EXISTENCE:mutant phenotype:GO:0070733 protein adenylyltransferase activity [PMID:19145231]
experiment: EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]
note: E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
codon start: 1
product: Uba4p
translation: MNDYHLEDTTSELEALRLENAQLREQLAKREDSSRDYPLSLEEYQRYGRQMIVEETGGVAGQVKLKNTKVLVVGAGGLGCPALPYLAGAGVGQIGIVDNDVVETSNLHRQVLHDSSRVGMLKCESARQYITKLNPHINVVTYPVRLNSSNAFDIFKGYNYILDCTDSPLTRYLVSDVAVNLGITVVSASGLGTEGQLTILNFNNIGPCYRCFYPTPPPPNAVTSCQEGGVIGPCIGLVGTMMAVETLKLILGIYTNENFSPFLMLYSGFPQQSLRTFKMRGRQEKCLCCGKNRTITKEAIEKGEINYELFCGARNYNVCEPDERISVDAFQRIYKDDEFLAKHIFLDVRPSHHYEISHFPEAVNIPIKNLRDMNGDLKKLQEKLPSVEKDSNIVILCRYGNDSQLATRLLKDKFGFSNVRDVRGGYFKYIDDIDQTIPKY
SIO_010081: YHR111W
subclass of: SO_0000673
so part of: YHR111W
location: 333072..334394
location: region:333072-334394:1
so has part: feature:333072-334394:1:exon

NP_011979.1
type: Protein
SIO_000068: ncbiprotein

S000001153
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:333072-334394:1:exon

YHR112C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR112C
so part of: sequence
location: complement(<334527..>335663)
location: region:334527-335663:-1
so has part: feature:334527-335663:-1:exon
subclass of: SO_0000010

856512
type: Gene
SIO_000068: ncbigene

position:334527:-1
position: 334527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:335663:-1
position: 335663
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334527-335663:-1:exon

YHR112C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR112C
product: putative cystathionine beta-lyase
transcript id: NM_001179242.1
SIO_010081: YHR112C
subclass of: SO_0000673
so part of: YHR112C
location: complement(<334527..>335663)
location: region:334527-335663:-1
so has part: feature:334527-335663:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334527-335663:-1:exon

YHR112C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR112C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21777356|PMID:14562095]
note: hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway
codon start: 1
product: putative cystathionine beta-lyase
translation: MVDLSTALIHGDDKDNRVTDVAPPINVSTTFRYDDDDLIPWTERENLDFMEKKPVYSRLAHPNSTRLESIFSEILDGYAVIYSSGLAAFYAAMVHYNPKKIFIGQSYHGVRAIANILTRNYGIEQHPLEDIEKCASEGDIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSEFDKVLKTIYHSSLQTEEFVKKQLVGGYGPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMTDPYIDQTLIRVSVGCESANDLIKDLASALKELQDAA
SIO_010081: YHR112C
subclass of: SO_0000673
so part of: YHR112C
location: complement(334527..335663)
location: region:334527-335663:-1
so has part: feature:334527-335663:-1:exon

NP_011980.1
type: Protein
SIO_000068: ncbiprotein

S000001154
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334527-335663:-1:exon

YHR113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: APE4
locus tag: YHR113W
so part of: sequence
location: <336337..>337809
location: region:336337-337809:1
so has part: feature:336337-337809:1:exon
subclass of: SO_0000010

856513
type: Gene
SIO_000068: ncbigene

position:336337:1
position: 336337
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337809:1
position: 337809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:336337-337809:1:exon

YHR113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: APE4
locus tag: YHR113W
product: aspartyl aminopeptidase
transcript id: NM_001179243.1
SIO_010081: YHR113W
subclass of: SO_0000673
so part of: YHR113W
location: <336337..>337809
location: region:336337-337809:1
so has part: feature:336337-337809:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:336337-337809:1:exon

YHR113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: APE4
locus tag: YHR113W
EC number: 3.4.11.21
experiment: EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:21343297]
experiment: EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:16367759]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006508 proteolysis [PMID:15606766]
note: Cytoplasmic aspartyl aminopeptidase with possible vacuole function; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms 12-subunit homo-oligomer; M18 metalloprotease family
codon start: 1
product: aspartyl aminopeptidase
translation: MFRIQLRTMSSKTCKSDYPKEFVSFLNSSHSPYHTVHNIKKHLVSNGFKELSERDSWAGHVAQKGKYFVTRNGSSIIAFAVGGKWEPGNPIAITGAHTDSPALRIKPISKRVSEKYLQVGVETYGGAIWHSWFDKDLGVAGRVFVKDAKTGKSIARLVDLNRPLLKIPTLAIHLDRDVNQKFEFNRETQLLPIGGLQEDKTEAKTEKEINNGEFTSIKTIVQRHHAELLGLIAKELAIDTIEDIEDFELILYDHNASTLGGFNDEFVFSGRLDNLTSCFTSMHGLTLAADTEIDRESGIRLMACFDHEEIGSSSAQGADSNFLPNILERLSILKGDGSDQTKPLFHSAILETSAKSFFLSSDVAHAVHPNYANKYESQHKPLLGGGPVIKINANQRYMTNSPGLVLVKRLAEAAKVPLQLFVVANDSPCGSTIGPILASKTGIRTLDLGNPVLSMHSIRETGGSADLEFQIKLFKEFFERYTSIESEIVV
SIO_010081: YHR113W
subclass of: SO_0000673
so part of: YHR113W
location: 336337..337809
location: region:336337-337809:1
so has part: feature:336337-337809:1:exon

NP_011981.1
type: Protein
SIO_000068: ncbiprotein

S000001155
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:336337-337809:1:exon

YHR114W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LSB7
gene: BZZ1
locus tag: YHR114W
gene synonym: LSB7
so part of: sequence
location: <338083..>339984
location: region:338083-339984:1
so has part: feature:338083-339984:1:exon
subclass of: SO_0000010

856514
type: Gene
SIO_000068: ncbigene

position:338083:1
position: 338083
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339984:1
position: 339984
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:338083-339984:1:exon

YHR114W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LSB7
gene: BZZ1
locus tag: YHR114W
gene synonym: LSB7
product: Bzz1p
transcript id: NM_001179244.1
SIO_010081: YHR114W
subclass of: SO_0000673
so part of: YHR114W
location: <338083..>339984
location: region:338083-339984:1
so has part: feature:338083-339984:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:338083-339984:1:exon

YHR114W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LSB7
gene: BZZ1
locus tag: YHR114W
gene synonym: LSB7
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:25620000]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16824951]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12391157|PMID:16824951]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:16231105]
experiment: EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:12391157]
experiment: EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:16824951]
experiment: EXISTENCE:mutant phenotype:GO:0045010 actin nucleation [PMID:16824951]
experiment: EXISTENCE:physical interaction:GO:0007015 actin filament organization [PMID:12391157]
experiment: EXISTENCE:physical interaction:GO:0009651 response to salt stress [PMID:12391157]
note: SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins
codon start: 1
product: Bzz1p
translation: MSADLSIGNEIKDSFKETHKWVQNNLKWLKDIEQFYRERAKLEKDYSERLSRLSAEYFNKKSSTSVPISVGDTPTTTPGSIEAAGVVAWNEILSQTDMISKDHDQLSTDFENHVANQLSGLFTKLDMTLSKINGFNNDMVNKKDNIYHELEKAKKDYDEACSTMEMARNRYTKASNDRNKKKLDEKEMEMNKCKNEYLIKINQANRTKDKYYFQDVPEVLDLLQDVNEAKTLFLNDLWLKAASVENDLGANVSKRLQAANSVVKQNKPSLNTAIFIKHNLKNWKEPQDFVYKPSPVWHDDEKFAVPSSLEVEDLRIKLAKAENDYNSLQDKTQNELSKLSTLNKIKHEMKTNEDNINATKFYDTLKEYLNVVSPFTSHETLKLQAEVQIESIQNNVPEEYDLSTDNIDLSKTKKKSGIFSKFKHNILNVDSKPSSGGSTGNGNGGPLHITSLFNTSRRTRLGSAPNNAGEDSDNNSIRTTSTNNTKKTTQNSSDDGKNKVLYAYVQKDDDEITITPGDKISLVARDTGSGWTKINNDTTGETGLVPTTYIRISSAATVKANDRGPAPEVPPPRRSTLPVRTMEAIYAYEAQGDDEISIDPGDIITVIRGDDGSGWTYGECDGLKGLFPTSYCK
SIO_010081: YHR114W
subclass of: SO_0000673
so part of: YHR114W
location: 338083..339984
location: region:338083-339984:1
so has part: feature:338083-339984:1:exon

NP_011982.1
type: Protein
SIO_000068: ncbiprotein

S000001156
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:338083-339984:1:exon

YHR115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CHF1
gene: DMA1
locus tag: YHR115C
gene synonym: CHF1
so part of: sequence
location: complement(<340109..>341359)
location: region:340109-341359:-1
so has part: feature:340109-341359:-1:exon
subclass of: SO_0000010

856515
type: Gene
SIO_000068: ncbigene

position:340109:-1
position: 340109
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:341359:-1
position: 341359
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:340109-341359:-1:exon

YHR115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CHF1
gene: DMA1
locus tag: YHR115C
gene synonym: CHF1
product: ubiquitin-conjugating protein DMA1
transcript id: NM_001179245.1
SIO_010081: YHR115C
subclass of: SO_0000673
so part of: YHR115C
location: complement(<340109..>341359)
location: region:340109-341359:-1
so has part: feature:340109-341359:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:340109-341359:-1:exon

YHR115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CHF1
gene: DMA1
locus tag: YHR115C
gene synonym: CHF1
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:23264631]
experiment: EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:18202552]
experiment: EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21562220]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:15146058|PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:22570619]
experiment: EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:22570619]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]
experiment: EXISTENCE:mutant phenotype:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]
experiment: EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]
note: Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication
codon start: 1
product: ubiquitin-conjugating protein DMA1
translation: MSTNTVPSSPPNQTPPAASGIATSHDHTKFNNPIRLPISISLTINDTPNNNSNNNSVSNGLGILPSRTATSLVVANNGSANGNVGATAAAAATVETNTAPAVNTTKSIRHFIYPPNQVNQTEFSLDIHLPPNTSLPERIDQSTLKRRMDKHGLFSIRLTPFIDTSSTSVANQGLFFDPIIRTAGAGSQIIIGRYTERVREAISKIPDQYHPVVFKSKVISRTHGCFKVDDQGNWFLKDVKSSSGTFLNHQRLSSASTTSKDYLLHDGDIIQLGMDFRGGTEEIYRCVKMKIELNKSWKLKANAFNKEALSRIKNLQKLTTGLEQEDCSICLNKIKPCQAIFISPCAHSWHFHCVRRLVIMNYPQFMCPNCRTNCDLETTLESESESEFENEDEDEPDIEMDIDMEINNNLGVRLVD
SIO_010081: YHR115C
subclass of: SO_0000673
so part of: YHR115C
location: complement(340109..341359)
location: region:340109-341359:-1
so has part: feature:340109-341359:-1:exon

NP_011983.1
type: Protein
SIO_000068: ncbiprotein

S000001157
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:340109-341359:-1:exon

YHR116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX23
locus tag: YHR116W
so part of: sequence
location: <341665..>342120
location: region:341665-342120:1
so has part: feature:341665-342120:1:exon
subclass of: SO_0000010

856516
type: Gene
SIO_000068: ncbigene

position:341665:1
position: 341665
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:342120:1
position: 342120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:341665-342120:1:exon

YHR116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX23
locus tag: YHR116W
product: Cox23p
transcript id: NM_001179246.1
SIO_010081: YHR116W
subclass of: SO_0000673
so part of: YHR116W
location: <341665..>342120
location: region:341665-342120:1
so has part: feature:341665-342120:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:341665-342120:1:exon

YHR116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX23
locus tag: YHR116W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15145942|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15145942]
experiment: EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]
note: Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
codon start: 1
product: Cox23p
translation: MEKPSPTRRQTSSLSTISNGMTMTNDNRDTTNTNSGSTSSNNSQPSSSSTPPAASGPVTDRTKVNYVPKSDDPSSFQYYPDDPENPVNKYKFALKADSQYYDPCEESSKLSFQCLERNDYDRSKCQEYFDAYRECKKQWLTARRKNRQQWE
SIO_010081: YHR116W
subclass of: SO_0000673
so part of: YHR116W
location: 341665..342120
location: region:341665-342120:1
so has part: feature:341665-342120:1:exon

NP_011984.1
type: Protein
SIO_000068: ncbiprotein

S000001158
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:341665-342120:1:exon

YHR117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TOM72
gene: TOM71
locus tag: YHR117W
gene synonym: TOM72
so part of: sequence
location: <342349..>344268
location: region:342349-344268:1
so has part: feature:342349-344268:1:exon
subclass of: SO_0000010

856517
type: Gene
SIO_000068: ncbigene

position:342349:1
position: 342349
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:344268:1
position: 344268
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342349-344268:1:exon

YHR117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TOM72
gene: TOM71
locus tag: YHR117W
gene synonym: TOM72
product: protein channel TOM71
transcript id: NM_001179247.1
SIO_010081: YHR117W
subclass of: SO_0000673
so part of: YHR117W
location: <342349..>344268
location: region:342349-344268:1
so has part: feature:342349-344268:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342349-344268:1:exon

YHR117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TOM72
gene: TOM71
locus tag: YHR117W
gene synonym: TOM72
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:8663394|PMID:16407407]
experiment: EXISTENCE:genetic interaction:GO:0006626 protein targeting to mitochondrion [PMID:18007655]
experiment: EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:18007655]
note: Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
codon start: 1
product: protein channel TOM71
translation: MAENSLLRFITKNKVAILATVSAGTAAVGAYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLKDDGSVVSGSNKRKKKKNKRKRNNKAKSGEGFDYPSLPNGEPDIAQLKGLSPSQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKVLNENLSKDEGRGSQVLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSANTVDDPLRENAALALCYTGIFHFLKNNLLDAQVLLQESINLHPTPNSYIFLALTLADKENSQEFFKFFQKAVDLNPEYPPTYYHRGQMYFILQDYKNAKEDFQKAQSLNPENVYPYIQLACLLYKQGKFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGIGPLIGKATILARQSSQDPTQLDEEKFNAAIKLLTKACELDPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKRLRADPIISAKMELTLARYRAKGML
SIO_010081: YHR117W
subclass of: SO_0000673
so part of: YHR117W
location: 342349..344268
location: region:342349-344268:1
so has part: feature:342349-344268:1:exon

NP_011985.1
type: Protein
SIO_000068: ncbiprotein

S000001159
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342349-344268:1:exon

YHR118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ORC6
locus tag: YHR118C
so part of: sequence
location: complement(<344321..>345628)
location: region:344321-345628:-1
so has part: feature:344321-345628:-1:exon
subclass of: SO_0000010

856518
type: Gene
SIO_000068: ncbigene

position:344321:-1
position: 344321
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345628:-1
position: 345628
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:344321-345628:-1:exon

YHR118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ORC6
locus tag: YHR118C
product: origin recognition complex subunit 6
transcript id: NM_001179248.1
SIO_010081: YHR118C
subclass of: SO_0000673
so part of: YHR118C
location: complement(<344321..>345628)
location: region:344321-345628:-1
so has part: feature:344321-345628:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:344321-345628:-1:exon

YHR118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ORC6
locus tag: YHR118C
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
experiment: EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:17053779]
note: Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome
codon start: 1
product: origin recognition complex subunit 6
translation: MSMQQVQHCVAEVLRLDPQEKPDWSSGYLKKLTNATSILYNTSLNKVMLKQDEEVARCHICAYIASQKMNEKHMPDLCYYIDSIPLEPKKAKHLMNLFRQSLSNSSPMKQFAWTPSPKKNKRSPVKNGGRFTSSDPKELRNQLFGTPTKVRKSQNNDSFVIPELPPMQTNESPSITRRKLAFEEDEDEDEEEPGNDGLSLKSHSNKSITGTRNVDSDEYENHESDPTSEEEPLGVQESRSGRTKQNKAVGKPQSELKTAKALRKRGRIPNSLLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDPRIDHFIVSKMCSLMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDDQYNIWKKRIEMDLALTEPL
SIO_010081: YHR118C
subclass of: SO_0000673
so part of: YHR118C
location: complement(344321..345628)
location: region:344321-345628:-1
so has part: feature:344321-345628:-1:exon

NP_011986.1
type: Protein
SIO_000068: ncbiprotein

S000001160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:344321-345628:-1:exon

YHR119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KMT2
alternative label: YTX1
gene: SET1
locus tag: YHR119W
gene synonym: KMT2; YTX1
so part of: sequence
location: <346043..>349285
location: region:346043-349285:1
so has part: feature:346043-349285:1:exon
subclass of: SO_0000010

856519
type: Gene
SIO_000068: ncbigene

position:346043:1
position: 346043
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349285:1
position: 349285
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346043-349285:1:exon

YHR119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KMT2
alternative label: YTX1
gene: SET1
locus tag: YHR119W
gene synonym: KMT2; YTX1
product: histone methyltransferase SET1
transcript id: NM_001179249.1
SIO_010081: YHR119W
subclass of: SO_0000673
so part of: YHR119W
location: <346043..>349285
location: region:346043-349285:1
so has part: feature:346043-349285:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346043-349285:1:exon

YHR119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KMT2
alternative label: YTX1
gene: SET1
locus tag: YHR119W
gene synonym: KMT2; YTX1
EC number: 2.1.1.354
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16787775|PMID:28483910]
experiment: EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16959218]
experiment: EXISTENCE:genetic interaction:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16143104]
experiment: EXISTENCE:genetic interaction:GO:0035066 positive regulation of histone acetylation [PMID:19822662]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27325136]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990|PMID:9398665|PMID:27911222]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:16787775]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16959218]
experiment: EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16143104]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17150765]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:9398665]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11752412|PMID:9398665|PMID:9988274|PMID:11805083]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:32290544]
experiment: EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11752412|PMID:11805083|PMID:12845608]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27325136]
experiment: EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:27325136]
experiment: EXISTENCE:mutant phenotype:GO:1903341 regulation of meiotic DNA double-strand break formation [PMID:23246437]
experiment: EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11742990|PMID:11752412]
note: Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain
codon start: 1
product: histone methyltransferase SET1
translation: MSNYYRRAHASSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRRYNDDRPHSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSNVHNTLASSSGSLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQDGQFKFKIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQKLQENLKKAKEKEAENEKAKELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN
SIO_010081: YHR119W
subclass of: SO_0000673
so part of: YHR119W
location: 346043..349285
location: region:346043-349285:1
so has part: feature:346043-349285:1:exon

NP_011987.1
type: Protein
SIO_000068: ncbiprotein

S000001161
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346043-349285:1:exon

YHR120W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSH1
locus tag: YHR120W
so part of: sequence
location: <349574..>352453
location: region:349574-352453:1
so has part: feature:349574-352453:1:exon
subclass of: SO_0000010

856520
type: Gene
SIO_000068: ncbigene

position:349574:1
position: 349574
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352453:1
position: 352453
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349574-352453:1:exon

YHR120W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSH1
locus tag: YHR120W
product: mismatch repair ATPase MSH1
transcript id: NM_001179250.1
SIO_010081: YHR120W
subclass of: SO_0000673
so part of: YHR120W
location: <349574..>352453
location: region:349574-352453:1
so has part: feature:349574-352453:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349574-352453:1:exon

YHR120W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSH1
locus tag: YHR120W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15611870|PMID:7961998|PMID:16823961|PMID:14576278|PM ID:24769239]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:7961999]
experiment: EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:7961998]
experiment: EXISTENCE:direct assay:GO:0032139 dinucleotide insertion or deletion binding [PMID:7961998]
experiment: EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:1334021]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1334021]
experiment: EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:15611870]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15611870|PMID:1334021]
experiment: EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:1334021]
note: DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
codon start: 1
product: mismatch repair ATPase MSH1
translation: MKHFFRLPTAFRPISRVSLRYSSTDTAQPKISKLKISFNKISESNSEKKDNLGSIDTRNCLSTQQDDKLSSTEPSKASLPPSLQYVRDLMDLYKDHVVLTQMGSFYELYFEQAIRYAPELNISLTNRAYSHGKVPFAGFPVHQLSRHLKMLVNNCGYSVTIAEQFKKKDVADNEANKFYRRVTRIVTPGTFIDEAFENLRENTYLLNIEFPENCMSQVADTSLKVGICWCDVSTGEIFVQQVYLRDLVSAITRIQPKEILLDERLLEFHIESGTWYPELVELKKFFIKYQKMPSQHRTIESFYGLFNLGGKEATERQLKIQFQTFTQKELAALRNTLIYVSNHLPDFSINFQIPQRQLATAIMQIDSRTSTALELHSTVRDNNKKGSLLSSIRRTVTPSGTRLLSQWLSGPSLDLKEIKKRQKIVAFFKDNRDITETLRTMLKKVNDLSRILQKFSFGRGEALELIQMARSLEVSREIRKYLLNNTSLMKATLKSQITQLTESLNFEKNLIDDILKFLNEEELAKSQDAKQNADVTRMLDIDVKDKKESNKDEIFELRDFIVNPSFNTKLRKLHDTYQGVWQKKTEYNALLKGFFVGDLGAKTFTLKERQNGEYALHVTGTASSLKKIDELISKSTEYHGSCFHILQKSSQTRWLSHKIWTDLGHELELLNLKIRNEEANIIDLFKRKFIDRSNEVRQVATTLGYLDTLSSFAVLANERNLVCPKVDESNKLEVVNGRHLMVEEGLSARSLETFTANNCELAKDNLWVITGPNMGGKSTFLRQNAIIVILAQIGCFVPCSKARVGIVDKLFSRVGSADDLYNEMSTFMVEMIETSFILQGATERSLAILDEIGRGTSGKEGISIAYATLKYLLENNQCRTLFATHFGQELKQIIDNKCSKGMSEKVKFYQSGITDLGGNNFCYNHKLKPGICTKSDAIRVAELAGFPMEALKEAREILG
SIO_010081: YHR120W
subclass of: SO_0000673
so part of: YHR120W
location: 349574..352453
location: region:349574-352453:1
so has part: feature:349574-352453:1:exon

NP_011988.1
type: Protein
SIO_000068: ncbiprotein

S000001162
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349574-352453:1:exon

YHR121W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LSM12
locus tag: YHR121W
so part of: sequence
location: <352756..>353319
location: region:352756-353319:1
so has part: feature:352756-353319:1:exon
subclass of: SO_0000010

856521
type: Gene
SIO_000068: ncbigene

position:352756:1
position: 352756
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:353319:1
position: 353319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352756-353319:1:exon

YHR121W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LSM12
locus tag: YHR121W
product: Lsm12p
transcript id: NM_001179251.1
SIO_010081: YHR121W
subclass of: SO_0000673
so part of: YHR121W
location: <352756..>353319
location: region:352756-353319:1
so has part: feature:352756-353319:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:352756-353319:1:exon

YHR121W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LSM12
locus tag: YHR121W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:20368989|PMID:26777405]
experiment: EXISTENCE:physical interaction:GO:0016070 RNA metabolic process [PMID:16702403]
note: hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Lsm12p
translation: MSVSLEQTLGFRIKVTNVLDVVTEGRLYSFNSSNNTLTIQTTKKNQSPQNFKVIKCTFIKHLEVIGDKPSFNSFKKQQIKPSYVNVERVEKLLKESVIASKKKELLRGKGVSAEGQFIFDQIFKTIGDTKWVAKDIIILDDVKVQPPYKVEDIKVLHEGSNQSITLIQRIVERSWEQLEQDDGRKGG
SIO_010081: YHR121W
subclass of: SO_0000673
so part of: YHR121W
location: 352756..353319
location: region:352756-353319:1
so has part: feature:352756-353319:1:exon

NP_011989.1
type: Protein
SIO_000068: ncbiprotein

S000001163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:352756-353319:1:exon

YHR122W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CIA2
locus tag: YHR122W
so part of: sequence
location: <353625..>354320
location: region:353625-354320:1
so has part: feature:353625-354320:1:exon
subclass of: SO_0000010

856522
type: Gene
SIO_000068: ncbigene

position:353625:1
position: 353625
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:354320:1
position: 354320
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353625-354320:1:exon

YHR122W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CIA2
locus tag: YHR122W
product: iron-sulfur cluster assembly protein CIA2
transcript id: NM_001179252.1
SIO_010081: YHR122W
subclass of: SO_0000673
so part of: YHR122W
location: <353625..>354320
location: region:353625-354320:1
so has part: feature:353625-354320:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:353625-354320:1:exon

YHR122W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CIA2
locus tag: YHR122W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0097361 CIA complex [PMID:22678362]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:22678362]
note: Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
codon start: 1
product: iron-sulfur cluster assembly protein CIA2
translation: MSEFLNENPDILEENQLPTRKEDSTKDLLLGGFSNEATLERRSLLLKIDHSLKSQVLQDIEVLDKLLSIRIPPELTSDEDSLPAESEDESVAGGGKEEEEPDLIDAQEIYDLIAHISDPEHPLSLGQLSVVNLEDIDVHDSGNQNEMAEVVIKITPTITHCSLATLIGLGIRVRLERSLPPRFRITILLKKGTHDSENQVNKQLNDKERVAAACENEQLLGVVSKMLVTCK
SIO_010081: YHR122W
subclass of: SO_0000673
so part of: YHR122W
location: 353625..354320
location: region:353625-354320:1
so has part: feature:353625-354320:1:exon

NP_011990.1
type: Protein
SIO_000068: ncbiprotein

S000001164
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:353625-354320:1:exon

YHR123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EPT1
locus tag: YHR123W
so part of: sequence
location: <354815..>356081
location: region:354815-356081:1
so has part: feature:354815-356081:1:exon
subclass of: SO_0000010

856523
type: Gene
SIO_000068: ncbigene

position:354815:1
position: 354815
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356081:1
position: 356081
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354815-356081:1:exon

YHR123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EPT1
locus tag: YHR123W
product: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
transcript id: NM_001179253.1
SIO_010081: YHR123W
subclass of: SO_0000673
so part of: YHR123W
location: join(<354815..354864,354956..>356081)
location: region:354815-356081:1
so has part: feature:354815-354864:1:exon
so has part: feature:354956-356081:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:354815-354864:1:exon

position:354864:1
position: 354864
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:354956-356081:1:exon

position:354956:1
position: 354956
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EPT1
locus tag: YHR123W
EC number: 2.7.8.1
EC number: 2.7.8.2
experiment: EXISTENCE:direct assay:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:2848840]
experiment: EXISTENCE:direct assay:GO:0004307 ethanolaminephosphotransferase activity [PMID:2848840]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:2848840]
experiment: EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2848840]
experiment: EXISTENCE:mutant phenotype:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:2848840]
experiment: EXISTENCE:mutant phenotype:GO:0004307 ethanolaminephosphotransferase activity [PMID:2848840]
experiment: EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:2848840]
experiment: EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2848840]
note: sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
codon start: 1
product: bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase
translation: MGYFVPDSHIENLKSYKYQSEDRSLVSKYFLKPFWQRFCHIFPTWMAPNIITLSGFAFIVINVLTVFYYDPNLNTDTPRWTYFSYALGVFLYQTFDGCDGVHARRINQSGPLGELFDHSIDAINSTLSIFIFASETGMGFSYNLMLSQFAMLTNFYLSTWEEYHTHTLYLSEFSGPVEGILIVCVSLILTGIYGKQVIWHTYLFTITVGDKVIDVDTLDIVFSLAVFGLVMNALSAKRNVDKYYRNSTSSANNITQIEQDSAIKGLLPFFAYYASIALLVWMQPSFITLSFILSVGFTGAFTVGRIIVCHLTKQSFPMFNAPMLIPLCQIVLYKICLSLWGIESNKIVFALSWLGFGLSLGVHIMFMNDIIHEFTEYLDVYALSIKRSKLT
SIO_010081: YHR123W
subclass of: SO_0000673
so part of: YHR123W
location: join(354815..354864,354956..356081)
location: region:354815-356081:1
so has part: feature:354815-354864:1:exon
so has part: feature:354956-356081:1:exon

NP_011991.1
type: Protein
SIO_000068: ncbiprotein

S000001165
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:354815-354864:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:354956-356081:1:exon

YHR124W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NDT80
locus tag: YHR124W
so part of: sequence
location: <356561..>358444
location: region:356561-358444:1
so has part: feature:356561-358444:1:exon
subclass of: SO_0000010

856524
type: Gene
SIO_000068: ncbigene

position:356561:1
position: 356561
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:358444:1
position: 358444
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:356561-358444:1:exon

YHR124W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NDT80
locus tag: YHR124W
product: transcription factor NDT80
transcript id: NM_001179254.1
SIO_010081: YHR124W
subclass of: SO_0000673
so part of: YHR124W
location: <356561..>358444
location: region:356561-358444:1
so has part: feature:356561-358444:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:356561-358444:1:exon

YHR124W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NDT80
locus tag: YHR124W
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11035815]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9660952]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:9660952]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9660952]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8524222]
note: Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
codon start: 1
product: transcription factor NDT80
translation: MNEMENTDPVLQDDLVSKYERELSTEQEEDTPVILTQLNEDGTTSNYFDKRKLKIAPRSTLQFKVGPPFELVRDYCPVVESHTGRTLDLRIIPRIDRGFDHIDEEWVGYKRNYFTLVSTFETANCDLDTFLKSSFDLLVEDSSVESRLRVQYFAIKIKAKNDDDDTEINLVQHTAKRDKGPQFCPSVCPLVPSPLPKHQIIREASNVRNITKMKKYDSTFYLHRDHVNYEEYGVDSLLFSYPEDSIQKVARYERVQFASSISVKKPSQQNKHFSLHVILGAVVDPDTFHGENPGIPYDELALKNGSKGMFVYLQEMKTPPLIIRGRSPSNYASSQRITVRTPSSVNSSQNSTKRKMPSMAQPLNESCLNARPSKRRSKVALGAPNSGASISPIKSRQSTPMEASKENEDPFFRPNKRVETLEHIQNKLGALKNQCPDSSLKYPSSSSRGMEGCLEKEDLVYSSSFSVNMKQIELKPARSFEHENIFKVGSLAFKKINELPHENYDITIEKKSMEQNYLRPEIGSRSECKTSYGNELSLSNISFSILPNSAENFHLETALFPATEEDVPRTFSRILETGSFQNYYQKMDAENADRVYSKGVKLIASGTLPSGIFNREELFEEDSFYKY
SIO_010081: YHR124W
subclass of: SO_0000673
so part of: YHR124W
location: 356561..358444
location: region:356561-358444:1
so has part: feature:356561-358444:1:exon

NP_011992.1
type: Protein
SIO_000068: ncbiprotein

S000001166
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:356561-358444:1:exon

YNCH0010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0010C
so part of: sequence
location: complement(358478..358569)
location: region:358478-358569:-1
so has part: feature:358478-358569:-1:exon
subclass of: SO_0000663

856525
type: Gene
SIO_000068: ncbigene

position:358478:-1
position: 358478
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:358569:-1
position: 358569
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358478-358569:-1:exon

YNCH0010C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0010C
product: tRNA-Phe
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0010C
subclass of: SO_0000673
so part of: YNCH0010C
location: complement(join(358478..358513,358533..358569))
location: region:358478-358569:-1
so has part: feature:358533-358569:-1:exon
so has part: feature:358478-358513:-1:exon

S000006567
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:358533-358569:-1:exon

position:358533:-1
position: 358533
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:358478-358513:-1:exon

position:358513:-1
position: 358513
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(358672..358850)
location: region:358672-358850:-1
so has part: feature:358672-358850:-1:region

S000006996
type: SGD
SIO_000068: sgd

position:358672:-1
position: 358672
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:358850:-1
position: 358850
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358672-358850:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(358850..359067)
location: region:358850-359067:-1
so has part: feature:358850-359067:-1:region

S000007005
type: SGD
SIO_000068: sgd

position:359067:-1
position: 359067
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358850-359067:-1:region

YHR125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR125W
so part of: sequence
location: <358858..>359163
location: region:358858-359163:1
so has part: feature:358858-359163:1:exon
subclass of: SO_0000010

856526
type: Gene
SIO_000068: ncbigene

position:358858:1
position: 358858
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:359163:1
position: 359163
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358858-359163:1:exon

YHR125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR125W
product: uncharacterized protein
transcript id: NM_001348824.1
SIO_010081: YHR125W
subclass of: SO_0000673
so part of: YHR125W
location: <358858..>359163
location: region:358858-359163:1
so has part: feature:358858-359163:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:358858-359163:1:exon

YHR125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR125W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MINAIMIGSCQTFNTILCNISMNNYHSNVQLSSIRLQYCMKYSLTFSLFYNSTVTLKRQTWRTLIYDVCIWLDTAVIRNIIIRQLVVTLVVYYHMVCKNIT
SIO_010081: YHR125W
subclass of: SO_0000673
so part of: YHR125W
location: 358858..359163
location: region:358858-359163:1
so has part: feature:358858-359163:1:exon

NP_001335740.1
type: Protein
SIO_000068: ncbiprotein

S000001167
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:358858-359163:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 359079..359372
location: region:359079-359372:1
so has part: feature:359079-359372:1:region

S000007008
type: SGD
SIO_000068: sgd

position:359079:1
position: 359079
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:359372:1
position: 359372
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359079-359372:1:region

YHR126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ANS1
locus tag: YHR126C
so part of: sequence
location: complement(<359702..>360181)
location: region:359702-360181:-1
so has part: feature:359702-360181:-1:exon
subclass of: SO_0000010

856527
type: Gene
SIO_000068: ncbigene

position:359702:-1
position: 359702
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360181:-1
position: 360181
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359702-360181:-1:exon

YHR126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ANS1
locus tag: YHR126C
product: Ans1p
transcript id: NM_001179256.1
SIO_010081: YHR126C
subclass of: SO_0000673
so part of: YHR126C
location: complement(<359702..>360181)
location: region:359702-360181:-1
so has part: feature:359702-360181:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359702-360181:-1:exon

YHR126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ANS1
locus tag: YHR126C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p
codon start: 1
product: Ans1p
translation: MKCTLVSTLFAITNILVAHAQVSNSSDTLDVQFANSTNSYIEGKFNSTDEAFNSSASWSLAAQQKKISNAAVYDVGGWNGSLYRSNRSAVADHQPGKKQDAAISQISDGQIQATASGPETTAATTPSSTANVSVYEGAGMKVESKNMGYIVGVAALLFL
SIO_010081: YHR126C
subclass of: SO_0000673
so part of: YHR126C
location: complement(359702..360181)
location: region:359702-360181:-1
so has part: feature:359702-360181:-1:exon

NP_011994.1
type: Protein
SIO_000068: ncbiprotein

S000001168
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359702-360181:-1:exon

YHR127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR127W
so part of: sequence
location: <360913..>361644
location: region:360913-361644:1
so has part: feature:360913-361644:1:exon
subclass of: SO_0000010

856528
type: Gene
SIO_000068: ncbigene

position:360913:1
position: 360913
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361644:1
position: 361644
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360913-361644:1:exon

YHR127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR127W
product: uncharacterized protein
transcript id: NM_001179257.1
SIO_010081: YHR127W
subclass of: SO_0000673
so part of: YHR127W
location: <360913..>361644
location: region:360913-361644:1
so has part: feature:360913-361644:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360913-361644:1:exon

YHR127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR127W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]
experiment: EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:18194531]
note: hypothetical protein; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
codon start: 1
product: uncharacterized protein
translation: MARNRTTSKKNVQSKRLIDRVVPMDKIKKVGVAKKKTVEHTKEGFSVVNGKLVSSNDVGVLLREAQGAIDKRTNVSQRNRKKGIKNNRPHKDINSSPDWGNAHRGTDWQSEKANGMNRAKNSRNFTTNIKLQRQHFGEEIQGGSQLVISTNSDASDKLLMLFNLTLGVNQENLKNVLENISQVQIAQIRVRDLPSGSATAKVRLAYPTTQSLEKVRKLFHGALVDGRRIQVVIASDESSHLSY
SIO_010081: YHR127W
subclass of: SO_0000673
so part of: YHR127W
location: 360913..361644
location: region:360913-361644:1
so has part: feature:360913-361644:1:exon

NP_011995.1
type: Protein
SIO_000068: ncbiprotein

S000001169
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360913-361644:1:exon

YHR128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FUR1
locus tag: YHR128W
so part of: sequence
location: <362115..>362765
location: region:362115-362765:1
so has part: feature:362115-362765:1:exon
subclass of: SO_0000010

856529
type: Gene
SIO_000068: ncbigene

position:362115:1
position: 362115
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:362765:1
position: 362765
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362115-362765:1:exon

YHR128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FUR1
locus tag: YHR128W
product: uracil phosphoribosyltransferase
transcript id: NM_001179258.1
SIO_010081: YHR128W
subclass of: SO_0000673
so part of: YHR128W
location: <362115..>362765
location: region:362115-362765:1
so has part: feature:362115-362765:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:362115-362765:1:exon

YHR128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FUR1
locus tag: YHR128W
EC number: 2.4.2.9
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:2189783]
experiment: EXISTENCE:direct assay:GO:0004845 uracil phosphoribosyltransferase activity [PMID:2189783]
experiment: EXISTENCE:direct assay:GO:0008655 pyrimidine-containing compound salvage [PMID:2189783]
note: Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
codon start: 1
product: uracil phosphoribosyltransferase
translation: MSSEPFKNVYLLPQTNQLLGLYTIIRNKNTTRPDFIFYSDRIIRLLVEEGLNHLPVQKQIVETDTNENFEGVSFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISERYVFLLDPMLATGGSAIMATEVLIKRGVKPERIYFLNLICSKEGIEKYHAAFPEVRIVTGALDRGLDENKYLVPGLGDFGDRYYCV
SIO_010081: YHR128W
subclass of: SO_0000673
so part of: YHR128W
location: 362115..362765
location: region:362115-362765:1
so has part: feature:362115-362765:1:exon

NP_011996.2
type: Protein
SIO_000068: ncbiprotein

S000001170
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:362115-362765:1:exon

YHR129C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACT5
gene: ARP1
locus tag: YHR129C
gene synonym: ACT5
so part of: sequence
location: complement(<362999..>364153)
location: region:362999-364153:-1
so has part: feature:362999-364153:-1:exon
subclass of: SO_0000010

856530
type: Gene
SIO_000068: ncbigene

position:362999:-1
position: 362999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:364153:-1
position: 364153
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362999-364153:-1:exon

YHR129C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACT5
gene: ARP1
locus tag: YHR129C
gene synonym: ACT5
product: actin-related protein 1
transcript id: NM_001179259.1
SIO_010081: YHR129C
subclass of: SO_0000673
so part of: YHR129C
location: complement(<362999..>364153)
location: region:362999-364153:-1
so has part: feature:362999-364153:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:362999-364153:-1:exon

YHR129C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACT5
gene: ARP1
locus tag: YHR129C
gene synonym: ACT5
experiment: EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9658168]
experiment: EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:9658168]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:11285282]
experiment: EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:8069915]
experiment: EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:8069915]
note: Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin
codon start: 1
product: actin-related protein 1
translation: MDQLSDSYALYNQPVVIDNGSGIIKAGFSGEERPKALEYCLVGNTKYDKVMLEGLQGDTFIGNNAQKLRGLLKLRYPIKHGVVEDWDSMELIWSYVLNEVLQLQNIGEHPLLITEAPMNPLKNREQMAQVLFETFDVSALYVSNPAVLSLYASGRTTGCVVDCGEGYCSTVPIYDGFALPASMMRMDIGGADITEQLQFQLRKSAGVSLFSSSEREIVRTMKEKVCYLAKNIKKEEEKYLQGTQDLISTFKLPDGRCIEVGNDRYRAPEILFSPQIIGLGYDGLSDMCMQSIWKVDLDLRKPLLSSIILSGGTTTLKGFGDRMLWDLEALTKGTSKIKIIAPSERKYTTWIGGSILTGLSTFQRLWTKKSDWLEDSTRVYSNLM
SIO_010081: YHR129C
subclass of: SO_0000673
so part of: YHR129C
location: complement(362999..364153)
location: region:362999-364153:-1
so has part: feature:362999-364153:-1:exon

NP_011997.1
type: Protein
SIO_000068: ncbiprotein

S000001171
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:362999-364153:-1:exon

YHR130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR130C
so part of: sequence
location: complement(<364965..>365300)
location: region:364965-365300:-1
so has part: feature:364965-365300:-1:exon
subclass of: SO_0000010

856531
type: Gene
SIO_000068: ncbigene

position:364965:-1
position: 364965
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:365300:-1
position: 365300
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364965-365300:-1:exon

YHR130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR130C
product: uncharacterized protein
transcript id: NM_001348825.1
SIO_010081: YHR130C
subclass of: SO_0000673
so part of: YHR130C
location: complement(<364965..>365300)
location: region:364965-365300:-1
so has part: feature:364965-365300:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:364965-365300:-1:exon

YHR130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR130C
note: hypothetical protein; conserved among S. cerevisiae strains; YHR130C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MTKSIYIIIGYMLHDEEFFYFFFISFYTLWIVFFLLHLSFFSTLSFGIFHDFDTDVYIKVGNYILHFLELSKNSNLLKNSSEMLKHFRLASLMYMYVYTQMICPSLLGIRN
SIO_010081: YHR130C
subclass of: SO_0000673
so part of: YHR130C
location: complement(364965..365300)
location: region:364965-365300:-1
so has part: feature:364965-365300:-1:exon

NP_001335741.1
type: Protein
SIO_000068: ncbiprotein

S000001172
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:364965-365300:-1:exon

YHR131C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR131C
so part of: sequence
location: complement(<365340..>367892)
location: region:365340-367892:-1
so has part: feature:365340-367892:-1:exon
subclass of: SO_0000010

856532
type: Gene
SIO_000068: ncbigene

position:365340:-1
position: 365340
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:367892:-1
position: 367892
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:365340-367892:-1:exon

YHR131C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR131C
product: uncharacterized protein
transcript id: NM_001179261.1
SIO_010081: YHR131C
subclass of: SO_0000673
so part of: YHR131C
location: complement(<365340..>367892)
location: region:365340-367892:-1
so has part: feature:365340-367892:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:365340-367892:-1:exon

YHR131C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR131C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MALPIEGKLSMANNRIERLKSPSSSSTCSMDEVLITSSNNSSSICLETMRQLPREGVSGQINIIKETAASSSSHAALFIKQDLYEHIDPLPAYPPSYDLVNPNKEVRFPIFGDTAPCPKSSLPPLYAPAVYELTLISLKLERLSPYEISSNRSWRNFIIEINSTQLNFYHIDESLTKHIRNYSSGETKSEKEDRIHSDLVHRSDQSQHLHHRLFTLPTRSASEFKKADQERISYRVKRDRSRYLTDEALYKSFTLQNARFGIPTDYTKKSFVLRMSCESEQFLLRFSHIDDMIDWSMYLSIGISVSLDLEVREYPDYRIVPRRRRRRRRRRRRRRHTHRSESSMGSFSQRFIRSNSRPDLIQRYSTGSSTNNNTTIRERSNTFTAGLLDHYCTGLSKTPTEALISSAASGESSDNSTLGSTRSLSGCSASRSIASRSLKFKIKNFFRPKNSSRTEKLHRLRSNSSNLNSVIETEEDDEHHESSGGDHPEPGVPVNTTIKVERPMHRNRAISMPQRQSLRRAISEEVVPIKFPNSTVGESVHSPSPIEHLSVDGCEIMLQSQNAVMKEELRSVASNLVANERDEASIRPKPQSSSIYLSGLAPNGESATDLSQSSRSLCLTNRDAEINDDESATETDEDENDGETDEYAGDDTNDDTDDSNIGYAYGSESDYSCLIEERIRNRRRASSTLSCFSNIPYGTDDIKWKPAIKEISRRRYLRDSLKCIKPFLDSNDCLGKVIYIPVSGPTFETSNKIHFSNRQSLQKQKNHFLKGFIVGPTALIELNCKNKNAIVGTTKDAEDHGEDDGDGDDGEDDDDDDDDDDDDDDDEDDDDDDDDDDDDDDDDDDGQITA
SIO_010081: YHR131C
subclass of: SO_0000673
so part of: YHR131C
location: complement(365340..367892)
location: region:365340-367892:-1
so has part: feature:365340-367892:-1:exon

NP_011999.2
type: Protein
SIO_000068: ncbiprotein

S000001173
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:365340-367892:-1:exon

YHR132C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ECM14
locus tag: YHR132C
so part of: sequence
location: complement(<368502..>369794)
location: region:368502-369794:-1
so has part: feature:368502-369794:-1:exon
subclass of: SO_0000010

856533
type: Gene
SIO_000068: ncbigene

position:368502:-1
position: 368502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:369794:-1
position: 369794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368502-369794:-1:exon

YHR132C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ECM14
locus tag: YHR132C
product: putative metallocarboxypeptidase
transcript id: NM_001179262.1
SIO_010081: YHR132C
subclass of: SO_0000673
so part of: YHR132C
location: complement(<368502..>369794)
location: region:368502-369794:-1
so has part: feature:368502-369794:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368502-369794:-1:exon

YHR132C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ECM14
locus tag: YHR132C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]
note: Conserved fungal protein with similarity to zinc carboxypeptidases; in some strains required for normal cell wall assembly
codon start: 1
product: putative metallocarboxypeptidase
translation: MLHMNSLWGCFLFVLLAVTGAVQGLQEDYSEYAVYRFTSDNYSTLVRDVIAPLTDDYDVWTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMAREQAVFENDYDFFFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITGGIHAREWISVSTVCWALYQLLNRYGSSKKETKYLDDLDFLVIPVFNPDGYAYTWSHDRLWRKNRQRTHVPQCLGIDIDHSFGFQWEKAHTHACSEEYSGETPFEAWEASAWYKYINETKGDYKIYGYIDMHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGRNYDVISACKDRGSDIFPGLGAGSALDFMYHHRAHWAFQLKLRDTGNHGFLLPPENIKPVGKETYAALKYFCDFLLDPEI
SIO_010081: YHR132C
subclass of: SO_0000673
so part of: YHR132C
location: complement(368502..369794)
location: region:368502-369794:-1
so has part: feature:368502-369794:-1:exon

NP_012000.1
type: Protein
SIO_000068: ncbiprotein

S000001174
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368502-369794:-1:exon

YHR132W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IGO2
locus tag: YHR132W-A
so part of: sequence
location: <370054..>370449
location: region:370054-370449:1
so has part: feature:370054-370449:1:exon
subclass of: SO_0000010

856534
type: Gene
SIO_000068: ncbigene

position:370054:1
position: 370054
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:370449:1
position: 370449
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370054-370449:1:exon

YHR132W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IGO2
locus tag: YHR132W-A
product: phosphatase regulator
transcript id: NM_001184441.1
SIO_010081: YHR132W-A
subclass of: SO_0000673
so part of: YHR132W-A
location: <370054..>370449
location: region:370054-370449:1
so has part: feature:370054-370449:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370054-370449:1:exon

YHR132W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IGO2
locus tag: YHR132W-A
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:28100785]
experiment: EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:20471941]
experiment: EXISTENCE:genetic interaction:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]
experiment: EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:23273919|PMID:20471941]
experiment: EXISTENCE:genetic interaction:GO:1905184 positive regulation of protein serine/threonine phosphatase activity [PMID:23861665]
note: Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication
codon start: 1
product: phosphatase regulator
translation: MSEDLSPTSSRVDLSNPHGFTKEGVDLSKLSPQELKLYKMYGKLPSKKDLLRHKMQDRQYFDSGDYALKKAGVIKSDDVIVNNSSNNLPVTNPSGLRESIIRRRMSSSSGGDSISRQGSISSGPPPRSPNK
SIO_010081: YHR132W-A
subclass of: SO_0000673
so part of: YHR132W-A
location: 370054..370449
location: region:370054-370449:1
so has part: feature:370054-370449:1:exon

NP_036194.1
type: Protein
SIO_000068: ncbiprotein

S000007496
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370054-370449:1:exon

YHR133C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSG1
locus tag: YHR133C
so part of: sequence
location: complement(<370722..>371597)
location: region:370722-371597:-1
so has part: feature:370722-371597:-1:exon
subclass of: SO_0000010

856535
type: Gene
SIO_000068: ncbigene

position:370722:-1
position: 370722
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371597:-1
position: 371597
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:370722-371597:-1:exon

YHR133C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSG1
locus tag: YHR133C
product: Nsg1p
transcript id: NM_001179263.1
SIO_010081: YHR133C
subclass of: SO_0000673
so part of: YHR133C
location: complement(<370722..>371597)
location: region:370722-371597:-1
so has part: feature:370722-371597:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:370722-371597:-1:exon

YHR133C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSG1
locus tag: YHR133C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16270032|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0016126 sterol biosynthetic process [PMID:16270032]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16270032]
experiment: EXISTENCE:physical interaction:GO:0016126 sterol biosynthetic process [PMID:16270032]
experiment: EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:16270032]
note: Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication
codon start: 1
product: Nsg1p
translation: MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN
SIO_010081: YHR133C
subclass of: SO_0000673
so part of: YHR133C
location: complement(370722..371597)
location: region:370722-371597:-1
so has part: feature:370722-371597:-1:exon

NP_012001.1
type: Protein
SIO_000068: ncbiprotein

S000001175
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:370722-371597:-1:exon

YHR134W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WSS1
locus tag: YHR134W
so part of: sequence
location: <371749..>372558
location: region:371749-372558:1
so has part: feature:371749-372558:1:exon
subclass of: SO_0000010

856536
type: Gene
SIO_000068: ncbigene

position:371749:1
position: 371749
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:372558:1
position: 372558
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:371749-372558:1:exon

YHR134W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WSS1
locus tag: YHR134W
product: metalloendopeptidase WSS1
transcript id: NM_001179264.1
SIO_010081: YHR134W
subclass of: SO_0000673
so part of: YHR134W
location: <371749..>372558
location: region:371749-372558:1
so has part: feature:371749-372558:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:371749-372558:1:exon

YHR134W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WSS1
locus tag: YHR134W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26349035]
experiment: EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:24998930]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:18336552]
experiment: EXISTENCE:direct assay:GO:0008237 metallopeptidase activity [PMID:26349035]
experiment: EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:26349035]
experiment: EXISTENCE:direct assay:GO:0019985 translesion synthesis [PMID:24998930]
experiment: EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:26349035]
experiment: EXISTENCE:direct assay:GO:0061665 SUMO ligase activity [PMID:26349035]
experiment: EXISTENCE:direct assay:GO:1990466 protein autosumoylation [PMID:26349035]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:15598824]
experiment: EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:11606525]
experiment: EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:24998930]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:24998930]
experiment: EXISTENCE:mutant phenotype:GO:0010224 response to UV-B [PMID:11606770|PMID:15598824]
experiment: EXISTENCE:mutant phenotype:GO:0010225 response to UV-C [PMID:11606770|PMID:15598824]
experiment: EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:24998930]
experiment: EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:32130911]
experiment: EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]
note: SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan
codon start: 1
product: metalloendopeptidase WSS1
translation: MKTEGIKSPSAKYHDMAGSQRIPHKNPHIQKVAVLQSKPNKEDALNLIKEIAHKVSYLMKENHFKVTNLVEFYPRDQRLLGMNVNHGSKIMLRLRCSTDEFQFLPMECIMGTMLHELTHNLFGPHDKKFYNKLDELIGRQWVIEQRGLYDTFLGNGQRLGGRANLRSNRYPMTGISTNTGIVRKRGKGVKLGSLHPEGISSIDRGNSPRELAAFAAERRYRDDRWCGETKNNKDQIISDNISSSLEVVILDDDDEVLPGDTLIEVIDLT
SIO_010081: YHR134W
subclass of: SO_0000673
so part of: YHR134W
location: 371749..372558
location: region:371749-372558:1
so has part: feature:371749-372558:1:exon

NP_012002.1
type: Protein
SIO_000068: ncbiprotein

S000001176
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:371749-372558:1:exon

YHR135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CKI2
gene: YCK1
locus tag: YHR135C
gene synonym: CKI2
so part of: sequence
location: complement(<372694..>374310)
location: region:372694-374310:-1
so has part: feature:372694-374310:-1:exon
subclass of: SO_0000010

856537
type: Gene
SIO_000068: ncbigene

position:372694:-1
position: 372694
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374310:-1
position: 374310
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372694-374310:-1:exon

YHR135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CKI2
gene: YCK1
locus tag: YHR135C
gene synonym: CKI2
product: serine/threonine protein kinase YCK1
transcript id: NM_001179265.1
SIO_010081: YHR135C
subclass of: SO_0000673
so part of: YHR135C
location: complement(<372694..>374310)
location: region:372694-374310:-1
so has part: feature:372694-374310:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372694-374310:-1:exon

YHR135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CKI2
gene: YCK1
locus tag: YHR135C
gene synonym: CKI2
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8474447]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:1627830|PMID:16622836|PMID:8034689]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:27630263]
experiment: EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:10198058]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10198058]
experiment: EXISTENCE:mutant phenotype:GO:0009749 response to glucose [PMID:14755054]
note: Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase YCK1
translation: MSMPIASTTLAVNNLTNINGNANFNVQANKQLHHQAVDSPARSSMTATTAANSNSNSSRDDSTIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQYDWMKLNDGRGWDLNINKKPNLHGYGHPNPPNEKSRKHRNKQLQMQQLQMQQLQQQQQQQQYAQKTEADMRNSQYKPKLDPTSYEAYQHQTQQKYLQEQQKRQQQQKLQEQQLQEQQLQQQQQQQQQLRATGQPPSQPQAQTQSQQFGARYQPQQQPSAALRTPEQHPNDDNSSLAASHKGFFQKLGCC
SIO_010081: YHR135C
subclass of: SO_0000673
so part of: YHR135C
location: complement(372694..374310)
location: region:372694-374310:-1
so has part: feature:372694-374310:-1:exon

NP_012003.1
type: Protein
SIO_000068: ncbiprotein

S000001177
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372694-374310:-1:exon

YHR136C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPL2
locus tag: YHR136C
so part of: sequence
location: complement(<374654..>375100)
location: region:374654-375100:-1
so has part: feature:374654-375100:-1:exon
subclass of: SO_0000010

856538
type: Gene
SIO_000068: ncbigene

position:374654:-1
position: 374654
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:375100:-1
position: 375100
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374654-375100:-1:exon

YHR136C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPL2
locus tag: YHR136C
product: Spl2p
transcript id: NM_001179266.1
SIO_010081: YHR136C
subclass of: SO_0000673
so part of: YHR136C
location: complement(<374654..>375100)
location: region:374654-375100:-1
so has part: feature:374654-375100:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:374654-375100:-1:exon

YHR136C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPL2
locus tag: YHR136C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:21143198]
note: Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm
codon start: 1
product: Spl2p
translation: MGTYTPLIYNIYNVHIWVFTESQGQIGQMSPRGKMETAVSQGQHKQLKDGHQHKGRKLSEEIASLLRLKECRRLNPASYYTPRRTSQSQSLSGSTFKEYNEYINEKDSSRAQRQNAAAVLSKLAHDFWENDCVIDEDIFEDSSDEEQS
SIO_010081: YHR136C
subclass of: SO_0000673
so part of: YHR136C
location: complement(374654..375100)
location: region:374654-375100:-1
so has part: feature:374654-375100:-1:exon

NP_012004.1
type: Protein
SIO_000068: ncbiprotein

S000001178
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374654-375100:-1:exon

YHR137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARO9
locus tag: YHR137W
so part of: sequence
location: <375709..>377250
location: region:375709-377250:1
so has part: feature:375709-377250:1:exon
subclass of: SO_0000010

856539
type: Gene
SIO_000068: ncbigene

position:375709:1
position: 375709
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:377250:1
position: 377250
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375709-377250:1:exon

YHR137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARO9
locus tag: YHR137W
product: aromatic-amino-acid:2-oxoglutarate transaminase
transcript id: NM_001179267.1
SIO_010081: YHR137W
subclass of: SO_0000673
so part of: YHR137W
location: <375709..>377250
location: region:375709-377250:1
so has part: feature:375709-377250:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:375709-377250:1:exon

YHR137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARO9
locus tag: YHR137W
EC number: 2.6.1.7
EC number: 2.6.1.57
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006571 tyrosine biosynthetic process [PMID:9491082]
experiment: EXISTENCE:genetic interaction:GO:0009094 L-phenylalanine biosynthetic process [PMID:9491082]
experiment: EXISTENCE:mutant phenotype:GO:0008793 aromatic-amino-acid:2-oxoglutarate aminotransferase activity [PMID:9491082]
experiment: EXISTENCE:mutant phenotype:GO:0009072 aromatic amino acid metabolic process [PMID:9491083]
experiment: EXISTENCE:mutant phenotype:GO:0036137 kynurenine aminotransferase activity [PMID:9491082]
note: Aromatic aminotransferase II; involved in tyrosine, phenylalanine, and methionine metabolism; involved with Aro8p in production of kynurenic acid to detoxify excess tryptophan
codon start: 1
product: aromatic-amino-acid:2-oxoglutarate transaminase
translation: MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS
SIO_010081: YHR137W
subclass of: SO_0000673
so part of: YHR137W
location: 375709..377250
location: region:375709-377250:1
so has part: feature:375709-377250:1:exon

NP_012005.1
type: Protein
SIO_000068: ncbiprotein

S000001179
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375709-377250:1:exon

YHR138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR138C
so part of: sequence
location: complement(<377355..>377699)
location: region:377355-377699:-1
so has part: feature:377355-377699:-1:exon
subclass of: SO_0000010

856540
type: Gene
SIO_000068: ncbigene

position:377355:-1
position: 377355
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:377699:-1
position: 377699
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:377355-377699:-1:exon

YHR138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR138C
product: uncharacterized protein
transcript id: NM_001179268.1
SIO_010081: YHR138C
subclass of: SO_0000673
so part of: YHR138C
location: complement(<377355..>377699)
location: region:377355-377699:-1
so has part: feature:377355-377699:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:377355-377699:-1:exon

YHR138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR138C
experiment: EXISTENCE:mutant phenotype:GO:0004866 endopeptidase inhibitor activity [PMID:9657146]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:9657146]
note: hypothetical protein; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MKASYLVLIFISIFSMAQASSLSSYIVTFPKTDNMATDQNSIIEDVKKYVVDIGGKITHEYSLIKGFTVDLPDSDQILDGLKERLSYIESEYGAKCNLEKDSEVHALNRDHLVA
SIO_010081: YHR138C
subclass of: SO_0000673
so part of: YHR138C
location: complement(377355..377699)
location: region:377355-377699:-1
so has part: feature:377355-377699:-1:exon

NP_012006.1
type: Protein
SIO_000068: ncbiprotein

S000001180
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:377355-377699:-1:exon

YHR139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPS100
locus tag: YHR139C
so part of: sequence
location: complement(<378219..>379199)
location: region:378219-379199:-1
so has part: feature:378219-379199:-1:exon
subclass of: SO_0000010

856541
type: Gene
SIO_000068: ncbigene

position:378219:-1
position: 378219
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:379199:-1
position: 379199
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379199:-1:exon

YHR139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPS100
locus tag: YHR139C
product: Sps100p
transcript id: NM_001179269.1
SIO_010081: YHR139C
subclass of: SO_0000673
so part of: YHR139C
location: complement(<378219..>379199)
location: region:378219-379199:-1
so has part: feature:378219-379199:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379199:-1:exon

YHR139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPS100
locus tag: YHR139C
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:3280971]
note: Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication
codon start: 1
product: Sps100p
translation: MKFTSVLAFFLATLTASATPLYKRQNVTSGGGTVPVIITGGPAVSGSQSNVTTTTLFNSTSTLNITQLYQIATQVNQTLQSESSSGIIIVTNWRSIETLSFFCSIVFNTSKTIVITENFLWGVPILSSSDAEGRGTLVAGRDKVVYSGVFPPYTVPVGVLSGQKNVQWFFDACEPTLIASNSTIRTQYSNFTSAQISSNASSGTNTSSSSSSPLVPIIYEEGYSQSLIQSLSSSIQGLVVVSSGTSHNSTVASWTSVDFPVVYASDGSSGHDGSGIGFISNTSIPQGAISAGYLSPIQAQTLLSIAIHNQVTSSSELQQIFPVSQQ
SIO_010081: YHR139C
subclass of: SO_0000673
so part of: YHR139C
location: complement(378219..379199)
location: region:378219-379199:-1
so has part: feature:378219-379199:-1:exon

NP_012007.1
type: Protein
SIO_000068: ncbiprotein

S000001181
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378219-379199:-1:exon

YNCH0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUT169
locus tag: YNCH0011W
so part of: sequence
location: 378254..379237
location: region:378254-379237:1
so has part: feature:378254-379237:1:exon
subclass of: SO_0000011

65052916
type: Gene
SIO_000068: ncbigene

position:378254:1
position: 378254
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:379237:1
position: 379237
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378254-379237:1:exon

YNCH0011W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: antisense_RNA
gene: SUT169
locus tag: YNCH0011W
product: SUT169
note: Antisense transcript; upregulates sporulation-specific gene SPS100 upon entry into starvation or sporulation; functions by changing relative expression of SPS100 mRNA isoforms from short, unstable transcript to long, stable species, suggesting novel mechanism of antisense-dependent gene regulation via mRNA isoform switching
transcript id: NR_172476.1
SIO_010081: YNCH0011W
subclass of: SO_0000673
so part of: YNCH0011W
location: 378254..379237
location: region:378254-379237:1
so has part: feature:378254-379237:1:exon

S000303809
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378254-379237:1:exon

YHR139C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR139C-A
so part of: sequence
location: complement(<380108..>380419)
location: region:380108-380419:-1
so has part: feature:380108-380419:-1:exon
subclass of: SO_0000010

856542
type: Gene
SIO_000068: ncbigene

position:380108:-1
position: 380108
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:380419:-1
position: 380419
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:380108-380419:-1:exon

YHR139C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR139C-A
product: uncharacterized protein
transcript id: NM_001348830.1
SIO_010081: YHR139C-A
subclass of: SO_0000673
so part of: YHR139C-A
location: complement(<380108..>380419)
location: region:380108-380419:-1
so has part: feature:380108-380419:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380108-380419:-1:exon

YHR139C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR139C-A
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MRSADFSNPRILSNLMSKSEKEKRAIIIFNCRLNKGLYVTSACVSRSVFRCCKQEPLIEFVSPKMIAFVQIDGRYLTKMLTCDIHVRKEAKEGRGYQQIHKLS
SIO_010081: YHR139C-A
subclass of: SO_0000673
so part of: YHR139C-A
location: complement(380108..380419)
location: region:380108-380419:-1
so has part: feature:380108-380419:-1:exon

NP_001335742.1
type: Protein
SIO_000068: ncbiprotein

S000003533
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380108-380419:-1:exon

YHR140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR140W
so part of: sequence
location: <380572..>381291
location: region:380572-381291:1
so has part: feature:380572-381291:1:exon
subclass of: SO_0000010

856543
type: Gene
SIO_000068: ncbigene

position:380572:1
position: 380572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:381291:1
position: 381291
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:380572-381291:1:exon

YHR140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR140W
product: uncharacterized protein
transcript id: NM_001179270.1
SIO_010081: YHR140W
subclass of: SO_0000673
so part of: YHR140W
location: <380572..>381291
location: region:380572-381291:1
so has part: feature:380572-381291:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:380572-381291:1:exon

YHR140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR140W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22842922|PMID:31945465]
note: Endoplasmic reticulum protein; may contribute to maintenance of ER and nuclear morphology; null mutant shows discontinuity in nuclear envelope, clustering of nuclear pores, and lacks cortical ER
codon start: 1
product: uncharacterized protein
translation: MMSCLVPTRFTLTLNTACLLTSTWGFVRATSVVLPPSLSKAGHKQFLTIISIIATIINNAVNISNYYIQRNNKMNLETKKKSDFISRHVTLPVSLVLESIVATVYWPLRLFFVNLIMHGVESTAKTPFPMTVDMAIHLYPILYLLADHYLSGSGTKFKLSNKHAWLIVTSLAFSYFQYLAFLIDAGQGQAYPYPFLDVNEPYKSIIFVVVATITWAYYVFYQKFPPKYIKKSAKKGDKN
SIO_010081: YHR140W
subclass of: SO_0000673
so part of: YHR140W
location: 380572..381291
location: region:380572-381291:1
so has part: feature:380572-381291:1:exon

NP_012009.1
type: Protein
SIO_000068: ncbiprotein

S000001182
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:380572-381291:1:exon

YNCH0012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR32
locus tag: YNCH0012W
so part of: sequence
location: 381540..381727
location: region:381540-381727:1
so has part: feature:381540-381727:1:exon
subclass of: SO_0000578

9164901
type: Gene
SIO_000068: ncbigene

position:381540:1
position: 381540
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:381727:1
position: 381727
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381540-381727:1:exon

YNCH0012W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR32
locus tag: YNCH0012W
product: SNR32
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0000454 snoRNA guided rRNA pseudouridine synthesis [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:9160748]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2191
transcript id: NR_132188.1
SIO_010081: YNCH0012W
subclass of: SO_0000673
so part of: YNCH0012W
location: 381540..381727
location: region:381540-381727:1
so has part: feature:381540-381727:1:exon

S000007297
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381540-381727:1:exon

YHR141C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAK18
gene: RPL42B
locus tag: YHR141C
gene synonym: MAK18
so part of: sequence
location: complement(<381990..>382751)
location: region:381990-382751:-1
so has part: feature:381990-382751:-1:exon
subclass of: SO_0000010

856544
type: Gene
SIO_000068: ncbigene

position:381990:-1
position: 381990
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382751:-1
position: 382751
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381990-382751:-1:exon

YHR141C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAK18
gene: RPL42B
locus tag: YHR141C
gene synonym: MAK18
product: ribosomal 60S subunit protein L42B
transcript id: NM_001179271.1
SIO_010081: YHR141C
subclass of: SO_0000673
so part of: YHR141C
location: complement(join(<381990..382306,382748..>382751))
location: region:381990-382751:-1
so has part: feature:382748-382751:-1:exon
so has part: feature:381990-382306:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:382748-382751:-1:exon

position:382748:-1
position: 382748
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:381990-382306:-1:exon

position:382306:-1
position: 382306
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR141C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAK18
gene: RPL42B
locus tag: YHR141C
gene synonym: MAK18
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L42B
translation: MVNVPKTRKTYCKGKTCRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVKCKTRAQLTLKRCKHFELGGEKKQKGQALQF
SIO_010081: YHR141C
subclass of: SO_0000673
so part of: YHR141C
location: complement(join(381990..382306,382748..382751))
location: region:381990-382751:-1
so has part: feature:382748-382751:-1:exon
so has part: feature:381990-382306:-1:exon

NP_012010.1
type: Protein
SIO_000068: ncbiprotein

S000001183
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:382748-382751:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:381990-382306:-1:exon

YHR142W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CHS7
locus tag: YHR142W
so part of: sequence
location: <383538..>384488
location: region:383538-384488:1
so has part: feature:383538-384488:1:exon
subclass of: SO_0000010

856545
type: Gene
SIO_000068: ncbigene

position:383538:1
position: 383538
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384488:1
position: 384488
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:383538-384488:1:exon

YHR142W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CHS7
locus tag: YHR142W
product: Chs7p
transcript id: NM_001179272.1
SIO_010081: YHR142W
subclass of: SO_0000673
so part of: YHR142W
location: <383538..>384488
location: region:383538-384488:1
so has part: feature:383538-384488:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:383538-384488:1:exon

YHR142W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CHS7
locus tag: YHR142W
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10366589]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:29405545|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10366589]
experiment: EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]
experiment: EXISTENCE:mutant phenotype:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:10366589]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]
note: hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress
codon start: 1
product: Chs7p
translation: MAFSDFAAICSKTPLPLCSVIKSKTHLILSNSTIIHDFDPLNLNVGVLPRCYARSIDLANTVIFDVGNAFINIGALGVILIILYNIRQKYTAIGRSEYLYFFQLTLLLIIFTLVVDCGVSPPGSGSYPYFVAIQIGLAGACCWALLIIGFLGFNLWEDGTTKSMLLVRGTSMLGFIANFLASILTFKAWITDHKVATMNASGMIVVVYIINAIFLFVFVICQLLVSLLVVRNLWVTGAIFLGLFFFVAGQVLVYAFSTQICEGFKHYLDGLFFGSICNVFTLMMVYKTWDMTTDDDLEFGVSVSKDGDVVYDNGFM
SIO_010081: YHR142W
subclass of: SO_0000673
so part of: YHR142W
location: 383538..384488
location: region:383538-384488:1
so has part: feature:383538-384488:1:exon

NP_012011.1
type: Protein
SIO_000068: ncbiprotein

S000001184
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:383538-384488:1:exon

YHR143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DSE2
locus tag: YHR143W
so part of: sequence
location: <385510..>386487
location: region:385510-386487:1
so has part: feature:385510-386487:1:exon
subclass of: SO_0000010

856546
type: Gene
SIO_000068: ncbigene

position:385510:1
position: 385510
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:386487:1
position: 386487
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:385510-386487:1:exon

YHR143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DSE2
locus tag: YHR143W
product: Dse2p
transcript id: NM_001179274.1
SIO_010081: YHR143W
subclass of: SO_0000673
so part of: YHR143W
location: <385510..>386487
location: region:385510-386487:1
so has part: feature:385510-386487:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:385510-386487:1:exon

YHR143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DSE2
locus tag: YHR143W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11309124]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11309124]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11309124]
note: Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; localizes in birth scars; expression is repressed by cAMP
codon start: 1
product: Dse2p
translation: MKFNFSTIFNILFFLFTLIEANSNGETVKLITSDGIVYSYAVYTKTLAPARVVVKTISYTTTRVYPITLANSVVSSTTEKITEVSTVSASEQVSATQTNSLVSTSTVSTISPTISSGSSTSSSSTYDIESSQSIESSGTSSATAEPSASSGFRLTSSSAFVSSTAPFSSQLSSSSSSETSSSSFSTSSSSAPLSLTSSSSSSSSFATIITLAPSSSKSGNSQLTLASSSSTSAVESSQTGSTIARTTSTLVPSSSVDTTSRATTSMPLESSSTQSISVSSSDGTCYVFYDDDDYYSTVYLTNPSQSVDAATTITSTNTIYATVTI
SIO_010081: YHR143W
subclass of: SO_0000673
so part of: YHR143W
location: 385510..386487
location: region:385510-386487:1
so has part: feature:385510-386487:1:exon

NP_012012.1
type: Protein
SIO_000068: ncbiprotein

S000001186
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:385510-386487:1:exon

YHR143W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPB12
gene: RPC10
locus tag: YHR143W-A
gene synonym: RPB12
so part of: sequence
location: <387233..>387445
location: region:387233-387445:1
so has part: feature:387233-387445:1:exon
subclass of: SO_0000010

856547
type: Gene
SIO_000068: ncbigene

position:387233:1
position: 387233
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:387445:1
position: 387445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387233-387445:1:exon

YHR143W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPB12
gene: RPC10
locus tag: YHR143W-A
gene synonym: RPB12
product: DNA-directed RNA polymerase core subunit RPC10
transcript id: NM_001179273.1
SIO_010081: YHR143W-A
subclass of: SO_0000673
so part of: YHR143W-A
location: <387233..>387445
location: region:387233-387445:1
so has part: feature:387233-387445:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387233-387445:1:exon

YHR143W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPB12
gene: RPC10
locus tag: YHR143W-A
gene synonym: RPB12
experiment: EXISTENCE:direct assay:GO:0001054 RNA polymerase I activity [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0001055 RNA polymerase II activity [PMID:8288647]
experiment: EXISTENCE:direct assay:GO:0001056 RNA polymerase III activity [PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:1748681]
experiment: EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:1748681|PMID:3905793]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:9837969|PMID:1748681]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
experiment: EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:1748681]
experiment: EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]
experiment: EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:10531351]
experiment: EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:10531351]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:10531351]
experiment: EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:10531351]
note: RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress; localizes to the peroxisome in a Pex5p-dependent manner
codon start: 1
product: DNA-directed RNA polymerase core subunit RPC10
translation: MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR
SIO_010081: YHR143W-A
subclass of: SO_0000673
so part of: YHR143W-A
location: 387233..387445
location: region:387233-387445:1
so has part: feature:387233-387445:1:exon

NP_012013.1
type: Protein
SIO_000068: ncbiprotein

S000001185
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387233-387445:1:exon

YHR144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DCD1
locus tag: YHR144C
so part of: sequence
location: complement(<387788..>388726)
location: region:387788-388726:-1
so has part: feature:387788-388726:-1:exon
subclass of: SO_0000010

856548
type: Gene
SIO_000068: ncbigene

position:387788:-1
position: 387788
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388726:-1
position: 388726
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387788-388726:-1:exon

YHR144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DCD1
locus tag: YHR144C
product: deoxycytidine monophosphate deaminase
transcript id: NM_001179275.1
SIO_010081: YHR144C
subclass of: SO_0000673
so part of: YHR144C
location: complement(<387788..>388726)
location: region:387788-388726:-1
so has part: feature:387788-388726:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387788-388726:-1:exon

YHR144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DCD1
locus tag: YHR144C
EC number: 3.5.4.12
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004132 dCMP deaminase activity [PMID:3023902]
experiment: EXISTENCE:mutant phenotype:GO:0006226 dUMP biosynthetic process [PMID:6373725]
experiment: EXISTENCE:mutant phenotype:GO:0006231 dTMP biosynthetic process [PMID:6373725]
note: Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated
codon start: 1
product: deoxycytidine monophosphate deaminase
translation: MLIGVSGTKFCGCEDVINMLVDHFHFELLNHLDNPEEILDYATKNYTKNSVIFLEKLSLLEKLEKRPFFVHLSIDAPVTTRVALYRKTTQAESLSLEQIIQAIDQHDFQPEGIKLREKSHLRFKIVNEDRRGRRQSLINNITTQLKILDDKEKQMAPLMRPSWDSYFMKLATLAASRSNCMKRRVGCVIVRECRVIATGYNGTPRHLTNCFNGGCPRCNDGDSRNLHTCLCLHAEENALLEAGRDRVGQNATLYCDTCPCLTCSVKIVQTGISEVVYSQSYRMDEESFKVLKNAGITVRQFSFTEEPRIVMI
SIO_010081: YHR144C
subclass of: SO_0000673
so part of: YHR144C
location: complement(387788..388726)
location: region:387788-388726:-1
so has part: feature:387788-388726:-1:exon

NP_012014.1
type: Protein
SIO_000068: ncbiprotein

S000001187
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387788-388726:-1:exon

YNCH0013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUF8
locus tag: YNCH0013C
so part of: sequence
location: complement(388893..388995)
location: region:388893-388995:-1
so has part: feature:388893-388995:-1:exon
subclass of: SO_0000663

856549
type: Gene
SIO_000068: ncbigene

position:388893:-1
position: 388893
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:388995:-1
position: 388995
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388893-388995:-1:exon

YNCH0013C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUF8
locus tag: YNCH0013C
product: tRNA-Pro
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE analysis; target of K. lactis zymocin; can mutate to suppress +1 frameshift mutations in proline codons
SIO_010081: YNCH0013C
subclass of: SO_0000673
so part of: YNCH0013C
location: complement(join(388893..388928,388960..388995))
location: region:388893-388995:-1
so has part: feature:388960-388995:-1:exon
so has part: feature:388893-388928:-1:exon

S000006682
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:388960-388995:-1:exon

position:388960:-1
position: 388960
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:388893-388928:-1:exon

position:388928:-1
position: 388928
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(389177..389509)
location: region:389177-389509:-1
so has part: feature:389177-389509:-1:region

S000006997
type: SGD
SIO_000068: sgd

position:389177:-1
position: 389177
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:389509:-1
position: 389509
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389177-389509:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(389613..389845)
location: region:389613-389845:-1
so has part: feature:389613-389845:-1:region

S000006998
type: SGD
SIO_000068: sgd

position:389613:-1
position: 389613
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:389845:-1
position: 389845
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:389613-389845:-1:region

YHR146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRP1
locus tag: YHR146W
so part of: sequence
location: <390300..>391697
location: region:390300-391697:1
so has part: feature:390300-391697:1:exon
subclass of: SO_0000010

856551
type: Gene
SIO_000068: ncbigene

position:390300:1
position: 390300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:391697:1
position: 391697
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390300-391697:1:exon

YHR146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRP1
locus tag: YHR146W
product: Crp1p
transcript id: NM_001179277.1
SIO_010081: YHR146W
subclass of: SO_0000673
so part of: YHR146W
location: <390300..>391697
location: region:390300-391697:1
so has part: feature:390300-391697:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390300-391697:1:exon

YHR146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRP1
locus tag: YHR146W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12419258]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12419258]
note: Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication
codon start: 1
product: Crp1p
translation: MSSELMFNYTFSWPAGPKDVILTGTFDDWRGTLPLVKTAKGNFEITMPVKLANKDDTFQFKFIVDGVWCVSDSYKKEHVSEGIENNFLQITDLVETQEVAGASRIPEAGGLLCGKPPRSAGPPSTSNRKKNKRNNKKRRSKLKKKSTKNNKKSNESLDDNEEEDGVTGTTTEDVTGTSREETPLAEPTNVSKEAPGNFHILPIDQSADTTQSNGIIGGPGPVLVPNPGEIKEFTEIRDVDARELNERLNKKEEVPEPVAGPIVESSVTEKSPALPQADDPIVETKEVAHNVQELTPQVEAVTPLINEPEPLPTPEAQISIPESSKVEPVEGSLQSKLVEKRESTEGVLDGSKKVENKAKKDEEVFTLDPIVNKAPKLPLTDEQTAEGRKSPAVSEEKEKKKKQEKGSKEVKRSETSKEKKPSAKEVKKQTVKAPKKQTASPLSSSTEEPKKKKTGFFGKLKKLFK
SIO_010081: YHR146W
subclass of: SO_0000673
so part of: YHR146W
location: 390300..391697
location: region:390300-391697:1
so has part: feature:390300-391697:1:exon

NP_012016.1
type: Protein
SIO_000068: ncbiprotein

S000001189
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390300-391697:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS818; Autonomously Replicating Sequence
so part of: sequence
location: 392180..392395
location: region:392180-392395:1
so has part: feature:392180-392395:1:region

S000118360
type: SGD
SIO_000068: sgd

position:392180:1
position: 392180
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:392395:1
position: 392395
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392180-392395:1:region

YHR147C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL6m
gene: MRPL6
locus tag: YHR147C
gene synonym: uL6m
so part of: sequence
location: complement(<392639..>393283)
location: region:392639-393283:-1
so has part: feature:392639-393283:-1:exon
subclass of: SO_0000010

856552
type: Gene
SIO_000068: ncbigene

position:392639:-1
position: 392639
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393283:-1
position: 393283
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392639-393283:-1:exon

YHR147C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL6m
gene: MRPL6
locus tag: YHR147C
gene synonym: uL6m
product: mitochondrial 54S ribosomal protein YmL16
transcript id: NM_001179278.1
SIO_010081: YHR147C
subclass of: SO_0000673
so part of: YHR147C
location: complement(<392639..>393283)
location: region:392639-393283:-1
so has part: feature:392639-393283:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392639-393283:-1:exon

YHR147C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL6m
gene: MRPL6
locus tag: YHR147C
gene synonym: uL6m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]
note: Mitochondrial ribosomal protein of the large subunit
codon start: 1
product: mitochondrial 54S ribosomal protein YmL16
translation: MSFIQRRLLSQTLFLRSQVGSLPLYISPEVQVSINALSMPRIIRKGRTSMNISQNITVKGPKGELSVEVPDFLHLDKDEKHGKINVTVQNSEDKHQRSMWGTVRSLINNHIIGVTEGHLAVLRFVGTGYRAQLENDGKFVNVKVGASIKQGLDVPEGIVVKTPAPTSLIIEGCNKQQVLLFAAKLRKFHPPEPYKGKGIYVNDETIKLKDKKIK
SIO_010081: YHR147C
subclass of: SO_0000673
so part of: YHR147C
location: complement(392639..393283)
location: region:392639-393283:-1
so has part: feature:392639-393283:-1:exon

NP_012017.1
type: Protein
SIO_000068: ncbiprotein

S000001190
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392639-393283:-1:exon

YHR148W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMP3
locus tag: YHR148W
so part of: sequence
location: <393534..>394085
location: region:393534-394085:1
so has part: feature:393534-394085:1:exon
subclass of: SO_0000010

856553
type: Gene
SIO_000068: ncbigene

position:393534:1
position: 393534
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394085:1
position: 394085
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:393534-394085:1:exon

YHR148W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMP3
locus tag: YHR148W
product: snoRNA-binding rRNA-processing protein IMP3
transcript id: NM_001179279.1
SIO_010081: YHR148W
subclass of: SO_0000673
so part of: YHR148W
location: <393534..>394085
location: region:393534-394085:1
so has part: feature:393534-394085:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:393534-394085:1:exon

YHR148W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMP3
locus tag: YHR148W
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:23980203]
experiment: EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:15489263|PMID:23980203]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:23980203]
experiment: EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:12242301]
note: Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
codon start: 1
product: snoRNA-binding rRNA-processing protein IMP3
translation: MVRKLKHHEQKLLKKVDFLEWKQDQGHRDTQVMRTYHIQNREDYHKYNRICGDIRRLANKLSLLPPTDPFRRKHEQLLLDKLYAMGVLTTKSKISDLENKVTVSAICRRRLPVIMHRLKMAETIQDAVKFIEQGHVRVGPNLINDPAYLVTRNMEDYVTWVDNSKIKKTLLRYRNQIDDFDFS
SIO_010081: YHR148W
subclass of: SO_0000673
so part of: YHR148W
location: 393534..394085
location: region:393534-394085:1
so has part: feature:393534-394085:1:exon

NP_012018.1
type: Protein
SIO_000068: ncbiprotein

S000001191
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:393534-394085:1:exon

YHR149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SKG6
locus tag: YHR149C
so part of: sequence
location: complement(<394455..>396659)
location: region:394455-396659:-1
so has part: feature:394455-396659:-1:exon
subclass of: SO_0000010

856554
type: Gene
SIO_000068: ncbigene

position:394455:-1
position: 394455
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:396659:-1
position: 396659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394455-396659:-1:exon

YHR149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SKG6
locus tag: YHR149C
product: Skg6p
transcript id: NM_001179280.1
SIO_010081: YHR149C
subclass of: SO_0000673
so part of: YHR149C
location: complement(<394455..>396659)
location: region:394455-396659:-1
so has part: feature:394455-396659:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394455-396659:-1:exon

YHR149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SKG6
locus tag: YHR149C
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:16314687]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:16314687|PMID:11489916]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11489916]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:16314687]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:16314687]
experiment: EXISTENCE:genetic interaction:GO:1902413 negative regulation of mitotic cytokinesis [PMID:16816427]
experiment: EXISTENCE:mutant phenotype:GO:1902413 negative regulation of mitotic cytokinesis [PMID:16816427]
note: Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog, TOS2, that arose from the whole genome duplication
codon start: 1
product: Skg6p
translation: MYHTHMHESLISVTSTVSVSDASYAYARLTRRDDSDSSSSSASSTKNSKSAECTGSKQQCQLPTDSSHSTSVTVGVAVAVPVGVIIIVLAVILCIVYRRSKKEAEEDNDPDFEGDSEFLPTMKDYSPGINHLYSSDSQQDFMEKTLQQPPSDPFVGSMHSSKYNVRSATPPAIGRSWYVDPFQLPQESNDSNSLRDFAMRVQEDGLGGYKVAAESRNASQTSLHPDNFSNCTPIRASSRFQESESFRSHGSPIHNNQLSRGSATEGANKQFTFPNEDNDSSSVSEEAEVLNESNESASNDAFEFELDNSSEKTHERNLRFGKDDDNYELQDIREAEHMNDRSSSKSQDDDYYVSLLSPNEEEDIKRMKSIYQVYLDRAKTMKKEEDKADNANDISQEENRVDNIVQNPLPSIKINNNDNIDNNEVPEAKHLVKEALPLNNTNLAEYGPEMAQSQKQYPVQDTLTVNDTEAAPSNRIASSIYSEAIQPLNYQDQYQQQEQSPVYNGHTQYPGNGYSGNPQQQGYTAQFVQNPQWYGVPTPQQQQHNHPQTLETIGELPTPAYLAQSASSHSLTSFKRPNKQQLLQLQTARLNGTALNPVDHPEMFYSPTNDAYYAPQQQGQYMKFNENGAVPSPYQLRQSVVMTNPSDLTAKPSYKPAGSFRSVSATNSRNNSLTTQNNIYLQQQQQQLYNSRVSGILEETDVVQPPSVGGILPHSGSQDDLRKQLGSSHNYTVN
SIO_010081: YHR149C
subclass of: SO_0000673
so part of: YHR149C
location: complement(394455..396659)
location: region:394455-396659:-1
so has part: feature:394455-396659:-1:exon

NP_012019.1
type: Protein
SIO_000068: ncbiprotein

S000001192
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394455-396659:-1:exon

YHR150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEX28
locus tag: YHR150W
so part of: sequence
location: <397251..>398990
location: region:397251-398990:1
so has part: feature:397251-398990:1:exon
subclass of: SO_0000010

856555
type: Gene
SIO_000068: ncbigene

position:397251:1
position: 397251
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:398990:1
position: 398990
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397251-398990:1:exon

YHR150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEX28
locus tag: YHR150W
product: Pex28p
transcript id: NM_001179281.1
SIO_010081: YHR150W
subclass of: SO_0000673
so part of: YHR150W
location: <397251..>398990
location: region:397251-398990:1
so has part: feature:397251-398990:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397251-398990:1:exon

YHR150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEX28
locus tag: YHR150W
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:12707309]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0007031 peroxisome organization [PMID:12707309]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12707309]
note: Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
codon start: 1
product: Pex28p
translation: MSETSSSRRSASKDAVKSYFAGKYNKVLDSILEAEAAISKSPTVAEDLSGSSSSGNSEMSHPSLTASSATSQGISKKELLQQIAGSLFSTSIERLKTAHSSEVSSTPEYSVNDSYGEQECRECDGVFKCSAHFEGAPEYYDDETESGPALEPMTSNSEKDPFIDVFLDKLISRLVPEKLPEREHFSSKTTIEHDLDTGRVPVFSATTLGSNFKKLSKKMGSIFELQDSIVRLLTWRNPTGTVTSLILFTLICFNPMYLVILPIFRFVYGIVVPGYVRKHPLQRSIYPLKRNHGSSLLYDVCYEGKNEYSYGQQFFSKSFMDTLESRNQEIDEISELDKRTENTGELKQGMKVLINLRDMQNMTSGTLHVIEAINSFLRKSSSFQNEECSTKRFFTGFLLIVFLKILSPFVNWSYVCSIFAWCLLIYMHPRAHPKIISFFKTGTMGKEYKNLKKREHQALNMIFDEQPETKFIEIFEIYKKALLPNDWKFFRYSNRIFDPQDPYRRAQQFPPGVDSLADVIPPTGWSFDPNFEWKIDNDVDRWVVERGLNLPITGEFLFDPMFKRRRLIHRVIKNATPVA
SIO_010081: YHR150W
subclass of: SO_0000673
so part of: YHR150W
location: 397251..398990
location: region:397251-398990:1
so has part: feature:397251-398990:1:exon

NP_012020.1
type: Protein
SIO_000068: ncbiprotein

S000001193
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397251-398990:1:exon

YHR151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTC6
locus tag: YHR151C
so part of: sequence
location: complement(<399268..>400848)
location: region:399268-400848:-1
so has part: feature:399268-400848:-1:exon
subclass of: SO_0000010

856556
type: Gene
SIO_000068: ncbigene

position:399268:-1
position: 399268
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400848:-1
position: 400848
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:399268-400848:-1:exon

YHR151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTC6
locus tag: YHR151C
product: Mtc6p
transcript id: NM_001179282.1
SIO_010081: YHR151C
subclass of: SO_0000673
so part of: YHR151C
location: complement(<399268..>400848)
location: region:399268-400848:-1
so has part: feature:399268-400848:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:399268-400848:-1:exon

YHR151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTC6
locus tag: YHR151C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; mtc6 is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum
codon start: 1
product: Mtc6p
translation: MWILIYLFIIWSSLRTWVTAVDSTTTVGDDLNETVSASVWPTMSPQMTVAFRSQRDVMGNLTIDQLPYVGLNLRRVLLNNETSMVNEGNNTRLLTLFKSMLSSEANAFVLDLEQYNNDLRVVDTTLLFSDVLTALQSFIFSTQNNLYANIIVLLLNISAPELDSTEYRHQNQTLNTTYILDKNLGNSFIYKPTDLQSDRAKNNTWNIYGKSSIDGWPTLGSVLYEQKKRLVIGELTDFFNETTAPYIFPHDVFHYEQGNSTLDCPSTVEGLTDLSSIHWRFLDSLFNSVDIKEYISCGLSPIISNSAYVNNVTQLADIIHEGSVWSWDSDQPSVTQSTSKSGSSSGTLEAYNCVLLYYFANNETVTWRVGNCYNSNIGLCRYENMAFRWLVRSNKATYFDFDSYQGSKCPDQYSFNIPRSPLEQRSFIAYMRNSSFSDTQIWIDLNSISVSNCWVSGGPYASCPYEKVISRRNFVTMMVPASVCSFALLCIVVYLSVLRVPIYDNRKNWRRVINKISKSELEGVPS
SIO_010081: YHR151C
subclass of: SO_0000673
so part of: YHR151C
location: complement(399268..400848)
location: region:399268-400848:-1
so has part: feature:399268-400848:-1:exon

NP_012021.1
type: Protein
SIO_000068: ncbiprotein

S000001194
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:399268-400848:-1:exon

YHR152W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SDB21
gene: SPO12
locus tag: YHR152W
gene synonym: SDB21
so part of: sequence
location: <401434..>401955
location: region:401434-401955:1
so has part: feature:401434-401955:1:exon
subclass of: SO_0000010

856557
type: Gene
SIO_000068: ncbigene

position:401434:1
position: 401434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:401955:1
position: 401955
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401434-401955:1:exon

YHR152W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SDB21
gene: SPO12
locus tag: YHR152W
gene synonym: SDB21
product: Spo12p
transcript id: NM_001179283.1
SIO_010081: YHR152W
subclass of: SO_0000673
so part of: YHR152W
location: <401434..>401955
location: region:401434-401955:1
so has part: feature:401434-401955:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:401434-401955:1:exon

YHR152W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SDB21
gene: SPO12
locus tag: YHR152W
gene synonym: SDB21
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11729145|PMID:10564265]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11729145]
experiment: EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:11832211]
experiment: EXISTENCE:genetic interaction:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]
experiment: EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:7021311]
experiment: EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:27418100|PMID:11832211]
experiment: EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]
note: Nucleolar hypothetical protein; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication
codon start: 1
product: Spo12p
translation: MSNKASDQSARTASILKTDITRENTITRSSSSNNDNYHHHNNINNYNESAKTGEDANKENIPNLEEEIAAFRIFRKKSTSNLKSSHTTSNLVKKTMFKRDLLKQDPKRKLQLQQRFASPTDRLVSPCSLKLNEHKVKMFGKKKKVNPMKLNFKGNLAADSEDVEIDEDEEYFY
SIO_010081: YHR152W
subclass of: SO_0000673
so part of: YHR152W
location: 401434..401955
location: region:401434-401955:1
so has part: feature:401434-401955:1:exon

NP_012022.1
type: Protein
SIO_000068: ncbiprotein

S000001195
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401434-401955:1:exon

YHR153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO16
locus tag: YHR153C
so part of: sequence
location: complement(<402086..>402682)
location: region:402086-402682:-1
so has part: feature:402086-402682:-1:exon
subclass of: SO_0000010

856558
type: Gene
SIO_000068: ncbigene

position:402086:-1
position: 402086
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402682:-1
position: 402682
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402086-402682:-1:exon

YHR153C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO16
locus tag: YHR153C
product: Spo16p
transcript id: NM_001179284.1
SIO_010081: YHR153C
subclass of: SO_0000673
so part of: YHR153C
location: complement(<402086..>402682)
location: region:402086-402682:-1
so has part: feature:402086-402682:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402086-402682:-1:exon

YHR153C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO16
locus tag: YHR153C
experiment: EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:30566683]
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:18297071]
experiment: EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:18297071]
experiment: EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18297071]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2188099]
experiment: EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23326245]
note: Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
codon start: 1
product: Spo16p
translation: MSEFFWDVQKIQEISNVEEHSVVKCVTVNTSRLISQLNEELQDEESGVNFIVTQLQLLINNVYEKIQKSPGVPAHRSLMINLNFTRLKFSIAYWDILLERSLDLINGPSKTGARYFITEVTPVDRSRYVENNQYFLAFKANQRLTRNSVDMDEFIDFEILIKQIIFDLFKKNGIPDQDFEAILSRFHNLESLVVAFNE
SIO_010081: YHR153C
subclass of: SO_0000673
so part of: YHR153C
location: complement(402086..402682)
location: region:402086-402682:-1
so has part: feature:402086-402682:-1:exon

NP_012023.1
type: Protein
SIO_000068: ncbiprotein

S000001196
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402086-402682:-1:exon

YHR154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ESC4
gene: RTT107
locus tag: YHR154W
gene synonym: ESC4
so part of: sequence
location: <402966..>406178
location: region:402966-406178:1
so has part: feature:402966-406178:1:exon
subclass of: SO_0000010

856559
type: Gene
SIO_000068: ncbigene

position:402966:1
position: 402966
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:406178:1
position: 406178
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402966-406178:1:exon

YHR154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ESC4
gene: RTT107
locus tag: YHR154W
gene synonym: ESC4
product: Rtt107p
transcript id: NM_001179285.1
SIO_010081: YHR154W
subclass of: SO_0000673
so part of: YHR154W
location: <402966..>406178
location: region:402966-406178:1
so has part: feature:402966-406178:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402966-406178:1:exon

YHR154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ESC4
gene: RTT107
locus tag: YHR154W
gene synonym: ESC4
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:17978089]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:14988729]
experiment: EXISTENCE:mutant phenotype:GO:0010526 negative regulation of transposition, RNA-mediated [PMID:11779788]
experiment: EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:26490958]
experiment: EXISTENCE:mutant phenotype:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]
experiment: EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:26490958]
note: BRCA1 C-terminal domain protein needed for recovery from DNA damage; implicated in Mms22-dependent DNA repair during S phase; involved in recruiting SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress
codon start: 1
product: Rtt107p
translation: MSTSLLFEQLNFLILVAAEAELPIAHSTRKLLMDNSCNNCQIYELYNENLKDVKTDKDWFMNKFGPQTVHFVISNTINFPFYKIVYFDLLIPVVSHTWVQDSVKTKRHLRTNMYSPNPFHLLRDCQVYISKSSFNKCEYILYSDLLHLLGGTLVNYISNRTTHVIVQSPQDPIIATVSKLTFGSFSSSSTNKHTEKPLREWKFVYPIWILYHFKMAKPLKGELATLCELDMQDTSEEQLFAKWEEVIGDKQTSSSQLTLHPNKTLFKNHHFAISPDLNFFTPLYWFLKGFIEDLDGKVTPLSFSDDLKSVYQAFPDIDCYIGHSANSPILEKTKSIKPEIHVGNVSWLFYMFALQKFTPVSQCKLIHQPFHAKLFTSKELTVAYTNYFGSQRFYIQRLVEILGGLSTPELTRKNTHLITKSTIGKKFKVAKKWSLDPQNAIIVTNHMWLEQCYMNNSKLNPKDSRFQNFKLDDNMGWNIGQIGMDHSSLPTPKNLSMVTYDTQSISEKPPPTNDQMDQINDNTNVLSKKDGTPISSFENSIDEKIDKLQKISGEVAVTHSGDLERSFVSRPSRASFPVVDSKKSNLQKKDSNSDISMETEVFCEGHEKREEKEFTKPITEYDAPKKQEIREQSRKKNDIDYKKEEEETELQVQLGQRTKREIKTSKKNEKEKETNECHIEVDQMTNEKQGEESTGKLISTEDVTSKKDTDKFSHLFEGLSDNDDHINDEKPAVNSKYTTPKTSQNITSGVDTPTTAQTQVFMPSSGNSRLAKTQAAKRLHTDIESLNEFQKNFKRKRIDSEEISLSQDVERSNNNKELATKAEKILARFNELPNYDLKAVCTGCFHDGFNEVDIEILNQLGIKIFDNIKETDKLNCIFAPKILRTEKFLKSLSFEPLKFALKPEFIIDLLKQIHSKKDKLSQININLFDYEINGINESIISKTKLPTKVFERANIRCINLVNDIPGGVDTIGSVLKAHGIEKINVLRSKKCTFEDIIPNDVSKQENGGIFKYVLIVTKASQVKKFTKLINDRDKNETILIVEWNWCVESIFHLNVDFTSKKNVLYQKKNN
SIO_010081: YHR154W
subclass of: SO_0000673
so part of: YHR154W
location: 402966..406178
location: region:402966-406178:1
so has part: feature:402966-406178:1:exon

NP_012024.1
type: Protein
SIO_000068: ncbiprotein

S000001197
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402966-406178:1:exon

YHR155W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YSP1
gene: LAM1
locus tag: YHR155W
gene synonym: YSP1
so part of: sequence
location: <407103..>410789
location: region:407103-410789:1
so has part: feature:407103-410789:1:exon
subclass of: SO_0000010

856560
type: Gene
SIO_000068: ncbigene

position:407103:1
position: 407103
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:410789:1
position: 410789
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407103-410789:1:exon

YHR155W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YSP1
gene: LAM1
locus tag: YHR155W
gene synonym: YSP1
product: Lam1p
transcript id: NM_001179286.1
SIO_010081: YHR155W
subclass of: SO_0000673
so part of: YHR155W
location: <407103..>410789
location: region:407103-410789:1
so has part: feature:407103-410789:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407103-410789:1:exon

YHR155W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YSP1
gene: LAM1
locus tag: YHR155W
gene synonym: YSP1
experiment: EXISTENCE:curator inference:GO:0015248 sterol transporter activity [PMID:26001273]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15657396|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]
experiment: EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]
note: Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains
codon start: 1
product: Lam1p
translation: MHEHKAELRLITVALNEASTDSPSFRASVNYFHTRMESLSSWMHSTVDYVENTYKPSFQDFQRIKETLFSQLLPSPILLSNGFVSNQPYTPLLVRDFTRDVSDLSNTVMKIILGDENSQYTAALSALSSDAINPYFNKRKTFEYYQRKYDSFLTDFLAATNDGNTLIPQNLQNETFKLVDIKHKYIEASLDLTEAISLMKVNLDKFLIETIDIVRKNNVITTKDTKDVIDITPELTETLKDWTDWIESNLQTLQALSSKLSEAKYAILKLSLARMKPSRLIQDYDLKSIQNLKFNLPKSISNGNNSEEKGLSGWLYMKTTVGHDPKRVVWVRRWCFLQNNVFGVFSLSPSKTYVEETDKFGILWITVEYLPKEPRNFCFKLRIQNPNCKTEEENTYIDIILQAESIDELKSWINTLTSHKRIALSIKEENDPRYQLARKKIEPQFFEFASSSSTSTDKLLTSFSSKTLTLVEELKKNYMSEDDIYSIIDNKAYHLRVISTPIATQLTHLALFSTFLSVSNYYPCATQANTWGTANWNDLSYLVNPLKGSSVHKPATVSNSSRFSVSYPDYYPYSLKVDDIQFRSIFFSVNHDFLQVPKELVLLRYSSVWCPNNKQKFASMAFVTLNHIYVYLNISGFSYLRRIDLLDIDSIEYDKSPKHVSSRMLHMQRGDGLRFNMSVFFTDRRAVASKLQFLIENKAMHIPKGEKEVLEIFQELDEEIENEKKIIKDNLSESEHYSKDYDYLLKSTYDHHFENTNETPMELMSRKLRLEREAWCYFQDNFKVGSKTLFHVLFGDKSQVFPSSLFLCKKGSNLNNNSYWERIRRAKEDASCQFELCRKLQFQLNRTSNFIKDLLWLKDDNDNFKLVLQQRVTKIKQGYYFEVEEGPIIVKFPLCHPLLLRVRFIIAECITSQGESLKKCDLAILYDFNYVESIDKLNTKVEKLWLFERIHLNWALRYCKLEHSEINRKTREYLKKFNDREKMSDVIKLCGFLGVLPKERIENDEKAGDFMQPVYINYDFLSLSKIFTKLTVFYLSSVIIKTMKVLLAMVMVIFKCFSKVNKTLYYCLLISAVTNLFFVGKSIHSYFSVKSAETLFQNYANGDQRGLQIMHRSLTVPDLNLLTRKMMDNDQENPVFKRFDEDKNAYQYKGTRQEIAIKRNQVLTELKILQNTEKELVQGSYRKFIITERDKCITTQNEIFDLWINDTKLQDYCMACFAEYNRLSAIPV
SIO_010081: YHR155W
subclass of: SO_0000673
so part of: YHR155W
location: 407103..410789
location: region:407103-410789:1
so has part: feature:407103-410789:1:exon

NP_012025.1
type: Protein
SIO_000068: ncbiprotein

S000001198
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407103-410789:1:exon

YNCH0014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR71
locus tag: YNCH0014W
so part of: sequence
location: 411228..411317
location: region:411228-411317:1
so has part: feature:411228-411317:1:exon
subclass of: SO_0000578

9164902
type: Gene
SIO_000068: ncbigene

position:411228:1
position: 411228
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:411317:1
position: 411317
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411228-411317:1:exon

YNCH0014W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR71
locus tag: YNCH0014W
product: SNR71
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A2946
transcript id: NR_132189.1
SIO_010081: YNCH0014W
subclass of: SO_0000673
so part of: YNCH0014W
location: 411228..411317
location: region:411228-411317:1
so has part: feature:411228-411317:1:exon

S000006462
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411228-411317:1:exon

YHR156C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SNU40
gene: LIN1
locus tag: YHR156C
gene synonym: SNU40
so part of: sequence
location: complement(<411384..>412406)
location: region:411384-412406:-1
so has part: feature:411384-412406:-1:exon
subclass of: SO_0000010

856561
type: Gene
SIO_000068: ncbigene

position:411384:-1
position: 411384
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412406:-1
position: 412406
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411384-412406:-1:exon

YHR156C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SNU40
gene: LIN1
locus tag: YHR156C
gene synonym: SNU40
product: U5 snRNP complex subunit LIN1
transcript id: NM_001179287.1
SIO_010081: YHR156C
subclass of: SO_0000673
so part of: YHR156C
location: complement(<411384..>412406)
location: region:411384-412406:-1
so has part: feature:411384-412406:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:411384-412406:-1:exon

YHR156C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SNU40
gene: LIN1
locus tag: YHR156C
gene synonym: SNU40
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12402242]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12402242]
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:11720284]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12402242]
note: Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
codon start: 1
product: U5 snRNP complex subunit LIN1
translation: MKYTQYPNSSKLKRNSDRREHDEKLSDELHNQSTIYEDEELSRAEYDSDSDSSVEDSTDNENSGKEMDEKSYEKNEDHVEDHRKRKKSKIQLLDIAEFKKENLADLDYQIGNSESKVEKGVNIEPFNIDDEIKHGVFDKDGNYIKTENATENDQQDNEEWMNDVINTEEVNRLEKEQSVKTQNSRHYMVHEALNLLKFFLVDENETVLESLGRLNKLRKIAISKKNKSLKYVIHGIELLSDLINILEKKGFSEVYEYNRLKVQDAIEEEIFDDSSRIVNHKTKLWGFKWLNKLDEYHGLYTNYEMSYWQKSYFKNSVIVKFHSEPDRDENWIHVSCLSFM
SIO_010081: YHR156C
subclass of: SO_0000673
so part of: YHR156C
location: complement(411384..412406)
location: region:411384-412406:-1
so has part: feature:411384-412406:-1:exon

NP_012026.1
type: Protein
SIO_000068: ncbiprotein

S000001199
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411384-412406:-1:exon

YHR157W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: REC104
locus tag: YHR157W
so part of: sequence
location: <412907..>413455
location: region:412907-413455:1
so has part: feature:412907-413455:1:exon
subclass of: SO_0000010

856562
type: Gene
SIO_000068: ncbigene

position:412907:1
position: 412907
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:413455:1
position: 413455
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412907-413455:1:exon

YHR157W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: REC104
locus tag: YHR157W
product: Rec104p
transcript id: NM_001179288.1
SIO_010081: YHR157W
subclass of: SO_0000673
so part of: YHR157W
location: <412907..>413455
location: region:412907-413455:1
so has part: feature:412907-413455:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:412907-413455:1:exon

YHR157W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: REC104
locus tag: YHR157W
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15044957]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:9177999]
note: Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
codon start: 1
product: Rec104p
translation: MSIEEEDTNKITCTQDFLHQYFVTERVSIQFGLNNKTVKRINKDEFDKAVNCIMSWTNYPKPGLKRTASTYLLSNSFKKSATVSLPFILGDPVCMPKRVESNNNDTCLLYSDTLYDDPLIQRNDQAGDEIEDEFSFTLLRSEVNEIRPISSSSTAQILQSDYSALMYERQASNGSIFQFSSP
SIO_010081: YHR157W
subclass of: SO_0000673
so part of: YHR157W
location: 412907..413455
location: region:412907-413455:1
so has part: feature:412907-413455:1:exon

NP_012027.1
type: Protein
SIO_000068: ncbiprotein

S000001200
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:412907-413455:1:exon

YHR158C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KEL1
locus tag: YHR158C
so part of: sequence
location: complement(<413685..>417179)
location: region:413685-417179:-1
so has part: feature:413685-417179:-1:exon
subclass of: SO_0000010

856563
type: Gene
SIO_000068: ncbigene

position:413685:-1
position: 413685
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:417179:-1
position: 417179
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413685-417179:-1:exon

YHR158C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KEL1
locus tag: YHR158C
product: Kel1p
transcript id: NM_001179289.1
SIO_010081: YHR158C
subclass of: SO_0000673
so part of: YHR158C
location: complement(<413685..>417179)
location: region:413685-417179:-1
so has part: feature:413685-417179:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413685-417179:-1:exon

YHR158C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KEL1
locus tag: YHR158C
experiment: EXISTENCE:direct assay:GO:0005515 protein binding [PMID:34965431]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9786949]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9786949]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23673619]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9786949|PMID:19053807]
experiment: EXISTENCE:direct assay:GO:1990615 Kelch-containing formin regulatory complex [PMID:24828508]
experiment: EXISTENCE:genetic interaction:GO:0032465 regulation of cytokinesis [PMID:24828508]
experiment: EXISTENCE:genetic interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:24828508]
experiment: EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9786949]
experiment: EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:12234925]
experiment: EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:34965431]
experiment: EXISTENCE:mutant phenotype:GO:0008360 regulation of cell shape [PMID:9786949]
experiment: EXISTENCE:mutant phenotype:GO:0060627 regulation of vesicle-mediated transport [PMID:24828508]
experiment: EXISTENCE:mutant phenotype:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:34965431]
note: Protein required for proper cell fusion and cell morphology; acts as phosphorylation-regulated noise suppressor of pheromone signaling pathway; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
codon start: 1
product: Kel1p
translation: MAGFSFAKKFTHKKHGKTPSDASISDQSREASLSTPPNEKFFTKQETPQKGRQFSQGYHSNVNKTSSPPMFARKQVSESRIQPSAVPPQQRNVSGPSTTLHKQLSKQREYTVWNRIKLQNSPFPRYRHVASAYVTDKNQIYVIGGLHDQSVYGDTWILTAFDNATRFSTTTIDISEATPPPRVGHAAVLCGNAFVVFGGDTHKVNKEGLMDDDIYLLNINSYKWTVPAPVGPRPLGRYGHKISIIATTQMKTKLYVFGGQFDDTYFNDLAVYDLSSFRRPDSHWEFLKPRTFTPPPITNFTMISYDSKLWVFGGDTLQGLVNDVFMYDPAINDWFIIDTTGEKPPPVQEHATVVYNDLMCVVGGKDEHDAYLNSVYFLNLKSRKWFKLPVFTAGIPQGRSGHSLTLLKNDKILIMGGDKFDYARVEEYDLHTSDIDMQRGTIVYTLDLARIKDLCPGVMDVPTDTPTPRNGNLDLATPVTPTSHQTKNMNVPISAAPLASAPSPAPKDFSDADRLNREVHNRNVSTEHQNQSHPVNSESHLIAEPNILTPYVPSESSQTPVMKITSNKPFDTPTIQKEPDLSETMDPTVGNQRIPSSIYGDNLTPANQIKNNSPILETLPSNEIKTPQNGNIEEIKHLPDADEKIDSTTTFDQEINGDKLGTSSMSKVEEDGNVADEDDEIGVAQMASSPSKDQFKIKHYNESSELSQNNTEIDKLSEPVDITIKKSDTAGHDSANHVIDASDEKNVSPMGDVPTDTKNEEASVPINRDATTEVVDRALFEKLRSELQSLKELTHEKALEAGAHIKELETELWQLKSQKNSGTTKEIDELDSVRLQSKCEILEADNHSLEDKVNELEELVNSKFLDIENLNEVIQFQNEKIKSLELEPNYKEKLEELQIEHENLSRENERLKNESKQHNEDIINNVANYSSQLGSLISHWKENRANSSFLESSSSLISVSDENGEKTVGEPYGDQSRHHRVVINKLTNRLDDLLERSQELTISKEKLSSEYHALKMEHSSLSQDVLVKENEIKKIQNDYKESISSMDSASKALMVSQRELEKYKSLNKKLIDELDELKFKNGVCSENFENGLRSTEESSNNVKNSNSIRENQFNIKINDLKAELFITNQERDDLKSEVLELKKRLLNLENNTKQVNEDADSDLL
SIO_010081: YHR158C
subclass of: SO_0000673
so part of: YHR158C
location: complement(413685..417179)
location: region:413685-417179:-1
so has part: feature:413685-417179:-1:exon

NP_012028.1
type: Protein
SIO_000068: ncbiprotein

S000001201
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413685-417179:-1:exon

YHR159W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TDA11
locus tag: YHR159W
so part of: sequence
location: <417549..>419063
location: region:417549-419063:1
so has part: feature:417549-419063:1:exon
subclass of: SO_0000010

856564
type: Gene
SIO_000068: ncbigene

position:417549:1
position: 417549
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:419063:1
position: 419063
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417549-419063:1:exon

YHR159W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TDA11
locus tag: YHR159W
product: Tda11p
transcript id: NM_001179290.1
SIO_010081: YHR159W
subclass of: SO_0000673
so part of: YHR159W
location: <417549..>419063
location: region:417549-419063:1
so has part: feature:417549-419063:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417549-419063:1:exon

YHR159W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TDA11
locus tag: YHR159W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
codon start: 1
product: Tda11p
translation: MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNMRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVKNSVEMTDF
SIO_010081: YHR159W
subclass of: SO_0000673
so part of: YHR159W
location: 417549..419063
location: region:417549-419063:1
so has part: feature:417549-419063:1:exon

NP_012029.1
type: Protein
SIO_000068: ncbiprotein

S000001202
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417549-419063:1:exon

YHR160C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEX18
locus tag: YHR160C
so part of: sequence
location: complement(<419221..>420072)
location: region:419221-420072:-1
so has part: feature:419221-420072:-1:exon
subclass of: SO_0000010

856565
type: Gene
SIO_000068: ncbigene

position:419221:-1
position: 419221
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420072:-1
position: 420072
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:419221-420072:-1:exon

YHR160C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEX18
locus tag: YHR160C
product: Pex18p
transcript id: NM_001179291.1
SIO_010081: YHR160C
subclass of: SO_0000673
so part of: YHR160C
location: complement(<419221..>420072)
location: region:419221-420072:-1
so has part: feature:419221-420072:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:419221-420072:-1:exon

YHR160C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEX18
locus tag: YHR160C
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9864360]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9864360]
experiment: EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:9864360]
experiment: EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:9864360]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9864360]
note: Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth
codon start: 1
product: Pex18p
translation: MNSNRCQTNEVNKFISSTEKGPFTGRDNTLSFNKIGSRLNSPPILKDKIELKFLQHSEDLNQSRSYVNIRPRTLEDQSYKFEAPNLNDNETSWAKDFRYNFPKNVEPPIENQIANLNINNGLRTSQTDFPLGFYSQKNFNIASFPVVDHQIFKTTGLEHPINSHIDSLINAEFSELEASSLEEDVHTEEENSGTSLEDEETAMKGLASDIIEFCDNNSANKDVKERLNSSKFMGLMGSISDGSIVLKKDNGTERNLQKHVGFCFQNSGNWAGLEFHDVEDRIA
SIO_010081: YHR160C
subclass of: SO_0000673
so part of: YHR160C
location: complement(419221..420072)
location: region:419221-420072:-1
so has part: feature:419221-420072:-1:exon

NP_012030.1
type: Protein
SIO_000068: ncbiprotein

S000001203
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:419221-420072:-1:exon

YHR161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YAP1801
locus tag: YHR161C
so part of: sequence
location: complement(<420373..>422286)
location: region:420373-422286:-1
so has part: feature:420373-422286:-1:exon
subclass of: SO_0000010

856566
type: Gene
SIO_000068: ncbigene

position:420373:-1
position: 420373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:422286:-1
position: 422286
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:420373-422286:-1:exon

YHR161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YAP1801
locus tag: YHR161C
product: Yap1801p
transcript id: NM_001179292.1
SIO_010081: YHR161C
subclass of: SO_0000673
so part of: YHR161C
location: complement(<420373..>422286)
location: region:420373-422286:-1
so has part: feature:420373-422286:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:420373-422286:-1:exon

YHR161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YAP1801
locus tag: YHR161C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33443082]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:9531549]
experiment: EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:9531549]
note: Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication
codon start: 1
product: Yap1801p
translation: MTTYFKLVKGATKIKSAPPKQKYLDPILLGTSNEEDFYEIVKGLDSRINDTAWTIVYKSLLVVHLMIREGSKDVALRYYSRNLEFFDIENIRGSNGSASGDMRALDRYDNYLKVRCREFGKIKKDYVRDGYRTLKLNSGNYGSSRNKQHSINIALDHVESLEVQIQALIKNKYTQYDLSNELIIFGFKLLIQDLLALYNALNEGIITLLESFFELSHHNAERTLDLYKTFVDLTEHVVRYLKSGKTAGLKIPVIKHITTKLVRSLEEHLIEDDKTHNTFVPVDSSQGSAGAVVAKSTAQERLEQIREQKRILEAQLKNEQVAISPALTTVTAAQSYNPFGTDSSMHTNIPMAVANQTQQIANNPFVSQTQPQVMNTPTAHTEPANLNVPEYAAVQHTVNFNPVQDAGVSAQQTGYYSINNHLTPTFTGAGFGGYSVSQDTTAASNQQVSHSQTGSNNPFALHNAATIATGNPAHENVLNNPFSRPNFDEQNTNMPLQQQIISNPFQNQTYNQQQFQQQKMPLSSINSVMTTPTSMQGSMNIPQRFDKMEFQAHYTQNHLQQQQQQQQQQQQQQQQQPQQGYYVPATAGANPVTNITGTVQPQNFPFYPQQQPQPEQSQTQQPVLGNQYANNLNLIDM
SIO_010081: YHR161C
subclass of: SO_0000673
so part of: YHR161C
location: complement(420373..422286)
location: region:420373-422286:-1
so has part: feature:420373-422286:-1:exon

NP_012031.1
type: Protein
SIO_000068: ncbiprotein

S000001204
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:420373-422286:-1:exon

YHR162W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPC2
locus tag: YHR162W
so part of: sequence
location: <423072..>423461
location: region:423072-423461:1
so has part: feature:423072-423461:1:exon
subclass of: SO_0000010

856567
type: Gene
SIO_000068: ncbigene

position:423072:1
position: 423072
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:423461:1
position: 423461
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423072-423461:1:exon

YHR162W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPC2
locus tag: YHR162W
product: mitochondrial pyruvate carrier
transcript id: NM_001179293.1
SIO_010081: YHR162W
subclass of: SO_0000673
so part of: YHR162W
location: <423072..>423461
location: region:423072-423461:1
so has part: feature:423072-423461:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:423072-423461:1:exon

YHR162W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPC2
locus tag: YHR162W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22628558]
experiment: EXISTENCE:direct assay:GO:0006850 mitochondrial pyruvate transmembrane transport [PMID:25672363]
experiment: EXISTENCE:direct assay:GO:0050833 pyruvate transmembrane transporter activity [PMID:25672363]
experiment: EXISTENCE:genetic interaction:GO:0006850 mitochondrial pyruvate transmembrane transport [PMID:22628554]
experiment: EXISTENCE:mutant phenotype:GO:0006850 mitochondrial pyruvate transmembrane transport [PMID:22628558]
experiment: EXISTENCE:physical interaction:GO:0050833 pyruvate transmembrane transporter activity [PMID:22628558]
note: Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform
codon start: 1
product: mitochondrial pyruvate carrier
translation: MSTSSVRFAFRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYRIRNGDSISQLCSYILSGADESKKEITTGR
SIO_010081: YHR162W
subclass of: SO_0000673
so part of: YHR162W
location: 423072..423461
location: region:423072-423461:1
so has part: feature:423072-423461:1:exon

NP_012032.1
type: Protein
SIO_000068: ncbiprotein

S000001205
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423072-423461:1:exon

YHR163W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOL3
locus tag: YHR163W
so part of: sequence
location: <423724..>424473
location: region:423724-424473:1
so has part: feature:423724-424473:1:exon
subclass of: SO_0000010

856568
type: Gene
SIO_000068: ncbigene

position:423724:1
position: 423724
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:424473:1
position: 424473
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423724-424473:1:exon

YHR163W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOL3
locus tag: YHR163W
product: 6-phosphogluconolactonase SOL3
transcript id: NM_001179294.1
SIO_010081: YHR163W
subclass of: SO_0000673
so part of: YHR163W
location: <423724..>424473
location: region:423724-424473:1
so has part: feature:423724-424473:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:423724-424473:1:exon

YHR163W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOL3
locus tag: YHR163W
EC number: 3.1.1.31
experiment: EXISTENCE:curator inference:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:15454531]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0017057 6-phosphogluconolactonase activity [PMID:15454531]
note: 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
codon start: 1
product: 6-phosphogluconolactonase SOL3
translation: MVTVGVFSERASLTHQLGEFIVKKQDEALQKKSDFKVSVSGGSLIDALYESLVADESLSSRVQWSKWQIYFSDERIVPLTDADSNYGAFKRAVLDKLPSTSQPNVYPMDESLIGSDAESNNKIAAEYERIVPQVLDLVLLGCGPDGHTCSLFPGETHRYLLNETTKRVAWCHDSPKPPSDRITFTLPVLKDAKALCFVAEGSSKQNIMHEIFDLKNDQLPTALVNKLFGEKTSWFVNEEAFGKVQTKTF
SIO_010081: YHR163W
subclass of: SO_0000673
so part of: YHR163W
location: 423724..424473
location: region:423724-424473:1
so has part: feature:423724-424473:1:exon

NP_012033.2
type: Protein
SIO_000068: ncbiprotein

S000001206
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423724-424473:1:exon

YHR164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: WEB2
gene: DNA2
locus tag: YHR164C
gene synonym: WEB2
so part of: sequence
location: complement(<424610..>429178)
location: region:424610-429178:-1
so has part: feature:424610-429178:-1:exon
subclass of: SO_0000010

856569
type: Gene
SIO_000068: ncbigene

position:424610:-1
position: 424610
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:429178:-1
position: 429178
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424610-429178:-1:exon

YHR164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: WEB2
gene: DNA2
locus tag: YHR164C
gene synonym: WEB2
product: bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2
transcript id: NM_001179295.1
SIO_010081: YHR164C
subclass of: SO_0000673
so part of: YHR164C
location: complement(<424610..>429178)
location: region:424610-429178:-1
so has part: feature:424610-429178:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:424610-429178:-1:exon

YHR164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: WEB2
gene: DNA2
locus tag: YHR164C
gene synonym: WEB2
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:9756935|PMID:23671118]
experiment: EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:32638513]
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:12024033]
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:7644470]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19520826|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]
experiment: EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:9710536]
experiment: EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:15448135]
experiment: EXISTENCE:direct assay:GO:0032448 DNA hairpin binding [PMID:23344960]
experiment: EXISTENCE:direct assay:GO:0043539 protein serine/threonine kinase activator activity [PMID:23355394]
experiment: EXISTENCE:direct assay:GO:0044806 G-quadruplex DNA unwinding [PMID:18593712]
experiment: EXISTENCE:direct assay:GO:0061849 telomeric G-quadruplex DNA binding [PMID:18593712]
experiment: EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]
experiment: EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:21841787]
experiment: EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:23355394]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:12024033]
experiment: EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:18805091]
experiment: EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:7592912]
experiment: EXISTENCE:mutant phenotype:GO:0006273 lagging strand elongation [PMID:10101169|PMID:10330154]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10101169]
experiment: EXISTENCE:mutant phenotype:GO:0032448 DNA hairpin binding [PMID:23344960]
experiment: EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:23355394]
note: ATP-dependent 5'-flap endonuclease and DNA helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; cell cycle-dependent localization to telomeric chromatin and replicating chromosomes; required for telomerase-dependent telomere synthesis; stability, localization and nuclease activity regulated by sumoylation; forms nuclear foci upon replication stress; human homolog DNA2 complements yeast dna2 mutant
codon start: 1
product: bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2
translation: MPGTPQKNKRSASISVSPAKKTEEKEIIQNDSKAILSKQTKRKKKYAFAPINNLNGKNTKVSNASVLKSIAVSQVRNTSRTKDINKAVSKSVKQLPNSQVKPKREMSNLSRHHDFTQDEDGPMEEVIWKYSPLQRDMSDKTTSAAEYSDDYEDVQNPSSTPIVPNRLKTVLSFTNIQVPNADVNQLIQENGNEQVRPKPAEISTRESLRNIDDILDDIEGDLTIKPTITKFSDLPSSPIKAPNVEKKAEVNAEEVDKMDSTGDSNDGDDSLIDILTQKYVEKRKSESQITIQGNTNQKSGAQESCGKNDNTKSRGEIEDHENVDNQAKTGNAFYENEEDSNCQRIKKNEKIEYNSSDEFSDDSLIELLNETQTQVEPNTIEQDLDKVEKMVSDDLRIATDSTLSAYALRAKSGAPRDGVVRLVIVSLRSVELPKIGTQKILECIDGKGEQSSVVVRHPWVYLEFEVGDVIHIIEGKNIENKRLLSDDKNPKTQLANDNLLVLNPDVLFSATSVGSSVGCLRRSILQMQFQDPRGEPSLVMTLGNIVHELLQDSIKYKLSHNKISMEIIIQKLDSLLETYSFSIIICNEEIQYVKELVMKEHAENILYFVNKFVSKSNYGCYTSISGTRRTQPISISNVIDIEENIWSPIYGLKGFLDATVEANVENNKKHIVPLEVKTGKSRSVSYEVQGLIYTLLLNDRYEIPIEFFLLYFTRDKNMTKFPSVLHSIKHILMSRNRMSMNFKHQLQEVFGQAQSRFELPPLLRDSSCDSCFIKESCMVLNKLLEDGTPEESGLVEGEFEILTNHLSQNLANYKEFFTKYNDLITKEESSITCVNKELFLLDGSTRESRSGRCLSGLVVSEVVEHEKTEGAYIYCFSRRRNDNNSQSMLSSQIAANDFVIISDEEGHFCLCQGRVQFINPAKIGISVKRKLLNNRLLDKEKGVTTIQSVVESELEQSSLIATQNLVTYRIDKNDIQQSLSLARFNLLSLFLPAVSPGVDIVDERSKLCRKTKRSDGGNEILRSLLVDNRAPKFRDANDDPVIPYKLSKDTTLNLNQKEAIDKVMRAEDYALILGMPGTGKTTVIAEIIKILVSEGKRVLLTSYTHSAVDNILIKLRNTNISIMRLGMKHKVHPDTQKYVPNYASVKSYNDYLSKINSTSVVATTCLGINDILFTLNEKDFDYVILDEASQISMPVALGPLRYGNRFIMVGDHYQLPPLVKNDAARLGGLEESLFKTFCEKHPESVAELTLQYRMCGDIVTLSNFLIYDNKLKCGNNEVFAQSLELPMPEALSRYRNESANSKQWLEDILEPTRKVVFLNYDNCPDIIEQSEKDNITNHGEAELTLQCVEGMLLSGVPCEDIGVMTLYRAQLRLLKKIFNKNVYDGLEILTADQFQGRDKKCIIISMVRRNSQLNGGALLKELRRVNVAMTRAKSKLIIIGSKSTIGSVPEIKSFVNLLEERNWVYTMCKDALYKYKFPDRSNAIDEARKGCGKRTGAKPITSKSKFVSDKPIIKEILQEYES
SIO_010081: YHR164C
subclass of: SO_0000673
so part of: YHR164C
location: complement(424610..429178)
location: region:424610-429178:-1
so has part: feature:424610-429178:-1:exon

NP_012034.1
type: Protein
SIO_000068: ncbiprotein

S000001207
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424610-429178:-1:exon

YHR165C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DBF3
alternative label: DNA39
alternative label: RNA8
alternative label: SLT21
alternative label: USA2
gene: PRP8
locus tag: YHR165C
gene synonym: DBF3; DNA39; RNA8; SLT21; USA2
so part of: sequence
location: complement(<429707..>436948)
location: region:429707-436948:-1
so has part: feature:429707-436948:-1:exon
subclass of: SO_0000010

856570
type: Gene
SIO_000068: ncbigene

position:429707:-1
position: 429707
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436948:-1
position: 436948
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:429707-436948:-1:exon

YHR165C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DBF3
alternative label: DNA39
alternative label: RNA8
alternative label: SLT21
alternative label: USA2
gene: PRP8
locus tag: YHR165C
gene synonym: DBF3; DNA39; RNA8; SLT21; USA2
product: U4/U6-U5 snRNP complex subunit PRP8
transcript id: NM_001179296.1
SIO_010081: YHR165C
subclass of: SO_0000673
so part of: YHR165C
location: complement(<429707..>436948)
location: region:429707-436948:-1
so has part: feature:429707-436948:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:429707-436948:-1:exon

YHR165C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DBF3
alternative label: DNA39
alternative label: RNA8
alternative label: SLT21
alternative label: USA2
gene: PRP8
locus tag: YHR165C
gene synonym: DBF3; DNA39; RNA8; SLT21; USA2
experiment: EXISTENCE:direct assay:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:23393194]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17934474|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:17934474|PMID:11720284|PMID:11720285]
experiment: EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:23393194]
experiment: EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:23393194]
experiment: EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:23393194]
experiment: EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:23393194|PMID:9848662]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:17934474|PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:0097157 pre-mRNA intronic binding [PMID:23393194]
experiment: EXISTENCE:mutant phenotype:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:17934474]
experiment: EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:22408182|PMID:26968627]
experiment: EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:17626844]
experiment: EXISTENCE:mutant phenotype:GO:0000389 mRNA 3'-splice site recognition [PMID:10628969]
experiment: EXISTENCE:mutant phenotype:GO:0000395 mRNA 5'-splice site recognition [PMID:29487104]
note: Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer
codon start: 1
product: U4/U6-U5 snRNP complex subunit PRP8
translation: MSGLPPPPPGFEEDSDLALPPPPPPPPGYEIEELDNPMVPSSVNEDTFLPPPPPPPSNFEINAEEIVDFTLPPPPPPPGLDELETKAEKKVELHGKRKLDIGKDTFVTRKSRKRAKKMTKKAKRSNLYTPKAEMPPEHLRKIINTHSDMASKMYNTDKKAFLGALKYLPHAILKLLENMPHPWEQAKEVKVLYHTSGAITFVNETPRVIEPVYTAQWSATWIAMRREKRDRTHFKRMRFPPFDDDEPPLSYEQHIENIEPLDPINLPLDSQDDEYVKDWLYDSRPLEEDSKKVNGTSYKKWSFDLPEMSNLYRLSTPLRDEVTDKNYYYLFDKKSFFNGKALNNAIPGGPKFEPLYPREEEEDYNEFNSIDRVIFRVPIRSEYKVAFPHLYNSRPRSVRIPWYNNPVSCIIQNDEEYDTPALFFDPSLNPIPHFIDNNSSLNVSNTKENGDFTLPEDFAPLLAEEEELILPNTKDAMSLYHSPFPFNRTKGKMVRAQDVALAKKWFLQHPDEEYPVKVKVSYQKLLKNYVLNELHPTLPTNHNKTKLLKSLKNTKYFQQTTIDWVEAGLQLCRQGHNMLNLLIHRKGLTYLHLDYNFNLKPTKTLTTKERKKSRLGNSFHLMRELLKMMKLIVDTHVQFRLGNVDAFQLADGIHYILNHIGQLTGIYRYKYKVMHQIRACKDLKHIIYYKFNKNLGKGPGCGFWQPAWRVWLNFLRGTIPLLERYIGNLITRQFEGRSNEIVKTTTKQRLDAYYDLELRNSVMDDILEMMPESIRQKKARTILQHLSEAWRCWKANIPWDVPGMPAPIKKIIERYIKSKADAWVSAAHYNRERIKRGAHVEKTMVKKNLGRLTRLWIKNEQERQRQIQKNGPEITPEEATTIFSVMVEWLESRSFSPIPFPPLTYKNDTKILVLALEDLKDVYASKVRLNASEREELALIEEAYDNPHDTLNRIKKYLLTQRVFKPVDITMMENYQNISPVYSVDPLEKITDAYLDQYLWYEADQRKLFPNWIKPSDSEIPPLLVYKWTQGINNLSEIWDVSRGQSAVLLETTLGEMAEKIDFTLLNRLLRLIVDPNIADYITAKNNVVINFKDMSHVNKYGLIRGLKFASFIFQYYGLVIDLLLLGQERATDLAGPANNPNEFMQFKSKEVEKAHPIRLYTRYLDRIYMLFHFEEDEGEELTDEYLAENPDPNFENSIGYNNRKCWPKDSRMRLIRQDVNLGRAVFWEIQSRVPTSLTSIKWENAFVSVYSKNNPNLLFSMCGFEVRILPRQRMEEVVSNDEGVWDLVDERTKQRTAKAYLKVSEEEIKKFDSRIRGILMASGSTTFTKVAAKWNTSLISLFTYFREAIVATEPLLDILVKGETRIQNRVKLGLNSKMPTRFPPAVFYTPKELGGLGMISASHILIPASDLSWSKQTDTGITHFRAGMTHEDEKLIPTIFRYITTWENEFLDSQRVWAEYATKRQEAIQQNRRLAFEELEGSWDRGIPRISTLFQRDRHTLAYDRGHRIRREFKQYSLERNSPFWWTNSHHDGKLWNLNAYRTDVIQALGGIETILEHTLFKGTGFNSWEGLFWEKASGFEDSMQFKKLTHAQRTGLSQIPNRRFTLWWSPTINRANVYVGFLVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESIVFDICQILDGELDVLQIESVTKETVHPRKSYKMNSSAADITMESVHEWEVSKPSLLHETNDSFKGLITNKMWFDVQLRYGDYDSHDISRYVRAKFLDYTTDNVSMYPSPTGVMIGIDLAYNMYDAYGNWFNGLKPLIQNSMRTIMKANPALYVLRERIRKGLQIYQSSVQEPFLNSSNYAELFNNDIKLFVDDTNVYRVTVHKTFEGNVATKAINGCIFTLNPKTGHLFLKIIHTSVWAGQKRLSQLAKWKTAEEVSALVRSLPKEEQPKQIIVTRKAMLDPLEVHMLDFPNIAIRPTELRLPFSAAMSIDKLSDVVMKATEPQMVLFNIYDDWLDRIS…
SIO_010081: YHR165C
subclass of: SO_0000673
so part of: YHR165C
location: complement(429707..436948)
location: region:429707-436948:-1
so has part: feature:429707-436948:-1:exon

NP_012035.1
type: Protein
SIO_000068: ncbiprotein

S000001208
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:429707-436948:-1:exon

YHR166C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CDC23
locus tag: YHR166C
so part of: sequence
location: complement(<437170..>439050)
location: region:437170-439050:-1
so has part: feature:437170-439050:-1:exon
subclass of: SO_0000010

856571
type: Gene
SIO_000068: ncbigene

position:437170:-1
position: 437170
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439050:-1
position: 439050
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437170-439050:-1:exon

YHR166C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CDC23
locus tag: YHR166C
product: anaphase promoting complex subunit CDC23
transcript id: NM_001179297.1
SIO_010081: YHR166C
subclass of: SO_0000673
so part of: YHR166C
location: complement(<437170..>439050)
location: region:437170-439050:-1
so has part: feature:437170-439050:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437170-439050:-1:exon

YHR166C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CDC23
locus tag: YHR166C
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]
experiment: EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]
experiment: EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:12413490]
note: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
codon start: 1
product: anaphase promoting complex subunit CDC23
translation: MNDDSQDKIIHDIRIQLRKAATELSRWKLYGSSKWAAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKQMFEIPQNGFGLSETEYDLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGKFTDEMYRANKDGDGSGNEDINQSGHQRANLKMVSNEHESQSNISSILKEINTFLESYEIKIDDDEADLGLALLYYLRGVILKQEKNISKAMSSFLKSLSCYSFNWSCWLELMDCLQKVDDALLLNNYLYQNFQFKFSENLGSQRTIEFNIMIKFFKLKVFEELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQDPYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEELLEGIVTDETVKARLWLAIFEIKAGNYQLAYDYAMGVSSGTSQEIEEARMLARECRRHM
SIO_010081: YHR166C
subclass of: SO_0000673
so part of: YHR166C
location: complement(437170..439050)
location: region:437170-439050:-1
so has part: feature:437170-439050:-1:exon

NP_012036.1
type: Protein
SIO_000068: ncbiprotein

S000001209
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437170-439050:-1:exon

YHR167W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THP2
locus tag: YHR167W
so part of: sequence
location: <439342..>440127
location: region:439342-440127:1
so has part: feature:439342-440127:1:exon
subclass of: SO_0000010

856572
type: Gene
SIO_000068: ncbigene

position:439342:1
position: 439342
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440127:1
position: 440127
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439342-440127:1:exon

YHR167W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THP2
locus tag: YHR167W
product: Thp2p
transcript id: NM_001179298.1
SIO_010081: YHR167W
subclass of: SO_0000673
so part of: YHR167W
location: <439342..>440127
location: region:439342-440127:1
so has part: feature:439342-440127:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439342-440127:1:exon

YHR167W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THP2
locus tag: YHR167W
experiment: EXISTENCE:direct assay:GO:0000445 THO complex part of transcription export complex [PMID:11979277]
experiment: EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]
experiment: EXISTENCE:mutant phenotype:GO:0000445 THO complex part of transcription export complex [PMID:11979277]
experiment: EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:24084588]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:12093753]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]
note: Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
codon start: 1
product: Thp2p
translation: MTKEEGRTYFESLCEEEQSLQESQTHLLNILDILSVLADPRSSDDLLTESLKKLPDLHRELINSSIRLRYDKYQTREAQLLEDTKTGRDVAAGVQNPKSISEYYSTFEHLNRDTLRYINLLKRLSVDLAKQVEVSDPSVTVYEMDKWVPSEKLQGILEQYCAPDTDIRGVDAQIKNYLDQIKMARAKFGLENKYSLKERLSTLTKELNHWRKEWDDIEMLMFGDDAHSMKKMIQKIDSLKSEINAPSESYPVDKEGDIVLE
SIO_010081: YHR167W
subclass of: SO_0000673
so part of: YHR167W
location: 439342..440127
location: region:439342-440127:1
so has part: feature:439342-440127:1:exon

NP_012037.1
type: Protein
SIO_000068: ncbiprotein

S000001210
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439342-440127:1:exon

YHR168W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTG2
locus tag: YHR168W
so part of: sequence
location: <440377..>441933
location: region:440377-441933:1
so has part: feature:440377-441933:1:exon
subclass of: SO_0000010

856573
type: Gene
SIO_000068: ncbigene

position:440377:1
position: 440377
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:441933:1
position: 441933
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440377-441933:1:exon

YHR168W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTG2
locus tag: YHR168W
product: putative GTPase MTG2
transcript id: NM_001179299.2
SIO_010081: YHR168W
subclass of: SO_0000673
so part of: YHR168W
location: <440377..>441933
location: region:440377-441933:1
so has part: feature:440377-441933:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440377-441933:1:exon

YHR168W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTG2
locus tag: YHR168W
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15591131]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:15591131]
experiment: EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:15591131]
note: Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
codon start: 1
product: putative GTPase MTG2
translation: MSIAWSSVFKRELRLERFLPRVYSTKVPDNAPRAADNEQWLETLRPITHPEQKKSDHDVSYTRHINVPLGEVTSVNYLQRYNKHKHSQGNFVDVRIVKCKSGAGGSGAVSFFRDAGRSIGPPDGGDGGAGGSVYIQAVAGLGSLAKMKTTYTAEDGEAGAARQLDGMRGRDVLIQVPVGTVVKWCLPPQKVRELVEREMRKDNNATLRSILGSTAVNLSVSSGSHRKKIQLYRHEMAESWLFKDKAKEYHENKDWFKDLHKKMEAYDHSLEQSELFNDQFPLAGLDLNQPMTKPVCLLKGGQGGLGNMHFLTNLIRNPRFSKPGRNGLEQHFLFELKSIADLGLIGLPNAGKSTILNKISNAKPKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPISALREENIDVLKKKMFKCARQSEFDK
SIO_010081: YHR168W
subclass of: SO_0000673
so part of: YHR168W
location: 440377..441933
location: region:440377-441933:1
so has part: feature:440377-441933:1:exon

NP_012038.2
type: Protein
SIO_000068: ncbiprotein

S000001211
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440377-441933:1:exon

YHR169W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DBP8
locus tag: YHR169W
so part of: sequence
location: <442181..>443476
location: region:442181-443476:1
so has part: feature:442181-443476:1:exon
subclass of: SO_0000010

856574
type: Gene
SIO_000068: ncbigene

position:442181:1
position: 442181
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:443476:1
position: 443476
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442181-443476:1:exon

YHR169W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DBP8
locus tag: YHR169W
product: ATP-dependent RNA helicase DBP8
transcript id: NM_001179300.1
SIO_010081: YHR169W
subclass of: SO_0000673
so part of: YHR169W
location: <442181..>443476
location: region:442181-443476:1
so has part: feature:442181-443476:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:442181-443476:1:exon

YHR169W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DBP8
locus tag: YHR169W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11222764]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16772403]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]
experiment: EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:11222764]
note: ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p
codon start: 1
product: ATP-dependent RNA helicase DBP8
translation: MADFKSLGLSKWLTESLRAMKITQPTAIQKACIPKILEGRDCIGGAKTGSGKTIAFAGPMLTKWSEDPSGMFGVVLTPTRELAMQIAEQFTALGSSMNIRVSVIVGGESIVQQALDLQRKPHFIIATPGRLAHHIMSSGDDTVGGLMRAKYLVLDEADILLTSTFADHLATCISALPPKDKRQTLLFTATITDQVKSLQNAPVQKGKPPLFAYQVESVDNVAIPSTLKIEYILVPEHVKEAYLYQLLTCEEYENKTAIIFVNRTMTAEILRRTLKQLEVRVASLHSQMPQQERTNSLHRFRANAARILIATDVASRGLDIPTVELVVNYDIPSDPDVFIHRSGRTARAGRIGDAISFVTQRDVSRIQAIEDRINKKMTETNKVHDTAVIRKALTKVTKAKRESLMAMQKENFGERKRQQKKKQNDGKSLRS
SIO_010081: YHR169W
subclass of: SO_0000673
so part of: YHR169W
location: 442181..443476
location: region:442181-443476:1
so has part: feature:442181-443476:1:exon

NP_012039.1
type: Protein
SIO_000068: ncbiprotein

S000001212
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:442181-443476:1:exon

YHR170W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SRC5
gene: NMD3
locus tag: YHR170W
gene synonym: SRC5
so part of: sequence
location: <443828..>445384
location: region:443828-445384:1
so has part: feature:443828-445384:1:exon
subclass of: SO_0000010

856575
type: Gene
SIO_000068: ncbigene

position:443828:1
position: 443828
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:445384:1
position: 445384
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443828-445384:1:exon

YHR170W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SRC5
gene: NMD3
locus tag: YHR170W
gene synonym: SRC5
product: ribosome-binding protein NMD3
transcript id: NM_001179301.1
SIO_010081: YHR170W
subclass of: SO_0000673
so part of: YHR170W
location: <443828..>445384
location: region:443828-445384:1
so has part: feature:443828-445384:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443828-445384:1:exon

YHR170W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SRC5
gene: NMD3
locus tag: YHR170W
gene synonym: SRC5
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10022925]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:11086007|PMID:11313466]
experiment: EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:11105761|PMID:17347149]
experiment: EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:24240281]
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:23212245]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11086007]
note: Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
codon start: 1
product: ribosome-binding protein NMD3
translation: MEFTPIDPHQHQNAATLLCCNCGTPIDGSTGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTISISEAKDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEIVPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNALADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDSVMGYFIANSNYNSDLFDGLNIDYVPDVVLVKKLYQRKSKKSRHWKLKRMAKEHKDIDASLDYNSRAQKQEMERAEKDYELFLQELEEDAELRQSVNLYKNREANVPPEEHEMDEDEDEDAPQINIDELLDELDEMTLEDGVENTPVESQQ
SIO_010081: YHR170W
subclass of: SO_0000673
so part of: YHR170W
location: 443828..445384
location: region:443828-445384:1
so has part: feature:443828-445384:1:exon

NP_012040.1
type: Protein
SIO_000068: ncbiprotein

S000001213
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443828-445384:1:exon

YHR171W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG11
alternative label: APG7
alternative label: CVT2
gene: ATG7
locus tag: YHR171W
gene synonym: APG11; APG7; CVT2
so part of: sequence
location: <445713..>447605
location: region:445713-447605:1
so has part: feature:445713-447605:1:exon
subclass of: SO_0000010

856576
type: Gene
SIO_000068: ncbigene

position:445713:1
position: 445713
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:447605:1
position: 447605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:445713-447605:1:exon

YHR171W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG11
alternative label: APG7
alternative label: CVT2
gene: ATG7
locus tag: YHR171W
gene synonym: APG11; APG7; CVT2
product: Atg7p
transcript id: NM_001179302.1
SIO_010081: YHR171W
subclass of: SO_0000673
so part of: YHR171W
location: <445713..>447605
location: region:445713-447605:1
so has part: feature:445713-447605:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:445713-447605:1:exon

YHR171W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG11
alternative label: APG7
alternative label: CVT2
gene: ATG7
locus tag: YHR171W
gene synonym: APG11; APG7; CVT2
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10233150|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:15277523|PMID:19398890]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:10233148]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:11038174|PMID:12965207|PMID:15277523|PMID:11100732]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:10233150|PMID:12965207]
experiment: EXISTENCE:mutant phenotype:GO:0019778 Atg12 activating enzyme activity [PMID:10233150]
experiment: EXISTENCE:mutant phenotype:GO:0019779 Atg8 activating enzyme activity [PMID:11100732]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10233150|PMID:12965207]
experiment: EXISTENCE:mutant phenotype:GO:0032446 protein modification by small protein conjugation [PMID:10233150]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
note: Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
codon start: 1
product: Atg7p
translation: MSSERVLSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTCQPLTVNLDLHNIPKSADQVPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFLHQRALECWEDGIKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTVLHVRPEPSLKGLFSKCQKWFDVNYSKWVCILDADDEIVNYDKCIIRKTKVLAIRDTSTMENVPSALTKNFLSVLQYDVPDLIDFKLLIIRQNEGSFALNATFASIDPQSSSSNPDMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDLNLKLMKWRILPDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVRQALYNFEDCGKPKAELAAASLKRIFPLMDATGVKLSIPMIGHKLVNEEAQHKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIENKTVINAALGFDSYLVMRHGNRDEQSSKQLGCYFCHDVVAPTDSLTDRTLDQMCTVTRPGVAMMASSLAVELMTSLLQTKYSGSETTVLGDIPHQIRGFLHNFSILKLETPAYEHCPACSPKVIEAFTDLGWEFVKKALEHPLYLEEISGLSVIKQEVERLGNDVFEWEDDESDEIA
SIO_010081: YHR171W
subclass of: SO_0000673
so part of: YHR171W
location: 445713..447605
location: region:445713-447605:1
so has part: feature:445713-447605:1:exon

NP_012041.1
type: Protein
SIO_000068: ncbiprotein

S000001214
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:445713-447605:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS820; Autonomously Replicating Sequence
so part of: sequence
location: 447714..447795
location: region:447714-447795:1
so has part: feature:447714-447795:1:region

S000118361
type: SGD
SIO_000068: sgd

position:447714:1
position: 447714
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:447795:1
position: 447795
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447714-447795:1:region

YHR172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC97
locus tag: YHR172W
so part of: sequence
location: <448335..>450806
location: region:448335-450806:1
so has part: feature:448335-450806:1:exon
subclass of: SO_0000010

856577
type: Gene
SIO_000068: ncbigene

position:448335:1
position: 448335
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:450806:1
position: 450806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448335-450806:1:exon

YHR172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC97
locus tag: YHR172W
product: Spc97p
transcript id: NM_001179303.1
SIO_010081: YHR172W
subclass of: SO_0000673
so part of: YHR172W
location: <448335..>450806
location: region:448335-450806:1
so has part: feature:448335-450806:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:448335-450806:1:exon

YHR172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC97
locus tag: YHR172W
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630|PMID:9130700]
experiment: EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630|PMID:9130700]
experiment: EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:11950928|PMID:24842996]
experiment: EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9130700|PMID:9384578|PMID:25599398]
experiment: EXISTENCE:mutant phenotype:GO:0031122 cytoplasmic microtubule organization [PMID:9670012]
experiment: EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]
experiment: EXISTENCE:physical interaction:GO:0043015 gamma-tubulin binding [PMID:9130700]
note: Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
codon start: 1
product: Spc97p
translation: MEIKEVDDRAELLRYTNNIPLLGKLVNHQPLWSTNPKLKSFSLEKISAPDQRRVQEALVVKDLLNVLIGLEGTYIRYFNDYEPSDPETPIEFKIAKKMDPSFKTFSRRIVRYGKQYMILTRAYEKWSDTSFGMVLQRFAYEIRRFLEDVYLKTLVERLERDFNKVPNFSIRELEQIINETEVNKQMELLYNIYEEIFREIEERRTNQSSQEDFNNFMDSMKNESSLHLRLMVAFDTTVYPVPKGGAILKIFQQKILENLGDRSSVMFLKKLLNNISQDYCTMLYEWLTQGILNDPYQEFMTYDDLEGKTDNIFDTRDRAWDTQYFIRKDVLLRDCDSEEDKNLLFKMLRTGILLKVVRASLQIPTIPSNSSDITIQEINDFADLMEGSNLELYVDKCYSRANEIFLKLFFQGYDLINVLKHLQQIFLGYQSGHNVLKFLTKNMGELTKHYRNDNNANYDKLLQNFELERQSENPNNLMRQLLMIQFDTETLPQVLSHYLQIYPEVPENNSANDDSDPLMHANNFKNMNAILFDELSKERTGAYHGSNLELYTPKSAIYHLKFDINIPYPLNIIISRTCMIKYQIILRYQLVLQYHSRLLDETWMDLNKTPSWKYRGYSHTVKRRIVRATRVLHAKMNHFIKTIMEYFNQNVIDKEVYSLEKCYRNPTLAVAIQNELEGGLTNIMTNRCLSDLIPLQLQIFDIVYKFCKFIKSMRAKLCQLDPVLYEKHKSGMMKTLNEGYRTNNGGQEDVGYQEDAALELIQKLIEYISNASSIFRKCLINFTQELSTEKFDFYDSSSVDAAGIERVLYSIVPPRSASASSQR
SIO_010081: YHR172W
subclass of: SO_0000673
so part of: YHR172W
location: 448335..450806
location: region:448335-450806:1
so has part: feature:448335-450806:1:exon

NP_012042.1
type: Protein
SIO_000068: ncbiprotein

S000001215
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:448335-450806:1:exon

YHR173C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR173C
so part of: sequence
location: complement(<450815..>451153)
location: region:450815-451153:-1
so has part: feature:450815-451153:-1:exon
subclass of: SO_0000010

856578
type: Gene
SIO_000068: ncbigene

position:450815:-1
position: 450815
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451153:-1
position: 451153
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450815-451153:-1:exon

YHR173C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR173C
product: uncharacterized protein
transcript id: NM_001270738.1
SIO_010081: YHR173C
subclass of: SO_0000673
so part of: YHR173C
location: complement(<450815..>451153)
location: region:450815-451153:-1
so has part: feature:450815-451153:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450815-451153:-1:exon

YHR173C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR173C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: hypothetical protein; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole
codon start: 1
product: uncharacterized protein
translation: MLFFFIYAWCHLSHTILQPSTKIQMIVRSKPESNGEKKLMNHDEPNDQYNQRNYPSEVYADLVSHFMNFAYGKVHESGLQKKGVRCVDVSISGCQFWNGIPLSASWCTSLVT
SIO_010081: YHR173C
subclass of: SO_0000673
so part of: YHR173C
location: complement(450815..451153)
location: region:450815-451153:-1
so has part: feature:450815-451153:-1:exon

NP_001257667.1
type: Protein
SIO_000068: ncbiprotein

S000001216
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450815-451153:-1:exon

YHR174W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENO2
locus tag: YHR174W
so part of: sequence
location: <451327..>452640
location: region:451327-452640:1
so has part: feature:451327-452640:1:exon
subclass of: SO_0000010

856579
type: Gene
SIO_000068: ncbigene

position:451327:1
position: 451327
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:452640:1
position: 452640
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451327-452640:1:exon

YHR174W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENO2
locus tag: YHR174W
product: phosphopyruvate hydratase ENO2
transcript id: NM_001179305.1
SIO_010081: YHR174W
subclass of: SO_0000673
so part of: YHR174W
location: <451327..>452640
location: region:451327-452640:1
so has part: feature:451327-452640:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:451327-452640:1:exon

YHR174W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENO2
locus tag: YHR174W
EC number: 4.2.1.11
experiment: EXISTENCE:direct assay:GO:0000015 phosphopyruvate hydratase complex [PMID:6282834]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:16544286]
experiment: EXISTENCE:direct assay:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]
experiment: EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]
experiment: EXISTENCE:mutant phenotype:GO:0004634 phosphopyruvate hydratase activity [PMID:6282834]
experiment: EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:6282834]
experiment: EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]
note: Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; mRNA is asymmetrically distributed to daughter cells in a Sir2p-dependent manner, and asymmetry is lost during replicative aging; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication
codon start: 1
product: phosphopyruvate hydratase ENO2
translation: MAVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRDEDKSKWMGKGVMNAVNNVNNVIAAAFVKANLDVKDQKAVDDFLLSLDGTANKSKLGANAILGVSMAAARAAAAEKNVPLYQHLADLSKSKTSPYVLPVPFLNVLNGGSHAGGALALQEFMIAPTGAKTFAEAMRIGSEVYHNLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKVKIGLDCASSEFFKDGKYDLDFKNPESDKSKWLTGVELADMYHSLMKRYPIVSIEDPFAEDDWEAWSHFFKTAGIQIVADDLTVTNPARIATAIEKKAADALLLKVNQIGTLSESIKAAQDSFAANWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAKLNQLLRIEEELGDKAVYAGENFHHGDKL
SIO_010081: YHR174W
subclass of: SO_0000673
so part of: YHR174W
location: 451327..452640
location: region:451327-452640:1
so has part: feature:451327-452640:1:exon

NP_012044.1
type: Protein
SIO_000068: ncbiprotein

S000001217
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451327-452640:1:exon

YHR175W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTR2
locus tag: YHR175W
so part of: sequence
location: <452872..>453441
location: region:452872-453441:1
so has part: feature:452872-453441:1:exon
subclass of: SO_0000010

856580
type: Gene
SIO_000068: ncbigene

position:452872:1
position: 452872
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453441:1
position: 453441
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:452872-453441:1:exon

YHR175W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTR2
locus tag: YHR175W
product: low-affinity Cu transporter
transcript id: NM_001179306.3
SIO_010081: YHR175W
subclass of: SO_0000673
so part of: YHR175W
location: <452872..>453441
location: region:452872-453441:1
so has part: feature:452872-453441:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:452872-453441:1:exon

YHR175W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTR2
locus tag: YHR175W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11523804]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0005375 copper ion transmembrane transporter activity [PMID:7499355]
experiment: EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:7499355]
experiment: EXISTENCE:mutant phenotype:GO:0005375 copper ion transmembrane transporter activity [PMID:11523804]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:23450501]
experiment: EXISTENCE:mutant phenotype:GO:0015680 protein maturation by copper ion transfer [PMID:11523804]
note: Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway
codon start: 1
product: low-affinity Cu transporter
translation: MDDKKTWSTVTLRTFNQLVTSSLIGYSKKMDSMNHKMEGNAGHDHSDMHMGDGDDTCSMNMLFSWSYKNTCVVFEWWHIKTLPGLILSCLAIFGLAYLYEYLKYCVHKRQLSQRVLLPNRSLTKINQADKVSNSILYGLQVGFSFMLMLVFMTYNGWLMLAVVCGAIWGNYSWCTSYSPEIDDSSLACH
SIO_010081: YHR175W
subclass of: SO_0000673
so part of: YHR175W
location: 452872..453441
location: region:452872-453441:1
so has part: feature:452872-453441:1:exon

NP_012045.3
type: Protein
SIO_000068: ncbiprotein

S000001218
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:452872-453441:1:exon

YHR175W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR175W-A
so part of: sequence
location: <453558..>453707
location: region:453558-453707:1
so has part: feature:453558-453707:1:exon
subclass of: SO_0000010

1466530
type: Gene
SIO_000068: ncbigene

position:453558:1
position: 453558
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453707:1
position: 453707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:453558-453707:1:exon

YHR175W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR175W-A
product: uncharacterized protein
transcript id: NM_001184554.1
SIO_010081: YHR175W-A
subclass of: SO_0000673
so part of: YHR175W-A
location: <453558..>453707
location: region:453558-453707:1
so has part: feature:453558-453707:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:453558-453707:1:exon

YHR175W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR175W-A
note: hypothetical protein; identified by fungal homology and RT-PCR
codon start: 1
product: uncharacterized protein
translation: MINYVNITCIIFSTRTLLVFDTSLYIPPFMLSFIGYSLSNQNSPLFLYH
SIO_010081: YHR175W-A
subclass of: SO_0000673
so part of: YHR175W-A
location: 453558..453707
location: region:453558-453707:1
so has part: feature:453558-453707:1:exon

NP_878090.1
type: Protein
SIO_000068: ncbiprotein

S000028553
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:453558-453707:1:exon

YHR176W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMO1
locus tag: YHR176W
so part of: sequence
location: <454229..>455527
location: region:454229-455527:1
so has part: feature:454229-455527:1:exon
subclass of: SO_0000010

856581
type: Gene
SIO_000068: ncbigene

position:454229:1
position: 454229
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:455527:1
position: 455527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454229-455527:1:exon

YHR176W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMO1
locus tag: YHR176W
product: N,N-dimethylaniline monooxygenase
transcript id: NM_001179307.3
SIO_010081: YHR176W
subclass of: SO_0000673
so part of: YHR176W
location: <454229..>455527
location: region:454229-455527:1
so has part: feature:454229-455527:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454229-455527:1:exon

YHR176W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMO1
locus tag: YHR176W
experiment: EXISTENCE:direct assay:GO:0004499 N,N-dimethylaniline monooxygenase activity [PMID:10600176]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10077572]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006457 protein folding [PMID:10077572]
note: Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
codon start: 1
product: N,N-dimethylaniline monooxygenase
translation: MTVNDKKRLAIIGGGPGGLAAARVFSQSLPNFEIEIFVKDYDIGGVWHYPEQKSDGRVMYDHLETNISKKLMQFSGFPFEENVPLYPSRRNIWEYLKAYYKTFIANKDAISIHFSTEVTYLKKKNSQWEITSKDELRTTKSDFDFVIVASGHYSVPKLPTNIAGLDLWFDNKGAFHSKDFKNCEFAREKVVIVVGNGSSGQDIANQLTTVAKKVYNSIKEPASNQLKAKLIETVQTIDSADWKNRSVTLSDGRVLQNIDYIIFATGYYYSFPFIEPSVRLEVLGEGVTGDKHSSVNLHNLWEHMIYVKDPTLSFILTPQLVIPFPLSELQAAIMVEVFCKSLPITTTFDSNACGTHNFPKGKDLEYYAELQELLNSIPRRVGHFEPVVWDDRLIDLRNSSYTDKEERNVLLAEHAQALKKKKAPYFLPAPHT
SIO_010081: YHR176W
subclass of: SO_0000673
so part of: YHR176W
location: 454229..455527
location: region:454229-455527:1
so has part: feature:454229-455527:1:exon

NP_012046.4
type: Protein
SIO_000068: ncbiprotein

S000001219
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454229-455527:1:exon

YHR177W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ROF1
locus tag: YHR177W
so part of: sequence
location: <456591..>457952
location: region:456591-457952:1
so has part: feature:456591-457952:1:exon
subclass of: SO_0000010

856582
type: Gene
SIO_000068: ncbigene

position:456591:1
position: 456591
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457952:1
position: 457952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:456591-457952:1:exon

YHR177W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ROF1
locus tag: YHR177W
product: Rof1p
transcript id: NM_001179308.1
SIO_010081: YHR177W
subclass of: SO_0000673
so part of: YHR177W
location: <456591..>457952
location: region:456591-457952:1
so has part: feature:456591-457952:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:456591-457952:1:exon

YHR177W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ROF1
locus tag: YHR177W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:24994900]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24994900]
note: Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest
codon start: 1
product: Rof1p
translation: MMDISPTCYGYIDDEQDLALVFQGVFNGNLRCIERRPYDAEKVELVNPGNIFVFNEEKSGIKRWTDGFSWSPSRISGKFLVYREYNRLGSTHDLPLHNVPEYNIFERAHRKYFYTGLLKKTFSLKFNMDPTDSTKLETFHLIAYYTEKDIHQGSLRRPSENPFFHKFRPSQKLLDALQKVAVGNGRSNPSKNNERGRTKAHNYKTRRSLSSSPSYCDLLSNYNNHPGNIPVRTAVQLPLTTFNNAPREMHQQQHRQQQQYLLPIDEQNKLPLPYMQHQPQPIGVYNPNYQPGLRRTVSQPMIFCNTYNTLPQQPTAAPYERRGVSPSVIYSSNTLSPIPYQNIDPYSSRSGPECNHSKAPIAPTMMPPVHHILVHDYRQPKPVTDSINPPNVNITTSTTNKNLDGIYILPAPRMNPPAQTQYQMIHAPDSMQHPPTFSKNNTSSNPKSHQYSK
SIO_010081: YHR177W
subclass of: SO_0000673
so part of: YHR177W
location: 456591..457952
location: region:456591-457952:1
so has part: feature:456591-457952:1:exon

NP_012047.1
type: Protein
SIO_000068: ncbiprotein

S000001220
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:456591-457952:1:exon

YHR178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STB5
locus tag: YHR178W
so part of: sequence
location: <459299..>461530
location: region:459299-461530:1
so has part: feature:459299-461530:1:exon
subclass of: SO_0000010

856583
type: Gene
SIO_000068: ncbigene

position:459299:1
position: 459299
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461530:1
position: 461530
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459299-461530:1:exon

YHR178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STB5
locus tag: YHR178W
product: Stb5p
transcript id: NM_001179309.3
SIO_010081: YHR178W
subclass of: SO_0000673
so part of: YHR178W
location: <459299..>461530
location: region:459299-461530:1
so has part: feature:459299-461530:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:459299-461530:1:exon

YHR178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STB5
locus tag: YHR178W
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11943786]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:11943786]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11943786]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:11943786]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16914749]
note: Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
codon start: 1
product: Stb5p
translation: MDGPNFAHQGGRSQRTTELYSCARCRKLKKKCGKQIPTCANCDKNGAHCSYPGRAPRRTKKELADAMLRGEYVPVKRNKKVGKSPLSTKSMPNSSSPLSANGAITPGFSPYENDDAHKMKQLKPSDPINLVMGASPNSSEGVSSLISVLTSLNDNSNPSSHLSSNENSMIPSRSLPASVQQSSTTSSFGGYNTPSPLISSHVPANAQAVPLQNNNRNTSNGDNGSNVNHDNNNGSTNTPQLSLTPYANNSAPNGKFDSVPVDASSIEFETMSCCFKGGRTTSWVREDGSFKSIDRSLLDRFIAAYFKHNHRLFPMIDKIAFLNDAATITDFERLYDNKNYPDSFVFKVYMIMAIGCTTLQRAGMVSQDEECLSEHLAFLAMKKFRSVIILQDIETVRCLLLLGIYSFFEPKGSSSWTISGIIMRLTIGLGLNRELTAKKLKSMSALEAEARYRVFWSAYCFERLVCTSLGRISGIDDEDITVPLPRALYVDERDDLEMTKLMISLRKMGGRIYKQVHSVSAGRQKLTIEQKQEIISGLRKELDEIYSRESERRKLKKSQMDQVERENNSTTNVISFHSSEIWLAMRYSQLQILLYRPSALMPKPPIDSLSTLGEFCLQAWKHTYTLYKKRLLPLNWITLFRTLTICNTILYCLCQWSIDLIESKIEIQQCVEILRHFGERWIFAMRCADVFQNISNTILDISLSHGKVPNMDQLTRELFGASDSYQDILDENNVDVSWVDKLV
SIO_010081: YHR178W
subclass of: SO_0000673
so part of: YHR178W
location: 459299..461530
location: region:459299-461530:1
so has part: feature:459299-461530:1:exon

NP_012048.3
type: Protein
SIO_000068: ncbiprotein

S000001221
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459299-461530:1:exon

YHR179W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OYE2
locus tag: YHR179W
so part of: sequence
location: <462502..>463704
location: region:462502-463704:1
so has part: feature:462502-463704:1:exon
subclass of: SO_0000010

856584
type: Gene
SIO_000068: ncbigene

position:462502:1
position: 462502
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:463704:1
position: 463704
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462502-463704:1:exon

YHR179W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OYE2
locus tag: YHR179W
product: NADPH dehydrogenase
transcript id: NM_001179310.1
SIO_010081: YHR179W
subclass of: SO_0000673
so part of: YHR179W
location: <462502..>463704
location: region:462502-463704:1
so has part: feature:462502-463704:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462502-463704:1:exon

YHR179W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OYE2
locus tag: YHR179W
EC number: 1.6.99.1
experiment: EXISTENCE:direct assay:GO:0003959 NADPH dehydrogenase activity [PMID:8454584]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:17897954]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17897954]
note: Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress
codon start: 1
product: NADPH dehydrogenase
translation: MPFVKDFKPQALGDTNLFKPIKIGNNELLHRAVIPPLTRMRAQHPGNIPNRDWAVEYYAQRAQRPGTLIITEGTFPSPQSGGYDNAPGIWSEEQIKEWTKIFKAIHENKSFAWVQLWVLGWAAFPDTLARDGLRYDSASDNVYMNAEQEEKAKKANNPQHSITKDEIKQYVKEYVQAAKNSIAAGADGVEIHSANGYLLNQFLDPHSNNRTDEYGGSIENRARFTLEVVDAVVDAIGPEKVGLRLSPYGVFNSMSGGAETGIVAQYAYVLGELERRAKAGKRLAFVHLVEPRVTNPFLTEGEGEYNGGSNKFAYSIWKGPIIRAGNFALHPEVVREEVKDPRTLIGYGRFFISNPDLVDRLEKGLPLNKYDRDTFYKMSAEGYIDYPTYEEALKLGWDKN
SIO_010081: YHR179W
subclass of: SO_0000673
so part of: YHR179W
location: 462502..463704
location: region:462502-463704:1
so has part: feature:462502-463704:1:exon

NP_012049.1
type: Protein
SIO_000068: ncbiprotein

S000001222
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462502-463704:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(463920..464147)
location: region:463920-464147:-1
so has part: feature:463920-464147:-1:region

S000006999
type: SGD
SIO_000068: sgd

position:463920:-1
position: 463920
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:464147:-1
position: 464147
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:463920-464147:-1:region

YHR180W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR180W
so part of: sequence
location: <465178..>465669
location: region:465178-465669:1
so has part: feature:465178-465669:1:exon
subclass of: SO_0000010

856585
type: Gene
SIO_000068: ncbigene

position:465178:1
position: 465178
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:465669:1
position: 465669
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465178-465669:1:exon

YHR180W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR180W
product: uncharacterized protein
transcript id: NM_001348842.1
SIO_010081: YHR180W
subclass of: SO_0000673
so part of: YHR180W
location: <465178..>465669
location: region:465178-465669:1
so has part: feature:465178-465669:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465178-465669:1:exon

YHR180W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR180W
note: hypothetical protein; conserved among S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MEMHWITLVAFIATFFNLAATSINNSSLPDVDLTNPLRFFTNIPAGLNFNEVIFLERNGFYLGGIDSPSIYHLINGTAVYFGDVRDNIMPGTVGTTRNVTDVDYGSLLTEYGYEANTDYVSRWIATHVVISPLNATEFFQTPVPVPVPVPITILHQQVNSKLH
SIO_010081: YHR180W
subclass of: SO_0000673
so part of: YHR180W
location: 465178..465669
location: region:465178-465669:1
so has part: feature:465178-465669:1:exon

NP_001335743.1
type: Protein
SIO_000068: ncbiprotein

S000001223
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465178-465669:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 466549..466863
location: region:466549-466863:1
so has part: feature:466549-466863:1:region

S000007009
type: SGD
SIO_000068: sgd

position:466549:1
position: 466549
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:466863:1
position: 466863
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466549-466863:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(466884..466975)
location: region:466884-466975:-1
so has part: feature:466884-466975:-1:region

S000007004
type: SGD
SIO_000068: sgd

position:466884:-1
position: 466884
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:466975:-1
position: 466975
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466884-466975:-1:region

YNCH0015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0015W
so part of: sequence
location: 466990..467061
location: region:466990-467061:1
so has part: feature:466990-467061:1:exon
subclass of: SO_0000663

856586
type: Gene
SIO_000068: ncbigene

position:466990:1
position: 466990
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:467061:1
position: 467061
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466990-467061:1:exon

YNCH0015W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0015W
product: tRNA-Thr
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Threonine tRNA (tRNA-Thr), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0015W
subclass of: SO_0000673
so part of: YNCH0015W
location: 466990..467061
location: region:466990-467061:1
so has part: feature:466990-467061:1:exon

S000006751
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466990-467061:1:exon

YHR181W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ERV26
gene: SVP26
locus tag: YHR181W
gene synonym: ERV26
so part of: sequence
location: <467228..>467914
location: region:467228-467914:1
so has part: feature:467228-467914:1:exon
subclass of: SO_0000010

856587
type: Gene
SIO_000068: ncbigene

position:467228:1
position: 467228
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:467914:1
position: 467914
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:467228-467914:1:exon

YHR181W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ERV26
gene: SVP26
locus tag: YHR181W
gene synonym: ERV26
product: Svp26p
transcript id: NM_001179312.3
SIO_010081: YHR181W
subclass of: SO_0000673
so part of: YHR181W
location: <467228..>467914
location: region:467228-467914:1
so has part: feature:467228-467914:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:467228-467914:1:exon

YHR181W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ERV26
gene: SVP26
locus tag: YHR181W
gene synonym: ERV26
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16957051]
experiment: EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:16957051]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:16957051]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:30842360|PMID:16957051]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:16107716]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:16107716]
experiment: EXISTENCE:mutant phenotype:GO:0090110 COPII-coated vesicle cargo loading [PMID:30842360]
experiment: EXISTENCE:mutant phenotype:GO:0097020 COPII receptor activity [PMID:20236934]
experiment: EXISTENCE:physical interaction:GO:0097020 COPII receptor activity [PMID:20236934]
note: ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER
codon start: 1
product: Svp26p
translation: MLLELISYAGTVSGFLFLTLSIASGLYYISELVEEHTEPTRRFLTRAIYGIILILILLLLLDGFPFKLTLFSIACYIVYYQNLKSFPFISLTSPTFLLSCVCVVLNHYFWFKYFNDTEVPPQFKFDPNYIPRRRASFAEVASFFGICVWFIPFALFVSLSAGDYVLPTTSEQHMAKKNDDITTNNQPKFRKRAVGLARVVINSVRKYIYSLARVFGYEIEPDFDRLAV
SIO_010081: YHR181W
subclass of: SO_0000673
so part of: YHR181W
location: 467228..467914
location: region:467228-467914:1
so has part: feature:467228-467914:1:exon

NP_012051.3
type: Protein
SIO_000068: ncbiprotein

S000001224
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:467228-467914:1:exon

YHR182W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RGD3
locus tag: YHR182W
so part of: sequence
location: <468219..>470576
location: region:468219-470576:1
so has part: feature:468219-470576:1:exon
subclass of: SO_0000010

856588
type: Gene
SIO_000068: ncbigene

position:468219:1
position: 468219
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:470576:1
position: 470576
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468219-470576:1:exon

YHR182W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RGD3
locus tag: YHR182W
product: Rgd3p
transcript id: NM_001179313.1
SIO_010081: YHR182W
subclass of: SO_0000673
so part of: YHR182W
location: <468219..>470576
location: region:468219-470576:1
so has part: feature:468219-470576:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:468219-470576:1:exon

YHR182W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RGD3
locus tag: YHR182W
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:32941095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32941095]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0030659 cytoplasmic vesicle membrane [PMID:32941095]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:32941095]
experiment: EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:32941095]
note: GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
codon start: 1
product: Rgd3p
translation: MSVKEHNEEDIIGDELQNSRQLSIDCDSVKISLRNTYWTKDYTTGIKLFIKHMKRENDLLIKDIKFYNDFVNKFWKPTLNNLQKMEATNSMNSRLLEVMSKQFNIISTEQVERDCKIPLQELRDLNESFLREAENDLSSRYSAYIKDLVAAKEALIGCEKRVQSIYKLKKANTPVENSSSVFDNGKDSAPLTRLNFVCEFPYTLDERLKFEDCDQFMSFLQTLKGKVILEKSVFSVPGLSNQSFQGRSLIKELKKLEPRLNLSLFNIDRIGNEFIQLGIIQEYSLSFYSSKVSQFDQEKYYYWNSEVLATQESNGNAGNRKKKSYGELTHSDNEHEEKSNVSSIKTSISDWIRKVSQHDNDDCDAAGSTDMNKNEWKSLKQQLESSQDIFFSKCCQLEYSKVQLEKTIYDYCKNYSKMEDGIKRALESSNMMFQQKCEKFTDSPVCSLQEAQLPQETANADVRGFFLRDNGIPFRRWNILEASDPVDACKEISIKSEKFFCGSEINNELAALDTLGAIKIILRQIEKEPNANKVIQSWHRDIDFVRVSNLKRDLLGEFKGSKTTENTNSIITAHFFENSHSYVTNDLVGLIKLWLLELPDSLIPSNHYDDLIKAEKSLTSLCEQFPTSSLRFLQELANHFQLINSKYSLPPQTIQDLFRDNSDIDIPLAHHFVRRTGLQNPIDIKILSPTLSTFFINERTVETLQTLIANRITTATTATLTEPPTIIIKDTTAPIHSTPKPPPNDKDGHFIPRPFKTSSTPTTPERPKRKSGLFLPINVNDVPST
SIO_010081: YHR182W
subclass of: SO_0000673
so part of: YHR182W
location: 468219..470576
location: region:468219-470576:1
so has part: feature:468219-470576:1:exon

NP_012052.1
type: Protein
SIO_000068: ncbiprotein

S000001225
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468219-470576:1:exon

YHR183W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GND1
locus tag: YHR183W
so part of: sequence
location: <470960..>472429
location: region:470960-472429:1
so has part: feature:470960-472429:1:exon
subclass of: SO_0000010

856589
type: Gene
SIO_000068: ncbigene

position:470960:1
position: 470960
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472429:1
position: 472429
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:470960-472429:1:exon

YHR183W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GND1
locus tag: YHR183W
product: phosphogluconate dehydrogenase (decarboxylating) GND1
transcript id: NM_001179314.3
SIO_010081: YHR183W
subclass of: SO_0000673
so part of: YHR183W
location: <470960..>472429
location: region:470960-472429:1
so has part: feature:470960-472429:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:470960-472429:1:exon

YHR183W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GND1
locus tag: YHR183W
EC number: 1.1.1.44
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity [PMID:1328471]
experiment: EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:1328471]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9480895]
note: 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication
codon start: 1
product: phosphogluconate dehydrogenase (decarboxylating) GND1
translation: MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDNLPVDKDIHINWTGHGGNVSSSTYQA
SIO_010081: YHR183W
subclass of: SO_0000673
so part of: YHR183W
location: 470960..472429
location: region:470960-472429:1
so has part: feature:470960-472429:1:exon

NP_012053.3
type: Protein
SIO_000068: ncbiprotein

S000001226
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:470960-472429:1:exon

YHR184W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPO3
gene: SSP1
locus tag: YHR184W
gene synonym: SPO3
so part of: sequence
location: <472744..>474459
location: region:472744-474459:1
so has part: feature:472744-474459:1:exon
subclass of: SO_0000010

856590
type: Gene
SIO_000068: ncbigene

position:472744:1
position: 472744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:474459:1
position: 474459
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472744-474459:1:exon

YHR184W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPO3
gene: SSP1
locus tag: YHR184W
gene synonym: SPO3
product: Ssp1p
transcript id: NM_001179315.1
SIO_010081: YHR184W
subclass of: SO_0000673
so part of: YHR184W
location: <472744..>474459
location: region:472744-474459:1
so has part: feature:472744-474459:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472744-474459:1:exon

YHR184W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPO3
gene: SSP1
locus tag: YHR184W
gene synonym: SPO3
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11742972]
experiment: EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:11742972|PMID:24390141]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11742972]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11742972]
note: Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis
codon start: 1
product: Ssp1p
translation: MRSSGTYENDPSGEITSTSPKQSKQKKPTKFRERMRRWLQNGKNNNHQGEEDVPEIFNKNFYPQTGMTAFNNNDNGEVQDVTNNFFLPSEDESGPVQSSVKTFLTGNNDEDSNFQQNQNPKQKSELPKSPYRQKPTQEIALLKDLFVTNKYDDPYLNSSTRFGNITSTFPSSLSLRTVTLQTIKKRIDCISAKKKEVWKTEEKFLKDILMWLQSSNFEDPDTISLIHEIEKIFEEDIHFEQNVSDCLKEISNNFEYICMRETQLINEGNILKNDLKKYAKAREHKGEKHEDTEVLREKVISSQKSFDVTKRHYKHAISITTRQLFMNLAFEYYENCSDMKDISRKYLQESLSTLQTIDTLSFSEELEKIRKRRFDKFWAKTNPDPTNNIQKFVNMRTGVAGFNDSLMNHLYGKLSFGVAPVEEELQNSQPEHTDVPENVWNEVLSDYNSMDGNPITSNKFLSAKELEPDQLVELLAQEKEEKEAKNISSSTAEVPSISQPEIKKENLESNDSLILRSTKRNVNVNAASLRNLSIKKTQVKPESASEESKVLAAALNDAKQNLDENVWRTPI
SIO_010081: YHR184W
subclass of: SO_0000673
so part of: YHR184W
location: 472744..474459
location: region:472744-474459:1
so has part: feature:472744-474459:1:exon

NP_012054.1
type: Protein
SIO_000068: ncbiprotein

S000001227
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472744-474459:1:exon

YHR185C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ADY1
gene: PFS1
locus tag: YHR185C
gene synonym: ADY1
so part of: sequence
location: complement(<474627..>475340)
location: region:474627-475340:-1
so has part: feature:474627-475340:-1:exon
subclass of: SO_0000010

856591
type: Gene
SIO_000068: ncbigene

position:474627:-1
position: 474627
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475340:-1
position: 475340
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:474627-475340:-1:exon

YHR185C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ADY1
gene: PFS1
locus tag: YHR185C
gene synonym: ADY1
product: Pfs1p
transcript id: NM_001179316.3
SIO_010081: YHR185C
subclass of: SO_0000673
so part of: YHR185C
location: complement(<474627..>475340)
location: region:474627-475340:-1
so has part: feature:474627-475340:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:474627-475340:-1:exon

YHR185C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ADY1
gene: PFS1
locus tag: YHR185C
gene synonym: ADY1
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11553705]
note: Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
codon start: 1
product: Pfs1p
translation: MNQGYTQLSAPELKETKTSKLNKMNNFRSSPIAEIINKIPPDCGKIQNTTFPEFNPALRRRQHEQWPAYEKPIRVTDSMSPQLSSINCLPNLYPHGTLPLPNPYLSYLNHIEKVNCQDVKFSNWSVLHNSNNGFEIPTYFSPRTTQNMPCSEKVESWLERLPIFVGFDGYLFTNCFDYEYMLDWEETEFTFEKTSCMETDYSKALTDTDIIYIQEKKIEALIRNQYLKEYEFSQKDF
SIO_010081: YHR185C
subclass of: SO_0000673
so part of: YHR185C
location: complement(474627..475340)
location: region:474627-475340:-1
so has part: feature:474627-475340:-1:exon

NP_012055.3
type: Protein
SIO_000068: ncbiprotein

S000001228
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:474627-475340:-1:exon

YNCH0016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCH0016C
so part of: sequence
location: complement(475706..475778)
location: region:475706-475778:-1
so has part: feature:475706-475778:-1:exon
subclass of: SO_0000663

856592
type: Gene
SIO_000068: ncbigene

position:475706:-1
position: 475706
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:475778:-1
position: 475778
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475706-475778:-1:exon

YNCH0016C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCH0016C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCH0016C
subclass of: SO_0000673
so part of: YNCH0016C
location: complement(475706..475778)
location: region:475706-475778:-1
so has part: feature:475706-475778:-1:exon

S000006768
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475706-475778:-1:exon

YHR186C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LAS24
gene: KOG1
locus tag: YHR186C
gene synonym: LAS24
so part of: sequence
location: complement(<475999..>480672)
location: region:475999-480672:-1
so has part: feature:475999-480672:-1:exon
subclass of: SO_0000010

856593
type: Gene
SIO_000068: ncbigene

position:475999:-1
position: 475999
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:480672:-1
position: 480672
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475999-480672:-1:exon

YHR186C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LAS24
gene: KOG1
locus tag: YHR186C
gene synonym: LAS24
product: ubiquitin-binding TORC1 subunit KOG1
transcript id: NM_001179317.1
SIO_010081: YHR186C
subclass of: SO_0000673
so part of: YHR186C
location: complement(<475999..>480672)
location: region:475999-480672:-1
so has part: feature:475999-480672:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:475999-480672:-1:exon

YHR186C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LAS24
gene: KOG1
locus tag: YHR186C
gene synonym: LAS24
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16394584|PMID:17560372|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16394584]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]
experiment: EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]
note: Ubiquitin-binding protein; centrally regulates metabolic homeostasis and carbon utilization during nutrient limitation by managing Snf1p activity; subunit of TORC1 rapamycin-sensitive complex involved in growth control; central scaffold that holds the different components of TORC1 together; contains four HEAT repeats and seven WD-40 repeats
codon start: 1
product: ubiquitin-binding TORC1 subunit KOG1
translation: MPEIYGPQPLKPLNTVMRHGFEEQYQSDQLLQSLANDFIFYFDDKRHKTNGNPIPEEDKQRDVNRYYQPITDWKIMKDRQKTVSAALLLCLNLGVDPPDVMKTHPCARVEAWVDPLNFQDSKKAIEQIGKNLQAQYETLSLRTRYKQSLDPCVEDVKRFCNSLRRTSKEDRILFHYNGHGVPKPTKSGEIWVFNRGYTQYIPVSLYDLQTWLGAPCIFVYDCNSAENILINFQKFVQKRIKDDEEGNHDVAAPSPTSAYQDCFQLASCTSDELLLMSPELPADLFSCCLTCPIEISIRIFLMQSPLKDSKYKIFFENSTSNQPFGDSKNSFKSKIPNVNIPGMLSDRRTPLGELNWIFTAITDTIAWTSLPRPLFKKLFRHDLMIAALFRNFLLAKRIMPWYNCHPVSDPELPDSITTHPMWKSWDLAMDEVLTKIVIDLKNAPPATALESQMILQQQETLQNGGSSKSNAQDTKAGSIQTQSRFAVANLSTMSLVNNPALQSRKSISLQSSQQQLQQQQQQQQQFTGFFEQNLTAFELWLKYASNVRHPPEQLPIVLQVLLSQVHRIRALVLLSRFLDLGPWAVYLSLSIGIFPYVLKLLQSPAPELKPILVFIWARIMSIDYKNTQSELIKEKGYMYFVTVLVPDWGVNGMSATNGSAMINSGNPLTMTASQNINGPSSRYYERQQGNRTSNLGHNNLPFYHSNDTTDEQKAMAVFVLASFVRNFPLGQKNCFSLELVNKLCFYIDNSEIPLLRQWCVILLGLLFADNPLNRFVCMNTGAVEILLKSLKDPVPEVRTASIFALKHFISGFQDAEVILRLQQEFEEQYQQLHSQLQHLQNQSHLQQQQSQQQQQHLEQQQMKIEKQIRHCQVMQNQLEVIDLRKLKRQEIGNLISILPLINDGSSLVRKELVVYFSHIVSRYSNFFIVVVFNDLLEEIKLLEKSDINTRNTSDKYSVSQGSIFYTVWKSLLILAEDPFLENKELSKQVIDYILLELSAHKELGGPFAVMEKFLLKRSSKAHQTGKFGFNSSQVQFVKSSLRSFSPNERVDNNAFKKEQQQHDPKISHPMRTSLAKLFQSLGFSESNSDSDTQSSNTSMKSHTSKKGPSGLYLLNGNNNIYPTAETPRFRKHTEPLQLPLNSSFLDYSREYFQEPQMKKQEADEPGSVEYNARLWRRNRNETIIQETQGEKKLSIYGNWSKKLISLNNKSQPKLMKFAQFEDQLITADDRSTITVFDWEKGKTLSKFSNGTPFGTKVTDLKLINEDDSALLLTGSSDGVIKIYRDYQDVDTFKIVSAWRGLTDMLLTPRSTGLLTEWLQIRGSLLTTGDVKVIRVWDAHTETVEVDIPAKTSSLITSLTADQLAGNIFVAGFADGSLRVYDRRLDPRDSMIRRWRAGNDKQGVWINNVHLQRGGYRELVSGATNGVVELWDIRSEDPVESFVDQNVTSQYGSQQKPTTMTCMQVHEHAPIIATGTKQIKIWTTSGDLLNSFKNSHNNGVTSTLAATGIPKSLSYSSTSDAFLSSMAFHPHRMMIAATNSHDSIVNIYKCEDERIDYF
SIO_010081: YHR186C
subclass of: SO_0000673
so part of: YHR186C
location: complement(475999..480672)
location: region:475999-480672:-1
so has part: feature:475999-480672:-1:exon

NP_012056.1
type: Protein
SIO_000068: ncbiprotein

S000001229
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475999-480672:-1:exon

YHR187W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ELP5
alternative label: HAP2
alternative label: TOT5
gene: IKI1
locus tag: YHR187W
gene synonym: ELP5; HAP2; TOT5
so part of: sequence
location: <480990..>481919
location: region:480990-481919:1
so has part: feature:480990-481919:1:exon
subclass of: SO_0000010

856594
type: Gene
SIO_000068: ncbigene

position:480990:1
position: 480990
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:481919:1
position: 481919
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:480990-481919:1:exon

YHR187W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ELP5
alternative label: HAP2
alternative label: TOT5
gene: IKI1
locus tag: YHR187W
gene synonym: ELP5; HAP2; TOT5
product: Elongator subunit IKI1
transcript id: NM_001179318.3
SIO_010081: YHR187W
subclass of: SO_0000673
so part of: YHR187W
location: <480990..>481919
location: region:480990-481919:1
so has part: feature:480990-481919:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:480990-481919:1:exon

YHR187W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ELP5
alternative label: HAP2
alternative label: TOT5
gene: IKI1
locus tag: YHR187W
gene synonym: ELP5; HAP2; TOT5
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:22343726]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22343726]
experiment: EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]
experiment: EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:15769872]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:22343726]
note: Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; localizes to cytosol, nucleus and peroxisomes
codon start: 1
product: Elongator subunit IKI1
translation: MASSSHNPVILLKRILSLTESSPFILCLDSIAQTSYKLIQEFVHQSKSKGNEYPIVYISFETVNKPSYCTQFIDATQMDFVHLVKQIISYLPAATATQAKKHMVIIDSLNYISTEYITRFLSEIASPHCTMVATYHKDIKDENRTVIPDWNNNYPDKLTLLQFMATTIVDIDVVLTGTLDTEEVSELLNEFRIPRGLNNDIFQLRLVNKRKSGRSLEYDFIVNSNTHEYELLSTTKQEEESSSNGLETPEMLQGLTTFNLGTSNKQKLAKDQVALPFLEAQSFGQGGAIVYEYEKDDDYDEEDPYEDPF
SIO_010081: YHR187W
subclass of: SO_0000673
so part of: YHR187W
location: 480990..481919
location: region:480990-481919:1
so has part: feature:480990-481919:1:exon

NP_012057.3
type: Protein
SIO_000068: ncbiprotein

S000001230
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:480990-481919:1:exon

YHR188C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPI16
locus tag: YHR188C
so part of: sequence
location: complement(<482005..>483837)
location: region:482005-483837:-1
so has part: feature:482005-483837:-1:exon
subclass of: SO_0000010

856595
type: Gene
SIO_000068: ncbigene

position:482005:-1
position: 482005
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483837:-1
position: 483837
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482005-483837:-1:exon

YHR188C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPI16
locus tag: YHR188C
product: GPI-anchor transamidase subunit GPI16
transcript id: NM_001179319.1
SIO_010081: YHR188C
subclass of: SO_0000673
so part of: YHR188C
location: complement(<482005..>483837)
location: region:482005-483837:-1
so has part: feature:482005-483837:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482005-483837:-1:exon

YHR188C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPI16
locus tag: YHR188C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11598210]
experiment: EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:11598210]
experiment: EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:11598210]
note: Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog
codon start: 1
product: GPI-anchor transamidase subunit GPI16
translation: MILTLAYFMLGTLLLGVFAEDTVSQIGINDSLWYPYDEALVLKPLPNNDLLLSFAFQLQSEPFDPAVSSMSYDAYEHYTTFPRAIPPLLESTATRQFHLRFTRGFWDALSWGQLPHAGKEAGASGVELWSQVQAMDQEQAFHNWKKLSNSLSGLFCSSLNFIDESRTTFPRRSYASDIGAPLFNSTEKLYLMRASLPNEPICTENLTPFIKLLPTRGKSGLTSLLDGHKLFDSLWNSISLDIATICSEDEDALCHYEMDARIEMVTHVPSALARGERPIPKPLDGNTLRCDTDKPFDSYQCFPLPEPSQTHFKLSQLFARPINNGNLFANRPTRICAEVDRSTWTAFLSVDDTIFSTHDNCFDLSNDQNEGGSGYDFILESTDTTKVTPIVPVPIHVSRSLTGNGQDRGGMRIVFHNDNDTPVKLIYFESLPWFMRVYLSSLQITSTTSPQLQENDIILDKYYLQAADRKRPGHLEFTMLIPANTDIVMTYQFDKALLQFAEYPPDANHGFEIDAAVITVLSLESSSSLYEMRTSTLLLSLSTPDFSMPYNVIILTSTIMGLIFGMLYNLMVKRMVTVEEADKITLQSGLKYKLLKLKEKFLGKKKTKTD
SIO_010081: YHR188C
subclass of: SO_0000673
so part of: YHR188C
location: complement(482005..483837)
location: region:482005-483837:-1
so has part: feature:482005-483837:-1:exon

NP_012058.1
type: Protein
SIO_000068: ncbiprotein

S000001231
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482005-483837:-1:exon

YHR189W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTH1
locus tag: YHR189W
so part of: sequence
location: <484028..>484600
location: region:484028-484600:1
so has part: feature:484028-484600:1:exon
subclass of: SO_0000010

856596
type: Gene
SIO_000068: ncbigene

position:484028:1
position: 484028
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:484600:1
position: 484600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484028-484600:1:exon

YHR189W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTH1
locus tag: YHR189W
product: aminoacyl-tRNA hydrolase
transcript id: NM_001179320.3
SIO_010081: YHR189W
subclass of: SO_0000673
so part of: YHR189W
location: <484028..>484600
location: region:484028-484600:1
so has part: feature:484028-484600:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:484028-484600:1:exon

YHR189W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTH1
locus tag: YHR189W
EC number: 3.1.1.29
experiment: EXISTENCE:direct assay:GO:0004045 aminoacyl-tRNA hydrolase activity [PMID:12799450]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:14576278]
experiment: EXISTENCE:genetic interaction:GO:0004045 aminoacyl-tRNA hydrolase activity [PMID:12475929]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12799450]
note: One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2
codon start: 1
product: aminoacyl-tRNA hydrolase
translation: MSGKWRLVLTGIGNPEPQYAGTRHNVGLYMLELLRKRLGLQGRTYSPVPNTGGKVHYIEDEHCTILRSDGQYMNLSGEQVCKVWARYAKYQARHVVIHDELSVACGKVQLRAPSTSIRGHNGLRSLLKCSGGRVPFAKLAIGIGREPGSRSRDPASVSRWVLGALTPQELQTLLTQSEPAAWRALTQYIS
SIO_010081: YHR189W
subclass of: SO_0000673
so part of: YHR189W
location: 484028..484600
location: region:484028-484600:1
so has part: feature:484028-484600:1:exon

NP_012059.3
type: Protein
SIO_000068: ncbiprotein

S000001232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:484028-484600:1:exon

YHR190W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG9
locus tag: YHR190W
so part of: sequence
location: <484845..>486179
location: region:484845-486179:1
so has part: feature:484845-486179:1:exon
subclass of: SO_0000010

856597
type: Gene
SIO_000068: ncbigene

position:484845:1
position: 484845
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486179:1
position: 486179
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484845-486179:1:exon

YHR190W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG9
locus tag: YHR190W
product: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
transcript id: NM_001179321.1
SIO_010081: YHR190W
subclass of: SO_0000673
so part of: YHR190W
location: <484845..>486179
location: region:484845-486179:1
so has part: feature:484845-486179:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:484845-486179:1:exon

YHR190W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG9
locus tag: YHR190W
EC number: 2.5.1.21
experiment: EXISTENCE:direct assay:GO:0004310 farnesyl-diphosphate farnesyltransferase activity [PMID:8157649|PMID:8323279]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:1807826]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8323279]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:350878]
experiment: EXISTENCE:direct assay:GO:0051996 squalene synthase activity [PMID:8157649|PMID:8323279]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1807826|PMID:200835]
note: Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
codon start: 1
product: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
translation: MGKLLQLALHPVEMKAALKLKFCRTPLFSIYDQSTSPYLLHCFELLNLTSRSFAAVIRELHPELRNCVTLFYLILRALDTIEDDMSIEHDLKIDLLRHFHEKLLLTKWSFDGNAPDVKDRAVLTDFESILIEFHKLKPEYQEVIKEITEKMGNGMADYILDENYNLNGLQTVHDYDVYCHYVAGLVGDGLTRLIVIAKFANESLYSNEQLYESMGLFLQKTNIIRDYNEDLVDGRSFWPKEIWSQYAPQLKDFMKPENEQLGLDCINHLVLNALSHVIDVLTYLAGIHEQSTFQFCAIPQVMAIATLALVFNNREVLHGNVKIRKGTTCYLILKSRTLRGCVEIFDYYLRDIKSKLAVQDPNFLKLNIQISKIEQFMEEMYQDKLPPNVKPNETPIFLKVKERSRYDDELVPTQQEEEYKFNMVLSIILSVLLGFYYIYTLHRA
SIO_010081: YHR190W
subclass of: SO_0000673
so part of: YHR190W
location: 484845..486179
location: region:484845-486179:1
so has part: feature:484845-486179:1:exon

NP_012060.1
type: Protein
SIO_000068: ncbiprotein

S000001233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:484845-486179:1:exon

YHR191C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CTF8
locus tag: YHR191C
so part of: sequence
location: complement(<486230..>486631)
location: region:486230-486631:-1
so has part: feature:486230-486631:-1:exon
subclass of: SO_0000010

856598
type: Gene
SIO_000068: ncbigene

position:486230:-1
position: 486230
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:486631:-1
position: 486631
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486230-486631:-1:exon

YHR191C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CTF8
locus tag: YHR191C
product: Ctf8p
transcript id: NM_001179322.3
SIO_010081: YHR191C
subclass of: SO_0000673
so part of: YHR191C
location: complement(<486230..>486631)
location: region:486230-486631:-1
so has part: feature:486230-486631:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486230-486631:-1:exon

YHR191C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CTF8
locus tag: YHR191C
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843|PMID:17483413]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16525505]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:21347277]
experiment: EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]
note: Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion
codon start: 1
product: Ctf8p
translation: MPSVDIDASQWQKLTQSREKQTTVITPLGMMMLEIQGELELPKDFASLARRDSPNEGRFSEQDGETLIRFGSLQIDGERATLFVGKKQRLLGKVTKLDVPMGIMHFNSKDNKVELVDVMKYKVIFKDRPLPIM
SIO_010081: YHR191C
subclass of: SO_0000673
so part of: YHR191C
location: complement(486230..486631)
location: region:486230-486631:-1
so has part: feature:486230-486631:-1:exon

NP_012061.3
type: Protein
SIO_000068: ncbiprotein

S000001234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486230-486631:-1:exon

YHR192W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LNP1
locus tag: YHR192W
so part of: sequence
location: <486826..>487662
location: region:486826-487662:1
so has part: feature:486826-487662:1:exon
subclass of: SO_0000010

856599
type: Gene
SIO_000068: ncbigene

position:486826:1
position: 486826
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:487662:1
position: 487662
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:486826-487662:1:exon

YHR192W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LNP1
locus tag: YHR192W
product: Lnp1p
transcript id: NM_001179323.1
SIO_010081: YHR192W
subclass of: SO_0000673
so part of: YHR192W
location: <486826..>487662
location: region:486826-487662:1
so has part: feature:486826-487662:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:486826-487662:1:exon

YHR192W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LNP1
locus tag: YHR192W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:22729086]
experiment: EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:29915089]
experiment: EXISTENCE:mutant phenotype:GO:0071786 endoplasmic reticulum tubular network organization [PMID:22729086]
note: Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS
codon start: 1
product: Lnp1p
translation: MFSALGKWVRGSRNDKDFVTKYTADLSQITSQIHQLDVALKKSQSILSQWQSNLTFYGIALTVLALSYTYWEYHGYRPYLVVTALLCIGSLILFKWALTKLYAFYNNNRLRKLAKLRAIHQKKLEKLKEETHYNATSSIIQRFSSGEDQNDDAMVLLDDELNAKYQELNNLKTELEKFKKESHVKGLKKEDSDAWFDKIISVLAGGNELDSTSSLSPFKKIICPQCHWKSNCYRLASKPIIFICPHCNHKIDEVKEREDAIEAKQPAQPSQSEKEKTK
SIO_010081: YHR192W
subclass of: SO_0000673
so part of: YHR192W
location: 486826..487662
location: region:486826-487662:1
so has part: feature:486826-487662:1:exon

NP_012062.1
type: Protein
SIO_000068: ncbiprotein

S000001235
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:486826-487662:1:exon

YHR193C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EGD2
locus tag: YHR193C
so part of: sequence
location: complement(<487712..>488236)
location: region:487712-488236:-1
so has part: feature:487712-488236:-1:exon
subclass of: SO_0000010

856600
type: Gene
SIO_000068: ncbigene

position:487712:-1
position: 487712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:488236:-1
position: 488236
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487712-488236:-1:exon

YHR193C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EGD2
locus tag: YHR193C
product: Egd2p
transcript id: NM_001179324.3
SIO_010081: YHR193C
subclass of: SO_0000673
so part of: YHR193C
location: complement(<487712..>488236)
location: region:487712-488236:-1
so has part: feature:487712-488236:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:487712-488236:-1:exon

YHR193C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EGD2
locus tag: YHR193C
experiment: EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:10219998]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:16343487]
experiment: EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:16343487]
experiment: EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16343487]
experiment: EXISTENCE:genetic interaction:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:10518932]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9482879]
note: Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes
codon start: 1
product: Egd2p
translation: MSAIPENANVTVLNKNEKKARELIGKLGLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGNYVVFGEAKVDNFTQKLAAAQQQAQASGIMPSNEDVATKSPEDIQADMQAAAEGSVNAAAEEDDEEGEVDAGDLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK
SIO_010081: YHR193C
subclass of: SO_0000673
so part of: YHR193C
location: complement(487712..488236)
location: region:487712-488236:-1
so has part: feature:487712-488236:-1:exon

NP_012063.3
type: Protein
SIO_000068: ncbiprotein

S000001236
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:487712-488236:-1:exon

YHR194W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDM31
locus tag: YHR194W
so part of: sequence
location: <488657..>490396
location: region:488657-490396:1
so has part: feature:488657-490396:1:exon
subclass of: SO_0000010

856601
type: Gene
SIO_000068: ncbigene

position:488657:1
position: 488657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490396:1
position: 490396
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488657-490396:1:exon

YHR194W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDM31
locus tag: YHR194W
product: Mdm31p
transcript id: NM_001179325.1
SIO_010081: YHR194W
subclass of: SO_0000673
so part of: YHR194W
location: <488657..>490396
location: region:488657-490396:1
so has part: feature:488657-490396:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488657-490396:1:exon

YHR194W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDM31
locus tag: YHR194W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15631992]
experiment: EXISTENCE:genetic interaction:GO:1900208 regulation of cardiolipin metabolic process [PMID:22403410]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:15631992]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:16020778]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266|PMID:16020778]
note: Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
codon start: 1
product: Mdm31p
translation: MSLFTRPFLRSPRQFSVARYVYWARSPALRSNLRIPSIAAASLRAYSNESKTGRDAPPDKKSKKLSNLKYITERDSLLVQTNNIFTKLKINIRWFLKKSTRPFNSDDISAFISWILVSNIFIFIFWTTTFVSLILYLINTVFAQEYLASKIGKFITKNESLSIVFESAIVPDWSSGKISFQKVFVSRRPKVSRGFTKGSQQDALQRAKLALSERILVNQQDFDNGNYTQFDLTIDQVDISLNFRKWINGKGILDEVTINGLRGVIDRTHVVWKKDDDPKNYLNVYQPGDFEISKFTMNDVLCTLYQPNGFRPFQVSIFNCDLPQLRKHWLFYDILNANNINGTYDNSMFTIHKKFRTDDQHQDPTLLWKQMTRFRVDNLDIDHLNAGIEGPFGWINEGRVNMIGDVLLPDDDAASDSLQLTEILTEIGDRLIKKAKRYTSSLPLVGPGFSPAVDEIDPNDYFIMDFSLRLYNVKAEVPLFTSGLTYINSALIRPIVGYINSHRTYIPIKCRIVKKKSDFEGSWTIYDSYLMRDLSAEAYDAFADYVADDEKRTLRLRRVGFWSLQLILQVILMSLGAIA
SIO_010081: YHR194W
subclass of: SO_0000673
so part of: YHR194W
location: 488657..490396
location: region:488657-490396:1
so has part: feature:488657-490396:1:exon

NP_012064.1
type: Protein
SIO_000068: ncbiprotein

S000001237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488657-490396:1:exon

YHR195W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VAB36
gene: NVJ1
locus tag: YHR195W
gene synonym: VAB36
so part of: sequence
location: <490747..>491712
location: region:490747-491712:1
so has part: feature:490747-491712:1:exon
subclass of: SO_0000010

856602
type: Gene
SIO_000068: ncbigene

position:490747:1
position: 490747
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:491712:1
position: 491712
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490747-491712:1:exon

YHR195W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VAB36
gene: NVJ1
locus tag: YHR195W
gene synonym: VAB36
product: Nvj1p
transcript id: NM_001179326.3
SIO_010081: YHR195W
subclass of: SO_0000673
so part of: YHR195W
location: <490747..>491712
location: region:490747-491712:1
so has part: feature:490747-491712:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490747-491712:1:exon

YHR195W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VAB36
gene: NVJ1
locus tag: YHR195W
gene synonym: VAB36
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:28533415]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:16912077]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:12529432]
experiment: EXISTENCE:mutant phenotype:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]
note: Nuclear envelope protein; anchored to nuclear inner membrane, interacts with vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN); targeted to vacuole via AP-3 pathway
codon start: 1
product: Nvj1p
translation: MTRPPLVRGIFSLGLSVAVLKGVEKTVRKHLERQGWIEPQKVDYELIFTIDRLKNLVDNKREALTAEQPDAGELSWRKVFNFISRQSSELDTRIYVLILLLSFLLPIAWTVLDGDRETTLEDKDNDCNVDLIENERRLKHYNDGERAVLQFGKNRSEPIILSYKDMNVLEGEHEFTSKEEHSNSHLTSKSENALNQVGSEDLLGCHLEKQLEEDKNEPNGEADGEDDNNREKDCSSSSEVESQSKCRKESTAEPDSLSRDTRTTSSLKSSTSFPISFKGSIDLKSLNQPSSLLHIQVSPTKSSNLDAQVNTEQAYSQPFRY
SIO_010081: YHR195W
subclass of: SO_0000673
so part of: YHR195W
location: 490747..491712
location: region:490747-491712:1
so has part: feature:490747-491712:1:exon

NP_012065.3
type: Protein
SIO_000068: ncbiprotein

S000001238
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490747-491712:1:exon

YHR196W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTP9
locus tag: YHR196W
so part of: sequence
location: <491931..>493658
location: region:491931-493658:1
so has part: feature:491931-493658:1:exon
subclass of: SO_0000010

856603
type: Gene
SIO_000068: ncbigene

position:491931:1
position: 491931
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:493658:1
position: 493658
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491931-493658:1:exon

YHR196W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTP9
locus tag: YHR196W
product: Utp9p
transcript id: NM_001179327.1
SIO_010081: YHR196W
subclass of: SO_0000673
so part of: YHR196W
location: <491931..>493658
location: region:491931-493658:1
so has part: feature:491931-493658:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491931-493658:1:exon

YHR196W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTP9
locus tag: YHR196W
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19812255]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309|PMID:12150911|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]
experiment: EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]
experiment: EXISTENCE:mutant phenotype:GO:0071528 tRNA re-export from nucleus [PMID:19812255]
note: Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
codon start: 1
product: Utp9p
translation: MGSSLDLVASFSHDSTRFAFQASVAQKNNVDIYPLNETKDYVVNSSLVSHIDYETNDMKVSDVIFFGWCSDLIDTQSSNIKRKLDEDEGTGESSEQRCENFFVNGFPDGRIVVYSSNGKDIVNIIKNKKEILGADTDESDIWILDSDKVVKKLQYNNSKPLKTFTLVDGKDDEIVHFQILHQNGTLLVCIITKQMVYIVDPSKRRPSTKYSFEISDAVACEFSSDGKYLLIANNEELIAYDLKEDSKLIQSWPVQVKTLKTLDDLIMALTTDGKINNYKIGEADKVCSIVVNEDLEIIDFTPINSKQQVLISWLNVNEPNFESISLKEIETQGYITINKNEKNNADEADQKKLEEKEEEAQPEVQHEKKETETKINKKVSKSDQVEIANILSSHLEANSTEILDDLMSGSWTEPEIKKFILTKINTVDHLSKIFLTISKSITQNPWNEENLLPLWLKWLLTLKSGELNSIKDKHTKKNCKHLKSALRSSEEILPVLLGIQGRLEMLRRQAKLREDLAQLSMQEGEDDEIEVIEHSNVISNPLQDQASPVEKLEPDSIVYANGESDEFVDASEYKD
SIO_010081: YHR196W
subclass of: SO_0000673
so part of: YHR196W
location: 491931..493658
location: region:491931-493658:1
so has part: feature:491931-493658:1:exon

NP_012066.1
type: Protein
SIO_000068: ncbiprotein

S000001239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491931-493658:1:exon

YHR197W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IPI2
gene: RIX1
locus tag: YHR197W
gene synonym: IPI2
so part of: sequence
location: <493896..>496187
location: region:493896-496187:1
so has part: feature:493896-496187:1:exon
subclass of: SO_0000010

856604
type: Gene
SIO_000068: ncbigene

position:493896:1
position: 493896
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:496187:1
position: 496187
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:493896-496187:1:exon

YHR197W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IPI2
gene: RIX1
locus tag: YHR197W
gene synonym: IPI2
product: Rix1p
transcript id: NM_001179328.4
SIO_010081: YHR197W
subclass of: SO_0000673
so part of: YHR197W
location: <493896..>496187
location: region:493896-496187:1
so has part: feature:493896-496187:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:493896-496187:1:exon

YHR197W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IPI2
gene: RIX1
locus tag: YHR197W
gene synonym: IPI2
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12374754|PMID:15528184]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0097344 Rix1 complex [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]
experiment: EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]
experiment: EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]
note: Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene
codon start: 1
product: Rix1p
translation: MSEEFIAVSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGGQLLAAIYSRLEQKTGFYSSVISSSHGKQLFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPVLQRILKRNTTTFKPFTNKFRTVLINLIISDYASLGTKTQRLVCENFAYLHLLKIQVSDTSDDETQAHHKIYADSNWRTGLMSILSQFKPIIQLCGEILDFEQDNELYKLIKSLPVIDESNNKEEFLPSLKLDFNAPLTLWEIPQRLSLLADMLVAFISLPTPFPIRVPLGGINSLCEVLLGVSNKYLPLKKELRHDNELNGVINTILPQIQFQGIRLWEIMVSKYGKCGLSFFEGILSSIELFIPLKKKSNNEIDFNVVGSLKFEFATVFRLVNMILSHLGHQLNIISVISQLIEVALFLSHDKTLIDSLFKNRKSIMKQQTKTKQSKRSKSAEGAFSDIYTHPELFVCKNSMNWFNEINDFFITALNNWILPSTPHIQILKYSITQSLRLKERFGYIPESFVNLLRCEVLHPGSERVSILPIAISLLKNINDDMFELLCHPKVPVGMVYQLHKPLDLGEDGEVRDDINKKEVETNESSSNANTGLETLKALENLENVTIPEPKHEVPKVVDDTAIFKKRSVEEVIERESTSSHKKVKFVEETTVDNGEELIVKKAVSQTKEEEKPMEDSEDEEQEEFEIPAIELSDDEEEEEEEE
SIO_010081: YHR197W
subclass of: SO_0000673
so part of: YHR197W
location: 493896..496187
location: region:493896-496187:1
so has part: feature:493896-496187:1:exon

NP_012067.4
type: Protein
SIO_000068: ncbiprotein

S000001240
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:493896-496187:1:exon

YHR198C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP22
gene: AIM18
locus tag: YHR198C
gene synonym: FMP22
so part of: sequence
location: complement(<496315..>497280)
location: region:496315-497280:-1
so has part: feature:496315-497280:-1:exon
subclass of: SO_0000010

856605
type: Gene
SIO_000068: ncbigene

position:496315:-1
position: 496315
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:497280:-1
position: 497280
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496315-497280:-1:exon

YHR198C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP22
gene: AIM18
locus tag: YHR198C
gene synonym: FMP22
product: Aim18p
transcript id: NM_001179329.1
SIO_010081: YHR198C
subclass of: SO_0000673
so part of: YHR198C
location: complement(<496315..>497280)
location: region:496315-497280:-1
so has part: feature:496315-497280:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:496315-497280:-1:exon

YHR198C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP22
gene: AIM18
locus tag: YHR198C
gene synonym: FMP22
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
codon start: 1
product: Aim18p
translation: MDRGRCANMLKSLQRTLAKCQKSPSTNHWQCFKRNFTSIRATKYPGRSNSTFHYWPWFAASTLLATSLYYRDRPVQNDDKTDAFPSHTESIQVDSSVSDFPLTITALNFPVSTTFKLLGYGQRHVTFLRFKVYALGLYLAENDENLVSDTLNETYLHKYFLDVDDSKTPKENLARLLKRDDSKSVMMIDDLLDSGMRMLAKITPVRNTDFKHLKEGLVKTISKHPDVANNKDTLAKGLSELNDAFSRKGSVRKNDDLIIELLANGALQFSYHDSKNNEFEVMGVVNNQLVGKFLFSQYLCGEKSPSPQAKKTAIDKLITLL
SIO_010081: YHR198C
subclass of: SO_0000673
so part of: YHR198C
location: complement(496315..497280)
location: region:496315-497280:-1
so has part: feature:496315-497280:-1:exon

NP_012068.1
type: Protein
SIO_000068: ncbiprotein

S000001241
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:496315-497280:-1:exon

YHR199C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP34
gene: AIM46
locus tag: YHR199C
gene synonym: FMP34
so part of: sequence
location: complement(<497490..>498422)
location: region:497490-498422:-1
so has part: feature:497490-498422:-1:exon
subclass of: SO_0000010

856606
type: Gene
SIO_000068: ncbigene

position:497490:-1
position: 497490
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498422:-1
position: 498422
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497490-498422:-1:exon

YHR199C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP34
gene: AIM46
locus tag: YHR199C
gene synonym: FMP34
product: Aim46p
transcript id: NM_001179330.3
SIO_010081: YHR199C
subclass of: SO_0000673
so part of: YHR199C
location: complement(<497490..>498422)
location: region:497490-498422:-1
so has part: feature:497490-498422:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:497490-498422:-1:exon

YHR199C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP34
gene: AIM46
locus tag: YHR199C
gene synonym: FMP34
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
codon start: 1
product: Aim46p
translation: MRLISKVLVKTNCLEVGMRRAPQWYSHYSTTAGNARVNKKGSKVVPVLTGLALASIFAKKWYDDSQIKKADATSVAVDASISAFPKKMGPPQWPFSTQYELIGKGVRCVSSITFKAYGLGIYVAAEDKHLVSEVLDSKFLSQAFIDTAAPPSPENSHQDNLRAALNDPAKAPILINNLLDSGIRLMSKNTPIKAGSFKLLMDGTKKSVLKNPDSQSQDKDRLEAGFQELHDCFRSVKGLVARDDDFFIELNKDCSMNLSYYARKKDEFVILGTVKEPLIGKLLFAHYLAAVDPPSPEARKEVIDALVSLS
SIO_010081: YHR199C
subclass of: SO_0000673
so part of: YHR199C
location: complement(497490..498422)
location: region:497490-498422:-1
so has part: feature:497490-498422:-1:exon

NP_012069.3
type: Protein
SIO_000068: ncbiprotein

S000001242
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:497490-498422:-1:exon

YHR199C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NBL1
locus tag: YHR199C-A
so part of: sequence
location: complement(<498571..>498859)
location: region:498571-498859:-1
so has part: feature:498571-498859:-1:exon
subclass of: SO_0000010

2746858
type: Gene
SIO_000068: ncbigene

position:498571:-1
position: 498571
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498859:-1
position: 498859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498571-498859:-1:exon

YHR199C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NBL1
locus tag: YHR199C-A
product: Nbl1p
transcript id: NM_001184671.1
SIO_010081: YHR199C-A
subclass of: SO_0000673
so part of: YHR199C-A
location: complement(join(<498571..498719,498787..>498859))
location: region:498571-498859:-1
so has part: feature:498787-498859:-1:exon
so has part: feature:498571-498719:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:498787-498859:-1:exon

position:498787:-1
position: 498787
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:498571-498719:-1:exon

position:498719:-1
position: 498719
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR199C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NBL1
locus tag: YHR199C-A
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:19158380]
experiment: EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:19158380]
note: Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p
codon start: 1
product: Nbl1p
translation: MIPALTPEERQKLRSAILHRMQLELETTEKLIENIKEETLKKLNLLQQPDATSAPQSKELIREVLEQEGRRIE
SIO_010081: YHR199C-A
subclass of: SO_0000673
so part of: YHR199C-A
location: complement(join(498571..498719,498787..498859))
location: region:498571-498859:-1
so has part: feature:498787-498859:-1:exon
so has part: feature:498571-498719:-1:exon

NP_976247.1
type: Protein
SIO_000068: ncbiprotein

S000029704
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:498787-498859:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:498571-498719:-1:exon

YHR200W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MCB1
alternative label: SUN1
gene: RPN10
locus tag: YHR200W
gene synonym: MCB1; SUN1
so part of: sequence
location: <499079..>499885
location: region:499079-499885:1
so has part: feature:499079-499885:1:exon
subclass of: SO_0000010

856607
type: Gene
SIO_000068: ncbigene

position:499079:1
position: 499079
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499885:1
position: 499885
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499079-499885:1:exon

YHR200W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MCB1
alternative label: SUN1
gene: RPN10
locus tag: YHR200W
gene synonym: MCB1; SUN1
product: proteasome regulatory particle base subunit RPN10
transcript id: NM_001179331.3
SIO_010081: YHR200W
subclass of: SO_0000673
so part of: YHR200W
location: <499079..>499885
location: region:499079-499885:1
so has part: feature:499079-499885:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499079-499885:1:exon

YHR200W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MCB1
alternative label: SUN1
gene: RPN10
locus tag: YHR200W
gene synonym: MCB1; SUN1
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:8887631]
experiment: EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:20941496]
experiment: EXISTENCE:mutant phenotype:GO:0000502 proteasome complex [PMID:15242647]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15242647]
note: Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein
codon start: 1
product: proteasome regulatory particle base subunit RPN10
translation: MVLEATVLVIDNSEYSRNGDFPRTRFEAQIDSVEFIFQAKRNSNPENTVGLISGAGANPRVLSTFTAEFGKILAGLHDTQIEGKLHMATALQIAQLTLKHRQNKVQHQRIVAFVCSPISDSRDELIRLAKTLKKNNVAVDIINFGEIEQNTELLDEFIAAVNNPQEETSHLLTVTPGPRLLYENIASSPIILEEGSSGMGAFGGSGGDSDANGTFMDFGVDPSMDPELAMALRLSMEEEQQRQERLRQQQQQQDQPEQSEQPEQHQDK
SIO_010081: YHR200W
subclass of: SO_0000673
so part of: YHR200W
location: 499079..499885
location: region:499079-499885:1
so has part: feature:499079-499885:1:exon

NP_012070.3
type: Protein
SIO_000068: ncbiprotein

S000001243
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499079-499885:1:exon

YHR201C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PPX1
locus tag: YHR201C
so part of: sequence
location: complement(<499950..>501143)
location: region:499950-501143:-1
so has part: feature:499950-501143:-1:exon
subclass of: SO_0000010

856608
type: Gene
SIO_000068: ncbigene

position:499950:-1
position: 499950
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:501143:-1
position: 501143
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499950-501143:-1:exon

YHR201C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PPX1
locus tag: YHR201C
product: exopolyphosphatase
transcript id: NM_001179332.1
SIO_010081: YHR201C
subclass of: SO_0000673
so part of: YHR201C
location: complement(<499950..>501143)
location: region:499950-501143:-1
so has part: feature:499950-501143:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499950-501143:-1:exon

YHR201C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PPX1
locus tag: YHR201C
EC number: 3.6.1.11
experiment: EXISTENCE:direct assay:GO:0004309 exopolyphosphatase activity [PMID:17215253|PMID:7860598|PMID:31175919]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7860598]
experiment: EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:8157625]
experiment: EXISTENCE:mutant phenotype:GO:0004309 exopolyphosphatase activity [PMID:7860598]
experiment: EXISTENCE:mutant phenotype:GO:0006798 polyphosphate catabolic process [PMID:7860598]
note: Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
codon start: 1
product: exopolyphosphatase
translation: MSPLRKTVPEFLAHLKSLPISKIASNDVLTICVGNESADMDSIASAITYSYCQYIYNEGTYSEEKKKGSFIVPIIDIPREDLSLRRDVMYVLEKLKIKEEELFFIEDLKSLKQNVSQGTELNSYLVDNNDTPKNLKNYIDNVVGIIDHHFDLQKHLDAEPRIVKVSGSCSSLVFNYWYEKLQGDREVVMNIAPLLMGAILIDTSNMRRKVEESDKLAIERCQAVLSGAVNEVSAQGLEDSSEFYKEIKSRKNDIKGFSVSDILKKDYKQFNFQGKGHKGLEIGLSSIVKRMSWLFNEHGGEADFVNQCRRFQAERGLDVLVLLTSWRKAGDSHRELVILGDSNVVRELIERVSDKLQLQLFGGNLDGGVAMFKQLNVEATRKQVVPYLEEAYSNLEE
SIO_010081: YHR201C
subclass of: SO_0000673
so part of: YHR201C
location: complement(499950..501143)
location: region:499950-501143:-1
so has part: feature:499950-501143:-1:exon

NP_012071.1
type: Protein
SIO_000068: ncbiprotein

S000001244
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499950-501143:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS822; Autonomously Replicating Sequence
so part of: sequence
location: 501756..501996
location: region:501756-501996:1
so has part: feature:501756-501996:1:region

S000118362
type: SGD
SIO_000068: sgd

position:501756:1
position: 501756
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:501996:1
position: 501996
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:501756-501996:1:region

YHR202W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMN1
locus tag: YHR202W
so part of: sequence
location: <502388..>504196
location: region:502388-504196:1
so has part: feature:502388-504196:1:exon
subclass of: SO_0000010

856609
type: Gene
SIO_000068: ncbigene

position:502388:1
position: 502388
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:504196:1
position: 504196
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:502388-504196:1:exon

YHR202W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMN1
locus tag: YHR202W
product: Smn1p
transcript id: NM_001179333.3
SIO_010081: YHR202W
subclass of: SO_0000673
so part of: YHR202W
location: <502388..>504196
location: region:502388-504196:1
so has part: feature:502388-504196:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:502388-504196:1:exon

YHR202W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMN1
locus tag: YHR202W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:35123996]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11935221]
experiment: EXISTENCE:mutant phenotype:GO:0019677 NAD catabolic process [PMID:35123996]
note: Putative AMP hydrolase; secreted protein proposed to function as an adenosine monophosphatase in NAD+ degradation, via nucleoside salvage pathway that converts NAD+ to AMP and adenosine; overexpression results in adenosine accumulation and reduced levels of NAD+, deletion results in increased NAD+ and NADH; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; similar to human NT5E/CD73 gene involved in cancer progression
codon start: 1
product: Smn1p
translation: MILKLVHCLVALTGLIFAKPYQQQQAVLAPSQDVPLRDIHIGDINFIHTTDTHGWLGSHLSQNDYDADWGDFVAFVDILREKILRQSRDVIVIDTGDKRDGNGLSDATWPPGLRSSEIFNMMDYDLLTLGNHELYTAESAILEYRGTSQSSKFKDKYVCSNVEFIEDDGTRVPFGNKYITFETPIMKQRVLALSFLFSFQRANNRAIVTPPLEEITQKSWFQNMVETNREEEIDLIIVFGHLPATDPTEREMHKIHALIRKYYPNTVIQYFGGHTHIRDFVQLDSKSTCLQSGRFAETVGFLSINMTDPVDAESPIFSRRYIDFNKEAFKYHLSKLGHDSNVPVSTKKGKTISRLVNDLRHELNLNEKLGYIPQTYYVSTRPLNSEENLYHLITHKILPNLIPPKNYEPSMSRFILINTGSVRYDLYKGPFTKDTEYIVMPFNNDWRFITVPLVVASRVETYLNKGPVIASLGIPSSSHHKQHFGGFQKCPFINNPNLSEGYTTEDDFGCHGDDTPHNSQREYDIPNVVQCKEVKKVQEEEADPSKMVHVIFYSFMELDILNAVNSIINDLGLRMENLTTNDCSHYGGDSTKKLLRDYFSQF
SIO_010081: YHR202W
subclass of: SO_0000673
so part of: YHR202W
location: 502388..504196
location: region:502388-504196:1
so has part: feature:502388-504196:1:exon

NP_012072.3
type: Protein
SIO_000068: ncbiprotein

S000001245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:502388-504196:1:exon

YHR203C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS4B
locus tag: YHR203C
so part of: sequence
location: complement(<504476..>505530)
location: region:504476-505530:-1
so has part: feature:504476-505530:-1:exon
subclass of: SO_0000010

856610
type: Gene
SIO_000068: ncbigene

position:504476:-1
position: 504476
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:505530:-1
position: 505530
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504476-505530:-1:exon

YHR203C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS4B
locus tag: YHR203C
product: ribosomal 40S subunit protein S4B
transcript id: NM_001179334.1
SIO_010081: YHR203C
subclass of: SO_0000673
so part of: YHR203C
location: complement(join(<504476..505247,505517..>505530))
location: region:504476-505530:-1
so has part: feature:505517-505530:-1:exon
so has part: feature:504476-505247:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:505517-505530:-1:exon

position:505517:-1
position: 505517
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:504476-505247:-1:exon

position:505247:-1
position: 505247
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR203C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS4B
locus tag: YHR203C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S4B
translation: MARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNRLKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRLVYDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPNIKVNDTVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERHDGGFDLVHIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEERDRRRAQQGL
SIO_010081: YHR203C
subclass of: SO_0000673
so part of: YHR203C
location: complement(join(504476..505247,505517..505530))
location: region:504476-505530:-1
so has part: feature:505517-505530:-1:exon
so has part: feature:504476-505247:-1:exon

NP_012073.1
type: Protein
SIO_000068: ncbiprotein

S000001246
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:505517-505530:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:504476-505247:-1:exon

YHR204W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HTM1
gene: MNL1
locus tag: YHR204W
gene synonym: HTM1
so part of: sequence
location: <506319..>508709
location: region:506319-508709:1
so has part: feature:506319-508709:1:exon
subclass of: SO_0000010

856611
type: Gene
SIO_000068: ncbigene

position:506319:1
position: 506319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:508709:1
position: 508709
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506319-508709:1:exon

YHR204W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HTM1
gene: MNL1
locus tag: YHR204W
gene synonym: HTM1
product: alpha-1,2-mannosidase MNL1
transcript id: NM_001179335.3
SIO_010081: YHR204W
subclass of: SO_0000673
so part of: YHR204W
location: <506319..>508709
location: region:506319-508709:1
so has part: feature:506319-508709:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506319-508709:1:exon

YHR204W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HTM1
gene: MNL1
locus tag: YHR204W
gene synonym: HTM1
EC number: 3.2.1.24
experiment: EXISTENCE:direct assay:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:21700223|PMID:27053108]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:19279007]
experiment: EXISTENCE:direct assay:GO:0036508 protein alpha-1,2-demannosylation [PMID:21700223]
experiment: EXISTENCE:direct assay:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:27053108]
experiment: EXISTENCE:genetic interaction:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:21700223]
experiment: EXISTENCE:mutant phenotype:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:19124653]
experiment: EXISTENCE:mutant phenotype:GO:0030246 carbohydrate binding [PMID:11375935]
experiment: EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:11254655|PMID:11375935]
experiment: EXISTENCE:mutant phenotype:GO:1904380 endoplasmic reticulum mannose trimming [PMID:27053108]
experiment: EXISTENCE:mutant phenotype:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:19124653|PMID:27053108]
note: Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant
codon start: 1
product: alpha-1,2-mannosidase MNL1
translation: MVCCLWVLLALLLHLDHVACEDDAYSFTSKELKAYKQEVKELFYFGFDNYLEHGYPYDEVKPISCVPKKRNFEDPTDQGTNDILGNFTITLIDSLTTIAILEDRPQFLKAVRLVERTFPDGNFDIDSTIQVFEITIRVIGSLLSSHLYATDPTKAVYLGDDYDGSLLRLAQNMADRLLPAYLTSTGLPMPRRNIKRKWDVSEFPEFLETENNVAAMASPMFEFTILSYLTGDPKYEKVTRYAFDKTWSLRTGLDLLPMSFHPEKLTPYTPMTGIGASIDSLFEYALKGAILFDDSELMEVWNVAYEALKTNCKNDWFFANVMADTGHLFVPWIDSLSAFFSGLQVLAGDLDDAIANHLMFLKMWNTFGGIPERWNFSPPEFPPLSPLERSGAVALDNILPLEWYPLRPEFFESTYFLYRATKDPFYLNIGVHLLKDLKQRFKSNCGFAGFQNVITGELQDRMETFVLSETLKYLYLLFDEENELHNSASDVIFSTEAHPMWLPQEVRSNYKRNAKFNNSVYSSHLEICQKKDREQAGENTLSQRIVGFAKSIFHKGPPDEEATDPIIDYTIDTELPGTCSIKPHHVIGDEFWYSPMLSNFDRLFEIDSRFAATLIKPSHMHNYNAIELEPGFYNRWSNPQFSTCLIPPTTEIFELLFDLPGYHQLNPLMLENKTITFETFGGRSRLKIEKLQIYQIDYYGDLITASTFQDVSRKDIFSNACDAVASLYSPTYLYRVVAINGRILPRHGSVQIKKHSPVLTSNGTREEDEFKMDGIGINDHSQLMLECTPIINLFIV
SIO_010081: YHR204W
subclass of: SO_0000673
so part of: YHR204W
location: 506319..508709
location: region:506319-508709:1
so has part: feature:506319-508709:1:exon

NP_012074.3
type: Protein
SIO_000068: ncbiprotein

S000001247
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506319-508709:1:exon

YHR205W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRM2
alternative label: KOM1
gene: SCH9
locus tag: YHR205W
gene synonym: HRM2; KOM1
so part of: sequence
location: <509363..>511837
location: region:509363-511837:1
so has part: feature:509363-511837:1:exon
subclass of: SO_0000010

856612
type: Gene
SIO_000068: ncbigene

position:509363:1
position: 509363
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511837:1
position: 511837
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:509363-511837:1:exon

YHR205W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRM2
alternative label: KOM1
gene: SCH9
locus tag: YHR205W
gene synonym: HRM2; KOM1
product: serine/threonine protein kinase SCH9
transcript id: NM_001179336.1
SIO_010081: YHR205W
subclass of: SO_0000673
so part of: YHR205W
location: <509363..>511837
location: region:509363-511837:1
so has part: feature:509363-511837:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:509363-511837:1:exon

YHR205W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRM2
alternative label: KOM1
gene: SCH9
locus tag: YHR205W
gene synonym: HRM2; KOM1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15466158|PMID:17560372|PMID:19748353|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17568771]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:17568771|PMID:25921291]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19159085|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]
experiment: EXISTENCE:genetic interaction:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19684113]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17568771]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:19684113]
experiment: EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]
experiment: EXISTENCE:mutant phenotype:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19684113]
experiment: EXISTENCE:mutant phenotype:GO:0047484 regulation of response to osmotic stress [PMID:17568771]
experiment: EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15466158]
experiment: EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:24196832]
experiment: EXISTENCE:mutant phenotype:GO:1901494 regulation of cysteine metabolic process [PMID:31582588]
experiment: EXISTENCE:mutant phenotype:GO:1904828 positive regulation of hydrogen sulfide biosynthetic process [PMID:31582588]
note: AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
codon start: 1
product: serine/threonine protein kinase SCH9
translation: MMNFFTSKSSNQDTGFSSQHQHPNGQNNGNNNSSTAGNDNGYPCKLVSSGPCASSNNGALFTNFTLQTATPTTAISQDLYAMGTTGITSENALFQMKSMNNGISSVNNNNSNTPTIITTSQEETNAGNVHGDTGGNSLQNSEDDNFSSSSTTKCLLSSTSSLSINQREAAAAAYGPDTDIPRGKLEVTIIEARDLVTRSKDSQPYVVCTFESSEFISNGPESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEHLKKKPLYTHRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNGPKNDSSHPIWHHKTTFDVLGSHSELDISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTYKQTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKSSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAMQAKFAGFTFVDESAIDEHVNNNRKFLQNSYFMEPGSFIPGNPNLPPDEDVIDDDGDEDINDGFNQEKNMNNSHSQMDFDGDQHMDDEFVSGRFEI
SIO_010081: YHR205W
subclass of: SO_0000673
so part of: YHR205W
location: 509363..511837
location: region:509363-511837:1
so has part: feature:509363-511837:1:exon

NP_012075.1
type: Protein
SIO_000068: ncbiprotein

S000001248
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:509363-511837:1:exon

YHR206W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BRY1
alternative label: POS9
gene: SKN7
locus tag: YHR206W
gene synonym: BRY1; POS9
so part of: sequence
location: <512732..>514600
location: region:512732-514600:1
so has part: feature:512732-514600:1:exon
subclass of: SO_0000010

856613
type: Gene
SIO_000068: ncbigene

position:512732:1
position: 512732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:514600:1
position: 514600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:512732-514600:1:exon

YHR206W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BRY1
alternative label: POS9
gene: SKN7
locus tag: YHR206W
gene synonym: BRY1; POS9
product: kinase-regulated stress-responsive transcription factor SKN7
transcript id: NM_001179337.3
SIO_010081: YHR206W
subclass of: SO_0000673
so part of: YHR206W
location: <512732..>514600
location: region:512732-514600:1
so has part: feature:512732-514600:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:512732-514600:1:exon

YHR206W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BRY1
alternative label: POS9
gene: SKN7
locus tag: YHR206W
gene synonym: BRY1; POS9
experiment: EXISTENCE:direct assay:GO:0000156 phosphorelay response regulator activity [PMID:11073911]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:11854400|PMID:9118942]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10888672|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11854400|PMID:9118942]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0000156 phosphorelay response regulator activity [PMID:11073911]
experiment: EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:16862604]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:9118942]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17965252]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:9118942]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]
experiment: EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:27373166]
note: Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
codon start: 1
product: kinase-regulated stress-responsive transcription factor SKN7
translation: MSFSTINSNVNKTTGDSNNNTTENSSTADLLGMDLLQSGPRLMNTMQPNNSSDMLHINNKTNNVQQPAGNTNISSANAGAKAPANEFVRKLFRILENNEYPDIVTWTENGKSFVVLDTGKFTTHILPNHFKHSNFASFVRQLNKYDFHKVKRSPEERQRCKYGEQSWEFQHPEFRVHYGKGLDNIKRKIPAQRKVLLDESQKALLHFNSEGTNPNNPSGSLLNESTTELLLSNTVSKDAFGNLRRRVDKLQKELDMSKMESYATKVELQKLNSKYNTVIESLITFKTINENLLNNFNTLCSTLANNGIEVPIFGDNGNRNPTGNTNPATTTAIQSNNNTNNASPATSTVSLQLPNLPDQNSLTPNAQNNTVTLRKGFHVLLVEDDAVSIQLCSKFLRKYGCTVQVVSDGLSAISTLEKYRYDLVLMDIVMPNLDGATATSIVRSFDNETPIIAMTGNIMNQDLITYLQHGMNDILAKPFTRDDLHSILIRYLKDRIPLCEQQLPPRNSSPQTHSNTNTANSNPNTINEQSLAMLPQDNPSTTTPVTPGASISSAQHVQQGQQEQQHQIFHAQQQQQHHNAIANARSDVAIPNLEHEINTVPHSSMGSTPQLPQSTLQENQLS
SIO_010081: YHR206W
subclass of: SO_0000673
so part of: YHR206W
location: 512732..514600
location: region:512732-514600:1
so has part: feature:512732-514600:1:exon

NP_012076.3
type: Protein
SIO_000068: ncbiprotein

S000001249
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:512732-514600:1:exon

YHR207C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SET5
locus tag: YHR207C
so part of: sequence
location: complement(<514905..>516485)
location: region:514905-516485:-1
so has part: feature:514905-516485:-1:exon
subclass of: SO_0000010

856614
type: Gene
SIO_000068: ncbigene

position:514905:-1
position: 514905
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516485:-1
position: 516485
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:514905-516485:-1:exon

YHR207C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SET5
locus tag: YHR207C
product: S-adenosylmethionine-dependent methyltransferase
transcript id: NM_001179338.1
SIO_010081: YHR207C
subclass of: SO_0000673
so part of: YHR207C
location: complement(<514905..>516485)
location: region:514905-516485:-1
so has part: feature:514905-516485:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:514905-516485:-1:exon

YHR207C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SET5
locus tag: YHR207C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22343720]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:22343720]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:27911222]
note: Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
codon start: 1
product: S-adenosylmethionine-dependent methyltransferase
translation: MTLTIKIGTLNDSDQSAVHNGTENGSDFRKITPTEEEICDDVVLLWKEEPGTEDATIQHLYDRITERNQSWKLSASRFRKILNEHHLYDTDLETVSLYKDKIHFPKALDSDAKVEVKFIDDEHGRGLFAKRDFSKGQIILKENKPIVYIPPLDKLFLISNGKACARCGKALYDLTQHKIMVHYLDCEVCKAIWCSEKCKKAHASLHELLYHSWRSNRIDILHAGNWKRFVNYCEKYCFTAAFSVGLIYGSMLLDTTGEVKEQWQKLASISQRERIKLRDASGIGSTFSLLNGTTVHTEEESDNGTKKGVEKNIDDETVWEKCYELFCGAFPKASEEIDFEKFLTMIGTFNINQYNGQVYHWISFINHDCEPNAYIEQVEEHEELRLHARKPIKKGEQIRITYVNPLHGVRLRRRELRVNWGFLCQCDRCQNELSTFERVPNLEKKNADANLGVEKIDSNDSSEDGSKKSTGNRKSSMREAQPDLKEILKNGKEFELDIPETVDTQGNVRKTSVRFDSNVSVAVDER
SIO_010081: YHR207C
subclass of: SO_0000673
so part of: YHR207C
location: complement(514905..516485)
location: region:514905-516485:-1
so has part: feature:514905-516485:-1:exon

NP_012077.1
type: Protein
SIO_000068: ncbiprotein

S000001250
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:514905-516485:-1:exon

YHR208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ECA39
alternative label: TWT1
gene: BAT1
locus tag: YHR208W
gene synonym: ECA39; TWT1
so part of: sequence
location: <517532..>518713
location: region:517532-518713:1
so has part: feature:517532-518713:1:exon
subclass of: SO_0000010

856615
type: Gene
SIO_000068: ncbigene

position:517532:1
position: 517532
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:518713:1
position: 518713
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:517532-518713:1:exon

YHR208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ECA39
alternative label: TWT1
gene: BAT1
locus tag: YHR208W
gene synonym: ECA39; TWT1
product: branched-chain-amino-acid transaminase BAT1
transcript id: NM_001179339.3
SIO_010081: YHR208W
subclass of: SO_0000673
so part of: YHR208W
location: <517532..>518713
location: region:517532-518713:1
so has part: feature:517532-518713:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:517532-518713:1:exon

YHR208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ECA39
alternative label: TWT1
gene: BAT1
locus tag: YHR208W
gene synonym: ECA39; TWT1
EC number: 2.6.1.42
experiment: EXISTENCE:direct assay:GO:0004084 branched-chain-amino-acid transaminase activity [PMID:8798704]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8798704]
experiment: EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]
experiment: EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]
experiment: EXISTENCE:mutant phenotype:GO:0009083 branched-chain amino acid catabolic process [PMID:8702755]
note: Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication
codon start: 1
product: branched-chain-amino-acid transaminase BAT1
translation: MLQRHSLKLGKFSIRTLATGAPLDASKLKITRNPNPSKPRPNEELVFGQTFTDHMLTIPWSAKEGWGTPHIKPYGNLSLDPSACVFHYAFELFEGLKAYRTPQNTITMFRPDKNMARMNKSAARICLPTFESEELIKLTGKLIEQDKHLVPQGNGYSLYIRPTMIGTSKGLGVGTPSEALLYVITSPVGPYYKTGFKAVRLEATDYATRAWPGGVGDKKLGANYAPCILPQLQAAKRGYQQNLWLFGPEKNITEVGTMNVFFVFLNKVTGKKELVTAPLDGTILEGVTRDSVLTLARDKLDPQEWDINERYYTITEVATRAKQGELLEAFGSGTAAVVSPIKEIGWNNEDIHVPLLPGEQCGALTKQVAQWIADIQYGRVNYGNWSKTVADLN
SIO_010081: YHR208W
subclass of: SO_0000673
so part of: YHR208W
location: 517532..518713
location: region:517532-518713:1
so has part: feature:517532-518713:1:exon

NP_012078.3
type: Protein
SIO_000068: ncbiprotein

S000001251
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:517532-518713:1:exon

YHR209W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CRG1
locus tag: YHR209W
so part of: sequence
location: <519437..>520312
location: region:519437-520312:1
so has part: feature:519437-520312:1:exon
subclass of: SO_0000010

856616
type: Gene
SIO_000068: ncbigene

position:519437:1
position: 519437
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520312:1
position: 520312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:519437-520312:1:exon

YHR209W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CRG1
locus tag: YHR209W
product: S-adenosylmethionine-dependent methyltransferase
transcript id: NM_001179340.1
SIO_010081: YHR209W
subclass of: SO_0000673
so part of: YHR209W
location: <519437..>520312
location: region:519437-520312:1
so has part: feature:519437-520312:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:519437-520312:1:exon

YHR209W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CRG1
locus tag: YHR209W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]
experiment: EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:22028670]
experiment: EXISTENCE:mutant phenotype:GO:0008168 methyltransferase activity [PMID:22028670]
experiment: EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:22028670]
note: S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
codon start: 1
product: S-adenosylmethionine-dependent methyltransferase
translation: MPKTSYLNKNFESAHYNNVRPSYPLSLVNEIMKFHKGTRKSLVDIGCGTGKATFVVEPYFKEVIGIDPSSAMLSIAEKETNERRLDKKIRFINAPGEDLSSIRPESVDMVISAEAIHWCNLERLFQQVSSILRSDGTFAFWFYIQPEFVDFPEALNVYYKYGWSKDYMGKYLNDNQREILLNYGGEKLRSLLSDRFGDIEVTIYSPSDPNASTVTAENSQFLWRAAITLNQFKEFVKSWSIYTSWARDNPSKPDIADIFINELKEICHCEDLNVPLKIEWSTFYYLCRKRE
SIO_010081: YHR209W
subclass of: SO_0000673
so part of: YHR209W
location: 519437..520312
location: region:519437-520312:1
so has part: feature:519437-520312:1:exon

NP_012079.1
type: Protein
SIO_000068: ncbiprotein

S000001252
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:519437-520312:1:exon

YHR210C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR210C
so part of: sequence
location: complement(<520712..>521737)
location: region:520712-521737:-1
so has part: feature:520712-521737:-1:exon
subclass of: SO_0000010

856617
type: Gene
SIO_000068: ncbigene

position:520712:-1
position: 520712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:521737:-1
position: 521737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520712-521737:-1:exon

YHR210C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR210C
product: aldose 1-epimerase superfamily protein
transcript id: NM_001179341.3
SIO_010081: YHR210C
subclass of: SO_0000673
so part of: YHR210C
location: complement(<520712..>521737)
location: region:520712-521737:-1
so has part: feature:520712-521737:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:520712-521737:-1:exon

YHR210C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR210C
note: Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions
codon start: 1
product: aldose 1-epimerase superfamily protein
translation: MSNNKAGGEYEVITIGDAKKLQATISELGATLLDLKVNNESIVLGYPDIHGYISDGYNYIGATVGRYANRIYKGMFSMEDGPHQLTVNNCGNTNHSSISSFHLKKYKASKVQNPLDDLYIVEFTLLDDRTLPNEFPGDLAVNLKYTLNVADMTLDLEYEAKLVSGEATPINMTNHTYFNLNKTMDKKSISGTEVRLCSDKSLEVSEGALIPTGKIVQRKIATFDSSKPTILQDDGPIYDYAFIVDENKNLKTTDSVSVNKLVPAFKAYHPASRLSLEVSTTEPTVLFYTGDNLCDGFTPRSGFAVEQGRYVDAINRDGWRDCVLLRRGEVYTSKTRYRFAV
SIO_010081: YHR210C
subclass of: SO_0000673
so part of: YHR210C
location: complement(520712..521737)
location: region:520712-521737:-1
so has part: feature:520712-521737:-1:exon

NP_012080.3
type: Protein
SIO_000068: ncbiprotein

S000001253
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:520712-521737:-1:exon

YHR211W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FLO5
locus tag: YHR211W
so part of: sequence
location: <525392..>528619
location: region:525392-528619:1
so has part: feature:525392-528619:1:exon
subclass of: SO_0000010

856618
type: Gene
SIO_000068: ncbigene

position:525392:1
position: 525392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:528619:1
position: 528619
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525392-528619:1:exon

YHR211W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FLO5
locus tag: YHR211W
product: flocculin FLO5
transcript id: NM_001179342.1
SIO_010081: YHR211W
subclass of: SO_0000673
so part of: YHR211W
location: <525392..>528619
location: region:525392-528619:1
so has part: feature:525392-528619:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525392-528619:1:exon

YHR211W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FLO5
locus tag: YHR211W
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9483793]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19420680|PMID:19087208]
experiment: EXISTENCE:mutant phenotype:GO:0005537 mannose binding [PMID:2665372]
experiment: EXISTENCE:mutant phenotype:GO:0031589 cell-substrate adhesion [PMID:19087208]
note: Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication
codon start: 1
product: flocculin FLO5
translation: MTIAHHCIFLVILAFLALINVASGATEACLPAGQRKSGMNINFYQYSLKDSSTYSNAAYMAYGYASKTKLGSVGGQTDISIDYNIPCVSSSGTFPCPQEDSYGNWGCKGMGACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFSFATVDDSAILSVGGSIAFECCAQEQPPITSTNFTINGIKPWDGSLPDNITGTVYMYAGYYYPLKVVYSNAVSWGTLPISVELPDGTTVSDNFEGYVYSFDDDLSQSNCTIPDPSIHTTSTITTTTEPWTGTFTSTSTEMTTITDTNGQLTDETVIVIRTPTTASTITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITRTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTTAISSSLSSSSGQITSSITSSRPIITPFYPSNGTSVISSSVISSSVTSSLVTSSSFISSSVISSSTTTSTSIFSESSTSSVIPTSSSTSGSSESKTSSASSSSSSSSISSESPKSPTNSSSSLPPVTSATTGQETASSLPPATTTKTSEQTTLVTVTSCESHVCTESISSAIVSTATVTVSGVTTEYTTWCPISTTETTKQTKGTTEQTKGTTEQTTETTKQTTVVTISSCESDICSKTASPAIVSTSTATINGVTTEYTTWCPISTTESKQQTTLVTVTSCESGVCSETTSPAIVSTATATVNDVVTVYPTWRPQTTNEQSVSSKMNSATSETTTNTGAAETKTAVTSSLSRFNHAETQTASATDVIGHSSSVVSVSETGNTMSLTSSGLSTMSQQPRSTPASSMVGSSTASLEISTYAGSANSLLAGSGLSVFIASLLLAII
SIO_010081: YHR211W
subclass of: SO_0000673
so part of: YHR211W
location: 525392..528619
location: region:525392-528619:1
so has part: feature:525392-528619:1:exon

NP_012081.1
type: Protein
SIO_000068: ncbiprotein

S000001254
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525392-528619:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(530049..530379)
location: region:530049-530379:-1
so has part: feature:530049-530379:-1:region

S000007000
type: SGD
SIO_000068: sgd

position:530049:-1
position: 530049
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:530379:-1
position: 530379
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:530049-530379:-1:region

YHR212W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR212W-A
so part of: sequence
location: <538742..>538945
location: region:538742-538945:1
so has part: feature:538742-538945:1:exon
subclass of: SO_0000010

1466531
type: Gene
SIO_000068: ncbigene

position:538742:1
position: 538742
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538945:1
position: 538945
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538742-538945:1:exon

YHR212W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR212W-A
product: uncharacterized protein
transcript id: NM_001184598.3
SIO_010081: YHR212W-A
subclass of: SO_0000673
so part of: YHR212W-A
location: <538742..>538945
location: region:538742-538945:1
so has part: feature:538742-538945:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538742-538945:1:exon

YHR212W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR212W-A
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MPYHYLFLALFTYLATSNVVSGSTQACLPVGPRKNGMNVNFYKYSLLDSTTYSYPQYMTSGYASNWN
SIO_010081: YHR212W-A
subclass of: SO_0000673
so part of: YHR212W-A
location: 538742..538945
location: region:538742-538945:1
so has part: feature:538742-538945:1:exon

NP_878091.3
type: Protein
SIO_000068: ncbiprotein

S000028650
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538742-538945:1:exon

YHR213W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR213W
so part of: sequence
location: <539151..>539747
location: region:539151-539747:1
so has part: feature:539151-539747:1:exon
subclass of: SO_0000010

856620
type: Gene
SIO_000068: ncbigene

position:539151:1
position: 539151
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:539747:1
position: 539747
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:539151-539747:1:exon

YHR213W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR213W
product: uncharacterized protein
transcript id: NM_001179344.1
SIO_010081: YHR213W
subclass of: SO_0000673
so part of: YHR213W
location: <539151..>539747
location: region:539151-539747:1
so has part: feature:539151-539747:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:539151-539747:1:exon

YHR213W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR213W
note: Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MTGYFLPPQTSSYTFRFAKVDDSAILSVGGNVAFECCAQEQPPITSTDFTINGIKPWQGSLPDNIGGTVYMYAGYYYPLKVVYSNAVSWGTLPISVELPDGTTVSDDFEGYVYSFDDDLSQSNCTIPDPSKHTTSIVTTTTELWTGTFTSTSTEMTTVTGTNGQPTDETVIVAKAPTTATSSSLSSSSSEQITSSITS
SIO_010081: YHR213W
subclass of: SO_0000673
so part of: YHR213W
location: 539151..539747
location: region:539151-539747:1
so has part: feature:539151-539747:1:exon

NP_012083.1
type: Protein
SIO_000068: ncbiprotein

S000001256
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:539151-539747:1:exon

YHR213W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR213W-A
so part of: sequence
location: <540549..>540782
location: region:540549-540782:1
so has part: feature:540549-540782:1:exon
subclass of: SO_0000010

1466532
type: Gene
SIO_000068: ncbigene

position:540549:1
position: 540549
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540782:1
position: 540782
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540549-540782:1:exon

YHR213W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR213W-A
product: uncharacterized protein
transcript id: NM_001184599.3
SIO_010081: YHR213W-A
subclass of: SO_0000673
so part of: YHR213W-A
location: <540549..>540782
location: region:540549-540782:1
so has part: feature:540549-540782:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540549-540782:1:exon

YHR213W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR213W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MLAKTGDVVVQKVPVIRLSVFLHFFFVFPFCLLHRLYMGMKQVQEFIMEPKGSVFVVRATLRVSLENAGKIFFNETE
SIO_010081: YHR213W-A
subclass of: SO_0000673
so part of: YHR213W-A
location: 540549..540782
location: region:540549-540782:1
so has part: feature:540549-540782:1:exon

NP_878092.3
type: Protein
SIO_000068: ncbiprotein

S000028651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540549-540782:1:exon

YHR213W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR213W-B
so part of: sequence
location: <540800..>541099
location: region:540800-541099:1
so has part: feature:540800-541099:1:exon
subclass of: SO_0000010

1466533
type: Gene
SIO_000068: ncbigene

position:540800:1
position: 540800
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:541099:1
position: 541099
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540800-541099:1:exon

YHR213W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR213W-B
product: uncharacterized protein
transcript id: NM_001184600.1
SIO_010081: YHR213W-B
subclass of: SO_0000673
so part of: YHR213W-B
location: <540800..>541099
location: region:540800-541099:1
so has part: feature:540800-541099:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540800-541099:1:exon

YHR213W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR213W-B
note: Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MLIDFCCSYIAGTHGRERAPSFTGTFVSHVSAENNCRPRRSEITQPCASGTEKKHFAATEKQCTNSLEGSRKDFLSLPLGHSYLFLFCFWRMICSEPKL
SIO_010081: YHR213W-B
subclass of: SO_0000673
so part of: YHR213W-B
location: 540800..541099
location: region:540800-541099:1
so has part: feature:540800-541099:1:exon

NP_878093.1
type: Protein
SIO_000068: ncbiprotein

S000028652
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540800-541099:1:exon

YHR214W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR214W
so part of: sequence
location: <541651..>542262
location: region:541651-542262:1
so has part: feature:541651-542262:1:exon
subclass of: SO_0000010

856621
type: Gene
SIO_000068: ncbigene

position:541651:1
position: 541651
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:542262:1
position: 542262
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541651-542262:1:exon

YHR214W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR214W
product: uncharacterized protein
transcript id: NM_001179345.3
SIO_010081: YHR214W
subclass of: SO_0000673
so part of: YHR214W
location: <541651..>542262
location: region:541651-542262:1
so has part: feature:541651-542262:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:541651-542262:1:exon

YHR214W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR214W
note: hypothetical protein; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MFNRFNKFQAAVALALLSRGALGDSYTNSTSSADLSSITSVSSASASATASDSLSSSDGTVYLPSTTISGDLTVTGKVIATEAVEVAAGGKLTLLDGEKYVFSSDLKVHGDLVVEKSEASYEGTAFDVSGETFEVSGNFSAEETGAVSASIYSFTPSSFKSSGDISLSLSKAKKGEVTFSPYSNAGTFSLSNAILNGGSVSGL
SIO_010081: YHR214W
subclass of: SO_0000673
so part of: YHR214W
location: 541651..542262
location: region:541651-542262:1
so has part: feature:541651-542262:1:exon

NP_012084.3
type: Protein
SIO_000068: ncbiprotein

S000001257
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541651-542262:1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YHRCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YHRCTy1-1
so part of: sequence
location: complement(543610..549637)
location: region:543610-549637:-1
so has part: feature:543610-549637:-1:region

S000007006
type: SGD
SIO_000068: sgd

position:543610:-1
position: 543610
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:549637:-1
position: 549637
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:543610-549637:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(543610..543941)
location: region:543610-543941:-1
so has part: feature:543610-543941:-1:region

S000007001
type: SGD
SIO_000068: sgd

position:543941:-1
position: 543941
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:543610-543941:-1:region

YHR214C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR214C-B
so part of: sequence
location: complement(<543964..>549346)
location: region:543964-549346:-1
so has part: feature:543964-549346:-1:exon
subclass of: SO_0000010

856623
type: Gene
SIO_000068: ncbigene

position:543964:-1
position: 543964
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549346:-1
position: 549346
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:543964-549346:-1:exon

YHR214C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR214C-B
product: gag-pol fusion protein
transcript id: NM_001181431.2
SIO_010081: YHR214C-B
subclass of: SO_0000673
so part of: YHR214C-B
location: complement(<543964..>549346)
location: region:543964-549346:-1
so has part: feature:543964-549346:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:543964-549346:-1:exon

YHR214C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR214C-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; YHR214C-B has a paralog, YAR070C, that arose from a segmental duplication
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLMMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YHR214C-B
subclass of: SO_0000673
so part of: YHR214C-B
location: complement(join(543964..547929,547931..549346))
location: region:543964-549346:-1
so has part: feature:547931-549346:-1:exon
so has part: feature:543964-547929:-1:exon

NP_012086.1
type: Protein
SIO_000068: ncbiprotein

S000003534
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547931-549346:-1:exon

position:547931:-1
position: 547931
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:543964-547929:-1:exon

position:547929:-1
position: 547929
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YHR214C-C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR214C-C
so part of: sequence
location: complement(<547910..>549346)
location: region:547910-549346:-1
so has part: feature:547910-549346:-1:exon
subclass of: SO_0000010

856624
type: Gene
SIO_000068: ncbigene

position:547910:-1
position: 547910
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:547910-549346:-1:exon

YHR214C-C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR214C-C
product: gag protein
transcript id: NM_001184437.3
SIO_010081: YHR214C-C
subclass of: SO_0000673
so part of: YHR214C-C
location: complement(<547910..>549346)
location: region:547910-549346:-1
so has part: feature:547910-549346:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:547910-549346:-1:exon

YHR214C-C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR214C-C
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENLHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YHR214C-C
subclass of: SO_0000673
so part of: YHR214C-C
location: complement(547910..549346)
location: region:547910-549346:-1
so has part: feature:547910-549346:-1:exon

NP_036195.3
type: Protein
SIO_000068: ncbiprotein

S000007421
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:547910-549346:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(549306..549637)
location: region:549306-549637:-1
so has part: feature:549306-549637:-1:region

S000007002
type: SGD
SIO_000068: sgd

position:549306:-1
position: 549306
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549306-549637:-1:region

YHR214C-D
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR214C-D
so part of: sequence
location: complement(<550648..>550941)
location: region:550648-550941:-1
so has part: feature:550648-550941:-1:exon
subclass of: SO_0000010

1466534
type: Gene
SIO_000068: ncbigene

position:550648:-1
position: 550648
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550941:-1
position: 550941
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:550648-550941:-1:exon

YHR214C-D
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR214C-D
product: uncharacterized protein
transcript id: NM_001184601.1
SIO_010081: YHR214C-D
subclass of: SO_0000673
so part of: YHR214C-D
location: complement(<550648..>550941)
location: region:550648-550941:-1
so has part: feature:550648-550941:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:550648-550941:-1:exon

YHR214C-D
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR214C-D
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication
codon start: 1
product: uncharacterized protein
translation: MEDHTLVAIVVFFGNGEPFHVSLSVEMVFVLLLSSTRIHEVVVLICYKLQHATWSWGNMSKNFSLKPDISLSFLLDIISINDICIYGCIALTVVFIL
SIO_010081: YHR214C-D
subclass of: SO_0000673
so part of: YHR214C-D
location: complement(550648..550941)
location: region:550648-550941:-1
so has part: feature:550648-550941:-1:exon

NP_878094.1
type: Protein
SIO_000068: ncbiprotein

S000028653
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:550648-550941:-1:exon

YHR214C-E
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR214C-E
so part of: sequence
location: complement(<551200..>551499)
location: region:551200-551499:-1
so has part: feature:551200-551499:-1:exon
subclass of: SO_0000010

1466535
type: Gene
SIO_000068: ncbigene

position:551200:-1
position: 551200
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551499:-1
position: 551499
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551200-551499:-1:exon

YHR214C-E
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR214C-E
product: uncharacterized protein
transcript id: NM_001184602.3
SIO_010081: YHR214C-E
subclass of: SO_0000673
so part of: YHR214C-E
location: complement(<551200..>551499)
location: region:551200-551499:-1
so has part: feature:551200-551499:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551200-551499:-1:exon

YHR214C-E
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR214C-E
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MYKITTIYLWLKSYLSFFIGLDNLDFLTLIRFFQCRLQNKLGLQDILDFFCNLCGHSMVRTCNMVEAAQKQNRITFGSIYVKLHPLVKLCTGIVWAPRV
SIO_010081: YHR214C-E
subclass of: SO_0000673
so part of: YHR214C-E
location: complement(551200..551499)
location: region:551200-551499:-1
so has part: feature:551200-551499:-1:exon

NP_878095.3
type: Protein
SIO_000068: ncbiprotein

S000028654
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551200-551499:-1:exon

YHR215W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PHO10
gene: PHO12
locus tag: YHR215W
gene synonym: PHO10
so part of: sequence
location: <552099..>553502
location: region:552099-553502:1
so has part: feature:552099-553502:1:exon
subclass of: SO_0000010

856625
type: Gene
SIO_000068: ncbigene

position:552099:1
position: 552099
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:553502:1
position: 553502
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552099-553502:1:exon

YHR215W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PHO10
gene: PHO12
locus tag: YHR215W
gene synonym: PHO10
product: acid phosphatase PHO12
transcript id: NM_001179346.1
SIO_010081: YHR215W
subclass of: SO_0000673
so part of: YHR215W
location: <552099..>553502
location: region:552099-553502:1
so has part: feature:552099-553502:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552099-553502:1:exon

YHR215W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PHO10
gene: PHO12
locus tag: YHR215W
gene synonym: PHO10
EC number: 3.1.3.2
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:8817921]
note: One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication
codon start: 1
product: acid phosphatase PHO12
translation: MLKSAVYSILAASLVNAGTIPLGKLSDIDKIGTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIMTTWYKLSNYTGQFSGALSFLNDDYEFFIRDTKNLEMETTLANSVNVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKFNISLQTISEAESAGANTLSAHHSCPAWDDDVNDDILKKYDTKYLSGIAKRLNKENKGLNLTSSDANTFFAWCAYEINARGYSDICNIFTKDELVRFSYGQDLETYYQTGPGYDVVRSVGANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFMENTFHRSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYGYAEKRVAGTDFLKVCNVSSVSNSTELTFFWDWNTKHYNDTLLKQ
SIO_010081: YHR215W
subclass of: SO_0000673
so part of: YHR215W
location: 552099..553502
location: region:552099-553502:1
so has part: feature:552099-553502:1:exon

NP_012087.1
type: Protein
SIO_000068: ncbiprotein

S000001258
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552099-553502:1:exon

YHR216W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PUR5
gene: IMD2
locus tag: YHR216W
gene synonym: PUR5
so part of: sequence
location: <554396..>555967
location: region:554396-555967:1
so has part: feature:554396-555967:1:exon
subclass of: SO_0000010

856626
type: Gene
SIO_000068: ncbigene

position:554396:1
position: 554396
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:555967:1
position: 555967
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554396-555967:1:exon

YHR216W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PUR5
gene: IMD2
locus tag: YHR216W
gene synonym: PUR5
product: IMP dehydrogenase IMD2
transcript id: NM_001179347.3
SIO_010081: YHR216W
subclass of: SO_0000673
so part of: YHR216W
location: <554396..>555967
location: region:554396-555967:1
so has part: feature:554396-555967:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554396-555967:1:exon

YHR216W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PUR5
gene: IMD2
locus tag: YHR216W
gene synonym: PUR5
EC number: 1.1.1.205
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:20097157]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:20097157]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]
note: Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication
codon start: 1
product: IMP dehydrogenase IMD2
translation: MAAIRDYKTALDFTKSLPRPDGLSVQELMDSKIRGGLTYNDFLILPGLVDFASSEVSLQTKLTRNITLNIPLVSSPMDTVTESEMATFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKEKYGFAGFPVTTDGKRNAKLVGVITSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGRLLVVDEKGNLVSMLSRTDLMKNQNYPLASKSANTKQLLCGASIGTMDADKERLRLLVKAGLDVVILDSSQGNSIFELNMLKWVKESFPGLEVIAGNVVTREQAANLIAAGADGLRIGMGTGSICITQEVMACGRPQGTAVYNVCEFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKNNVQRGKVRFEFRTASAQLEGGVHNLHSYEKRLHN
SIO_010081: YHR216W
subclass of: SO_0000673
so part of: YHR216W
location: 554396..555967
location: region:554396-555967:1
so has part: feature:554396-555967:1:exon

NP_012088.3
type: Protein
SIO_000068: ncbiprotein

S000001259
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554396-555967:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS824; Autonomously Replicating Sequence
so part of: sequence
location: 556001..556331
location: region:556001-556331:1
so has part: feature:556001-556331:1:region

S000118363
type: SGD
SIO_000068: sgd

position:556001:1
position: 556001
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:556331:1
position: 556331
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:556001-556331:1:region

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL08R; Telomeric region on the right arm of Chromosome VIII; composed of an X element core sequence, X element combinatorial repeats, an internal stretch of telomeric repeats, a short Y' element, and a terminal stretch of telomeric repeats
so part of: sequence
location: 556105..562643
location: region:556105-562643:1
so has part: feature:556105-562643:1:region

S000028964
type: SGD
SIO_000068: sgd

position:556105:1
position: 556105
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:556105-562643:1:region

YHR218W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR218W
so part of: sequence
location: <558014..>559924
location: region:558014-559924:1
so has part: feature:558014-559924:1:exon
subclass of: SO_0000010

856628
type: Gene
SIO_000068: ncbigene

position:558014:1
position: 558014
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:559924:1
position: 559924
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:558014-559924:1:exon

YHR218W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR218W
product: uncharacterized protein
transcript id: NM_001179349.1
SIO_010081: YHR218W
subclass of: SO_0000673
so part of: YHR218W
location: join(<558014..558615,558715..>559924)
location: region:558014-559924:1
so has part: feature:558014-558615:1:exon
so has part: feature:558715-559924:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:558014-558615:1:exon

position:558615:1
position: 558615
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:558715-559924:1:exon

position:558715:1
position: 558715
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YHR218W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR218W
note: Helicase-like protein encoded within the telomeric Y' element
codon start: 1
product: uncharacterized protein
translation: MDRKRSFEKIVVSVMVGKNVQKFLTFVEDEPDFQGGPIPSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCYEIASARPNDSSTMRTFTDFVSGTPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDVLATAQRIRRRYNKNGSSEPRLKTLDGLTSERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHDQKISRVTRKRPREPKSTNDILVAGRKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRRGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGCCRKGVSHKGVCH
SIO_010081: YHR218W
subclass of: SO_0000673
so part of: YHR218W
location: join(558014..558615,558715..559924)
location: region:558014-559924:1
so has part: feature:558014-558615:1:exon
so has part: feature:558715-559924:1:exon

NP_012090.1
type: Protein
SIO_000068: ncbiprotein

S000001261
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:558014-558615:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:558715-559924:1:exon

YHR219W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YHR219W
so part of: sequence
location: <560173..>562047
location: region:560173-562047:1
so has part: feature:560173-562047:1:exon
subclass of: SO_0000010

856629
type: Gene
SIO_000068: ncbigene

position:560173:1
position: 560173
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:562047:1
position: 562047
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560173-562047:1:exon

YHR219W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YHR219W
product: uncharacterized protein
transcript id: NM_001179350.3
SIO_010081: YHR219W
subclass of: SO_0000673
so part of: YHR219W
location: <560173..>562047
location: region:560173-562047:1
so has part: feature:560173-562047:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560173-562047:1:exon

YHR219W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YHR219W
note: hypothetical protein with similarity to helicases; located in the telomere region on the right arm of chromosome VIII
codon start: 1
product: uncharacterized protein
translation: MDLNQRKEKKGQHVGCCGSRTDLSADTVELIERMDRLAENQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASINVRTSATTTASINVRTSATTTESTNSNTNATTTESTNSSTNATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKFFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWVDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
SIO_010081: YHR219W
subclass of: SO_0000673
so part of: YHR219W
location: 560173..562047
location: region:560173-562047:1
so has part: feature:560173-562047:1:exon

NP_012091.3
type: Protein
SIO_000068: ncbiprotein

S000001262
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560173-562047:1:exon