Saccharomyces cerevisiae S288C chromosome VII, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome VII, complete sequence.
sequence version: NC_001139.9
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001139.9
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169869
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006941.\n\nOn Apr 26, 2011 this sequence version replaced NC_001139.8.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 1090940
topology: linear
so has quality: SO_0000987
location: 1..1090940
location: region:1-1090940:1
RO_0002162: 559292

NC_001139
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
author: Tettelin, H.
author: Agostoni Carbone, M.L.
author: Albermann, K.
author: Albers, M.
author: Arroyo, J.
author: Backes, U.
author: Barreiros, T.
author: Bertani, I.
author: Bjourson, A.J.
author: Bruckner, M.
author: Bruschi, C.V.
author: Carignani, G.
author: Castagnoli, L.
author: Cerdan, E.
author: Clemente, M.L.
author: Coblenz, A.
author: Coglievina, M.
author: Coissac, E.
author: Defoor, E.
author: Del Bino, S.
author: Delius, H.
author: Delneri, D.
author: de Wergifosse, P.
author: Dujon, B.
author: Kleine, K. et al.
journal: Nature 387 (6632 SUPPL), 81-84 (1997)
pubmed: 9169869

9169869
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

7
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

8
title: Direct Submission
journal: Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1090940:1
position: 1090940
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-1090940:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: VII

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL07L; Telomeric region on the left arm of Chromosome VII; composed of an X element core sequence, X element combinatorial repeats, and a short terminal stretch of telomeric repeats
so part of: sequence
location: complement(1..781)
location: region:1-781:-1
so has part: feature:1-781:-1:region

S000028887
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:781:-1
position: 781
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-781:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty5 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 838..1079
location: region:838-1079:1
so has part: feature:838-1079:1:region

S000006948
type: SGD
SIO_000068: sgd

position:838:1
position: 838
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:1079:1
position: 1079
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:838-1079:1:region

YGL263W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COS12
locus tag: YGL263W
so part of: sequence
location: <2790..>3932
location: region:2790-3932:1
so has part: feature:2790-3932:1:exon
subclass of: SO_0000010

852628
type: Gene
SIO_000068: ncbigene

position:2790:1
position: 2790
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:3932:1
position: 3932
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:2790-3932:1:exon

YGL263W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COS12
locus tag: YGL263W
product: Cos12p
transcript id: NM_001181129.1
SIO_010081: YGL263W
subclass of: SO_0000673
so part of: YGL263W
location: <2790..>3932
location: region:2790-3932:1
so has part: feature:2790-3932:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:2790-3932:1:exon

YGL263W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COS12
locus tag: YGL263W
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
note: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
codon start: 1
product: Cos12p
translation: MDGAKFENTVAFLPSEIFDCYNSTLPKNVFRSFVTWSCYEKFNSLEFRTWLLMWLPLIIAWKIRGKRHYLVIVTALMFEVLYFLWTYSYIFRERTLGKQVSQFAKEIITNTPGIDTEDWERVAVNFNSYLYENKLWNTEYFFFDGSSCQEAFRKMLLEPFSLKKNDFANAKVPDGSVCYTEKALQVYFTQIERKWHWINSEGFLHNKTTQSVQFSKHGYGSKLLWAFKEVTIMNSRFAFFSIAYLNGLLTIPRLRNSLHILYVCAVLSSMIIEYLIGIDKFRFKSMNLIHKLQFLSYITCGHEKSDATNWSQIAKRTNTYMFEQKIWNSPILFSDGIDCEKFFKWYFSTPVSSQASLSVGSTDFELWPYIKEAQSACNDV
SIO_010081: YGL263W
subclass of: SO_0000673
so part of: YGL263W
location: 2790..3932
location: region:2790-3932:1
so has part: feature:2790-3932:1:exon

NP_011251.1
type: Protein
SIO_000068: ncbiprotein

S000003232
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:2790-3932:1:exon

YGL262W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL262W
so part of: sequence
location: <5312..>5839
location: region:5312-5839:1
so has part: feature:5312-5839:1:exon
subclass of: SO_0000010

852629
type: Gene
SIO_000068: ncbigene

position:5312:1
position: 5312
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5839:1
position: 5839
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5312-5839:1:exon

YGL262W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL262W
product: uncharacterized protein
transcript id: NM_001181128.1
SIO_010081: YGL262W
subclass of: SO_0000673
so part of: YGL262W
location: <5312..>5839
location: region:5312-5839:1
so has part: feature:5312-5839:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:5312-5839:1:exon

YGL262W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL262W
note: hypothetical protein; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MRNNVTELVNSIIGVQTPGSLPDTLSGAHSLQRRISYFDVNWISWNWDNVNVDLNKEVKKSRPLLGEEDDQCMFGWFANNPGWKYYWSVTDNPDPGYKENYSDIGDENAVHGELYFNTYGGLMASVMTTKMVLNAKRQLVVIDTIVVKAICDYVMKYWKKKVNLTTISLYLMLKL
SIO_010081: YGL262W
subclass of: SO_0000673
so part of: YGL262W
location: 5312..5839
location: region:5312-5839:1
so has part: feature:5312-5839:1:exon

NP_011252.1
type: Protein
SIO_000068: ncbiprotein

S000003231
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:5312-5839:1:exon

YGL261C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU11
locus tag: YGL261C
so part of: sequence
location: complement(<6290..>6652)
location: region:6290-6652:-1
so has part: feature:6290-6652:-1:exon
subclass of: SO_0000010

852630
type: Gene
SIO_000068: ncbigene

position:6290:-1
position: 6290
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:6652:-1
position: 6652
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6290-6652:-1:exon

YGL261C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU11
locus tag: YGL261C
product: seripauperin PAU11
transcript id: NM_001181127.1
SIO_010081: YGL261C
subclass of: SO_0000673
so part of: YGL261C
location: complement(<6290..>6652)
location: region:6290-6652:-1
so has part: feature:6290-6652:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6290-6652:-1:exon

YGL261C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU11
locus tag: YGL261C
note: hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
codon start: 1
product: seripauperin PAU11
translation: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYMFQAAHPTETYPVEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN
SIO_010081: YGL261C
subclass of: SO_0000673
so part of: YGL261C
location: complement(6290..6652)
location: region:6290-6652:-1
so has part: feature:6290-6652:-1:exon

NP_011253.1
type: Protein
SIO_000068: ncbiprotein

S000003230
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6290-6652:-1:exon

YGL260W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL260W
so part of: sequence
location: <6860..>7090
location: region:6860-7090:1
so has part: feature:6860-7090:1:exon
subclass of: SO_0000010

852631
type: Gene
SIO_000068: ncbigene

position:6860:1
position: 6860
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:7090:1
position: 7090
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6860-7090:1:exon

YGL260W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL260W
product: uncharacterized protein
transcript id: NM_001181126.1
SIO_010081: YGL260W
subclass of: SO_0000673
so part of: YGL260W
location: <6860..>7090
location: region:6860-7090:1
so has part: feature:6860-7090:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:6860-7090:1:exon

YGL260W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL260W
note: hypothetical protein; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
codon start: 1
product: uncharacterized protein
translation: MEMLLFLNESYIFHRLRMWSIVLWHSCVFVCAECGNANYRVPRCLIKPFSVPVTFPFSVKKNIRILDLDPRTEAYC
SIO_010081: YGL260W
subclass of: SO_0000673
so part of: YGL260W
location: 6860..7090
location: region:6860-7090:1
so has part: feature:6860-7090:1:exon

NP_011254.1
type: Protein
SIO_000068: ncbiprotein

S000003229
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:6860-7090:1:exon

YGL259W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPS5
locus tag: YGL259W
so part of: sequence
location: <8470..>8967
location: region:8470-8967:1
so has part: feature:8470-8967:1:exon
subclass of: SO_0000010

852632
type: Gene
SIO_000068: ncbigene

position:8470:1
position: 8470
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:8967:1
position: 8967
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:8470-8967:1:exon

YGL259W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPS5
locus tag: YGL259W
product: Yps5p
transcript id: NM_001181125.1
SIO_010081: YGL259W
subclass of: SO_0000673
so part of: YGL259W
location: <8470..>8967
location: region:8470-8967:1
so has part: feature:8470-8967:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:8470-8967:1:exon

YGL259W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPS5
locus tag: YGL259W
note: Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole
codon start: 1
product: Yps5p
translation: MQLFSILSLLSSLMCSLTVLGSSASSYVKFPVQKFADIINIGTQDVSTVFKRNEVLNTTVINGIGVYVVKMEIGTPPQTVYLQLDTGSSDMIVNNADIAYCKSMSDGSDYASTDNYELTATFTGPRSTTTSPELITLSALIGVNSMQETHLLLRITRLSSMTYTY
SIO_010081: YGL259W
subclass of: SO_0000673
so part of: YGL259W
location: 8470..8967
location: region:8470-8967:1
so has part: feature:8470-8967:1:exon

NP_011255.1
type: Protein
SIO_000068: ncbiprotein

S000003228
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:8470-8967:1:exon

YGL258W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL258W-A
so part of: sequence
location: <9162..>9395
location: region:9162-9395:1
so has part: feature:9162-9395:1:exon
subclass of: SO_0000010

852633
type: Gene
SIO_000068: ncbigene

position:9162:1
position: 9162
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:9395:1
position: 9395
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:9162-9395:1:exon

YGL258W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL258W-A
product: uncharacterized protein
transcript id: NM_001184473.1
SIO_010081: YGL258W-A
subclass of: SO_0000673
so part of: YGL258W-A
location: <9162..>9395
location: region:9162-9395:1
so has part: feature:9162-9395:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:9162-9395:1:exon

YGL258W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL258W-A
codon start: 1
product: uncharacterized protein
translation: MAFERQGKIEKKISYSLFLNGPNVHFGSILFGAVDKSKYAEELCTHPMRQAYNTLDSNSRIIITVQSVAILDGKLVW
SIO_010081: YGL258W-A
subclass of: SO_0000673
so part of: YGL258W-A
location: 9162..9395
location: region:9162-9395:1
so has part: feature:9162-9395:1:exon

NP_076890.1
type: Protein
SIO_000068: ncbiprotein

S000007607
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:9162-9395:1:exon

YGL258W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VEL1
locus tag: YGL258W
so part of: sequence
location: <11110..>11730
location: region:11110-11730:1
so has part: feature:11110-11730:1:exon
subclass of: SO_0000010

852634
type: Gene
SIO_000068: ncbigene

position:11110:1
position: 11110
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:11730:1
position: 11730
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:11110-11730:1:exon

YGL258W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VEL1
locus tag: YGL258W
product: Vel1p
transcript id: NM_001181124.1
SIO_010081: YGL258W
subclass of: SO_0000673
so part of: YGL258W
location: <11110..>11730
location: region:11110-11730:1
so has part: feature:11110-11730:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:11110-11730:1:exon

YGL258W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VEL1
locus tag: YGL258W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11935221]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication
codon start: 1
product: Vel1p
translation: MSFLSIFTFFSVLISVATTVRFDLTNVTCKGLHGPHCGTYVMEVVGQNGTFLGQSTFVGADVLTESAGDAWARYLGQETRFLPKLTTIASNETKNFSPLIFTTNINTCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTDYGVQVASCYPNFASVILSTPAVNIFGKDDTLPDYCTAIQLKAVCPPEAGFD
SIO_010081: YGL258W
subclass of: SO_0000673
so part of: YGL258W
location: 11110..11730
location: region:11110-11730:1
so has part: feature:11110-11730:1:exon

NP_011256.1
type: Protein
SIO_000068: ncbiprotein

S000003227
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:11110-11730:1:exon

YGL257C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MNT2
locus tag: YGL257C
so part of: sequence
location: complement(<12481..>14157)
location: region:12481-14157:-1
so has part: feature:12481-14157:-1:exon
subclass of: SO_0000010

852635
type: Gene
SIO_000068: ncbigene

position:12481:-1
position: 12481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14157:-1
position: 14157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:12481-14157:-1:exon

YGL257C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MNT2
locus tag: YGL257C
product: alpha-1,3-mannosyltransferase MNT2
transcript id: NM_001181123.1
SIO_010081: YGL257C
subclass of: SO_0000673
so part of: YGL257C
location: complement(<12481..>14157)
location: region:12481-14157:-1
so has part: feature:12481-14157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:12481-14157:-1:exon

YGL257C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MNT2
locus tag: YGL257C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:30700649]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]
experiment: EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:10521541]
experiment: EXISTENCE:mutant phenotype:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]
experiment: EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:10521541]
note: Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans
codon start: 1
product: alpha-1,3-mannosyltransferase MNT2
translation: MRRKNRLFILVVLLGIVLVVYYSQLNSLDLVEPVQSSSSGNGGCWSYYEGLTPGWLNDFYDVNQITPNPAKDVIELVTRIKIFFNCLQQVDGHNIQRLRDIEKKLFPYINFEKLETDESAFWHTTTRWNGEVYHASMLEFDPKNHQFLRSKPINFDTGLSFWENWLHTVTQSGSKGIVISASDVQLNETIRLLKVLRFIKNDYPIQIVHNADLSQDSMKSIIKYARSLDTAEYPAQELWFLNVHSLLNPKYSKKFTTYSNKWLALTFSSFEIPILMDSDTVPFVSIEKFYELEEFQKTGVLFFKDRVISDDLFESSELKILREIVYGCIGLDLEDESKIHEQVEDPVVAQVLENMFIKKYKHHLESGLVILHKGKHLFSMLTSIALQFSPIAEYFHGDKDFFWLGELLSNNRFTFHPVDASNIGQLGNVVSKESTGEFYQICSVQLSHTDRDGSLLWLNGGLNICKKTSWEYDYEHRQRLNDMFQNADELREYYASPVKLEGIIIPDTSISGWINSGECFLFNYCTLFKEGEFGKLIKFKEDEKLRLSQIVDIWNKDI
SIO_010081: YGL257C
subclass of: SO_0000673
so part of: YGL257C
location: complement(12481..14157)
location: region:12481-14157:-1
so has part: feature:12481-14157:-1:exon

NP_011257.1
type: Protein
SIO_000068: ncbiprotein

S000003226
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:12481-14157:-1:exon

YGL256W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NRC465
alternative label: ZRG5
gene: ADH4
locus tag: YGL256W
gene synonym: NRC465; ZRG5
so part of: sequence
location: <15159..>16307
location: region:15159-16307:1
so has part: feature:15159-16307:1:exon
subclass of: SO_0000010

852636
type: Gene
SIO_000068: ncbigene

position:15159:1
position: 15159
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:16307:1
position: 16307
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:15159-16307:1:exon

YGL256W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NRC465
alternative label: ZRG5
gene: ADH4
locus tag: YGL256W
gene synonym: NRC465; ZRG5
product: alcohol dehydrogenase ADH4
transcript id: NM_001181122.1
SIO_010081: YGL256W
subclass of: SO_0000673
so part of: YGL256W
location: <15159..>16307
location: region:15159-16307:1
so has part: feature:15159-16307:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:15159-16307:1:exon

YGL256W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NRC465
alternative label: ZRG5
gene: ADH4
locus tag: YGL256W
gene synonym: NRC465; ZRG5
EC number: 1.1.1.1
experiment: EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3282541]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]
experiment: EXISTENCE:mutant phenotype:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3023838]
experiment: EXISTENCE:mutant phenotype:GO:0006113 fermentation [PMID:3023838]
note: Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
codon start: 1
product: alcohol dehydrogenase ADH4
translation: MSSVTGFYIPPISFFGEGALEETADYIKNKDYKKALIVTDPGIAAIGLSGRVQKMLEERDLNVAIYDKTQPNPNIANVTAGLKVLKEQNSEIVVSIGGGSAHDNAKAIALLATNGGEIGDYEGVNQSKKAALPLFAINTTAGTASEMTRFTIISNEEKKIKMAIIDNNVTPAVAVNDPSTMFGLPPALTAATGLDALTHCIEAYVSTASNPITDACALKGIDLINESLVAAYKDGKDKKARTDMCYAEYLAGMAFNNASLGYVHALAHQLGGFYHLPHGVCNAVLLPHVQEANMQCPKAKKRLGEIALHFGASQEDPEETIKALHVLNRTMNIPRNLKELGVKTEDFEILAEHAMHDACHLTNPVQFTKEQVVAIIKKAYEY
SIO_010081: YGL256W
subclass of: SO_0000673
so part of: YGL256W
location: 15159..16307
location: region:15159-16307:1
so has part: feature:15159-16307:1:exon

NP_011258.2
type: Protein
SIO_000068: ncbiprotein

S000003225
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:15159-16307:1:exon

YGL255W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZRT1
locus tag: YGL255W
so part of: sequence
location: <20978..>22108
location: region:20978-22108:1
so has part: feature:20978-22108:1:exon
subclass of: SO_0000010

852637
type: Gene
SIO_000068: ncbigene

position:20978:1
position: 20978
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:22108:1
position: 22108
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:20978-22108:1:exon

YGL255W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZRT1
locus tag: YGL255W
product: high-affinity Zn(2+) transporter ZRT1
transcript id: NM_001181121.1
SIO_010081: YGL255W
subclass of: SO_0000673
so part of: YGL255W
location: <20978..>22108
location: region:20978-22108:1
so has part: feature:20978-22108:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:20978-22108:1:exon

YGL255W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZRT1
locus tag: YGL255W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000006 high-affinity zinc transmembrane transporter activity [PMID:8637895]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8637895]
experiment: EXISTENCE:mutant phenotype:GO:0071578 zinc ion import across plasma membrane [PMID:8637895]
note: High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
codon start: 1
product: high-affinity Zn(2+) transporter ZRT1
translation: MSNVTTPWWKQWDPSEVTLADKTPDDVWKTCVLQGVYFGGNEYNGNLGARISSVFVILFVSTFFTMFPLISTKVKRLRIPLYVYLFAKYFGSGVIVATAFIHLMDPAYGAIGGTTCVGQTGNWGLYSWCPAIMLTSLTFTFLTDLFSSVWVERKYGLSHDHTHDEIKDTVVRNTAAVSSENDNENGTANGSHDTKNGVEYYEDSDATSMDVVQSFQAQFYAFLILEFGVIFHSVMIGLNLGSVGDEFSSLYPVLVFHQSFEGLGIGARLSAIEFPRSKRWWPWALCVAYGLTTPICVAIGLGVRTRYVSGSYTALVISGVLDAISAGILLYTGLVELLARDFIFNPQRTKDLRELSFNVICTLFGAGIMALIGKWA
SIO_010081: YGL255W
subclass of: SO_0000673
so part of: YGL255W
location: 20978..22108
location: region:20978-22108:1
so has part: feature:20978-22108:1:exon

NP_011259.1
type: Protein
SIO_000068: ncbiprotein

S000003224
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:20978-22108:1:exon

YGL254W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NRC299
alternative label: RSU1
alternative label: SUL1
gene: FZF1
locus tag: YGL254W
gene synonym: NRC299; RSU1; SUL1
so part of: sequence
location: <22304..>23203
location: region:22304-23203:1
so has part: feature:22304-23203:1:exon
subclass of: SO_0000010

852638
type: Gene
SIO_000068: ncbigene

position:22304:1
position: 22304
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:23203:1
position: 23203
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:22304-23203:1:exon

YGL254W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NRC299
alternative label: RSU1
alternative label: SUL1
gene: FZF1
locus tag: YGL254W
gene synonym: NRC299; RSU1; SUL1
product: Fzf1p
transcript id: NM_001181120.1
SIO_010081: YGL254W
subclass of: SO_0000673
so part of: YGL254W
location: <22304..>23203
location: region:22304-23203:1
so has part: feature:22304-23203:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:22304-23203:1:exon

YGL254W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NRC299
alternative label: RSU1
alternative label: SUL1
gene: FZF1
locus tag: YGL254W
gene synonym: NRC299; RSU1; SUL1
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10234785]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10234785|PMID:35809138]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10234785]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10234785]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10234785]
experiment: EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:35809138]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:35809138|PMID:10870099]
note: Transcription factor involved in sulfite metabolism; activates transcription of SSU1, DDI2, DDI3; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
codon start: 1
product: Fzf1p
translation: MTDIGRTKSRNYKCSFDGCEKVYNRPSLLQQHQNSHTNQKPYHCDEPGCGKKFIRPCHLRVHKWTHSQIKPKACTLCQKRFVTNQQLRRHLNSHERKSKLASRIDRKHEGVNANVKAELNGKEGGFDPKLPSGSPMCGEEFSQGHLPGYDDMQVLQCPYKSCQKVTSFNDDLINHMLQHHIASKLVVPSGDPSLKESLPTSEKSSSTDTTSIPQLSFSTTGTSSSESVDSTTAQTPTDPESYWSDNRCKHSDCQELSPFASVFDLIDHYDHTHAFIPETLVKYSYIHLYKPSVWDLFEY
SIO_010081: YGL254W
subclass of: SO_0000673
so part of: YGL254W
location: 22304..23203
location: region:22304-23203:1
so has part: feature:22304-23203:1:exon

NP_011260.1
type: Protein
SIO_000068: ncbiprotein

S000003223
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:22304-23203:1:exon

YGL253W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEX1
alternative label: HKB
alternative label: SCI2
gene: HXK2
locus tag: YGL253W
gene synonym: HEX1; HKB; SCI2
so part of: sequence
location: <23935..>25395
location: region:23935-25395:1
so has part: feature:23935-25395:1:exon
subclass of: SO_0000010

852639
type: Gene
SIO_000068: ncbigene

position:23935:1
position: 23935
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25395:1
position: 25395
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:23935-25395:1:exon

YGL253W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEX1
alternative label: HKB
alternative label: SCI2
gene: HXK2
locus tag: YGL253W
gene synonym: HEX1; HKB; SCI2
product: hexokinase 2
transcript id: NM_001181119.1
SIO_010081: YGL253W
subclass of: SO_0000673
so part of: YGL253W
location: <23935..>25395
location: region:23935-25395:1
so has part: feature:23935-25395:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:23935-25395:1:exon

YGL253W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEX1
alternative label: HKB
alternative label: SCI2
gene: HXK2
locus tag: YGL253W
gene synonym: HEX1; HKB; SCI2
EC number: 2.7.1.1
experiment: EXISTENCE:direct assay:GO:0004396 hexokinase activity [PMID:12611889|PMID:332086]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11311123|PMID:9563516]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11311123|PMID:9563516]
experiment: EXISTENCE:direct assay:GO:0006013 mannose metabolic process [PMID:332086]
experiment: EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:332086|PMID:8917466]
experiment: EXISTENCE:direct assay:GO:0046015 regulation of transcription by glucose [PMID:11311123]
experiment: EXISTENCE:genetic interaction:GO:0046323 glucose import [PMID:6300872]
experiment: EXISTENCE:genetic interaction:GO:1990539 fructose import across plasma membrane [PMID:6300872]
experiment: EXISTENCE:mutant phenotype:GO:0004396 hexokinase activity [PMID:6341351]
experiment: EXISTENCE:mutant phenotype:GO:0006000 fructose metabolic process [PMID:6300872]
experiment: EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:6300872]
experiment: EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:8917466]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0031966 mitochondrial membrane [PMID:31862471]
experiment: EXISTENCE:mutant phenotype:GO:2001234 negative regulation of apoptotic signaling pathway [PMID:31862471]
note: Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1
codon start: 1
product: hexokinase 2
translation: MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSVGIIGA
SIO_010081: YGL253W
subclass of: SO_0000673
so part of: YGL253W
location: 23935..25395
location: region:23935-25395:1
so has part: feature:23935-25395:1:exon

NP_011261.1
type: Protein
SIO_000068: ncbiprotein

S000003222
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:23935-25395:1:exon

YGL252C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTG2
locus tag: YGL252C
so part of: sequence
location: complement(<25718..>27484)
location: region:25718-27484:-1
so has part: feature:25718-27484:-1:exon
subclass of: SO_0000010

852640
type: Gene
SIO_000068: ncbigene

position:25718:-1
position: 25718
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27484:-1
position: 27484
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25718-27484:-1:exon

YGL252C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTG2
locus tag: YGL252C
product: Rtg2p
transcript id: NM_001181118.1
SIO_010081: YGL252C
subclass of: SO_0000673
so part of: YGL252C
location: complement(<25718..>27484)
location: region:25718-27484:-1
so has part: feature:25718-27484:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25718-27484:-1:exon

YGL252C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTG2
locus tag: YGL252C
experiment: EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:12446794]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10848632]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]
experiment: EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:14536080]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]
experiment: EXISTENCE:mutant phenotype:GO:0001079 nitrogen catabolite regulation of transcription from RNA polymerase II promoter [PMID:11687605]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8422683]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11076970]
experiment: EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:7493987|PMID:8422683]
experiment: EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:10848632]
experiment: EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:12399373]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]
note: Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
codon start: 1
product: Rtg2p
translation: MSTLSDSDTETEVVSRNLCGIVDIGSNGIRFSISSKAAHHARIMPCVFKDRVGLSLYEVQYNTHTNAKCPIPRDIIKEVCSAMKRFKLICDDFGVPETSVRVIATEATRDAINADEFVNAVYGSTGWKVEILGQEDETRVGIYGVVSSFNTVRGLYLDVAGGSTQLSWVISSHGEVKQSSKPVSLPYGAGTLLRRMRTDDNRALFYEIKEAYKDAIEKIGIPQEMIDDAKKEGGFDLWTRGGGLRGMGHLLLYQSEGYPIQTIINGYACTYEEFSSMSDYLFLKQKIPGSSKEHKIFKVSDRRALQLPAVGLFMSAVFEAIPQIKAVHFSEGGVREGSLYSLLPKEIRAQDPLLIASRPYAPLLTEKYLYLLRTSIPQEDIPEIVNERIAPALCNLAFVHASYPKELQPTAALHVATRGIIAGCHGLSHRARALIGIALCSRWGGNIPESEEKYSQELEQVVLREGDKAEALRIVWWTKYIGTIMYVICGVHPGGNIRDNVFDFHVSKRSEVETSLKELIIDDANTTKVKEESTRKNRGYEVVVRISKDDLKTSASVRSRIITLQKKVRKLSRGSVERVKIGVQFYEE
SIO_010081: YGL252C
subclass of: SO_0000673
so part of: YGL252C
location: complement(25718..27484)
location: region:25718-27484:-1
so has part: feature:25718-27484:-1:exon

NP_011262.1
type: Protein
SIO_000068: ncbiprotein

S000003221
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25718-27484:-1:exon

YGL251C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MER3
gene: HFM1
locus tag: YGL251C
gene synonym: MER3
so part of: sequence
location: complement(<27921..>31636)
location: region:27921-31636:-1
so has part: feature:27921-31636:-1:exon
subclass of: SO_0000010

852641
type: Gene
SIO_000068: ncbigene

position:27921:-1
position: 27921
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31636:-1
position: 31636
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27921-31636:-1:exon

YGL251C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MER3
gene: HFM1
locus tag: YGL251C
gene synonym: MER3
product: DNA helicase
transcript id: NM_001181117.1
SIO_010081: YGL251C
subclass of: SO_0000673
so part of: YGL251C
location: complement(join(<27921..31426,31579..>31636))
location: region:27921-31636:-1
so has part: feature:31579-31636:-1:exon
so has part: feature:27921-31426:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31579-31636:-1:exon

position:31579:-1
position: 31579
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:27921-31426:-1:exon

position:31426:-1
position: 31426
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL251C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MER3
gene: HFM1
locus tag: YGL251C
gene synonym: MER3
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:28051769]
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:11971962]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11971962]
experiment: EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:12039965]
experiment: EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:11971962]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:15805472]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280]
experiment: EXISTENCE:mutant phenotype:GO:1990166 protein localization to site of double-strand break [PMID:28051769]
note: Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
codon start: 1
product: DNA helicase
translation: MKTKFDRLGTGKRSRPSPNNIDFNDQSATFKRNKKNSRQPSFKVGLSYNSLLDDCDDENETEEIFEGRGLQFFDKDDNFSITADDTQVTSKLFDHDLEQTPDEEAKKPKKVTIRKSAKKCLSTTILPDSFRGVFKFTEFNKMQSEAFPSIYESNENCIISSPTGSGKTVLFELAILRLIKETNSDTNNTKIIYIAPTKSLCYEMYKNWFPSFVNLSVGMLTSDTSFLETEKAKKCNIIITTPEKWDLLTRRWSDYSRLFELVKLVLVDEIHTIKEKRGASLEVILTRMNTMCQNIRFVALSATVPNIEDLALWLKTNNELPANILSFDESYRQVQLTKFVYGYSFNCKNDFQKDAIYNSKLIEIIEKHADNRPVLIFCPTRASTISTAKFLLNNHIFSKSKKRCNHNPSDKILNECMQQGIAFHHAGISLEDRTAVEKEFLAGSINILCSTSTLAVGVNLPAYLVIIKGTKSWNSSEIQEYSDLDVLQMIGRAGRPQFETHGCAVIMTDSKMKQTYENLIHGTDVLESSLHLNLIEHLAAETSLETVYSIETAVNWLRNTFFYVRFGKNPAAYQEVNRYVSFHSVEDSQINQFCQYLLDTLVKVKIIDISNGEYKSTAYGNAMTRHYISFESMKQFINAKKFLSLQGILNLLATSEEFSVMRVRHNEKKLFKEINLSPLLKYPFLTEKKQSQIIDRVSQKVSLLIQYELGGLEFPSYEGASKLHQTLVQDKFLVFRHCFRLLKCMVDTFIEKSDGTSLKNTLFLLRSLNGHCWENTPMVLRQLKTIGLVSVRRLIRHGITNLEEMGHLSDTQIEYYLNLKIGNGIKIKNDISLLPCLNIRTKLENCKIENEELWLTFKVEISATFKSSIWHGQHLSLDIETEKSSGELIDFRRLQVNKLQSPRGFRISAKISPKLEKIEFSIHCQEIAGLGKTIVYSTDHLASQFSAKTPNIRKDLNSLEKCLFYESSSDGEVGKTSRVSHKDGLEESLSSDDSILDYLNERKKSSKAVESAAVIHPEAHSSSHFSNGRQVRSNGNYECFHSCKDKTQCRHLCCKEGIPVKYIKEKGPSSIKPVSKPDQIRQPLLAKNINTTPHLEKRLNSKPKQWQEENTDIATVHTLPSKIYNLSQQMSSMEAGEQVLKSGPENCPEIIPIDLESSDSYSSNTAASSISDPNGDLDFLGSDIEFE
SIO_010081: YGL251C
subclass of: SO_0000673
so part of: YGL251C
location: complement(join(27921..31426,31579..31636))
location: region:27921-31636:-1
so has part: feature:31579-31636:-1:exon
so has part: feature:27921-31426:-1:exon

NP_011263.2
type: Protein
SIO_000068: ncbiprotein

S000003220
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31579-31636:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:27921-31426:-1:exon

YGL250W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMR1
locus tag: YGL250W
so part of: sequence
location: <31910..>32635
location: region:31910-32635:1
so has part: feature:31910-32635:1:exon
subclass of: SO_0000010

852642
type: Gene
SIO_000068: ncbigene

position:31910:1
position: 31910
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:32635:1
position: 32635
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31910-32635:1:exon

YGL250W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMR1
locus tag: YGL250W
product: Rmr1p
transcript id: NM_001181116.1
SIO_010081: YGL250W
subclass of: SO_0000673
so part of: YGL250W
location: <31910..>32635
location: region:31910-32635:1
so has part: feature:31910-32635:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31910-32635:1:exon

YGL250W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMR1
locus tag: YGL250W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:18069899]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:18069899]
note: Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
codon start: 1
product: Rmr1p
translation: MSEEEAHKTVEVDDVGVQLDEGDEEDLLEYDDELVEEQPSDARIRNVAETLMKSELPKVTVEYKDTTFLLFTSDDKNESNNPIICENAALYQRPMGEFMESIRKFMGNRFGRLAFATKELVLQLKSLDLTLFEDNVYNNHISFSDVYTIFKILKERSESNFETDIPTHLAIELSTRPRFVSRYNALVELTESSATLKNIKPFSNDETHPLIVDDNDQYTHQNTSEVIVMDIDDDVGEDSED
SIO_010081: YGL250W
subclass of: SO_0000673
so part of: YGL250W
location: 31910..32635
location: region:31910-32635:1
so has part: feature:31910-32635:1:exon

NP_011264.2
type: Protein
SIO_000068: ncbiprotein

S000003219
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31910-32635:1:exon

YGL249W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZIP2
locus tag: YGL249W
so part of: sequence
location: <33098..>35212
location: region:33098-35212:1
so has part: feature:33098-35212:1:exon
subclass of: SO_0000010

852643
type: Gene
SIO_000068: ncbigene

position:33098:1
position: 33098
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:35212:1
position: 35212
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:33098-35212:1:exon

YGL249W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZIP2
locus tag: YGL249W
product: Zip2p
transcript id: NM_001181115.1
SIO_010081: YGL249W
subclass of: SO_0000673
so part of: YGL249W
location: <33098..>35212
location: region:33098-35212:1
so has part: feature:33098-35212:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:33098-35212:1:exon

YGL249W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZIP2
locus tag: YGL249W
experiment: EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:30566683]
experiment: EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:9590170]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:15805472]
experiment: EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:9590170]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280]
experiment: EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23326245]
note: Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
codon start: 1
product: Zip2p
translation: MIIERWEVKLSKCNQNVGGYSVLSGNLKENIKLGRRAQKYLKELRNLQLKPLKIGGYENCGTINGEEYFLEVIHITSGRQKIDVAVGKTWNVTNIENDNKEELQYELFKEKLKVGKQDMLFFSWMKSLSVQLNAPLHQKMTEHGLADDNTRLEWFNIPLLRRSQYRKKVPYPSLRQMSSVLEVQCSTLTEEKLNFCVGFSDKPLSEWKPQIFEQTYNRYRLQRISPEKSFKYKSRCSKYNFKTSSQSWVVKVPEHDQQLNTFEKRYDELFDAQFNKLEFFKIRMKKLKKNKPIEKKNYKIWCLEKEDLKDLVWDPLKRICNHSRYAIFEHVTINREAYSIKPLRLTFQKLDSGSLDLIDNQKKTFGSIKLAMSMPDVKKTENQSIEESERHDETAIETQEFDENDCLSSKADINTSLAPQKRSFIDNELMSMLVTKKKIKKDKDVSDTGISSTSYLINSGTYANSHIEIPTSNSVYNGKEDCSFNNYSVKHSILEEDIENKCIAVNENKVIENQKVIQSLCKNSHLDLIEQSYFGECDFIINHSTCVYKIQASRFMQLRNNGSLHYDKAVNDLLTEFQRVIIIVEFSEIIQDVDPDLFWKIKLYLLNSRVDVFFIHETTDFFIDWMKYFIARWAFSYNDEKEKNIANADILLDLGFNILLVRKIFQTYSLEEFFMAIIKEESKAVKMLTVSQMTRLKKLLTLEW
SIO_010081: YGL249W
subclass of: SO_0000673
so part of: YGL249W
location: 33098..35212
location: region:33098-35212:1
so has part: feature:33098-35212:1:exon

NP_011265.1
type: Protein
SIO_000068: ncbiprotein

S000003218
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:33098-35212:1:exon

YNCG0001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RME3
locus tag: YNCG0001C
so part of: sequence
location: complement(33109..35013)
location: region:33109-35013:-1
so has part: feature:33109-35013:-1:exon
subclass of: SO_0000011

23547379
type: Gene
SIO_000068: ncbigene

position:33109:-1
position: 33109
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:35013:-1
position: 35013
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:33109-35013:-1:exon

YNCG0001C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: antisense_RNA
gene: RME3
locus tag: YNCG0001C
product: RME3
note: Antisense transcript that represses the meiosis-specific ZIP2 gene; expressed in haploid cells under sporulation inducing conditions; regulates ZIP2 in a cis-dependent manner; RME3 is repressed by the MAT a1/alpha2 complex in diploid cells
transcript id: NR_132176.1
SIO_010081: YNCG0001C
subclass of: SO_0000673
so part of: YNCG0001C
location: complement(33109..35013)
location: region:33109-35013:-1
so has part: feature:33109-35013:-1:exon

S000144910
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:33109-35013:-1:exon

YGL248W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDE1
locus tag: YGL248W
so part of: sequence
location: <35653..>36762
location: region:35653-36762:1
so has part: feature:35653-36762:1:exon
subclass of: SO_0000010

852644
type: Gene
SIO_000068: ncbigene

position:35653:1
position: 35653
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36762:1
position: 36762
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:35653-36762:1:exon

YGL248W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDE1
locus tag: YGL248W
product: 3',5'-cyclic-nucleotide phosphodiesterase PDE1
transcript id: NM_001181114.1
SIO_010081: YGL248W
subclass of: SO_0000673
so part of: YGL248W
location: <35653..>36762
location: region:35653-36762:1
so has part: feature:35653-36762:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:35653-36762:1:exon

YGL248W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDE1
locus tag: YGL248W
EC number: 3.1.4.17
experiment: EXISTENCE:genetic interaction:GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity [PMID:2824992]
experiment: EXISTENCE:mutant phenotype:GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity [PMID:2824992|PMID:6300049]
experiment: EXISTENCE:mutant phenotype:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:9880329]
note: Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
codon start: 1
product: 3',5'-cyclic-nucleotide phosphodiesterase PDE1
translation: MVVFEITILGANGGPTEYGTQCFILKPARTEDPELIAVDGGAGMYQLREMLVQGRNENEGDDELVPSFYEHDREPIEFFIDSKLNIQKGLSKSLLQSLKRQGEHFESANTMKKTYEVFQGITDYYITHPHLDHISGLVVNSPSIYEQENSKKKTIWGLPHTIDVLQKHVFNDLIWPDLTAERSRKLKLKCLNPKEVQKCTIFPWDVIPFKVHHGIGVKTGAPVYSTFYIFRDRKSKDCIIVCGDVEQDRRESEESLLEEFWSYVAENIPLVHLKGILVECSCPLSSKPEQLYGHLSPIYLINELSNLNTLYNSSKGLSGLNVIVTHVKSTPAKRDPRLTILEELRFLAEERNLGDLRISIALEGHTLFL
SIO_010081: YGL248W
subclass of: SO_0000673
so part of: YGL248W
location: 35653..36762
location: region:35653-36762:1
so has part: feature:35653-36762:1:exon

NP_011266.1
type: Protein
SIO_000068: ncbiprotein

S000003217
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:35653-36762:1:exon

YGL247W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRR6
locus tag: YGL247W
so part of: sequence
location: <36933..>37526
location: region:36933-37526:1
so has part: feature:36933-37526:1:exon
subclass of: SO_0000010

852645
type: Gene
SIO_000068: ncbigene

position:36933:1
position: 36933
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:37526:1
position: 37526
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36933-37526:1:exon

YGL247W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRR6
locus tag: YGL247W
product: Brr6p
transcript id: NM_001181113.1
SIO_010081: YGL247W
subclass of: SO_0000673
so part of: YGL247W
location: <36933..>37526
location: region:36933-37526:1
so has part: feature:36933-37526:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:36933-37526:1:exon

YGL247W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRR6
locus tag: YGL247W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:30133335]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11483521|PMID:26432634]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:20016074|PMID:26432634]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:30133335]
experiment: EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:20016074]
experiment: EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:26432634|PMID:20016074]
note: Essential nuclear envelope integral membrane protein; interacts with chromatin, helping to maintain normal chromatin architecture and transcriptional regulation of certain loci at the nuclear envelope; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; homologous to Brl1p
codon start: 1
product: Brr6p
translation: MELRSFSRQPDGILANPRLGREEVLEGEHPQDARLARQSIWLSPSLIAEYIQLFFNFIIGTIGLSLAIKFILMIRNDVNLKLEHNVREELDKIATCKSRYFENQCEPHMRVPALEVRCNEWSKCMNKEIVSGSDYQWAKAWARTLAEVINAFFEAFSIRSFLFILISIIGIIFVTNTSFGSYRVYLNNKDTKSVRHA
SIO_010081: YGL247W
subclass of: SO_0000673
so part of: YGL247W
location: 36933..37526
location: region:36933-37526:1
so has part: feature:36933-37526:1:exon

NP_011267.1
type: Protein
SIO_000068: ncbiprotein

S000003216
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36933-37526:1:exon

YGL246C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAI1
locus tag: YGL246C
so part of: sequence
location: complement(<37617..>38780)
location: region:37617-38780:-1
so has part: feature:37617-38780:-1:exon
subclass of: SO_0000010

852646
type: Gene
SIO_000068: ncbigene

position:37617:-1
position: 37617
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:38780:-1
position: 38780
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:37617-38780:-1:exon

YGL246C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAI1
locus tag: YGL246C
product: decapping nuclease
transcript id: NM_001181112.1
SIO_010081: YGL246C
subclass of: SO_0000673
so part of: YGL246C
location: complement(<37617..>38780)
location: region:37617-38780:-1
so has part: feature:37617-38780:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:37617-38780:-1:exon

YGL246C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAI1
locus tag: YGL246C
experiment: EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12612077|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10805743]
experiment: EXISTENCE:direct assay:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:20802481]
experiment: EXISTENCE:direct assay:GO:0034353 mRNA 5'-diphosphatase activity [PMID:20802481]
experiment: EXISTENCE:direct assay:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:20802481]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10805743]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10805743]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:20802481]
experiment: EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15565157]
experiment: EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16131592]
experiment: EXISTENCE:mutant phenotype:GO:0110155 NAD-cap decapping [PMID:33139726]
experiment: EXISTENCE:mutant phenotype:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:20802481]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10805743]
note: Nuclear decapping endonuclease; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; involved in an early step of decapping non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs), part of ncRNA surveillance; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z
codon start: 1
product: decapping nuclease
translation: MGVSANLFVKQRGSTTALKQPKEIGFYSRTKDEEYLISDDTNLNYYYLPDAELDRKLDLSSGFQKFKDYYKDFEDRCSLRGLLETIESSERHKGKKINADIITFRGIARKLISCAFDSPSFNTVDLRIVSFNGQLFIKEVPEAVNAAKASSATEAGRNINQDLNVFTGYKFETLATLSNPLQYTPREVIEKRTKRIVSHGDEYISVVRTGVGNCKLILGAEVDCIFDFKENGRDNLKHYAELKCTQQVANISDTHKFERKLFRTWLQCFLVGIPRIIYGFKDDHYVLKTVEEFSTEEVPVLLKNNNPQVGSACLEAIKWYGLLTEWLLKMIPRDEDPHSQIRAFKLVFENNHLRLSEIEESDEEYSGLIDGEHILSNGFKEWRKSLK
SIO_010081: YGL246C
subclass of: SO_0000673
so part of: YGL246C
location: complement(37617..38780)
location: region:37617-38780:-1
so has part: feature:37617-38780:-1:exon

NP_011268.1
type: Protein
SIO_000068: ncbiprotein

S000003215
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:37617-38780:-1:exon

YGL245W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GSN1
gene: GUS1
locus tag: YGL245W
gene synonym: GSN1
so part of: sequence
location: <39023..>41149
location: region:39023-41149:1
so has part: feature:39023-41149:1:exon
subclass of: SO_0000010

852606
type: Gene
SIO_000068: ncbigene

position:39023:1
position: 39023
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:41149:1
position: 41149
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:39023-41149:1:exon

YGL245W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GSN1
gene: GUS1
locus tag: YGL245W
gene synonym: GSN1
product: glutamate--tRNA ligase GUS1
transcript id: NM_001181111.1
SIO_010081: YGL245W
subclass of: SO_0000673
so part of: YGL245W
location: <39023..>41149
location: region:39023-41149:1
so has part: feature:39023-41149:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:39023-41149:1:exon

YGL245W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GSN1
gene: GUS1
locus tag: YGL245W
gene synonym: GSN1
EC number: 6.1.1.17
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004818 glutamate-tRNA ligase activity [PMID:11069915]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19417106]
experiment: EXISTENCE:direct assay:GO:0006424 glutamyl-tRNA aminoacylation [PMID:11069915]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:26359986]
experiment: EXISTENCE:direct assay:GO:0017102 methionyl glutamyl tRNA synthetase complex [PMID:11069915]
note: Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
codon start: 1
product: glutamate--tRNA ligase GUS1
translation: MPSTLTINGKAPIVAYAELIAARIVNALAPNSIAIKLVDDKKAPAAKLDDATEDVFNKITSKFAAIFDNGDKEQVAKWVNLAQKELVIKNFAKLSQSLETLDSQLNLRTFILGGLKYSAADVACWGALRSNGMCGSIIKNKVDVNVSRWYTLLEMDPIFGEAHDFLSKSLLELKKSANVGKKKETHKANFEIDLPDAKMGEVVTRFPPEPSGYLHIGHAKAALLNQYFAQAYKGKLIIRFDDTNPSKEKEEFQDSILEDLDLLGIKGDRITYSSDYFQEMYDYCVQMIKDGKAYCDDTPTEKMREERMDGVASARRDRSVEENLRIFTEEMKNGTEEGLKNCVRAKIDYKALNKTLRDPVIYRCNLTPHHRTGSTWKIYPTYDFCVPIVDAIEGVTHALRTIEYRDRNAQYDWMLQALRLRKVHIWDFARINFVRTLLSKRKLQWMVDKDLVGNWDDPRFPTVRGVRRRGMTVEGLRNFVLSQGPSRNVINLEWNLIWAFNKKVIDPIAPRHTAIVNPVKIHLEGSEAPQEPKIEMKPKHKKNPAVGEKKVIYYKDIVVDKDDADVINVDEEVTLMDWGNVIITKKNDDGSMVAKLNLEGDFKKTKHKLTWLADTKDVVPVDLVDFDHLITKDRLEEDESFEDFLTPQTEFHTDAIADLNVKDMKIGDIIQFERKGYYRLDALPKDGKPYVFFTIPDGKSVNKYGAKK
SIO_010081: YGL245W
subclass of: SO_0000673
so part of: YGL245W
location: 39023..41149
location: region:39023-41149:1
so has part: feature:39023-41149:1:exon

NP_011269.2
type: Protein
SIO_000068: ncbiprotein

S000003214
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:39023-41149:1:exon

YGL244W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSL3
gene: RTF1
locus tag: YGL244W
gene synonym: CSL3
so part of: sequence
location: <41498..>43174
location: region:41498-43174:1
so has part: feature:41498-43174:1:exon
subclass of: SO_0000010

852607
type: Gene
SIO_000068: ncbigene

position:41498:1
position: 41498
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:43174:1
position: 43174
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:41498-43174:1:exon

YGL244W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSL3
gene: RTF1
locus tag: YGL244W
gene synonym: CSL3
product: Rtf1p
transcript id: NM_001181110.1
SIO_010081: YGL244W
subclass of: SO_0000673
so part of: YGL244W
location: <41498..>43174
location: region:41498-43174:1
so has part: feature:41498-43174:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:41498-43174:1:exon

YGL244W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSL3
gene: RTF1
locus tag: YGL244W
gene synonym: CSL3
experiment: EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:12682017]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20732871]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643076]
experiment: EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]
experiment: EXISTENCE:direct assay:GO:2001173 regulation of histone H2B conserved C-terminal lysine ubiquitination [PMID:19531475]
experiment: EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11884586]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11927560]
experiment: EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15180994]
experiment: EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]
experiment: EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:11927560]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]
experiment: EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:16246725]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]
experiment: EXISTENCE:mutant phenotype:GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [PMID:18469135]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:32290544]
experiment: EXISTENCE:mutant phenotype:GO:0051569 regulation of histone H3-K4 methylation [PMID:12667454|PMID:12876293|PMID:12876294|PMID:15180994]
experiment: EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21737840]
experiment: EXISTENCE:mutant phenotype:GO:2001160 regulation of histone H3-K79 methylation [PMID:12876293]
experiment: EXISTENCE:mutant phenotype:GO:2001163 regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [PMID:15149594]
experiment: EXISTENCE:mutant phenotype:GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [PMID:18469135]
experiment: EXISTENCE:mutant phenotype:GO:2001166 regulation of histone H2B ubiquitination [PMID:12876293|PMID:12876294]
experiment: EXISTENCE:mutant phenotype:GO:2001173 regulation of histone H2B conserved C-terminal lysine ubiquitination [PMID:17576814]
experiment: EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11884586|PMID:11927560]
note: Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
codon start: 1
product: Rtf1p
translation: MSDLDEDLLALAGADESEEEDQVLTTTSAKRAKNNDQSLSKKRRIEVGSVEDDDEEDDYNPYSVGNADYGSEEEEEANPFPLEGKYKDESDREHLESLPEMERETLLFERSQIMQKYQERKLFRARGRDMKEQQQRAKNDEDSRKTRASTRSTHATGHSDIKASKLSQLKKQRARKNRHYSDNEDEDDEEDYREEDYKDDEGSEYGDDEEYNPFDRRDTYDKREEVEWAEEEDEQDREPEISDFNKLRIGRSFVAKFCFYPGFEDAVKGCYGRVNVGTDKRTGKTSYRMVRIERVFLQKPYNMGKFYTNQYFGVTQGKDRKVFQMNYFSDGLFAEDEYQRYLRALDNSQMIKPSLHSLSNKTKEVMDFVNTPLTDKTTDEVVRHRMQFNKKLSGTNAVLEKTVLREKLQYAKETNNEKDIAKYSAQLRNFEKRMSVYEKHHENDQSDIKKLGELTSKNRKLNMSNIRNAEHVKKEDSNNFDSKSDPFSRLKTRTKVYYQEIQKEENAKAKEIAQQEKLQEDKDAKDKREKELLVAQFRRLGGLERMVGELDIKFDLKF
SIO_010081: YGL244W
subclass of: SO_0000673
so part of: YGL244W
location: 41498..43174
location: region:41498-43174:1
so has part: feature:41498-43174:1:exon

NP_011270.1
type: Protein
SIO_000068: ncbiprotein

S000003213
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:41498-43174:1:exon

YGL243W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TAD1
locus tag: YGL243W
so part of: sequence
location: <43307..>44509
location: region:43307-44509:1
so has part: feature:43307-44509:1:exon
subclass of: SO_0000010

852608
type: Gene
SIO_000068: ncbigene

position:43307:1
position: 43307
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:44509:1
position: 44509
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:43307-44509:1:exon

YGL243W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TAD1
locus tag: YGL243W
product: tRNA-specific adenosine deaminase
transcript id: NM_001181109.1
SIO_010081: YGL243W
subclass of: SO_0000673
so part of: YGL243W
location: <43307..>44509
location: region:43307-44509:1
so has part: feature:43307-44509:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:43307-44509:1:exon

YGL243W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TAD1
locus tag: YGL243W
EC number: 3.5.4.34
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:9707437]
experiment: EXISTENCE:direct assay:GO:0043829 tRNA-specific adenosine-37 deaminase activity [PMID:9707437]
note: tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala
codon start: 1
product: tRNA-specific adenosine deaminase
translation: MVSCQGTRPCIVNLLTMPSEDKLGEEISTRVINEYSKLKSACRPIIRPSGIREWTILAGVAAINRDGGANKIEILSIATGVKALPDSELQRSEGKILHDCHAEILALRGANTVLLNRIQNYNPSSGDKFIQHNDEIPARFNLKENWELALYISRLPCGDASMSFLNDNCKNDDFIKIEDSDEFQYVDRSVKTILRGRLNFNRRNVVRTKPGRYDSNITLSKSCSDKLLMKQRSSVLNCLNYELFEKPVFLKYIVIPNLEDETKHHLEQSFHTRLPNLDNEIKFLNCLKPFYDDKLDEEDVPGLMCSVKLFMDDFSTEEAILNGVRNGFYTKSSKPLRKHCQSQVSRFAQWELFKKIRPEYEGISYLEFKSRQKKRSQLIIAIKNILSPDGWIPTRTDDVK
SIO_010081: YGL243W
subclass of: SO_0000673
so part of: YGL243W
location: 43307..44509
location: region:43307-44509:1
so has part: feature:43307-44509:1:exon

NP_011271.1
type: Protein
SIO_000068: ncbiprotein

S000003212
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:43307-44509:1:exon

YGL242C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL242C
so part of: sequence
location: complement(<44652..>45197)
location: region:44652-45197:-1
so has part: feature:44652-45197:-1:exon
subclass of: SO_0000010

852609
type: Gene
SIO_000068: ncbigene

position:44652:-1
position: 44652
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45197:-1
position: 45197
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:44652-45197:-1:exon

YGL242C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL242C
product: uncharacterized protein
transcript id: NM_001181108.1
SIO_010081: YGL242C
subclass of: SO_0000673
so part of: YGL242C
location: complement(<44652..>45197)
location: region:44652-45197:-1
so has part: feature:44652-45197:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:44652-45197:-1:exon

YGL242C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL242C
note: hypothetical protein; N-terminally propionylated in vivo; deletion mutant is viable
codon start: 1
product: uncharacterized protein
translation: MNTEGASLSEQLLDAARRNNLDLLETVFDSLDNDPEKIAKLINESKEPLGNTALHLCCKYGSWEVLDKILDQDGEIEIDPQNDVDGDTPLHVTVRYSQEEPEHGTFIARNLIEVGADPRVRNYNNQKPVDLVHGDELDELIDLLQGAELAIDSTNGSGDNNEDGEMIDDGPSDDDEEDDKK
SIO_010081: YGL242C
subclass of: SO_0000673
so part of: YGL242C
location: complement(44652..45197)
location: region:44652-45197:-1
so has part: feature:44652-45197:-1:exon

NP_011272.1
type: Protein
SIO_000068: ncbiprotein

S000003211
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:44652-45197:-1:exon

YGL241W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KAP114
locus tag: YGL241W
so part of: sequence
location: <45445..>48459
location: region:45445-48459:1
so has part: feature:45445-48459:1:exon
subclass of: SO_0000010

852610
type: Gene
SIO_000068: ncbigene

position:45445:1
position: 45445
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48459:1
position: 48459
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45445-48459:1:exon

YGL241W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KAP114
locus tag: YGL241W
product: Kap114p
transcript id: NM_001181107.1
SIO_010081: YGL241W
subclass of: SO_0000673
so part of: YGL241W
location: <45445..>48459
location: region:45445-48459:1
so has part: feature:45445-48459:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45445-48459:1:exon

YGL241W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KAP114
locus tag: YGL241W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10385521|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10385521|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:15888545]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:15888545|PMID:10385521]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:12456659]
experiment: EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:10385521]
experiment: EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:10385521]
note: Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress
codon start: 1
product: Kap114p
translation: MDINELIIGAQSADKHTREVAETQLLQWCDSDASQVFKALANVALQHEASLESRQFALLSLRKLITMYWSPGFESYRSTSNVEIDVKDFIREVLLKLCLNDNENTKIKNGASYCIVQISAVDFPDQWPQLLTVIYDAISHQHSLNAMSLLNEIYDDVVSEEMFFEGGIGLATMEIVFKVLNTETSTLIAKIAALKLLKACLLQMSSHNEYDEASRKSFVSQCLATSLQILGQLLTLNFGNVDVISQLKFKSIIYENLVFIKNDFSRKHFSSELQKQFKIMAIQDLENVTHINANVETTESEPLLETVHDCSIYIVEFLTSVCTLQFSVEEMNKIITSLTILCQLSSETREIWTSDFNTFVSKETGLAASYNVRDQANEFFTSLPNPQLSLIFKVVSNDIEHSTCNYSTLESLLYLLQCILLNDDEITGENIDQSLQILIKTLENILVSQEIPELILARAILTIPRVLDKFIDALPDIKPLTSAFLAKSLNLALKSDKELIKSATLIAFTYYCYFAELDSVLGPEVCSETQEKVIRIINQVSSDAEEDTNGALMEVLSQVISYNPKEPHSRKEILQAEFHLVFTISSEDPANVQVVVQSQECLEKLLDNINMDNYKNYIELCLPSFINVLDSNNANNYRYSPLLSLVLEFITVFLKKKPNDGFLPDEINQYLFEPLAKVLAFSTEDETLQLATEAFSYLIFNTDTRAMEPRLMDIMKVLERLLSLEVSDSAAMNVGPLVVAIFTRFSKEIQPLIGRILEAVVVRLIKTQNISTEQNLLSVLCFLTCNDPKQTVDFLSSFQIDNTDALTLVMRKWIEAFEVIRGEKRIKENIVALSNLFFLNDKRLQKVVVNGNLIPYEGDLIITRSMAKKMPDRYVQVPLYTKIIKLFVSELSFQSKQPNPEQLITSDIKQEVVNANKDDDNDDWEDVDDVLDYDKLKEYIDDDVDEEADDDSDDITGLMDVKESVVQLLVRFFKEVASKDVSGFHCIYETLSDSERKVLSEALL
SIO_010081: YGL241W
subclass of: SO_0000673
so part of: YGL241W
location: 45445..48459
location: region:45445-48459:1
so has part: feature:45445-48459:1:exon

NP_011273.1
type: Protein
SIO_000068: ncbiprotein

S000003210
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45445-48459:1:exon

YGL240W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APC10
gene: DOC1
locus tag: YGL240W
gene synonym: APC10
so part of: sequence
location: <48613..>49365
location: region:48613-49365:1
so has part: feature:48613-49365:1:exon
subclass of: SO_0000010

852611
type: Gene
SIO_000068: ncbigene

position:48613:1
position: 48613
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:49365:1
position: 49365
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48613-49365:1:exon

YGL240W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APC10
gene: DOC1
locus tag: YGL240W
gene synonym: APC10
product: anaphase promoting complex subunit DOC1
transcript id: NM_001181106.1
SIO_010081: YGL240W
subclass of: SO_0000673
so part of: YGL240W
location: <48613..>49365
location: region:48613-49365:1
so has part: feature:48613-49365:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48613-49365:1:exon

YGL240W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APC10
gene: DOC1
locus tag: YGL240W
gene synonym: APC10
experiment: EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:12402045]
experiment: EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:12402045]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:12402045]
experiment: EXISTENCE:direct assay:GO:1904668 positive regulation of ubiquitin protein ligase activity [PMID:12402045]
experiment: EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:12399376]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:9348530|PMID:12402045]
experiment: EXISTENCE:mutant phenotype:GO:1904668 positive regulation of ubiquitin protein ligase activity [PMID:12402045]
note: Processivity factor; required for ubiquitination activity of anaphase promoting complex (APC), mediates the activity of APC by contributing to substrate recognition; involved in cyclin proteolysis; contains conserved DOC1 homology domain
codon start: 1
product: anaphase promoting complex subunit DOC1
translation: MDPIGINKVLDHLAPSELIKPVKSCHNKPSVLVLDDRIVDAATKDLYVNGFQEEIQYQNPTPENLQHMFHQGIEILDSARMINVTHLALWKPSSFKLGNPVDFALDDNYDTFWQSDGGQPHQLDIMFSKRMDICVMAIFFSMIADESYAPSLVKVYAGHSPSDARFYKMLEVRNVNGWVALRFLDNREDDQLLKCQFIRLLFPVNHENGKDTHLRGIRLYVPSNEPHQDTHEWAQTLPETNNVFQDAILR
SIO_010081: YGL240W
subclass of: SO_0000673
so part of: YGL240W
location: 48613..49365
location: region:48613-49365:1
so has part: feature:48613-49365:1:exon

NP_011274.2
type: Protein
SIO_000068: ncbiprotein

S000003209
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48613-49365:1:exon

YGL238W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KAP109
gene: CSE1
locus tag: YGL238W
gene synonym: KAP109
so part of: sequence
location: <49552..>52434
location: region:49552-52434:1
so has part: feature:49552-52434:1:exon
subclass of: SO_0000010

852612
type: Gene
SIO_000068: ncbigene

position:49552:1
position: 49552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:52434:1
position: 52434
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:49552-52434:1:exon

YGL238W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KAP109
gene: CSE1
locus tag: YGL238W
gene synonym: KAP109
product: importin-alpha export receptor
transcript id: NM_001181104.1
SIO_010081: YGL238W
subclass of: SO_0000673
so part of: YGL238W
location: <49552..>52434
location: region:49552-52434:1
so has part: feature:49552-52434:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:49552-52434:1:exon

YGL238W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KAP109
gene: CSE1
locus tag: YGL238W
gene synonym: KAP109
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:9857050]
experiment: EXISTENCE:genetic interaction:GO:0005049 nuclear export signal receptor activity [PMID:9857050]
experiment: EXISTENCE:genetic interaction:GO:0006611 protein export from nucleus [PMID:9857050]
experiment: EXISTENCE:mutant phenotype:GO:0061015 snRNA import into nucleus [PMID:31189105]
experiment: EXISTENCE:physical interaction:GO:0005049 nuclear export signal receptor activity [PMID:9857050]
experiment: EXISTENCE:physical interaction:GO:0006611 protein export from nucleus [PMID:9857050]
note: Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression
codon start: 1
product: importin-alpha export receptor
translation: MSDLETVAKFLAESVIASTAKTSERNLRQLETQDGFGLTLLHVIASTNLPLSTRLAGALFFKNFIKRKWVDENGNHLLPANNVELIKKEIVPLMISLPNNLQVQIGEAISSIADSDFPDRWPTLLSDLASRLSNDDMVTNKGVLTVAHSIFKRWRPLFRSDELFLEIKLVLDVFTAPFLNLLKTVDEQITANENNKASLNILFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYLSYSNPLLEDPDETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSISNQPKYDILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIILPNVTLREEDVELFEDDPIEYIRRDLEGSDTDTRRRACTDFLKELKEKNEVLVTNIFLAHMKGFVDQYMSDPSKNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLNVVDFFTKEIAPDLTSNNIPHIILRVDAIKYIYTFRNQLTKAQLIELMPILATFLQTDEYVVYTYAAITIEKILTIRESNTSPAFIFHKEDISNSTEILLKNLIALILKHGSSPEKLAENEFLMRSIFRVLQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPRFTHYTFESIGAILNYTQRQNLPLLVDSMMPTFLTVFSEDIQEFIPYVFQIIAFVVEQSATIPESIKPLAQPLLAPNVWELKGNIPAVTRLLKSFIKTDSSIFPDLVPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAVLLLQRLQNSKTERYVKKLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIWGNFIITTLPTIGNLLDRKIALIGVLNMVINGQFFQSKYPTLISSTMNSIIETASSQSIANLKNDYVDLDNLEEISTFGSHFSKLVSISEKPFDPLPEIDVNNGVRLYVAEALNKYNAISGNTFLNTILPQLTQENQVKLNQLLVGN
SIO_010081: YGL238W
subclass of: SO_0000673
so part of: YGL238W
location: 49552..52434
location: region:49552-52434:1
so has part: feature:49552-52434:1:exon

NP_011276.1
type: Protein
SIO_000068: ncbiprotein

S000003207
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:49552-52434:1:exon

YGL237C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HAP2
locus tag: YGL237C
so part of: sequence
location: complement(<52731..>53528)
location: region:52731-53528:-1
so has part: feature:52731-53528:-1:exon
subclass of: SO_0000010

852614
type: Gene
SIO_000068: ncbigene

position:52731:-1
position: 52731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:53528:-1
position: 53528
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52731-53528:-1:exon

YGL237C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HAP2
locus tag: YGL237C
product: transcription activator HAP2
transcript id: NM_001181103.1
SIO_010081: YGL237C
subclass of: SO_0000673
so part of: YGL237C
location: complement(<52731..>53528)
location: region:52731-53528:-1
so has part: feature:52731-53528:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:52731-53528:-1:exon

YGL237C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HAP2
locus tag: YGL237C
experiment: EXISTENCE:direct assay:GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter [PMID:2832951]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7828851]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2832951]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:2832951]
experiment: EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2182199]
experiment: EXISTENCE:physical interaction:GO:0016602 CCAAT-binding factor complex [PMID:2832951]
note: Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA
codon start: 1
product: transcription activator HAP2
translation: MSADETDAKFHPLETDLQSDTAAATSTAAASRSPSLQEKPIEMPLDMGKAPSPRGEDQRVTNEEDLFLFNRLRASQNRVMDSLEPQQQSQYTSSSVSTMEPSADFTSFSAVTTLPPPPHQQQQQQQQQQQQQQLVVQAQYTQNQPNLQSDVLGTAIAEQPFYVNAKQYYRILKRRYARAKLEEKLRISRERKPYLHESRHKHAMRRPRGEGGRFLTAAEIKAMKSKKSGASDDPDDSHEDKKITTKIIQEQPHATSTAAAADKKT
SIO_010081: YGL237C
subclass of: SO_0000673
so part of: YGL237C
location: complement(52731..53528)
location: region:52731-53528:-1
so has part: feature:52731-53528:-1:exon

NP_011277.1
type: Protein
SIO_000068: ncbiprotein

S000003206
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52731-53528:-1:exon

YGL236C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IPS1
gene: MTO1
locus tag: YGL236C
gene synonym: IPS1
so part of: sequence
location: complement(<53787..>55796)
location: region:53787-55796:-1
so has part: feature:53787-55796:-1:exon
subclass of: SO_0000010

852616
type: Gene
SIO_000068: ncbigene

position:53787:-1
position: 53787
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55796:-1
position: 55796
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53787-55796:-1:exon

YGL236C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IPS1
gene: MTO1
locus tag: YGL236C
gene synonym: IPS1
product: tRNA modification protein MTO1
transcript id: NM_001181102.1
SIO_010081: YGL236C
subclass of: SO_0000673
so part of: YGL236C
location: complement(<53787..>55796)
location: region:53787-55796:-1
so has part: feature:53787-55796:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53787-55796:-1:exon

YGL236C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IPS1
gene: MTO1
locus tag: YGL236C
gene synonym: IPS1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9774408|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0070899 mitochondrial tRNA wobble uridine modification [PMID:15509579]
note: Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant
codon start: 1
product: tRNA modification protein MTO1
translation: MLRVTTLASSCTSFPLQVLRRRLTISSLTSFQPTTKTQVVVIGAGHAGCEAAAASSRTGAHTTLITPSLTDIGKCSCNPSIGGVGKGILVKEIDALDGLMGKVTDLAGVQFKMLNRSKGPAVWGPRAQIDRELYKKYMQRELSDKKAHPNLSLLQNKVADLILYDPGCGHKVIKGVVLDDGTQVGADQVIITTGTFLSAEIHIGDKRIAAGRIGEQPTYGISNTLQNEVGFQLGRLKTGTPARLAKESIDFSALEVQKGDALPVPMSFLNETVSVEPTKQLDCFGTHTTPQMHDFLRNNLHQSIHIQDTTIKGPRYCPSIEAKILRFPDRSSHKIWLEPEGFNSDVIYPNGISNSMPEDVQLQMMRLIPGMANVEILQPAYGVEYDYVDPRQLKPSLETKLVDGLFLAGQINGTTGYEEAAAQGIIAGINAGLLSRQEREQLVLKRSEAYIGVLIDDLINNGVIEPYRMFTSRSEFRISVRADNADFRLTPIGAQLGIISPVRLSQYSRDKHLYDETIRALQNFKLSSQKWSSLLQANIAPQAENRSAWEIFRFKDMDLHKLYECIPDLPINLLDIPMHVVTKINIQGKYEPYIVKQNQFVKAFQADENMLLPQDYDYRQLPTLSTECKLLLNRVQPLTIGQARRIQGITAAALFELYRVARKPSQPVM
SIO_010081: YGL236C
subclass of: SO_0000673
so part of: YGL236C
location: complement(53787..55796)
location: region:53787-55796:-1
so has part: feature:53787-55796:-1:exon

NP_011278.2
type: Protein
SIO_000068: ncbiprotein

S000003205
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53787-55796:-1:exon

YGL235W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL235W
so part of: sequence
location: <55279..>55815
location: region:55279-55815:1
so has part: feature:55279-55815:1:exon
subclass of: SO_0000010

852615
type: Gene
SIO_000068: ncbigene

position:55279:1
position: 55279
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:55815:1
position: 55815
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:55279-55815:1:exon

YGL235W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL235W
product: uncharacterized protein
transcript id: NM_001181101.1
SIO_010081: YGL235W
subclass of: SO_0000673
so part of: YGL235W
location: <55279..>55815
location: region:55279-55815:1
so has part: feature:55279-55815:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:55279-55815:1:exon

YGL235W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL235W
note: hypothetical protein; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
codon start: 1
product: uncharacterized protein
translation: MTLWPHPGSYKIKSATLFCSRDKLGCAFLSESSLCMYFLYNSLSIWALGPHTAGPLLLFSILNCTPARSVTLPISPSRASISFTRMPLPTPPIEGLHEHLPISVNDGVMRVVCAPVLDDAAAASQPACPAPMTTTCVLVVGWKLVKEDMVNRLLRTCKGNEVHEDAKVVTRSIVLWGV
SIO_010081: YGL235W
subclass of: SO_0000673
so part of: YGL235W
location: 55279..55815
location: region:55279-55815:1
so has part: feature:55279-55815:1:exon

NP_011279.1
type: Protein
SIO_000068: ncbiprotein

S000003204
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:55279-55815:1:exon

YGL234W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADE57
locus tag: YGL234W
so part of: sequence
location: <56482..>58890
location: region:56482-58890:1
so has part: feature:56482-58890:1:exon
subclass of: SO_0000010

852617
type: Gene
SIO_000068: ncbigene

position:56482:1
position: 56482
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58890:1
position: 58890
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56482-58890:1:exon

YGL234W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADE57
locus tag: YGL234W
product: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
transcript id: NM_001181100.1
SIO_010081: YGL234W
subclass of: SO_0000673
so part of: YGL234W
location: <56482..>58890
location: region:56482-58890:1
so has part: feature:56482-58890:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56482-58890:1:exon

YGL234W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADE57
locus tag: YGL234W
EC number: 6.3.3.1
EC number: 6.3.4.13
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
note: Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) ['Ade5'] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) ['Ade7'] activities
codon start: 1
product: bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase
translation: MLNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPDVANFARLQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIPTASYDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGGMGAYAPAPVATPSLLKTIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLVPEVLEYNVRFGDPETQAVLSLLDDQTDLAQVFLAAAEHRLDSVNIGIDDTRSAVTVVVAAGGYPESYAKGDKITLDTDKLPPHTQIFQAGTKYDSATDSLLTNGGRVLSVTSTAQDLRTAVDTVYEAVKCVHFQNSYYRKDIAYRAFQNSESSKVAITYADSGVSVDNGNNLVQTIKEMVRSTRRPGADSDIGGFGGLFDLAQAGFRQNEDTLLVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMAAGDVLLGLASSGVHSNGFSLVRKIIQHVALPWDAPCPWDESKTLGEGILEPTKIYVKQLLPSIRQRLLLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKRENVKAVCDSLTEEGEIIWELGSLQERPKDAPGCVIENGTKLY
SIO_010081: YGL234W
subclass of: SO_0000673
so part of: YGL234W
location: 56482..58890
location: region:56482-58890:1
so has part: feature:56482-58890:1:exon

NP_011280.1
type: Protein
SIO_000068: ncbiprotein

S000003203
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56482-58890:1:exon

YGL233W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC15
locus tag: YGL233W
so part of: sequence
location: <59122..>61854
location: region:59122-61854:1
so has part: feature:59122-61854:1:exon
subclass of: SO_0000010

852618
type: Gene
SIO_000068: ncbigene

position:59122:1
position: 59122
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:61854:1
position: 61854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:59122-61854:1:exon

YGL233W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC15
locus tag: YGL233W
product: Rab GTPase-binding exocyst subunit SEC15
transcript id: NM_001181099.1
SIO_010081: YGL233W
subclass of: SO_0000673
so part of: YGL233W
location: <59122..>61854
location: region:59122-61854:1
so has part: feature:59122-61854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:59122-61854:1:exon

YGL233W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC15
locus tag: YGL233W
experiment: EXISTENCE:curator inference:GO:0090522 vesicle tethering involved in exocytosis [PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:16478783]
experiment: EXISTENCE:direct assay:GO:0000145 exocyst [PMID:1512289|PMID:7615633|PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:16478783]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:16478783|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10022848]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]
experiment: EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
note: Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
codon start: 1
product: Rab GTPase-binding exocyst subunit SEC15
translation: MDQEGQPLLSKDFQQVLLATASGNNSSWTERAVLNNESTDAVKHEPALGQNDVFDLDPLSFDKWVPFLRRALDKNQLDPVIDELENSIEDNFQGLELQLLQDSQMNDKLETSIDEIANIQGMVQDTLSSEISKFQIRLSESANELIVKKQMYVNNKKISLKISEATILITKVVRILELSSKCQELITERKFFKVLQNLDSLEKLYLQEFKNYNFQFLIEIYNSIPFLQKVTKDECINLIRNSLNLNLGKNLIKVGQEFVAIYENELLPQWLETRSKMKLTNFKFNSPIEISMRDESFLAKLNLGEFFQLDDFHDSIMIFQNLNELSVLSGEFNKEYELRKTKLMYPLIWKKNKTAAYQMDSLLRGTGTTPGSTAHDVSTDDPFTQSLSLHFLQDYFLKILGFLLYDINLNKATEFILVDNNYNSTNEFWDGLMDRLSPYLSYFIDEKLKTEEDMIKLKDFLCIYVAILENFKLNIEPLYKILVSIFEKFCSVSLRAFDDEFQILLNDDDFMPLSINDKTLYEKVLKICWMKEGEHLSLPDPTNGEPFAVTLPFSPLYPMTCTLAKKTYSKITAFLSIFYRHELHTLNNILVKTMDDIFNDIVNKKIRSKLESTSREEIAQILVNLDYFIIAAKEFSNFMTRENILQNPDMEIRLSSIKYLAESRKLAETKLIELIDSKISDILETIEIDWQITEVRQDPDISIIDLAQFLEMMFASTLQNLPYSVQTLLIFREFDSLTRQFMGLLLHDTPSTITHESIMNFEVDVNYLESIIPRIFPSTPGTIDSNGYQSPMTPSTPTFPNANGVDAPTLFENNIKSLEATFMELKQCIELLKTQGKDYNEPEIRLRKYSRIRQEDAALLLSKIQHFVSSVEGANGDDTSVMDSSSIFNSESASVIDSNTSRIAKFFNRR
SIO_010081: YGL233W
subclass of: SO_0000673
so part of: YGL233W
location: 59122..61854
location: region:59122-61854:1
so has part: feature:59122-61854:1:exon

NP_011281.1
type: Protein
SIO_000068: ncbiprotein

S000003202
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:59122-61854:1:exon

YGL232W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TAN1
locus tag: YGL232W
so part of: sequence
location: <62075..>63002
location: region:62075-63002:1
so has part: feature:62075-63002:1:exon
subclass of: SO_0000010

852619
type: Gene
SIO_000068: ncbigene

position:62075:1
position: 62075
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:63002:1
position: 63002
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62075-63002:1:exon

YGL232W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TAN1
locus tag: YGL232W
product: putative tRNA acetyltransferase
transcript id: NM_001181098.1
SIO_010081: YGL232W
subclass of: SO_0000673
so part of: YGL232W
location: join(<62075..62131,62190..>63002)
location: region:62075-63002:1
so has part: feature:62075-62131:1:exon
so has part: feature:62190-63002:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:62075-62131:1:exon

position:62131:1
position: 62131
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:62190-63002:1:exon

position:62190:1
position: 62190
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL232W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TAN1
locus tag: YGL232W
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15037780]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:15037780]
note: Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
codon start: 1
product: putative tRNA acetyltransferase
translation: MGEKRNRNGKDANSQNRKKFKVSSGFLDPGTSGIYATCSRRHERQAAQELQLLFEEKFQELYGDIKEGEDESENDEKKDLSIEDQIKKELQELKGEETGKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPITYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFNTIERMDIINQVVKLVNKEGSEFNHTVDLKNYDKLILVECFKSNIGMCVVDGDYKTKYRKYNVQQLYESKFRKDEDKSVKQ
SIO_010081: YGL232W
subclass of: SO_0000673
so part of: YGL232W
location: join(62075..62131,62190..63002)
location: region:62075-63002:1
so has part: feature:62075-62131:1:exon
so has part: feature:62190-63002:1:exon

NP_011282.1
type: Protein
SIO_000068: ncbiprotein

S000003201
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:62075-62131:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:62190-63002:1:exon

YGL231C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMC4
locus tag: YGL231C
so part of: sequence
location: complement(<63048..>63620)
location: region:63048-63620:-1
so has part: feature:63048-63620:-1:exon
subclass of: SO_0000010

852620
type: Gene
SIO_000068: ncbigene

position:63048:-1
position: 63048
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:63620:-1
position: 63620
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:63048-63620:-1:exon

YGL231C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMC4
locus tag: YGL231C
product: chaperone EMC4
transcript id: NM_001181097.1
SIO_010081: YGL231C
subclass of: SO_0000673
so part of: YGL231C
location: complement(<63048..>63620)
location: region:63048-63620:-1
so has part: feature:63048-63620:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:63048-63620:-1:exon

YGL231C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMC4
locus tag: YGL231C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]
experiment: EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]
note: Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4
codon start: 1
product: chaperone EMC4
translation: MSEQEPYEWAKHLLDTKYIEKYNIQNSNTLPSPPGFEGNSSKGNVTRKQQDATSQTTSLAQKNQITVLQVQKAWQIALQPAKSIPMNIFMSYMSGTSLQIIPIMTALMLLSGPIKAIFSTRSAFKPVLGNKATQSQVQTAMFMYIVFQGVLMYIGYRKLNSMGLIPNAKGDWLPWERIAHYNNGLQWFSD
SIO_010081: YGL231C
subclass of: SO_0000673
so part of: YGL231C
location: complement(63048..63620)
location: region:63048-63620:-1
so has part: feature:63048-63620:-1:exon

NP_011283.1
type: Protein
SIO_000068: ncbiprotein

S000003200
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:63048-63620:-1:exon

YGL230C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL230C
so part of: sequence
location: complement(<63772..>64215)
location: region:63772-64215:-1
so has part: feature:63772-64215:-1:exon
subclass of: SO_0000010

852621
type: Gene
SIO_000068: ncbigene

position:63772:-1
position: 63772
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:64215:-1
position: 64215
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:63772-64215:-1:exon

YGL230C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL230C
product: uncharacterized protein
transcript id: NM_001181096.1
SIO_010081: YGL230C
subclass of: SO_0000673
so part of: YGL230C
location: complement(<63772..>64215)
location: region:63772-64215:-1
so has part: feature:63772-64215:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:63772-64215:-1:exon

YGL230C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL230C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; non-essential gene
codon start: 1
product: uncharacterized protein
translation: MGIITLSGNVLHLLKAYPKKGLEEVSQPEPNTANDSSTEYKGKSKDDFQMVEKSNTDERYNFTRTKKWFLLMTSEYYKLMENRLLMFCIIACSFICAIQFLFFIIYWTNIVPRKTQRAITNLNYDYLTAHLKEQCVPYAKILDQCIL
SIO_010081: YGL230C
subclass of: SO_0000673
so part of: YGL230C
location: complement(63772..64215)
location: region:63772-64215:-1
so has part: feature:63772-64215:-1:exon

NP_011284.1
type: Protein
SIO_000068: ncbiprotein

S000003199
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:63772-64215:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS702; Autonomously Replicating Sequence
so part of: sequence
location: 64360..64464
location: region:64360-64464:1
so has part: feature:64360-64464:1:region

S000118451
type: SGD
SIO_000068: sgd

position:64360:1
position: 64360
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:64464:1
position: 64464
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64360-64464:1:region

YGL229C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SAP4
locus tag: YGL229C
so part of: sequence
location: complement(<64503..>66959)
location: region:64503-66959:-1
so has part: feature:64503-66959:-1:exon
subclass of: SO_0000010

852622
type: Gene
SIO_000068: ncbigene

position:64503:-1
position: 64503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:66959:-1
position: 66959
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64503-66959:-1:exon

YGL229C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SAP4
locus tag: YGL229C
product: Sap4p
transcript id: NM_001181095.1
SIO_010081: YGL229C
subclass of: SO_0000673
so part of: YGL229C
location: complement(<64503..>66959)
location: region:64503-66959:-1
so has part: feature:64503-66959:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:64503-66959:-1:exon

YGL229C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SAP4
locus tag: YGL229C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]
note: Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication
codon start: 1
product: Sap4p
translation: MSLWPFGETLSHSGIDSILEEYYLIFRSLEGNETSSTDDKKNEPSMESESEFGTESRDRSDLNQSFIDRILLETALLDELNGAANDRLVDFICLGYFYDDRSQQVRHMDYLVDMLMAYLKDIDRTGYRTPFLLENSFHQTGEYEDQDDEDPMLYVNIISSIFCSKSAPIVEALVQNTPFLSSLFEVFQFENIEAENCPILAVFLKINETLLFEQTSSYLEFFKSQPNIVDKFLYHIEVSPLVEFLIKIMLTDQVESPTNIIDFLYHQDLIPKCLNLLENSKYSPGIQNSSGELLKALISISTNFKLDTLWIGPNRLTRQLASPQYVDQLINIILFQRGHAMGVAVSIIIELIRKNNSDYDEVDLLSTTIVDNPPSQRDPVYLGHLLYELTMHMEDFYALLIKLENDDDDDHDTASKALPSVKHHLLENQLHESFRPLGFERVKITELISEMLHCSNMGLMNSKRGEKIARTRDKCRDTLDQNSLEKAMKNLNINDNTITSNTLEDKCNNNDSNDSNDNQKQKKNIKKKFHDNELYSTFDTSDDNIDDDDDMSFEIPYVSETQNLKIRKNPTIGDLFKIKLHDLGFFPKFLQLFLRYPWNNFWHNIVFDIIQQIFNGRMDFSYNSFLVYSLFDFKKSTRFIPKPLYGSNQKLPVKDFHIISDFILQGHKDSFEFYEKEKTNLGYMGQLVLIAEEIAKYSKIYKTDLIAPDIYAFLQDEVWMSYSSDILNETRTMCSIILGGGQFCAESDENTNQDFLEKADMSKPAHPSTMDENEIVHEEDVKLHDKVAELIDELGQLTELDIHDKIKDVIVDHHSDLN
SIO_010081: YGL229C
subclass of: SO_0000673
so part of: YGL229C
location: complement(64503..66959)
location: region:64503-66959:-1
so has part: feature:64503-66959:-1:exon

NP_011285.1
type: Protein
SIO_000068: ncbiprotein

S000003198
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:64503-66959:-1:exon

YGL228W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHE10
locus tag: YGL228W
so part of: sequence
location: <67598..>69331
location: region:67598-69331:1
so has part: feature:67598-69331:1:exon
subclass of: SO_0000010

852623
type: Gene
SIO_000068: ncbigene

position:67598:1
position: 67598
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:69331:1
position: 69331
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67598-69331:1:exon

YGL228W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHE10
locus tag: YGL228W
product: She10p
transcript id: NM_001181094.1
SIO_010081: YGL228W
subclass of: SO_0000673
so part of: YGL228W
location: <67598..>69331
location: region:67598-69331:1
so has part: feature:67598-69331:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:67598-69331:1:exon

YGL228W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHE10
locus tag: YGL228W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]
note: Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly
codon start: 1
product: She10p
translation: MGKLIKLITTLTVLVSLLQYCCEFNSGSISCERTQTLCHYTNPRVWNTYFSRNCELYKNKVSPGFDIVARKYDTAVKPVIDDATVKVNKVAIQPAFKVIHSQCKKWNCGKYYQLVRSPMVKTRRFFFAKYNAFVKPNLDKFFTAEFRSHLKERILKYKNIGHYYFTITSRCIKSKYDFIVGNTEEKLMGKFKNKDTHGIHGSVTREPSSEDMVLTVSTMESDEEELTTTSTQTVVETITLDQEEASAVANHAHDDEASTDVEGSTDVNVNEQALLQEDFDMWSETILQKTQDVIQLFEKDVSKYINGKLVEEANHFKAKFQSLDDKSKKFFSKISLAINDIECVEGIDSETGKKIFFDKSGSTEISQYITRELVREYFNETRSTLDELTNAMEKDLSEITDEIEKKVNAIREENVEVFEEWGDIIVNEWSKRMAYVDVINAHMGADDDTTLDEEKAKSSVNWKKFLKGKKQIIESRDKLAHHSADLSRVNAFRQKVQKKILSFTQESGEFLYILRSKANLQFQERERKERERKEREKAAAEEFQRQQELLRQQEEEDEEDVSYTSTSTITTTITMTL
SIO_010081: YGL228W
subclass of: SO_0000673
so part of: YGL228W
location: 67598..69331
location: region:67598-69331:1
so has part: feature:67598-69331:1:exon

NP_011286.1
type: Protein
SIO_000068: ncbiprotein

S000003197
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67598-69331:1:exon

YGL227W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GID1
gene: VID30
locus tag: YGL227W
gene synonym: GID1
so part of: sequence
location: <69671..>72547
location: region:69671-72547:1
so has part: feature:69671-72547:1:exon
subclass of: SO_0000010

852624
type: Gene
SIO_000068: ncbigene

position:69671:1
position: 69671
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:72547:1
position: 72547
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:69671-72547:1:exon

YGL227W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GID1
gene: VID30
locus tag: YGL227W
gene synonym: GID1
product: glucose-induced degradation complex subunit VID30
transcript id: NM_001181093.1
SIO_010081: YGL227W
subclass of: SO_0000673
so part of: YGL227W
location: <69671..>72547
location: region:69671-72547:1
so has part: feature:69671-72547:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:69671-72547:1:exon

YGL227W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GID1
gene: VID30
locus tag: YGL227W
gene synonym: GID1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0034657 GID complex [PMID:16872538|PMID:18508925]
experiment: EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:11356843]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616|PMID:15358789]
experiment: EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]
note: Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
codon start: 1
product: glucose-induced degradation complex subunit VID30
translation: MSEYMDDVDREFINCLFPSYLLQQPVAYDLWILYLQHRKLFHKLKNTNLINADENPTGVGMGRTKLTALTRKEIWSKLMNLGVLGTISFEAVNDDYLIQVYKYFYPDVNDFTLRFGVKDSNKNSVRVMKASSDMRKNAQELLEPVLSEREMALNSNTSLENDRNDDDDDDDDDDDDDDDDDDDDDESDLESLEGEVDTDTDDNNEGDGSDNHEEGGEEGSRGADADVSSAQQRAERVADPWIYQRSRSAINIETESRNLWDTSDKNSGLQYYPPDQSPSSSFSSPRVSSGNDKNDNEATNVLSNSGSKKKNSMIPDIYKILGYFLPSRWQAQPNNSLQLSQDGITHLQPNPDYHSYMTYERSSASSASTRNRLRTSFENSGKVDFAVTWANKSLPDNKLTIFYYEIKVLSVTSTESAENSNIVIGYKLVENELMEATTKKSVSRSSVAGSSSSLGGSNNMSSNRVPSTSFTMEGTQRRDYIYEGGVSAMSLNVDGSINKCQKYGFDLNVFGYCGFDGLITNSTEQSKEYAKPFGRDDVIGCGINFIDGSIFFTKNGIHLGNAFTDLNDLEFVPYVALRPGNSIKTNFGLNEDFVFDIIGYQDKWKSLAYEHICRGRQMDVSIEEFDSDESEEDETENGPEENKSTNVNEDLMDIDQEDGAAGNKDTKKLNDEKDNNLKFLLGEDNRFIDGKLVRPDVNNINNLSVDDGSLPNTLNVMINDYLIHEGLVDVAKGFLKDLQKDAVNVNGQHSESKDVIRHNERQIMKEERMVKIRQELRYLINKGQISKCINYIDNEIPDLLKNNLELVFELKLANYLVMIKKSSSKDDDEIENLILKGQELSNEFIYDTKIPQSLRDRFSGQLSNVSALLAYSNPLVEAPKEISGYLSDEYLQERLFQVSNNTILTFLHKDSECALENVISNTRAMLSTLLEYNAFGSTNSSDPRYYKAINFDEDVLNL
SIO_010081: YGL227W
subclass of: SO_0000673
so part of: YGL227W
location: 69671..72547
location: region:69671-72547:1
so has part: feature:69671-72547:1:exon

NP_011287.1
type: Protein
SIO_000068: ncbiprotein

S000003196
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:69671-72547:1:exon

YGL226C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OST5
locus tag: YGL226C-A
so part of: sequence
location: complement(<72749..>73158)
location: region:72749-73158:-1
so has part: feature:72749-73158:-1:exon
subclass of: SO_0000010

852625
type: Gene
SIO_000068: ncbigene

position:72749:-1
position: 72749
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73158:-1
position: 73158
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:72749-73158:-1:exon

YGL226C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OST5
locus tag: YGL226C-A
product: dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
transcript id: NM_001181091.1
SIO_010081: YGL226C-A
subclass of: SO_0000673
so part of: YGL226C-A
location: complement(join(<72749..72988,73138..>73158))
location: region:72749-73158:-1
so has part: feature:73138-73158:-1:exon
so has part: feature:72749-72988:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:73138-73158:-1:exon

position:73138:-1
position: 73138
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:72749-72988:-1:exon

position:72988:-1
position: 72988
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL226C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OST5
locus tag: YGL226C-A
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12805367]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084|PMID:12805367]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9135133]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins
codon start: 1
product: dolichyl-diphosphooligosaccharide--protein glycotransferase subunit
translation: MTYEQLYKEFHSSKSFQPFIHLDTQPKFAICGLIVTLAVLSSALFAVGSKSSYIKKLFFYTILSVIGSLFAGLTTVFASNSFGVYV
SIO_010081: YGL226C-A
subclass of: SO_0000673
so part of: YGL226C-A
location: complement(join(72749..72988,73138..73158))
location: region:72749-73158:-1
so has part: feature:73138-73158:-1:exon
so has part: feature:72749-72988:-1:exon

NP_011288.1
type: Protein
SIO_000068: ncbiprotein

S000003194
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73138-73158:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:72749-72988:-1:exon

YGL226W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTC3
locus tag: YGL226W
so part of: sequence
location: <73340..>73711
location: region:73340-73711:1
so has part: feature:73340-73711:1:exon
subclass of: SO_0000010

852626
type: Gene
SIO_000068: ncbigene

position:73340:1
position: 73340
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73711:1
position: 73711
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:73340-73711:1:exon

YGL226W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTC3
locus tag: YGL226W
product: Mtc3p
transcript id: NM_001181092.1
SIO_010081: YGL226W
subclass of: SO_0000673
so part of: YGL226W
location: <73340..>73711
location: region:73340-73711:1
so has part: feature:73340-73711:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:73340-73711:1:exon

YGL226W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTC3
locus tag: YGL226W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
codon start: 1
product: Mtc3p
translation: MMGRNGIRLALKRSFSTYQPPVVEITNITKLWPTLRPEVRDEIKEYLRWRMQEDWRHIPLEETKAAYFLSYGPCGGRSKGNEWNVGYTGMRIVFNLVLFGGAATAFYNWKQDKKLEEQLRDLV
SIO_010081: YGL226W
subclass of: SO_0000673
so part of: YGL226W
location: 73340..73711
location: region:73340-73711:1
so has part: feature:73340-73711:1:exon

NP_011289.1
type: Protein
SIO_000068: ncbiprotein

S000003195
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73340-73711:1:exon

YNCG0002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0002C
so part of: sequence
location: complement(73829..73902)
location: region:73829-73902:-1
so has part: feature:73829-73902:-1:exon
subclass of: SO_0000663

852627
type: Gene
SIO_000068: ncbigene

position:73829:-1
position: 73829
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:73902:-1
position: 73902
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:73829-73902:-1:exon

YNCG0002C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0002C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0002C
subclass of: SO_0000673
so part of: YNCG0002C
location: complement(73829..73902)
location: region:73829-73902:-1
so has part: feature:73829-73902:-1:exon

S000006757
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73829-73902:-1:exon

YGL225W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GOG5
alternative label: LDB3
alternative label: VAN2
alternative label: VIG4
gene: VRG4
locus tag: YGL225W
gene synonym: GOG5; LDB3; VAN2; VIG4
so part of: sequence
location: <76894..>77907
location: region:76894-77907:1
so has part: feature:76894-77907:1:exon
subclass of: SO_0000010

852647
type: Gene
SIO_000068: ncbigene

position:76894:1
position: 76894
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77907:1
position: 77907
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:76894-77907:1:exon

YGL225W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GOG5
alternative label: LDB3
alternative label: VAN2
alternative label: VIG4
gene: VRG4
locus tag: YGL225W
gene synonym: GOG5; LDB3; VAN2; VIG4
product: GDP-mannose transporter
transcript id: NM_001181090.1
SIO_010081: YGL225W
subclass of: SO_0000673
so part of: YGL225W
location: <76894..>77907
location: region:76894-77907:1
so has part: feature:76894-77907:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:76894-77907:1:exon

YGL225W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GOG5
alternative label: LDB3
alternative label: VAN2
alternative label: VIG4
gene: VRG4
locus tag: YGL225W
gene synonym: GOG5; LDB3; VAN2; VIG4
experiment: EXISTENCE:direct assay:GO:0005458 GDP-mannose transmembrane transporter activity [PMID:20576760]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9395539]
experiment: EXISTENCE:mutant phenotype:GO:0005458 GDP-mannose transmembrane transporter activity [PMID:9395539]
experiment: EXISTENCE:mutant phenotype:GO:1990570 GDP-mannose transmembrane transport [PMID:9395539]
note: Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication
codon start: 1
product: GDP-mannose transporter
translation: MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGYAKFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK
SIO_010081: YGL225W
subclass of: SO_0000673
so part of: YGL225W
location: 76894..77907
location: region:76894-77907:1
so has part: feature:76894-77907:1:exon

NP_011290.1
type: Protein
SIO_000068: ncbiprotein

S000003193
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:76894-77907:1:exon

YGL224C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSM1
gene: SDT1
locus tag: YGL224C
gene synonym: SSM1
so part of: sequence
location: complement(<78015..>78857)
location: region:78015-78857:-1
so has part: feature:78015-78857:-1:exon
subclass of: SO_0000010

852648
type: Gene
SIO_000068: ncbigene

position:78015:-1
position: 78015
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:78857:-1
position: 78857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78015-78857:-1:exon

YGL224C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSM1
gene: SDT1
locus tag: YGL224C
gene synonym: SSM1
product: nucleotidase
transcript id: NM_001181089.1
SIO_010081: YGL224C
subclass of: SO_0000673
so part of: YGL224C
location: complement(<78015..>78857)
location: region:78015-78857:-1
so has part: feature:78015-78857:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78015-78857:-1:exon

YGL224C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSM1
gene: SDT1
locus tag: YGL224C
gene synonym: SSM1
experiment: EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:11934891]
experiment: EXISTENCE:mutant phenotype:GO:0006206 pyrimidine nucleobase metabolic process [PMID:11934891]
note: Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication
codon start: 1
product: nucleotidase
translation: MTVEYTASDLATYQNEVNEQIAKNKAHLESLTHPGSKVTFPIDQDISATPQNPNLKVFFFDIDNCLYKSSTRIHDLMQQSILRFFQTHLKLSPEDAHVLNNSYYKEYGLAIRGLVMFHKVNALEYNRLVDDSLPLQDILKPDIPLRNMLLRLRQSGKIDKLWLFTNAYKNHAIRCLRLLGIADLFDGLTYCDYSRTDTLVCKPHVKAFEKAMKESGLARYENAYFIDDSGKNIETGIKLGMKTCIHLVENEVNEILGQTPEGAIVISDILELPHVVSDLF
SIO_010081: YGL224C
subclass of: SO_0000673
so part of: YGL224C
location: complement(78015..78857)
location: region:78015-78857:-1
so has part: feature:78015-78857:-1:exon

NP_011291.1
type: Protein
SIO_000068: ncbiprotein

S000003192
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78015-78857:-1:exon

YGL223C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COD3
alternative label: LDB11
alternative label: SEC36
gene: COG1
locus tag: YGL223C
gene synonym: COD3; LDB11; SEC36
so part of: sequence
location: complement(<79112..>80365)
location: region:79112-80365:-1
so has part: feature:79112-80365:-1:exon
subclass of: SO_0000010

852649
type: Gene
SIO_000068: ncbigene

position:79112:-1
position: 79112
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:80365:-1
position: 80365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:79112-80365:-1:exon

YGL223C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COD3
alternative label: LDB11
alternative label: SEC36
gene: COG1
locus tag: YGL223C
gene synonym: COD3; LDB11; SEC36
product: Golgi transport complex subunit COG1
transcript id: NM_001181088.1
SIO_010081: YGL223C
subclass of: SO_0000673
so part of: YGL223C
location: complement(<79112..>80365)
location: region:79112-80365:-1
so has part: feature:79112-80365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:79112-80365:-1:exon

YGL223C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COD3
alternative label: LDB11
alternative label: SEC36
gene: COG1
locus tag: YGL223C
gene synonym: COD3; LDB11; SEC36
experiment: EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0007030 Golgi organization [PMID:15932880]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:15932880]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
note: Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG1
translation: MDEVLPLFRDSHIPQIKDYQLELQNDLTKTNEAFQKNLLKNYNKILSLTDSVNDLSLNLKNVDQDFKSLCFNDEKFQLNKLTPLPYQTTTHISPPRDEEKVSIPSQNILVISNWTISINNFCNRIVTSTTPSRIFDELLLNFHELSLIPVPSKFEALVKDKCCRLQKFLVDSMKTLNLTLLQWVKLYNLLNTEFSSKWDDDLLSIFNESLFETLFNDNVQALLISSANSKDHQYHSNQQYKDAIVVDFVNSSTFRDHLIRRTVKEINTHLDTLSTLRAKLKEPETLHKLDIFHDNDTNLNDGTVSPLDDDALKQYIDTAVFYSKGLTNDTTLQIYQTVQPTIEILQNLELYKCPQETLTDLRNKLITQLQEFKTQISSRLPSPLENSTSVVDDFITSYNNHNLLQLVIDQITQLRQQ
SIO_010081: YGL223C
subclass of: SO_0000673
so part of: YGL223C
location: complement(79112..80365)
location: region:79112-80365:-1
so has part: feature:79112-80365:-1:exon

NP_011292.1
type: Protein
SIO_000068: ncbiprotein

S000003191
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:79112-80365:-1:exon

YGL222C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EDC1
locus tag: YGL222C
so part of: sequence
location: complement(<80659..>81186)
location: region:80659-81186:-1
so has part: feature:80659-81186:-1:exon
subclass of: SO_0000010

852650
type: Gene
SIO_000068: ncbigene

position:80659:-1
position: 80659
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:81186:-1
position: 81186
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80659-81186:-1:exon

YGL222C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EDC1
locus tag: YGL222C
product: Edc1p
transcript id: NM_001181087.1
SIO_010081: YGL222C
subclass of: SO_0000673
so part of: YGL222C
location: complement(<80659..>81186)
location: region:80659-81186:-1
so has part: feature:80659-81186:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80659-81186:-1:exon

YGL222C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EDC1
locus tag: YGL222C
experiment: EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12554867]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:12554867]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19682251]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19682251|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0098745 Dcp1-Dcp2 complex [PMID:11139489]
experiment: EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:19682251]
experiment: EXISTENCE:physical interaction:GO:0098745 Dcp1-Dcp2 complex [PMID:11139489]
note: RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication
codon start: 1
product: Edc1p
translation: MSTDTMYFNSSRLLPSAGRNKTNNLIKQKTRNNRARGNAAKNANNNNYITDIPPPQTLPNGQKPNFGHSSNKKPSFNQKKHSPPSSPSSTTTLGKKNRQNNKETPRQNNKDDTRLLSQNLKNLLLNQKQSPHGSQGIIPMGCNGSAKKLSHSYAGSTFATNGPREAKNLPKPSFL
SIO_010081: YGL222C
subclass of: SO_0000673
so part of: YGL222C
location: complement(80659..81186)
location: region:80659-81186:-1
so has part: feature:80659-81186:-1:exon

NP_011293.1
type: Protein
SIO_000068: ncbiprotein

S000003190
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80659-81186:-1:exon

YGL221C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NIF3
locus tag: YGL221C
so part of: sequence
location: complement(<81426..>82292)
location: region:81426-82292:-1
so has part: feature:81426-82292:-1:exon
subclass of: SO_0000010

852651
type: Gene
SIO_000068: ncbigene

position:81426:-1
position: 81426
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82292:-1
position: 82292
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81426-82292:-1:exon

YGL221C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NIF3
locus tag: YGL221C
product: uncharacterized protein
transcript id: NM_001181086.1
SIO_010081: YGL221C
subclass of: SO_0000673
so part of: YGL221C
location: complement(<81426..>82292)
location: region:81426-82292:-1
so has part: feature:81426-82292:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81426-82292:-1:exon

YGL221C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NIF3
locus tag: YGL221C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17034789|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17034789|PMID:14562095|PMID:16823961|PMID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: uncharacterized protein
translation: MSRAITRAQLDKLVRSITKFYPQKYADKSWDNTGLLIDCSTAQVTTADANAKTKVLLTVDLTKSVAQEAVDANCNVIVAYHPFIFPSWNRLSPHTNPQHETAIKLIQYGISVYCPHTAVDAARGGVNDWLVRGLNNGENVAKSYALETVSGETDDLIGYGRFVEFNKDISLEQIVKNVKRVLRVPYVQVASLAAPSAWNQLKIKKVAVCAGSGSGVFKQLKEDVDLYYTGEMSHHEVLKWKEMGKTVIVCNHSNTERGFLQDVMKGLLQDEGHEVVVSKMDCDPLTVA
SIO_010081: YGL221C
subclass of: SO_0000673
so part of: YGL221C
location: complement(81426..82292)
location: region:81426-82292:-1
so has part: feature:81426-82292:-1:exon

NP_011294.1
type: Protein
SIO_000068: ncbiprotein

S000003189
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81426-82292:-1:exon

YGL220W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AIM15
alternative label: FRA2
gene: BOL2
locus tag: YGL220W
gene synonym: AIM15; FRA2
so part of: sequence
location: <82374..>82736
location: region:82374-82736:1
so has part: feature:82374-82736:1:exon
subclass of: SO_0000010

852652
type: Gene
SIO_000068: ncbigene

position:82374:1
position: 82374
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82736:1
position: 82736
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:82374-82736:1:exon

YGL220W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AIM15
alternative label: FRA2
gene: BOL2
locus tag: YGL220W
gene synonym: AIM15; FRA2
product: Bol2p
transcript id: NM_001181085.1
SIO_010081: YGL220W
subclass of: SO_0000673
so part of: YGL220W
location: <82374..>82736
location: region:82374-82736:1
so has part: feature:82374-82736:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:82374-82736:1:exon

YGL220W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AIM15
alternative label: FRA2
gene: BOL2
locus tag: YGL220W
gene synonym: AIM15; FRA2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]
experiment: EXISTENCE:direct assay:GO:0051536 iron-sulfur cluster binding [PMID:31493153]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]
note: Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2
codon start: 1
product: Bol2p
translation: MTGERIEKVKINDEFAKSHFLTTQWRETKRQRHYKMPVTEQGLRERIESAIPQVYHIIVTDLSYGCGQSFDIVVVSDFFQGKSKLMRSRAVNKAVKEELQEIHAFSCKCYTEEEWSKIVV
SIO_010081: YGL220W
subclass of: SO_0000673
so part of: YGL220W
location: 82374..82736
location: region:82374-82736:1
so has part: feature:82374-82736:1:exon

NP_011295.1
type: Protein
SIO_000068: ncbiprotein

S000003188
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:82374-82736:1:exon

YGL219C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMM2
gene: MDM34
locus tag: YGL219C
gene synonym: MMM2
so part of: sequence
location: complement(<82878..>84257)
location: region:82878-84257:-1
so has part: feature:82878-84257:-1:exon
subclass of: SO_0000010

852654
type: Gene
SIO_000068: ncbigene

position:82878:-1
position: 82878
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:84257:-1
position: 84257
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:82878-84257:-1:exon

YGL219C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMM2
gene: MDM34
locus tag: YGL219C
gene synonym: MMM2
product: ERMES complex subunit MDM34
transcript id: NM_001181084.1
SIO_010081: YGL219C
subclass of: SO_0000673
so part of: YGL219C
location: complement(<82878..>84257)
location: region:82878-84257:-1
so has part: feature:82878-84257:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:82878-84257:-1:exon

YGL219C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMM2
gene: MDM34
locus tag: YGL219C
gene synonym: MMM2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:14981098|PMID:16407407]
experiment: EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]
experiment: EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]
experiment: EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:21945531]
note: Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase
codon start: 1
product: ERMES complex subunit MDM34
translation: MSFRFNEAVFGDNSFNERIREKLSTALNSPSKKKLDILKSGIKVQKVDFPTIPQLEILDLDIITQPKSLAKGICKISCKDAMLRIQTVIESNLLLINEQDTPSFTMPQLINNGSFTIPITMTFSSIELEAITNIFVKNPGIGISFNDVDLDFKFDCSVKILQSTIERRLKESMHVVFKDVLPSLIFNTSQNWFTNRGESTSTIPGKREHHHQQTTMSRNVILDGSDFQELSPINMLRLSSIVSSRSTLSLHSTVMNSLSAIPGCLERQNLYRFISRMPSLNNYYSSQSFPQPKSSTVSSKQLVKPFYCSHNLLPKTVLDSSQYDLATITKIQSRLFDRSNSNDDNAKPRRRKIKCKKTRTPSNLQSQGEQAVDDSTAIETVTSTPVQTPIPELEEQSPPYLKTTVSIRDKYVIPEKISLNLDSKKDTSKKKPFYFIGLNSQEPSNNWKWGMEDSPPPYH
SIO_010081: YGL219C
subclass of: SO_0000673
so part of: YGL219C
location: complement(82878..84257)
location: region:82878-84257:-1
so has part: feature:82878-84257:-1:exon

NP_011296.1
type: Protein
SIO_000068: ncbiprotein

S000003187
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:82878-84257:-1:exon

YGL216W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KIP3
locus tag: YGL216W
so part of: sequence
location: <84885..>87302
location: region:84885-87302:1
so has part: feature:84885-87302:1:exon
subclass of: SO_0000010

852655
type: Gene
SIO_000068: ncbigene

position:84885:1
position: 84885
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:87302:1
position: 87302
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:84885-87302:1:exon

YGL216W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KIP3
locus tag: YGL216W
product: tubulin-dependent ATPase KIP3
transcript id: NM_001181081.1
SIO_010081: YGL216W
subclass of: SO_0000673
so part of: YGL216W
location: <84885..>87302
location: region:84885-87302:1
so has part: feature:84885-87302:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:84885-87302:1:exon

YGL216W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KIP3
locus tag: YGL216W
experiment: EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:9693366]
experiment: EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:9693366]
experiment: EXISTENCE:direct assay:GO:0008574 plus-end-directed microtubule motor activity [PMID:16906145|PMID:16906148]
experiment: EXISTENCE:direct assay:GO:0070462 plus-end specific microtubule depolymerization [PMID:16906145|PMID:16906148]
experiment: EXISTENCE:direct assay:GO:0070463 tubulin-dependent ATPase activity [PMID:16906148]
experiment: EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:9281582|PMID:16906148]
experiment: EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]
experiment: EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:10525539]
experiment: EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9693366]
experiment: EXISTENCE:mutant phenotype:GO:0031115 negative regulation of microtubule polymerization [PMID:24616221]
experiment: EXISTENCE:mutant phenotype:GO:0032888 regulation of mitotic spindle elongation [PMID:24616221]
experiment: EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:31964755]
experiment: EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:23851487|PMID:9813090]
experiment: EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:23851487]
note: Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone
codon start: 1
product: tubulin-dependent ATPase KIP3
translation: MNVPETRQSSIVVAIRVRPFTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGSTRSKRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSINNSNATNKFSSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGTPSQPGIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIREDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITEQKRQIEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFLQMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVIHQVHSIDLNKLREMEDWDETYDLVYLESCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFESFARTFIANPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFNEQGPSTPSAPTTAVPRRKMRSSLLTHQSLLATARK
SIO_010081: YGL216W
subclass of: SO_0000673
so part of: YGL216W
location: 84885..87302
location: region:84885-87302:1
so has part: feature:84885-87302:1:exon

NP_011299.1
type: Protein
SIO_000068: ncbiprotein

S000003184
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:84885-87302:1:exon

YGL215W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CLG1
locus tag: YGL215W
so part of: sequence
location: <87981..>89339
location: region:87981-89339:1
so has part: feature:87981-89339:1:exon
subclass of: SO_0000010

852657
type: Gene
SIO_000068: ncbigene

position:87981:1
position: 87981
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:89339:1
position: 89339
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:87981-89339:1:exon

YGL215W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CLG1
locus tag: YGL215W
product: Clg1p
transcript id: NM_001181080.1
SIO_010081: YGL215W
subclass of: SO_0000673
so part of: YGL215W
location: <87981..>89339
location: region:87981-89339:1
so has part: feature:87981-89339:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:87981-89339:1:exon

YGL215W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CLG1
locus tag: YGL215W
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9032248]
experiment: EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9032248]
note: Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
codon start: 1
product: Clg1p
translation: MANTFKYYPETMGNSSGYPISLPFPKGSATSAVNVARQLPKYLGHVPSQSVHTQLPSMASLGYFNQPSSTYYAPPAPLQQHQQPPILPPPGLMYTSNNNSNVIPPPVQMIRDGQQQPQQSNQVNGGVSENLDYDISIMSKFIMENAFVAFNANYSTDDQTTDLFFKGISSVLNATRLPSATIFLAIDYLFKYINKLSNGIHSIGGNSINIIYQNTMIAFILANKFNDDKTFTNNSWSQATGILINVINDFERQWLRIFNWELYDSAFLYFEFVKNFEIFKQNQLKPAVAVPTLLSPIVNVGDTRNVNFNLKPTSTNNLLSPVSNYETPMLMPHNMFSSPSYQSNSRSEFSSMNGYYNYYNYNQPRLNYYQQFPNIYSSPISETQFDYDFYNFSSQQQQQQQKQHSLLPAAPQLPPPHVHNQSYGHHLGWKSMDDTINHSRFERNYFPYSAVY
SIO_010081: YGL215W
subclass of: SO_0000673
so part of: YGL215W
location: 87981..89339
location: region:87981-89339:1
so has part: feature:87981-89339:1:exon

NP_011300.1
type: Protein
SIO_000068: ncbiprotein

S000003183
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:87981-89339:1:exon

YGL213C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: REC103
gene: SKI8
locus tag: YGL213C
gene synonym: REC103
so part of: sequence
location: complement(<90054..>91247)
location: region:90054-91247:-1
so has part: feature:90054-91247:-1:exon
subclass of: SO_0000010

852659
type: Gene
SIO_000068: ncbigene

position:90054:-1
position: 90054
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:91247:-1
position: 91247
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:90054-91247:-1:exon

YGL213C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: REC103
gene: SKI8
locus tag: YGL213C
gene synonym: REC103
product: SKI complex subunit WD repeat protein SKI8
transcript id: NM_001181078.1
SIO_010081: YGL213C
subclass of: SO_0000673
so part of: YGL213C
location: complement(<90054..>91247)
location: region:90054-91247:-1
so has part: feature:90054-91247:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:90054-91247:-1:exon

YGL213C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: REC103
gene: SKI8
locus tag: YGL213C
gene synonym: REC103
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:14992724]
experiment: EXISTENCE:direct assay:GO:0055087 Ski complex [PMID:18042677|PMID:10744028]
experiment: EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:14992724]
experiment: EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:14992724]
experiment: EXISTENCE:mutant phenotype:GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [PMID:9482746]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:14992724]
experiment: EXISTENCE:mutant phenotype:GO:0065004 protein-DNA complex assembly [PMID:14992724]
experiment: EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]
experiment: EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]
experiment: EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:14992724]
experiment: EXISTENCE:physical interaction:GO:0055087 Ski complex [PMID:18042677]
note: Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype
codon start: 1
product: SKI complex subunit WD repeat protein SKI8
translation: MSKVFIATANAGKAHDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGDSLAEPGVFDVKFLKKGWRSGMGADLNESLCCVCLDRSIRWFREAGGK
SIO_010081: YGL213C
subclass of: SO_0000673
so part of: YGL213C
location: complement(90054..91247)
location: region:90054-91247:-1
so has part: feature:90054-91247:-1:exon

NP_011302.1
type: Protein
SIO_000068: ncbiprotein

S000003181
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:90054-91247:-1:exon

YGL212W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VPL24
alternative label: VPS43
gene: VAM7
locus tag: YGL212W
gene synonym: VPL24; VPS43
so part of: sequence
location: <91432..>92382
location: region:91432-92382:1
so has part: feature:91432-92382:1:exon
subclass of: SO_0000010

852660
type: Gene
SIO_000068: ncbigene

position:91432:1
position: 91432
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:92382:1
position: 92382
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:91432-92382:1:exon

YGL212W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VPL24
alternative label: VPS43
gene: VAM7
locus tag: YGL212W
gene synonym: VPL24; VPS43
product: Vam7p
transcript id: NM_001181077.1
SIO_010081: YGL212W
subclass of: SO_0000673
so part of: YGL212W
location: <91432..>92382
location: region:91432-92382:1
so has part: feature:91432-92382:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:91432-92382:1:exon

YGL212W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VPL24
alternative label: VPS43
gene: VAM7
locus tag: YGL212W
gene synonym: VPL24; VPS43
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11433291|PMID:16984909|PMID:26928762|PMID:27881666]
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:26774783]
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:19805279]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]
experiment: EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]
experiment: EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:16984909]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0031201 SNARE complex [PMID:9628864]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:27365394]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]
experiment: EXISTENCE:mutant phenotype:GO:0061909 autophagosome-lysosome fusion [PMID:26774783]
experiment: EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:9628864]
note: Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
codon start: 1
product: Vam7p
translation: MAANSVGKMSEKLRIKVDDVKINPKYVLYGVSTPNKRLYKRYSEFWKLKTRLERDVGSTIPYDFPEKPGVLDRRWQRRYDDPEMIDERRIGLERFLNELYNDRFDSRWRDTKIAQDFLQLSKPNVSQEKSQQHLETADEVGWDEMIRDIKLDLDKESDGTPSVRGALRARTKLHKLRERLEQDVQKKSLPSTEVTRRAALLRSLLKECDDIGTANIAQDRGRLLGVATSDNSSTTEVQGRTNNDLQQGQMQMVRDQEQELVALHRIIQAQRGLALEMNEELQTQNELLTALEDDVDNTGRRLQIANKKARHFNNSA
SIO_010081: YGL212W
subclass of: SO_0000673
so part of: YGL212W
location: 91432..92382
location: region:91432-92382:1
so has part: feature:91432-92382:1:exon

NP_011303.1
type: Protein
SIO_000068: ncbiprotein

S000003180
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:91432-92382:1:exon

YGL211W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TUC1
alternative label: YGL210W-A
gene: NCS6
locus tag: YGL211W
gene synonym: TUC1; YGL210W-A
so part of: sequence
location: <92512..>93591
location: region:92512-93591:1
so has part: feature:92512-93591:1:exon
subclass of: SO_0000010

852661
type: Gene
SIO_000068: ncbigene

position:92512:1
position: 92512
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:93591:1
position: 93591
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:92512-93591:1:exon

YGL211W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TUC1
alternative label: YGL210W-A
gene: NCS6
locus tag: YGL211W
gene synonym: TUC1; YGL210W-A
product: Ncs6p
transcript id: NM_001181076.1
SIO_010081: YGL211W
subclass of: SO_0000673
so part of: YGL211W
location: <92512..>93591
location: region:92512-93591:1
so has part: feature:92512-93591:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:92512-93591:1:exon

YGL211W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TUC1
alternative label: YGL210W-A
gene: NCS6
locus tag: YGL211W
gene synonym: TUC1; YGL210W-A
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19145231]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18664566]
experiment: EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:17592039|PMID:18755837]
experiment: EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:18664566|PMID:19145231|PMID:19151091]
experiment: EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]
note: Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; localizes to cytosol and peroxisomes
codon start: 1
product: Ncs6p
translation: MSFTAPSDPVNKPTKVKVSQLCELCHSRKALIRRPKNLSKLCKQCFCLVFETEIHNTIVANNLFQRGEKVAVGASGGKDSTVLAHMLKLLNDRYDYGIEIVLLSIDEGIIGYRDDSLATVKRNQQQYGLPLEIFSFKDLYDWTMDEIVSVAGIRNSCTYCGVFRRQSLDRGAAKLGISHVVTGHNADDMAETVLMNILRGDVARLEKSTAIITQSSGSPIKRSKPFKYSYQKEIVLYAHYMKLDYFSTECTYAPEAFRGTAREYMKNLEAVRPSCIIDIIQSGENLALKAKKSNAGKRVVKFVDGNRCARCGYLSSNNICKACMLLEGLEKSRAQVAIENDTSADGAALKLRALEKLSF
SIO_010081: YGL211W
subclass of: SO_0000673
so part of: YGL211W
location: 92512..93591
location: region:92512-93591:1
so has part: feature:92512-93591:1:exon

NP_011304.2
type: Protein
SIO_000068: ncbiprotein

S000003179
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:92512-93591:1:exon

YGL210W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YPT32
locus tag: YGL210W
so part of: sequence
location: <93792..>94460
location: region:93792-94460:1
so has part: feature:93792-94460:1:exon
subclass of: SO_0000010

852662
type: Gene
SIO_000068: ncbigene

position:93792:1
position: 93792
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:94460:1
position: 94460
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:93792-94460:1:exon

YGL210W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YPT32
locus tag: YGL210W
product: Rab family GTPase YPT32
transcript id: NM_001181075.1
SIO_010081: YGL210W
subclass of: SO_0000673
so part of: YGL210W
location: <93792..>94460
location: region:93792-94460:1
so has part: feature:93792-94460:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:93792-94460:1:exon

YGL210W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YPT32
locus tag: YGL210W
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:15537705]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9151665]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9151665]
note: Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
codon start: 1
product: Rab family GTPase YPT32
translation: MSNEDYGYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEFATRTIEVENKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENCNHWLTELRENADDNVAVGLIGNKSDLAHLRAVPTDEAKNFAMENQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTNNMGSNGAPKGPTISLTPAPKEDKKKKSSNCC
SIO_010081: YGL210W
subclass of: SO_0000673
so part of: YGL210W
location: 93792..94460
location: region:93792-94460:1
so has part: feature:93792-94460:1:exon

NP_011305.1
type: Protein
SIO_000068: ncbiprotein

S000003178
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:93792-94460:1:exon

YGL209W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MLZ1
gene: MIG2
locus tag: YGL209W
gene synonym: MLZ1
so part of: sequence
location: <95858..>97006
location: region:95858-97006:1
so has part: feature:95858-97006:1:exon
subclass of: SO_0000010

852663
type: Gene
SIO_000068: ncbigene

position:95858:1
position: 95858
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97006:1
position: 97006
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:95858-97006:1:exon

YGL209W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MLZ1
gene: MIG2
locus tag: YGL209W
gene synonym: MLZ1
product: Mig2p
transcript id: NM_001181074.1
SIO_010081: YGL209W
subclass of: SO_0000673
so part of: YGL209W
location: <95858..>97006
location: region:95858-97006:1
so has part: feature:95858-97006:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:95858-97006:1:exon

YGL209W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MLZ1
gene: MIG2
locus tag: YGL209W
gene synonym: MLZ1
experiment: EXISTENCE:direct assay:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:8756637]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8756637|PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22353369|PMID:9832517|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22353369]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]
experiment: EXISTENCE:genetic interaction:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:8756637|PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]
experiment: EXISTENCE:mutant phenotype:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:9832517]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]
note: Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose
codon start: 1
product: Mig2p
translation: MPKKQTNFPVDNENRPFRCDTCHRGFHRLEHKKRHLRTHTGEKPHHCAFPGCGKSFSRSDELKRHMRTHTGQSQRRLKKASVQKQEFLTVSGIPTIASGVMIHQPIPQVLPANMAINVQAVNGGNIIHAPNAVHPMVIPIMAQPAPIHASAASFQPATSPMPISTYTPVPSQSFTSFQSSIGSIQSNSDVSSIFSNMNVRVNTPRSVPNSPNDGYLHQQHIPQQYQHQTASPSVAKQQKTFAHSLASALSTLQKRTPVSAPSTTIESPSSPSDSSHTSASSSAISLPFSNAPSQLAVAKELESVYLDSNRYTTKTRRERAKFEIPEEQEEDTNNSSSGSNEEEHESLDHESSKSRKKLSGVKLPPVRNLLKQIDVFNGPKRV
SIO_010081: YGL209W
subclass of: SO_0000673
so part of: YGL209W
location: 95858..97006
location: region:95858-97006:1
so has part: feature:95858-97006:1:exon

NP_011306.1
type: Protein
SIO_000068: ncbiprotein

S000003177
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:95858-97006:1:exon

YGL208W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPM2
gene: SIP2
locus tag: YGL208W
gene synonym: SPM2
so part of: sequence
location: <97338..>98585
location: region:97338-98585:1
so has part: feature:97338-98585:1:exon
subclass of: SO_0000010

852664
type: Gene
SIO_000068: ncbigene

position:97338:1
position: 97338
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:98585:1
position: 98585
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:97338-98585:1:exon

YGL208W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPM2
gene: SIP2
locus tag: YGL208W
gene synonym: SPM2
product: Sip2p
transcript id: NM_001181073.2
SIO_010081: YGL208W
subclass of: SO_0000673
so part of: YGL208W
location: <97338..>98585
location: region:97338-98585:1
so has part: feature:97338-98585:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:97338-98585:1:exon

YGL208W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPM2
gene: SIP2
locus tag: YGL208W
gene synonym: SPM2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11331606]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562756]
experiment: EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914]
experiment: EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12556493]
experiment: EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:10990457]
experiment: EXISTENCE:genetic interaction:GO:0007165 signal transduction [PMID:10990457]
experiment: EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:9121458]
experiment: EXISTENCE:genetic interaction:GO:0140767 enzyme-substrate adaptor activity [PMID:27592031]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:10921902]
experiment: EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:7813428|PMID:9121458]
note: One of three alternate beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication
codon start: 1
product: Sip2p
translation: MGTTTSHPAQKKQTTKKCRAPIMSDVREKPSNAQGCEPQEMDAVSKKVTELSLNKCSDSQDAGQPSREGSITKKKSTLLLRDEDEPTMPKLSVMETAVDTDSGSSSTSDDEEGDIIAQTTEPKQDASPDDDRSGHSSPREEGQQQIRAKEASGGPSEIKSSLMVPVEIRWQQGGSKVYVTGSFTKWRKMIGLIPDSDNNGSFHVKLRLLPGTHRFRFIVDNELRVSDFLPTATDQMGNFVNYIEVRQPEKNPTNEKIRSKEADSMRPPTSDRSSIALQIGKDPDDFGDGYTRFHEDLSPRPPLEYTTDIPAVFTDPSVMERYYYTLDRQQSNTDTSWLTPPQLPPQLENVILNKYYATQDQFNENNSGALPIPNHVVLNHLVTSSIKHNTLCVASIVRYKQKYVTQILYTPIESS
SIO_010081: YGL208W
subclass of: SO_0000673
so part of: YGL208W
location: 97338..98585
location: region:97338-98585:1
so has part: feature:97338-98585:1:exon

NP_011307.1
type: Protein
SIO_000068: ncbiprotein

S000003176
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:97338-98585:1:exon

YGL207W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CDC68
alternative label: SSF1
gene: SPT16
locus tag: YGL207W
gene synonym: CDC68; SSF1
so part of: sequence
location: <98969..>102076
location: region:98969-102076:1
so has part: feature:98969-102076:1:exon
subclass of: SO_0000010

852665
type: Gene
SIO_000068: ncbigene

position:98969:1
position: 98969
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:102076:1
position: 102076
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98969-102076:1:exon

YGL207W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CDC68
alternative label: SSF1
gene: SPT16
locus tag: YGL207W
gene synonym: CDC68; SSF1
product: chromatin-remodeling protein SPT16
transcript id: NM_001181072.1
SIO_010081: YGL207W
subclass of: SO_0000673
so part of: YGL207W
location: <98969..>102076
location: region:98969-102076:1
so has part: feature:98969-102076:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98969-102076:1:exon

YGL207W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CDC68
alternative label: SSF1
gene: SPT16
locus tag: YGL207W
gene synonym: CDC68; SSF1
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10413469]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10413469]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:19683499]
experiment: EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:12952948|PMID:15082784]
experiment: EXISTENCE:direct assay:GO:0007063 regulation of sister chromatid cohesion [PMID:31582854]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18089575]
experiment: EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15987999]
experiment: EXISTENCE:genetic interaction:GO:0035101 FACT complex [PMID:11432837]
experiment: EXISTENCE:genetic interaction:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:15987999]
experiment: EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:19574230]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226635]
experiment: EXISTENCE:physical interaction:GO:0006261 DNA-templated DNA replication [PMID:9199353]
experiment: EXISTENCE:physical interaction:GO:0035101 FACT complex [PMID:11432837]
note: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization
codon start: 1
product: chromatin-remodeling protein SPT16
translation: MEELNIDFDVFKKRIELLYSKYNEFEGSPNSLLFVLGSSNAENPYQKTTILHNWLLSYEFPATLIALVPGKVIIITSSAKAKHLQKAIDLFKDPESKITLELWQRNNKEPELNKKLFDDVIALINSAGKTVGIPEKDSYQGKFMTEWNPVWEAAVKENEFNVIDISLGLSKVWEVKDVNEQAFLSVSSKGSDKFMDLLSNEMVRAVDEELKITNAKLSDKIENKIDDVKFLKQLSPDLSALCPPNYKFNFDLLDWTYSPIIQSGKKFDLRVSARSTNDQLYGNGCILASCGIRYNNYCSNITRTFLIDPSEEMANNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNIGSLIGLEFRDSNFILNVKNDYRKIQRGDCFNISFGFNNLKDSQSANNYALQLADTVQIPLDETEPPRFLTNYTKAKSQISFYFNNEEEDNNKKKSSPATKVPSKPDRNSKILRTKLRGEARGGAEDAQKEQIRKENQKKLHEKLEKNGLLRFSAADANGPDSEPRQYFKKYESYVRDSQLPTNIRDLRIHVDWKSQTIILPIYGRPVPFHINSYKNGSKNEEGEYTYLRLNFNSPGSSGGISKKVEELPYEESADNQFVRSITLRSKDGDRMSETFKQIADLKKEATKREQERKALADVVQQDKLIENKTGRTKRLDQIFVRPNPDTKRVPSTVFIHENGIRFQSPLRTDSRIDILFSNIKNLIFQSCKGELIVVIHIHLKNPILMGKKKIQDVQFYREASDMSVDETGGGRRGQSRFRRYGDEDELEQEQEERRKRAALDKEFKYFADAIAEASNGLLTVENTFRDLGFQGVPNRSAVFCMPTTDCLVQLIEPPFLVINLEEVEICILERVQFGLKNFDMVFVYKDFNKPVTHINTVPIESLDFLKQWLTDMDIPYTVSTINLNWATIMKSLQDDPYQFFLDGGWNFLATGSDDEASDESEEEVSEYEASEDDVSDESAFSEDEEGSEVDDDISGDESEDYTGDESEEGEDWDELEKKAARADRGANFRD
SIO_010081: YGL207W
subclass of: SO_0000673
so part of: YGL207W
location: 98969..102076
location: region:98969-102076:1
so has part: feature:98969-102076:1:exon

NP_011308.1
type: Protein
SIO_000068: ncbiprotein

S000003175
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98969-102076:1:exon

YGL206C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SWA5
gene: CHC1
locus tag: YGL206C
gene synonym: SWA5
so part of: sequence
location: complement(<102543..>107504)
location: region:102543-107504:-1
so has part: feature:102543-107504:-1:exon
subclass of: SO_0000010

852666
type: Gene
SIO_000068: ncbigene

position:102543:-1
position: 102543
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:107504:-1
position: 107504
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102543-107504:-1:exon

YGL206C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SWA5
gene: CHC1
locus tag: YGL206C
gene synonym: SWA5
product: clathrin heavy chain
transcript id: NM_001181071.1
SIO_010081: YGL206C
subclass of: SO_0000673
so part of: YGL206C
location: complement(<102543..>107504)
location: region:102543-107504:-1
so has part: feature:102543-107504:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:102543-107504:-1:exon

YGL206C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SWA5
gene: CHC1
locus tag: YGL206C
gene synonym: SWA5
experiment: EXISTENCE:direct assay:GO:0006897 endocytosis [PMID:16643280]
experiment: EXISTENCE:genetic interaction:GO:0030866 cortical actin cytoskeleton organization [PMID:12181333]
experiment: EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:27062026]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16643280|PMID:27062026]
experiment: EXISTENCE:mutant phenotype:GO:0030866 cortical actin cytoskeleton organization [PMID:12181333]
note: Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function
codon start: 1
product: clathrin heavy chain
translation: MSDLPIEFTELVDLMSLGISPQFLDFRSTTFESDHFVTVRETKDGTNSVAIVDLAKGNEVTRKNMGGDSAIMHPSQMVISVRANGTIVQIFNLETKSKLKSFTLDEPVIFWRWLSETTLGFVTARSILTSNVFDGNVNAKPQLLTLRHANLNNTQIINFVANKNLDWFAVVGILQENGRIAGRIQLFSKQRNISQAIDGHVAIFTNILLEGNGSTPVQVFVTGNRNATTGAGELRIIEIDHDASLPSQYQKETTDIFFPPDATNDFPIAVQVSEKYGIIYLLTKYGFIHLYELETGTNLFVNRITAESVFTAAPYNHENGIACINKKGQVLAVEISTSQIVPYILNKLSNVALALIVATRGGLPGADDLFQKQFESLLLQNDYQNAAKVAASSTSLRNQNTINRLKNIQAPPGAISPILLYFSTLLDKGKLNKEETIELARPVLQQDRKQLFEKWLKEDKLECSEELGDIVKPFDTTLALACYLRAGAHAKVISCLAELQQFEKIIPYCQKVGYQPNFLVLISSLIRSSPDRASEFAVSLLQNPETASQIDIEKIADLFFSQNHIQQGTSLLLDALKGDTPDQGHLQTRVLEVNLLHAPQVADAILGNNIFSHYDKPTIASLSEKAGLYQRALENYTDIKDIKRCVVHTNALPIDWLVGYFGKLNVEQSLACLKALMDNNIQANIQTVVQVATKFSDLIGPSTLIKLFEDYNATEGLYYYLASLVNLTEDKDVVYKYIEAAAKMKQYREIERIVKDNNVYDPERVKNFLKDANLEDQLPLVIVCDRFDFVHEMILYLYKSQNLKFIETYVQQVNPSKTAQVVGALLDMDCDEAFIQSLLQSVLGQVPINELTTEVEKRNRLKILLPFLEQSLSQGIQDQAVYNALAKIYIDSNNSPEKFLKENDQYDTLDVGHYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLERSDLDLWNKVLNQENIHRRQLIDSVISVGIPELTDPEPVSLTVQAFMTNGLKLELIELLEKIILEPSPFNENVALQGLLLLSAIKYEPTKVSSYIEKLDNYDADEIAPLCIEHDLKEEAFEIYDKHEMYGKALKVLIEDIMSLDRAASYADKINTPELWSQIGTAQLDGLRIPDAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTLKEPKIDGALILAYAELNKIHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLASTLVYLGDYQAAVDTARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNGYFEELISLFEAGLGLERAHMGMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWSELVFLYAHYDEWDNAALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDLLTSLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQDAVDSYDKFDQLGLASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAAISQDPKVVEALLTYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISIKKEQNDSIKKITEELAKKSGSNEEHKDGQPLMLMNSAMNVQPTGF
SIO_010081: YGL206C
subclass of: SO_0000673
so part of: YGL206C
location: complement(102543..107504)
location: region:102543-107504:-1
so has part: feature:102543-107504:-1:exon

NP_011309.1
type: Protein
SIO_000068: ncbiprotein

S000003174
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:102543-107504:-1:exon

YGL205W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FOX1
gene: POX1
locus tag: YGL205W
gene synonym: FOX1
so part of: sequence
location: <108158..>110404
location: region:108158-110404:1
so has part: feature:108158-110404:1:exon
subclass of: SO_0000010

852667
type: Gene
SIO_000068: ncbigene

position:108158:1
position: 108158
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110404:1
position: 110404
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108158-110404:1:exon

YGL205W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FOX1
gene: POX1
locus tag: YGL205W
gene synonym: FOX1
product: acyl-CoA oxidase
transcript id: NM_001181070.1
SIO_010081: YGL205W
subclass of: SO_0000673
so part of: YGL205W
location: <108158..>110404
location: region:108158-110404:1
so has part: feature:108158-110404:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108158-110404:1:exon

YGL205W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FOX1
gene: POX1
locus tag: YGL205W
gene synonym: FOX1
EC number: 1.3.3.6
experiment: EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:11967269]
experiment: EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:12819196]
note: Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; component of a light sensing pathway, converting light into a hydrogen peroxide signal, modulating nucleo-cytoplasmic shuttling of stress-responsive transcription factor, Msn2p
codon start: 1
product: acyl-CoA oxidase
translation: MTRRTTINPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPERRTLTHALIDQIVNDPILKTDTDYYDAKKMQEREITAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASPLTNKDLFIFDKRLSLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKGIYGCFAMTELGHGSNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVEGKDYGVKTFVVPLRDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVRSPDGSVTVKTEPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQLIDYPLHQYRVLPQLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDSASLKATNTWLIATLIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATKGRFDNTLDVDSFSYLKPQYIGSVVSGEIKSGLKELGDYTEIWSITLIKLLAHIGTLVEKSRSIDSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITKESMWNVYKLFSLYFIDKHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAMLNSPIGYFDGDIYHNYFNEVCRNNPVEADGAGKPSYHALLSSMLGRGFEFDQKLGGAANAEILSKINK
SIO_010081: YGL205W
subclass of: SO_0000673
so part of: YGL205W
location: 108158..110404
location: region:108158-110404:1
so has part: feature:108158-110404:1:exon

NP_011310.1
type: Protein
SIO_000068: ncbiprotein

S000003173
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108158-110404:1:exon

YNCG0003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0003C
so part of: sequence
location: complement(110625..110696)
location: region:110625-110696:-1
so has part: feature:110625-110696:-1:exon
subclass of: SO_0000663

852668
type: Gene
SIO_000068: ncbigene

position:110625:-1
position: 110625
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:110696:-1
position: 110696
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110625-110696:-1:exon

YNCG0003C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0003C
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0003C
subclass of: SO_0000673
so part of: YNCG0003C
location: complement(110625..110696)
location: region:110625-110696:-1
so has part: feature:110625-110696:-1:exon

S000006595
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:110625-110696:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 110855..111225
location: region:110855-111225:1
so has part: feature:110855-111225:1:region

S000006950
type: SGD
SIO_000068: sgd

position:110855:1
position: 110855
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:111225:1
position: 111225
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:110855-111225:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(111226..111505)
location: region:111226-111505:-1
so has part: feature:111226-111505:-1:region

S000006935
type: SGD
SIO_000068: sgd

position:111226:-1
position: 111226
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:111505:-1
position: 111505
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111226-111505:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 111506..111698
location: region:111506-111698:1
so has part: feature:111506-111698:1:region

S000006940
type: SGD
SIO_000068: sgd

position:111506:1
position: 111506
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:111698:1
position: 111698
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111506-111698:1:region

YGL204C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL204C
so part of: sequence
location: complement(<111700..>112005)
location: region:111700-112005:-1
so has part: feature:111700-112005:-1:exon
subclass of: SO_0000010

852669
type: Gene
SIO_000068: ncbigene

position:111700:-1
position: 111700
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:112005:-1
position: 112005
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111700-112005:-1:exon

YGL204C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL204C
product: uncharacterized protein
transcript id: NM_001270746.1
SIO_010081: YGL204C
subclass of: SO_0000673
so part of: YGL204C
location: complement(<111700..>112005)
location: region:111700-112005:-1
so has part: feature:111700-112005:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111700-112005:-1:exon

YGL204C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL204C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; mRNA identified as translated by ribosome profiling data; protein identified via enrichment-based proteogenomics; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum
codon start: 1
product: uncharacterized protein
translation: MNGTDILRFLQSSPTISYSKHFILITACPLFVLGLLLLGLRTAMFKQVRGKTTTSRNRGVIAAKLLVAWYLATIVMYIAKSEMWKYAFAVSLLLNSLALFF
SIO_010081: YGL204C
subclass of: SO_0000673
so part of: YGL204C
location: complement(111700..112005)
location: region:111700-112005:-1
so has part: feature:111700-112005:-1:exon

NP_001257675.1
type: Protein
SIO_000068: ncbiprotein

S000003172
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111700-112005:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS704; Autonomously Replicating Sequence
so part of: sequence
location: 112079..112317
location: region:112079-112317:1
so has part: feature:112079-112317:1:region

S000118452
type: SGD
SIO_000068: sgd

position:112079:1
position: 112079
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:112317:1
position: 112317
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112079-112317:1:region

YGL203C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KEX1
locus tag: YGL203C
so part of: sequence
location: complement(<112475..>114664)
location: region:112475-114664:-1
so has part: feature:112475-114664:-1:exon
subclass of: SO_0000010

852670
type: Gene
SIO_000068: ncbigene

position:112475:-1
position: 112475
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:114664:-1
position: 114664
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:112475-114664:-1:exon

YGL203C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KEX1
locus tag: YGL203C
product: serine-type carboxypeptidase
transcript id: NM_001181068.1
SIO_010081: YGL203C
subclass of: SO_0000673
so part of: YGL203C
location: complement(<112475..>114664)
location: region:112475-114664:-1
so has part: feature:112475-114664:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:112475-114664:-1:exon

YGL203C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KEX1
locus tag: YGL203C
EC number: 3.4.16.6
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004185 serine-type carboxypeptidase activity [PMID:2668738]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]
experiment: EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:23656787]
note: Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
codon start: 1
product: serine-type carboxypeptidase
translation: MFYNRWLGTWLAMSALIRISVSLPSSEEYKVAYELLPGLSEVPDPSNIPQMHAGHIPLRSEDADEQDSSDLEYFFWKFTNNDSNGNVDRPLIIWLNGGPGCSSMDGALVESGPFRVNSDGKLYLNEGSWISKGDLLFIDQPTGTGFSVEQNKDEGKIDKNKFDEDLEDVTKHFMDFLENYFKIFPEDLTRKIILSGESYAGQYIPFFANAILNHNKFSKIDGDTYDLKALLIGNGWIDPNTQSLSYLPFAMEKKLIDESNPNFKHLTNAHENCQNLINSASTDEAAHFSYQECENILNLLLSYTRESSQKGTADCLNMYNFNLKDSYPSCGMNWPKDISFVSKFFSTPGVIDSLHLDSDKIDHWKECTNSVGTKLSNPISKPSIHLLPGLLESGIEIVLFNGDKDLICNNKGVLDTIDNLKWGGIKGFSDDAVSFDWIHKSKSTDDSEEFSGYVKYDRNLTFVSVYNASHMVPFDKSLVSRGIVDIYSNDVMIIDNNGKNVMITTDDDSDQDATTESGDKPKENLEEEEQEAQNEEGKEKEGNKDKDGDDDNDNDDDDEDDHNSEGDDDDDDDDDEDDNNEKQSNQGLEDSRHKSSEYEQEEEEVEEFAEEISMYKHKAVVVTIVTFLIVVLGVYAYDRRVRRKARHTILVDPNNRQHDSPNKTVSWADDLESGLGAEDDLEQDEQLEGGAPISSTSNKAGSKLKTKKKKKYTSLPNTEIDESFEMTDF
SIO_010081: YGL203C
subclass of: SO_0000673
so part of: YGL203C
location: complement(112475..114664)
location: region:112475-114664:-1
so has part: feature:112475-114664:-1:exon

NP_011312.1
type: Protein
SIO_000068: ncbiprotein

S000003171
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:112475-114664:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 114939..115269
location: region:114939-115269:1
so has part: feature:114939-115269:1:region

S000006941
type: SGD
SIO_000068: sgd

position:114939:1
position: 114939
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:115269:1
position: 115269
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:114939-115269:1:region

YNCG0004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0004W
so part of: sequence
location: 115488..115583
location: region:115488-115583:1
so has part: feature:115488-115583:1:exon
subclass of: SO_0000663

852671
type: Gene
SIO_000068: ncbigene

position:115488:1
position: 115488
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:115583:1
position: 115583
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:115488-115583:1:exon

YNCG0004W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0004W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCG0004W
subclass of: SO_0000673
so part of: YNCG0004W
location: join(115488..115524,115548..115583)
location: region:115488-115583:1
so has part: feature:115488-115524:1:exon
so has part: feature:115548-115583:1:exon

S000006630
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:115488-115524:1:exon

position:115524:1
position: 115524
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:115548-115583:1:exon

position:115548:1
position: 115548
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL202W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARO8
locus tag: YGL202W
so part of: sequence
location: <116059..>117561
location: region:116059-117561:1
so has part: feature:116059-117561:1:exon
subclass of: SO_0000010

852672
type: Gene
SIO_000068: ncbigene

position:116059:1
position: 116059
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:117561:1
position: 117561
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116059-117561:1:exon

YGL202W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARO8
locus tag: YGL202W
product: bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
transcript id: NM_001181067.1
SIO_010081: YGL202W
subclass of: SO_0000673
so part of: YGL202W
location: <116059..>117561
location: region:116059-117561:1
so has part: feature:116059-117561:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116059-117561:1:exon

YGL202W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARO8
locus tag: YGL202W
EC number: 2.6.1.39
EC number: 2.6.1.57
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]
experiment: EXISTENCE:genetic interaction:GO:0006571 tyrosine biosynthetic process [PMID:9491082]
experiment: EXISTENCE:genetic interaction:GO:0009094 L-phenylalanine biosynthetic process [PMID:9491082]
experiment: EXISTENCE:mutant phenotype:GO:0008793 aromatic-amino-acid:2-oxoglutarate aminotransferase activity [PMID:9491082]
experiment: EXISTENCE:mutant phenotype:GO:0009072 aromatic amino acid metabolic process [PMID:9491083]
experiment: EXISTENCE:mutant phenotype:GO:0047536 2-aminoadipate transaminase activity [PMID:9491082]
note: Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; involved with Aro9p in production of kynurenic acid to detoxify excess tryptophan
codon start: 1
product: bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase
translation: MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK
SIO_010081: YGL202W
subclass of: SO_0000673
so part of: YGL202W
location: 116059..117561
location: region:116059-117561:1
so has part: feature:116059-117561:1:exon

NP_011313.1
type: Protein
SIO_000068: ncbiprotein

S000003170
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116059-117561:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS706; Autonomously Replicating Sequence
so part of: sequence
location: 117561..117854
location: region:117561-117854:1
so has part: feature:117561-117854:1:region

S000114845
type: SGD
SIO_000068: sgd

position:117854:1
position: 117854
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117561-117854:1:region

YGL201C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCM6
locus tag: YGL201C
so part of: sequence
location: complement(<117854..>120907)
location: region:117854-120907:-1
so has part: feature:117854-120907:-1:exon
subclass of: SO_0000010

852673
type: Gene
SIO_000068: ncbigene

position:117854:-1
position: 117854
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:120907:-1
position: 120907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117854-120907:-1:exon

YGL201C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCM6
locus tag: YGL201C
product: MCM DNA helicase complex subunit MCM6
transcript id: NM_001181066.1
SIO_010081: YGL201C
subclass of: SO_0000673
so part of: YGL201C
location: complement(<117854..>120907)
location: region:117854-120907:-1
so has part: feature:117854-120907:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:117854-120907:-1:exon

YGL201C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCM6
locus tag: YGL201C
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15723534]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10704410]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0006268 DNA unwinding involved in DNA replication [PMID:15723534|PMID:13679365]
experiment: EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:13679365]
experiment: EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:15723534|PMID:18657510]
experiment: EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]
experiment: EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:13679365]
experiment: EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]
experiment: EXISTENCE:direct assay:GO:0097373 MCM core complex [PMID:13679365]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]
note: Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
codon start: 1
product: MCM DNA helicase complex subunit MCM6
translation: MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGPFVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGNGTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSSTLDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRETELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDVDDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKKKTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRLAFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS
SIO_010081: YGL201C
subclass of: SO_0000673
so part of: YGL201C
location: complement(117854..120907)
location: region:117854-120907:-1
so has part: feature:117854-120907:-1:exon

NP_011314.2
type: Protein
SIO_000068: ncbiprotein

S000003169
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117854-120907:-1:exon

YNCG0005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0005W
so part of: sequence
location: 122269..122341
location: region:122269-122341:1
so has part: feature:122269-122341:1:exon
subclass of: SO_0000663

852674
type: Gene
SIO_000068: ncbigene

position:122269:1
position: 122269
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:122341:1
position: 122341
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122269-122341:1:exon

YNCG0005W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0005W
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCG0005W
subclass of: SO_0000673
so part of: YNCG0005W
location: 122269..122341
location: region:122269-122341:1
so has part: feature:122269-122341:1:exon

S000006621
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122269-122341:1:exon

YGL200C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BST2
gene: EMP24
locus tag: YGL200C
gene synonym: BST2
so part of: sequence
location: complement(<122694..>123305)
location: region:122694-123305:-1
so has part: feature:122694-123305:-1:exon
subclass of: SO_0000010

852675
type: Gene
SIO_000068: ncbigene

position:122694:-1
position: 122694
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:123305:-1
position: 123305
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122694-123305:-1:exon

YGL200C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BST2
gene: EMP24
locus tag: YGL200C
gene synonym: BST2
product: Emp24p
transcript id: NM_001181065.3
SIO_010081: YGL200C
subclass of: SO_0000673
so part of: YGL200C
location: complement(<122694..>123305)
location: region:122694-123305:-1
so has part: feature:122694-123305:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122694-123305:-1:exon

YGL200C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BST2
gene: EMP24
locus tag: YGL200C
gene synonym: BST2
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8862519]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:8862519]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8862519]
experiment: EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:8862519]
note: Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
codon start: 1
product: Emp24p
translation: MASFATKFVIACFLFFSASAHNVLLPAYGRRCFFEDLSKGDELSISFQFGDRNPQSSSQLTGDFIIYGPERHEVLKTVRDTSHGEITLSAPYKGHFQYCFLNENTGIETKDVTFNIHGVVYVDLDDPNTNTLDSAVRKLSKLTREVKDEQSYIVIRERTHRNTAESTNDRVKWWSIFQLGVVIANSLFQIYYLRRFFEVTSLV
SIO_010081: YGL200C
subclass of: SO_0000673
so part of: YGL200C
location: complement(122694..123305)
location: region:122694-123305:-1
so has part: feature:122694-123305:-1:exon

NP_011315.3
type: Protein
SIO_000068: ncbiprotein

S000003168
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122694-123305:-1:exon

YGL198W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YIP4
locus tag: YGL198W
so part of: sequence
location: <123591..>124298
location: region:123591-124298:1
so has part: feature:123591-124298:1:exon
subclass of: SO_0000010

852676
type: Gene
SIO_000068: ncbigene

position:123591:1
position: 123591
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:124298:1
position: 124298
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123591-124298:1:exon

YGL198W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YIP4
locus tag: YGL198W
product: Yip4p
transcript id: NM_001181063.1
SIO_010081: YGL198W
subclass of: SO_0000673
so part of: YGL198W
location: <123591..>124298
location: region:123591-124298:1
so has part: feature:123591-124298:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:123591-124298:1:exon

YGL198W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YIP4
locus tag: YGL198W
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17178117]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11943201]
note: Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
codon start: 1
product: Yip4p
translation: MSYGREDTTIEPDFIEPDAPLAASGGVADNIGGTMQNSGSRGTLDETVLQTLKRDVVEINSRLKQVVYPHFPSFFSPSDDGIGAADNDISANCDLWAPLAFIILYSLFVSHARSLFSSLFVSSWFILLVMALHLRLTKPHQRVSLISYISISGYCLFPQVLNALVSQILLPLAYHIGKQNRWIVRVLSLVKLVVMALCLMWSVAAVSWVTKSKTIIEIYPLALCLFGMAWLSTIL
SIO_010081: YGL198W
subclass of: SO_0000673
so part of: YGL198W
location: 123591..124298
location: region:123591-124298:1
so has part: feature:123591-124298:1:exon

NP_011317.2
type: Protein
SIO_000068: ncbiprotein

S000003166
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:123591-124298:1:exon

YGL197W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MDS3
locus tag: YGL197W
so part of: sequence
location: <124698..>129161
location: region:124698-129161:1
so has part: feature:124698-129161:1:exon
subclass of: SO_0000010

852678
type: Gene
SIO_000068: ncbigene

position:124698:1
position: 124698
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:129161:1
position: 129161
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:124698-129161:1:exon

YGL197W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MDS3
locus tag: YGL197W
product: Mds3p
transcript id: NM_001181062.2
SIO_010081: YGL197W
subclass of: SO_0000673
so part of: YGL197W
location: <124698..>129161
location: region:124698-129161:1
so has part: feature:124698-129161:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124698-129161:1:exon

YGL197W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MDS3
locus tag: YGL197W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0075297 negative regulation of ascospore formation [PMID:9383076]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]
experiment: EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:20457806]
experiment: EXISTENCE:mutant phenotype:GO:0075297 negative regulation of ascospore formation [PMID:9383076]
note: Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication
codon start: 1
product: Mds3p
translation: MPLLQPSTCFCYPLKLPPLPLTSDSNEFDECARKRLTLDYRTGSAVTLTRSNIFVHGGLTIPLNLPVVNSMQLQKELILFFAKEKNNGSSFRNLNEWISKETFFLDLMSRTWYRVKTSFDQRTEELLKAESSSAKADNDTNEIRTDIKKGKSLESPLKERLFHSLCYLDGCLYIFGGLTVSPQSGYELIATNELWKLDLNTKKWSLLSDDPQIARRFNHTMHVKNENNDNRDTKLIIVGGLNNMDQPVKKIDIYNISQNCWQSETIPKQPMEITTNVNGIPLALSKDQNFSILVENNEANVPALAFYMRSDQIDEYLGKDSSKIKENSPIVALPLLSESQGIRMPSNPALPKKLLNVPYELLAPTGDYFGFNIIIGGFHPNYQSSNFHCFIYDINSGKWSRVATACPDCDINKHRFWRVFVWKSHHQTILLGTKTDDYYSPSVQRFDHLSTFGLPLVNIFNKTIQLPHHKISASSLPIPIENFAKHKDTPLKKVSFTSSATSQFENYIRYIAPPLEMSSIQSVFPPYAMVLGKDALEIYGKPLSDFEFITSEGDSIGIPCYLLRKRWGRYFDMLLSQSYTKVCADYETTDTQSTLIKFSPHSSRNSSKAVRQEGRLSSSGSLDNYFEKNFPIFARTSVSEAQNTQPQVANADAKAPNTPSTSDEPSSSSSSDLYSTPHYQRNNDEEDDEDPVSPKPVSKSNSIYRPIRKTESSSTTSSSNGMIFRVPFKEKAAVTSNTEALLESNLSLQELSRRRSSLMSIPSGELLRSSISEAEHQRRASHPLTSSPLFEDSGTPCGKQLQQLQQHTIQNPHNHLSPRRFSRSARSSISYVSSSSDRRGNSISSRSTSDSFGTPPVLGVLNVPLPPQTREPNEPPPPCPAMSTGSNTRRSNTLTDYMHSNKASPFSSRRSSHIGRRSSTPETENAFSATPRASLDGQMLGKSLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNTDSFDSLQSNFALELEPLLTPRSLYMPWPTSTVRAFAEFFYTGQVNSKWLLAPVALDLLVMAKIYEIPLLYKLILEVLYSILAKKEESLSLICTSLMETFRTKTLNSYKGDEEKTNTYLTSNDNYQELLKLKVSLENIDNGYYDPDLLRKQSRAQSSSTQESSGSANGEKTATGAGSLETSSTNVPTVFAGGPRDSHNSVGSIGFPNSMNIQGSRRSTSGFSPRVKMKSSLSKEIDPKTFYEEYEPKEGKSFDDNDDQQTNIGSFNLHLFDMNYGSISSSSTNSISSSDLEEKEEQEQLQDLLEIEREDSAEILDARFRNKEDDKVTKDISNDKKRNYLPHEKNNLKAKEGKETRDVREEEEEFDFGLGMLSLNKIKREAKHVDKVDDSVDPLFKSSAFPQSPIRAYGSTTRTSSASGKPFRDNRSFNAFSVLTLENMASANALPPVDYVIKSIYRTTVLVNDIRLMVRCMDCIELSKNLRALKKKTMEDISKLKGISKPSP
SIO_010081: YGL197W
subclass of: SO_0000673
so part of: YGL197W
location: 124698..129161
location: region:124698-129161:1
so has part: feature:124698-129161:1:exon

NP_011318.2
type: Protein
SIO_000068: ncbiprotein

S000003165
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124698-129161:1:exon

YGL196W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DSD1
locus tag: YGL196W
so part of: sequence
location: <129883..>131169
location: region:129883-131169:1
so has part: feature:129883-131169:1:exon
subclass of: SO_0000010

852679
type: Gene
SIO_000068: ncbigene

position:129883:1
position: 129883
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:131169:1
position: 131169
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:129883-131169:1:exon

YGL196W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DSD1
locus tag: YGL196W
product: D-serine ammonia-lyase DSD1
transcript id: NM_001181061.1
SIO_010081: YGL196W
subclass of: SO_0000673
so part of: YGL196W
location: <129883..>131169
location: region:129883-131169:1
so has part: feature:129883-131169:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:129883-131169:1:exon

YGL196W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DSD1
locus tag: YGL196W
EC number: 4.3.1.18
experiment: EXISTENCE:direct assay:GO:0008721 D-serine ammonia-lyase activity [PMID:17937657|PMID:17869212]
experiment: EXISTENCE:mutant phenotype:GO:0070178 D-serine metabolic process [PMID:17937657]
note: D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
codon start: 1
product: D-serine ammonia-lyase DSD1
translation: MSDVLSQYKGCSVRDLPTPNFVINEEKFDKNCTTMLNNVEKLSQECGVPIKFRAHVKTHKTAKGTLKQLGHGLPLAKRTTRAILVSTLKEAEELLNYQDRQCSDYIDDITYSLPCCVPEFIPLLSNLSRRVNNFQVFVDNIEHLENLKNFGRPASGKKWSVFIKVDMGTKRAGLAFDSPEFLSLLKKLTSSEIKEVIEPYGFYAHAGHSYSSTSINDTQNLLMEEVKAVNSAAKVLCSVDPQFDPSKLTLSVGATPTSNSLKLDNKSTLVKFITTQLVSTLEIHCGNYCMYDLQQVATGCVQDHELSGFVLGTVLSSYPSRGELLSNTGVMCLTREASSIKGFGICADLEHVLKSESFSREWYVARVSQEHGILRPIRNWNETTPLKLGSKIAVLPQHACITMGQFPYYFVVNSEGIVNDVWLPFQKW
SIO_010081: YGL196W
subclass of: SO_0000673
so part of: YGL196W
location: 129883..131169
location: region:129883-131169:1
so has part: feature:129883-131169:1:exon

NP_011319.2
type: Protein
SIO_000068: ncbiprotein

S000003164
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:129883-131169:1:exon

YGL195W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAS103
alternative label: NDR1
gene: GCN1
locus tag: YGL195W
gene synonym: AAS103; NDR1
so part of: sequence
location: <131525..>139543
location: region:131525-139543:1
so has part: feature:131525-139543:1:exon
subclass of: SO_0000010

852680
type: Gene
SIO_000068: ncbigene

position:131525:1
position: 131525
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139543:1
position: 139543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131525-139543:1:exon

YGL195W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAS103
alternative label: NDR1
gene: GCN1
locus tag: YGL195W
gene synonym: AAS103; NDR1
product: Gcn1p
transcript id: NM_001181060.3
SIO_010081: YGL195W
subclass of: SO_0000673
so part of: YGL195W
location: <131525..>139543
location: region:131525-139543:1
so has part: feature:131525-139543:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:131525-139543:1:exon

YGL195W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAS103
alternative label: NDR1
gene: GCN1
locus tag: YGL195W
gene synonym: AAS103; NDR1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9234705]
experiment: EXISTENCE:direct assay:GO:0016239 positive regulation of macroautophagy [PMID:28057755]
experiment: EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:9234705]
experiment: EXISTENCE:mutant phenotype:GO:0006448 regulation of translational elongation [PMID:9234705]
experiment: EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11101534]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:28057755]
note: Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes
codon start: 1
product: Gcn1p
translation: MTAILNWEDISPVLEKGTRESHVSKRVPFLQDISQLVRQETLEKPQLSEIAFVLLNTFTIYEDNRSKSLVTSILLDILNLEPCLLENFIRFISDVVISNPATKAVADYLNLLDWINSFLIFVSHNSNLFEEYIPKLLVAHSYATFGVETILDNQEEGKKSQDKQNQHRKRIRYCIFQTTVKAFLKCLKDNDDSISFMKISIKTVLESYSKLKITSVGVVMIMGALTQAALQLLSRQPALHSVLKENSAEKYCEYLGKEVFLGKNPPSSFCLEIGLKPFLKEFVSQELFIKFFIPNIEKAVLRSPEVGFSILSELYAGVSPEKVNLLNAFASSKLINQYFSSFKSSKEVVRSVSLQSMIILLRKISNTDTTLEDLTKLIDEIFKNIKSNLNADYKSLISKILIEIPLTHYEVSEKICKGLSPYIGKEGNEAALTLMLNAFFVHYFSLGKPIEDLDKIISAGFADKKPALKKCWFAAFLNNSNAASEEVILNFIDGCLEFVKDSIIHYQTHGHACILASIEFTNKILALDNTELNDRVMQLIETLPENSSIGDAILTAALSTELSIENRIHAVNLLQELFYKKPEFIGFSVIDAIERRMRVQELIPQQNTSFKYVTSVLLAITSELPDKEASIKVLINALVIAQWNIFNIKNGWAGLVLRARLDPAEVVKEHASVIMEKILEITGSCEWIDTIYGACGLQAAAYAAFIQPNEFTPILCKTIEADLTADDFSRLSEEDFEIFAGEEGVLVVDVLEESMNKKLSNKNSKEYETLMWEQKIRKEQAKKNVKKLSKEEQELVNEQLAKESAVRSHVSEISTRLKRGIRLVSELSKAACLVQNGIATWFPLAVTKLLYLCSEPNISKLTEDVNNVFLQLSQNVSERLGNIRLFLGLATLRVHNANGISQDYLQEPLVELLTRVLFRIKFVSNQAAIDSISLTYILPLLINVLEKGKAIALKNADKPVVKAEFVEEDEEEEHLLLAMEIISVHAEAFEDPSIPRISIVEVLLSLLSLPSKAKIAKDCFNALCQSISVAPNQEDLDMILSNLLSPNQFVRSTILETLDNEFELEPFMKYSPEVFICRFDSDPSNREIADFIWEFNKFVVNDELLKSLFPLFNQDDSGLRLFAANAYAFGAVSLFTSEENSSKDYLNDLLNFYKEKAKPLEPILDQFGLVLVSASEQKDPWQGRSTVAITLKIMAKAFSAEDDTVVNIIKFLVDDGGLVDREPIVRQEMKEAGVELITLHGSQNSKDLIPIFEEALSSSTDSALKENVIILYGTLARHLQQSDARIHTIIERLLSTLDTPSADIQQAVSACIAPLVFQFKQKVGDYLGILMEKLLNPTVASSMRKGAAWGIAGLVKGYGISALSEFDIIRNLIEAAEDKKEPKRRESVGFCFQYLSESLGKFFEPYVIEILPNILKNLGDAVPEVRDATARATKAIMAHTTGYGVKKLIPVAVSNLDEIAWRTKRGSVQLLGNMAYLDPTQLSASLSTIVPEIVGVLNDSHKEVRKAADESLKRFGEVIRNPEIQKLVPVLLQAIGDPTKYTEEALDSLIQTQFVHYIDGPSLALIIHIIHRGMHDRSANIKRKACKIVGNMAILVDTKDLIPYLQQLIDEVEIAMVDPVPNTRATAARALGALVERLGEEQFPDLIPRLLDTLSDESKSGDRLGSAQALAEVISGLGLTKLDEMLPTILAGVTNFRAYIREGFMPLLLFLPVCFGSQFAPYINQIIQPILSGLADNDENIRDTALKAGKLIVKNYATKAVDLLLPELERGMFDENDRIRLSSVQLTGELLFQVTGISSRNEFSEEDGDHNGEFSGKLVDVLGQDRRDRILAALFVCRNDTSGIVRATTVDIWKALVPNTPRAVKEILPTLTGMIVTHLASSSNVLRNIAAQTLGDLVRRVGGNALSQLLPSLEESLIETSNSDSRQGVCIALYELIESASTETISQFQSTIVNIIRTALIDESATVREAAALSFDVFQDVVGKTAVDEVLPYLLHMLES…
SIO_010081: YGL195W
subclass of: SO_0000673
so part of: YGL195W
location: 131525..139543
location: region:131525-139543:1
so has part: feature:131525-139543:1:exon

NP_011320.3
type: Protein
SIO_000068: ncbiprotein

S000003163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131525-139543:1:exon

YGL194C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL194C-A
so part of: sequence
location: complement(<139719..>139961)
location: region:139719-139961:-1
so has part: feature:139719-139961:-1:exon
subclass of: SO_0000010

3799973
type: Gene
SIO_000068: ncbigene

position:139719:-1
position: 139719
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139961:-1
position: 139961
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139719-139961:-1:exon

YGL194C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL194C-A
product: uncharacterized protein
transcript id: NM_001184677.1
SIO_010081: YGL194C-A
subclass of: SO_0000673
so part of: YGL194C-A
location: complement(<139719..>139961)
location: region:139719-139961:-1
so has part: feature:139719-139961:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:139719-139961:-1:exon

YGL194C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL194C-A
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum
codon start: 1
product: uncharacterized protein
translation: MSNKEITCIKPFKIIALILLIVLIINLSYKLFLRRYLKSTVIWCLGIANTDRNDMMWWQVSPLLERWVWQLVDNYESGYE
SIO_010081: YGL194C-A
subclass of: SO_0000673
so part of: YGL194C-A
location: complement(139719..139961)
location: region:139719-139961:-1
so has part: feature:139719-139961:-1:exon

NP_001032578.1
type: Protein
SIO_000068: ncbiprotein

S000087160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:139719-139961:-1:exon

YGL194C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RTL1
gene: HOS2
locus tag: YGL194C
gene synonym: RTL1
so part of: sequence
location: complement(<140368..>141726)
location: region:140368-141726:-1
so has part: feature:140368-141726:-1:exon
subclass of: SO_0000010

852681
type: Gene
SIO_000068: ncbigene

position:140368:-1
position: 140368
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:141726:-1
position: 141726
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140368-141726:-1:exon

YGL194C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RTL1
gene: HOS2
locus tag: YGL194C
gene synonym: RTL1
product: histone deacetylase HOS2
transcript id: NM_001181059.1
SIO_010081: YGL194C
subclass of: SO_0000673
so part of: YGL194C
location: complement(<140368..>141726)
location: region:140368-141726:-1
so has part: feature:140368-141726:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140368-141726:-1:exon

YGL194C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RTL1
gene: HOS2
locus tag: YGL194C
gene synonym: RTL1
EC number: 3.5.1.98
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]
experiment: EXISTENCE:direct assay:GO:0045129 NAD-independent histone deacetylase activity [PMID:11711434]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]
experiment: EXISTENCE:mutant phenotype:GO:0032874 positive regulation of stress-activated MAPK cascade [PMID:18487345]
experiment: EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:11711434]
note: Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
codon start: 1
product: histone deacetylase HOS2
translation: MSGTFSYDVKTKENEPLFEFNSAYSPRVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKLPRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLINNQSDIAINWSGGLHHAKKNSPSGFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFHKYNGEFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIVQQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYTPRNVSRLWTYETGILNDVLLPEDIPEDIPFRDSFGPDYSLYPMLDDLYENKNSKKLLEDIRIRCLENIRYLQGAPSVRMDAECIPTQDISALTEEEDKIIQEMNEETEADSSNRLEEMEKENSGLIAFS
SIO_010081: YGL194C
subclass of: SO_0000673
so part of: YGL194C
location: complement(140368..141726)
location: region:140368-141726:-1
so has part: feature:140368-141726:-1:exon

NP_011321.1
type: Protein
SIO_000068: ncbiprotein

S000003162
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140368-141726:-1:exon

YNCG0006C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RME2
locus tag: YNCG0006C
so part of: sequence
location: complement(141898..144120)
location: region:141898-144120:-1
so has part: feature:141898-144120:-1:exon
subclass of: SO_0000011

23547380
type: Gene
SIO_000068: ncbigene

position:141898:-1
position: 141898
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:144120:-1
position: 144120
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141898-144120:-1:exon

YNCG0006C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: antisense_RNA
gene: RME2
locus tag: YNCG0006C
product: RME2
note: Antisense transcript initiated from the 3' end of the IME4 locus; expressed in haploids and interferes with IME4 expression through a cis-acting mechanism; RME2 expression is repressed by the MAT a1/alpha2 repressor complex
transcript id: NR_132177.1
SIO_010081: YNCG0006C
subclass of: SO_0000673
so part of: YNCG0006C
location: complement(141898..144120)
location: region:141898-144120:-1
so has part: feature:141898-144120:-1:exon

S000144908
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141898-144120:-1:exon

YGL193C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL193C
so part of: sequence
location: complement(<141916..>142227)
location: region:141916-142227:-1
so has part: feature:141916-142227:-1:exon
subclass of: SO_0000010

852682
type: Gene
SIO_000068: ncbigene

position:141916:-1
position: 141916
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:142227:-1
position: 142227
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141916-142227:-1:exon

YGL193C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL193C
product: uncharacterized protein
transcript id: NM_001181058.1
SIO_010081: YGL193C
subclass of: SO_0000673
so part of: YGL193C
location: complement(<141916..>142227)
location: region:141916-142227:-1
so has part: feature:141916-142227:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141916-142227:-1:exon

YGL193C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL193C
note: Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
codon start: 1
product: uncharacterized protein
translation: MNSSLNANSYFFRKPPMLTYMVRFLYCYPSPFPIAPAVTDLPECRGDLSLSLFITSFTSTKERTILYAKSRLKTHIPVNLCDRYHYIPKAPLYQCRMPCLYSI
SIO_010081: YGL193C
subclass of: SO_0000673
so part of: YGL193C
location: complement(141916..142227)
location: region:141916-142227:-1
so has part: feature:141916-142227:-1:exon

NP_011322.1
type: Protein
SIO_000068: ncbiprotein

S000003161
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141916-142227:-1:exon

YGL192W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPO8
gene: IME4
locus tag: YGL192W
gene synonym: SPO8
so part of: sequence
location: <142246..>144048
location: region:142246-144048:1
so has part: feature:142246-144048:1:exon
subclass of: SO_0000010

852683
type: Gene
SIO_000068: ncbigene

position:142246:1
position: 142246
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:144048:1
position: 144048
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:142246-144048:1:exon

YGL192W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPO8
gene: IME4
locus tag: YGL192W
gene synonym: SPO8
product: mRNA (N6-adenosine)-methyltransferase
transcript id: NM_001181057.3
SIO_010081: YGL192W
subclass of: SO_0000673
so part of: YGL192W
location: <142246..>144048
location: region:142246-144048:1
so has part: feature:142246-144048:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:142246-144048:1:exon

YGL192W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPO8
gene: IME4
locus tag: YGL192W
gene synonym: SPO8
EC number: 2.1.1.348
experiment: EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]
experiment: EXISTENCE:genetic interaction:GO:0080009 mRNA methylation [PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:0001734 mRNA (N6-adenosine)-methyltransferase activity [PMID:12384598]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:1545790|PMID:12384598|PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:0080009 mRNA methylation [PMID:12384598|PMID:22685417]
experiment: EXISTENCE:mutant phenotype:GO:1902974 meiotic DNA replication initiation [PMID:31363087]
experiment: EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]
note: mRNA N6-adenosine methyltransferase; essential for meiosis in S288C but dispensable for meiosis in SK1, mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70)
codon start: 1
product: mRNA (N6-adenosine)-methyltransferase
translation: MINDKLVHFLIQNYDDILRAPLSGQLKDVYSLYISGGYDDEMQKLRNDKDEVLQFEQFWNDLQDIIFATPQSIQFDQNLLVADRPEKIVYLDVFSLKILYNKFHAFYYTLKSSSSSCEEKVSSLTTKPEADSEKDQLLGRLLGVLNWDVNVSNQGLPREQLSNRLQNLLREKPSSFQLAKERAKYTTEVIEYIPICSDYSHASLLSTSVYIVNNKIVSLQWSKISACQENHPGLIECIQSKIHFIPNIKPQTDISLGDCSYLDTCHKLNTCRYIHYLQYIPSCLQERADRETASENKRIRSNVSIPFYTLGNCSAHCIKKALPAQWIRCDVRKFDFRVLGKFSVVIADPAWNIHMNLPYGTCNDIELLGLPLHELQDEGIIFLWVTGRAIELGKESLNNWGYNVINEVSWIKTNQLGRTIVTGRTGHWLNHSKEHLLVGLKGNPKWINKHIDVDLIVSMTRETSRKPDELYGIAERLAGTHARKLEIFGRDHNTRPGWFTIGNQLTGNCIYEMDVERKYQEFMKSKTGTSHTGTKKIDKKQPSKLQQQHQQQYWNNMDMGSGKYYAEAKQNPMNQKHTPFESKQQQKQQFQTLNNLYFAQ
SIO_010081: YGL192W
subclass of: SO_0000673
so part of: YGL192W
location: 142246..144048
location: region:142246-144048:1
so has part: feature:142246-144048:1:exon

NP_011323.3
type: Protein
SIO_000068: ncbiprotein

S000003160
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:142246-144048:1:exon

YGL191W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX13
locus tag: YGL191W
so part of: sequence
location: <144808..>145197
location: region:144808-145197:1
so has part: feature:144808-145197:1:exon
subclass of: SO_0000010

852684
type: Gene
SIO_000068: ncbigene

position:144808:1
position: 144808
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145197:1
position: 145197
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144808-145197:1:exon

YGL191W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX13
locus tag: YGL191W
product: cytochrome c oxidase subunit VIa
transcript id: NM_001181056.1
SIO_010081: YGL191W
subclass of: SO_0000673
so part of: YGL191W
location: <144808..>145197
location: region:144808-145197:1
so has part: feature:144808-145197:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:144808-145197:1:exon

YGL191W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX13
locus tag: YGL191W
experiment: EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24478450|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10429195]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8395517]
experiment: EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:22342701]
note: Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
codon start: 1
product: cytochrome c oxidase subunit VIa
translation: MFRQCAKRYASSLPPNALKPAFGPPDKVAAQKFKESLMATEKHAKDTSNMWVKISVWVALPAIALTAVNTYFVEKEHAEHREHLKHVPDSEWPRDYEFMNIRSKPFFWGDGDKTLFWNPVVNRHIEHDD
SIO_010081: YGL191W
subclass of: SO_0000673
so part of: YGL191W
location: 144808..145197
location: region:144808-145197:1
so has part: feature:144808-145197:1:exon

NP_011324.1
type: Protein
SIO_000068: ncbiprotein

S000003159
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:144808-145197:1:exon

YGL190C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TMR4
gene: CDC55
locus tag: YGL190C
gene synonym: TMR4
so part of: sequence
location: complement(<145809..>147389)
location: region:145809-147389:-1
so has part: feature:145809-147389:-1:exon
subclass of: SO_0000010

852685
type: Gene
SIO_000068: ncbigene

position:145809:-1
position: 145809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147389:-1
position: 147389
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145809-147389:-1:exon

YGL190C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TMR4
gene: CDC55
locus tag: YGL190C
gene synonym: TMR4
product: protein phosphatase 2A regulatory subunit CDC55
transcript id: NM_001181055.1
SIO_010081: YGL190C
subclass of: SO_0000673
so part of: YGL190C
location: complement(<145809..>147389)
location: region:145809-147389:-1
so has part: feature:145809-147389:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145809-147389:-1:exon

YGL190C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TMR4
gene: CDC55
locus tag: YGL190C
gene synonym: TMR4
experiment: EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12388751]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12388751]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21536748]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12388751]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12388751]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12388751]
experiment: EXISTENCE:genetic interaction:GO:0019888 protein phosphatase regulator activity [PMID:17550305]
experiment: EXISTENCE:genetic interaction:GO:0044818 mitotic G2/M transition checkpoint [PMID:20980617]
experiment: EXISTENCE:genetic interaction:GO:0045143 homologous chromosome segregation [PMID:27455870]
experiment: EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]
experiment: EXISTENCE:mutant phenotype:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]
experiment: EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:16314395]
experiment: EXISTENCE:mutant phenotype:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:21536748]
experiment: EXISTENCE:mutant phenotype:GO:0016237 lysosomal microautophagy [PMID:32029270]
experiment: EXISTENCE:mutant phenotype:GO:0061586 positive regulation of transcription by transcription factor localization [PMID:23275436]
experiment: EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:23886942|PMID:27191586]
experiment: EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:23275436]
experiment: EXISTENCE:mutant phenotype:GO:1905477 positive regulation of protein localization to membrane [PMID:32029270]
note: Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p in early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; controls phosphorylation and stability of Cln2p; homolog of mammalian B55
codon start: 1
product: protein phosphatase 2A regulatory subunit CDC55
translation: MAQNNFDFKFSQCFGDKADIVVTEADLITAVEFDYTGNYLATGDKGGRVVLFERSNSRHCEYKFLTEFQSHDAEFDYLKSLEIEEKINEIKWLRPTQRSHFLLSTNDKTIKLWKVYEKNIKLVSQNNLTEGVTFAKKGKPDNHNSRGGSVRAVLSLQSLKLPQLSQHDKIIAATPKRIYSNAHTYHINSISLNSDQETFLSADDLRINLWNLDIPDQSFNIVDIKPTNMEELTEVITSAEFHPQECNLFMYSSSKGTIKLCDMRQNSLCDNKTKTFEEYLDPINHNFFTEITSSISDIKFSPNGRYIASRDYLTVKIWDVNMDNKPLKTINIHEQLKERLSDTYENDAIFDKFEVNFSGDSSSVMTGSYNNNFMIYPNVVTSGDNDNGIVKTFDEHNAPNSNSNKNIHNSIQNKDSSSSGNSHKRRSNGRNTGMVGSSNSSRSSIAGGEGANSEDSGTEMNEIVLQADKTAFRNKRYGSLAQRSARNKDWGDDIDFKKNILHFSWHPRENSIAVAATNNLFIFSAL
SIO_010081: YGL190C
subclass of: SO_0000673
so part of: YGL190C
location: complement(145809..147389)
location: region:145809-147389:-1
so has part: feature:145809-147389:-1:exon

NP_011325.1
type: Protein
SIO_000068: ncbiprotein

S000003158
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145809-147389:-1:exon

YGL189C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS26
gene: RPS26A
locus tag: YGL189C
gene synonym: RPS26
so part of: sequence
location: complement(<148229..>148588)
location: region:148229-148588:-1
so has part: feature:148229-148588:-1:exon
subclass of: SO_0000010

852686
type: Gene
SIO_000068: ncbigene

position:148229:-1
position: 148229
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148588:-1
position: 148588
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148229-148588:-1:exon

YGL189C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS26
gene: RPS26A
locus tag: YGL189C
gene synonym: RPS26
product: ribosomal 40S subunit protein S26A
transcript id: NM_001181054.1
SIO_010081: YGL189C
subclass of: SO_0000673
so part of: YGL189C
location: complement(<148229..>148588)
location: region:148229-148588:-1
so has part: feature:148229-148588:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148229-148588:-1:exon

YGL189C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS26
gene: RPS26A
locus tag: YGL189C
gene synonym: RPS26
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25144938]
experiment: EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:27303706]
experiment: EXISTENCE:physical interaction:GO:0030686 90S preribosome [PMID:25144938]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia
codon start: 1
product: ribosomal 40S subunit protein S26A
translation: MPKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIVEAAAVRDLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPPQRPRFNRENKVSPADAAKKAL
SIO_010081: YGL189C
subclass of: SO_0000673
so part of: YGL189C
location: complement(148229..148588)
location: region:148229-148588:-1
so has part: feature:148229-148588:-1:exon

NP_011326.1
type: Protein
SIO_000068: ncbiprotein

S000003157
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148229-148588:-1:exon

YGL188C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL188C-A
so part of: sequence
location: complement(<148824..>148964)
location: region:148824-148964:-1
so has part: feature:148824-148964:-1:exon
subclass of: SO_0000010

1466453
type: Gene
SIO_000068: ncbigene

position:148824:-1
position: 148824
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148964:-1
position: 148964
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148824-148964:-1:exon

YGL188C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL188C-A
product: uncharacterized protein
transcript id: NM_001184593.3
SIO_010081: YGL188C-A
subclass of: SO_0000673
so part of: YGL188C-A
location: complement(<148824..>148964)
location: region:148824-148964:-1
so has part: feature:148824-148964:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148824-148964:-1:exon

YGL188C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL188C-A
codon start: 1
product: uncharacterized protein
translation: MLTTQKCESREGKNDEIFELGESNSDKILLKHGKCNLFSERKPVNH
SIO_010081: YGL188C-A
subclass of: SO_0000673
so part of: YGL188C-A
location: complement(148824..148964)
location: region:148824-148964:-1
so has part: feature:148824-148964:-1:exon

NP_878073.3
type: Protein
SIO_000068: ncbiprotein

S000028635
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148824-148964:-1:exon

YGL187C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX4
locus tag: YGL187C
so part of: sequence
location: complement(<149704..>150171)
location: region:149704-150171:-1
so has part: feature:149704-150171:-1:exon
subclass of: SO_0000010

852688
type: Gene
SIO_000068: ncbigene

position:149704:-1
position: 149704
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150171:-1
position: 150171
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:149704-150171:-1:exon

YGL187C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX4
locus tag: YGL187C
product: cytochrome c oxidase subunit IV
transcript id: NM_001181052.1
SIO_010081: YGL187C
subclass of: SO_0000673
so part of: YGL187C
location: complement(<149704..>150171)
location: region:149704-150171:-1
so has part: feature:149704-150171:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:149704-150171:-1:exon

YGL187C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX4
locus tag: YGL187C
experiment: EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24478450|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:17215247]
note: Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation
codon start: 1
product: cytochrome c oxidase subunit IV
translation: MLSLRQSIRFFKPATRTLCSSRYLLQQKPVVKTAQNLAEVNGPETLIGPGAKEGTVPTDLDQETGLARLELLGKLEGIDVFDTKPLDSSRKGTMKDPIIIESYDDYRYVGCTGSPAGSHTIMWLKPTVNEVARCWECGSVYKLNPVGVPNDDHHH
SIO_010081: YGL187C
subclass of: SO_0000673
so part of: YGL187C
location: complement(149704..150171)
location: region:149704-150171:-1
so has part: feature:149704-150171:-1:exon

NP_011328.1
type: Protein
SIO_000068: ncbiprotein

S000003155
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:149704-150171:-1:exon

YGL186C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPN1
locus tag: YGL186C
so part of: sequence
location: complement(<151037..>152776)
location: region:151037-152776:-1
so has part: feature:151037-152776:-1:exon
subclass of: SO_0000010

852689
type: Gene
SIO_000068: ncbigene

position:151037:-1
position: 151037
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:152776:-1
position: 152776
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151037-152776:-1:exon

YGL186C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPN1
locus tag: YGL186C
product: Tpn1p
transcript id: NM_001181051.1
SIO_010081: YGL186C
subclass of: SO_0000673
so part of: YGL186C
location: complement(<151037..>152776)
location: region:151037-152776:-1
so has part: feature:151037-152776:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:151037-152776:-1:exon

YGL186C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPN1
locus tag: YGL186C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12649274]
experiment: EXISTENCE:direct assay:GO:0051180 vitamin transport [PMID:12649274]
experiment: EXISTENCE:direct assay:GO:0090482 vitamin transmembrane transporter activity [PMID:12649274]
note: Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
codon start: 1
product: Tpn1p
translation: MNRDNMDTTKRKEDHTKHTTDVIEFYEEGTAASSLNIATEKANSSPSILRRIINRAAWLSKKVDAMGVESTGIQRISPYERGTSKKQFLHVAGLWLSATGGLSSMSSFLLGPLLFGLSFRESVASSLISVTIGCLIAAYCSIMGPQSGCRQMVTARYLFGWWFVKLVALASIIGVMGWSVVNSVVGGEMLAAISNDKVPLWVGIVIVTVCSFLVAIFGIKQVIKVETYLSVPVLTAFLLLYISSSDKYSFVNAYVSKGNLDSSTRKGNWMSFFSLCYSITATWGSITADYYILFPEDTPYIQIFCLTFFGTFLPTCFVGILGLLLASVAMSYKPWSVEYDSHGMGGLLWAGFQRWNGFGKFCVVVLVFSLVSNNIINTYSAAFSIQLSSVFCAKIPRWFWSIVCTIICLVCALIGRNHFSTILGNFLPMIGYWISMYFILLFEENLVFRRFFLHLYTKEFPTVTGEINGPELVGSSKEVEKDAVTNIHLLKRKHKVTKHRYNWDKWEDYEVLTHGYAATFAFIVGVAGVVVGMAQAYWIGPIAAKFGEYGGDVAMWLSMAFSGVVYPPCRYLELRKFGR
SIO_010081: YGL186C
subclass of: SO_0000673
so part of: YGL186C
location: complement(151037..152776)
location: region:151037-152776:-1
so has part: feature:151037-152776:-1:exon

NP_011329.1
type: Protein
SIO_000068: ncbiprotein

S000003154
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:151037-152776:-1:exon

YGL185C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL185C
so part of: sequence
location: complement(<153167..>154306)
location: region:153167-154306:-1
so has part: feature:153167-154306:-1:exon
subclass of: SO_0000010

852690
type: Gene
SIO_000068: ncbigene

position:153167:-1
position: 153167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:154306:-1
position: 154306
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153167-154306:-1:exon

YGL185C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL185C
product: putative hydroxyacid dehydrogenase
transcript id: NM_001181050.1
SIO_010081: YGL185C
subclass of: SO_0000673
so part of: YGL185C
location: complement(<153167..>154306)
location: region:153167-154306:-1
so has part: feature:153167-154306:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153167-154306:-1:exon

YGL185C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL185C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [PMID:17173333]
note: Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
codon start: 1
product: putative hydroxyacid dehydrogenase
translation: MCDSPATTGKPTILFIADPCETSATLNSKAFKEKFRILRYQLDTKEAFLNFLERHEQDKICAIYAGFPAFKKIGGMTRSIIEHKSFPRKNLKCIVLCSRGYDGWDLDTLRKHEIRLYNYQDDENEKLIDDLKLHQVGNDVADCALWHILEGFRKFSYYQKLSRETGNTLTARAKAAEKSGFAFGHELGNMFAESPRGKKCLILGLGSIGKQVAYKLQYGLGMEIHYCKRSEDCTMSQNESWKFHLLDETIYAKLYQFHAIVVTLPGTPQTEHLINRKFLEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLGLDVFNKEPEIDEKIRSSDRLTSITPHLGSATKDVFEQSCELALTRILRVVSGEAASDEHFSRVV
SIO_010081: YGL185C
subclass of: SO_0000673
so part of: YGL185C
location: complement(153167..154306)
location: region:153167-154306:-1
so has part: feature:153167-154306:-1:exon

NP_011330.1
type: Protein
SIO_000068: ncbiprotein

S000003153
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153167-154306:-1:exon

YGL184C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STR3
locus tag: YGL184C
so part of: sequence
location: complement(<154615..>156012)
location: region:154615-156012:-1
so has part: feature:154615-156012:-1:exon
subclass of: SO_0000010

852691
type: Gene
SIO_000068: ncbigene

position:154615:-1
position: 154615
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:156012:-1
position: 156012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:154615-156012:-1:exon

YGL184C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STR3
locus tag: YGL184C
product: cystathionine beta-lyase STR3
transcript id: NM_001181049.3
SIO_010081: YGL184C
subclass of: SO_0000673
so part of: YGL184C
location: complement(<154615..>156012)
location: region:154615-156012:-1
so has part: feature:154615-156012:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:154615-156012:-1:exon

YGL184C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STR3
locus tag: YGL184C
EC number: 4.4.1.13
experiment: EXISTENCE:direct assay:GO:0004121 cystathionine beta-lyase activity [PMID:21478306]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:11565790]
experiment: EXISTENCE:direct assay:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:29436228]
experiment: EXISTENCE:mutant phenotype:GO:0004121 cystathionine beta-lyase activity [PMID:10821189]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:10821189]
experiment: EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:10821189]
note: Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation
codon start: 1
product: cystathionine beta-lyase STR3
translation: MPIKRLDTVVVNTGSQNDQHSASVPPVYLSTTFKVDLNNEDAQNYDYSRSGNPTRSVLQHQIGKLYRVPQENVLAVSSGMTALDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFFKQQSHAVSVHVDTSDFEKFKTVFQSLDKVDCVLLESPTNPLCKVVDIPRILRFVKCISPDTTVVVDNTMMSGLNCNPLQLNPGCDVVYESATKYLNGHHDLMGGVIISKTPEIASKLYFVINSTGAGLSPMDSWLLVRGLKTLGVRLYQQQRNAMILAHWLENSCGFKPTRTNKATKTRFVGLRSNPDFKLHKSFNNGPGAVLSFETGSFEHSKRLVSSKKLSIWAVTVSFGCVNSLLSMPCKMSHASIDPELRKERDFPEDLVRLCCGIENIVDLKKDLLAAMVDADIIEVRENGKYLFNKLNKNLAVNTTIDDLHKPLSIYEEFYNQDLIRKDSELNIKSSKL
SIO_010081: YGL184C
subclass of: SO_0000673
so part of: YGL184C
location: complement(154615..156012)
location: region:154615-156012:-1
so has part: feature:154615-156012:-1:exon

NP_011331.3
type: Protein
SIO_000068: ncbiprotein

S000003152
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:154615-156012:-1:exon

YGL183C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MND1
locus tag: YGL183C
so part of: sequence
location: complement(<156543..>157285)
location: region:156543-157285:-1
so has part: feature:156543-157285:-1:exon
subclass of: SO_0000010

852692
type: Gene
SIO_000068: ncbigene

position:156543:-1
position: 156543
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157285:-1
position: 157285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156543-157285:-1:exon

YGL183C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MND1
locus tag: YGL183C
product: Mnd1p
transcript id: NM_001181048.1
SIO_010081: YGL183C
subclass of: SO_0000673
so part of: YGL183C
location: complement(join(<156543..157199,157283..>157285))
location: region:156543-157285:-1
so has part: feature:157283-157285:-1:exon
so has part: feature:156543-157199:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:157283-157285:-1:exon

position:157283:-1
position: 157283
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:156543-157199:-1:exon

position:157199:-1
position: 157199
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL183C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MND1
locus tag: YGL183C
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11940665]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15249670]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:11470404|PMID:16581767]
note: Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
codon start: 1
product: Mnd1p
translation: MGPKRQTVSLQEKKNRILNFFQETYTFYNIKELEKSIPKKCGISPMIVKDLVQQMIDEDGVISVEKCGNINIYWCFKNQTLQKLYDSSELIKKKIQEVKCDIATYKQELDKTLATGRRKKFTVGQKSYNREALLEKRKKIQDEIKKKSNSLQKIESIRWDAAKIQENKQQIRLKKVHLEKTTDNIEILIDYLYKKFFLKPEQIRKEFGIPEEFKEFTEV
SIO_010081: YGL183C
subclass of: SO_0000673
so part of: YGL183C
location: complement(join(156543..157199,157283..157285))
location: region:156543-157285:-1
so has part: feature:157283-157285:-1:exon
so has part: feature:156543-157199:-1:exon

NP_011332.2
type: Protein
SIO_000068: ncbiprotein

S000003151
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:157283-157285:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:156543-157199:-1:exon

YGL181W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FHT1
alternative label: LSR1
gene: GTS1
locus tag: YGL181W
gene synonym: FHT1; LSR1
so part of: sequence
location: <157906..>159096
location: region:157906-159096:1
so has part: feature:157906-159096:1:exon
subclass of: SO_0000010

852694
type: Gene
SIO_000068: ncbigene

position:157906:1
position: 157906
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159096:1
position: 159096
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:157906-159096:1:exon

YGL181W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FHT1
alternative label: LSR1
gene: GTS1
locus tag: YGL181W
gene synonym: FHT1; LSR1
product: Gts1p
transcript id: NM_001181046.1
SIO_010081: YGL181W
subclass of: SO_0000673
so part of: YGL181W
location: <157906..>159096
location: region:157906-159096:1
so has part: feature:157906-159096:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:157906-159096:1:exon

YGL181W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FHT1
alternative label: LSR1
gene: GTS1
locus tag: YGL181W
gene synonym: FHT1; LSR1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11549884|PMID:17449140]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:17449140]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:18208507]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:17449140]
experiment: EXISTENCE:mutant phenotype:GO:0010512 negative regulation of phosphatidylinositol biosynthetic process [PMID:18208507]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12782635]
experiment: EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16911513]
experiment: EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:16911513]
note: Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
codon start: 1
product: Gts1p
translation: MRFRSSSHSLKHVDRELKELINSSENANKCGECGNFYPTWCSVNLGVFLCGRCASVHRKVFGSRDDDAFSNVKSLSMDRWTREDIDELVSLGGNKGNARFWNPKNVPFPFDGDDDKAIVEHYIRDKYILGKFRYDEIKPEDFGSRMDDFDGESDRFDERNRSRSRSRSHSFYKGGHNRSDYGGSRDSFQSSGSRYSRQLAELKDMGFGDTNKNLDALSSAHGNINRAIDYLEKSSSSRNSVSAAATTSTPPLPRRRATTSGPQPAIFDGTNVITPDFTSNSASFVQAKPAVFDGTLQQYYDPATGMIYVDQQQYAMAMQQQQQQQQQLAVAQAQAQAQAQAQAQVQAQAQAQAQAQAQAQQIQMQQLQMQQQQQAPLSFQQMSQGGNLPQGYFYTQ
SIO_010081: YGL181W
subclass of: SO_0000673
so part of: YGL181W
location: 157906..159096
location: region:157906-159096:1
so has part: feature:157906-159096:1:exon

NP_011334.1
type: Protein
SIO_000068: ncbiprotein

S000003149
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:157906-159096:1:exon

YGL180W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APG1
alternative label: AUT3
alternative label: CVT10
gene: ATG1
locus tag: YGL180W
gene synonym: APG1; AUT3; CVT10
so part of: sequence
location: <160065..>162758
location: region:160065-162758:1
so has part: feature:160065-162758:1:exon
subclass of: SO_0000010

852695
type: Gene
SIO_000068: ncbigene

position:160065:1
position: 160065
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:162758:1
position: 162758
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160065-162758:1:exon

YGL180W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APG1
alternative label: AUT3
alternative label: CVT10
gene: ATG1
locus tag: YGL180W
gene synonym: APG1; AUT3; CVT10
product: serine/threonine protein kinase ATG1
transcript id: NM_001181045.1
SIO_010081: YGL180W
subclass of: SO_0000673
so part of: YGL180W
location: <160065..>162758
location: region:160065-162758:1
so has part: feature:160065-162758:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160065-162758:1:exon

YGL180W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APG1
alternative label: AUT3
alternative label: CVT10
gene: ATG1
locus tag: YGL180W
gene synonym: APG1; AUT3; CVT10
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]
experiment: EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:11689437|PMID:15659643|PMID:18497569]
experiment: EXISTENCE:direct assay:GO:0000421 autophagosome membrane [PMID:22885598]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22885598|PMID:25921291|PMID:9224897|PMID:33536246]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9190802|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]
experiment: EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]
experiment: EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]
experiment: EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:22778255|PMID:9224897]
experiment: EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:9224897]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]
experiment: EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210]
experiment: EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10995454|PMID:12589048]
experiment: EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:33536246]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0044805 late nucleophagy [PMID:22768199]
experiment: EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]
experiment: EXISTENCE:physical interaction:GO:1990316 Atg1/ULK1 kinase complex [PMID:15743910]
note: Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; forms a complex with Atg13p and Atg17p during autophagy; required for re-phosphorylation of Atg13p during termination of autophagy, following prolonged nitrogen starvation; essential for cell cycle progression from G2/M to G1 under nitrogen starvation
codon start: 1
product: serine/threonine protein kinase ATG1
translation: MGDIKNKDHTTSVNHNLMASAGNYTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSYELEDDLPELESKSKGIVESNMFVSEYLSKQPKSPNSNLAGHQSMADNPAELSDALKNSNILTAPAVKTDHTQAVDKKASNNKYHNSLVSDRSFEREYVVVEKKSVEVNSLADEVAQAGFNPNPIKHPTSTQNQNVLLNEQFSPNNQQYFQNQGENPRLLRATSSSSGGSDGSRRPSLVDRRLSISSLNPSNALSRALGIASTRLFGGANQQQQQQQITSSPPYSQTLLNSQLFHELTENIILRIDHLQHPETLKLDNTNIVSILESLAAKAFVVYSYAEVKFSQIVPLSTTLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYKEDCLSTKTFGKGRTLSATSQLSATFNKLPRSEMILLCNEAIVLYMKALSILSKSMQVTSNWWYESQEKSCSLRVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGSSEEPVYLEKLLYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDDFTNAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYIDSIANRLKILRQKMNHQN
SIO_010081: YGL180W
subclass of: SO_0000673
so part of: YGL180W
location: 160065..162758
location: region:160065-162758:1
so has part: feature:160065-162758:1:exon

NP_011335.1
type: Protein
SIO_000068: ncbiprotein

S000003148
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160065-162758:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS707; Autonomously Replicating Sequence
so part of: sequence
location: 163218..163318
location: region:163218-163318:1
so has part: feature:163218-163318:1:region

S000118453
type: SGD
SIO_000068: sgd

position:163218:1
position: 163218
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:163318:1
position: 163318
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:163218-163318:1:region

YGL179C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOS3
locus tag: YGL179C
so part of: sequence
location: complement(<163409..>165091)
location: region:163409-165091:-1
so has part: feature:163409-165091:-1:exon
subclass of: SO_0000010

852696
type: Gene
SIO_000068: ncbigene

position:163409:-1
position: 163409
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:165091:-1
position: 165091
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:163409-165091:-1:exon

YGL179C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOS3
locus tag: YGL179C
product: serine/threonine protein kinase TOS3
transcript id: NM_001181044.3
SIO_010081: YGL179C
subclass of: SO_0000673
so part of: YGL179C
location: complement(<163409..>165091)
location: region:163409-165091:-1
so has part: feature:163409-165091:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:163409-165091:-1:exon

YGL179C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOS3
locus tag: YGL179C
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:12847291|PMID:16201971]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15879520|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:mutant phenotype:GO:1900180 regulation of protein localization to nucleus [PMID:15340085]
note: Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; localizes to cytosol and peroxisomes; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase TOS3
translation: MVLLKEPVQPLPRSSLLYNNASNSSSRIKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFMCHYGKSDAASVLTNLETFHELKVSPPSSCKRVELVSLPVNSSFASLDSVYMENFDHNNLRTGADRNSTYSPSIYDANTLSPSAYHNIGSRESSYSSFSSFTSSTAFASQISIQDAPAIGDQQCLIGESGSSLRVNSCEFPQYTTMSPVGEYPFESTEASLSSTLTPVGNVPQRIKAHLVEGKSNSKDDLRIEADASLVFEASDAQRTRRRMSLYKL
SIO_010081: YGL179C
subclass of: SO_0000673
so part of: YGL179C
location: complement(163409..165091)
location: region:163409-165091:-1
so has part: feature:163409-165091:-1:exon

NP_011336.3
type: Protein
SIO_000068: ncbiprotein

S000003147
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:163409-165091:-1:exon

YGL178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HTR1
alternative label: PUF5
alternative label: UTH4
gene: MPT5
locus tag: YGL178W
gene synonym: HTR1; PUF5; UTH4
so part of: sequence
location: <167352..>170571
location: region:167352-170571:1
so has part: feature:167352-170571:1:exon
subclass of: SO_0000010

852697
type: Gene
SIO_000068: ncbigene

position:167352:1
position: 167352
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:170571:1
position: 170571
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167352-170571:1:exon

YGL178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HTR1
alternative label: PUF5
alternative label: UTH4
gene: MPT5
locus tag: YGL178W
gene synonym: HTR1; PUF5; UTH4
product: Mpt5p
transcript id: NM_001181043.1
SIO_010081: YGL178W
subclass of: SO_0000673
so part of: YGL178W
location: join(<167352..167354,167995..>170571)
location: region:167352-170571:1
so has part: feature:167352-167354:1:exon
so has part: feature:167995-170571:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167352-167354:1:exon

position:167354:1
position: 167354
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:167995-170571:1:exon

position:167995:1
position: 167995
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HTR1
alternative label: PUF5
alternative label: UTH4
gene: MPT5
locus tag: YGL178W
gene synonym: HTR1; PUF5; UTH4
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11157761|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20498834|PMID:22842922|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:20427513]
experiment: EXISTENCE:direct assay:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16715093]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:29297464]
experiment: EXISTENCE:mutant phenotype:GO:1902416 positive regulation of mRNA binding [PMID:22890846]
experiment: EXISTENCE:mutant phenotype:GO:1903450 regulation of G1 to G0 transition [PMID:31141453]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:16715093|PMID:20705650]
experiment: EXISTENCE:physical interaction:GO:0045947 negative regulation of translational initiation [PMID:20705650]
note: mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
codon start: 1
product: Mpt5p
translation: MINNEPFPSADSASILTTSTSNNSLMSYNHQPQLSINSVQSLLEPVTPPPLGQMNNKRNHQKAHSLDLSGFNQFISSTQSPLALMNNTSTSNSANSFSPNPNAASNSTGLSASMANPPAILPLINEFDLEMDGPRRKSSHDFTVVAPSNSGVNTSSLIMETPSSSVTPAASLRNFSNSNNAASKCGVDNSSFGLSSSTSSSMVEISALPLRDLDYIKLATDQFGCRFLQKKLETPSESNMVRDLMYEQIKPFFLDLILDPFGNYLVQKLCDYLTAEQKTLLIQTIYPNVFQISINQYGTRSLQKIIDTVDNEVQIDLIIKGFSQEFTSIEQVVTLINDLNGNHVIQKCIFKFSPSKFGFIIDAIVEQNNIITISTHKHGCCVLQKLLSVCTLQQIFKISVKIVQFLPGLINDQFGNYIIQFLLDIKELDFYLLAELFNRLSNELCQLSCLKFSSNVVEKFIKKLFRIITGFIVNNNGGASQRTAVASDDVINASMNILLTTIDIFTVNLNVLIRDNFGNYALQTLLDVKNYSPLLAYNKNSNAIGQNSSSTLNYGNFCNDFSLKIGNLIVLTKELLPSIKTTSYAKKIKLKVKAYAEATGIPFTDISPQVTAMSHNNLQTINNENKNPHNKNSHNHNHNHNHNHAHNNNNNNNQKSHTRHFSLPANAYHRRSNSSVTNNFSNQYAQDQKIHSPQQIMNFNQNAYPSMGAPSFNSQTNPPLVSHNSLQNFDNRQFANLMAHPNSAAPIHSFSSSNITNVNPNVSRGFKQPGFMMNETDKINANHFSPYSNANSQNFNESFVPRMQYQTEGANWDSSLSMKSQHIGQGPYNQVNMSRNASISNMPAMNTARTSDELQFTLP
SIO_010081: YGL178W
subclass of: SO_0000673
so part of: YGL178W
location: join(167352..167354,167995..170571)
location: region:167352-170571:1
so has part: feature:167352-167354:1:exon
so has part: feature:167995-170571:1:exon

NP_011337.1
type: Protein
SIO_000068: ncbiprotein

S000003146
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167352-167354:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:167995-170571:1:exon

YGL176C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL176C
so part of: sequence
location: complement(<171415..>173079)
location: region:171415-173079:-1
so has part: feature:171415-173079:-1:exon
subclass of: SO_0000010

852699
type: Gene
SIO_000068: ncbigene

position:171415:-1
position: 171415
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:173079:-1
position: 173079
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:171415-173079:-1:exon

YGL176C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL176C
product: uncharacterized protein
transcript id: NM_001181041.1
SIO_010081: YGL176C
subclass of: SO_0000673
so part of: YGL176C
location: complement(<171415..>173079)
location: region:171415-173079:-1
so has part: feature:171415-173079:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:171415-173079:-1:exon

YGL176C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL176C
note: hypothetical protein; contributes to high inhibitor stress tolerance; deletion mutant is viable
codon start: 1
product: uncharacterized protein
translation: MTPNLPGFYYDRERRRYFRISENQSISTTGTTNQYRKDNIKRQCVEENYDKKFSMIKKKRQQTLQKYKLSLLNPLERAFRPLSYEKYMIGLNMQYASHSLTEGHHSHSSANVKSLNFPHRIQIGVLANCILLVTQEGCFHSKLVFATNKGYVAGFSSLDNFSEENFFTGFSMAELNPMLKYKSEPTDVFKTMKLERTVAIKEGPSHYFYHNVNTRSNVHTFAIFLQDFSSLKLLKIRQVKLKENCQVHDSLVVGDTLIITVNYRCHFYDLIPETFPNPYIFSPAKSSRKHKSRSDITSLSFCLQEDALSPLKKTNTGVFYLGYRNGDSMAIVFTNITNMTLQYSKTNGMTSESRNQPIRNSLKSVVSIKALNNKGLILISGMADKENVQQLVIADTFLEDILTEIPVVSFKTKFLNVTKDTEILEISDDGRYFIYGSTSARDGKGDFEVFCTTLSGNLDYEKSEGGNITLYPIGGMKNYCRLENFQFESIHLHSAFIPPRYVNPFDAVEPLGEESSTSPYDIPEEALSQKICILIRREDDPYNGANIFITSALT
SIO_010081: YGL176C
subclass of: SO_0000673
so part of: YGL176C
location: complement(171415..173079)
location: region:171415-173079:-1
so has part: feature:171415-173079:-1:exon

NP_011339.1
type: Protein
SIO_000068: ncbiprotein

S000003144
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:171415-173079:-1:exon

YGL175C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COM1
gene: SAE2
locus tag: YGL175C
gene synonym: COM1
so part of: sequence
location: complement(<173285..>174322)
location: region:173285-174322:-1
so has part: feature:173285-174322:-1:exon
subclass of: SO_0000010

852700
type: Gene
SIO_000068: ncbigene

position:173285:-1
position: 173285
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:174322:-1
position: 174322
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:173285-174322:-1:exon

YGL175C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COM1
gene: SAE2
locus tag: YGL175C
gene synonym: COM1
product: ssDNA endodeoxyribonuclease SAE2
transcript id: NM_001181040.1
SIO_010081: YGL175C
subclass of: SO_0000673
so part of: YGL175C
location: complement(<173285..>174322)
location: region:173285-174322:-1
so has part: feature:173285-174322:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:173285-174322:-1:exon

YGL175C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COM1
gene: SAE2
locus tag: YGL175C
gene synonym: COM1
experiment: EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:18042458]
experiment: EXISTENCE:direct assay:GO:0000737 DNA catabolic process, endonucleolytic [PMID:18042458]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:18042458]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030870 Mre11 complex [PMID:25231868]
experiment: EXISTENCE:direct assay:GO:1905779 positive regulation of exonuclease activity [PMID:25231868]
experiment: EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]
experiment: EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:18806779]
experiment: EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:22745819]
experiment: EXISTENCE:mutant phenotype:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:18042458]
experiment: EXISTENCE:mutant phenotype:GO:0000706 meiotic DNA double-strand break processing [PMID:9215888]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:19595717]
experiment: EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:26490958]
experiment: EXISTENCE:mutant phenotype:GO:0000737 DNA catabolic process, endonucleolytic [PMID:18042458]
experiment: EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:18042458]
experiment: EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:18806779]
experiment: EXISTENCE:mutant phenotype:GO:0010791 DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [PMID:23254329]
experiment: EXISTENCE:mutant phenotype:GO:0031860 telomeric 3' overhang formation [PMID:19595717]
experiment: EXISTENCE:mutant phenotype:GO:0035306 positive regulation of dephosphorylation [PMID:25831494]
note: Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8
codon start: 1
product: ssDNA endodeoxyribonuclease SAE2
translation: MVTGEENVYLKSSLSILKELSLDELLNVQYDVTTLIAKRVQALQNRNKCVLEEPNSKLAEILCHEKNAPQQSSQTSAGPGEQDSEDFILTQFDEDIKKESAEVHYRNENKHTVQLPLVTMPPNRHKRKISEFSSPLNGLNNLSDLEDCSDTVIHEKDNDKENKTRKLLGIELENPESTSPNLYKNVKDNFLFDFNTNPLTKRAWILEDFRPNEDIAPVKRGRRKLERFYAQVGKPEDSKHRSLSVVIESQNSDYEFAFDNLRNRSKSPPGFGRLDFPSTQEGNEDKKKSQEIIRRKTKYRFLMASNNKIPPYEREYVFKREQLNQIVDDGCFFWSDKLLQIYARC
SIO_010081: YGL175C
subclass of: SO_0000673
so part of: YGL175C
location: complement(173285..174322)
location: region:173285-174322:-1
so has part: feature:173285-174322:-1:exon

NP_011340.1
type: Protein
SIO_000068: ncbiprotein

S000003143
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:173285-174322:-1:exon

YGL174W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CWC26
gene: BUD13
locus tag: YGL174W
gene synonym: CWC26
so part of: sequence
location: <174545..>175345
location: region:174545-175345:1
so has part: feature:174545-175345:1:exon
subclass of: SO_0000010

852701
type: Gene
SIO_000068: ncbigene

position:174545:1
position: 174545
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:175345:1
position: 175345
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:174545-175345:1:exon

YGL174W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CWC26
gene: BUD13
locus tag: YGL174W
gene synonym: CWC26
product: Bud13p
transcript id: NM_001181039.3
SIO_010081: YGL174W
subclass of: SO_0000673
so part of: YGL174W
location: <174545..>175345
location: region:174545-175345:1
so has part: feature:174545-175345:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:174545-175345:1:exon

YGL174W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CWC26
gene: BUD13
locus tag: YGL174W
gene synonym: CWC26
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:15565172]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11452010]
experiment: EXISTENCE:direct assay:GO:0070274 RES complex [PMID:15565172]
note: Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids
codon start: 1
product: Bud13p
translation: MALHQYLSETYGPTKPKNKTKKKKKESKSDANSDKTSLIVKERLSTLQQEQEKSGVASFSKFDKQKSKNIWKNLETNELSHAITHPSASSITGNESKNDLKEIRAQEPLVTVADKSKTRKTIYRDAQGHKIQEDSKIDDSSFSRSKYEDEKAAEREQYLKNLNMGDVQKLGINVDAHDKKKNQTASSLTIEDPAITFTHDKERTVKTSLLGRKLYDKPAPENRFAIMPGSRWDGVHRSNGFEEKWFAKQNEINEKKVQSYTLQEDY
SIO_010081: YGL174W
subclass of: SO_0000673
so part of: YGL174W
location: 174545..175345
location: region:174545-175345:1
so has part: feature:174545-175345:1:exon

NP_011341.3
type: Protein
SIO_000068: ncbiprotein

S000003142
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:174545-175345:1:exon

YGL173C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DST2
alternative label: KEM1
alternative label: RAR5
alternative label: SEP1
alternative label: SKI1
gene: XRN1
locus tag: YGL173C
gene synonym: DST2; KEM1; RAR5; SEP1; SKI1
so part of: sequence
location: complement(<175527..>180113)
location: region:175527-180113:-1
so has part: feature:175527-180113:-1:exon
subclass of: SO_0000010

852702
type: Gene
SIO_000068: ncbigene

position:175527:-1
position: 175527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:180113:-1
position: 180113
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175527-180113:-1:exon

YGL173C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DST2
alternative label: KEM1
alternative label: RAR5
alternative label: SEP1
alternative label: SKI1
gene: XRN1
locus tag: YGL173C
gene synonym: DST2; KEM1; RAR5; SEP1; SKI1
product: chromatin-binding exonuclease XRN1
transcript id: NM_001181038.1
SIO_010081: YGL173C
subclass of: SO_0000673
so part of: YGL173C
location: complement(<175527..>180113)
location: region:175527-180113:-1
so has part: feature:175527-180113:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175527-180113:-1:exon

YGL173C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DST2
alternative label: KEM1
alternative label: RAR5
alternative label: SEP1
alternative label: SKI1
gene: XRN1
locus tag: YGL173C
gene synonym: DST2; KEM1; RAR5; SEP1; SKI1
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:12730603|PMID:25811606]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004534 5'-3' exoribonuclease activity [PMID:3545079]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0016078 tRNA catabolic process [PMID:21632824]
experiment: EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:30899024]
experiment: EXISTENCE:direct assay:GO:0090512 eisosome membrane domain/MCC [PMID:25811606]
experiment: EXISTENCE:direct assay:GO:0110155 NAD-cap decapping [PMID:35173156]
experiment: EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:9488433]
experiment: EXISTENCE:genetic interaction:GO:0043144 sno(s)RNA processing [PMID:9488433]
experiment: EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:10848586]
experiment: EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]
experiment: EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:24119399]
experiment: EXISTENCE:mutant phenotype:GO:0004534 5'-3' exoribonuclease activity [PMID:1979303]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9488433]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:30899024]
experiment: EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:16240118]
experiment: EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:29465287]
experiment: EXISTENCE:mutant phenotype:GO:0032204 regulation of telomere maintenance [PMID:28160602]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:23706738]
experiment: EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:23706738|PMID:33258404]
experiment: EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:24567736]
experiment: EXISTENCE:mutant phenotype:GO:0070479 nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay [PMID:30874502]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]
experiment: EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31913314]
experiment: EXISTENCE:mutant phenotype:GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [PMID:33258404]
note: Evolutionarily-conserved 5'-3' exonuclease; deNADding enzyme that modulates mitochondrial NAD-capped RNA; component of cytoplasmic P- bodies involved in mRNA decay; enters nucleus, positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and turnover of tRNA introns; negative regulator of autophagy; activated by scavenger decapping enzyme Dcs1p
codon start: 1
product: chromatin-binding exonuclease XRN1
translation: MGIPKFFRYISERWPMILQLIEGTQIPEFDNLYLDMNSILHNCTHGNDDDVTKRLTEEEVFAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALKKAIENGDEIPKGEPFDSNSITPGTEFMAKLTKNLQYFIHDKISNDSKWREVQIIFSGHEVPGEGEHKIMNFIRHLKSQKDFNQNTRHCIYGLDADLIMLGLSTHGPHFALLREEVTFGRRNSEKKSLEHQNFYLLHLSLLREYMELEFKEIADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLHLNKGAFPVLLQTFKEALLHTDGYINEHGKINLKRLGVWLNYLSQFELLNFEKDDIDVEWFNKQLENISLEGERKRQRVGKKLLVKQQKKLIGSIKPWLMEQLQEKLSPDLPDEEIPTLELPKDLDMKDHLEFLKEFAFDLGLFITHSKSKGSYSLKMDLDSINPDETEEEFQNRVNSIRKTIKKYQNAIIVEDKEELETEKTIYNERFERWKHEYYHDKLKFTTDSEEKVRDLAKDYVEGLQWVLYYYYRGCPSWSWYYPHHYAPRISDLAKGLDQDIEFDLSKPFTPFQQLMAVLPERSKNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADWEAVVLISFVDEKRLIEAMQPYLRKLSPEEKTRNQFGKDLIYSFNPQVDNLYKSPLGGIFSDIEHNHCVEKEYITIPLDSSEIRYGLLPNAKLGAEMLAGFPTLLSLPFTSSLEYNETMVFQQPSKQQSMVLQITDIYKTNNVTLEDFSKRHLNKVIYTRWPYLRESKLVSLTDGKTIYEYQESNDKKKFGFITKPAETQDKKLFNSLKNSMLRMYAKQKAVKIGPMEAIATVFPVTGLVRDSDGGYIKTFSPTPDYYPLQLVVESVVNEDERYKERGPIPIEEEFPLNSKVIFLGDYAYGGETTIDGYSSDRRLKITVEKKFLDSEPTIGKERLQMDHQAVKYYPSYIVSKNMHLHPLFLSKITSKFMITDATGKHINVGIPVKFEARHQKVLGYARRNPRGWEYSNLTLNLLKEYRQTFPDFFFRLSKVGNDIPVLEDLFPDTSTKDAMNLLDGIKQWLKYVSSKFIAVSLESDSLTKTSIAAVEDHIMKYAANIEGHERKQLAKVPREAVLNPRSSFALLRSQKFDLGDRVVYIQDSGKVPIFSKGTVVGYTTLSSSLSIQVLFDHEIVAGNNFGGRLRTNRGLGLDASFLLNITNRQFIYHSKASKKALEKKKQSNNRNNNTKTAHKTPSKQQSEEKLRKERAHDLLNFIKKDTNEKNSESVDNKSMGSQKDSKPAKKVLLKRPAQKSSENVQVDLANFEKAPLDNPTVAGSIFNAVANQYSDGIGSNLNIPTPPHPMNVVGGPIPGANDVADVGLPYNIPPGFMTHPNGLHPLHPHQMPYPNMNGMSIPPPAPHGFGQPISFPPPPPMTNVSDQGSRIVVNEKESQDLKKFINGKQHSNGSTIGGETKNSRKGEIKPSSGTNSTECQSPKSQSNAADRDNKKDEST
SIO_010081: YGL173C
subclass of: SO_0000673
so part of: YGL173C
location: complement(175527..180113)
location: region:175527-180113:-1
so has part: feature:175527-180113:-1:exon

NP_011342.1
type: Protein
SIO_000068: ncbiprotein

S000003141
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175527-180113:-1:exon

YGL172W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSP49
gene: NUP49
locus tag: YGL172W
gene synonym: NSP49
so part of: sequence
location: <180700..>182118
location: region:180700-182118:1
so has part: feature:180700-182118:1:exon
subclass of: SO_0000010

852703
type: Gene
SIO_000068: ncbigene

position:180700:1
position: 180700
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:182118:1
position: 182118
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:180700-182118:1:exon

YGL172W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSP49
gene: NUP49
locus tag: YGL172W
gene synonym: NSP49
product: FG-nucleoporin NUP49
transcript id: NM_001181037.1
SIO_010081: YGL172W
subclass of: SO_0000673
so part of: YGL172W
location: <180700..>182118
location: region:180700-182118:1
so has part: feature:180700-182118:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:180700-182118:1:exon

YGL172W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSP49
gene: NUP49
locus tag: YGL172W
gene synonym: NSP49
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:1385442]
experiment: EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19680227]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406|PMID:24574455|PMID:9813081]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906|PMID:9971735]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7813444]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7813444]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
note: FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
codon start: 1
product: FG-nucleoporin NUP49
translation: MFGLNKASSTPAGGLFGQASGASTGNANTGFSFGGTQTGQNTGPSTGGLFGAKPAGSTGGLGASFGQQQQQSQTNAFGGSATTGGGLFGNKPNNTANTGGGLFGANSNSNSGSLFGSNNAQTSRGLFGNNNTNNINNSSSGMNNASAGLFGSKPAGGTSLFGNTSTSSAPAQNQGMFGAKPAGTSLFGNNAGNTTTGGGLFGSKPTGATSLFGSSNNNNNNNNSNNIMSASGGLFGNQQQQLQQQPQMQCALQNLSQLPITPMTRISELPPQIRQEIEQLDQYIQKQVQISHHLKADTIDHDELIDSIPRDVAYLLKSESATSQYLKQDLKKISSFKSLIDEDLLDTQTFSVLLQQLLTPGSKISSNDLDKFFQKKIHLYEKKLEDYCRILSDIETAVNGIDTDLFGAPNNPNSTAITADLGSSEAENLLQLKTGLAAIVSTVIEEFTLFMDIAERIAVLHQKTKTLASLSI
SIO_010081: YGL172W
subclass of: SO_0000673
so part of: YGL172W
location: 180700..182118
location: region:180700-182118:1
so has part: feature:180700-182118:1:exon

NP_011343.1
type: Protein
SIO_000068: ncbiprotein

S000003140
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:180700-182118:1:exon

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of two upstream open reading frames (uORFs) in 5' untranslated region of ROK1 gene, regulate translation
so part of: sequence
location: 182286..182407
location: region:182286-182407:1
so has part: feature:182286-182407:1:region

position:182286:1
position: 182286
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:182407:1
position: 182407
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182286-182407:1:region

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of two upstream open reading frames (uORFs) in 5' untranslated region of ROK1 gene, regulate translation
so part of: sequence
location: 182291..182329
location: region:182291-182329:1
so has part: feature:182291-182329:1:region

position:182291:1
position: 182291
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:182329:1
position: 182329
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182291-182329:1:region

YGL171W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ROK1
locus tag: YGL171W
so part of: sequence
location: <182390..>184084
location: region:182390-184084:1
so has part: feature:182390-184084:1:exon
subclass of: SO_0000010

852704
type: Gene
SIO_000068: ncbigene

position:182390:1
position: 182390
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184084:1
position: 184084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182390-184084:1:exon

YGL171W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ROK1
locus tag: YGL171W
product: RNA-dependent ATPase ROK1
transcript id: NM_001181036.1
SIO_010081: YGL171W
subclass of: SO_0000673
so part of: YGL171W
location: <182390..>184084
location: region:182390-184084:1
so has part: feature:182390-184084:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:182390-184084:1:exon

YGL171W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ROK1
locus tag: YGL171W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9154839]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]
experiment: EXISTENCE:direct assay:GO:0030490 maturation of SSU-rRNA [PMID:23630256]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]
experiment: EXISTENCE:mutant phenotype:GO:0048254 snoRNA localization [PMID:18833290]
note: RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
codon start: 1
product: RNA-dependent ATPase ROK1
translation: MDIFRVLTRGASVKKESGPKAKAADYSVINGNDENHKEDNNESQIVKELDFFRNKRIISKVEDDREKTTENDSPNKEEKSGNDDGLIKPVITNTVEASALRKSYKGNVSGIDIPLPIGSFEDLISRFSFDKRLLNNLIENGFTEPTPIQCECIPVALNNRDVLACGPTGSGKTLAFLIPLVQQIIDDKQTAGLKGLIISPTKELANQIFIECFKLSYKIFLEKKRPLQVALLSKSLGAKLKNKVVSDKKYDIIISTPLRLIDVVKNEALDLSKVKHLIFDEADKLFDKTFVEQSDDILSACREPSLRKAMFSATIPSNVEEIAQSIMMDPVRVIIGHKEAANTNIEQKLIFCGNEEGKLIAIRQLVQEGEFKPPIIIFLESITRAKALYHELMYDRINVDVIHAERTALQRDRIIERFKTGELWCLICTDVLARGIDFKGVNLVINYDVPGSSQAYVHRIGRTGRGGRSGKAITFYTKQDSVAIKPIINVMKQSGCEVSEWMDKMAKMTRKEKESIKNGKAHKERKQITTVPKMDKAKRRRQQEMIAASKRRKNEELSKKHFSK
SIO_010081: YGL171W
subclass of: SO_0000673
so part of: YGL171W
location: 182390..184084
location: region:182390-184084:1
so has part: feature:182390-184084:1:exon

NP_011344.1
type: Protein
SIO_000068: ncbiprotein

S000003139
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:182390-184084:1:exon

YGL170C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO74
locus tag: YGL170C
so part of: sequence
location: complement(<184153..>185394)
location: region:184153-185394:-1
so has part: feature:184153-185394:-1:exon
subclass of: SO_0000010

852705
type: Gene
SIO_000068: ncbigene

position:184153:-1
position: 184153
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:185394:-1
position: 185394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184153-185394:-1:exon

YGL170C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO74
locus tag: YGL170C
product: Spo74p
transcript id: NM_001181035.3
SIO_010081: YGL170C
subclass of: SO_0000673
so part of: YGL170C
location: complement(<184153..>185394)
location: region:184153-185394:-1
so has part: feature:184153-185394:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184153-185394:-1:exon

YGL170C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO74
locus tag: YGL170C
experiment: EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:12796288]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0035974 meiotic spindle pole body [PMID:12796288]
note: Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
codon start: 1
product: Spo74p
translation: MGAGTLLNGLEKENFPNNIHSDLPAYPNMDSQEDGNTSKESKRNSPVKQKSQKDEEKSSKMGTASNIFHENKDIHERSEHTDDFNDGLKLAPDSSPSLKECQFKNWESFWCNTEGYKTKHMQPFHFTSGLEEIKEPVMELNISTSPYKGQRPNSAPTEYSAATTAFTKTQLEVSFLKTNLLTYIKKEIDICLSSVPFFDDAVQMQKKFLEYRDIDLDEEYELKILGELLNDLNFFHMQENSLLNRELAVRRFSNQPESQNLPSIRDFRNPLLPIDNRPSPPLGLKRNGKSFEETYDFTSNTSNFWGEKAELQNSITGGTPYFFHPNNIHQTKPFMSFENQNELLFQRKNSDYKQHFNSGRNIHNGVESKSYRGVGLNDSYQKGYAAMTKSFGNIDLNRMPRRSNEEMYSWSRN
SIO_010081: YGL170C
subclass of: SO_0000673
so part of: YGL170C
location: complement(184153..185394)
location: region:184153-185394:-1
so has part: feature:184153-185394:-1:exon

NP_011345.3
type: Protein
SIO_000068: ncbiprotein

S000003138
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184153-185394:-1:exon

YNCG0007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0007C
so part of: sequence
location: complement(185714..185786)
location: region:185714-185786:-1
so has part: feature:185714-185786:-1:exon
subclass of: SO_0000663

852706
type: Gene
SIO_000068: ncbigene

position:185714:-1
position: 185714
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:185786:-1
position: 185786
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:185714-185786:-1:exon

YNCG0007C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0007C
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCG0007C
subclass of: SO_0000673
so part of: YNCG0007C
location: complement(185714..185786)
location: region:185714-185786:-1
so has part: feature:185714-185786:-1:exon

S000006622
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:185714-185786:-1:exon

YGL169W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUA5
locus tag: YGL169W
so part of: sequence
location: <186059..>187339
location: region:186059-187339:1
so has part: feature:186059-187339:1:exon
subclass of: SO_0000010

852707
type: Gene
SIO_000068: ncbigene

position:186059:1
position: 186059
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187339:1
position: 187339
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:186059-187339:1:exon

YGL169W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SUA5
locus tag: YGL169W
product: threonylcarbamoyladenylate synthase
transcript id: NM_001181034.1
SIO_010081: YGL169W
subclass of: SO_0000673
so part of: YGL169W
location: <186059..>187339
location: region:186059-187339:1
so has part: feature:186059-187339:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:186059-187339:1:exon

YGL169W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SUA5
locus tag: YGL169W
EC number: 2.7.7.87
experiment: EXISTENCE:direct assay:GO:0002949 tRNA threonylcarbamoyladenosine modification [PMID:23620299]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25038083]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:19369944]
experiment: EXISTENCE:direct assay:GO:0061710 L-threonylcarbamoyladenylate synthase [PMID:23620299]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:19369944]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:19884342]
experiment: EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:19287007|PMID:21183954]
note: Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length
codon start: 1
product: threonylcarbamoyladenylate synthase
translation: MYLGRHFLAMTSKALFDTKILKVNPLSIIFSPDAHIDGSLPTITDPETEAALVEAARIIRDTDETVAFPTETVYGLGGSALNDNSVLSIYRAKNRPSDNPLITHVSSIDQLNRKVFNQPHLSGTSLFDNIPSIYRPLISSLWPGPLTILLPVPSSEHSALSKLTTADQPTFAVRIPANPVARALIALSDTPIAAPSANASTRPSPTLASHVYHDLKDKIPIILDGGACKVGVESTVVDGLCNPPTLLRPGGFTYEEIVKLGGEAWSLCKVENKKTVEKGEKVRTPGMKYRHYSPSAKVVLLVPHCEGDGILKGVDRMERLKRLIETELKANSNIKKIAILTSLKLRDSDLQSKIFNEPDFSSKTFIIERLGQSGEEIQTNLFAALRKVDENDKVDLIFVEGINEEGEGLAVMNRLRKAAANNCIQF
SIO_010081: YGL169W
subclass of: SO_0000673
so part of: YGL169W
location: 186059..187339
location: region:186059-187339:1
so has part: feature:186059-187339:1:exon

NP_011346.1
type: Protein
SIO_000068: ncbiprotein

S000003137
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:186059-187339:1:exon

YGL168W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HUR1
locus tag: YGL168W
so part of: sequence
location: <187464..>187796
location: region:187464-187796:1
so has part: feature:187464-187796:1:exon
subclass of: SO_0000010

852708
type: Gene
SIO_000068: ncbigene

position:187464:1
position: 187464
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:187796:1
position: 187796
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187464-187796:1:exon

YGL168W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HUR1
locus tag: YGL168W
product: Hur1p
transcript id: NM_001181033.1
SIO_010081: YGL168W
subclass of: SO_0000673
so part of: YGL168W
location: <187464..>187796
location: region:187464-187796:1
so has part: feature:187464-187796:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187464-187796:1:exon

YGL168W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HUR1
locus tag: YGL168W
experiment: EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:12615994]
experiment: EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:28987344]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0035825 homologous recombination [PMID:28987344]
note: Protein with a role in DNA repair; mutants show reduced efficiency of non-homologous end-joining repair
codon start: 1
product: Hur1p
translation: MFILVSVVNICTYIHLHMFPLISTFTSIGLGVLMKDKGKEGKTIKAQNVTYQTFEKYVESSSFFFLVHNFLNSSTMKTLLLMSNNNSISEIPSFSVLKILWKNGIYIAHI
SIO_010081: YGL168W
subclass of: SO_0000673
so part of: YGL168W
location: 187464..187796
location: region:187464-187796:1
so has part: feature:187464-187796:1:exon

NP_011347.1
type: Protein
SIO_000068: ncbiprotein

S000003136
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187464-187796:1:exon

YGL168W
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
gene: HUR1
locus tag: YGL168W
note: ARS709; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay
SIO_010081: YGL168W
subclass of: SO_0000673
so part of: YGL168W
location: 187464..187796
location: region:187464-187796:1
so has part: feature:187464-187796:1:exon

S000130163
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187464-187796:1:exon

YGL167C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BSD1
alternative label: LDB1
alternative label: SSC1
gene: PMR1
locus tag: YGL167C
gene synonym: BSD1; LDB1; SSC1
so part of: sequence
location: complement(<187616..>190468)
location: region:187616-190468:-1
so has part: feature:187616-190468:-1:exon
subclass of: SO_0000010

852709
type: Gene
SIO_000068: ncbigene

position:187616:-1
position: 187616
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:190468:-1
position: 190468
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:187616-190468:-1:exon

YGL167C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BSD1
alternative label: LDB1
alternative label: SSC1
gene: PMR1
locus tag: YGL167C
gene synonym: BSD1; LDB1; SSC1
product: Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
transcript id: NM_001181032.1
SIO_010081: YGL167C
subclass of: SO_0000673
so part of: YGL167C
location: complement(<187616..>190468)
location: region:187616-190468:-1
so has part: feature:187616-190468:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:187616-190468:-1:exon

YGL167C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BSD1
alternative label: LDB1
alternative label: SSC1
gene: PMR1
locus tag: YGL167C
gene synonym: BSD1; LDB1; SSC1
EC number: 7.2.2.10
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:24124599|PMID:9092527]
experiment: EXISTENCE:direct assay:GO:0005388 P-type calcium transporter activity [PMID:10545175]
experiment: EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:10545175]
experiment: EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10545175]
experiment: EXISTENCE:direct assay:GO:0006828 manganese ion transport [PMID:10801856]
experiment: EXISTENCE:direct assay:GO:0140613 P-type manganese transporter activity [PMID:10801856]
experiment: EXISTENCE:genetic interaction:GO:0006874 cellular calcium ion homeostasis [PMID:23569283]
experiment: EXISTENCE:genetic interaction:GO:0030026 cellular manganese ion homeostasis [PMID:29632074]
experiment: EXISTENCE:mutant phenotype:GO:0005388 P-type calcium transporter activity [PMID:10545175|PMID:1379856]
experiment: EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:10545175]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:29632074]
note: High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant
codon start: 1
product: Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1
translation: MSDNPFNASLLDEDSNREREILDATAEALSKPSPSLEYCTLSVDEALEKLDTDKNGGLRSSNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSAVVSLFMGNIDDAVSITLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQESHVLASTLVPGDLVHFRIGDRIPADIRIIEAIDLSIDESNLTGENEPVHKTSQTIEKSSFNDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGMICLVGIIQGRSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKLNVLSLDKNKKTKNSNGNLKNYLTEDVRETLTIGNLCNNASFSQEHAIFLGNPTDVALLEQLANFEMPDIRNTVQKVQELPFNSKRKLMATKILNPVDNKCTVYVKGAFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSMASEGLRVFGFAKLTLSDSSTPLTEDLIKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNIAKQIGIPVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPRKRTDKILTHDVMKRLLTTAACIIVGTVYIFVKEMAEDGKVTARDTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPFFQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTRKKNEEDSTYFSNV
SIO_010081: YGL167C
subclass of: SO_0000673
so part of: YGL167C
location: complement(187616..190468)
location: region:187616-190468:-1
so has part: feature:187616-190468:-1:exon

NP_011348.1
type: Protein
SIO_000068: ncbiprotein

S000003135
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:187616-190468:-1:exon

YGL166W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ACE1
gene: CUP2
locus tag: YGL166W
gene synonym: ACE1
so part of: sequence
location: <191129..>191806
location: region:191129-191806:1
so has part: feature:191129-191806:1:exon
subclass of: SO_0000010

852710
type: Gene
SIO_000068: ncbigene

position:191129:1
position: 191129
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:191806:1
position: 191806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:191129-191806:1:exon

YGL166W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ACE1
gene: CUP2
locus tag: YGL166W
gene synonym: ACE1
product: Cup2p
transcript id: NM_001181031.3
SIO_010081: YGL166W
subclass of: SO_0000673
so part of: YGL166W
location: <191129..>191806
location: region:191129-191806:1
so has part: feature:191129-191806:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:191129-191806:1:exon

YGL166W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ACE1
gene: CUP2
locus tag: YGL166W
gene synonym: ACE1
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:2653812|PMID:2674688|PMID:3052856]
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:3052856]
experiment: EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:2068093]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2651899]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:3052856]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:2674688]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:29604179]
experiment: EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:3043194]
note: Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
codon start: 1
product: Cup2p
translation: MVVINGVKYACETCIRGHRAAQCTHTDGPLQMIRRKGRPSTTCGHCKELRRTKNFNPSGGCMCASARRPAVGSKEDETRCRCDEGEPCKCHTKRKSSRKSKGGSCHRRANDEAAHVNGLGIADLDVLLGLNGRSSDVDMTTTLPSLKPPLQNGEIKADSIDNLDLASLDPLEQSPSISMEPVSINETGSAYTTTNTALNDIDIPFSINELNELYKQVSSHNSHSQ
SIO_010081: YGL166W
subclass of: SO_0000673
so part of: YGL166W
location: 191129..191806
location: region:191129-191806:1
so has part: feature:191129-191806:1:exon

NP_011349.3
type: Protein
SIO_000068: ncbiprotein

S000003134
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:191129-191806:1:exon

YGL164C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YRB30
locus tag: YGL164C
so part of: sequence
location: complement(<191978..>193300)
location: region:191978-193300:-1
so has part: feature:191978-193300:-1:exon
subclass of: SO_0000010

852712
type: Gene
SIO_000068: ncbigene

position:191978:-1
position: 191978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:193300:-1
position: 193300
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:191978-193300:-1:exon

YGL164C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YRB30
locus tag: YGL164C
product: Yrb30p
transcript id: NM_001181029.1
SIO_010081: YGL164C
subclass of: SO_0000673
so part of: YGL164C
location: complement(<191978..>193300)
location: region:191978-193300:-1
so has part: feature:191978-193300:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:191978-193300:-1:exon

YGL164C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YRB30
locus tag: YGL164C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12578832]
experiment: EXISTENCE:direct assay:GO:0030695 GTPase regulator activity [PMID:12578832]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12578832]
note: RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
codon start: 1
product: Yrb30p
translation: MDEILAKAGSQAVTFAIKSGISIASTYALKTITNFVVQIPKDDARRIDQLKFKLESRMAIVSSAIDLIKLVAARGNTNLQITLRLTKDLKEEIDRFDEKINEMTQKVEGSRSAKTQNEAIKAVENYIKDLLLRIEEITPFINLSLTTSGANLNSALPYQLSPGLLLKASDFVSENNRKYEKAMKSNEKGTGDKEILKVQVGPTFEVTLFSIFYNLTSENNGQSGIVWKEDMKRAKARIYRLNSTGRKYDYFMKIEQDFNDGRYHEDDDKEDTPQELAIDLNHIKKLFFSVSGKLLRLEEQDSPVLVLKIDRSDDKENESSEGDKGLLDDITWYAVSGYEAIEEDEEEDEEEDEEEGKDGEERKEEEEEENKLEDKDSSITLLEYIIRLTSLQSNDQKSILEVSDERLSIYLNDENTNSRKDRISNSTIEETEKKLKNLKL
SIO_010081: YGL164C
subclass of: SO_0000673
so part of: YGL164C
location: complement(191978..193300)
location: region:191978-193300:-1
so has part: feature:191978-193300:-1:exon

NP_011351.1
type: Protein
SIO_000068: ncbiprotein

S000003132
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:191978-193300:-1:exon

YGL163C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: XRS1
gene: RAD54
locus tag: YGL163C
gene synonym: XRS1
so part of: sequence
location: complement(<193707..>196403)
location: region:193707-196403:-1
so has part: feature:193707-196403:-1:exon
subclass of: SO_0000010

852713
type: Gene
SIO_000068: ncbigene

position:193707:-1
position: 193707
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196403:-1
position: 196403
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:193707-196403:-1:exon

YGL163C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: XRS1
gene: RAD54
locus tag: YGL163C
gene synonym: XRS1
product: DNA-dependent ATPase RAD54
transcript id: NM_001181028.1
SIO_010081: YGL163C
subclass of: SO_0000673
so part of: YGL163C
location: complement(<193707..>196403)
location: region:193707-196403:-1
so has part: feature:193707-196403:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:193707-196403:-1:exon

YGL163C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: XRS1
gene: RAD54
locus tag: YGL163C
gene synonym: XRS1
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12577053]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10506208]
experiment: EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:10506208]
experiment: EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:10506208]
experiment: EXISTENCE:direct assay:GO:0032079 positive regulation of endodeoxyribonuclease activity [PMID:19129197]
experiment: EXISTENCE:direct assay:GO:0032392 DNA geometric change [PMID:10506208]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12399378]
note: DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress
codon start: 1
product: DNA-dependent ATPase RAD54
translation: MARRRLPDRPPNGIGAGERPRLVPRPINVQDSVNRLTKPFRVPYKNTHIPPAAGRIATGSDNIVGGRSLRKRSATVCYSGLDINADEAEYNSQDISFSQLTKRRKDALSAQRLAKDPTRLSHIQYTLRRSFTVPIKGYVQRHSLPLTLGMKKKITPEPRPLHDPTDEFAIVLYDPSVDGEMIVHDTSMDNKEEESKKMIKSTQEKDNINKEKNSQEERPTQRIGRHPALMTNGVRNKPLRELLGDSENSAENKKKFASVPVVIDPKLAKILRPHQVEGVRFLYRCVTGLVMKDYLEAEAFNTSSEDPLKSDEKALTESQKTEQNNRGAYGCIMADEMGLGKTLQCIALMWTLLRQGPQGKRLIDKCIIVCPSSLVNNWANELIKWLGPNTLTPLAVDGKKSSMGGGNTTVSQAIHAWAQAQGRNIVKPVLIISYETLRRNVDQLKNCNVGLMLADEGHRLKNGDSLTFTALDSISCPRRVILSGTPIQNDLSEYFALLSFSNPGLLGSRAEFRKNFENPILRGRDADATDKEITKGEAQLQKLSTIVSKFIIRRTNDILAKYLPCKYEHVIFVNLKPLQNELYNKLIKSREVKKVVKGVGGSQPLRAIGILKKLCNHPNLLNFEDEFDDEDDLELPDDYNMPGSKARDVQTKYSAKFSILERFLHKIKTESDDKIVLISNYTQTLDLIEKMCRYKHYSAVRLDGTMSINKRQKLVDRFNDPEGQEFIFLLSSKAGGCGINLIGANRLILMDPDWNPAADQQALARVWRDGQKKDCFIYRFISTGTIEEKIFQRQSMKMSLSSCVVDAKEDVERLFSSDNLRQLFQKNENTICETHETYHCKRCNAQGKQLKRAPAMLYGDATTWNHLNHDALEKTNDHLLKNEHHYNDISFAFQYISH
SIO_010081: YGL163C
subclass of: SO_0000673
so part of: YGL163C
location: complement(193707..196403)
location: region:193707-196403:-1
so has part: feature:193707-196403:-1:exon

NP_011352.1
type: Protein
SIO_000068: ncbiprotein

S000003131
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:193707-196403:-1:exon

YGL162W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUT1
locus tag: YGL162W
so part of: sequence
location: <198138..>199037
location: region:198138-199037:1
so has part: feature:198138-199037:1:exon
subclass of: SO_0000010

852714
type: Gene
SIO_000068: ncbigene

position:198138:1
position: 198138
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:199037:1
position: 199037
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198138-199037:1:exon

YGL162W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SUT1
locus tag: YGL162W
product: Sut1p
transcript id: NM_001181027.1
SIO_010081: YGL162W
subclass of: SO_0000673
so part of: YGL162W
location: <198138..>199037
location: region:198138-199037:1
so has part: feature:198138-199037:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198138-199037:1:exon

YGL162W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SUT1
locus tag: YGL162W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11248676|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23872066]
experiment: EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11401714]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23223039]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19793923]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11401714]
note: Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication
codon start: 1
product: Sut1p
translation: MSTSITVRNRDRSLPPLLLPNVSLLEKDIRRKGTQNVGITDPELLSTTWTRKRAFPTDELLGGYKRLKPAAADSNECAIGIATVTPPPTLPVSAIVPPPQNYTPPLFEYHPHALASMVNEDANASCTQMSIISRSTSNSTTSSATSTSSISKRQRSGPSCDKCRLKKIKCNAKIEILLQDDTIMPMISNKLRYVLTPDDIRLYRGTLLRNIAIPDDVIEGTGSRKLIKHIDKLVLLTPCLPCIKKKHSSSSTNFPKNDKCTFSKGFTRADINISSKISLKFKDKTIYDITYDDYKSIDF
SIO_010081: YGL162W
subclass of: SO_0000673
so part of: YGL162W
location: 198138..199037
location: region:198138-199037:1
so has part: feature:198138-199037:1:exon

NP_011353.1
type: Protein
SIO_000068: ncbiprotein

S000003130
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198138-199037:1:exon

YGL161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YIP5
locus tag: YGL161C
so part of: sequence
location: complement(<199210..>200142)
location: region:199210-200142:-1
so has part: feature:199210-200142:-1:exon
subclass of: SO_0000010

852715
type: Gene
SIO_000068: ncbigene

position:199210:-1
position: 199210
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:200142:-1
position: 200142
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:199210-200142:-1:exon

YGL161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YIP5
locus tag: YGL161C
product: Yip5p
transcript id: NM_001181026.3
SIO_010081: YGL161C
subclass of: SO_0000673
so part of: YGL161C
location: complement(<199210..>200142)
location: region:199210-200142:-1
so has part: feature:199210-200142:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:199210-200142:-1:exon

YGL161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YIP5
locus tag: YGL161C
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17178117]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11943201]
note: Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
codon start: 1
product: Yip5p
translation: MPSNNSSFLDIDDDLEGVDDFGNEPNPFDDATVPDSPNMNNSTAGKGSEFYNTTGSKAESAPLQGQMDPPAYDQVIGQNDNDGLGRNGLRPGLINYYSKYFQIDLTQFKKRLSAVLTFRNDHNSESNEDNTDLYGAVWITATVVMINFTMSRGLNFIISDVIEGVKTGEDIDRASQFKKLLHSIWLFYGYTFGVPFITMQVLNRDEHSERNRSFKSVPELISVYGYANLIWIPVCVILNILDMSKRLRTVQAIQWAIVALGWAQSSYFLNSQISSNNNTETQSNGKFSLSIIVVVALHTLFCLLFRFIIF
SIO_010081: YGL161C
subclass of: SO_0000673
so part of: YGL161C
location: complement(199210..200142)
location: region:199210-200142:-1
so has part: feature:199210-200142:-1:exon

NP_011354.3
type: Protein
SIO_000068: ncbiprotein

S000003129
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:199210-200142:-1:exon

YGL160W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YNO1
gene: AIM14
locus tag: YGL160W
gene synonym: YNO1
so part of: sequence
location: <200561..>202273
location: region:200561-202273:1
so has part: feature:200561-202273:1:exon
subclass of: SO_0000010

852716
type: Gene
SIO_000068: ncbigene

position:200561:1
position: 200561
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:202273:1
position: 202273
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:200561-202273:1:exon

YGL160W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YNO1
gene: AIM14
locus tag: YGL160W
gene synonym: YNO1
product: putative metalloreductase
transcript id: NM_001181025.1
SIO_010081: YGL160W
subclass of: SO_0000673
so part of: YGL160W
location: <200561..>202273
location: region:200561-202273:1
so has part: feature:200561-202273:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:200561-202273:1:exon

YGL160W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YNO1
gene: AIM14
locus tag: YGL160W
gene synonym: YNO1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:22586098]
experiment: EXISTENCE:genetic interaction:GO:0006915 apoptotic process [PMID:22586098]
experiment: EXISTENCE:mutant phenotype:GO:0016175 superoxide-generating NAD(P)H oxidase activity [PMID:22586098]
experiment: EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:22586098]
note: NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
codon start: 1
product: putative metalloreductase
translation: MKESPLITLVKRHSETHFANIKYGYYVLIISLVYLIGLALLRAFGRRTPSRSSSAFKNKIIYRLYDIDPAIHLGILFFAVLIPFYYHYSLTTQSTVYLKRLGRLSYALIPLNLFLTLRPNWFLRKNCTYTDFIPFHKWFSRIITVIGLLHGIFFIIKWAIDDNVSLKQKLILKTFNFAGFIISILVLFLLICSIGPMRRYNYRLFYIVHNLVNVAFILLTPIHSRPGVKFPFLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKTNLVHVRLPRAILPDYFEPGSHIRISPYRRINPLYWLLPSHPYTIASLAEDNSIDLIIKETSTAEPGSQIESLRSNPKSFHLDQEKTYTLINSYPPSVPEECYSQGTNIAIICGGSGISFALPLFRHFFNKENVKYLKMIWLIKDYSEYELVLDYLKTNGLTFEKKLSNNKRISVFISGEYTAETRLDEITTNIDDENSEYEMGSFNNEDEDLSISNFNSENADSNDNTPETSHSPTKENGSMIEVKSKHSFTLSNELKSFNNESAQVNQNETWLFSCGPPSLLQLSKKYCNDERINFVCETYGL
SIO_010081: YGL160W
subclass of: SO_0000673
so part of: YGL160W
location: 200561..202273
location: region:200561-202273:1
so has part: feature:200561-202273:1:exon

NP_011355.1
type: Protein
SIO_000068: ncbiprotein

S000003128
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:200561-202273:1:exon

YGL159W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL159W
so part of: sequence
location: <202721..>203833
location: region:202721-203833:1
so has part: feature:202721-203833:1:exon
subclass of: SO_0000010

852717
type: Gene
SIO_000068: ncbigene

position:202721:1
position: 202721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:203833:1
position: 203833
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202721-203833:1:exon

YGL159W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL159W
product: uncharacterized protein
transcript id: NM_001181024.1
SIO_010081: YGL159W
subclass of: SO_0000673
so part of: YGL159W
location: <202721..>203833
location: region:202721-203833:1
so has part: feature:202721-203833:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:202721-203833:1:exon

YGL159W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL159W
note: hypothetical protein; deletion mutant has no detectable phenotype
codon start: 1
product: uncharacterized protein
translation: MNNSIITDDEVREFYLNCSSQTIIESLLSLHESLRLYSQNHEILLNRMFKKLDETNADSNISHIFMPVVSKDFSGIKILVNNNNKNFQGVINVIEPETGKLIGCFEAKQITAIRTALASCIGLYKQLSCSHDKLFRFENGTCYLTCFGTGLQAFWHIYIAIKLIMSGIVGESLKLVEINILYHNNMMSLDRLKSLKNLFGSNIKIELNQYQINDISSEGNGAVSNSDIIFGCLPTLEPNLFLRQLLNSKASVEQKHTYISLIGSYKPVMHECDKELIDKFKSDNESACILVDSREHTLLESGELIDSNIAPHNLIEIGELDTLKNTVLNLNEKGCKRTITLCKIVGLAVMDVALAKEFLSLRTKNTENKE
SIO_010081: YGL159W
subclass of: SO_0000673
so part of: YGL159W
location: 202721..203833
location: region:202721-203833:1
so has part: feature:202721-203833:1:exon

NP_011356.1
type: Protein
SIO_000068: ncbiprotein

S000003127
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202721-203833:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS710; Autonomously Replicating Sequence
so part of: sequence
location: 203914..204155
location: region:203914-204155:1
so has part: feature:203914-204155:1:region

S000118454
type: SGD
SIO_000068: sgd

position:203914:1
position: 203914
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:204155:1
position: 204155
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:203914-204155:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 204982..205337
location: region:204982-205337:1
so has part: feature:204982-205337:1:region

S000006951
type: SGD
SIO_000068: sgd

position:204982:1
position: 204982
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:205337:1
position: 205337
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:204982-205337:1:region

YNCG0008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0008W
so part of: sequence
location: 205521..205634
location: region:205521-205634:1
so has part: feature:205521-205634:1:exon
subclass of: SO_0000663

852718
type: Gene
SIO_000068: ncbigene

position:205521:1
position: 205521
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:205634:1
position: 205634
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205521-205634:1:exon

YNCG0008W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0008W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0008W
subclass of: SO_0000673
so part of: YNCG0008W
location: join(205521..205558,205591..205634)
location: region:205521-205634:1
so has part: feature:205521-205558:1:exon
so has part: feature:205591-205634:1:exon

S000006639
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205521-205558:1:exon

position:205558:1
position: 205558
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:205591-205634:1:exon

position:205591:1
position: 205591
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL158W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RCK1
locus tag: YGL158W
so part of: sequence
location: <207033..>208571
location: region:207033-208571:1
so has part: feature:207033-208571:1:exon
subclass of: SO_0000010

852719
type: Gene
SIO_000068: ncbigene

position:207033:1
position: 207033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:208571:1
position: 208571
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:207033-208571:1:exon

YGL158W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RCK1
locus tag: YGL158W
product: putative serine/threonine protein kinase RCK1
transcript id: NM_001181023.1
SIO_010081: YGL158W
subclass of: SO_0000673
so part of: YGL158W
location: <207033..>208571
location: region:207033-208571:1
so has part: feature:207033-208571:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:207033-208571:1:exon

YGL158W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RCK1
locus tag: YGL158W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]
experiment: EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10778743]
note: Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
codon start: 1
product: putative serine/threonine protein kinase RCK1
translation: MSVNPEFIADGIDFYPTTPDAAYFNAADGKNKVNRINGNSENLHHSFASGCRRSSLSVDFNVTSSDSEKSEQSCLENNSQEDEYFCDIFSTELKLDETSNKSTDYSSSNHQYPEQLELHNYKLLNKIGEGAFSRVFKAVGINTDDQAPVAIKAIIKKGISSDAILKGNDRIQGSSRKKVLNEVAIHKLVSKNNPHCTKFIAFQESANYYYLVTELVTGGEIFDRIVQLTCFSEDLARHVITQVAIAIKHMHYMGIVHRDVKPENLLFEPIPFYGLDGDMQKEDEFTLGVGGGGIGLVKLMDFGLAKKLRNNTAKTPCGTIEYVASEVFTSKRYSMKVDMWSIGCVLFTLLCGYPPFYEKNEKTLLKKISRGDYEFLAPWWDNISSGAKNAVTHLLEVDPNKRYDIDDFLNDPWLNSYDCLKDSNSNSYASVQSILNDSFDERAETLHCALSCQSEKQDDTEFSRSESSEYIFMTEEDRNLRGSWIGEPKECFTLDLATSSIYRRRKNKIFFW
SIO_010081: YGL158W
subclass of: SO_0000673
so part of: YGL158W
location: 207033..208571
location: region:207033-208571:1
so has part: feature:207033-208571:1:exon

NP_011357.1
type: Protein
SIO_000068: ncbiprotein

S000003126
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:207033-208571:1:exon

YGL157W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARI1
locus tag: YGL157W
so part of: sequence
location: <209006..>210049
location: region:209006-210049:1
so has part: feature:209006-210049:1:exon
subclass of: SO_0000010

852720
type: Gene
SIO_000068: ncbigene

position:209006:1
position: 209006
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210049:1
position: 210049
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:209006-210049:1:exon

YGL157W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARI1
locus tag: YGL157W
product: carbonyl reductase (NADPH-dependent) ARI1
transcript id: NM_001181022.3
SIO_010081: YGL157W
subclass of: SO_0000673
so part of: YGL157W
location: <209006..>210049
location: region:209006-210049:1
so has part: feature:209006-210049:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:209006-210049:1:exon

YGL157W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARI1
locus tag: YGL157W
experiment: EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:19577617|PMID:19016485]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:14574691]
note: NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
codon start: 1
product: carbonyl reductase (NADPH-dependent) ARI1
translation: MTTDTTVFVSGATGFIALHIMNDLLKAGYTVIGSGRSQEKNDGLLKKFNNNPKLSMEIVEDIAAPNAFDEVFKKHGKEIKIVLHTASPFHFETTNFEKDLLTPAVNGTKSILEAIKKYAADTVEKVIVTSSTAALVTPTDMNKGDLVITEESWNKDTWDSCQANAVAAYCGSKKFAEKTAWEFLKENKSSVKFTLSTINPGFVFGPQMFADSLKHGINTSSGIVSELIHSKVGGEFYNYCGPFIDVRDVSKAHLVAIEKPECTGQRLVLSEGLFCCQEIVDILNEEFPQLKGKIATGEPATGPSFLEKNSCKFDNSKTKKLLGFQFYNLKDCIVDTAAQMLEVQNEA
SIO_010081: YGL157W
subclass of: SO_0000673
so part of: YGL157W
location: 209006..210049
location: region:209006-210049:1
so has part: feature:209006-210049:1:exon

NP_011358.3
type: Protein
SIO_000068: ncbiprotein

S000003125
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:209006-210049:1:exon

YGL156W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AMS1
locus tag: YGL156W
so part of: sequence
location: <210416..>213667
location: region:210416-213667:1
so has part: feature:210416-213667:1:exon
subclass of: SO_0000010

852721
type: Gene
SIO_000068: ncbigene

position:210416:1
position: 210416
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:213667:1
position: 213667
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210416-213667:1:exon

YGL156W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AMS1
locus tag: YGL156W
product: alpha-mannosidase
transcript id: NM_001181021.1
SIO_010081: YGL156W
subclass of: SO_0000673
so part of: YGL156W
location: <210416..>213667
location: region:210416-213667:1
so has part: feature:210416-213667:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210416-213667:1:exon

YGL156W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AMS1
locus tag: YGL156W
EC number: 3.2.1.24
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:3281936]
experiment: EXISTENCE:direct assay:GO:0004559 alpha-mannosidase activity [PMID:3281936]
experiment: EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:12479808|PMID:20659891]
experiment: EXISTENCE:mutant phenotype:GO:0009313 oligosaccharide catabolic process [PMID:12723970]
experiment: EXISTENCE:mutant phenotype:GO:0019309 mannose catabolic process [PMID:26947009]
note: Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway
codon start: 1
product: alpha-mannosidase
translation: MSSEDIIYDPQFKPVQGIYENRLRQFIDTGGDYHDLNLPKFYDKKRISLDHDHVKVWWYQVSFERGSSPVSPDKRPSWKSIIERDKKGELEFREANINQPFGPSWSTTWFKVKISLPEDWVKSNEQLLFQWDCSNEGIVIDPKTLIPVTAFSGGERTEYVLPKTSDGKHFFYIEAGNNGMFGCGAGSTINPPDDNRFFHLRKADIVWPDLDARALYIDFWMLGDAARELPGDSWQKHQARQLGNAVMNLFDPNDRSSVRKCRELLQREYFDSFLESSKVYEQGESQVLTNVYGIGNCHIDTAWLWPFAETRRKIVRSWSSQCTLMDRFPEYKFVASQAQQFKWLLEDHPEFFNKVLIPKIQQSQFFAVGGTWVENDTNIPSGESLARQFFFGQRFFLKHFGLKSKIFWLPDTFGYSSQMPQLCRLSGIDKFLTQKLSWNNINSFPHSTFNWAGIDGSQLLTHMPPGNTYTADSHFGDVLRTAKQNKTPEYYGSGLMLYGKGDGGGGPTEEMLQKMRRIRSMNNRNGNVIPKLQVGITVDEFYDDILKRTNQGHDLPTWSGELYFEFHRGTYTSQAQTKKLMRLSEIKLHDLEWIAAKTSVLYPDSYKYPSKQINELWENVLLCQFHDVLPGSCIEMVYKYEAVPMLHNVVKECTSLIDKTVQFLQSQSKADLVEMRTLTWSKPEKVSEECSLNGSYTSSVTGYDDYIVLANGKLKVIICKKTGVITSITDETLGVEYLDTEHGRNKLGANQFVIYDDKPLGWQAWDTELYSVNQYKYVTKPKKVQVSCNTKEKCAVEVIFQISEKCKIKSVISLNATAVTDAKLSKVDISTTVENWDARNKFLKVEFPVNIRNDFASYETQFGITKRPTHYNTSWDVAKFEVCHHKFADYSEYSKGVSILNDCKYGFSTHGNLMRLSLLRSPKAPDAHADMGTHEIKYAIYPHRGALSSDTVKLAHEFNYCFKYKLPKDIGMNFDDIISISGDENVILSNIKRGEDDSAVKSNYSLNPRDEQSIVVRVYESLGGESFASLNTTLNLKRIEKVDNLEMKVYKSLTATRDESNHAINRIPIKLRPFEIASFRLYF
SIO_010081: YGL156W
subclass of: SO_0000673
so part of: YGL156W
location: 210416..213667
location: region:210416-213667:1
so has part: feature:210416-213667:1:exon

NP_011359.1
type: Protein
SIO_000068: ncbiprotein

S000003124
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210416-213667:1:exon

YGL155W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CAL1
gene: CDC43
locus tag: YGL155W
gene synonym: CAL1
so part of: sequence
location: <214081..>215211
location: region:214081-215211:1
so has part: feature:214081-215211:1:exon
subclass of: SO_0000010

852722
type: Gene
SIO_000068: ncbigene

position:214081:1
position: 214081
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:215211:1
position: 215211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214081-215211:1:exon

YGL155W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CAL1
gene: CDC43
locus tag: YGL155W
gene synonym: CAL1
product: protein geranylgeranyltransferase type I subunit CDC43
transcript id: NM_001181020.1
SIO_010081: YGL155W
subclass of: SO_0000673
so part of: YGL155W
location: <214081..>215211
location: region:214081-215211:1
so has part: feature:214081-215211:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214081-215211:1:exon

YGL155W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CAL1
gene: CDC43
locus tag: YGL155W
gene synonym: CAL1
EC number: 2.5.1.59
experiment: EXISTENCE:direct assay:GO:0004662 CAAX-protein geranylgeranyltransferase activity [PMID:1400380]
experiment: EXISTENCE:direct assay:GO:0005953 CAAX-protein geranylgeranyltransferase complex [PMID:1400380]
experiment: EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:2034682]
note: Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
codon start: 1
product: protein geranylgeranyltransferase type I subunit CDC43
translation: MCQATNGPSRVVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFDVNVSAKYGDHLGWMRKHYIKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEYFETILDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYICGCRSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTITWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQTELVTNYLLDRTQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGELCIPQEIFNDFSKRCCF
SIO_010081: YGL155W
subclass of: SO_0000673
so part of: YGL155W
location: 214081..215211
location: region:214081-215211:1
so has part: feature:214081-215211:1:exon

NP_011360.1
type: Protein
SIO_000068: ncbiprotein

S000003123
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214081-215211:1:exon

YGL154C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LYS5
locus tag: YGL154C
so part of: sequence
location: complement(<215278..>216096)
location: region:215278-216096:-1
so has part: feature:215278-216096:-1:exon
subclass of: SO_0000010

852723
type: Gene
SIO_000068: ncbigene

position:215278:-1
position: 215278
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:216096:-1
position: 216096
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215278-216096:-1:exon

YGL154C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LYS5
locus tag: YGL154C
product: holo-[acyl-carrier-protein] synthase
transcript id: NM_001181019.1
SIO_010081: YGL154C
subclass of: SO_0000673
so part of: YGL154C
location: complement(<215278..>216096)
location: region:215278-216096:-1
so has part: feature:215278-216096:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:215278-216096:-1:exon

YGL154C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LYS5
locus tag: YGL154C
EC number: 2.7.8.7
experiment: EXISTENCE:direct assay:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:10320345]
experiment: EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:3921525]
note: Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
codon start: 1
product: holo-[acyl-carrier-protein] synthase
translation: MVKTTEVVSEVSKVAGVRPWAGIFVVEIQEDILADEFTFEALMRTLPLASQARILNKKSFHDRCSNLCSQLLQLFGCSIVTGLNFQELKFDKGSFGKPFLDNNRFLPFSMTIGEQYVAMFLVKCVSTDEYQDVGIDIASPCNYGGREELELFKEVFSEREFNGLLKASDPCTIFTYLWSLKESYTKFTGTGLNTDLSLIDFGAISFFPAEGASMCITLDEVPLIFHSQWFNNEIVTICMPKSISDKINTNRPKLYNISLSTLIDYFIENDGL
SIO_010081: YGL154C
subclass of: SO_0000673
so part of: YGL154C
location: complement(215278..216096)
location: region:215278-216096:-1
so has part: feature:215278-216096:-1:exon

NP_011361.1
type: Protein
SIO_000068: ncbiprotein

S000003122
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:215278-216096:-1:exon

YGL153W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEX14
locus tag: YGL153W
so part of: sequence
location: <216273..>217298
location: region:216273-217298:1
so has part: feature:216273-217298:1:exon
subclass of: SO_0000010

852724
type: Gene
SIO_000068: ncbigene

position:216273:1
position: 216273
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:217298:1
position: 217298
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:216273-217298:1:exon

YGL153W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEX14
locus tag: YGL153W
product: Pex14p
transcript id: NM_001181018.3
SIO_010081: YGL153W
subclass of: SO_0000673
so part of: YGL153W
location: <216273..>217298
location: region:216273-217298:1
so has part: feature:216273-217298:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:216273-217298:1:exon

YGL153W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEX14
locus tag: YGL153W
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9094717|PMID:9312008]
experiment: EXISTENCE:direct assay:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717]
experiment: EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831|PMID:12667447]
experiment: EXISTENCE:mutant phenotype:GO:0016560 protein import into peroxisome matrix, docking [PMID:16107331]
experiment: EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717|PMID:9312008|PMID:16107331]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:9094717|PMID:9312008]
experiment: EXISTENCE:physical interaction:GO:0097027 ubiquitin-protein transferase activator activity [PMID:9094717]
note: Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
codon start: 1
product: Pex14p
translation: MSDVVSKDRKALFDSAVSFLKDESIKDAPLLKKIEFLKSKGLTEKEIEIAMKEPKKDGIVGDEVSKKIGSTENRASQDMYLYEAMPPTLPHRDWKDYFVMATATAGLLYGAYEVTRRYVIPNILPEAKSKLEGDKKEIDDQFSKIDTVLNAIEAEQAEFRKKESETLKELSDTIAELKQALVQTTRSREKIEDEFRIVKLEVVNMQNTIDKFVSDNDGMQELNNIQKEMESLKSLMNNRMESGNAQDNRLFSISPNGIPGIDTIPSASEILAKMGMQEESDKEKENGSDANKDDNAVPAWKKAREQTIDSNASIPEWQKNTAANEISVPDWQNGQVEDSIP
SIO_010081: YGL153W
subclass of: SO_0000673
so part of: YGL153W
location: 216273..217298
location: region:216273-217298:1
so has part: feature:216273-217298:1:exon

NP_011362.3
type: Protein
SIO_000068: ncbiprotein

S000003121
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:216273-217298:1:exon

YGL151W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MED5
alternative label: SSX4
gene: NUT1
locus tag: YGL151W
gene synonym: MED5; SSX4
so part of: sequence
location: <217524..>220922
location: region:217524-220922:1
so has part: feature:217524-220922:1:exon
subclass of: SO_0000010

852726
type: Gene
SIO_000068: ncbigene

position:217524:1
position: 217524
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:220922:1
position: 220922
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:217524-220922:1:exon

YGL151W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MED5
alternative label: SSX4
gene: NUT1
locus tag: YGL151W
gene synonym: MED5; SSX4
product: Nut1p
transcript id: NM_001181016.1
SIO_010081: YGL151W
subclass of: SO_0000673
so part of: YGL151W
location: <217524..>220922
location: region:217524-220922:1
so has part: feature:217524-220922:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:217524-220922:1:exon

YGL151W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MED5
alternative label: SSX4
gene: NUT1
locus tag: YGL151W
gene synonym: MED5; SSX4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9671481|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19368889]
experiment: EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:19368889]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9671481]
note: Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription
codon start: 1
product: Nut1p
translation: MEKESVYNLALKCAERQLTSMEFSNLYKEFFNEKFPSLIQEEEEDTTTTANINEVKKASDLVDTPSNNTAATADTTHLHEALDIVCSDFVKILNLEKPLILADYIVEVLLVNYNSDMIKCFLPKLNSVRNSLLLAHFFSKSCSFFAKLSDTLIIDQVRKDLGNVIVPNILSLDMNSMNKELIAIVSKLLQTTLKLSPSPILLTSAGCKNGSFTLLNQLSQTNKLLFKRVSQTFEAKLHFKDTKPFLNKDSTNEFVGSPSLTSPQYIPSPLSSTKPPGSVNSAAKYKDMKLLRYYKNIWLNNKIINWEISNPDFLSKYSAITSSIFQESFNSVQNLDQLLTDLIETSFTCFAQFVSNKQYHQANSNLTLLERKWVIFITKHLPLLILENSSRSPRVVTNALDNIDEKVVKAIRIYFTEKDDNKTNNEDLFDDYPSTSLDIRHDFIKGLIMLNLQPASVINNYLREDQMIDTSILPTRDDLFVRNLQGIQEVVHNTNSFIISSLDTLELESITESITHDSSNGLFQVLHNFESVAPTKQREIVKAFLSIFEDAIKELNYNRIAKICALLFFNFSHSLTTILSFSSPAALMKTLIKFVDLSRNGRNGSNGNDESSEYETINISLSFSWAILLIINLTQTYGISVVDVALKYPELSIKNSFIINFISNLPNVSDKYYLEESNVNDSDMLTKSHNTVQSWLCDLFVNGSITDQLIQNIETRQLANLIPFIVKQVLLSVEIGVLTDISSLIGGFEYFLQPLLLVGLIKTFYWLEQFLSCVKNDTISEDILQGIFNLLNTLFNPVTLNEDSKAFHTAVLRLNAIPLLKVLRKFRVQSQSNYGIYSSDAQGDPNLEPLIAKLVAVLNVSPVYDVDPRIINSENDYSRKQLGYGKFLILNENPINKIMTNQINSFWSLHSSTYYNLDYLFELIELVTPKSFLFDVLKTLEYKLATYGVPGSENKRGSLDSEHVFDYFFYFLVLYDVKTAEEASQLIEYMENDAKKSKGDVDIKGEDLHEKNDSAEVRQETQPKAEATQDDDFDMLFGENDTSTQAYEEEEENEDNDGNNRTNNVPMIKAEETPSKTNKISILKRHSFAVLLHERKLLNDLALENGEITKTENEKFISYHDKYLCMLKTCVF
SIO_010081: YGL151W
subclass of: SO_0000673
so part of: YGL151W
location: 217524..220922
location: region:217524-220922:1
so has part: feature:217524-220922:1:exon

NP_011364.1
type: Protein
SIO_000068: ncbiprotein

S000003119
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:217524-220922:1:exon

YGL150C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: INO80
locus tag: YGL150C
so part of: sequence
location: complement(<221104..>225573)
location: region:221104-225573:-1
so has part: feature:221104-225573:-1:exon
subclass of: SO_0000010

852728
type: Gene
SIO_000068: ncbigene

position:221104:-1
position: 221104
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225573:-1
position: 225573
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221104-225573:-1:exon

YGL150C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: INO80
locus tag: YGL150C
product: chromatin-remodeling ATPase INO80
transcript id: NM_001181015.1
SIO_010081: YGL150C
subclass of: SO_0000673
so part of: YGL150C
location: complement(<221104..>225573)
location: region:221104-225573:-1
so has part: feature:221104-225573:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221104-225573:-1:exon

YGL150C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: INO80
locus tag: YGL150C
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:10952318]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:10952318]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:10952318]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:10952318]
experiment: EXISTENCE:direct assay:GO:0019222 regulation of metabolic process [PMID:29462149]
experiment: EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:10361278]
experiment: EXISTENCE:direct assay:GO:0035065 regulation of histone acetylation [PMID:29462149]
experiment: EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:10952318]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10952318]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23207916]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:10952318]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:18258182]
experiment: EXISTENCE:mutant phenotype:GO:0032006 regulation of TOR signaling [PMID:29462149]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17681272]
note: Nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity; involved in positioning and spacing of nucleosomes over most genes independently of transcription; promotes nucleosome shifts in the 3' direction; has a role in modulating stress gene transcription
codon start: 1
product: chromatin-remodeling ATPase INO80
translation: MSLAVLLNKEDKDISDFSKTTAGKSAKKNSRERVADVAPTRVLDKKQAYLSQLNSEFNRIKRRDSIEQLYQDWKFINLQEFELISEWNQQSKDWQFDNTNDSQDLHFKKLYRDMSMINKEWAEYQSFKNANLSDIINEKDADEDEEDDEDELEDGEEDMEEDEASTGRHTNGKSMRGNGIQKSRKKDAAAAAAIGKAIKDDQTHADTVVTVNGDENEDGNNGEDEDNDNDNENNNDNDNDNENENDNDSDNDDEEENGEEDEEEEEIEDLDEEDFAAFEEQDDNDDEDFNPDVEKRRKRSSSSSSSTKLSMNSLSLITSKKINKNITINSDRPKIVRELIKMCNKNKHQKIKKRRFTNCIVTDYNPIDSKLNIKITLKQYHVKRLKKLINDAKREREREEALKNNVGLDGNDLDNDEDGSESHKRRKLNNNTANGADDANKRKFNTRHGLPTYGMKMNAKEARAIQRHYDNTYTTIWKDMARKDSTKMSRLVQQIQSIRSTNFRKTSSLCAREAKKWQSKNFKQIKDFQTRARRGIREMSNFWKKNEREERDLKKKIEKEAMEQAKKEEEEKESKRQAKKLNFLLTQTELYSHFIGRKIKTNELEGNNVSSNDSESQKNIDISALAPNKNDFHAIDFDNENDEQLRLRAAENASNALAETRAKAKQFDDHANAHEEEEEEDELNFQNPTSLGEITIEQPKILACTLKEYQLKGLNWLANLYDQGINGILADEMGLGKTVQSISVLAHLAENHNIWGPFLVVTPASTLHNWVNEISKFLPQFKILPYWGNANDRKVLRKFWDRKNLRYNKNAPFHVMVTSYQMVVTDANYLQKMKWQYMILDEAQAIKSSQSSRWKNLLSFHCRNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFNEWFSKDIESHAEANTKLNQQQLRRLHMILKPFMLRRVKKNVQSELGDKIEIDVLCDLTQRQAKLYQVLKSQISTNYDAIENAATNDSTSNSASNSGSDQNLINAVMQFRKVCNHPDLFERADVDSPFSFTTFGKTTSMLTASVANNNSSVISNSNMNLSSMSSNNISNGKFTDLIYSSRNPIKYSLPRLIYEDLILPNYNNDVDIANKLKNVKFNIFNPSTNYELCLFLSKLTGEPSLNEFFRVSTTPLLKRVIERTNGPKNTDSLSFKTITQELLEVTRNAPSEGVMASLLNVEKHAYEREYLNCIQRGYHPNVSAPPVTIEVLGSSHVTNSINNELFDPLISQALSDIPAITQYNMHVKKGIPVEDFPKTGLFPEPLNKNFSSNISMPSMDRFITESAKLRKLDELLVKLKSEGHRVLIYFQMTKMMDLMEEYLTYRQYNHIRLDGSSKLEDRRDLVHDWQTNPEIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLLVRGTIEERMRDRAKQKEQVQQVVMEGKTQEKNIKTIEVGENDSEVTREGSKSISQDGIKEAASALA
SIO_010081: YGL150C
subclass of: SO_0000673
so part of: YGL150C
location: complement(221104..225573)
location: region:221104-225573:-1
so has part: feature:221104-225573:-1:exon

NP_011365.1
type: Protein
SIO_000068: ncbiprotein

S000003118
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221104-225573:-1:exon

YGL149W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL149W
so part of: sequence
location: <225572..>225877
location: region:225572-225877:1
so has part: feature:225572-225877:1:exon
subclass of: SO_0000010

852727
type: Gene
SIO_000068: ncbigene

position:225572:1
position: 225572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225877:1
position: 225877
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:225572-225877:1:exon

YGL149W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL149W
product: uncharacterized protein
transcript id: NM_001348834.1
SIO_010081: YGL149W
subclass of: SO_0000673
so part of: YGL149W
location: <225572..>225877
location: region:225572-225877:1
so has part: feature:225572-225877:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225572-225877:1:exon

YGL149W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL149W
note: hypothetical protein; conserved among S. cerevisiae strains; YGL149W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSINALLYVLSLALLIWTGSVVTLLLLLFFCLFLLFFSLHFFCFTREHVHYTLPPKCHSLKFQFDSIPSSSLSLSPFPFLFFPRLRAVAFASPTLSFFFPI
SIO_010081: YGL149W
subclass of: SO_0000673
so part of: YGL149W
location: 225572..225877
location: region:225572-225877:1
so has part: feature:225572-225877:1:exon

NP_001335775.1
type: Protein
SIO_000068: ncbiprotein

S000003117
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225572-225877:1:exon

YGL148W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARO2
locus tag: YGL148W
so part of: sequence
location: <226399..>227529
location: region:226399-227529:1
so has part: feature:226399-227529:1:exon
subclass of: SO_0000010

852729
type: Gene
SIO_000068: ncbigene

position:226399:1
position: 226399
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:227529:1
position: 227529
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226399-227529:1:exon

YGL148W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARO2
locus tag: YGL148W
product: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
transcript id: NM_001181013.1
SIO_010081: YGL148W
subclass of: SO_0000673
so part of: YGL148W
location: <226399..>227529
location: region:226399-227529:1
so has part: feature:226399-227529:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:226399-227529:1:exon

YGL148W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARO2
locus tag: YGL148W
EC number: 4.2.3.5
experiment: EXISTENCE:direct assay:GO:0004107 chorismate synthase activity [PMID:8971708]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19793921|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0042602 riboflavin reductase (NADPH) activity [PMID:8971708]
experiment: EXISTENCE:mutant phenotype:GO:0004107 chorismate synthase activity [PMID:8971708]
experiment: EXISTENCE:mutant phenotype:GO:0009073 aromatic amino acid family biosynthetic process [PMID:8971708]
note: Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
codon start: 1
product: bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2
translation: MSTFGKLFRVTTYGESHCKSVGCIVDGVPPGMSLTEADIQPQLTRRRPGQSKLSTPRDEKDRVEIQSGTEFGKTLGTPIAMMIKNEDQRPHDYSDMDKFPRPSHADFTYSEKYGIKASSGGGRASARETIGRVASGAIAEKFLAQNSNVEIVAFVTQIGEIKMNRDSFDPEFQHLLNTITREKVDSMGPIRCPDASVAGLMVKEIEKYRGNKDSIGGVVTCVVRNLPTGLGEPCFDKLEAMLAHAMLSIPASKGFEIGSGFQGVSVPGSKHNDPFYFEKETNRLRTKTNNSGGVQGGISNGENIYFSVPFKSVATISQEQKTATYDGEEGILAAKGRHDPAVTPRAIPIVEAMTALVLADALLIQKARDFSRSVVH
SIO_010081: YGL148W
subclass of: SO_0000673
so part of: YGL148W
location: 226399..227529
location: region:226399-227529:1
so has part: feature:226399-227529:1:exon

NP_011367.1
type: Protein
SIO_000068: ncbiprotein

S000003116
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:226399-227529:1:exon

YGL147C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL9A
locus tag: YGL147C
so part of: sequence
location: complement(<227754..>228329)
location: region:227754-228329:-1
so has part: feature:227754-228329:-1:exon
subclass of: SO_0000010

852730
type: Gene
SIO_000068: ncbigene

position:227754:-1
position: 227754
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228329:-1
position: 228329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:227754-228329:-1:exon

YGL147C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL9A
locus tag: YGL147C
product: ribosomal 60S subunit protein L9A
transcript id: NM_001181012.3
SIO_010081: YGL147C
subclass of: SO_0000673
so part of: YGL147C
location: complement(<227754..>228329)
location: region:227754-228329:-1
so has part: feature:227754-228329:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:227754-228329:-1:exon

YGL147C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL9A
locus tag: YGL147C
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
note: Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog, RPL9B, that arose from a single-locus duplication
codon start: 1
product: ribosomal 60S subunit protein L9A
translation: MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGGRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFITEDL
SIO_010081: YGL147C
subclass of: SO_0000673
so part of: YGL147C
location: complement(227754..228329)
location: region:227754-228329:-1
so has part: feature:227754-228329:-1:exon

NP_011368.3
type: Protein
SIO_000068: ncbiprotein

S000003115
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:227754-228329:-1:exon

YGL146C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRT6
locus tag: YGL146C
so part of: sequence
location: complement(<228751..>229686)
location: region:228751-229686:-1
so has part: feature:228751-229686:-1:exon
subclass of: SO_0000010

852731
type: Gene
SIO_000068: ncbigene

position:228751:-1
position: 228751
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229686:-1
position: 229686
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228751-229686:-1:exon

YGL146C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRT6
locus tag: YGL146C
product: Rrt6p
transcript id: NM_001181011.1
SIO_010081: YGL146C
subclass of: SO_0000673
so part of: YGL146C
location: complement(<228751..>229686)
location: region:228751-229686:-1
so has part: feature:228751-229686:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228751-229686:-1:exon

YGL146C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRT6
locus tag: YGL146C
note: Integral membrane protein, member of the p24 family; forms complex with Erp3p, Erp5p, and Emp24p; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
codon start: 1
product: Rrt6p
translation: MEKASLNIAQTKEIPLTDRRMGLRGWKACSRPHLLGRILLFMSILFITSAELSSDVSSREVYMPIFNNKLSFKVPPIKRSLLLGAALYEDFEYSSNNSASDGAFCTVFNAGMNDASREVVFEIHVMDVLQEETDSSRFGGTSHERGRQSLGFSVFNNKNGDLLRSKKNLASGTSVIEVNPGNCNEFLICFINLVYDGSWSSIDTEKSVTIKMTYNDKLDPDMLLHLVNQMTPQVVKALNTVSDGLFQIVSDTTLLQMESDRRDINEATYSYLIVGFVSLMVAQLISNIIVTTYLIIKIKSNPSSHIKKKGL
SIO_010081: YGL146C
subclass of: SO_0000673
so part of: YGL146C
location: complement(228751..229686)
location: region:228751-229686:-1
so has part: feature:228751-229686:-1:exon

NP_011369.1
type: Protein
SIO_000068: ncbiprotein

S000003114
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228751-229686:-1:exon

YGL145W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TIP1
gene: TIP20
locus tag: YGL145W
gene synonym: TIP1
so part of: sequence
location: <230243..>232348
location: region:230243-232348:1
so has part: feature:230243-232348:1:exon
subclass of: SO_0000010

852732
type: Gene
SIO_000068: ncbigene

position:230243:1
position: 230243
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:232348:1
position: 232348
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:230243-232348:1:exon

YGL145W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TIP1
gene: TIP20
locus tag: YGL145W
gene synonym: TIP1
product: Tip20p
transcript id: NM_001181010.2
SIO_010081: YGL145W
subclass of: SO_0000673
so part of: YGL145W
location: <230243..>232348
location: region:230243-232348:1
so has part: feature:230243-232348:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:230243-232348:1:exon

YGL145W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TIP1
gene: TIP20
locus tag: YGL145W
gene synonym: TIP1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11739780]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9639310]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:30837368]
experiment: EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]
note: Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
codon start: 1
product: Tip20p
translation: MNGIDDLLNINDRIKQVQNERNELASKLQNLKQSLASNDTEVALSEVIAQDIIEVGASVEGLEQLRAKYGDLQILNKLEKVAVQQTQMQAGVDKLDSFERQLDELAEQPPDQFTLDDVKALHSKLTSVFATVPQINNIDSQYAAYNKLKSKVTGKYNDVIIQRLATNWSNTFDQKLLEAQWDTQKFASTSVGLVKCLRENSTKLYQLSLLYLPLEEETQNGDSERPLSRSNNNQEPVLWNFKSLANNFNVRFTYHFHATSSSSKIETYFQFLNDYLAENLYKCINIFHDDCNGLTKPVIHEQFINYVLQPIRDKVRSTLFQNDLKTLIVLISQILATDKNLLNSFHYHGLGLVSLISDEVWEKWINYEVEMANRQFINITKNPEDFPKSSQNFVKLINKIYDYLEPFYDLDFDLLVRYKLMTCSLIFMNLTSSYLDYILTVDSLNETRTKEQELYQTMAKLQHVNFVYRKIKSLSSNFIFIQLTDIVNSTESKKYNSLFQNVENDYEKAMSTDMQNSIVHRIQKLLKETLRNYFKISTWSTLEMSVDENIGPSSVPSAELVNSINVLRRLINKLDSMDIPLAISLKVKNELLNVIVNYFTESILKLNKFNQNGLNQFLHDFKSLSSILSLPSHATNYKCMSLHELVKILKLKYDPNNQQFLNPEYIKTGNFTSLKEAYSIKYLKDTKIQDALYRIIYGNIL
SIO_010081: YGL145W
subclass of: SO_0000673
so part of: YGL145W
location: 230243..232348
location: region:230243-232348:1
so has part: feature:230243-232348:1:exon

NP_116577.1
type: Protein
SIO_000068: ncbiprotein

S000003113
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:230243-232348:1:exon

YGL145W
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
alternative label: TIP1
gene: TIP20
locus tag: YGL145W
gene synonym: TIP1
note: ARS701; ARS containing only an imperfect match to the core consensus sequence
SIO_010081: YGL145W
subclass of: SO_0000673
so part of: YGL145W
location: 231907..231981
location: region:231907-231981:1
so has part: feature:231907-231981:1:exon

S000007642
type: SGD
SIO_000068: sgd

position:231907:1
position: 231907
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:231981:1
position: 231981
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:231907-231981:1:exon

YGL144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ROG1
locus tag: YGL144C
so part of: sequence
location: complement(<232450..>234507)
location: region:232450-234507:-1
so has part: feature:232450-234507:-1:exon
subclass of: SO_0000010

852733
type: Gene
SIO_000068: ncbigene

position:232450:-1
position: 232450
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:234507:-1
position: 234507
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232450-234507:-1:exon

YGL144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ROG1
locus tag: YGL144C
product: putative lipase ROG1
transcript id: NM_001181009.1
SIO_010081: YGL144C
subclass of: SO_0000673
so part of: YGL144C
location: complement(<232450..>234507)
location: region:232450-234507:-1
so has part: feature:232450-234507:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232450-234507:-1:exon

YGL144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ROG1
locus tag: YGL144C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25433290]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25433290]
experiment: EXISTENCE:direct assay:GO:0047372 acylglycerol lipase activity [PMID:25433290]
experiment: EXISTENCE:mutant phenotype:GO:0044255 cellular lipid metabolic process [PMID:25433290]
note: Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species
codon start: 1
product: putative lipase ROG1
translation: MSLTPTNEILFHYKSSVKVGELERYVITYHLYDGEEIPPDLNLNSLWLKVRNMNPLSYRAAYLMGPFMLYCDVKTAQYHHSQKIVASVDYPKFEPNVQTQQDFVAELSVHNIRQKYVWIADVMSQILFTTNTNVTYEVTIGTSKESVENPHDLPSHLGSYSPKLTVNRLTTLDLWNLPVQITTPQKKKHLVVLTHGLHSNVSTDLVYIMEQIYKAQKNYPHEQIVVKGYRGNVCQTEKGVKYLGTRLAEYIIQDLYDESIRKISFVGHSLGGLIQAFAIAYIYEVYPWFFKKVNPINFITLASPLLGIVTDNPAYIKVLLSFGVIGKTGQDLGLENDVEVGKPLLYLLSGLPLIEILRRFKRRTVYANAINDGIVPLYTASLLFLDYNDILEQLQKLKENSKKSPLINDASTPVNQDFFNKTFISPLTKMLSILAPQKFPTENGSEIPKVSFFESASSILLPPLPERAYIMDPDSRDPVIIHDKIYNEDDIPQSEFDIEDGFFGKKNILLQAFFAGKKERAKYRNLEETIARRWHEGMAWRKVVVALKPDAHNNIIVRRKFANAYGWPVIDHLIDVHFNGDDDDDNDENDDINSTQVVEPIQSVTEGKKKYRKAENIPQEYGWLNKVETNGVFDEGPTGMISTVGEIVEALAKRGFSAVIDRRNASEDPNDEVLRFEEMNSDLVQ
SIO_010081: YGL144C
subclass of: SO_0000673
so part of: YGL144C
location: complement(232450..234507)
location: region:232450-234507:-1
so has part: feature:232450-234507:-1:exon

NP_011371.1
type: Protein
SIO_000068: ncbiprotein

S000003112
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232450-234507:-1:exon

YGL143C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRF1
locus tag: YGL143C
so part of: sequence
location: complement(<234717..>235958)
location: region:234717-235958:-1
so has part: feature:234717-235958:-1:exon
subclass of: SO_0000010

852734
type: Gene
SIO_000068: ncbigene

position:234717:-1
position: 234717
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235958:-1
position: 235958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234717-235958:-1:exon

YGL143C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRF1
locus tag: YGL143C
product: Mrf1p
transcript id: NM_001181008.3
SIO_010081: YGL143C
subclass of: SO_0000673
so part of: YGL143C
location: complement(<234717..>235958)
location: region:234717-235958:-1
so has part: feature:234717-235958:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234717-235958:-1:exon

YGL143C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRF1
locus tag: YGL143C
experiment: EXISTENCE:direct assay:GO:0003747 translation release factor activity [PMID:10748224]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:8265342|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0003747 translation release factor activity [PMID:1475194]
experiment: EXISTENCE:genetic interaction:GO:0070126 mitochondrial translational termination [PMID:1475194]
experiment: EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1475194]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:1475194]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:14734569]
experiment: EXISTENCE:mutant phenotype:GO:0070126 mitochondrial translational termination [PMID:15827612]
note: Mitochondrial translation release factor RF1; involved in stop codon recognition and hydrolysis of peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
codon start: 1
product: Mrf1p
translation: MWLSKFQFPSRSIFKGVFLGHKLPLLVRLTSTTTNSKSNGSIPTQYTELSPLLVKQAEKYEAELKDLDKDLSCGIHFDVNKQKHYAKLSALTDTFIEYKEKLNELKSLQEMIVSDPSLRAEAEQEYAELVPQYETTSSRLVNKLLPPHPFADKPSLLELRPGVGGIEAMIFTQNLLDMYIGYANYRKWKYRIISKNENESGSGIIDAILSIEEAGSYDRLRFEAGVHRVQRIPSTETKGRTHTSTAAVVVLPQIGDESAKSIDAYERTFKPGEIRVDIMRASGKGGQHVNTTDSAVRLTHIPSGIVVSMQDERSQHKNKAKAFTILRARLAEKERLEKEEKERKARKSQVSSTNRSDKIRTYNFPQNRITDHRCGFTLLDLPGVLSGERLDEVIEAMSKYDSTERAKELLESN
SIO_010081: YGL143C
subclass of: SO_0000673
so part of: YGL143C
location: complement(234717..235958)
location: region:234717-235958:-1
so has part: feature:234717-235958:-1:exon

NP_011372.3
type: Protein
SIO_000068: ncbiprotein

S000003111
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234717-235958:-1:exon

YGL142C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPI10
locus tag: YGL142C
so part of: sequence
location: complement(<236269..>238119)
location: region:236269-238119:-1
so has part: feature:236269-238119:-1:exon
subclass of: SO_0000010

852735
type: Gene
SIO_000068: ncbigene

position:236269:-1
position: 236269
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238119:-1
position: 238119
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:236269-238119:-1:exon

YGL142C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPI10
locus tag: YGL142C
product: putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
transcript id: NM_001181007.1
SIO_010081: YGL142C
subclass of: SO_0000673
so part of: YGL142C
location: complement(<236269..>238119)
location: region:236269-238119:-1
so has part: feature:236269-238119:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:236269-238119:-1:exon

YGL142C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPI10
locus tag: YGL142C
experiment: EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9639537|PMID:9576863]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:9759715]
note: Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog
codon start: 1
product: putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase
translation: MAHEVHRIKPKLGRTQIFWVFLAFRVLNAVLTRTFFQADEFWQALEPAHWKAFKYGELTWEWKFGVRSYLFPMIFELTYRLVSLSSILLHYALLLLSTIGSDLLILLLPKYELSWQVAEDLKRLPFDVTRSFEYYGVIYAPKIVMAVLASIGEYYIVRFVQKLYLLTLDKRNEKEEEERRSGLSEITKFALLLSLTNFFNCFFITRTFINSFEMILTSIALYYWDWTGGQMIKESSFTKSLIFAFLACLQRPSSGLIWVIPSISLILNLVGKKQYHLLFITFSKVLRSFFLVFTANAIIDMYFYEKVTFPFFRFLKFNFTTPLSKFYGVAPWHFHFFQSLPIVLGASIPAFAFGLFFPLSKRSFPKKYLNPFFQVKLTILLNLLVYSTLPHKEFRFIFPLQPLFILISSFGLLRLDRDYWKRLSGLKSLLWLVPFVSVFIALLLDTFHESGSIEVMKFLHEEPEIDSLGFIMPCHSTPGQSYLHRSDIQDLWSITCNPPLHLLGDPEAYSKLETYMDESDHLYDDISAFIYKNFPPPFRKDLRSPGKTYSHEWPTYLVVFEHMENAFLKDFLKDSSYIEYNRFFNSLAHWDSRRSGDIIIYYKLPFDYSDIPAADI
SIO_010081: YGL142C
subclass of: SO_0000673
so part of: YGL142C
location: complement(236269..238119)
location: region:236269-238119:-1
so has part: feature:236269-238119:-1:exon

NP_011373.1
type: Protein
SIO_000068: ncbiprotein

S000003110
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:236269-238119:-1:exon

YGL141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HUL5
locus tag: YGL141W
so part of: sequence
location: <238353..>241085
location: region:238353-241085:1
so has part: feature:238353-241085:1:exon
subclass of: SO_0000010

852736
type: Gene
SIO_000068: ncbigene

position:238353:1
position: 238353
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241085:1
position: 241085
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:238353-241085:1:exon

YGL141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HUL5
locus tag: YGL141W
product: ubiquitin-ubiquitin ligase HUL5
transcript id: NM_001181006.1
SIO_010081: YGL141W
subclass of: SO_0000673
so part of: YGL141W
location: <238353..>241085
location: region:238353-241085:1
so has part: feature:238353-241085:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:238353-241085:1:exon

YGL141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HUL5
locus tag: YGL141W
EC number: 2.3.2.26
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:17190603]
experiment: EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:12408819]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:17190603]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756]
experiment: EXISTENCE:mutant phenotype:GO:0010994 free ubiquitin chain polymerization [PMID:22497224]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:17190603]
note: Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock
codon start: 1
product: ubiquitin-ubiquitin ligase HUL5
translation: MLNFTGQTRRRNVNLGNRTRNSKKDLLEKAKRERERRAQDKLKEDASKTIQKSIRRHFSNVRLFKNTFTSSQLVHMIPAYGGKLIYYISQYDLQQLLKLSHNFLSSYPNSLGNRQLLSLLKLYQDDALVAETLSDLNMDCPTVDEFLDSLSVYLCRASFLSYSSASKLADVIEAWEVMHSSASISIFSISIGSYEKRPFALQFYCILAERNLLPQLINTNPILWDNMAKTYSHCSKGGQKNIAKLLIPNFNNHIAPSVLRSDNDYVLKFYEKAFIDEVIATTANYVSDEDHVKNLMCYIASSPNQSCKNSVLITLLSNKDFVRRLSWEFFHTKFNASKTEAHPLFSVLAQLIDMHLLISTDRELLDYNSVIPIEELKKFTSTLKDFTFRQYWELPKSERNPMLKEAVPLLSKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQEYEDLYREHLEEESDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSLRFRKLEILLELPFFIPFEERVDLFYMFIALDKKRLSLDDDHNLINMFTPWASTGMRKQSAIISRDNVLEDAFNAFNSIGERFKASLDVTFINEFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYELYPSVVYDATKLKYIWFLGKVVGKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSLDLTFEIDEPESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAPHWMEMFNSIELQMLISGERDNIDLDDLKSNTEYGGYKEEDQTIVDFWEVLNEFKFEEKLNFLKFVTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGARFDLS
SIO_010081: YGL141W
subclass of: SO_0000673
so part of: YGL141W
location: 238353..241085
location: region:238353-241085:1
so has part: feature:238353-241085:1:exon

NP_011374.1
type: Protein
SIO_000068: ncbiprotein

S000003109
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:238353-241085:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS712; Replication origin; identified in multiple array studies, confirmed by plasmid-based recombinational ARS assay
so part of: sequence
location: 241085..241353
location: region:241085-241353:1
so has part: feature:241085-241353:1:region

S000130164
type: SGD
SIO_000068: sgd

position:241353:1
position: 241353
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241085-241353:1:region

YGL140C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL140C
so part of: sequence
location: complement(<241353..>245012)
location: region:241353-245012:-1
so has part: feature:241353-245012:-1:exon
subclass of: SO_0000010

852737
type: Gene
SIO_000068: ncbigene

position:241353:-1
position: 241353
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:245012:-1
position: 245012
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:241353-245012:-1:exon

YGL140C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL140C
product: uncharacterized protein
transcript id: NM_001181005.1
SIO_010081: YGL140C
subclass of: SO_0000673
so part of: YGL140C
location: complement(<241353..>245012)
location: region:241353-245012:-1
so has part: feature:241353-245012:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:241353-245012:-1:exon

YGL140C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL140C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; non-essential gene; contains multiple predicted transmembrane domains
codon start: 1
product: uncharacterized protein
translation: MSLKSKLTKIQKLWLYYFPCDRILAKRICKSTVNTTVAFIFCLIPKITAHLGAAPAMLPMISVIVHPGRRVGGTIHGAIYCITGLIFGLAYAIFGRFLAQRCLGSSWHELTEAQQHVLHYKRYEAGLAILAVFEVIMLFFHGWMRSVSHYYFGIVFPLFVVVHFAFMDPLNETAGTIAKAYSTPFYLGIAMSIFWNLVLFPEWGTTYLGNTTIDAMNELHKSIDYSINFFIAVDPHNSSQLYSRDPVSLGKLLKMKSLISSKVNNCRVVLHECIYEFTYAYVSPTKLKPIISTLENLTVFINGLVNTCQLEFILLARHDNKLRPDDVAALTLPKNKEISFANAEKLLKVIDKLHPVIYSLHRTMSECMYIAKLVLAHAFDVKVSRVHSCSMFKDGNFPTFSNNANNLPNDVDIQNKINDLKQALEECKAKFKSEMLSFDIDIMSPSDEMFLLSSFLLNFRQTADSTLVIMESVKDILVKRQIQEKKGWLRGKRLWFLVLTNYETFSIWLKGDRNSVTENDTLKGTFNGNTNGFAHDTVIRRPDYEENELLSQKVSSNKNIVKDDASLDLPMTSEPKGNSSSTSDTSSSPLTLTKTTTFGTNRTSRRQGRFSFMSMLISIDKFCEVSHPHFRFGFQVAIALMLASFPMFIPKTRQWYIDYRGTWIGFVCILCLEPSVGGTFWVFFLRAVGVIFGAAWGYLSYVAAVNQTNPYLETVITVFGAIPGFYYLLGTPYVKAAIIEIISIYIVMLAAILPSQDDILTSFAKRCLAVGYGGGVALIVQVFFFPLKAREQLNEEISFVCGCISEMELLYATGLEGEQVASSMSEEKYKKIEKISKSAKEALARATAYKGLTRQEPRLKGEYTELENVFTQVIFIQKQIIERIDTISLLRKQNGSAVIEEFNSVVYPYRRQMVGSISCLMRALQEAFINKTPLPQFLPSARIAHRRLINKVRQTLRIRYPGQISNLSDKARKPNEGDYADGKDEDDDDNEGLVMKMNRRGQANTTANPHEYVLKEKFLSWNASSAASEEIIEYIEELLNLTKILVGVNEFKYGFLSRPLYEDWAAEAVTGFDNFINGKSNPMNTRRNRTPFDGTSIISEGNESLQSTNSNESQISPDSTRSYEPECPVAYEKNDNPAALNLLRIASHKAGQNADGLPKTFRNRAFSITSTSGQLSSLSRHSTLGNADPNYLNDDDESSDDDLPLALKMVLSHMKEKKD
SIO_010081: YGL140C
subclass of: SO_0000673
so part of: YGL140C
location: complement(241353..245012)
location: region:241353-245012:-1
so has part: feature:241353-245012:-1:exon

NP_011375.1
type: Protein
SIO_000068: ncbiprotein

S000003108
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:241353-245012:-1:exon

YGL139W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FLC3
locus tag: YGL139W
so part of: sequence
location: <245716..>248124
location: region:245716-248124:1
so has part: feature:245716-248124:1:exon
subclass of: SO_0000010

852738
type: Gene
SIO_000068: ncbigene

position:245716:1
position: 245716
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248124:1
position: 248124
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:245716-248124:1:exon

YGL139W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FLC3
locus tag: YGL139W
product: putative flavin adenine dinucleotide transporter
transcript id: NM_001181004.3
SIO_010081: YGL139W
subclass of: SO_0000673
so part of: YGL139W
location: <245716..>248124
location: region:245716-248124:1
so has part: feature:245716-248124:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:245716-248124:1:exon

YGL139W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FLC3
locus tag: YGL139W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16717099]
experiment: EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]
note: Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication
codon start: 1
product: putative flavin adenine dinucleotide transporter
translation: MRFLQVYKSSALIGLIILLASKVNLAEAKRKLVATSLVTCMENSQLSANSFDVVFNPDDRSLHYDLDMSTQIDSYIFADIDVYAYGFKIITKNVDLCSINWKQFCPVHPGNIQIDSIEYISSEYVNEIPGIAYQVPDIDAYARVKITNNVSEYLACIQIYFSNGKTVSQIGVKWATAVVAGIGLLLSAILSTFGNSTAASHISANTMSLFLYFQSVVVVAMQHVHRVPPIAAAWAENLVWSMGLIRISFMQRIFRWYVQSTGGTPSLYLTSTSMSVLAQRSWQYLMELPLIKRATNVLYGNANTLIFRGIKRLGYKMGIENTSIVCTGFTFFVLCGYVLAGFIIVFKCCVELATRLGWIQKARFWEFRKQWRMILKGALLRYIYIGFVQLTILSFWEFTERDSPAVIVIACLFILLSCGLMLWAAWRTVFFARRSVALYNNPAALLYGDEYVLHKYGFFYTMFNANHYWWNIVLLSYIFVKSLLVGFAQASGQTQVLFMFILDLFYFVAIIYYKPYLDRPTNIMNILIATVTVVNSFLFMFFSDLFNQSYKVAAIMGWIFFIMNAAFSFILLMMILAFAGMMLFSKNPDLRFKPAKDDRTSFQRNTMKPEGTVNRSVANELLALGNVAKDHDDNSDYESNDTGVNDELKQAQDETTPTTVTSSDDNKPTFSEKILSKFSRPKNENASTDALRVEAPKQQTFPHNLTNLSRENLSTLGSKPYPGHTRSQSDAHNGLINSFEEEDTSSNTDPFHDSTEGDLLDTSSSDGGFRSQNYVRDDSINSLGNNKQPLRKPPGFFDEGFM
SIO_010081: YGL139W
subclass of: SO_0000673
so part of: YGL139W
location: 245716..248124
location: region:245716-248124:1
so has part: feature:245716-248124:1:exon

NP_011376.3
type: Protein
SIO_000068: ncbiprotein

S000003107
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:245716-248124:1:exon

YGL138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL138C
so part of: sequence
location: complement(<248494..>249531)
location: region:248494-249531:-1
so has part: feature:248494-249531:-1:exon
subclass of: SO_0000010

852739
type: Gene
SIO_000068: ncbigene

position:248494:-1
position: 248494
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:249531:-1
position: 249531
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:248494-249531:-1:exon

YGL138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL138C
product: uncharacterized protein
transcript id: NM_001181003.1
SIO_010081: YGL138C
subclass of: SO_0000673
so part of: YGL138C
location: complement(<248494..>249531)
location: region:248494-249531:-1
so has part: feature:248494-249531:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:248494-249531:-1:exon

YGL138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL138C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
note: hypothetical protein; has no significant sequence similarity to any known protein
codon start: 1
product: uncharacterized protein
translation: MYNFLEFFFFFITYTLFKSTFVQGKSSFPGHDVCKFEDQNFQTEFFLNVLKGDKLQNLKQEYEQYKKQSTLYTGFVIEKQYEYQVAPLQINNFLQVTFCKGGKPIWNHILPFQKDLDWAEPLCIPAQEDDTISQNSSVCFKFARVQKYTQRNVTLYFPNKFVGFVFVCNSSKTHPPTQNNFETIPLTPIISDDIRDYKISWSIKGRITKVVPYLHSLSIPMSKYEMLIHSDKNISNELEYKSLTSEFWKSYKNLRKFKNKEMSWINEINPMEQYDSSGNENVPNFHEKLDRTINRIAQNIERPHDALIRAIAAHNRNSNSGNITRRKYLRRKISKMLKNKIPLKN
SIO_010081: YGL138C
subclass of: SO_0000673
so part of: YGL138C
location: complement(248494..249531)
location: region:248494-249531:-1
so has part: feature:248494-249531:-1:exon

NP_011377.1
type: Protein
SIO_000068: ncbiprotein

S000003106
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:248494-249531:-1:exon

YGL137W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEC27
locus tag: YGL137W
so part of: sequence
location: <249869..>252738
location: region:249869-252738:1
so has part: feature:249869-252738:1:exon
subclass of: SO_0000010

852740
type: Gene
SIO_000068: ncbigene

position:249869:1
position: 249869
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:252738:1
position: 252738
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:249869-252738:1:exon

YGL137W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEC27
locus tag: YGL137W
product: coatomer subunit beta'
transcript id: NM_001181002.1
SIO_010081: YGL137W
subclass of: SO_0000673
so part of: YGL137W
location: join(<249869..249886,250087..>252738)
location: region:249869-252738:1
so has part: feature:249869-249886:1:exon
so has part: feature:250087-252738:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:249869-249886:1:exon

position:249886:1
position: 249886
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:250087-252738:1:exon

position:250087:1
position: 250087
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL137W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEC27
locus tag: YGL137W
experiment: EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:7929113]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:27068463]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]
experiment: EXISTENCE:physical interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]
note: Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
codon start: 1
product: coatomer subunit beta'
translation: MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYTLLFNKDAYLEAANNGNIDDSEGVDEAFDVLYELSESITSGKWVGDVFIFTTATNRLNYFVGGKTYNLAHYTKEMYLLGYLARDNKVYLADREVHVYGYEISLEVLEFQTLTLRGEIEEAIENVLPNVEGKDSLTKIARFLEGQEYYEEALNISPDQDQKFELALKVGQLTLARDLLTDESAEMKWRALGDASLQRFNFKLAVEAFTNAHDLESLFLLHSSFNNKEGLVTLAKDAERAGKFNLAFNAYWIAGDIQGAKDLLIKSQRFSEAAFLGSTYGLGDDAVNDIVTKWKENLILNGKNTVSERVCGAEGLPGSSSSGDAQPLIDLDSTPAPEQADENKEAEVEDSEFKESNSEAVEAEKKEEEAPQQQQSEQQPEQGEAVPEPVEEES
SIO_010081: YGL137W
subclass of: SO_0000673
so part of: YGL137W
location: join(249869..249886,250087..252738)
location: region:249869-252738:1
so has part: feature:249869-249886:1:exon
so has part: feature:250087-252738:1:exon

NP_011378.1
type: Protein
SIO_000068: ncbiprotein

S000003105
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:249869-249886:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:250087-252738:1:exon

YGL136C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRM2
locus tag: YGL136C
so part of: sequence
location: complement(<252897..>253859)
location: region:252897-253859:-1
so has part: feature:252897-253859:-1:exon
subclass of: SO_0000010

852741
type: Gene
SIO_000068: ncbigene

position:252897:-1
position: 252897
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253859:-1
position: 253859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:252897-253859:-1:exon

YGL136C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRM2
locus tag: YGL136C
product: 21S rRNA (uridine2791-2'-O) methyltransferase
transcript id: NM_001181001.1
SIO_010081: YGL136C
subclass of: SO_0000673
so part of: YGL136C
location: complement(<252897..>253859)
location: region:252897-253859:-1
so has part: feature:252897-253859:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:252897-253859:-1:exon

YGL136C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRM2
locus tag: YGL136C
EC number: 2.1.1.168
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11867542]
experiment: EXISTENCE:direct assay:GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity [PMID:11867542]
experiment: EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:11867542]
experiment: EXISTENCE:mutant phenotype:GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity [PMID:14636587|PMID:11867542]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:11867542|PMID:14636587]
note: Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
codon start: 1
product: 21S rRNA (uridine2791-2'-O) methyltransferase
translation: MILVYNRIRSIISSSLGRIHVRYNSNSQNRWLNRQLKDPYTKEAKVQNLRSRAAFKLMQIDDKYRLFSKNRTDQRILDLGYAPGAWSQVARQRSSPNSMILGVDILPCEPPHGVNSIQANILAKRTHDLIRLFFSKHFQLNRHDDLHKDHGYFQNMLEEELTHVKDTELYREIFTSDDIYETPNTNSTLIEREKFPVDVIISDMYEPWPQTTGFWNNITNQAYFRMANTSGVSIRDHYQSIDLCDAALVTAIDLLRPLGSFVCKLYTGEEENLFKKRMQAVFTNVHKFKPDASRDESKETYYIGLKKKRNVDKLDVFSNS
SIO_010081: YGL136C
subclass of: SO_0000673
so part of: YGL136C
location: complement(252897..253859)
location: region:252897-253859:-1
so has part: feature:252897-253859:-1:exon

NP_011379.1
type: Protein
SIO_000068: ncbiprotein

S000003104
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:252897-253859:-1:exon

YGL135W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSM2
gene: RPL1B
locus tag: YGL135W
gene synonym: SSM2
so part of: sequence
location: <254641..>255294
location: region:254641-255294:1
so has part: feature:254641-255294:1:exon
subclass of: SO_0000010

852742
type: Gene
SIO_000068: ncbigene

position:254641:1
position: 254641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:255294:1
position: 255294
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:254641-255294:1:exon

YGL135W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSM2
gene: RPL1B
locus tag: YGL135W
gene synonym: SSM2
product: ribosomal 60S subunit protein L1B
transcript id: NM_001181000.3
SIO_010081: YGL135W
subclass of: SO_0000673
so part of: YGL135W
location: <254641..>255294
location: region:254641-255294:1
so has part: feature:254641-255294:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:254641-255294:1:exon

YGL135W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSM2
gene: RPL1B
locus tag: YGL135W
gene synonym: SSM2
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:31439809]
note: Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins
codon start: 1
product: ribosomal 60S subunit protein L1B
translation: MSKITSSQVREHVKELLKYSNETKKRNFLETVELQVGLKNYDPQRDKRFSGSLKLPNCPRPNMSICIFGDAFDVDRAKSCGVDAMSVDDLKKLNKNKKLIKKLSKKYNAFIASEVLIKQVPRLLGPQLSKAGKFPTPVSHNDDLYGKVTDVRSTIKFQLKKVLCLAVAVGNVEMEEDVLVNQILMSVNFFVSLLKKNWQNVGSLVVKSSMGPAFRLY
SIO_010081: YGL135W
subclass of: SO_0000673
so part of: YGL135W
location: 254641..255294
location: region:254641-255294:1
so has part: feature:254641-255294:1:exon

NP_011380.3
type: Protein
SIO_000068: ncbiprotein

S000003103
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:254641-255294:1:exon

YGL134W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCL10
locus tag: YGL134W
so part of: sequence
location: <255663..>256964
location: region:255663-256964:1
so has part: feature:255663-256964:1:exon
subclass of: SO_0000010

852743
type: Gene
SIO_000068: ncbigene

position:255663:1
position: 255663
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256964:1
position: 256964
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:255663-256964:1:exon

YGL134W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCL10
locus tag: YGL134W
product: Pcl10p
transcript id: NM_001180999.1
SIO_010081: YGL134W
subclass of: SO_0000673
so part of: YGL134W
location: <255663..>256964
location: region:255663-256964:1
so has part: feature:255663-256964:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:255663-256964:1:exon

YGL134W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCL10
locus tag: YGL134W
experiment: EXISTENCE:direct assay:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:9584169]
experiment: EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9584169]
experiment: EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]
experiment: EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]
experiment: EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9584169]
note: Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication
codon start: 1
product: Pcl10p
translation: MDMTKNHTTDTEEFDDGDIRPVSLGIVDDYNASFELPLKPKFLQSENFSDLTSEWDQSRSNTPGLAEGKTEKAQPCGTTDSSKNRIHVEQLLESANEMNNYLAQNIENINNFQVGLLNGGKGLYSSMGDDSSACINGTNFSSTSNFELSDDELEDTTGCTSSIFDKDLFHQQNGLSIPRRRSPLFKSPTASFEIGDATDVEEQDIDDSIFSECSSITSFDMGGLHISLPHDEEEDQEKTKSESENPLLHGIPVDVEVPHISVDEALANFKETIELLLKLSGNRKCTGFNTRVEKKEYSNFYMKSKPTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGNNILQLKLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFSKVCGISKRLLTKLEVSLLICVCNTKLMVSNRKLAASKLLLNELRSFCV
SIO_010081: YGL134W
subclass of: SO_0000673
so part of: YGL134W
location: 255663..256964
location: region:255663-256964:1
so has part: feature:255663-256964:1:exon

NP_011381.1
type: Protein
SIO_000068: ncbiprotein

S000003102
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:255663-256964:1:exon

YGL133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ITC1
locus tag: YGL133W
so part of: sequence
location: <257707..>261501
location: region:257707-261501:1
so has part: feature:257707-261501:1:exon
subclass of: SO_0000010

852744
type: Gene
SIO_000068: ncbigene

position:257707:1
position: 257707
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:261501:1
position: 261501
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:257707-261501:1:exon

YGL133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ITC1
locus tag: YGL133W
product: Itc1p
transcript id: NM_001180998.1
SIO_010081: YGL133W
subclass of: SO_0000673
so part of: YGL133W
location: <257707..>261501
location: region:257707-261501:1
so has part: feature:257707-261501:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:257707-261501:1:exon

YGL133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ITC1
locus tag: YGL133W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12624196]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:14673157]
experiment: EXISTENCE:physical interaction:GO:0008623 CHRAC [PMID:14673157]
note: Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication
codon start: 1
product: Itc1p
translation: MVLYKRKPILLPDPKPLPLDLNVQVWHIEETGEWFSSYEEFLERFDFYTRHHFTCEITGTSCLTFFQALDSEETQFKYVEDRFPLKLREPVARFLHFNGIRRLDALVEKVYARFKNDFFPGEVVYLRKQKDSSTTSSNSQQSTPQPDDMVEINSVGNPGLPQYQYQRRYVIKEKVQFNATINPESREIVMPAHTKYMLIEEAASSNKSFIVDQGQIYRDRSTFTKHLIKCFFKITLQRASSKMGAPWCVKPEYLAMYGLTMEWPKDMLKYKEDEPVVARRSNSANVSSPESEKNKRQSKSSGKSNTSNDASNKKETKKKRKPTEVNDSENNSSEEDKKKGQNVTSETHSKKRKKEANEEPNTENVESVPTPANAEPQAVTITSIMDDLALPYQHPPNIFPNLTYYNEKLECISLGSTKLSRPFDSFGKLLQAYQFLNTFGSKICLSHFSLDQFITSLKCTDPYELKGEVVLVNIRTQTSKEQEIENNGLPMKNKAETTTEEDSENPSDWQRNSFIRDMIMKRNSDKVEYKIVHDDPASDDILDNINHNGSALLIEVFTALLRLFINEEGDWSCIVVENWIIDDKGVLMERKDERGEGEAKQKRNAHGYFLQDKEKIDNLKDTLKENATEVQKESDAKNETNSESDSKSDSDSEERDPKLEKCLNYRNVNWIERLTKRQFNNSYWLIILLGVLEDCRHLPMYTEFIDSFIEKIIPKDISATQLPKQLWRNFCRKLSFSDKVNALWILVDLVSHFSPDIKAAVDDSMELCGQIRSERFKVARELKTEAAVLSNLQGDLQAIQEKLNKTDENTPSADGADKKDDSESNSEPIDLIIIEKKQKLIEEQDKKVQALQSDKNFLDNCLFENDLQRLKPLGLDRYGNRYFWLDHNGVPFPQYPAGMNETPKSNNSLSYHSGRLLIQGPKASSAKFFLNVSDEQLSNWQKIRNSEGISEATREVFGISKTSSGSYNYVENGIEVELLDSNDRVNPLIELTPIQKKIMDETPSRLLLSPDQWYCIDKLEDLSRIMDWLDNWGRKEHDLLRQIRPIMERIKSSLSLRDHALSLTAFTKNEEKLLKELENNEFTENELNVDSMDVDDKNSGVKSEVDVQVDAEEKREAVIDEKLEVIADELMKLDDSSKTRNVLNRIQELEDQRDELLEQKKSIINSQRPGARILARSERKRTKISRGNKVNKQIEILTDLVNYRHFKAMEDVIAWKNVLANSIWGSSLRKNASGNKRSGVIETVDDKLKDIVGQTSRTVTPAPN
SIO_010081: YGL133W
subclass of: SO_0000673
so part of: YGL133W
location: 257707..261501
location: region:257707-261501:1
so has part: feature:257707-261501:1:exon

NP_011382.1
type: Protein
SIO_000068: ncbiprotein

S000003101
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:257707-261501:1:exon

YGL131C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNT2
locus tag: YGL131C
so part of: sequence
location: complement(<261648..>265859)
location: region:261648-265859:-1
so has part: feature:261648-265859:-1:exon
subclass of: SO_0000010

852746
type: Gene
SIO_000068: ncbigene

position:261648:-1
position: 261648
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:265859:-1
position: 265859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:261648-265859:-1:exon

YGL131C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNT2
locus tag: YGL131C
product: DNA-binding E3 ubiquitin-protein ligase SNT2
transcript id: NM_001180996.1
SIO_010081: YGL131C
subclass of: SO_0000673
so part of: YGL131C
location: complement(<261648..>265859)
location: region:261648-265859:-1
so has part: feature:261648-265859:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:261648-265859:-1:exon

YGL131C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNT2
locus tag: YGL131C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23878396]
experiment: EXISTENCE:direct assay:GO:0016574 histone ubiquitination [PMID:22570702]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22570702]
experiment: EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23878396]
experiment: EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]
note: Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: DNA-binding E3 ubiquitin-protein ligase SNT2
translation: MPKEEDFQLPRRREAAKNVNYNEMEIDTKLVQQIQIAEKSGAKTKGSNSQTPRNCKRTSNPASRNEKFKYQKFLHDKNTCWNFIPTLPPSFRKNSRFSNILDLDDAMIDLKKMSLFNTESVLLSANDTIYMISEPAGEPYYVGRVVNFVSKPEFSNTIHEAIKTTSVFPAKFFQVRMNWFYRPRDIQEHVNTFNPRLVYASLHQDICPISSYRGKCSIFHKDEVFDVLPNEKECIIRPNIFYFDELFDRYTLKYYKVYSTDKILNKWNSKSPFLYVLNRRFRYIYTEPKYPLENVLKKYVFHELEVNELSPADYQWDKRCQFCKEWCIQKESLSCDECGVCAHLYCMDPPLDRKPNKDVVWTCFSCLQKQQGTKDSHVRFLEEQALELDFIRSVRQKIEEISSKAIKENVGYNTENCWFQYLGIYSISHIGDALNDSMFFPYPFKPSRVGVKYQWNGCNHNVPWRRNSYISANSEEERGSTKTSELAWVLDASKITTRKLSEYIEQCKSEICPILNVRGETCNFIDVVLKNLLFTNYDTAEAFKKCKRELSRKFLKEPSFTAVEIRKFEEAVEKFGSELRPVCEYVGTQPMSMIVRFYYNWKKTERGLTVRGKLSKLSKNKRKKEIANHENDVETKYIDDSSFDTEKLSLAESSFQCMFCKTDYSPMWYRVTGGSDDEKIKIRMQTGVNEKTEISEKSPAHSKKNEKLGALCIRCARMWRRYAIKWVPPLETLRKITGTCQNSFYSAIEGIIEENNTNKFTLSPFQAHNKLLEWELVQDSELIIRQRMKVYKNPNSFVKMKRYSMTFHTQLYKMAVRSYRKNEFHPETMQRDLELFIEDNKEVRKAIPEQKPERAKNTKDEFPVNIIRQSPGTIKTSDTSRNRKCNDVFIEKASNNNIPKITNASNDLIEISIKTGGSSSGSVSVDKGFKFVKFDNKTFQRLRNSLKLVNNKLPKYNEPSTKKIKMINDIALSNPLNEPNGASYNYTVISHSKETSVALEKYHDGNKPSKMLEKDMILKHTKNKPKNPDTAWANNSARTFCSVCKEKFNDNDNYEVVCGNCGLTVHYFCYAIKLPKDMKKNTNLKTFKWLCDPCSNDLNPIISTTYQCSMCPTKDYDYDRYRSQSFKICPDALKCTSLGTWVHLVCSLFNEDIKYGNGQSMQPALNTTAVLIKHSRFTCGVCRINGGGLVKCNKCQYRYHITCAQNSSNFKLMFEKKNMSVDTTLPCIKDVKLNDTYTLRPILICDRHDISLEGNELYPLSYKPQHTLSYIEQYCRYYKCESDHSLVELRYFEQLRLRHGEMPGNSHDSAIKPKIYVLPFERTCPHCGTNKSLYWYEDIICHSCNLRSGAQELDFDSASANISNDNGLPVEITQQLMEGIEPAMFDIDISEAGTDKNTHPSSQ
SIO_010081: YGL131C
subclass of: SO_0000673
so part of: YGL131C
location: complement(261648..265859)
location: region:261648-265859:-1
so has part: feature:261648-265859:-1:exon

NP_011384.1
type: Protein
SIO_000068: ncbiprotein

S000003099
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:261648-265859:-1:exon

YGL130W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CEG1
locus tag: YGL130W
so part of: sequence
location: <266145..>267524
location: region:266145-267524:1
so has part: feature:266145-267524:1:exon
subclass of: SO_0000010

852747
type: Gene
SIO_000068: ncbigene

position:266145:1
position: 266145
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:267524:1
position: 267524
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:266145-267524:1:exon

YGL130W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CEG1
locus tag: YGL130W
product: mRNA guanylyltransferase
transcript id: NM_001180995.3
SIO_010081: YGL130W
subclass of: SO_0000673
so part of: YGL130W
location: <266145..>267524
location: region:266145-267524:1
so has part: feature:266145-267524:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:266145-267524:1:exon

YGL130W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CEG1
locus tag: YGL130W
EC number: 2.7.7.50
experiment: EXISTENCE:genetic interaction:GO:0031533 mRNA cap methyltransferase complex [PMID:9710603]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15226422]
experiment: EXISTENCE:mutant phenotype:GO:0004484 mRNA guanylyltransferase activity [PMID:8718687]
experiment: EXISTENCE:mutant phenotype:GO:0006370 7-methylguanosine mRNA capping [PMID:8718687]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15226422]
experiment: EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:9832501]
experiment: EXISTENCE:physical interaction:GO:0031533 mRNA cap methyltransferase complex [PMID:9710603]
note: Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant
codon start: 1
product: mRNA guanylyltransferase
translation: MVLAMESRVAPEIPGLIQPGNVTQDLKMMVCKLLNSPKPTKTFPGSQPVSFQHSDVEEKLLAHDYYVCEKTDGLRVLMFIVINPVTGEQGCFMIDRENNYYLVNGFRFPRLPQKKKEELLETLQDGTLLDGELVIQTNPMTKLQELRYLMFDCLAINGRCLTQSPTSSRLAHLGKEFFKPYFDLRAAYPNRCTTFPFKISMKHMDFSYQLVKVAKSLDKLPHLSDGLIFTPVKAPYTAGGKDSLLLKWKPEQENTVDFKLILDIPMVEDPSLPKDDRNRWYYNYDVKPVFSLYVWQGGADVNSRLKHFDQPFDRKEFEILERTYRKFAELSVSDEEWQNLKNLEQPLNGRIVECAKNQETGAWEMLRFRDDKLNGNHTSVVQKVLESINDSVSLEDLEEIVGDIKRCWDERRANMAGGSGRPLPSQSQNATLSTSKPVHSQPPSNDKEPKYVDEDDWSD
SIO_010081: YGL130W
subclass of: SO_0000673
so part of: YGL130W
location: 266145..267524
location: region:266145-267524:1
so has part: feature:266145-267524:1:exon

NP_011385.3
type: Protein
SIO_000068: ncbiprotein

S000003098
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:266145-267524:1:exon

YGL129C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: mS29
gene: RSM23
locus tag: YGL129C
gene synonym: mS29
so part of: sequence
location: complement(<267723..>269075)
location: region:267723-269075:-1
so has part: feature:267723-269075:-1:exon
subclass of: SO_0000010

852748
type: Gene
SIO_000068: ncbigene

position:267723:-1
position: 267723
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:269075:-1
position: 269075
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:267723-269075:-1:exon

YGL129C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: mS29
gene: RSM23
locus tag: YGL129C
gene synonym: mS29
product: mitochondrial 37S ribosomal protein RSM23
transcript id: NM_001180994.2
SIO_010081: YGL129C
subclass of: SO_0000673
so part of: YGL129C
location: complement(<267723..>269075)
location: region:267723-269075:-1
so has part: feature:267723-269075:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:267723-269075:-1:exon

YGL129C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: mS29
gene: RSM23
locus tag: YGL129C
gene synonym: mS29
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
codon start: 1
product: mitochondrial 37S ribosomal protein RSM23
translation: MLRMSTSRFIGQRLFTTARSLQAAKPAPKGKTQGFSKKSSSVSSYSSAKRVTPGSLYKNWTNTTHTAQLQQTAVPLALPIFNFDDISKTLNKVVSYSNKQYKSLHHLGSFKKSQFNELFQKPVCLVREDATNSFLKKLVSHPVKKFIITGEPGVGKTVLLSQAHAYAVDSKQIIINISYPELFLNGRNDFSYDDDLKLFIQPMYLKKLIRKILKANDPALLKSIELSKDYKFSNANPKNASVKPFVTLNKTKNTVLDLLSVMTHPHNRGKLMKAIIDELSVQSKVPIMFTVDNFSKVLTTAYSAYRNTENKQIYSLDLQMGKLMMDIISGETKFANGESSTILAISGVDRTNKTLPVALGKIPVDPYVTRYHYEPKFVELLQKGNVTEFEVPKLNKQEVNELIDYYKQSNVLLDKDITGKKWENLIDEKYFLSGNGNPRELLKSLVLSHR
SIO_010081: YGL129C
subclass of: SO_0000673
so part of: YGL129C
location: complement(267723..269075)
location: region:267723-269075:-1
so has part: feature:267723-269075:-1:exon

NP_011386.2
type: Protein
SIO_000068: ncbiprotein

S000003097
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:267723-269075:-1:exon

YGL128C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CWC23
locus tag: YGL128C
so part of: sequence
location: complement(<269293..>270144)
location: region:269293-270144:-1
so has part: feature:269293-270144:-1:exon
subclass of: SO_0000010

852749
type: Gene
SIO_000068: ncbigene

position:269293:-1
position: 269293
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270144:-1
position: 270144
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:269293-270144:-1:exon

YGL128C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CWC23
locus tag: YGL128C
product: U2-type spliceosomal complex subunit CWC23
transcript id: NM_001180993.1
SIO_010081: YGL128C
subclass of: SO_0000673
so part of: YGL128C
location: complement(<269293..>270144)
location: region:269293-270144:-1
so has part: feature:269293-270144:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:269293-270144:-1:exon

YGL128C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CWC23
locus tag: YGL128C
experiment: EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]
experiment: EXISTENCE:genetic interaction:GO:0000390 spliceosomal complex disassembly [PMID:19822657]
note: Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
codon start: 1
product: U2-type spliceosomal complex subunit CWC23
translation: MPGHELEDVINQRLNLYDVLELPTPLDVHTIYDDLPQIKRKYRTLALKYHPDKHPDNPSIIHKFHLLSTATNILTNADVRPHYDRWLIEFLRKTNDIERNKLIQKLEESESSTIPTTTPHPDLLQIQRHGELLRKLKHFNLPYGDWKHLNTQDQENASQHPYYDCSTLRIVLDNFLQSNNKSNCLSHLRNQVFITLSANEIYDIYFSERNNYSKDDSIIIYTVFDTPITAQHVFRNWSSGNLIPTVKDISPLIPLHYYSDFNLETELNDDIARLVSNEPILLD
SIO_010081: YGL128C
subclass of: SO_0000673
so part of: YGL128C
location: complement(269293..270144)
location: region:269293-270144:-1
so has part: feature:269293-270144:-1:exon

NP_011387.2
type: Protein
SIO_000068: ncbiprotein

S000003096
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:269293-270144:-1:exon

YGL127C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MED31
gene: SOH1
locus tag: YGL127C
gene synonym: MED31
so part of: sequence
location: complement(<270392..>270775)
location: region:270392-270775:-1
so has part: feature:270392-270775:-1:exon
subclass of: SO_0000010

852750
type: Gene
SIO_000068: ncbigene

position:270392:-1
position: 270392
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270775:-1
position: 270775
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270392-270775:-1:exon

YGL127C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MED31
gene: SOH1
locus tag: YGL127C
gene synonym: MED31
product: mediator complex subunit SOH1
transcript id: NM_001180992.1
SIO_010081: YGL127C
subclass of: SO_0000673
so part of: YGL127C
location: complement(<270392..>270775)
location: region:270392-270775:-1
so has part: feature:270392-270775:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270392-270775:-1:exon

YGL127C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MED31
gene: SOH1
locus tag: YGL127C
gene synonym: MED31
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19057509]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19368889]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:15356001|PMID:15477388]
experiment: EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]
experiment: EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:18069899]
experiment: EXISTENCE:physical interaction:GO:0006281 DNA repair [PMID:8849885]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
codon start: 1
product: mediator complex subunit SOH1
translation: MSSTNGNAPATPSSDQNPLPTRFEVELEFIQSLANIQYVTYLLTQQQIWKSPNFKNYLKYLEYWCNPPYSQCIVYPNCLFILKLLNGFMESAIVNEDGLLEGLDELPKIIQLQGPQWMNEMVERWAN
SIO_010081: YGL127C
subclass of: SO_0000673
so part of: YGL127C
location: complement(270392..270775)
location: region:270392-270775:-1
so has part: feature:270392-270775:-1:exon

NP_011388.1
type: Protein
SIO_000068: ncbiprotein

S000003095
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270392-270775:-1:exon

YGL126W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FIT2B
gene: SCS3
locus tag: YGL126W
gene synonym: FIT2B
so part of: sequence
location: <270997..>272139
location: region:270997-272139:1
so has part: feature:270997-272139:1:exon
subclass of: SO_0000010

852751
type: Gene
SIO_000068: ncbigene

position:270997:1
position: 270997
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:272139:1
position: 272139
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270997-272139:1:exon

YGL126W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FIT2B
gene: SCS3
locus tag: YGL126W
gene synonym: FIT2B
product: Scs3p
transcript id: NM_001180991.3
SIO_010081: YGL126W
subclass of: SO_0000673
so part of: YGL126W
location: <270997..>272139
location: region:270997-272139:1
so has part: feature:270997-272139:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270997-272139:1:exon

YGL126W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FIT2B
gene: SCS3
locus tag: YGL126W
gene synonym: FIT2B
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:29526591|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:7706223]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:22927826]
experiment: EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:33033181]
note: Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy
codon start: 1
product: Scs3p
translation: MSSKWFNAIHLLVCPLTVLVGYLMNAYGYGAALQATLNKDGLVNAMLVKKGWFWTSLVGWWCIIRYRAVPGATGRDRRHIVQSFKRYAILTVWWYVFTQGIWFGVGPIMDLVFVYTGGHCHYDVFDDAGHVNEDFQGSVTRTNRALALIHNVLTLHGHHQEHRQQQLWDRSIGSIQGALQATQPKTPKNVTASAAAAINTFIHDQMHRWQGPLTTSAQCRRFGGHWAGGHDPSGHVFLATLMCMFLLGELRVFGRRALAHLYAQKWQLVRLVTRLFDTGPLWTWRRCGGGSMTCGARLWRAIVEPPVTCAAALLRLTRCIACDHPVIILLTLLVTWLWQLLLTAVASRFHTVREHMSGLLAAYIVTGLVYARDAAALRPV
SIO_010081: YGL126W
subclass of: SO_0000673
so part of: YGL126W
location: 270997..272139
location: region:270997-272139:1
so has part: feature:270997-272139:1:exon

NP_011389.3
type: Protein
SIO_000068: ncbiprotein

S000003094
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270997-272139:1:exon

YGL125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MET11
alternative label: MRPL45
gene: MET13
locus tag: YGL125W
gene synonym: MET11; MRPL45
so part of: sequence
location: <272520..>274322
location: region:272520-274322:1
so has part: feature:272520-274322:1:exon
subclass of: SO_0000010

852752
type: Gene
SIO_000068: ncbigene

position:272520:1
position: 272520
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:274322:1
position: 274322
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272520-274322:1:exon

YGL125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MET11
alternative label: MRPL45
gene: MET13
locus tag: YGL125W
gene synonym: MET11; MRPL45
product: methylenetetrahydrofolate reductase (NAD(P)H) MET13
transcript id: NM_001180990.1
SIO_010081: YGL125W
subclass of: SO_0000673
so part of: YGL125W
location: <272520..>274322
location: region:272520-274322:1
so has part: feature:272520-274322:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272520-274322:1:exon

YGL125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MET11
alternative label: MRPL45
gene: MET13
locus tag: YGL125W
gene synonym: MET11; MRPL45
EC number: 1.5.1.20
experiment: EXISTENCE:direct assay:GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity [PMID:10600168]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:10600168|PMID:10029993]
note: Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
codon start: 1
product: methylenetetrahydrofolate reductase (NAD(P)H) MET13
translation: MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEFPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTPTSINDVAFLVINYLNGNLKCLPWSDIPINDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQYLEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQPTIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPDDQIHSILLSL
SIO_010081: YGL125W
subclass of: SO_0000673
so part of: YGL125W
location: 272520..274322
location: region:272520-274322:1
so has part: feature:272520-274322:1:exon

NP_011390.2
type: Protein
SIO_000068: ncbiprotein

S000003093
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272520-274322:1:exon

YGL124C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AUT12
gene: MON1
locus tag: YGL124C
gene synonym: AUT12
so part of: sequence
location: complement(<274780..>276714)
location: region:274780-276714:-1
so has part: feature:274780-276714:-1:exon
subclass of: SO_0000010

852753
type: Gene
SIO_000068: ncbigene

position:274780:-1
position: 274780
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276714:-1
position: 276714
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274780-276714:-1:exon

YGL124C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AUT12
gene: MON1
locus tag: YGL124C
gene synonym: AUT12
product: Mon1p
transcript id: NM_001180989.2
SIO_010081: YGL124C
subclass of: SO_0000673
so part of: YGL124C
location: complement(<274780..>276714)
location: region:274780-276714:-1
so has part: feature:274780-276714:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274780-276714:-1:exon

YGL124C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AUT12
gene: MON1
locus tag: YGL124C
gene synonym: AUT12
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12364329]
experiment: EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:24413168]
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:20797862|PMID:24413168]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:20797862]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12387888]
experiment: EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:24413168]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:24413168]
experiment: EXISTENCE:direct assay:GO:0035658 Mon1-Ccz1 complex [PMID:24413168]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:20797862|PMID:24413168]
experiment: EXISTENCE:genetic interaction:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:12387888]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:19793921]
experiment: EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]
experiment: EXISTENCE:mutant phenotype:GO:0048278 vesicle docking [PMID:14662743]
experiment: EXISTENCE:physical interaction:GO:0035658 Mon1-Ccz1 complex [PMID:20797862]
note: Subunit of heterodimeric guanine nucleotide exchange factor (GEF); subunit of Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3 pathway
codon start: 1
product: Mon1p
translation: MNLNESYLDAEIPKGQLKHSKSGNFEGIPIVATTSEPTTSVNLDETFFKKAPIAMPICDDHSVSKSTSVNSLNTTSLASRRSPLQTKKLQAKNNLLSADLAKSNDDTTRALNSPKKDFGPYLDSENDIRSRLAESIYSMETSIRGSELQRRPYVSNEIPNVFKFSKFNSNCKLNESQTLCDKNFFIFTSAGKPIYCMHGKDEQIMSYTGLVNTVISYFQVNGPSELKTISTLTSGKRLTFLDKSPILLMAQSERGESSNELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTDFENLDEICSLICNRMFPDLLLNSLQCLPFNHSSRLKLQNVVLQQLEKRQDIPRGTLLYGLIIAPQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNLDETQELWVPICFPKFNSSGFLYCYIKFLPNDTHSNEKSALVLISAQKDAFFSLKSFSDELIIKLEEEKLLKKINTSKGFKLSDIPAPMVHHFIYKSKQNVQYVMPHFEVNSNIALDSSQGLEYELKLKTYYQQLHGTVVRDNGNLLSRSMLNFVRWSSKDNEDLAMDETQMDFSELDEYIIGNSSFKQESVNMVGMAWVTPTFELYLIGNNGIVDKRVLFKSARKVANWCQKHESRLFISDGAVF
SIO_010081: YGL124C
subclass of: SO_0000673
so part of: YGL124C
location: complement(274780..276714)
location: region:274780-276714:-1
so has part: feature:274780-276714:-1:exon

NP_011391.2
type: Protein
SIO_000068: ncbiprotein

S000003092
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274780-276714:-1:exon

YGL123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS4
alternative label: SUP138
alternative label: SUP38
alternative label: SUP44
gene: RPS2
locus tag: YGL123W
gene synonym: RPS4; SUP138; SUP38; SUP44
so part of: sequence
location: <277617..>278381
location: region:277617-278381:1
so has part: feature:277617-278381:1:exon
subclass of: SO_0000010

852754
type: Gene
SIO_000068: ncbigene

position:277617:1
position: 277617
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:278381:1
position: 278381
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:277617-278381:1:exon

YGL123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS4
alternative label: SUP138
alternative label: SUP38
alternative label: SUP44
gene: RPS2
locus tag: YGL123W
gene synonym: RPS4; SUP138; SUP38; SUP44
product: ribosomal 40S subunit protein S2
transcript id: NM_001180988.1
SIO_010081: YGL123W
subclass of: SO_0000673
so part of: YGL123W
location: <277617..>278381
location: region:277617-278381:1
so has part: feature:277617-278381:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:277617-278381:1:exon

YGL123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS4
alternative label: SUP138
alternative label: SUP38
alternative label: SUP44
gene: RPS2
locus tag: YGL123W
gene synonym: RPS4; SUP138; SUP38; SUP44
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2517480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:2517480|PMID:3533916|PMID:385049]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:2517480]
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:17545469|PMID:3522920]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:31182640]
note: Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; required for release of methyltransferase Bud23p from pre-40S precursor; homologous to mammalian ribosomal protein S2 and bacterial S5
codon start: 1
product: ribosomal 40S subunit protein S2
translation: MSAPEAQQQKRGGFGGRNRGRPNRRGPRNTEEKGWVPVTKLGRLVKAGKITTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNIKPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQPHSLATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLLQLAGVEDVYTQSNGKTRTLENTLKAAFVAIGNTYGFLTPNLWAEQPLPVSPLDIYSDEASAQKKRF
SIO_010081: YGL123W
subclass of: SO_0000673
so part of: YGL123W
location: 277617..278381
location: region:277617-278381:1
so has part: feature:277617-278381:1:exon

NP_011392.1
type: Protein
SIO_000068: ncbiprotein

S000003091
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:277617-278381:1:exon

YGL122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAB2
locus tag: YGL122C
so part of: sequence
location: complement(<278946..>280523)
location: region:278946-280523:-1
so has part: feature:278946-280523:-1:exon
subclass of: SO_0000010

852755
type: Gene
SIO_000068: ncbigene

position:278946:-1
position: 278946
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280523:-1
position: 280523
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278946-280523:-1:exon

YGL122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAB2
locus tag: YGL122C
product: mRNA-binding protein NAB2
transcript id: NM_001180987.3
SIO_010081: YGL122C
subclass of: SO_0000673
so part of: YGL122C
location: complement(<278946..>280523)
location: region:278946-280523:-1
so has part: feature:278946-280523:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278946-280523:-1:exon

YGL122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAB2
locus tag: YGL122C
experiment: EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:26220998]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7962083|PMID:11779864|PMID:8474438]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7962083]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11927564]
experiment: EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:26220998]
experiment: EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:17630287]
experiment: EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:26220998]
experiment: EXISTENCE:direct assay:GO:0033204 ribonuclease P RNA binding [PMID:26220998]
experiment: EXISTENCE:direct assay:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:26220998]
experiment: EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:26119729]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:11779864]
experiment: EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:17636033]
experiment: EXISTENCE:physical interaction:GO:0043488 regulation of mRNA stability [PMID:17636033]
note: Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; dimerizes upon RNA binding; protects mRNA against decay by nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs
codon start: 1
product: mRNA-binding protein NAB2
translation: MSQEQYTENLKVIVAEKLAGIPNFNEDIKYVAEYIVLLIVNGGTVESVVDELASLFDSVSRDTLANVVQTAFFALEALQQGESAENIVSKIRMMNAQSLGQSDIAQQQQQQQQQQQPDIAQQQPQQQPQQQPQQQPQQQPQQQPQQQPQQQPQQQPQLQPLQPQLGTQNAMQTDAPATPSPISAFSGVVNAAAPPQFAPVDNSQRFTQRGGGAVGKNRRGGRGGNRGGRNNNSTRFNPLAKALGMAGESNMNFTPTKKEGRCRLFPHCPLGRSCPHAHPTKVCNEYPNCPKPPGTCEFLHPNEDEELMKEMERTREEFQKRKADLLAAKRKPVQTGIVLCKFGALCSNPSCPFGHPTPANEDAKVIDLMWCDKNLTCDNPECRKAHSSLSKIKEVKPISQKKAAPPPVEKSLEQCKFGTHCTNKRCKYRHARSHIMCREGANCTRIDCLFGHPINEDCRFGVNCKNIYCLFRHPPGRVLPEKKGAAPNSNVPTNERPFALPENAIIENAPPQTSFTHQEQDTEMN
SIO_010081: YGL122C
subclass of: SO_0000673
so part of: YGL122C
location: complement(278946..280523)
location: region:278946-280523:-1
so has part: feature:278946-280523:-1:exon

NP_011393.3
type: Protein
SIO_000068: ncbiprotein

S000003090
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278946-280523:-1:exon

YGL121C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GPG1
locus tag: YGL121C
so part of: sequence
location: complement(<280777..>281157)
location: region:280777-281157:-1
so has part: feature:280777-281157:-1:exon
subclass of: SO_0000010

852756
type: Gene
SIO_000068: ncbigene

position:280777:-1
position: 280777
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:281157:-1
position: 281157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:280777-281157:-1:exon

YGL121C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GPG1
locus tag: YGL121C
product: Gpg1p
transcript id: NM_001180986.1
SIO_010081: YGL121C
subclass of: SO_0000673
so part of: YGL121C
location: complement(<280777..>281157)
location: region:280777-281157:-1
so has part: feature:280777-281157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:280777-281157:-1:exon

YGL121C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GPG1
locus tag: YGL121C
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]
experiment: EXISTENCE:mutant phenotype:GO:1905907 negative regulation of amyloid fibril formation [PMID:19129493]
note: Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
codon start: 1
product: Gpg1p
translation: MFYLSDIEEEASAGAEPTYNFWEVLLFSNTQENLVTVVGELHTLTDRVVHYKIEPESREVTATTLPSLLALLLEKRNQARRLYRDVLSMKMSELDWDIDDLFTQLQEELTRTDDTLSMYPRRRFYH
SIO_010081: YGL121C
subclass of: SO_0000673
so part of: YGL121C
location: complement(280777..281157)
location: region:280777-281157:-1
so has part: feature:280777-281157:-1:exon

NP_011394.1
type: Protein
SIO_000068: ncbiprotein

S000003089
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:280777-281157:-1:exon

YGL120C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP43
locus tag: YGL120C
so part of: sequence
location: complement(<281634..>283937)
location: region:281634-283937:-1
so has part: feature:281634-283937:-1:exon
subclass of: SO_0000010

852757
type: Gene
SIO_000068: ncbigene

position:281634:-1
position: 281634
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:283937:-1
position: 283937
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281634-283937:-1:exon

YGL120C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP43
locus tag: YGL120C
product: DEAH-box ATP-dependent RNA helicase PRP43
transcript id: NM_001180985.1
SIO_010081: YGL120C
subclass of: SO_0000673
so part of: YGL120C
location: complement(<281634..>283937)
location: region:281634-283937:-1
so has part: feature:281634-283937:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281634-283937:-1:exon

YGL120C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP43
locus tag: YGL120C
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16357217]
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:17875666]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:genetic interaction:GO:0000390 spliceosomal complex disassembly [PMID:17875666]
experiment: EXISTENCE:genetic interaction:GO:0030490 maturation of SSU-rRNA [PMID:19801658]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]
experiment: EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:11886864]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16227579|PMID:16382144]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:16382143]
experiment: EXISTENCE:mutant phenotype:GO:0071014 post-mRNA release spliceosomal complex [PMID:11886864]
note: RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p
codon start: 1
product: DEAH-box ATP-dependent RNA helicase PRP43
translation: MGSKRRFSSEHPDPVETSIPEQAAEIAEELSKQHPLPSEEPLVHHDAGEFKGLQRHHTSAEEAQKLEDGKINPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKRADDAKNIFAHPDGDHITLLNVYHAFKSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVLGHDAEWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAPAYYDLSNFQKGDVKLSLERIKEKVDRLNELKQGKNKKKSKHSKK
SIO_010081: YGL120C
subclass of: SO_0000673
so part of: YGL120C
location: complement(281634..283937)
location: region:281634-283937:-1
so has part: feature:281634-283937:-1:exon

NP_011395.1
type: Protein
SIO_000068: ncbiprotein

S000003088
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281634-283937:-1:exon

YGL119W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ABC1
gene: COQ8
locus tag: YGL119W
gene synonym: ABC1
so part of: sequence
location: <284442..>285947
location: region:284442-285947:1
so has part: feature:284442-285947:1:exon
subclass of: SO_0000010

852758
type: Gene
SIO_000068: ncbigene

position:284442:1
position: 284442
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:285947:1
position: 285947
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:284442-285947:1:exon

YGL119W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ABC1
gene: COQ8
locus tag: YGL119W
gene synonym: ABC1
product: protein kinase COQ8
transcript id: NM_001180984.1
SIO_010081: YGL119W
subclass of: SO_0000673
so part of: YGL119W
location: <284442..>285947
location: region:284442-285947:1
so has part: feature:284442-285947:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:284442-285947:1:exon

YGL119W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ABC1
gene: COQ8
locus tag: YGL119W
gene synonym: ABC1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11279158|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18801050]
experiment: EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:27499294]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:27499294]
experiment: EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:22593570]
experiment: EXISTENCE:mutant phenotype:GO:0008289 lipid binding [PMID:27499294]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:27499294]
experiment: EXISTENCE:mutant phenotype:GO:1901006 ubiquinone-6 biosynthetic process [PMID:11279158|PMID:25498144]
note: ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2
codon start: 1
product: protein kinase COQ8
translation: MVTNMVKLRNLRRLYCSSRLLRTIQNGRISSVSSISLSKKYTTKSAKEGEENVERKHEEEKKDTLKSSSVPTSRISRLFHYGSLAAGVGMNAAAKGISEVAKGNSPTWKSLILSDSNIDRITNKFSKMRGVALKIGQLLSFQDEKVLPKELYEILSRVQNSANHMPQRQLEKVMAKELGANWKTKFSKFDKIPMAAASIGQVHAAELPSGQRVVVKIQYPGVKESIDSDLNSLLMLLTASSLLPKGLFLDKTIANARTELKWECDYNREARALQKFEALLKDDPAFEVPHVFPEYTTDNIITMTRMEGTEIMKLPKASQETKNFISENIMRLCLEEIATFKYMQTDPNWANFLYNGRTKKIELLDFGASRPFAEDFILKYRKLLTYATLRDRKGAYEMSVQLGYLTGLESQSMKDAHVDSVLTLGEPFRGDVDKSFDFKDQTVSDRIRGNIGLMLNERLCPPPEETYSLHRKFSGIFLLCARMGASVHCAKLFKEIFAYKV
SIO_010081: YGL119W
subclass of: SO_0000673
so part of: YGL119W
location: 284442..285947
location: region:284442-285947:1
so has part: feature:284442-285947:1:exon

NP_011396.1
type: Protein
SIO_000068: ncbiprotein

S000003087
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:284442-285947:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS714; Autonomously Replicating Sequence
so part of: sequence
location: 285991..286081
location: region:285991-286081:1
so has part: feature:285991-286081:1:region

S000118455
type: SGD
SIO_000068: sgd

position:285991:1
position: 285991
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:286081:1
position: 286081
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285991-286081:1:region

YNCG0009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0009C
so part of: sequence
location: complement(287350..287455)
location: region:287350-287455:-1
so has part: feature:287350-287455:-1:exon
subclass of: SO_0000663

852759
type: Gene
SIO_000068: ncbigene

position:287350:-1
position: 287350
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:287455:-1
position: 287455
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287350-287455:-1:exon

YNCG0009C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0009C
product: tRNA-Trp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Tryptophan tRNA (tRNA-Trp), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0009C
subclass of: SO_0000673
so part of: YNCG0009C
location: complement(join(287350..287385,287420..287455))
location: region:287350-287455:-1
so has part: feature:287420-287455:-1:exon
so has part: feature:287350-287385:-1:exon

S000006771
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:287420-287455:-1:exon

position:287420:-1
position: 287420
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:287350-287385:-1:exon

position:287385:-1
position: 287385
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL118C
so part of: sequence
location: complement(<288014..>288451)
location: region:288014-288451:-1
so has part: feature:288014-288451:-1:exon
subclass of: SO_0000010

852760
type: Gene
SIO_000068: ncbigene

position:288014:-1
position: 288014
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:288451:-1
position: 288451
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288014-288451:-1:exon

YGL118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL118C
product: uncharacterized protein
transcript id: NM_001348835.1
SIO_010081: YGL118C
subclass of: SO_0000673
so part of: YGL118C
location: complement(<288014..>288451)
location: region:288014-288451:-1
so has part: feature:288014-288451:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288014-288451:-1:exon

YGL118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL118C
note: hypothetical protein; conserved among S. cerevisiae strains; YGL118C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MPPEPVWHISAVTEKFPTHGAILYISLTFSFYKKMLRVLWHILLVYGKHAGKRKYRKVMTETNDSLYMKRNNCSGEYATLALSTRSCSFNMQQNDWVTMEGLFPFVMVLCHLETKPMKIGIQLILQVPFMGLGIHKENKEFYLIL
SIO_010081: YGL118C
subclass of: SO_0000673
so part of: YGL118C
location: complement(288014..288451)
location: region:288014-288451:-1
so has part: feature:288014-288451:-1:exon

NP_001335776.1
type: Protein
SIO_000068: ncbiprotein

S000003086
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288014-288451:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS715; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 288451..288512
location: region:288451-288512:1
so has part: feature:288451-288512:1:region

S000130165
type: SGD
SIO_000068: sgd

position:288451:1
position: 288451
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:288512:1
position: 288512
reference: sequence
type: ForwardStrandPosition
type: ExactPosition
type: FuzzyPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288451-288512:1:region

YGL117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL117W
so part of: sequence
location: <288512..>289309
location: region:288512-289309:1
so has part: feature:288512-289309:1:exon
subclass of: SO_0000010

852761
type: Gene
SIO_000068: ncbigene

position:289309:1
position: 289309
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288512-289309:1:exon

YGL117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL117W
product: uncharacterized protein
transcript id: NM_001180982.3
SIO_010081: YGL117W
subclass of: SO_0000673
so part of: YGL117W
location: <288512..>289309
location: region:288512-289309:1
so has part: feature:288512-289309:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:288512-289309:1:exon

YGL117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL117W
codon start: 1
product: uncharacterized protein
translation: MQPISIKDVESDQGKVYIVNALKDLVCKCLLEFVDIQIESFMYPDDPKCFTRIFKGNKIVNEASDKDSKVRSYPSSLGVGHSALFPLIYIRQKTNSLRFLNDPKQLPTPLVDDMNAKFKGIIKVYENLIHLYHSYQTVDCNNMNQQKLLGDLVSRGNFMLDILHGYVTIASTIVRDSKDANILIDTVNRFIHDTILFHKRIIHNSNAYTEYHVMKRGMQRNQSEETLVELEFRILDVSDVNLDNEFDDFLQHRKTSLKITHRRVI
SIO_010081: YGL117W
subclass of: SO_0000673
so part of: YGL117W
location: 288512..289309
location: region:288512-289309:1
so has part: feature:288512-289309:1:exon

NP_011398.3
type: Protein
SIO_000068: ncbiprotein

S000003085
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288512-289309:1:exon

YGL116W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAC5
gene: CDC20
locus tag: YGL116W
gene synonym: PAC5
so part of: sequence
location: <289809..>291641
location: region:289809-291641:1
so has part: feature:289809-291641:1:exon
subclass of: SO_0000010

852762
type: Gene
SIO_000068: ncbigene

position:289809:1
position: 289809
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:291641:1
position: 291641
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:289809-291641:1:exon

YGL116W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAC5
gene: CDC20
locus tag: YGL116W
gene synonym: PAC5
product: ubiquitin-protein transferase activating protein CDC20
transcript id: NM_001180981.1
SIO_010081: YGL116W
subclass of: SO_0000673
so part of: YGL116W
location: <289809..>291641
location: region:289809-291641:1
so has part: feature:289809-291641:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:289809-291641:1:exon

YGL116W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAC5
gene: CDC20
locus tag: YGL116W
gene synonym: PAC5
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0010997 anaphase-promoting complex binding [PMID:15916961]
experiment: EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]
experiment: EXISTENCE:direct assay:GO:1904668 positive regulation of ubiquitin protein ligase activity [PMID:15060174|PMID:17889668]
experiment: EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:19362536|PMID:15060174]
experiment: EXISTENCE:genetic interaction:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]
experiment: EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:12152084]
experiment: EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10855492]
experiment: EXISTENCE:mutant phenotype:GO:0045842 positive regulation of mitotic metaphase/anaphase transition [PMID:10647015]
experiment: EXISTENCE:mutant phenotype:GO:1904668 positive regulation of ubiquitin protein ligase activity [PMID:9504909]
experiment: EXISTENCE:mutant phenotype:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]
experiment: EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:9501986]
experiment: EXISTENCE:physical interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:9461437]
experiment: EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]
note: Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: ubiquitin-protein transferase activating protein CDC20
translation: MPESSRDKGNAAISGNRSVLSIASPTKLNILSSDWSRNQGKVSKNSLKRSSSLNIRNSKRPSLQASANSIYSRPKITIGAPPLIRRDSSFFKDEFDAKKDKATFSAYSSRSYPTIGSESVVSQTSLSQPTTSREVDEQFTVAADRYIPILQGASQNKVDPETLHEALPPPNASPISHLRAQTKIVFKQNVAEACGLDMNKRILQYMPEPPKCSSLRQKSYIMKKRTHYSYQQEQKIPDLIKLRKINTNPERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDFENTTICSVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMRSGLGVRIGSLSWLDTLIATGSRSGEIQINDVRIKQHIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTSLPQFSKKTHTAAVKALSWCPYSPNILASGGGQTDKHIHFWNSITGARVGSINTGSQVSSLHWGQSHTSTNGGMMNKEIVATGGNPENAISVYNYETKFKVAEVVHAHEARICCSQLSPDGTTLATVGGDENLKFYKIFDPRCTGRSREDGLMDGMLGLIGKEGCRTNDKENRSKNSSEIHTRRPSSTSQYLIR
SIO_010081: YGL116W
subclass of: SO_0000673
so part of: YGL116W
location: 289809..291641
location: region:289809-291641:1
so has part: feature:289809-291641:1:exon

NP_011399.1
type: Protein
SIO_000068: ncbiprotein

S000003084
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:289809-291641:1:exon

YGL115W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CAT3
alternative label: SCI1
gene: SNF4
locus tag: YGL115W
gene synonym: CAT3; SCI1
so part of: sequence
location: <292033..>293001
location: region:292033-293001:1
so has part: feature:292033-293001:1:exon
subclass of: SO_0000010

852763
type: Gene
SIO_000068: ncbigene

position:292033:1
position: 292033
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:293001:1
position: 293001
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292033-293001:1:exon

YGL115W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CAT3
alternative label: SCI1
gene: SNF4
locus tag: YGL115W
gene synonym: CAT3; SCI1
product: AMP-activated serine/threonine-protein kinase regulatory subunit SNF4
transcript id: NM_001180980.1
SIO_010081: YGL115W
subclass of: SO_0000673
so part of: YGL115W
location: <292033..>293001
location: region:292033-293001:1
so has part: feature:292033-293001:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292033-293001:1:exon

YGL115W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CAT3
alternative label: SCI1
gene: SNF4
locus tag: YGL115W
gene synonym: CAT3; SCI1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17237508|PMID:2481228]
experiment: EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508|PMID:2481228]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562756]
experiment: EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914|PMID:2481228]
experiment: EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:2557546]
experiment: EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:2557546]
experiment: EXISTENCE:genetic interaction:GO:0043539 protein serine/threonine kinase activator activity [PMID:2557546]
experiment: EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:11486005|PMID:2557546|PMID:7913470]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:1355328]
experiment: EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:11486005|PMID:2557546]
experiment: EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:2481228]
experiment: EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:2481228|PMID:9121458]
experiment: EXISTENCE:physical interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:2481228]
note: Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress
codon start: 1
product: AMP-activated serine/threonine-protein kinase regulatory subunit SNF4
translation: MKPTQDSQEKVSIEQQLAVESIRKFLNSKTSYDVLPVSYRLIVLDTSLLVKKSLNVLLQNSIVSAPLWDSKTSRFAGLLTTTDFINVIQYYFSNPDKFELVDKLQLDGLKDIERALGVDQLDTASIHPSRPLFEACLKMLESRSGRIPLIDQDEETHREIVVSVLTQYRILKFVALNCRETHFLKIPIGDLNIITQDNMKSCQMTTPVIDVIQMLTQGRVSSVPIIDENGYLINVYEAYDVLGLIKGGIYNDLSLSVGEALMRRSDDFEGVYTCTKNDKLSTIMDNIRKARVHRFFVVDDVGRLVGVLTLSDILKYILLGSN
SIO_010081: YGL115W
subclass of: SO_0000673
so part of: YGL115W
location: 292033..293001
location: region:292033-293001:1
so has part: feature:292033-293001:1:exon

NP_011400.1
type: Protein
SIO_000068: ncbiprotein

S000003083
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292033-293001:1:exon

YGL114W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL114W
so part of: sequence
location: <293460..>295637
location: region:293460-295637:1
so has part: feature:293460-295637:1:exon
subclass of: SO_0000010

852764
type: Gene
SIO_000068: ncbigene

position:293460:1
position: 293460
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:295637:1
position: 295637
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:293460-295637:1:exon

YGL114W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL114W
product: uncharacterized protein
transcript id: NM_001180979.1
SIO_010081: YGL114W
subclass of: SO_0000673
so part of: YGL114W
location: <293460..>295637
location: region:293460-295637:1
so has part: feature:293460-295637:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:293460-295637:1:exon

YGL114W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL114W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]
note: hypothetical protein; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
codon start: 1
product: uncharacterized protein
translation: MPQSTPSQEVQRVPWDNKPALKQITLRATIAGIAIGSLVLTSNFQFGLQTGWVSMMSLPSALLACAFFKNIWPLIFPNDRPFSDVENVYVQSMAVAVGTGPLAFGFVGVIPAIEKFLTNDESGGLREQGQSFTFRELLIWSTALAFFGIFFAVPLRKQVIVREKLPFPSGSATATLISVLNGTEILQEVSKSELLEMRQRRLNECPEVLQPNRDPEEADYLMNSSHSELGDYTATSQDGSSILSTGSENYRANIIILLKTFVVSSLYTMVSYFVPVIRSIPVFGKYLSNNYLWNFQPSPAYIGQGIIMGLPTVSYMLIGCFLGWGVLAPLARYKRWVPPDADVHDWEEGVQGWILWSSLSIMVADSVVAFIVVTVKSIVKFILIDDKAALLNNIIDDTFQSMLLEEERAINSSRRNTYVDGRQDTVRLVSRDNEIEVDSKHLVRYTTVISGCLVSSIICIVSIIYLFGIQVIPLYAIITALILALFLSILGIRALGETDLNPVSGIGKISQLIFAFIIPRDRPGSVLMNVVSGGIAEASAQQAGDLMQDLKTGHLLGASPRAQFCAQLIGACWSIILSSFMYLCYNKVYSIPSEQFRIPTAVVWIDCARLVTGKGLPDKALECSMILGVIFAVLSLIRNTYRDYGYGWILYIPSGVAVGVGIFNSPSFTIARFIGGWASHFWLKNHRGDLNAKTKMIVFSSGLVLGEGIFSVINMLFICLNVPHY
SIO_010081: YGL114W
subclass of: SO_0000673
so part of: YGL114W
location: 293460..295637
location: region:293460-295637:1
so has part: feature:293460-295637:1:exon

NP_011401.1
type: Protein
SIO_000068: ncbiprotein

S000003082
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:293460-295637:1:exon

YGL113W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLD3
locus tag: YGL113W
so part of: sequence
location: <295932..>297938
location: region:295932-297938:1
so has part: feature:295932-297938:1:exon
subclass of: SO_0000010

852765
type: Gene
SIO_000068: ncbigene

position:295932:1
position: 295932
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:297938:1
position: 297938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:295932-297938:1:exon

YGL113W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLD3
locus tag: YGL113W
product: Sld3p
transcript id: NM_001180978.3
SIO_010081: YGL113W
subclass of: SO_0000673
so part of: YGL113W
location: <295932..>297938
location: region:295932-297938:1
so has part: feature:295932-297938:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:295932-297938:1:exon

YGL113W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLD3
locus tag: YGL113W
experiment: EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11296242]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11296242]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0006268 DNA unwinding involved in DNA replication [PMID:11296242]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:11296242]
experiment: EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:11296242]
note: Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with the DDK-phosphorylated MCM complex and required for the recruitment of Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress; homologous to the human Treslin/Ticrr protein
codon start: 1
product: Sld3p
translation: METWEVIASVKEATKGLDLSLDHPLIIKSEDVPSNILQLLQQKNRRQLKHICMKSRKEYFLLEEYGPGFWVKWPYNYFNGYSLPERRTEVVTTVERERAKRETLKTWDELKFKELLHLWSEEPKGSCKLEKDKDLKLDMNPPDMKGESKINDYYSDPKEYIESKYYDALFSIHTPLAYFVKSNLVRLKNTCRTKYGSDSYKIAYQAMLQKFLLSIVQFKDRHDNRLLLEPFSSPIADEKRKNCLTKFVIQDENKNSSTIADLCVVLKSREIKLQILLLLEIIGLNDLDWNFRDFEKKYKLKLKKRSLNLTKKGLVRRRSKKKTSEKDKGIERITTSLDYCEQLDLYLDRACILDILLSSETPNPDAIEASNGTIQEHKKNILDKSKEASLVGFINYVLIPYFNKKVPHAVEFIIQKLKGPSMRPKRALKKVNDSTNVSSPNTVETYNRLSTSQRASRSSIINSVPSSPALRRVDANLFSRKSIASPTPELLNSRTNSNLNEFLESETRSLKRPSQLGRTKSDLTMNHLQKRQFSVSDLSTTRVPNSSTITLKTPFSHSTINAYKTMNNSFRRVGKRKDINETIRLHERVDSEENVQVQATPAVKKRTVTPNKKAQLQSIIESPLNFKDDDTHEGRKNTSNITSTPTNKPPENSSKRRVRRRLFAPEST
SIO_010081: YGL113W
subclass of: SO_0000673
so part of: YGL113W
location: 295932..297938
location: region:295932-297938:1
so has part: feature:295932-297938:1:exon

NP_011402.3
type: Protein
SIO_000068: ncbiprotein

S000003081
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:295932-297938:1:exon

YGL112C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAF60
gene: TAF6
locus tag: YGL112C
gene synonym: TAF60
so part of: sequence
location: complement(<298178..>299728)
location: region:298178-299728:-1
so has part: feature:298178-299728:-1:exon
subclass of: SO_0000010

852766
type: Gene
SIO_000068: ncbigene

position:298178:-1
position: 298178
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:299728:-1
position: 299728
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298178-299728:-1:exon

YGL112C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAF60
gene: TAF6
locus tag: YGL112C
gene synonym: TAF60
product: TATA-binding protein-associated factor TAF6
transcript id: NM_001180977.1
SIO_010081: YGL112C
subclass of: SO_0000673
so part of: YGL112C
location: complement(<298178..>299728)
location: region:298178-299728:-1
so has part: feature:298178-299728:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298178-299728:-1:exon

YGL112C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAF60
gene: TAF6
locus tag: YGL112C
gene synonym: TAF60
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10817999]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9844639]
experiment: EXISTENCE:mutant phenotype:GO:2000144 positive regulation of DNA-templated transcription initiation [PMID:29485702]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
note: Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: TATA-binding protein-associated factor TAF6
translation: MSTQQQSYTIWSPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVLNVEPLYGYYDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFDRLINEPLPQVPRLPTFTTHWLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTGASQHLSNVKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPYFIQFIAEQITQNLSDLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLGGSPKDDSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRVTRTLLKTFLDINRVFGTYYGCLKGVSVLEGESIRFFLGNLNNWARLVFNESGITLDNIEEHLNDDSNPTRTKFTKEETQILVDTVISALLVLKKDLPDLYEGKGEKVTDEDKEKLLERCGVTIGFHILKRDDAKELISAIFFGE
SIO_010081: YGL112C
subclass of: SO_0000673
so part of: YGL112C
location: complement(298178..299728)
location: region:298178-299728:-1
so has part: feature:298178-299728:-1:exon

NP_011403.1
type: Protein
SIO_000068: ncbiprotein

S000003080
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298178-299728:-1:exon

YGL111W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSA1
locus tag: YGL111W
so part of: sequence
location: <299978..>301369
location: region:299978-301369:1
so has part: feature:299978-301369:1:exon
subclass of: SO_0000010

852767
type: Gene
SIO_000068: ncbigene

position:299978:1
position: 299978
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301369:1
position: 301369
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:299978-301369:1:exon

YGL111W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSA1
locus tag: YGL111W
product: ribosome biosynthesis protein NSA1
transcript id: NM_001180976.1
SIO_010081: YGL111W
subclass of: SO_0000673
so part of: YGL111W
location: <299978..>301369
location: region:299978-301369:1
so has part: feature:299978-301369:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:299978-301369:1:exon

YGL111W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSA1
locus tag: YGL111W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
note: Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis
codon start: 1
product: ribosome biosynthesis protein NSA1
translation: MRLLVSCVDSGSIKEVLCNIGTDTSVQSALQPFHVAPHLAEGLKAYVDRMWVISEDEAILARNSGVVELVKISKHLKENEALQVDPKGESKNEKSLSDDLPKFDISEFEITSSVSDLFDDAKLESLSSKSVKRTKLVDGFVTLCPIKKDSSNNTFVAATKSGLLHIIKKGEDKKLIKLASLGLKAPVEFLQLYDLEDTDTDKYIFAYGGEENLIKLVEIDSSFQSLKQIWEAKNVKNDRLDMRVPVWPMALRFLEPSPGKTEKGKLNYQFAAITRWSHLTKYSTQHGRKPFAQIDLLPNREPLSQMEVFDAKGENVVSSLGNFQSETFNELNVITTDYKKNVFKFDGNGRMLGKVGRDDITGSSTYIHVHDGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFIVMLDDVEIEMPLSPSAKAAKGKQKRKVTELEEDADELWNKLEGKVAASKASKKSKI
SIO_010081: YGL111W
subclass of: SO_0000673
so part of: YGL111W
location: 299978..301369
location: region:299978-301369:1
so has part: feature:299978-301369:1:exon

NP_011404.1
type: Protein
SIO_000068: ncbiprotein

S000003079
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:299978-301369:1:exon

YGL110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RQT3
gene: CUE3
locus tag: YGL110C
gene synonym: RQT3
so part of: sequence
location: complement(<301537..>303411)
location: region:301537-303411:-1
so has part: feature:301537-303411:-1:exon
subclass of: SO_0000010

852768
type: Gene
SIO_000068: ncbigene

position:301537:-1
position: 301537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:303411:-1
position: 303411
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301537-303411:-1:exon

YGL110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RQT3
gene: CUE3
locus tag: YGL110C
gene synonym: RQT3
product: Cue3p
transcript id: NM_001180975.1
SIO_010081: YGL110C
subclass of: SO_0000673
so part of: YGL110C
location: complement(<301537..>303411)
location: region:301537-303411:-1
so has part: feature:301537-303411:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:301537-303411:-1:exon

YGL110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RQT3
gene: CUE3
locus tag: YGL110C
gene synonym: RQT3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]
experiment: EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:28757607]
note: Subunit of ribosome-associated quality control trigger complex (RQT); has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
codon start: 1
product: Cue3p
translation: MLSRYNRVIEINGGNADISLPIVKFPPFKLRAQLIEKDPVVWLHLIETYVTYFEYLMQGANVELLDESTLDHLRLFLRTYLHEIADEEGKLLSLGINHDVSEQLYLLKGWIFSLIKKCGLLHLQIFGDSLWNLIKVYVRRNPDSIRGLIDGSLKPRINTQRVQLDKSYQVQQHLKQLIESGKFKRIDLRCVEDLLSAKSMQPNKFAENFFTANWIEILEALWAKGQGRGHKEARELIIISLFSVSADRLLKITKELGISNFETLALYPLLGTMLINEGVHKRLPDLKSKLLFLNLGGLSMDEGDHMSYPTSSGTEVNEEQLSALMELFPQFSKYQLSQTLLAYDNNIELVTNKIFEDPTIIEAFSREPAEEEVEPVSDGDNASFTEELSILDRGDSSKNKELDKKIISEGVPDELRNKTLTRALKLLYEADEDERDDTYDEADVNRSDPSKRIGLQEDEESYDTKDDSNEVRQDHNYHIVEAYLWNLLKEDPKLFERSKRGTKVRKTMKEMTSWSDEKIEGWCRMLERSPTRARLLEKKFMFKGNSKTGKTSYVHNRDSQNDGNVVKEQAKQKKSENIKKHEPQSTEQKKRQHAKNEKRKGARANHNRKKGHDKKLARAGNNAI
SIO_010081: YGL110C
subclass of: SO_0000673
so part of: YGL110C
location: complement(301537..303411)
location: region:301537-303411:-1
so has part: feature:301537-303411:-1:exon

NP_011405.1
type: Protein
SIO_000068: ncbiprotein

S000003078
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301537-303411:-1:exon

YGL108C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL108C
so part of: sequence
location: complement(<303649..>304071)
location: region:303649-304071:-1
so has part: feature:303649-304071:-1:exon
subclass of: SO_0000010

852770
type: Gene
SIO_000068: ncbigene

position:303649:-1
position: 303649
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:304071:-1
position: 304071
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:303649-304071:-1:exon

YGL108C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL108C
product: uncharacterized protein
transcript id: NM_001180973.3
SIO_010081: YGL108C
subclass of: SO_0000673
so part of: YGL108C
location: complement(<303649..>304071)
location: region:303649-304071:-1
so has part: feature:303649-304071:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:303649-304071:-1:exon

YGL108C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL108C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
note: hypothetical protein, predicted to be palmitoylated; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol, while N-terminal GFP fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MGLCGSKTQPMPSQTTTVATKARTKPINRDTVKSKQELRHKEKKDKKKKTQLKSTTVPVVQRKEGSKLTDTSDPSKNKVSPKEAARLAAEKRFQETNEKYNKGELGKKLAQERAKSHKTRLMEEAEKKHAERERENMIYD
SIO_010081: YGL108C
subclass of: SO_0000673
so part of: YGL108C
location: complement(303649..304071)
location: region:303649-304071:-1
so has part: feature:303649-304071:-1:exon

NP_011407.3
type: Protein
SIO_000068: ncbiprotein

S000003076
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:303649-304071:-1:exon

YGL107C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMD9
locus tag: YGL107C
so part of: sequence
location: complement(<304333..>306273)
location: region:304333-306273:-1
so has part: feature:304333-306273:-1:exon
subclass of: SO_0000010

852771
type: Gene
SIO_000068: ncbigene

position:304333:-1
position: 304333
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:306273:-1
position: 306273
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:304333-306273:-1:exon

YGL107C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMD9
locus tag: YGL107C
product: Rmd9p
transcript id: NM_001180972.1
SIO_010081: YGL107C
subclass of: SO_0000673
so part of: YGL107C
location: complement(<304333..>306273)
location: region:304333-306273:-1
so has part: feature:304333-306273:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:304333-306273:-1:exon

YGL107C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMD9
locus tag: YGL107C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:33876744]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17194786|PMID:14562095|PMID:14576278|PMID:16823961|P MID:24769239]
experiment: EXISTENCE:direct assay:GO:0090615 mitochondrial mRNA processing [PMID:33876744]
experiment: EXISTENCE:direct assay:GO:1903108 regulation of mitochondrial transcription [PMID:33876744]
experiment: EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:17194786]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:17194786|PMID:17194787]
experiment: EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:17194787]
note: Mitochondrial protein that controls mitochondrial gene expression; binds the dodecamer element in mitochondrial mRNAs, facilitates processing and delivery of mitochondrial mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication
codon start: 1
product: Rmd9p
translation: MMLRRNAVRSLKTMEISVSNVVNSGSIAMLRGKLANVVLSDRTYHSSPIFHKNVPKGVLDKKNGREQRKTEQNVFNVDPASPWRHELLSFDECVSSALKYSTTPLQNTYKRIGNNQLNKNPSFAMFWDSMGRAMELYYSLRESPDFNAYRVSRLIHLLHNGLRSTRDQLVKLSRKPDYDSQSFHKEMMNFLCNSLKDISDDILIGKVSVSGYGATHLLTSFKELSFDDDCIRIWEASKNLSDETTSQAFQEPKVVGFMLPLLYAKTRSLTEPNELYNQIIQSKEFIHPNLYSGLIKVFIKAEDYEKALSLFGQLCEKAEVRNYGYLIETHLSFIGDSKNLTLAESFFDKIINDEMPYKIILQVSTVNSFLQNIWKAQNDFDHVYRIWEKAVKFYGNTVNPGILSSLNNTFFTIFFENYINDNINGFRKLQEIITFYSGVKKIDEPFFNVMLTRASIWHERSIIDFIDKNYTLYHIPRTIISYRILLKSLGSIDNTNNEEILDRWLELVKKLNELGQQYIANADLSALRDATVVWSQSKRDEKVFSAKAKGTPATTTTTEDDIKVPKPLENLKNEDSTSNSEDRIELYLKILKRYTPYFRATKQVYRYTTGCAESYPILNEYLSGYSDLSAEDIPVPQLHSFIAKEQ
SIO_010081: YGL107C
subclass of: SO_0000673
so part of: YGL107C
location: complement(304333..306273)
location: region:304333-306273:-1
so has part: feature:304333-306273:-1:exon

NP_011408.1
type: Protein
SIO_000068: ncbiprotein

S000003075
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:304333-306273:-1:exon

YGL106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MLC1
locus tag: YGL106W
so part of: sequence
location: <306560..>307009
location: region:306560-307009:1
so has part: feature:306560-307009:1:exon
subclass of: SO_0000010

852772
type: Gene
SIO_000068: ncbigene

position:306560:1
position: 306560
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:307009:1
position: 307009
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:306560-307009:1:exon

YGL106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MLC1
locus tag: YGL106W
product: Mlc1p
transcript id: NM_001180971.1
SIO_010081: YGL106W
subclass of: SO_0000673
so part of: YGL106W
location: <306560..>307009
location: region:306560-307009:1
so has part: feature:306560-307009:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:306560-307009:1:exon

YGL106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MLC1
locus tag: YGL106W
experiment: EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:11082046]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15210731]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15210731|PMID:10873803]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:10873803]
experiment: EXISTENCE:direct assay:GO:0031489 myosin V binding [PMID:9700160]
experiment: EXISTENCE:direct assay:GO:0031982 vesicle [PMID:12456647]
experiment: EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]
experiment: EXISTENCE:genetic interaction:GO:1903476 protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:10873803]
experiment: EXISTENCE:mutant phenotype:GO:0006903 vesicle targeting [PMID:12456647]
experiment: EXISTENCE:mutant phenotype:GO:1903476 protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:10873803|PMID:11082046]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10873803|PMID:11082046|PMID:15210731]
experiment: EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]
experiment: EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:15210731|PMID:11082046]
experiment: EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24413167|PMID:24895401]
note: Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
codon start: 1
product: Mlc1p
translation: MSATRANKDIFTLFDKKGQGAIAKDSLGDYLRAIGYNPTNQLVQDIINADSSLRDASSLTLDQITGLIEVNEKELDATTKAKTEDFVKAFQVFDKESTGKVSVGDLRYMLTGLGEKLTDAEVDELLKGVEVDSNGEIDYKKFIEDVLRQ
SIO_010081: YGL106W
subclass of: SO_0000673
so part of: YGL106W
location: 306560..307009
location: region:306560-307009:1
so has part: feature:306560-307009:1:exon

NP_011409.1
type: Protein
SIO_000068: ncbiprotein

S000003074
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:306560-307009:1:exon

YGL105W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARC1
locus tag: YGL105W
so part of: sequence
location: <307437..>308567
location: region:307437-308567:1
so has part: feature:307437-308567:1:exon
subclass of: SO_0000010

852773
type: Gene
SIO_000068: ncbigene

position:307437:1
position: 307437
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:308567:1
position: 308567
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307437-308567:1:exon

YGL105W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARC1
locus tag: YGL105W
product: Arc1p
transcript id: NM_001180970.1
SIO_010081: YGL105W
subclass of: SO_0000673
so part of: YGL105W
location: <307437..>308567
location: region:307437-308567:1
so has part: feature:307437-308567:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307437-308567:1:exon

YGL105W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARC1
locus tag: YGL105W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11726524|PMID:15710377]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:11069915]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:26359986]
experiment: EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]
experiment: EXISTENCE:direct assay:GO:0051351 positive regulation of ligase activity [PMID:11069915]
experiment: EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16343487]
experiment: EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:11726524]
experiment: EXISTENCE:mutant phenotype:GO:0006418 tRNA aminoacylation for protein translation [PMID:9659920]
experiment: EXISTENCE:mutant phenotype:GO:0017102 methionyl glutamyl tRNA synthetase complex [PMID:9659920]
note: Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p
codon start: 1
product: Arc1p
translation: MSDLVTKFESLIISKYPVSFTKEQSAQAAQWESVLKSGQIQPHLDQLNLVLRDNTFIVSTLYPTSTDVHVFEVALPLIKDLVASSKDVKSTYTTYRHILRWIDYMQNLLEVSSTDKLEINHDLDLPHEVIEKKKKAPAGGAADAAAKADEDVSKKAKKQDHPRGKPDEETLKKLREEAKAKKAAKKAANAKQQQEQQNKAPEKPKPSAIDFRVGFIQKAIKHPDADSLYVSTIDVGDEEGPRTVCSGLVKHFPLDAMQERYVVVVCNLKPVNMRGIKSTAMVLCGSNDDKVEFVEPPKDSKAGDKVFFEGFGDEAPMKQLNPKKKIWEHLQPHFTTNDGLEVIFKDEEEKDHPVRKLTNAKGESFKVASIANAQVR
SIO_010081: YGL105W
subclass of: SO_0000673
so part of: YGL105W
location: 307437..308567
location: region:307437-308567:1
so has part: feature:307437-308567:1:exon

NP_011410.1
type: Protein
SIO_000068: ncbiprotein

S000003073
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307437-308567:1:exon

YGL104C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VPS73
locus tag: YGL104C
so part of: sequence
location: complement(<308713..>310173)
location: region:308713-310173:-1
so has part: feature:308713-310173:-1:exon
subclass of: SO_0000010

852774
type: Gene
SIO_000068: ncbigene

position:308713:-1
position: 308713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:310173:-1
position: 310173
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:308713-310173:-1:exon

YGL104C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VPS73
locus tag: YGL104C
product: putative sugar transporter
transcript id: NM_001180969.3
SIO_010081: YGL104C
subclass of: SO_0000673
so part of: YGL104C
location: complement(<308713..>310173)
location: region:308713-310173:-1
so has part: feature:308713-310173:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:308713-310173:-1:exon

YGL104C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VPS73
locus tag: YGL104C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]
note: Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication
codon start: 1
product: putative sugar transporter
translation: MNRILSSASLLSNVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGYPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGSLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQGIALPLTDSYRWRWILFGSFLIAVLNFFMWFIVDESPKWLLAHGRVTDAKLSLCKLRGVTFDEAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLFGQQFCGINSIVLYGTKIISQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVSVTAFIMGIAMNHNKMNLLIVFSFIYMGVFTMGLNPLPFIIMREVSKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVPETKRSG
SIO_010081: YGL104C
subclass of: SO_0000673
so part of: YGL104C
location: complement(308713..310173)
location: region:308713-310173:-1
so has part: feature:308713-310173:-1:exon

NP_011411.3
type: Protein
SIO_000068: ncbiprotein

S000003072
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:308713-310173:-1:exon

YGL103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CYH2
gene: RPL28
locus tag: YGL103W
gene synonym: CYH2
so part of: sequence
location: <310967..>311927
location: region:310967-311927:1
so has part: feature:310967-311927:1:exon
subclass of: SO_0000010

852775
type: Gene
SIO_000068: ncbigene

position:310967:1
position: 310967
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:311927:1
position: 311927
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:310967-311927:1:exon

YGL103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CYH2
gene: RPL28
locus tag: YGL103W
gene synonym: CYH2
product: ribosomal 60S subunit protein L28
transcript id: NM_001180968.1
SIO_010081: YGL103W
subclass of: SO_0000673
so part of: YGL103W
location: join(<310967..311015,311527..>311927)
location: region:310967-311927:1
so has part: feature:310967-311015:1:exon
so has part: feature:311527-311927:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:310967-311015:1:exon

position:311015:1
position: 311015
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:311527-311927:1:exon

position:311527:1
position: 311527
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CYH2
gene: RPL28
locus tag: YGL103W
gene synonym: CYH2
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:2104804]
note: Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
codon start: 1
product: ribosomal 60S subunit protein L28
translation: MPSRFTKTRKHRGHVSAGKGRIGKHRKHPGGRGMAGGQHHHRINMDKYHPGYFGKVGMRYFHKQQAHFWKPVLNLDKLWTLIPEDKRDQYLKSASKETAPVIDTLAAGYGKILGKGRIPNVPVIVKARFVSKLAEEKIRAAGGVVELIA
SIO_010081: YGL103W
subclass of: SO_0000673
so part of: YGL103W
location: join(310967..311015,311527..311927)
location: region:310967-311927:1
so has part: feature:310967-311015:1:exon
so has part: feature:311527-311927:1:exon

NP_011412.1
type: Protein
SIO_000068: ncbiprotein

S000003071
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:310967-311015:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:311527-311927:1:exon

YGL101W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YGK1
locus tag: YGL101W
so part of: sequence
location: <312193..>312840
location: region:312193-312840:1
so has part: feature:312193-312840:1:exon
subclass of: SO_0000010

852777
type: Gene
SIO_000068: ncbigene

position:312193:1
position: 312193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:312840:1
position: 312840
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312193-312840:1:exon

YGL101W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YGK1
locus tag: YGL101W
product: 5'-deoxynucleotidase
transcript id: NM_001180966.1
SIO_010081: YGL101W
subclass of: SO_0000673
so part of: YGL101W
location: <312193..>312840
location: region:312193-312840:1
so has part: feature:312193-312840:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:312193-312840:1:exon

YGL101W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YGK1
locus tag: YGL101W
EC number: 3.1.3.89
experiment: EXISTENCE:direct assay:GO:0002953 5'-deoxynucleotidase activity [PMID:29752939]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009159 deoxyribonucleoside monophosphate catabolic process [PMID:29752939]
experiment: EXISTENCE:direct assay:GO:0050484 GMP 5'-nucleotidase activity [PMID:29752939]
note: 5'-deoxynucleotidase; non-essential gene involved in deoxyribonucleoside monophosphate degradation; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication
codon start: 1
product: 5'-deoxynucleotidase
translation: MTAVNIWKPEDNIPREILAILSKPHPNYQLAFLNIIQLLKTQRRTGWVDHGIDPCESISDHMYRMGLTTMLITDKNVDRNKCIRIALVHDFAESLVGDITPNDPMTKEEKHRREFETVKYLCESIIRPCSESASREILDDWLAYEKQTCLEGRYVKDIDKYEMLVQCFEYEQKYNGKKDLKQFLGAINDIKTDEVKKWTQSLLEDRQAFFDSLKE
SIO_010081: YGL101W
subclass of: SO_0000673
so part of: YGL101W
location: 312193..312840
location: region:312193-312840:1
so has part: feature:312193-312840:1:exon

NP_011414.1
type: Protein
SIO_000068: ncbiprotein

S000003069
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:312193-312840:1:exon

YGL100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SEH1
locus tag: YGL100W
so part of: sequence
location: <313234..>314283
location: region:313234-314283:1
so has part: feature:313234-314283:1:exon
subclass of: SO_0000010

852778
type: Gene
SIO_000068: ncbigene

position:313234:1
position: 313234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:314283:1
position: 314283
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:313234-314283:1:exon

YGL100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SEH1
locus tag: YGL100W
product: Seh1p
transcript id: NM_001180965.1
SIO_010081: YGL100W
subclass of: SO_0000673
so part of: YGL100W
location: <313234..>314283
location: region:313234-314283:1
so has part: feature:313234-314283:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:313234-314283:1:exon

YGL100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SEH1
locus tag: YGL100W
experiment: EXISTENCE:curator inference:GO:0006913 nucleocytoplasmic transport [PMID:10684247]
experiment: EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:11823431]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:18046406|PMID:11823431]
experiment: EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:23974112]
note: Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcomplex of the SEA complex that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; human SEH1 homolog
codon start: 1
product: Seh1p
translation: MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ
SIO_010081: YGL100W
subclass of: SO_0000673
so part of: YGL100W
location: 313234..314283
location: region:313234-314283:1
so has part: feature:313234-314283:1:exon

NP_011415.1
type: Protein
SIO_000068: ncbiprotein

S000003068
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:313234-314283:1:exon

YGL099W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KRE35
gene: LSG1
locus tag: YGL099W
gene synonym: KRE35
so part of: sequence
location: <314631..>316553
location: region:314631-316553:1
so has part: feature:314631-316553:1:exon
subclass of: SO_0000010

852779
type: Gene
SIO_000068: ncbigene

position:314631:1
position: 314631
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316553:1
position: 316553
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314631-316553:1:exon

YGL099W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KRE35
gene: LSG1
locus tag: YGL099W
gene synonym: KRE35
product: putative GTPase LSG1
transcript id: NM_001180964.3
SIO_010081: YGL099W
subclass of: SO_0000673
so part of: YGL099W
location: <314631..>316553
location: region:314631-316553:1
so has part: feature:314631-316553:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:314631-316553:1:exon

YGL099W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KRE35
gene: LSG1
locus tag: YGL099W
gene synonym: KRE35
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12773575]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:12773575]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:20670889]
experiment: EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:12773575]
note: Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
codon start: 1
product: putative GTPase LSG1
translation: MPPKEAPKKWKAPKGPKPTHRKNKNKLELGRAIKYARQKENAIEYLPDGEMRFTTDKHEANWVKLRSVTQESALDEFLSTAALADKDFTADRHSNVKIIRMDSGNDSATSQGFSMTNEQRGNLNAKQRALAKDLIVPRRPEWNEGMSKFQLDRQEKEAFLEWRRKLAHLQESNEDLLLTPFERNIEVWKQLWRVVERSDLVVQIVDARNPLLFRSVDLERYVKESDDRKANLLLVNKADLLTKKQRIAWAKYFISKNISFTFYSALRANQLLEKQKEMGEDYREQDFEEADKEGFDADEKVMEKVKILSIDQLEELFLSKAPNEPLLPPLPGQPPLINIGLVGYPNVGKSSTINSLVGAKKVSVSSTPGKTKHFQTIKLSDSVMLCDCPGLVFPNFAYNKGELVCNGVLPIDQLRDYIGPAGLVAERIPKYYIEAIYGIHIQTKSRDEGGNGDIPTAQELLVAYARARGYMTQGYGSADEPRASRYILKDYVNGKLLYVNPPPHLEDDTPYTREECEEFNKDLYVFDRLPDTRKEQVQNAAKAKGIDIVDLARDLNQLTFSAHTGGDTQKEAKSVTHGGKQAALYNAAEDLDRDFFKMNNVEGRLSTPFHKVQNSSAGKRHNKKNKSKNAKSKVFSIENN
SIO_010081: YGL099W
subclass of: SO_0000673
so part of: YGL099W
location: 314631..316553
location: region:314631-316553:1
so has part: feature:314631-316553:1:exon

NP_011416.3
type: Protein
SIO_000068: ncbiprotein

S000003067
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:314631-316553:1:exon

YNCG0010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR82
locus tag: YNCG0010W
so part of: sequence
location: 316788..317055
location: region:316788-317055:1
so has part: feature:316788-317055:1:exon
subclass of: SO_0000578

9164893
type: Gene
SIO_000068: ncbigene

position:316788:1
position: 316788
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:317055:1
position: 317055
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316788-317055:1:exon

YNCG0010W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR82
locus tag: YNCG0010W
product: SNR82
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:15306656]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15306656|PMID:15923376]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:15306656|PMID:15923376]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at positions U1110, U2349, and U2351
transcript id: NR_132178.1
SIO_010081: YNCG0010W
subclass of: SO_0000673
so part of: YNCG0010W
location: 316788..317055
location: region:316788-317055:1
so has part: feature:316788-317055:1:exon

S000028467
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316788-317055:1:exon

YGL098W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SLT1
gene: USE1
locus tag: YGL098W
gene synonym: SLT1
so part of: sequence
location: <317342..>318079
location: region:317342-318079:1
so has part: feature:317342-318079:1:exon
subclass of: SO_0000010

852780
type: Gene
SIO_000068: ncbigene

position:317342:1
position: 317342
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:318079:1
position: 318079
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:317342-318079:1:exon

YGL098W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SLT1
gene: USE1
locus tag: YGL098W
gene synonym: SLT1
product: SNAP receptor USE1
transcript id: NM_001180963.1
SIO_010081: YGL098W
subclass of: SO_0000673
so part of: YGL098W
location: <317342..>318079
location: region:317342-318079:1
so has part: feature:317342-318079:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:317342-318079:1:exon

YGL098W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SLT1
gene: USE1
locus tag: YGL098W
gene synonym: SLT1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:12853481]
experiment: EXISTENCE:direct assay:GO:0098554 cytoplasmic side of endoplasmic reticulum membrane [PMID:12893879]
experiment: EXISTENCE:mutant phenotype:GO:0005484 SNAP receptor activity [PMID:12853481]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12893879|PMID:12853481]
experiment: EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:12853481]
note: Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
codon start: 1
product: SNAP receptor USE1
translation: MAETSNDPFLSYVLSSKQLTNLNRLRRKAVTKQLGSSDDNKVSEEFLRYQHTYQREAFEYLQTKHDAHKIMESQYEQYQSSSKTRRYSIDLDSVDAVDTESQTEYPNEEFIDRNEDSEAVMELRKRLLGKGQNKGLGYETTKSVDRQIEDQDTLQQDLIQDMSKLVGSLKQGAVAFQSALDEDKQVLGAAEIGIQVASQGLMDVSGKLRKYDKSKLSYLFYITVFIFMILGLVFTFIIIQLFPAL
SIO_010081: YGL098W
subclass of: SO_0000673
so part of: YGL098W
location: 317342..318079
location: region:317342-318079:1
so has part: feature:317342-318079:1:exon

NP_011417.1
type: Protein
SIO_000068: ncbiprotein

S000003066
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:317342-318079:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 318697..318860
location: region:318697-318860:1
so has part: feature:318697-318860:1:region

S000006942
type: SGD
SIO_000068: sgd

position:318697:1
position: 318697
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:318860:1
position: 318860
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318697-318860:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(319009..319341)
location: region:319009-319341:-1
so has part: feature:319009-319341:-1:region

S000006936
type: SGD
SIO_000068: sgd

position:319009:-1
position: 319009
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:319341:-1
position: 319341
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319009-319341:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(319423..319762)
location: region:319423-319762:-1
so has part: feature:319423-319762:-1:region

S000006937
type: SGD
SIO_000068: sgd

position:319423:-1
position: 319423
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:319762:-1
position: 319762
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319423-319762:-1:region

YNCG0011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0011W
so part of: sequence
location: 319781..319852
location: region:319781-319852:1
so has part: feature:319781-319852:1:exon
subclass of: SO_0000663

852781
type: Gene
SIO_000068: ncbigene

position:319781:1
position: 319781
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:319852:1
position: 319852
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319781-319852:1:exon

YNCG0011W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0011W
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0011W
subclass of: SO_0000673
so part of: YNCG0011W
location: 319781..319852
location: region:319781-319852:1
so has part: feature:319781-319852:1:exon

S000006596
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:319781-319852:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(320355..320707)
location: region:320355-320707:-1
so has part: feature:320355-320707:-1:region

S000006939
type: SGD
SIO_000068: sgd

position:320355:-1
position: 320355
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:320707:-1
position: 320707
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:320355-320707:-1:region

YGL097W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MTR1
alternative label: PRP20
alternative label: TSM437
gene: SRM1
locus tag: YGL097W
gene synonym: MTR1; PRP20; TSM437
so part of: sequence
location: <321782..>323230
location: region:321782-323230:1
so has part: feature:321782-323230:1:exon
subclass of: SO_0000010

852782
type: Gene
SIO_000068: ncbigene

position:321782:1
position: 321782
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:323230:1
position: 323230
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:321782-323230:1:exon

YGL097W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MTR1
alternative label: PRP20
alternative label: TSM437
gene: SRM1
locus tag: YGL097W
gene synonym: MTR1; PRP20; TSM437
product: Ran guanyl-nucleotide exchange factor
transcript id: NM_001180962.1
SIO_010081: YGL097W
subclass of: SO_0000673
so part of: YGL097W
location: <321782..>323230
location: region:321782-323230:1
so has part: feature:321782-323230:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:321782-323230:1:exon

YGL097W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MTR1
alternative label: PRP20
alternative label: TSM437
gene: SRM1
locus tag: YGL097W
gene synonym: MTR1; PRP20; TSM437
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16365162]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1865879|PMID:11024003|PMID:1666302]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11024003]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:1865879]
experiment: EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:11739405]
experiment: EXISTENCE:mutant phenotype:GO:0006407 rRNA export from nucleus [PMID:11739405]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11024003]
experiment: EXISTENCE:mutant phenotype:GO:0006997 nucleus organization [PMID:8455603]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]
note: Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant
codon start: 1
product: Ran guanyl-nucleotide exchange factor
translation: MVKRTVATNGDASGAHRAKKMSKTHASHIINAQEDYKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQLGRKVMERFRLKTLDPRPFGLRHVKYIASGENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYSCGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGCGGQFSVSGGVKLSDEDAEKRADEMDD
SIO_010081: YGL097W
subclass of: SO_0000673
so part of: YGL097W
location: 321782..323230
location: region:321782-323230:1
so has part: feature:321782-323230:1:exon

NP_011418.1
type: Protein
SIO_000068: ncbiprotein

S000003065
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:321782-323230:1:exon

YGL096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOS8
locus tag: YGL096W
so part of: sequence
location: <325331..>326161
location: region:325331-326161:1
so has part: feature:325331-326161:1:exon
subclass of: SO_0000010

852783
type: Gene
SIO_000068: ncbigene

position:325331:1
position: 325331
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:326161:1
position: 326161
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:325331-326161:1:exon

YGL096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOS8
locus tag: YGL096W
product: Tos8p
transcript id: NM_001180961.1
SIO_010081: YGL096W
subclass of: SO_0000673
so part of: YGL096W
location: <325331..>326161
location: region:325331-326161:1
so has part: feature:325331-326161:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:325331-326161:1:exon

YGL096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOS8
locus tag: YGL096W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12464632]
note: Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
codon start: 1
product: Tos8p
translation: MGTSIVNLNQKIELPPIQVLFESLNRENETKPHFEERRLYQPNPSFVPRTNIAVGSPVNPVPVSSPVFFIGPSPQRSIQNHNAIMTQNIRQYPVIYNNNREVISTGERNYIITVGGPPVTSSQPEYEHISTPNFYQEQRLAQPHPVNESMMIGGYTNPQPISISRGKMLSGNISTNSVRGSNNGYSAKEKKHKAHGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRKIFSGQNDANNFRRKFSSSTNLAKF
SIO_010081: YGL096W
subclass of: SO_0000673
so part of: YGL096W
location: 325331..326161
location: region:325331-326161:1
so has part: feature:325331-326161:1:exon

NP_011419.1
type: Protein
SIO_000068: ncbiprotein

S000003064
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:325331-326161:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 327904..328224
location: region:327904-328224:1
so has part: feature:327904-328224:1:region

S000006943
type: SGD
SIO_000068: sgd

position:327904:1
position: 327904
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:328224:1
position: 328224
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:327904-328224:1:region

YNCG0012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOE1
locus tag: YNCG0012W
so part of: sequence
location: 328583..328654
location: region:328583-328654:1
so has part: feature:328583-328654:1:exon
subclass of: SO_0000663

852784
type: Gene
SIO_000068: ncbigene

position:328583:1
position: 328583
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:328654:1
position: 328654
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328583-328654:1:exon

YNCG0012W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SOE1
locus tag: YNCG0012W
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; can mutate to become a missense suppressor tRNA that inserts glutamate residues at lysine codons; target of K. lactis zymocin
SIO_010081: YNCG0012W
subclass of: SO_0000673
so part of: YNCG0012W
location: 328583..328654
location: region:328583-328654:1
so has part: feature:328583-328654:1:exon

S000006553
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328583-328654:1:exon

YGL095C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: STT10
alternative label: VPL28
gene: VPS45
locus tag: YGL095C
gene synonym: STT10; VPL28
so part of: sequence
location: complement(<328874..>330607)
location: region:328874-330607:-1
so has part: feature:328874-330607:-1:exon
subclass of: SO_0000010

852785
type: Gene
SIO_000068: ncbigene

position:328874:-1
position: 328874
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330607:-1
position: 330607
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328874-330607:-1:exon

YGL095C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: STT10
alternative label: VPL28
gene: VPS45
locus tag: YGL095C
gene synonym: STT10; VPL28
product: Vps45p
transcript id: NM_001180960.3
SIO_010081: YGL095C
subclass of: SO_0000673
so part of: YGL095C
location: complement(<328874..>330607)
location: region:328874-330607:-1
so has part: feature:328874-330607:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:328874-330607:-1:exon

YGL095C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: STT10
alternative label: VPL28
gene: VPS45
locus tag: YGL095C
gene synonym: STT10; VPL28
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:7720726]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9624182]
experiment: EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:9335586]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:7628704]
experiment: EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:7720726]
experiment: EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9650782]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:7628704]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:10545112]
experiment: EXISTENCE:mutant phenotype:GO:0035543 positive regulation of SNARE complex assembly [PMID:11432826]
experiment: EXISTENCE:mutant phenotype:GO:0048210 Golgi vesicle fusion to target membrane [PMID:9650782]
experiment: EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11432826]
experiment: EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:16769821]
experiment: EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]
experiment: EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:11432826]
note: Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; mutation in human VPS45 is associated with congenital neutropenia and primary myelofibrosis of infancy
codon start: 1
product: Vps45p
translation: MNLFDVADFYINKIVTSQSKLSVANVNEHQRIKVLLLDKNTTPTISLCATQSELLKHEIYLVERIENEQREVSRHLRCLVYVKPTEETLQHLLRELRNPRYGEYQIFFSNIVSKSQLERLAESDDLEAVTKVEEIFQDFFILNQDLFSFDLQPREFLSNKLVWSEGGLTKCTNSLVSVLLSLKIKPDIRYEGASKICERLAKEVSYEIGKNERTFFDFPVMDSTPVLLILDRNTDPITPLLQPWTYQSMINEYIGIKRNIVDLSKVPRIDKDLEKVTLSSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDKTQTNSQINSIEDIKNFIEKYPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQNLSAHDANEEDFSDLIKLLQNEAVDKYYKLKLACIYSLNNQTSSDKIRQLVEILSQQLPPEDVNFFHKFKSLFSRQDKMTQSNHDKDDILTELARRFNSRMNSKSNTAENVYMQHIPEISSLLTDLSKNALFRDRFKEIDTQGHRVIGNQQSKDIPQDVILFVIGGVTYEEARLVHDFNGTMNNRMRVVLGGTSILSTKEYMDSIRSAK
SIO_010081: YGL095C
subclass of: SO_0000673
so part of: YGL095C
location: complement(328874..330607)
location: region:328874-330607:-1
so has part: feature:328874-330607:-1:exon

NP_011420.3
type: Protein
SIO_000068: ncbiprotein

S000003063
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328874-330607:-1:exon

YGL094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAN2
locus tag: YGL094C
so part of: sequence
location: complement(<331118..>334465)
location: region:331118-334465:-1
so has part: feature:331118-334465:-1:exon
subclass of: SO_0000010

852786
type: Gene
SIO_000068: ncbigene

position:331118:-1
position: 331118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:334465:-1
position: 334465
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:331118-334465:-1:exon

YGL094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAN2
locus tag: YGL094C
product: poly(A)-specific ribonuclease
transcript id: NM_001180959.1
SIO_010081: YGL094C
subclass of: SO_0000673
so part of: YGL094C
location: complement(<331118..>334465)
location: region:331118-334465:-1
so has part: feature:331118-334465:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:331118-334465:-1:exon

YGL094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAN2
locus tag: YGL094C
EC number: 3.1.13.4
experiment: EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8550599]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031251 PAN complex [PMID:8816488]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:11953437]
experiment: EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8550599]
experiment: EXISTENCE:mutant phenotype:GO:0004535 poly(A)-specific ribonuclease activity [PMID:8550599]
note: Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
codon start: 1
product: poly(A)-specific ribonuclease
translation: MNNWQHFFNNPVDLSEHLKKPYFRFDNRDKEITAISFDEKANLIWSGDSYGCISSYDPTFQLYTRYRGHIGGNSVKDILSHRDGILSISEDSLHFANRRGVTKLNLTSIDIAAFSELNTMCYSPHSLKNNIYCGGDNTNWGIASIDLNRGCLDSLLNYSSKVKLMCSNNKVLSIGRQTGTVDLLDPTSNRTIKSFNAHSASISAMDLRDNTLVTVGKSKRFYNLYADPFVNVYDLRTMRQLPPVSFSKGTTMGSGGADFVQLHPLLPTVMIVASSSGSFDFIDLSNPTLRTQYVHPCQSIKKLCLSPNGDVLGILEADNHLDTWRRSSNNMGMFTNTPEMLAYPDYFNDITSDGPISVDDETYPLSSVGMPYYLDKLLSAWPPVVFKSEGTIPQLTGKSPLPSSGKLKSNLAVISSQNEKLSTQEFPLLRYDRTKYGMRNAIPDYVCLRDIRKQITSGLETSDIQTYTSINKYEVPPAYSRLPLTSGRFGTDNFDFTPFNNTEYSGLDPDVDNHYTNAIIQLYRFIPEMFNFVVGCLKDENFETTLLTDLGYLFDMMERSHGKICSSSNFQASLKSLTDKRQLENGEPQEHLEEYLESLCIRESIEDFNSSESIKRNMPQKFNRFLLSQLIKEEAQTVNHNITLNQCFGLETEIRTECSCDHYDTTVKLLPSLSISGINKTVIKQLNKKSNGQNILPYIEYAMKNVTQKNSICPTCGKTETITQECTVKNLPSVLSLELSLLDTEFSNIRSSKNWLTSEFYGSIIKNKAVLRSTASELKGTSHIFKYELNGYVAKITDNNNETRLVTYVKKYNPKENCFKWLMFNDYLVVEITEEEALKMTYPWKTPEIIIYCDAEELRKPFFSVDTYSINYDILFRDYFANGIRDTARREYKLLTHDEAPKSGTLVAIDAEFVSLQSELCEIDHQGIRSIIRPKRTALARISIIRGEEGELYGVPFVDDYVVNTNHIEDYLTRYSGILPGDLDPEKSTKRLVRRNVVYRKVWLLMQLGCVFVGHGLNNDFKHININVPRNQIRDTAIYFLQGKRYLSLRYLAYVLLGMNIQEGNHDSIEDAHTALILYKKYLHLKEKAIFEKVLNSVYEEGRAHNFKVPETSKG
SIO_010081: YGL094C
subclass of: SO_0000673
so part of: YGL094C
location: complement(331118..334465)
location: region:331118-334465:-1
so has part: feature:331118-334465:-1:exon

NP_011421.1
type: Protein
SIO_000068: ncbiprotein

S000003062
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:331118-334465:-1:exon

YGL093W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC105
locus tag: YGL093W
so part of: sequence
location: <334886..>337639
location: region:334886-337639:1
so has part: feature:334886-337639:1:exon
subclass of: SO_0000010

852787
type: Gene
SIO_000068: ncbigene

position:334886:1
position: 334886
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337639:1
position: 337639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:334886-337639:1:exon

YGL093W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC105
locus tag: YGL093W
product: Spc105p
transcript id: NM_001180958.1
SIO_010081: YGL093W
subclass of: SO_0000673
so part of: YGL093W
location: <334886..>337639
location: region:334886-337639:1
so has part: feature:334886-337639:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:334886-337639:1:exon

YGL093W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC105
locus tag: YGL093W
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19893618|PMID:27170178]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:19893618]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:19893618]
experiment: EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:19893618]
experiment: EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19893618|PMID:24402315]
experiment: EXISTENCE:physical interaction:GO:0034501 protein localization to kinetochore [PMID:24402315]
note: Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation
codon start: 1
product: Spc105p
translation: MNVDERSRIGGREKDAGPGKGILKQNQSSQMTSSFLENPGVRIPTRIITKKEVLDGSNTTSRINTSNLQSMVKRRVSFAPDVTLHSFTFVPEQNNEIKEPRRRKTSTNSPTKISSQEEPLVTSTQIDDARTEEKTAAEEDPDTSGMELTEPIVATPDSNKASQHDPTSMEMTEVFPRSIRQKNPDVEGESIESSQQIDDVEAVREETMELTAIHNVHDYDSISKDTVEGEPIDLTEYESKPYVPNSVSRSTGKSSDYSVERSNDKSDLSKSENKTNSSQPMEITDIFHADPQNPMSLHSDNNINNDGNEMELTQIQTNFDRDNHHIDESPSEKHAFSSNKRRKLDTVSDYAASVTTPVKEAKDTSGEDNDGDLEMMEKMSPITFSDVDNKIGTRSNDVFTIEPGTEDTGMQTATDDEEDGENVDDNGNKIVEKTRLPEIDKEGQSGIALPTQDYTLREFINEVGVGFLDTKLIDDLDKKVNFPLNSFNFVENQRIDNVFSAFYIDIPILEVEAFRCKELWRSINESKDKFKDFEAQIDKSHPPLLLQEYFSSDEKMKQLMRDQLQLVKGYSKLEAAMEWYEWRKKQLNGLELILAENLNTLKREYEKLNEEVEKVNSIRGKIRKLNEAIKEEIRSLKNLPSDSYKPTLMNRIKIEAFKQELMEHSISLSSSNDFTQEMRSLKLAIAKKSNDILTLRSEVASIDKKIEKRKLFTRFDLPKLRDTLKILESLTGVRFLKFSKATLSIAFLQLDDLRVDINLANFKNNPLSSMKVMNDSNNDDMSYHLFTMLLKNVEAEHQDSMLSNLFFAMKKWRPLLKYIKLLKLLFPVKITQTEEEEALLQFKDYDRRNKTAFFYVISLVSFAQGVFSENGQIPMKVHISTQQDYSPSREVLSDRITHKISGVLPSFTKSRIHLEFT
SIO_010081: YGL093W
subclass of: SO_0000673
so part of: YGL093W
location: 334886..337639
location: region:334886-337639:1
so has part: feature:334886-337639:1:exon

NP_011422.1
type: Protein
SIO_000068: ncbiprotein

S000003061
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:334886-337639:1:exon

YGL092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RAT10
gene: NUP145
locus tag: YGL092W
gene synonym: RAT10
so part of: sequence
location: <337906..>341859
location: region:337906-341859:1
so has part: feature:337906-341859:1:exon
subclass of: SO_0000010

852788
type: Gene
SIO_000068: ncbigene

position:337906:1
position: 337906
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:341859:1
position: 341859
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337906-341859:1:exon

YGL092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RAT10
gene: NUP145
locus tag: YGL092W
gene synonym: RAT10
product: nucleocytoplasmic transporter NUP145
transcript id: NM_001180957.1
SIO_010081: YGL092W
subclass of: SO_0000673
so part of: YGL092W
location: <337906..>341859
location: region:337906-341859:1
so has part: feature:337906-341859:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337906-341859:1:exon

YGL092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RAT10
gene: NUP145
locus tag: YGL092W
gene synonym: RAT10
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8044840]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406|PMID:9305650]
experiment: EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]
experiment: EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]
experiment: EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:20647373]
experiment: EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:20647373]
experiment: EXISTENCE:genetic interaction:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8044840|PMID:9001245|PMID:9133678|PMID:9305650]
experiment: EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:10638763|PMID:11862215|PMID:16418532]
experiment: EXISTENCE:mutant phenotype:GO:0046822 regulation of nucleocytoplasmic transport [PMID:23499021]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:9001245|PMID:9133678|PMID:9305650|PMID:8195299]
experiment: EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]
note: Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98
codon start: 1
product: nucleocytoplasmic transporter NUP145
translation: MFNKSVNSGFTFGNQNTSTPTSTPAQPSSSLQFPQKSTGLFGNVNVNANTSTPSPSGGLFNANSNANSISQQPANNSLFGNKPAQPSGGLFGATNNTTSKSAGSLFGNNNATANSTGSTGLFSGSNNIASSTQNGGLFGNSNNNNITSTTQNGGLFGKPTTTPAGAGGLFGNSSSTNSTTGLFGSNNTQSSTGIFGQKPGASTTGGLFGNNGASFPRSGETTGTMSTNPYGINISNVPMAVADMPRSITSSLSDVNGKSDAEPKPIENRRTYSFSSSVSGNAPLPLASQSSLVSRLSTRLKATQKSTSPNEIFSPSYSKPWLNGAGSAPLVDDFFSSKMTSLAPNENSIFPQNGFNFLSSQRADLTELRKLKIDSNRSAAKKLKLLSGTPAITKKHMQDEQDSSENEPIANADSVTNIDRKENRDNNLDNTYLNGKEQSNNLNKQDGENTLQHEKSSSFGYWCSPSPEQLERLSLKQLAAVSNFVIGRRGYGCITFQHDVDLTAFTKSFREELFGKIVIFRSSKTVEVYPDEATKPMIGHGLNVPAIITLENVYPVDKKTKKPMKDTTKFAEFQVFDRKLRSMREMNYISYNPFGGTWTFKVNHFSIWGLVNEEDAEIDEDDLSKQEDGGEQPLRKVRTLAQSKPSDKEVILKTDGTFGTLSGKDDSIVEEKAYEPDLSDADFEGIEASPKLDVSKDWVEQLILAGSSLRSVFATSKEFDGPCQNEIDLLFSECNDEIDNAKLIMKERRFTASYTFAKFSTGSMLLTKDIVGKSGVSIKRLPTELQRKFLFDDVYLDKEIEKVTIEARKSNPYPQISESSLLFKDALDYMEKTSSDYNLWKLSSILFDPVSYPYKTDNDQVKMALLKKERHCRLTSWIVSQIGPEIEEKIRNSSNEIEQIFLYLLLNDVVRASKLAIESKNGHLSVLISYLGSNDPRIRDLAELQLQKWSTGGCSIDKNISKIYKLLSGSPFEGLFSLKELESEFSWLCLLNLTLCYGQIDEYSLESLVQSHLDKFSLPYDDPIGVIFQLYAANENTEKLYKEVRQRTNALDVQFCWYLIQTLRFNGTRVFSKETSDEATFAFAAQLEFAQLHGHSLFVSCFLNDDKAAEDTIKRLVMREITLLRASTNDHILNRLKIPSQLIFNAQALKDRYEGNYLSEVQNLLLGSSYDLAEMAIVTSLGPRLLLSNNPVQNNELKTLREILNEFPDSERDKWSVSINVFEVYLKLVLDNVETQETIDSLISGMKIFYDQYKHCREVAACCNVMSQEIVSKILEKNNPSIGDSKAKLLELPLGQPEKAYLRGEFAQDLMKCTYKI
SIO_010081: YGL092W
subclass of: SO_0000673
so part of: YGL092W
location: 337906..341859
location: region:337906-341859:1
so has part: feature:337906-341859:1:exon

NP_011423.1
type: Protein
SIO_000068: ncbiprotein

S000003060
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337906-341859:1:exon

YGL091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NBP35
locus tag: YGL091C
so part of: sequence
location: complement(<342056..>343042)
location: region:342056-343042:-1
so has part: feature:342056-343042:-1:exon
subclass of: SO_0000010

852789
type: Gene
SIO_000068: ncbigene

position:342056:-1
position: 342056
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343042:-1
position: 343042
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342056-343042:-1:exon

YGL091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NBP35
locus tag: YGL091C
product: Fe-S cluster-binding ATPase
transcript id: NM_001180956.3
SIO_010081: YGL091C
subclass of: SO_0000673
so part of: YGL091C
location: complement(<342056..>343042)
location: region:342056-343042:-1
so has part: feature:342056-343042:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342056-343042:-1:exon

YGL091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NBP35
locus tag: YGL091C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8921898|PMID:15728363]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15728363]
experiment: EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:17401378]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:26195633]
experiment: EXISTENCE:direct assay:GO:0051539 4 iron, 4 sulfur cluster binding [PMID:17401378]
experiment: EXISTENCE:direct assay:GO:1904564 Nbp35-Cfd1 ATPase complex [PMID:26195633]
experiment: EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]
experiment: EXISTENCE:mutant phenotype:GO:0005506 iron ion binding [PMID:15728363]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15728363]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:8921898]
note: Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
codon start: 1
product: Fe-S cluster-binding ATPase
translation: MTEILPHVNDEVLPAEYELNQPEPEHCPGPESDMAGKSDACGGCANKEICESLPKGPDPDIPLITDNLSGIEHKILVLSGKGGVGKSTFAAMLSWALSADEDLQVGAMDLDICGPSLPHMLGCIKETVHESNSGWTPVYVTDNLATMSIQYMLPEDDSAIIWRGSKKNLLIKKFLKDVDWDKLDYLVIDTPPGTSDEHISINKYMRESGIDGALVVTTPQEVALLDVRKEIDFCKKAGINILGLVENMSGFVCPNCKGESQIFKATTGGGEALCKELGIKFLGSVPLDPRIGKSCDMGESFLDNYPDSPASSAVLNVVEALRDAVGDV
SIO_010081: YGL091C
subclass of: SO_0000673
so part of: YGL091C
location: complement(342056..343042)
location: region:342056-343042:-1
so has part: feature:342056-343042:-1:exon

NP_011424.3
type: Protein
SIO_000068: ncbiprotein

S000003059
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342056-343042:-1:exon

YGL090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LIF1
locus tag: YGL090W
so part of: sequence
location: <343319..>344584
location: region:343319-344584:1
so has part: feature:343319-344584:1:exon
subclass of: SO_0000010

852790
type: Gene
SIO_000068: ncbigene

position:343319:1
position: 343319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:344584:1
position: 344584
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:343319-344584:1:exon

YGL090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LIF1
locus tag: YGL090W
product: Lif1p
transcript id: NM_001180955.1
SIO_010081: YGL090W
subclass of: SO_0000673
so part of: YGL090W
location: <343319..>344584
location: region:343319-344584:1
so has part: feature:343319-344584:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:343319-344584:1:exon

YGL090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LIF1
locus tag: YGL090W
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10679327]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10679327]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11740566]
experiment: EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]
experiment: EXISTENCE:physical interaction:GO:0032807 DNA ligase IV complex [PMID:17567543]
note: Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; sumoylated by Siz1p and Nfi1p SUMO ligases on Lys301; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
codon start: 1
product: Lif1p
translation: MSQLTEFISCIPVVNEEQNEEDERGLCKIQIEDGAMLETLDENSLSGLRIEKMLVSEGTGIFSKSSFGINDLRIFTGENIDEESKKYVWYELLKMLTGHKVYIASLDEKVVFTKWTCRMQDDEVWKVVMELESSAIIRKIAELTLHPVKKGEIDLFEMADKLYKDICCVNDSYRNIKESDSSNRNRVEQLARERELLDKLLETRDERTRAMMVTLLNEKKKKIRELHEILRQNNIKLSDDDVLDSALINTEVQKPISELNSPGKRMKRRKTVVEPQNLQKKLKDTSRRRANRKISNQSVIKMEDDDFDDFQFFGLSKRPIITAKDKLSEKYDDITSFGDDTQSISFESDSSSDVQKHLVSLEDNGIQISAGRSDEDYGDISGSESETDASAGEKKSSNHSEQSGNDREPCLQTESETDIET
SIO_010081: YGL090W
subclass of: SO_0000673
so part of: YGL090W
location: 343319..344584
location: region:343319-344584:1
so has part: feature:343319-344584:1:exon

NP_011425.1
type: Protein
SIO_000068: ncbiprotein

S000003058
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:343319-344584:1:exon

YGL089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MF(ALPHA)2
locus tag: YGL089C
so part of: sequence
location: complement(<344791..>345153)
location: region:344791-345153:-1
so has part: feature:344791-345153:-1:exon
subclass of: SO_0000010

852791
type: Gene
SIO_000068: ncbigene

position:344791:-1
position: 344791
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:345153:-1
position: 345153
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:344791-345153:-1:exon

YGL089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MF(ALPHA)2
locus tag: YGL089C
product: Mf(Alpha)2p
transcript id: NM_001180954.1
SIO_010081: YGL089C
subclass of: SO_0000673
so part of: YGL089C
location: complement(<344791..>345153)
location: region:344791-345153:-1
so has part: feature:344791-345153:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:344791-345153:-1:exon

YGL089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MF(ALPHA)2
locus tag: YGL089C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000772 mating pheromone activity [PMID:6306574]
experiment: EXISTENCE:direct assay:GO:1903135 cupric ion binding [PMID:27476515]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3887136]
experiment: EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3887136]
note: Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions
codon start: 1
product: Mf(Alpha)2p
translation: MKFISTFLTFILAAVSVTASSDEDIAQVPAEAIIGYLDFGGDHDIAFLPFSNATASGLLFINTTIAEAAEKEQNTTLAKREAVADAWHWLNLRPGQPMYKREANADAWHWLQLKPGQPMY
SIO_010081: YGL089C
subclass of: SO_0000673
so part of: YGL089C
location: complement(344791..345153)
location: region:344791-345153:-1
so has part: feature:344791-345153:-1:exon

NP_011426.1
type: Protein
SIO_000068: ncbiprotein

S000003057
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:344791-345153:-1:exon

YGL088W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL088W
so part of: sequence
location: <345836..>346201
location: region:345836-346201:1
so has part: feature:345836-346201:1:exon
subclass of: SO_0000010

852792
type: Gene
SIO_000068: ncbigene

position:345836:1
position: 345836
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346201:1
position: 346201
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:345836-346201:1:exon

YGL088W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL088W
product: uncharacterized protein
transcript id: NM_001348836.1
SIO_010081: YGL088W
subclass of: SO_0000673
so part of: YGL088W
location: <345836..>346201
location: region:345836-346201:1
so has part: feature:345836-346201:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:345836-346201:1:exon

YGL088W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL088W
note: hypothetical protein; conserved across S. cerevisiae strains; partially overlaps snR10, a snoRNA required for preRNA processing
codon start: 1
product: uncharacterized protein
translation: MHEVTRTYYFFLFFFLSYKRQINAAFIALFDFPLLFIYFPFLILVLFYNSNANLTAIRNTYSISSRLNPSGAFLTHEECGLVLQYIYYWLGLENKFIDLGCNSLSVVCFLADLRVYLRVPG
SIO_010081: YGL088W
subclass of: SO_0000673
so part of: YGL088W
location: 345836..346201
location: region:345836-346201:1
so has part: feature:345836-346201:1:exon

NP_001335777.1
type: Protein
SIO_000068: ncbiprotein

S000003056
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:345836-346201:1:exon

YNCG0013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR10
locus tag: YNCG0013W
so part of: sequence
location: 345986..346230
location: region:345986-346230:1
so has part: feature:345986-346230:1:exon
subclass of: SO_0000578

9164894
type: Gene
SIO_000068: ncbigene

position:345986:1
position: 345986
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:346230:1
position: 346230
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:345986-346230:1:exon

YNCG0013W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR10
locus tag: YNCG0013W
product: SNR10
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:3327689]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:3327689|PMID:8455623]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:3327689]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:3327689]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9160748]
experiment: EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:3327689]
experiment: EXISTENCE:physical interaction:GO:0005730 nucleolus [PMID:2121740]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376|PMID:9472021]
note: H/ACA box small nucleolar RNA (snoRNA); essential gene required for for preRNA processing, specifically for cleavage at sites A1 and A2; also guides pseudouridylation of large subunit (LSU) rRNA at position U2923
transcript id: NR_132179.1
SIO_010081: YNCG0013W
subclass of: SO_0000673
so part of: YNCG0013W
location: 345986..346230
location: region:345986-346230:1
so has part: feature:345986-346230:1:exon

S000007499
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:345986-346230:1:exon

YGL087C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MMS2
locus tag: YGL087C
so part of: sequence
location: complement(<346406..>346904)
location: region:346406-346904:-1
so has part: feature:346406-346904:-1:exon
subclass of: SO_0000010

852793
type: Gene
SIO_000068: ncbigene

position:346406:-1
position: 346406
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:346904:-1
position: 346904
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:346406-346904:-1:exon

YGL087C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MMS2
locus tag: YGL087C
product: E2 ubiquitin-conjugating protein MMS2
transcript id: NM_001180952.1
SIO_010081: YGL087C
subclass of: SO_0000673
so part of: YGL087C
location: complement(join(<346406..346808,346894..>346904))
location: region:346406-346904:-1
so has part: feature:346894-346904:-1:exon
so has part: feature:346406-346808:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:346894-346904:-1:exon

position:346894:-1
position: 346894
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:346406-346808:-1:exon

position:346808:-1
position: 346808
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL087C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MMS2
locus tag: YGL087C
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:10089880]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:32265276]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10089880]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]
experiment: EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:10089880|PMID:9576943]
experiment: EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:10089880|PMID:9576943]
experiment: EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:32265276]
experiment: EXISTENCE:physical interaction:GO:0000209 protein polyubiquitination [PMID:10089880]
experiment: EXISTENCE:physical interaction:GO:0031371 ubiquitin conjugating enzyme complex [PMID:10089880]
note: Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
codon start: 1
product: E2 ubiquitin-conjugating protein MMS2
translation: MSKVPRNFRLLEELEKGEKGFGPESCSYGLADSDDITMTKWNGTILGPPHSNHENRIYSLSIDCGPNYPDSPPKVTFISKINLPCVNPTTGEVQTDFHTLRDWKRAYTMETLLLDLRKEMATPANKKLRQPKEGETF
SIO_010081: YGL087C
subclass of: SO_0000673
so part of: YGL087C
location: complement(join(346406..346808,346894..346904))
location: region:346406-346904:-1
so has part: feature:346894-346904:-1:exon
so has part: feature:346406-346808:-1:exon

NP_011428.1
type: Protein
SIO_000068: ncbiprotein

S000003055
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:346894-346904:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:346406-346808:-1:exon

YGL086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAD1
locus tag: YGL086W
so part of: sequence
location: <347119..>349368
location: region:347119-349368:1
so has part: feature:347119-349368:1:exon
subclass of: SO_0000010

852794
type: Gene
SIO_000068: ncbigene

position:347119:1
position: 347119
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349368:1
position: 349368
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347119-349368:1:exon

YGL086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAD1
locus tag: YGL086W
product: coiled-coil domain-containing protein MAD1
transcript id: NM_001180951.3
SIO_010081: YGL086W
subclass of: SO_0000673
so part of: YGL086W
location: <347119..>349368
location: region:347119-349368:1
so has part: feature:347119-349368:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:347119-349368:1:exon

YGL086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAD1
locus tag: YGL086W
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19139260|PMID:24402315|PMID:27170178]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7593191]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:12473689]
experiment: EXISTENCE:genetic interaction:GO:0006913 nucleocytoplasmic transport [PMID:12473689]
experiment: EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]
experiment: EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:19139260]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]
experiment: EXISTENCE:mutant phenotype:GO:0090268 activation of mitotic cell cycle spindle assembly checkpoint [PMID:15802513]
experiment: EXISTENCE:mutant phenotype:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]
experiment: EXISTENCE:physical interaction:GO:0006913 nucleocytoplasmic transport [PMID:12473689]
note: Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability
codon start: 1
product: coiled-coil domain-containing protein MAD1
translation: MDVRAALQCFFSALSGRFTGKKLGLEIYSIQYKMSNSGGSSPFLESPGGSPDVGSTNGQSNRQIQALQFKLNTLQNEYEIEKLQLQKQTNILEKKYKATIDELEKALNDTKYLYESNDKLEQELKSLKERSANSMNDKDKCIEELRTTLQNKDLEMETLRQQYDSKLSKVTNQCDHFKLEAESSHSLLMKYEKEIKRQSVDIKDLQHQVMEKDDELSSVKASKMINSHPNYSTEEFNELTEMNKMIQDQVQYTKELELANMQQANELKKLKQSQDTSTFWKLENEKLQNKLSQLHVLESQYENLQLENIDLKSKLTKWEIYNDSDDDDDNNVNNNDNNNNNKNDNNNDNNNDTSNNNNINNNNRTKNNIRNNPEEIIRDWKLTKKECLILTDMNDKLRLDNNNLKLLNDEMALERNQILDLNKNYENNIVNLKRLNHELEQQKSLSFEECRLLREQLDGLYSAQNNALLEVENSETHASNKNVNEDMNNLIDTYKNKTEDLTNELKKLNDQLLSNSNDVETQRKKRKLTSDQIGLNYSQRLNELQLENVSVSRELSKAQTTIQLLQEKLEKLTKLKEKKIRILQLRDGPFIKDQFIKKNKLLLLEKENADLLNELKKNNPAVETVPISVYDSLNFELKQFEQEVFKSNKRFSRLKQVFNNKSLEFIDVVNSLLGFKLEFQQDSRVKIFSCFKPEKYLIADLNENTLKSNLDADIEGWDDLMNLWVEDRGQLPCFLATITLRLWEQRQAK
SIO_010081: YGL086W
subclass of: SO_0000673
so part of: YGL086W
location: 347119..349368
location: region:347119-349368:1
so has part: feature:347119-349368:1:exon

NP_011429.3
type: Protein
SIO_000068: ncbiprotein

S000003054
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:347119-349368:1:exon

YGL085W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LCL3
locus tag: YGL085W
so part of: sequence
location: <349616..>350440
location: region:349616-350440:1
so has part: feature:349616-350440:1:exon
subclass of: SO_0000010

852795
type: Gene
SIO_000068: ncbigene

position:349616:1
position: 349616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:350440:1
position: 350440
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349616-350440:1:exon

YGL085W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LCL3
locus tag: YGL085W
product: Lcl3p
transcript id: NM_001180950.1
SIO_010081: YGL085W
subclass of: SO_0000673
so part of: YGL085W
location: <349616..>350440
location: region:349616-350440:1
so has part: feature:349616-350440:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349616-350440:1:exon

YGL085W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LCL3
locus tag: YGL085W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
note: hypothetical protein; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
codon start: 1
product: Lcl3p
translation: MREGDSNSKKSADVAVLSIILTGSTLTLIYTYKRYLTQFKRTNDIPRRIFRKHWLYGKVTSVGDGDNFHFFHMPGGIRGGWGWLRPVPQMIKNDSTAEKLVGDSRNMRFFNFNWITHGRSTKSKIQKAKSQFLKLNVPYKNRKNLPTIPIRLCGIDAPERAHFGNPAQPFGNEALIWLQNRILGKKVWVKPLSIDQYNRCVARVSYWDWFGGWKDLSLEMLKDGLAVVYEGKVNTEFDDREDKYRYYEFLARSRKKGLWIQNKFETPGEYKKRI
SIO_010081: YGL085W
subclass of: SO_0000673
so part of: YGL085W
location: 349616..350440
location: region:349616-350440:1
so has part: feature:349616-350440:1:exon

NP_011430.1
type: Protein
SIO_000068: ncbiprotein

S000003053
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349616-350440:1:exon

YGL084C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GUP1
locus tag: YGL084C
so part of: sequence
location: complement(<350616..>352298)
location: region:350616-352298:-1
so has part: feature:350616-352298:-1:exon
subclass of: SO_0000010

852796
type: Gene
SIO_000068: ncbigene

position:350616:-1
position: 350616
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:352298:-1
position: 352298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:350616-352298:-1:exon

YGL084C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GUP1
locus tag: YGL084C
product: O-acyltransferase
transcript id: NM_001180949.1
SIO_010081: YGL084C
subclass of: SO_0000673
so part of: YGL084C
location: complement(<350616..>352298)
location: region:350616-352298:-1
so has part: feature:350616-352298:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:350616-352298:-1:exon

YGL084C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GUP1
locus tag: YGL084C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15813700|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15813700]
experiment: EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16597698]
experiment: EXISTENCE:mutant phenotype:GO:0008374 O-acyltransferase activity [PMID:16597698|PMID:18036137]
experiment: EXISTENCE:mutant phenotype:GO:0015793 glycerol transmembrane transport [PMID:10931309]
experiment: EXISTENCE:mutant phenotype:GO:0019563 glycerol catabolic process [PMID:10747858]
note: Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication
codon start: 1
product: O-acyltransferase
translation: MSLISILSPLITSEGLDSRIKPSPKKDASTTTKPSLWKTTEFKFYYIAFLVVVPLMFYAGLQASSPENPNYARYERLLSQGWLFGRKVDNSDSQYRFFRDNFALLSVLMLVHTSIKRIVLYSTNITKLRFDLIFGLIFLVAAHGVNSIRILAHMLILYAIAHVLKNFRRIATISIWIYGISTLFINDNFRAYPFGNICSFLSPLDHWYRGIIPRWDVFFNFTLLRVLSYNLDFLERWENLQKKKSPSYESKEAKSAILLNERARLTAAHPIQDYSLMNYIAYVTYTPLFIAGPIITFNDYVYQSKHTLPSINFKFIFYYAVRFVIALLSMEFILHFLHVVAISKTKAWENDTPFQISMIGLFNLNIIWLKLLIPWRLFRLWALLDGIDTPENMIRCVDNNYSSLAFWRAWHRSYNKWVVRYIYIPLGGSKNRVLTSLAVFSFVAIWHDIELKLLLWGWLIVLFLLPEIFATQIFSHYTDAVWYRHVCAVGAVFNIWVMMIANLFGFCLGSDGTKKLLSDMFCTVSGFKFVILASVSLFIAVQIMFEIREEEKRHGIYLKC
SIO_010081: YGL084C
subclass of: SO_0000673
so part of: YGL084C
location: complement(350616..352298)
location: region:350616-352298:-1
so has part: feature:350616-352298:-1:exon

NP_011431.1
type: Protein
SIO_000068: ncbiprotein

S000003052
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:350616-352298:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS716; Autonomously Replicating Sequence
so part of: sequence
location: 352760..352906
location: region:352760-352906:1
so has part: feature:352760-352906:1:region

S000118456
type: SGD
SIO_000068: sgd

position:352760:1
position: 352760
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:352906:1
position: 352906
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:352760-352906:1:region

YGL083W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCY1
locus tag: YGL083W
so part of: sequence
location: <353058..>355472
location: region:353058-355472:1
so has part: feature:353058-355472:1:exon
subclass of: SO_0000010

852797
type: Gene
SIO_000068: ncbigene

position:353058:1
position: 353058
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:355472:1
position: 355472
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353058-355472:1:exon

YGL083W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCY1
locus tag: YGL083W
product: Scy1p
transcript id: NM_001180948.1
SIO_010081: YGL083W
subclass of: SO_0000673
so part of: YGL083W
location: <353058..>355472
location: region:353058-355472:1
so has part: feature:353058-355472:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:353058-355472:1:exon

YGL083W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCY1
locus tag: YGL083W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
note: Putative kinase; suppressor of GTPase mutant; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport
codon start: 1
product: Scy1p
translation: MMFWSSKTGITSKYSFSSSPTFTAEPWSIYTGRPKSSSSSSPSKVSIFMFDKKQFENYLLHYGIIKSKSGSRDKVLIQEAYEILRNQANNLAKLKHPNILTLIEPLEEHSKNFMFVTEFVTSSLETVFRETDDEEQNFLQGHVKDNIVVQRGILQLVNALDFVHNRASFVHLNIQPRAIFINENSDWKISGLGYLVKIPPGTNTSEYFLPQYDPRVPPFMHLQLNYTAPEIVFENTLTFKNDYFSLGLLIYFLYTGKDLFRSENSTSEYKLEYNKFESKISTMSWDNIFSKVPQKLRHCIPKLINRDIYSRYDNITLILDSEFFQDPLVKTLNFLDDLPTKNNEEKYVFLEGLVNLLPEFPPALLQKKFLPILLELLSQFCAEKVVSDKCVGKSLDLIIKIGSTLSQLSFQEKVYPVLLSDANFPVLLKKATICLIDNLDTLKQKVKRSDFLENILKPLFNYVLHDSESDITVVCQEKLLSQIPLALEVLDFPTVKQFLLPLLSNLFTKTTSLTVKNTCVTCFQIMIEHKSIDSYTCSETVLPLFKSMKTRDPRILSKLLKLFETVPLIITDEIVLVDQVLPLMWNYSMASTLTKSQYSGYTKAINKMSSDIQKHHIAKLDDKVNDIGEDAFHKVIEPTIMKKEDPETVAAKNIEVAAMQPVKKKTGSSYGETLPQSKSILNSKPLNPKNALATRGFPTRILNSPPQTPSSRTGSKVMTKGGSNDASSTKVEEEFNEFQSFSSTGSIRQTSAPSDVWMNSTPSPTPTSASSTNLPPGFSISLQPNKRKDGSSDIPRSNVYGSLI
SIO_010081: YGL083W
subclass of: SO_0000673
so part of: YGL083W
location: 353058..355472
location: region:353058-355472:1
so has part: feature:353058-355472:1:exon

NP_011432.1
type: Protein
SIO_000068: ncbiprotein

S000003051
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:353058-355472:1:exon

YGL082W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL082W
so part of: sequence
location: <355827..>356972
location: region:355827-356972:1
so has part: feature:355827-356972:1:exon
subclass of: SO_0000010

852798
type: Gene
SIO_000068: ncbigene

position:355827:1
position: 355827
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:356972:1
position: 356972
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:355827-356972:1:exon

YGL082W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL082W
product: uncharacterized protein
transcript id: NM_001180947.3
SIO_010081: YGL082W
subclass of: SO_0000673
so part of: YGL082W
location: <355827..>356972
location: region:355827-356972:1
so has part: feature:355827-356972:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:355827-356972:1:exon

YGL082W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL082W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; MINDY family deubiquitinase that does not appear to contain catalytic activity; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; not an essential gene; YGL082W has a paralog, YPL191C, that arose from the whole genome duplication; ortholog of human MINDY1/FAM63A
codon start: 1
product: uncharacterized protein
translation: MDVTFLTKNVQINGTQFKILLQNGQGECALIALANVLLISPAHARYAQEISRLVRGKETVTLNELVQTLADMGVQNPNGTDVDKQQLLQILPQLYSGLNINPEFNGSFEDGVEMSIFRLYNVGIVHGWIIDGDNDPNSYEHVSKYSYMGAQKVLVQSYEIQKNNAQFENSEQIQSDAPYLKSFLARSATQLTEYGLTHLREILVERSYAVLFRNDHFCTLYKNNGELFTLVTDPTYRNRKDINWQSLKSVNGSQDSYYTGNFIPTSLERTETTATGQNESYISNPFSDQNTGHVTSNQVNSGASGVQQIEDDEELARRLQEQEDMRAANNMQNGYANNGRNHQRERFERPEKNSKKNKFLPFNGSNKEKKRDKLKKNCVIM
SIO_010081: YGL082W
subclass of: SO_0000673
so part of: YGL082W
location: 355827..356972
location: region:355827-356972:1
so has part: feature:355827-356972:1:exon

NP_011433.3
type: Protein
SIO_000068: ncbiprotein

S000003050
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:355827-356972:1:exon

YGL081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL081W
so part of: sequence
location: <357377..>358339
location: region:357377-358339:1
so has part: feature:357377-358339:1:exon
subclass of: SO_0000010

852799
type: Gene
SIO_000068: ncbigene

position:357377:1
position: 357377
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:358339:1
position: 358339
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:357377-358339:1:exon

YGL081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL081W
product: uncharacterized protein
transcript id: NM_001180946.1
SIO_010081: YGL081W
subclass of: SO_0000673
so part of: YGL081W
location: <357377..>358339
location: region:357377-358339:1
so has part: feature:357377-358339:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:357377-358339:1:exon

YGL081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL081W
note: hypothetical protein; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
codon start: 1
product: uncharacterized protein
translation: MGDIRTFVFAIEDTETTQGLCKTIGRSSSFDQNSLCKPYNLYFDEPELSRQHAVLCIKTPIPKIEGVPSIEQLRICIRDLNNKTGTVNLVSDGPNDEIDLKNGDAFGLIAIDNHPFRDNHHLAAKLIFRIELEYFDEAREIVKCTITNVTFGKNNTVSSFPIHSATSTEDSDSSWYGLSEASTQTEVADECHETNTILTRGGRFSILSLRKRGSKQDQKICSNFDRKIHETSSFEEEIEVCTDTDTTEEKEEEEEKEEGDDEEGEIELEIIRVKRIKGRTKIKKTLTCFSKNKKIITPQHSNSMWLLLIVILIFDRLLSN
SIO_010081: YGL081W
subclass of: SO_0000673
so part of: YGL081W
location: 357377..358339
location: region:357377-358339:1
so has part: feature:357377-358339:1:exon

NP_011434.1
type: Protein
SIO_000068: ncbiprotein

S000003049
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:357377-358339:1:exon

YGL080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP37
gene: MPC1
locus tag: YGL080W
gene synonym: FMP37
so part of: sequence
location: <358636..>359028
location: region:358636-359028:1
so has part: feature:358636-359028:1:exon
subclass of: SO_0000010

852800
type: Gene
SIO_000068: ncbigene

position:358636:1
position: 358636
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:359028:1
position: 359028
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358636-359028:1:exon

YGL080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP37
gene: MPC1
locus tag: YGL080W
gene synonym: FMP37
product: pyruvate transporter MPC1
transcript id: NM_001180945.1
SIO_010081: YGL080W
subclass of: SO_0000673
so part of: YGL080W
location: <358636..>359028
location: region:358636-359028:1
so has part: feature:358636-359028:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:358636-359028:1:exon

YGL080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP37
gene: MPC1
locus tag: YGL080W
gene synonym: FMP37
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22628554|PMID:22628558]
experiment: EXISTENCE:direct assay:GO:0006850 mitochondrial pyruvate transmembrane transport [PMID:25672363]
experiment: EXISTENCE:direct assay:GO:0050833 pyruvate transmembrane transporter activity [PMID:25672363]
experiment: EXISTENCE:mutant phenotype:GO:0006850 mitochondrial pyruvate transmembrane transport [PMID:22628554|PMID:22628558]
experiment: EXISTENCE:mutant phenotype:GO:0050833 pyruvate transmembrane transporter activity [PMID:22628554|PMID:22628558]
note: Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia
codon start: 1
product: pyruvate transporter MPC1
translation: MSQPVQRAAARSFLQKYINKETLKYIFTTHFWGPVSNFGIPIAAIYDLKKDPTLISGPMTFALVTYSGVFMKYALSVSPKNYLLFGCHLINETAQLAQGYRFLKYTYFTTDEEKKALDKEWKEKEKTGKQ
SIO_010081: YGL080W
subclass of: SO_0000673
so part of: YGL080W
location: 358636..359028
location: region:358636-359028:1
so has part: feature:358636-359028:1:exon

NP_011435.1
type: Protein
SIO_000068: ncbiprotein

S000003048
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:358636-359028:1:exon

YGL079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KXD1
locus tag: YGL079W
so part of: sequence
location: <359444..>360100
location: region:359444-360100:1
so has part: feature:359444-360100:1:exon
subclass of: SO_0000010

852801
type: Gene
SIO_000068: ncbigene

position:359444:1
position: 359444
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360100:1
position: 360100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359444-360100:1:exon

YGL079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KXD1
locus tag: YGL079W
product: Kxd1p
transcript id: NM_001180944.1
SIO_010081: YGL079W
subclass of: SO_0000673
so part of: YGL079W
location: <359444..>360100
location: region:359444-360100:1
so has part: feature:359444-360100:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359444-360100:1:exon

YGL079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KXD1
locus tag: YGL079W
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]
note: Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
codon start: 1
product: Kxd1p
translation: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
SIO_010081: YGL079W
subclass of: SO_0000673
so part of: YGL079W
location: 359444..360100
location: region:359444-360100:1
so has part: feature:359444-360100:1:exon

NP_011436.1
type: Protein
SIO_000068: ncbiprotein

S000003047
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359444-360100:1:exon

YGL078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DBP3
locus tag: YGL078C
so part of: sequence
location: complement(<360288..>361859)
location: region:360288-361859:-1
so has part: feature:360288-361859:-1:exon
subclass of: SO_0000010

852802
type: Gene
SIO_000068: ncbigene

position:360288:-1
position: 360288
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361859:-1
position: 361859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360288-361859:-1:exon

YGL078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DBP3
locus tag: YGL078C
product: RNA-dependent ATPase DBP3
transcript id: NM_001180943.3
SIO_010081: YGL078C
subclass of: SO_0000673
so part of: YGL078C
location: complement(<360288..>361859)
location: region:360288-361859:-1
so has part: feature:360288-361859:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360288-361859:-1:exon

YGL078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DBP3
locus tag: YGL078C
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9032262]
experiment: EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22083961]
experiment: EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9032262]
note: RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
codon start: 1
product: RNA-dependent ATPase DBP3
translation: MTKEEIADKKRKVVDEEVIEKKKSKKHKKDKKDKKEKKDKKHKKHKKEKKGEKEVEVPEKESEKKPEPTSAVASEFYVQSEALTSLPQSDIDEYFKENEIAVEDSLDLALRPLLSFDYLSLDSSIQAEISKFPKPTPIQAVAWPYLLSGKDVVGVAETGSGKTFAFGVPAISHLMNDQKKRGIQVLVISPTRELASQIYDNLIVLTDKVGMQCCCVYGGVPKDEQRIQLKKSQVVVATPGRLLDLLQEGSVDLSQVNYLVLDEADRMLEKGFEEDIKNIIRETDASKRQTLMFTATWPKEVRELASTFMNNPIKVSIGNTDQLTANKRITQIVEVVDPRGKERKLLELLKKYHSGPKKNEKVLIFALYKKEAARVERNLKYNGYNVAAIHGDLSQQQRTQALNEFKSGKSNLLLATDVAARGLDIPNVKTVINLTFPLTVEDYVHRIGRTGRAGQTGTAHTLFTEQEKHLAGGLVNVLNGANQPVPEDLIKFGTHTKKKEHSAYGSFFKDVDLTKKPKKITFD
SIO_010081: YGL078C
subclass of: SO_0000673
so part of: YGL078C
location: complement(360288..361859)
location: region:360288-361859:-1
so has part: feature:360288-361859:-1:exon

NP_011437.3
type: Protein
SIO_000068: ncbiprotein

S000003046
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360288-361859:-1:exon

YGL077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTR1
gene: HNM1
locus tag: YGL077C
gene synonym: CTR1
so part of: sequence
location: complement(<362225..>363916)
location: region:362225-363916:-1
so has part: feature:362225-363916:-1:exon
subclass of: SO_0000010

852803
type: Gene
SIO_000068: ncbigene

position:362225:-1
position: 362225
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:363916:-1
position: 363916
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:362225-363916:-1:exon

YGL077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTR1
gene: HNM1
locus tag: YGL077C
gene synonym: CTR1
product: Hnm1p
transcript id: NM_001180942.1
SIO_010081: YGL077C
subclass of: SO_0000673
so part of: YGL077C
location: complement(<362225..>363916)
location: region:362225-363916:-1
so has part: feature:362225-363916:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:362225-363916:-1:exon

YGL077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTR1
gene: HNM1
locus tag: YGL077C
gene synonym: CTR1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015220 choline transmembrane transporter activity [PMID:2203793|PMID:3514579]
experiment: EXISTENCE:mutant phenotype:GO:0015871 choline transport [PMID:2203793]
experiment: EXISTENCE:mutant phenotype:GO:0031460 glycine betaine transport [PMID:16487344]
experiment: EXISTENCE:mutant phenotype:GO:0034228 ethanolamine transmembrane transporter activity [PMID:3514579]
experiment: EXISTENCE:mutant phenotype:GO:0034229 ethanolamine transport [PMID:3514579]
experiment: EXISTENCE:mutant phenotype:GO:1900749 (R)-carnitine transport [PMID:23755272]
experiment: EXISTENCE:mutant phenotype:GO:1901235 (R)-carnitine transmembrane transporter activity [PMID:23755272]
note: Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
codon start: 1
product: Hnm1p
translation: MSIRNDNASGGYMQPDQSSNASMHKRDLRVEEEIKPLDDMDSKGAVAADGEVHLRKSFSLWSILGVGFGLTNSWFGISTSMVAGISSGGPMMIVYGIIIVALISICIGTSLGELSSAYPHAGGQFWWSLKLAPPKYKRFAAYMCGSFAYAGSVFTSASTTLSVATEVVGMYALTHPEFIPKRWHIFVCFELLHLFLMFFNCYGKSLPIISSSSLYISLLSFFTITITVLACSHGKFNDAKFVFATFNNETGWKNGGIAFIVGLINPAWSFSCLDCATHMAFEVEKPERVIPIAIMGTVAIGFVTSFCYVIAMFFSIQDLDAVLSSTTGAPILDIYNQALGNKSGAIFLGCLILFTSFGCVIACHTWQARLCWSFARDNGLPLSRLWSQVNPHTGVPLNAHLMSCAWITLIGLLYLASSTAFQSLITGCIAFLLLSYIIPVICLLAKKRNIAHGPFWLGKFGFFSNIVLLGWTVFSVVFFSFPPVLPVTKDNMNYVCVVIVGYTAYSILYWKYKGKKEFHALEESENEQAEYSNNFDTIEDSREFSVAASDVELENEHVPWGKK
SIO_010081: YGL077C
subclass of: SO_0000673
so part of: YGL077C
location: complement(362225..363916)
location: region:362225-363916:-1
so has part: feature:362225-363916:-1:exon

NP_011438.1
type: Protein
SIO_000068: ncbiprotein

S000003045
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:362225-363916:-1:exon

YGL076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL7A
locus tag: YGL076C
so part of: sequence
location: complement(<364335..>365996)
location: region:364335-365996:-1
so has part: feature:364335-365996:-1:exon
subclass of: SO_0000010

852804
type: Gene
SIO_000068: ncbigene

position:364335:-1
position: 364335
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:365996:-1
position: 365996
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364335-365996:-1:exon

YGL076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL7A
locus tag: YGL076C
product: ribosomal 60S subunit protein L7A
transcript id: NM_001180941.1
SIO_010081: YGL076C
subclass of: SO_0000673
so part of: YGL076C
location: complement(join(<364335..364964,365433..365526,365986..>365996))
location: region:364335-365996:-1
so has part: feature:365986-365996:-1:exon
so has part: feature:365433-365526:-1:exon
so has part: feature:364335-364964:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:365986-365996:-1:exon

position:365986:-1
position: 365986
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:365433-365526:-1:exon

position:365433:-1
position: 365433
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:365526:-1
position: 365526
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 3
SIO_000628: feature:364335-364964:-1:exon

position:364964:-1
position: 364964
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL7A
locus tag: YGL076C
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19466602]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]
experiment: EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]
note: Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L7A
translation: MAAEKILTPESQLKKSKAQQKTAEQVAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLVKSMN
SIO_010081: YGL076C
subclass of: SO_0000673
so part of: YGL076C
location: complement(join(364335..364964,365433..365526,365986..365996))
location: region:364335-365996:-1
so has part: feature:365986-365996:-1:exon
so has part: feature:365433-365526:-1:exon
so has part: feature:364335-364964:-1:exon

NP_011439.1
type: Protein
SIO_000068: ncbiprotein

S000003044
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:365986-365996:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:365433-365526:-1:exon

urn:…
SIO_000300: 3
SIO_000628: feature:364335-364964:-1:exon

YNCG0014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR39
locus tag: YNCG0014C
so part of: sequence
location: complement(365163..365251)
location: region:365163-365251:-1
so has part: feature:365163-365251:-1:exon
subclass of: SO_0000578

9164895
type: Gene
SIO_000068: ncbigene

position:365163:-1
position: 365163
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:365251:-1
position: 365251
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:365163-365251:-1:exon

YNCG0014C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR39
locus tag: YNCG0014C
product: SNR39
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:8674114]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:8674114]
experiment: EXISTENCE:physical interaction:GO:0031428 box C/D RNP complex [PMID:10733567]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position A807
transcript id: NR_132180.1
SIO_010081: YNCG0014C
subclass of: SO_0000673
so part of: YNCG0014C
location: complement(365163..365251)
location: region:365163-365251:-1
so has part: feature:365163-365251:-1:exon

S000007302
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:365163-365251:-1:exon

YNCG0015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR39B
locus tag: YNCG0015C
so part of: sequence
location: complement(366374..366469)
location: region:366374-366469:-1
so has part: feature:366374-366469:-1:exon
subclass of: SO_0000578

9164896
type: Gene
SIO_000068: ncbigene

position:366374:-1
position: 366374
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:366469:-1
position: 366469
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366374-366469:-1:exon

YNCG0015C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR39B
locus tag: YNCG0015C
product: SNR39B
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position G805
transcript id: NR_132181.1
SIO_010081: YNCG0015C
subclass of: SO_0000673
so part of: YNCG0015C
location: complement(366374..366469)
location: region:366374-366469:-1
so has part: feature:366374-366469:-1:exon

S000007303
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366374-366469:-1:exon

YGL075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMC1
gene: MPS2
locus tag: YGL075C
gene synonym: MMC1
so part of: sequence
location: complement(<366925..>368088)
location: region:366925-368088:-1
so has part: feature:366925-368088:-1:exon
subclass of: SO_0000010

852805
type: Gene
SIO_000068: ncbigene

position:366925:-1
position: 366925
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:368088:-1
position: 368088
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366925-368088:-1:exon

YGL075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMC1
gene: MPS2
locus tag: YGL075C
gene synonym: MMC1
product: Mps2p
transcript id: NM_001180940.1
SIO_010081: YGL075C
subclass of: SO_0000673
so part of: YGL075C
location: complement(<366925..>368088)
location: region:366925-368088:-1
so has part: feature:366925-368088:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366925-368088:-1:exon

YGL075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMC1
gene: MPS2
locus tag: YGL075C
gene synonym: MMC1
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:32967926]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10397772]
experiment: EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:32059771]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10397772]
experiment: EXISTENCE:direct assay:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32967926]
experiment: EXISTENCE:direct assay:GO:0044821 meiotic telomere tethering at nuclear periphery [PMID:32967926]
experiment: EXISTENCE:direct assay:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32967926]
experiment: EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:10654940]
experiment: EXISTENCE:mutant phenotype:GO:0000741 karyogamy [PMID:16923827]
experiment: EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10654940|PMID:16923827|PMID:1869587]
experiment: EXISTENCE:mutant phenotype:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32059771]
experiment: EXISTENCE:mutant phenotype:GO:0071988 protein localization to spindle pole body [PMID:16923827]
experiment: EXISTENCE:mutant phenotype:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32059771]
note: Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication
codon start: 1
product: Mps2p
translation: MSNGAFDAIFEYAWGQIDKPISGDFIYGKDLPKLIEIIENIFQKAQKSGSYELRLPLFSEINKDLFRTFSNTKTFFKIHKEEFDDIFFNLVNHPLREILENAFIGVDSIPSDFIVSMNLNSPSKFLVENKNKNTEGAGISTPRKKLTESPIKLLSRNNIGKALEVQVEELKRELTAKQSLLQENERQVSELKIRLETYQEKYASIQQRFSDLQKARQVEDNQNSSRTSDPGSPLVTGIDQKAILEEFRRRLQRQTDTISFLKDQIRRERGLNCSNDKVSHSKRKHATTDGDGTFKNFISAVPSNIWVKATIRIIVCFALLAGVLPYIRKYVYAHDTPSQNSRLQLSWWENSGILSKIVWFFEDQTDLETEYRSNANVDDAYSRVFGI
SIO_010081: YGL075C
subclass of: SO_0000673
so part of: YGL075C
location: complement(366925..368088)
location: region:366925-368088:-1
so has part: feature:366925-368088:-1:exon

NP_011440.1
type: Protein
SIO_000068: ncbiprotein

S000003043
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366925-368088:-1:exon

YGL073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EXA3
alternative label: MAS3
gene: HSF1
locus tag: YGL073W
gene synonym: EXA3; MAS3
so part of: sequence
location: <368753..>371254
location: region:368753-371254:1
so has part: feature:368753-371254:1:exon
subclass of: SO_0000010

852806
type: Gene
SIO_000068: ncbigene

position:368753:1
position: 368753
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:371254:1
position: 371254
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:368753-371254:1:exon

YGL073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EXA3
alternative label: MAS3
gene: HSF1
locus tag: YGL073W
gene synonym: EXA3; MAS3
product: stress-responsive transcription factor HSF1
transcript id: NM_001180938.3
SIO_010081: YGL073W
subclass of: SO_0000673
so part of: YGL073W
location: <368753..>371254
location: region:368753-371254:1
so has part: feature:368753-371254:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:368753-371254:1:exon

YGL073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EXA3
alternative label: MAS3
gene: HSF1
locus tag: YGL073W
gene synonym: EXA3; MAS3
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:3044612]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12821147]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:3044612]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:31124783]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:2017170|PMID:3044612|PMID:8985158]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27320198|PMID:9296388]
experiment: EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:18270585]
note: Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses and transient intracellular acidification; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status of cell through an RQC (Ribosomal Quality Control)-mediated translation-stress signal; involved in diauxic shift; posttranslationally regulated; human homolog HSF1 with linker region mutations can complement yeast hsf1 mutant
codon start: 1
product: stress-responsive transcription factor HSF1
translation: MNNAANTGTTNESNVSDAPRIEPLPSLNDDDIEKILQPNDIFTTDRTDASTTSSTAIEDIINPSLDPQSAASPVPSSSFFHDSRKPSTSTHLVRRGTPLGIYQTNLYGHNSRENTNPNSTLLSSKLLAHPPVPYGQNPDLLQHAVYRAQPSSGTTNAQPRQTTRRYQSHKSRPAFVNKLWSMLNDDSNTKLIQWAEDGKSFIVTNREEFVHQILPKYFKHSNFASFVRQLNMYGWHKVQDVKSGSIQSSSDDKWQFENENFIRGREDLLEKIIRQKGSSNNHNSPSGNGNPANGSNIPLDNAAGSNNSNNNISSSNSFFNNGHLLQGKTLRLMNEANLGDKNDVTAILGELEQIKYNQIAISKDLLRINKDNELLWQENMMARERHRTQQQALEKMFRFLTSIVPHLDPKMIMDGLGDPKVNNEKLNSANNIGLNRDNTGTIDELKSNDSFINDDRNSFTNATTNARNNMSPNNDDNSIDTASTNTTNRKKNIDENIKNNNDIINDIIFNTNLANNLSNYNSNNNAGSPIRPYKQRYLLKNRANSSTSSENPSLTPFDIESNNDRKISEIPFDDEEEEETDFRPFTSRDPNNQTSENTFDPNRFTMLSDDDLKKDSHTNDNKHNESDLFWDNVHRNIDEQDARLQNLENMVHILSPGYPNKSFNNKTSSTNTNSNMESAVNVNSPGFNLQDYLTGESNSPNSVHSVPSNGSGSTPLPMPNDNDTEHASTSVNQGENGSGLTPFLTVDDHTLNDNNTSEGSTRVSPDIKFSATENTKVSDNLPSFNDHSYSTQADTAPENAKKRFVEEIPEPAIVEIQDPTEYNDHRLPKRAKK
SIO_010081: YGL073W
subclass of: SO_0000673
so part of: YGL073W
location: 368753..371254
location: region:368753-371254:1
so has part: feature:368753-371254:1:exon

NP_011442.3
type: Protein
SIO_000068: ncbiprotein

S000003041
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:368753-371254:1:exon

YGL071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RCS1
gene: AFT1
locus tag: YGL071W
gene synonym: RCS1
so part of: sequence
location: <372012..>374084
location: region:372012-374084:1
so has part: feature:372012-374084:1:exon
subclass of: SO_0000010

852809
type: Gene
SIO_000068: ncbigene

position:372012:1
position: 372012
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374084:1
position: 374084
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372012-374084:1:exon

YGL071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RCS1
gene: AFT1
locus tag: YGL071W
gene synonym: RCS1
product: DNA-binding transcription factor AFT1
transcript id: NM_001180936.1
SIO_010081: YGL071W
subclass of: SO_0000673
so part of: YGL071W
location: <372012..>374084
location: region:372012-374084:1
so has part: feature:372012-374084:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372012-374084:1:exon

YGL071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RCS1
gene: AFT1
locus tag: YGL071W
gene synonym: RCS1
experiment: EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:27402848|PMID:8670839]
experiment: EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8670839]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11877447|PMID:22842922|PMID:16911514]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11877447|PMID:16911514|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:16172405]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14739928]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16172405]
experiment: EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]
experiment: EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:22157760]
experiment: EXISTENCE:mutant phenotype:GO:0034758 positive regulation of iron ion transport [PMID:7720713]
experiment: EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:22157760]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:32147528|PMID:12095998|PMID:7720713]
note: Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: DNA-binding transcription factor AFT1
translation: MEGFNPADIEHASPINSSDSHSSSFVYALPKSASEYVVNHNEGRASASGNPAAVPSPIMTLNLKSTHSLNIDQHVHTSTSPTETIGHIHHVEKLNQNNLIHLDPVPNFEDKSDIKPWLQKIFYPQGIELVIERSDAFKVVFKCKAAKRGRNARRKRKDKPKGQDHEDEKSKINDDELEYASPSNATVTNGPQTSPDQTSSIKPKKKRCVSRFNNCPFRVRATYSLKRKRWSIVVMDNNHSHQLKFNPDSEEYKKFKEKLRKDNDVDAIKKFDELEYRTLANLPIPTATIPCDCGLTNEIQSFNVVLPTNSNVTSSASSSTVSSISLDSSNASKRPCLPSVNNTGSINTNNVRKPKSQCKNKDTLLKRTTMQNFLTTKSRLRKTGTPTSSQHSSTAFSGYIDDPFNLNEILPLPASDFKLNTVTNLNEIDFTNIFTKSPHPHSGSTHPRQVFDQLDDCSSILFSPLTTNTNNEFEGESDDFVHSPYLNSEADFSQILSSAPPVHHDPNETHQENQDIIDRFANSSQEHNEYILQYLTHSDAANHNNIGVPNNNSHSLNTQHNVSDLGNSLLRQEALVGSSSTKIFDELKFVQNGPHGSQHPIDFQHVDHRHLSSNEPQVRSHQYGPQQQPPQQLQYHQNQPHDGHNHEQHQTVQKDMQTHESLEIMGNTLLEEFKDIKMVNGELKYVKPED
SIO_010081: YGL071W
subclass of: SO_0000673
so part of: YGL071W
location: 372012..374084
location: region:372012-374084:1
so has part: feature:372012-374084:1:exon

NP_011444.1
type: Protein
SIO_000068: ncbiprotein

S000003039
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372012-374084:1:exon

YGL070C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSU73
gene: RPB9
locus tag: YGL070C
gene synonym: SSU73
so part of: sequence
location: complement(<374459..>374827)
location: region:374459-374827:-1
so has part: feature:374459-374827:-1:exon
subclass of: SO_0000010

852810
type: Gene
SIO_000068: ncbigene

position:374459:-1
position: 374459
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374827:-1
position: 374827
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:374459-374827:-1:exon

YGL070C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSU73
gene: RPB9
locus tag: YGL070C
gene synonym: SSU73
product: DNA-directed RNA polymerase II core subunit RPB9
transcript id: NM_001180935.1
SIO_010081: YGL070C
subclass of: SO_0000673
so part of: YGL070C
location: complement(<374459..>374827)
location: region:374459-374827:-1
so has part: feature:374459-374827:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:374459-374827:-1:exon

YGL070C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSU73
gene: RPB9
locus tag: YGL070C
gene synonym: SSU73
experiment: EXISTENCE:direct assay:GO:0003968 RNA-dependent RNA polymerase activity [PMID:18004386]
experiment: EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]
experiment: EXISTENCE:genetic interaction:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:17535246]
experiment: EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17030604]
experiment: EXISTENCE:mutant phenotype:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:16492753]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:17179178]
experiment: EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:7800482]
note: RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription; positively regulates ATG1 transcription as a key regulator of autophagy
codon start: 1
product: DNA-directed RNA polymerase II core subunit RPB9
translation: MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYVEEAGSPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLSCSHIFTSDQKNKRTQFS
SIO_010081: YGL070C
subclass of: SO_0000673
so part of: YGL070C
location: complement(374459..374827)
location: region:374459-374827:-1
so has part: feature:374459-374827:-1:exon

NP_011445.1
type: Protein
SIO_000068: ncbiprotein

S000003038
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:374459-374827:-1:exon

YGL068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bL12m
gene: MNP1
locus tag: YGL068W
gene synonym: bL12m
so part of: sequence
location: <375087..>375671
location: region:375087-375671:1
so has part: feature:375087-375671:1:exon
subclass of: SO_0000010

852811
type: Gene
SIO_000068: ncbigene

position:375087:1
position: 375087
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:375671:1
position: 375671
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375087-375671:1:exon

YGL068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bL12m
gene: MNP1
locus tag: YGL068W
gene synonym: bL12m
product: mitochondrial nucleoid protein MNP1
transcript id: NM_001180933.1
SIO_010081: YGL068W
subclass of: SO_0000673
so part of: YGL068W
location: <375087..>375671
location: region:375087-375671:1
so has part: feature:375087-375671:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:375087-375671:1:exon

YGL068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bL12m
gene: MNP1
locus tag: YGL068W
gene synonym: bL12m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:24675956]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15221522]
note: Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth
codon start: 1
product: mitochondrial nucleoid protein MNP1
translation: MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE
SIO_010081: YGL068W
subclass of: SO_0000673
so part of: YGL068W
location: 375087..375671
location: region:375087-375671:1
so has part: feature:375087-375671:1:exon

NP_011447.1
type: Protein
SIO_000068: ncbiprotein

S000003036
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375087-375671:1:exon

YGL067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NPY1
locus tag: YGL067W
so part of: sequence
location: <376101..>377255
location: region:376101-377255:1
so has part: feature:376101-377255:1:exon
subclass of: SO_0000010

852813
type: Gene
SIO_000068: ncbigene

position:376101:1
position: 376101
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:377255:1
position: 377255
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:376101-377255:1:exon

YGL067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NPY1
locus tag: YGL067W
product: NAD(+) diphosphatase
transcript id: NM_001180932.3
SIO_010081: YGL067W
subclass of: SO_0000673
so part of: YGL067W
location: <376101..>377255
location: region:376101-377255:1
so has part: feature:376101-377255:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:376101-377255:1:exon

YGL067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NPY1
locus tag: YGL067W
EC number: 3.6.1.22
experiment: EXISTENCE:direct assay:GO:0000210 NAD+ diphosphatase activity [PMID:11361135]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:11361135]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006734 NADH metabolic process [PMID:11361135]
experiment: EXISTENCE:mutant phenotype:GO:0110154 RNA decapping [PMID:34074215]
experiment: EXISTENCE:mutant phenotype:GO:0110155 NAD-cap decapping [PMID:33139726]
note: NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; enzymatic component of one of several partly redundant surveillance pathways involved in decapping of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); also possesses deCoAping activity involved in the decapping of non-canonical dephospho-CoA capped RNA (dpCoA-RNA); nudix hydrolase family member
codon start: 1
product: NAD(+) diphosphatase
translation: MSTAVTFFGQHVLNRVSFLRCSKEFIKKSLNHDSTVFIPFIEGEALISPENGDLVQLSNSVKSYKNILSAIVPLYTTLLNTTRSRSDESGINVTFLGLLEGTDSAFNFEWSNISYKGTPYFGLDIRVTESTLFKKVDFEPIFSYPKVTRDHIFKQTNEDASLYSQGKMYLDWLAKYKFCPGCGSPLFPVEAGTKLQCSNENRNVYCNVRDARINNVCFPRTDPTVIIALTNSDYSKCCLARSKKRYGDFVLYSTIAGFMEPSETIEEACIREIWEETGISCKNIDIVRSQPWPYPCSLMIGCLGIVQFNSKNEVINLNHDDELLDAQWFDTTEIIQALDKYAGGYRVPFKNDINLPGSTTIAFQLINHVCENYKNLRKTSSSHL
SIO_010081: YGL067W
subclass of: SO_0000673
so part of: YGL067W
location: 376101..377255
location: region:376101-377255:1
so has part: feature:376101-377255:1:exon

NP_011448.3
type: Protein
SIO_000068: ncbiprotein

S000003035
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:376101-377255:1:exon

YGL066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCA7
gene: SGF73
locus tag: YGL066W
gene synonym: SCA7
so part of: sequence
location: <377609..>379582
location: region:377609-379582:1
so has part: feature:377609-379582:1:exon
subclass of: SO_0000010

852814
type: Gene
SIO_000068: ncbigene

position:377609:1
position: 377609
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:379582:1
position: 379582
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:377609-379582:1:exon

YGL066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCA7
gene: SGF73
locus tag: YGL066W
gene synonym: SCA7
product: deubiquitination module subunit SGF73
transcript id: NM_001180931.1
SIO_010081: YGL066W
subclass of: SO_0000673
so part of: YGL066W
location: <377609..>379582
location: region:377609-379582:1
so has part: feature:377609-379582:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:377609-379582:1:exon

YGL066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCA7
gene: SGF73
locus tag: YGL066W
gene synonym: SCA7
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:17090597|PMID:12052880]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:18488019]
experiment: EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:31165730]
experiment: EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]
experiment: EXISTENCE:direct assay:GO:1905634 regulation of protein localization to chromatin [PMID:31165730]
experiment: EXISTENCE:genetic interaction:GO:0005198 structural molecule activity [PMID:15932941]
experiment: EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:15932941]
experiment: EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15932941]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:17090597|PMID:15932941]
experiment: EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:18488019]
experiment: EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:20434206]
experiment: EXISTENCE:mutant phenotype:GO:0016573 histone acetylation [PMID:15932941]
experiment: EXISTENCE:mutant phenotype:GO:0016578 histone deubiquitination [PMID:19226466|PMID:25526805]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17090597]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:19226466]
experiment: EXISTENCE:physical interaction:GO:0000124 SAGA complex [PMID:15932941]
experiment: EXISTENCE:physical interaction:GO:0046695 SLIK (SAGA-like) complex [PMID:15932941]
note: Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant
codon start: 1
product: deubiquitination module subunit SGF73
translation: MRSGDAEIKGIKPKVIEEYSLSQGSGPSNDSWKSLMSSAKDTPLQYDHMNRESLKKYFNPNAQLIEDPLDKPIQYRVCEKCGKPLALTAIVDHLENHCAGASGKSSTDPRDESTRETIRNGVESTGRNNNDDDNSNDNNNDDDDDDDNDDNEDDDDADDDDDNSNGANYKKNDSSFNPLKRSTSMESANTPNMDTKRSKTGTPQTFSSSIKKQKKVKQRNPTEKHLIDFNKQCGVELPEGGYCARSLTCKSHSMGAKRAVSGRSKPYDVLLADYHREHQTKIGAAAEKRAKQQELQKLQKQIQKEQKKHTQQQKQGQRSKQRNVNGGKSAKNGGKSTVHNGNNINEIGHVNLTPEEETTQVLNGVSRSFPLPLESTVLSSVRYRTKYFRMREMFASSFSVKPGYTSPGYGAIHSRVGCLDLDRTTDYKFRVRTPQPINHLTNQNLNPKQIQRLQQQRALQAQLLSQQQQQQQQQQQHHSPQAQAQASTQQPTQGMVPNHFPGGATNSSFNANVSSKQIQQQQQQQQHKSQDTGLTPLEIQSQQQKLRQQQLQQQKFEAAASYLANATKLMQESNQDSHLSGTHNNNSSKNGNNNLMTMKASISSPNTSVNSIQSPPSVNSVNGSGQGVSTGINVSGNNGRIEVGIGNSVNPYNGRIN
SIO_010081: YGL066W
subclass of: SO_0000673
so part of: YGL066W
location: 377609..379582
location: region:377609-379582:1
so has part: feature:377609-379582:1:exon

NP_011449.1
type: Protein
SIO_000068: ncbiprotein

S000003034
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:377609-379582:1:exon

YGL065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALG2
locus tag: YGL065C
so part of: sequence
location: complement(<379760..>381271)
location: region:379760-381271:-1
so has part: feature:379760-381271:-1:exon
subclass of: SO_0000010

852815
type: Gene
SIO_000068: ncbigene

position:379760:-1
position: 379760
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:381271:-1
position: 381271
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:379760-381271:-1:exon

YGL065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALG2
locus tag: YGL065C
product: GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
transcript id: NM_001180930.1
SIO_010081: YGL065C
subclass of: SO_0000673
so part of: YGL065C
location: complement(<379760..>381271)
location: region:379760-381271:-1
so has part: feature:379760-381271:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:379760-381271:-1:exon

YGL065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALG2
locus tag: YGL065C
EC number: 2.4.1.132
EC number: 2.4.1.257
experiment: EXISTENCE:direct assay:GO:0004378 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity [PMID:16878994]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006490 oligosaccharide-lipid intermediate biosynthetic process [PMID:16878994]
experiment: EXISTENCE:direct assay:GO:0033164 glycolipid 1,6-alpha-mannosyltransferase activity [PMID:16878994]
note: Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement
codon start: 1
product: GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
translation: MIEKDKRTIAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNFLGRFFIVFATIRQLYLVIQLILQKKVNAYQLIIIDQLSTCIPLLHIFSSATLMFYCHFPDQLLAQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEGDRFYLSINRFEKKKDVALAIKAFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPAVPIQWATAIDESRKILQNGSVNFERNGPLRVKKYFSREAMTQSFEENVEKVIWKEKKYYPWEIFGISFSNFILHMAFIKILPNNPWPFLFMATFMVLYFKNYLWGIYWAFVFALSYPYEEI
SIO_010081: YGL065C
subclass of: SO_0000673
so part of: YGL065C
location: complement(379760..381271)
location: region:379760-381271:-1
so has part: feature:379760-381271:-1:exon

NP_011450.1
type: Protein
SIO_000068: ncbiprotein

S000003033
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:379760-381271:-1:exon

YGL064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRH4
locus tag: YGL064C
so part of: sequence
location: complement(<381523..>383208)
location: region:381523-383208:-1
so has part: feature:381523-383208:-1:exon
subclass of: SO_0000010

852816
type: Gene
SIO_000068: ncbigene

position:381523:-1
position: 381523
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:383208:-1
position: 383208
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:381523-383208:-1:exon

YGL064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRH4
locus tag: YGL064C
product: ATP-dependent RNA helicase
transcript id: NM_001180929.1
SIO_010081: YGL064C
subclass of: SO_0000673
so part of: YGL064C
location: complement(<381523..>383208)
location: region:381523-383208:-1
so has part: feature:381523-383208:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:381523-383208:-1:exon

YGL064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRH4
locus tag: YGL064C
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12702275|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:24206665]
experiment: EXISTENCE:direct assay:GO:1990400 mitochondrial ribosomal large subunit rRNA binding [PMID:24206665]
experiment: EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:24206665]
experiment: EXISTENCE:mutant phenotype:GO:0016070 RNA metabolic process [PMID:12702275]
experiment: EXISTENCE:mutant phenotype:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:24206665]
note: Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes
codon start: 1
product: ATP-dependent RNA helicase
translation: MSLFFKPVISPQWSFPVLLKIGVRSYAGGPRTKHKGNSPLASVPTGSSNKNRKQKAKGKKGNKKNDPDQAFNFGEYGGLKKDVEMNMDSTNKLIQKISNFDQLLILPPVRDAVKEIISKESLKLQDSRKKTSENIIPSPIQTVAIKRISKNLMDPKLQIHAIAAETGSGKTMAYLIPLIDYLKRQELETPELWETLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPIMTPRLHKLPFALDFKVINSALSPFKGSKIKALAQTLYAISNDDTEPGFEKRCIIFVNEKKNVPEIVNLLNKKFGHNAIGLTGEDTFEERSEKIMPFLSPPRPLSEVVAQSTSPPTSLKKFEIPDSNIVIGKLKNTNSNGTAPSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTDSKTKSWAKALPKIIKKHQRLS
SIO_010081: YGL064C
subclass of: SO_0000673
so part of: YGL064C
location: complement(381523..383208)
location: region:381523-383208:-1
so has part: feature:381523-383208:-1:exon

NP_011451.1
type: Protein
SIO_000068: ncbiprotein

S000003032
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:381523-383208:-1:exon

YGL063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUS2
locus tag: YGL063W
so part of: sequence
location: <383654..>384766
location: region:383654-384766:1
so has part: feature:383654-384766:1:exon
subclass of: SO_0000010

852817
type: Gene
SIO_000068: ncbigene

position:383654:1
position: 383654
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:384766:1
position: 384766
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:383654-384766:1:exon

YGL063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUS2
locus tag: YGL063W
product: pseudouridine synthase PUS2
transcript id: NM_001180928.4
SIO_010081: YGL063W
subclass of: SO_0000673
so part of: YGL063W
location: <383654..>384766
location: region:383654-384766:1
so has part: feature:383654-384766:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:383654-384766:1:exon

YGL063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUS2
locus tag: YGL063W
EC number: 5.4.99.44
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17684231]
experiment: EXISTENCE:genetic interaction:GO:0009982 pseudouridine synthase activity [PMID:17684231]
experiment: EXISTENCE:genetic interaction:GO:0031119 tRNA pseudouridine synthesis [PMID:17684231]
experiment: EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:17684231]
experiment: EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:17684231]
experiment: EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136]
note: Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication
codon start: 1
product: pseudouridine synthase PUS2
translation: MLLGYCGSGYYGMQYNPPHKTIEGEILTKLFDVGAISEENSLAPKKNSFMAAARTDKGVHAMLNLLSLKITLREDTVAKLNAALPPEIRVWGIQPVNKKFNARSACDSRWYQYLIPEFILIGPPRSSLLHRNVGGCYREDGSQEVWDTFLEQTRGRFSGDELCRLQDTAQKLSESDPLVQDYVGLLSGTLSGYCLSPSKLDAFEAAMQEYVGTHNFHNFTTGKLWGDPSAQRHIKKVVVSQASPGWICVRIHGQSFMLHQIRRMVALAVLAARCQLPPNIVRNYFNAGPRKYIPRAPAQGLLLEGPVFDGYNTKLRNLLYCEIRPDDITLERMCRFRERQICTAIAHEETQRHVFCHFVRQMNRLATPLI
SIO_010081: YGL063W
subclass of: SO_0000673
so part of: YGL063W
location: 383654..384766
location: region:383654-384766:1
so has part: feature:383654-384766:1:exon

NP_011452.4
type: Protein
SIO_000068: ncbiprotein

S000003031
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:383654-384766:1:exon

YGL062W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PYC1
locus tag: YGL062W
so part of: sequence
location: <385196..>388732
location: region:385196-388732:1
so has part: feature:385196-388732:1:exon
subclass of: SO_0000010

852818
type: Gene
SIO_000068: ncbigene

position:385196:1
position: 385196
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:388732:1
position: 388732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:385196-388732:1:exon

YGL062W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PYC1
locus tag: YGL062W
product: pyruvate carboxylase 1
transcript id: NM_001180927.1
SIO_010081: YGL062W
subclass of: SO_0000673
so part of: YGL062W
location: <385196..>388732
location: region:385196-388732:1
so has part: feature:385196-388732:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:385196-388732:1:exon

YGL062W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PYC1
locus tag: YGL062W
EC number: 6.4.1.1
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:196563|PMID:2665820]
experiment: EXISTENCE:mutant phenotype:GO:0004736 pyruvate carboxylase activity [PMID:2039506]
experiment: EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:8185321]
note: Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
codon start: 1
product: pyruvate carboxylase 1
translation: MSQRKFAGLRDNFNLLGEKNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLEDQVPVETKA
SIO_010081: YGL062W
subclass of: SO_0000673
so part of: YGL062W
location: 385196..388732
location: region:385196-388732:1
so has part: feature:385196-388732:1:exon

NP_011453.1
type: Protein
SIO_000068: ncbiprotein

S000003030
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:385196-388732:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS717; Autonomously Replicating Sequence
so part of: sequence
location: 388658..388891
location: region:388658-388891:1
so has part: feature:388658-388891:1:region

S000118457
type: SGD
SIO_000068: sgd

position:388658:1
position: 388658
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:388891:1
position: 388891
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388658-388891:1:region

YGL061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DUO1
locus tag: YGL061C
so part of: sequence
location: complement(<388968..>389711)
location: region:388968-389711:-1
so has part: feature:388968-389711:-1:exon
subclass of: SO_0000010

852819
type: Gene
SIO_000068: ncbigene

position:388968:-1
position: 388968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:389711:-1
position: 389711
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:388968-389711:-1:exon

YGL061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DUO1
locus tag: YGL061C
product: Duo1p
transcript id: NM_001180926.1
SIO_010081: YGL061C
subclass of: SO_0000673
so part of: YGL061C
location: complement(<388968..>389711)
location: region:388968-389711:-1
so has part: feature:388968-389711:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:388968-389711:-1:exon

YGL061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DUO1
locus tag: YGL061C
experiment: EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]
experiment: EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]
experiment: EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]
note: Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
codon start: 1
product: Duo1p
translation: MSEQSQLDDSTIDKLIPQIFNEMRSNLNNTTNKFPKSTGGGASDNISANSNSIRSFNSITTQSLLKESESLDKITAMIKNVTAALKNNLPVYVNQVHEVCKSTNSILDSWINIHSQAGYIHKLMSDQTYLKLINDRLHNENVNTNDEDGSTLHNVIALKKKEILDLRQKLENRKGEKDAAPAKPPNQGLNPRYGVQSGRRPVPSAGISNNGRVRKTHVPASKRPSGIPRVTNRWTKPTASSSRKMFR
SIO_010081: YGL061C
subclass of: SO_0000673
so part of: YGL061C
location: complement(388968..389711)
location: region:388968-389711:-1
so has part: feature:388968-389711:-1:exon

NP_011454.1
type: Protein
SIO_000068: ncbiprotein

S000003029
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:388968-389711:-1:exon

YGL060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YBH1
gene: YBP2
locus tag: YGL060W
gene synonym: YBH1
so part of: sequence
location: <390065..>391990
location: region:390065-391990:1
so has part: feature:390065-391990:1:exon
subclass of: SO_0000010

852820
type: Gene
SIO_000068: ncbigene

position:390065:1
position: 390065
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:391990:1
position: 391990
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390065-391990:1:exon

YGL060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YBH1
gene: YBP2
locus tag: YGL060W
gene synonym: YBH1
product: Ybp2p
transcript id: NM_001180925.1
SIO_010081: YGL060W
subclass of: SO_0000673
so part of: YGL060W
location: <390065..>391990
location: region:390065-391990:1
so has part: feature:390065-391990:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390065-391990:1:exon

YGL060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YBH1
gene: YBP2
locus tag: YGL060W
gene synonym: YBH1
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:18286174]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0007052 mitotic spindle organization [PMID:18286174]
note: Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
codon start: 1
product: Ybp2p
translation: MYNEQVNSGKSIKEKERYLDALLKILKDNPVTLKEIGWDLPKGLLQFFSRKNINVNIHLVFSPLVSSVMECFNELAINGNPKECLLTACELVSTLHIVLTETGDSDEENEDLNDSNRNDASNITDELSVITPEIGHYMAKNTVEFIPNLKIYVLFEFMSLLLKRVDTLYPSKFLAMVTSAIIKYVTTNVQAMDDPHFILRIVYNFCTNYSPAQPSASLTDGISTNDLEKIHDDESALQKKLLANLSVFVISNCLKNHPGNIDKIYFKTLMHKKTDENEIDASVLQICHQYYEYVTSLDVHMKELLEKCLVESRSIYNSLLMNPAASTPEFKEEINQLVYEVSYAYQIKKLADEKNLELDQYGVVILSAIHYSKNGTHLLPQIDIQSAIYLYLRCTTASLFSEIYENKFLESSVRYWLWVSTTETSTEKIKCALQELPGHITTAFLQMLLMKTCNESNNDTKLTEITLLRRLLYLMPESTSFTFIFETLLHCPYITAKIAVLDILRDMMIRSPEAANRDETVGLIEQQNPGNTANSVPIMPTLPPRPYITINEDRMASIHSIALICFSAAKQKKRTQGDLLLVLTYMKFFVSLRNKWDLGLLTLINKEISESFQGEGEPELAFINISNNTLGEYIEEMNIRS
SIO_010081: YGL060W
subclass of: SO_0000673
so part of: YGL060W
location: 390065..391990
location: region:390065-391990:1
so has part: feature:390065-391990:1:exon

NP_011455.1
type: Protein
SIO_000068: ncbiprotein

S000003028
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390065-391990:1:exon

YGL059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PKP2
locus tag: YGL059W
so part of: sequence
location: <392223..>393698
location: region:392223-393698:1
so has part: feature:392223-393698:1:exon
subclass of: SO_0000010

852821
type: Gene
SIO_000068: ncbigene

position:392223:1
position: 392223
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393698:1
position: 393698
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:392223-393698:1:exon

YGL059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PKP2
locus tag: YGL059W
product: protein kinase PKP2
transcript id: NM_001180924.4
SIO_010081: YGL059W
subclass of: SO_0000673
so part of: YGL059W
location: <392223..>393698
location: region:392223-393698:1
so has part: feature:392223-393698:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:392223-393698:1:exon

YGL059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PKP2
locus tag: YGL059W
EC number: 2.7.11.2
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:17918780|PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18180296|PMID:17918780|PMID:14562095|PMID:16823961|P MID:22842922]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]
experiment: EXISTENCE:genetic interaction:GO:0015976 carbon utilization [PMID:17918780]
experiment: EXISTENCE:mutant phenotype:GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity [PMID:18180296]
experiment: EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:18180296]
experiment: EXISTENCE:mutant phenotype:GO:1901524 regulation of mitophagy [PMID:31548421]
experiment: EXISTENCE:mutant phenotype:GO:1904183 negative regulation of pyruvate dehydrogenase activity [PMID:18180296]
note: Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
codon start: 1
product: protein kinase PKP2
translation: MSKYQINCIRYRHFLRTSNISQIPDFTKYCIGPVNEELAPYIMETMKAYPSNSEYINPQHYYHNRTVLVENYLKRSPNPVSLTQLAQYYDDSTKLTRTKIINSGKFVKEELVIRIAHKLNQLQQLPFNVVNNFHFVQVYESYYNIFESFRKYPTIRTLEDASQFADFIKNMLEGFNTLNLPHLIMGALECTILDLYPREKMDQLLSDLLRARISRRLIVEEHVSITANYTSGKEENTLVLGDIFQECSAKKYLLEASEESQKFIQDMYFKDIPMPEFIIEGDTQLSFYFLPTHLKYLLGEILRNTYEATMKHYIRKGLEKPEPIIVTVVSNDESYLFRISDKAGGVLHDDENLWSFGKSKERAQESLNNFHKLPGLQTVSIYDEVHSHTKYNSKLKSLQSITLKPYMHTSLEPMSYPSIINGHIKYETPLIELLKRSFRYKLGIGLAMCKVYAEYWNGDLSLHSMPGYGTDVVLKLGNLMKHTKKLQLDKV
SIO_010081: YGL059W
subclass of: SO_0000673
so part of: YGL059W
location: 392223..393698
location: region:392223-393698:1
so has part: feature:392223-393698:1:exon

NP_011456.5
type: Protein
SIO_000068: ncbiprotein

S000003027
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:392223-393698:1:exon

YGL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSO8
alternative label: UBC2
gene: RAD6
locus tag: YGL058W
gene synonym: PSO8; UBC2
so part of: sequence
location: <393986..>394504
location: region:393986-394504:1
so has part: feature:393986-394504:1:exon
subclass of: SO_0000010

852822
type: Gene
SIO_000068: ncbigene

position:393986:1
position: 393986
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394504:1
position: 394504
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:393986-394504:1:exon

YGL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSO8
alternative label: UBC2
gene: RAD6
locus tag: YGL058W
gene synonym: PSO8; UBC2
product: E2 ubiquitin-conjugating protein RAD6
transcript id: NM_001180923.1
SIO_010081: YGL058W
subclass of: SO_0000673
so part of: YGL058W
location: <393986..>394504
location: region:393986-394504:1
so has part: feature:393986-394504:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:393986-394504:1:exon

YGL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSO8
alternative label: UBC2
gene: RAD6
locus tag: YGL058W
gene synonym: PSO8; UBC2
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:14752010]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9287349]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:3306404|PMID:9287349]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8436296|PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]
experiment: EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:9287349]
experiment: EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]
experiment: EXISTENCE:direct assay:GO:0097505 Rad6-Rad18 complex [PMID:9287349]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:16783014]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:23988329]
experiment: EXISTENCE:genetic interaction:GO:0042275 error-free postreplication DNA repair [PMID:9576943]
experiment: EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:770231]
experiment: EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:9409821]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:1651502|PMID:8436296]
experiment: EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:8436296|PMID:15504724]
experiment: EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:12226657]
experiment: EXISTENCE:mutant phenotype:GO:0010390 histone monoubiquitination [PMID:12535538|PMID:12535539]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:12535539|PMID:9343433]
experiment: EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:15632126|PMID:16166626]
experiment: EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:15280549]
experiment: EXISTENCE:mutant phenotype:GO:0070534 protein K63-linked ubiquitination [PMID:25622294]
experiment: EXISTENCE:mutant phenotype:GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway [PMID:1651502|PMID:8505328]
experiment: EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]
experiment: EXISTENCE:mutant phenotype:GO:0090089 regulation of dipeptide transport [PMID:9427760]
experiment: EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]
experiment: EXISTENCE:mutant phenotype:GO:1990303 UBR1-RAD6 ubiquitin ligase complex [PMID:8505328]
experiment: EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:15632065]
experiment: EXISTENCE:physical interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]
experiment: EXISTENCE:physical interaction:GO:1990303 UBR1-RAD6 ubiquitin ligase complex [PMID:1651502|PMID:8505328]
experiment: EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]
note: Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p
codon start: 1
product: E2 ubiquitin-conjugating protein RAD6
translation: MSTPARRRLMRDFKRMKEDAPPGVSASPLPDNVMVWNAMIIGPADTPYEDGTFRLLLEFDEEYPNKPPHVKFLSEMFHPNVYANGEICLDILQNRWTPTYDVASILTSIQSLFNDPNPASPANVEAATLFKDHKSQYVKRVKETVEKSWEDDMDDMDDDDDDDDDDDDDEAD
SIO_010081: YGL058W
subclass of: SO_0000673
so part of: YGL058W
location: 393986..394504
location: region:393986-394504:1
so has part: feature:393986-394504:1:exon

NP_011457.1
type: Protein
SIO_000068: ncbiprotein

S000003026
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:393986-394504:1:exon

YGL057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GEP7
locus tag: YGL057C
so part of: sequence
location: complement(<394966..>395829)
location: region:394966-395829:-1
so has part: feature:394966-395829:-1:exon
subclass of: SO_0000010

852823
type: Gene
SIO_000068: ncbigene

position:394966:-1
position: 394966
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:395829:-1
position: 395829
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394966-395829:-1:exon

YGL057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GEP7
locus tag: YGL057C
product: Gep7p
transcript id: NM_001180922.1
SIO_010081: YGL057C
subclass of: SO_0000673
so part of: YGL057C
location: complement(<394966..>395829)
location: region:394966-395829:-1
so has part: feature:394966-395829:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394966-395829:-1:exon

YGL057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GEP7
locus tag: YGL057C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]
note: hypothetical protein; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Gep7p
translation: MVLSNVKIFRLKSHRAFRIGPMIKAVAGNLLVKRFYQPKLERIPPASLLLKQKIRLAQNGSTTSTENPISFSQTMSEIFSVLQPSAPDLDEDETSGLKRDHLLTERLNNGELGVIMNKFFNPSSTHNNQLIDTNILLQNFPKLSGNDLDLLDFAINEKMRGNWNDLKQDFIQLWYYKSFGFLGPRTQFVLTNSSPSVRSQFLKLPFIEYNWFLLQNNKNANILPADVQNVVKVFHLDDKRFTWKSIDPFSKAIISFVVFVSIYVWLDESAKQKTKELPAQKSTVISE
SIO_010081: YGL057C
subclass of: SO_0000673
so part of: YGL057C
location: complement(394966..395829)
location: region:394966-395829:-1
so has part: feature:394966-395829:-1:exon

NP_011458.1
type: Protein
SIO_000068: ncbiprotein

S000003025
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394966-395829:-1:exon

YGL056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDS23
locus tag: YGL056C
so part of: sequence
location: complement(<396035..>397618)
location: region:396035-397618:-1
so has part: feature:396035-397618:-1:exon
subclass of: SO_0000010

852824
type: Gene
SIO_000068: ncbigene

position:396035:-1
position: 396035
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397618:-1
position: 397618
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:396035-397618:-1:exon

YGL056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDS23
locus tag: YGL056C
product: Sds23p
transcript id: NM_001180921.2
SIO_010081: YGL056C
subclass of: SO_0000673
so part of: YGL056C
location: complement(<396035..>397618)
location: region:396035-397618:-1
so has part: feature:396035-397618:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:396035-397618:-1:exon

YGL056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDS23
locus tag: YGL056C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]
experiment: EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16041152]
note: Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
codon start: 1
product: Sds23p
translation: MPQNTRHTSIVEMLSTPPQLPNSTDLNSLSEQTDKNTEANKSDTESLHKSISKSSSSSSLSTLDNTEYSNNNGNSLSTLNSQNLLSVHRQEWQHTPLSNLVEQNKLIFIRGSISVEEAFNTLVKHQLTSLPVENFPGDMNCLTFDYNDLNAYLLLVLNRIKVSNDKITSDCQNGKSVPVGEIVKLTPKNPFYKLPETENLSTVIGILGSGVHRVAITNVEMTQIKGILSQRRLIKYLWENARSFPNLKPLLDSSLEELNIGVLNAARDKPTFKQSRVISIQGDEHLIMALHKMYVERISSIAVVDPQGNLIGNISVTDVKHVTRTSQYPLLHNTCRHFVSVILNLRGLETGKDSFPIFHVYPTSSLARTFAKLVATKSHRLWIVQPNDNQPTASSEKSSSPSPSTPPVTTLPSLASSYHSNTQSSRMANSPVLKSSDTSNNKINVNINLSGPSPSQPQSPSATMPPPQSPSNCPASPTPAHFEKEYRTGKLIGVVSLTDILSVLARKQTHHKEIDPQMARKQRGHIG
SIO_010081: YGL056C
subclass of: SO_0000673
so part of: YGL056C
location: complement(396035..397618)
location: region:396035-397618:-1
so has part: feature:396035-397618:-1:exon

NP_011459.2
type: Protein
SIO_000068: ncbiprotein

S000003024
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:396035-397618:-1:exon

YGL055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MDM2
gene: OLE1
locus tag: YGL055W
gene synonym: MDM2
so part of: sequence
location: <398628..>400160
location: region:398628-400160:1
so has part: feature:398628-400160:1:exon
subclass of: SO_0000010

852825
type: Gene
SIO_000068: ncbigene

position:398628:1
position: 398628
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400160:1
position: 400160
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:398628-400160:1:exon

YGL055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MDM2
gene: OLE1
locus tag: YGL055W
gene synonym: MDM2
product: stearoyl-CoA 9-desaturase
transcript id: NM_001180920.3
SIO_010081: YGL055W
subclass of: SO_0000673
so part of: YGL055W
location: <398628..>400160
location: region:398628-400160:1
so has part: feature:398628-400160:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:398628-400160:1:exon

YGL055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MDM2
gene: OLE1
locus tag: YGL055W
gene synonym: MDM2
EC number: 1.14.19.1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12475963]
experiment: EXISTENCE:direct assay:GO:0045471 response to ethanol [PMID:31540996]
experiment: EXISTENCE:genetic interaction:GO:0009055 electron transfer activity [PMID:8530368]
experiment: EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:2202739]
experiment: EXISTENCE:mutant phenotype:GO:0004768 stearoyl-CoA 9-desaturase activity [PMID:1978720]
experiment: EXISTENCE:mutant phenotype:GO:0006636 unsaturated fatty acid biosynthetic process [PMID:1978720]
note: Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
codon start: 1
product: stearoyl-CoA 9-desaturase
translation: MPTSGTTIELIDDQFPKDDSASSGIVDEVDLTEANILATGLNKKAPRIVNGFGSLMGSKEMVSVEFDKKGNEKKSNLDRLLEKDNQEKEEAKTKIHISEQPWTLNNWHQHLNWLNMVLVCGMPMIGWYFALSGKVPLHLNVFLFSVFYYAVGGVSITAGYHRLWSHRSYSAHWPLRLFYAIFGCASVEGSAKWWGHSHRIHHRYTDTLRDPYDARRGLWYSHMGWMLLKPNPKYKARADITDMTDDWTIRFQHRHYILLMLLTAFVIPTLICGYFFNDYMGGLIYAGFIRVFVIQQATFCINSLAHYIGTQPFDDRRTPRDNWITAIVTFGEGYHNFHHEFPTDYRNAIKWYQYDPTKVIIYLTSLVGLAYDLKKFSQNAIEEALIQQEQKKINKKKAKINWGPVLTDLPMWDKQTFLAKSKENKGLVIISGIVHDVSGYISEHPGGETLIKTALGKDATKAFSGGVYRHSNAAQNVLADMRVAVIKESKNSAIRMASKRGEIYETGKFF
SIO_010081: YGL055W
subclass of: SO_0000673
so part of: YGL055W
location: 398628..400160
location: region:398628-400160:1
so has part: feature:398628-400160:1:exon

NP_011460.3
type: Protein
SIO_000068: ncbiprotein

S000003023
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:398628-400160:1:exon

YGL054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERV14
locus tag: YGL054C
so part of: sequence
location: complement(<400871..>401287)
location: region:400871-401287:-1
so has part: feature:400871-401287:-1:exon
subclass of: SO_0000010

852826
type: Gene
SIO_000068: ncbigene

position:400871:-1
position: 400871
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:401287:-1
position: 401287
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:400871-401287:-1:exon

YGL054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERV14
locus tag: YGL054C
product: cornichon family protein
transcript id: NM_001180919.1
SIO_010081: YGL054C
subclass of: SO_0000673
so part of: YGL054C
location: complement(<400871..>401287)
location: region:400871-401287:-1
so has part: feature:400871-401287:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:400871-401287:-1:exon

YGL054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERV14
locus tag: YGL054C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9732282]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]
experiment: EXISTENCE:direct assay:GO:0038024 cargo receptor activity [PMID:23270647]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9732282]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:9732282]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9732282]
experiment: EXISTENCE:mutant phenotype:GO:0038024 cargo receptor activity [PMID:23270647]
note: COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication
codon start: 1
product: cornichon family protein
translation: MGAWLFILAVVVNCINLFGQVHFTILYADLEADYINPIELCSKVNKLITPEAALHGALSLLFLLNGYWFVFLLNLPVLAYNLNKIYNKVQLLDATEIFRTLGKHKRESFLKLGFHLLMFFFYLYRMIMALIAESGDDF
SIO_010081: YGL054C
subclass of: SO_0000673
so part of: YGL054C
location: complement(400871..401287)
location: region:400871-401287:-1
so has part: feature:400871-401287:-1:exon

NP_011461.1
type: Protein
SIO_000068: ncbiprotein

S000003022
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:400871-401287:-1:exon

YNCG0016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0016C
so part of: sequence
location: complement(401527..401598)
location: region:401527-401598:-1
so has part: feature:401527-401598:-1:exon
subclass of: SO_0000663

852827
type: Gene
SIO_000068: ncbigene

position:401527:-1
position: 401527
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:401598:-1
position: 401598
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401527-401598:-1:exon

YNCG0016C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0016C
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCG0016C
subclass of: SO_0000673
so part of: YNCG0016C
location: complement(401527..401598)
location: region:401527-401598:-1
so has part: feature:401527-401598:-1:exon

S000006554
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401527-401598:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 401616..401894
location: region:401616-401894:1
so has part: feature:401616-401894:1:region

S000006949
type: SGD
SIO_000068: sgd

position:401616:1
position: 401616
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:401894:1
position: 401894
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401616-401894:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 401959..402290
location: region:401959-402290:1
so has part: feature:401959-402290:1:region

S000006944
type: SGD
SIO_000068: sgd

position:401959:1
position: 401959
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:402290:1
position: 402290
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401959-402290:1:region

YGL053W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRM8
locus tag: YGL053W
so part of: sequence
location: <402589..>403302
location: region:402589-403302:1
so has part: feature:402589-403302:1:exon
subclass of: SO_0000010

852828
type: Gene
SIO_000068: ncbigene

position:402589:1
position: 402589
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:403302:1
position: 403302
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402589-403302:1:exon

YGL053W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRM8
locus tag: YGL053W
product: pheromone-regulated DUP240 family protein PRM8
transcript id: NM_001180918.1
SIO_010081: YGL053W
subclass of: SO_0000673
so part of: YGL053W
location: <402589..>403302
location: region:402589-403302:1
so has part: feature:402589-403302:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402589-403302:1:exon

YGL053W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRM8
locus tag: YGL053W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12925749]
experiment: EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:12101299]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]
note: Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication
codon start: 1
product: pheromone-regulated DUP240 family protein PRM8
translation: MQTPSENTNAKSDSLDEPGAYLIEENVALPKDIFHSYLSYWIYEAAHCTPVMLLSLVIGVLISIIILFHDNENCVGVSVGFLLIFSGILVIVLILRFGPQISDEDFKCKLLMEIITRKPTVKGKEWRTITYKMNQYLFDNDLWNTPYYFYRDEDCHRYFLSLIKGRTFKKQKESSASNVKDAQSNDETAGTPNEAAESSSFSAGPNFIKLLTKAAEIEQQFQKEYWRQEYPGVDEFF
SIO_010081: YGL053W
subclass of: SO_0000673
so part of: YGL053W
location: 402589..403302
location: region:402589-403302:1
so has part: feature:402589-403302:1:exon

NP_011462.1
type: Protein
SIO_000068: ncbiprotein

S000003021
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402589-403302:1:exon

YGL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MST27
locus tag: YGL051W
so part of: sequence
location: <403687..>404391
location: region:403687-404391:1
so has part: feature:403687-404391:1:exon
subclass of: SO_0000010

852830
type: Gene
SIO_000068: ncbigene

position:403687:1
position: 403687
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:404391:1
position: 404391
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:403687-404391:1:exon

YGL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MST27
locus tag: YGL051W
product: DUP240 family protein MST27
transcript id: NM_001180916.1
SIO_010081: YGL051W
subclass of: SO_0000673
so part of: YGL051W
location: <403687..>404391
location: region:403687-404391:1
so has part: feature:403687-404391:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:403687-404391:1:exon

YGL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MST27
locus tag: YGL051W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12925749|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12925749]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:12925749]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12925749]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12925749]
experiment: EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:12101299]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]
note: Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog, MST28, that arose from a segmental duplication
codon start: 1
product: DUP240 family protein MST27
translation: MQTPLESTDVKLDTLNEPSAHLIEKNVALPKDIFRSYLSYWIYEIARYTPVMILSLVIGVLVLLIIFFNDNEACVFNSAYYAYLSLVVLLIILGDGNPKLVSRRNFRTELLVDVITRKPAVEGKEWRIITYNMNQYLFNHGQWHTPYYFYSDEDCYRYFLRLVEGVTPKKQTATSIGNSPVTAKPEDAIESASPSSRLNYRNFLLKAAEIERQAQENYWRRRHPNIDALLKKTE
SIO_010081: YGL051W
subclass of: SO_0000673
so part of: YGL051W
location: 403687..404391
location: region:403687-404391:1
so has part: feature:403687-404391:1:exon

NP_011464.1
type: Protein
SIO_000068: ncbiprotein

S000003019
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:403687-404391:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 405004..405145
location: region:405004-405145:1
so has part: feature:405004-405145:1:region

S000006945
type: SGD
SIO_000068: sgd

position:405004:1
position: 405004
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:405145:1
position: 405145
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405004-405145:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 405146..405207
location: region:405146-405207:1
so has part: feature:405146-405207:1:region

S000006946
type: SGD
SIO_000068: sgd

position:405146:1
position: 405146
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:405207:1
position: 405207
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405146-405207:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(405208..405453)
location: region:405208-405453:-1
so has part: feature:405208-405453:-1:region

S000006938
type: SGD
SIO_000068: sgd

position:405208:-1
position: 405208
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:405453:-1
position: 405453
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405208-405453:-1:region

YNCG0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0017W
so part of: sequence
location: 405470..405541
location: region:405470-405541:1
so has part: feature:405470-405541:1:exon
subclass of: SO_0000663

852831
type: Gene
SIO_000068: ncbigene

position:405470:1
position: 405470
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:405541:1
position: 405541
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405470-405541:1:exon

YNCG0017W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0017W
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCG0017W
subclass of: SO_0000673
so part of: YNCG0017W
location: 405470..405541
location: region:405470-405541:1
so has part: feature:405470-405541:1:exon

S000006711
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:405470-405541:1:exon

YGL050W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TYW3
locus tag: YGL050W
so part of: sequence
location: <405776..>406597
location: region:405776-406597:1
so has part: feature:405776-406597:1:exon
subclass of: SO_0000010

852832
type: Gene
SIO_000068: ncbigene

position:405776:1
position: 405776
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:406597:1
position: 406597
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:405776-406597:1:exon

YGL050W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TYW3
locus tag: YGL050W
product: tRNA methyltransferase TYW3
transcript id: NM_001180915.3
SIO_010081: YGL050W
subclass of: SO_0000673
so part of: YGL050W
location: <405776..>406597
location: region:405776-406597:1
so has part: feature:405776-406597:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:405776-406597:1:exon

YGL050W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TYW3
locus tag: YGL050W
EC number: 2.1.1.282
experiment: EXISTENCE:direct assay:GO:0008175 tRNA methyltransferase activity [PMID:16642040]
experiment: EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0008175 tRNA methyltransferase activity [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:16642040]
experiment: EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:16642040|PMID:17150819]
note: tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
codon start: 1
product: tRNA methyltransferase TYW3
translation: MAAQNAFEQKKRAILNEIDSTQPDLSPKGTIDELCLPIIDLINASADMVTTSSCSGRVSVFLEGTKSYNGEVKIGGKGQGGKWLYVTHDREKVIGWLDELKSKSEFSFELSGKEIPTEKVTGSIRYILYKYEPFILHVKCRDFQAASKLYNTAMSCGFRESGIGSNNLVAIRINIKLDVPLGYLDETSGTLKFFVTPEYVSVLDSLSLSKFDENTRKMQALYDRIEKELINCAPDVNSKVNITPIETKEERRERKKREGMERQRQLKSPQNVL
SIO_010081: YGL050W
subclass of: SO_0000673
so part of: YGL050W
location: 405776..406597
location: region:405776-406597:1
so has part: feature:405776-406597:1:exon

NP_011465.3
type: Protein
SIO_000068: ncbiprotein

S000003018
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:405776-406597:1:exon

YGL049C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIF4632
locus tag: YGL049C
so part of: sequence
location: complement(<406860..>409604)
location: region:406860-409604:-1
so has part: feature:406860-409604:-1:exon
subclass of: SO_0000010

852833
type: Gene
SIO_000068: ncbigene

position:406860:-1
position: 406860
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:409604:-1
position: 409604
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:406860-409604:-1:exon

YGL049C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIF4632
locus tag: YGL049C
product: translation initiation factor eIF4G
transcript id: NM_001180914.1
SIO_010081: YGL049C
subclass of: SO_0000673
so part of: YGL049C
location: complement(<406860..>409604)
location: region:406860-409604:-1
so has part: feature:406860-409604:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:406860-409604:-1:exon

YGL049C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIF4632
locus tag: YGL049C
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22851688|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:22851688]
experiment: EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:22851688]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:17908917|PMID:18981231|PMID:19470581|PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:12861028]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:22851688]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:22851688]
experiment: EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:8336723]
experiment: EXISTENCE:mutant phenotype:GO:0031369 translation initiation factor binding [PMID:22851688]
experiment: EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12861028]
experiment: EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22851688]
note: Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); proposed to stimulate the ATPase and helicase activities of eIF4A synergistically with eIF4G based on sequence similarity with Tif4631p; proposed to be required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; associated with Pab1p-mediated poly(A)-tail stimulated, translation
codon start: 1
product: translation initiation factor eIF4G
translation: MTDQRGPPPPHPQQANGYKKFPPHDNQYSGANNSQPNNHYNENLYSAREPHNNKQYQSKNGKYGTNKYNNRNNSQGNAQYYNNRFNNGYRLNNNDYNPAMLPGMQWPANYYAPQMYYIPQQMVPVASPPYTHQPLNTNPEPPSTPKTTKIEITTKTGERLNLKKFHEEKKASKGEEKNDGVEQKSKSGTPFEKEATPVLPANEAVKDTLTETSNEKSTSEAENTKRLFLEQVRLRKAAMERKKNGLISETEKKQETSNHDNTDTTKPNSVIESEPIKEAPKPTGEANEVVIDGKSGASVKTPQHVTGSVTKSVTFNEPENESSSQDVDELVKDDDTTEISDTTGGKTVNKSDDETINSVITTEENTVKETEPSTSDIEMPTVSQLLETLGKAQPISDIYEFAYPENVERPDIKYKKPSVKYTYGPTFLLQFKDKLKFRPDPAWVEAVSSKIVIPPHIARNKPKDSGRFGGDFRSPSMRGMDHTSSSRVSSKRRSKRMGDDRRSNRGYTSRKDREKAAEKAEEQAPKEEIAPLVPSANRWIPKSRVKKTEKKLAPDGKTELFDKEEVERKMKSLLNKLTLEMFDSISSEILDIANQSKWEDDGETLKIVIEQIFHKACDEPHWSSMYAQLCGKVVKDLDPNIKDKENEGKNGPKLVLHYLVARCHEEFEKGWADKLPAGEDGNPLEPEMMSDEYYIAAAAKRRGLGLVRFIGYLYCLNLLTGKMMFECFRRLMKDLNNDPSEETLESVIELLNTVGEQFEHDKFVTPQATLEGSVLLDNLFMLLQHIIDGGTISNRIKFKLIDVKELREIKHWNSAKKDAGPKTIQQIHQEEEQLRQKKNSQRSNSRFNNHNQSNSNRYSSNRRNMQNTQRDSFASTKTGSFRNNQRNARKVEEVSQAPRANMFDALMNNDGDSD
SIO_010081: YGL049C
subclass of: SO_0000673
so part of: YGL049C
location: complement(406860..409604)
location: region:406860-409604:-1
so has part: feature:406860-409604:-1:exon

NP_011466.1
type: Protein
SIO_000068: ncbiprotein

S000003017
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:406860-409604:-1:exon

YGL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CIM3
alternative label: CRL3
alternative label: SCB68
alternative label: SUG1
gene: RPT6
locus tag: YGL048C
gene synonym: CIM3; CRL3; SCB68; SUG1
so part of: sequence
location: complement(<410069..>411286)
location: region:410069-411286:-1
so has part: feature:410069-411286:-1:exon
subclass of: SO_0000010

852834
type: Gene
SIO_000068: ncbigene

position:410069:-1
position: 410069
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:411286:-1
position: 411286
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410069-411286:-1:exon

YGL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CIM3
alternative label: CRL3
alternative label: SCB68
alternative label: SUG1
gene: RPT6
locus tag: YGL048C
gene synonym: CIM3; CRL3; SCB68; SUG1
product: proteasome regulatory particle base subunit RPT6
transcript id: NM_001180913.1
SIO_010081: YGL048C
subclass of: SO_0000673
so part of: YGL048C
location: complement(<410069..>411286)
location: region:410069-411286:-1
so has part: feature:410069-411286:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410069-411286:-1:exon

YGL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CIM3
alternative label: CRL3
alternative label: SCB68
alternative label: SUG1
gene: RPT6
locus tag: YGL048C
gene synonym: CIM3; CRL3; SCB68; SUG1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10419517]
experiment: EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:11742986|PMID:9741626]
experiment: EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:7870180]
experiment: EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]
experiment: EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:11410533]
experiment: EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:16269334]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:20855529]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:11389845]
experiment: EXISTENCE:mutant phenotype:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:17167105]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]
experiment: EXISTENCE:mutant phenotype:GO:0051091 positive regulation of DNA-binding transcription factor activity [PMID:16269334]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]
experiment: EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]
experiment: EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:10688918|PMID:12447385]
experiment: EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:10688918]
note: ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
codon start: 1
product: proteasome regulatory particle base subunit RPT6
translation: MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKDELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK
SIO_010081: YGL048C
subclass of: SO_0000673
so part of: YGL048C
location: complement(410069..411286)
location: region:410069-411286:-1
so has part: feature:410069-411286:-1:exon

NP_011467.1
type: Protein
SIO_000068: ncbiprotein

S000003016
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410069-411286:-1:exon

YGL047W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALG13
locus tag: YGL047W
so part of: sequence
location: <411552..>412160
location: region:411552-412160:1
so has part: feature:411552-412160:1:exon
subclass of: SO_0000010

852835
type: Gene
SIO_000068: ncbigene

position:411552:1
position: 411552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412160:1
position: 412160
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:411552-412160:1:exon

YGL047W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALG13
locus tag: YGL047W
product: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13
transcript id: NM_001180912.1
SIO_010081: YGL047W
subclass of: SO_0000673
so part of: YGL047W
location: <411552..>412160
location: region:411552-412160:1
so has part: feature:411552-412160:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:411552-412160:1:exon

YGL047W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALG13
locus tag: YGL047W
EC number: 2.4.1.141
experiment: EXISTENCE:direct assay:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:16100113]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16100110|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:16100113]
experiment: EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100113]
experiment: EXISTENCE:mutant phenotype:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:15615718|PMID:16100113]
experiment: EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:15615718|PMID:16100113]
experiment: EXISTENCE:physical interaction:GO:0043541 UDP-N-acetylglucosamine transferase complex [PMID:16100110|PMID:16100113]
note: Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant
codon start: 1
product: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13
translation: MGIIEEKALFVTCGATVPFPKLVSCVLSDEFCQELIQYGFVRLIIQFGRNYSSEFEHLVQERGGQRESQKIPIDQFGCGDTARQYVLMNGKLKVIGFDFSTKMQSIIRDYSDLVISHAGTGSILDSLRLNKPLIVCVNDSLMDNHQQQIADKFVELGYVWSCAPTETGLIAGLRASQTEKLKPFPVSHNPSFERLLVETIYS
SIO_010081: YGL047W
subclass of: SO_0000673
so part of: YGL047W
location: 411552..412160
location: region:411552-412160:1
so has part: feature:411552-412160:1:exon

NP_011468.1
type: Protein
SIO_000068: ncbiprotein

S000003015
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:411552-412160:1:exon

YNCG0018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0018C
so part of: sequence
location: complement(412294..412367)
location: region:412294-412367:-1
so has part: feature:412294-412367:-1:exon
subclass of: SO_0000663

852836
type: Gene
SIO_000068: ncbigene

position:412294:-1
position: 412294
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:412367:-1
position: 412367
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412294-412367:-1:exon

YNCG0018C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0018C
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0018C
subclass of: SO_0000673
so part of: YNCG0018C
location: complement(412294..412367)
location: region:412294-412367:-1
so has part: feature:412294-412367:-1:exon

S000006755
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:412294-412367:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 412456..412725
location: region:412456-412725:1
so has part: feature:412456-412725:1:region

S000006947
type: SGD
SIO_000068: sgd

position:412456:1
position: 412456
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:412725:1
position: 412725
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:412456-412725:1:region

YGL045W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ART9
alternative label: PAL3
alternative label: YGL046W
gene: RIM8
locus tag: YGL045W
gene synonym: ART9; PAL3; YGL046W
so part of: sequence
location: <414102..>415730
location: region:414102-415730:1
so has part: feature:414102-415730:1:exon
subclass of: SO_0000010

852837
type: Gene
SIO_000068: ncbigene

position:414102:1
position: 414102
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:415730:1
position: 415730
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:414102-415730:1:exon

YGL045W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ART9
alternative label: PAL3
alternative label: YGL046W
gene: RIM8
locus tag: YGL045W
gene synonym: ART9; PAL3; YGL046W
product: Rim8p
transcript id: NM_001180910.3
SIO_010081: YGL045W
subclass of: SO_0000673
so part of: YGL045W
location: <414102..>415730
location: region:414102-415730:1
so has part: feature:414102-415730:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:414102-415730:1:exon

YGL045W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ART9
alternative label: PAL3
alternative label: YGL046W
gene: RIM8
locus tag: YGL045W
gene synonym: ART9; PAL3; YGL046W
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:20028738]
experiment: EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:31658248]
note: Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
codon start: 1
product: Rim8p
translation: MSLLRLWNKESRAPSKIKSHGIVGSYGNSMLAHNNVKQFRIDIDEPHRVWKPNESITGEAVIDIKRDITNVAIKLSLVCEVRVKTGNSPTSKNKRIEKTLEKSTFLYGQDYVKTAFSAKEKKPHVDKTTILNGLSKGEHRFPFRIRIPRGRGMLSSIKFERGSITYFLSCTLESLNNINGLKKPEARCEREFAVIVPLDVSRLPKPKTKTVVLQSASMVQNKKNKSTEDESSSYTQLTQKSTTSNSSSSSVNSKTSPLPNKTVTISVDIPQAGFMIGEIIPIDVKIDHYKPFYAPAGLTTTLVRICRVGGAGKDDPMETFRKDICQSISPIYINPETLQFQSRVYLKVPLDAFSTLTTVGKFFSFQYYIEVMVNLSKKNVVYTESNRIIGTPIGEQNGLGVENNINRIQRKMLRMVNPETLENDSEGYESSIFFKDMVNVEKLKRLRNVTGMSIETVIGTTRSEQQQSDASIPSQSSITAPQNSPSNLRDWLAPLNAYDSDDVPVPKYSPNDKVSVPSEDKQELEQKRLQQLESDPPPCDDY
SIO_010081: YGL045W
subclass of: SO_0000673
so part of: YGL045W
location: 414102..415730
location: region:414102-415730:1
so has part: feature:414102-415730:1:exon

NP_011470.4
type: Protein
SIO_000068: ncbiprotein

S000003013
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:414102-415730:1:exon

YGL044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RNA15
locus tag: YGL044C
so part of: sequence
location: complement(<416146..>417036)
location: region:416146-417036:-1
so has part: feature:416146-417036:-1:exon
subclass of: SO_0000010

852838
type: Gene
SIO_000068: ncbigene

position:416146:-1
position: 416146
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:417036:-1
position: 417036
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:416146-417036:-1:exon

YGL044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RNA15
locus tag: YGL044C
product: Rna15p
transcript id: NM_001180909.1
SIO_010081: YGL044C
subclass of: SO_0000673
so part of: YGL044C
location: complement(<416146..>417036)
location: region:416146-417036:-1
so has part: feature:416146-417036:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:416146-417036:-1:exon

YGL044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RNA15
locus tag: YGL044C
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17684230]
experiment: EXISTENCE:direct assay:GO:0006378 mRNA polyadenylation [PMID:11344258]
experiment: EXISTENCE:direct assay:GO:0098789 pre-mRNA cleavage required for polyadenylation [PMID:11344258]
experiment: EXISTENCE:mutant phenotype:GO:0072423 response to DNA damage checkpoint signaling [PMID:24603480]
experiment: EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]
note: Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability
codon start: 1
product: Rna15p
translation: MNRQSGVNAGVQNNPPSRVVYLGSIPYDQTEEQILDLCSNVGPVINLKMMFDPQTGRSKGYAFIEFRDLESSASAVRNLNGYQLGSRFLKCGYSSNSDISGVSQQQQQQYNNINGNNNNNGNNNNNSNGPDFQNSGNANFLSQKFPELPSGIDVNINMTTPAMMISSELAKKPKEVQLKFLQKFQEWTRAHPEDAVSLLELCPQLSFVTAELLLTNGICKVDDLIPLASRPQEEASATNNNSVNEVVDPAVLNKQKELLKQVLQLNDSQISILPDDERMAIWDLKQKALRGEFGAF
SIO_010081: YGL044C
subclass of: SO_0000673
so part of: YGL044C
location: complement(416146..417036)
location: region:416146-417036:-1
so has part: feature:416146-417036:-1:exon

NP_011471.1
type: Protein
SIO_000068: ncbiprotein

S000003012
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:416146-417036:-1:exon

YGL043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PPR2
gene: DST1
locus tag: YGL043W
gene synonym: PPR2
so part of: sequence
location: <417483..>418412
location: region:417483-418412:1
so has part: feature:417483-418412:1:exon
subclass of: SO_0000010

852839
type: Gene
SIO_000068: ncbigene

position:417483:1
position: 417483
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:418412:1
position: 418412
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417483-418412:1:exon

YGL043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PPR2
gene: DST1
locus tag: YGL043W
gene synonym: PPR2
product: transcription elongation factor DST1
transcript id: NM_001180908.1
SIO_010081: YGL043W
subclass of: SO_0000673
so part of: YGL043W
location: <417483..>418412
location: region:417483-418412:1
so has part: feature:417483-418412:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417483-418412:1:exon

YGL043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PPR2
gene: DST1
locus tag: YGL043W
gene synonym: PPR2
experiment: EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:15767671]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9334234]
experiment: EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:7002153]
experiment: EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:17901206]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:7002153|PMID:7020755|PMID:8288647|PMID:9334234]
experiment: EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:18628399]
experiment: EXISTENCE:direct assay:GO:0031564 transcription antitermination [PMID:8636112|PMID:9037112|PMID:9169440]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:8876173]
experiment: EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17913884]
experiment: EXISTENCE:genetic interaction:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:17535246]
experiment: EXISTENCE:genetic interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:17901206]
experiment: EXISTENCE:genetic interaction:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]
experiment: EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:15767671]
experiment: EXISTENCE:mutant phenotype:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:14531857|PMID:16492753]
experiment: EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:15767671|PMID:17901206]
experiment: EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:8288647]
experiment: EXISTENCE:mutant phenotype:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]
experiment: EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:18628399]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17913884]
experiment: EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:6985606|PMID:8876173]
note: General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
codon start: 1
product: transcription elongation factor DST1
translation: MDSKEVLVHVKNLEKNKSNDAAVLEILHVLDKEFVPTEKLLRETKVGVEVNKFKKSTNVEISKLVKKMISSWKDAINKNKRSRQAQQHHQDHAPGNAEDKTTVGESVNGVQQPASSQSDAMKQDKYVSTKPRNSKNDGVDTAIYHHKLRDQVLKALYDVLAKESEHPPQSILHTAKAIESEMNKVNNCDTNEAAYKARYRIIYSNVISKNNPDLKHKIANGDITPEFLATCDAKDLAPAPLKQKIEEIAKQNLYNAQGATIERSVTDRFTCGKCKEKKVSYYQLQTRSADEPLTTFCTCEACGNRWKFS
SIO_010081: YGL043W
subclass of: SO_0000673
so part of: YGL043W
location: 417483..418412
location: region:417483-418412:1
so has part: feature:417483-418412:1:exon

NP_011472.1
type: Protein
SIO_000068: ncbiprotein

S000003011
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417483-418412:1:exon

YGL041C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL041C-B
so part of: sequence
location: complement(<418704..>418886)
location: region:418704-418886:-1
so has part: feature:418704-418886:-1:exon
subclass of: SO_0000010

1466454
type: Gene
SIO_000068: ncbigene

position:418704:-1
position: 418704
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:418886:-1
position: 418886
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:418704-418886:-1:exon

YGL041C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL041C-B
product: uncharacterized protein
transcript id: NM_001184550.1
SIO_010081: YGL041C-B
subclass of: SO_0000673
so part of: YGL041C-B
location: complement(<418704..>418886)
location: region:418704-418886:-1
so has part: feature:418704-418886:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:418704-418886:-1:exon

YGL041C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL041C-B
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum
codon start: 1
product: uncharacterized protein
translation: MFDSSIERVTLELCFHITLSIMCGCSIYFLLLVFILTFYSSVLLHLKLYFFSSDRAIFNA
SIO_010081: YGL041C-B
subclass of: SO_0000673
so part of: YGL041C-B
location: complement(418704..418886)
location: region:418704-418886:-1
so has part: feature:418704-418886:-1:exon

NP_878074.1
type: Protein
SIO_000068: ncbiprotein

S000028548
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:418704-418886:-1:exon

YGL041W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPC13
locus tag: YGL041W-A
so part of: sequence
location: <418825..>419289
location: region:418825-419289:1
so has part: feature:418825-419289:1:exon
subclass of: SO_0000010

5814844
type: Gene
SIO_000068: ncbigene

position:418825:1
position: 418825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:419289:1
position: 419289
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:418825-419289:1:exon

YGL041W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPC13
locus tag: YGL041W-A
product: Dpc13p
transcript id: NM_001184647.4
SIO_010081: YGL041W-A
subclass of: SO_0000673
so part of: YGL041W-A
location: <418825..>419289
location: region:418825-419289:1
so has part: feature:418825-419289:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:418825-419289:1:exon

YGL041W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPC13
locus tag: YGL041W-A
note: Putative mitochondrial hypothetical protein; conserved in fungi; identified by expression profiling and mass spectrometry
codon start: 1
product: Dpc13p
translation: MLRVIWKHSSRVTRSIELSNISTTNHTRSLRRLSWISPRRFYAQSWDDRQPNDKIDAHIKVQKLMDQINSRPNVLEKLEKVSNIMIEKKLVNLDGTSANEENTMKPWQMIKILMDRDLRHAMKEFKLELEKSGIQLGPEQLAPLMTVLGLEKKK
SIO_010081: YGL041W-A
subclass of: SO_0000673
so part of: YGL041W-A
location: 418825..419289
location: region:418825-419289:1
so has part: feature:418825-419289:1:exon

NP_001106172.4
type: Protein
SIO_000068: ncbiprotein

S000028826
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:418825-419289:1:exon

YGL040C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OLE4
alternative label: SLU1
gene: HEM2
locus tag: YGL040C
gene synonym: OLE4; SLU1
so part of: sequence
location: complement(<419527..>420555)
location: region:419527-420555:-1
so has part: feature:419527-420555:-1:exon
subclass of: SO_0000010

852842
type: Gene
SIO_000068: ncbigene

position:419527:-1
position: 419527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420555:-1
position: 420555
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:419527-420555:-1:exon

YGL040C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OLE4
alternative label: SLU1
gene: HEM2
locus tag: YGL040C
gene synonym: OLE4; SLU1
product: porphobilinogen synthase HEM2
transcript id: NM_001180905.1
SIO_010081: YGL040C
subclass of: SO_0000673
so part of: YGL040C
location: complement(<419527..>420555)
location: region:419527-420555:-1
so has part: feature:419527-420555:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:419527-420555:-1:exon

YGL040C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OLE4
alternative label: SLU1
gene: HEM2
locus tag: YGL040C
gene synonym: OLE4; SLU1
EC number: 4.2.1.24
experiment: EXISTENCE:direct assay:GO:0004655 porphobilinogen synthase activity [PMID:2204246]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:8973546]
experiment: EXISTENCE:mutant phenotype:GO:0004655 porphobilinogen synthase activity [PMID:2445751|PMID:323256]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:14559249|PMID:323256]
note: Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant
codon start: 1
product: porphobilinogen synthase HEM2
translation: MHTAEFLETEPTEISSVLAGGYNHPLLRQWQSERQLTKNMLIFPLFISDNPDDFTEIDSLPNINRIGVNRLKDYLKPLVAKGLRSVILFGVPLIPGTKDPVGTAADDPAGPVIQGIKFIREYFPELYIICDVCLCEYTSHGHCGVLYDDGTINRERSVSRLAAVAVNYAKAGAHCVAPSDMIDGRIRDIKRGLINANLAHKTFVLSYAAKFSGNLYGPFRDAACSAPSNGDRKCYQLPPAGRGLARRALERDMSEGADGIIVKPSTFYLDIMRDASEICKDLPICAYHVSGEYAMLHAAAEKGVVDLKTIAFESHQGFLRAGARLIITYLAPEFLDWLDEEN
SIO_010081: YGL040C
subclass of: SO_0000673
so part of: YGL040C
location: complement(419527..420555)
location: region:419527-420555:-1
so has part: feature:419527-420555:-1:exon

NP_011475.1
type: Protein
SIO_000068: ncbiprotein

S000003008
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:419527-420555:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS718; Autonomously Replicating Sequence
so part of: sequence
location: 421171..421279
location: region:421171-421279:1
so has part: feature:421171-421279:1:region

S000118458
type: SGD
SIO_000068: sgd

position:421171:1
position: 421171
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:421279:1
position: 421279
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:421171-421279:1:region

YNCG0019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUP54
locus tag: YNCG0019W
so part of: sequence
location: 423092..423205
location: region:423092-423205:1
so has part: feature:423092-423205:1:exon
subclass of: SO_0000663

852843
type: Gene
SIO_000068: ncbigene

position:423092:1
position: 423092
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:423205:1
position: 423205
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423092-423205:1:exon

YNCG0019W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUP54
locus tag: YNCG0019W
product: tRNA-Leu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Leucine tRNA (tRNA-Leu), predicted by tRNAscan-SE analysis; can mutate to suppress amber nonsense mutations
SIO_010081: YNCG0019W
subclass of: SO_0000673
so part of: YNCG0019W
location: join(423092..423129,423162..423205)
location: region:423092-423205:1
so has part: feature:423092-423129:1:exon
so has part: feature:423162-423205:1:exon

S000006640
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423092-423129:1:exon

position:423129:1
position: 423129
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:423162-423205:1:exon

position:423162:1
position: 423162
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL039W
so part of: sequence
location: <423961..>425007
location: region:423961-425007:1
so has part: feature:423961-425007:1:exon
subclass of: SO_0000010

852844
type: Gene
SIO_000068: ncbigene

position:423961:1
position: 423961
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:425007:1
position: 425007
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423961-425007:1:exon

YGL039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL039W
product: carbonyl reductase (NADPH-dependent)
transcript id: NM_001180904.1
SIO_010081: YGL039W
subclass of: SO_0000673
so part of: YGL039W
location: <423961..>425007
location: region:423961-425007:1
so has part: feature:423961-425007:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:423961-425007:1:exon

YGL039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL039W
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:25656103]
experiment: EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:18630881|PMID:19016485]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006725 cellular aromatic compound metabolic process [PMID:16268655]
experiment: EXISTENCE:direct assay:GO:0016614 oxidoreductase activity, acting on CH-OH group of donors [PMID:14574691|PMID:16268655]
experiment: EXISTENCE:direct assay:GO:0042180 cellular ketone metabolic process [PMID:14574691|PMID:16268655]
experiment: EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656103]
note: Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols
codon start: 1
product: carbonyl reductase (NADPH-dependent)
translation: MTTEKTVVFVSGATGFIALHVVDDLLKTGYKVIGSGRSQEKNDGLLKKFKSNPNLSMEIVEDIAAPNAFDKVFQKHGKEIKVVLHIASPVHFNTTDFEKDLLIPAVNGTKSILEAIKNYAADTVEKVVITSSVAALASPGDMKDTSFVVNEESWNKDTWESCQANAVSAYCGSKKFAEKTAWDFLEENQSSIKFTLSTINPGFVFGPQLFADSLRNGINSSSAIIANLVSYKLGDNFYNYSGPFIDVRDVSKAHLLAFEKPECAGQRLFLCEDMFCSQEALDILNEEFPQLKGKIATGEPGSGSTFLTKNCCKCDNRKTKNLLGFQFNKFRDCIVDTASQLLEVQSKS
SIO_010081: YGL039W
subclass of: SO_0000673
so part of: YGL039W
location: 423961..425007
location: region:423961-425007:1
so has part: feature:423961-425007:1:exon

NP_011476.1
type: Protein
SIO_000068: ncbiprotein

S000003007
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423961-425007:1:exon

YGL038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: LDB12
alternative label: NGD29
gene: OCH1
locus tag: YGL038C
gene synonym: LDB12; NGD29
so part of: sequence
location: complement(<425362..>426804)
location: region:425362-426804:-1
so has part: feature:425362-426804:-1:exon
subclass of: SO_0000010

852845
type: Gene
SIO_000068: ncbigene

position:425362:-1
position: 425362
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:426804:-1
position: 426804
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:425362-426804:-1:exon

YGL038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: LDB12
alternative label: NGD29
gene: OCH1
locus tag: YGL038C
gene synonym: LDB12; NGD29
product: initiation-specific alpha-1,6-mannosyltransferase
transcript id: NM_001180903.1
SIO_010081: YGL038C
subclass of: SO_0000673
so part of: YGL038C
location: complement(<425362..>426804)
location: region:425362-426804:-1
so has part: feature:425362-426804:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:425362-426804:-1:exon

YGL038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: LDB12
alternative label: NGD29
gene: OCH1
locus tag: YGL038C
gene synonym: LDB12; NGD29
EC number: 2.4.1.232
experiment: EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:17042779|PMID:9276464]
experiment: EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:10189369|PMID:1628616]
experiment: EXISTENCE:mutant phenotype:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:8253757]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:7649302]
note: Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
codon start: 1
product: initiation-specific alpha-1,6-mannosyltransferase
translation: MSRKLSHLIATRKSKTIVVTVLLIYSLLTFHLSNKRLLSQFYPSKDDFKQTLLPTTSHSQDINLKKQITVNKKKNQLHNLRDQLSFAFPYDSQAPIPQRVWQTWKVGADDKNFPSSFRTYQKTWSGSYSPDYQYSLISDDSIIPFLENLYAPVPIVIQAFKLMPGNILKADFLRYLLLFARGGIYSDMDTMLLKPIDSWPSQNKSWLNNIIDLNKPIPYKNSKPSLLSSDEISHQPGLVIGIEADPDRDDWSEWYARRIQFCQWTIQAKPGHPILRELILNITATTLASVQNPGVPVSEMIDPRFEEDYNVNYRHKRRHDETYKHSELKNNKNVDGSDIMNWTGPGIFSDIIFEYMNNVLRYNSDILLINPNLNKNDEEGSESATTPAKDVDNDTLSKSTRKFYKKISESLQSSNSMPWEFFSFLKEPVIVDDVMVLPITSFSPDVGQMGAQSSDDKMAFVKHMFSGSWKEDADKNAGHK
SIO_010081: YGL038C
subclass of: SO_0000673
so part of: YGL038C
location: complement(425362..426804)
location: region:425362-426804:-1
so has part: feature:425362-426804:-1:exon

NP_011477.1
type: Protein
SIO_000068: ncbiprotein

S000003006
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:425362-426804:-1:exon

YGL037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PNC1
locus tag: YGL037C
so part of: sequence
location: complement(<427297..>427947)
location: region:427297-427947:-1
so has part: feature:427297-427947:-1:exon
subclass of: SO_0000010

852846
type: Gene
SIO_000068: ncbigene

position:427297:-1
position: 427297
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:427947:-1
position: 427947
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:427297-427947:-1:exon

YGL037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PNC1
locus tag: YGL037C
product: nicotinamidase
transcript id: NM_001180902.3
SIO_010081: YGL037C
subclass of: SO_0000673
so part of: YGL037C
location: complement(<427297..>427947)
location: region:427297-427947:-1
so has part: feature:427297-427947:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:427297-427947:-1:exon

YGL037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PNC1
locus tag: YGL037C
EC number: 3.5.1.19
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12736687]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:12736687]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:12736687]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:11901108]
experiment: EXISTENCE:mutant phenotype:GO:0008936 nicotinamidase activity [PMID:19381334]
experiment: EXISTENCE:mutant phenotype:GO:0019358 nicotinate nucleotide salvage [PMID:11901108]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11901108]
experiment: EXISTENCE:mutant phenotype:GO:1904524 negative regulation of DNA amplification [PMID:26195783]
note: Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
codon start: 1
product: nicotinamidase
translation: MKTLIVVDMQNDFISPLGSLTVPKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHISFAKNHKDKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQVVTKHIKIVDKGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKATAISAAELGYKTTVLLDYTRPISDDPEVINKVKEELKAHNINVVDK
SIO_010081: YGL037C
subclass of: SO_0000673
so part of: YGL037C
location: complement(427297..427947)
location: region:427297-427947:-1
so has part: feature:427297-427947:-1:exon

NP_011478.3
type: Protein
SIO_000068: ncbiprotein

S000003005
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:427297-427947:-1:exon

YGL036W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL036W
so part of: sequence
location: <428601..>431330
location: region:428601-431330:1
so has part: feature:428601-431330:1:exon
subclass of: SO_0000010

852847
type: Gene
SIO_000068: ncbigene

position:428601:1
position: 428601
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:431330:1
position: 431330
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:428601-431330:1:exon

YGL036W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL036W
product: uncharacterized protein
transcript id: NM_001180901.1
SIO_010081: YGL036W
subclass of: SO_0000673
so part of: YGL036W
location: <428601..>431330
location: region:428601-431330:1
so has part: feature:428601-431330:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:428601-431330:1:exon

YGL036W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL036W
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MQKCAGHAPLVTAASRVSQDTVDALLQAILKAYHKLASIDSHINDPVEIAFKLINSFKYLPISGSSVKDFESELRELDVFSPLLQSAVTAANNSNIIWDLIAVLFAYISIHKQLHPLILHNLNIWKDFMADNDEETATTTDGDSMNFGVLSLLSIVQNFEEITPNLFEFLKLGLRSTLLKIWVAQWQRYDPSATNLINGDEKISSWITKDYQVDFFIITSLASTSSLEVLPSHYFVYKISKRISHFPNLIDPKLYRSAISTIMENGISDNGGGENSSDKIDPTDLSFHLQVLMEVIDHPELNYLQENRLILLLDIALNYLILVPTHCLHSNFGELGSTQSLASTLNIIQFLLSKFLINMGSISQLINQYNRKCITTNNINNNNINNNGVINGSTNTTSTTTTTITNNNNNSNNSSISNNNRKIDWTQSYQTRYQIPYWFEDSILPPIPPISKSLFTFDKNLDHESDSIMIVNDVLRCLNLTILLISKLLRDYDDLKINPLIQSSDDHSNEDNHVIIEQYMQLYLVPLFTSLLLAQQLKDRGQERDEGHKEKEENINLIGSSSVKKLFSQLIFFSSLKLCENLVIKEKNLALYHLIKFATKVSLDDLILQKISINLLNHLFFHQIRDGSDDDNLIKKLCLKNQLSFQALKDYITLWNDGSEVYNAFYKELFYEEQPKIKPIKLTTSDLLKLFPEDVQFVISTPPNTITSASTSDNCTSSQSAAQKNIENFTTLSKYDVYSSTSFIPSTSKNTNTNVSKQQQQPQNSTPCSSNRFLFNKSSLISQESNGSNNNSGTQGPGSMNESYSLDNSFNTTNTNMTRQPTTLTRATDAMTTAPTTPIPYKNTSGSSNNNLWIESPMTNFKGSTISKSTNKSKMVNTGKNYILGGHNKVKNNSRAQSIHIDDFENENN
SIO_010081: YGL036W
subclass of: SO_0000673
so part of: YGL036W
location: 428601..431330
location: region:428601-431330:1
so has part: feature:428601-431330:1:exon

NP_011479.1
type: Protein
SIO_000068: ncbiprotein

S000003004
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:428601-431330:1:exon

YGL035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CAT4
alternative label: SSN1
alternative label: TDS22
gene: MIG1
locus tag: YGL035C
gene synonym: CAT4; SSN1; TDS22
so part of: sequence
location: complement(<431548..>433062)
location: region:431548-433062:-1
so has part: feature:431548-433062:-1:exon
subclass of: SO_0000010

852848
type: Gene
SIO_000068: ncbigene

position:431548:-1
position: 431548
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433062:-1
position: 433062
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431548-433062:-1:exon

YGL035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CAT4
alternative label: SSN1
alternative label: TDS22
gene: MIG1
locus tag: YGL035C
gene synonym: CAT4; SSN1; TDS22
product: transcription factor MIG1
transcript id: NM_001180900.1
SIO_010081: YGL035C
subclass of: SO_0000673
so part of: YGL035C
location: complement(<431548..>433062)
location: region:431548-433062:-1
so has part: feature:431548-433062:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:431548-433062:-1:exon

YGL035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CAT4
alternative label: SSN1
alternative label: TDS22
gene: MIG1
locus tag: YGL035C
gene synonym: CAT4; SSN1; TDS22
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12239282|PMID:8114729|PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:7724528|PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17237508|PMID:9285828|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508|PMID:11914276|PMID:9285828]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0061987 negative regulation of transcription from RNA polymerase II promoter by glucose [PMID:7724528]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]
experiment: EXISTENCE:genetic interaction:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517|PMID:7724528]
experiment: EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]
experiment: EXISTENCE:mutant phenotype:GO:0000433 carbon catabolite repression of transcription from RNA polymerase II promoter by glucose [PMID:9832517]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]
note: Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state
codon start: 1
product: transcription factor MIG1
translation: MQSPYPMTQVSNVDDGSLLKESKSKSKVAAKSEAPRPHACPICHRAFHRLEHQTRHMRIHTGEKPHACDFPGCVKRFSRSDELTRHRRIHTNSHPRGKRGRKKKVVGSPINSASSSATSIPDLNTANFSPPLPQQHLSPLIPIAIAPKENSSRSSTRKGRKTKFEIGESGGNDPYMVSSPKTMAKIPVSVKPPPSLALNNMNYQTSSASTALSSLSNSHSGSRLKLNALSSLQMMTPIASSAPRTVFIDGPEQKQLQQQQNSLSPRYSNTVILPRPRSLTDFQGLNNANPNNNGSLRAQTQSSVQLKRPSSVLSLNDLLVGQRNTNESDSDFTTGGEDEEDGLKDPSNSSIDNLEQDYLQEQSRKKSKTSTPTTMLSRSTSGTNLHTLGYVMNQNHLHFSSSSPDFQKELNNRLLNVQQQQQEQHTLLQSQNTSNQSQNQNQNQMMASSSSLSTTPLLLSPRVNMINTAISTQQTPISQSDSQVQELETLPPIRSLPLPFPHMD
SIO_010081: YGL035C
subclass of: SO_0000673
so part of: YGL035C
location: complement(431548..433062)
location: region:431548-433062:-1
so has part: feature:431548-433062:-1:exon

NP_011480.1
type: Protein
SIO_000068: ncbiprotein

S000003003
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431548-433062:-1:exon

YGL034C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL034C
so part of: sequence
location: complement(<433214..>433579)
location: region:433214-433579:-1
so has part: feature:433214-433579:-1:exon
subclass of: SO_0000010

852849
type: Gene
SIO_000068: ncbigene

position:433214:-1
position: 433214
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433579:-1
position: 433579
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:433214-433579:-1:exon

YGL034C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL034C
product: uncharacterized protein
transcript id: NM_001348837.1
SIO_010081: YGL034C
subclass of: SO_0000673
so part of: YGL034C
location: complement(<433214..>433579)
location: region:433214-433579:-1
so has part: feature:433214-433579:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:433214-433579:-1:exon

YGL034C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL034C
note: hypothetical protein; conserved among S. cerevisiae strains; YGL034C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MNVVAIIMASQETCSGRAPRETPEWRRPACLVASILVRALEFSWLFSTCLLVAFDFARDCGLPPHSGKTWSDGKGPAALSFGKTNTKEATTNFYNRLDEKSGEEQAEKRKENSRSWIIYLL
SIO_010081: YGL034C
subclass of: SO_0000673
so part of: YGL034C
location: complement(433214..433579)
location: region:433214-433579:-1
so has part: feature:433214-433579:-1:exon

NP_001335778.1
type: Protein
SIO_000068: ncbiprotein

S000003002
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:433214-433579:-1:exon

YGL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HOP2
locus tag: YGL033W
so part of: sequence
location: <435625..>436401
location: region:435625-436401:1
so has part: feature:435625-436401:1:exon
subclass of: SO_0000010

852850
type: Gene
SIO_000068: ncbigene

position:435625:1
position: 435625
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436401:1
position: 436401
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:435625-436401:1:exon

YGL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HOP2
locus tag: YGL033W
product: Hop2p
transcript id: NM_001180898.2
SIO_010081: YGL033W
subclass of: SO_0000673
so part of: YGL033W
location: join(<435625..435679,435750..436312,436375..>436401)
location: region:435625-436401:1
so has part: feature:435625-435679:1:exon
so has part: feature:435750-436312:1:exon
so has part: feature:436375-436401:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:435625-435679:1:exon

position:435679:1
position: 435679
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:435750-436312:1:exon

position:435750:1
position: 435750
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:436312:1
position: 436312
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 3
SIO_000628: feature:436375-436401:1:exon

position:436375:1
position: 436375
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HOP2
locus tag: YGL033W
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9708739]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15249670]
experiment: EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:9708739]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767]
note: Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion
codon start: 1
product: Hop2p
translation: MAPKKKSNDRAIQAKGSEAEQLIEDYLVSQYKPFSVNDIVQNLHNKVTKTTATKALENLVNEKRIVSKTFGKIIIYSCNEQDTALPSNIDPSQFDFETVLQLRNDLIELERDKSTAKDALDSVTKEPENEDLLTIIENEENELKKIESKLQSLQDDWDPANDEIVKRIMSEDTLLQKEITKRSKICKNLIATIKDSVCPKNMNEFLEEIGFEDI
SIO_010081: YGL033W
subclass of: SO_0000673
so part of: YGL033W
location: join(435625..435679,435750..436312,436375..436401)
location: region:435625-436401:1
so has part: feature:435625-435679:1:exon
so has part: feature:435750-436312:1:exon
so has part: feature:436375-436401:1:exon

NP_011482.3
type: Protein
SIO_000068: ncbiprotein

S000003001
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:435625-435679:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:435750-436312:1:exon

urn:…
SIO_000300: 3
SIO_000628: feature:436375-436401:1:exon

YGL032C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AGA2
locus tag: YGL032C
so part of: sequence
location: complement(<436570..>436833)
location: region:436570-436833:-1
so has part: feature:436570-436833:-1:exon
subclass of: SO_0000010

852851
type: Gene
SIO_000068: ncbigene

position:436570:-1
position: 436570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:436833:-1
position: 436833
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:436570-436833:-1:exon

YGL032C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AGA2
locus tag: YGL032C
product: Aga2p
transcript id: NM_001180897.3
SIO_010081: YGL032C
subclass of: SO_0000673
so part of: YGL032C
location: complement(<436570..>436833)
location: region:436570-436833:-1
so has part: feature:436570-436833:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:436570-436833:-1:exon

YGL032C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AGA2
locus tag: YGL032C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:1756718]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:1756718]
experiment: EXISTENCE:direct assay:GO:0050839 cell adhesion molecule binding [PMID:11292808|PMID:7957044]
note: Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
codon start: 1
product: Aga2p
translation: MQLLRCFSIFSVIASVLAQELTTICEQIPSPTLESTPYSLSTTTILANGKAMQGVFEYYKSVTFVSNCGSHPSTTSKGSPINTQYVF
SIO_010081: YGL032C
subclass of: SO_0000673
so part of: YGL032C
location: complement(436570..436833)
location: region:436570-436833:-1
so has part: feature:436570-436833:-1:exon

NP_011483.3
type: Protein
SIO_000068: ncbiprotein

S000003000
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:436570-436833:-1:exon

YGL031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPL30A
gene: RPL24A
locus tag: YGL031C
gene synonym: RPL30A
so part of: sequence
location: complement(<437467..>437934)
location: region:437467-437934:-1
so has part: feature:437467-437934:-1:exon
subclass of: SO_0000010

852852
type: Gene
SIO_000068: ncbigene

position:437467:-1
position: 437467
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437934:-1
position: 437934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437467-437934:-1:exon

YGL031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPL30A
gene: RPL24A
locus tag: YGL031C
gene synonym: RPL30A
product: ribosomal 60S subunit protein L24A
transcript id: NM_001180896.1
SIO_010081: YGL031C
subclass of: SO_0000673
so part of: YGL031C
location: complement(<437467..>437934)
location: region:437467-437934:-1
so has part: feature:437467-437934:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437467-437934:-1:exon

YGL031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPL30A
gene: RPL24A
locus tag: YGL031C
gene synonym: RPL30A
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:30407570]
experiment: EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:30407570]
note: Ribosomal 60S subunit protein L24A; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L24A
translation: MKVEIDSFSGAKIYPGRGTLFVRGDSKIFRFQNSKSASLFKQRKNPRRIAWTVLFRKHHKKGITEEVAKKRSRKTVKAQRPITGASLDLIKERRSLKPEVRKANREEKLKANKEKKKAEKAARKAEKAKSAGTQSSKFSKQQAKGAFQKVAATSR
SIO_010081: YGL031C
subclass of: SO_0000673
so part of: YGL031C
location: complement(437467..437934)
location: region:437467-437934:-1
so has part: feature:437467-437934:-1:exon

NP_011484.1
type: Protein
SIO_000068: ncbiprotein

S000002999
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437467-437934:-1:exon

YGL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL30
locus tag: YGL030W
so part of: sequence
location: <439091..>439638
location: region:439091-439638:1
so has part: feature:439091-439638:1:exon
subclass of: SO_0000010

852853
type: Gene
SIO_000068: ncbigene

position:439091:1
position: 439091
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:439638:1
position: 439638
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439091-439638:1:exon

YGL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL30
locus tag: YGL030W
product: ribosomal 60S subunit protein L30
transcript id: NM_001180895.1
SIO_010081: YGL030W
subclass of: SO_0000673
so part of: YGL030W
location: join(<439091..439093,439324..>439638)
location: region:439091-439638:1
so has part: feature:439091-439093:1:exon
so has part: feature:439324-439638:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439091-439093:1:exon

position:439093:1
position: 439093
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:439324-439638:1:exon

position:439324:1
position: 439324
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL30
locus tag: YGL030W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14970382]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9121443]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11142377]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]
experiment: EXISTENCE:genetic interaction:GO:0030627 pre-mRNA 5'-splice site binding [PMID:18570876]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9121443]
experiment: EXISTENCE:mutant phenotype:GO:0030627 pre-mRNA 5'-splice site binding [PMID:18570876]
experiment: EXISTENCE:mutant phenotype:GO:0048025 negative regulation of mRNA splicing, via spliceosome [PMID:9121443|PMID:18570876]
note: Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
codon start: 1
product: ribosomal 60S subunit protein L30
translation: MAPVKSQESINQKLALVIKSGKYTLGYKSTVKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSILEAGDSDILTTLA
SIO_010081: YGL030W
subclass of: SO_0000673
so part of: YGL030W
location: join(439091..439093,439324..439638)
location: region:439091-439638:1
so has part: feature:439091-439093:1:exon
so has part: feature:439324-439638:1:exon

NP_011485.1
type: Protein
SIO_000068: ncbiprotein

S000002998
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439091-439093:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:439324-439638:1:exon

YGL029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CGR1
locus tag: YGL029W
so part of: sequence
location: <440063..>440425
location: region:440063-440425:1
so has part: feature:440063-440425:1:exon
subclass of: SO_0000010

852854
type: Gene
SIO_000068: ncbigene

position:440063:1
position: 440063
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440425:1
position: 440425
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440063-440425:1:exon

YGL029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CGR1
locus tag: YGL029W
product: Cgr1p
transcript id: NM_001180894.1
SIO_010081: YGL029W
subclass of: SO_0000673
so part of: YGL029W
location: <440063..>440425
location: region:440063-440425:1
so has part: feature:440063-440425:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:440063-440425:1:exon

YGL029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CGR1
locus tag: YGL029W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11116400]
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:11932453]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:11116400]
note: Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress
codon start: 1
product: Cgr1p
translation: MVNETGESQKAAKGTPVSGKVWKAEKTPLRAKSRVVKNKKLTSWELKKQKRLEDKQFKERLKALKDEKEEARQAKITMLKERREKKEENERYERLAAKMHAKKVERMRRREKRNKALKER
SIO_010081: YGL029W
subclass of: SO_0000673
so part of: YGL029W
location: 440063..440425
location: region:440063-440425:1
so has part: feature:440063-440425:1:exon

NP_011486.1
type: Protein
SIO_000068: ncbiprotein

S000002997
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440063-440425:1:exon

YNCG0020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0020C
so part of: sequence
location: complement(440716..440807)
location: region:440716-440807:-1
so has part: feature:440716-440807:-1:exon
subclass of: SO_0000663

852855
type: Gene
SIO_000068: ncbigene

position:440716:-1
position: 440716
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:440807:-1
position: 440807
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:440716-440807:-1:exon

YNCG0020C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0020C
product: tRNA-Phe
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Phenylalanine tRNA (tRNA-Phe), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0020C
subclass of: SO_0000673
so part of: YNCG0020C
location: complement(join(440716..440751,440771..440807))
location: region:440716-440807:-1
so has part: feature:440771-440807:-1:exon
so has part: feature:440716-440751:-1:exon

S000006565
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:440771-440807:-1:exon

position:440771:-1
position: 440771
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:440716-440751:-1:exon

position:440751:-1
position: 440751
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGL028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCW11
locus tag: YGL028C
so part of: sequence
location: complement(<441281..>442909)
location: region:441281-442909:-1
so has part: feature:441281-442909:-1:exon
subclass of: SO_0000010

852856
type: Gene
SIO_000068: ncbigene

position:441281:-1
position: 441281
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:442909:-1
position: 442909
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441281-442909:-1:exon

YGL028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCW11
locus tag: YGL028C
product: putative glucan endo-1,3-beta-D-glucosidase
transcript id: NM_001180893.3
SIO_010081: YGL028C
subclass of: SO_0000673
so part of: YGL028C
location: complement(<441281..>442909)
location: region:441281-442909:-1
so has part: feature:441281-442909:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441281-442909:-1:exon

YGL028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCW11
locus tag: YGL028C
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9748433]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
codon start: 1
product: putative glucan endo-1,3-beta-D-glucosidase
translation: MISPISFLSSLLCLTYLTSALPILPKREVVTRVHTASTTNVVTDFYSTTTEVVIAPTVEFLISDSVTFTTTLIPQGVNPTAEPTTTITKVLLKKAEMSTSSQPTSTLQPSTIPQSTSSFQAESTLQAVSTQQTAMSVSAGTSEDVQQLATTSTSISSSPSPTTTSTSTQNIVSGVGEANVEGNTQSQHHSYQAAATSTLNQQTSTSIASQESTESTNTPTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSSTSSTQETAATTSEGSSSSSAAITSSPKAIAYSPYNDDGSCKSADAVSSDLTLIKSKGISKIRVYGTDCNSFETVQPAAVKLGIKINQGLYITSSGVDSIDDSVTTLIQYGQTNGWDVFDFITVGNEAINNGWCSVSDLISKISSVKSKLSEAGYSGQITTSEPPVSFENNPDLCKKSDIDFVGINPHAYFDTSASAETAGTFVKGQVELIQGVCGTSNVFVTETGYPSSGIQNGGNIPSTANQITAVQNILNEMDLDVTILSTYNDYWKAPGDYGIEQSFGVIEYFP
SIO_010081: YGL028C
subclass of: SO_0000673
so part of: YGL028C
location: complement(441281..442909)
location: region:441281-442909:-1
so has part: feature:441281-442909:-1:exon

NP_011487.3
type: Protein
SIO_000068: ncbiprotein

S000002996
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441281-442909:-1:exon

YGL027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DER7
alternative label: GLS1
gene: CWH41
locus tag: YGL027C
gene synonym: DER7; GLS1
so part of: sequence
location: complement(<443642..>446143)
location: region:443642-446143:-1
so has part: feature:443642-446143:-1:exon
subclass of: SO_0000010

852857
type: Gene
SIO_000068: ncbigene

position:443642:-1
position: 443642
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:446143:-1
position: 446143
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443642-446143:-1:exon

YGL027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DER7
alternative label: GLS1
gene: CWH41
locus tag: YGL027C
gene synonym: DER7; GLS1
product: mannosyl-oligosaccharide glucosidase
transcript id: NM_001180892.1
SIO_010081: YGL027C
subclass of: SO_0000673
so part of: YGL027C
location: complement(<443642..>446143)
location: region:443642-446143:-1
so has part: feature:443642-446143:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443642-446143:-1:exon

YGL027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DER7
alternative label: GLS1
gene: CWH41
locus tag: YGL027C
gene synonym: DER7; GLS1
EC number: 3.2.1.106
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [PMID:14680956]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8576053]
experiment: EXISTENCE:genetic interaction:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]
experiment: EXISTENCE:mutant phenotype:GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [PMID:9430631]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9363442]
experiment: EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:9430631]
note: Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
codon start: 1
product: mannosyl-oligosaccharide glucosidase
translation: MLISKSKMFKTFWILTSIVLLASATVDISKLQEFEEYQKFTNESLLWAPYRSNCYFGMRPRYVHESPLIMGIMWFNSLSQDGLHSLRHFATPQDKLQKYGWEVYDPRIGGKEVFIDEKNNLNLTVYFVKSKNGENWSVRVQGEPLDPKRPSTASVVLYFSQNGGEIDGKSSLAMIGHDGPNDMKFFGYSKELGEYHLTVKDNFGHYFKNPEYETMEVAPGSDCSKTSHLSLQIPDKEVWKARDVFQSLVSDSIRDILEKEETKQRPADLIPSVLTIRNLYNFNPGNFHYIQKTFDLTKKDGFQFDITYNKLGTTQSISTREQVTELITWSLNEINARFDKQFSFGEGPDSIESVEVKRRFALETLSNLLGGIGYFYGNQLIDRETEFDESQFTEIKLLNAKEEGPFELFTSVPSRGFFPRGFYWDEGFHLLQIMEYDFDLAFEILASWFEMIEDDSGWIAREIILGNEARSKVPQEFQVQNPNIANPPTLLLAFSEMLSRAIENIGDFNSDSYHQVMFNSRTAKFMTNNLEANPGLLTEYAKKIYPKLLKHYNWFRKSQTGLIDEYEEILEDEGIWDKIHKNEVYRWVGRTFTHCLPSGMDDYPRAQPPDVAELNVDALAWVGVMTRSMKQIAHVLKLTQDEQRYAQIEQEVVENLDLLHWSENDNCYCDISIDPEDDEIREFVCHEGYVSVLPFALKLIPKNSPKLEKVVALMSDPEKIFSDYGLLSLSRQDDYFGKDENYWRGPIWMNINYLCLDAMRYYYPEVILDVAGEASNAKKLYQSLKINLSNNIYKVWEEQGYCYENYSPIDGHGTGAEHFTGWTALVVNILGRF
SIO_010081: YGL027C
subclass of: SO_0000673
so part of: YGL027C
location: complement(443642..446143)
location: region:443642-446143:-1
so has part: feature:443642-446143:-1:exon

NP_011488.1
type: Protein
SIO_000068: ncbiprotein

S000002995
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443642-446143:-1:exon

YGL026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRP5
locus tag: YGL026C
so part of: sequence
location: complement(<446412..>448535)
location: region:446412-448535:-1
so has part: feature:446412-448535:-1:exon
subclass of: SO_0000010

852858
type: Gene
SIO_000068: ncbigene

position:446412:-1
position: 446412
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:448535:-1
position: 448535
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:446412-448535:-1:exon

YGL026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRP5
locus tag: YGL026C
product: tryptophan synthase TRP5
transcript id: NM_001180891.1
SIO_010081: YGL026C
subclass of: SO_0000673
so part of: YGL026C
location: complement(<446412..>448535)
location: region:446412-448535:-1
so has part: feature:446412-448535:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:446412-448535:-1:exon

YGL026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRP5
locus tag: YGL026C
EC number: 4.2.1.20
experiment: EXISTENCE:direct assay:GO:0004834 tryptophan synthase activity [PMID:391563|PMID:6342605]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000162 tryptophan biosynthetic process [PMID:10790693]
note: Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
codon start: 1
product: tryptophan synthase TRP5
translation: MSEQLRQTFANAKKENRNALVTFMTAGYPTVKDTVPILKGFQDGGVDIIELGMPFSDPIADGPTIQLSNTVALQNGVTLPQTLEMVSQARNEGVTVPIILMGYYNPILNYGEERFIQDAAKAGANGFIIVDLPPEEALKVRNYINDNGLSLIPLVAPSTTDERLELLSHIADSFVYVVSRMGTTGVQSSVASDLDELISRVRKYTKDTPLAVGFGVSTREHFQSVGSVADGVVIGSKIVTLCGDAPEGKRYDVAKEYVQGILNGAKHKVLSKDEFFAFQKESLKSANVKKEILDEFDENHKHPIRFGDFGGQYVPEALHACLRELEKGFDEAVADPTFWEDFKSLYSYIGRPSSLHKAERLTEHCQGAQIWLKREDLNHTGSHKINNALAQVLLAKRLGKKNVIAETGAGQHGVATATACAKFGLTCTVFMGAEDVRRQALNVFRMRILGAKVIAVTNGTKTLRDATSEAFRFWVTNLKTTYYVVGSAIGPHPYPTLVRTFQSVIGKETKEQFAAMNNGKLPDAVVACVGGGSNSTGMFSPFEHDTSVKLLGVEAGGDGVDTKFHSATLTAGRPGVFHGVKTYVLQDSDGQVHDTHSVSAGLDYPGVGPELAYWKSTGRAQFIAATDAQALLGFKLLSQLEGIIPALESSHAVYGACELAKTMKPDQHLVINISGRGDKDVQSVAEVLPKLGPKIGWDLRFEEDPSA
SIO_010081: YGL026C
subclass of: SO_0000673
so part of: YGL026C
location: complement(446412..448535)
location: region:446412-448535:-1
so has part: feature:446412-448535:-1:exon

NP_011489.1
type: Protein
SIO_000068: ncbiprotein

S000002994
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:446412-448535:-1:exon

YGL025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HRS1
alternative label: MED3
gene: PGD1
locus tag: YGL025C
gene synonym: HRS1; MED3
so part of: sequence
location: complement(<448764..>449957)
location: region:448764-449957:-1
so has part: feature:448764-449957:-1:exon
subclass of: SO_0000010

852860
type: Gene
SIO_000068: ncbigene

position:448764:-1
position: 448764
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449957:-1
position: 449957
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448764-449957:-1:exon

YGL025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HRS1
alternative label: MED3
gene: PGD1
locus tag: YGL025C
gene synonym: HRS1; MED3
product: Pgd1p
transcript id: NM_001180890.1
SIO_010081: YGL025C
subclass of: SO_0000673
so part of: YGL025C
location: complement(<448764..>449957)
location: region:448764-449957:-1
so has part: feature:448764-449957:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:448764-449957:-1:exon

YGL025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HRS1
alternative label: MED3
gene: PGD1
locus tag: YGL025C
gene synonym: HRS1; MED3
experiment: EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11073972]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10722672]
experiment: EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12558798]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10722672]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
codon start: 1
product: Pgd1p
translation: MDSIIPAGVKLDDLQVILAKNENETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEGSKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPLSTYNKNGNAVCSTATVVSTNHSAAASTPTTTATPHANPITHAHSLSNPNSTATMQHNPLAGKRGPKSGSTMGTPTVHNSTAAAPIAAPKKPRKPRQTKKAKAQAQAQAQAQAQVYAQQSTVQTPITASMAAALPNPTPSMINSVSPTNVMGTPLTNMMSPMGNAYSMGAQNQGGQVSMSQFNGSGNGSNPNTNTNSNNTPLQSQLNLNNLTPANILNMSMNNDFQQQQQQQQQQQQPQPQYNMNMGMNNMNNGGKELDSLDLNNLELGGLNMDFL
SIO_010081: YGL025C
subclass of: SO_0000673
so part of: YGL025C
location: complement(448764..449957)
location: region:448764-449957:-1
so has part: feature:448764-449957:-1:exon

NP_011490.2
type: Protein
SIO_000068: ncbiprotein

S000002993
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:448764-449957:-1:exon

YGL023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PIB2
locus tag: YGL023C
so part of: sequence
location: complement(<450197..>452104)
location: region:450197-452104:-1
so has part: feature:450197-452104:-1:exon
subclass of: SO_0000010

852861
type: Gene
SIO_000068: ncbigene

position:450197:-1
position: 450197
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:452104:-1
position: 452104
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450197-452104:-1:exon

YGL023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PIB2
locus tag: YGL023C
product: Pib2p
transcript id: NM_001180888.3
SIO_010081: YGL023C
subclass of: SO_0000673
so part of: YGL023C
location: complement(<450197..>452104)
location: region:450197-452104:-1
so has part: feature:450197-452104:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450197-452104:-1:exon

YGL023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PIB2
locus tag: YGL023C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:29698392]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:1904263 positive regulation of TORC1 signaling [PMID:34535752]
experiment: EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:29698392]
experiment: EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:29698392]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:34535752]
note: Phosphatidylinositol 3-phosphate binding protein; formation of a distinct complex with TORC1, induced by glutamine in dose-dependent manner, results in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1, a lysosomal membrane permeabilization regulator; contains a PtdIns3P binding FYVE domain; similar to Fab1p and Vps27p
codon start: 1
product: Pib2p
translation: MTALHSVSKTPAIKEEEEDGDERDGRGVPLGPRNHDYRGRKGDEESGADTVTSPITFEKKKIAPRASTHSEQSILSSISLKSMVNQHRQQQLQQESSTGAGTGFVDRKQQIQSPAMVSILRKNSAEENVRSSHSSKLGEGQIDGRKASASKEIGKTLPFTDDQRSNPELDPTNSVVDVSRGKNTKSKTVFNELEDDADDDDEVRQKNLTTQALRKLSSFKMNASSNLRLSKENKAKESSSSSTSSVSSSSTSKVENIVDKLTTTNSSSMSQLRFGNTNVIIDSVNHAAKPPHQQMLRKPSLEFLPQPASSTNLNFNSNKHKSNVRQISNPKKPLYIPAVLRKVSETNITNDDLLNATLSSYYKKASNLEHGFNPSKSQSASVQNANNLRIISSQSSVQSNTSSILESYKNKISSYLFPNSIPNSDRINLIPTISNRNSARVNPPTKDHWIPDSKRNSCRYCHKPFTLWERKHHCRHCGDIFCQDHLRHWLYLDSQANFIMINELNNGGINGGGTLCKICDDCLVEYENLSTTNHNANTNEDNINVEEGEDDDNDNRKKLRNYYKNRQMNALFRPKKGGSSQEHATVDRDTTTPIQVKSNDEEADNENTGGEQEEGNDVLGSVIGSVPANWNWSSF
SIO_010081: YGL023C
subclass of: SO_0000673
so part of: YGL023C
location: complement(450197..452104)
location: region:450197-452104:-1
so has part: feature:450197-452104:-1:exon

NP_011492.3
type: Protein
SIO_000068: ncbiprotein

S000002991
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450197-452104:-1:exon

YGL022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STT3
locus tag: YGL022W
so part of: sequence
location: <452404..>454560
location: region:452404-454560:1
so has part: feature:452404-454560:1:exon
subclass of: SO_0000010

852862
type: Gene
SIO_000068: ncbigene

position:452404:1
position: 452404
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454560:1
position: 454560
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:452404-454560:1:exon

YGL022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STT3
locus tag: YGL022W
product: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
transcript id: NM_001180887.1
SIO_010081: YGL022W
subclass of: SO_0000673
so part of: YGL022W
location: <452404..>454560
location: region:452404-454560:1
so has part: feature:452404-454560:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:452404-454560:1:exon

YGL022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STT3
locus tag: YGL022W
EC number: 2.4.99.18
experiment: EXISTENCE:curator inference:GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity [PMID:9405463]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Catalytic subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER lumen; involved in recognition of N-acetylglucosamine; forms a subcomplex with Ost3p and Ost4p
codon start: 1
product: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
translation: MGSDRSCVLSVFQTILKLVIFVAIFGAAISSRLFAVIKFESIIHEFDPWFNYRATKYLVNNSFYKFLNWFDDRTWYPLGRVTGGTLYPGLMTTSAFIWHALRNWLGLPIDIRNVCVLFAPLFSGVTAWATYEFTKEIKDASAGLLAAGFIAIVPGYISRSVAGSYDNEAIAITLLMVTFMFWIKAQKTGSIMHATCAALFYFYMVSAWGGYVFITNLIPLHVFLLILMGRYSSKLYSAYTTWYAIGTVASMQIPFVGFLPIRSNDHMAALGVFGLIQIVAFGDFVKGQISTAKFKVIMMVSLFLILVLGVVGLSALTYMGLIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPVSWPAFFFDTHFLIWLFPAGVFLLFLDLKDEHVFVIAYSVLCSYFAGVMVRLMLTLTPVICVSAAVALSKIFDIYLDFKTSDRKYAIKPAALLAKLIVSGSFIFYLYLFVFHSTWVTRTAYSSPSVVLPSQTPDGKLALIDDFREAYYWLRMNSDEDSKVAAWWDYGYQIGGMADRTTLVDNNTWNNTHIAIVGKAMASPEEKSYEILKEHDVDYVLVIFGGLIGFGGDDINKFLWMIRISEGIWPEEIKERDFYTAEGEYRVDARASETMRNSLLYKMSYKDFPQLFNGGQATDRVRQQMITPLDVPPLDYFDEVFTSENWMVRIYQLKKDDAQGRTLRDVGELTRSSTKTRRSIKRPELGLRV
SIO_010081: YGL022W
subclass of: SO_0000673
so part of: YGL022W
location: 452404..454560
location: region:452404-454560:1
so has part: feature:452404-454560:1:exon

NP_011493.1
type: Protein
SIO_000068: ncbiprotein

S000002990
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:452404-454560:1:exon

YGL021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALK1
locus tag: YGL021W
so part of: sequence
location: <454785..>457067
location: region:454785-457067:1
so has part: feature:454785-457067:1:exon
subclass of: SO_0000010

852863
type: Gene
SIO_000068: ncbigene

position:454785:1
position: 454785
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457067:1
position: 457067
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:454785-457067:1:exon

YGL021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALK1
locus tag: YGL021W
product: protein kinase ALK1
transcript id: NM_001180886.1
SIO_010081: YGL021W
subclass of: SO_0000673
so part of: YGL021W
location: <454785..>457067
location: region:454785-457067:1
so has part: feature:454785-457067:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:454785-457067:1:exon

YGL021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALK1
locus tag: YGL021W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16855400]
experiment: EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:33585466]
note: Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins
codon start: 1
product: protein kinase ALK1
translation: MLLHFDIVIQLLSSHTLKSHQVEPPMDFETSFEEFVEDKRFIALEVSDNDDDCDTDLTADTADELESSAILKMRESDASLNVTTGNNTSRKTTSNSKKRWSLLSNHSAVSSSKSKKRWSVLSSSFTSESHKDRESRNVLQQKRKSLQSYSSLDTVASNSSISASSSLKRSSTGLSLRQLFTKIGINDDISQPGIGIPQGKENLPPTMGKKNSSIASTSSENRLRTPLKPLVNHSKRPTSQPQQQQPLYNASLSSRRSSISSTVSSSSSSKWRFWKRNKNQTPALLQPDHHSLKTFPAVNRRDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSESSDTISSMEITLKNKASSSSLSLNVLKKRNSQSSLKHKSSHASLQKFKRNKGKSSMIAPSTATNSSNDDSCSYSSKNSTLSHRISLPVPDQVSRDKIQNKLRYSTSLLSLNSKSSLPMNKNDHDETLLRQILLNCDIKRILNPAKGDVLPLINDVNHLSSIQLTSNVWQIGEVICKKVSLGTIDDITWDRKFLSLQELEKLKIMQQKFDGIPQLLKSFVVKEANGGLYLYLLFKDHGTPISLISLKNWKQILKIFWSCAGIIHGLEKNLKFEHRNLTLDNILIDGNGNITIIDFKCSRLQTPQDDVLYLRLDHPLFFLNGKDKSKINEYQYQFEFEIYQSMRILLNMDASAFEPMTNLYWLYYLSRVLLKFGDRKLGKNDANRDKMARVINHLEMNLAVHKRGGQLFKRLETEDIKNTGDLLKLYK
SIO_010081: YGL021W
subclass of: SO_0000673
so part of: YGL021W
location: 454785..457067
location: region:454785-457067:1
so has part: feature:454785-457067:1:exon

NP_011494.1
type: Protein
SIO_000068: ncbiprotein

S000002989
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:454785-457067:1:exon

YGL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MDM39
gene: GET1
locus tag: YGL020C
gene synonym: MDM39
so part of: sequence
location: complement(<457163..>457870)
location: region:457163-457870:-1
so has part: feature:457163-457870:-1:exon
subclass of: SO_0000010

852864
type: Gene
SIO_000068: ncbigene

position:457163:-1
position: 457163
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457870:-1
position: 457870
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:457163-457870:-1:exon

YGL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MDM39
gene: GET1
locus tag: YGL020C
gene synonym: MDM39
product: GET complex subunit GET1
transcript id: NM_001180885.1
SIO_010081: YGL020C
subclass of: SO_0000673
so part of: YGL020C
location: complement(<457163..>457870)
location: region:457163-457870:-1
so has part: feature:457163-457870:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:457163-457870:-1:exon

YGL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MDM39
gene: GET1
locus tag: YGL020C
gene synonym: MDM39
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:18724936]
experiment: EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:18724936]
experiment: EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:physical interaction:GO:0043529 GET complex [PMID:16269340]
note: Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
codon start: 1
product: GET complex subunit GET1
translation: MHWAAAVAIFFIVVTKFLQYTNKYHEKWISKFAPGNELSKKYLAKVKERHELKEFNNSISAQDNYAKWTKNNRKLDSLDKEINNLKDEIQSENKAFQAHLHKLRLLALTVPFFVFKIMYGKTPVYKLSSSTSTLFPTFVSGVWSQGWLYVLLHPLRTISQKWHIMEGKFGASKFDDMALQSVSLGIWVWALMNVINGVEFIVKQLFLTPKMEAPASVETQEEKALDAVDDAIILD
SIO_010081: YGL020C
subclass of: SO_0000673
so part of: YGL020C
location: complement(457163..457870)
location: region:457163-457870:-1
so has part: feature:457163-457870:-1:exon

NP_011495.1
type: Protein
SIO_000068: ncbiprotein

S000002988
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:457163-457870:-1:exon

YGL019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CKB1
locus tag: YGL019W
so part of: sequence
location: <458156..>458992
location: region:458156-458992:1
so has part: feature:458156-458992:1:exon
subclass of: SO_0000010

852865
type: Gene
SIO_000068: ncbigene

position:458156:1
position: 458156
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:458992:1
position: 458992
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:458156-458992:1:exon

YGL019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CKB1
locus tag: YGL019W
product: casein kinase 2 regulatory subunit CKB1
transcript id: NM_001180884.3
SIO_010081: YGL019W
subclass of: SO_0000673
so part of: YGL019W
location: <458156..>458992
location: region:458156-458992:1
so has part: feature:458156-458992:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:458156-458992:1:exon

YGL019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CKB1
locus tag: YGL019W
experiment: EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]
experiment: EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0006974 cellular response to DNA damage stimulus [PMID:11551505]
experiment: EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:8135547]
experiment: EXISTENCE:direct assay:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:18265947]
experiment: EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]
experiment: EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11827175]
note: Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
codon start: 1
product: casein kinase 2 regulatory subunit CKB1
translation: MSQEFVEDYSRTGSSDDEDSGAYDEWIPSFCSRFGHEYFCQVPTEFIEDDFNMTSLSQEVPHYRKALDLILDLEAMSDEEEDEDDVVEEDEVDQEMQSNDGHDEGKRRNKSPVVNKSIIEHAAEQLYGLIHARFILTKPGLQAMAEKFDHKEFGTCPRYYCNGMQLLPCGLSDTVGKHTVRLYCPSCQDLYLPQSSRFLCLEGAFWGTSFPGVFLKHFKELEEYVERKSKESYELKVFGFRINDEAVSGPRMKWLRQYPSTEEDWEEFAKCEFETPAV
SIO_010081: YGL019W
subclass of: SO_0000673
so part of: YGL019W
location: 458156..458992
location: region:458156-458992:1
so has part: feature:458156-458992:1:exon

NP_011496.3
type: Protein
SIO_000068: ncbiprotein

S000002987
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:458156-458992:1:exon

YGL018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: JAC1
locus tag: YGL018C
so part of: sequence
location: complement(<459110..>459664)
location: region:459110-459664:-1
so has part: feature:459110-459664:-1:exon
subclass of: SO_0000010

852866
type: Gene
SIO_000068: ncbigene

position:459110:-1
position: 459110
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:459664:-1
position: 459664
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459110-459664:-1:exon

YGL018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: JAC1
locus tag: YGL018C
product: J-type chaperone JAC1
transcript id: NM_001180883.1
SIO_010081: YGL018C
subclass of: SO_0000673
so part of: YGL018C
location: complement(<459110..>459664)
location: region:459110-459664:-1
so has part: feature:459110-459664:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:459110-459664:-1:exon

YGL018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: JAC1
locus tag: YGL018C
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12756240]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11278728|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11171977|PMID:11273703]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:11278728]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9813017]
experiment: EXISTENCE:mutant phenotype:GO:0051087 chaperone binding [PMID:11278728]
experiment: EXISTENCE:mutant phenotype:GO:0097428 protein maturation by iron-sulfur cluster transfer [PMID:11171977]
experiment: EXISTENCE:mutant phenotype:GO:0106034 protein maturation by [2Fe-2S] cluster transfer [PMID:11273703]
experiment: EXISTENCE:mutant phenotype:GO:0106035 protein maturation by [4Fe-4S] cluster transfer [PMID:11278728]
note: Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
codon start: 1
product: J-type chaperone JAC1
translation: MLKYLVQRRFTSTFYELFPKTFPKKLPIWTIDQSRLRKEYRQLQAQHHPDMAQQGSEQSSTLNQAYHTLKDPLRRSQYMLKLLRNIDLTQEQTSNEVTTSDPQLLLKVLDIHDELSQMDDEAGVKLLEKQNKERIQDIEAQLGQCYNDKDYAAAVKLTVELKYWYNLAKAFKDWAPGKQLEMNH
SIO_010081: YGL018C
subclass of: SO_0000673
so part of: YGL018C
location: complement(459110..459664)
location: region:459110-459664:-1
so has part: feature:459110-459664:-1:exon

NP_011497.1
type: Protein
SIO_000068: ncbiprotein

S000002986
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459110-459664:-1:exon

YGL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ATE1
locus tag: YGL017W
so part of: sequence
location: <459854..>461365
location: region:459854-461365:1
so has part: feature:459854-461365:1:exon
subclass of: SO_0000010

852867
type: Gene
SIO_000068: ncbigene

position:459854:1
position: 459854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461365:1
position: 461365
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:459854-461365:1:exon

YGL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ATE1
locus tag: YGL017W
product: arginyltransferase
transcript id: NM_001180882.1
SIO_010081: YGL017W
subclass of: SO_0000673
so part of: YGL017W
location: <459854..>461365
location: region:459854-461365:1
so has part: feature:459854-461365:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:459854-461365:1:exon

YGL017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ATE1
locus tag: YGL017W
EC number: 2.3.2.8
experiment: EXISTENCE:direct assay:GO:0004057 arginyltransferase activity [PMID:2185248]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016598 protein arginylation [PMID:2185248]
experiment: EXISTENCE:mutant phenotype:GO:0004057 arginyltransferase activity [PMID:2185248]
experiment: EXISTENCE:mutant phenotype:GO:0016598 protein arginylation [PMID:2185248]
note: Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; may have a role in regulating stress response
codon start: 1
product: arginyltransferase
translation: MSDRFVIWAPSMHNEPAAKCGYCHGNKGGNMDQLFALDSWAHRYMNKMDVVKIENCTIGSFVEHMDVATYDRMCNMGFRRSGKFLYKVDPLRNCCRLYTIRTAPQELNMTKELKKCISRFATRITSEDYCPAAVASSDFVGKIVNAEMNSKTFYTRFEPALYSEEKYHLFVKYQEKVHQDYNNSPKSFKRFLCDTPFGPEAVLGTQESWEQLNNWQRMKPGEKLKHMGPVHECYYYEGKLIAITVSDILPSGISSVYFIWDPDYSKWSLGKLSALRDLAIIQRTNLQYYYLGYYIEDCPKMNYKANYGAEVLDVCHSKYIPLKPIQDMISRGKLFVIGEEETKVTKELYLVDSETGRGEGFPTDNVVKYKNIAEEIYGVGGCAFKSANESALELKELYGIPYEEEDLDTIYHLKEHNGHAPNGIPNVVPGLLPLWELLDIMQSGKITDLEGRLFLFEIETEGIRPLINFYSEPPNVKKRICDVIRLFGFETCMKAVILYSEQM
SIO_010081: YGL017W
subclass of: SO_0000673
so part of: YGL017W
location: 459854..461365
location: region:459854-461365:1
so has part: feature:459854-461365:1:exon

NP_011498.1
type: Protein
SIO_000068: ncbiprotein

S000002985
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:459854-461365:1:exon

YGL016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PDR6
gene: KAP122
locus tag: YGL016W
gene synonym: PDR6
so part of: sequence
location: <461666..>464911
location: region:461666-464911:1
so has part: feature:461666-464911:1:exon
subclass of: SO_0000010

852868
type: Gene
SIO_000068: ncbigene

position:461666:1
position: 461666
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464911:1
position: 464911
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:461666-464911:1:exon

YGL016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PDR6
gene: KAP122
locus tag: YGL016W
gene synonym: PDR6
product: Kap122p
transcript id: NM_001180881.1
SIO_010081: YGL016W
subclass of: SO_0000673
so part of: YGL016W
location: <461666..>464911
location: region:461666-464911:1
so has part: feature:461666-464911:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:461666-464911:1:exon

YGL016W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PDR6
gene: KAP122
locus tag: YGL016W
gene synonym: PDR6
experiment: EXISTENCE:direct assay:GO:0005049 nuclear export signal receptor activity [PMID:31023724]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:10525531]
experiment: EXISTENCE:direct assay:GO:0051168 nuclear export [PMID:31023724]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:10525531]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:10525531]
experiment: EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:10525531]
note: Karyopherin beta; bidirectional nuclear transport receptor (biportin) that shuttles distinct sets of cargoes in opposite directions; responsible for import of Toa1p-Toa2p complex into nucleus; depletes eIF5A and eEF2 from cell nuclei; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
codon start: 1
product: Kap122p
translation: MSSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQLNTRGENDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQNINADQLLLDSINCSLTYEQLSQFVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQAVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAEKILTIFGNVFANDPLLMSYDLRQQIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIEEEGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTLSESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDALLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFRKELTPQEFDFMFEKILLVYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIVAVAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRSDLNSYTDLLRALVAKFPIEAREWLVAVLPQICNNPAGHEKFINKLLITRGSRAAGNVILQWWLDCTTLPNYQG
SIO_010081: YGL016W
subclass of: SO_0000673
so part of: YGL016W
location: 461666..464911
location: region:461666-464911:1
so has part: feature:461666-464911:1:exon

NP_011499.1
type: Protein
SIO_000068: ncbiprotein

S000002984
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:461666-464911:1:exon

YGL015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BIL2
locus tag: YGL015C
so part of: sequence
location: complement(<465043..>465435)
location: region:465043-465435:-1
so has part: feature:465043-465435:-1:exon
subclass of: SO_0000010

852869
type: Gene
SIO_000068: ncbigene

position:465043:-1
position: 465043
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:465435:-1
position: 465435
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465043-465435:-1:exon

YGL015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BIL2
locus tag: YGL015C
product: Bil2p
transcript id: NM_001180880.3
SIO_010081: YGL015C
subclass of: SO_0000673
so part of: YGL015C
location: complement(<465043..>465435)
location: region:465043-465435:-1
so has part: feature:465043-465435:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465043-465435:-1:exon

YGL015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BIL2
locus tag: YGL015C
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:33634134]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:33634134]
experiment: EXISTENCE:direct assay:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:33634134]
experiment: EXISTENCE:direct assay:GO:0099503 secretory vesicle [PMID:33634134]
note: Formin inhibitor; negatively regulates Bnr1-mediated actin filament nucleation but not filament elongation; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth
codon start: 1
product: Bil2p
translation: MEDTIRPLNYADIETSGPINLLETTNNLKSSLKKFSQKAKGSHISRERIHHFRKWKNKTESLSENHLKPPPDVDSLCFSNCFQPDALSGNVFLPPRSSNMYWNEKQLQLEMEILKFLSLNTSNECCTSDD
SIO_010081: YGL015C
subclass of: SO_0000673
so part of: YGL015C
location: complement(465043..465435)
location: region:465043-465435:-1
so has part: feature:465043-465435:-1:exon

NP_011500.3
type: Protein
SIO_000068: ncbiprotein

S000002983
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465043-465435:-1:exon

YGL014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YGL023
gene: PUF4
locus tag: YGL014W
gene synonym: YGL023
so part of: sequence
location: <466141..>468807
location: region:466141-468807:1
so has part: feature:466141-468807:1:exon
subclass of: SO_0000010

852870
type: Gene
SIO_000068: ncbigene

position:466141:1
position: 466141
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:468807:1
position: 468807
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466141-468807:1:exon

YGL014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YGL023
gene: PUF4
locus tag: YGL014W
gene synonym: YGL023
product: Puf4p
transcript id: NM_001180879.1
SIO_010081: YGL014W
subclass of: SO_0000673
so part of: YGL014W
location: <466141..>468807
location: region:466141-468807:1
so has part: feature:466141-468807:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466141-468807:1:exon

YGL014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YGL023
gene: PUF4
locus tag: YGL014W
gene synonym: YGL023
experiment: EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:17389596]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:18327269|PMID:15024427|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:20427513]
experiment: EXISTENCE:genetic interaction:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]
experiment: EXISTENCE:mutant phenotype:GO:0008104 protein localization [PMID:9150138]
note: Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
codon start: 1
product: Puf4p
translation: MSTKGLKEEIDDVPSVDPVVSETVNSALEQLQLDDPEENATSNAFANKVSQDSQFANGPPSQMFPHPQMMGGMGFMPYSQMMQVPHNPCPFFPPPDFNDPTAPLSSSPLNAGGPPMLFKNDSLPFQMLSSGAAVATQGGQNLNPLINDNSMKVLPIASADPLWTHSNVPGSASVAIEETTATLQESLPSKGRESNNKASSFRRQTFHALSPTDLINAANNVTLSKDFQSDMQNFSKAKKPSVGANNTAKTRTQSISFDNTPSSTSFIPPTNSVSEKLSDFKIETSKEDLINKTAPAKKESPTTYGAAYPYGGPLLQPNPIMPGHPHNISSPIYGIRSPFPNSYEMGAQFQPFSPILNPTSHSLNANSPIPLTQSPIHLAPVLNPSSNSVAFSDMKNDGGKPTTDNDKAGPNVRMDLINPNLGPSMQPFHILPPQQNTPPPPWLYSTPPPFNAMVPPHLLAQNHMPLMNSANNKHHGRNNNSMSSHNDNDNIGNSNYNNKDTGRSNVGKMKNMKNSYHGYYNNNNNNNNNNNNNNNSNATNSNSAEKQRKIEESSRFADAVLDQYIGSIHSLCKDQHGCRFLQKQLDILGSKAADAIFEETKDYTVELMTDSFGNYLIQKLLEEVTTEQRIVLTKISSPHFVEISLNPHGTRALQKLIECIKTDEEAQIVVDSLRPYTVQLSKDLNGNHVIQKCLQRLKPENFQFIFDAISDSCIDIATHRHGCCVLQRCLDHGTTEQCDNLCDKLLALVDKLTLDPFGNYVVQYIITKEAEKNKYDYTHKIVHLLKPRAIELSIHKFGSNVIEKILKTAIVSEPMILEILNNGGETGIQSLLNDSYGNYVLQTALDISHKQNDYLYKRLSEIVAPLLVGPIRNTPHGKRIIGMLHLDS
SIO_010081: YGL014W
subclass of: SO_0000673
so part of: YGL014W
location: 466141..468807
location: region:466141-468807:1
so has part: feature:466141-468807:1:exon

NP_011501.1
type: Protein
SIO_000068: ncbiprotein

S000002982
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466141-468807:1:exon

YGL013C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AMY1
alternative label: ANT1
alternative label: BOR2
alternative label: CYH3
alternative label: NRA2
alternative label: SMR2
alternative label: TIL1
alternative label: TPE1
alternative label: TPE3
gene: PDR1
locus tag: YGL013C
gene synonym: AMY1; ANT1; BOR2; CYH3; NRA2; SMR2; TIL1; TPE1; TPE3
so part of: sequence
location: complement(<469092..>472298)
location: region:469092-472298:-1
so has part: feature:469092-472298:-1:exon
subclass of: SO_0000010

852871
type: Gene
SIO_000068: ncbigene

position:469092:-1
position: 469092
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472298:-1
position: 472298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469092-472298:-1:exon

YGL013C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AMY1
alternative label: ANT1
alternative label: BOR2
alternative label: CYH3
alternative label: NRA2
alternative label: SMR2
alternative label: TIL1
alternative label: TPE1
alternative label: TPE3
gene: PDR1
locus tag: YGL013C
gene synonym: AMY1; ANT1; BOR2; CYH3; NRA2; SMR2; TIL1; TPE1; TPE3
product: drug-responsive transcription factor PDR1
transcript id: NM_001180878.1
SIO_010081: YGL013C
subclass of: SO_0000673
so part of: YGL013C
location: complement(<469092..>472298)
location: region:469092-472298:-1
so has part: feature:469092-472298:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469092-472298:-1:exon

YGL013C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AMY1
alternative label: ANT1
alternative label: BOR2
alternative label: CYH3
alternative label: NRA2
alternative label: SMR2
alternative label: TIL1
alternative label: TPE1
alternative label: TPE3
gene: PDR1
locus tag: YGL013C
gene synonym: AMY1; ANT1; BOR2; CYH3; NRA2; SMR2; TIL1; TPE1; TPE3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11136452|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:genetic interaction:GO:2001040 positive regulation of cellular response to drug [PMID:8078477]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8798494|PMID:9428726]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8798494|PMID:9428726]
experiment: EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:15713640|PMID:9767597]
note: Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
codon start: 1
product: drug-responsive transcription factor PDR1
translation: MRGLTPKNGVHIETGPDTESSADSSNFSTGFSGKIRKPRSKVSKACDNCRKRKIKCNGKFPCASCEIYSCECTFSTRQGGARIKNLHKTSLEGTTVQVKEETDSSSTSFSNPQRCTDGPCAVEQPTKFFENFKLGGRSSGDNSGSDGKNDDDVNRNGFYEDDSESQATLTSLQTTLKNLKEMAHLGTHVTSAIESIELQISDLLKRWEPKVRTKELATTKFYPNKSIETQLMKNKYCDVVHLTRYAAWSNNKKDQDTSSQPLIDEIFGLYSPFQFLSLQGIGKCFQNYRSKSKCEIFPRTAKETIYIMLRFFDVCFHHINQGCVSIANPLENYLQKMNLLPSTPSSISSAGSPNTAHTKSHVALVINHLPQPFVRNITGISNSELLSEMNNDISMFGILLKMLDMHKNSYQNFLMEITSNPSVAKNTQSIDVLQEFIHYCQAGEALIALCYSYYNSTLYNYVDFTCDITHLEQLLYFLDLLFWLSEIYGFEKVLNVAVHFVSRVGLSRWEFYVGLDENFAERRRNLWWKAFYFEKTLASKLGYPSNIDDSKINCLLPKNFRDVGFLDNRDFIENVHLVRRSEAFDNMCISDLKYYGELAVLQIVSHFSSSVLFNEKFTSIRNTSKPSVVREKLLFEVLEIFNETEMKYDAIKEQTGKLFDIAFSKDSTELKVSREDKIMASKFVLFYEHHFCRMVNESDNIVARLCVHRRPSILIENLKIYLHKIYKSWTDMNKILLDFDNDYSVYRSFAHYSISCIILVSQAFSVAEFIKVNDVVNMIRVFKRFLDIKIFSENETNEHVFNSQSFKDYTRAFSFLTIVTRIMLLAYGESSSTNLDVISKYIDENAPDLKGIIELVLDTNSCAYRFLLEPVQKSGFHLTVSQMLKNRKFQEPLMSNEDNKQMKHNSGKNLNPDLPSLKTGTSCLLNGIESPQLPFNGRSAPSPVRNNSLPEFAQLPSFRSLSVSDMINPDYAQPTNGQNNTQVQSNKPINAQQQIPTSVQVPFMNTNEINNNNNNNNNNKNNINNINNNNSNNFSATSFNLGTLDEFVNNGDLEDLYSILWSDVYPDS
SIO_010081: YGL013C
subclass of: SO_0000673
so part of: YGL013C
location: complement(469092..472298)
location: region:469092-472298:-1
so has part: feature:469092-472298:-1:exon

NP_011502.1
type: Protein
SIO_000068: ncbiprotein

S000002981
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469092-472298:-1:exon

YGL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG4
locus tag: YGL012W
so part of: sequence
location: <472855..>474276
location: region:472855-474276:1
so has part: feature:472855-474276:1:exon
subclass of: SO_0000010

852872
type: Gene
SIO_000068: ncbigene

position:472855:1
position: 472855
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:474276:1
position: 474276
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472855-474276:1:exon

YGL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG4
locus tag: YGL012W
product: delta(24(24(1)))-sterol reductase
transcript id: NM_001180877.1
SIO_010081: YGL012W
subclass of: SO_0000673
so part of: YGL012W
location: <472855..>474276
location: region:472855-474276:1
so has part: feature:472855-474276:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472855-474276:1:exon

YGL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG4
locus tag: YGL012W
EC number: 1.3.1.71
experiment: EXISTENCE:direct assay:GO:0000246 delta24(24-1) sterol reductase activity [PMID:14922]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10722850|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10722850]
experiment: EXISTENCE:direct assay:GO:0050614 delta24-sterol reductase activity [PMID:10722850]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8125337]
note: C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
codon start: 1
product: delta(24(24(1)))-sterol reductase
translation: MAKDNSEKLQVQGEEKKSKQPVNFLPQGKWLKPNEIEYEFGGTTGVIGMLIGFPLLMYYMWICAEFYHGKVALPKAGESWMHFIKHLYQLVLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLKGKQLPYFCNAMWTLYVTTTLVLVLHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLWTLFISHDYHRMTGNHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACLKQWETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF
SIO_010081: YGL012W
subclass of: SO_0000673
so part of: YGL012W
location: 472855..474276
location: region:472855-474276:1
so has part: feature:472855-474276:1:exon

NP_011503.1
type: Protein
SIO_000068: ncbiprotein

S000002980
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472855-474276:1:exon

YGL011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PRC2
gene: SCL1
locus tag: YGL011C
gene synonym: PRC2
so part of: sequence
location: complement(<474489..>475247)
location: region:474489-475247:-1
so has part: feature:474489-475247:-1:exon
subclass of: SO_0000010

852873
type: Gene
SIO_000068: ncbigene

position:474489:-1
position: 474489
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:475247:-1
position: 475247
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:474489-475247:-1:exon

YGL011C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PRC2
gene: SCL1
locus tag: YGL011C
gene synonym: PRC2
product: proteasome core particle subunit alpha 1
transcript id: NM_001180876.3
SIO_010081: YGL011C
subclass of: SO_0000673
so part of: YGL011C
location: complement(<474489..>475247)
location: region:474489-475247:-1
so has part: feature:474489-475247:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:474489-475247:-1:exon

YGL011C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PRC2
gene: SCL1
locus tag: YGL011C
gene synonym: PRC2
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0034515 proteasome storage granule [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
note: Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
codon start: 1
product: proteasome core particle subunit alpha 1
translation: MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD
SIO_010081: YGL011C
subclass of: SO_0000673
so part of: YGL011C
location: complement(474489..475247)
location: region:474489-475247:-1
so has part: feature:474489-475247:-1:exon

NP_011504.3
type: Protein
SIO_000068: ncbiprotein

S000002979
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:474489-475247:-1:exon

YGL010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MPO1
locus tag: YGL010W
so part of: sequence
location: <475545..>476069
location: region:475545-476069:1
so has part: feature:475545-476069:1:exon
subclass of: SO_0000010

852874
type: Gene
SIO_000068: ncbigene

position:475545:1
position: 475545
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:476069:1
position: 476069
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475545-476069:1:exon

YGL010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MPO1
locus tag: YGL010W
product: Mpo1p
transcript id: NM_001180875.1
SIO_010081: YGL010W
subclass of: SO_0000673
so part of: YGL010W
location: <475545..>476069
location: region:475545-476069:1
so has part: feature:475545-476069:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:475545-476069:1:exon

YGL010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MPO1
locus tag: YGL010W
EC number: 1.14.18.12
experiment: EXISTENCE:direct assay:GO:0001561 fatty acid alpha-oxidation [PMID:30530523]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0102672 fatty acid alpha-oxygenase activity [PMID:30530523]
experiment: EXISTENCE:mutant phenotype:GO:0046521 sphingoid catabolic process [PMID:25345524]
note: Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene
codon start: 1
product: Mpo1p
translation: MGEGLLDLRSQLGFYKFYHHNPKNVLIHSIFVPTILFSGSCMLHRVKIYQSISLTAVLSVLFSIFYCLLYLPTGLLAGVLLLLLNLALIDHRVDLTFKQELGLFTIGWIFQFVGHGVFEKRRPALIDNLVQSLVLAPYFIMFEFLFKLGFMPRLKATLEHDLEIKQRNLRMQRQ
SIO_010081: YGL010W
subclass of: SO_0000673
so part of: YGL010W
location: 475545..476069
location: region:475545-476069:1
so has part: feature:475545-476069:1:exon

NP_011505.1
type: Protein
SIO_000068: ncbiprotein

S000002978
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475545-476069:1:exon

YGL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LEU1
locus tag: YGL009C
so part of: sequence
location: complement(<476313..>478652)
location: region:476313-478652:-1
so has part: feature:476313-478652:-1:exon
subclass of: SO_0000010

852875
type: Gene
SIO_000068: ncbigene

position:476313:-1
position: 476313
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:478652:-1
position: 478652
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476313-478652:-1:exon

YGL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LEU1
locus tag: YGL009C
product: 3-isopropylmalate dehydratase LEU1
transcript id: NM_001180874.1
SIO_010081: YGL009C
subclass of: SO_0000673
so part of: YGL009C
location: complement(<476313..>478652)
location: region:476313-478652:-1
so has part: feature:476313-478652:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476313-478652:-1:exon

YGL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LEU1
locus tag: YGL009C
EC number: 4.2.1.33
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:4355481]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0003861 3-isopropylmalate dehydratase activity [PMID:5724969]
experiment: EXISTENCE:mutant phenotype:GO:0009098 leucine biosynthetic process [PMID:5724969|PMID:6323436]
note: Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway
codon start: 1
product: 3-isopropylmalate dehydratase LEU1
translation: MVYTPSKGPRTLYDKVFDAHVVHQDENGSFLLYIDRHLVHEVTSPQAFEGLENAGRKVRRVDCTLATVDHNIPTESRKNFKSLDTFIKQTDSRLQVKTLENNVKQFGVPYFGMSDARQGIVHTIGPEEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGARAGMIKPDETTFQYTKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPTITWGTSPQDALPITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSCTNGRIEDLRSAAAVVRGQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWREAGCSICLGMNPDILDAYERCASTSNRNFEGRQGALSRTHLMSPAMAAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSEDEKELESAAYDHAEPVQPEDAPQDIANDELKDIPVKSDDTPAKPSSSGMKPFLTLEGISAPLDKANVDTDAIIPKQFLKTIKRTGLKKGLFYEWRFRKDDQGKDQETDFVLNVEPWREAEILVVTGDNFGCGSSREHAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCVDLPNQKILDSDGNVLVDHFEIEPFRKHCLVNGLDDIGITLQKEEYISRYEALRREKYSFLEGGSKLLKFDNVPKRKAVTTTFDKVHQDW
SIO_010081: YGL009C
subclass of: SO_0000673
so part of: YGL009C
location: complement(476313..478652)
location: region:476313-478652:-1
so has part: feature:476313-478652:-1:exon

NP_011506.1
type: Protein
SIO_000068: ncbiprotein

S000002977
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476313-478652:-1:exon

YGL008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KTI10
gene: PMA1
locus tag: YGL008C
gene synonym: KTI10
so part of: sequence
location: complement(<479910..>482666)
location: region:479910-482666:-1
so has part: feature:479910-482666:-1:exon
subclass of: SO_0000010

852876
type: Gene
SIO_000068: ncbigene

position:479910:-1
position: 479910
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482666:-1
position: 482666
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:479910-482666:-1:exon

YGL008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KTI10
gene: PMA1
locus tag: YGL008C
gene synonym: KTI10
product: H(+)-exporting P2-type ATPase PMA1
transcript id: NM_001180873.1
SIO_010081: YGL008C
subclass of: SO_0000673
so part of: YGL008C
location: complement(<479910..>482666)
location: region:479910-482666:-1
so has part: feature:479910-482666:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:479910-482666:-1:exon

YGL008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KTI10
gene: PMA1
locus tag: YGL008C
gene synonym: KTI10
EC number: 7.1.2.1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11739806|PMID:12469340|PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0008553 P-type proton-exporting transporter activity [PMID:17912695]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:10716729]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8396147]
experiment: EXISTENCE:direct assay:GO:1902600 proton transmembrane transport [PMID:8396147]
experiment: EXISTENCE:mutant phenotype:GO:1902906 proteasome storage granule assembly [PMID:23690178]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:29570051]
note: Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
codon start: 1
product: H(+)-exporting P2-type ATPase PMA1
translation: MTDTSSSSSSSSASSVSAHQPTQEKPAKTYDDAASESSDDDDIDALIEELQSNHGVDDEDSDNDGPVAAGEARPVPEEYLQTDPSYGLTSDEVLKRRKKYGLNQMADEKESLVVKFVMFFVGPIQFVMEAAAILAAGLSDWVDFGVICGLLMLNAGVGFVQEFQAGSIVDELKKTLANTAVVIRDGQLVEIPANEVVPGDILQLEDGTVIPTDGRIVTEDCFLQIDQSAITGESLAVDKHYGDQTFSSSTVKRGEGFMVVTATGDNTFVGRAAALVNKAAGGQGHFTEVLNGIGIILLVLVIATLLLVWTACFYRTNGIVRILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLKQYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPRDDTAQTVSEARHLGLRVKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILDNSLDIDLIVFIAIFADVATLAIAYDNAPYSPKPVKWNLPRLWGMSIILGIVLAIGSWITLTTMFLPKGGIIQNFGAMNGIMFLQISLTENWLIFITRAAGPFWSSIPSWQLAGAVFAVDIIATMFTLFGWWSENWTDIVTVVRVWIWSIGIFCVLGGFYYEMSTSEAFDRLMNGKPMKEKKSTRSVEDFMAAMQRVSTQHEKET
SIO_010081: YGL008C
subclass of: SO_0000673
so part of: YGL008C
location: complement(479910..482666)
location: region:479910-482666:-1
so has part: feature:479910-482666:-1:exon

NP_011507.1
type: Protein
SIO_000068: ncbiprotein

S000002976
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:479910-482666:-1:exon

YGL007C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL007C-A
so part of: sequence
location: complement(<482941..>483027)
location: region:482941-483027:-1
so has part: feature:482941-483027:-1:exon
subclass of: SO_0000010

1466455
type: Gene
SIO_000068: ncbigene

position:482941:-1
position: 482941
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483027:-1
position: 483027
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:482941-483027:-1:exon

YGL007C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL007C-A
product: uncharacterized protein
transcript id: NM_001184592.3
SIO_010081: YGL007C-A
subclass of: SO_0000673
so part of: YGL007C-A
location: complement(<482941..>483027)
location: region:482941-483027:-1
so has part: feature:482941-483027:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:482941-483027:-1:exon

YGL007C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL007C-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding
codon start: 1
product: uncharacterized protein
translation: MLPSISFDYIKRPNIVLFSNVLSLSSNI
SIO_010081: YGL007C-A
subclass of: SO_0000673
so part of: YGL007C-A
location: complement(482941..483027)
location: region:482941-483027:-1
so has part: feature:482941-483027:-1:exon

NP_878075.3
type: Protein
SIO_000068: ncbiprotein

S000028632
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:482941-483027:-1:exon

YGL007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BRP1
locus tag: YGL007W
so part of: sequence
location: <483260..>483637
location: region:483260-483637:1
so has part: feature:483260-483637:1:exon
subclass of: SO_0000010

852877
type: Gene
SIO_000068: ncbigene

position:483260:1
position: 483260
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:483637:1
position: 483637
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483260-483637:1:exon

YGL007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BRP1
locus tag: YGL007W
product: Brp1p
transcript id: NM_001348838.1
SIO_010081: YGL007W
subclass of: SO_0000673
so part of: YGL007W
location: <483260..>483637
location: region:483260-483637:1
so has part: feature:483260-483637:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483260-483637:1:exon

YGL007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BRP1
locus tag: YGL007W
note: hypothetical protein; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1
codon start: 1
product: Brp1p
translation: MMEKEGKKPERHMDNILKMSIPVKSMSEVSRPGSAALGNTDAMRASLRNSRRSFSGHVRLVLRLVYGFISAVIIAGSPLRDRVCFQITGKGQAKQSDVWVIPAMPVYVSPFQEACFVFSPSAMVT
SIO_010081: YGL007W
subclass of: SO_0000673
so part of: YGL007W
location: 483260..483637
location: region:483260-483637:1
so has part: feature:483260-483637:1:exon

NP_001335779.1
type: Protein
SIO_000068: ncbiprotein

S000002975
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483260-483637:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS719; Autonomously Replicating Sequence
so part of: sequence
location: 484930..485157
location: region:484930-485157:1
so has part: feature:484930-485157:1:region

S000118459
type: SGD
SIO_000068: sgd

position:484930:1
position: 484930
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:485157:1
position: 485157
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484930-485157:1:region

YGL006W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGL006W-A
so part of: sequence
location: <485423..>485533
location: region:485423-485533:1
so has part: feature:485423-485533:1:exon
subclass of: SO_0000010

1466456
type: Gene
SIO_000068: ncbigene

position:485423:1
position: 485423
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:485533:1
position: 485533
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485423-485533:1:exon

YGL006W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGL006W-A
product: uncharacterized protein
transcript id: NM_001184634.1
SIO_010081: YGL006W-A
subclass of: SO_0000673
so part of: YGL006W-A
location: <485423..>485533
location: region:485423-485533:1
so has part: feature:485423-485533:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485423-485533:1:exon

YGL006W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGL006W-A
note: hypothetical protein; identified by SAGE
codon start: 1
product: uncharacterized protein
translation: MLIFIIHYHRHLALHLMGAFQKHSNSISPPPRKGFI
SIO_010081: YGL006W-A
subclass of: SO_0000673
so part of: YGL006W-A
location: 485423..485533
location: region:485423-485533:1
so has part: feature:485423-485533:1:exon

NP_878076.1
type: Protein
SIO_000068: ncbiprotein

S000028769
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485423-485533:1:exon

YGL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMC1
locus tag: YGL006W
so part of: sequence
location: <485921..>489442
location: region:485921-489442:1
so has part: feature:485921-489442:1:exon
subclass of: SO_0000010

852878
type: Gene
SIO_000068: ncbigene

position:485921:1
position: 485921
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:489442:1
position: 489442
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:485921-489442:1:exon

YGL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMC1
locus tag: YGL006W
product: calcium-transporting ATPase PMC1
transcript id: NM_001180871.1
SIO_010081: YGL006W
subclass of: SO_0000673
so part of: YGL006W
location: <485921..>489442
location: region:485921-489442:1
so has part: feature:485921-489442:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:485921-489442:1:exon

YGL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMC1
locus tag: YGL006W
EC number: 7.2.2.10
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:24124599|PMID:7507493|PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0005388 P-type calcium transporter activity [PMID:7507493]
experiment: EXISTENCE:mutant phenotype:GO:0005388 P-type calcium transporter activity [PMID:10431803]
experiment: EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:15280017|PMID:7507493]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:7507493]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:7507493]
note: Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a
codon start: 1
product: calcium-transporting ATPase PMC1
translation: MSRQDENSALLANNENNKPSYTGNENGVYDNFKLSKSQLSDLHNPKSIRSFVRLFGYESNSLFKYLKTDKNAGISLPEISNYRKTNRYKNYGDNSLPERIPKSFLQLVWAAFNDKTMQLLTVAAVVSFVLGLYELWMQPPQYDPEGNKIKQVDWIEGVAIMIAVFVVVLVSAANDYQKELQFAKLNKKKENRKIIVIRNDQEILISIHHVLVGDVISLQTGDVVPADCVMISGKCEADESSITGESNTIQKFPVDNSLRDFKKFNSIDSHNHSKPLDIGDVNEDGNKIADCMLISGSRILSGLGRGVITSVGINSVYGQTMTSLNAEPESTPLQLHLSQLADNISVYGCVSAIILFLVLFTRYLFYIIPEDGRFHDLDPAQKGSKFMNIFITSITVIVVAVPEGLPLAVTLALAFATTRMTKDGNLVRVLRSCETMGSATAVCSDKTGTLTENVMTVVRGFPGNSKFDDSKSLPVSEQRKLNSKKVFEENCSSSLRNDLLANIVLNSTAFENRDYKKNDKNTNGSKNMSKNLSFLDKCKSRLSFFKKGNREDDEDQLFKNVNKGRQEPFIGSKTETALLSLARLSLGLQPGELQYLRDQPMEKFNIEKVVQTIPFESSRKWAGLVVKYKEGKNKKPFYRFFIKGAAEIVSKNCSYKRNSDDTLEEINEDNKKETDDEIKNLASDALRAISVAHKDFCECDSWPPEQLRDKDSPNIAALDLLFNSQKGLILDGLLGIQDPLRAGVRESVQQCQRAGVTVRMVTGDNILTAKAIARNCAILSTDISSEAYSAMEGTEFRKLTKNERIRILPNLRVLARSSPEDKRLLVETLKGMGDVVAVTGDGTNDAPALKLADVGFSMGISGTEVAREASDIILMTDDFSAIVNAIKWGRCVSVSIKKFIQFQLIVNITAVILTFVSSVASSDETSVLTAVQLLWINLIMDTLAALALATDKPDPNIMDRKPRGRSTSLISVSTWKMILSQATLQLIVTFILHFYGPELFFKKHEDEITSHQQQQLNAMTFNTFVWLQFFTMLVSRKLDEGDGISNWRGRISAANLNFFQDLGRNYYFLTIMAIIGSCQVLIMFFGGAPFSIARQTKSMWITAVLCGMLSLIMGVLVRICPDEVAVKVFPAAFVQRFKYVFGLEFLRKNHTGKHDDEEALLEESDSPESTAFY
SIO_010081: YGL006W
subclass of: SO_0000673
so part of: YGL006W
location: 485921..489442
location: region:485921-489442:1
so has part: feature:485921-489442:1:exon

NP_011509.1
type: Protein
SIO_000068: ncbiprotein

S000002974
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:485921-489442:1:exon

YGL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COD5
gene: COG7
locus tag: YGL005C
gene synonym: COD5
so part of: sequence
location: complement(<489708..>490547)
location: region:489708-490547:-1
so has part: feature:489708-490547:-1:exon
subclass of: SO_0000010

852879
type: Gene
SIO_000068: ncbigene

position:489708:-1
position: 489708
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490547:-1
position: 490547
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:489708-490547:-1:exon

YGL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COD5
gene: COG7
locus tag: YGL005C
gene synonym: COD5
product: Golgi transport complex subunit COG7
transcript id: NM_001180870.1
SIO_010081: YGL005C
subclass of: SO_0000673
so part of: YGL005C
location: complement(<489708..>490547)
location: region:489708-490547:-1
so has part: feature:489708-490547:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:489708-490547:-1:exon

YGL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COD5
gene: COG7
locus tag: YGL005C
gene synonym: COD5
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
note: Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG7
translation: MVELTITGDDDDILSMFFDEEFVPHAFVDILLSNALNEDQIQTQSVSSLLLTRLDFYTKNLTKELESTIWNLDKLSQTLPRTWASSRYHKEAEQNDSSLYSTESLKSSKLEYYLDTLASAVRALETGMHNVTEKLSDLDNENNRNTNVRQQLQSLMLIKERIEKVVYYLEQVRTVTNISTVRENNTTSTGTDLSITDFRTSLKALEDTIDESLSSAIDNEAKDETNKDLIGRIDSLSELKCLFKGLDKFFAEYSNFSESIKSKAQSYLSTKNIDDGMIS
SIO_010081: YGL005C
subclass of: SO_0000673
so part of: YGL005C
location: complement(489708..490547)
location: region:489708-490547:-1
so has part: feature:489708-490547:-1:exon

NP_011510.1
type: Protein
SIO_000068: ncbiprotein

S000002973
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:489708-490547:-1:exon

YGL004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPN14
locus tag: YGL004C
so part of: sequence
location: complement(<490703..>491956)
location: region:490703-491956:-1
so has part: feature:490703-491956:-1:exon
subclass of: SO_0000010

852880
type: Gene
SIO_000068: ncbigene

position:490703:-1
position: 490703
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:491956:-1
position: 491956
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:490703-491956:-1:exon

YGL004C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPN14
locus tag: YGL004C
product: Rpn14p
transcript id: NM_001180869.3
SIO_010081: YGL004C
subclass of: SO_0000673
so part of: YGL004C
location: complement(<490703..>491956)
location: region:490703-491956:-1
so has part: feature:490703-491956:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:490703-491956:-1:exon

YGL004C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPN14
locus tag: YGL004C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19446323]
experiment: EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:19412159]
experiment: EXISTENCE:genetic interaction:GO:0070682 proteasome regulatory particle assembly [PMID:19412159|PMID:19446322|PMID:19446323]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17499717]
experiment: EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19446323]
note: Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
codon start: 1
product: Rpn14p
translation: MTKTITVAHIQYDFKAVLEENDENDDEFYINVDKNLNEIKEHKIVVLGNSRGVDAGKGNTFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSNP
SIO_010081: YGL004C
subclass of: SO_0000673
so part of: YGL004C
location: complement(490703..491956)
location: region:490703-491956:-1
so has part: feature:490703-491956:-1:exon

NP_011511.3
type: Protein
SIO_000068: ncbiprotein

S000002972
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:490703-491956:-1:exon

YGL003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HCT1
gene: CDH1
locus tag: YGL003C
gene synonym: HCT1
so part of: sequence
location: complement(<492474..>494174)
location: region:492474-494174:-1
so has part: feature:492474-494174:-1:exon
subclass of: SO_0000010

852881
type: Gene
SIO_000068: ncbigene

position:492474:-1
position: 492474
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:494174:-1
position: 494174
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492474-494174:-1:exon

YGL003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HCT1
gene: CDH1
locus tag: YGL003C
gene synonym: HCT1
product: Cdh1p
transcript id: NM_001180868.1
SIO_010081: YGL003C
subclass of: SO_0000673
so part of: YGL003C
location: complement(<492474..>494174)
location: region:492474-494174:-1
so has part: feature:492474-494174:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:492474-494174:-1:exon

YGL003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HCT1
gene: CDH1
locus tag: YGL003C
gene synonym: HCT1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12456658]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12456658]
experiment: EXISTENCE:direct assay:GO:0030332 cyclin binding [PMID:11566880]
experiment: EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:17178718]
experiment: EXISTENCE:direct assay:GO:1904668 positive regulation of ubiquitin protein ligase activity [PMID:15060174]
experiment: EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:19362536|PMID:15060174]
experiment: EXISTENCE:direct assay:GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process [PMID:18172166]
experiment: EXISTENCE:genetic interaction:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:16688214]
experiment: EXISTENCE:genetic interaction:GO:0120151 positive regulation of mitotic actomyosin contractile ring disassembly [PMID:19109423]
experiment: EXISTENCE:genetic interaction:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]
experiment: EXISTENCE:mutant phenotype:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:16688214]
experiment: EXISTENCE:mutant phenotype:GO:0045842 positive regulation of mitotic metaphase/anaphase transition [PMID:9831566]
experiment: EXISTENCE:mutant phenotype:GO:0120151 positive regulation of mitotic actomyosin contractile ring disassembly [PMID:19109423]
experiment: EXISTENCE:mutant phenotype:GO:1902426 deactivation of mitotic spindle assembly checkpoint [PMID:25025567]
experiment: EXISTENCE:mutant phenotype:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]
experiment: EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:9831566]
note: Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated
codon start: 1
product: Cdh1p
translation: MSTNLNPFMNNTPSSSPLKGSESKRVSKRPISSSSSASLLSSPSRRSRPSTVYGDRYIPSRTDIDFNSIVSISSMASVPALNPSSTEDQVEYQKERQAHETYNTLLKNELFGEMLSKDTVGSESSIDRIKNTRPSTRGNVHAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTPRRLFTSQQDEITRPSSNSVRGASLLTYQQRKGRRLSAASLLQSQFFDSMSPVRPDSKQLLLSPGKQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDKPKAKVQPNSLIFDAFNQIR
SIO_010081: YGL003C
subclass of: SO_0000673
so part of: YGL003C
location: complement(492474..494174)
location: region:492474-494174:-1
so has part: feature:492474-494174:-1:exon

NP_011512.1
type: Protein
SIO_000068: ncbiprotein

S000002971
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:492474-494174:-1:exon

YGL002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERP6
locus tag: YGL002W
so part of: sequence
location: <494517..>495167
location: region:494517-495167:1
so has part: feature:494517-495167:1:exon
subclass of: SO_0000010

852882
type: Gene
SIO_000068: ncbigene

position:494517:1
position: 494517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:495167:1
position: 495167
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:494517-495167:1:exon

YGL002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERP6
locus tag: YGL002W
product: Erp6p
transcript id: NM_001180867.1
SIO_010081: YGL002W
subclass of: SO_0000673
so part of: YGL002W
location: <494517..>495167
location: region:494517-495167:1
so has part: feature:494517-495167:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:494517-495167:1:exon

YGL002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERP6
locus tag: YGL002W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]
note: Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
codon start: 1
product: Erp6p
translation: MLSHYIFLAFVLLPFRVSAFYFYGYGGDRKCFLKELSKDTLLKGSYNLEVYDDKLADYALPSYNDYGIVIDVEEVFDNNHRVVHQQGSPSGDFSFLALESGEYKICLQSRVNNWVGKTKTKLEIEFEVGFEAMLDMQRKETLESLHGKVSILNSKIVDIRREQQLMREREESFRDISESVNSRAMWWTVTQVTLLIIICVWQMKSLRSFFVKQKVL
SIO_010081: YGL002W
subclass of: SO_0000673
so part of: YGL002W
location: 494517..495167
location: region:494517-495167:1
so has part: feature:494517-495167:1:exon

NP_011513.1
type: Protein
SIO_000068: ncbiprotein

S000002970
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:494517-495167:1:exon

YGL001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG26
locus tag: YGL001C
so part of: sequence
location: complement(<495453..>496502)
location: region:495453-496502:-1
so has part: feature:495453-496502:-1:exon
subclass of: SO_0000010

852883
type: Gene
SIO_000068: ncbigene

position:495453:-1
position: 495453
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:496502:-1
position: 496502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:495453-496502:-1:exon

YGL001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG26
locus tag: YGL001C
product: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
transcript id: NM_001180866.1
SIO_010081: YGL001C
subclass of: SO_0000673
so part of: YGL001C
location: complement(<495453..>496502)
location: region:495453-496502:-1
so has part: feature:495453-496502:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:495453-496502:-1:exon

YGL001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG26
locus tag: YGL001C
EC number: 1.1.1.170
experiment: EXISTENCE:direct assay:GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity [PMID:9811880]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11279045|PMID:26928762|PMID:12119386]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:9811880]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9811880]
experiment: EXISTENCE:mutant phenotype:GO:0047012 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity [PMID:9811880]
note: C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456
codon start: 1
product: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
translation: MSKIDSVLIIGGSGFLGLHLIQQFFDINPKPDIHIFDVRDLPEKLSKQFTFNVDDIKFHKGDLTSPDDMENAINESKANVVVHCASPMHGQNPDIYDIVNVKGTRNVIDMCKKCGVNILVYTSSAGVIFNGQDVHNADETWPIPEVPMDAYNETKAIAEDMVLKANDPSSDFYTVALRPAGIFGPGDRQLVPGLRQVAKLGQSKFQIGDNNNLFDWTYAGNVADAHVLAAQKLLDPKTRTAVSGETFFITNDTPTYFWALARTVWKADGHIDKHVIVLKRPVAICAGYLSEWVSKMLGKEPGLTPFRVKIVCAYRYHNIAKAKKLLGYTPRVGIEEGINKTLAWMDEGL
SIO_010081: YGL001C
subclass of: SO_0000673
so part of: YGL001C
location: complement(495453..496502)
location: region:495453-496502:-1
so has part: feature:495453-496502:-1:exon

NP_011514.1
type: Protein
SIO_000068: ncbiprotein

S000002969
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:495453-496502:-1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN7; Chromosome VII centromere
so part of: sequence
location: complement(496920..497038)
location: region:496920-497038:-1
so has part: feature:496920-497038:-1:region

S000006468
type: SGD
SIO_000068: sgd

position:496920:-1
position: 496920
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:497038:-1
position: 497038
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496920-497038:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN7_CDEIII of CEN7
so part of: sequence
location: complement(496920..496944)
location: region:496920-496944:-1
so has part: feature:496920-496944:-1:region

position:496944:-1
position: 496944
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496920-496944:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN7_CDEII of CEN7
so part of: sequence
location: complement(496945..497028)
location: region:496945-497028:-1
so has part: feature:496945-497028:-1:region

position:496945:-1
position: 496945
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:497028:-1
position: 497028
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496945-497028:-1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN7_CDEI of CEN7
so part of: sequence
location: complement(497029..497038)
location: region:497029-497038:-1
so has part: feature:497029-497038:-1:region

position:497029:-1
position: 497029
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497029-497038:-1:region

YGR001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AML1
gene: EFM5
locus tag: YGR001C
gene synonym: AML1
so part of: sequence
location: complement(<497133..>498034)
location: region:497133-498034:-1
so has part: feature:497133-498034:-1:exon
subclass of: SO_0000010

852884
type: Gene
SIO_000068: ncbigene

position:497133:-1
position: 497133
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498034:-1
position: 498034
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:497133-498034:-1:exon

YGR001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AML1
gene: EFM5
locus tag: YGR001C
gene synonym: AML1
product: protein-lysine N-methyltransferase
transcript id: NM_001181130.3
SIO_010081: YGR001C
subclass of: SO_0000673
so part of: YGR001C
location: complement(join(<497133..497365,497459..497937,498000..>498034))
location: region:497133-498034:-1
so has part: feature:498000-498034:-1:exon
so has part: feature:497459-497937:-1:exon
so has part: feature:497133-497365:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:498000-498034:-1:exon

position:498000:-1
position: 498000
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:497459-497937:-1:exon

position:497459:-1
position: 497459
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:497937:-1
position: 497937
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 3
SIO_000628: feature:497133-497365:-1:exon

position:497365:-1
position: 497365
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGR001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AML1
gene: EFM5
locus tag: YGR001C
gene synonym: AML1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:26545399]
experiment: EXISTENCE:direct assay:GO:0018023 peptidyl-lysine trimethylation [PMID:26545399]
experiment: EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:25446118]
experiment: EXISTENCE:mutant phenotype:GO:0018023 peptidyl-lysine trimethylation [PMID:25446118]
note: S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro
codon start: 1
product: protein-lysine N-methyltransferase
translation: MSDSDSDSDYELTLSANALAALEEFKREEQQHQEAFQKLYDETDEDFQKKKKEEGMKLFKEDWQLSQFWYSDDTAAILADAILEGADENTVIAIVSAPSVYAAIQKKPTNEIPTEHIYLFEFDKRFELLAGRDHFFFYDYNKPLDFSDEIKGKVDRLLIDPPFLNEDCQTKSSITAKCLLAPNDNSKTKKGVFKHRLISCTGERMSEVISKVYSDTRITTFLPEHSNGLSNEFRCYANFECSSWKFAS
SIO_010081: YGR001C
subclass of: SO_0000673
so part of: YGR001C
location: complement(join(497133..497365,497459..497937,498000..498034))
location: region:497133-498034:-1
so has part: feature:498000-498034:-1:exon
so has part: feature:497459-497937:-1:exon
so has part: feature:497133-497365:-1:exon

NP_011515.4
type: Protein
SIO_000068: ncbiprotein

S000003233
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:498000-498034:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:497459-497937:-1:exon

urn:…
SIO_000300: 3
SIO_000628: feature:497133-497365:-1:exon

YGR002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EAF2
alternative label: GOD1
gene: SWC4
locus tag: YGR002C
gene synonym: EAF2; GOD1
so part of: sequence
location: complement(<498476..>499906)
location: region:498476-499906:-1
so has part: feature:498476-499906:-1:exon
subclass of: SO_0000010

852885
type: Gene
SIO_000068: ncbigene

position:498476:-1
position: 498476
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:499906:-1
position: 499906
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498476-499906:-1:exon

YGR002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EAF2
alternative label: GOD1
gene: SWC4
locus tag: YGR002C
gene synonym: EAF2; GOD1
product: Swc4p
transcript id: NM_001181131.1
SIO_010081: YGR002C
subclass of: SO_0000673
so part of: YGR002C
location: complement(<498476..>499906)
location: region:498476-499906:-1
so has part: feature:498476-499906:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:498476-499906:-1:exon

YGR002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EAF2
alternative label: GOD1
gene: SWC4
locus tag: YGR002C
gene synonym: EAF2; GOD1
experiment: EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911|PMID:15353583]
experiment: EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15302830]
experiment: EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]
note: Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
codon start: 1
product: Swc4p
translation: MSSSDIFDVLNIKQKSRSPTNGQVSVPSSSAANRPKPQVTGMQRELFNLLGENQPPVVIKSGNNFKEKMLSTSKPSPWSFVEFKANNSVTLRHWVKGSKELIGDTPKESPYSKFNQHLSIPSFTKEEYEAFMNENEGTQKSVESEKNHNENFTNEKKDESKNSWSFEEIEYLFNLCKKYDLRWFLIFDRYSYNNSRTLEDLKEKFYYTCRNYFKASDPSNPLLSSLNFSAEKEIERKKYLQRLLSRSAAEIAEEEALVVESKKFEMAAKRTLAERESLLRLLDSPHSDQTITQYLTSQGMSQLYNALLADKTRKRKHDLNIPENPWMKQQQQFAQHRQLQQLNVKKSEVKENLSPKKTKRQRQEMQTALKRKSESAYAEQLLKDFNSDERKALGVITHGEKLSPGVYLRSTKLSTFKPALQNKILAILQELSLPSRPVMPSFDVMERQEELLKKINTLIDLKKHVDKYEAGMSITK
SIO_010081: YGR002C
subclass of: SO_0000673
so part of: YGR002C
location: complement(498476..499906)
location: region:498476-499906:-1
so has part: feature:498476-499906:-1:exon

NP_011516.1
type: Protein
SIO_000068: ncbiprotein

S000003234
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:498476-499906:-1:exon

YGR003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CUL3
locus tag: YGR003W
so part of: sequence
location: <500132..>502366
location: region:500132-502366:1
so has part: feature:500132-502366:1:exon
subclass of: SO_0000010

852886
type: Gene
SIO_000068: ncbigene

position:500132:1
position: 500132
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502366:1
position: 502366
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:500132-502366:1:exon

YGR003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CUL3
locus tag: YGR003W
product: cullin CUL3
transcript id: NM_001181132.1
SIO_010081: YGR003W
subclass of: SO_0000673
so part of: YGR003W
location: <500132..>502366
location: region:500132-502366:1
so has part: feature:500132-502366:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:500132-502366:1:exon

YGR003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CUL3
locus tag: YGR003W
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12676951|PMID:16675952]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17296727]
experiment: EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]
note: Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
codon start: 1
product: cullin CUL3
translation: MITNKKIKISVPEKLGLSEESFEESWETVKYAIDHIYSDDMADLSFEQVYKTIYTIVLNKKGPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKPNRCMEVYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMMETLHDNRDSFFLTDFEPVLISATEEYYNKAIDIELLTPIESLEKIRKLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEEKYRVTVIESIKSYINKNAINIPFNEGNRKKGQNAITWSSEIVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTKEKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSLVEIEKWMVQMIKKVLGTFFTSKLEIMLRDISLSSEMYQAFQHSTINSIEYLSFAPQVLTRTSWPFQSTNPIDEGISLPPRMSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQFNSGYYEISFSVYAGVIFLLFEDYEELTLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKKSSSSGNMKFSVNYFFSSPNRKVKVPVIACPLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSILKRSIQLLIEKEYIQRNADDPSYYHYLS
SIO_010081: YGR003W
subclass of: SO_0000673
so part of: YGR003W
location: 500132..502366
location: region:500132-502366:1
so has part: feature:500132-502366:1:exon

NP_011517.1
type: Protein
SIO_000068: ncbiprotein

S000003235
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:500132-502366:1:exon

YGR004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEX31
locus tag: YGR004W
so part of: sequence
location: <502938..>504326
location: region:502938-504326:1
so has part: feature:502938-504326:1:exon
subclass of: SO_0000010

852887
type: Gene
SIO_000068: ncbigene

position:502938:1
position: 502938
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:504326:1
position: 504326
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:502938-504326:1:exon

YGR004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEX31
locus tag: YGR004W
product: peroxisome biogenesis protein
transcript id: NM_001181133.1
SIO_010081: YGR004W
subclass of: SO_0000673
so part of: YGR004W
location: <502938..>504326
location: region:502938-504326:1
so has part: feature:502938-504326:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:502938-504326:1:exon

YGR004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEX31
locus tag: YGR004W
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:14617799]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:1900063 regulation of peroxisome organization [PMID:27872254]
experiment: EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:14617799]
note: Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication
codon start: 1
product: peroxisome biogenesis protein
translation: MSEINNENLEPTSSTVAESTESKNKHIRSALRKRRGKLSAQTYEEDQEAILSSPLLTSTPKTVSRSLVRLYPYLIVVDNFLSIITWSNDNVSANLLGIFLFTVCVLYFGFITRYFGHLMIVGIIWVYLLIDKHVQETMASCPSLDDIIHVMDRVSMKSSAVLSPITILSAQDVRRLLFTIAFLSPVYIFLTVFVLSPNYLMLIGGLYVLTYHSKLIRRMRRYLWKFRVVRLLVFFITGLDLGGPDNNRRLFASVNKKIRSFVWNEVGNTSNTKKTVLFKVALFENQRRWLGIGWTSTMLSYERASWTDEFLNTSPSPEVFTLPEEQSGMAWEWHDKDWMLDLTNDGIIQLPASAAKTKVKPGADEGFIYYDNTWNNPSATDTYKKYTRRRRWIRTATVTTTYDDEPTVEKATPNSHALKSEENNRVRKRKVSFSTANEVHIIPSSDSSKLIQISDVSMSPSL
SIO_010081: YGR004W
subclass of: SO_0000673
so part of: YGR004W
location: 502938..504326
location: region:502938-504326:1
so has part: feature:502938-504326:1:exon

NP_011518.1
type: Protein
SIO_000068: ncbiprotein

S000003236
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:502938-504326:1:exon

YGR005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TFG2
locus tag: YGR005C
so part of: sequence
location: complement(<504657..>505859)
location: region:504657-505859:-1
so has part: feature:504657-505859:-1:exon
subclass of: SO_0000010

852888
type: Gene
SIO_000068: ncbigene

position:504657:-1
position: 504657
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:505859:-1
position: 505859
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:504657-505859:-1:exon

YGR005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TFG2
locus tag: YGR005C
product: transcription factor IIF subunit TFG2
transcript id: NM_001181134.3
SIO_010081: YGR005C
subclass of: SO_0000673
so part of: YGR005C
location: complement(<504657..>505859)
location: region:504657-505859:-1
so has part: feature:504657-505859:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:504657-505859:-1:exon

YGR005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TFG2
locus tag: YGR005C
experiment: EXISTENCE:curator inference:GO:0001111 RNA polymerase II promoter clearance [PMID:7995524]
experiment: EXISTENCE:curator inference:GO:0001139 RNA polymerase II complex recruiting activity [PMID:7995524]
experiment: EXISTENCE:curator inference:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:7995524]
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:14749386]
experiment: EXISTENCE:direct assay:GO:0005674 transcription factor TFIIF complex [PMID:12242279|PMID:7995524]
experiment: EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:1331084|PMID:18362165]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:18362165]
experiment: EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:15572698|PMID:20033062]
note: TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
codon start: 1
product: transcription factor IIF subunit TFG2
translation: MSSGSAGAPALSNNSTNSVAKEKSGNISGDEYLSQEEEVFDGNDIENNETKVYEESLDLDLERSNRQVWLVRLPMFLAEKWRDRNNLHGQELGKIRINKDGSKITLLLNENDNDSIPHEYDLELTKKVVENEYVFTEQNLKKYQQRKKELEADPEKQRQAYLKKQEREEELKKKQQQQKRRNNRKKFNHRVMTDRDGRDRYIPYVKTIPKKTAIVGTVCHECQVMPSMNDPNYHKIVEQRRNIVKLNNKERITTLDETVGVTMSHTGMSMRSDNSNFLKVGREKAKSNIKSIRMPKKEILDYLFKLFDEYDYWSLKGLKERTRQPEAHLKECLDKVATLVKKGPYAFKYTLRPEYKKLKEEERKATLGELADEQTGSAGDNAQGDAEADLEDEIEMEDVV
SIO_010081: YGR005C
subclass of: SO_0000673
so part of: YGR005C
location: complement(504657..505859)
location: region:504657-505859:-1
so has part: feature:504657-505859:-1:exon

NP_011519.3
type: Protein
SIO_000068: ncbiprotein

S000003237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:504657-505859:-1:exon

YGR006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP18
locus tag: YGR006W
so part of: sequence
location: <506070..>506825
location: region:506070-506825:1
so has part: feature:506070-506825:1:exon
subclass of: SO_0000010

852889
type: Gene
SIO_000068: ncbigene

position:506070:1
position: 506070
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:506825:1
position: 506825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506070-506825:1:exon

YGR006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP18
locus tag: YGR006W
product: mRNA splicing protein PRP18
transcript id: NM_001181135.1
SIO_010081: YGR006W
subclass of: SO_0000673
so part of: YGR006W
location: <506070..>506825
location: region:506070-506825:1
so has part: feature:506070-506825:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506070-506825:1:exon

YGR006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP18
locus tag: YGR006W
experiment: EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:8474454]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:8474454]
experiment: EXISTENCE:direct assay:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]
experiment: EXISTENCE:genetic interaction:GO:0000386 second spliceosomal transesterification activity [PMID:17626844]
experiment: EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:14718167]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12403466]
experiment: EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:14718167]
note: Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p
codon start: 1
product: mRNA splicing protein PRP18
translation: MDLDLASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQESTDEENLSDNQSDDIRTTISKLENRPERIQEAIAQDKTISVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKASLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEINLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERTRLWITSIKRLITFEEWYTSNHDSLA
SIO_010081: YGR006W
subclass of: SO_0000673
so part of: YGR006W
location: 506070..506825
location: region:506070-506825:1
so has part: feature:506070-506825:1:exon

NP_011520.2
type: Protein
SIO_000068: ncbiprotein

S000003238
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506070-506825:1:exon

YGR007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MUQ1
gene: ECT1
locus tag: YGR007W
gene synonym: MUQ1
so part of: sequence
location: <506969..>507940
location: region:506969-507940:1
so has part: feature:506969-507940:1:exon
subclass of: SO_0000010

852890
type: Gene
SIO_000068: ncbigene

position:506969:1
position: 506969
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:507940:1
position: 507940
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:506969-507940:1:exon

YGR007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MUQ1
gene: ECT1
locus tag: YGR007W
gene synonym: MUQ1
product: ethanolamine-phosphate cytidylyltransferase
transcript id: NM_001181136.1
SIO_010081: YGR007W
subclass of: SO_0000673
so part of: YGR007W
location: <506969..>507940
location: region:506969-507940:1
so has part: feature:506969-507940:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:506969-507940:1:exon

YGR007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MUQ1
gene: ECT1
locus tag: YGR007W
gene synonym: MUQ1
EC number: 2.7.7.14
experiment: EXISTENCE:direct assay:GO:0004306 ethanolamine-phosphate cytidylyltransferase activity [PMID:8982874]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004306 ethanolamine-phosphate cytidylyltransferase activity [PMID:8982874]
experiment: EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:8982874]
note: Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2
codon start: 1
product: ethanolamine-phosphate cytidylyltransferase
translation: MTVNLDPDKVWIDGCFDFTHHGHAGAILQARRTVSKENGKLFCGVHTDEDIQHNKGTPVMNSSERYEHTRSNRWCSEVVEAAPYVTDPNWMDKYQCQYVVHGDDITIDANGEDCYKLVKEMGRFKVVKRTYGVSTTEIIHRILTKKSLPPTHPDYYPTTQELSFYSVAQDAVSKHCYVFQRDLDNVLVNGGYKFDAEDCVYVDGDFDLFHMGDIDQLRKLKMDLHPDKKLIVGITTSDYSSTIMTMKERVLSVLSCKYVDAVIIDADATSMSQYNCEKYHIGTAVLTAAGKFSEYLTKELIVKRVESQREVYIARNQKKGMSI
SIO_010081: YGR007W
subclass of: SO_0000673
so part of: YGR007W
location: 506969..507940
location: region:506969-507940:1
so has part: feature:506969-507940:1:exon

NP_011521.1
type: Protein
SIO_000068: ncbiprotein

S000003239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:506969-507940:1:exon

YGR008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: STF2
locus tag: YGR008C
so part of: sequence
location: complement(<508110..>508364)
location: region:508110-508364:-1
so has part: feature:508110-508364:-1:exon
subclass of: SO_0000010

852891
type: Gene
SIO_000068: ncbigene

position:508110:-1
position: 508110
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:508364:-1
position: 508364
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:508110-508364:-1:exon

YGR008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: STF2
locus tag: YGR008C
product: ATPase-stabilizing factor family protein
transcript id: NM_001181137.1
SIO_010081: YGR008C
subclass of: SO_0000673
so part of: YGR008C
location: complement(<508110..>508364)
location: region:508110-508364:-1
so has part: feature:508110-508364:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:508110-508364:-1:exon

YGR008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: STF2
locus tag: YGR008C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22442684]
experiment: EXISTENCE:mutant phenotype:GO:0071465 cellular response to desiccation [PMID:22442684]
note: Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication
codon start: 1
product: ATPase-stabilizing factor family protein
translation: MTRTNKWTEREGKADPKYFSHTGNYGESPNHIKKQGSGKGNWGKPGDEIDDLIDNGEIPPVFKKDRRGSNLQSHEQKFENVQKE
SIO_010081: YGR008C
subclass of: SO_0000673
so part of: YGR008C
location: complement(508110..508364)
location: region:508110-508364:-1
so has part: feature:508110-508364:-1:exon

NP_011522.1
type: Protein
SIO_000068: ncbiprotein

S000003240
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:508110-508364:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS720; Autonomously Replicating Sequence
so part of: sequence
location: 508729..508977
location: region:508729-508977:1
so has part: feature:508729-508977:1:region

S000118460
type: SGD
SIO_000068: sgd

position:508729:1
position: 508729
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:508977:1
position: 508977
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:508729-508977:1:region

YGR009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HSS7
gene: SEC9
locus tag: YGR009C
gene synonym: HSS7
so part of: sequence
location: complement(<509047..>511002)
location: region:509047-511002:-1
so has part: feature:509047-511002:-1:exon
subclass of: SO_0000010

852892
type: Gene
SIO_000068: ncbigene

position:509047:-1
position: 509047
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:511002:-1
position: 511002
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:509047-511002:-1:exon

YGR009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HSS7
gene: SEC9
locus tag: YGR009C
gene synonym: HSS7
product: Sec9p
transcript id: NM_001181138.3
SIO_010081: YGR009C
subclass of: SO_0000673
so part of: YGR009C
location: complement(<509047..>511002)
location: region:509047-511002:-1
so has part: feature:509047-511002:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:509047-511002:-1:exon

YGR009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HSS7
gene: SEC9
locus tag: YGR009C
gene synonym: HSS7
experiment: EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:16339720]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]
experiment: EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9195974]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]
note: t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog
codon start: 1
product: Sec9p
translation: MGLKKFFKIKPPEEATPEQNKDTLMELGISVKNPSKKRKEKFAAYGKFANDKAEDKVYAPPGYEQYARPQDELEDLNASPLDANANEATAGSNRGSSGTQDLGNGAESNSMQDPYAIENDDYRYDDDPYARFQANKSNGRGSVNAAPYGDYGGGYNGTSLNSYNNDGPYSNQNTSNSWVNANGRNSLNHSNSTLNVGPSRQTRQPPVSTSTNSLSLDQRSPLANPMQEKRNPYADMNSYGGAYDSNTNRSSGTRQGSSKNANPYASMANDSYSNGNLNRSANPYSSRSVRQPQSQQAPMTYTPSFIASDEAARNSEVDLNEEPRTGEFDFEEVYADKSAENRAALDEPDLNAVMTNEDSIDLNASEVDHSSRQQQQQQWFMDEQQQQQQHFNATNNQYGDQRGYKTFEEIQKEEEARQQQEEDEAVDEIKQEIKFTKQSSVASTRNTLKMAQDAERAGMNTLGMLGHQSEQLNNVEGNLDLMKVQNKVADEKVAELKKLNRSILAVHVSNPFNSKRRRREREEQLKNRKIEEKLMREQTSQQLSQSTQRIEGAMNANNNISEVRERYQRKNVLEKAKRYQFENDEEDDEMELEIDRNLDQIQQVSNRLKKMALTTGKELDSQQKRLNNIEESTDDLDINLHMNTNRLAGIR
SIO_010081: YGR009C
subclass of: SO_0000673
so part of: YGR009C
location: complement(509047..511002)
location: region:509047-511002:-1
so has part: feature:509047-511002:-1:exon

NP_011523.3
type: Protein
SIO_000068: ncbiprotein

S000003241
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:509047-511002:-1:exon

YGR010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NMA2
locus tag: YGR010W
so part of: sequence
location: <511545..>512732
location: region:511545-512732:1
so has part: feature:511545-512732:1:exon
subclass of: SO_0000010

852893
type: Gene
SIO_000068: ncbigene

position:511545:1
position: 511545
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:512732:1
position: 512732
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:511545-512732:1:exon

YGR010W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NMA2
locus tag: YGR010W
product: nicotinamide-nucleotide adenylyltransferase NMA2
transcript id: NM_001181139.1
SIO_010081: YGR010W
subclass of: SO_0000673
so part of: YGR010W
location: <511545..>512732
location: region:511545-512732:1
so has part: feature:511545-512732:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:511545-512732:1:exon

YGR010W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NMA2
locus tag: YGR010W
EC number: 2.7.7.1
EC number: 2.7.7.18
experiment: EXISTENCE:direct assay:GO:0000309 nicotinamide-nucleotide adenylyltransferase activity [PMID:21621500]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11884393]
experiment: EXISTENCE:direct assay:GO:0009435 NAD biosynthetic process [PMID:21621500]
note: Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication
codon start: 1
product: nicotinamide-nucleotide adenylyltransferase NMA2
translation: MDPTKAPDFKPPQPNEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTLSSRKKNANSSNRMDHIPLNTSDFQPLSRDVSSEEESEGQSNGIDATLQDVTMTGNLGVLKSQIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMFEMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWESLQSSYTRTAKVLDHFNHEINIKRGGIMTVDGEKMGVKIMLLAGGDLIESMGEPHVWADSDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE
SIO_010081: YGR010W
subclass of: SO_0000673
so part of: YGR010W
location: 511545..512732
location: region:511545-512732:1
so has part: feature:511545-512732:1:exon

NP_011524.1
type: Protein
SIO_000068: ncbiprotein

S000003242
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:511545-512732:1:exon

YGR012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCY1
locus tag: YGR012W
so part of: sequence
location: <513159..>514340
location: region:513159-514340:1
so has part: feature:513159-514340:1:exon
subclass of: SO_0000010

852895
type: Gene
SIO_000068: ncbigene

position:513159:1
position: 513159
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:514340:1
position: 514340
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:513159-514340:1:exon

YGR012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCY1
locus tag: YGR012W
product: putative cysteine synthase
transcript id: NM_001181141.1
SIO_010081: YGR012W
subclass of: SO_0000673
so part of: YGR012W
location: <513159..>514340
location: region:513159-514340:1
so has part: feature:513159-514340:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:513159-514340:1:exon

YGR012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCY1
locus tag: YGR012W
EC number: 2.5.1.47
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
note: Putative cysteine synthase; localized to the mitochondrial outer membrane
codon start: 1
product: putative cysteine synthase
translation: MSCSQNKTSVSLAWRECISIASVLIGAYASYKYYKLFKTRDIPRPKEGVEELIGNTPLVKIRSLTKATGVNIYAKLELCNPAGSAKDRVALNIIKTAEELGELVRGEPGWVFEGTSGSTGISIAVVCNALGYRAHISLPDDTSLEKLALLESLGATVNKVKPASIVDPNQYVNAAKKACNELKKSGNGIRAVFADQFENEANWKVHYQTTGPEIAHQTKGNIDAFIAGCGTGGTITGVAKFLKERAKIPCHVVLADPQGSGFYNRVNYGVMYDYVEKEGTRRRHQVDTIVEGIGLNRITHNFHMGEKFIDESIRVNDNQAIRMAKYLSVNDGLFVGSSTAINAVAAIQVAKTLPHGSNIVIIACDSGSRHLSKFWKEAKEIDHDVSLEEVINI
SIO_010081: YGR012W
subclass of: SO_0000673
so part of: YGR012W
location: 513159..514340
location: region:513159-514340:1
so has part: feature:513159-514340:1:exon

NP_011526.1
type: Protein
SIO_000068: ncbiprotein

S000003244
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:513159-514340:1:exon

YGR013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNU71
locus tag: YGR013W
so part of: sequence
location: <514554..>516416
location: region:514554-516416:1
so has part: feature:514554-516416:1:exon
subclass of: SO_0000010

852896
type: Gene
SIO_000068: ncbigene

position:514554:1
position: 514554
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:516416:1
position: 516416
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:514554-516416:1:exon

YGR013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNU71
locus tag: YGR013W
product: Snu71p
transcript id: NM_001181142.1
SIO_010081: YGR013W
subclass of: SO_0000673
so part of: YGR013W
location: <514554..>516416
location: region:514554-516416:1
so has part: feature:514554-516416:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:514554-516416:1:exon

YGR013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNU71
locus tag: YGR013W
experiment: EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
note: Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
codon start: 1
product: Snu71p
translation: MRDIVFVSPQLYLSSQEGWKSDSAKSGFIPILKNDLQRFQDSLKHIVDARNSLSETLLNSNDDGSIHNSDQNTGLNKDKEASIADNNSANKCATSSSRYQELKQFLPISLDQQIHTVSLQGVSSSFSRGQIESLLDHCLNLALTETQSNSALKVEAWSSFSSFLDTQDIFIRFSKVDEDEAFVNTLNYCKALFAFIRKLHEDFKIELHLDLNTKEYVEDRTGTIPSVKPEKASEFYSVFKNIEDQTDERNSKKEQLDDSSTQYKVDTNTLSDLPSDALDQLCKDIIEFRTKVVSIEKEKKMKSTYEESRRQRHQMQKVFDQIRKNHSGAKGSANTEEEDTNMEDEDEEDDTEDDLALEKRKEERDLEESNRRYEDMLHQLHSNTEPKIKSIRADIMSAENYEEHLEKNRSLYLKELLHLANDVHYDHHRSFKEQEERRDEEDRAKNGNAKELAPIQLSDGKAISAGKAAAITLPEGTVKSENYNADKNVSESSEHVKIKFDFKKAIDHSVESSSEDEGYRESELPPTKPSERSAAEDRLPFTADELNIRLTNLKESRYVDELVREFLGVYEDELVEYILENIRVNQSKQALLNELRETFDEDGETIADRLWSRKEFRLGT
SIO_010081: YGR013W
subclass of: SO_0000673
so part of: YGR013W
location: 514554..516416
location: region:514554-516416:1
so has part: feature:514554-516416:1:exon

NP_011527.1
type: Protein
SIO_000068: ncbiprotein

S000003245
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:514554-516416:1:exon

YGR014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MSB2
locus tag: YGR014W
so part of: sequence
location: <516943..>520863
location: region:516943-520863:1
so has part: feature:516943-520863:1:exon
subclass of: SO_0000010

852897
type: Gene
SIO_000068: ncbigene

position:516943:1
position: 516943
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520863:1
position: 520863
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:516943-520863:1:exon

YGR014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MSB2
locus tag: YGR014W
product: Msb2p
transcript id: NM_001181143.3
SIO_010081: YGR014W
subclass of: SO_0000673
so part of: YGR014W
location: <516943..>520863
location: region:516943-520863:1
so has part: feature:516943-520863:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:516943-520863:1:exon

YGR014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MSB2
locus tag: YGR014W
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:18591427]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:15256499]
experiment: EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:17627274]
experiment: EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:17627274]
experiment: EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:2690082]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:15256499|PMID:18591427]
experiment: EXISTENCE:mutant phenotype:GO:0005034 osmosensor activity [PMID:12052881]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12052881]
experiment: EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:12052881]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:19439450]
note: Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate
codon start: 1
product: Msb2p
translation: MQFPFACLLSTLVISGSLARASPFDFIFGNGTQQAQSQSESQGQVSFTNEASQDSSTTSLVTAYSQGVHSHQSATIVSATISSLPSTWYDASSTSQTSVSYASQESDYAVNQNSWSASTNQLPSTSTTSYYAPTFSTSADFAASSVNAASDVSTASVPIDTSANSIPFTTTSNIETTTSAPLTSDTPLISTSTMSAADNVFSSANPISASLTTTDSSESFDQTSTAGAIPVQSSADFSSSSEILVQSSADFSSPSSPTTTDISLSAAPLQTSESSSFTTASAALPVSSTDVDGSSASPVVSMSAAGQIASSSSTDNPTMSETFSLTSTEVDGSDVSSTVSALLSAPFLQTSTSNSFSIVSPSVSFVPSQSSSDVASSSTANVVSSSFSDIPPQTSTSGSVVSVAQSASALAFQSSTEVYGASASSTMSSLLSTTSLQSTTLDSSSLASSSASSSDLTDYGVSSTASIPLLSASEQASTSSSFSVVSPSVSFVPSQSSSDVASTSAPSVVSSSFSYTSLQAGGSSMTNPSSSTIVYSSSTGSSEESAASTASATLSGSSSTYMAGNLQSQPPSTSSLLSESQATSTSAVLASSSVSTTSPYTTAGGASTEASSLISSTSAETSQVSYSQSTTALQTSSFASSSTTEGSETSSQGFSTSSVLVQMPSSISSEFSPSQTTTQMNSASSSSQYTISSTGILSQVSDTSVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTPVSYTTSSSSVSQVSDTSVPSTSSRSSVSQVSDTPVPSTSSRSSVSQTSSSLQPTTTSSQRFTISTHGALSESSSVSQQASEITSSINATASEYHSIQTTAATQSTTLSFTDANSSSASAPLEVATSTPTPSSKASSLLLTPSTSSLSQVATNTNVQTSLTTESTTVLEPSTTNSSSTFSLVTSSDNNWWIPTELITQAPEAASTASSTVGGTQTMTLPHAIAAATQVPEPEGYTLITIGFKKALNYEFVVSEPKSSAQIFGYLPEALNTPFKNVFTNITVLQIVPLQDDSLNYLVSVAEVYFPTAEIEELSNLITNSSSAFYTDGMGTAKSMAAMVDSSIPLTGLLHDSNSNSGGSSDGSSSSNSNSGSSGSGSNSNSGVSSSSGNSYQDAGTLEYSSKSNSNVSTSSKSKKKIIGLVIGVVVGGCLYILFMIFAFKYIIRRRIQSQEIIKNPEISSISSSEFGGEKNYNNEKRMSVQESITQSMRIQNWMDDSYYGHGLTNNDSTPTRHNTSSSIPKISRPIASQNSLGWNEV
SIO_010081: YGR014W
subclass of: SO_0000673
so part of: YGR014W
location: 516943..520863
location: region:516943-520863:1
so has part: feature:516943-520863:1:exon

NP_011528.3
type: Protein
SIO_000068: ncbiprotein

S000003246
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:516943-520863:1:exon

YGR015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EAT1
locus tag: YGR015C
so part of: sequence
location: complement(<521090..>522076)
location: region:521090-522076:-1
so has part: feature:521090-522076:-1:exon
subclass of: SO_0000010

852898
type: Gene
SIO_000068: ncbigene

position:521090:-1
position: 521090
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522076:-1
position: 522076
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:521090-522076:-1:exon

YGR015C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EAT1
locus tag: YGR015C
product: putative hydrolase
transcript id: NM_001181144.1
SIO_010081: YGR015C
subclass of: SO_0000673
so part of: YGR015C
location: complement(<521090..>522076)
location: region:521090-522076:-1
so has part: feature:521090-522076:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:521090-522076:-1:exon

YGR015C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EAT1
locus tag: YGR015C
EC number: 2.3.1.268
EC number: 3.1.2.1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016453 C-acetyltransferase activity [PMID:28356220]
note: Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
codon start: 1
product: putative hydrolase
translation: MSRLAHNKALPYKIIVDLSFHRTRLPSDVSSLIKFEQRPAIINIHGLLGSHVMFHSLNKLLSRKLDADIFSVDVRNHGISPKAIPYDYTTLTNDLIYFIETHIGLERPIYLLGFSMGGKIALLTTLYKNINIRKCISIDLPPYETPELDPMILQNYDLIMRIIRRDVKILRGSPSWQKKVLELFKSLECNKRKCGGAVALYFANGFLSVKSNNVHQAQLHYEQQQHDPYINYSMPLSSMPNLLDEVKKWPDLSNQRDFFQKGTASRKVLFMKGLQSNFINNDYSLLRYNFPCADVREFNTGHNLLLENPEDSFKCILNFFAEETLDFE
SIO_010081: YGR015C
subclass of: SO_0000673
so part of: YGR015C
location: complement(521090..522076)
location: region:521090-522076:-1
so has part: feature:521090-522076:-1:exon

NP_011529.1
type: Protein
SIO_000068: ncbiprotein

S000003247
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:521090-522076:-1:exon

YGR016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR016W
so part of: sequence
location: <522261..>522833
location: region:522261-522833:1
so has part: feature:522261-522833:1:exon
subclass of: SO_0000010

852899
type: Gene
SIO_000068: ncbigene

position:522261:1
position: 522261
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522833:1
position: 522833
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:522261-522833:1:exon

YGR016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR016W
product: uncharacterized protein
transcript id: NM_001181145.1
SIO_010081: YGR016W
subclass of: SO_0000673
so part of: YGR016W
location: <522261..>522833
location: region:522261-522833:1
so has part: feature:522261-522833:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:522261-522833:1:exon

YGR016W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR016W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
codon start: 1
product: uncharacterized protein
translation: MSRLRRFNRKILSLSSDYTHDGESDQEDVSILPLDTEEQEELIQKFETNAHITNKLYINLLSILYLLYGGLLMILVRKSRGYIKLALLAGANSLICSCITLRYDIVNDYLLFKKFKLRVSNFSINIINIILLVLMAWISFNHVVEDKKTVLCLQVPMFLFWVAVLVKRWARNIEDEIADLRCLKYKYKNA
SIO_010081: YGR016W
subclass of: SO_0000673
so part of: YGR016W
location: 522261..522833
location: region:522261-522833:1
so has part: feature:522261-522833:1:exon

NP_011530.1
type: Protein
SIO_000068: ncbiprotein

S000003248
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:522261-522833:1:exon

YGR017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR017W
so part of: sequence
location: <523787..>524680
location: region:523787-524680:1
so has part: feature:523787-524680:1:exon
subclass of: SO_0000010

852900
type: Gene
SIO_000068: ncbigene

position:523787:1
position: 523787
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524680:1
position: 524680
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523787-524680:1:exon

YGR017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR017W
product: uncharacterized protein
transcript id: NM_001181146.1
SIO_010081: YGR017W
subclass of: SO_0000673
so part of: YGR017W
location: <523787..>524680
location: region:523787-524680:1
so has part: feature:523787-524680:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523787-524680:1:exon

YGR017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR017W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Pyridoxamine-phosphate oxidase-related protein (PNPO-RP); deletion causes significant increase in 4.5.6-NADH3
codon start: 1
product: uncharacterized protein
translation: MSHQMAPWIPMFIQSCKNNTEPFVSFQFATVDELTNKPRCRTVVFRDFLFHDKRTNVLTFNTDMRSSKITESFITPNSNNSSDSKRCETPFFEACFYFPETWEQYRFSGQCFTISKQFKKIPAEIVTKYDIFSPRFSETNDDSTDEEIDTPINDDDDDDKNNDADNNDINEDNKLIESIENDEHHEDEDDYYPQPQEWEAELLRQWSSLSRHTKSLYRKPAPGQKLTSETSKQLDKLHRGVDGAKEDAGLENFGIVCLCVDSVDFLNLKEGRGGERWIFQKTDGKDEDLWEEQEVCP
SIO_010081: YGR017W
subclass of: SO_0000673
so part of: YGR017W
location: 523787..524680
location: region:523787-524680:1
so has part: feature:523787-524680:1:exon

NP_011531.1
type: Protein
SIO_000068: ncbiprotein

S000003249
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523787-524680:1:exon

YGR018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR018C
so part of: sequence
location: complement(<524365..>524694)
location: region:524365-524694:-1
so has part: feature:524365-524694:-1:exon
subclass of: SO_0000010

852901
type: Gene
SIO_000068: ncbigene

position:524365:-1
position: 524365
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:524694:-1
position: 524694
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:524365-524694:-1:exon

YGR018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR018C
product: uncharacterized protein
transcript id: NM_001270747.1
SIO_010081: YGR018C
subclass of: SO_0000673
so part of: YGR018C
location: complement(<524365..>524694)
location: region:524365-524694:-1
so has part: feature:524365-524694:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:524365-524694:-1:exon

YGR018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR018C
note: hypothetical protein; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
codon start: 1
product: uncharacterized protein
translation: MIDISHGHTSCSSHRSSSLPSVFWKIHLSPPLPSFKFKKSTESTQRQTIPKFSSPASSLAPSTPLWSLSSCLLVSEVSFWPGAGFLYNDLVCLDREDHCLSNSASHSCG
SIO_010081: YGR018C
subclass of: SO_0000673
so part of: YGR018C
location: complement(524365..524694)
location: region:524365-524694:-1
so has part: feature:524365-524694:-1:exon

NP_001257676.1
type: Protein
SIO_000068: ncbiprotein

S000003250
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:524365-524694:-1:exon

YGR019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UGA1
locus tag: YGR019W
so part of: sequence
location: <525229..>526644
location: region:525229-526644:1
so has part: feature:525229-526644:1:exon
subclass of: SO_0000010

852902
type: Gene
SIO_000068: ncbigene

position:525229:1
position: 525229
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:526644:1
position: 526644
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525229-526644:1:exon

YGR019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UGA1
locus tag: YGR019W
product: 4-aminobutyrate transaminase
transcript id: NM_001181148.3
SIO_010081: YGR019W
subclass of: SO_0000673
so part of: YGR019W
location: <525229..>526644
location: region:525229-526644:1
so has part: feature:525229-526644:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525229-526644:1:exon

YGR019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UGA1
locus tag: YGR019W
EC number: 2.6.1.19
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23740823]
experiment: EXISTENCE:mutant phenotype:GO:0003867 4-aminobutyrate transaminase activity [PMID:3888627]
experiment: EXISTENCE:mutant phenotype:GO:0009450 gamma-aminobutyric acid catabolic process [PMID:3888627]
note: Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
codon start: 1
product: 4-aminobutyrate transaminase
translation: MSICEQYYPEEPTKPTVKTESIPGPESQKQLKELGEVFDTRPAYFLADYEKSLGNYITDVDGNTYLDLYAQISSIALGYNNPALIKAAQSPEMIRALVDRPALGNFPSKDLDKILKQILKSAPKGQDHVWSGLSGADANELAFKAAFIYYRAKQRGYDADFSEKENLSVMDNDAPGAPHLAVLSFKRAFHGRLFASGSTTCSKPIHKLDFPAFHWPHAEYPSYQYPLDENSDANRKEDDHCLAIVEELIKTWSIPVAALIIEPIQSEGGDNHASKYFLQKLRDITLKYNVVYIIDEVQTGVGATGKLWCHEYADIQPPVDLVTFSKKFQSAGYFFHDPKFIPNKPYRQFNTWCGEPARMIIAGAIGQEISDKKLTEQCSRVGDYLFKKLEGLQKKYPENFQNLRGKGRGTFIAWDLPTGEKRDLLLKKLKLNGCNVGGCAVHAVRLRPSLTFEEKHADIFIEALAKSVNEL
SIO_010081: YGR019W
subclass of: SO_0000673
so part of: YGR019W
location: 525229..526644
location: region:525229-526644:1
so has part: feature:525229-526644:1:exon

NP_011533.3
type: Protein
SIO_000068: ncbiprotein

S000003251
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525229-526644:1:exon

YGR020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VMA7
locus tag: YGR020C
so part of: sequence
location: complement(<526973..>527329)
location: region:526973-527329:-1
so has part: feature:526973-527329:-1:exon
subclass of: SO_0000010

852903
type: Gene
SIO_000068: ncbigene

position:526973:-1
position: 526973
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:527329:-1
position: 527329
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:526973-527329:-1:exon

YGR020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VMA7
locus tag: YGR020C
product: H(+)-transporting V1 sector ATPase subunit F
transcript id: NM_001181149.1
SIO_010081: YGR020C
subclass of: SO_0000673
so part of: YGR020C
location: complement(<526973..>527329)
location: region:526973-527329:-1
so has part: feature:526973-527329:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:526973-527329:-1:exon

YGR020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VMA7
locus tag: YGR020C
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
note: Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits
codon start: 1
product: H(+)-transporting V1 sector ATPase subunit F
translation: MAEKRTLIAVIADEDTTTGLLLAGIGQITPETQEKNFFVYQEGKTTKEEITDKFNHFTEERDDIAILLINQHIAENIRARVDSFTNAFPAILEIPSKDHPYDPEKDSVLKRVRKLFGE
SIO_010081: YGR020C
subclass of: SO_0000673
so part of: YGR020C
location: complement(526973..527329)
location: region:526973-527329:-1
so has part: feature:526973-527329:-1:exon

NP_011534.1
type: Protein
SIO_000068: ncbiprotein

S000003252
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:526973-527329:-1:exon

YGR021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DPC29
locus tag: YGR021W
so part of: sequence
location: <527632..>528504
location: region:527632-528504:1
so has part: feature:527632-528504:1:exon
subclass of: SO_0000010

852904
type: Gene
SIO_000068: ncbigene

position:527632:1
position: 527632
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:528504:1
position: 528504
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:527632-528504:1:exon

YGR021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DPC29
locus tag: YGR021W
product: Dpc29p
transcript id: NM_001181150.1
SIO_010081: YGR021W
subclass of: SO_0000673
so part of: YGR021W
location: <527632..>528504
location: region:527632-528504:1
so has part: feature:527632-528504:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:527632-528504:1:exon

YGR021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DPC29
locus tag: YGR021W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
note: Putative mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Dpc29p
translation: MLVRNRYLGELLKNSRSFSVLNSSVRSGHNKWSTIKHGKAKNDAERNKINNKFANQIAMSVKLGNGITDPSMNIRLATSIELANKNNVSKKVIENAIRKASGSSASGKDSNASELCVYEGMGPGGVAIVVEALTDNKNRTIGLIRSAFNKANGSMTPTLFFFDKKGYVTMVPPKMLDTEDKVLESVLEIQGIEDIAPVQEDAEDLECDTETETTGQTYEAVMEPADTNKVAALLKERGFHIRDLGIGYNAKPDMEVFVQGDETLEKLQKLTTALEDIDEVTSLYTNASNA
SIO_010081: YGR021W
subclass of: SO_0000673
so part of: YGR021W
location: 527632..528504
location: region:527632-528504:1
so has part: feature:527632-528504:1:exon

NP_011535.1
type: Protein
SIO_000068: ncbiprotein

S000003253
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:527632-528504:1:exon

YGR023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTL1
locus tag: YGR023W
so part of: sequence
location: <529264..>530919
location: region:529264-530919:1
so has part: feature:529264-530919:1:exon
subclass of: SO_0000010

852905
type: Gene
SIO_000068: ncbigene

position:529264:1
position: 529264
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:530919:1
position: 530919
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:529264-530919:1:exon

YGR023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTL1
locus tag: YGR023W
product: Mtl1p
transcript id: NM_001181152.1
SIO_010081: YGR023W
subclass of: SO_0000673
so part of: YGR023W
location: <529264..>530919
location: region:529264-530919:1
so has part: feature:529264-530919:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:529264-530919:1:exon

YGR023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTL1
locus tag: YGR023W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:20388713]
experiment: EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:20388713]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10330137]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15637049|PMID:20388713]
experiment: EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:20388713]
note: Transmembrane sensor of the cell wall integrity pathway (CWI); involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; structurally and functionally similar to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication
codon start: 1
product: Mtl1p
translation: MASCNPTRKKSSASSLSMWRTILMALTTLPLSVLSQELVPANSTTSSTAPSITSLSAVESFTSSTDATSSASLSTPSIASVSFTSFPQSSSLLTLSSTLSSELSSSSMQVSSSSTSSSSSEVTSSSSSSSISPSSSSSTIISSSSSLPTFTVASTSSTVASSTLSTSSSLVISTSSSTFTFSSESSSSLISSSISTSVSTSSVYVPSSSTSSPPSSSSELTSSSYSSSSSSSTLFSYSSSFSSSSSSSSSSSSSSSSSSSSSSSYFTLSTSSSSSIYSSSSYPSFSSSSSSNPTSSITSTSASSSITPASEYSNLAKTITSIIEGQTILSNYYTTITYSPTASASSGKNSHHSGLSKKNRNIIIGCVVGIGAPLILILLILIYMFCVQPKKTDFIDSDGKIVTAYRSNIFTKIWYFLLGKKIGETERFSSDSPIGSNNIQNFGDIDPEDILNNDNPYTPKHTNVEGYDDDDDDDANDENLSSNFHNRGIDDQYSPTKSASYSMSNSNSQDYNDADEVMHDENIHRVYDDSEASIDENYYTKPNNGLNITNY
SIO_010081: YGR023W
subclass of: SO_0000673
so part of: YGR023W
location: 529264..530919
location: region:529264-530919:1
so has part: feature:529264-530919:1:exon

NP_011537.1
type: Protein
SIO_000068: ncbiprotein

S000003255
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:529264-530919:1:exon

YNCG0021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0021W
so part of: sequence
location: 531610..531681
location: region:531610-531681:1
so has part: feature:531610-531681:1:exon
subclass of: SO_0000663

852907
type: Gene
SIO_000068: ncbigene

position:531610:1
position: 531610
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:531681:1
position: 531681
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:531610-531681:1:exon

YNCG0021W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0021W
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0021W
subclass of: SO_0000673
so part of: YNCG0021W
location: 531610..531681
location: region:531610-531681:1
so has part: feature:531610-531681:1:exon

S000006532
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:531610-531681:1:exon

YGR024C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THG1
locus tag: YGR024C
so part of: sequence
location: complement(<531883..>532596)
location: region:531883-532596:-1
so has part: feature:531883-532596:-1:exon
subclass of: SO_0000010

852908
type: Gene
SIO_000068: ncbigene

position:531883:-1
position: 531883
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:532596:-1
position: 532596
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:531883-532596:-1:exon

YGR024C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THG1
locus tag: YGR024C
product: tRNA guanylyltransferase
transcript id: NM_001181153.3
SIO_010081: YGR024C
subclass of: SO_0000673
so part of: YGR024C
location: complement(<531883..>532596)
location: region:531883-532596:-1
so has part: feature:531883-532596:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:531883-532596:-1:exon

YGR024C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THG1
locus tag: YGR024C
EC number: 2.7.7.79
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:14633974]
experiment: EXISTENCE:direct assay:GO:0008193 tRNA guanylyltransferase activity [PMID:14633974]
note: tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
codon start: 1
product: tRNA guanylyltransferase
translation: MANSKFGYVRQFETHDVILPQCYIVVRIDGKKFHEFSKFYEFAKPNDENALKLMNACAKNLVLKYKNDIILAFGESDEYSFILKSSTTLFNRRKDKLATLFGSFFTSNYVALWAKFFPEKPLNIKHLPYFDSRCVAYPNLQTIKDYLSWRYVDTHINNLYNTTFWQLIIKCGLTPQESEKKLCGTFSNEKQEILFSECGINYNNEPEMFKKGSLVTRKGEILHINVIAQIDELFEGY
SIO_010081: YGR024C
subclass of: SO_0000673
so part of: YGR024C
location: complement(531883..532596)
location: region:531883-532596:-1
so has part: feature:531883-532596:-1:exon

NP_011538.3
type: Protein
SIO_000068: ncbiprotein

S000003256
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:531883-532596:-1:exon

YGR025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR025W
so part of: sequence
location: <532639..>532941
location: region:532639-532941:1
so has part: feature:532639-532941:1:exon
subclass of: SO_0000010

852909
type: Gene
SIO_000068: ncbigene

position:532639:1
position: 532639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:532941:1
position: 532941
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:532639-532941:1:exon

YGR025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR025W
product: uncharacterized protein
transcript id: NM_001348839.1
SIO_010081: YGR025W
subclass of: SO_0000673
so part of: YGR025W
location: <532639..>532941
location: region:532639-532941:1
so has part: feature:532639-532941:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:532639-532941:1:exon

YGR025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR025W
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MTGYEPFKFFSIRMSSINSPSVIFKTIKTFNPGKTEEYRAKKAYVQDKGYLRQKRPCPFYYRIPTCTASKYSIGCASSKKLTYTRTKFKFNLVTQRENSL
SIO_010081: YGR025W
subclass of: SO_0000673
so part of: YGR025W
location: 532639..532941
location: region:532639-532941:1
so has part: feature:532639-532941:1:exon

NP_001335780.1
type: Protein
SIO_000068: ncbiprotein

S000003257
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:532639-532941:1:exon

YGR026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR026W
so part of: sequence
location: <532985..>533821
location: region:532985-533821:1
so has part: feature:532985-533821:1:exon
subclass of: SO_0000010

852910
type: Gene
SIO_000068: ncbigene

position:532985:1
position: 532985
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:533821:1
position: 533821
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:532985-533821:1:exon

YGR026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR026W
product: uncharacterized protein
transcript id: NM_001181155.3
SIO_010081: YGR026W
subclass of: SO_0000673
so part of: YGR026W
location: <532985..>533821
location: region:532985-533821:1
so has part: feature:532985-533821:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:532985-533821:1:exon

YGR026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR026W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
codon start: 1
product: uncharacterized protein
translation: MAKTIKVIRKKDPKKKNLSDPLAKQKLVWKIGHVLTLVFGLLFSITYFYHVLIFFKYRSWKWLFLRVNKNYSFIQSKRWYMKLLSWSPQVMYRLSLIGVFMSESVTMQQNWVGLNPTWNDLLSSENFHTLLIACLWFFGGGKSFYKILPYMILSYLHLTKMNYELNANKEEKIPLTPKDRKMLHLLAYSELLVILALTLDTILFKTGTSGFMLVIYVGIYWLRLNFSPYAQVAVLELLVKFEKYVPKKYRDKWQVIKNFIYMKMKEHEKRTEEVARYA
SIO_010081: YGR026W
subclass of: SO_0000673
so part of: YGR026W
location: 532985..533821
location: region:532985-533821:1
so has part: feature:532985-533821:1:exon

NP_011540.3
type: Protein
SIO_000068: ncbiprotein

S000003258
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:532985-533821:1:exon

YGR027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS31A
gene: RPS25A
locus tag: YGR027C
gene synonym: RPS31A
so part of: sequence
location: complement(<534132..>534458)
location: region:534132-534458:-1
so has part: feature:534132-534458:-1:exon
subclass of: SO_0000010

852911
type: Gene
SIO_000068: ncbigene

position:534132:-1
position: 534132
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:534458:-1
position: 534458
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:534132-534458:-1:exon

YGR027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS31A
gene: RPS25A
locus tag: YGR027C
gene synonym: RPS31A
product: ribosomal 40S subunit protein S25A
transcript id: NM_001181156.1
SIO_010081: YGR027C
subclass of: SO_0000673
so part of: YGR027C
location: complement(<534132..>534458)
location: region:534132-534458:-1
so has part: feature:534132-534458:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:534132-534458:-1:exon

YGR027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS31A
gene: RPS25A
locus tag: YGR027C
gene synonym: RPS31A
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S25A
translation: MPPKQQLSKAAKAAAALAGGKKSKKKWSKKSMKDRAQHAVILDQEKYDRILKEVPTYRYVSVSVLVDRLKIGGSLARIALRHLEKEGIIKPISKHSKQAIYTRATASE
SIO_010081: YGR027C
subclass of: SO_0000673
so part of: YGR027C
location: complement(534132..534458)
location: region:534132-534458:-1
so has part: feature:534132-534458:-1:exon

NP_011541.1
type: Protein
SIO_000068: ncbiprotein

S000003259
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:534132-534458:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 535211..535542
location: region:535211-535542:1
so has part: feature:535211-535542:1:region

S000006965
type: SGD
SIO_000068: sgd

position:535211:1
position: 535211
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:535542:1
position: 535542
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535211-535542:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(535607..535759)
location: region:535607-535759:-1
so has part: feature:535607-535759:-1:region

S000006952
type: SGD
SIO_000068: sgd

position:535607:-1
position: 535607
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:535759:-1
position: 535759
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535607-535759:-1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YGRWTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YGRWTy1-1
so part of: sequence
location: 535760..541685
location: region:535760-541685:1
so has part: feature:535760-541685:1:region

S000006982
type: SGD
SIO_000068: sgd

position:535760:1
position: 535760
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:541685:1
position: 541685
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535760-541685:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 535760..536097
location: region:535760-536097:1
so has part: feature:535760-536097:1:region

S000006966
type: SGD
SIO_000068: sgd

position:536097:1
position: 536097
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:535760-536097:1:region

YGR027W-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR027W-B
so part of: sequence
location: <536057..>541325
location: region:536057-541325:1
so has part: feature:536057-541325:1:exon
subclass of: SO_0000010

852913
type: Gene
SIO_000068: ncbigene

position:536057:1
position: 536057
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:541325:1
position: 541325
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:536057-541325:1:exon

YGR027W-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR027W-B
product: gag-pol fusion protein
transcript id: NM_001184432.2
SIO_010081: YGR027W-B
subclass of: SO_0000673
so part of: YGR027W-B
location: <536057..>541325
location: region:536057-541325:1
so has part: feature:536057-541325:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:536057-541325:1:exon

YGR027W-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR027W-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVQYGDFYWVSKRYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSRQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIQQCGMEEVRGWSCVFKNSQVTICLFVDDMVLFSKNLNSNKRIIDKLKMQYDTKIINLGESDEEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELDKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YGR027W-B
subclass of: SO_0000673
so part of: YGR027W-B
location: join(536057..537361,537363..541325)
location: region:536057-541325:1
so has part: feature:536057-537361:1:exon
so has part: feature:537363-541325:1:exon

NP_058158.1
type: Protein
SIO_000068: ncbiprotein

S000007406
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:536057-537361:1:exon

position:537361:1
position: 537361
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:537363-541325:1:exon

position:537363:1
position: 537363
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGR027W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR027W-A
so part of: sequence
location: <536057..>537379
location: region:536057-537379:1
so has part: feature:536057-537379:1:exon
subclass of: SO_0000010

852912
type: Gene
SIO_000068: ncbigene

position:537379:1
position: 537379
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:536057-537379:1:exon

YGR027W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR027W-A
product: gag protein
transcript id: NM_001184431.1
SIO_010081: YGR027W-A
subclass of: SO_0000673
so part of: YGR027W-A
location: <536057..>537379
location: region:536057-537379:1
so has part: feature:536057-537379:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:536057-537379:1:exon

YGR027W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR027W-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YGR027W-A
subclass of: SO_0000673
so part of: YGR027W-A
location: 536057..537379
location: region:536057-537379:1
so has part: feature:536057-537379:1:exon

NP_058159.1
type: Protein
SIO_000068: ncbiprotein

S000007405
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:536057-537379:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 541348..541685
location: region:541348-541685:1
so has part: feature:541348-541685:1:region

S000006967
type: SGD
SIO_000068: sgd

position:541348:1
position: 541348
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541348-541685:1:region

YNCG0022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0022W
so part of: sequence
location: 541850..541921
location: region:541850-541921:1
so has part: feature:541850-541921:1:exon
subclass of: SO_0000663

852914
type: Gene
SIO_000068: ncbigene

position:541850:1
position: 541850
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:541921:1
position: 541921
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541850-541921:1:exon

YNCG0022W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0022W
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; target of K. lactis zymocin
SIO_010081: YNCG0022W
subclass of: SO_0000673
so part of: YNCG0022W
location: 541850..541921
location: region:541850-541921:1
so has part: feature:541850-541921:1:exon

S000006555
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541850-541921:1:exon

YGR028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YTA4
gene: MSP1
locus tag: YGR028W
gene synonym: YTA4
so part of: sequence
location: <542203..>543291
location: region:542203-543291:1
so has part: feature:542203-543291:1:exon
subclass of: SO_0000010

852915
type: Gene
SIO_000068: ncbigene

position:542203:1
position: 542203
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:543291:1
position: 543291
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:542203-543291:1:exon

YGR028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YTA4
gene: MSP1
locus tag: YGR028W
gene synonym: YTA4
product: Msp1p
transcript id: NM_001181157.3
SIO_010081: YGR028W
subclass of: SO_0000673
so part of: YGR028W
location: <542203..>543291
location: region:542203-543291:1
so has part: feature:542203-543291:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:542203-543291:1:exon

YGR028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YTA4
gene: MSP1
locus tag: YGR028W
gene synonym: YTA4
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:8226973|PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:24821790]
experiment: EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:8226973]
note: Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain
codon start: 1
product: Msp1p
translation: MSRKFDLKTITDLSVLVGTGISLYYLVSRLLNDVESGPLSGKSRESKAKQSLQWEKLVKRSPALAEVTLDAYERTILSSIVTPDEINITFQDIGGLDPLISDLHESVIYPLMMPEVYSNSPLLQAPSGVLLYGPPGCGKTMLAKALAKESGANFISIRMSSIMDKWYGESNKIVDAMFSLANKLQPCIIFIDEIDSFLRERSSTDHEVTATLKAEFMTLWDGLLNNGRVMIIGATNRINDIDDAFLRRLPKRFLVSLPGSDQRYKILSVLLKDTKLDEDEFDLQLIADNTKGFSGSDLKELCREAALDAAKEYIKQKRQLIDSGTIDVNDTSSLKIRPLKTKDFTKKLRMDATSTLSSQPLD
SIO_010081: YGR028W
subclass of: SO_0000673
so part of: YGR028W
location: 542203..543291
location: region:542203-543291:1
so has part: feature:542203-543291:1:exon

NP_011542.3
type: Protein
SIO_000068: ncbiprotein

S000003260
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:542203-543291:1:exon

YGR029W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERV1
locus tag: YGR029W
so part of: sequence
location: <543553..>544205
location: region:543553-544205:1
so has part: feature:543553-544205:1:exon
subclass of: SO_0000010

852916
type: Gene
SIO_000068: ncbigene

position:543553:1
position: 543553
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:544205:1
position: 544205
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:543553-544205:1:exon

YGR029W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERV1
locus tag: YGR029W
product: flavin-linked sulfhydryl oxidase
transcript id: NM_001181158.3
SIO_010081: YGR029W
subclass of: SO_0000673
so part of: YGR029W
location: join(<543553..543638,543722..>544205)
location: region:543553-544205:1
so has part: feature:543553-543638:1:exon
so has part: feature:543722-544205:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:543553-543638:1:exon

position:543638:1
position: 543638
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:543722-544205:1:exon

position:543722:1
position: 543722
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGR029W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERV1
locus tag: YGR029W
EC number: 1.8.3.2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:11493598]
experiment: EXISTENCE:direct assay:GO:0006879 cellular iron ion homeostasis [PMID:11493598]
experiment: EXISTENCE:direct assay:GO:0016971 flavin-linked sulfhydryl oxidase activity [PMID:10899311]
experiment: EXISTENCE:mutant phenotype:GO:0016972 thiol oxidase activity [PMID:15989955]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15989955]
experiment: EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15989955|PMID:16181637]
note: Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation
codon start: 1
product: flavin-linked sulfhydryl oxidase
translation: MKAIDKMTDNPPQEGLSGRKIIYDEDGKPCRSCNTLLDFQYVTGKISNGLKNLSSNGKLAGTGALTGEASELMPGSRTYRKVDPPDVEQLGRSSWTLLHSVAASYPAQPTDQQKGEMKQFLNIFSHIYPCNWCAKDFEKYIRENAPQVESREELGRWMCEAHNKVNKKLRKPKFDCNFWEKRWKDGWDE
SIO_010081: YGR029W
subclass of: SO_0000673
so part of: YGR029W
location: join(543553..543638,543722..544205)
location: region:543553-544205:1
so has part: feature:543553-543638:1:exon
so has part: feature:543722-544205:1:exon

NP_011543.4
type: Protein
SIO_000068: ncbiprotein

S000003261
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:543553-543638:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:543722-544205:1:exon

YNCG0023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0023C
so part of: sequence
location: complement(544577..544648)
location: region:544577-544648:-1
so has part: feature:544577-544648:-1:exon
subclass of: SO_0000663

852917
type: Gene
SIO_000068: ncbigene

position:544577:-1
position: 544577
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:544648:-1
position: 544648
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:544577-544648:-1:exon

YNCG0023C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0023C
product: tRNA-Asp
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Aspartate tRNA (tRNA-Asp), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0023C
subclass of: SO_0000673
so part of: YNCG0023C
location: complement(544577..544648)
location: region:544577-544648:-1
so has part: feature:544577-544648:-1:exon

S000006533
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:544577-544648:-1:exon

YNCG0024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR46
locus tag: YNCG0024W
so part of: sequence
location: 545370..545566
location: region:545370-545566:1
so has part: feature:545370-545566:1:exon
subclass of: SO_0000578

9164897
type: Gene
SIO_000068: ncbigene

position:545370:1
position: 545370
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:545566:1
position: 545566
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545370-545566:1:exon

YNCG0024W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR46
locus tag: YNCG0024W
product: SNR46
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:9160748]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9160748]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U2865
transcript id: NR_132182.1
SIO_010081: YNCG0024W
subclass of: SO_0000673
so part of: YNCG0024W
location: 545370..545566
location: region:545370-545566:1
so has part: feature:545370-545566:1:exon

S000006506
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545370-545566:1:exon

YGR030C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POP6
locus tag: YGR030C
so part of: sequence
location: complement(<545681..>546157)
location: region:545681-546157:-1
so has part: feature:545681-546157:-1:exon
subclass of: SO_0000010

852918
type: Gene
SIO_000068: ncbigene

position:545681:-1
position: 545681
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:546157:-1
position: 546157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545681-546157:-1:exon

YGR030C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POP6
locus tag: YGR030C
product: ribonuclease P/MRP protein subunit POP6
transcript id: NM_001181159.1
SIO_010081: YGR030C
subclass of: SO_0000673
so part of: YGR030C
location: complement(<545681..>546157)
location: region:545681-546157:-1
so has part: feature:545681-546157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:545681-546157:-1:exon

YGR030C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POP6
locus tag: YGR030C
EC number: 3.1.26.5
experiment: EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [PMID:14729943]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:26135751]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]
experiment: EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9620854]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854]
experiment: EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]
note: Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: ribonuclease P/MRP protein subunit POP6
translation: MINGVYYNEISRDLDISSSTQCLRFLKETVIPSLANNGNNSTSIQYHGISKNDNIKKSVNKLDKQINMADRSLGLQQVVCIFSYGPHIQKMLSILEIFKKGYIKNNKKIYQWNKLTSFDIKREGRNELQEERLKVPILVTLVSDSEIIDLNLHSFTKQ
SIO_010081: YGR030C
subclass of: SO_0000673
so part of: YGR030C
location: complement(545681..546157)
location: region:545681-546157:-1
so has part: feature:545681-546157:-1:exon

NP_011544.1
type: Protein
SIO_000068: ncbiprotein

S000003262
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545681-546157:-1:exon

YGR031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMO32
locus tag: YGR031W
so part of: sequence
location: <546441..>547469
location: region:546441-547469:1
so has part: feature:546441-547469:1:exon
subclass of: SO_0000010

852919
type: Gene
SIO_000068: ncbigene

position:546441:1
position: 546441
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547469:1
position: 547469
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546441-547469:1:exon

YGR031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IMO32
locus tag: YGR031W
product: Imo32p
transcript id: NM_001181160.1
SIO_010081: YGR031W
subclass of: SO_0000673
so part of: YGR031W
location: <546441..>547469
location: region:546441-547469:1
so has part: feature:546441-547469:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546441-547469:1:exon

YGR031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IMO32
locus tag: YGR031W
experiment: EXISTENCE:direct assay:GO:0004806 triglyceride lipase activity [PMID:28465236]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21525245|PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0044255 cellular lipid metabolic process [PMID:28465236]
experiment: EXISTENCE:mutant phenotype:GO:0004806 triglyceride lipase activity [PMID:28465236]
experiment: EXISTENCE:mutant phenotype:GO:0044255 cellular lipid metabolic process [PMID:28465236]
note: Conserved mitochondrial hypothetical protein; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
codon start: 1
product: Imo32p
translation: MMILGKAGILAQYGTIYVRQNTIRNNLSSCIFKQSLCAFHSLAKVLQQKQVPLDLSYDIIKRDAVKTGDEGKPRPPIIILHGLFGNKLNNRSIGRNLNKKLGRDVYLLDLRNHGSSPHSSVHNYEVMSEDVKHFITKHELNTNGGPIIIGHSMGGKVAMMLVLKNPQLCSMLVCIENAPVSLRPNAEFVEYIKALMEIVNDKGKTIRTLKQADEHLAERIGGNELVRRFLLTALKKVKMDNSSSVSSYTFEERIPLATLKDAIVKGEIAAWPLDPARERWTRPALFIRATQSHYVVDEYLPIIGAFFPRFETRDIDAGHWVNAEKPGECAESIVDFVERHED
SIO_010081: YGR031W
subclass of: SO_0000673
so part of: YGR031W
location: 546441..547469
location: region:546441-547469:1
so has part: feature:546441-547469:1:exon

NP_011545.1
type: Protein
SIO_000068: ncbiprotein

S000003263
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546441-547469:1:exon

YGR031C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NAG1
locus tag: YGR031C-A
so part of: sequence
location: complement(<546809..>547300)
location: region:546809-547300:-1
so has part: feature:546809-547300:-1:exon
subclass of: SO_0000010

8656591
type: Gene
SIO_000068: ncbigene

position:546809:-1
position: 546809
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:547300:-1
position: 547300
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546809-547300:-1:exon

YGR031C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NAG1
locus tag: YGR031C-A
product: Nag1p
transcript id: NM_001184658.1
SIO_010081: YGR031C-A
subclass of: SO_0000673
so part of: YGR031C-A
location: complement(<546809..>547300)
location: region:546809-547300:-1
so has part: feature:546809-547300:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546809-547300:-1:exon

YGR031C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NAG1
locus tag: YGR031C-A
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18310357]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0042546 cell wall biogenesis [PMID:18310357]
note: Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32
codon start: 1
product: Nag1p
translation: MNSAGRVHRSRAGSRGHAAISPLTMASFSVARGIRSSNVYDDTDDELSILTFFSAVRRNRLTSSLPPILSARCSSACFSVRIVLPLSLTISISALMYSTNSALGRKLTGAFSIQTNIEQSCGFFRTSIMATLPPIECPIIIGPPLVFNSCFVIKCFTSSDMTS
SIO_010081: YGR031C-A
subclass of: SO_0000673
so part of: YGR031C-A
location: complement(546809..547300)
location: region:546809-547300:-1
so has part: feature:546809-547300:-1:exon

NP_001027023.1
type: Protein
SIO_000068: ncbiprotein

S000028636
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546809-547300:-1:exon

YGR032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FKS2
gene: GSC2
locus tag: YGR032W
gene synonym: FKS2
so part of: sequence
location: <548264..>553951
location: region:548264-553951:1
so has part: feature:548264-553951:1:exon
subclass of: SO_0000010

852920
type: Gene
SIO_000068: ncbigene

position:548264:1
position: 548264
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:553951:1
position: 553951
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548264-553951:1:exon

YGR032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FKS2
gene: GSC2
locus tag: YGR032W
gene synonym: FKS2
product: 1,3-beta-glucan synthase GSC2
transcript id: NM_001181161.3
SIO_010081: YGR032W
subclass of: SO_0000673
so part of: YGR032W
location: <548264..>553951
location: region:548264-553951:1
so has part: feature:548264-553951:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548264-553951:1:exon

YGR032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FKS2
gene: GSC2
locus tag: YGR032W
gene synonym: FKS2
EC number: 2.4.1.34
experiment: EXISTENCE:direct assay:GO:0000148 1,3-beta-D-glucan synthase complex [PMID:7983071]
experiment: EXISTENCE:direct assay:GO:0003843 1,3-beta-D-glucan synthase activity [PMID:7565718|PMID:7649185]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7565718]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:16116083]
experiment: EXISTENCE:mutant phenotype:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7565718]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:16116083]
note: Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication
codon start: 1
product: 1,3-beta-glucan synthase GSC2
translation: MSYNDPNLNGQYYSNGDGTGDGNYPTYQVTQDQSAYDEYGQPIYTQNQLDDGYYDPNEQYVDGTQFPQGQDPSQDQGPYNNDASYYNQPPNMMNPSSQDGENFSDFSSYGPPSGTYPNDQYTPSQMSYPDQDGSSGASTPYGNGVVNGNGQYYDPNAIEMALPNDPYPAWTADPQSPLPIEQIEDIFIDLTNKFGFQRDSMRNMFDHFMTLLDSRSSRMSPEQALLSLHADYIGGDTANYKKWYFAAQLDMDDEIGFRNMKLGKLSRKARKAKKKNKKAMQEASPEDTEETLNQIEGDNSLEAADFRWKSKMNQLSPFEMVRQIALFLLCWGEANQVRFTPECLCFIYKCASDYLDSAQCQQRPDPLPEGDFLNRVITPLYRFIRSQVYEIVDGRYVKSEKDHNKVIGYDDVNQLFWYPEGIAKIVMEDGTRLIDLPAEERYLKLGEIPWDDVFFKTYKETRSWLHLVTNFNRIWIMHISVYWMYCAYNAPTFYTHNYQQLVDNQPLAAYKWATAALGGTVASLIQVAATLCEWSFVPRKWAGAQHLSRRFWFLCVIMGINLGPVIFVFAYDKDTVYSTAAHVVGAVMFFVAVATLVFFSVMPLGGLFTSYMKKSTRSYVASQTFTASFAPLHGLDRWMSYLVWVTVFAAKYAESYFFLILSLRDPIRILSTTSMRCTGEYWWGNKICKVQPKIVLGLMIATDFILFFLDTYLWYIVVNTVFSVGKSFYLGISILTPWRNIFTRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIIISMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRDSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVLTPHYAERILLSLREIIREDDQFSRVTLLEYLKQLHPVEWDCFVKDTKILAEETAAYENNEDEPEKEDALKSQIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTISGFMNYSRAIKLLYRVENPEIVQMFGGNADGLERELEKMARRKFKFLVSMQRLAKFKPHELENAEFLLRAYPDLQIAYLDEEPPLNEGEEPRIYSALIDGHCEILENGRRRPKFRVQLSGNPILGDGKSDNQNHALIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEELGIEQIHPYTPGLKYEDQSTNHPVAIVGAREYIFSENSGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFINATFMTTRGGVSKAQKGLHLNEDIYAGMNAVLRGGRIKHCEYYQCGKGRDLGFGTILNFTTKIGAGMGEQMLSREYYYLGTQLPIDRFLTFYYAHPGFHLNNLFIQLSLQMFMLTLVNLHALAHESILCVYDRDKPITDVLYPIGCYNFHPAIDWVRRYTLSIFIVFWIAFVPIVVQELIERGLWKATQRFFRHILSLSPMFEVFAGQIYSSALLSDIAVGGARYISTGRGFATSRIPFSILYSRFAGSAIYMGSRSMLMLLFGTVAHWQAPLLWFWASLSALIFAPFIFNPHQFAWEDFFLDYRDYIRWLSRGNNKYHRNSWIGYVRMSRSRVTGFKRKLVGDESEKSAGDASRAHRTNLIMAEIIPCAIYAAGCFIAFTFINAQTGVKTTDEDRVNSTLRIIICTLAPIVIDIGVLFFCMGLSCCSGPLLGMCCKKTGSVMAGIAHGIAVVVHIVFFIVMWVLEGFSFVRMLIGVVTCIQCQRLIFHCMTVLLLTREFKNDHANTAFWTGKWYSTGLGYMAWTQPTRELTAKVIELSEFAADFVLGHVILIFQLPVICIPKIDKFHSIMLFWLKPSRQIRPPIYSLKQARLRKRMVRRYCSLYFLVLIIFAGCIVGPAVASAHVPKDLGSGLTGTFHNLVQPRNVSNNDTGSQMSTYKSHYYTHTPSLKTWSTIK
SIO_010081: YGR032W
subclass of: SO_0000673
so part of: YGR032W
location: 548264..553951
location: region:548264-553951:1
so has part: feature:548264-553951:1:exon

NP_011546.3
type: Protein
SIO_000068: ncbiprotein

S000003264
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548264-553951:1:exon

YGR033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIM21
locus tag: YGR033C
so part of: sequence
location: complement(<554248..>554967)
location: region:554248-554967:-1
so has part: feature:554248-554967:-1:exon
subclass of: SO_0000010

852921
type: Gene
SIO_000068: ncbigene

position:554248:-1
position: 554248
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:554967:-1
position: 554967
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:554248-554967:-1:exon

YGR033C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIM21
locus tag: YGR033C
product: Tim21p
transcript id: NM_001181162.3
SIO_010081: YGR033C
subclass of: SO_0000673
so part of: YGR033C
location: complement(<554248..>554967)
location: region:554248-554967:-1
so has part: feature:554248-554967:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:554248-554967:-1:exon

YGR033C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIM21
locus tag: YGR033C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:15797382|PMID:15878866]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15797382]
note: Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity
codon start: 1
product: Tim21p
translation: MSSSLPRSLLRLGHRKPLFPRYNTFVNSSVITHTSLLRTRLYSNGTGATSGKKDDKTRNKPKPLWPQVKSASTFTFSGILVIGAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLQCDDGITGKERLKAYGELITNDKWTRNRPIVSTKKLDKEGRTHHYMRFHVESKKKIALVHLEAKESKQNYQPDFINMYVDVPGEKRYYLIKPKLHPVSNSKGFLGIRWGPRKD
SIO_010081: YGR033C
subclass of: SO_0000673
so part of: YGR033C
location: complement(554248..554967)
location: region:554248-554967:-1
so has part: feature:554248-554967:-1:exon

NP_011547.3
type: Protein
SIO_000068: ncbiprotein

S000003265
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:554248-554967:-1:exon

YGR034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL26B
locus tag: YGR034W
so part of: sequence
location: <555812..>556672
location: region:555812-556672:1
so has part: feature:555812-556672:1:exon
subclass of: SO_0000010

852922
type: Gene
SIO_000068: ncbigene

position:555812:1
position: 555812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:556672:1
position: 556672
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:555812-556672:1:exon

YGR034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL26B
locus tag: YGR034W
product: ribosomal 60S subunit protein L26B
transcript id: NM_001181163.1
SIO_010081: YGR034W
subclass of: SO_0000673
so part of: YGR034W
location: join(<555812..555830,556308..>556672)
location: region:555812-556672:1
so has part: feature:555812-555830:1:exon
so has part: feature:556308-556672:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:555812-555830:1:exon

position:555830:1
position: 555830
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:556308-556672:1:exon

position:556308:1
position: 556308
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YGR034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL26B
locus tag: YGR034W
experiment: EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]
note: Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L26B
translation: MAKQSLDVSSDRRKARKAYFTAPSSERRVLLSAPLSKELRAQYGIKALPIRRDDEVLVVRGSKKGQEGKISSVYRLKFAVQVDKVTKEKVNGASVPINLHPSKLVITKLHLDKDRKALIQRKGGKLE
SIO_010081: YGR034W
subclass of: SO_0000673
so part of: YGR034W
location: join(555812..555830,556308..556672)
location: region:555812-556672:1
so has part: feature:555812-555830:1:exon
so has part: feature:556308-556672:1:exon

NP_011548.2
type: Protein
SIO_000068: ncbiprotein

S000003266
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:555812-555830:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:556308-556672:1:exon

YGR035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR035C
so part of: sequence
location: complement(<557072..>557422)
location: region:557072-557422:-1
so has part: feature:557072-557422:-1:exon
subclass of: SO_0000010

852923
type: Gene
SIO_000068: ncbigene

position:557072:-1
position: 557072
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:557422:-1
position: 557422
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557072-557422:-1:exon

YGR035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR035C
product: uncharacterized protein
transcript id: NM_001181164.1
SIO_010081: YGR035C
subclass of: SO_0000673
so part of: YGR035C
location: complement(<557072..>557422)
location: region:557072-557422:-1
so has part: feature:557072-557422:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557072-557422:-1:exon

YGR035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR035C
note: hypothetical protein, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MLLTPAKTTRTEDSANSTDDSSKSSNSFMRAIVSSLMVKPITSLTNTVTCRQSSHHNSSPSKITRYDLIKAAAENDLKRSKSQGREKSRRNSNRRNNEEIFVANTASEIQRTKSSI
SIO_010081: YGR035C
subclass of: SO_0000673
so part of: YGR035C
location: complement(557072..557422)
location: region:557072-557422:-1
so has part: feature:557072-557422:-1:exon

NP_011549.1
type: Protein
SIO_000068: ncbiprotein

S000003267
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557072-557422:-1:exon

YGR035W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR035W-A
so part of: sequence
location: <557565..>557786
location: region:557565-557786:1
so has part: feature:557565-557786:1:exon
subclass of: SO_0000010

1466457
type: Gene
SIO_000068: ncbigene

position:557565:1
position: 557565
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:557786:1
position: 557786
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:557565-557786:1:exon

YGR035W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR035W-A
product: uncharacterized protein
transcript id: NM_001184648.1
SIO_010081: YGR035W-A
subclass of: SO_0000673
so part of: YGR035W-A
location: <557565..>557786
location: region:557565-557786:1
so has part: feature:557565-557786:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:557565-557786:1:exon

YGR035W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR035W-A
codon start: 1
product: uncharacterized protein
translation: MLLYLYILYIALKTVSHLFFCNPCFRNLSVGDMLNPRLSLSFFTNHLLCPEAPLIIRGKGSYSAVGNFFSRKK
SIO_010081: YGR035W-A
subclass of: SO_0000673
so part of: YGR035W-A
location: 557565..557786
location: region:557565-557786:1
so has part: feature:557565-557786:1:exon

NP_878077.1
type: Protein
SIO_000068: ncbiprotein

S000028827
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:557565-557786:1:exon

YGR036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CWH8
gene: CAX4
locus tag: YGR036C
gene synonym: CWH8
so part of: sequence
location: complement(<558149..>558868)
location: region:558149-558868:-1
so has part: feature:558149-558868:-1:exon
subclass of: SO_0000010

852924
type: Gene
SIO_000068: ncbigene

position:558149:-1
position: 558149
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558868:-1
position: 558868
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:558149-558868:-1:exon

YGR036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CWH8
gene: CAX4
locus tag: YGR036C
gene synonym: CWH8
product: dolichyldiphosphatase
transcript id: NM_001181165.3
SIO_010081: YGR036C
subclass of: SO_0000673
so part of: YGR036C
location: complement(<558149..>558868)
location: region:558149-558868:-1
so has part: feature:558149-558868:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:558149-558868:-1:exon

YGR036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CWH8
gene: CAX4
locus tag: YGR036C
gene synonym: CWH8
EC number: 3.6.1.43
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11504728]
experiment: EXISTENCE:direct assay:GO:0047874 dolichyldiphosphatase activity [PMID:11504728]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:10024662]
experiment: EXISTENCE:mutant phenotype:GO:0008610 lipid biosynthetic process [PMID:11504728]
note: Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis
codon start: 1
product: dolichyldiphosphatase
translation: MNSTAAAINPNPNVIPFDDTYILYDSHDFLSFLSAYFSLMPILVLAFYLSWFIITRELEACIVAFGQLMNEIFNNVIKNIIKQPRPVSFGASFQNDTIRSGYGMPSAHSQFMGFCFTYNSLKIYTSWKNLNFLEKCIFSGALALLSFCVCFSRVYLHYHNLDQVIVGFSVGALTGSLYFFIVGIIRELGLINWFLKLRIVRLFYMTDSYNLAPLTLKENYEAYWKRINQRSFNDKSKRD
SIO_010081: YGR036C
subclass of: SO_0000673
so part of: YGR036C
location: complement(558149..558868)
location: region:558149-558868:-1
so has part: feature:558149-558868:-1:exon

NP_011550.3
type: Protein
SIO_000068: ncbiprotein

S000003268
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:558149-558868:-1:exon

YGR037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACB1
locus tag: YGR037C
so part of: sequence
location: complement(<559731..>559994)
location: region:559731-559994:-1
so has part: feature:559731-559994:-1:exon
subclass of: SO_0000010

852925
type: Gene
SIO_000068: ncbigene

position:559731:-1
position: 559731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:559994:-1
position: 559994
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559731-559994:-1:exon

YGR037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACB1
locus tag: YGR037C
product: long-chain fatty acid transporter ACB1
transcript id: NM_001181166.3
SIO_010081: YGR037C
subclass of: SO_0000673
so part of: YGR037C
location: complement(<559731..>559994)
location: region:559731-559994:-1
so has part: feature:559731-559994:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559731-559994:-1:exon

YGR037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACB1
locus tag: YGR037C
experiment: EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:20156967]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005576 extracellular region [PMID:20156967]
experiment: EXISTENCE:mutant phenotype:GO:0036042 long-chain fatty acyl-CoA binding [PMID:11294913]
experiment: EXISTENCE:mutant phenotype:GO:0042761 very long-chain fatty acid biosynthetic process [PMID:11294913]
note: Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
codon start: 1
product: long-chain fatty acid transporter ACB1
translation: MVSQLFEEKAKAVNELPTKPSTDELLELYALYKQATVGDNDKEKPGIFNMKDRYKWEAWENLKGKSQEDAEKEYIALVDQLIAKYSS
SIO_010081: YGR037C
subclass of: SO_0000673
so part of: YGR037C
location: complement(559731..559994)
location: region:559731-559994:-1
so has part: feature:559731-559994:-1:exon

NP_011551.3
type: Protein
SIO_000068: ncbiprotein

S000003269
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559731-559994:-1:exon

YGR038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ORM1
locus tag: YGR038W
so part of: sequence
location: <560682..>561350
location: region:560682-561350:1
so has part: feature:560682-561350:1:exon
subclass of: SO_0000010

852926
type: Gene
SIO_000068: ncbigene

position:560682:1
position: 560682
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:561350:1
position: 561350
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:560682-561350:1:exon

YGR038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ORM1
locus tag: YGR038W
product: sphingolipid homeostasis protein ORM1
transcript id: NM_001181167.1
SIO_010081: YGR038W
subclass of: SO_0000673
so part of: YGR038W
location: <560682..>561350
location: region:560682-561350:1
so has part: feature:560682-561350:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:560682-561350:1:exon

YGR038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ORM1
locus tag: YGR038W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20182505|PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0035339 SPOTS complex [PMID:20182505]
experiment: EXISTENCE:genetic interaction:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]
experiment: EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:12093374]
experiment: EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]
experiment: EXISTENCE:physical interaction:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]
note: Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication
codon start: 1
product: sphingolipid homeostasis protein ORM1
translation: MTELDYQGTAEAASTSYSRNQTDLKPFPSAGSASSSIKTTEPVKDHRRRRSSSIISHVEPETFEDENDQQLLPNMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS
SIO_010081: YGR038W
subclass of: SO_0000673
so part of: YGR038W
location: 560682..561350
location: region:560682-561350:1
so has part: feature:560682-561350:1:exon

NP_011552.1
type: Protein
SIO_000068: ncbiprotein

S000003270
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:560682-561350:1:exon

YNCG0025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCG0025C
so part of: sequence
location: complement(561662..561743)
location: region:561662-561743:-1
so has part: feature:561662-561743:-1:exon
subclass of: SO_0000663

852927
type: Gene
SIO_000068: ncbigene

position:561662:-1
position: 561662
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:561743:-1
position: 561743
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561662-561743:-1:exon

YNCG0025C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCG0025C
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCG0025C
subclass of: SO_0000673
so part of: YNCG0025C
location: complement(561662..561743)
location: region:561662-561743:-1
so has part: feature:561662-561743:-1:exon

S000006725
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:561662-561743:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YGRCTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YGRCTy1-2
so part of: sequence
location: complement(561843..567760)
location: region:561843-567760:-1
so has part: feature:561843-567760:-1:region

S000006962
type: SGD
SIO_000068: sgd

position:561843:-1
position: 561843
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:567760:-1
position: 567760
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561843-567760:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(561843..562176)
location: region:561843-562176:-1
so has part: feature:561843-562176:-1:region

S000006953
type: SGD
SIO_000068: sgd

position:562176:-1
position: 562176
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561843-562176:-1:region

YGR038C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR038C-B
so part of: sequence
location: complement(<562199..>567467)
location: region:562199-567467:-1
so has part: feature:562199-567467:-1:exon
subclass of: SO_0000010

852928
type: Gene
SIO_000068: ncbigene

position:562199:-1
position: 562199
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:567467:-1
position: 567467
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:562199-567467:-1:exon

YGR038C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR038C-B
product: gag-pol fusion protein
transcript id: NM_001184434.2
SIO_010081: YGR038C-B
subclass of: SO_0000673
so part of: YGR038C-B
location: complement(<562199..>567467)
location: region:562199-567467:-1
so has part: feature:562199-567467:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:562199-567467:-1:exon

YGR038C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR038C-B
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPGINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPNSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQESNDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMNTWDTDKYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YGR038C-B
subclass of: SO_0000673
so part of: YGR038C-B
location: complement(join(562199..566161,566163..567467))
location: region:562199-567467:-1
so has part: feature:566163-567467:-1:exon
so has part: feature:562199-566161:-1:exon

NP_058160.1
type: Protein
SIO_000068: ncbiprotein

S000007408
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566163-567467:-1:exon

position:566163:-1
position: 566163
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:562199-566161:-1:exon

position:566161:-1
position: 566161
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YGR038C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR038C-A
so part of: sequence
location: complement(<566145..>567467)
location: region:566145-567467:-1
so has part: feature:566145-567467:-1:exon
subclass of: SO_0000010

852929
type: Gene
SIO_000068: ncbigene

position:566145:-1
position: 566145
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566145-567467:-1:exon

YGR038C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR038C-A
product: gag protein
transcript id: NM_001184433.1
SIO_010081: YGR038C-A
subclass of: SO_0000673
so part of: YGR038C-A
location: complement(<566145..>567467)
location: region:566145-567467:-1
so has part: feature:566145-567467:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:566145-567467:-1:exon

YGR038C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR038C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YGR038C-A
subclass of: SO_0000673
so part of: YGR038C-A
location: complement(566145..567467)
location: region:566145-567467:-1
so has part: feature:566145-567467:-1:exon

NP_058161.1
type: Protein
SIO_000068: ncbiprotein

S000007407
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566145-567467:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(567427..567760)
location: region:567427-567760:-1
so has part: feature:567427-567760:-1:region

S000006954
type: SGD
SIO_000068: sgd

position:567427:-1
position: 567427
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:567427-567760:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS721; Autonomously Replicating Sequence
so part of: sequence
location: 568490..568737
location: region:568490-568737:1
so has part: feature:568490-568737:1:region

S000118461
type: SGD
SIO_000068: sgd

position:568490:1
position: 568490
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:568737:1
position: 568737
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568490-568737:1:region

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YGRCTy2-1; Ty2 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats; mutated in S288C
mobile element type: retrotransposon:YGRCTy2-1
so part of: sequence
location: complement(568740..574700)
location: region:568740-574700:-1
so has part: feature:568740-574700:-1:region

S000006964
type: SGD
SIO_000068: sgd

position:568740:-1
position: 568740
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:574700:-1
position: 574700
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568740-574700:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(568740..569072)
location: region:568740-569072:-1
so has part: feature:568740-569072:-1:region

S000006955
type: SGD
SIO_000068: sgd

position:569072:-1
position: 569072
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568740-569072:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty2 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(574369..574700)
location: region:574369-574700:-1
so has part: feature:574369-574700:-1:region

S000006956
type: SGD
SIO_000068: sgd

position:574369:-1
position: 574369
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574369-574700:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS722; Autonomously Replicating Sequence
so part of: sequence
location: 574622..574915
location: region:574622-574915:1
so has part: feature:574622-574915:1:region

S000118462
type: SGD
SIO_000068: sgd

position:574622:1
position: 574622
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:574915:1
position: 574915
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574622-574915:1:region

YGR039W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR039W
so part of: sequence
location: <574888..>575199
location: region:574888-575199:1
so has part: feature:574888-575199:1:exon
subclass of: SO_0000010

852930
type: Gene
SIO_000068: ncbigene

position:574888:1
position: 574888
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:575199:1
position: 575199
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:574888-575199:1:exon

YGR039W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR039W
product: uncharacterized protein
transcript id: NM_001348840.1
SIO_010081: YGR039W
subclass of: SO_0000673
so part of: YGR039W
location: <574888..>575199
location: region:574888-575199:1
so has part: feature:574888-575199:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:574888-575199:1:exon

YGR039W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR039W
note: hypothetical protein; conserved among S. cerevisiae strains; YGR039W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MLFFTGLVILSYLLGGKKDWLLIMYEASDYLEFLNRLSSMLFKFELFEHLSSTFLIFSHSKRAVKLLEIYRSRHISIYNVFLLRHPKYFQSVDIALYLTRSQT
SIO_010081: YGR039W
subclass of: SO_0000673
so part of: YGR039W
location: 574888..575199
location: region:574888-575199:1
so has part: feature:574888-575199:1:exon

NP_001335781.1
type: Protein
SIO_000068: ncbiprotein

S000003271
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:574888-575199:1:exon

YGR040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: KSS1
locus tag: YGR040W
so part of: sequence
location: <575398..>576504
location: region:575398-576504:1
so has part: feature:575398-576504:1:exon
subclass of: SO_0000010

852931
type: Gene
SIO_000068: ncbigene

position:575398:1
position: 575398
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:576504:1
position: 576504
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575398-576504:1:exon

YGR040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: KSS1
locus tag: YGR040W
product: mitogen-activated serine/threonine-protein kinase KSS1
transcript id: NM_001181169.3
SIO_010081: YGR040W
subclass of: SO_0000673
so part of: YGR040W
location: <575398..>576504
location: region:575398-576504:1
so has part: feature:575398-576504:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:575398-576504:1:exon

YGR040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: KSS1
locus tag: YGR040W
EC number: 2.7.11.24
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:8668180|PMID:8918885]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:7579701]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27400980]
experiment: EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:27400980]
experiment: EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:11583629]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:9393860]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]
experiment: EXISTENCE:mutant phenotype:GO:0043433 negative regulation of DNA-binding transcription factor activity [PMID:9744865]
note: Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
codon start: 1
product: mitogen-activated serine/threonine-protein kinase KSS1
translation: MARTITFDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSDEPEYPPLNLDDEFWKLDNKIMRPEEEEEVPIEMLKDMLYDELMKTME
SIO_010081: YGR040W
subclass of: SO_0000673
so part of: YGR040W
location: 575398..576504
location: region:575398-576504:1
so has part: feature:575398-576504:1:exon

NP_011554.3
type: Protein
SIO_000068: ncbiprotein

S000003272
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:575398-576504:1:exon

YGR040W
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
gene: KSS1
locus tag: YGR040W
note: ARS723; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
SIO_010081: YGR040W
subclass of: SO_0000673
so part of: YGR040W
location: 575484..576346
location: region:575484-576346:1
so has part: feature:575484-576346:1:exon

S000130166
type: SGD
SIO_000068: sgd

position:575484:1
position: 575484
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:576346:1
position: 576346
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575484-576346:1:exon

YGR041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUD9
locus tag: YGR041W
so part of: sequence
location: <577487..>579130
location: region:577487-579130:1
so has part: feature:577487-579130:1:exon
subclass of: SO_0000010

852932
type: Gene
SIO_000068: ncbigene

position:577487:1
position: 577487
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:579130:1
position: 579130
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:577487-579130:1:exon

YGR041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUD9
locus tag: YGR041W
product: Bud9p
transcript id: NM_001181170.3
SIO_010081: YGR041W
subclass of: SO_0000673
so part of: YGR041W
location: <577487..>579130
location: region:577487-579130:1
so has part: feature:577487-579130:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:577487-579130:1:exon

YGR041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUD9
locus tag: YGR041W
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11514631|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:8657162]
experiment: EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:17581861]
note: Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication
codon start: 1
product: Bud9p
translation: MTKITRDVSITTENSKSTSGSATASSASLPENDHPIFHQPRARIRSGSLFIEGSDSFPSSEVKSYNVYIDDSKYSEILKGDTNSSSTDGKQVFEDARDDNFHQESHRDLEDSILDLVRRDPEVAAFPLPPPNSNERNRNSSNGSSAETNLNGHSSSGTISTSVLLNMGSAEKHAGTTRGDHMESSSMKSFEKLGTRPSSLFYPPPEGTAPYQGPRATVSGNKSTRQTQGTYSFPSMRYGVDLVSPVEGAVDVAKSRVPNSTLNGTFPDKAFIPHEFQIPKKAWNRIPANKSTSLKTPRNHSLLIDILKPFEAADLANDQRSSSAVLKNTVHSNGQYNPTNETSGTRMQDQRQKNTNEIDLEKIPNPQVPLGIAMDTMRSPNQLHEKEYESNIEAGLASGVGKGDNSIKQHQYKKIPQEIDRDQQLSFQMETMPIQRIDSSSIRSFDSRIYGFSEIYSIPRVITTLCICLFVPPLFFFFSINGNNGVSNYRLMRMIMNYEHRIGLLKGFEWDIDVQWFRTLCFVLGCIEMLAIFASIGIGFGVGIIRE
SIO_010081: YGR041W
subclass of: SO_0000673
so part of: YGR041W
location: 577487..579130
location: region:577487-579130:1
so has part: feature:577487-579130:1:exon

NP_011555.3
type: Protein
SIO_000068: ncbiprotein

S000003273
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:577487-579130:1:exon

YGR042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTE1
locus tag: YGR042W
so part of: sequence
location: <579476..>580291
location: region:579476-580291:1
so has part: feature:579476-580291:1:exon
subclass of: SO_0000010

852933
type: Gene
SIO_000068: ncbigene

position:579476:1
position: 579476
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:580291:1
position: 580291
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:579476-580291:1:exon

YGR042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTE1
locus tag: YGR042W
product: Mte1p
transcript id: NM_001181171.1
SIO_010081: YGR042W
subclass of: SO_0000673
so part of: YGR042W
location: <579476..>580291
location: region:579476-580291:1
so has part: feature:579476-580291:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:579476-580291:1:exon

YGR042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTE1
locus tag: YGR042W
experiment: EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:26966248]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:26966248]
experiment: EXISTENCE:direct assay:GO:0051096 positive regulation of helicase activity [PMID:26966248]
experiment: EXISTENCE:mutant phenotype:GO:0032205 negative regulation of telomere maintenance [PMID:26966248]
note: hypothetical protein; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
codon start: 1
product: Mte1p
translation: MLSHIVEYECQYTDQLYKKRKIWHDGRLKYFQLNNRFMLYTEKDNVLLASEFKINSKELKAILNPEGFDIEEHRIFSQFLVIISNIIEEYDRDIQVAATHVRAYPSNLSVQKQRPLISDNAPSLNHISTAREVHSNIKVTTPNRKQTEDNATKGGFNISKLTLKVNKPFKKPKRILSTNVVNESNRPSIRSQKIQEVTPQLHETNTSTKVQTAGKVALNNDNIAQGNYATITEEAKVRDGSDRKKDMANLSKSGKRRVGGIRRIVHEPLGI
SIO_010081: YGR042W
subclass of: SO_0000673
so part of: YGR042W
location: 579476..580291
location: region:579476-580291:1
so has part: feature:579476-580291:1:exon

NP_011556.1
type: Protein
SIO_000068: ncbiprotein

S000003274
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:579476-580291:1:exon

YGR043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NQM1
locus tag: YGR043C
so part of: sequence
location: complement(<580435..>581436)
location: region:580435-581436:-1
so has part: feature:580435-581436:-1:exon
subclass of: SO_0000010

852934
type: Gene
SIO_000068: ncbigene

position:580435:-1
position: 580435
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:581436:-1
position: 581436
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:580435-581436:-1:exon

YGR043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NQM1
locus tag: YGR043C
product: sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase NQM1
transcript id: NM_001181172.1
SIO_010081: YGR043C
subclass of: SO_0000673
so part of: YGR043C
location: complement(<580435..>581436)
location: region:580435-581436:-1
so has part: feature:580435-581436:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:580435-581436:-1:exon

YGR043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NQM1
locus tag: YGR043C
EC number: 2.2.1.2
experiment: EXISTENCE:direct assay:GO:0004801 transaldolase activity [PMID:18831051]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:25887987]
note: Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication
codon start: 1
product: sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase NQM1
translation: MSEPSEKKQKVATSSLEQLKKAGTHVVADSGDFEAISKYEPQDSTTNPSLILAASKLEKYARFIDAAVEYGRKHGKTDHEKIENAMDKILVEFGTQILKVVPGRVSTEVDARLSFDKKATVKKALHIIKLYKDAGVPKERVLIKIASTWEGIQAARELEVKHGIHCNMTLLFSFTQAVACAEANVTLISPFVGRIMDFYKALSGKDYTAETDPGVLSVKKIYSYYKRHGYATEVMAASFRNLDELKALAGIDNMTLPLNLLEQLYESTDPIENKLNSESAKEEGVEKVSFINDEPHFRYVLNEDQMATEKLSDGIRKFSADIEALYKLVEEKM
SIO_010081: YGR043C
subclass of: SO_0000673
so part of: YGR043C
location: complement(580435..581436)
location: region:580435-581436:-1
so has part: feature:580435-581436:-1:exon

NP_011557.1
type: Protein
SIO_000068: ncbiprotein

S000003275
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:580435-581436:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS724; Putative replication origin; identified in multiple array studies, not yet confirmed by plasmid-based assay
so part of: sequence
location: 581436..582213
location: region:581436-582213:1
so has part: feature:581436-582213:1:region

S000130167
type: SGD
SIO_000068: sgd

position:581436:1
position: 581436
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:582213:1
position: 582213
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:581436-582213:1:region

YGR044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CSP1
gene: RME1
locus tag: YGR044C
gene synonym: CSP1
so part of: sequence
location: complement(<582990..>583892)
location: region:582990-583892:-1
so has part: feature:582990-583892:-1:exon
subclass of: SO_0000010

852935
type: Gene
SIO_000068: ncbigene

position:582990:-1
position: 582990
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:583892:-1
position: 583892
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:582990-583892:-1:exon

YGR044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CSP1
gene: RME1
locus tag: YGR044C
gene synonym: CSP1
product: Rme1p
transcript id: NM_001181173.1
SIO_010081: YGR044C
subclass of: SO_0000673
so part of: YGR044C
location: complement(<582990..>583892)
location: region:582990-583892:-1
so has part: feature:582990-583892:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:582990-583892:-1:exon

YGR044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CSP1
gene: RME1
locus tag: YGR044C
gene synonym: CSP1
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9580682]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9580682]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11713667|PMID:9580682|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12006664|PMID:14668363]
experiment: EXISTENCE:direct assay:GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:11713667]
experiment: EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8339935]
experiment: EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:3513021]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12006664]
experiment: EXISTENCE:mutant phenotype:GO:0051038 negative regulation of transcription involved in meiotic cell cycle [PMID:8339935]
note: Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
codon start: 1
product: Rme1p
translation: MSPCYGQNSAIAKGSWNREVLQEVQPIYHWHDFGQNMKEYSASPLEGDSSLPSSLPSSTEDCLLLSLENTITVIAGNQRQAYDSTSSTEEGTAPQLRPDEIADSTHCITSLVDPEFRDLINYGRQKGANPVFIESNTTEQSHSQCILGYPQKSHVAQLYHDPKVLSTISEGQTKRGSYHCSHCSEKFATLVEFAAHLDEFNLERPCKCPIEQCPWKILGFQQATGLRRHCASQHIGELDIEMEKSLNLKVEKYPGLNCPFPICQKTFRRKDAYKRHVAMVHNNADSRFNKRLKKILNNTK
SIO_010081: YGR044C
subclass of: SO_0000673
so part of: YGR044C
location: complement(582990..583892)
location: region:582990-583892:-1
so has part: feature:582990-583892:-1:exon

NP_011558.1
type: Protein
SIO_000068: ncbiprotein

S000003276
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:582990-583892:-1:exon

YGR045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR045C
so part of: sequence
location: complement(<583934..>584296)
location: region:583934-584296:-1
so has part: feature:583934-584296:-1:exon
subclass of: SO_0000010

852936
type: Gene
SIO_000068: ncbigene

position:583934:-1
position: 583934
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:584296:-1
position: 584296
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:583934-584296:-1:exon

YGR045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR045C
product: uncharacterized protein
transcript id: NM_001348841.1
SIO_010081: YGR045C
subclass of: SO_0000673
so part of: YGR045C
location: complement(<583934..>584296)
location: region:583934-584296:-1
so has part: feature:583934-584296:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:583934-584296:-1:exon

YGR045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR045C
note: hypothetical protein; conserved across S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MSQITSKGRRILDKKIRTFPVGFTSRKVAGHVLNISPYFLLAFSYAENKGQSAFEEIKGSNVIDMSCVICFNFSCHLFVVIFISRSTETIPTTKLLLSKYIFYCVNALELTLFLSYKSYS
SIO_010081: YGR045C
subclass of: SO_0000673
so part of: YGR045C
location: complement(583934..584296)
location: region:583934-584296:-1
so has part: feature:583934-584296:-1:exon

NP_001335782.1
type: Protein
SIO_000068: ncbiprotein

S000003277
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:583934-584296:-1:exon

YGR046W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMP37
gene: TAM41
locus tag: YGR046W
gene synonym: MMP37
so part of: sequence
location: <584895..>586052
location: region:584895-586052:1
so has part: feature:584895-586052:1:exon
subclass of: SO_0000010

852937
type: Gene
SIO_000068: ncbigene

position:584895:1
position: 584895
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:586052:1
position: 586052
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:584895-586052:1:exon

YGR046W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMP37
gene: TAM41
locus tag: YGR046W
gene synonym: MMP37
product: putative phosphatidate cytidylyltransferase
transcript id: NM_001181175.3
SIO_010081: YGR046W
subclass of: SO_0000673
so part of: YGR046W
location: <584895..>586052
location: region:584895-586052:1
so has part: feature:584895-586052:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:584895-586052:1:exon

YGR046W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMP37
gene: TAM41
locus tag: YGR046W
gene synonym: MMP37
EC number: 2.7.7.41
experiment: EXISTENCE:direct assay:GO:0004605 phosphatidate cytidylyltransferase activity [PMID:23623749]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14690591]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:16790493|PMID:16943180]
experiment: EXISTENCE:genetic interaction:GO:0032049 cardiolipin biosynthetic process [PMID:20485265]
experiment: EXISTENCE:mutant phenotype:GO:0004605 phosphatidate cytidylyltransferase activity [PMID:23623749]
experiment: EXISTENCE:mutant phenotype:GO:0032049 cardiolipin biosynthetic process [PMID:19114592]
note: Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
codon start: 1
product: putative phosphatidate cytidylyltransferase
translation: MLRVSENGLRFLLKCHSTNVSMFNRLLSTQIKEGRSSIDDAGIIPDGTINERPNHYIEGITKGSDLDLLEKGIRKTDEMTSNFTNYMYKFHRLPPNYGSNQLITIDKELQKELDGVMSSFKAPCRFVFGYGSGVFEQAGYSKSHSKPQIDIILGVTYPSHFHSINMRQNPQHYSSLKYFGSEFVSKFQQIGAGVYFNPFANINGHDVKYGVVSMETLLKDIATWNTFYLAGRLQKPVKILKNDLRVQYWNQLNLKAAATLAKHYTLEKNNNKFDEFQFYKEITALSYAGDIRYKLGGENPDKVNNIVTKNFERFQEYYKPIYKEVVLNDSFYLPKGFTLKNTQRLLLSRISKSSALQTIKGVFTAGITKSIKYAWAKKLKSMRRS
SIO_010081: YGR046W
subclass of: SO_0000673
so part of: YGR046W
location: 584895..586052
location: region:584895-586052:1
so has part: feature:584895-586052:1:exon

NP_011560.3
type: Protein
SIO_000068: ncbiprotein

S000003278
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:584895-586052:1:exon

YGR047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PCF1
gene: TFC4
locus tag: YGR047C
gene synonym: PCF1
so part of: sequence
location: complement(<586392..>589469)
location: region:586392-589469:-1
so has part: feature:586392-589469:-1:exon
subclass of: SO_0000010

852938
type: Gene
SIO_000068: ncbigene

position:586392:-1
position: 586392
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:589469:-1
position: 589469
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:586392-589469:-1:exon

YGR047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PCF1
gene: TFC4
locus tag: YGR047C
gene synonym: PCF1
product: transcription factor TFIIIC subunit TFC4
transcript id: NM_001181176.3
SIO_010081: YGR047C
subclass of: SO_0000673
so part of: YGR047C
location: complement(<586392..>589469)
location: region:586392-589469:-1
so has part: feature:586392-589469:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:586392-589469:-1:exon

YGR047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PCF1
gene: TFC4
locus tag: YGR047C
gene synonym: PCF1
experiment: EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:1474578|PMID:2002052|PMID:2180956|PMID:8387209]
experiment: EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]
experiment: EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:8464480|PMID:2183033]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]
experiment: EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]
experiment: EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:8264649]
note: Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
codon start: 1
product: transcription factor TFIIIC subunit TFC4
translation: MAAGKLKKEQQNQSAERESADTGKVNDEDEEHLYGNIDDYKHLIQDEEYDDEDVPHDLQLSEDEYNSERDSSLLAEFSDYGEISEDDEEDFMNAIREASNFKVKKKKKNDKGKSYGRQRKERVLDPEVAQLLSQANEAFVRNDLQVAERLFNEVIKKDARNFAAYETLGDIYQLQGRLNDCCNSWFLAAHLNASDWEFWKIVAILSADLDHVRQAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYDANILRELAILYVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAEGEDADEKEPLEQDEDRQMFPDINWKKIDAKYKCIPFDWSSLNILAELFLKLAVSEVDGIKTIKKCARWIQRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSYNIPIDIRVRLGLLRLNTDNLVEALNHFQCLYDETFSDVADLYFEAATALTRAEKYKEAIDFFTPLLSLEEWRTTDVFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDVVEMRKHQVDETLHRISNEKSSNDTSDISSKPLLEDSKFRTFRKKKRTPYDAERERIERERRITAKVVDKYEKMKKFELNSGLNEAKQASIWINTVSELVDIFSSVKNFFMKSRSRKFVGILRRTKKFNTELDFQIERLSKLAEGDSVFEGPLMEERVTLTSATELRGLSYEQWFELFMELSLVIAKYQSVEDGLSVVETAQEVNVFFQDPERVKMMKFVKLAIVLQMDDEEELAENLRGLLNQFQFNRKVLQVFMYSLCRGPSSLNILSSTIQQKFFLRQLKAFDSCRYNTEVNGQASITNKEVYNPNKKSSPYLYYIYAVLLYSSRGFLSALQYLTRLEEDIPDDPMVNLLMGLSHIHRAMQRLTAQRHFQIFHGLRYLYRYHKIRKSLYTDLEKQEADYNLGRAFHLIGLVSIAIEYYNRVLENYDDGKLKKHAAYNSIIIYQQSGNVELADHLMEKYLSI
SIO_010081: YGR047C
subclass of: SO_0000673
so part of: YGR047C
location: complement(586392..589469)
location: region:586392-589469:-1
so has part: feature:586392-589469:-1:exon

NP_011561.3
type: Protein
SIO_000068: ncbiprotein

S000003279
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:586392-589469:-1:exon

YGR048W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UFD1
locus tag: YGR048W
so part of: sequence
location: <589826..>590911
location: region:589826-590911:1
so has part: feature:589826-590911:1:exon
subclass of: SO_0000010

852939
type: Gene
SIO_000068: ncbigene

position:589826:1
position: 589826
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:590911:1
position: 590911
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:589826-590911:1:exon

YGR048W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UFD1
locus tag: YGR048W
product: polyubiquitin-binding protein UFD1
transcript id: NM_001181177.1
SIO_010081: YGR048W
subclass of: SO_0000673
so part of: YGR048W
location: <589826..>590911
location: region:589826-590911:1
so has part: feature:589826-590911:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:589826-590911:1:exon

YGR048W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UFD1
locus tag: YGR048W
experiment: EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11733065|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006274 DNA replication termination [PMID:31509741]
experiment: EXISTENCE:direct assay:GO:0030894 replisome [PMID:31509741]
experiment: EXISTENCE:direct assay:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:16004872]
experiment: EXISTENCE:direct assay:GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex [PMID:11598205|PMID:11733065]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16004872]
experiment: EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:11739805]
experiment: EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:11740563|PMID:11813000]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:20206597]
experiment: EXISTENCE:mutant phenotype:GO:0051974 negative regulation of telomerase activity [PMID:26365526]
experiment: EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]
experiment: EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:18812321]
experiment: EXISTENCE:mutant phenotype:GO:0071712 ER-associated misfolded protein catabolic process [PMID:11740563|PMID:11813000]
experiment: EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]
experiment: EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:11598205|PMID:11733065]
experiment: EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411]
note: Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)
codon start: 1
product: polyubiquitin-binding protein UFD1
translation: MFSGFSSFGGGNGFVNMPQTFEEFFRCYPIAMMNDRIRKDDANFGGKIFLPPSALSKLSMLNIRYPMLFKLTANETGRVTHGGVLEFIAEEGRVYLPQWMMETLGIQPGSLLQISSTDVPLGQFVKLEPQSVDFLDISDPKAVLENVLRNFSTLTVDDVIEISYNGKTFKIKILEVKPESSSKSICVIETDLVTDFAPPVGYVEPDYKALKAQQDKEKKNSFGKGQVLDPSVLGQGSMSTRIDYAGIANSSRNKLSKFVGQGQNISGKAPKAEPKQDIKDMKITFDGEPAKLDLPEGQLFFGFPMVLPKEDEESAAGSKSSEQNFQGQGISLRKSNKRKTKSDHDSSKSKAPKSPEVIEID
SIO_010081: YGR048W
subclass of: SO_0000673
so part of: YGR048W
location: 589826..590911
location: region:589826-590911:1
so has part: feature:589826-590911:1:exon

NP_011562.1
type: Protein
SIO_000068: ncbiprotein

S000003280
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:589826-590911:1:exon

YGR049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCM4
locus tag: YGR049W
so part of: sequence
location: <591314..>591877
location: region:591314-591877:1
so has part: feature:591314-591877:1:exon
subclass of: SO_0000010

852940
type: Gene
SIO_000068: ncbigene

position:591314:1
position: 591314
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:591877:1
position: 591877
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:591314-591877:1:exon

YGR049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCM4
locus tag: YGR049W
product: Scm4p
transcript id: NM_001181178.1
SIO_010081: YGR049W
subclass of: SO_0000673
so part of: YGR049W
location: <591314..>591877
location: region:591314-591877:1
so has part: feature:591314-591877:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:591314-591877:1:exon

YGR049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCM4
locus tag: YGR049W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
note: Mitochondrial outer membrane hypothetical protein; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication
codon start: 1
product: Scm4p
translation: MQVSPAIVKGIAVSSLGLYAGILTSSTVISITTPINVLTQHLKNVLCTLGCWSTVLGGLATGAFGLSYYLAAPGERPNYLLCGLGVAPLSAAYLYLVSLFNHKLAPKCTRDQNDLEKQKDEKLPQHHPEVKDGEAACPFSKMNNAKTLKPESERSVKCHSYMSLHMSIVTGITIFTFGKCILDGFKA
SIO_010081: YGR049W
subclass of: SO_0000673
so part of: YGR049W
location: 591314..591877
location: region:591314-591877:1
so has part: feature:591314-591877:1:exon

NP_011563.1
type: Protein
SIO_000068: ncbiprotein

S000003281
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:591314-591877:1:exon

YGR050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR050C
so part of: sequence
location: complement(<592086..>592442)
location: region:592086-592442:-1
so has part: feature:592086-592442:-1:exon
subclass of: SO_0000010

852941
type: Gene
SIO_000068: ncbigene

position:592086:-1
position: 592086
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:592442:-1
position: 592442
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:592086-592442:-1:exon

YGR050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR050C
product: uncharacterized protein
transcript id: NM_001270748.1
SIO_010081: YGR050C
subclass of: SO_0000673
so part of: YGR050C
location: complement(<592086..>592442)
location: region:592086-592442:-1
so has part: feature:592086-592442:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:592086-592442:-1:exon

YGR050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR050C
note: hypothetical protein; mRNA identified as translated by ribosome profiling data
codon start: 1
product: uncharacterized protein
translation: MKTNLISSFAFRPHVRFGFLDFGYSLKSILDVTSQYHFIPIKLAYGLCDPLLIVYPDPSFSLAQAAGEKKKVVFPTYEDVPKLLLTFKQIMNTYRKGSLGQRQRQRVYGRNGNESHST
SIO_010081: YGR050C
subclass of: SO_0000673
so part of: YGR050C
location: complement(592086..592442)
location: region:592086-592442:-1
so has part: feature:592086-592442:-1:exon

NP_001257677.1
type: Protein
SIO_000068: ncbiprotein

S000003282
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:592086-592442:-1:exon

YGR052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP48
locus tag: YGR052W
so part of: sequence
location: <593596..>594705
location: region:593596-594705:1
so has part: feature:593596-594705:1:exon
subclass of: SO_0000010

852943
type: Gene
SIO_000068: ncbigene

position:593596:1
position: 593596
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:594705:1
position: 594705
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:593596-594705:1:exon

YGR052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP48
locus tag: YGR052W
product: protein kinase FMP48
transcript id: NM_001181181.1
SIO_010081: YGR052W
subclass of: SO_0000673
so part of: YGR052W
location: <593596..>594705
location: region:593596-594705:1
so has part: feature:593596-594705:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:593596-594705:1:exon

YGR052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP48
locus tag: YGR052W
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
codon start: 1
product: protein kinase FMP48
translation: MYTKLRSIQSGTFSTVYKAWSTTHNRYVALKITPKYKTSEANMKNEYDVMKILSSCNPHPNICSMLDFYTDDSYYIMVLEYCECGDLYDFLDIAKSQGSPSSPSLIQIDMQKIIKQLCSAISFAHSLGIAHRDIKPENILLTINGDIKLADWGHAIQSPKSNDFQIGTDNYRAPETFSGRVSNSCFKKNFDRSSAPLYNTYQADYWSLGATIFYLMFGDCLFRVSKSKKVQHLKNFDEFEKDPFAFIYRKYVVPRLSCGYNDEEDLHVSLQHTRQYIWQDLPDIYDVFHLCKIMVDTLLKVSNAKERSMENFINEVDSAWNKDSSMDSCFSYQNKIDLFWEQWSVNTETVPAKFQLKNFEKPCLIQDGK
SIO_010081: YGR052W
subclass of: SO_0000673
so part of: YGR052W
location: 593596..594705
location: region:593596-594705:1
so has part: feature:593596-594705:1:exon

NP_011566.1
type: Protein
SIO_000068: ncbiprotein

S000003284
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:593596-594705:1:exon

YGR053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCO32
locus tag: YGR053C
so part of: sequence
location: complement(<594986..>595837)
location: region:594986-595837:-1
so has part: feature:594986-595837:-1:exon
subclass of: SO_0000010

852944
type: Gene
SIO_000068: ncbigene

position:594986:-1
position: 594986
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:595837:-1
position: 595837
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:594986-595837:-1:exon

YGR053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCO32
locus tag: YGR053C
product: Mco32p
transcript id: NM_001181182.3
SIO_010081: YGR053C
subclass of: SO_0000673
so part of: YGR053C
location: complement(<594986..>595837)
location: region:594986-595837:-1
so has part: feature:594986-595837:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:594986-595837:-1:exon

YGR053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCO32
locus tag: YGR053C
codon start: 1
product: Mco32p
translation: MLLKCVCRAGIISIKGIFPRWYSNSQKVANLGQITDYLVVKGVPNLLQKMFKESVLADNVVFRLFPTSHPYIPVLHGKSKYMASLNAMRMIVRKFILGDECRLHISSVKTLTSTSHDEEVKSALQSYNTITCNDKLVIKWQSCIPEDHCKITKLEINDRLKEEKRGNGAGGSFSMRSVPVIDYILHPTANNLNQSVISEYLENAAERSMENKVNETQNSKEDEKKKNDGDGKRSKKKRLSRLIKGTFIFEFNEENSKILVHTIEDVELIHYEKKIATRGAFAC
SIO_010081: YGR053C
subclass of: SO_0000673
so part of: YGR053C
location: complement(594986..595837)
location: region:594986-595837:-1
so has part: feature:594986-595837:-1:exon

NP_011567.3
type: Protein
SIO_000068: ncbiprotein

S000003285
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:594986-595837:-1:exon

YGR054W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR054W
so part of: sequence
location: <596693..>598621
location: region:596693-598621:1
so has part: feature:596693-598621:1:exon
subclass of: SO_0000010

852945
type: Gene
SIO_000068: ncbigene

position:596693:1
position: 596693
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:598621:1
position: 598621
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:596693-598621:1:exon

YGR054W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR054W
product: uncharacterized protein
transcript id: NM_001181183.4
SIO_010081: YGR054W
subclass of: SO_0000673
so part of: YGR054W
location: <596693..>598621
location: region:596693-598621:1
so has part: feature:596693-598621:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:596693-598621:1:exon

YGR054W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR054W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12133843]
experiment: EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:12133843]
experiment: EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:12133843]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:12133843]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:12133843]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:12133843]
note: Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
codon start: 1
product: uncharacterized protein
translation: MSSQFFLKTSQDIELFQSYPTFEQSNTNSKDFPVISSVLSPCGRFLALSTKENVKVFTGPCLDNVLLTMKLSDVYDLHFSPAGNYLSTWERASIQDPNHKNVKVWYLNKPFKKDCVSEDIVPAYEYQAKSQSGWFLQFSKLDNYGLRLFKHDLKIVKLSSANADNFDFQSPFAVLSDDETSQHFTTYLISPAEHPTICTFTPEKGGKPAQLIIWALSEGKITKKIASKTFFKADSCQLKWNPLGNAILCLAITDFDSSNKSYYGENTLYLLSFQGVNGTLGGNSVRVSLTTGPVHDFTWSPTSRQFGVIAGYMPATISFFDLRGNVVHSLPQQAKNTMLFSPSGHYILIAGFGNLQGSVEILDRLDKFKCVSKFDATNTSVCKWSPGGEFIMTATTSPRLRVDNGVKIWHVSGSLVFVKEFKELLKVDWRSPCNYKTLENKDEAFFENHIINNWEPLPDSTTSSLDPKISNKSELQIHSSVQEYISQHPSREASSNGNGSKAKAGGAYKPPHARRTGGGRIVPGVPPGAAKKTIPGLVPGMSANKDANTKNRRRRANKKSSETSPDSTPAPSAPASTNAPTNNKETSPEEKKIRSLLKKLRAIETLKERQAVGDKLEDTQVLKIQTEEKVLKDLEKLGWKDE
SIO_010081: YGR054W
subclass of: SO_0000673
so part of: YGR054W
location: 596693..598621
location: region:596693-598621:1
so has part: feature:596693-598621:1:exon

NP_011568.3
type: Protein
SIO_000068: ncbiprotein

S000003286
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:596693-598621:1:exon

YGR055W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MUP1
locus tag: YGR055W
so part of: sequence
location: <599417..>601141
location: region:599417-601141:1
so has part: feature:599417-601141:1:exon
subclass of: SO_0000010

852946
type: Gene
SIO_000068: ncbigene

position:599417:1
position: 599417
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:601141:1
position: 601141
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:599417-601141:1:exon

YGR055W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MUP1
locus tag: YGR055W
product: Mup1p
transcript id: NM_001181184.1
SIO_010081: YGR055W
subclass of: SO_0000673
so part of: YGR055W
location: <599417..>601141
location: region:599417-601141:1
so has part: feature:599417-601141:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:599417-601141:1:exon

YGR055W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MUP1
locus tag: YGR055W
experiment: EXISTENCE:direct assay:GO:0000102 L-methionine secondary active transmembrane transporter activity [PMID:8893857]
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25942624]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:1903692 methionine import across plasma membrane [PMID:8893857]
experiment: EXISTENCE:mutant phenotype:GO:0000101 sulfur amino acid transport [PMID:8893857]
experiment: EXISTENCE:mutant phenotype:GO:1903692 methionine import across plasma membrane [PMID:8893857]
note: High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent
codon start: 1
product: Mup1p
translation: MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL
SIO_010081: YGR055W
subclass of: SO_0000673
so part of: YGR055W
location: 599417..601141
location: region:599417-601141:1
so has part: feature:599417-601141:1:exon

NP_011569.1
type: Protein
SIO_000068: ncbiprotein

S000003287
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:599417-601141:1:exon

YGR056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RSC1
locus tag: YGR056W
so part of: sequence
location: <601661..>604447
location: region:601661-604447:1
so has part: feature:601661-604447:1:exon
subclass of: SO_0000010

852947
type: Gene
SIO_000068: ncbigene

position:601661:1
position: 601661
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:604447:1
position: 604447
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:601661-604447:1:exon

YGR056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RSC1
locus tag: YGR056W
product: RSC subunit protein RSC1
transcript id: NM_001181185.1
SIO_010081: YGR056W
subclass of: SO_0000673
so part of: YGR056W
location: <601661..>604447
location: region:601661-604447:1
so has part: feature:601661-604447:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:601661-604447:1:exon

YGR056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RSC1
locus tag: YGR056W
experiment: EXISTENCE:curator inference:GO:0006338 chromatin remodeling [PMID:10619019]
experiment: EXISTENCE:curator inference:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10619019]
experiment: EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]
experiment: EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:17081996]
experiment: EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16024655]
experiment: EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]
note: Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication
codon start: 1
product: RSC subunit protein RSC1
translation: MVEQDNGFLQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPHYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKIVHNIRKHYPEVTYPSLGRIPEIFAESMQPSDLSSNPINTQENDEKAGLNPEMKMAFAKLDSSITERKPTNQDYRMQQKNSPAFPTHSASITPQPLASPTPVVNYANITSAHPKTHVRRGRPPVIDLPYVLRIKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNFNRLVRIELSKPDEDYLPEGELRYPLDDVEINDEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIRTWKACLPEELRDQDEPTIPVNGRKFFKYPSPIADLLPANATLNDKVPEPTEGAPTAPPLVGAVYLGPKLERDDLGEYSTSDDCPRYIIRPNDPPEEGKIDYETGTIITDTLTTSSMPRVNSSSTIRLPTLKQTKSIPSSNFRSSSNTPLLHQNFNQTSNFLKLENMNNSSHNLLSHPSVPKFQSPSLLEQSSRSKYHSAKKQTQLSSTAPKKPASKSFTLSSMINTLTAHTSKYNFNHIVIEAPGAFVVPVPMEKNIRTIQSTERFSRSNLKNAQNLGNTAINDINTANEQIIWFKGPGVKITERVIDSGNDLVRVPLNRWFCKNKRRKLDYEDIEEDVMEPPNDFSEDMIANIFNPPPSLNLDMDLNLSPSSNNSSNFMDLSTIASGDNDGKECDTAEESEDENEDTEDEHEIEDIPTTSAFGLNSSAEYLAFRLREFNKL
SIO_010081: YGR056W
subclass of: SO_0000673
so part of: YGR056W
location: 601661..604447
location: region:601661-604447:1
so has part: feature:601661-604447:1:exon

NP_011570.1
type: Protein
SIO_000068: ncbiprotein

S000003288
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:601661-604447:1:exon

YGR057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LST7
locus tag: YGR057C
so part of: sequence
location: complement(<604773..>605501)
location: region:604773-605501:-1
so has part: feature:604773-605501:-1:exon
subclass of: SO_0000010

852948
type: Gene
SIO_000068: ncbigene

position:604773:-1
position: 604773
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:605501:-1
position: 605501
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:604773-605501:-1:exon

YGR057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LST7
locus tag: YGR057C
product: Lst7p
transcript id: NM_001181186.3
SIO_010081: YGR057C
subclass of: SO_0000673
so part of: YGR057C
location: complement(<604773..>605501)
location: region:604773-605501:-1
so has part: feature:604773-605501:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:604773-605501:-1:exon

YGR057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LST7
locus tag: YGR057C
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:26387955]
experiment: EXISTENCE:direct assay:GO:1990877 FNIP-folliculin RagC/D GAP [PMID:26387955]
experiment: EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:26387955]
note: Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface
codon start: 1
product: Lst7p
translation: MSSTVISLAHFCDKHGPRIISVTQSAEKGTLGEELLVPDYPTESYCESCLLQFPEESTRSMRCFIEDVPFITTQYSSIRYQLLNSIIKRAFSEETMIYDNMPFIFFDDLRGLNLVIGFKLYDENARGNERRYCFILTVDSRSHDDSMKMLSEHWNFIIGGFDKMIAYIKNIHKSEFLGKNKTVENNLETLNNNAFIGSYLRANKSKFGRNLVSLTDDKFLFVRIHKWNSFLLHTVMNENKLP
SIO_010081: YGR057C
subclass of: SO_0000673
so part of: YGR057C
location: complement(604773..605501)
location: region:604773-605501:-1
so has part: feature:604773-605501:-1:exon

NP_011571.4
type: Protein
SIO_000068: ncbiprotein

S000003289
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:604773-605501:-1:exon

YGR058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PEF1
locus tag: YGR058W
so part of: sequence
location: <606136..>607143
location: region:606136-607143:1
so has part: feature:606136-607143:1:exon
subclass of: SO_0000010

852949
type: Gene
SIO_000068: ncbigene

position:606136:1
position: 606136
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:607143:1
position: 607143
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:606136-607143:1:exon

YGR058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PEF1
locus tag: YGR058W
product: Pef1p
transcript id: NM_001181187.2
SIO_010081: YGR058W
subclass of: SO_0000673
so part of: YGR058W
location: <606136..>607143
location: region:606136-607143:1
so has part: feature:606136-607143:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:606136-607143:1:exon

YGR058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PEF1
locus tag: YGR058W
experiment: EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]
experiment: EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:17640275]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22792405]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17640275]
experiment: EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:17640275]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:17640275]
experiment: EXISTENCE:mutant phenotype:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]
experiment: EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:17640275]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:17640275]
experiment: EXISTENCE:physical interaction:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]
note: Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
codon start: 1
product: Pef1p
translation: MCAKKLKYAAGDDFVRYATPKEAMEETRREFEKEKQRQQQIKVTQAQTPNTRVHSAPIPLQTQYNKNRAENGHHSYGSPQSYSPRHTKTPVDPRYNVIAQKPAGRPIPPAPTHYNNLNTSAQRIASSPPPLIHNQAVPAQLLKKVAPASFDSREDVRDMQVATQLFHNHDVKGKNRLTAEELQNLLQNDDNSHFCISSVDALINLFGASRFGTVNQAEFIALYKRVKSWRKVYVDNDINGSLTISVSEFHNSLQELGYLIPFEVSEKTFDQYAEFINRNGTGKELKFDKFVEALVWLMRLTKLFRKFDTNQEGIATIQYKDFIDATLYLGRFLPH
SIO_010081: YGR058W
subclass of: SO_0000673
so part of: YGR058W
location: 606136..607143
location: region:606136-607143:1
so has part: feature:606136-607143:1:exon

NP_011572.2
type: Protein
SIO_000068: ncbiprotein

S000003290
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:606136-607143:1:exon

YGR059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPR3
locus tag: YGR059W
so part of: sequence
location: <607563..>609101
location: region:607563-609101:1
so has part: feature:607563-609101:1:exon
subclass of: SO_0000010

852950
type: Gene
SIO_000068: ncbigene

position:607563:1
position: 607563
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:609101:1
position: 609101
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:607563-609101:1:exon

YGR059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPR3
locus tag: YGR059W
product: septin SPR3
transcript id: NM_001181188.3
SIO_010081: YGR059W
subclass of: SO_0000673
so part of: YGR059W
location: <607563..>609101
location: region:607563-609101:1
so has part: feature:607563-609101:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:607563-609101:1:exon

YGR059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPR3
locus tag: YGR059W
experiment: EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8636217]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18826657|PMID:24390141]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8636217]
note: Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes
codon start: 1
product: septin SPR3
translation: MKSKGSRLSTDCPVEFPKIVSGFAEEVKIRRQSSQGQYAVDSHPPKSPELKHRRQRSSSFVNGKCRNRDLPLLDNKKAQEINTNSHGQDIGIKNLPRQRELLNAKNGIDFTLMVAGQSGLGKTTFINSLFSTSLIDDDIKENKPIIRYKSIVEGDGTHLNFNVIDTPGFGNNMDNAFTWRTMVNYIDEEIRSYIFQEEQPDRTKMVDNRVHCCLYFLRPSNKGIDTLDVVTMKKLAKRVNLIPVIAKSDLLTKEELKNFKTQVREIIRVQDIPVCFFFGDEVLNATQDIFQKYPFSIIASNEYIFNEKGEKVKGRQYKWGAVDIENEKYCDFKILQKTIFDWNLIDLVESTEDYYEKCRSEMLRTRLLKARDCLTTKSVDITEEQRKFLEEEMNFDEIEENKLKNYKCYEIINKTVMDKVATEWDPEFITRQLEAKKKFNELSNREISKFRDWKKSLFMEQENFNQEIEQLNHKLENLQLECQDLEYKLLIGKSSNSHSTDSATLVNVHIKR
SIO_010081: YGR059W
subclass of: SO_0000673
so part of: YGR059W
location: 607563..609101
location: region:607563-609101:1
so has part: feature:607563-609101:1:exon

NP_011573.3
type: Protein
SIO_000068: ncbiprotein

S000003291
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:607563-609101:1:exon

YNCG0026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR48
locus tag: YNCG0026W
so part of: sequence
location: 609584..609696
location: region:609584-609696:1
so has part: feature:609584-609696:1:exon
subclass of: SO_0000578

9164898
type: Gene
SIO_000068: ncbigene

position:609584:1
position: 609584
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:609696:1
position: 609696
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:609584-609696:1:exon

YNCG0026W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR48
locus tag: YNCG0026W
product: SNR48
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at positions G2791 and G2793
transcript id: NR_132183.1
SIO_010081: YNCG0026W
subclass of: SO_0000673
so part of: YNCG0026W
location: 609584..609696
location: region:609584-609696:1
so has part: feature:609584-609696:1:exon

S000006440
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:609584-609696:1:exon

YGR060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ERG25
locus tag: YGR060W
so part of: sequence
location: <610564..>611493
location: region:610564-611493:1
so has part: feature:610564-611493:1:exon
subclass of: SO_0000010

852951
type: Gene
SIO_000068: ncbigene

position:610564:1
position: 610564
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:611493:1
position: 611493
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:610564-611493:1:exon

YGR060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ERG25
locus tag: YGR060W
product: methylsterol monooxygenase
transcript id: NM_001181189.3
SIO_010081: YGR060W
subclass of: SO_0000673
so part of: YGR060W
location: <610564..>611493
location: region:610564-611493:1
so has part: feature:610564-611493:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:610564-611493:1:exon

YGR060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ERG25
locus tag: YGR060W
experiment: EXISTENCE:direct assay:GO:0000254 C-4 methylsterol oxidase activity [PMID:8663358|PMID:12880870]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8663358]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8663358]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8663358|PMID:12880870]
experiment: EXISTENCE:mutant phenotype:GO:0000254 C-4 methylsterol oxidase activity [PMID:8552601]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8552601]
experiment: EXISTENCE:physical interaction:GO:0005783 endoplasmic reticulum [PMID:12119386]
note: C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression
codon start: 1
product: methylsterol monooxygenase
translation: MSAVFNNATLSGLVQASTYSQTLQNVAHYQPQLNFMEKYWAAWYSYMNNDVLATGLMFFLLHEFMYFFRCLPWFIIDQIPYFRRWKLQPTKIPSAKEQLYCLKSVLLSHFLVEAIPIWTFHPMCEKLGITVEVPFPSLKTMALEIGLFFVLEDTWHYWAHRLFHYGVFYKYIHKQHHRYAAPFGLSAEYAHPAETLSLGFGTVGMPILYVMYTGKLHLFTLCVWITLRLFQAVDSHSGYDFPWSLNKIMPFWAGAEHHDLHHHYFIGNYASSFRWWDYCLDTESGPEAKASREERMKKRAENNAQKKTN
SIO_010081: YGR060W
subclass of: SO_0000673
so part of: YGR060W
location: 610564..611493
location: region:610564-611493:1
so has part: feature:610564-611493:1:exon

NP_011574.3
type: Protein
SIO_000068: ncbiprotein

S000003292
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:610564-611493:1:exon

YGR061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ADE6
locus tag: YGR061C
so part of: sequence
location: complement(<611889..>615965)
location: region:611889-615965:-1
so has part: feature:611889-615965:-1:exon
subclass of: SO_0000010

852952
type: Gene
SIO_000068: ncbigene

position:611889:-1
position: 611889
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:615965:-1
position: 615965
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:611889-615965:-1:exon

YGR061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ADE6
locus tag: YGR061C
product: phosphoribosylformylglycinamidine synthase
transcript id: NM_001181190.1
SIO_010081: YGR061C
subclass of: SO_0000673
so part of: YGR061C
location: complement(<611889..>615965)
location: region:611889-615965:-1
so has part: feature:611889-615965:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:611889-615965:-1:exon

YGR061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ADE6
locus tag: YGR061C
EC number: 6.3.5.3
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004642 phosphoribosylformylglycinamidine synthase activity [PMID:9331966]
experiment: EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:1743513]
note: Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
codon start: 1
product: phosphoribosylformylglycinamidine synthase
translation: MTDYILPGPKALSQFRVDNLIKDINSYTNSTSVINELRSCYIHYVNGIAQNLSEQDTKLLEVLLTYDSALDIANDPLARQLNDAVANNLPSSALGEDTYLIRVVPRSGTISPWSSKATNIAHVCGLQDKVQRIERGLALLIKTVPGFPLLENLNDISLKCVYDRMTQQLYLTEPPNTMSIFTHEEPKPLVHVPLTPKDTKQSPKDILSKANTELGLALDSGEMEYLIHAFVETMKRDPTDVELFMFAQVNSEHCRHKIFNADWTIDGIKQQFTLFQMIRNTHKLNPEYTISAYSDNAAVLDSENDAFFFAPNSTTKEWTSTKERIPLLIKVETHNHPTAVSPFPGAATGSGGEIRDEGATGRGSKTKCGLSGFSVSDLLIPGNEQPWELNIGKPYHIASALDIMIEAPLGSAAFNNEFGRPCINGYFRTLTTKVLNHQGKEEIRGFHKPIMIAGGFGTVRPQFALKNTPITPGSCLIVLGGQSMLIGLGGGAASSVASGEGSADLDFASVQRGNPEMERRCQQVIDACVALGNNNPIQSIHDVGAGGLSNALPELVHDNDLGAKFDIRKVLSLEPGMSPMEIWCNESQERYVLGVSPQDLSIFEEICKRERAPFAVVGHATAEQKLIVEDPLLKTTPIDLEMPILFGKPPKMSRETITEALNLPEANLSEIPSLQDAIQRVLNLPSVGSKSFLITIGDRSVTGLIDRDQFVGPWQVPVADVGVTGTSLGETIISTGEAMAMGEKPVNALISASASAKLSVAESLLNIFAADVKSLNHIKLSANWMSPASHQGEGSKLYEAVQALGLDLCPALGVAIPVGKDSMSMKMKWDDKEVTAPLSLNITAFAPVFNTSKTWTPLLNRNTDDSVLVLVDLSAKQETKSLGASALLQVYNQVGNKSPTVYDNAILKGFLESLIQLHQQKEDIVLAYHDRSDGGLLITLLEMAFASRCGLEINIDGGDLESQLTNLFNEELGAVFQISAKNLSKFEKILNENGVAKEYISIVGKPSFQSQEIKIINSTTNDVIYANSRSELEQTWSKTSYEMQKLRDNPKTAEEEFASITDDRDPGLQYALTYNPADDMKIGLELSSQRPKVAILREQGVNGQMEMAWCFQQAGFNSVDVTMTDLLEGRFHLDDFIGLAACGGFSYGDVLGAGAGWAKSVLYHEGVRSQFSKFFNERQDTFAFGACNGCQFLSRLKDIIPGCENWPSFERNVSEQYEARVCMVQISQEKDNSSEESVFLNGMAGSKLPIAVAHGEGKATFSKSAEQLEKFEKDGLCCIRYVDNYGNVTERFPFNPNGSTNGIAGIKSPNGRVLAMMPHPERVCRLEANSWYPEGKYEEWGGYGPWIRLFRSARRWVG
SIO_010081: YGR061C
subclass of: SO_0000673
so part of: YGR061C
location: complement(611889..615965)
location: region:611889-615965:-1
so has part: feature:611889-615965:-1:exon

NP_011575.1
type: Protein
SIO_000068: ncbiprotein

S000003293
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:611889-615965:-1:exon

YGR062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: OXA2
gene: COX18
locus tag: YGR062C
gene synonym: OXA2
so part of: sequence
location: complement(<616328..>617278)
location: region:616328-617278:-1
so has part: feature:616328-617278:-1:exon
subclass of: SO_0000010

852953
type: Gene
SIO_000068: ncbigene

position:616328:-1
position: 616328
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:617278:-1
position: 617278
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:616328-617278:-1:exon

YGR062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: OXA2
gene: COX18
locus tag: YGR062C
gene synonym: OXA2
product: membrane insertase COX18
transcript id: NM_001181191.1
SIO_010081: YGR062C
subclass of: SO_0000673
so part of: YGR062C
location: complement(<616328..>617278)
location: region:616328-617278:-1
so has part: feature:616328-617278:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:616328-617278:-1:exon

YGR062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: OXA2
gene: COX18
locus tag: YGR062C
gene synonym: OXA2
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11950926]
experiment: EXISTENCE:genetic interaction:GO:0032977 membrane insertase activity [PMID:17922846]
experiment: EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926|PMID:17922846]
experiment: EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:11950926]
experiment: EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]
experiment: EXISTENCE:physical interaction:GO:0032977 membrane insertase activity [PMID:17452441]
experiment: EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:17452441]
note: Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p
codon start: 1
product: membrane insertase COX18
translation: MLKRLANRQNGFASFSCSSVGLRYGRTNPSTKRSFSLFQSVADTFLTVHEASHIPWIVLVPLTTMTLRTLVTLPFSIWQRRRILKQQELRKLVQPITPIIKLRLAAVTNKKSRNAARISSNGSFMPLQLQNAGVLTPEQITLLAVKETRKRQKKLFKKYNVPLWKNALLPMVQIPLWVTVSMGIRTLTETQLIESFYPSWFSALGFSSFDLSSPLVAMPLLAPILVGTLAVLNVELNGRLMFSSSLSSQGIKTISRNSTRVQEAMTSILNVSRLGCVVMLAMSSQAPFLLSLYWISSQLFSLVQNIILNWIYPYQR
SIO_010081: YGR062C
subclass of: SO_0000673
so part of: YGR062C
location: complement(616328..617278)
location: region:616328-617278:-1
so has part: feature:616328-617278:-1:exon

NP_011576.1
type: Protein
SIO_000068: ncbiprotein

S000003294
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:616328-617278:-1:exon

YGR063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPT4
locus tag: YGR063C
so part of: sequence
location: complement(<617516..>617824)
location: region:617516-617824:-1
so has part: feature:617516-617824:-1:exon
subclass of: SO_0000010

852955
type: Gene
SIO_000068: ncbigene

position:617516:-1
position: 617516
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:617824:-1
position: 617824
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:617516-617824:-1:exon

YGR063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPT4
locus tag: YGR063C
product: transcription elongation factor SPT4
transcript id: NM_001181192.3
SIO_010081: YGR063C
subclass of: SO_0000673
so part of: YGR063C
location: complement(<617516..>617824)
location: region:617516-617824:-1
so has part: feature:617516-617824:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:617516-617824:-1:exon

YGR063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPT4
locus tag: YGR063C
experiment: EXISTENCE:curator inference:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:16908835]
experiment: EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:16908835]
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:15057281]
experiment: EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:27376968]
experiment: EXISTENCE:direct assay:GO:0031934 mating-type region heterochromatin [PMID:15057281]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:26945063]
experiment: EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:16908835]
experiment: EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:26945063]
experiment: EXISTENCE:genetic interaction:GO:0006370 7-methylguanosine mRNA capping [PMID:12556496]
experiment: EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:20042611]
experiment: EXISTENCE:genetic interaction:GO:2001208 negative regulation of transcription elongation by RNA polymerase I [PMID:21467039]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15057281]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:9450930]
experiment: EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:20713510]
experiment: EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:31462158]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:15057281]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12554661]
experiment: EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:21949810]
experiment: EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:16908835]
experiment: EXISTENCE:physical interaction:GO:0032044 DSIF complex [PMID:9450930]
note: Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions
codon start: 1
product: transcription elongation factor SPT4
translation: MSSERACMLCGIVQTTNEFNRDGCPNCQGIFEEAGVSTMECTSPSFEGLVGMCKPTKSWVAKWLSVDHSIAGMYAIKVDGRLPAEVVELLPHYKPRDGSQVE
SIO_010081: YGR063C
subclass of: SO_0000673
so part of: YGR063C
location: complement(617516..617824)
location: region:617516-617824:-1
so has part: feature:617516-617824:-1:exon

NP_011577.3
type: Protein
SIO_000068: ncbiprotein

S000003295
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:617516-617824:-1:exon

YGR065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VHT1
locus tag: YGR065C
so part of: sequence
location: complement(<618077..>619858)
location: region:618077-619858:-1
so has part: feature:618077-619858:-1:exon
subclass of: SO_0000010

852956
type: Gene
SIO_000068: ncbigene

position:618077:-1
position: 618077
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:619858:-1
position: 619858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:618077-619858:-1:exon

YGR065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VHT1
locus tag: YGR065C
product: Vht1p
transcript id: NM_001181194.1
SIO_010081: YGR065C
subclass of: SO_0000673
so part of: YGR065C
location: complement(<618077..>619858)
location: region:618077-619858:-1
so has part: feature:618077-619858:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:618077-619858:-1:exon

YGR065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VHT1
locus tag: YGR065C
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10373489]
experiment: EXISTENCE:direct assay:GO:0015225 biotin transmembrane transporter activity [PMID:10373489]
experiment: EXISTENCE:direct assay:GO:0015878 biotin transport [PMID:10373489]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
codon start: 1
product: Vht1p
translation: MTISNKSWRSYFPHLRKLPEDDQYLYSDDTNSSIIAEEELHHSVDKSSKTDVTAETTAVEPHPHNLRHDLPYEVRDEAGRKWWKYFDEFEYRVNKEYKKSRKWYEFLYPNHTTQTKAERRLLYKLDIIIALYFFMLCWSKSVDLNNYTNAYVSNMKEDLNMKGNDYVYTSTIANVGAIVFQLPFMYLLPRFPSHIILPVMDLGWTWFTFACYRANSLAELRAYRFILSAFGAAYYPVSQYILGCWYAPDEINSRVCLFFCGQQLGSVTSGLLQSRIFKSLNGVHGLAGWRWMFLIDAIAISLPTAIIGFFVIPGVPSKCYSLFLTDEEIRIARARNKRNQIKDGVDKSKLAPLWSRKLWKKVFCTPAFWVLVVFDTCSWNNMTAYSGSYTLWLKSNTKYSIAQVNNLSVIPACLGFAYVIFCAFGADLFRCKWIFMVFAAIMNTVSCALLIKWDIPSKAKWYAFFTTYFSVAASPCLWSFINDFLRFDPQVKAITWIAIYSFSQSTYAWIPTLAWPTVESPRFKTGYTVSLIFGAIYGLWTFVVLFFYKRNEKKHALGNGIILYDSNKGEELPEFVKKNMEERDGYYYLKRSS
SIO_010081: YGR065C
subclass of: SO_0000673
so part of: YGR065C
location: complement(618077..619858)
location: region:618077-619858:-1
so has part: feature:618077-619858:-1:exon

NP_011579.1
type: Protein
SIO_000068: ncbiprotein

S000003297
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:618077-619858:-1:exon

YGR066C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GID10
locus tag: YGR066C
so part of: sequence
location: complement(<620921..>621799)
location: region:620921-621799:-1
so has part: feature:620921-621799:-1:exon
subclass of: SO_0000010

852957
type: Gene
SIO_000068: ncbigene

position:620921:-1
position: 620921
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:621799:-1
position: 621799
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:620921-621799:-1:exon

YGR066C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GID10
locus tag: YGR066C
product: Gid10p
transcript id: NM_001181195.3
SIO_010081: YGR066C
subclass of: SO_0000673
so part of: YGR066C
location: complement(<620921..>621799)
location: region:620921-621799:-1
so has part: feature:620921-621799:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:620921-621799:-1:exon

YGR066C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GID10
locus tag: YGR066C
experiment: EXISTENCE:direct assay:GO:0006970 response to osmotic stress [PMID:31337681]
experiment: EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:31337681]
experiment: EXISTENCE:direct assay:GO:0034657 GID complex [PMID:31337681]
experiment: EXISTENCE:direct assay:GO:0042594 response to starvation [PMID:31337681]
note: Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress
codon start: 1
product: Gid10p
translation: MTSLNIMGRKFILERAKRNDNIEEIYTSAYVSLPSSTDTRLPHFKAKEEDCDVYEEGTNLVGKNAKYTYRSLGRHLDFLRPGLRFGGSQSSKYTYYTVEVKIDTVNLPLYKDSRSLDPHVTGTFTIKNLTPVLDKVVTLFEGYVINYNQFPLCSLHWPAEETLDPYMAQRESDCSHWKRFGHFGSDNWSLTERNFGQYNHESAEFMNQRYIYLKWKERFLLDDEEQENLMLDDNHHLEGASFEGFYYVCLDQLTGSVEGYYYHPACELFQKLELVPTNCDALNTYSSGFEIA
SIO_010081: YGR066C
subclass of: SO_0000673
so part of: YGR066C
location: complement(620921..621799)
location: region:620921-621799:-1
so has part: feature:620921-621799:-1:exon

NP_011580.3
type: Protein
SIO_000068: ncbiprotein

S000003298
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:620921-621799:-1:exon

YGR067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YGR067C
so part of: sequence
location: complement(<622372..>624786)
location: region:622372-624786:-1
so has part: feature:622372-624786:-1:exon
subclass of: SO_0000010

852958
type: Gene
SIO_000068: ncbigene

position:622372:-1
position: 622372
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:624786:-1
position: 624786
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:622372-624786:-1:exon

YGR067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YGR067C
product: uncharacterized protein
transcript id: NM_001181196.4
SIO_010081: YGR067C
subclass of: SO_0000673
so part of: YGR067C
location: complement(<622372..>624786)
location: region:622372-624786:-1
so has part: feature:622372-624786:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:622372-624786:-1:exon

YGR067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YGR067C
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]
note: hypothetical protein; contains a zinc finger motif similar to that of Adr1p
codon start: 1
product: uncharacterized protein
translation: MAAGQKKYICSFCLKPFSRSEHKIRHERSHAGVKPFQCQVCKHSFVRRDLLQRHIRTVHRTFLLSSYASMTGDKADIPVSLGVGDVDSTSPRDIKMETLVNSMIKVNSGLINIHYHSSNVEKMDKQQRCVIGKESSSLKKGKSRFKQVKSRLESSISVKILQEYSLDFISSRDILTFFRMGVSHLVENKIFQNFFPDLFSSLQNDELVESFWINKPFGLIIACLGMSISLNQDSQKLWFICCTNLYASSSKHDNDFDTEDILSQTEQHDVFALILFYSLLVMLENNIPVSNSIKKFDVFSMLQDILKPFTVASSSYHYLNSKENAWFIFDLWVNILRDSNNFNNDSLLIFGWFVNQEFISSNPLKDFIYKGPSMSTTDLTLKHINILADSAYVYFIIKKTYPQELPSDFRVHDLLVYLNECFVMQQPIKPETSANPSLFANVMNARITDCKSKSNWLLWETIWFEFINNLTLRNGTTRNIWFIDNFPQVSTSCLLHHSSSFVDETLITTNLSIISMLLNLKSFTLASLNPRNIQLITDIVSFQLKLFSSELIASSDVSPSQVSQLLVNPNVHLMLYFWFDTIYVQRQSYLSSTEKEEFEKVEVFVNDYIITHQKNLVTDLHSILFDFWSDSFIAYHILLHAIVSSLRDNILYPYLIYSPHLNDQTKALLTDISNWSCFALQQPFRKTSRGSLSGASDMKSFSVASCLPLSPNFLKRDSNCNKILLPPLDIKAIEPISTSNYTYVNSAPKQQEKEQPLLRATGNNINLVQTIVVPPQVNMESQEFSASSTDNKQSKNIEIFSQIK
SIO_010081: YGR067C
subclass of: SO_0000673
so part of: YGR067C
location: complement(622372..624786)
location: region:622372-624786:-1
so has part: feature:622372-624786:-1:exon

NP_011581.4
type: Protein
SIO_000068: ncbiprotein

S000003299
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:622372-624786:-1:exon

YGR068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ART5
locus tag: YGR068C
so part of: sequence
location: complement(<625324..>627084)
location: region:625324-627084:-1
so has part: feature:625324-627084:-1:exon
subclass of: SO_0000010

852960
type: Gene
SIO_000068: ncbigene

position:625324:-1
position: 625324
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:627084:-1
position: 627084
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:625324-627084:-1:exon

YGR068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ART5
locus tag: YGR068C
product: Art5p
transcript id: NM_001181197.1
SIO_010081: YGR068C
subclass of: SO_0000673
so part of: YGR068C
location: complement(<625324..>627084)
location: region:625324-627084:-1
so has part: feature:625324-627084:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:625324-627084:-1:exon

YGR068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ART5
locus tag: YGR068C
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]
note: Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol
codon start: 1
product: Art5p
translation: MFSLSSLSSSGGHSEQKERERISYFDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVKNEIVVKKISLRLVGRFKLEFLQVGRYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVLVGGENAENQHNSSSGRSTSNQDMDTSGNAIFLSKRSLSSPVFNKIIRRKTHSSHRKILELPENGVTGTPFEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKITHLADFGPLTDKLDVDCPFTIPDNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKGRLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPPPNYHESTNDHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGSVPAYCDDD
SIO_010081: YGR068C
subclass of: SO_0000673
so part of: YGR068C
location: complement(625324..627084)
location: region:625324-627084:-1
so has part: feature:625324-627084:-1:exon

NP_011582.1
type: Protein
SIO_000068: ncbiprotein

S000003300
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:625324-627084:-1:exon

YGR070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SKC1
gene: ROM1
locus tag: YGR070W
gene synonym: SKC1
so part of: sequence
location: <627806..>631273
location: region:627806-631273:1
so has part: feature:627806-631273:1:exon
subclass of: SO_0000010

852961
type: Gene
SIO_000068: ncbigene

position:627806:1
position: 627806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:631273:1
position: 631273
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:627806-631273:1:exon

YGR070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SKC1
gene: ROM1
locus tag: YGR070W
gene synonym: SKC1
product: Rho family guanine nucleotide exchange factor ROM1
transcript id: NM_001181199.2
SIO_010081: YGR070W
subclass of: SO_0000673
so part of: YGR070W
location: <627806..>631273
location: region:627806-631273:1
so has part: feature:627806-631273:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:627806-631273:1:exon

YGR070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SKC1
gene: ROM1
locus tag: YGR070W
gene synonym: SKC1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22065638]
experiment: EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8641285]
experiment: EXISTENCE:genetic interaction:GO:0007264 small GTPase mediated signal transduction [PMID:8641285]
experiment: EXISTENCE:genetic interaction:GO:0090630 activation of GTPase activity [PMID:8641285]
note: Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication
codon start: 1
product: Rho family guanine nucleotide exchange factor ROM1
translation: MNSNELDLRNKYFYEIFGKKRKSDTSTPTQLFSGSKVQTNINEISITNDEDEDSTEDENKASLKDYTLGHDTGARYRIAPDCSSHQLKASPVLHISTNLNSSPQSFTGDQISPTNKKISINDSTRQDKGNSCTTTSSPSQKRSNVLLPHVRKHSSPSLLSFSKNSGSHMGDPNQLSTPPTPKSAGHTMELHSSFNGKHSSSSTSSLFALESLKTQNRRSSNSSNHSSQYRRHTNQHQRHHSRSKSSPVSLTEISMIKGTPLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFTGKQAIDTLCLIIGSLDRNLGMLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSIANTFSSSSSSVNSLRTKTEIYGVFVPLTHCYSSTCSLEKLCYSISCPNRLQQQANLHLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNPNFARFDDEVSNSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQMLMKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICPAEDMPPIKRYVTENPNCSAGVLLPQYQTSNPKNAIVFAYYGTKQQYQVTLYAPQPAGLQTLIEKVKQEQKRLLDETKHITFKQMVGQFFHSYINTNRVNDVLICHAGKILLVATNMGLFVLNYATSINQKPVHLLHKISISQISVLEEYKVMILLIDKKLYGCPLDVIDDAENADFLFRKNSKVLFKYVAMFKDGFCNGKRIIMIAHHFLHAVQLLIVNPLIFDFNSGNFKKNLKAGLVDFSVDSEPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFKMRELLNLHDNKVLANMYKETFKVVSMFPIKNSTFACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEIRHIENGELVRCVLGNKIRMLKSYAKKILYCYEDPQGFEIIELLNF
SIO_010081: YGR070W
subclass of: SO_0000673
so part of: YGR070W
location: 627806..631273
location: region:627806-631273:1
so has part: feature:627806-631273:1:exon

NP_011584.2
type: Protein
SIO_000068: ncbiprotein

S000003302
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:627806-631273:1:exon

YGR071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ENV11
locus tag: YGR071C
so part of: sequence
location: complement(<631481..>634063)
location: region:631481-634063:-1
so has part: feature:631481-634063:-1:exon
subclass of: SO_0000010

852962
type: Gene
SIO_000068: ncbigene

position:631481:-1
position: 631481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:634063:-1
position: 634063
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:631481-634063:-1:exon

YGR071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ENV11
locus tag: YGR071C
product: Env11p
transcript id: NM_001181200.3
SIO_010081: YGR071C
subclass of: SO_0000673
so part of: YGR071C
location: complement(<631481..>634063)
location: region:631481-634063:-1
so has part: feature:631481-634063:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:631481-634063:-1:exon

YGR071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ENV11
locus tag: YGR071C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]
experiment: EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:21912603]
note: Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication
codon start: 1
product: Env11p
translation: MNTALDDLHGDLVTLEDNEIINNSDHSSSHSTSHEEEDEEEDDTEDIELIEKDGNKILSSRIHPEDEIINDGLNIWIPVQMLKKNIAKFWSHFLAIEKKLTKVKCKHCGEILTRSDASLTKTFRSHLKTKHNISANKNFYSMNFTVGDSNLKNNTSSTEITRRHGYDSLTFNSDQSFKCFDIGKLQSSNYLSISQLVAIVIASENLPLNFFENVSFKSLLSKFHRIPPLTTNIIEESIIGLSKSIDELIRRSISRNDTQLPFTIHLSDSKESNQPLYLKYSREIRAQLSNLDLSHLISVNFTELAGKRSLFSLQLFDNTNKVSKGLPLSIFVRKTTDIDISVWQEQLNNLYSKYPGLQKSVISITLPQSHYTMVLENRNSHNFTFHSGSVREIKYHTCIVSELLHCFLQPLFNVPTESMLSSFSVAKENHSGGSLLDSLIDFSHIDLSSTILGKICCLIEEVNLNDSLKSDFLLYCQNYTQPNCNELTSILSCNCDRFSALKSILEKFANLVPFFKSINSHLENESLSESDFRLINTVEETLRTFEQSIEYFASSAPLKFTHTLVFIIKFELYLTEIIRSFKFTKSKKPFEKILARLLKVKDLYLLDDVNLIGAFLYPSIFQSKSLLNEIFGTTSVNKIVHNMTKIVLRYLKNFINITNFRSSNSGGESGRNSGNNLLSDYEAIFMKESRDVELLCNTKLTAPLTEDSLLVQIIRDDLLRYVNRIAHELPNAYHDYLNDNDISFDGSHFTKHELSEENDSNSGEWCLNPMEETFDIHIPISDSIWNNYISSKNKIEVIDILLQLLSVNSTSSIRSELSSLTANQDFSTKLSEETIKIKLLNSQFNLEKINFHSGSIFDAC
SIO_010081: YGR071C
subclass of: SO_0000673
so part of: YGR071C
location: complement(631481..634063)
location: region:631481-634063:-1
so has part: feature:631481-634063:-1:exon

NP_011585.3
type: Protein
SIO_000068: ncbiprotein