Saccharomyces cerevisiae S288C chromosome V, complete sequence.
type: Entry
definition: Saccharomyces cerevisiae S288C chromosome V, complete sequence.
sequence version: NC_001137.3
sequence date: 2023-01-18
sequence: sequence
division: CON
label: NC_001137.3
type: RefSeq
SIO_000068: refseq
dblink: PRJNA128
keyword: RefSeq
source: Saccharomyces cerevisiae S288C
organism: Saccharomyces cerevisiae S288C
taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
reference: 1
references: 34897464
reference: 2
references: 9169868
reference: 3
references: 8849441
reference: 4
reference: 5
reference: 6
reference: 7
reference: 8
reference: 9
comment: REVIEWED REFSEQ: This record has been curated by SGD. The reference\nsequence is identical to BK006939.\n\nOn Apr 26, 2011 this sequence version replaced NC_001137.2.\n\n##Genome-Annotation-Data-START##\nAnnotation Provider :: SGD\nAnnotation Status :: Full Annotation\nAnnotation Version :: R64-3-1\nURL :: http://www.yeastgenome.org/\n##Genome-Annotation-Data-END##\nCOMPLETENESS: full length.

sequence
subclass of: SO_0000340
sequence length: 576874
topology: linear
so has quality: SO_0000987
location: 1..576874
location: region:1-576874:1
RO_0002162: 559292

NC_001137
type: RefSeq
SIO_000068: refseq

PRJNA128
type: BioProject
SIO_000068: bioproject

1
title: New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources
author: Engel, S.R.
author: Wong, E.D.
author: Nash, R.S.
author: Aleksander, S.
author: Alexander, M.
author: Douglass, E.
author: Karra, K.
author: Miyasato, S.R.
author: Simison, M.
author: Skrzypek, M.S.
author: Weng, S.
author: Cherry, J.M.
journal: Genetics 220 (4) (2022)
pubmed: 34897464

34897464
type: PubMed
SIO_000068: pubmed

2
title: The nucleotide sequence of Saccharomyces cerevisiae chromosome V
author: Dietrich, F.S.
author: Mulligan, J.
author: Hennessy, K.
author: Yelton, M.A.
author: Allen, E.
author: Araujo, R.
author: Aviles, E.
author: Berno, A.
author: Brennan, T.
author: Carpenter, J.
author: Chen, E.
author: Cherry, J.M.
author: Chung, E.
author: Duncan, M.
author: Guzman, E.
author: Hartzell, G.
author: Hunicke-Smith, S.
author: Hyman, R.W.
author: Kayser, A.
author: Komp, C.
author: Lashkari, D.
author: Lew, H.
author: Lin, D.
author: Mosedale, D.
author: Davis, R.W. et al.
journal: Nature 387 (6632 SUPPL), 78-81 (1997)
pubmed: 9169868

9169868
type: PubMed
SIO_000068: pubmed

3
title: Life with 6000 genes
author: Goffeau, A.
author: Barrell, B.G.
author: Bussey, H.
author: Davis, R.W.
author: Dujon, B.
author: Feldmann, H.
author: Galibert, F.
author: Hoheisel, J.D.
author: Jacq, C.
author: Johnston, M.
author: Louis, E.J.
author: Mewes, H.W.
author: Murakami, Y.
author: Philippsen, P.
author: Tettelin, H.
author: Oliver, S.G.
journal: Science 274 (5287), 546 (1996)
pubmed: 8849441

8849441
type: PubMed
SIO_000068: pubmed

4
title: Direct Submission
journal: Submitted (13-JAN-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

5
title: Direct Submission
journal: Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

6
title: Direct Submission
journal: Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

7
title: Direct Submission
journal: Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Protein update by submitter

8
title: Direct Submission
journal: Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
comments: Sequence update by submitter

9
title: Direct Submission
journal: Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA

position:1:1
position: 1
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:576874:1
position: 576874
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

feature:1-576874:1:source
so part of: sequence
organism: Saccharomyces cerevisiae S288C
mol type: genomic DNA
strain: S288C
chromosome: V

559292
type: Taxonomy
SIO_000068: taxonomy

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL05L; Telomeric region on the left arm of Chromosome V; annotated components include an X element core sequence and a long Y' element; TEL05L does have telomeric repeats (TEL05L-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly
so part of: sequence
location: complement(1..6473)
location: region:1-6473:-1
so has part: feature:1-6473:-1:region

S000028879
type: SGD
SIO_000068: sgd

position:1:-1
position: 1
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:6473:-1
position: 6473
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:1-6473:-1:region

YEL077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL077C
so part of: sequence
location: complement(<264..>4097)
location: region:264-4097:-1
so has part: feature:264-4097:-1:exon
subclass of: SO_0000010

856630
type: Gene
SIO_000068: ncbigene

position:264:-1
position: 264
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:4097:-1
position: 4097
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264-4097:-1:exon

YEL077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL077C
product: Y' element ATP-dependent helicase
transcript id: NM_001184302.1
SIO_010081: YEL077C
subclass of: SO_0000673
so part of: YEL077C
location: complement(<264..>4097)
location: region:264-4097:-1
so has part: feature:264-4097:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264-4097:-1:exon

YEL077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL077C
EC number: 3.6.4.12
note: Helicase-like protein encoded within the telomeric Y' element
codon start: 1
product: Y' element ATP-dependent helicase
translation: MTLGNSYDAFNHDPWMDVVGFEDPNQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCYEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIRKKVESQPEEALKLLLALFESEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLDAAEKVSRTKEFVTDGNMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSNFQESNSSDRYRKYCSSDEDSNTCIHGSANASTNASTNAITTASTNVRTNATTNASTNATTNASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASINVRTSATTTKSINSSTNATITESTNSNTNATTTESTNSKTSATTTASTNSNTSATTTESTNSKTSATTTASTNSNTSATTTESTNSNTSATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRREIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCQEEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQIALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTKVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
SIO_010081: YEL077C
subclass of: SO_0000673
so part of: YEL077C
location: complement(264..4097)
location: region:264-4097:-1
so has part: feature:264-4097:-1:exon

NP_010835.1
type: Protein
SIO_000068: ncbiprotein

S000006409
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264-4097:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS502; Autonomously Replicating Sequence
so part of: sequence
location: 4097..4185
location: region:4097-4185:1
so has part: feature:4097-4185:1:region

S000077377
type: SGD
SIO_000068: sgd

position:4097:1
position: 4097
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:4185:1
position: 4185
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4097-4185:1:region

YEL076C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL076C-A
so part of: sequence
location: complement(<4185..>5114)
location: region:4185-5114:-1
so has part: feature:4185-5114:-1:exon
subclass of: SO_0000010

856632
type: Gene
SIO_000068: ncbigene

position:4185:-1
position: 4185
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5114:-1
position: 5114
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4185-5114:-1:exon

YEL076C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL076C-A
product: uncharacterized protein
transcript id: NM_001180855.1
SIO_010081: YEL076C-A
subclass of: SO_0000673
so part of: YEL076C-A
location: complement(join(<4185..4322,4602..>5114))
location: region:4185-5114:-1
so has part: feature:4602-5114:-1:exon
so has part: feature:4185-4322:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:4602-5114:-1:exon

position:4602:-1
position: 4602
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:4185-4322:-1:exon

position:4322:-1
position: 4322
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YEL076C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL076C-A
codon start: 1
product: uncharacterized protein
translation: MQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETTLKDSYRITLVPSSDGISDTLTVIQSFSYSLLPVLSATYTSMIQQDASNCTLITTRTVHRSLD
SIO_010081: YEL076C-A
subclass of: SO_0000673
so part of: YEL076C-A
location: complement(join(4185..4322,4602..5114))
location: region:4185-5114:-1
so has part: feature:4602-5114:-1:exon
so has part: feature:4185-4322:-1:exon

NP_010836.1
type: Protein
SIO_000068: ncbiprotein

S000002955
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:4602-5114:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:4185-4322:-1:exon

YEL076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL076C
so part of: sequence
location: complement(<4464..>5114)
location: region:4464-5114:-1
so has part: feature:4464-5114:-1:exon
subclass of: SO_0000010

856633
type: Gene
SIO_000068: ncbigene

position:4464:-1
position: 4464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:4464-5114:-1:exon

YEL076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL076C
product: uncharacterized protein
transcript id: NM_001178891.1
SIO_010081: YEL076C
subclass of: SO_0000673
so part of: YEL076C
location: complement(<4464..>5114)
location: region:4464-5114:-1
so has part: feature:4464-5114:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:4464-5114:-1:exon

YEL076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL076C
codon start: 1
product: uncharacterized protein
translation: MQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETTLKDSYRITLVPSSDGISVCGKLWGELNNCFHMPASFCVIEKFCSENRSEELTSIWKTILFFK
SIO_010081: YEL076C
subclass of: SO_0000673
so part of: YEL076C
location: complement(4464..5114)
location: region:4464-5114:-1
so has part: feature:4464-5114:-1:exon

NP_010837.1
type: Protein
SIO_000068: ncbiprotein

S000000802
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:4464-5114:-1:exon

YEL075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL075C
so part of: sequence
location: complement(<5345..>5713)
location: region:5345-5713:-1
so has part: feature:5345-5713:-1:exon
subclass of: SO_0000010

856634
type: Gene
SIO_000068: ncbigene

position:5345:-1
position: 5345
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:5713:-1
position: 5713
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:5345-5713:-1:exon

YEL075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL075C
product: uncharacterized protein
transcript id: NM_001178890.1
SIO_010081: YEL075C
subclass of: SO_0000673
so part of: YEL075C
location: complement(<5345..>5713)
location: region:5345-5713:-1
so has part: feature:5345-5713:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:5345-5713:-1:exon

YEL075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL075C
codon start: 1
product: uncharacterized protein
translation: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKVVISVMVGKNVKKFLTFVEDEPDFQGGPIPSNKPRDGLHVVSSAYFEIQ
SIO_010081: YEL075C
subclass of: SO_0000673
so part of: YEL075C
location: complement(5345..5713)
location: region:5345-5713:-1
so has part: feature:5345-5713:-1:exon

NP_010839.1
type: Protein
SIO_000068: ncbiprotein

S000000801
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:5345-5713:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS503; Autonomously Replicating Sequence
so part of: sequence
location: 6378..6453
location: region:6378-6453:1
so has part: feature:6378-6453:1:region

S000077378
type: SGD
SIO_000068: sgd

position:6378:1
position: 6378
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:6453:1
position: 6453
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:6378-6453:1:region

YEL073C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL073C
so part of: sequence
location: complement(<7230..>7553)
location: region:7230-7553:-1
so has part: feature:7230-7553:-1:exon
subclass of: SO_0000010

856636
type: Gene
SIO_000068: ncbigene

position:7230:-1
position: 7230
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:7553:-1
position: 7553
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:7230-7553:-1:exon

YEL073C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL073C
product: uncharacterized protein
transcript id: NM_001178888.1
SIO_010081: YEL073C
subclass of: SO_0000673
so part of: YEL073C
location: complement(<7230..>7553)
location: region:7230-7553:-1
so has part: feature:7230-7553:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:7230-7553:-1:exon

YEL073C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL073C
note: hypothetical protein; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
codon start: 1
product: uncharacterized protein
translation: MVNLANVLTNATAATLSAWSNTVPLETYFHFDEASGFGDYYLNVSVIWMNETLYETRIVPAIINVREWLDHMEANDPSPSVTNPYETSGYYAFSTVVPVLMGNMKVA
SIO_010081: YEL073C
subclass of: SO_0000673
so part of: YEL073C
location: complement(7230..7553)
location: region:7230-7553:-1
so has part: feature:7230-7553:-1:exon

NP_010841.1
type: Protein
SIO_000068: ncbiprotein

S000000799
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:7230-7553:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS504; Autonomously Replicating Sequence
so part of: sequence
location: 8786..10019
location: region:8786-10019:1
so has part: feature:8786-10019:1:region

S000077379
type: SGD
SIO_000068: sgd

position:8786:1
position: 8786
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:10019:1
position: 10019
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:8786-10019:1:region

YEL072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RMD6
locus tag: YEL072W
so part of: sequence
location: <13720..>14415
location: region:13720-14415:1
so has part: feature:13720-14415:1:exon
subclass of: SO_0000010

856637
type: Gene
SIO_000068: ncbigene

position:13720:1
position: 13720
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:14415:1
position: 14415
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:13720-14415:1:exon

YEL072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RMD6
locus tag: YEL072W
product: Rmd6p
transcript id: NM_001178887.1
SIO_010081: YEL072W
subclass of: SO_0000673
so part of: YEL072W
location: <13720..>14415
location: region:13720-14415:1
so has part: feature:13720-14415:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:13720-14415:1:exon

YEL072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RMD6
locus tag: YEL072W
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
note: Protein required for sporulation; localizes to the peroxisome
codon start: 1
product: Rmd6p
translation: MSACPCNIVILPVEILKNSSKDTKYSLYTTINRGYDVPRLKYGIIVSPRVHSLETLFSDLGFDKNIEKSSLYLLLNDPTLAYPNFHEHFEQLKGETNKDLSLPTYYIPKVQFLTEAFDSEHTLATIGYKPNNKESYEITGFTSMGNGYGIKLFNYSVIHMMRSHKCKRVVADIIMEHDLLGYYEKKLGFVEVQRFKVLKEQHQVKVFDDKVDFTKDFHVIKMIKELGNHRL
SIO_010081: YEL072W
subclass of: SO_0000673
so part of: YEL072W
location: 13720..14415
location: region:13720-14415:1
so has part: feature:13720-14415:1:exon

NP_010842.1
type: Protein
SIO_000068: ncbiprotein

S000000798
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:13720-14415:1:exon

YEL071W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DLD3
locus tag: YEL071W
so part of: sequence
location: <16355..>17845
location: region:16355-17845:1
so has part: feature:16355-17845:1:exon
subclass of: SO_0000010

856638
type: Gene
SIO_000068: ncbigene

position:16355:1
position: 16355
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:17845:1
position: 17845
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:16355-17845:1:exon

YEL071W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DLD3
locus tag: YEL071W
product: D-lactate dehydrogenase
transcript id: NM_001178886.1
SIO_010081: YEL071W
subclass of: SO_0000673
so part of: YEL071W
location: <16355..>17845
location: region:16355-17845:1
so has part: feature:16355-17845:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:16355-17845:1:exon

YEL071W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DLD3
locus tag: YEL071W
EC number: 1.1.2.4
EC number: 1.1.99.40
experiment: EXISTENCE:direct assay:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:10509019]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10509019|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0071949 FAD binding [PMID:26774271]
experiment: EXISTENCE:direct assay:GO:0099615 (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity [PMID:26774271]
experiment: EXISTENCE:mutant phenotype:GO:0019249 lactate biosynthetic process [PMID:26774271]
experiment: EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:16999827]
experiment: EXISTENCE:mutant phenotype:GO:0099615 (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity [PMID:26774271]
note: 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
codon start: 1
product: D-lactate dehydrogenase
translation: MTAAHPVAQLTAEAYPKVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNLILLPNSTDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFKCDAGVVMRDAHQFLHDHDHIFPLDLPSRNNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEVVLPNGEIISNINALRKDNTGYDLKQLFIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIENFDTVQKLFVKAKSELSEILSAFEFMDRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSNKRHDDEKLTAFLKDTTDSKLISEGMMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSLQLKDLYSVSAAVTERLNAAGLIGDAPKPVVKSCGYGHVGDGNIHLNIAVREFTKQIEDLLEPFVYEYIASKKGSISAEHGIGFHKKGKLHYTRSDIEIRFMKDIKNHYDPNGILNPYKYI
SIO_010081: YEL071W
subclass of: SO_0000673
so part of: YEL071W
location: 16355..17845
location: region:16355-17845:1
so has part: feature:16355-17845:1:exon

NP_010843.1
type: Protein
SIO_000068: ncbiprotein

S000000797
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:16355-17845:1:exon

YEL070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MAN1
gene: DSF1
locus tag: YEL070W
gene synonym: MAN1
so part of: sequence
location: <19589..>21097
location: region:19589-21097:1
so has part: feature:19589-21097:1:exon
subclass of: SO_0000010

856639
type: Gene
SIO_000068: ncbigene

position:19589:1
position: 19589
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:21097:1
position: 21097
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:19589-21097:1:exon

YEL070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MAN1
gene: DSF1
locus tag: YEL070W
gene synonym: MAN1
product: mannitol dehydrogenase DSF1
transcript id: NM_001178885.1
SIO_010081: YEL070W
subclass of: SO_0000673
so part of: YEL070W
location: <19589..>21097
location: region:19589-21097:1
so has part: feature:19589-21097:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:19589-21097:1:exon

YEL070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MAN1
gene: DSF1
locus tag: YEL070W
gene synonym: MAN1
EC number: 1.1.1.67
experiment: EXISTENCE:mutant phenotype:GO:0046029 mannitol dehydrogenase activity [PMID:26996892]
note: Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication
codon start: 1
product: mannitol dehydrogenase DSF1
translation: MTKSDETTATSLNAKTLKSFESTLPIPTYPREGVKQGIVHLGVGAFHRSHLAVFMHRLMQEHHLKDWSICGVGLMKADALMRDAMKAQDCLYTLVERGIKDTNAYIVGSITAYMYAPDDPRAVIEKMANPDTHIVSLTVTENGYYHSEATNSLMTDAPEIINDLNHPEKPDTLYGYLYEALLLRYKRGLTPFTIMSCDNMPQNGVTVKTMLVAFAKLKKDEKFAAWIEDKVTSPNSMVDRVTPRCTDKERKYVADTWGIKDQCPVVAEPFIQWVLEDNFSDGRPPWELVGVQVVKDVDSYELMKLRLLNGGHSAMGYLGYLAGYTYIHEVVNDPTINKYIRVLMREEVIPLLPKVPGVDFEEYTASVLERFSNPAIQDTVARICLMGSGKMPKYVLPSIYEQLRKPDGKYKLLAVCVAGWFRYLTGVDMNGKPFEIEDPMAPTLKAAAVKGGKDPHELLNIEVLFSPEIRDNKEFVAQLTHSLETVYDKGPIAAIKEILDQV
SIO_010081: YEL070W
subclass of: SO_0000673
so part of: YEL070W
location: 19589..21097
location: region:19589-21097:1
so has part: feature:19589-21097:1:exon

NP_010844.1
type: Protein
SIO_000068: ncbiprotein

S000000796
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:19589-21097:1:exon

YEL069C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HLT1
gene: HXT13
locus tag: YEL069C
gene synonym: HLT1
so part of: sequence
location: complement(<21537..>23231)
location: region:21537-23231:-1
so has part: feature:21537-23231:-1:exon
subclass of: SO_0000010

856640
type: Gene
SIO_000068: ncbigene

position:21537:-1
position: 21537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:23231:-1
position: 23231
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:21537-23231:-1:exon

YEL069C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HLT1
gene: HXT13
locus tag: YEL069C
gene synonym: HLT1
product: hexose transporter HXT13
transcript id: NM_001178884.1
SIO_010081: YEL069C
subclass of: SO_0000673
so part of: YEL069C
location: complement(<21537..>23231)
location: region:21537-23231:-1
so has part: feature:21537-23231:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:21537-23231:-1:exon

YEL069C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HLT1
gene: HXT13
locus tag: YEL069C
gene synonym: HLT1
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]
experiment: EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0005355 glucose transmembrane transporter activity [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]
experiment: EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]
note: Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication
codon start: 1
product: hexose transporter HXT13
translation: MSSAQSSIDSDGDVRDADIHVAPPVEKEWSDGFDDNEVINGDNVEPPKRGLIGYLVIYLLCYPISFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYDNTAQWRVPLGLCFLWALIIIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIKPWKSASWVPPSRRGISSEESKTEKKDWKKFLKFSKNSD
SIO_010081: YEL069C
subclass of: SO_0000673
so part of: YEL069C
location: complement(21537..23231)
location: region:21537-23231:-1
so has part: feature:21537-23231:-1:exon

NP_010845.1
type: Protein
SIO_000068: ncbiprotein

S000000795
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:21537-23231:-1:exon

YEL068C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL068C
so part of: sequence
location: complement(<25646..>25978)
location: region:25646-25978:-1
so has part: feature:25646-25978:-1:exon
subclass of: SO_0000010

856641
type: Gene
SIO_000068: ncbigene

position:25646:-1
position: 25646
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:25978:-1
position: 25978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:25646-25978:-1:exon

YEL068C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL068C
product: uncharacterized protein
transcript id: NM_001270743.1
SIO_010081: YEL068C
subclass of: SO_0000673
so part of: YEL068C
location: complement(<25646..>25978)
location: region:25646-25978:-1
so has part: feature:25646-25978:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:25646-25978:-1:exon

YEL068C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL068C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole
codon start: 1
product: uncharacterized protein
translation: MKILALAVAFQGLALVCCTDTTDNYNNFTHNTSTFYRIADYDKRFWSVKLPPVNWTTCGNEDHPWITIHYDEIDKLVDDKLASWDKGPVPDREEFRNSILRQARCDRPHY
SIO_010081: YEL068C
subclass of: SO_0000673
so part of: YEL068C
location: complement(25646..25978)
location: region:25646-25978:-1
so has part: feature:25646-25978:-1:exon

NP_001257672.1
type: Protein
SIO_000068: ncbiprotein

S000000794
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:25646-25978:-1:exon

YEL067C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL067C
so part of: sequence
location: complement(<26189..>26776)
location: region:26189-26776:-1
so has part: feature:26189-26776:-1:exon
subclass of: SO_0000010

856643
type: Gene
SIO_000068: ncbigene

position:26189:-1
position: 26189
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:26776:-1
position: 26776
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26189-26776:-1:exon

YEL067C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL067C
product: uncharacterized protein
transcript id: NM_001178882.1
SIO_010081: YEL067C
subclass of: SO_0000673
so part of: YEL067C
location: complement(<26189..>26776)
location: region:26189-26776:-1
so has part: feature:26189-26776:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26189-26776:-1:exon

YEL067C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL067C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: uncharacterized protein
translation: MAFTTIRSLTIFSGSSFDMPTFFVLAKGGDGSGVFFISLHSSILYARFPLLNILSQHSPVYCSRRFPPDNDLITGLGNIRCGQLVKKALRRVCNVPPDHQLIASVRSIGYARVAFVFCTCTSECRDNLQSVTRTSGHQTTISQPCTDIQSTRKCSTIFVSAVMQTGTITFFWTFHFPIPLQRIVNQKQPPPQSYV
SIO_010081: YEL067C
subclass of: SO_0000673
so part of: YEL067C
location: complement(26189..26776)
location: region:26189-26776:-1
so has part: feature:26189-26776:-1:exon

NP_010847.1
type: Protein
SIO_000068: ncbiprotein

S000000793
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26189-26776:-1:exon

YEL066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HPA3
locus tag: YEL066W
so part of: sequence
location: <26721..>27206
location: region:26721-27206:1
so has part: feature:26721-27206:1:exon
subclass of: SO_0000010

856642
type: Gene
SIO_000068: ncbigene

position:26721:1
position: 26721
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:27206:1
position: 27206
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:26721-27206:1:exon

YEL066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HPA3
locus tag: YEL066W
product: D-amino-acid N-acetyltransferase
transcript id: NM_001178881.2
SIO_010081: YEL066W
subclass of: SO_0000673
so part of: YEL066W
location: <26721..>27206
location: region:26721-27206:1
so has part: feature:26721-27206:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:26721-27206:1:exon

YEL066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HPA3
locus tag: YEL066W
EC number: 2.3.1.36
EC number: 2.3.1.48
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006473 protein acetylation [PMID:23775086]
experiment: EXISTENCE:direct assay:GO:0008080 N-acetyltransferase activity [PMID:23775086]
experiment: EXISTENCE:direct assay:GO:0047812 D-amino-acid N-acetyltransferase activity [PMID:15375647]
experiment: EXISTENCE:mutant phenotype:GO:0046416 D-amino acid metabolic process [PMID:16362288]
experiment: EXISTENCE:mutant phenotype:GO:0070458 cellular detoxification of nitrogen compound [PMID:16362288|PMID:23775086]
note: D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates
codon start: 1
product: D-amino-acid N-acetyltransferase
translation: MSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY
SIO_010081: YEL066W
subclass of: SO_0000673
so part of: YEL066W
location: 26721..27206
location: region:26721-27206:1
so has part: feature:26721-27206:1:exon

NP_010848.2
type: Protein
SIO_000068: ncbiprotein

S000000792
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:26721-27206:1:exon

YEL065W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ARN3
gene: SIT1
locus tag: YEL065W
gene synonym: ARN3
so part of: sequence
location: <27657..>29543
location: region:27657-29543:1
so has part: feature:27657-29543:1:exon
subclass of: SO_0000010

856644
type: Gene
SIO_000068: ncbigene

position:27657:1
position: 27657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:29543:1
position: 29543
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:27657-29543:1:exon

YEL065W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ARN3
gene: SIT1
locus tag: YEL065W
gene synonym: ARN3
product: siderophore transporter
transcript id: NM_001178880.3
SIO_010081: YEL065W
subclass of: SO_0000673
so part of: YEL065W
location: <27657..>29543
location: region:27657-29543:1
so has part: feature:27657-29543:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:27657-29543:1:exon

YEL065W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ARN3
gene: SIT1
locus tag: YEL065W
gene synonym: ARN3
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:19469713]
experiment: EXISTENCE:direct assay:GO:0006879 cellular iron ion homeostasis [PMID:9884238]
experiment: EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:10748025]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:9884238]
experiment: EXISTENCE:mutant phenotype:GO:0015344 siderophore uptake transmembrane transporter activity [PMID:9884238]
experiment: EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:9884238]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9884238]
note: Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
codon start: 1
product: siderophore transporter
translation: MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSYIELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYSQHSLLSTVNCIKTVIAAVGQIFFARLSDIFGRFSIMIVSIIFYSMGTIIESQAVNITRFAVGGCFYQLGLTGIILILEVIASDFSNLNWRLLALFIPALPFIINTWISGNVTSAIDANWKWGIGMWAFILPLACIPLGICMLHMRYLARKHAKDRLKPEFEALNKLKWKSFCIDIAFWKLDIIGMLLITVFFGCVLVPFTLAGGLKEEWKTAHIIVPEVIGWVVVLPLYMLWEIKYSRHPLTPWDLIQDRGIFFALLIAFFINFNWYMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVIVGTILGFILIKVRRTKPFIIFGISCWIVSFGLLVHYRGDSGAHSGIIGSLCLLGFGAGSFTYVTQASIQASAKTHARMAVVTSLYLATYNIGSAFGSSVSGAVWTNILPKEISKRISDPTLAAQAYGSPFTFITTYTWGTPERIALVMSYRYVQKILCIIGLVFCFPLLGCAFMLRNHKLTDSIALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD
SIO_010081: YEL065W
subclass of: SO_0000673
so part of: YEL065W
location: 27657..29543
location: region:27657-29543:1
so has part: feature:27657-29543:1:exon

NP_010849.3
type: Protein
SIO_000068: ncbiprotein

S000000791
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:27657-29543:1:exon

YEL064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVT2
locus tag: YEL064C
so part of: sequence
location: complement(<29797..>31239)
location: region:29797-31239:-1
so has part: feature:29797-31239:-1:exon
subclass of: SO_0000010

856645
type: Gene
SIO_000068: ncbigene

position:29797:-1
position: 29797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:31239:-1
position: 31239
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:29797-31239:-1:exon

YEL064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVT2
locus tag: YEL064C
product: Avt2p
transcript id: NM_001178879.1
SIO_010081: YEL064C
subclass of: SO_0000673
so part of: YEL064C
location: complement(<29797..>31239)
location: region:29797-31239:-1
so has part: feature:29797-31239:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:29797-31239:-1:exon

YEL064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVT2
locus tag: YEL064C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11274162]
note: Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
codon start: 1
product: Avt2p
translation: MSELGEYSKLENKELRTEFELTNFPFPGTTDNDSDDGSQGQNSLNIITPDMDDTLVNDVLRENDKKSSMRMAFMNLANSILGAGIITQPFAIKNAGILGGLLSYVALGFIVDWTLRLIVINLTLAGKRTYQGTVEHVMGKKGKLLILFTNGLFAFGGCIGYCIIIGDTIPHVLRAIFSQNDGNVHFWLRRNVIIVMVTTFISFPLSMKRNIEALSKASFLAVISMIIIVLTVVIRGPMLPYDWKGHSLKLSDFFMKATIFRSLSVISFALVCHHNTSFIFFSMRNRSVAKFTRLTHISIIISVICCALMGYSGFAVFKEKTKGNVLNSFPGTDTAINIARLCFGFNMLTTFPMEIFVLRDVVGNLLHECNLIKNYDEHTQLSGKQHVVITSSLVFITMGISLTTCNLGALFELIGATTASTMAYILPPYTNLLLTSKKKSWKERLPFYLCICFGFMIMIISSTQTIIDAVNGSDGQHCQI
SIO_010081: YEL064C
subclass of: SO_0000673
so part of: YEL064C
location: complement(29797..31239)
location: region:29797-31239:-1
so has part: feature:29797-31239:-1:exon

NP_010850.1
type: Protein
SIO_000068: ncbiprotein

S000000790
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:29797-31239:-1:exon

YEL063C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAN1
locus tag: YEL063C
so part of: sequence
location: complement(<31694..>33466)
location: region:31694-33466:-1
so has part: feature:31694-33466:-1:exon
subclass of: SO_0000010

856646
type: Gene
SIO_000068: ncbigene

position:31694:-1
position: 31694
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:33466:-1
position: 33466
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:31694-33466:-1:exon

YEL063C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAN1
locus tag: YEL063C
product: arginine permease CAN1
transcript id: NM_001178878.1
SIO_010081: YEL063C
subclass of: SO_0000673
so part of: YEL063C
location: complement(<31694..>33466)
location: region:31694-33466:-1
so has part: feature:31694-33466:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:31694-33466:-1:exon

YEL063C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAN1
locus tag: YEL063C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15536122]
experiment: EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]
experiment: EXISTENCE:direct assay:GO:0032126 eisosome [PMID:29402931|PMID:15536122]
experiment: EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]
experiment: EXISTENCE:genetic interaction:GO:1903826 L-arginine transmembrane transport [PMID:23047103]
experiment: EXISTENCE:mutant phenotype:GO:0061459 L-arginine transmembrane transporter activity [PMID:10753927]
note: Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
codon start: 1
product: arginine permease CAN1
translation: MTNSKEDADIEEKHMYNEPVTTLFHDVEASQTHHRRGSIPLKDEKSKELYPLRSFPTRVNGEDTFSMEDGIGDEDEGEVQNAEVKRELKQRHIGMIALGGTIGTGLFIGLSTPLTNAGPVGALISYLFMGSLAYSVTQSLGEMATFIPVTSSFTVFSQRFLSPAFGAANGYMYWFSWAITFALELSVVGQVIQFWTYKVPLAAWISIFWVIITIMNLFPVKYYGEFEFWVASIKVLAIIGFLIYCFCMVCGAGVTGPVGFRYWRNPGAWGPGIISKDKNEGRFLGWVSSLINAAFTFQGTELVGITAGEAANPRKSVPRAIKKVVFRILTFYIGSLLFIGLLVPYNDPKLTQSTSYVSTSPFIIAIENSGTKVLPHIFNAVILTTIISAANSNIYVGSRILFGLSKNKLAPKFLSRTTKGGVPYIAVFVTAAFGALAYMETSTGGDKVFEWLLNITGVAGFFAWLFISISHIRFMQALKYRGISRDELPFKAKLMPGLAYYAATFMTIIIIIQGFTAFAPKFNGVSFAAAYISIFLFLAVWILFQCIFRCRFIWKIGDVDIDSDRRDIEAIVWEDHEPKTFWDKFWNVVA
SIO_010081: YEL063C
subclass of: SO_0000673
so part of: YEL063C
location: complement(31694..33466)
location: region:31694-33466:-1
so has part: feature:31694-33466:-1:exon

NP_010851.1
type: Protein
SIO_000068: ncbiprotein

S000000789
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:31694-33466:-1:exon

YEL062W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NPR2
locus tag: YEL062W
so part of: sequence
location: <34407..>36254
location: region:34407-36254:1
so has part: feature:34407-36254:1:exon
subclass of: SO_0000010

856647
type: Gene
SIO_000068: ncbigene

position:34407:1
position: 34407
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:36254:1
position: 36254
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:34407-36254:1:exon

YEL062W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NPR2
locus tag: YEL062W
product: nitrogen permease regulating protein NPR2
transcript id: NM_001178877.3
SIO_010081: YEL062W
subclass of: SO_0000673
so part of: YEL062W
location: <34407..>36254
location: region:34407-36254:1
so has part: feature:34407-36254:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:34407-36254:1:exon

YEL062W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NPR2
locus tag: YEL062W
experiment: EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]
experiment: EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]
experiment: EXISTENCE:genetic interaction:GO:0010508 positive regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719|PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:12869630]
experiment: EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:7867803]
experiment: EXISTENCE:mutant phenotype:GO:0015840 urea transport [PMID:7867803]
experiment: EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:19521502|PMID:23716719|PMID:25046117]
experiment: EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]
note: Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2
codon start: 1
product: nitrogen permease regulating protein NPR2
translation: MLSYFQGFVPIHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNTFKNYIIPKPILCHKLITFKYGTYRIVCYPVTINSPIYARNFFSFNFVFVFPYDCETSPYEPAITRLGKMFKVLEEQNQLLSKSERDPVFFDLKVLENSTTTPSTAGPSSTPNPSSNTTPTHPTSEKDTKDMRSSRYSDLIKDLGLPQSAFSIQDLLMRIFQDLNNYSECLIPIDEGNAVDIKIFPLLRPPTTCVSLEDVPLSSVNLKKIIDVNWDPTMMSIVPYIDGLNSIAKISKLSNSDPGLVIECIRHLIYYKCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDCQSYVTFPEVSKISNLPLNKSLGSGDQDSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSLNSSFSSIYKDWRQSQTSCSSSNIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESKYMILKENNIDIRRFITFGLEKRIIYRCYSFPVMINAGSREPKEMTPIITKDLVNNDKLLEKRNHNHLLSATGSRNTAQSGNLKPERPSKVSFEMQRVSSLATGKSTMPKLSDEEEGILEESIRNAETFDKICVLLSKPKLEVESYLNELGEFKVINS
SIO_010081: YEL062W
subclass of: SO_0000673
so part of: YEL062W
location: 34407..36254
location: region:34407-36254:1
so has part: feature:34407-36254:1:exon

NP_010852.4
type: Protein
SIO_000068: ncbiprotein

S000000788
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:34407-36254:1:exon

YEL061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KSL2
alternative label: SDS15
gene: CIN8
locus tag: YEL061C
gene synonym: KSL2; SDS15
so part of: sequence
location: complement(<36535..>39537)
location: region:36535-39537:-1
so has part: feature:36535-39537:-1:exon
subclass of: SO_0000010

856648
type: Gene
SIO_000068: ncbigene

position:36535:-1
position: 36535
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:39537:-1
position: 39537
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:36535-39537:-1:exon

YEL061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KSL2
alternative label: SDS15
gene: CIN8
locus tag: YEL061C
gene synonym: KSL2; SDS15
product: kinesin motor protein CIN8
transcript id: NM_001178876.1
SIO_010081: YEL061C
subclass of: SO_0000673
so part of: YEL061C
location: complement(<36535..>39537)
location: region:36535-39537:-1
so has part: feature:36535-39537:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:36535-39537:-1:exon

YEL061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KSL2
alternative label: SDS15
gene: CIN8
locus tag: YEL061C
gene synonym: KSL2; SDS15
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005828 kinetochore microtubule [PMID:19041752]
experiment: EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347|PMID:1618897]
experiment: EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:21350123]
experiment: EXISTENCE:direct assay:GO:0008574 plus-end-directed microtubule motor activity [PMID:21350123]
experiment: EXISTENCE:direct assay:GO:0033047 regulation of mitotic sister chromatid segregation [PMID:31253793]
experiment: EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:7860634]
experiment: EXISTENCE:genetic interaction:GO:0000073 initial mitotic spindle pole body separation [PMID:1618897|PMID:1618910]
experiment: EXISTENCE:genetic interaction:GO:0003777 microtubule motor activity [PMID:1618910]
experiment: EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:23851487|PMID:9813090]
experiment: EXISTENCE:mutant phenotype:GO:0000073 initial mitotic spindle pole body separation [PMID:1618897]
experiment: EXISTENCE:mutant phenotype:GO:0000235 astral microtubule [PMID:19041752]
experiment: EXISTENCE:mutant phenotype:GO:0007019 microtubule depolymerization [PMID:19041752]
experiment: EXISTENCE:mutant phenotype:GO:0008569 minus-end-directed microtubule motor activity [PMID:27216310]
experiment: EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:31964755]
experiment: EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:23851487|PMID:9813090]
note: Bipolar kinesin motor protein; switches from minus- to plus-end-directed motility in vitro depending on conditions; involved in mitotic spindle assembly and chromosome segregation
codon start: 1
product: kinesin motor protein CIN8
translation: MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRGRNEREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFDTLELQQNDYVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSHTIFTITLYKKHQDELFRISKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLGRVINALVDKSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSKEGIYMSQDHYKNLNSDLESYKNEVQECKREIESLTSKNALLVKDKLKSKETIQSQNCQIESLKTTIDHLRAQLDKQHKTEIEISDFNNKLQKLTEVMQMALHDYKKRELDLNQKFEMHITKEIKKLKSTLFLQLNTMQQESILQETNIQPNLDMIKNEVLTLMRTMQEKAELMYKDCVKKILNESPKFFNVVIEKIDIIRVDFQKFYKNIAENLSDISEENNNMKQYLKNHFFKNNHQELLNRHVDSTYENIEKRTNEFVENFKKVLNDHLDENKKLIMQNLTTATSAVIDQEMDLFEPKRVKWENSFDLINDCDSMNNEFYNSMAATLSQIKSTVDTSSNSMNESISVMKGQVEESENAISLLKNNTKFNDQFEQLINKHNMLKDNIKNSITSTHSHITNVDDIYNTIENIMKNYGNKENATKDEMIENILKEIPNLSKKMPLRLSNINSNSVQSVISPKKHAIEDENKSSENVDNEGSRKMLKIE
SIO_010081: YEL061C
subclass of: SO_0000673
so part of: YEL061C
location: complement(36535..39537)
location: region:36535-39537:-1
so has part: feature:36535-39537:-1:exon

NP_010853.2
type: Protein
SIO_000068: ncbiprotein

S000000787
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:36535-39537:-1:exon

YEL060C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CVT1
gene: PRB1
locus tag: YEL060C
gene synonym: CVT1
so part of: sequence
location: complement(<40046..>41953)
location: region:40046-41953:-1
so has part: feature:40046-41953:-1:exon
subclass of: SO_0000010

856649
type: Gene
SIO_000068: ncbigene

position:40046:-1
position: 40046
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:41953:-1
position: 41953
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:40046-41953:-1:exon

YEL060C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CVT1
gene: PRB1
locus tag: YEL060C
gene synonym: CVT1
product: proteinase B
transcript id: NM_001178875.1
SIO_010081: YEL060C
subclass of: SO_0000673
so part of: YEL060C
location: complement(<40046..>41953)
location: region:40046-41953:-1
so has part: feature:40046-41953:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:40046-41953:-1:exon

YEL060C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CVT1
gene: PRB1
locus tag: YEL060C
gene synonym: CVT1
EC number: 3.4.21.48
experiment: EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]
experiment: EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:377296|PMID:385314]
experiment: EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:2674123|PMID:385314]
experiment: EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:2674123]
experiment: EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:2674123]
note: Vacuolar proteinase B yscB with H3 N-terminal endopeptidase activity; serine protease of subtilisin family; involved in protein degradation in vacuole; required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; PRB1 has a paralog, YSP3, that arose from the whole genome duplication
codon start: 1
product: proteinase B
translation: MKLENTLFTLGALGSISAALVIPNLENAADHHELINKEDHHERPRKVEFTKDDDEEPSDSEDKEHGKFHKKGRKGQDKESPEFNGKRASGSHGSAHEGGKGMKPKHESSNDDDNDDKKKKPHHKGGCHENKVEEKKMKGKKVKGKKHHEKTLEKGRHHNRLAPLVSTAQFNPDAISKIIPNRYIIVFKRGAPQEEIDFHKENVQQAQLQSVENLSAEDAFFISTKDTSLSTSEAGGIQDSFNIDNLFSGYIGYFTQEIVDLIRQNPLVDFVERDSIVEATEFDTQNSAPWGLARISHRERLNLGSFNKYLYDDDAGRGVTSYVIDTGVNINHKDFEKRAIWGKTIPLNDEDLDGNGHGTHCAGTIASKHYGVAKNANVVAVKVLRSNGSGTMSDVVKGVEYAAKAHQKEAQEKKKGFKGSTANMSLGGGKSPALDLAVNAAVEVGIHFAVAAGNENQDACNTSPASADKAITVGASTLSDDRAYFSNWGKCVDVFAPGLNILSTYIGSDDATATLSGTSMASPHVAGLLTYFLSLQPGSDSEFFELGQDSLTPQQLKKKLIHYSTKDILFDIPEDTPNVLIYNGGGQDLSAFWNDTKKSHSSGFKQELNMDEFIGSKTDLIFDQVRDILDKLNII
SIO_010081: YEL060C
subclass of: SO_0000673
so part of: YEL060C
location: complement(40046..41953)
location: region:40046-41953:-1
so has part: feature:40046-41953:-1:exon

NP_010854.1
type: Protein
SIO_000068: ncbiprotein

S000000786
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:40046-41953:-1:exon

YEL059C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SOM1
locus tag: YEL059C-A
so part of: sequence
location: complement(<42400..>42624)
location: region:42400-42624:-1
so has part: feature:42400-42624:-1:exon
subclass of: SO_0000010

856650
type: Gene
SIO_000068: ncbigene

position:42400:-1
position: 42400
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42624:-1
position: 42624
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42400-42624:-1:exon

YEL059C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SOM1
locus tag: YEL059C-A
product: Som1p
transcript id: NM_001180854.3
SIO_010081: YEL059C-A
subclass of: SO_0000673
so part of: YEL059C-A
location: complement(<42400..>42624)
location: region:42400-42624:-1
so has part: feature:42400-42624:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42400-42624:-1:exon

YEL059C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SOM1
locus tag: YEL059C-A
experiment: EXISTENCE:curator inference:GO:0004175 endopeptidase activity [PMID:10821182]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9604886]
experiment: EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]
experiment: EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:10821182]
note: Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
codon start: 1
product: Som1p
translation: MAPPTTIRTRDQALAPLATLDSQTNCRLKELVQWECQFKGAEYVCSPFKRLFEHCIAPDKSATNYEVTDTYTNS
SIO_010081: YEL059C-A
subclass of: SO_0000673
so part of: YEL059C-A
location: complement(42400..42624)
location: region:42400-42624:-1
so has part: feature:42400-42624:-1:exon

NP_058154.3
type: Protein
SIO_000068: ncbiprotein

S000002954
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42400-42624:-1:exon

YEL059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HHY1
locus tag: YEL059W
so part of: sequence
location: <42652..>42960
location: region:42652-42960:1
so has part: feature:42652-42960:1:exon
subclass of: SO_0000010

856651
type: Gene
SIO_000068: ncbigene

position:42652:1
position: 42652
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:42960:1
position: 42960
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:42652-42960:1:exon

YEL059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HHY1
locus tag: YEL059W
product: Hhy1p
transcript id: NM_001395033.1
SIO_010081: YEL059W
subclass of: SO_0000673
so part of: YEL059W
location: <42652..>42960
location: region:42652-42960:1
so has part: feature:42652-42960:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:42652-42960:1:exon

YEL059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HHY1
locus tag: YEL059W
note: hypothetical protein; null mutant is sensitive to heat, pH disturbances, ionic stress, and various chemicals; hypersensitivity to hygromycin B indicative of defects in vacuolar trafficking
codon start: 1
product: Hhy1p
translation: MSLSFLLFSPFLPPCFSSISICLSVLSTVSFFFAFTIPHYVLRCGSVDEWHIHSSAEDFRTQRCVCAVKLSASLLGCLLACASWSLLLEVSRIKWHVGTAYS
SIO_010081: YEL059W
subclass of: SO_0000673
so part of: YEL059W
location: 42652..42960
location: region:42652-42960:1
so has part: feature:42652-42960:1:exon

NP_001381963.1
type: Protein
SIO_000068: ncbiprotein

S000000785
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:42652-42960:1:exon

YEL058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AGM1
gene: PCM1
locus tag: YEL058W
gene synonym: AGM1
so part of: sequence
location: <43252..>44925
location: region:43252-44925:1
so has part: feature:43252-44925:1:exon
subclass of: SO_0000010

856652
type: Gene
SIO_000068: ncbigene

position:43252:1
position: 43252
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:44925:1
position: 44925
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:43252-44925:1:exon

YEL058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AGM1
gene: PCM1
locus tag: YEL058W
gene synonym: AGM1
product: phosphoacetylglucosamine mutase PCM1
transcript id: NM_001178873.1
SIO_010081: YEL058W
subclass of: SO_0000673
so part of: YEL058W
location: <43252..>44925
location: region:43252-44925:1
so has part: feature:43252-44925:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:43252-44925:1:exon

YEL058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AGM1
gene: PCM1
locus tag: YEL058W
gene synonym: AGM1
EC number: 5.4.2.3
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004610 phosphoacetylglucosamine mutase activity [PMID:8174553]
experiment: EXISTENCE:mutant phenotype:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:8174553]
note: Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
codon start: 1
product: phosphoacetylglucosamine mutase PCM1
translation: MKVDYEQLCKLYDDTCRTKNVQFSYGTAGFRTLAKNLDTVMFSTGILAVLRSLKLQGQYVGVMITASHNPYQDNGVKIVEPDGSMLLATWEPYAMQLANAASFATNFEEFRVELAKLIEHEKIDLNTTVVPHIVVGRDSRESSPYLLRCLTSSMASVFHAQVLDLGCVTTPQLHYITDLSNRRKLEGDTAPVATEQDYYSFFIGAFNELFATYQLEKRLSVPKLFIDTANGIGGPQLKKLLASEDWDVPAEQVEVINDRSDVPELLNFECGADYVKTNQRLPKGLSPSSFDSLYCSFDGDADRVVFYYVDSGSKFHLLDGDKISTLFAKFLSKQLELAHLEHSLKIGVVQTAYANGSSTAYIKNTLHCPVSCTKTGVKHLHHEAATQYDIGIYFEANGHGTIIFSEKFHRTIKSELSKSKLNGDTLALRTLKCFSELINQTVGDAISDMLAVLATLAILKMSPMDWDEEYTDLPNKLVKCIVPDRSIFQTTDQERKLLNPVGLQDKIDLVVAKYPMGRSFVRASGTEDAVRVYAECKDSSKLGQFCDEVVEHVKASA
SIO_010081: YEL058W
subclass of: SO_0000673
so part of: YEL058W
location: 43252..44925
location: region:43252-44925:1
so has part: feature:43252-44925:1:exon

NP_010856.1
type: Protein
SIO_000068: ncbiprotein

S000000784
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:43252-44925:1:exon

YEL057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SDD1
locus tag: YEL057C
so part of: sequence
location: complement(<45020..>45721)
location: region:45020-45721:-1
so has part: feature:45020-45721:-1:exon
subclass of: SO_0000010

856653
type: Gene
SIO_000068: ncbigene

position:45020:-1
position: 45020
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:45721:-1
position: 45721
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:45020-45721:-1:exon

YEL057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SDD1
locus tag: YEL057C
product: Sdd1p
transcript id: NM_001178872.1
SIO_010081: YEL057C
subclass of: SO_0000673
so part of: YEL057C
location: complement(<45020..>45721)
location: region:45020-45721:-1
so has part: feature:45020-45721:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:45020-45721:-1:exon

YEL057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SDD1
locus tag: YEL057C
note: hypothetical protein; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation
codon start: 1
product: Sdd1p
translation: MANDGIQRNDNRKGFKTVQFSAYSKEIDVIMKKISFLERNITQQLDTLPHFPKTLPPNHKDCVSRKHRARRGWSSQLKNLLGIYSKEEIFTLDNLAATLHDQVLKLQATLFPNAILKQVHLDNANIENKRILKEITYKYLSNENCKEENKFGTFIVKRIFFGDLSLGVSVLINRIAFESATSSIMVVRSSFIESDFFYEDYLIFDCRAKRRKKLKRKILFISTTMNFNYQTKV
SIO_010081: YEL057C
subclass of: SO_0000673
so part of: YEL057C
location: complement(45020..45721)
location: region:45020-45721:-1
so has part: feature:45020-45721:-1:exon

NP_010857.1
type: Protein
SIO_000068: ncbiprotein

S000000783
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:45020-45721:-1:exon

YEL056W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HAT2
locus tag: YEL056W
so part of: sequence
location: <47168..>48373
location: region:47168-48373:1
so has part: feature:47168-48373:1:exon
subclass of: SO_0000010

856654
type: Gene
SIO_000068: ncbigene

position:47168:1
position: 47168
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:48373:1
position: 48373
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:47168-48373:1:exon

YEL056W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HAT2
locus tag: YEL056W
product: Hat2p
transcript id: NM_001178871.3
SIO_010081: YEL056W
subclass of: SO_0000673
so part of: YEL056W
location: <47168..>48373
location: region:47168-48373:1
so has part: feature:47168-48373:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:47168-48373:1:exon

YEL056W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HAT2
locus tag: YEL056W
experiment: EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:8858151|PMID:9575221]
experiment: EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:8858151]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14761951|PMID:9575221]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8858151|PMID:9575221]
experiment: EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:8858151]
experiment: EXISTENCE:direct assay:GO:0042393 histone binding [PMID:8858151]
experiment: EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:10982821]
experiment: EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:8858151|PMID:9575221]
experiment: EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:8858151]
note: Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
codon start: 1
product: Hat2p
translation: MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPTPVQELDGGFIKQELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDIIS
SIO_010081: YEL056W
subclass of: SO_0000673
so part of: YEL056W
location: 47168..48373
location: region:47168-48373:1
so has part: feature:47168-48373:1:exon

NP_010858.3
type: Protein
SIO_000068: ncbiprotein

S000000782
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:47168-48373:1:exon

YEL055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: POL5
locus tag: YEL055C
so part of: sequence
location: complement(<48471..>51539)
location: region:48471-51539:-1
so has part: feature:48471-51539:-1:exon
subclass of: SO_0000010

856655
type: Gene
SIO_000068: ncbigene

position:48471:-1
position: 48471
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:51539:-1
position: 51539
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:48471-51539:-1:exon

YEL055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: POL5
locus tag: YEL055C
product: DNA-directed DNA polymerase
transcript id: NM_001178870.1
SIO_010081: YEL055C
subclass of: SO_0000673
so part of: YEL055C
location: complement(<48471..>51539)
location: region:48471-51539:-1
so has part: feature:48471-51539:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:48471-51539:-1:exon

YEL055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: POL5
locus tag: YEL055C
EC number: 2.7.7.7
experiment: EXISTENCE:direct assay:GO:0000027 ribosomal large subunit assembly [PMID:31745560]
experiment: EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:12093911]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12093911|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:31745560]
experiment: EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:31745560|PMID:31413149]
experiment: EXISTENCE:direct assay:GO:0090070 positive regulation of ribosome biogenesis [PMID:31745560]
experiment: EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:12093911]
experiment: EXISTENCE:mutant phenotype:GO:0030685 nucleolar preribosome [PMID:31413149]
experiment: EXISTENCE:mutant phenotype:GO:0090070 positive regulation of ribosome biogenesis [PMID:31413149]
note: Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication
codon start: 1
product: DNA-directed DNA polymerase
translation: MTGKVNRDLFFKLASDLREERLHAAVALIKDLSALDLPDDAEEWSYVLNRLIKGLSSDRNSARLGFSLCLTEVINLAVNMPPGQRPKGLESTNEFLSTLSTILNVNVNEGTKKSMKGKDERGILFGKLFGLKSLLNEPLFSEIFVKDLEKGNTEFFIRFTEQLIDLALKKNWIKEPCFFTLFQTMKMLLPFMDESSAEKILLIYDKYDLTLTNEGLSTYLLLKYEGDESLIPSVLDLKNPGWKDNDPLARGNLPLLTKVLRNSSVIPDANGGLKETKKQKNTNWNPRLHFVWSVLLPLFGNGKLENTSHISKKRKKTNNKKVQNSIQFPEFWKMAVDESFFNEKASSERKYLGFLIIDAAFKAVPGSYIGFCFSQNVMRTLINQSIDSQRVLNKISQLTLDSIVKACEEDSANRLVPCLNAMLFGPHGSINFDKLTKSGTVSKLIAIKELPSTVLAQLLDVFFLQLQDKKGVLSHTLFALDSILHIVRAHKVEINDMDIMKPVLRPIVYMAFFKHTSDDLKLEQLHELAKERLYSILGELTINKEIRCKDPEINSWQYLTLKLILDIENSHVGDLINPLDENLENIKNEAISCLSKVCRSRTAQSWGLSTLLSMCLVQLYAGDTDSISVIEELCEFSKHENNSMVGITEILLSLLAQKKALLRKLSLIIWQQFIEEVGLEELQILLDILKARENKQGFAQLFEGEEEFEEIKEENDASEDESKTGSESESESESDSDDADEKDEEDEANEDILNIDKEATSALVKALNLPDNIVNDKGEVDLDQLEGLSDDGGDDEDEESMDDEKMMELDDQLSEIFKRRKEALSSISTGNQRKFEVKQSRENVISFKHRVVDMLAVYVKYCEKLTLANKSEHSNNLGGSLSKLVYFIIPMLKCVNETLDRPLADKISKLLKGKIFKIKVTAFKDMNKDIELMDLLKKTHKLMLTSKPGQHAAVFYSMCSTSSLFLSKLYVEIGGNDKLDELIDLYTATTKEWMQKGKCGPNIFIDFINWLSSKKQTVMDKE
SIO_010081: YEL055C
subclass of: SO_0000673
so part of: YEL055C
location: complement(48471..51539)
location: region:48471-51539:-1
so has part: feature:48471-51539:-1:exon

NP_010859.1
type: Protein
SIO_000068: ncbiprotein

S000000781
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:48471-51539:-1:exon

YNCE0001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR80
locus tag: YNCE0001C
so part of: sequence
location: complement(52150..52320)
location: region:52150-52320:-1
so has part: feature:52150-52320:-1:exon
subclass of: SO_0000578

9164883
type: Gene
SIO_000068: ncbigene

position:52150:-1
position: 52150
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:52320:-1
position: 52320
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52150-52320:-1:exon

YNCE0001C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR80
locus tag: YNCE0001C
product: SNR80
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:15306656]
experiment: EXISTENCE:mutant phenotype:GO:0030559 rRNA pseudouridylation guide activity [PMID:15306656|PMID:15923376]
experiment: EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:15306656|PMID:15923376]
experiment: EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:15923376]
note: H/ACA box small nucleolar RNA (snoRNA); guides pseudouridylation of large subunit (LSU) rRNA at position U776 and small subunit (SSU) rRNA at position U759
transcript id: NR_132163.1
SIO_010081: YNCE0001C
subclass of: SO_0000673
so part of: YNCE0001C
location: complement(52150..52320)
location: region:52150-52320:-1
so has part: feature:52150-52320:-1:exon

S000081374
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52150-52320:-1:exon

YEL054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL12A
locus tag: YEL054C
so part of: sequence
location: complement(<52721..>53218)
location: region:52721-53218:-1
so has part: feature:52721-53218:-1:exon
subclass of: SO_0000010

856656
type: Gene
SIO_000068: ncbigene

position:52721:-1
position: 52721
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:53218:-1
position: 53218
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:52721-53218:-1:exon

YEL054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL12A
locus tag: YEL054C
product: ribosomal 60S subunit protein L12A
transcript id: NM_001178869.1
SIO_010081: YEL054C
subclass of: SO_0000673
so part of: YEL054C
location: complement(<52721..>53218)
location: region:52721-53218:-1
so has part: feature:52721-53218:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:52721-53218:-1:exon

YEL054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL12A
locus tag: YEL054C
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
experiment: EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9822666]
note: Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L12A
translation: MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGEDIAKATKEFKGIKVTVQLKIQNRQAAASVVPSASSLVITALKEPPRDRKKDKNVKHSGNIQLDEIIEIARQMRDKSFGRTLASVTKEILGTAQSVGCRVDFKNPHDIIEGINAGEIEIPEN
SIO_010081: YEL054C
subclass of: SO_0000673
so part of: YEL054C
location: complement(52721..53218)
location: region:52721-53218:-1
so has part: feature:52721-53218:-1:exon

NP_010860.1
type: Protein
SIO_000068: ncbiprotein

S000000780
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:52721-53218:-1:exon

YEL053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NAA35
gene: MAK10
locus tag: YEL053C
gene synonym: NAA35
so part of: sequence
location: complement(<53901..>56102)
location: region:53901-56102:-1
so has part: feature:53901-56102:-1:exon
subclass of: SO_0000010

856657
type: Gene
SIO_000068: ncbigene

position:53901:-1
position: 53901
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:56102:-1
position: 56102
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:53901-56102:-1:exon

YEL053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NAA35
gene: MAK10
locus tag: YEL053C
gene synonym: NAA35
product: Mak10p
transcript id: NM_001178868.3
SIO_010081: YEL053C
subclass of: SO_0000673
so part of: YEL053C
location: complement(<53901..>56102)
location: region:53901-56102:-1
so has part: feature:53901-56102:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:53901-56102:-1:exon

YEL053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NAA35
gene: MAK10
locus tag: YEL053C
gene synonym: NAA35
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031417 NatC complex [PMID:10504710]
experiment: EXISTENCE:mutant phenotype:GO:0004596 peptide alpha-N-acetyltransferase activity [PMID:11274203]
experiment: EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:11274203]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]
note: Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele
codon start: 1
product: Mak10p
translation: MEVDSILGSLSITDDFDQLVDVTSLFDELCSKLKPEAIVKDPRFDLFEGTHSLEVNNSKLDSSLIELTAEEIEFDVNVAYDPPLASVAAIADRLLRCVISWLNDYQTLPTTVLSCRYTESLLSSLVKGTTAGSSWCTGNILYDKVLGSCILGVCYLTKFVQKLLSAGIVFEEEDLNFNNMGFNTFDNLPGQDVVINSLTESLQILEAYSDDSLHLTMLKHILKIIICLVHLEDHLTDYSTKTSHLDELIENANSVNGIFPQLQLSPPKGAFSTYIQKHRSNQFPPRKITKLPTDYSGFITLANDVKTILLVDKAESALETYQFAKFFNKLEQRHVIARILFPLFFIRDDRTVLGKFSYTQFYLLHVKEFSAQTPSEFESSIGNELIQESSNMLLEWYQNCSQNTCRYRQGFNRQLILWDSLQAQFESVNSQVYCSWTYFMKLSSMIEFSLKGFDLDIYKPFEAYSMFWYVYYLSHHLETFLKDSQNDIESNINAIHSMNKKLKKLKAGEKKDQLRLKYRFAMDNEMEQLQATKQFLNYLLKEINITKSLCLIEVFQFAILKSFGLIDNKNSTPSKFSNERLIHNLRFKPFNSIGVPELPEYEVFQQTLKDFVIEEKGAAFDIKLERATNFIETEVRNVVSSIDEIMQGIKGGDNNGVLVTGTRLVQELSLEYYCKLKHTSKALSVNSKVIVNTLKKNIKNKDSHEYKVELVHTTEGWNYFPIQTLRIKQDRYK
SIO_010081: YEL053C
subclass of: SO_0000673
so part of: YEL053C
location: complement(53901..56102)
location: region:53901-56102:-1
so has part: feature:53901-56102:-1:exon

NP_010861.3
type: Protein
SIO_000068: ncbiprotein

S000000779
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:53901-56102:-1:exon

YEL052W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AFG1
locus tag: YEL052W
so part of: sequence
location: <56571..>58100
location: region:56571-58100:1
so has part: feature:56571-58100:1:exon
subclass of: SO_0000010

856658
type: Gene
SIO_000068: ncbigene

position:56571:1
position: 56571
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:58100:1
position: 58100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:56571-58100:1:exon

YEL052W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AFG1
locus tag: YEL052W
product: Afg1p
transcript id: NM_001178867.1
SIO_010081: YEL052W
subclass of: SO_0000673
so part of: YEL052W
location: <56571..>58100
location: region:56571-58100:1
so has part: feature:56571-58100:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:56571-58100:1:exon

YEL052W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AFG1
locus tag: YEL052W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:17430883]
experiment: EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:17430883]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17430883]
note: Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
codon start: 1
product: Afg1p
translation: MIALKPNAVRTFRQVQHCSFRICRYQSTKSNKCLTPLQEYDRLVKLGKLRDDTYQRGIISSLGDLYDSLVKYVPPVVKTPNAVDQVGGWLNGLKSVFSRGKPKNIGAYVDVSKIGNSIPRGVYLYGDVGCGKTMLMDLFYTTIPNHLTKKRIHFHQFMQYVHKRSHEIVREQNLKELGDAKGKEIDTVPFLAAEIANNSHVLCFDEFQVTDVADAMILRRLMTALLSDDYGVVLFATSNRHPDELYINGVQRQSFIPCIELIKHRTKVIFLNSPTDYRKIPRPVSSVYYFPSDTSIKYASKECKTRRETHIKEWYNYFAQASHTDDSTDSHTVHKTFYDYPLTIWGREFKVPKCTPPRVAQFTFKQLCGEPLAAGDYLTLAKNFEAFIVTDIPYLSIYVRDEVRRFITFLDAVYDSGGKLATTGAADFSSLFVEPEQILNDFELRPTTKEPDSVDTGMVDEMVEKHGFSKEIAKKSQMFALDEERFAFARALSRLSQMSSTDWVTKPTY
SIO_010081: YEL052W
subclass of: SO_0000673
so part of: YEL052W
location: 56571..58100
location: region:56571-58100:1
so has part: feature:56571-58100:1:exon

NP_010862.1
type: Protein
SIO_000068: ncbiprotein

S000000778
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:56571-58100:1:exon

YEL051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VMA8
locus tag: YEL051W
so part of: sequence
location: <58378..>59148
location: region:58378-59148:1
so has part: feature:58378-59148:1:exon
subclass of: SO_0000010

856659
type: Gene
SIO_000068: ncbigene

position:58378:1
position: 58378
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:59148:1
position: 59148
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:58378-59148:1:exon

YEL051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VMA8
locus tag: YEL051W
product: H(+)-transporting V1 sector ATPase subunit D
transcript id: NM_001178866.1
SIO_010081: YEL051W
subclass of: SO_0000673
so part of: YEL051W
location: <58378..>59148
location: region:58378-59148:1
so has part: feature:58378-59148:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:58378-59148:1:exon

YEL051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VMA8
locus tag: YEL051W
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:23836928]
experiment: EXISTENCE:direct assay:GO:0016471 vacuolar proton-transporting V-type ATPase complex [PMID:10801866]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:29519938]
experiment: EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:10801866]
note: Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits
codon start: 1
product: H(+)-transporting V1 sector ATPase subunit D
translation: MSGNREQVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRDITKRIDDAKQKMGRVMQTAAFSLAEVSYATGENIGYQVQESVSTARFKVRARQENVSGVYLSQFESYIDPEINDFRLTGLGRGGQQVQRAKEIYSRAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFYRLKKVQEKKQNETAKLDAEMKLKRDRAEQDASEVAADEEPQGETLVADQEDDVIF
SIO_010081: YEL051W
subclass of: SO_0000673
so part of: YEL051W
location: 58378..59148
location: region:58378-59148:1
so has part: feature:58378-59148:1:exon

NP_010863.1
type: Protein
SIO_000068: ncbiprotein

S000000777
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:58378-59148:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS507; Autonomously Replicating Sequence
so part of: sequence
location: 59338..59477
location: region:59338-59477:1
so has part: feature:59338-59477:1:region

S000077380
type: SGD
SIO_000068: sgd

position:59338:1
position: 59338
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:59477:1
position: 59477
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:59338-59477:1:region

YEL050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: uL2m
gene: RML2
locus tag: YEL050C
gene synonym: uL2m
so part of: sequence
location: complement(<59670..>60851)
location: region:59670-60851:-1
so has part: feature:59670-60851:-1:exon
subclass of: SO_0000010

856660
type: Gene
SIO_000068: ncbigene

position:59670:-1
position: 59670
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:60851:-1
position: 60851
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:59670-60851:-1:exon

YEL050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: uL2m
gene: RML2
locus tag: YEL050C
gene synonym: uL2m
product: mitochondrial 54S ribosomal protein RML2
transcript id: NM_001178865.3
SIO_010081: YEL050C
subclass of: SO_0000673
so part of: YEL050C
location: complement(<59670..>60851)
location: region:59670-60851:-1
so has part: feature:59670-60851:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:59670-60851:-1:exon

YEL050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: uL2m
gene: RML2
locus tag: YEL050C
gene synonym: uL2m
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9445368]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9445368]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9079633]
note: Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor
codon start: 1
product: mitochondrial 54S ribosomal protein RML2
translation: MLVLGSLRSALSCSSTASLISKRNPCYPYGILCRTLSQSVKLWQENTSKDDSSLNITPRLLKIIPNDTDIVTLEKQDELIKRRRKLSKEVTQMKRLKPVSPGLRWYRSPIYPYLYKGRPVRALTVVRKKHGGRNNSGKITVRHQGGGHRNRTRLIDFNRWEGGAQTVQRIEYDPGRSSHIALLKHNTTGELSYIIACDGLRPGDVVESFRRGIPQTLLNEMGGKVDPAILSVKTTQRGNCLPISMIPIGTIIHNVGITPVGPGKFCRSAGTYARVLAKLPEKKKAIVRLQSGEHRYVSLEAVATIGVVSNIDHQNRSLGKAGRSRWLGIRPTVRGVAMNKCDHPHGGGRGKSKSNKLSMSPWGQLAKGYKTRRGKNQNRMKVKDRPRGKDARL
SIO_010081: YEL050C
subclass of: SO_0000673
so part of: YEL050C
location: complement(59670..60851)
location: region:59670-60851:-1
so has part: feature:59670-60851:-1:exon

NP_010864.3
type: Protein
SIO_000068: ncbiprotein

S000000776
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:59670-60851:-1:exon

YNCE0002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR67
locus tag: YNCE0002W
so part of: sequence
location: 61352..61433
location: region:61352-61433:1
so has part: feature:61352-61433:1:exon
subclass of: SO_0000578

9164880
type: Gene
SIO_000068: ncbigene

position:61352:1
position: 61352
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:61433:1
position: 61433
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61352-61433:1:exon

YNCE0002W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR67
locus tag: YNCE0002W
product: SNR67
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31804585]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at positions G2619 and U2724
transcript id: NR_132164.1
SIO_010081: YNCE0002W
subclass of: SO_0000673
so part of: YNCE0002W
location: 61352..61433
location: region:61352-61433:1
so has part: feature:61352-61433:1:exon

S000006458
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:61352-61433:1:exon

YNCE0003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR53
locus tag: YNCE0003W
so part of: sequence
location: 61699..61789
location: region:61699-61789:1
so has part: feature:61699-61789:1:exon
subclass of: SO_0000578

9164881
type: Gene
SIO_000068: ncbigene

position:61699:1
position: 61699
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:61789:1
position: 61789
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61699-61789:1:exon

YNCE0003W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR53
locus tag: YNCE0003W
product: SNR53
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of small subunit (SSU) rRNA at position A796
transcript id: NR_132165.1
SIO_010081: YNCE0003W
subclass of: SO_0000673
so part of: YNCE0003W
location: 61699..61789
location: region:61699-61789:1
so has part: feature:61699-61789:1:exon

S000006444
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:61699-61789:1:exon

YNCE0004C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0004C
so part of: sequence
location: complement(61890..61960)
location: region:61890-61960:-1
so has part: feature:61890-61960:-1:exon
subclass of: SO_0000663

856661
type: Gene
SIO_000068: ncbigene

position:61890:-1
position: 61890
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:61960:-1
position: 61960
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:61890-61960:-1:exon

YNCE0004C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0004C
product: tRNA-Gly
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0004C
subclass of: SO_0000673
so part of: YNCE0004C
location: complement(61890..61960)
location: region:61890-61960:-1
so has part: feature:61890-61960:-1:exon

S000006578
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:61890-61960:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 62081..62756
location: region:62081-62756:1
so has part: feature:62081-62756:1:region

S000006889
type: SGD
SIO_000068: sgd

position:62081:1
position: 62081
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:62756:1
position: 62756
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62081-62756:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 62142..62474
location: region:62142-62474:1
so has part: feature:62142-62474:1:region

S000006890
type: SGD
SIO_000068: sgd

position:62142:1
position: 62142
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:62474:1
position: 62474
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:62142-62474:1:region

YEL049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAU2
locus tag: YEL049W
so part of: sequence
location: <63728..>64090
location: region:63728-64090:1
so has part: feature:63728-64090:1:exon
subclass of: SO_0000010

856662
type: Gene
SIO_000068: ncbigene

position:63728:1
position: 63728
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:64090:1
position: 64090
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:63728-64090:1:exon

YEL049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAU2
locus tag: YEL049W
product: seripauperin PAU2
transcript id: NM_001178864.1
SIO_010081: YEL049W
subclass of: SO_0000673
so part of: YEL049W
location: <63728..>64090
location: region:63728-64090:1
so has part: feature:63728-64090:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:63728-64090:1:exon

YEL049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAU2
locus tag: YEL049W
note: Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme
codon start: 1
product: seripauperin PAU2
translation: MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRAHLAQYYSFQAAHPTETYPIEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKPAISSALSKDGIYTIAN
SIO_010081: YEL049W
subclass of: SO_0000673
so part of: YEL049W
location: 63728..64090
location: region:63728-64090:1
so has part: feature:63728-64090:1:exon

NP_010865.1
type: Protein
SIO_000068: ncbiprotein

S000000775
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:63728-64090:1:exon

YEL048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TCA17
locus tag: YEL048C
so part of: sequence
location: complement(<64709..>65167)
location: region:64709-65167:-1
so has part: feature:64709-65167:-1:exon
subclass of: SO_0000010

856663
type: Gene
SIO_000068: ncbigene

position:64709:-1
position: 64709
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:65167:-1
position: 65167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:64709-65167:-1:exon

YEL048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TCA17
locus tag: YEL048C
product: Tca17p
transcript id: NM_001178863.1
SIO_010081: YEL048C
subclass of: SO_0000673
so part of: YEL048C
location: complement(<64709..>65167)
location: region:64709-65167:-1
so has part: feature:64709-65167:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:64709-65167:-1:exon

YEL048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TCA17
locus tag: YEL048C
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19220810]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:21453443]
experiment: EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:19220810]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:21453443]
note: Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
codon start: 1
product: Tca17p
translation: MSLRPCFVSLIDESDKPILIYVPNEAENEMNDVLKYNVLSNISLDYFESALVEWHSLDSKPLLKSIFQLEGVSVFAMLIKQTGLKIVIGFEQKSLSGADDEFEAINQIFETVRKIYIRVKCNPLLVSGDEKSIIKSLERKFDELFISTEVEL
SIO_010081: YEL048C
subclass of: SO_0000673
so part of: YEL048C
location: complement(64709..65167)
location: region:64709-65167:-1
so has part: feature:64709-65167:-1:exon

NP_010866.1
type: Protein
SIO_000068: ncbiprotein

S000000774
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:64709-65167:-1:exon

YEL047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FRD1
locus tag: YEL047C
so part of: sequence
location: complement(<65385..>66797)
location: region:65385-66797:-1
so has part: feature:65385-66797:-1:exon
subclass of: SO_0000010

856664
type: Gene
SIO_000068: ncbigene

position:65385:-1
position: 65385
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:66797:-1
position: 66797
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:65385-66797:-1:exon

YEL047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FRD1
locus tag: YEL047C
product: fumarate reductase
transcript id: NM_001178862.3
SIO_010081: YEL047C
subclass of: SO_0000673
so part of: YEL047C
location: complement(<65385..>66797)
location: region:65385-66797:-1
so has part: feature:65385-66797:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:65385-66797:-1:exon

YEL047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FRD1
locus tag: YEL047C
EC number: 1.3.1.6
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9587404]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0016156 fumarate reductase (NADH) activity [PMID:8946166]
experiment: EXISTENCE:genetic interaction:GO:0071454 cellular response to anoxia [PMID:17345583|PMID:9711846]
note: Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
codon start: 1
product: fumarate reductase
translation: MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK
SIO_010081: YEL047C
subclass of: SO_0000673
so part of: YEL047C
location: complement(65385..66797)
location: region:65385-66797:-1
so has part: feature:65385-66797:-1:exon

NP_010867.3
type: Protein
SIO_000068: ncbiprotein

S000000773
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:65385-66797:-1:exon

YEL046C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLY1
locus tag: YEL046C
so part of: sequence
location: complement(<67629..>68792)
location: region:67629-68792:-1
so has part: feature:67629-68792:-1:exon
subclass of: SO_0000010

856665
type: Gene
SIO_000068: ncbigene

position:67629:-1
position: 67629
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:68792:-1
position: 68792
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:67629-68792:-1:exon

YEL046C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLY1
locus tag: YEL046C
product: threonine aldolase GLY1
transcript id: NM_001178861.1
SIO_010081: YEL046C
subclass of: SO_0000673
so part of: YEL046C
location: complement(<67629..>68792)
location: region:67629-68792:-1
so has part: feature:67629-68792:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:67629-68792:-1:exon

YEL046C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLY1
locus tag: YEL046C
EC number: 4.1.2.48
experiment: EXISTENCE:direct assay:GO:0004793 threonine aldolase activity [PMID:9163906]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12676688]
experiment: EXISTENCE:direct assay:GO:0006545 glycine biosynthetic process [PMID:3086094]
experiment: EXISTENCE:direct assay:GO:0006567 threonine catabolic process [PMID:3086094]
experiment: EXISTENCE:direct assay:GO:0008732 L-allo-threonine aldolase activity [PMID:9151955]
note: Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
codon start: 1
product: threonine aldolase GLY1
translation: MTEFELPPKYITAANDLRSDTFTTPTAEMMEAALEASIGDAVYGEDVDTVRLEQTVARMAGKEAGLFCVSGTLSNQIAIRTHLMQPPYSILCDYRAHVYTHEAAGLAILSQAMVVPVVPSNGDYLTLEDIKSHYVPDDGDIHGAPTRLISLENTLHGIVYPLEELVRIKAWCMENGLKLHCDGARIWNAAAQSGVPLKQYGEIFDSISICLSKSMGAPIGSVLVGNLKFVKKATHFRKQQGGGIRQSGMMARMALVNINNDWKSQLLYSHSLAHELAEYCEAKGIPLESPADTNFVFINLKAARMDPDVLVKKGLKYNVKLMGGRVSFHYQVTRDTLEKVKLAISEAFDYAKEHPFDCNGPTQIYRSESTEVDVDGNAIREIKTYKY
SIO_010081: YEL046C
subclass of: SO_0000673
so part of: YEL046C
location: complement(67629..68792)
location: region:67629-68792:-1
so has part: feature:67629-68792:-1:exon

NP_010868.1
type: Protein
SIO_000068: ncbiprotein

S000000772
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:67629-68792:-1:exon

YEL044W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IES6
locus tag: YEL044W
so part of: sequence
location: <69757..>70257
location: region:69757-70257:1
so has part: feature:69757-70257:1:exon
subclass of: SO_0000010

856667
type: Gene
SIO_000068: ncbigene

position:69757:1
position: 69757
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:70257:1
position: 70257
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:69757-70257:1:exon

YEL044W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IES6
locus tag: YEL044W
product: Ies6p
transcript id: NM_001178859.1
SIO_010081: YEL044W
subclass of: SO_0000673
so part of: YEL044W
location: <69757..>70257
location: region:69757-70257:1
so has part: feature:69757-70257:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:69757-70257:1:exon

YEL044W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IES6
locus tag: YEL044W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23207916]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
codon start: 1
product: Ies6p
translation: MSGSRGNSSNSSVSNNSNNNNNNDGGDERLLFLRSVGERNEIGFPSRFKSAHYKKPTRRHKSARQLISDENKRINALLTKANKAAESSTAARRLVPKATYFSVEAPPSIRPAKKYCDVTGLKGFYKSPTNNIRYHNAEIYQLIVKPMAPGVDQEYLKLRGANFVLK
SIO_010081: YEL044W
subclass of: SO_0000673
so part of: YEL044W
location: 69757..70257
location: region:69757-70257:1
so has part: feature:69757-70257:1:exon

NP_010870.1
type: Protein
SIO_000068: ncbiprotein

S000000770
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:69757-70257:1:exon

YEL043W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GTA1
locus tag: YEL043W
so part of: sequence
location: <70478..>73348
location: region:70478-73348:1
so has part: feature:70478-73348:1:exon
subclass of: SO_0000010

856668
type: Gene
SIO_000068: ncbigene

position:70478:1
position: 70478
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:73348:1
position: 73348
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:70478-73348:1:exon

YEL043W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GTA1
locus tag: YEL043W
product: Gta1p
transcript id: NM_001178858.3
SIO_010081: YEL043W
subclass of: SO_0000673
so part of: YEL043W
location: <70478..>73348
location: region:70478-73348:1
so has part: feature:70478-73348:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:70478-73348:1:exon

YEL043W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GTA1
locus tag: YEL043W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: hypothetical protein; proposed role in Golgi vesicle trafficking based on phenotypic profile, presence of a coiled-coil domain often associated with vesicle tethering proteins, and interaction profile process enrichment; may interact with ribosomes, based on co-purification studies; localizes to the ER and cell periphery in HTP studies; contains fibronectin type III domain fold
codon start: 1
product: Gta1p
translation: MPVSVITTVLACLWLSYRLYKFLTIPVSSIVSTLKIKTPPATKVSIDKIATDSVTIHWENEPVKAEDNGSADRNFISHYLLYLNNTQLAIFPNNPNSLYTCCSITGLEAETQYQLDFITINNKGFINKLPSIYCMTKAREANEALKTRKWRRNTITSSTAMQPRNSKSEPAPLPSHYSSVSLSTFSSNITNSATSNNGSNLPAYTSLTTLKDLDSFSIDDLKKILICAQEDLHDVLSQQTSLLQDFQESKLELELELDNLKTHWSHEIDLRKSLKSNIKSLENSKLLTDLKIEKLNKKIDKSKEKISKMRNDMQKWSQEDTELLSKDTIKEKYFKLLNESNASVANINKEIESLQNEISKMEESNKRLNASKKSLITSIVVNANVENDKPIASGELSAVLKKLNDFTLEKNGFLSNAGEEFLSKLNADSSLIKMIKQELSIDQELEANWKLQRSNLLKKISALENQFNEMSLNNRNLKTKLMVQPYKNNGDSLAATNSNNSAEKNRSSGSIQLPLSNNMSRTGSIDLISNNNKSINNSNADSAPPLRLHNPVSYSPSNEPIQPSSSLLSQLTQDTDNRSMLSNHISSNNENKQQPSSYSHALPTTATANATATATATNGHSRSNLWTTAQFAQPSHQQVSTELDQAFEYDNANHLISGLQNMIYDETDYPDNISNYSKGFTTDELDNYWTKQQPQVRSTNESLFSTTGTPMSSYKANPVISPYSSSHLRQTSNATNTNPMHPQSLLAATLNDPSLQSFVRSGSFYSAPQPANSLQNNINGNETENISPRISSDFNLLVPNLSPRLSNDVPIVPGNNTTLTPSHSNILTMNHQPTADNITRRSFHASSPPFNSIWNSNTNQLSPPLEEQYHLDVPVGPKVPAKEPSPKPSHKRNQSNSSISSAWSKFKHKSASSPANADTDIQDSSTPSTSPSGRRMSKLLSKSGMNNLFNPHSHDS
SIO_010081: YEL043W
subclass of: SO_0000673
so part of: YEL043W
location: 70478..73348
location: region:70478-73348:1
so has part: feature:70478-73348:1:exon

NP_010871.3
type: Protein
SIO_000068: ncbiprotein

S000000769
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:70478-73348:1:exon

YEL042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GDA1
locus tag: YEL042W
so part of: sequence
location: <73771..>75327
location: region:73771-75327:1
so has part: feature:73771-75327:1:exon
subclass of: SO_0000010

856669
type: Gene
SIO_000068: ncbigene

position:73771:1
position: 73771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:75327:1
position: 75327
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:73771-75327:1:exon

YEL042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GDA1
locus tag: YEL042W
product: guanosine diphosphatase
transcript id: NM_001178857.1
SIO_010081: YEL042W
subclass of: SO_0000673
so part of: YEL042W
location: <73771..>75327
location: region:73771-75327:1
so has part: feature:73771-75327:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:73771-75327:1:exon

YEL042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GDA1
locus tag: YEL042W
EC number: 3.6.1.42
experiment: EXISTENCE:direct assay:GO:0004382 GDP phosphatase activity [PMID:7506254]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9614179]
experiment: EXISTENCE:direct assay:GO:0045134 UDP phosphatase activity [PMID:11425802]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8391537]
note: Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies
codon start: 1
product: guanosine diphosphatase
translation: MAPIFRNYRFAIGAFAVIMLILLIKTSSIGPPSIARTVTPNASIPKTPEDISILPVNDEPGYLQDSKTEQNYPELADAVKSQTSQTCSEEHKYVIMIDAGSTGSRVHIYKFDVCTSPPTLLDEKFDMLEPGLSSFDTDSVGAANSLDPLLKVAMNYVPIKARSCTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSIMGGDEEGVFAWITTNYLLGNIGANGPKLPTAAVFDLGGGSTQIVFEPTFPINEKMVDGEHKFDLKFGDENYTLYQFSHLGYGLKEGRNKVNSVLVENALKDGKILKGDNTKTHQLSSPCLPPKVNATNEKVTLESKETYTIDFIGPDEPSGAQCRFLTDEILNKDAQCQSPPCSFNGVHQPSLVRTFKESNDIYIFSYFYDRTRPLGMPLSFTLNELNDLARIVCKGEETWNSVFSGIAGSLDELESDSHFCLDLSFQVSLLHTGYDIPLQRELRTGKKIANKEIGWCLGASLPLLKADNWKCKIQSA
SIO_010081: YEL042W
subclass of: SO_0000673
so part of: YEL042W
location: 73771..75327
location: region:73771-75327:1
so has part: feature:73771-75327:1:exon

NP_010872.1
type: Protein
SIO_000068: ncbiprotein

S000000768
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:73771-75327:1:exon

YEL041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YEF1
locus tag: YEL041W
so part of: sequence
location: <75944..>77431
location: region:75944-77431:1
so has part: feature:75944-77431:1:exon
subclass of: SO_0000010

856670
type: Gene
SIO_000068: ncbigene

position:75944:1
position: 75944
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:77431:1
position: 77431
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:75944-77431:1:exon

YEL041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YEF1
locus tag: YEL041W
product: NADH/NAD(+) kinase
transcript id: NM_001178856.1
SIO_010081: YEL041W
subclass of: SO_0000673
so part of: YEL041W
location: <75944..>77431
location: region:75944-77431:1
so has part: feature:75944-77431:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:75944-77431:1:exon

YEL041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YEF1
locus tag: YEL041W
EC number: 2.7.1.86
experiment: EXISTENCE:direct assay:GO:0003951 NAD+ kinase activity [PMID:15978040]
experiment: EXISTENCE:direct assay:GO:0006741 NADP biosynthetic process [PMID:15978040]
experiment: EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:15978040]
note: ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication
codon start: 1
product: NADH/NAD(+) kinase
translation: MKTDRLLINASPETCTKGDAEMDTMDTIDRMTSVKVLAEGKVLSNFEEPGLMRCGYHDAKNWVRRLSSETIVGEDTSNLYPFYVDTAYDVRRLRKDLINAKVDLQVENLIIICNINDISTVFLMREVVEWILRNFHSITVYVQDIFKKSTQFAVGDLCKDSNCSKNRVKYWSKEFVKKHDSFFDLMITLGGDGTVLFASSIFTKDVPPIVPFALGSLGFLTNFEFQNFKETLKHILTDEVRINLRMRLQCKLYRRNKPEIDAATGRKICYIDFISEHHVLNEVTIDRGPAPCLSLLELYGNDSLMTKVQGDGLIVATPTGSTAYSLSAGGSLISPSVNAIAVTPICPHTLSFRPIILPDSMELKVRVDMNSRGTSWVNFDGKDRVELKQGDYVVITASPYSVPTIESSASEFFESISKNLNWNDREEQKPFAHILSPKNQEKYRLDSSKNGNDTISNPLESSCISSDAQDEERKSVTETETEIVVERTRQAHFAI
SIO_010081: YEL041W
subclass of: SO_0000673
so part of: YEL041W
location: 75944..77431
location: region:75944-77431:1
so has part: feature:75944-77431:1:exon

NP_010873.1
type: Protein
SIO_000068: ncbiprotein

S000000767
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:75944-77431:1:exon

YEL040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CRH2
gene: UTR2
locus tag: YEL040W
gene synonym: CRH2
so part of: sequence
location: <78053..>79456
location: region:78053-79456:1
so has part: feature:78053-79456:1:exon
subclass of: SO_0000010

856671
type: Gene
SIO_000068: ncbigene

position:78053:1
position: 78053
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79456:1
position: 79456
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:78053-79456:1:exon

YEL040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CRH2
gene: UTR2
locus tag: YEL040W
gene synonym: CRH2
product: chitin transglycosylase UTR2
transcript id: NM_001178855.3
SIO_010081: YEL040W
subclass of: SO_0000673
so part of: YEL040W
location: <78053..>79456
location: region:78053-79456:1
so has part: feature:78053-79456:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:78053-79456:1:exon

YEL040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CRH2
gene: UTR2
locus tag: YEL040W
gene synonym: CRH2
experiment: EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:12045225]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]
experiment: EXISTENCE:direct assay:GO:0016757 glycosyltransferase activity [PMID:23919454]
experiment: EXISTENCE:genetic interaction:GO:0006037 cell wall chitin metabolic process [PMID:18694928]
experiment: EXISTENCE:genetic interaction:GO:0016757 glycosyltransferase activity [PMID:18694928]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18694928]
experiment: EXISTENCE:mutant phenotype:GO:0006037 cell wall chitin metabolic process [PMID:18694928]
experiment: EXISTENCE:mutant phenotype:GO:0016757 glycosyltransferase activity [PMID:18694928]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18694928]
note: Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
codon start: 1
product: chitin transglycosylase UTR2
translation: MAIVNSWLICLVSIFSFVVRVEAATFCNATQACPEDKPCCSQYGECGTGQYCLNNCDVRYSFSHDSCMPVPICKSSSTKFKDYSSKLGNANTFLGNVSEADWLYTGDVLDYDDEESLILAMPKNSGGTVLSSTRAVWYGKVSARIKTSHLAGVVTGFILYSGAGDELDYEFVGADLETAQTNFYWESVLNYTNSANISTTDTFENYHTYELDWHEDYVTWSIDGVVGRTLYKNETYNATTQKYQYPQTPSKVDISIWPGGNSTNAPGTIAWSGGEINWDASDISNPGYYYAIVNEVNITCYDPPSDTKKNGTSAYVYTSSSEFLAKDIAITDDEVMMDSDEGSGLDPHKGATTSSTQKSSSSTATSSSKTSSDHSSSTKKSSKTSSTASSSSSSSSSSSSSSSTATKNGDKVVSSVSSSVTSQTQTTSSVSGSASSSTSSMSGNNAGANVAANWRLTVLCVILGYVL
SIO_010081: YEL040W
subclass of: SO_0000673
so part of: YEL040W
location: 78053..79456
location: region:78053-79456:1
so has part: feature:78053-79456:1:exon

NP_010874.3
type: Protein
SIO_000068: ncbiprotein

S000000766
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:78053-79456:1:exon

YEL039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CYC7
locus tag: YEL039C
so part of: sequence
location: complement(<79636..>79977)
location: region:79636-79977:-1
so has part: feature:79636-79977:-1:exon
subclass of: SO_0000010

856672
type: Gene
SIO_000068: ncbigene

position:79636:-1
position: 79636
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:79977:-1
position: 79977
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:79636-79977:-1:exon

YEL039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CYC7
locus tag: YEL039C
product: cytochrome c isoform 2
transcript id: NM_001178854.1
SIO_010081: YEL039C
subclass of: SO_0000673
so part of: YEL039C
location: complement(<79636..>79977)
location: region:79636-79977:-1
so has part: feature:79636-79977:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:79636-79977:-1:exon

YEL039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CYC7
locus tag: YEL039C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:8636074]
experiment: EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:7814361]
experiment: EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:7814361]
experiment: EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:7814361]
note: Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication
codon start: 1
product: cytochrome c isoform 2
translation: MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGIFGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDLITYMTKAAK
SIO_010081: YEL039C
subclass of: SO_0000673
so part of: YEL039C
location: complement(79636..79977)
location: region:79636-79977:-1
so has part: feature:79636-79977:-1:exon

NP_010875.1
type: Protein
SIO_000068: ncbiprotein

S000000765
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:79636-79977:-1:exon

YEL038W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTR4
locus tag: YEL038W
so part of: sequence
location: <80462..>81145
location: region:80462-81145:1
so has part: feature:80462-81145:1:exon
subclass of: SO_0000010

856673
type: Gene
SIO_000068: ncbigene

position:80462:1
position: 80462
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:81145:1
position: 81145
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:80462-81145:1:exon

YEL038W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTR4
locus tag: YEL038W
product: putative acireductone synthase UTR4
transcript id: NM_001178853.1
SIO_010081: YEL038W
subclass of: SO_0000673
so part of: YEL038W
location: <80462..>81145
location: region:80462-81145:1
so has part: feature:80462-81145:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:80462-81145:1:exon

YEL038W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTR4
locus tag: YEL038W
EC number: 3.1.3.77
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:18625006]
note: Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus
codon start: 1
product: putative acireductone synthase UTR4
translation: MGDNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDSPVSNILSQFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADAIDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTETQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQKYQVYKNFETL
SIO_010081: YEL038W
subclass of: SO_0000673
so part of: YEL038W
location: 80462..81145
location: region:80462-81145:1
so has part: feature:80462-81145:1:exon

NP_010876.2
type: Protein
SIO_000068: ncbiprotein

S000000764
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:80462-81145:1:exon

YEL037C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD23
locus tag: YEL037C
so part of: sequence
location: complement(<81407..>82603)
location: region:81407-82603:-1
so has part: feature:81407-82603:-1:exon
subclass of: SO_0000010

856674
type: Gene
SIO_000068: ncbigene

position:81407:-1
position: 81407
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:82603:-1
position: 82603
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:81407-82603:-1:exon

YEL037C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD23
locus tag: YEL037C
product: Rad23p
transcript id: NM_001178852.3
SIO_010081: YEL037C
subclass of: SO_0000673
so part of: YEL037C
location: complement(<81407..>82603)
location: region:81407-82603:-1
so has part: feature:81407-82603:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:81407-82603:-1:exon

YEL037C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD23
locus tag: YEL037C
experiment: EXISTENCE:direct assay:GO:0000111 nucleotide-excision repair factor 2 complex [PMID:7768886]
experiment: EXISTENCE:direct assay:GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [PMID:20016784]
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9813069|PMID:9837874]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006517 protein deglycosylation [PMID:20016784]
experiment: EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11323716]
experiment: EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:25311859|PMID:15117949|PMID:15242647]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26150418]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:15167887]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19889839]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:15121879]
note: Proteasome-associated ubiquitin receptor; K48-specific Ub chain binding protein that recruits substrates to the proteasome; subunit of nuclear excision repair factor 2 (NER2) with Rad4p that binds damaged DNA during NER, linking repair to proteolysis; NER2 binds DDR gene promoters to repress transcription in the absence of damage; stimulates Png1p-induced protein deglycosylation; contains a Ub-like (UBL) and two Ub-associated (UBA) domains; UBA2 protects Rad23p from proteasomal degradation
codon start: 1
product: Rad23p
translation: MVSLTFKNFKKEKVPLDLEPSNTILETKTKLAQSISCEESQIKLIYSGKVLQDSKTVSECGLKDGDQVVFMVSQKKSTKTKVTEPPIAPESATTPGRENSTEASPSTDASAAPAATAPEGSQPQEEQTATTERTESASTPGFVVGTERNETIERIMEMGYQREEVERALRAAFNNPDRAVEYLLMGIPENLRQPEPQQQTAAAAEQPSTAATTAEQPAEDDLFAQAAQGGNASSGALGTTGGATDAAQGGPPGSIGLTVEDLLSLRQVVSGNPEALAPLLENISARYPQLREHIMANPEVFVSMLLEAVGDNMQDVMEGADDMVEGEDIEVTGEAAAAGLGQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFACDKNEEAAANILFSDHAD
SIO_010081: YEL037C
subclass of: SO_0000673
so part of: YEL037C
location: complement(81407..82603)
location: region:81407-82603:-1
so has part: feature:81407-82603:-1:exon

NP_010877.3
type: Protein
SIO_000068: ncbiprotein

S000000763
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:81407-82603:-1:exon

YEL036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GEM3
alternative label: MNN8
gene: ANP1
locus tag: YEL036C
gene synonym: GEM3; MNN8
so part of: sequence
location: complement(<83050..>84552)
location: region:83050-84552:-1
so has part: feature:83050-84552:-1:exon
subclass of: SO_0000010

856675
type: Gene
SIO_000068: ncbigene

position:83050:-1
position: 83050
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:84552:-1
position: 84552
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:83050-84552:-1:exon

YEL036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GEM3
alternative label: MNN8
gene: ANP1
locus tag: YEL036C
gene synonym: GEM3; MNN8
product: Anp1p
transcript id: NM_001178851.1
SIO_010081: YEL036C
subclass of: SO_0000673
so part of: YEL036C
location: complement(<83050..>84552)
location: region:83050-84552:-1
so has part: feature:83050-84552:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:83050-84552:-1:exon

YEL036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GEM3
alternative label: MNN8
gene: ANP1
locus tag: YEL036C
gene synonym: GEM3; MNN8
experiment: EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10037752]
experiment: EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]
experiment: EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:9430634]
experiment: EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9430634]
experiment: EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9430634]
note: Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
codon start: 1
product: Anp1p
translation: MKYNNRKLSFNPTTVSIAGTLLTVFFLTRLVLSFFSISLFQLVTFQGIFKPYVPDFKNTPSVEFYDLRNYQGNKDGWQQGDRILFCVPLRDASEHLPMFFNHLNTMTYPHNLIDLSFLVSDSSDNTMGVLLSNLQMAQSQQDKSKRFGNIEIYEKDFGQIIGQSFSDRHGFGAQGPRRKLMARARNWLGSVALKPYHSWVYWRDVDVETIPTTIMEDLMHHDKDVIVPNVWRPLPDWLGNIQPYDLNSWKESEGGLQLADSLDEDAVIVEGYPEYATWRPHLAYMRDPNGNPEDEMELDGIGGVSILAKAKVFRTGSHFPAFSFEKHAETEAFGRLSRRMNYNVIGLPHYVIWHIYEPSSDDLKHMAWMAEEEKRKLEEERIREFYNKIWEIGFEDVRDQWNEERDSILKNIDSTLNNKVTVDWSEEGDGSELVDSKGDFVSPNNQQQQQQQQQQQQQQQQQQQQQQLDGNPQGKPLDDNDKNKKKHPKEVPLDFDPDRN
SIO_010081: YEL036C
subclass of: SO_0000673
so part of: YEL036C
location: complement(83050..84552)
location: region:83050-84552:-1
so has part: feature:83050-84552:-1:exon

NP_010878.1
type: Protein
SIO_000068: ncbiprotein

S000000762
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:83050-84552:-1:exon

YEL035C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UTR5
locus tag: YEL035C
so part of: sequence
location: complement(<85045..>85545)
location: region:85045-85545:-1
so has part: feature:85045-85545:-1:exon
subclass of: SO_0000010

856676
type: Gene
SIO_000068: ncbigene

position:85045:-1
position: 85045
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:85545:-1
position: 85545
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85045-85545:-1:exon

YEL035C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UTR5
locus tag: YEL035C
product: Utr5p
transcript id: NM_001178850.1
SIO_010081: YEL035C
subclass of: SO_0000673
so part of: YEL035C
location: complement(<85045..>85545)
location: region:85045-85545:-1
so has part: feature:85045-85545:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85045-85545:-1:exon

YEL035C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UTR5
locus tag: YEL035C
note: hypothetical protein; originally considered essential but deletion overlapped the TATA box of neighboring essential gene HYP2, while deletion that avoids the HYP2 TATA box is viable; transcription may be regulated by Gcr1p
codon start: 1
product: Utr5p
translation: MSRYGKNLVHYIIVEHDDQRGQKPIDDDDEKNFYYHCSFTFETFFRATAFLLAPAVCAVREVPCRLTRTRYNATEYIEGYGWMISLQQGLGVAEFYRPWPLSVQLQRYTTPSRRSRFAVLTPQRKCHQNEANGQDLSLLILLSRIYPLCSNTSQTRRVAARKGKLS
SIO_010081: YEL035C
subclass of: SO_0000673
so part of: YEL035C
location: complement(85045..85545)
location: region:85045-85545:-1
so has part: feature:85045-85545:-1:exon

NP_010879.1
type: Protein
SIO_000068: ncbiprotein

S000000761
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85045-85545:-1:exon

YEL034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TIF51A
gene: HYP2
locus tag: YEL034W
gene synonym: TIF51A
so part of: sequence
location: <85676..>86149
location: region:85676-86149:1
so has part: feature:85676-86149:1:exon
subclass of: SO_0000010

856677
type: Gene
SIO_000068: ncbigene

position:85676:1
position: 85676
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:86149:1
position: 86149
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:85676-86149:1:exon

YEL034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TIF51A
gene: HYP2
locus tag: YEL034W
gene synonym: TIF51A
product: translation elongation factor eIF-5A
transcript id: NM_001178849.3
SIO_010081: YEL034W
subclass of: SO_0000673
so part of: YEL034W
location: <85676..>86149
location: region:85676-86149:1
so has part: feature:85676-86149:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:85676-86149:1:exon

YEL034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TIF51A
gene: HYP2
locus tag: YEL034W
gene synonym: TIF51A
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:19120453]
experiment: EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:21451136]
experiment: EXISTENCE:direct assay:GO:0003746 translation elongation factor activity [PMID:19424157]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:16215987]
experiment: EXISTENCE:direct assay:GO:0045901 positive regulation of translational elongation [PMID:19424157]
experiment: EXISTENCE:direct assay:GO:0045905 positive regulation of translational termination [PMID:19424157]
experiment: EXISTENCE:direct assay:GO:0045948 positive regulation of translational initiation [PMID:21451136]
experiment: EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:11861547]
experiment: EXISTENCE:genetic interaction:GO:0006452 translational frameshifting [PMID:19424157]
experiment: EXISTENCE:genetic interaction:GO:0045901 positive regulation of translational elongation [PMID:19338753|PMID:19424157]
experiment: EXISTENCE:mutant phenotype:GO:0003746 translation elongation factor activity [PMID:19424157]
experiment: EXISTENCE:mutant phenotype:GO:0045901 positive regulation of translational elongation [PMID:19338753|PMID:19424157]
experiment: EXISTENCE:mutant phenotype:GO:1903272 positive regulation of cytoplasmic translational elongation through polyproline stretches [PMID:24923804]
note: Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has paralog ANB1 that arose from whole genome duplication; in humans EIF5A variants cause a disorder characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphism; human EIF5A complements inviability of yeast hyp2 anb1 double null mutant
codon start: 1
product: translation elongation factor eIF-5A
translation: MSDEEHTFETADAGSSATYPMQCSALRKNGFVVIKSRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMEVPVVKRNEYQLLDIDDGFLSLMNMDGDTKDDVKAPEGELGDSLQTAFDEGKDLMVTIISAMGEEAAISFKEAARTD
SIO_010081: YEL034W
subclass of: SO_0000673
so part of: YEL034W
location: 85676..86149
location: region:85676-86149:1
so has part: feature:85676-86149:1:exon

NP_010880.3
type: Protein
SIO_000068: ncbiprotein

S000000760
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:85676-86149:1:exon

YEL033W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MTC7
locus tag: YEL033W
so part of: sequence
location: <86179..>86598
location: region:86179-86598:1
so has part: feature:86179-86598:1:exon
subclass of: SO_0000010

856678
type: Gene
SIO_000068: ncbigene

position:86179:1
position: 86179
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:86598:1
position: 86598
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86179-86598:1:exon

YEL033W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MTC7
locus tag: YEL033W
product: Mtc7p
transcript id: NM_001178848.1
SIO_010081: YEL033W
subclass of: SO_0000673
so part of: YEL033W
location: <86179..>86598
location: region:86179-86598:1
so has part: feature:86179-86598:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:86179-86598:1:exon

YEL033W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MTC7
locus tag: YEL033W
note: hypothetical protein; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
codon start: 1
product: Mtc7p
translation: MKKEKKTPTPLPSHHVLFAEPGFFLCNFFFVLLKHTQINPFFYFLFILLFIIYIAIIYFVFIRISHFSFSLCRQCNSLGRMIFMCAYLPAASSRSVANPALPPQKKKKKKKKGTLRTGEVEEQAKGNISFDLCGKQNFQ
SIO_010081: YEL033W
subclass of: SO_0000673
so part of: YEL033W
location: 86179..86598
location: region:86179-86598:1
so has part: feature:86179-86598:1:exon

NP_010881.1
type: Protein
SIO_000068: ncbiprotein

S000000759
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86179-86598:1:exon

YNCE0005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0005W
so part of: sequence
location: 86604..86685
location: region:86604-86685:1
so has part: feature:86604-86685:1:exon
subclass of: SO_0000663

856679
type: Gene
SIO_000068: ncbigene

position:86604:1
position: 86604
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:86685:1
position: 86685
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86604-86685:1:exon

YNCE0005W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0005W
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0005W
subclass of: SO_0000673
so part of: YNCE0005W
location: 86604..86685
location: region:86604-86685:1
so has part: feature:86604-86685:1:exon

S000006724
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86604-86685:1:exon

YEL032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MCM3
locus tag: YEL032W
so part of: sequence
location: <86937..>89852
location: region:86937-89852:1
so has part: feature:86937-89852:1:exon
subclass of: SO_0000010

856680
type: Gene
SIO_000068: ncbigene

position:86937:1
position: 86937
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:89852:1
position: 89852
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:86937-89852:1:exon

YEL032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MCM3
locus tag: YEL032W
product: MCM DNA helicase complex subunit MCM3
transcript id: NM_001178847.1
SIO_010081: YEL032W
subclass of: SO_0000673
so part of: YEL032W
location: <86937..>89852
location: region:86937-89852:1
so has part: feature:86937-89852:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:86937-89852:1:exon

YEL032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MCM3
locus tag: YEL032W
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9554851]
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410|PMID:8224843]
experiment: EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10704410|PMID:8224843|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12480933]
experiment: EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:18657510]
experiment: EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:16531994]
experiment: EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]
experiment: EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]
experiment: EXISTENCE:direct assay:GO:1904931 MCM complex binding [PMID:26912723]
experiment: EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]
experiment: EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:12060653]
experiment: EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:12480933]
experiment: EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:19064704]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:19064704]
experiment: EXISTENCE:mutant phenotype:GO:1902975 mitotic DNA replication initiation [PMID:8224843]
experiment: EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:9554851]
note: Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex
codon start: 1
product: MCM DNA helicase complex subunit MCM3
translation: MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV
SIO_010081: YEL032W
subclass of: SO_0000673
so part of: YEL032W
location: 86937..89852
location: region:86937-89852:1
so has part: feature:86937-89852:1:exon

NP_010882.1
type: Protein
SIO_000068: ncbiprotein

S000000758
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:86937-89852:1:exon

YEL031W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: COD1
alternative label: PER9
alternative label: PIO1
gene: SPF1
locus tag: YEL031W
gene synonym: COD1; PER9; PIO1
so part of: sequence
location: <90258..>93905
location: region:90258-93905:1
so has part: feature:90258-93905:1:exon
subclass of: SO_0000010

856681
type: Gene
SIO_000068: ncbigene

position:90258:1
position: 90258
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:93905:1
position: 93905
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:90258-93905:1:exon

YEL031W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: COD1
alternative label: PER9
alternative label: PIO1
gene: SPF1
locus tag: YEL031W
gene synonym: COD1; PER9; PIO1
product: ion-transporting P-type ATPase SPF1
transcript id: NM_001178846.3
SIO_010081: YEL031W
subclass of: SO_0000673
so part of: YEL031W
location: <90258..>93905
location: region:90258-93905:1
so has part: feature:90258-93905:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:90258-93905:1:exon

YEL031W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: COD1
alternative label: PER9
alternative label: PIO1
gene: SPF1
locus tag: YEL031W
gene synonym: COD1; PER9; PIO1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12058017|PMID:22745129|PMID:30785834]
experiment: EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:11791712]
experiment: EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:30785834]
experiment: EXISTENCE:mutant phenotype:GO:0006874 cellular calcium ion homeostasis [PMID:12058017]
experiment: EXISTENCE:mutant phenotype:GO:0030026 cellular manganese ion homeostasis [PMID:24392018]
experiment: EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:22918956|PMID:30785834]
note: P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid and sterol composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; null mutation is complemented by human Parkinson disease-related ATP13A1
codon start: 1
product: ion-transporting P-type ATPase SPF1
translation: MTKKSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFQQYDRYIKGPEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKCKGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEALMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYSAAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRVLALASKSLPKMSQSKIDDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGMKMMYIKQTEFMARWNQPQPPVPEPIAHLFPPGPKNPHYLKALESKGTVITPEIRKAVEEANSKPVEVIKPNGLSEKKPADLASLLLNSAGDAQGDEAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVKIASK
SIO_010081: YEL031W
subclass of: SO_0000673
so part of: YEL031W
location: 90258..93905
location: region:90258-93905:1
so has part: feature:90258-93905:1:exon

NP_010883.3
type: Protein
SIO_000068: ncbiprotein

S000000757
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:90258-93905:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS508; Autonomously Replicating Sequence
so part of: sequence
location: 93978..94218
location: region:93978-94218:1
so has part: feature:93978-94218:1:region

S000077381
type: SGD
SIO_000068: sgd

position:93978:1
position: 93978
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:94218:1
position: 94218
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:93978-94218:1:region

YEL030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSC3
gene: ECM10
locus tag: YEL030W
gene synonym: SSC3
so part of: sequence
location: <94644..>96578
location: region:94644-96578:1
so has part: feature:94644-96578:1:exon
subclass of: SO_0000010

856682
type: Gene
SIO_000068: ncbigene

position:94644:1
position: 94644
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:96578:1
position: 96578
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:94644-96578:1:exon

YEL030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSC3
gene: ECM10
locus tag: YEL030W
gene synonym: SSC3
product: Hsp70 family ATPase ECM10
transcript id: NM_001178845.1
SIO_010081: YEL030W
subclass of: SO_0000673
so part of: YEL030W
location: <94644..>96578
location: region:94644-96578:1
so has part: feature:94644-96578:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:94644-96578:1:exon

YEL030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSC3
gene: ECM10
locus tag: YEL030W
gene synonym: SSC3
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11150530|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0006626 protein targeting to mitochondrion [PMID:11150530]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:12943685]
note: Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication
codon start: 1
product: Hsp70 family ATPase ECM10
translation: MLPSWKAFKAHNILRILTRFQSTKIPDAVIGIDLGTTNSAVAIMEGKVPRIIENAEGSRTTPSVVAFTKDGERLVGEPAKRQSVINSENTLFATKRLIGRRFEDAEVQRDINQVPFKIVKHSNGDAWVEARNRTYSPAQIGGFILNKMKETAEAYLAKSVKNAVVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALAYGLDKSEPKVIAVFDLGGGTFDISILDIDNGIFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKETGIDLSNDRMAVQRIREAAEKAKIELSSTLSTEINLPFITADAAGPKHIRMPFSRVQLENITAPLIDRTVDPVKKALKDARITASDISDVLLVGGMSRMPKVADTVKKLFGKDASKAVNPDEAVALGAAIQAAVLSGEVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEVKVFQGERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDSSITVAGASGLSDTEIDRMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKEFEGKLDKTDSQRLKDQISSLRELVSRSQAGDEVNDDDVGTKIDNLRTSSMKLFEQLYKNSDNPETKNGRENK
SIO_010081: YEL030W
subclass of: SO_0000673
so part of: YEL030W
location: 94644..96578
location: region:94644-96578:1
so has part: feature:94644-96578:1:exon

NP_010884.1
type: Protein
SIO_000068: ncbiprotein

S000000756
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:94644-96578:1:exon

YEL029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUD16
locus tag: YEL029C
so part of: sequence
location: complement(<96858..>97796)
location: region:96858-97796:-1
so has part: feature:96858-97796:-1:exon
subclass of: SO_0000010

856683
type: Gene
SIO_000068: ncbigene

position:96858:-1
position: 96858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:97796:-1
position: 97796
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:96858-97796:-1:exon

YEL029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUD16
locus tag: YEL029C
product: putative pyridoxal kinase BUD16
transcript id: NM_001178844.1
SIO_010081: YEL029C
subclass of: SO_0000673
so part of: YEL029C
location: complement(<96858..>97796)
location: region:96858-97796:-1
so has part: feature:96858-97796:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:96858-97796:-1:exon

YEL029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUD16
locus tag: YEL029C
EC number: 2.7.1.35
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]
experiment: EXISTENCE:genetic interaction:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:17696614]
experiment: EXISTENCE:mutant phenotype:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:17696614]
note: Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; localizes to cytosol and peroxisomes; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)
codon start: 1
product: putative pyridoxal kinase BUD16
translation: MPRLLATQSHVVHGYVGNKAATFPLQCLGWDVDCCNSVQFSNHTGYGLDKVFGTITRETDLKELLSGLFDNFSQDYQALLSGYLPNKNSVRCMGTYYAKFKEANPEMIWLMDPVMGDEGQLYVSEDVIPEYRKLALSPKQLVDIITPNQFELEILYGGEIKTKEHLKKALKKLHQTIPVIIVTSCDCKMFDDKDFIYCVASMEGKTPIVYRVPFIDSYFTGVGDLFSALLLDRVYKILSNPTTTLKFEDQVNNVLNVIQKVLKITRSYASGKMKAKMGSALEMKEMELRLIESRDIYETINIHQTDYIYARL
SIO_010081: YEL029C
subclass of: SO_0000673
so part of: YEL029C
location: complement(96858..97796)
location: region:96858-97796:-1
so has part: feature:96858-97796:-1:exon

NP_010885.1
type: Protein
SIO_000068: ncbiprotein

S000000755
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:96858-97796:-1:exon

YEL028W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL028W
so part of: sequence
location: <98668..>99129
location: region:98668-99129:1
so has part: feature:98668-99129:1:exon
subclass of: SO_0000010

856684
type: Gene
SIO_000068: ncbigene

position:98668:1
position: 98668
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:99129:1
position: 99129
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:98668-99129:1:exon

YEL028W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL028W
product: uncharacterized protein
transcript id: NM_001348820.1
SIO_010081: YEL028W
subclass of: SO_0000673
so part of: YEL028W
location: <98668..>99129
location: region:98668-99129:1
so has part: feature:98668-99129:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:98668-99129:1:exon

YEL028W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL028W
note: hypothetical protein; conserved among S. cerevisiae strains; YEL028W is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MKITITSLLFFLVMIVELASAGTLLHNGANLPSLRDNTTLTDARNVLKYLQVLGFPSNKIAATDTVGTFIIFSNRTEANTTAMTKTVSYCYRNYGHSFYFTHYKYDYFPSGISYMAKLGDATVNHTDLPHFRNNKRLTTQELNAFQHPIVEFQ
SIO_010081: YEL028W
subclass of: SO_0000673
so part of: YEL028W
location: 98668..99129
location: region:98668-99129:1
so has part: feature:98668-99129:1:exon

NP_001335764.1
type: Protein
SIO_000068: ncbiprotein

S000000754
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:98668-99129:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(99490..99664)
location: region:99490-99664:-1
so has part: feature:99490-99664:-1:region

S000006886
type: SGD
SIO_000068: sgd

position:99490:-1
position: 99490
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:99664:-1
position: 99664
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:99490-99664:-1:region

YNCE0006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IMT4
locus tag: YNCE0006W
so part of: sequence
location: 100133..100204
location: region:100133-100204:1
so has part: feature:100133-100204:1:exon
subclass of: SO_0000663

856685
type: Gene
SIO_000068: ncbigene

position:100133:1
position: 100133
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:100204:1
position: 100204
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100133-100204:1:exon

YNCE0006W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: IMT4
locus tag: YNCE0006W
product: tRNA-Met
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006413 translational initiation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]
experiment: EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]
experiment: EXISTENCE:direct assay:GO:0071074 eukaryotic initiation factor eIF2 binding [PMID:14698289]
note: Methionine initiator tRNA (tRNA-Met); predicted by tRNAscan-SE analysis; one of four initiator methionine tRNAs in yeast that are functional for translation
SIO_010081: YNCE0006W
subclass of: SO_0000673
so part of: YNCE0006W
location: 100133..100204
location: region:100133-100204:1
so has part: feature:100133-100204:1:exon

S000006660
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100133-100204:1:exon

YEL027W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CLS7
alternative label: CUP5
alternative label: GEF2
gene: VMA3
locus tag: YEL027W
gene synonym: CLS7; CUP5; GEF2
so part of: sequence
location: <100769..>101251
location: region:100769-101251:1
so has part: feature:100769-101251:1:exon
subclass of: SO_0000010

856686
type: Gene
SIO_000068: ncbigene

position:100769:1
position: 100769
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:101251:1
position: 101251
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:100769-101251:1:exon

YEL027W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CLS7
alternative label: CUP5
alternative label: GEF2
gene: VMA3
locus tag: YEL027W
gene synonym: CLS7; CUP5; GEF2
product: H(+)-transporting V0 sector ATPase subunit c
transcript id: NM_001178842.3
SIO_010081: YEL027W
subclass of: SO_0000673
so part of: YEL027W
location: <100769..>101251
location: region:100769-101251:1
so has part: feature:100769-101251:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:100769-101251:1:exon

YEL027W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CLS7
alternative label: CUP5
alternative label: GEF2
gene: VMA3
locus tag: YEL027W
gene synonym: CLS7; CUP5; GEF2
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]
experiment: EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:2145283]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:9434348]
experiment: EXISTENCE:mutant phenotype:GO:0006879 cellular iron ion homeostasis [PMID:9434348]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:2145283]
experiment: EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:2145283]
experiment: EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:2145283]
note: Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis
codon start: 1
product: H(+)-transporting V0 sector ATPase subunit c
translation: MTELCPVYAPFFGAIGCASAIIFTSLGAAYGTAKSGVGICATCVLRPDLLFKNIVPVIMAGIIAIYGLVVSVLVCYSLGQKQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGSSQQPRLFVGMILILIFAEVLGLYGLIVALLLNSRATQDVVC
SIO_010081: YEL027W
subclass of: SO_0000673
so part of: YEL027W
location: 100769..101251
location: region:100769-101251:1
so has part: feature:100769-101251:1:exon

NP_010887.3
type: Protein
SIO_000068: ncbiprotein

S000000753
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:100769-101251:1:exon

YEL026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNU13
locus tag: YEL026W
so part of: sequence
location: <101943..>102323
location: region:101943-102323:1
so has part: feature:101943-102323:1:exon
subclass of: SO_0000010

856687
type: Gene
SIO_000068: ncbigene

position:101943:1
position: 101943
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:102323:1
position: 102323
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:101943-102323:1:exon

YEL026W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SNU13
locus tag: YEL026W
product: RNA binding protein SNU13
transcript id: NM_001178841.1
SIO_010081: YEL026W
subclass of: SO_0000673
so part of: YEL026W
location: <101943..>102323
location: region:101943-102323:1
so has part: feature:101943-102323:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:101943-102323:1:exon

YEL026W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SNU13
locus tag: YEL026W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:17631273|PMID:14730029]
experiment: EXISTENCE:direct assay:GO:0031428 box C/D RNP complex [PMID:11081632]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:17631273|PMID:14730029]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:1905216 positive regulation of RNA binding [PMID:23509373]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:14730029|PMID:11720284]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14730029]
experiment: EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:14730029]
note: RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
codon start: 1
product: RNA binding protein SNU13
translation: MSAPNPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLNRGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPVIAASITTNDASAIKTQIYAVKDKIETLLI
SIO_010081: YEL026W
subclass of: SO_0000673
so part of: YEL026W
location: 101943..102323
location: region:101943-102323:1
so has part: feature:101943-102323:1:exon

NP_010888.1
type: Protein
SIO_000068: ncbiprotein

S000000752
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:101943-102323:1:exon

YEL025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL025C
so part of: sequence
location: complement(<102581..>106147)
location: region:102581-106147:-1
so has part: feature:102581-106147:-1:exon
subclass of: SO_0000010

856688
type: Gene
SIO_000068: ncbigene

position:102581:-1
position: 102581
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:106147:-1
position: 106147
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:102581-106147:-1:exon

YEL025C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL025C
product: uncharacterized protein
transcript id: NM_001178840.1
SIO_010081: YEL025C
subclass of: SO_0000673
so part of: YEL025C
location: complement(<102581..>106147)
location: region:102581-106147:-1
so has part: feature:102581-106147:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:102581-106147:-1:exon

YEL025C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL025C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
codon start: 1
product: uncharacterized protein
translation: MARQDETDCKKLDSNSAFLPLCITSYRSKDEAEKLVSCLHHEGSYFLCFSYGLYTGTSNELKAKVEFALDGPFVVNYATVPMFMSASFCHLLMFNDGSIKGFKCENNKFEIIYDSNVAPKLDTISLLTSSWLNASFEGVLYTCNKNISYDSDLHTLCTTIYSFDFREGIVERFYATDGEEIISFDFISREDLLDDATCTGKSHVYFLCLLKSCYSENLFLKEYNLAGKHGSRKFDLNEYRQYNLLPICDNEFCYMKVVCGHTIVVLTTNYTQIINIKASGLTNGAFFNNKGLPNVENYQFLKDSYDVIYERSVILLTISDVYANKYTAKIHTRSLHRDHVLKELQWTKERVFKPPKHDLCDVILQLPREKYIAVTRINGVNFISKDHRGSKLEKVKSGPAYTNKVYLASQVIGNKGTDIDSLLLGGSFNSRRGFLEKKILVYDKTLFKLVTSSKALVENVTDFWVTDLALNGGDEFAYESGGLIYKNGIFLMDEPYDYGLFVSRTGKVLKAGMDGSTGEFRQVDFLQSNHNSSTMFCYPVQNSKLRISILEAKSGFLRKKEEFFIHGLNSKESIVSCFSDGAEKYLFVIYLDGVFSVWNANQKKVATSHPDYSFIAYDQLIKISWLSKKHKHDSIYVIASSYTGCVRVYKSESNFLRVDLEIHSLYDQKLELLDTIPSLPLVFLYNDKEIILLNLQNMSYGCIQLGLVPRRMRIRPGKALFSLCVLDYDSRISIFEFGSTFYREGFTKQMTSLKPQLENHIFYLPSIPVELYTVPNNLNQAVVCLVDSNSRQYKLMLFNYASMKAVSTFSFSDEKYLHAVVKPLWPEQNSIYLSQRPFYGNKFVVCLGVGEKRTKFWLFEIRNNNITQLYANYLEDCIFSVFIYYECNLVLFSGDSGIAAYKINMLKEGAEILEAYSFPALSSINHIGLPAYMSGDYLVQFEILRDFLRTRFPIRTSIVYPSEYPECPYLGFKRLGSITQVATKIIPKKLREPKNDCLASDKNYLLGRLSDLSCATLKYSNRSYVATIGIDNTLTIYEDSKLSVDKGGLAMPYLKIRLPNKIISLAAIPDGFQNLQICPNFNSQRLEGVIPLFLLCGTEGQIYIISEFIGELWMRTLHDYKKIKLECKRAFRRSEKSMRNVTKQYSVSKETGINESGFDELARNSKRRHIDHSPYKTIDFFDPVKLKR
SIO_010081: YEL025C
subclass of: SO_0000673
so part of: YEL025C
location: complement(102581..106147)
location: region:102581-106147:-1
so has part: feature:102581-106147:-1:exon

NP_010889.1
type: Protein
SIO_000068: ncbiprotein

S000000751
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:102581-106147:-1:exon

YEL024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RIP1
locus tag: YEL024W
so part of: sequence
location: <107260..>107907
location: region:107260-107907:1
so has part: feature:107260-107907:1:exon
subclass of: SO_0000010

856689
type: Gene
SIO_000068: ncbigene

position:107260:1
position: 107260
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:107907:1
position: 107907
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:107260-107907:1:exon

YEL024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RIP1
locus tag: YEL024W
product: ubiquinol--cytochrome-c reductase catalytic subunit RIP1
transcript id: NM_001178839.3
SIO_010081: YEL024W
subclass of: SO_0000673
so part of: YEL024W
location: <107260..>107907
location: region:107260-107907:1
so has part: feature:107260-107907:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:107260-107907:1:exon

YEL024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RIP1
locus tag: YEL024W
EC number: 7.1.1.8
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005750 mitochondrial respiratory chain complex III [PMID:10873857|PMID:3036836]
experiment: EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:3036836]
experiment: EXISTENCE:mutant phenotype:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:2537289]
experiment: EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3036836]
experiment: EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]
note: Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly
codon start: 1
product: ubiquinol--cytochrome-c reductase catalytic subunit RIP1
translation: MLGIRSSVKTCFKPMSLTSKRLISQSLLASKSTYRTPNFDDVLKENNDADKGRSYAYFMVGAMGLLSSAGAKSTVETFISSMTATADVLAMAKVEVNLAAIPLGKNVVVKWQGKPVFIRHRTPHEIQEANSVDMSALKDPQTDADRVKDPQWLIMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYEFDGDKVIVG
SIO_010081: YEL024W
subclass of: SO_0000673
so part of: YEL024W
location: 107260..107907
location: region:107260-107907:1
so has part: feature:107260-107907:1:exon

NP_010890.3
type: Protein
SIO_000068: ncbiprotein

S000000750
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:107260-107907:1:exon

YEL023C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL023C
so part of: sequence
location: complement(<108504..>110552)
location: region:108504-110552:-1
so has part: feature:108504-110552:-1:exon
subclass of: SO_0000010

856690
type: Gene
SIO_000068: ncbigene

position:108504:-1
position: 108504
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:110552:-1
position: 110552
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:108504-110552:-1:exon

YEL023C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL023C
product: uncharacterized protein
transcript id: NM_001178838.1
SIO_010081: YEL023C
subclass of: SO_0000673
so part of: YEL023C
location: complement(<108504..>110552)
location: region:108504-110552:-1
so has part: feature:108504-110552:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:108504-110552:-1:exon

YEL023C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL023C
note: hypothetical protein; expression is increased greatly during sporulation; YEL023C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MDSFNYIHGKYKKNGTGGDRSINPSSHSSSGKNIILCFDGTRENFGPQPFTNILKLYNLLENGDSSEQICYYQPGIGSVGFDAVVDVRRRLTISHLQNLLDSMFAFSLDNHICSAYLFLMKYFEPGDRIYMFGFSRGAFIARVLAGMIERVGLLSKGLEEMVKMAWQIYEKWEYDSQPNELQYTSTLAEEFKKTFSRDYEVKIHFQGLFDSVNSVGILRDRLFPCTQRSNIVEHVRHCVSLDERRGKFKQLCFTPMPYIPKLFSLTYCNHITDQCSPVPTSNALMRDLTPENPLIKYTLKSGAHSISNPSPLIPDNPGRLLSSKSEETTELLLDLNSFLEGNSYARDTECSTRGIEAIFQLQSIQGSGTSSRMTMTPDLIEKWFPGDHSDVGGGWAPDCETEENLSNLTLRWILAEAIKFGVKFKPGAIHDFATKHTSIGSLFADTHDYLSFNSPKKCSLLGVSDNEDGAREDKSGRNERMEDCLKNIKETRLSLKDEKEKVKDAFTLKCGHANKFMRLVWWVLELLPIGIRMENKEGKWQNFHTPNLGRSRYVPEYVSLHWSVYWRIKFDRRYRPDNMPEYVRQLFQDLEGIDLKSNKVSNKYDKQDNSNGSEINGGFFDNEEGQELHMGQKASYFATTYNSRLFDSKYSQLKKKFMDWDSNSWTDIPDDLKIYLQQDESL
SIO_010081: YEL023C
subclass of: SO_0000673
so part of: YEL023C
location: complement(108504..110552)
location: region:108504-110552:-1
so has part: feature:108504-110552:-1:exon

NP_010891.1
type: Protein
SIO_000068: ncbiprotein

S000000749
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:108504-110552:-1:exon

YEL022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GEA2
locus tag: YEL022W
so part of: sequence
location: <111421..>115800
location: region:111421-115800:1
so has part: feature:111421-115800:1:exon
subclass of: SO_0000010

856691
type: Gene
SIO_000068: ncbigene

position:111421:1
position: 111421
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:115800:1
position: 115800
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:111421-115800:1:exon

YEL022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GEA2
locus tag: YEL022W
product: Arf family guanine nucleotide exchange factor GEA2
transcript id: NM_001178837.1
SIO_010081: YEL022W
subclass of: SO_0000673
so part of: YEL022W
location: <111421..>115800
location: region:111421-115800:1
so has part: feature:111421-115800:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:111421-115800:1:exon

YEL022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GEA2
locus tag: YEL022W
experiment: EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:11294905]
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11294905]
experiment: EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:14668359]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11493664]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11493664]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]
experiment: EXISTENCE:mutant phenotype:GO:0033363 secretory granule organization [PMID:14734650]
note: Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
codon start: 1
product: Arf family guanine nucleotide exchange factor GEA2
translation: MSDREFVTVDPVTIIIKECINLSTAMRKYSKFTSQSGVAALLGGGSEIFSNQDDYLAHTFNNLNTNKHNDPFLSGFIQLRLMLNKLKNLDNIDSLTILQPFLLIVSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGAHRATVNALTHCRFEGSQQLSDDSVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTMIAVTVKIFSKLKTIEPVNVNQIYINDESYTNDVLKADTIGTNVESKEEGSQEDPIGMKVNNEEAISEDDGIEEEHIHSEKSTNGAEQLDIVQKTTRSNSRIQAYADDNYGLPVVRQYLNLLLSLIAPENELKHSYSTRIFGLELIQTALEISGDRLQLYPRLFTLISDPIFKSILFIIQNTTKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIKELLIEQISILWTRSPSFFTSTFINFDCNLDRADVSINFLKALTKLALPESALTTTESVPPICLEGLVSLVDDMFDHMKDIDREEFGRQKNEMEILKKRDRKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHGNEKWFEDAWNNLISSTTVITEIKKDTQSVMDKLTPLELLNFDRAIFKQVGPSIVSTLFNIYVVASDDHISTRMITSLDKCSYISAFFDFKDLFNDILNSIAKGTTLINSSHDDELSTLAFEYGPMPLVQIKFEDTNTEIPVSTDAVRFGRSFKGQLNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQKRLKLSNLPKPSPEISINKSKESKGLLSTFASYLKGDEEPTEEEIKSSKKAMECIKSSNIAASVFGNESNITADLIKTLLDSAKTEKNADNSRYFEAELLFIIELTIALFLFCKEEKELGKFILQKVFQLSHTKGLTKRTVRRMLTYKILLISLCADQTEYLSKLINDELLKKGDIFTQKFFATNQGKEFLKRLFSLTESEFYRGFLLGNENFWKFLRKVTAMKEQSESIFEYLNESIKTDSNILTNENFMWVLGLLDEISSMGAVGNHWEIEYKKLTESGHKIDKENPYKKSIELSLKSIQLTSHLLEDNNDLRKNEIFAIIQALAHQCINPCKQISEFAVVTLEQTLINKIEIPTNEMESVEELIEGGLLPLLNSSETQEDQKILISSILTIISNVYLHYLKLGKTSNETFLKILSIFNKFVEDSDIEKKLQQLILDKKSIEKGNGSSSHGSAHEQTPESNDVEIEATAPIDDNTDDDNKPKLSDVEKD
SIO_010081: YEL022W
subclass of: SO_0000673
so part of: YEL022W
location: 111421..115800
location: region:111421-115800:1
so has part: feature:111421-115800:1:exon

NP_010892.1
type: Protein
SIO_000068: ncbiprotein

S000000748
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:111421-115800:1:exon

YEL021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: URA3
locus tag: YEL021W
so part of: sequence
location: <116167..>116970
location: region:116167-116970:1
so has part: feature:116167-116970:1:exon
subclass of: SO_0000010

856692
type: Gene
SIO_000068: ncbigene

position:116167:1
position: 116167
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:116970:1
position: 116970
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:116167-116970:1:exon

YEL021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: URA3
locus tag: YEL021W
product: orotidine-5'-phosphate decarboxylase
transcript id: NM_001178836.3
SIO_010081: YEL021W
subclass of: SO_0000673
so part of: YEL021W
location: <116167..>116970
location: region:116167-116970:1
so has part: feature:116167-116970:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:116167-116970:1:exon

YEL021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: URA3
locus tag: YEL021W
EC number: 4.1.1.23
experiment: EXISTENCE:direct assay:GO:0004590 orotidine-5'-phosphate decarboxylase activity [PMID:2061334]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18812321]
experiment: EXISTENCE:direct assay:GO:0006222 UMP biosynthetic process [PMID:2061334]
experiment: EXISTENCE:mutant phenotype:GO:0004590 orotidine-5'-phosphate decarboxylase activity [PMID:5651325|PMID:4550660]
experiment: EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:5651325|PMID:4550660]
experiment: EXISTENCE:mutant phenotype:GO:0006222 UMP biosynthetic process [PMID:4550660|PMID:5651325]
note: Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
codon start: 1
product: orotidine-5'-phosphate decarboxylase
translation: MSKATYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELLELVEALGPKICLLKTHVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQYSAGVYRIAEWADITNAHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELSCKGSLATGEYTKGTVDIAKSDKDFVIGFIAQRDMGGRDEGYDWLIMTPGVGLDDKGDALGQQYRTVDDVVSTGSDIIIVGRGLFAKGRDAKVEGERYRKAGWEAYLRRCGQQN
SIO_010081: YEL021W
subclass of: SO_0000673
so part of: YEL021W
location: 116167..116970
location: region:116167-116970:1
so has part: feature:116167-116970:1:exon

NP_010893.3
type: Protein
SIO_000068: ncbiprotein

S000000747
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:116167-116970:1:exon

YEL020W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TIM9
locus tag: YEL020W-A
so part of: sequence
location: <117211..>117474
location: region:117211-117474:1
so has part: feature:117211-117474:1:exon
subclass of: SO_0000010

856693
type: Gene
SIO_000068: ncbigene

position:117211:1
position: 117211
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:117474:1
position: 117474
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117211-117474:1:exon

YEL020W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TIM9
locus tag: YEL020W-A
product: protein transporter TIM9
transcript id: NM_001184349.1
SIO_010081: YEL020W-A
subclass of: SO_0000673
so part of: YEL020W-A
location: <117211..>117474
location: region:117211-117474:1
so has part: feature:117211-117474:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:117211-117474:1:exon

YEL020W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TIM9
locus tag: YEL020W-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:9889188|PMID:9822593]
experiment: EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:9495346]
experiment: EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10469659|PMID:9822593]
experiment: EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12138093]
experiment: EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:9822593]
experiment: EXISTENCE:genetic interaction:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9822593]
experiment: EXISTENCE:genetic interaction:GO:0140318 protein transporter activity [PMID:9822593]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9889188]
note: Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
codon start: 1
product: protein transporter TIM9
translation: MDALNSKEQQEFQKVVEQKQMKDFMRLYSNLVERCFTDCVNDFTTSKLTNKEQTCIMKCSEKFLKHSERVGQRFQEQNAALGQGLGR
SIO_010081: YEL020W-A
subclass of: SO_0000673
so part of: YEL020W-A
location: 117211..117474
location: region:117211-117474:1
so has part: feature:117211-117474:1:exon

NP_010894.1
type: Protein
SIO_000068: ncbiprotein

S000007256
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117211-117474:1:exon

YNCE0007C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPR1
locus tag: YNCE0007C
so part of: sequence
location: complement(117667..118035)
location: region:117667-118035:-1
so has part: feature:117667-118035:-1:exon
subclass of: SO_0000011

9164884
type: Gene
SIO_000068: ncbigene

position:117667:-1
position: 117667
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:118035:-1
position: 118035
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:117667-118035:-1:exon

YNCE0007C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: RNase_P_RNA
gene: RPR1
locus tag: YNCE0007C
product: RPR1
experiment: EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:19095620|PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:19095620|PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0008033 tRNA processing [PMID:9620854]
experiment: EXISTENCE:direct assay:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
experiment: EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:1990278]
experiment: EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:1990278]
experiment: EXISTENCE:mutant phenotype:GO:0034965 intronic box C/D RNA processing [PMID:18713869]
note: RNA component of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; may be responsible for recognition of substrate tRNAs
transcript id: NR_132166.1
SIO_010081: YNCE0007C
subclass of: SO_0000673
so part of: YNCE0007C
location: complement(117667..118035)
location: region:117667-118035:-1
so has part: feature:117667-118035:-1:exon

S000006490
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:117667-118035:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(118230..118551)
location: region:118230-118551:-1
so has part: feature:118230-118551:-1:region

S000006888
type: SGD
SIO_000068: sgd

position:118230:-1
position: 118230
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:118551:-1
position: 118551
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118230-118551:-1:region

YEL020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PXP1
locus tag: YEL020C
so part of: sequence
location: complement(<118617..>120299)
location: region:118617-120299:-1
so has part: feature:118617-120299:-1:exon
subclass of: SO_0000010

856694
type: Gene
SIO_000068: ncbigene

position:118617:-1
position: 118617
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:120299:-1
position: 120299
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:118617-120299:-1:exon

YEL020C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PXP1
locus tag: YEL020C
product: putative indolepyruvate decarboxylase family protein
transcript id: NM_001178835.1
SIO_010081: YEL020C
subclass of: SO_0000673
so part of: YEL020C
location: complement(<118617..>120299)
location: region:118617-120299:-1
so has part: feature:118617-120299:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:118617-120299:-1:exon

YEL020C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PXP1
locus tag: YEL020C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27392156|PMID:26928762]
note: Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data
codon start: 1
product: putative indolepyruvate decarboxylase family protein
translation: MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEGNDRTGNELPMILTPNICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMAKGIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLGDNNVSPGADLSIWGDIGLSVTALVEELTRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGIYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRTKRETSVINVIIEPGEQKQIAFAWQNKPRL
SIO_010081: YEL020C
subclass of: SO_0000673
so part of: YEL020C
location: complement(118617..120299)
location: region:118617-120299:-1
so has part: feature:118617-120299:-1:exon

NP_010895.1
type: Protein
SIO_000068: ncbiprotein

S000000746
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:118617-120299:-1:exon

YEL019C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSE2
alternative label: PSO10
gene: MMS21
locus tag: YEL019C
gene synonym: NSE2; PSO10
so part of: sequence
location: complement(<120498..>121301)
location: region:120498-121301:-1
so has part: feature:120498-121301:-1:exon
subclass of: SO_0000010

856695
type: Gene
SIO_000068: ncbigene

position:120498:-1
position: 120498
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:121301:-1
position: 121301
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:120498-121301:-1:exon

YEL019C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSE2
alternative label: PSO10
gene: MMS21
locus tag: YEL019C
gene synonym: NSE2; PSO10
product: SUMO ligase MMS21
transcript id: NM_001178834.3
SIO_010081: YEL019C
subclass of: SO_0000673
so part of: YEL019C
location: complement(<120498..>121301)
location: region:120498-121301:-1
so has part: feature:120498-121301:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:120498-121301:-1:exon

YEL019C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSE2
alternative label: PSO10
gene: MMS21
locus tag: YEL019C
gene synonym: NSE2; PSO10
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391|PMID:31765407]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391|PMID:7788712]
experiment: EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:15738391|PMID:24108357|PMID:31765407]
experiment: EXISTENCE:mutant phenotype:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:24108357]
experiment: EXISTENCE:mutant phenotype:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]
note: Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function
codon start: 1
product: SUMO ligase MMS21
translation: MALNDNPIPKSVPLHPKSGKYFHNLHARDLSNIYQQCYKQIDETINQLVDSTSPSTIGIEEQVADITSTYKLLSTYESESNSFDEHIKDLKKNFKQSSDACPQIDLSTWDKYRTGELTAPKLSELYLNMPTPEPATMVNNTDTLKILKVLPYIWNDPTCVIPDLQNPADEDDLQIEGGKIELTCPITCKPYEAPLISRKCNHVFDRDGIQNYLQGYTTRDCPQAACSQVVSMRDFVRDPIMELRCKIAKMKESQEQDKRSSQAIDVL
SIO_010081: YEL019C
subclass of: SO_0000673
so part of: YEL019C
location: complement(120498..121301)
location: region:120498-121301:-1
so has part: feature:120498-121301:-1:exon

NP_010896.3
type: Protein
SIO_000068: ncbiprotein

S000000745
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:120498-121301:-1:exon

YEL018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EAF5
locus tag: YEL018W
so part of: sequence
location: <121471..>122310
location: region:121471-122310:1
so has part: feature:121471-122310:1:exon
subclass of: SO_0000010

856696
type: Gene
SIO_000068: ncbigene

position:121471:1
position: 121471
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:122310:1
position: 122310
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:121471-122310:1:exon

YEL018W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EAF5
locus tag: YEL018W
product: Eaf5p
transcript id: NM_001178833.1
SIO_010081: YEL018W
subclass of: SO_0000673
so part of: YEL018W
location: <121471..>122310
location: region:121471-122310:1
so has part: feature:121471-122310:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:121471-122310:1:exon

YEL018W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EAF5
locus tag: YEL018W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]
experiment: EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]
note: Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia
codon start: 1
product: Eaf5p
translation: MDKEVSELVVLQLIHTLISNKNEELVRNGGGINMIGNNLRISLVKLTNEIQNNLLINELTNLRRQSNVANGNRKLGINDILTIVKNLFPEYRTTLNDGQLSLHGLEMHDIEKLLDEKYDRFKKTQVEQIRMMEDEILKNGIKTGASQLQPHANAGKSGSAGTSATITTTTPHMAHSMDPKREKLLKLYRDTVLNKLESKTGNFQKLFKSPDGSIIKNEINYEDIKNETPGSVHELQLILQKSITDGVMRKVIGTDDWKLARQVQFELDDTVQFMRRALE
SIO_010081: YEL018W
subclass of: SO_0000673
so part of: YEL018W
location: 121471..122310
location: region:121471-122310:1
so has part: feature:121471-122310:1:exon

NP_010897.1
type: Protein
SIO_000068: ncbiprotein

S000000744
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:121471-122310:1:exon

YEL017C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMP2
locus tag: YEL017C-A
so part of: sequence
location: complement(<122798..>122929)
location: region:122798-122929:-1
so has part: feature:122798-122929:-1:exon
subclass of: SO_0000010

856697
type: Gene
SIO_000068: ncbigene

position:122798:-1
position: 122798
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:122929:-1
position: 122929
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:122798-122929:-1:exon

YEL017C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMP2
locus tag: YEL017C-A
product: proteolipid ATPase
transcript id: NM_001180029.1
SIO_010081: YEL017C-A
subclass of: SO_0000673
so part of: YEL017C-A
location: complement(<122798..>122929)
location: region:122798-122929:-1
so has part: feature:122798-122929:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:122798-122929:-1:exon

YEL017C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMP2
locus tag: YEL017C-A
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:8063750]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8063750]
experiment: EXISTENCE:genetic interaction:GO:0032781 positive regulation of ATP-dependent activity [PMID:8063750]
note: Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
codon start: 1
product: proteolipid ATPase
translation: MLMSTLPGGVILVFILVGLACIAIISTIIYRKWQARQRGLQRF
SIO_010081: YEL017C-A
subclass of: SO_0000673
so part of: YEL017C-A
location: complement(122798..122929)
location: region:122798-122929:-1
so has part: feature:122798-122929:-1:exon

NP_010898.1
type: Protein
SIO_000068: ncbiprotein

S000002103
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:122798-122929:-1:exon

YEL017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GTT3
locus tag: YEL017W
so part of: sequence
location: <123657..>124670
location: region:123657-124670:1
so has part: feature:123657-124670:1:exon
subclass of: SO_0000010

856698
type: Gene
SIO_000068: ncbigene

position:123657:1
position: 123657
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:124670:1
position: 124670
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:123657-124670:1:exon

YEL017W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GTT3
locus tag: YEL017W
product: Gtt3p
transcript id: NM_001178832.3
SIO_010081: YEL017W
subclass of: SO_0000673
so part of: YEL017W
location: <123657..>124670
location: region:123657-124670:1
so has part: feature:123657-124670:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:123657-124670:1:exon

YEL017W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GTT3
locus tag: YEL017W
experiment: EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]
note: hypothetical protein may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery
codon start: 1
product: Gtt3p
translation: MPTKSTFSRWKKADLIDLANKLEIDGFPNYAKKSDMIDYLESHLNHLEKPVDFKDDYPELRSFYESMTVDQSKDERNEYGSGSGNGSGSGSCDTATNDSDLEKAYIKEDDDEKPQSGDETSATKPLSSRNANSNAKTNFNLLDFSTDNDSSTSAFTKFKFNFQEYLSDIRYQTQKLNENVQDYLSTISAVDTIFSLLEFSFLVRNILAAGQPTSSSSLASSLEAAVAAHNKYQYTLDFCLPILTWLLFFRGIPTLVSYYINFIRYDLNIELDPMTFNLTKFLISLAIFKTCNNKNIDFHSFRCVNQLWTQLCTVNRSLGMVPLVFSMVSCLLTLYVL
SIO_010081: YEL017W
subclass of: SO_0000673
so part of: YEL017W
location: 123657..124670
location: region:123657-124670:1
so has part: feature:123657-124670:1:exon

NP_010899.3
type: Protein
SIO_000068: ncbiprotein

S000000743
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:123657-124670:1:exon

YEL016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NPP2
locus tag: YEL016C
so part of: sequence
location: complement(<124737..>126218)
location: region:124737-126218:-1
so has part: feature:124737-126218:-1:exon
subclass of: SO_0000010

856699
type: Gene
SIO_000068: ncbigene

position:124737:-1
position: 124737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:126218:-1
position: 126218
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:124737-126218:-1:exon

YEL016C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NPP2
locus tag: YEL016C
product: nucleotide diphosphatase/phosphodiesterase NPP2
transcript id: NM_001178831.1
SIO_010081: YEL016C
subclass of: SO_0000673
so part of: YEL016C
location: complement(<124737..>126218)
location: region:124737-126218:-1
so has part: feature:124737-126218:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:124737-126218:-1:exon

YEL016C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NPP2
locus tag: YEL016C
EC number: 3.1.4.1
EC number: 3.6.1.9
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]
experiment: EXISTENCE:genetic interaction:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]
experiment: EXISTENCE:genetic interaction:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]
experiment: EXISTENCE:mutant phenotype:GO:0009141 nucleoside triphosphate metabolic process [PMID:16278456]
experiment: EXISTENCE:mutant phenotype:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]
experiment: EXISTENCE:mutant phenotype:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]
note: Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants
codon start: 1
product: nucleotide diphosphatase/phosphodiesterase NPP2
translation: MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLLYSKCPKPIDNGPRTIANRSNTYFNGTHDFKTLTILISIDGFHPRLIDAKYTPFLYNLHNLRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFWDNFTSSEFRPNNLDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQWEKLQDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDGFFLDLIEGLQKRNLLKISNVMIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLYNEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEISRKFHVILKEDFDPSWKYFQYDNRKHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIGMGPMFNNEVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ
SIO_010081: YEL016C
subclass of: SO_0000673
so part of: YEL016C
location: complement(124737..126218)
location: region:124737-126218:-1
so has part: feature:124737-126218:-1:exon

NP_010900.1
type: Protein
SIO_000068: ncbiprotein

S000000742
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:124737-126218:-1:exon

YEL015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DCP3
alternative label: LSM16
gene: EDC3
locus tag: YEL015W
gene synonym: DCP3; LSM16
so part of: sequence
location: <126629..>128284
location: region:126629-128284:1
so has part: feature:126629-128284:1:exon
subclass of: SO_0000010

856700
type: Gene
SIO_000068: ncbigene

position:126629:1
position: 126629
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:128284:1
position: 128284
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:126629-128284:1:exon

YEL015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DCP3
alternative label: LSM16
gene: EDC3
locus tag: YEL015W
gene synonym: DCP3; LSM16
product: Edc3p
transcript id: NM_001178830.1
SIO_010081: YEL015W
subclass of: SO_0000673
so part of: YEL015W
location: <126629..>128284
location: region:126629-128284:1
so has part: feature:126629-128284:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:126629-128284:1:exon

YEL015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DCP3
alternative label: LSM16
gene: EDC3
locus tag: YEL015W
gene synonym: DCP3; LSM16
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:15020463]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:24492965]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:22842922]
experiment: EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:18981231]
experiment: EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15225544]
experiment: EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:17984320|PMID:18981231]
experiment: EXISTENCE:mutant phenotype:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:23956223|PMID:24492965]
note: Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: Edc3p
translation: MSQFVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQAFKVRASRLKDLKVLTVASQSGKRKQQRQQQQQNDYNQNRGEHIDWQDDDVSKIKQQEDFDFQRNLGMFNKKDVFAQLKQNDDILPENRLQGHNRKQTQLQQNNYQNDELVIPDAKKDSWNKISSRNEQSTHQSQPQQDAQDDLVLEDDEHEYDVDDIDDPKYLPITQSLNITHLIHSATNSPSINDKTKGTVINDKDQVLAKLGQMIISQSRSNSTSLPAANKQTTIRSKNTKQNIPMATPVQLLEMESITSEFFSINSAGLLENFAVNASFFLKQKLGGRARLRLQNSNPEPLVVILASDSNRSGAKALALGRHLCQTGHIRVITLFTCSQNELQDSMVKKQTDIYKKCGGKIVNSVSSLESAMETLNSPVEIVIDAMQGYDCTLSDLAGTSEVIESRIKSMISWCNKQRGSTKVWSLDIPNGFDAGSGMPDIFFSDRIEATGIICSGWPLIAINNLIANLPSLEDAVLIDIGIPQGAYSQRTSLRKFQNCDLFVTDGSLLLDL
SIO_010081: YEL015W
subclass of: SO_0000673
so part of: YEL015W
location: 126629..128284
location: region:126629-128284:1
so has part: feature:126629-128284:1:exon

NP_010901.1
type: Protein
SIO_000068: ncbiprotein

S000000741
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:126629-128284:1:exon

YEL014C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL014C
so part of: sequence
location: complement(<128303..>128608)
location: region:128303-128608:-1
so has part: feature:128303-128608:-1:exon
subclass of: SO_0000010

856701
type: Gene
SIO_000068: ncbigene

position:128303:-1
position: 128303
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:128608:-1
position: 128608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:128303-128608:-1:exon

YEL014C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL014C
product: uncharacterized protein
transcript id: NM_001348821.1
SIO_010081: YEL014C
subclass of: SO_0000673
so part of: YEL014C
location: complement(<128303..>128608)
location: region:128303-128608:-1
so has part: feature:128303-128608:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:128303-128608:-1:exon

YEL014C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL014C
note: hypothetical protein; conserved among S. cerevisiae strains
codon start: 1
product: uncharacterized protein
translation: MTALFCLELRTNIFLIMNDCIIINYWKGFIFSFHSYFFPFRFESSLRAHYPGKRNYSDFSVIPLPYYIDVRSFHICESQHIIALPLQIPLPYRMLIRMYPV
SIO_010081: YEL014C
subclass of: SO_0000673
so part of: YEL014C
location: complement(128303..128608)
location: region:128303-128608:-1
so has part: feature:128303-128608:-1:exon

NP_001335765.1
type: Protein
SIO_000068: ncbiprotein

S000000740
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:128303-128608:-1:exon

YEL013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YEB3
gene: VAC8
locus tag: YEL013W
gene synonym: YEB3
so part of: sequence
location: <128825..>130561
location: region:128825-130561:1
so has part: feature:128825-130561:1:exon
subclass of: SO_0000010

856702
type: Gene
SIO_000068: ncbigene

position:128825:1
position: 128825
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:130561:1
position: 130561
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:128825-130561:1:exon

YEL013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YEB3
gene: VAC8
locus tag: YEL013W
gene synonym: YEB3
product: protein anchor VAC8
transcript id: NM_001178828.3
SIO_010081: YEL013W
subclass of: SO_0000673
so part of: YEL013W
location: <128825..>130561
location: region:128825-130561:1
so has part: feature:128825-130561:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:128825-130561:1:exon

YEL013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YEB3
gene: VAC8
locus tag: YEL013W
gene synonym: YEB3
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16301533|PMID:9490720|PMID:9664035|PMID:9739084|PMID :26928762]
experiment: EXISTENCE:direct assay:GO:0000425 pexophagy [PMID:31262095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006914 autophagy [PMID:31262095]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0034517 ribophagy [PMID:31262095]
experiment: EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:10888680]
experiment: EXISTENCE:direct assay:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12529432]
experiment: EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:16301533|PMID:8885233|PMID:10888680]
experiment: EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:31649143]
experiment: EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:31649143]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:15901835]
experiment: EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:34893607]
experiment: EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:32508216|PMID:34893607]
experiment: EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:12529432|PMID:18701704]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:11441010|PMID:16301533]
experiment: EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:12594460]
experiment: EXISTENCE:mutant phenotype:GO:0051656 establishment of organelle localization [PMID:32508216]
experiment: EXISTENCE:mutant phenotype:GO:0071255 Cvt vesicle assembly [PMID:10837477]
experiment: EXISTENCE:mutant phenotype:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]
experiment: EXISTENCE:mutant phenotype:GO:1903044 protein localization to membrane raft [PMID:10888680]
experiment: EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:12594460]
experiment: EXISTENCE:physical interaction:GO:0071561 nucleus-vacuole junction [PMID:10888680]
experiment: EXISTENCE:physical interaction:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12529432|PMID:12594460]
note: Vacuole-specific Myo2p receptor; Myo2p-Vac17p-Vac8p transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-kinase complex I (PIK3C3-C1) to autophagosome; required with Atg13p for the vesicle closure step of the cytoplasm-to-vacuole (CVT) pathway, for homotypic vacuole-vacuole fusion and for nucleus-vacuole junction formation with Nvj1p; contains 11 armadillo (ARM) repeats; myristoylated, palmitoylated, and phosphorylated
codon start: 1
product: protein anchor VAC8
translation: MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYSGGPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVAACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKIATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDPDVQYYCTTALSNIAVDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASDTSYQLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVRLLDYKDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISACFAILALADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAWDRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMADVTFERLQRSGIDVKNPGSNNNPSSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQFLH
SIO_010081: YEL013W
subclass of: SO_0000673
so part of: YEL013W
location: 128825..130561
location: region:128825-130561:1
so has part: feature:128825-130561:1:exon

NP_010903.3
type: Protein
SIO_000068: ncbiprotein

S000000739
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:128825-130561:1:exon

YNCE0008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0008C
so part of: sequence
location: complement(131082..131153)
location: region:131082-131153:-1
so has part: feature:131082-131153:-1:exon
subclass of: SO_0000663

856703
type: Gene
SIO_000068: ncbigene

position:131082:-1
position: 131082
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:131153:-1
position: 131153
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131082-131153:-1:exon

YNCE0008C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0008C
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCE0008C
subclass of: SO_0000673
so part of: YNCE0008C
location: complement(131082..131153)
location: region:131082-131153:-1
so has part: feature:131082-131153:-1:exon

S000006697
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131082-131153:-1:exon

YEL012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GID3
gene: UBC8
locus tag: YEL012W
gene synonym: GID3
so part of: sequence
location: <131772..>132551
location: region:131772-132551:1
so has part: feature:131772-132551:1:exon
subclass of: SO_0000010

856704
type: Gene
SIO_000068: ncbigene

position:131772:1
position: 131772
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:132551:1
position: 132551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:131772-132551:1:exon

YEL012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GID3
gene: UBC8
locus tag: YEL012W
gene synonym: GID3
product: E2 ubiquitin-conjugating protein UBC8
transcript id: NM_001178827.1
SIO_010081: YEL012W
subclass of: SO_0000673
so part of: YEL012W
location: join(<131772..131776,131900..>132551)
location: region:131772-132551:1
so has part: feature:131772-131776:1:exon
so has part: feature:131900-132551:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:131772-131776:1:exon

position:131776:1
position: 131776
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:131900-132551:1:exon

position:131900:1
position: 131900
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YEL012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GID3
gene: UBC8
locus tag: YEL012W
gene synonym: GID3
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:1869573]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10811607]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10811607]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]
experiment: EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]
note: Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
codon start: 1
product: E2 ubiquitin-conjugating protein UBC8
translation: MSSSKRRIETDVMKLLMSDHQVDLINDSMQEFHVKFLGPKDTPYENGVWRLHVELPDNYPYKSPSIGFVNKIFHPNIDIASGSICLDVINSTWSPLYDLINIVEWMIPGLLKEPNGSDPLNNEAATLQLRDKKLYEEKIKEYIDKYATKEKYQQMFGGDNDSDDSDSGGDLQEEDSDSDEDMDGTGVSSGDDSVDELSEDLSDIDVSDDDDYDEVANQ
SIO_010081: YEL012W
subclass of: SO_0000673
so part of: YEL012W
location: join(131772..131776,131900..132551)
location: region:131772-132551:1
so has part: feature:131772-131776:1:exon
so has part: feature:131900-132551:1:exon

NP_010904.2
type: Protein
SIO_000068: ncbiprotein

S000000738
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:131772-131776:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:131900-132551:1:exon

YEL011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GHA1
gene: GLC3
locus tag: YEL011W
gene synonym: GHA1
so part of: sequence
location: <133120..>135234
location: region:133120-135234:1
so has part: feature:133120-135234:1:exon
subclass of: SO_0000010

856705
type: Gene
SIO_000068: ncbigene

position:133120:1
position: 133120
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:135234:1
position: 135234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:133120-135234:1:exon

YEL011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GHA1
gene: GLC3
locus tag: YEL011W
gene synonym: GHA1
product: 1,4-alpha-glucan branching enzyme
transcript id: NM_001178826.1
SIO_010081: YEL011W
subclass of: SO_0000673
so part of: YEL011W
location: <133120..>135234
location: region:133120-135234:1
so has part: feature:133120-135234:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:133120-135234:1:exon

YEL011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GHA1
gene: GLC3
locus tag: YEL011W
gene synonym: GHA1
EC number: 2.4.1.18
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0003844 1,4-alpha-glucan branching enzyme activity [PMID:1729600]
experiment: EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:1729600]
note: Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease
codon start: 1
product: 1,4-alpha-glucan branching enzyme
translation: MYNIPDNVKGAVEFDPWLKPFADVLSERRYLADKWLYDITHATPDGSYQSLSKFARDSYKSYGLHANPETKEITYKEWAPNAERAFLVGDFNNWDTTSHELKNKDEFGNFTITLHPLPNGDFAIPHDSKIKVMFILPDGSKIFRLPAWITRATQPSKETSKQFGPAYEGRFWNPENPYKFVHPRPKFSESVDSLRIYEAHVGISSPEPKITTYKEFTEKVLPRIKYLGYDAIQLMAIMEHAYYASFGYQVTNFFAASSRFGTPEELKELIDTAHSMGILVLLDVVHSHASKNVEDGLNMFDGSDHQYFHSISSGRGEHPLWDSRLFNYGKFEVQRFLLANLAFYVDVYQFDGFRFDGVTSMLYVHHGVGAGGSFSGDYNEYLSRDRSFVDHEALAYLMLANDLVHEMLPNLAVTVAEDVSGYPTLCLPRSIGGTGFDYRLAMALPDMWIKLIKEKKDDEWEMGSIVYTLTNRRYGEKVVAYCESHDQALVGDKTLAFWLMDAAMYTDMTVLKEPSIVIDRGIALHKMIRLITHSLGGEAYLNFEGNEFGHPEWLDFPNVNNGDSYKYARRQFNLADDPLLRYQNLNEFDRSMQLCEKRHKWLNTKQAYVSLKHEGDKMIVFERNNLLFIFNFHPTNSYSDYRVGVEKAGTYHIVLNSDRAEFGGHNRINESSEFFTTDLEWNNRKNFLQVYIPSRVALVLALKE
SIO_010081: YEL011W
subclass of: SO_0000673
so part of: YEL011W
location: 133120..135234
location: region:133120-135234:1
so has part: feature:133120-135234:1:exon

NP_010905.1
type: Protein
SIO_000068: ncbiprotein

S000000737
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:133120-135234:1:exon

YNCE0009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0009C
so part of: sequence
location: complement(135425..135497)
location: region:135425-135497:-1
so has part: feature:135425-135497:-1:exon
subclass of: SO_0000663

856706
type: Gene
SIO_000068: ncbigene

position:135425:-1
position: 135425
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:135497:-1
position: 135497
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135425-135497:-1:exon

YNCE0009C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0009C
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCE0009C
subclass of: SO_0000673
so part of: YNCE0009C
location: complement(135425..135497)
location: region:135425-135497:-1
so has part: feature:135425-135497:-1:exon

S000006618
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:135425-135497:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(135612..135939)
location: region:135612-135939:-1
so has part: feature:135612-135939:-1:region

S000006887
type: SGD
SIO_000068: sgd

position:135612:-1
position: 135612
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:135939:-1
position: 135939
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:135612-135939:-1:region

YEL009C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL009C-A
so part of: sequence
location: complement(<136371..>136778)
location: region:136371-136778:-1
so has part: feature:136371-136778:-1:exon
subclass of: SO_0000010

31009438
type: Gene
SIO_000068: ncbigene

position:136371:-1
position: 136371
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:136778:-1
position: 136778
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:136371-136778:-1:exon

YEL009C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL009C-A
product: uncharacterized protein
transcript id: NM_001348822.1
SIO_010081: YEL009C-A
subclass of: SO_0000673
so part of: YEL009C-A
location: complement(<136371..>136778)
location: region:136371-136778:-1
so has part: feature:136371-136778:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:136371-136778:-1:exon

YEL009C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL009C-A
note: hypothetical protein; conserved among S. cerevisiae strains; overlaps ORF YEL010W
codon start: 1
product: uncharacterized protein
translation: MNTLLKKYRKQRYAWLRFLLFSKIEGSLPVALRILLSLQPFCCNIYRKYYQENKKVKSTSGNTALKIIEKLESLVSNLRLKYSQMFSLLFLHSYNCLQSLATETFRIIKKREKNLLSLLIPGSCIEIARHFVLKE
SIO_010081: YEL009C-A
subclass of: SO_0000673
so part of: YEL009C-A
location: complement(136371..136778)
location: region:136371-136778:-1
so has part: feature:136371-136778:-1:exon

NP_001335766.1
type: Protein
SIO_000068: ncbiprotein

S000028741
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:136371-136778:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 137324..137639
location: region:137324-137639:1
so has part: feature:137324-137639:1:region

S000006891
type: SGD
SIO_000068: sgd

position:137324:1
position: 137324
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:137639:1
position: 137639
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:137324-137639:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 138221..138553
location: region:138221-138553:1
so has part: feature:138221-138553:1:region

S000006892
type: SGD
SIO_000068: sgd

position:138221:1
position: 138221
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:138553:1
position: 138553
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138221-138553:1:region

YNCE0010W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0010W
so part of: sequence
location: 138666..138737
location: region:138666-138737:1
so has part: feature:138666-138737:1:exon
subclass of: SO_0000663

856708
type: Gene
SIO_000068: ncbigene

position:138666:1
position: 138666
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:138737:1
position: 138737
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138666-138737:1:exon

YNCE0010W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0010W
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 11 nuclear tRNA genes containing the tDNA-anticodon UCU (converted to mcm5-UCU in the mature tRNA), decodes AGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCE0010W
subclass of: SO_0000673
so part of: YNCE0010W
location: 138666..138737
location: region:138666-138737:1
so has part: feature:138666-138737:1:exon

S000006710
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138666-138737:1:exon

YEL009C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AAS101
alternative label: AAS3
alternative label: ARG9
gene: GCN4
locus tag: YEL009C
gene synonym: AAS101; AAS3; ARG9
so part of: sequence
location: complement(<138918..>139763)
location: region:138918-139763:-1
so has part: feature:138918-139763:-1:exon
subclass of: SO_0000010

856709
type: Gene
SIO_000068: ncbigene

position:138918:-1
position: 138918
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:139763:-1
position: 139763
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:138918-139763:-1:exon

YEL009C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AAS101
alternative label: AAS3
alternative label: ARG9
gene: GCN4
locus tag: YEL009C
gene synonym: AAS101; AAS3; ARG9
product: amino acid starvation-responsive transcription factor GCN4
transcript id: NM_001178824.3
SIO_010081: YEL009C
subclass of: SO_0000673
so part of: YEL009C
location: complement(<138918..>139763)
location: region:138918-139763:-1
so has part: feature:138918-139763:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:138918-139763:-1:exon

YEL009C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AAS101
alternative label: AAS3
alternative label: ARG9
gene: GCN4
locus tag: YEL009C
gene synonym: AAS101; AAS3; ARG9
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19940160]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18794364]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:16581788]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12455686|PMID:14648200]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:2204805|PMID:3290651|PMID:3464968|PMID:3530496|PMID: 3907851|PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:18794364]
experiment: EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15121833]
experiment: EXISTENCE:genetic interaction:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:1425591]
experiment: EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15590823|PMID:26979516]
experiment: EXISTENCE:mutant phenotype:GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter [PMID:21148207]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16581788|PMID:19940160]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16581788]
experiment: EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]
experiment: EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:26649943]
experiment: EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:21183953]
experiment: EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15121833]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26649943]
experiment: EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:1425591]
experiment: EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]
experiment: EXISTENCE:mutant phenotype:GO:1990139 protein localization to nuclear periphery [PMID:31211995]
experiment: EXISTENCE:physical interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19940160]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326|PMID:21183953]
note: bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; contains four upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
codon start: 1
product: amino acid starvation-responsive transcription factor GCN4
translation: MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER
SIO_010081: YEL009C
subclass of: SO_0000673
so part of: YEL009C
location: complement(138918..139763)
location: region:138918-139763:-1
so has part: feature:138918-139763:-1:exon

NP_010907.3
type: Protein
SIO_000068: ncbiprotein

S000000735
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:138918-139763:-1:exon

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of four upstream open reading frames (uORFs) in 5' untranslated region of GCN4 gene, regulate translation
so part of: sequence
location: complement(139903..139914)
location: region:139903-139914:-1
so has part: feature:139903-139914:-1:region

position:139903:-1
position: 139903
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:139914:-1
position: 139914
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139903-139914:-1:region

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of four upstream open reading frames (uORFs) in 5' untranslated region of GCN4 gene, regulate translation
so part of: sequence
location: complement(139928..139939)
location: region:139928-139939:-1
so has part: feature:139928-139939:-1:region

position:139928:-1
position: 139928
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:139939:-1
position: 139939
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:139928-139939:-1:region

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of four upstream open reading frames (uORFs) in 5' untranslated region of GCN4 gene, regulate translation
so part of: sequence
location: complement(140048..140056)
location: region:140048-140056:-1
so has part: feature:140048-140056:-1:region

position:140048:-1
position: 140048
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:140056:-1
position: 140056
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140048-140056:-1:region

regulatory
type: Feature
subclass of: SO_0000001
RO_0002162: 559292
regulatory class: other
note: One of four upstream open reading frames (uORFs) in 5' untranslated region of GCN4 gene, regulate translation
so part of: sequence
location: complement(140113..140124)
location: region:140113-140124:-1
so has part: feature:140113-140124:-1:region

position:140113:-1
position: 140113
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:140124:-1
position: 140124
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140113-140124:-1:region

YEL008W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YEL008W
so part of: sequence
location: <140512..>140892
location: region:140512-140892:1
so has part: feature:140512-140892:1:exon
subclass of: SO_0000010

856710
type: Gene
SIO_000068: ncbigene

position:140512:1
position: 140512
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:140892:1
position: 140892
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:140512-140892:1:exon

YEL008W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YEL008W
product: uncharacterized protein
transcript id: NM_001348823.1
SIO_010081: YEL008W
subclass of: SO_0000673
so part of: YEL008W
location: <140512..>140892
location: region:140512-140892:1
so has part: feature:140512-140892:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:140512-140892:1:exon

YEL008W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YEL008W
note: hypothetical protein; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism
codon start: 1
product: uncharacterized protein
translation: MLMHFIPRRSSKAVQFNWLEIGVWRGGVYVKKGIVNARTNNSNFYKMPVVFGIVKGMGALCVHAWGMGYGGIIDCSPVTEHGNISVLQLEYMPWICLSKIMSCSVASRHSNVWIMDETIAPLVGCL
SIO_010081: YEL008W
subclass of: SO_0000673
so part of: YEL008W
location: 140512..140892
location: region:140512-140892:1
so has part: feature:140512-140892:1:exon

NP_001335767.1
type: Protein
SIO_000068: ncbiprotein

S000000734
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:140512-140892:1:exon

YEL007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIT1
locus tag: YEL007W
so part of: sequence
location: <141892..>143892
location: region:141892-143892:1
so has part: feature:141892-143892:1:exon
subclass of: SO_0000010

856711
type: Gene
SIO_000068: ncbigene

position:141892:1
position: 141892
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:143892:1
position: 143892
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:141892-143892:1:exon

YEL007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIT1
locus tag: YEL007W
product: Mit1p
transcript id: NM_001178822.1
SIO_010081: YEL007W
subclass of: SO_0000673
so part of: YEL007W
location: <141892..>143892
location: region:141892-143892:1
so has part: feature:141892-143892:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:141892-143892:1:exon

YEL007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIT1
locus tag: YEL007W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
codon start: 1
product: Mit1p
translation: MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLIVSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSAVITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKYTGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIVAMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSANKNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNSNNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDFINPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPTESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPYYNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYAMASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKNFAMGHANNNILNITNNDTMNNLNTNTSTTTQ
SIO_010081: YEL007W
subclass of: SO_0000673
so part of: YEL007W
location: 141892..143892
location: region:141892-143892:1
so has part: feature:141892-143892:1:exon

NP_010909.1
type: Protein
SIO_000068: ncbiprotein

S000000733
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:141892-143892:1:exon

YEL006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NDT2
gene: YEA6
locus tag: YEL006W
gene synonym: NDT2
so part of: sequence
location: <144327..>145334
location: region:144327-145334:1
so has part: feature:144327-145334:1:exon
subclass of: SO_0000010

856712
type: Gene
SIO_000068: ncbigene

position:144327:1
position: 144327
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:145334:1
position: 145334
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:144327-145334:1:exon

YEL006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NDT2
gene: YEA6
locus tag: YEL006W
gene synonym: NDT2
product: NAD+ transporter
transcript id: NM_001178821.1
SIO_010081: YEL006W
subclass of: SO_0000673
so part of: YEL006W
location: <144327..>145334
location: region:144327-145334:1
so has part: feature:144327-145334:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:144327-145334:1:exon

YEL006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NDT2
gene: YEA6
locus tag: YEL006W
gene synonym: NDT2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0035352 NAD transmembrane transport [PMID:16291748]
experiment: EXISTENCE:genetic interaction:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]
experiment: EXISTENCE:mutant phenotype:GO:0035352 NAD transmembrane transport [PMID:16291748]
experiment: EXISTENCE:mutant phenotype:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]
note: Mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YEA6 reciprocally complements defects in MCART1/SLC25A51 null cells
codon start: 1
product: NAD+ transporter
translation: MNNGDNKTTLENSKNASLANGNYAIPTKLNRLKKNADPRVAAISGALSGALSAMLVCPFDVAKTRLQAQGLQNMTHQSQHYKGFFGTFATIFKDEGAAGLYKGLQPTVLGYIPTLMIYFSVYDFCRKYSVDIFPHSPFLSNASSAITAGAISTVATNPIWVVKTRLMLQTGIGKYSTHYKGTIDTFRKIIQQEGAKALYAGLVPALLGMLNVAIQFPLYENLKIRFGYSESTDVSTDVTSSNFQKLILASMLSKMVASTVTYPHEILRTRMQLKSDLPNTVQRHLLPLIKITYRQEGFAGFYSGFATNLVRTVPAAVVTLVSFEYSKKYLTTFFQ
SIO_010081: YEL006W
subclass of: SO_0000673
so part of: YEL006W
location: 144327..145334
location: region:144327-145334:1
so has part: feature:144327-145334:1:exon

NP_010910.1
type: Protein
SIO_000068: ncbiprotein

S000000732
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:144327-145334:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS510; Autonomously Replicating Sequence
so part of: sequence
location: 145678..145840
location: region:145678-145840:1
so has part: feature:145678-145840:1:region

S000077382
type: SGD
SIO_000068: sgd

position:145678:1
position: 145678
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:145840:1
position: 145840
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145678-145840:1:region

YEL005C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VAB31
gene: VAB2
locus tag: YEL005C
gene synonym: VAB31
so part of: sequence
location: complement(<145907..>146755)
location: region:145907-146755:-1
so has part: feature:145907-146755:-1:exon
subclass of: SO_0000010

856713
type: Gene
SIO_000068: ncbigene

position:145907:-1
position: 145907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:146755:-1
position: 146755
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:145907-146755:-1:exon

YEL005C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VAB31
gene: VAB2
locus tag: YEL005C
gene synonym: VAB31
product: Vab2p
transcript id: NM_001178820.3
SIO_010081: YEL005C
subclass of: SO_0000673
so part of: YEL005C
location: complement(<145907..>146755)
location: region:145907-146755:-1
so has part: feature:145907-146755:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:145907-146755:-1:exon

YEL005C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VAB31
gene: VAB2
locus tag: YEL005C
gene synonym: VAB31
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]
note: Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern
codon start: 1
product: Vab2p
translation: MVADLTKGILKWKSRIEFDAVGSSSYYEELKGLPPLASHKKLTQAAIFNSTKYELLQVKKDILSIYEVVSRDIDEERNQMQQIELQLKKSLKKVEHSYKNVLKQRASTNCINGNDRLLANAEKKIGSLNEELACVNDIVSDIVNNLTALNANLPKKAQLLKDDSINVAHYPLLFDFLHKSCPKSIIATSEASIHENASPSPLLEHDELPAESINSFYGENELQSDSLAPLQTHDDNISSCKKILPPKFNTTSGPSIETNFENISADGLTYTKCSLKNSISLT
SIO_010081: YEL005C
subclass of: SO_0000673
so part of: YEL005C
location: complement(145907..146755)
location: region:145907-146755:-1
so has part: feature:145907-146755:-1:exon

NP_010911.3
type: Protein
SIO_000068: ncbiprotein

S000000731
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:145907-146755:-1:exon

YEL004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YEA4
locus tag: YEL004W
so part of: sequence
location: <146951..>147979
location: region:146951-147979:1
so has part: feature:146951-147979:1:exon
subclass of: SO_0000010

856714
type: Gene
SIO_000068: ncbigene

position:146951:1
position: 146951
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:147979:1
position: 147979
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:146951-147979:1:exon

YEL004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YEA4
locus tag: YEL004W
product: Yea4p
transcript id: NM_001178819.1
SIO_010081: YEL004W
subclass of: SO_0000673
so part of: YEL004W
location: <146951..>147979
location: region:146951-147979:1
so has part: feature:146951-147979:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:146951-147979:1:exon

YEL004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YEA4
locus tag: YEL004W
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10788474]
experiment: EXISTENCE:genetic interaction:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]
experiment: EXISTENCE:mutant phenotype:GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity [PMID:10788474]
experiment: EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]
experiment: EXISTENCE:mutant phenotype:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:10788474]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:10788474]
experiment: EXISTENCE:mutant phenotype:GO:1990569 UDP-N-acetylglucosamine transmembrane transport [PMID:10788474]
note: Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER
codon start: 1
product: Yea4p
translation: MWNSLKAFALVFGGCCSNVITFETLMSNETGSINNLITFCQFLFVTCQGLPEFLDVHQPFPYFKPLKTPLHVYVITVVLFYISSTTNNNVFKYNISIPIHIVFRCFGTVITMFTCWLLNGRKYTKIQILSTLFLTIGAIIASLFKDADFRYQDLKLQAWKIGSDQSVDLTFIFGICILVLSSFTSSLLSAYNERTYQKYGKHWKENIFYSHFLSLPLFLFSRKQLIHEYRVMRKSERILCSNFGGKILVPREETLLLFNVLTQYFCVKGVNILASKTNALTLSITLLVRKFISLLLSVRLFDNNLSYTGYIGVYLVFFGAFIYSLGSIHPRQNDKGAIKKSK
SIO_010081: YEL004W
subclass of: SO_0000673
so part of: YEL004W
location: 146951..147979
location: region:146951-147979:1
so has part: feature:146951-147979:1:exon

NP_010912.1
type: Protein
SIO_000068: ncbiprotein

S000000730
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:146951-147979:1:exon

YEL003W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PFD2
gene: GIM4
locus tag: YEL003W
gene synonym: PFD2
so part of: sequence
location: <148176..>148599
location: region:148176-148599:1
so has part: feature:148176-148599:1:exon
subclass of: SO_0000010

856715
type: Gene
SIO_000068: ncbigene

position:148176:1
position: 148176
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:148599:1
position: 148599
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148176-148599:1:exon

YEL003W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PFD2
gene: GIM4
locus tag: YEL003W
gene synonym: PFD2
product: tubulin-binding prefolding complex subunit GIM4
transcript id: NM_001178818.1
SIO_010081: YEL003W
subclass of: SO_0000673
so part of: YEL003W
location: join(<148176..148194,148283..>148599)
location: region:148176-148599:1
so has part: feature:148176-148194:1:exon
so has part: feature:148283-148599:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148176-148194:1:exon

position:148194:1
position: 148194
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:148283-148599:1:exon

position:148283:1
position: 148283
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YEL003W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PFD2
gene: GIM4
locus tag: YEL003W
gene synonym: PFD2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]
experiment: EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]
experiment: EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]
note: Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it
codon start: 1
product: tubulin-binding prefolding complex subunit GIM4
translation: MEQRNNVFQAKYNEYKQILEELQTKIIELGHDKDEHTIVIKTLKDAEPTRKCYRMIGGALVESDVQTSLPILETKKENIEGTISKMKETLIQTAKEFEKWKKDNKIQVVKN
SIO_010081: YEL003W
subclass of: SO_0000673
so part of: YEL003W
location: join(148176..148194,148283..148599)
location: region:148176-148599:1
so has part: feature:148176-148194:1:exon
so has part: feature:148283-148599:1:exon

NP_010913.2
type: Protein
SIO_000068: ncbiprotein

S000000729
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148176-148194:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:148283-148599:1:exon

YEL002C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: WBP1
locus tag: YEL002C
so part of: sequence
location: complement(<148722..>150014)
location: region:148722-150014:-1
so has part: feature:148722-150014:-1:exon
subclass of: SO_0000010

856716
type: Gene
SIO_000068: ncbigene

position:148722:-1
position: 148722
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150014:-1
position: 150014
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:148722-150014:-1:exon

YEL002C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: WBP1
locus tag: YEL002C
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
transcript id: NM_001178817.3
SIO_010081: YEL002C
subclass of: SO_0000673
so part of: YEL002C
location: complement(<148722..>150014)
location: region:148722-150014:-1
so has part: feature:148722-150014:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:148722-150014:-1:exon

YEL002C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: WBP1
locus tag: YEL002C
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:1724755]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12860997|PMID:1724755]
experiment: EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]
experiment: EXISTENCE:direct assay:GO:0016757 glycosyltransferase activity [PMID:1600939]
experiment: EXISTENCE:mutant phenotype:GO:0004576 oligosaccharyl transferase activity [PMID:1600939]
experiment: EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:12974639]
experiment: EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]
experiment: EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]
note: Non-catalytic beta subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes N-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Ost2p involved in binding terminal glucose units of the donor glycan; human homolog DDOST can complement yeast growth defect during down-regulation of the yeast gene
codon start: 1
product: dolichyl-diphosphooligosaccharide-protein glycotransferase
translation: MRTDWNFFFCILLQAIFVVGTQTSRTLVLYDQSTEPLEEYSVYLKDLEQRNYKLEYLDINSTSTTVDLYDKEQRLFDNIIVFPTKGGKNLARQIPVKQLIKFFENEGNILCMSSPGAVPNTIRLFLNELGIYPSPKGHVIRDYFSPSSEELVVSSNHLLNKYVYNARKSEDFVFGESSAALLENREQIVPILNAPRTSFTESKGKCNSWTSGSQGFLVVGFQNLNNARLVWIGSSDFLKNKNQDSNQEFAKELLKWTFNEKSVIKSVHAVHSHADGTSYDEEPYKIKDKVIYSVGFSEWNGEEWLPHIADDIQFELRQVDPYYRLTLSPSGNDSETQYYTTGEFILPDRHGVFTFLTDYRKIGLSFTTDKDVKAIRHLANDEYPRSWEISNSWVYISAICGVIVAWIFFVVSFVTTSSVGKKLETFKKTN
SIO_010081: YEL002C
subclass of: SO_0000673
so part of: YEL002C
location: complement(148722..150014)
location: region:148722-150014:-1
so has part: feature:148722-150014:-1:exon

NP_010914.3
type: Protein
SIO_000068: ncbiprotein

S000000728
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:148722-150014:-1:exon

YEL001C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IRC22
locus tag: YEL001C
so part of: sequence
location: complement(<150301..>150978)
location: region:150301-150978:-1
so has part: feature:150301-150978:-1:exon
subclass of: SO_0000010

856717
type: Gene
SIO_000068: ncbigene

position:150301:-1
position: 150301
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:150978:-1
position: 150978
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:150301-150978:-1:exon

YEL001C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IRC22
locus tag: YEL001C
product: Irc22p
transcript id: NM_001178816.1
SIO_010081: YEL001C
subclass of: SO_0000673
so part of: YEL001C
location: complement(<150301..>150978)
location: region:150301-150978:-1
so has part: feature:150301-150978:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:150301-150978:-1:exon

YEL001C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IRC22
locus tag: YEL001C
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:22842922|PMID:26928762]
note: hypothetical protein; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
codon start: 1
product: Irc22p
translation: MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSINIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYPVADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLFEIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPETYKK
SIO_010081: YEL001C
subclass of: SO_0000673
so part of: YEL001C
location: complement(150301..150978)
location: region:150301-150978:-1
so has part: feature:150301-150978:-1:exon

NP_010915.1
type: Protein
SIO_000068: ncbiprotein

S000000727
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:150301-150978:-1:exon

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN5; Chromosome V centromere
so part of: sequence
location: 151987..152104
location: region:151987-152104:1
so has part: feature:151987-152104:1:region

S000006467
type: SGD
SIO_000068: sgd

position:151987:1
position: 151987
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:152104:1
position: 152104
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151987-152104:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN5_CDEI of CEN5
so part of: sequence
location: 151987..151996
location: region:151987-151996:1
so has part: feature:151987-151996:1:region

position:151996:1
position: 151996
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151987-151996:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN5_CDEII of CEN5
so part of: sequence
location: 151997..152079
location: region:151997-152079:1
so has part: feature:151997-152079:1:region

position:151997:1
position: 151997
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:152079:1
position: 152079
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:151997-152079:1:region

centromere
type: Centromere
subclass of: SO_0000577
RO_0002162: 559292
note: CEN5_CDEIII of CEN5
so part of: sequence
location: 152080..152104
location: region:152080-152104:1
so has part: feature:152080-152104:1:region

position:152080:1
position: 152080
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:152080-152104:1:region

YER001W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MNN1
locus tag: YER001W
so part of: sequence
location: <153520..>155808
location: region:153520-155808:1
so has part: feature:153520-155808:1:exon
subclass of: SO_0000010

856718
type: Gene
SIO_000068: ncbigene

position:153520:1
position: 153520
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:155808:1
position: 155808
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:153520-155808:1:exon

YER001W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MNN1
locus tag: YER001W
product: alpha-1,3-mannosyltransferase MNN1
transcript id: NM_001178892.1
SIO_010081: YER001W
subclass of: SO_0000673
so part of: YER001W
location: <153520..>155808
location: region:153520-155808:1
so has part: feature:153520-155808:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:153520-155808:1:exon

YER001W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MNN1
locus tag: YER001W
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:7962051]
experiment: EXISTENCE:direct assay:GO:0006493 protein O-linked glycosylation [PMID:7962051]
experiment: EXISTENCE:mutant phenotype:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:8146181]
experiment: EXISTENCE:mutant phenotype:GO:0006491 N-glycan processing [PMID:8146181]
note: Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides; one of five S. cerevisiae proteins of MNN1 family; targeted to vacuole via AP-3 pathway
codon start: 1
product: alpha-1,3-mannosyltransferase MNN1
translation: MLALRRFILNQRSLRSCTIPILVGALIIILVLFQLVTHRNDALIRSSNVNSTNKKTLKDADPKVLIEAFGSPEVDPVDTIPVSPLELVPFYDQSIDTKRSSSWLINKKGYYKHFNELSLTDRCKFYFRTLYTLDDEWTNSVKKLEYSINDNEGVDEGKDANGNPMDEKSERLYRRKYDMFQAFERIRAYDRCFMQANPVNIQEIFPKSDKMSKERVQSKLIKTLNATFPNYDPDNFKKYDQFEFEHKMFPFINNFTTETFHEMVPKITSPFGKVLEQGFLPKFDHKTGKVQEYFKYEYDPSKTFWANWRDMSAKVAGRGIVLSLGSNQFPLAVKFIASLRFEGNTLPIQVVYRGDELSQELVDKLIYAARSPDFKPVENNYDNSTNVPQEIWFLDVSNTIHPKWRGDFGSYKSKWLVVLLNLLQEFVFLDIDAISYEKIDNYFKTTEYQKTGTVFYRERALRENVNERCIARYETLLPRNLESKNFQNSLLIDPDHALNECDNTLTTEEYIFKAFFHHRRQHQLEAGLFAVDKSKHTIPLVLAAMIHLAKNTAHCTHGDKENFWLGFLAAGHTYALQGVYSGAIGDYVKKTDLNGKRQEAAVEICSGQIAHMSTDKKTLLWVNGGGTFCKHDNAAKDDWKKDGDFKKFKDQFKTFEEMEKYYYITPISSKYVILPDPKSDDWHRASAGACGGYIWCATHKTLLKPYSYNHRTTHGELITLDEEQRLHIDAVNTVWSHANKDNTRSFTEEEIKELENSRHEQS
SIO_010081: YER001W
subclass of: SO_0000673
so part of: YER001W
location: 153520..155808
location: region:153520-155808:1
so has part: feature:153520-155808:1:exon

NP_010916.1
type: Protein
SIO_000068: ncbiprotein

S000000803
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:153520-155808:1:exon

YER002W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NOP16
locus tag: YER002W
so part of: sequence
location: <156803..>157498
location: region:156803-157498:1
so has part: feature:156803-157498:1:exon
subclass of: SO_0000010

856719
type: Gene
SIO_000068: ncbigene

position:156803:1
position: 156803
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:157498:1
position: 157498
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:156803-157498:1:exon

YER002W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NOP16
locus tag: YER002W
product: Nop16p
transcript id: NM_001178893.3
SIO_010081: YER002W
subclass of: SO_0000673
so part of: YER002W
location: <156803..>157498
location: region:156803-157498:1
so has part: feature:156803-157498:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:156803-157498:1:exon

YER002W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NOP16
locus tag: YER002W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
note: Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis
codon start: 1
product: Nop16p
translation: MTSVRKRKMNRSSVGKATRRNKDKQRKINIQSNPIIAANWDYSLTMAQNYKKLGLRAKLQTPAGGKEADLSKVVKRIPLTKPVLDEDEDEDEGEDEQNDYNAATVELDENEIPEGGARIQRDKNGDVVRVVYGKKKNFDADEDVNEIKARDTTEETEVVKKLEELASRPVIRKERSQSEREEEWLEKLYKKHGDDYKKMFFDKKLNIYQQSEGDLKRRLLRWKKRNGIASK
SIO_010081: YER002W
subclass of: SO_0000673
so part of: YER002W
location: 156803..157498
location: region:156803-157498:1
so has part: feature:156803-157498:1:exon

NP_010917.3
type: Protein
SIO_000068: ncbiprotein

S000000804
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:156803-157498:1:exon

YER003C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMI40
locus tag: YER003C
so part of: sequence
location: complement(<157736..>159118)
location: region:157736-159118:-1
so has part: feature:157736-159118:-1:exon
subclass of: SO_0000010

856720
type: Gene
SIO_000068: ncbigene

position:157736:-1
position: 157736
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:159118:-1
position: 159118
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:157736-159118:-1:exon

YER003C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMI40
locus tag: YER003C
product: mannose-6-phosphate isomerase PMI40
transcript id: NM_001178894.1
SIO_010081: YER003C
subclass of: SO_0000673
so part of: YER003C
location: complement(join(<157736..158994,159088..>159118))
location: region:157736-159118:-1
so has part: feature:159088-159118:-1:exon
so has part: feature:157736-158994:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159088-159118:-1:exon

position:159088:-1
position: 159088
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:157736-158994:-1:exon

position:158994:-1
position: 158994
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER003C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMI40
locus tag: YER003C
EC number: 5.3.1.8
experiment: EXISTENCE:direct assay:GO:0004476 mannose-6-phosphate isomerase activity [PMID:8011630]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:1377774]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:1377774]
experiment: EXISTENCE:mutant phenotype:GO:0009298 GDP-mannose biosynthetic process [PMID:1377774]
note: Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
codon start: 1
product: mannose-6-phosphate isomerase PMI40
translation: MSNKLFRLDAGYQQYDWGKIGSSSAVAQFAAHSDPSVQIEQDKPYAELWMGTHSKMPSYNHESKESLRDIISKNPSAMLGKDIIDKFHATNELPFLFKVLSIEKVLSIQAHPDKALGKILHAQDPKNYPDDNHKPEMAIAVTDFEGFCGFKPLQEIADELKRIPELRNIVGEETSRNFIENIQPSAQKGSPEDEQNKKLLQAVFSRVMNASDDKIKIQARSLVERSKNSPSDFNKPDLPELIQRLNKQFPDDVGLFCGCLLLNHCRLNAGEAIFLRAKDPHAYISGDIMECMAASDNVVRAGFTPKFKDVKNLVSMLTYTYDPVEKQKMQPLKFDRSSGNGKSVLYNPPIEEFAVLETTFDEKLGQRHFEGVDGPSILITTKGNGYIKADGQKLKAEPGFVFFIAPHLPVDLEAEDEAFTTYRAFVEPN
SIO_010081: YER003C
subclass of: SO_0000673
so part of: YER003C
location: complement(join(157736..158994,159088..159118))
location: region:157736-159118:-1
so has part: feature:159088-159118:-1:exon
so has part: feature:157736-158994:-1:exon

NP_010918.1
type: Protein
SIO_000068: ncbiprotein

S000000805
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159088-159118:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:157736-158994:-1:exon

YER004W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP52
locus tag: YER004W
so part of: sequence
location: <159580..>160275
location: region:159580-160275:1
so has part: feature:159580-160275:1:exon
subclass of: SO_0000010

856721
type: Gene
SIO_000068: ncbigene

position:159580:1
position: 159580
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:160275:1
position: 160275
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:159580-160275:1:exon

YER004W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP52
locus tag: YER004W
product: Fmp52p
transcript id: NM_001178895.1
SIO_010081: YER004W
subclass of: SO_0000673
so part of: YER004W
location: <159580..>160275
location: region:159580-160275:1
so has part: feature:159580-160275:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:159580-160275:1:exon

YER004W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP52
locus tag: YER004W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
note: hypothetical protein; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
codon start: 1
product: Fmp52p
translation: MNGLVLGATGLCGGGFLRHAQEAPQFSKVYAILRRELPFPATDKVVAIVERDNSKWSQLITNEMNPQVLFTALATTRAAAGGLDKQYKIDHDLNLQLAQAAKEKGCETIVLVSSAGAHPDSRFGYMKMKGEIERDVIALDFKHIIILRPGPLLGERTNSKQSGFGGNLTAALGTRVYRSRFQRLLGYPVYGDEVGKVGVHLALNTSGKDKVQFVSSKDILDISASLEKIAT
SIO_010081: YER004W
subclass of: SO_0000673
so part of: YER004W
location: 159580..160275
location: region:159580-160275:1
so has part: feature:159580-160275:1:exon

NP_010919.1
type: Protein
SIO_000068: ncbiprotein

S000000806
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:159580-160275:1:exon

YER005W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APY1
alternative label: YEJ5
gene: YND1
locus tag: YER005W
gene synonym: APY1; YEJ5
so part of: sequence
location: <160550..>162442
location: region:160550-162442:1
so has part: feature:160550-162442:1:exon
subclass of: SO_0000010

856722
type: Gene
SIO_000068: ncbigene

position:160550:1
position: 160550
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:162442:1
position: 162442
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:160550-162442:1:exon

YER005W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APY1
alternative label: YEJ5
gene: YND1
locus tag: YER005W
gene synonym: APY1; YEJ5
product: apyrase
transcript id: NM_001178896.3
SIO_010081: YER005W
subclass of: SO_0000673
so part of: YER005W
location: <160550..>162442
location: region:160550-162442:1
so has part: feature:160550-162442:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:160550-162442:1:exon

YER005W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APY1
alternative label: YEJ5
gene: YND1
locus tag: YER005W
gene synonym: APY1; YEJ5
EC number: 3.6.1.5
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10551827]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:10409709]
experiment: EXISTENCE:direct assay:GO:0017110 nucleoside diphosphate phosphatase activity [PMID:10409709]
experiment: EXISTENCE:direct assay:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:10409709]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:10409709]
note: Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
codon start: 1
product: apyrase
translation: MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSILQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFIQATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYLYGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQKWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDFEFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSEYWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKGNWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGNDDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIFHRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMKSSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD
SIO_010081: YER005W
subclass of: SO_0000673
so part of: YER005W
location: 160550..162442
location: region:160550-162442:1
so has part: feature:160550-162442:1:exon

NP_010920.3
type: Protein
SIO_000068: ncbiprotein

S000000807
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:160550-162442:1:exon

YER006W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUG1
locus tag: YER006W
so part of: sequence
location: <162723..>164285
location: region:162723-164285:1
so has part: feature:162723-164285:1:exon
subclass of: SO_0000010

856723
type: Gene
SIO_000068: ncbigene

position:162723:1
position: 162723
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:164285:1
position: 164285
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:162723-164285:1:exon

YER006W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUG1
locus tag: YER006W
product: RNA-binding GTPase NUG1
transcript id: NM_001178897.1
SIO_010081: YER006W
subclass of: SO_0000673
so part of: YER006W
location: <162723..>164285
location: region:162723-164285:1
so has part: feature:162723-164285:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:162723-164285:1:exon

YER006W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUG1
locus tag: YER006W
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16803892]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16803892]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:16803892]
experiment: EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:11583615]
experiment: EXISTENCE:genetic interaction:GO:0030687 preribosome, large subunit precursor [PMID:16803892]
experiment: EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11583615]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]
note: GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus
codon start: 1
product: RNA-binding GTPase NUG1
translation: MRVRKRQSRRTSTKLKEGIKKKASAHRKKEKKMAKKDVTWRSRSKKDPGIPSNFPYKAKILEEIEAKKMKDLEERELAKQQRLEARKAAKEQGVDAMDEDMIEDDENGLAALVESAQQAAAEYEGTPSNDADVRDDELDVIDYNIDFYGEDVEGESELEKSRKAYDKIFKSVIDASDVILYVLDARDPESTRSRKVEEAVLQSQGKRLILILNKVDLIPPHVLEQWLNYLKSSFPTIPLRASSGAVNGTSFNRKLSQTTTASALLESLKTYSNNSNLKRSIVVGVIGYPNVGKSSVINALLARRGGQSKACPVGNEAGVTTSLREIKIDNKLKILDSPGICFPSENKKRSKVEHEAELALLNALPAKHIVDPYPAVLMLVKRLAKSDEMTESFKKLYEIPPIPANDADTFTKHFLIHVARKRGRLGKGGIPNLASAGLSVLNDWRDGKILGWVLPNTSAAASQQDKQNLSTINTGTKQAPIAANESTIVSEWSKEFDLDGLFSSLDKAIDASKDQDTMME
SIO_010081: YER006W
subclass of: SO_0000673
so part of: YER006W
location: 162723..164285
location: region:162723-164285:1
so has part: feature:162723-164285:1:exon

NP_010921.1
type: Protein
SIO_000068: ncbiprotein

S000000808
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:162723-164285:1:exon

YER007W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAC2
locus tag: YER007W
so part of: sequence
location: <164527..>166083
location: region:164527-166083:1
so has part: feature:164527-166083:1:exon
subclass of: SO_0000010

856724
type: Gene
SIO_000068: ncbigene

position:164527:1
position: 164527
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:166083:1
position: 166083
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:164527-166083:1:exon

YER007W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAC2
locus tag: YER007W
product: Pac2p
transcript id: NM_001178898.1
SIO_010081: YER007W
subclass of: SO_0000673
so part of: YER007W
location: <164527..>166083
location: region:164527-166083:1
so has part: feature:164527-166083:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:164527-166083:1:exon

YER007W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAC2
locus tag: YER007W
experiment: EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:9215891]
experiment: EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]
experiment: EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]
experiment: EXISTENCE:physical interaction:GO:0043014 alpha-tubulin binding [PMID:9885248]
note: Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
codon start: 1
product: Pac2p
translation: MTYEIGDRLKIGGYFCTIKFIGVIKPWPSVKAYGVEWDDHSRGKHSGTIDDIHYFDVQIPNSGSFLKESKIKSPGVRRITFYEALSEKYGGSSNNINDLSIGNKRVEGLGFDELNARNKNYKKLRKIALRDSDVAILFQNQDELNRVIQNCVNVKDLDLSLNLFTNINSLCEFIEPLKNLESLNISQNKLLSGWDNLKEYDLSHIKTLRLSSCGLSYKHIGKLLKSFRTLKMLDLSYNNLTSAGIQNFENEIPCTLEELNISGNNLISFPLFPKNLTLKGLNVSNNQISRAPSIAIYSVESLDITDNKFKERSLIDDLNKTFPSLKNIHLSGNEFNYNGNYINVEEQATFYEVLARFDRVMVLNGSICDVKTRREAEMFFVSKVMNNELSYDTNLPRWSSLIKSYEIDMSKLSFNNERETRQSLVLKIKIRAGKKPSSDLDYWVLPSFTVRYVKSVICRKLNFDILNVKLFHENSEGMINEIKYNFRPISDFNVVNGDIIHVSSPVNNKSIQKVNSPS
SIO_010081: YER007W
subclass of: SO_0000673
so part of: YER007W
location: 164527..166083
location: region:164527-166083:1
so has part: feature:164527-166083:1:exon

NP_010922.1
type: Protein
SIO_000068: ncbiprotein

S000000809
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:164527-166083:1:exon

YER007C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TMA20
locus tag: YER007C-A
so part of: sequence
location: complement(<166237..>166885)
location: region:166237-166885:-1
so has part: feature:166237-166885:-1:exon
subclass of: SO_0000010

856725
type: Gene
SIO_000068: ncbigene

position:166237:-1
position: 166237
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:166885:-1
position: 166885
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:166237-166885:-1:exon

YER007C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TMA20
locus tag: YER007C-A
product: translation machinery-associated protein 20
transcript id: NM_001180857.3
SIO_010081: YER007C-A
subclass of: SO_0000673
so part of: YER007C-A
location: complement(join(<166237..166771,166875..>166885))
location: region:166237-166885:-1
so has part: feature:166875-166885:-1:exon
so has part: feature:166237-166771:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:166875-166885:-1:exon

position:166875:-1
position: 166875
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:166237-166771:-1:exon

position:166771:-1
position: 166771
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER007C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TMA20
locus tag: YER007C-A
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23613772]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16702403]
note: hypothetical protein that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
codon start: 1
product: translation machinery-associated protein 20
translation: MFKKFTREDVHSRSKVKSSIQRTLKAKLVKQYPKIEDVIDELIPKKSQIELIKCEDKIQLYSVDGEVLFFQKFDELIPSLKLVHKFPEAYPTVQVDRGAIKFVLSGANIMCPGLTSAGADLPPAPGYEKGTIVVINAENKENALAIGELMMGTEEIKSVNKGHSIELIHHLGDPLWNFSVE
SIO_010081: YER007C-A
subclass of: SO_0000673
so part of: YER007C-A
location: complement(join(166237..166771,166875..166885))
location: region:166237-166885:-1
so has part: feature:166875-166885:-1:exon
so has part: feature:166237-166771:-1:exon

NP_010923.3
type: Protein
SIO_000068: ncbiprotein

S000002957
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:166875-166885:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:166237-166771:-1:exon

YNCE0011C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR14
locus tag: YNCE0011C
so part of: sequence
location: complement(167427..167586)
location: region:167427-167586:-1
so has part: feature:167427-167586:-1:exon
subclass of: SO_0000623

9164888
type: Gene
SIO_000068: ncbigene

position:167427:-1
position: 167427
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:167586:-1
position: 167586
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167427-167586:-1:exon

YNCE0011C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snRNA
gene: SNR14
locus tag: YNCE0011C
product: SNR14
experiment: EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:2962902]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]
experiment: EXISTENCE:physical interaction:GO:0017069 snRNA binding [PMID:2440583]
note: U4 spliceosomal RNA (U4 snRNA); interacts with U6
transcript id: NR_132167.1
SIO_010081: YNCE0011C
subclass of: SO_0000673
so part of: YNCE0011C
location: complement(167427..167586)
location: region:167427-167586:-1
so has part: feature:167427-167586:-1:exon

S000006499
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167427-167586:-1:exon

YER008C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSL1
gene: SEC3
locus tag: YER008C
gene synonym: PSL1
so part of: sequence
location: complement(<167808..>171818)
location: region:167808-171818:-1
so has part: feature:167808-171818:-1:exon
subclass of: SO_0000010

856726
type: Gene
SIO_000068: ncbigene

position:167808:-1
position: 167808
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:171818:-1
position: 171818
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:167808-171818:-1:exon

YER008C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSL1
gene: SEC3
locus tag: YER008C
gene synonym: PSL1
product: GTP-Rho binding exocyst subunit SEC3
transcript id: NM_001178899.1
SIO_010081: YER008C
subclass of: SO_0000673
so part of: YER008C
location: complement(<167808..>171818)
location: region:167808-171818:-1
so has part: feature:167808-171818:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:167808-171818:-1:exon

YER008C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSL1
gene: SEC3
locus tag: YER008C
gene synonym: PSL1
experiment: EXISTENCE:curator inference:GO:0090522 vesicle tethering involved in exocytosis [PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11595741|PMID:9491896]
experiment: EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]
experiment: EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:18195105]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11595741|PMID:17717527|PMID:9491896|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11595741|PMID:9491896|PMID:22842922|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006887 exocytosis [PMID:15772160]
experiment: EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:11283608]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9491896|PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108|PMID:17717527]
experiment: EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
experiment: EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:15583030]
experiment: EXISTENCE:genetic interaction:GO:0051601 exocyst localization [PMID:17717527|PMID:18946089]
experiment: EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:15583030]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]
experiment: EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]
experiment: EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:12960429|PMID:15583030]
experiment: EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11595741]
note: Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
codon start: 1
product: GTP-Rho binding exocyst subunit SEC3
translation: MRSSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSRNVSQGAVPSSAPPVSGGNYSHKRNVSRASNSSQTSNFLAEQYERDRKAIINCCFSRPDHKTGEPPNNYITHVRIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKLIQIHKARENSDGSFQIGRTWQLTELVRVEKDLEISEGFILTMSKKYYWETNSAKERTVFIKSLITLYIQTFEGHVPELVNWDLSLFYLDERSYQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAPTERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEAELRRLEEQKRLQLQKENEMKRLEEERRIKQEERKRQMELEHQRQLEEEERKRQMELEAKKQMELKRQRQFEEEQRLKKERELLEIQRKQREQETAERLKKEEQEALAKKEEEEKSKRNKVDNESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPERSTARAHDQLKKPLNIAKVESLGGSDLNDSISLSDEIAGLNTSNLSGEDQDEKNDLSFEKGDEVRYSNNFEGEAPHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVNDECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSYQAIVENWNVSIQPVYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIETQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQVWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIKDTDEGYESIELMNSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVNSNWLTEMLSMLNFNKDGIFDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVKRLHTHMVNDFGYHQENAINNVLCDKLWSCIQGQTVSLYLKLYTVIDKHYRGTNIRFTKNDIISAFEEYKNA
SIO_010081: YER008C
subclass of: SO_0000673
so part of: YER008C
location: complement(167808..171818)
location: region:167808-171818:-1
so has part: feature:167808-171818:-1:exon

NP_010924.1
type: Protein
SIO_000068: ncbiprotein

S000000810
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:167808-171818:-1:exon

YER009W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NTF2
locus tag: YER009W
so part of: sequence
location: <172115..>172492
location: region:172115-172492:1
so has part: feature:172115-172492:1:exon
subclass of: SO_0000010

856727
type: Gene
SIO_000068: ncbigene

position:172115:1
position: 172115
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:172492:1
position: 172492
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172115-172492:1:exon

YER009W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NTF2
locus tag: YER009W
product: Ran GTPase-binding protein NTF2
transcript id: NM_001178900.1
SIO_010081: YER009W
subclass of: SO_0000673
so part of: YER009W
location: <172115..>172492
location: region:172115-172492:1
so has part: feature:172115-172492:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172115-172492:1:exon

YER009W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NTF2
locus tag: YER009W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:8702493]
experiment: EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10889207]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:8702493|PMID:11024003]
experiment: EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:8702493]
note: Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
codon start: 1
product: Ran GTPase-binding protein NTF2
translation: MSLDFNTLAQNFTQFYYNQFDTDRSQLGNLYRNESMLTFETSQLQGAKDIVEKLVSLPFQKVQHRITTLDAQPASPNGDVLVMITGDLLIDEEQNPQRFSQVFHLIPDGNSYYVFNDIFRLNYSA
SIO_010081: YER009W
subclass of: SO_0000673
so part of: YER009W
location: 172115..172492
location: region:172115-172492:1
so has part: feature:172115-172492:1:exon

NP_010925.1
type: Protein
SIO_000068: ncbiprotein

S000000811
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172115-172492:1:exon

YER010C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER010C
so part of: sequence
location: complement(<172634..>173338)
location: region:172634-173338:-1
so has part: feature:172634-173338:-1:exon
subclass of: SO_0000010

856728
type: Gene
SIO_000068: ncbigene

position:172634:-1
position: 172634
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:173338:-1
position: 173338
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:172634-173338:-1:exon

YER010C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER010C
product: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
transcript id: NM_001178901.3
SIO_010081: YER010C
subclass of: SO_0000673
so part of: YER010C
location: complement(<172634..>173338)
location: region:172634-173338:-1
so has part: feature:172634-173338:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:172634-173338:-1:exon

YER010C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER010C
EC number: 4.1.1.112
EC number: 4.1.3.17
experiment: EXISTENCE:direct assay:GO:0008948 oxaloacetate decarboxylase activity [PMID:24359411]
experiment: EXISTENCE:direct assay:GO:0019619 3,4-dihydroxybenzoate catabolic process [PMID:24359411]
experiment: EXISTENCE:direct assay:GO:0047443 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity [PMID:24359411]
note: Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate
codon start: 1
product: bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase
translation: MSDLQKLQRFSTCDISDGLLNVYNIPTGGYFPNLTAISPPQNSSIVGTAYTVLFAPIDDPRPAVNYIDSVPPNSILVLALEPHLQSQFHPFIKITQAMYGGLMSTRAQYLKSNGTVVFGRIRDVDEHRTLNHPVFAYGVGSCAPKAVVKAVGTNVQLKILTSDGVTQTICPGDYIAGDNNGIVRIPVQETDISKLVTYIEKSIEVDLLVSEDIKNGIPAKQAQNDRRSVLKKYI
SIO_010081: YER010C
subclass of: SO_0000673
so part of: YER010C
location: complement(172634..173338)
location: region:172634-173338:-1
so has part: feature:172634-173338:-1:exon

NP_010926.3
type: Protein
SIO_000068: ncbiprotein

S000000812
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:172634-173338:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS511; Autonomously Replicating Sequence
so part of: sequence
location: 173700..173864
location: region:173700-173864:1
so has part: feature:173700-173864:1:region

S000077383
type: SGD
SIO_000068: sgd

position:173700:1
position: 173700
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:173864:1
position: 173864
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:173700-173864:1:region

YER011W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SRP1
gene: TIR1
locus tag: YER011W
gene synonym: SRP1
so part of: sequence
location: <175248..>176012
location: region:175248-176012:1
so has part: feature:175248-176012:1:exon
subclass of: SO_0000010

856729
type: Gene
SIO_000068: ncbigene

position:175248:1
position: 175248
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:176012:1
position: 176012
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:175248-176012:1:exon

YER011W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SRP1
gene: TIR1
locus tag: YER011W
gene synonym: SRP1
product: GPI-anchored mannoprotein
transcript id: NM_001178902.1
SIO_010081: YER011W
subclass of: SO_0000673
so part of: YER011W
location: <175248..>176012
location: region:175248-176012:1
so has part: feature:175248-176012:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:175248-176012:1:exon

YER011W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SRP1
gene: TIR1
locus tag: YER011W
gene synonym: SRP1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:9363789]
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:8733242]
experiment: EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:9363789]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
note: Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
codon start: 1
product: GPI-anchored mannoprotein
translation: MAYTKIALFAAIAALASAQTQDQINELNVILNDVKSHLQEYISLASDSSSGFSLSSMPAGVLDIGMALASATDDSYTTLYSEVDFAGVSKMLTMVPWYSSRLEPALKSLNGDASSSAAPSSSAAPTSSAAPSSSAAPTSSAASSSSEAKSSSAAPSSSEAKSSSAAPSSSEAKSSSAAPSSSEAKSSSAAPSSTEAKITSAAPSSTGAKTSAISQITDGQIQATKAVSEQTENGAAKAFVGMGAGVVAAAAMLL
SIO_010081: YER011W
subclass of: SO_0000673
so part of: YER011W
location: 175248..176012
location: region:175248-176012:1
so has part: feature:175248-176012:1:exon

NP_010927.1
type: Protein
SIO_000068: ncbiprotein

S000000813
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:175248-176012:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 176705..176856
location: region:176705-176856:1
so has part: feature:176705-176856:1:region

S000006912
type: SGD
SIO_000068: sgd

position:176705:1
position: 176705
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:176856:1
position: 176856
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:176705-176856:1:region

YNCE0012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0012W
so part of: sequence
location: 177099..177170
location: region:177099-177170:1
so has part: feature:177099-177170:1:exon
subclass of: SO_0000663

856730
type: Gene
SIO_000068: ncbigene

position:177099:1
position: 177099
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:177170:1
position: 177170
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:177099-177170:1:exon

YNCE0012W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0012W
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; target of K. lactis zymocin
SIO_010081: YNCE0012W
subclass of: SO_0000673
so part of: YNCE0012W
location: 177099..177170
location: region:177099-177170:1
so has part: feature:177099-177170:1:exon

S000006550
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:177099-177170:1:exon

YER012W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRE1
locus tag: YER012W
so part of: sequence
location: <177835..>178431
location: region:177835-178431:1
so has part: feature:177835-178431:1:exon
subclass of: SO_0000010

856731
type: Gene
SIO_000068: ncbigene

position:177835:1
position: 177835
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:178431:1
position: 178431
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:177835-178431:1:exon

YER012W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRE1
locus tag: YER012W
product: proteasome core particle subunit beta 4
transcript id: NM_001178903.1
SIO_010081: YER012W
subclass of: SO_0000673
so part of: YER012W
location: <177835..>178431
location: region:177835-178431:1
so has part: feature:177835-178431:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:177835-178431:1:exon

YER012W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRE1
locus tag: YER012W
experiment: EXISTENCE:curator inference:GO:0034515 proteasome storage granule [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10419517]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15973433]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
experiment: EXISTENCE:mutant phenotype:GO:0061133 endopeptidase activator activity [PMID:8808631]
note: Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
codon start: 1
product: proteasome core particle subunit beta 4
translation: MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ
SIO_010081: YER012W
subclass of: SO_0000673
so part of: YER012W
location: 177835..178431
location: region:177835-178431:1
so has part: feature:177835-178431:1:exon

NP_010928.1
type: Protein
SIO_000068: ncbiprotein

S000000814
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:177835-178431:1:exon

YER013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRP22
locus tag: YER013W
so part of: sequence
location: <178841..>182278
location: region:178841-182278:1
so has part: feature:178841-182278:1:exon
subclass of: SO_0000010

856732
type: Gene
SIO_000068: ncbigene

position:178841:1
position: 178841
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:182278:1
position: 182278
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:178841-182278:1:exon

YER013W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRP22
locus tag: YER013W
product: DEAH-box ATP-dependent RNA helicase PRP22
transcript id: NM_001178904.3
SIO_010081: YER013W
subclass of: SO_0000673
so part of: YER013W
location: <178841..>182278
location: region:178841-182278:1
so has part: feature:178841-182278:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:178841-182278:1:exon

YER013W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRP22
locus tag: YER013W
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:9582286]
experiment: EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:22408182]
experiment: EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:9524130]
experiment: EXISTENCE:mutant phenotype:GO:0000390 spliceosomal complex disassembly [PMID:9524130]
experiment: EXISTENCE:mutant phenotype:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:9524130]
experiment: EXISTENCE:mutant phenotype:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]
note: DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction
codon start: 1
product: DEAH-box ATP-dependent RNA helicase PRP22
translation: MSDISKLIGAIVGSDDPVIIEFVLNIINKSGNLQEFIRNIQKLDAGISYEDSIKMYNAFLGKQEEEKVRNKVKSSPLSQKINQVLKDDVNLDDPVVTEFVLSILNKSKSITEFQEQLNLMQSGLDNETIFKIYQIASPPVMKEEVSVLPSTKIPAKIEAKIEEEVQKIESLDPSPVLHKVYEGKVRNITTFGCFVQIFGTRMKNCDGLVHISEMSDQRTLDPHDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGEIRKRNTESVEDRGRSNDAHTSRNMKNKIKRRALTSPERWEIRQLIASGAASIDDYPELKDEIPINTSYLTAKRDDGSIVNGNTEKVDSKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEMPKITKVPRGFMNRSAINGSNAIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGPGDILVFLTGQEEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQVGYKTINGGTEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKAGDAESQSRKKAKIIPLHNKFAKDQNSWRLSSIRQSRERALGIKR
SIO_010081: YER013W
subclass of: SO_0000673
so part of: YER013W
location: 178841..182278
location: region:178841-182278:1
so has part: feature:178841-182278:1:exon

NP_010929.3
type: Protein
SIO_000068: ncbiprotein

S000000815
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:178841-182278:1:exon

YER014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HEM14
locus tag: YER014W
so part of: sequence
location: <182600..>184219
location: region:182600-184219:1
so has part: feature:182600-184219:1:exon
subclass of: SO_0000010

856733
type: Gene
SIO_000068: ncbigene

position:182600:1
position: 182600
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184219:1
position: 184219
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:182600-184219:1:exon

YER014W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HEM14
locus tag: YER014W
product: oxygen-dependent protoporphyrinogen oxidase
transcript id: NM_001178905.1
SIO_010081: YER014W
subclass of: SO_0000673
so part of: YER014W
location: <182600..>184219
location: region:182600-184219:1
so has part: feature:182600-184219:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:182600-184219:1:exon

YER014W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HEM14
locus tag: YER014W
EC number: 1.3.3.4
experiment: EXISTENCE:direct assay:GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity [PMID:7798202]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7798202]
experiment: EXISTENCE:mutant phenotype:GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity [PMID:7052077]
experiment: EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]
note: Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides
codon start: 1
product: oxygen-dependent protoporphyrinogen oxidase
translation: MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK
SIO_010081: YER014W
subclass of: SO_0000673
so part of: YER014W
location: 182600..184219
location: region:182600-184219:1
so has part: feature:182600-184219:1:exon

NP_010930.1
type: Protein
SIO_000068: ncbiprotein

S000000816
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:182600-184219:1:exon

YER014C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: BUD25
locus tag: YER014C-A
so part of: sequence
location: complement(<183731..>184700)
location: region:183731-184700:-1
so has part: feature:183731-184700:-1:exon
subclass of: SO_0000010

856735
type: Gene
SIO_000068: ncbigene

position:183731:-1
position: 183731
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:184700:-1
position: 184700
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:183731-184700:-1:exon

YER014C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: BUD25
locus tag: YER014C-A
product: Bud25p
transcript id: NM_001184456.1
SIO_010081: YER014C-A
subclass of: SO_0000673
so part of: YER014C-A
location: complement(join(<183731..184169,184678..>184700))
location: region:183731-184700:-1
so has part: feature:184678-184700:-1:exon
so has part: feature:183731-184169:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184678-184700:-1:exon

position:184678:-1
position: 184678
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:183731-184169:-1:exon

position:184169:-1
position: 184169
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER014C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: BUD25
locus tag: YER014C-A
experiment: EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]
note: Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
codon start: 1
product: Bud25p
translation: MFCTWDSWDTGTSRKSHSPHRNCLAVRFLQLPFSSFLPCVITYMKSWQTSIGDSEFPLTSFQILVTDAEVVVQRIFDCINGYLPGWHYRNTVFIEHTTSYHRSHFCIFVEGVWVCGEFVKKWFEIPFDNRIENYTKQFPWILIGFGNQVSKAL
SIO_010081: YER014C-A
subclass of: SO_0000673
so part of: YER014C-A
location: complement(join(183731..184169,184678..184700))
location: region:183731-184700:-1
so has part: feature:184678-184700:-1:exon
so has part: feature:183731-184169:-1:exon

NP_076437.1
type: Protein
SIO_000068: ncbiprotein

S000007590
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184678-184700:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:183731-184169:-1:exon

YER015W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FAM1
gene: FAA2
locus tag: YER015W
gene synonym: FAM1
so part of: sequence
location: <184541..>186775
location: region:184541-186775:1
so has part: feature:184541-186775:1:exon
subclass of: SO_0000010

856734
type: Gene
SIO_000068: ncbigene

position:184541:1
position: 184541
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:186775:1
position: 186775
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:184541-186775:1:exon

YER015W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FAM1
gene: FAA2
locus tag: YER015W
gene synonym: FAM1
product: medium-chain fatty acid-CoA ligase FAA2
transcript id: NM_001178906.3
SIO_010081: YER015W
subclass of: SO_0000673
so part of: YER015W
location: <184541..>186775
location: region:184541-186775:1
so has part: feature:184541-186775:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:184541-186775:1:exon

YER015W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FAM1
gene: FAA2
locus tag: YER015W
gene synonym: FAM1
EC number: 6.2.1.3
experiment: EXISTENCE:direct assay:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:8206942]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:8670886]
experiment: EXISTENCE:direct assay:GO:0031956 medium-chain fatty acid-CoA ligase activity [PMID:8206942]
experiment: EXISTENCE:genetic interaction:GO:0001676 long-chain fatty acid metabolic process [PMID:7962057]
experiment: EXISTENCE:genetic interaction:GO:0031957 very long-chain fatty acid-CoA ligase activity [PMID:9988704]
experiment: EXISTENCE:mutant phenotype:GO:0001676 long-chain fatty acid metabolic process [PMID:7962057]
note: Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon
codon start: 1
product: medium-chain fatty acid-CoA ligase FAA2
translation: MAAPDYALTDLIESDPRFESLKTRLAGYTKGSDEYIEELYSQLPLTSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSSLSSENLVSCVDKNLRTAYDHFMFSARRWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEANDFVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMYHVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCFNKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLYDMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRFEAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGLSNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIGISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVAFIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGIVGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCTDGLQGFEKLHNIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL
SIO_010081: YER015W
subclass of: SO_0000673
so part of: YER015W
location: 184541..186775
location: region:184541-186775:1
so has part: feature:184541-186775:1:exon

NP_010931.3
type: Protein
SIO_000068: ncbiprotein

S000000817
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:184541-186775:1:exon

YER016W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YEB1
gene: BIM1
locus tag: YER016W
gene synonym: YEB1
so part of: sequence
location: <188277..>189311
location: region:188277-189311:1
so has part: feature:188277-189311:1:exon
subclass of: SO_0000010

856736
type: Gene
SIO_000068: ncbigene

position:188277:1
position: 188277
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:189311:1
position: 189311
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:188277-189311:1:exon

YER016W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YEB1
gene: BIM1
locus tag: YER016W
gene synonym: YEB1
product: microtubule-binding protein BIM1
transcript id: NM_001178907.1
SIO_010081: YER016W
subclass of: SO_0000673
so part of: YER016W
location: <188277..>189311
location: region:188277-189311:1
so has part: feature:188277-189311:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:188277-189311:1:exon

YER016W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YEB1
gene: BIM1
locus tag: YER016W
gene synonym: YEB1
experiment: EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:10352017]
experiment: EXISTENCE:direct assay:GO:0005819 spindle [PMID:10352017]
experiment: EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:10352017]
experiment: EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:20392838]
experiment: EXISTENCE:direct assay:GO:0035371 microtubule plus-end [PMID:20392838]
experiment: EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20392838]
experiment: EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:10352017]
experiment: EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]
experiment: EXISTENCE:genetic interaction:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:11285282]
experiment: EXISTENCE:mutant phenotype:GO:0007019 microtubule depolymerization [PMID:10352017]
experiment: EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]
experiment: EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:10352017]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]
experiment: EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:10352017]
experiment: EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]
experiment: EXISTENCE:mutant phenotype:GO:1904825 protein localization to microtubule plus-end [PMID:29576319]
note: Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)
codon start: 1
product: microtubule-binding protein BIM1
translation: MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF
SIO_010081: YER016W
subclass of: SO_0000673
so part of: YER016W
location: 188277..189311
location: region:188277-189311:1
so has part: feature:188277-189311:1:exon

NP_010932.1
type: Protein
SIO_000068: ncbiprotein

S000000818
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:188277-189311:1:exon

YER017C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YTA10
gene: AFG3
locus tag: YER017C
gene synonym: YTA10
so part of: sequence
location: complement(<189503..>191788)
location: region:189503-191788:-1
so has part: feature:189503-191788:-1:exon
subclass of: SO_0000010

856737
type: Gene
SIO_000068: ncbigene

position:189503:-1
position: 189503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:191788:-1
position: 191788
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:189503-191788:-1:exon

YER017C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YTA10
gene: AFG3
locus tag: YER017C
gene synonym: YTA10
product: AAA family ATPase AFG3
transcript id: NM_001178908.1
SIO_010081: YER017C
subclass of: SO_0000673
so part of: YER017C
location: complement(<189503..>191788)
location: region:189503-191788:-1
so has part: feature:189503-191788:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:189503-191788:-1:exon

YER017C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YTA10
gene: AFG3
locus tag: YER017C
gene synonym: YTA10
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23509072]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7926051]
experiment: EXISTENCE:direct assay:GO:0005745 m-AAA complex [PMID:8681382]
experiment: EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:19748354]
experiment: EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:19019989]
experiment: EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:12417197]
experiment: EXISTENCE:mutant phenotype:GO:0008237 metallopeptidase activity [PMID:8681382]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:19748354]
experiment: EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:27398316]
experiment: EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:8681382]
note: Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant
codon start: 1
product: AAA family ATPase AFG3
translation: MMMWQRYARGAPRSLTSLSFGKASRISTVKPVLRSRMPVHQRLQTLSGLATRNTIHRSTQIRSFHISWTRLNENRPNKEGEGKNNGNKDNNSNKEDGKDKRNEFGSLSEYFRSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEKGLVSKIYVVNKFLVEAELVNTKQVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPIKYIERSSPFTFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKETDIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDEREATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLKRLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVIAGLEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLLKVSIIPRGQGALGYAQYLPPDQYLISEEQFRHRMIMALGGRVSEELHFPSVTSGAHDDFKKVTQMANAMVTSLGMSPKIGYLSFDQNDGNFKVNKPFSNKTARTIDLEVKSIVDDAHRACTELLTKNLDKVDLVAKELLRKEAITREDMIRLLGPRPFKERNEAFEKYLDPKSNTEPPEAPAATN
SIO_010081: YER017C
subclass of: SO_0000673
so part of: YER017C
location: complement(189503..191788)
location: region:189503-191788:-1
so has part: feature:189503-191788:-1:exon

NP_010933.1
type: Protein
SIO_000068: ncbiprotein

S000000819
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:189503-191788:-1:exon

YER018C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPC25
locus tag: YER018C
so part of: sequence
location: complement(<191959..>192624)
location: region:191959-192624:-1
so has part: feature:191959-192624:-1:exon
subclass of: SO_0000010

856738
type: Gene
SIO_000068: ncbigene

position:191959:-1
position: 191959
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:192624:-1
position: 192624
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:191959-192624:-1:exon

YER018C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPC25
locus tag: YER018C
product: kinetochore-associated Ndc80 complex subunit SPC25
transcript id: NM_001178909.3
SIO_010081: YER018C
subclass of: SO_0000673
so part of: YER018C
location: complement(<191959..>192624)
location: region:191959-192624:-1
so has part: feature:191959-192624:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:191959-192624:-1:exon

YER018C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPC25
locus tag: YER018C
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]
experiment: EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11179222|PMID:11266451]
experiment: EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11266451]
experiment: EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:11179222]
experiment: EXISTENCE:physical interaction:GO:0031262 Ndc80 complex [PMID:11179222]
note: Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p
codon start: 1
product: kinetochore-associated Ndc80 complex subunit SPC25
translation: MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQLHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAAQSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVFGDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL
SIO_010081: YER018C
subclass of: SO_0000673
so part of: YER018C
location: complement(191959..192624)
location: region:191959-192624:-1
so has part: feature:191959-192624:-1:exon

NP_010934.3
type: Protein
SIO_000068: ncbiprotein

S000000820
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:191959-192624:-1:exon

YER019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ISC1
locus tag: YER019W
so part of: sequence
location: <192797..>194230
location: region:192797-194230:1
so has part: feature:192797-194230:1:exon
subclass of: SO_0000010

856739
type: Gene
SIO_000068: ncbigene

position:192797:1
position: 192797
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194230:1
position: 194230
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:192797-194230:1:exon

YER019W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ISC1
locus tag: YER019W
product: inositol phosphosphingolipid phospholipase
transcript id: NM_001178910.1
SIO_010081: YER019W
subclass of: SO_0000673
so part of: YER019W
location: <192797..>194230
location: region:192797-194230:1
so has part: feature:192797-194230:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:192797-194230:1:exon

YER019W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ISC1
locus tag: YER019W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14699160]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:17880915]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14699160|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0030149 sphingolipid catabolic process [PMID:11006294]
experiment: EXISTENCE:direct assay:GO:0052712 inositol phosphosphingolipid phospholipase activity [PMID:11006294]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:12180980]
experiment: EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:17880915|PMID:23620586]
experiment: EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:32205408]
note: Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2
codon start: 1
product: inositol phosphosphingolipid phospholipase
translation: MYNRKDRDVHERKEDGQSEFEALNGTNAIMSDNSKAYSIKFLTFNTWGLKYVSKHRKERLRAIADKLAGHSMLTPISDELLPNGGDSNENEDYDVIALQEIWCVEDWKYLASACASKYPYQRLFHSGILTGPGLAILSKVPIESTFLYRFPINGRPSAVFRGDWYVGKSIAITVLNTGTRPIAIMNSHMHAPYAKQGDAAYLCHRSCQAWDFSRLIKLYRQAGYAVIVVGDLNSRPGSLPHKFLTQEAGLVDSWEQLHGKQDLAVIARLSPLQQLLKGCTTCDSLLNTWRAQRQPDEACRLDYALIDPDFLQTVDAGVRFTERIPHLDCSVSDHFAYSCTLNIVPQGTESRPSTSVKRAKTHDRELILQRYSNYETMIECIHTYLKTAQRQKFFRGLHFWASILLLIASLVVTTFTANKAGWSSIFWVLFAIAVSISGTIDGAISFLFGRSEIRALIEVEQEVLDAEHHLQTFLSEK
SIO_010081: YER019W
subclass of: SO_0000673
so part of: YER019W
location: 192797..194230
location: region:192797-194230:1
so has part: feature:192797-194230:1:exon

NP_010935.1
type: Protein
SIO_000068: ncbiprotein

S000000821
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:192797-194230:1:exon

YER019C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEB2
gene: SBH2
locus tag: YER019C-A
gene synonym: SEB2
so part of: sequence
location: complement(<194273..>194539)
location: region:194273-194539:-1
so has part: feature:194273-194539:-1:exon
subclass of: SO_0000010

856740
type: Gene
SIO_000068: ncbigene

position:194273:-1
position: 194273
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:194539:-1
position: 194539
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:194273-194539:-1:exon

YER019C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEB2
gene: SBH2
locus tag: YER019C-A
gene synonym: SEB2
product: Arf family guanine nucleotide exchange factor SBH2
transcript id: NM_001180031.1
SIO_010081: YER019C-A
subclass of: SO_0000673
so part of: YER019C-A
location: complement(<194273..>194539)
location: region:194273-194539:-1
so has part: feature:194273-194539:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:194273-194539:-1:exon

YER019C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEB2
gene: SBH2
locus tag: YER019C-A
gene synonym: SEB2
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12750387]
experiment: EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:27831485]
experiment: EXISTENCE:direct assay:GO:0071261 Ssh1 translocon complex [PMID:8612571]
experiment: EXISTENCE:genetic interaction:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:18347066]
note: Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication
codon start: 1
product: Arf family guanine nucleotide exchange factor SBH2
translation: MAASVPPGGQRILQKRRQAQSIKEKQAKQTPTSTRQAGYGGSSSSILKLYTDEANGFRVDSLVVLFLSVGFIFSVIALHLLTKFTHII
SIO_010081: YER019C-A
subclass of: SO_0000673
so part of: YER019C-A
location: complement(194273..194539)
location: region:194273-194539:-1
so has part: feature:194273-194539:-1:exon

NP_010936.1
type: Protein
SIO_000068: ncbiprotein

S000002127
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:194273-194539:-1:exon

YER020W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSP101
gene: GPA2
locus tag: YER020W
gene synonym: SSP101
so part of: sequence
location: <195168..>196517
location: region:195168-196517:1
so has part: feature:195168-196517:1:exon
subclass of: SO_0000010

856741
type: Gene
SIO_000068: ncbigene

position:195168:1
position: 195168
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:196517:1
position: 196517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:195168-196517:1:exon

YER020W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSP101
gene: GPA2
locus tag: YER020W
gene synonym: SSP101
product: guanine nucleotide-binding protein subunit alpha
transcript id: NM_001178911.3
SIO_010081: YER020W
subclass of: SO_0000673
so part of: YER020W
location: <195168..>196517
location: region:195168-196517:1
so has part: feature:195168-196517:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:195168-196517:1:exon

YER020W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSP101
gene: GPA2
locus tag: YER020W
gene synonym: SSP101
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16924114]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31690628]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030250|PMID:31690628|PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0010737 protein kinase A signaling [PMID:31690628]
experiment: EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:10361302|PMID:2830616]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]
experiment: EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:9384580]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:10454558|PMID:10655215|PMID:9384580]
experiment: EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:10454558]
experiment: EXISTENCE:mutant phenotype:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:9628870]
experiment: EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]
experiment: EXISTENCE:mutant phenotype:GO:0009757 hexose mediated signaling [PMID:10655215]
experiment: EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:2830616|PMID:9628870]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10454558]
experiment: EXISTENCE:physical interaction:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:16924114]
note: Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus
codon start: 1
product: guanine nucleotide-binding protein subunit alpha
translation: MGLCASSEKNGSTPDTQTASAGSDNVGKAKVPPKQEPQKTVRTVNTANQQEKQQQRQQQPSPHNVKDRKEQNGSINNAISPTATANTSGSQQINIDSALRDRSSNVAAQPSLSDASSGSNDKELKVLLLGAGESGKSTVLQQLKILHQNGFSEQEIKEYIPLIYQNLLEIGRNLIQARTRFNVNLEPECELTQQDLSRTMSYEMPNNYTGQFPEDIAGVISTLWALPSTQDLVNGPNASKFYLMDSTPYFMENFTRITSPNYRPTQQDILRSRQMTSGIFDTVIDMGSDIKMHIYDVGGQRSERKKWIHCFDNVTLVIFCVSLSEYDQTLMEDKNQNRFQESLVLFDNIVNSRWFARTSVVLFLNKIDLFAEKLSKVPMENYFPDYTGGSDINKAAKYILWRFVQLNRANLSIYPHVTQATDTSNIRLVFAAIKETILENTLKDSGVLQ
SIO_010081: YER020W
subclass of: SO_0000673
so part of: YER020W
location: 195168..196517
location: region:195168-196517:1
so has part: feature:195168-196517:1:exon

NP_010937.3
type: Protein
SIO_000068: ncbiprotein

S000000822
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:195168-196517:1:exon

YER021W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SUN2
gene: RPN3
locus tag: YER021W
gene synonym: SUN2
so part of: sequence
location: <196948..>198519
location: region:196948-198519:1
so has part: feature:196948-198519:1:exon
subclass of: SO_0000010

856742
type: Gene
SIO_000068: ncbigene

position:196948:1
position: 196948
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:198519:1
position: 198519
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:196948-198519:1:exon

YER021W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SUN2
gene: RPN3
locus tag: YER021W
gene synonym: SUN2
product: proteasome regulatory particle lid subunit RPN3
transcript id: NM_001178912.1
SIO_010081: YER021W
subclass of: SO_0000673
so part of: YER021W
location: <196948..>198519
location: region:196948-198519:1
so has part: feature:196948-198519:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:196948-198519:1:exon

YER021W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SUN2
gene: RPN3
locus tag: YER021W
gene synonym: SUN2
experiment: EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]
note: Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
codon start: 1
product: proteasome regulatory particle lid subunit RPN3
translation: MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDLSSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYSVNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEYLVSMRYPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDLDDLGFL
SIO_010081: YER021W
subclass of: SO_0000673
so part of: YER021W
location: 196948..198519
location: region:196948-198519:1
so has part: feature:196948-198519:1:exon

NP_010938.1
type: Protein
SIO_000068: ncbiprotein

S000000823
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:196948-198519:1:exon

YER022W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MED17
gene: SRB4
locus tag: YER022W
gene synonym: MED17
so part of: sequence
location: <198812..>200875
location: region:198812-200875:1
so has part: feature:198812-200875:1:exon
subclass of: SO_0000010

856743
type: Gene
SIO_000068: ncbigene

position:198812:1
position: 198812
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:200875:1
position: 200875
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:198812-200875:1:exon

YER022W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MED17
gene: SRB4
locus tag: YER022W
gene synonym: MED17
product: Srb4p
transcript id: NM_001178913.1
SIO_010081: YER022W
subclass of: SO_0000673
so part of: YER022W
location: <198812..>200875
location: region:198812-200875:1
so has part: feature:198812-200875:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:198812-200875:1:exon

YER022W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MED17
gene: SRB4
locus tag: YER022W
gene synonym: MED17
experiment: EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]
experiment: EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]
experiment: EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:9660972]
experiment: EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:19805365]
experiment: EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:16263706]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:33789343]
experiment: EXISTENCE:physical interaction:GO:0001139 RNA polymerase II complex recruiting activity [PMID:21415355]
note: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
codon start: 1
product: Srb4p
translation: MTTEDPDSNHLSSETGIKLALDPNLITLALSSNPNSSLHSPTSDEPVPESAGKADTSIRLEGDELENKTKKDNDKNLKFLKNKDSLVSNPHEIYGSMPLEQLIPIILRQRGPGFKFVDLNEKELQNEIKQLGSDSSDGHNSEKKDTDGADENVQIGEDFMEVDYEDKDNPVDSRNETDHKTNENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSSVKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKLQSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYGYEDSGSTYKHDRGIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIESEDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALLISYGVSIENENKVIIELPNEKFEIELLSLDDDSIVNHEQDLPKINDKRANLMLVMLRLLLVVIFKKTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKIIKDYVLDIVPGSSITETEVEREQPQENKNIDDENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLMLESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVEDFLHFIVAEYIQQKKV
SIO_010081: YER022W
subclass of: SO_0000673
so part of: YER022W
location: 198812..200875
location: region:198812-200875:1
so has part: feature:198812-200875:1:exon

NP_010939.1
type: Protein
SIO_000068: ncbiprotein

S000000824
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:198812-200875:1:exon

YER023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ORE2
gene: PRO3
locus tag: YER023W
gene synonym: ORE2
so part of: sequence
location: <201076..>201936
location: region:201076-201936:1
so has part: feature:201076-201936:1:exon
subclass of: SO_0000010

856744
type: Gene
SIO_000068: ncbigene

position:201076:1
position: 201076
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:201936:1
position: 201936
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:201076-201936:1:exon

YER023W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ORE2
gene: PRO3
locus tag: YER023W
gene synonym: ORE2
product: pyrroline-5-carboxylate reductase
transcript id: NM_001178914.3
SIO_010081: YER023W
subclass of: SO_0000673
so part of: YER023W
location: <201076..>201936
location: region:201076-201936:1
so has part: feature:201076-201936:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:201076-201936:1:exon

YER023W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ORE2
gene: PRO3
locus tag: YER023W
gene synonym: ORE2
EC number: 1.5.1.2
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7009582]
experiment: EXISTENCE:mutant phenotype:GO:0004735 pyrroline-5-carboxylate reductase activity [PMID:1508147|PMID:2824433]
experiment: EXISTENCE:mutant phenotype:GO:0006561 proline biosynthetic process [PMID:1508147|PMID:2824433]
note: Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis
codon start: 1
product: pyrroline-5-carboxylate reductase
translation: MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK
SIO_010081: YER023W
subclass of: SO_0000673
so part of: YER023W
location: 201076..201936
location: region:201076-201936:1
so has part: feature:201076-201936:1:exon

NP_010940.3
type: Protein
SIO_000068: ncbiprotein

S000000825
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:201076-201936:1:exon

YER024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YAT2
locus tag: YER024W
so part of: sequence
location: <202192..>204963
location: region:202192-204963:1
so has part: feature:202192-204963:1:exon
subclass of: SO_0000010

856745
type: Gene
SIO_000068: ncbigene

position:202192:1
position: 202192
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:204963:1
position: 204963
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:202192-204963:1:exon

YER024W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YAT2
locus tag: YER024W
product: carnitine O-acetyltransferase YAT2
transcript id: NM_001178915.1
SIO_010081: YER024W
subclass of: SO_0000673
so part of: YER024W
location: <202192..>204963
location: region:202192-204963:1
so has part: feature:202192-204963:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:202192-204963:1:exon

YER024W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YAT2
locus tag: YER024W
EC number: 2.3.1.7
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18427809]
experiment: EXISTENCE:mutant phenotype:GO:0004092 carnitine O-acetyltransferase activity [PMID:11329169]
experiment: EXISTENCE:mutant phenotype:GO:0006066 alcohol metabolic process [PMID:11329169]
experiment: EXISTENCE:mutant phenotype:GO:0009437 carnitine metabolic process [PMID:11329169]
note: Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
codon start: 1
product: carnitine O-acetyltransferase YAT2
translation: MSSGSTIVSSDKSGRTFKHEEELPKLPLPKLCDTLQRLKESLEPLYYADGYYQHPLDPEQIEKLSSIIRDFEENPVSEKLQSKLQSYHDTRDCYLDELHLDINNQTSTREIQDDVLPRNPFLVLADDALPNITQADRSAVLVHSAARFISALKQDLLPPDINATNGKPLSMAPFLNLFGTTRSPVFQRGEVENFDLNKPYTASDLEDPDYSSDEDDNDEPTQKDFDDRKRKHEEDIFTGNGITIKRHPDSKHILIISRGQYYTLEVLDSTNKIIYTAAELTTIFNHIIKDSSGIEKSTALGSLTSHSFRNWKYARKRLQKRYPNELHRIDSALFVLVLDESQEETTNDGDDTADISQMFNRTITERDKKCTSANCKRVFYGTSIINSKGHQVGSCVSRWYDKLQLVVTADAKATVIWDSFTCDGSVVLRFTSEIYTESVLRLARDVNAGDPQFSLWPNVTQMDPETKKLMTATISADGGGPSEIDPKLVVNKIDWSFSNILNTHVHLSETKLADLISKYDIVRASIPLGRRSAQRLGVKPDSMVQVALQIAHYALYGRMVFGLEPVSTRGFKNSRSSFINIQSQALLELCQLFISSSIDGTDKLDKFIQTCETHNNMVKHAKSGVGYEKHFNALKYLFKFHDHFGIHLSGDESSAAKDLFENPLVLPFSQPELIVANCGNAATTTFGITPAVPHGFGIGYIIKDDQVDLTVTSQFRQGDRLMFMLSWVLGEIRSYWRMSRGTSHNKTGVKISPVVDKLYEMDNAVNNPPKRNGHTVNGSRKTSSSSQVNLNRYGGFFDLEGHIDSRNISKTPSMKNLQKTFNGLTMSADNDHSSSAVSVPTEKEKLNTGHEILQIQPREVASNGLEADDETDIEIVAGNADGTSSSASSATSLNSKKRNVINSRFDIDFDRSRVGRKVATLDQ
SIO_010081: YER024W
subclass of: SO_0000673
so part of: YER024W
location: 202192..204963
location: region:202192-204963:1
so has part: feature:202192-204963:1:exon

NP_010941.1
type: Protein
SIO_000068: ncbiprotein

S000000826
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:202192-204963:1:exon

YER025W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SUI4
gene: GCD11
locus tag: YER025W
gene synonym: SUI4
so part of: sequence
location: <205251..>206834
location: region:205251-206834:1
so has part: feature:205251-206834:1:exon
subclass of: SO_0000010

856746
type: Gene
SIO_000068: ncbigene

position:205251:1
position: 205251
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:206834:1
position: 206834
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:205251-206834:1:exon

YER025W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SUI4
gene: GCD11
locus tag: YER025W
gene synonym: SUI4
product: translation initiation factor eIF2 subunit gamma
transcript id: NM_001178916.1
SIO_010081: YER025W
subclass of: SO_0000673
so part of: YER025W
location: <205251..>206834
location: region:205251-206834:1
so has part: feature:205251-206834:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:205251-206834:1:exon

YER025W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SUI4
gene: GCD11
locus tag: YER025W
gene synonym: SUI4
EC number: 3.6.5.3
experiment: EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]
experiment: EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14698289|PMID:16246727]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]
experiment: EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:22683627]
experiment: EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]
experiment: EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]
experiment: EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]
experiment: EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:8947054]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:23063529]
experiment: EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:8947054]
experiment: EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:8417348]
experiment: EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:23063529]
experiment: EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:9308967]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22683627]
note: Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome
codon start: 1
product: translation initiation factor eIF2 subunit gamma
translation: MSDLQDQEPSIIINGNLEPVGEPDIVEETEVVAQETQETQDADKPKKKVAFTGLEEDGETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATIKKGTTLEPIA
SIO_010081: YER025W
subclass of: SO_0000673
so part of: YER025W
location: 205251..206834
location: region:205251-206834:1
so has part: feature:205251-206834:1:exon

NP_010942.1
type: Protein
SIO_000068: ncbiprotein

S000000827
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:205251-206834:1:exon

YNCE0013W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0013W
so part of: sequence
location: 207357..207428
location: region:207357-207428:1
so has part: feature:207357-207428:1:exon
subclass of: SO_0000663

856747
type: Gene
SIO_000068: ncbigene

position:207357:1
position: 207357
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:207428:1
position: 207428
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:207357-207428:1:exon

YNCE0013W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0013W
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0013W
subclass of: SO_0000673
so part of: YNCE0013W
location: 207357..207428
location: region:207357-207428:1
so has part: feature:207357-207428:1:exon

S000006593
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:207357-207428:1:exon

YER026C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PSS1
gene: CHO1
locus tag: YER026C
gene synonym: PSS1
so part of: sequence
location: complement(<207644..>208474)
location: region:207644-208474:-1
so has part: feature:207644-208474:-1:exon
subclass of: SO_0000010

856748
type: Gene
SIO_000068: ncbigene

position:207644:-1
position: 207644
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:208474:-1
position: 208474
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:207644-208474:-1:exon

YER026C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PSS1
gene: CHO1
locus tag: YER026C
gene synonym: PSS1
product: CDP-diacylglycerol-serine O-phosphatidyltransferase
transcript id: NM_001178917.3
SIO_010081: YER026C
subclass of: SO_0000673
so part of: YER026C
location: complement(<207644..>208474)
location: region:207644-208474:-1
so has part: feature:207644-208474:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:207644-208474:-1:exon

YER026C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PSS1
gene: CHO1
locus tag: YER026C
gene synonym: PSS1
EC number: 2.7.8.8
experiment: EXISTENCE:direct assay:GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity [PMID:6088519]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]
experiment: EXISTENCE:direct assay:GO:0006659 phosphatidylserine biosynthetic process [PMID:6088519]
experiment: EXISTENCE:direct assay:GO:0016020 membrane [PMID:6274497]
experiment: EXISTENCE:mutant phenotype:GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity [PMID:6988386]
experiment: EXISTENCE:mutant phenotype:GO:0006659 phosphatidylserine biosynthetic process [PMID:6988386|PMID:3031455]
note: Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline
codon start: 1
product: CDP-diacylglycerol-serine O-phosphatidyltransferase
translation: MVESDEDFAPQEFPHTDTDVIVNEHRDENDGYASDEVGGTLSRRASSIFSINTTPLAPPNATDIQKFTSDEHHFSMMRNLHMADYITMLNGFSGFYSIVSCLRFTLTGKPHYVQRAHFFILLGMCFDFLDGRVARLRNRSSLMGQELDSLADLVSFGVAPAAIAFAIGFQTTFDVMILSFFVLCGLARLARFNVTVAQLPKDSSTGKSKYFEGLPMPTTLALVLGMAYCVRKGLIFDNIPFGIFREDQILEFHPIILVFFIHGCGMISKSLKIPKP
SIO_010081: YER026C
subclass of: SO_0000673
so part of: YER026C
location: complement(207644..208474)
location: region:207644-208474:-1
so has part: feature:207644-208474:-1:exon

NP_010943.3
type: Protein
SIO_000068: ncbiprotein

S000000828
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:207644-208474:-1:exon

YER027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SPM1
gene: GAL83
locus tag: YER027C
gene synonym: SPM1
so part of: sequence
location: complement(<208979..>210232)
location: region:208979-210232:-1
so has part: feature:208979-210232:-1:exon
subclass of: SO_0000010

856749
type: Gene
SIO_000068: ncbigene

position:208979:-1
position: 208979
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:210232:-1
position: 210232
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:208979-210232:-1:exon

YER027C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SPM1
gene: GAL83
locus tag: YER027C
gene synonym: SPM1
product: Gal83p
transcript id: NM_001178918.1
SIO_010081: YER027C
subclass of: SO_0000673
so part of: YER027C
location: complement(<208979..>210232)
location: region:208979-210232:-1
so has part: feature:208979-210232:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:208979-210232:-1:exon

YER027C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SPM1
gene: GAL83
locus tag: YER027C
gene synonym: SPM1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11331606|PMID:17237508]
experiment: EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508]
experiment: EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914]
experiment: EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:10990457]
experiment: EXISTENCE:genetic interaction:GO:0007165 signal transduction [PMID:10990457]
experiment: EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:9121458]
experiment: EXISTENCE:genetic interaction:GO:0140767 enzyme-substrate adaptor activity [PMID:27592031]
experiment: EXISTENCE:genetic interaction:GO:2000222 positive regulation of pseudohyphal growth [PMID:16980405]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12556493]
experiment: EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:7813428]
experiment: EXISTENCE:mutant phenotype:GO:0007155 cell adhesion [PMID:12556493]
experiment: EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:7813428|PMID:9121458]
note: One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain
codon start: 1
product: Gal83p
translation: MAGDNPENKDASMLDVSDAASNTTINGKHSADSTNEASLAYTFSQMNVDNPNELEPQHPLRHKSSLIFNDDDDDEIPPYSNHAENGSGETFDSDDDIDASSSSSIDSNEGDIHDADMTGNTLQKMDYQPSQQPDSLQNQGFQQQQEQQQGTVEGKKGRAMMFPVDITWQQGGNKVYVTGSFTGWRKMIGLVPVPGQPGLMHVKLQLPPGTHRFRFIVDNELRFSDYLPTATDQMGNFVNYMEVSAPPDWGNEPQQHLAEKKANHVDDSKLSKRPMSARSRIALEIEKEPDDMGDGYTRFHDETPAKPNLEYTQDIPAVFTDPNVMEQYYLTLDQQQNNHQNMAWLTPPQLPPHLENVILNSYSNAQTDNTSGALPIPNHVILNHLATSSIKHNTLCVASIVRYKQKYVTQILYTPLQ
SIO_010081: YER027C
subclass of: SO_0000673
so part of: YER027C
location: complement(208979..210232)
location: region:208979-210232:-1
so has part: feature:208979-210232:-1:exon

NP_010944.1
type: Protein
SIO_000068: ncbiprotein

S000000829
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:208979-210232:-1:exon

YER028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MIG3
locus tag: YER028C
so part of: sequence
location: complement(<210692..>211876)
location: region:210692-211876:-1
so has part: feature:210692-211876:-1:exon
subclass of: SO_0000010

856750
type: Gene
SIO_000068: ncbigene

position:210692:-1
position: 210692
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:211876:-1
position: 211876
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:210692-211876:-1:exon

YER028C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MIG3
locus tag: YER028C
product: Mig3p
transcript id: NM_001178919.1
SIO_010081: YER028C
subclass of: SO_0000673
so part of: YER028C
location: complement(<210692..>211876)
location: region:210692-211876:-1
so has part: feature:210692-211876:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:210692-211876:-1:exon

YER028C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MIG3
locus tag: YER028C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:19680226]
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12239282|PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19680226]
experiment: EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:14993292]
experiment: EXISTENCE:genetic interaction:GO:0034644 cellular response to UV [PMID:19680226]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19680226]
experiment: EXISTENCE:mutant phenotype:GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose [PMID:23275883]
experiment: EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:23275883]
note: Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
codon start: 1
product: Mig3p
translation: MNYLRDRFPPDNDQRPFRCEICSRGFHRLEHKKRHGRTHTGEKPHKCTVQGCPKSFSRSDELKRHLRTHTKGVQRRRIKSKGSRKTVVNTATAAPTTFNENTGVSLTGIGQSKVPPILISVAQNCDDVNIRNTGNNNGIVETQAPAILVPVINIPNDPHPIPSSLSTTSITSIASVYPSTSPFQYLKSGFPEDPASTPYVHSSGSSLALGELSSNSSIFSKSRRNLAAMSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPPTDLSPLRRIMPSVNTGDMEISRTVSVSSSSSSLTSVTYDDTAAKDMGMGIFFDRPPVTQKACRSNHKYKVNAVSRGRQHERAQFHISGDDEDSNVHRQESRASNTSPNVSLPPIKSILRQIDNFNSAPSYFSK
SIO_010081: YER028C
subclass of: SO_0000673
so part of: YER028C
location: complement(210692..211876)
location: region:210692-211876:-1
so has part: feature:210692-211876:-1:exon

NP_010945.1
type: Protein
SIO_000068: ncbiprotein

S000000830
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:210692-211876:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS512; Autonomously Replicating Sequence
so part of: sequence
location: 212383..212631
location: region:212383-212631:1
so has part: feature:212383-212631:1:region

S000077384
type: SGD
SIO_000068: sgd

position:212383:1
position: 212383
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:212631:1
position: 212631
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212383-212631:1:region

YER029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SMB1
locus tag: YER029C
so part of: sequence
location: complement(<212587..>213177)
location: region:212587-213177:-1
so has part: feature:212587-213177:-1:exon
subclass of: SO_0000010

856751
type: Gene
SIO_000068: ncbigene

position:212587:-1
position: 212587
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:213177:-1
position: 213177
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:212587-213177:-1:exon

YER029C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SMB1
locus tag: YER029C
product: mRNA splicing protein SMB1
transcript id: NM_001178920.3
SIO_010081: YER029C
subclass of: SO_0000673
so part of: YER029C
location: complement(<212587..>213177)
location: region:212587-213177:-1
so has part: feature:212587-213177:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:212587-213177:-1:exon

YER029C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SMB1
locus tag: YER029C
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]
experiment: EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]
note: Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'
codon start: 1
product: mRNA splicing protein SMB1
translation: MSKIQVAHSSRLANLIDYKLRVLTQDGRVYIGQLMAFDKHMNLVLNECIEERVPKTQLDKLRPRKDSKDGTTLNIKVEKRVLGLTILRGEQILSTVVEDKPLLSKKERLVRDKKEKKQAQKQTKLRKEKEKKPGKIAKPNTANAKHTSSNSREIAQPSSSRYNGGNDNIGANRSRFNNEAPPQTRKFQPPPGFKRK
SIO_010081: YER029C
subclass of: SO_0000673
so part of: YER029C
location: complement(212587..213177)
location: region:212587-213177:-1
so has part: feature:212587-213177:-1:exon

NP_010946.3
type: Protein
SIO_000068: ncbiprotein

S000000831
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:212587-213177:-1:exon

YER030W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CHZ1
locus tag: YER030W
so part of: sequence
location: <213437..>213898
location: region:213437-213898:1
so has part: feature:213437-213898:1:exon
subclass of: SO_0000010

856752
type: Gene
SIO_000068: ncbigene

position:213437:1
position: 213437
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:213898:1
position: 213898
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:213437-213898:1:exon

YER030W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CHZ1
locus tag: YER030W
product: Chz1p
transcript id: NM_001178921.1
SIO_010081: YER030W
subclass of: SO_0000673
so part of: YER030W
location: <213437..>213898
location: region:213437-213898:1
so has part: feature:213437-213898:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:213437-213898:1:exon

YER030W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CHZ1
locus tag: YER030W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:17289584]
experiment: EXISTENCE:mutant phenotype:GO:2001168 positive regulation of histone H2B ubiquitination [PMID:20008511]
experiment: EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:17289584]
experiment: EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17289584]
note: Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
codon start: 1
product: Chz1p
translation: MSDEAKEKRELESQKESSHNKSEKSVEPKPKRRRRRNYDDYDAEVAKEETKAKNGLTKSENNGTVEDSESDMDDAKLDALMGNEGEEEEDDLAEIDTSNIITSGRRTRGKVIDYKKTAEELDKKEPSTGSKDDVGYGEKEEDDEDEEDDDFKE
SIO_010081: YER030W
subclass of: SO_0000673
so part of: YER030W
location: 213437..213898
location: region:213437-213898:1
so has part: feature:213437-213898:1:exon

NP_010947.2
type: Protein
SIO_000068: ncbiprotein

S000000832
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:213437-213898:1:exon

YER031C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YPT8
gene: YPT31
locus tag: YER031C
gene synonym: YPT8
so part of: sequence
location: complement(<214076..>214747)
location: region:214076-214747:-1
so has part: feature:214076-214747:-1:exon
subclass of: SO_0000010

856753
type: Gene
SIO_000068: ncbigene

position:214076:-1
position: 214076
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:214747:-1
position: 214747
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:214076-214747:-1:exon

YER031C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YPT8
gene: YPT31
locus tag: YER031C
gene synonym: YPT8
product: Rab family GTPase YPT31
transcript id: NM_001178922.1
SIO_010081: YER031C
subclass of: SO_0000673
so part of: YER031C
location: complement(<214076..>214747)
location: region:214076-214747:-1
so has part: feature:214076-214747:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:214076-214747:-1:exon

YER031C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YPT8
gene: YPT31
locus tag: YER031C
gene synonym: YPT8
experiment: EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]
experiment: EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:26906739]
experiment: EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:15537705]
experiment: EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9151665]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9151665]
note: Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi
codon start: 1
product: Rab family GTPase YPT31
translation: MSSEDYGYDYDLLFKIVLIGDSGVGKSNLLSRFTKNEFNMDSKSTIGVEFATRTLEIDGKRIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENCNHWLSELRENADDNVAVGLIGNKSDLAHLRAVPTEESKTFAQENQLLFTETSALNSENVDKAFEELINTIYQKVSKHQMDLGDSSANGNANGASAPNGPTISLTPTPNENKKANGNNCC
SIO_010081: YER031C
subclass of: SO_0000673
so part of: YER031C
location: complement(214076..214747)
location: region:214076-214747:-1
so has part: feature:214076-214747:-1:exon

NP_010948.1
type: Protein
SIO_000068: ncbiprotein

S000000833
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:214076-214747:-1:exon

YER032W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PIP1
gene: FIR1
locus tag: YER032W
gene synonym: PIP1
so part of: sequence
location: <215063..>217693
location: region:215063-217693:1
so has part: feature:215063-217693:1:exon
subclass of: SO_0000010

856754
type: Gene
SIO_000068: ncbigene

position:215063:1
position: 215063
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:217693:1
position: 217693
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:215063-217693:1:exon

YER032W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PIP1
gene: FIR1
locus tag: YER032W
gene synonym: PIP1
product: Fir1p
transcript id: NM_001178923.3
SIO_010081: YER032W
subclass of: SO_0000673
so part of: YER032W
location: <215063..>217693
location: region:215063-217693:1
so has part: feature:215063-217693:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:215063-217693:1:exon

YER032W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PIP1
gene: FIR1
locus tag: YER032W
gene synonym: PIP1
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006378 mRNA polyadenylation [PMID:16788068]
experiment: EXISTENCE:mutant phenotype:GO:0006378 mRNA polyadenylation [PMID:9196079]
experiment: EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:30455324]
experiment: EXISTENCE:mutant phenotype:GO:0043631 RNA polyadenylation [PMID:16788068]
note: Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate
codon start: 1
product: Fir1p
translation: MSLPVTPVKSKVCSTLSIQHEMDHDQCRDVLCPRENLLAINRTNNIESVAIPRQRSSKNKKPHEHTQSQVRFSIPDPNEISQDSPLKIVFPKSGNETERRMSTSSLLMNSHGHLVDMHSKILVDVPKEVWKFHHNRRKKCESRHRKTRSDVRSNTSSSGKEPNHSRSKSLQSIIVDTMNTYRATEVETSINENTSNISQVSPLNLSFDRPPPLTPEKNLYLTPESPLNRYHLPVPLEISLPPYLSPQNKDKKRSSLVYDGDGYSQFQEGNTSSSTESSLEQPSSSYSDEDDSIPYAHHDVSFELNNADADKLLGIDENANVNLKIQRRNLKNPQHIKSKTDRECEEKNTEKNVSLKILSTPNKLIDIPDLEHMKSPPSTGLNGTLKFFQQFEPSEEPTSPTRQVNPESLDKLDMSFKFPSSTTNNNVDKVHENRNSGDTNNEDFLKVDTSPVNQSFESRRQMLIDLQKSPTNNNPRIHKHRRSRSVHNIDDISLNFEATSTPPAPTSAPSIPVEHSNPCTSIEIPKRSPLRFTSSPKTSDIPPEAQSPKNGSFLQEISVPSIQIIPDESISHTREPSPSLIECPEDENEAFSTEVADHSIAIISETKSVPSIEPFKPLSSFNSFGQEIQNKEPTPLNQTPTDLIGKQRNCVNPHSIPFSVLSSNSQSSQSGSSKSSYNSEFSSNTAITDTTSQPSVTINRSTLEHNFIEEKRSIKNLGHGPPSQKNNYSFPRNKNTPSNRHDLDFNTIYEKRDGKMVEVILLDEDEDVGLKNNDISRTRVCHAQKAKNEQQKKRLSHCNEILGMCDKTADDAKRIIYQLVNEKHKFSEKGQQTKPKKSRVLPPLPFPLYDEKGNSLIPNKYQSSIHNDIPSHRKLK
SIO_010081: YER032W
subclass of: SO_0000673
so part of: YER032W
location: 215063..217693
location: region:215063-217693:1
so has part: feature:215063-217693:1:exon

NP_010949.4
type: Protein
SIO_000068: ncbiprotein

S000000834
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:215063-217693:1:exon

YER033C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ZRG8
locus tag: YER033C
so part of: sequence
location: complement(<218057..>221287)
location: region:218057-221287:-1
so has part: feature:218057-221287:-1:exon
subclass of: SO_0000010

856755
type: Gene
SIO_000068: ncbigene

position:218057:-1
position: 218057
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:221287:-1
position: 221287
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:218057-221287:-1:exon

YER033C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ZRG8
locus tag: YER033C
product: Zrg8p
transcript id: NM_001178924.1
SIO_010081: YER033C
subclass of: SO_0000673
so part of: YER033C
location: complement(<218057..>221287)
location: region:218057-221287:-1
so has part: feature:218057-221287:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:218057-221287:-1:exon

YER033C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ZRG8
locus tag: YER033C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:15972461]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15972461]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:15972461]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15972461]
note: hypothetical protein; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
codon start: 1
product: Zrg8p
translation: MRSFIKAHKKSTSFDESPKRHSNFSGNTNNSSQRSSDDSLDFLPSTPSQMNYDSIPPPAKHSPGFESFHRLANKTSKLFKKTSNSNLNSHLASTPTTSTNQTTSNSFVLQNPPTKNTGPPPPLPPPLFPSSSTSSFSRHDNESEYTAYKKTSPAKDFNRTTDSLPAIKGTITHSWGDSKVESHVIILNDPASPASNTSEATSSKQFKTPIIGNENLTSTTSPSNLEPAIRILNKNKGKQQENIDDAEDGSSKKEHHVYKALALAKNRNRQARIHSHDDIINLGKASQMDMSLLAAAFSGNSTTTINNDQSSNEQTDEKILDIERVTTTSTLTSSETTSPINKSPCFYSQTLSLSPKIRHGDLQSSPSKVNKNDSQNETLNKKKVRISLNRKEEEKVYSLNNNSDEYSVNEKETHKANDCNDESSENGDGDNDHDDDYDDDDDDDDDDDESEFSFEYAGINVRTSSVKYYSKPEPAANVYIDDLYEDENFDDDMNCIEDDESGNEGNEICGLSTRFEETSLKSNKVKKFNDLFNLSDDDEEEDGKDNSNNGDENESDNLYQKRLENGKETFNGNHGGHHDDASLGETVDNKEQFLINDNVKKPIQKYNDLFDLSDEDDNDDKEMSEAESYMFSDEAPSIESGPANAKSTRGIYSQSNKNIIRDGKPNYSFSLKRNNSDDETEHTSAIKASLTGTTGSTKPTVKSFSDIFNVDDSASDAESDSGTGGNNSNGLVSNDSERQVSLQSSLYETKSESHPPNHPHSQILQTPAKIVITPSVSDAQSQALAITDDDGEDDDDDTSSILRTPFQLIDSSHSQQPHYASPQYTAVLNSPPLPPPARSQSLKYHDLNCDLDSEVPRPMSNLFFIDEAEEDEYNQKSKFFDFDHYDIDEINGIPEDFNFSDSERDDLNRRTLKSPLRGGSKNREVSPFSSVSSSFRSTHSFNGKLTINQGAKELAPMKNKIELTNKTVTFFNSNNWNTYDCNSLSRKTSSQMRDSKYQNHNVGQNVEPSSVLSPQHQISNGLDGKCNDNYVISPNLPTTITPTNSFTKPTPEFSNDYSLSPIQETPSSVQSSPKRA
SIO_010081: YER033C
subclass of: SO_0000673
so part of: YER033C
location: complement(218057..221287)
location: region:218057-221287:-1
so has part: feature:218057-221287:-1:exon

NP_010950.1
type: Protein
SIO_000068: ncbiprotein

S000000835
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:218057-221287:-1:exon

YER034W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER034W
so part of: sequence
location: <221846..>222403
location: region:221846-222403:1
so has part: feature:221846-222403:1:exon
subclass of: SO_0000010

856756
type: Gene
SIO_000068: ncbigene

position:221846:1
position: 221846
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:222403:1
position: 222403
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:221846-222403:1:exon

YER034W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER034W
product: uncharacterized protein
transcript id: NM_001178925.1
SIO_010081: YER034W
subclass of: SO_0000673
so part of: YER034W
location: <221846..>222403
location: region:221846-222403:1
so has part: feature:221846-222403:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:221846-222403:1:exon

YER034W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER034W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: hypothetical protein; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MDAFSLKKDNRKKFQDKQKLKRKHATPSDRKYRLLNRQKEEKATTEEKDQDQEQPALKSNEDRYYEDPVLEDPHSAVANAELNKVLKDVLKNRLQQNDDATAVNNVANKDTLKIKDLKQMNTDELNRWLGRQNTTSAITAAEPESLVVPIHVQGDHDRAGKKISAPSTDLPEELETDQDFLDGLL
SIO_010081: YER034W
subclass of: SO_0000673
so part of: YER034W
location: 221846..222403
location: region:221846-222403:1
so has part: feature:221846-222403:1:exon

NP_010951.1
type: Protein
SIO_000068: ncbiprotein

S000000836
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:221846-222403:1:exon

YER035W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EDC2
locus tag: YER035W
so part of: sequence
location: <222639..>223076
location: region:222639-223076:1
so has part: feature:222639-223076:1:exon
subclass of: SO_0000010

856757
type: Gene
SIO_000068: ncbigene

position:222639:1
position: 222639
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:223076:1
position: 223076
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:222639-223076:1:exon

YER035W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EDC2
locus tag: YER035W
product: Edc2p
transcript id: NM_001178926.3
SIO_010081: YER035W
subclass of: SO_0000673
so part of: YER035W
location: <222639..>223076
location: region:222639-223076:1
so has part: feature:222639-223076:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:222639-223076:1:exon

YER035W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EDC2
locus tag: YER035W
experiment: EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12554867]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:12554867]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19682251|PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19682251]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:19682251]
note: RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication
codon start: 1
product: Edc2p
translation: MGSETKHSAKVKIVTRESPPSAKEHMRPTKTQILVPPTQSLPNGKKPNFGKSTKQRREPRERTSKTGHEDDKATMVTVNIDAFLHDKAPKKKSCKYKKKKTRQYQDRAAASIDSKPHVAGHTAFAGASFTTDIPHEAALPKPSFV
SIO_010081: YER035W
subclass of: SO_0000673
so part of: YER035W
location: 222639..223076
location: region:222639-223076:1
so has part: feature:222639-223076:1:exon

NP_010952.3
type: Protein
SIO_000068: ncbiprotein

S000000837
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:222639-223076:1:exon

YER036C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARB1
locus tag: YER036C
so part of: sequence
location: complement(<223367..>225199)
location: region:223367-225199:-1
so has part: feature:223367-225199:-1:exon
subclass of: SO_0000010

856758
type: Gene
SIO_000068: ncbigene

position:223367:-1
position: 223367
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:225199:-1
position: 225199
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:223367-225199:-1:exon

YER036C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARB1
locus tag: YER036C
product: ATP-binding cassette family ATPase ARB1
transcript id: NM_001178927.1
SIO_010081: YER036C
subclass of: SO_0000673
so part of: YER036C
location: complement(<223367..>225199)
location: region:223367-225199:-1
so has part: feature:223367-225199:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:223367-225199:-1:exon

YER036C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARB1
locus tag: YER036C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16260602]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:16260602]
experiment: EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16260602]
experiment: EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16260602]
experiment: EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32320318]
note: ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant
codon start: 1
product: ATP-binding cassette family ATPase ARB1
translation: MPPVSASKAKRDAKKAEREAKKAAAGKTIRKLGRKKEAAAEESEVDAAAREIKMMKLQQDKDGLSDRVVTGVLSSLETSRDIKLSSVSLLFHGKVLIQDSGLELNYGRRYGLLGENGCGKSTFLKALATREYPIPEHIDIYLLDEPAEPSELSALDYVVTEAQHELKRIEDLVEKTILEDGPESELLEPLYERMDSLDPDTFESRAAIILIGLGFNKKTILKKTKDMSGGWKMRVALAKALFVKPTLLLLDDPTAHLDLEACVWLEEYLKRFDRTLVLVSHSQDFLNGVCTNMIDMRAQKLTAYGGNYDSYHKTRSELETNQMKQYNKQQEEIQHIKKFIASAGTYANLVKQAKSRQKILDKMEADGLVQPVVPDKVFSFRFPQVERLPPPVLAFDDISFHYESNPSENLYEHLNFGVDMDSRIALVGPNGVGKSTLLKIMTGELTPQSGRVSRHTHVKLGVYSQHSQDQLDLTKSALEFVRDKYSNISQDFQFWRGQLGRYGLTGEGQTVQMATLSEGQRSRVVFALLALEQPNVLLLDEPTNGLDIPTIDSLADAINEFNGGVVVVSHDFRLLDKIAQDIFVVENKTATRWDGSILQYKNKLAKNVVL
SIO_010081: YER036C
subclass of: SO_0000673
so part of: YER036C
location: complement(223367..225199)
location: region:223367-225199:-1
so has part: feature:223367-225199:-1:exon

NP_010953.1
type: Protein
SIO_000068: ncbiprotein

S000000838
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:223367-225199:-1:exon

YER037W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PHM8
locus tag: YER037W
so part of: sequence
location: <225889..>226854
location: region:225889-226854:1
so has part: feature:225889-226854:1:exon
subclass of: SO_0000010

856759
type: Gene
SIO_000068: ncbigene

position:225889:1
position: 225889
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:226854:1
position: 226854
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:225889-226854:1:exon

YER037W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PHM8
locus tag: YER037W
product: bifunctional nucleotidase/lysophosphatidic acid phosphatase
transcript id: NM_001178928.1
SIO_010081: YER037W
subclass of: SO_0000673
so part of: YER037W
location: <225889..>226854
location: region:225889-226854:1
so has part: feature:225889-226854:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:225889-226854:1:exon

YER037W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PHM8
locus tag: YER037W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:23670538]
experiment: EXISTENCE:direct assay:GO:0052642 lysophosphatidic acid phosphatase activity [PMID:18234677]
experiment: EXISTENCE:mutant phenotype:GO:0009166 nucleotide catabolic process [PMID:23670538]
experiment: EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:18234677]
experiment: EXISTENCE:mutant phenotype:GO:0052642 lysophosphatidic acid phosphatase activity [PMID:18234677]
experiment: EXISTENCE:mutant phenotype:GO:0070328 triglyceride homeostasis [PMID:26979516]
experiment: EXISTENCE:mutant phenotype:GO:0090549 response to carbon starvation [PMID:23670538]
note: Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication
codon start: 1
product: bifunctional nucleotidase/lysophosphatidic acid phosphatase
translation: MTIAKDYRTIYRNQIKKQIRLNQEHLQSLTHLGSQINFEVDPPKLPDPDPARKVFFFDIDNTLYRKSTKVQLLMQQSLSNFFKYELGFDDDEAERLIESYYQEYGLSVKGLIKNKQIDDVLQYNTFIDDSLPLQDYLKPDWKLRELLINLKKKKLGKFDKLWLFTNSYKNHAIRCVKILGIADLFDGITYCHYDRPIEEEFICKPDPKFFETAKLQSGLSSFANAWFIDDNESNVRSALSMGMGHVIHLIEDYQYESENIVTKDHKNKQQFSILKDILEIPLIMDVEVYRPSSIAIKEMEELEEEGEAVNWSNQQINVQSS
SIO_010081: YER037W
subclass of: SO_0000673
so part of: YER037W
location: 225889..226854
location: region:225889-226854:1
so has part: feature:225889-226854:1:exon

NP_010954.1
type: Protein
SIO_000068: ncbiprotein

S000000839
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:225889-226854:1:exon

YER038C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NSE6
gene: KRE29
locus tag: YER038C
gene synonym: NSE6
so part of: sequence
location: complement(<226858..>228252)
location: region:226858-228252:-1
so has part: feature:226858-228252:-1:exon
subclass of: SO_0000010

856760
type: Gene
SIO_000068: ncbigene

position:226858:-1
position: 226858
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228252:-1
position: 228252
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:226858-228252:-1:exon

YER038C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NSE6
gene: KRE29
locus tag: YER038C
gene synonym: NSE6
product: Smc5-Smc6 complex subunit KRE29
transcript id: NM_001178929.3
SIO_010081: YER038C
subclass of: SO_0000673
so part of: YER038C
location: complement(<226858..>228252)
location: region:226858-228252:-1
so has part: feature:226858-228252:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:226858-228252:-1:exon

YER038C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NSE6
gene: KRE29
locus tag: YER038C
gene synonym: NSE6
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:34191293]
experiment: EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]
note: Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
codon start: 1
product: Smc5-Smc6 complex subunit KRE29
translation: MGSVNSSPNEEFETVPDSQISGFDSPLIPTSVGSYFRDDDDDEKVHPNFISDPENDSLNSDEEFSSLENSDLNLSGAKAESGDDFDPILKRTIISKRKAPSNNEDEEIVKTPRKLVNYVPLKIFNLGDSFDDTITTTVAKLQDLKKEILDSPRSNKSIVITSNTVAKSELQKSIKFSGSIPEIYLDVVTKETISDKYKDWHFISKNCHYEQLMDLEMKDTAYSFLFGSSRSQGKVPEFVHLKCPSITNLLVLFGVNQEKCNSLKINYEKKENSRYDNLCTIFPVNKMLKFLMYFYSDDDNDDVREFFLKAFICLILDRKVFNAMESDHRLCFKVLELFNEAHFINSYFEIVDKNDFFLHYRLLQIFPHLQSALLRRRFSEKQGRTETIQQNIIKEFNEFFDCKNYKNLLYFILTMYGSKFIPFGPKCQVTEYFKDCILDISNETTNDVEISILKGILNLFSKIR
SIO_010081: YER038C
subclass of: SO_0000673
so part of: YER038C
location: complement(226858..228252)
location: region:226858-228252:-1
so has part: feature:226858-228252:-1:exon

NP_010955.3
type: Protein
SIO_000068: ncbiprotein

S000000840
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:226858-228252:-1:exon

YER038W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP49
locus tag: YER038W-A
so part of: sequence
location: <228451..>228831
location: region:228451-228831:1
so has part: feature:228451-228831:1:exon
subclass of: SO_0000010

20098144
type: Gene
SIO_000068: ncbigene

position:228451:1
position: 228451
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:228831:1
position: 228831
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228451-228831:1:exon

YER038W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP49
locus tag: YER038W-A
product: Fmp49p
transcript id: NM_001301348.1
SIO_010081: YER038W-A
subclass of: SO_0000673
so part of: YER038W-A
location: <228451..>228831
location: region:228451-228831:1
so has part: feature:228451-228831:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228451-228831:1:exon

YER038W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP49
locus tag: YER038W-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: Mitochondrial hypothetical protein; almost completely overlaps ORF HVG1/YER039C
codon start: 1
product: Fmp49p
translation: MYYFSRVAARTFCCCIFFCLATAYSRPDRNPRKIEKKDKKFFGASKNTNPANAMGNLFKAPTIEYVVEEVTRTHQPEQYDIPTDMSPLMTIAASESADKFTDKFFVDQSSIMKEKTSSKGNARTLL
SIO_010081: YER038W-A
subclass of: SO_0000673
so part of: YER038W-A
location: 228451..228831
location: region:228451-228831:1
so has part: feature:228451-228831:1:exon

NP_001288277.1
type: Protein
SIO_000068: ncbiprotein

S000028746
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228451-228831:1:exon

YER039C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YEM9
gene: HVG1
locus tag: YER039C
gene synonym: YEM9
so part of: sequence
location: complement(<228456..>229205)
location: region:228456-229205:-1
so has part: feature:228456-229205:-1:exon
subclass of: SO_0000010

856761
type: Gene
SIO_000068: ncbigene

position:228456:-1
position: 228456
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229205:-1
position: 229205
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:228456-229205:-1:exon

YER039C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YEM9
gene: HVG1
locus tag: YER039C
gene synonym: YEM9
product: putative GDP-mannose transporter
transcript id: NM_001178930.1
SIO_010081: YER039C
subclass of: SO_0000673
so part of: YER039C
location: complement(<228456..>229205)
location: region:228456-229205:-1
so has part: feature:228456-229205:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:228456-229205:-1:exon

YER039C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YEM9
gene: HVG1
locus tag: YER039C
gene synonym: YEM9
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; HVG1 has a paralog, VRG4, that arose from the whole genome duplication
codon start: 1
product: putative GDP-mannose transporter
translation: MIYTSSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGKVTSMELTSFIMMVLSSVVATWGDQQAIAIKASSLEDLDQELVESTIFVLNPGYLWMFTNCISSALFVLIMRKRIRLTNFKDYDTMFYNNVLALPLLLVFSFIMEDWSTKNLSVNLSADSLAAMVISGLMSVGISYCSGWCVRVTSSTTYSMVGALNKLPIALAGLVFFDAPKNFLSFFSIFLGFLSGLLYAVAKQKKIQQQKVLAATLEK
SIO_010081: YER039C
subclass of: SO_0000673
so part of: YER039C
location: complement(228456..229205)
location: region:228456-229205:-1
so has part: feature:228456-229205:-1:exon

NP_010956.1
type: Protein
SIO_000068: ncbiprotein

S000000841
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:228456-229205:-1:exon

YER039C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER039C-A
so part of: sequence
location: complement(<229263..>229481)
location: region:229263-229481:-1
so has part: feature:229263-229481:-1:exon
subclass of: SO_0000010

856762
type: Gene
SIO_000068: ncbigene

position:229263:-1
position: 229263
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:229481:-1
position: 229481
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229263-229481:-1:exon

YER039C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER039C-A
product: uncharacterized protein
transcript id: NM_001184319.1
SIO_010081: YER039C-A
subclass of: SO_0000673
so part of: YER039C-A
location: complement(<229263..>229481)
location: region:229263-229481:-1
so has part: feature:229263-229481:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229263-229481:-1:exon

YER039C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER039C-A
note: hypothetical protein; YER039C-A is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MSKHKHEWTESVANSGPASILSYCASSILMTVTNKFVVNLDNFNMNFVMLFVQSLVCTVTLCILRIVGVANF
SIO_010081: YER039C-A
subclass of: SO_0000673
so part of: YER039C-A
location: complement(229263..229481)
location: region:229263-229481:-1
so has part: feature:229263-229481:-1:exon

NP_010957.1
type: Protein
SIO_000068: ncbiprotein

S000007226
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229263-229481:-1:exon

YER040W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLN3
locus tag: YER040W
so part of: sequence
location: <229795..>231987
location: region:229795-231987:1
so has part: feature:229795-231987:1:exon
subclass of: SO_0000010

856763
type: Gene
SIO_000068: ncbigene

position:229795:1
position: 229795
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:231987:1
position: 231987
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:229795-231987:1:exon

YER040W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLN3
locus tag: YER040W
product: nitrogen-responsive transcriptional regulator GLN3
transcript id: NM_001178931.3
SIO_010081: YER040W
subclass of: SO_0000673
so part of: YER040W
location: <229795..>231987
location: region:229795-231987:1
so has part: feature:229795-231987:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:229795-231987:1:exon

YER040W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLN3
locus tag: YER040W
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7608102]
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:8655543]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10604478|PMID:27293098]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12140287]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26649943]
experiment: EXISTENCE:mutant phenotype:GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter [PMID:7568152]
experiment: EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:8655543]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2153652|PMID:26649943]
experiment: EXISTENCE:mutant phenotype:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:26649943]
note: Transcriptional activator in nitrogen catabolite repression system; localization and activity regulated by quality of nitrogen source and Ure2p; full-length protein forms prion-like aggregates when overproduced
codon start: 1
product: nitrogen-responsive transcriptional regulator GLN3
translation: MQDDPENSKLYDLLNSHLDVHGRSNEEPRQTGDSRSQSSGNTGENEEDIAFASGLNGGTFDSMLEALPDDLYFTDFVSPFTAAATTSVTTKTVKDTTPATNHMDDDIAMFDSLATTQPIDIAASNQQNGEIAQLWDFNVDQFNMTPSNSSGSATISAPNSFTSDIPQYNHGSLGNSVSKSSLFPYNSSTSNSNINQPSINNNSNTNAQSHHSFNIYKLQNNNSSSSAMNITNNNNSNNSNIQHPFLKKSDSIGLSSSNTTNSVRKNSLIKPMSSTSLANFKRAASVSSSISNMEPSGQNKKPLIQCFNCKTFKTPLWRRSPEGNTLCNACGLFQKLHGTMRPLSLKSDVIKKRISKKRAKQTDPNIAQNTPSAPATASTSVTTTNAKPIRSRKKSLQQNSLSRVIPEEIIRDNIGNTNNILNVNRGGYNFNSVPSPVLMNSQSYNSSNANFNGASNANLNSNNLMRHNSNTVTPNFRRSSRRSSTSSNTSSSSKSSSRSVVPILPKPSPNSANSQQFNMNMNLMNTTNNVSAGNSVASSPRIISSANFNSNSPLQQNLLSNSFQRQGMNIPRRKMSRNASYSSSFMAASLQQLHEQQQVDVNSNTNTNSNRQNWNSSNSVSTNSRSSNFVSQKPNFDIFNTPVDSPSVSRPSSRKSHTSLLSQQLQNSESNSFISNHKFNNRLSSDSTSPIKYEADVSAGGKISEDNSTKGSSKESSAIADELDWLKFGI
SIO_010081: YER040W
subclass of: SO_0000673
so part of: YER040W
location: 229795..231987
location: region:229795-231987:1
so has part: feature:229795-231987:1:exon

NP_010958.3
type: Protein
SIO_000068: ncbiprotein

S000000842
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:229795-231987:1:exon

YER041W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YEN1
locus tag: YER041W
so part of: sequence
location: <232461..>234740
location: region:232461-234740:1
so has part: feature:232461-234740:1:exon
subclass of: SO_0000010

856764
type: Gene
SIO_000068: ncbigene

position:232461:1
position: 232461
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:234740:1
position: 234740
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:232461-234740:1:exon

YER041W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YEN1
locus tag: YER041W
product: crossover junction endodeoxyribonuclease
transcript id: NM_001178932.2
SIO_010081: YER041W
subclass of: SO_0000673
so part of: YER041W
location: <232461..>234740
location: region:232461-234740:1
so has part: feature:232461-234740:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:232461-234740:1:exon

YER041W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YEN1
locus tag: YER041W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:34928393|PMID:19520826]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]
experiment: EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:34928393]
experiment: EXISTENCE:direct assay:GO:0008821 crossover junction endodeoxyribonuclease activity [PMID:19020614]
experiment: EXISTENCE:direct assay:GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity [PMID:34928393]
experiment: EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:20106725]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:20106725]
experiment: EXISTENCE:mutant phenotype:GO:0008821 crossover junction endodeoxyribonuclease activity [PMID:19020614]
note: Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p
codon start: 1
product: crossover junction endodeoxyribonuclease
translation: MGVSQIWEFLKPYLQDSRIPLRKFVIDFNKSQKRAPRIAIDAYGWLFECGFIQNIDISARSRSRSRSPTRSPRDSDIDSSQEYYGSRSYTTTGKAVINFISRLKELLSLNVEFLLVFDGVMKPSFKRKFNHEQNATTCDDEKEYYSSWEQHVKNHEVYGNCKGLLAPSDPEFISLVRKLLDLMNISYVIACGEGEAQCVWLQVSGAVDFILSNDSDTLVFGGEKILKNYSKFYDDFGPSSITSHSPSRHHDSKESFVTVIDLPKINKVAGKKFDRLSLLFFSVLLGADYNRGVKGLGKNKSLQLAQCEDPNFSMEFYDIFKDFNLEDLTSESLRKSRYRLFQKRLYLYCKDHSVELFGRNYPVLLNQGSFEGWPSTVAIMHYFHPIVQPYFDEEVLSDKYINMAGNGHYRNLNFNELKYFLQSLNLPQISSFDKWFHDSMHEMFLLREFLSIDESDNIGKGNMRITEEKIMNIDGGKFQIPCFKIRYTTFLPNIPISSQSPLKRSNSPSRSKSPTRRQMDIMEHPNSLWLPKYLIPQSHPLVIQYYETQQLIQKEKEKKGKKSNKSRLPQKNNLDEFLRKHTSPIKSIGKVGESRKEILEPVRKRLFVDTDEDTSLEEIPAPTRLTTVDEHSDNDDDSLIFVDEITNSQSVLDSSPGKRIRDLTQDEQVDVWKDVIEISPIKKSRTTNAEKNPPESGLKSRSSITINARLQGTKMLPPNLTAPRLEREHSSVLDQLVTDAQDTVDRFVACDSDSSSTIE
SIO_010081: YER041W
subclass of: SO_0000673
so part of: YER041W
location: 232461..234740
location: region:232461-234740:1
so has part: feature:232461-234740:1:exon

NP_010959.2
type: Protein
SIO_000068: ncbiprotein

S000000843
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:232461-234740:1:exon

YER042W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MXR1
locus tag: YER042W
so part of: sequence
location: <234937..>235491
location: region:234937-235491:1
so has part: feature:234937-235491:1:exon
subclass of: SO_0000010

856765
type: Gene
SIO_000068: ncbigene

position:234937:1
position: 234937
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:235491:1
position: 235491
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:234937-235491:1:exon

YER042W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MXR1
locus tag: YER042W
product: peptide-methionine-S-sulfoxide reductase
transcript id: NM_001178933.1
SIO_010081: YER042W
subclass of: SO_0000673
so part of: YER042W
location: <234937..>235491
location: region:234937-235491:1
so has part: feature:234937-235491:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:234937-235491:1:exon

YER042W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MXR1
locus tag: YER042W
EC number: 1.8.4.11
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20799725|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008113 peptide-methionine (S)-S-oxide reductase activity [PMID:15141092|PMID:9275166]
experiment: EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:11929995]
experiment: EXISTENCE:mutant phenotype:GO:0008113 peptide-methionine (S)-S-oxide reductase activity [PMID:15141092|PMID:9275166]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11929995|PMID:9275166]
note: Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease
codon start: 1
product: peptide-methionine-S-sulfoxide reductase
translation: MSSLISKTIKYDPAKDKLITLACGCFWGTEHMYRKYLNDRIVDCKVGYANGEESKKDSPSSVSYKRVCGGDTDFAEVLQVSYNPKVITLRELTDFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQPKWGNKIATVIEPIKNFYDAEEYHQLYLDKNPQGYACPTHYLREM
SIO_010081: YER042W
subclass of: SO_0000673
so part of: YER042W
location: 234937..235491
location: region:234937-235491:1
so has part: feature:234937-235491:1:exon

NP_010960.1
type: Protein
SIO_000068: ncbiprotein

S000000844
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:234937-235491:1:exon

YER043C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SAH1
locus tag: YER043C
so part of: sequence
location: complement(<235770..>237119)
location: region:235770-237119:-1
so has part: feature:235770-237119:-1:exon
subclass of: SO_0000010

856766
type: Gene
SIO_000068: ncbigene

position:235770:-1
position: 235770
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:237119:-1
position: 237119
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:235770-237119:-1:exon

YER043C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SAH1
locus tag: YER043C
product: adenosylhomocysteinase
transcript id: NM_001178934.3
SIO_010081: YER043C
subclass of: SO_0000673
so part of: YER043C
location: complement(<235770..>237119)
location: region:235770-237119:-1
so has part: feature:235770-237119:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:235770-237119:-1:exon

YER043C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SAH1
locus tag: YER043C
EC number: 3.3.1.1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:0004013 adenosylhomocysteinase activity [PMID:18591246]
experiment: EXISTENCE:mutant phenotype:GO:0006641 triglyceride metabolic process [PMID:18591246]
experiment: EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:18591246]
experiment: EXISTENCE:mutant phenotype:GO:0019510 S-adenosylhomocysteine catabolic process [PMID:18591246]
note: S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels
codon start: 1
product: adenosylhomocysteinase
translation: MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY
SIO_010081: YER043C
subclass of: SO_0000673
so part of: YER043C
location: complement(235770..237119)
location: region:235770-237119:-1
so has part: feature:235770-237119:-1:exon

NP_010961.3
type: Protein
SIO_000068: ncbiprotein

S000000845
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:235770-237119:-1:exon

YER044C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BUD18
gene: ERG28
locus tag: YER044C
gene synonym: BUD18
so part of: sequence
location: complement(<237570..>238016)
location: region:237570-238016:-1
so has part: feature:237570-238016:-1:exon
subclass of: SO_0000010

856767
type: Gene
SIO_000068: ncbigene

position:237570:-1
position: 237570
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:238016:-1
position: 238016
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:237570-238016:-1:exon

YER044C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BUD18
gene: ERG28
locus tag: YER044C
gene synonym: BUD18
product: Erg28p
transcript id: NM_001178935.1
SIO_010081: YER044C
subclass of: SO_0000673
so part of: YER044C
location: complement(<237570..>238016)
location: region:237570-238016:-1
so has part: feature:237570-238016:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:237570-238016:-1:exon

YER044C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BUD18
gene: ERG28
locus tag: YER044C
gene synonym: BUD18
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]
experiment: EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:11160377]
experiment: EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:10929718|PMID:29319811]
experiment: EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:12119386|PMID:15522820]
note: Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
codon start: 1
product: Erg28p
translation: MFSLQDVITTTKTTLAAMPKGYLPKWLLFISIVSVFNSIQTYVSGLELTRKVYERKPTETTHLSARTFGTWTFISCVIRFYGAMYLNEPHIFELVFMSYMVALFHFGSELLIFRTCKLGKGFMGPLVVSTTSLVWMYKQREYYTGVAW
SIO_010081: YER044C
subclass of: SO_0000673
so part of: YER044C
location: complement(237570..238016)
location: region:237570-238016:-1
so has part: feature:237570-238016:-1:exon

NP_010962.1
type: Protein
SIO_000068: ncbiprotein

S000000846
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:237570-238016:-1:exon

YER044C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MEI4
locus tag: YER044C-A
so part of: sequence
location: complement(<238460..>239774)
location: region:238460-239774:-1
so has part: feature:238460-239774:-1:exon
subclass of: SO_0000010

856768
type: Gene
SIO_000068: ncbigene

position:238460:-1
position: 238460
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:239774:-1
position: 239774
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:238460-239774:-1:exon

YER044C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MEI4
locus tag: YER044C-A
product: Mei4p
transcript id: NM_001180023.1
SIO_010081: YER044C-A
subclass of: SO_0000673
so part of: YER044C-A
location: complement(join(<238460..239623,239712..>239774))
location: region:238460-239774:-1
so has part: feature:239712-239774:-1:exon
so has part: feature:238460-239623:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:239712-239774:-1:exon

position:239712:-1
position: 239712
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:238460-239623:-1:exon

position:239623:-1
position: 239623
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER044C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MEI4
locus tag: YER044C-A
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16783010|PMID:17558514]
experiment: EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:10224247]
note: Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores
codon start: 1
product: Mei4p
translation: MSRGKLEDMEQKETSEVDWIICFALIQSRNPTLWKRALSRKKGDVEDVGALKSEKNLKINPRENSKHIYKWVAPFENGFLNNKSLFAHLEPIYNFLCQNKYKSFEDAVGLKELQSFSKDVSTADINNWFLPRYKILLKILSLKTKEIDFRGLSQVFQTLQILLVSHYSHRIDSDSSFKRTLIDVHVFNFIAKFLFNRILLKKNQNDPKWLQNFYDQGDGKHLCDKVDYKRLCSLHFTLIYSIINIQLIKIKTNQTFEPQILKYVSVLKLIEHILIIIESLIHVLIRFVSKHKLICINRKKAYCRVYLERELSLKKTYLKNFYSVISGVPEKELGGLLKILKIVILSLLETFESIEWQHLKPFLEKFPAHEISLQKKRKYIQAALLITAERNLIARFRLSRWFNETENI
SIO_010081: YER044C-A
subclass of: SO_0000673
so part of: YER044C-A
location: complement(join(238460..239623,239712..239774))
location: region:238460-239774:-1
so has part: feature:239712-239774:-1:exon
so has part: feature:238460-239623:-1:exon

NP_010963.1
type: Protein
SIO_000068: ncbiprotein

S000001954
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:239712-239774:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:238460-239623:-1:exon

YER045C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ACA1
locus tag: YER045C
so part of: sequence
location: complement(<240032..>241501)
location: region:240032-241501:-1
so has part: feature:240032-241501:-1:exon
subclass of: SO_0000010

856769
type: Gene
SIO_000068: ncbigene

position:240032:-1
position: 240032
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:241501:-1
position: 241501
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:240032-241501:-1:exon

YER045C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ACA1
locus tag: YER045C
product: Aca1p
transcript id: NM_001178936.3
SIO_010081: YER045C
subclass of: SO_0000673
so part of: YER045C
location: complement(<240032..>241501)
location: region:240032-241501:-1
so has part: feature:240032-241501:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:240032-241501:-1:exon

YER045C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ACA1
locus tag: YER045C
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10825197]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10825197]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:10825197]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10825197]
note: ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
codon start: 1
product: Aca1p
translation: MDYKHNFATSPDSFLDGRQNPLLYTDFLSSNKELIYKQPSGPGLVDSAYNFHHQNSLHDRSVQENLGPMFQPFGVDISHLPITNPPIFQSSLPAFDQPVYKRRISISNGQISQLGEDLETVENLYNCQPPILSSKAQQNPNPQQVANPSAAIYPSFSSNELQNVPQPHEQATVIPEAAPQTGSKNIYAAMTPYDSNIKLNIPAVAATCDIPSATPSIPSGDSTMNQAYINMQLRLQAQMQTKAWKNAQLNVHPCTPASNSSVSSSSSCQNINDHNIENQSVHSSISHGVNHHTVNNSCQNAELNISSSLPYESKCPDVNLTHANSKPQYKDATSALKNNINSEKDVHTAPFSSMHTTATFQIKQEARPQKIENNTAGLKDGAKAWKRARLLERNRIAASKCRQRKKMSQLQLQREFDQISKENTMMKKKIENYEKLVQKMKKISRLHMQECTINGGNNSYQSLQNKDSDVNGFLKMIEEMIRSSSLYDE
SIO_010081: YER045C
subclass of: SO_0000673
so part of: YER045C
location: complement(240032..241501)
location: region:240032-241501:-1
so has part: feature:240032-241501:-1:exon

NP_010964.3
type: Protein
SIO_000068: ncbiprotein

S000000847
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:240032-241501:-1:exon

YER046W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPO73
locus tag: YER046W
so part of: sequence
location: <243180..>243611
location: region:243180-243611:1
so has part: feature:243180-243611:1:exon
subclass of: SO_0000010

856770
type: Gene
SIO_000068: ncbigene

position:243180:1
position: 243180
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:243611:1
position: 243611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243180-243611:1:exon

YER046W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPO73
locus tag: YER046W
product: Spo73p
transcript id: NM_001178937.1
SIO_010081: YER046W
subclass of: SO_0000673
so part of: YER046W
location: <243180..>243611
location: region:243180-243611:1
so has part: feature:243180-243611:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243180-243611:1:exon

YER046W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPO73
locus tag: YER046W
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:26605945|PMID:27303688]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15590821]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]
experiment: EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:26605945|PMID:27303688]
note: Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein
codon start: 1
product: Spo73p
translation: MGKNHFLKDFSALPEDVLIENERGITLLGYPLFSPKILLPHVDPPQFQRLNTENGSLIALSKNTISNFIELYPIDLSTERTAGSSSSQMTKWFVLMDYKEKYDIDDQGWCYSWNFNNSRWKSKNGLVRRRVWVRLPTTSHGLD
SIO_010081: YER046W
subclass of: SO_0000673
so part of: YER046W
location: 243180..243611
location: region:243180-243611:1
so has part: feature:243180-243611:1:exon

NP_010965.1
type: Protein
SIO_000068: ncbiprotein

S000000848
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243180-243611:1:exon

YER047C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SAP1
locus tag: YER047C
so part of: sequence
location: complement(<243810..>246503)
location: region:243810-246503:-1
so has part: feature:243810-246503:-1:exon
subclass of: SO_0000010

856771
type: Gene
SIO_000068: ncbigene

position:243810:-1
position: 243810
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:246503:-1
position: 246503
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:243810-246503:-1:exon

YER047C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SAP1
locus tag: YER047C
product: putative AAA family ATPase SAP1
transcript id: NM_001178938.1
SIO_010081: YER047C
subclass of: SO_0000673
so part of: YER047C
location: complement(<243810..>246503)
location: region:243810-246503:-1
so has part: feature:243810-246503:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:243810-246503:-1:exon

YER047C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SAP1
locus tag: YER047C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system
codon start: 1
product: putative AAA family ATPase SAP1
translation: MDSQRSHHILTRLTKIRRRPQQPLTDFTELYSRIANETIYYLNLEEKKRYKEALQGWKALTTDVLFKQTLIEHNYPNTQSYTKDEVSLQNGIRELYHKSVMHLKRVKKLVREEPAPRNDMPSSKTYTNHSSSFTRSTEPPPVFQMVPGRMMKTLRNRNACGYKTAYSNPSLSSYGNSTSIKRGEDAENIRVNFVPSKPLSNNASRQHKNPIEHNDPPLKKETELYSDKYISEPILIDLTNDEDDHDVGILKGHNVFDEEESDGFEFDVSDYYDNFSEVDVEEEEEEKEERRRIKTLEAIQQQMSDLSVTSSTSSNKSVSSSENVPGSCIQSLPTTAPALPSLPPPPLLNVDRASSTGALKPHSLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKSTPTLITKSTPTFITRSKSNTKPIIKSNASSPTSSLTVPNSVIQKPKTAAMAAKRVLNSKKVASNPALNTTKKSHPILKSKTAKVPNSSSKKTSSHPSRPVSNSKPYSHGASQNKKPSKNQTTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEPEIDKKVLREILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFLRPDLFRGLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLPEDQTRHVQFKKLLSHQKHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDLGDKLLETEREMIRPIGLVDFKNSLVYIKPSVSQDGLVKYEKWASQFGSSGS
SIO_010081: YER047C
subclass of: SO_0000673
so part of: YER047C
location: complement(243810..246503)
location: region:243810-246503:-1
so has part: feature:243810-246503:-1:exon

NP_010966.1
type: Protein
SIO_000068: ncbiprotein

S000000849
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:243810-246503:-1:exon

YER048C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CAJ1
locus tag: YER048C
so part of: sequence
location: complement(<246982..>248157)
location: region:246982-248157:-1
so has part: feature:246982-248157:-1:exon
subclass of: SO_0000010

856772
type: Gene
SIO_000068: ncbigene

position:246982:-1
position: 246982
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:248157:-1
position: 248157
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:246982-248157:-1:exon

YER048C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CAJ1
locus tag: YER048C
product: Caj1p
transcript id: NM_001178939.3
SIO_010081: YER048C
subclass of: SO_0000673
so part of: YER048C
location: complement(<246982..>248157)
location: region:246982-248157:-1
so has part: feature:246982-248157:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:246982-248157:-1:exon

YER048C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CAJ1
locus tag: YER048C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:32777224]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32777224]
note: Nuclear type II J heat shock protein of the E. coli dnaJ family; overexpression stabilizes amino acid permeases; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein localizes to the nucleus
codon start: 1
product: Caj1p
translation: MVKETEYYDILGIKPEATPTEIKKAYRRKAMETHPDKHPDDPDAQAKFQAVGEAYQVLSDPGLRSKYDQFGKEDAVPQQGFEDASEYFTAIFGGDGFKDWIGEFSLFKELNEATEMFGKEDEEGTAATETEKADESTDGGMVKHDTNKAESLKKDKLSKEQREKLMEMEKKRREDMMKQVDELAEKLNEKISRYLIAVKSNNLEEFTRKLDQEIEDLKLESFGLELLYLLARVYKTKANNFIMSKKTYGISKIFTGTRDNARSVKSAYNLLSTGLEAQKAMEKMSEVNTDELDQYERAKFESTMAGKALGVMWAMSKFELERKLKDVCNKILNDKKVPSKERIAKAKAMLFIAHKFASARRSPEEAEEARVFEELILGEQEKEHKKHTVAR
SIO_010081: YER048C
subclass of: SO_0000673
so part of: YER048C
location: complement(246982..248157)
location: region:246982-248157:-1
so has part: feature:246982-248157:-1:exon

NP_010967.3
type: Protein
SIO_000068: ncbiprotein

S000000850
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:246982-248157:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(249109..249331)
location: region:249109-249331:-1
so has part: feature:249109-249331:-1:region

S000006893
type: SGD
SIO_000068: sgd

position:249109:-1
position: 249109
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:249331:-1
position: 249331
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:249109-249331:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 249445..249752
location: region:249445-249752:1
so has part: feature:249445-249752:1:region

S000006913
type: SGD
SIO_000068: sgd

position:249445:1
position: 249445
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:249752:1
position: 249752
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:249445-249752:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(249930..250270)
location: region:249930-250270:-1
so has part: feature:249930-250270:-1:region

S000006904
type: SGD
SIO_000068: sgd

position:249930:-1
position: 249930
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:250270:-1
position: 250270
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:249930-250270:-1:region

YNCE0014W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0014W
so part of: sequence
location: 250286..250357
location: region:250286-250357:1
so has part: feature:250286-250357:1:exon
subclass of: SO_0000663

856773
type: Gene
SIO_000068: ncbigene

position:250286:1
position: 250286
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:250357:1
position: 250357
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:250286-250357:1:exon

YNCE0014W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0014W
product: tRNA-Gln
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]
note: Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCE0014W
subclass of: SO_0000673
so part of: YNCE0014W
location: 250286..250357
location: region:250286-250357:1
so has part: feature:250286-250357:1:exon

S000006696
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:250286-250357:1:exon

YER048W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ISD11
locus tag: YER048W-A
so part of: sequence
location: <250718..>251002
location: region:250718-251002:1
so has part: feature:250718-251002:1:exon
subclass of: SO_0000010

856774
type: Gene
SIO_000068: ncbigene

position:250718:1
position: 250718
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:251002:1
position: 251002
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:250718-251002:1:exon

YER048W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ISD11
locus tag: YER048W-A
product: Isd11p
transcript id: NM_001184330.1
SIO_010081: YER048W-A
subclass of: SO_0000673
so part of: YER048W-A
location: <250718..>251002
location: region:250718-251002:1
so has part: feature:250718-251002:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:250718-251002:1:exon

YER048W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ISD11
locus tag: YER048W-A
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:16341089|PMID:16341090]
experiment: EXISTENCE:direct assay:GO:0031071 cysteine desulfurase activity [PMID:24045011]
experiment: EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:16341089|PMID:16341090]
experiment: EXISTENCE:physical interaction:GO:0016226 iron-sulfur cluster assembly [PMID:16341090]
experiment: EXISTENCE:physical interaction:GO:1990221 L-cysteine desulfurase complex [PMID:24045011]
note: Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family
codon start: 1
product: Isd11p
translation: MPGFTAPTRRQVLSLYKEFIKNANQFNNYNFREYFLSKTRTTFRKNMNQQDPKVLMNLFKEAKNDLGVLKRQSVISQMYTFDRLVVEPLQGRKH
SIO_010081: YER048W-A
subclass of: SO_0000673
so part of: YER048W-A
location: 250718..251002
location: region:250718-251002:1
so has part: feature:250718-251002:1:exon

NP_010968.1
type: Protein
SIO_000068: ncbiprotein

S000007237
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:250718-251002:1:exon

YER049W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TPA1
locus tag: YER049W
so part of: sequence
location: <251728..>253662
location: region:251728-253662:1
so has part: feature:251728-253662:1:exon
subclass of: SO_0000010

856775
type: Gene
SIO_000068: ncbigene

position:251728:1
position: 251728
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:253662:1
position: 253662
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:251728-253662:1:exon

YER049W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TPA1
locus tag: YER049W
product: oxidative DNA demethylase
transcript id: NM_001178940.1
SIO_010081: YER049W
subclass of: SO_0000673
so part of: YER049W
location: <251728..>253662
location: region:251728-253662:1
so has part: feature:251728-253662:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:251728-253662:1:exon

YER049W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TPA1
locus tag: YER049W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:20040577]
experiment: EXISTENCE:direct assay:GO:0018188 peptidyl-proline di-hydroxylation [PMID:24550462|PMID:31320474]
experiment: EXISTENCE:direct assay:GO:0031543 peptidyl-proline dioxygenase activity [PMID:24550462|PMID:31320474]
experiment: EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16809762]
experiment: EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:24550462|PMID:16809762|PMID:20630870]
experiment: EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:24550462]
experiment: EXISTENCE:mutant phenotype:GO:0008198 ferrous iron binding [PMID:25381260]
note: Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1
codon start: 1
product: oxidative DNA demethylase
translation: MKRKTAEVKGEKERNSKQISLEEDKIKGMFNPKIWDKTFQDGLKKEIEDSQPYNWGTIHELVNDDLLRAVRKEIETEIHFTKKETDIYRVNQSGDLANLSGLDWDDLSRLPNLFKLRQILYSKQYRDFFGYVTKAGKLSGSKTDMSINTYTKGCHLLTHDDVIGSRRISFILYLPDPDRKWKSHYGGGLRLFPSILPNVPHSDPSAKLVPQFNQIAFFKVLPGFSFHDVEEVKVDKHRLSIQGWYHIPQVGEEGYIPGEEEAWVRNNTSTLAQIESNVLEDFEFPKDERNILSFHEVKHFEKMLKGDAGAKTDNTPKESMTSVISDSVKLSEAEFTYLSQYISPEHLSSKGIEKLQKQFVENSSLQIESFLNDDKSELLKKVIKQKELEQECPYHSKDVKAPWKTAIPPHKARYLYIDGKEYRNFQTEADILEALNNNDLPNFQFTKDAIKIISDASGNSRENNFDAELALIDLAVFHKSTIFKKYLALLTSLCPVSEQILIRRFRPGMDFTLATKCRFNELLKSNPDIIDAVLEGTLCLTPSAGWESGELGGYELYMMDDDEDNKQYLKEDVEDASVYRADDSGDSVLINDPPAWNTFNLVLRDESVLEFVKYVSWSAKSSRWDVKMKWDVKSCDEDGQEDEA
SIO_010081: YER049W
subclass of: SO_0000673
so part of: YER049W
location: 251728..253662
location: region:251728-253662:1
so has part: feature:251728-253662:1:exon

NP_010969.1
type: Protein
SIO_000068: ncbiprotein

S000000851
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:251728-253662:1:exon

YER050C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: bS18m
gene: RSM18
locus tag: YER050C
gene synonym: bS18m
so part of: sequence
location: complement(<253971..>254387)
location: region:253971-254387:-1
so has part: feature:253971-254387:-1:exon
subclass of: SO_0000010

856776
type: Gene
SIO_000068: ncbigene

position:253971:-1
position: 253971
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:254387:-1
position: 254387
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:253971-254387:-1:exon

YER050C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: bS18m
gene: RSM18
locus tag: YER050C
gene synonym: bS18m
product: mitochondrial 37S ribosomal protein RSM18
transcript id: NM_001178941.3
SIO_010081: YER050C
subclass of: SO_0000673
so part of: YER050C
location: complement(<253971..>254387)
location: region:253971-254387:-1
so has part: feature:253971-254387:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:253971-254387:-1:exon

YER050C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: bS18m
gene: RSM18
locus tag: YER050C
gene synonym: bS18m
experiment: EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]
note: Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein
codon start: 1
product: mitochondrial 37S ribosomal protein RSM18
translation: MQPIIKGAVSSTFKRALYNFGIKEKKSVNIEMGRTQQTKKIDQSLSKKLPKGTIYDPFDFSMGRIHLDRKYQANKNSNRNDIMKSGANPLEFYARPRILSRYVTSTGRIQHRDITGLSAKNQRRLSKAIRRCQAIGLM
SIO_010081: YER050C
subclass of: SO_0000673
so part of: YER050C
location: complement(253971..254387)
location: region:253971-254387:-1
so has part: feature:253971-254387:-1:exon

NP_010970.4
type: Protein
SIO_000068: ncbiprotein

S000000852
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:253971-254387:-1:exon

YER051W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KDM2
gene: JHD1
locus tag: YER051W
gene synonym: KDM2
so part of: sequence
location: <254656..>256134
location: region:254656-256134:1
so has part: feature:254656-256134:1:exon
subclass of: SO_0000010

856777
type: Gene
SIO_000068: ncbigene

position:254656:1
position: 254656
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:256134:1
position: 256134
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:254656-256134:1:exon

YER051W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KDM2
gene: JHD1
locus tag: YER051W
gene synonym: KDM2
product: [Histone H3]-lysine-36 demethylase
transcript id: NM_001178942.1
SIO_010081: YER051W
subclass of: SO_0000673
so part of: YER051W
location: <254656..>256134
location: region:254656-256134:1
so has part: feature:254656-256134:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:254656-256134:1:exon

YER051W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KDM2
gene: JHD1
locus tag: YER051W
gene synonym: KDM2
EC number: 1.14.11.27
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:17142463]
experiment: EXISTENCE:direct assay:GO:0051864 histone H3K36 demethylase activity [PMID:16362057]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:17525156]
experiment: EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17369256]
note: JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
codon start: 1
product: [Histone H3]-lysine-36 demethylase
translation: MQDPNICQHCQLKDNPGALIWVKCDSCPQWVHVKCVPLKRIHYSNLTSSEVLSYPNSAKQIKSYRCPNHKEGEYLTAYALITQKGKRQRNKENPEDSHINKRYNFRKKKLLDYIALNEGESKRDKMNHPHKESFMKSFEKWKNGSNIINAADFAEKFDNIDVPYKIIDPLNSGVYVPNVGTDNGCLTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEYFTNTEPDRRDRIRNVISLEVSNIEGLELERPTAVRQNDLVDKIWSFNGHLEKVNGEKAEENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEWSLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLETHLKIVEIEKLTKVPRRFTFPKFDQVMGKLCEYLALDKNKITSDVSDGDLLSRTTNCAIQSLHAYVIKPEVKYKPLNFTSKKHLAKALADLIS
SIO_010081: YER051W
subclass of: SO_0000673
so part of: YER051W
location: 254656..256134
location: region:254656-256134:1
so has part: feature:254656-256134:1:exon

NP_010971.1
type: Protein
SIO_000068: ncbiprotein

S000000853
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:254656-256134:1:exon

YER052C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BOR1
alternative label: SIL4
alternative label: THR3
gene: HOM3
locus tag: YER052C
gene synonym: BOR1; SIL4; THR3
so part of: sequence
location: complement(<256375..>257958)
location: region:256375-257958:-1
so has part: feature:256375-257958:-1:exon
subclass of: SO_0000010

856778
type: Gene
SIO_000068: ncbigene

position:256375:-1
position: 256375
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:257958:-1
position: 257958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:256375-257958:-1:exon

YER052C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BOR1
alternative label: SIL4
alternative label: THR3
gene: HOM3
locus tag: YER052C
gene synonym: BOR1; SIL4; THR3
product: aspartate kinase
transcript id: NM_001178943.1
SIO_010081: YER052C
subclass of: SO_0000673
so part of: YER052C
location: complement(<256375..>257958)
location: region:256375-257958:-1
so has part: feature:256375-257958:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:256375-257958:-1:exon

YER052C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BOR1
alternative label: SIL4
alternative label: THR3
gene: HOM3
locus tag: YER052C
gene synonym: BOR1; SIL4; THR3
EC number: 2.7.2.4
experiment: EXISTENCE:direct assay:GO:0004072 aspartate kinase activity [PMID:18626862]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0009088 threonine biosynthetic process [PMID:18626862]
experiment: EXISTENCE:mutant phenotype:GO:0004072 aspartate kinase activity [PMID:18626862]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:4380684]
experiment: EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:4380684|PMID:18626862]
experiment: EXISTENCE:mutant phenotype:GO:0009090 homoserine biosynthetic process [PMID:4380684]
note: Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
codon start: 1
product: aspartate kinase
translation: MPMDFQPTSSHSNWVVQKFGGTSVGKFPVQIVDDIVKHYSKPDGPNNNVAVVCSARSSYTKAEGTTSRLLKCCDLASQESEFQDIIEVIRQDHIDNADRFILNPALQAKLVDDTNKELELVKKYLNASKVLGEVSSRTVDLVMSCGEKLSCLFMTALCNDRGCKAKYVDLSHIVPSDFSASALDNSFYTFLVQALKEKLAPFVSAKERIVPVFTGFFGLVPTGLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRKVPEARLLDSVTPEEASELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDNVAKKGESTPPHPPENLSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTILDKYKLVVDLISTSEVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITKKLSIVSLVGKHMKQYIGIAGTMFTTLAEEGINIEMISQGANEINISCVINESDSIKALQCIHAKLLSERTNTSNQFEHAIDERLEQLKRLGI
SIO_010081: YER052C
subclass of: SO_0000673
so part of: YER052C
location: complement(256375..257958)
location: region:256375-257958:-1
so has part: feature:256375-257958:-1:exon

NP_010972.1
type: Protein
SIO_000068: ncbiprotein

S000000854
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:256375-257958:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS513; Autonomously Replicating Sequence
so part of: sequence
location: 257958..258737
location: region:257958-258737:1
so has part: feature:257958-258737:1:region

S000077385
type: SGD
SIO_000068: sgd

position:257958:1
position: 257958
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:258737:1
position: 258737
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:257958-258737:1:region

YER053C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PIC2
locus tag: YER053C
so part of: sequence
location: complement(<258737..>259639)
location: region:258737-259639:-1
so has part: feature:258737-259639:-1:exon
subclass of: SO_0000010

856779
type: Gene
SIO_000068: ncbigene

position:258737:-1
position: 258737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:259639:-1
position: 259639
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:258737-259639:-1:exon

YER053C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PIC2
locus tag: YER053C
product: Cu/Pi carrier
transcript id: NM_001178944.3
SIO_010081: YER053C
subclass of: SO_0000673
so part of: YER053C
location: complement(<258737..>259639)
location: region:258737-259639:-1
so has part: feature:258737-259639:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:258737-259639:-1:exon

YER053C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PIC2
locus tag: YER053C
experiment: EXISTENCE:direct assay:GO:0005315 inorganic phosphate transmembrane transporter activity [PMID:14756774]
experiment: EXISTENCE:direct assay:GO:0005375 copper ion transmembrane transporter activity [PMID:23846699]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14756774|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0035434 copper ion transmembrane transport [PMID:23846699]
experiment: EXISTENCE:direct assay:GO:0035435 phosphate ion transmembrane transport [PMID:14756774]
experiment: EXISTENCE:mutant phenotype:GO:0006878 cellular copper ion homeostasis [PMID:23846699]
note: Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
codon start: 1
product: Cu/Pi carrier
translation: MESNKQPRKIQLYTKEFYATCTLGGIIACGPTHSSITPLDLVKCRLQVNPKLYTSNLQGFRKIIANEGWKKVYTGFGATFVGYSLQGAGKYGGYEYFKHLYSSWLSPGVTVYLMASATAEFLADIMLCPFEAIKVKQQTTMPPFCNNVVDGWKKMYAESGGMKAFYKGIVPLWCRQIPYTMCKFTSFEKIVQKIYSVLPKKKEEMNALQQISVSFVGGYLAGILCAAVSHPADVMVSKINSERKANESMSVASKRIYQKIGFTGLWNGLMVRIVMIGTLTSFQWLIYDSFKAYVGLPTTG
SIO_010081: YER053C
subclass of: SO_0000673
so part of: YER053C
location: complement(258737..259639)
location: region:258737-259639:-1
so has part: feature:258737-259639:-1:exon

NP_010973.3
type: Protein
SIO_000068: ncbiprotein

S000000855
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:258737-259639:-1:exon

YER053C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER053C-A
so part of: sequence
location: complement(<260933..>261046)
location: region:260933-261046:-1
so has part: feature:260933-261046:-1:exon
subclass of: SO_0000010

856780
type: Gene
SIO_000068: ncbigene

position:260933:-1
position: 260933
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:261046:-1
position: 261046
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:260933-261046:-1:exon

YER053C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER053C-A
product: uncharacterized protein
transcript id: NM_001184444.1
SIO_010081: YER053C-A
subclass of: SO_0000673
so part of: YER053C-A
location: complement(<260933..>261046)
location: region:260933-261046:-1
so has part: feature:260933-261046:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:260933-261046:-1:exon

YER053C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER053C-A
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]
note: hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
codon start: 1
product: uncharacterized protein
translation: MQDLEIFLSIFAFIFVFYFGAHRTVMNRNKSDVPYLQ
SIO_010081: YER053C-A
subclass of: SO_0000673
so part of: YER053C-A
location: complement(260933..261046)
location: region:260933-261046:-1
so has part: feature:260933-261046:-1:exon

NP_061492.1
type: Protein
SIO_000068: ncbiprotein

S000007523
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:260933-261046:-1:exon

YER054C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GIP2
locus tag: YER054C
so part of: sequence
location: complement(<262052..>263698)
location: region:262052-263698:-1
so has part: feature:262052-263698:-1:exon
subclass of: SO_0000010

856781
type: Gene
SIO_000068: ncbigene

position:262052:-1
position: 262052
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:263698:-1
position: 263698
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:262052-263698:-1:exon

YER054C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GIP2
locus tag: YER054C
product: Gip2p
transcript id: NM_001178945.1
SIO_010081: YER054C
subclass of: SO_0000673
so part of: YER054C
location: complement(<262052..>263698)
location: region:262052-263698:-1
so has part: feature:262052-263698:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:262052-263698:-1:exon

YER054C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GIP2
locus tag: YER054C
experiment: EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:8754819]
experiment: EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:11973298]
experiment: EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:8754819]
note: Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication
codon start: 1
product: Gip2p
translation: MYIKAEQKPQQFERKNEKLDRNKNQQLPDLETDFKGYRVNSDLYNKERDGSTEETLNSLKFLHKPQRVTQMRANRFPEEEVQRNTDLNKRIFSAGNDENVDNESGWSKIAAAKNHTSVESLNGSTRPPFKIELPPLSPKSTVPKSFQAEYPEAKSPGNDMNFEYDEEILIPFAPPVYKKSGELLKSSLKRRSKSLPTTPGIRSGNGVQARDGSPMLIRSKSVHFDQAAPVKYFAEDESPINVNKTEQHDNCLSFKHKPVNLMVDPEEETKMLSSGLETTSIDDDLTTVAPKGFAHPAKISNPNNGKGTNNTKLRKSKRFQNLLKNRTDMPPSKSNKKFVNGGGAHEISDRNSKNYHVVGLYSKNFPILSNKNPKSLKLNIFINLSQNKKVFLQELSLYIHRDNNYFSNSSSFYNIPNSHNGNDCNGVAKGYNAGCTRLIAGRILVKNIFYDKRVVVRYTWDSWRTTHEVECVYISDGDGILPGTNMDIFHFIIDDVSKVDPRGKLEFCIHYSTRNDYEREEYWDNNNGNNYKVDVVMDGFNDPFAAAA
SIO_010081: YER054C
subclass of: SO_0000673
so part of: YER054C
location: complement(262052..263698)
location: region:262052-263698:-1
so has part: feature:262052-263698:-1:exon

NP_010974.1
type: Protein
SIO_000068: ncbiprotein

S000000856
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:262052-263698:-1:exon

YER055C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: HIS1
locus tag: YER055C
so part of: sequence
location: complement(<264892..>265785)
location: region:264892-265785:-1
so has part: feature:264892-265785:-1:exon
subclass of: SO_0000010

856782
type: Gene
SIO_000068: ncbigene

position:264892:-1
position: 264892
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:265785:-1
position: 265785
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:264892-265785:-1:exon

YER055C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: HIS1
locus tag: YER055C
product: ATP phosphoribosyltransferase
transcript id: NM_001178946.3
SIO_010081: YER055C
subclass of: SO_0000673
so part of: YER055C
location: complement(<264892..>265785)
location: region:264892-265785:-1
so has part: feature:264892-265785:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:264892-265785:-1:exon

YER055C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: HIS1
locus tag: YER055C
EC number: 2.4.2.17
experiment: EXISTENCE:mutant phenotype:GO:0000105 histidine biosynthetic process [PMID:14190241]
experiment: EXISTENCE:mutant phenotype:GO:0003879 ATP phosphoribosyltransferase activity [PMID:14190241]
note: ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
codon start: 1
product: ATP phosphoribosyltransferase
translation: MDLVNHLTDRLLFAIPKKGRLYSKSVSILNGADITFHRSQRLDIALSTSLPVALVFLPAADIPTFVGEGKCDLGITGVDQVRESNVDVDLAIDLQFGNCKLQVQVPVNGEYKKPEQLIGKTIVTSFVKLAEKYFADLEGTTVEKMTTRIKFVSGSVEASCALGIGDAIVDLVESGETMRAAGLVDIATVLSTSAYLIESKNPKSDKSLIATIKSRIEGVMTAQRFVSCIYNAPEDKLPELLKVTPGRRAPTISKIDDEGWVAVSSMIERKTKGVVLDELKRLGASDIMVFEISNCRV
SIO_010081: YER055C
subclass of: SO_0000673
so part of: YER055C
location: complement(264892..265785)
location: region:264892-265785:-1
so has part: feature:264892-265785:-1:exon

NP_010975.3
type: Protein
SIO_000068: ncbiprotein

S000000857
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:264892-265785:-1:exon

YER056C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BRA7
gene: FCY2
locus tag: YER056C
gene synonym: BRA7
so part of: sequence
location: complement(<266512..>268113)
location: region:266512-268113:-1
so has part: feature:266512-268113:-1:exon
subclass of: SO_0000010

856783
type: Gene
SIO_000068: ncbigene

position:266512:-1
position: 266512
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:268113:-1
position: 268113
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:266512-268113:-1:exon

YER056C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BRA7
gene: FCY2
locus tag: YER056C
gene synonym: BRA7
product: purine-cytosine permease
transcript id: NM_001178947.1
SIO_010081: YER056C
subclass of: SO_0000673
so part of: YER056C
location: complement(<266512..>268113)
location: region:266512-268113:-1
so has part: feature:266512-268113:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:266512-268113:-1:exon

YER056C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BRA7
gene: FCY2
locus tag: YER056C
gene synonym: BRA7
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8267570|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0015205 nucleobase transmembrane transporter activity [PMID:9092500]
experiment: EXISTENCE:direct assay:GO:0015212 cytidine transmembrane transporter activity [PMID:10501935]
experiment: EXISTENCE:direct assay:GO:0015856 cytosine transport [PMID:9092500]
experiment: EXISTENCE:direct assay:GO:0015861 cytidine transport [PMID:10501935]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0072530 purine-containing compound transmembrane transport [PMID:9092500]
experiment: EXISTENCE:mutant phenotype:GO:0015212 cytidine transmembrane transporter activity [PMID:10501935]
experiment: EXISTENCE:mutant phenotype:GO:0015861 cytidine transport [PMID:10501935]
note: Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
codon start: 1
product: purine-cytosine permease
translation: MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQQYIVESSEATKLSWFHKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASYALGALGPMVFGLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTARIFSLINVIACVGWGIVNTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYSVIHAYEKWSWVPNFAVFLVIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGWTTYAADYTVYMPKSTNKYKIFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNIDDWDNWEHLPIGIAGTAALIVGAFGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAFIIYNILRPLELKYFGR
SIO_010081: YER056C
subclass of: SO_0000673
so part of: YER056C
location: complement(266512..268113)
location: region:266512-268113:-1
so has part: feature:266512-268113:-1:exon

NP_010976.1
type: Protein
SIO_000068: ncbiprotein

S000000858
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:266512-268113:-1:exon

YER056C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL34A
locus tag: YER056C-A
so part of: sequence
location: complement(<269423..>270185)
location: region:269423-270185:-1
so has part: feature:269423-270185:-1:exon
subclass of: SO_0000010

856784
type: Gene
SIO_000068: ncbigene

position:269423:-1
position: 269423
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:270185:-1
position: 270185
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:269423-270185:-1:exon

YER056C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL34A
locus tag: YER056C-A
product: ribosomal 60S subunit protein L34A
transcript id: NM_001180036.1
SIO_010081: YER056C-A
subclass of: SO_0000673
so part of: YER056C-A
location: complement(join(<269423..269751,270149..>270185))
location: region:269423-270185:-1
so has part: feature:270149-270185:-1:exon
so has part: feature:269423-269751:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270149-270185:-1:exon

position:270149:-1
position: 270149
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:269423-269751:-1:exon

position:269751:-1
position: 269751
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER056C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL34A
locus tag: YER056C-A
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23874617]
experiment: EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:23874617]
note: Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L34A
translation: MAQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATRPKCGDCGSALQGISTLRPRQYATVSKTHKTVSRAYGGSRCANCVKERIIRAFLIEEQKIVKKVVKEQTEAAKKSEKKAKK
SIO_010081: YER056C-A
subclass of: SO_0000673
so part of: YER056C-A
location: complement(join(269423..269751,270149..270185))
location: region:269423-270185:-1
so has part: feature:270149-270185:-1:exon
so has part: feature:269423-269751:-1:exon

NP_010977.2
type: Protein
SIO_000068: ncbiprotein

S000002135
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270149-270185:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:269423-269751:-1:exon

YER057C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HIG1
gene: HMF1
locus tag: YER057C
gene synonym: HIG1
so part of: sequence
location: complement(<270737..>271126)
location: region:270737-271126:-1
so has part: feature:270737-271126:-1:exon
subclass of: SO_0000010

856785
type: Gene
SIO_000068: ncbigene

position:270737:-1
position: 270737
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:271126:-1
position: 271126
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:270737-271126:-1:exon

YER057C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HIG1
gene: HMF1
locus tag: YER057C
gene synonym: HIG1
product: putative isoleucine biosynthesis protein HMF1
transcript id: NM_001178948.3
SIO_010081: YER057C
subclass of: SO_0000673
so part of: YER057C
location: complement(<270737..>271126)
location: region:270737-271126:-1
so has part: feature:270737-271126:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:270737-271126:-1:exon

YER057C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HIG1
gene: HMF1
locus tag: YER057C
gene synonym: HIG1
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11442631]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11442631]
experiment: EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11003673]
note: Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication
codon start: 1
product: putative isoleucine biosynthesis protein HMF1
translation: MVTTLTPVICESAPAAAASYSHAMKVNNLIFLSGQIPVTPDNKLVEGSIADKAEQVIQNIKNVLEASNSSLDRVVKVNIFLADINHFAEFNSVYAKYFNTHKPARSCVAVAALPLGVDMEMEAIAAERD
SIO_010081: YER057C
subclass of: SO_0000673
so part of: YER057C
location: complement(270737..271126)
location: region:270737-271126:-1
so has part: feature:270737-271126:-1:exon

NP_010978.3
type: Protein
SIO_000068: ncbiprotein

S000000859
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:270737-271126:-1:exon

YER058W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PET117
locus tag: YER058W
so part of: sequence
location: <271768..>272091
location: region:271768-272091:1
so has part: feature:271768-272091:1:exon
subclass of: SO_0000010

856786
type: Gene
SIO_000068: ncbigene

position:271768:1
position: 271768
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:272091:1
position: 272091
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:271768-272091:1:exon

YER058W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PET117
locus tag: YER058W
product: Pet117p
transcript id: NM_001178949.1
SIO_010081: YER058W
subclass of: SO_0000673
so part of: YER058W
location: <271768..>272091
location: region:271768-272091:1
so has part: feature:271768-272091:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:271768-272091:1:exon

YER058W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PET117
locus tag: YER058W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:27998984]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:8381337|PMID:27998984]
note: Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)
codon start: 1
product: Pet117p
translation: MSRASKITFAASCLITAATVVGVHYVQEMERETLHQGPIKDAKRVEEKRLRKTNGVASLDPTKERKRYFNMSEHEEQKELRKKYETMQPLSGEVVTKDGEVVKESKK
SIO_010081: YER058W
subclass of: SO_0000673
so part of: YER058W
location: 271768..272091
location: region:271768-272091:1
so has part: feature:271768-272091:1:exon

NP_010979.1
type: Protein
SIO_000068: ncbiprotein

S000000860
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:271768-272091:1:exon

YER059W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PCL6
locus tag: YER059W
so part of: sequence
location: <272624..>273886
location: region:272624-273886:1
so has part: feature:272624-273886:1:exon
subclass of: SO_0000010

856787
type: Gene
SIO_000068: ncbigene

position:272624:1
position: 272624
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:273886:1
position: 273886
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:272624-273886:1:exon

YER059W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PCL6
locus tag: YER059W
product: Pcl6p
transcript id: NM_001178950.1
SIO_010081: YER059W
subclass of: SO_0000673
so part of: YER059W
location: <272624..>273886
location: region:272624-273886:1
so has part: feature:272624-273886:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:272624-273886:1:exon

YER059W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PCL6
locus tag: YER059W
experiment: EXISTENCE:genetic interaction:GO:0005979 regulation of glycogen biosynthetic process [PMID:11602261]
experiment: EXISTENCE:genetic interaction:GO:0005981 regulation of glycogen catabolic process [PMID:11602261]
note: Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication
codon start: 1
product: Pcl6p
translation: MSIKGDSPSSTNASSSPKSTYSIQSDDKANLGSGNVDIRTDNSQQDSNNRRDIVVVTRVASEETLESQSSTSSMGIRPESSFNYEDASNQARVEMNNRVHGSNMNTINKYYPVRFPKNNERQLSDTNNLNEKVQGTHTVQSSTQEDKILDGDTSNSQVTPSLNIAEFPTDKLLKMLTALLTKIIKSNDRTAATNPSLTQEIENGRCLALSDNEKKYLSPVLGFRGKHVPQIGLDQYFQRIQKYCPTTNDVFLSLLVYFDRISKRCNSVTTTPKTNTAKHESPSNESSLDKANRGADKMSACNSNENNENDDSDDENTGVQRDSRAHPQMFVMDSHNIHRLIIAGITVSTKFLSDFFYSNSRYSRVGGISLQELNHLELQFLVLCDFELLISVNELQRYADLLYRFWNNAKAQSQALVTGM
SIO_010081: YER059W
subclass of: SO_0000673
so part of: YER059W
location: 272624..273886
location: region:272624-273886:1
so has part: feature:272624-273886:1:exon

NP_010980.1
type: Protein
SIO_000068: ncbiprotein

S000000861
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:272624-273886:1:exon

YER060W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FCY21
locus tag: YER060W
so part of: sequence
location: <274567..>276153
location: region:274567-276153:1
so has part: feature:274567-276153:1:exon
subclass of: SO_0000010

856788
type: Gene
SIO_000068: ncbigene

position:274567:1
position: 274567
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:276153:1
position: 276153
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:274567-276153:1:exon

YER060W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FCY21
locus tag: YER060W
product: purine-cytosine permease
transcript id: NM_001178951.3
SIO_010081: YER060W
subclass of: SO_0000673
so part of: YER060W
location: <274567..>276153
location: region:274567-276153:1
so has part: feature:274567-276153:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:274567-276153:1:exon

YER060W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FCY21
locus tag: YER060W
experiment: EXISTENCE:mutant phenotype:GO:0015205 nucleobase transmembrane transporter activity [PMID:16845689]
experiment: EXISTENCE:mutant phenotype:GO:0015856 cytosine transport [PMID:16845689]
note: Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function
codon start: 1
product: purine-cytosine permease
translation: MPQTHEMSLNGTQYLKYELKDLESRAHDAKTPSTNEFYDDVESHGTEELVEAKLSFLNRIAAGLSAETKGIEPITEDEKTDDSILNAASMWFSANMVLPAYAIGALGPMVFDLNFGQSVFVIIFFNLLGLVSVAFFSVFGAELGLRQMILSRYLVGNIAARIFSFINFIACIGWGIVNTVASSQVLNMVNPGHQCPLWAGCIVIIGATVIVTFFGYGVIHAYEKWAWVPNFAVFLVIIARLARSKKFVLGEWTSGPTTAGNVLSFGSTVYGFAAGWTTYAADYTVYMPRKTNKYKIFFSLVVGLATPLYFTMILGAAVAMAAIGDPAWKTYYDENSIGGLTFAVLVPNSVHGFGQFCCVLLSLSTIANNVPNMYTIALSVQATWEPLAKVPRVIWTLLGNAAALGIAIPACYYFSTFMNYFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNVDDWDSWERLPIGIAGTAALIVGAFGVALGMCQTYWVGEISRLIGDYGGDIGFELGLSWAFIVYNIARPFELKYFGR
SIO_010081: YER060W
subclass of: SO_0000673
so part of: YER060W
location: 274567..276153
location: region:274567-276153:1
so has part: feature:274567-276153:1:exon

NP_010981.3
type: Protein
SIO_000068: ncbiprotein

S000000862
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:274567-276153:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS513.5; Very weak autonomously replicating sequence
so part of: sequence
location: 276130..276528
location: region:276130-276528:1
so has part: feature:276130-276528:1:region

S000178086
type: SGD
SIO_000068: sgd

position:276130:1
position: 276130
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:276528:1
position: 276528
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276130-276528:1:region

YER060W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FCY22
locus tag: YER060W-A
so part of: sequence
location: <276572..>278164
location: region:276572-278164:1
so has part: feature:276572-278164:1:exon
subclass of: SO_0000010

856789
type: Gene
SIO_000068: ncbigene

position:276572:1
position: 276572
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:278164:1
position: 278164
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:276572-278164:1:exon

YER060W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FCY22
locus tag: YER060W-A
product: purine-cytosine permease
transcript id: NM_001180858.1
SIO_010081: YER060W-A
subclass of: SO_0000673
so part of: YER060W-A
location: <276572..>278164
location: region:276572-278164:1
so has part: feature:276572-278164:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:276572-278164:1:exon

YER060W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FCY22
locus tag: YER060W-A
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0015205 nucleobase transmembrane transporter activity [PMID:16845689]
experiment: EXISTENCE:mutant phenotype:GO:0015856 cytosine transport [PMID:16845689]
note: Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function
codon start: 1
product: purine-cytosine permease
translation: MPEKLAMSMVDIKDAGSELRDLESGALDTKSSAADVYYEGVELHRTNEFIDNKPSFFNRIAAALNAETKGIEPVTEDEKNDDSILNAATIWFSANMVIVAYSVGALGPLVFGLNFGQSVLVIIFFNILGLIPVALFSLFGVELGLRQMILSRYLAGNITARFFSLVNVIACVGWCVLNISVSAQLLNMVNEGSGHNCPIWAGCLIIAGGTVLVTFFGYSVVHAYEKWSWVPNFAAFLVIIAQLSRSGKFKGGEWVGGATTAGGVLSFGSSVFGSAAGWATYAADYTVYMPKTTSKYKIFFSVVAGLAFPLFFTMILGAACGMAALNDPTWKSYYDKNAMGGVIYAILVPNSLNGFGQFCCVLLALSTVANNVPGMYTVALSAQALWAPLAKIPRVVWTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNIDDWDNWEHLPIGIAGTAALIAGAFGVALGMCQTYWVGEISRLIGEYGGDIGFELGGSWAFIIYNIVRPLELKYFGR
SIO_010081: YER060W-A
subclass of: SO_0000673
so part of: YER060W-A
location: 276572..278164
location: region:276572-278164:1
so has part: feature:276572-278164:1:exon

NP_010982.1
type: Protein
SIO_000068: ncbiprotein

S000002958
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:276572-278164:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS513.7; Weak autonomously replicating sequence
so part of: sequence
location: 278076..278357
location: region:278076-278357:1
so has part: feature:278076-278357:1:region

S000178087
type: SGD
SIO_000068: sgd

position:278076:1
position: 278076
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:278357:1
position: 278357
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278076-278357:1:region

YER061C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CEM1
locus tag: YER061C
so part of: sequence
location: complement(<278298..>279626)
location: region:278298-279626:-1
so has part: feature:278298-279626:-1:exon
subclass of: SO_0000010

856790
type: Gene
SIO_000068: ncbigene

position:278298:-1
position: 278298
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:279626:-1
position: 279626
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:278298-279626:-1:exon

YER061C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CEM1
locus tag: YER061C
product: fatty acid synthase CEM1
transcript id: NM_001178952.2
SIO_010081: YER061C
subclass of: SO_0000673
so part of: YER061C
location: complement(<278298..>279626)
location: region:278298-279626:-1
so has part: feature:278298-279626:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:278298-279626:-1:exon

YER061C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CEM1
locus tag: YER061C
EC number: 2.3.1.41
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]
note: Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant
codon start: 1
product: fatty acid synthase CEM1
translation: MSRRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTPITSLPNYNEDYKLREKSIPSTITVGKIPENFQNENSAINKLLFTSQDERRTSSFIKLALRTTYEALHNAGLLNPNDITINTSLCNLDHFGCLIGSGIGSIQDIYQTSLQFHNDNKRINPYFVPKILTNMAAGNVSIKFNLRGLSHSVSTACATGNNSIGDAFNFIRLGMQDICVAGASETSLHPLSLAGFIRAKSITTNGISRPFDTQRSGFVLGEGCGMIVMESLEHAQKRNANIISELVGYGLSSDACHITSPPADGNGAKRAIEMALKMARLEPTDVDYVNAHATSTLLGDKAECLAVASALLPGRSKSKPLYISSNKGAIGHLLGAAGAVESIFTICSLKDDKMPHTLNLDNVLTLENNEADKLHFIRDKPIVGANPKYALCNSFGFGGVNTSLLFKKWEGS
SIO_010081: YER061C
subclass of: SO_0000673
so part of: YER061C
location: complement(278298..279626)
location: region:278298-279626:-1
so has part: feature:278298-279626:-1:exon

NP_010983.2
type: Protein
SIO_000068: ncbiprotein

S000000863
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:278298-279626:-1:exon

YER062C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HOR2
gene: GPP2
locus tag: YER062C
gene synonym: HOR2
so part of: sequence
location: complement(<279930..>280682)
location: region:279930-280682:-1
so has part: feature:279930-280682:-1:exon
subclass of: SO_0000010

856791
type: Gene
SIO_000068: ncbigene

position:279930:-1
position: 279930
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:280682:-1
position: 280682
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:279930-280682:-1:exon

YER062C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HOR2
gene: GPP2
locus tag: YER062C
gene synonym: HOR2
product: glycerol-1-phosphatase HOR2
transcript id: NM_001178953.3
SIO_010081: YER062C
subclass of: SO_0000673
so part of: YER062C
location: complement(<279930..>280682)
location: region:279930-280682:-1
so has part: feature:279930-280682:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:279930-280682:-1:exon

YER062C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HOR2
gene: GPP2
locus tag: YER062C
gene synonym: HOR2
EC number: 3.1.3.21
experiment: EXISTENCE:direct assay:GO:0000121 glycerol-1-phosphatase activity [PMID:8662716]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006970 response to osmotic stress [PMID:8662716]
experiment: EXISTENCE:direct assay:GO:0044262 cellular carbohydrate metabolic process [PMID:8662716]
experiment: EXISTENCE:mutant phenotype:GO:0006114 glycerol biosynthetic process [PMID:11058591]
note: DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication
codon start: 1
product: glycerol-1-phosphatase HOR2
translation: MGLTTKPLSLKVNAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIQVSHGWRTFDAIAKFAPDFANEEYVNKLEAEIPVKYGEKSIEVPGAVKLCNALNALPKEKWAVATSGTRDMAQKWFEHLGIRRPKYFITANDVKQGKPHPEPYLKGRNGLGYPINEQDPSKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFDLDFLKEKGCDIIVKNHESIRVGGYNAETDEVEFIFDDYLYAKDDLLKW
SIO_010081: YER062C
subclass of: SO_0000673
so part of: YER062C
location: complement(279930..280682)
location: region:279930-280682:-1
so has part: feature:279930-280682:-1:exon

NP_010984.3
type: Protein
SIO_000068: ncbiprotein

S000000864
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:279930-280682:-1:exon

YER063W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: THO1
locus tag: YER063W
so part of: sequence
location: <281710..>282366
location: region:281710-282366:1
so has part: feature:281710-282366:1:exon
subclass of: SO_0000010

856792
type: Gene
SIO_000068: ncbigene

position:281710:1
position: 281710
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:282366:1
position: 282366
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:281710-282366:1:exon

YER063W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: THO1
locus tag: YER063W
product: Tho1p
transcript id: NM_001178954.1
SIO_010081: YER063W
subclass of: SO_0000673
so part of: YER063W
location: <281710..>282366
location: region:281710-282366:1
so has part: feature:281710-282366:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:281710-282366:1:exon

YER063W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: THO1
locus tag: YER063W
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16738307]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16738307]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16738307]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:9707445]
experiment: EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:16738307]
experiment: EXISTENCE:mutant phenotype:GO:0022618 ribonucleoprotein complex assembly [PMID:16738307]
note: Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
codon start: 1
product: Tho1p
translation: MADYSSLTVVQLKDLLTKRNLSVGGLKNELVQRLIKDDEESKGESEVSPQEQNQEQGSEPAAIEEPASQNITEKKEVSSEPKETNEPKEENKDVQKPSDGPSATASENEQAAASTAAPALSPEEIKAKALDLLNKKLHRANKFGQDQADIDSLQRQINRVEKFGVDLNSKLAEELGLVSRKNEPESGNNGKFKNRNKNANNRSRVSKNRRGNRSGYRR
SIO_010081: YER063W
subclass of: SO_0000673
so part of: YER063W
location: 281710..282366
location: region:281710-282366:1
so has part: feature:281710-282366:1:exon

NP_010985.1
type: Protein
SIO_000068: ncbiprotein

S000000865
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:281710-282366:1:exon

YER064C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VHR2
locus tag: YER064C
so part of: sequence
location: complement(<282705..>284222)
location: region:282705-284222:-1
so has part: feature:282705-284222:-1:exon
subclass of: SO_0000010

856793
type: Gene
SIO_000068: ncbigene

position:282705:-1
position: 282705
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:284222:-1
position: 284222
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:282705-284222:-1:exon

YER064C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VHR2
locus tag: YER064C
product: Vhr2p
transcript id: NM_001178955.1
SIO_010081: YER064C
subclass of: SO_0000673
so part of: YER064C
location: complement(<282705..>284222)
location: region:282705-284222:-1
so has part: feature:282705-284222:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:282705-284222:-1:exon

YER064C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VHR2
locus tag: YER064C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11342098]
note: Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Vhr2p
translation: MIDDTENSKIHLEGSHKTGKYTGYGTTHKIRAQLNFNDEKKWKKFSSRRLELIDSFGLSQHKASEQDDNIRQIATILRSEFEYPDTFSAEFEKLVTAAVQSVRRNRKRSKKKLLDSKKKIARGKVQKIPLSPPSSSNMGSCSASNASSSDEEASVKEEPAEHALPSLNTITSQKLLPYPNGRTLPPVPTQVRSLLKKNASLLRDPSAPYAHGGDEKLQKFDIEDQPLESEQEYDFIAKSIIVEIVNNAIPLPEQIQRDKFIRPNLTKKKGCQSKVVISNNLRKLILSKIHNSRTCLEMSKDERNLDSFANLETLGKNSLMASISLVVENSFSHLPSSTKQYLTERLSSIEFLTILSQRLFMPATRQLFADLSQEKIQVRVLNLILGSLVKDYGFDASLAPINEIIYHMTLHQYPLVCSNKQSNPMRPHSTSEVLSAHSSTKDASTPGKEEPRVTRSSTSADSTIITLPSIEVPNTYDDDRLKMLSAISLQIENSTFSKPFSTISK
SIO_010081: YER064C
subclass of: SO_0000673
so part of: YER064C
location: complement(282705..284222)
location: region:282705-284222:-1
so has part: feature:282705-284222:-1:exon

NP_010986.1
type: Protein
SIO_000068: ncbiprotein

S000000866
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:282705-284222:-1:exon

YER065C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ICL1
locus tag: YER065C
so part of: sequence
location: complement(<285241..>286914)
location: region:285241-286914:-1
so has part: feature:285241-286914:-1:exon
subclass of: SO_0000010

856794
type: Gene
SIO_000068: ncbigene

position:285241:-1
position: 285241
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:286914:-1
position: 286914
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:285241-286914:-1:exon

YER065C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ICL1
locus tag: YER065C
product: isocitrate lyase 1
transcript id: NM_001178956.3
SIO_010081: YER065C
subclass of: SO_0000673
so part of: YER065C
location: complement(<285241..>286914)
location: region:285241-286914:-1
so has part: feature:285241-286914:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:285241-286914:-1:exon

YER065C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ICL1
locus tag: YER065C
EC number: 4.1.3.1
EC number: 4.1.3.30
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8870676|PMID:9370278]
experiment: EXISTENCE:mutant phenotype:GO:0004451 isocitrate lyase activity [PMID:1551398]
experiment: EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:8878673]
note: Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
codon start: 1
product: isocitrate lyase 1
translation: MPIPVGNTKNDFAALQAKLDADAAEIEKWWSDSRWSKTKRNYSARDIAVRRGTFPPIEYPSSVMARKLFKVLEKHHNEGTVSKTFGALDPVQISQMAKYLDTIYISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEELDEMGAPIDYLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAGRCVIPVQEHVNRLVTIRMCADIMHSDLIVVARTDSEAATLISSTIDTRDHYFIVGATNPNIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHEAVIDEIERSALSNKQELIKKFTSKVGPLTETSHREAKKLAKEILGHEIFFDWELPRVREGLYRYRGGTQCSIMRARAFAPYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLAYNLSPSFNWPKAMSVDEQHTFIQRLGDLGYIWQFITLAGLHTNALAVHNFSRDFAKDGMKAYAQNVQQREMDDGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQFKENGVKK
SIO_010081: YER065C
subclass of: SO_0000673
so part of: YER065C
location: complement(285241..286914)
location: region:285241-286914:-1
so has part: feature:285241-286914:-1:exon

NP_010987.3
type: Protein
SIO_000068: ncbiprotein

S000000867
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:285241-286914:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS514; Autonomously Replicating Sequence
so part of: sequence
location: 287552..287629
location: region:287552-287629:1
so has part: feature:287552-287629:1:region

S000077386
type: SGD
SIO_000068: sgd

position:287552:1
position: 287552
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:287629:1
position: 287629
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287552-287629:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(287745..288062)
location: region:287745-288062:-1
so has part: feature:287745-288062:-1:region

S000006894
type: SGD
SIO_000068: sgd

position:287745:-1
position: 287745
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:288062:-1
position: 288062
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:287745-288062:-1:region

YNCE0015C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SUP19
locus tag: YNCE0015C
so part of: sequence
location: complement(288443..288524)
location: region:288443-288524:-1
so has part: feature:288443-288524:-1:exon
subclass of: SO_0000663

856795
type: Gene
SIO_000068: ncbigene

position:288443:-1
position: 288443
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:288524:-1
position: 288524
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:288443-288524:-1:exon

YNCE0015C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
gene: SUP19
locus tag: YNCE0015C
product: tRNA-Ser
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE analysis; can mutate to suppress ochre nonsense mutations
SIO_010081: YNCE0015C
subclass of: SO_0000673
so part of: YNCE0015C
location: complement(288443..288524)
location: region:288443-288524:-1
so has part: feature:288443-288524:-1:exon

S000006734
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:288443-288524:-1:exon

YER066W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RRT13
locus tag: YER066W
so part of: sequence
location: <290242..>290799
location: region:290242-290799:1
so has part: feature:290242-290799:1:exon
subclass of: SO_0000010

856796
type: Gene
SIO_000068: ncbigene

position:290242:1
position: 290242
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:290799:1
position: 290799
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:290242-290799:1:exon

YER066W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RRT13
locus tag: YER066W
product: Rrt13p
transcript id: NM_001178957.1
SIO_010081: YER066W
subclass of: SO_0000673
so part of: YER066W
location: <290242..>290799
location: region:290242-290799:1
so has part: feature:290242-290799:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:290242-290799:1:exon

YER066W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RRT13
locus tag: YER066W
note: hypothetical protein; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
codon start: 1
product: Rrt13p
translation: MKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIRNNGECSYATNSASPCAKILGAMYTLRGHRALVGLLGLSDKFLVSASVDGSIRCWDANTYFLKHFFDHTQLNTITALHVSDEVLVSGSEGLLNIYDLNSGLLVRSDTLSGADNVWNVSFKDNTLVAAVERDKRNLLEILDFS
SIO_010081: YER066W
subclass of: SO_0000673
so part of: YER066W
location: 290242..290799
location: region:290242-290799:1
so has part: feature:290242-290799:1:exon

NP_010988.1
type: Protein
SIO_000068: ncbiprotein

S000000868
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:290242-290799:1:exon

YER067W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RGI1
locus tag: YER067W
so part of: sequence
location: <292066..>292551
location: region:292066-292551:1
so has part: feature:292066-292551:1:exon
subclass of: SO_0000010

856797
type: Gene
SIO_000068: ncbigene

position:292066:1
position: 292066
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:292551:1
position: 292551
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:292066-292551:1:exon

YER067W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RGI1
locus tag: YER067W
product: Rgi1p
transcript id: NM_001178958.1
SIO_010081: YER067W
subclass of: SO_0000673
so part of: YER067W
location: <292066..>292551
location: region:292066-292551:1
so has part: feature:292066-292551:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:292066-292551:1:exon

YER067W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RGI1
locus tag: YER067W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:20567505]
experiment: EXISTENCE:mutant phenotype:GO:0006112 energy reserve metabolic process [PMID:20567505]
note: Protein involved in energy metabolism under respiratory conditions; abundance is increased upon intracellular iron depletion or in response to DNA replication stress; suppresses pro-apoptotic effect of expressing human BAX in yeast cells; RGI1 has a paralog, RGI2, that arose from the whole genome duplication
codon start: 1
product: Rgi1p
translation: MTKKDKKEVKVQTVTTEDGETVKVFEDLQGFETFIANETEDDDFDHLHCKLNYYPPFVLHESHEDPEKISDAANSHSKKFVRHLHQHIEKHLLKDIKQAVRKPELKFHEKSKEETFDKITWHYGEETEYHGRPFKIDVQVVCTHEDAMVFVDYKTHPVGAN
SIO_010081: YER067W
subclass of: SO_0000673
so part of: YER067W
location: 292066..292551
location: region:292066-292551:1
so has part: feature:292066-292551:1:exon

NP_010990.1
type: Protein
SIO_000068: ncbiprotein

S000000869
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:292066-292551:1:exon

YER068W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NOT4
alternative label: SIG1
gene: MOT2
locus tag: YER068W
gene synonym: NOT4; SIG1
so part of: sequence
location: <293050..>294813
location: region:293050-294813:1
so has part: feature:293050-294813:1:exon
subclass of: SO_0000010

856799
type: Gene
SIO_000068: ncbigene

position:293050:1
position: 293050
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:294813:1
position: 294813
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:293050-294813:1:exon

YER068W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NOT4
alternative label: SIG1
gene: MOT2
locus tag: YER068W
gene synonym: NOT4; SIG1
product: CCR4-NOT core ubiquitin-protein ligase subunit MOT2
transcript id: NM_001178959.3
SIO_010081: YER068W
subclass of: SO_0000673
so part of: YER068W
location: <293050..>294813
location: region:293050-294813:1
so has part: feature:293050-294813:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:293050-294813:1:exon

YER068W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NOT4
alternative label: SIG1
gene: MOT2
locus tag: YER068W
gene synonym: NOT4; SIG1
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:19346402]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16926149]
experiment: EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]
experiment: EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:19346402|PMID:16926149]
experiment: EXISTENCE:genetic interaction:GO:0010498 proteasomal protein catabolic process [PMID:24261871]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:19346402]
experiment: EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]
experiment: EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:11404327]
experiment: EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]
note: Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication
codon start: 1
product: CCR4-NOT core ubiquitin-protein ligase subunit MOT2
translation: MMNPHVQENLQAIHNALSNFDTSFLSEDEEDYCPLCIEPMDITDKNFFPCPCGYQICQFCYNNIRQNPELNGRCPACRRKYDDENVRYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVAPTLKSEKYFGQYGKINKIVVNRKTPHSNNTTSEHYHHHSPGYGVYITFGSKDDAARCIAQVDGTYMDGRLIKAAYGTTKYCSSYLRGLPCPNPNCMFLHEPGEEADSFNKRELHNKQQAQQQSGGTAFTRSGIHNNISTSTAGSNTNLLSENFTGTPSPAAMRAQLHHDSHTNAGTPVLTPAPVPAGSNPWGVTQSATPVTSINLSKNSSSINLPTLNDSLGHHTTPTTENTITSTTTTTNTNATSHSHGSKKKQSLAAEEYKDPYDALGNAVDFLDARLHSLSNYQKRPISIKSNIIDEETYKKYPSLFSWDKIEASKKSDNTLANKLVEILAIKPIDYTASVVQFLQSVNVGVNDNITITDNTKTPTQPIRLQTVSQQIQPPLNVSTPPPGIFGPQHKVPIQQQQMGDTSSRNSSDLLNQLINGRKIIAGN
SIO_010081: YER068W
subclass of: SO_0000673
so part of: YER068W
location: 293050..294813
location: region:293050-294813:1
so has part: feature:293050-294813:1:exon

NP_010991.3
type: Protein
SIO_000068: ncbiprotein

S000000870
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:293050-294813:1:exon

YER069W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ARG56
locus tag: YER069W
so part of: sequence
location: <295410..>298001
location: region:295410-298001:1
so has part: feature:295410-298001:1:exon
subclass of: SO_0000010

856800
type: Gene
SIO_000068: ncbigene

position:295410:1
position: 295410
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:298001:1
position: 298001
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:295410-298001:1:exon

YER069W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ARG56
locus tag: YER069W
product: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
transcript id: NM_001178960.1
SIO_010081: YER069W
subclass of: SO_0000673
so part of: YER069W
location: <295410..>298001
location: region:295410-298001:1
so has part: feature:295410-298001:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:295410-298001:1:exon

YER069W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ARG56
locus tag: YER069W
EC number: 1.2.1.38
EC number: 2.7.2.8
experiment: EXISTENCE:direct assay:GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity [PMID:1851947]
experiment: EXISTENCE:direct assay:GO:0003991 acetylglutamate kinase activity [PMID:1851947]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1851947]
experiment: EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:15486299]
note: Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
codon start: 1
product: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
translation: MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV
SIO_010081: YER069W
subclass of: SO_0000673
so part of: YER069W
location: 295410..298001
location: region:295410-298001:1
so has part: feature:295410-298001:1:exon

NP_010992.1
type: Protein
SIO_000068: ncbiprotein

S000000871
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:295410-298001:1:exon

YER070W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CRT7
alternative label: RIR1
alternative label: SDS12
gene: RNR1
locus tag: YER070W
gene synonym: CRT7; RIR1; SDS12
so part of: sequence
location: <298950..>301616
location: region:298950-301616:1
so has part: feature:298950-301616:1:exon
subclass of: SO_0000010

856801
type: Gene
SIO_000068: ncbigene

position:298950:1
position: 298950
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:301616:1
position: 301616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:298950-301616:1:exon

YER070W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CRT7
alternative label: RIR1
alternative label: SDS12
gene: RNR1
locus tag: YER070W
gene synonym: CRT7; RIR1; SDS12
product: ribonucleotide-diphosphate reductase subunit RNR1
transcript id: NM_001178961.1
SIO_010081: YER070W
subclass of: SO_0000673
so part of: YER070W
location: <298950..>301616
location: region:298950-301616:1
so has part: feature:298950-301616:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:298950-301616:1:exon

YER070W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CRT7
alternative label: RIR1
alternative label: SDS12
gene: RNR1
locus tag: YER070W
gene synonym: CRT7; RIR1; SDS12
EC number: 1.17.4.1
experiment: EXISTENCE:direct assay:GO:0000166 nucleotide binding [PMID:16537479]
experiment: EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:10535923|PMID:10716984|PMID:11893751]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12732713|PMID:9315670|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:10716984]
experiment: EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:10535923|PMID:5459124]
experiment: EXISTENCE:mutant phenotype:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:8552025]
note: Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication
codon start: 1
product: ribonucleotide-diphosphate reductase subunit RNR1
translation: MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEASREASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSKVIACAIDNPEACEMCSG
SIO_010081: YER070W
subclass of: SO_0000673
so part of: YER070W
location: 298950..301616
location: region:298950-301616:1
so has part: feature:298950-301616:1:exon

NP_010993.1
type: Protein
SIO_000068: ncbiprotein

S000000872
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:298950-301616:1:exon

YER071C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TDA2
locus tag: YER071C
so part of: sequence
location: complement(<301947..>302327)
location: region:301947-302327:-1
so has part: feature:301947-302327:-1:exon
subclass of: SO_0000010

856802
type: Gene
SIO_000068: ncbigene

position:301947:-1
position: 301947
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:302327:-1
position: 302327
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:301947-302327:-1:exon

YER071C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TDA2
locus tag: YER071C
product: Tda2p
transcript id: NM_001178962.3
SIO_010081: YER071C
subclass of: SO_0000673
so part of: YER071C
location: complement(<301947..>302327)
location: region:301947-302327:-1
so has part: feature:301947-302327:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:301947-302327:-1:exon

YER071C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TDA2
locus tag: YER071C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:28706108|PMID:29467252]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]
experiment: EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:29467252]
experiment: EXISTENCE:physical interaction:GO:0030837 negative regulation of actin filament polymerization [PMID:29467252]
experiment: EXISTENCE:physical interaction:GO:0110131 Aim21-Tda2 complex [PMID:28706108|PMID:29467252]
note: Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele
codon start: 1
product: Tda2p
translation: MSMQIEIKDGRSDNSPLPERKLVTLIQESYDSLKDDNEINLSTESTSNLLIKLVLEKLEKHSSLYKYIASVTTLNIEGLNEENANFSLKNDIGASWESKKDGIFNYKLEDKNNNECYLITILWLHK
SIO_010081: YER071C
subclass of: SO_0000673
so part of: YER071C
location: complement(301947..302327)
location: region:301947-302327:-1
so has part: feature:301947-302327:-1:exon

NP_010994.3
type: Protein
SIO_000068: ncbiprotein

S000000873
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:301947-302327:-1:exon

YER072W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NRF1
alternative label: PHM4
gene: VTC1
locus tag: YER072W
gene synonym: NRF1; PHM4
so part of: sequence
location: <302806..>303195
location: region:302806-303195:1
so has part: feature:302806-303195:1:exon
subclass of: SO_0000010

856803
type: Gene
SIO_000068: ncbigene

position:302806:1
position: 302806
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:303195:1
position: 303195
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:302806-303195:1:exon

YER072W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NRF1
alternative label: PHM4
gene: VTC1
locus tag: YER072W
gene synonym: NRF1; PHM4
product: Vtc1p
transcript id: NM_001178963.1
SIO_010081: YER072W
subclass of: SO_0000673
so part of: YER072W
location: <302806..>303195
location: region:302806-303195:1
so has part: feature:302806-303195:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:302806-303195:1:exon

YER072W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NRF1
alternative label: PHM4
gene: VTC1
locus tag: YER072W
gene synonym: NRF1; PHM4
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]
experiment: EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:12584253]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]
experiment: EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]
experiment: EXISTENCE:direct assay:GO:0016237 lysosomal microautophagy [PMID:17079729]
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:27831485]
experiment: EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525|PMID:19390046]
experiment: EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27252384]
experiment: EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]
experiment: EXISTENCE:mutant phenotype:GO:0016237 lysosomal microautophagy [PMID:17079729]
experiment: EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:11823419|PMID:27252384]
experiment: EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]
note: Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress
codon start: 1
product: Vtc1p
translation: MSSAPLLQRTPGKKIALPTRVEPKVFFANERTFLSWLNFTVMLGGLGVGLLNFGDKIGRVSAGLFTFVAMGTMIYALVTYHWRAAAIRRRGSGPYDDRLGPTLLCFFLLVAVIINFILRLKYNDANTKL
SIO_010081: YER072W
subclass of: SO_0000673
so part of: YER072W
location: 302806..303195
location: region:302806-303195:1
so has part: feature:302806-303195:1:exon

NP_010995.1
type: Protein
SIO_000068: ncbiprotein

S000000874
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:302806-303195:1:exon

YER073W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ALD5
locus tag: YER073W
so part of: sequence
location: <304030..>305592
location: region:304030-305592:1
so has part: feature:304030-305592:1:exon
subclass of: SO_0000010

856804
type: Gene
SIO_000068: ncbigene

position:304030:1
position: 304030
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:305592:1
position: 305592
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:304030-305592:1:exon

YER073W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ALD5
locus tag: YER073W
product: aldehyde dehydrogenase (NAD(P)(+)) ALD5
transcript id: NM_001178964.2
SIO_010081: YER073W
subclass of: SO_0000673
so part of: YER073W
location: <304030..>305592
location: region:304030-305592:1
so has part: feature:304030-305592:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:304030-305592:1:exon

YER073W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ALD5
locus tag: YER073W
EC number: 1.2.1.4
experiment: EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:9473035]
experiment: EXISTENCE:direct assay:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9473035]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10585550|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:15256563]
note: Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
codon start: 1
product: aldehyde dehydrogenase (NAD(P)(+)) ALD5
translation: MLSRTRAAAPNSRIFTRSLLRLYSQAPLRVPITLPNGFTYEQPTGLFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPEVRAKALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGNVIDTGKNHFTYSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEAGIPAGVVNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAADTVKKVTLELGGKSPNIVFADADLDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESLKVGDPFDEEVFQGAQTSDKQLHKILDYVDVAKSEGARLVTGGARHGSKGYFVKPTVFADVKEDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDSQYGLAAGIHTNDINKAVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREMGEAALSNYTQTKSVRIAIDKPIR
SIO_010081: YER073W
subclass of: SO_0000673
so part of: YER073W
location: 304030..305592
location: region:304030-305592:1
so has part: feature:304030-305592:1:exon

NP_010996.2
type: Protein
SIO_000068: ncbiprotein

S000000875
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:304030-305592:1:exon

YER074W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RPS24EA
gene: RPS24A
locus tag: YER074W
gene synonym: RPS24EA
so part of: sequence
location: <306323..>307196
location: region:306323-307196:1
so has part: feature:306323-307196:1:exon
subclass of: SO_0000010

856805
type: Gene
SIO_000068: ncbigene

position:306323:1
position: 306323
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:307196:1
position: 307196
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:306323-307196:1:exon

YER074W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RPS24EA
gene: RPS24A
locus tag: YER074W
gene synonym: RPS24EA
product: ribosomal 40S subunit protein S24A
transcript id: NM_001178965.3
SIO_010081: YER074W
subclass of: SO_0000673
so part of: YER074W
location: join(<306323..306325,306792..>307196)
location: region:306323-307196:1
so has part: feature:306323-306325:1:exon
so has part: feature:306792-307196:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:306323-306325:1:exon

position:306325:1
position: 306325
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:306792-307196:1:exon

position:306792:1
position: 306792
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YER074W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RPS24EA
gene: RPS24A
locus tag: YER074W
gene synonym: RPS24EA
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S24A
translation: MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGKRLAKKVARRNAD
SIO_010081: YER074W
subclass of: SO_0000673
so part of: YER074W
location: join(306323..306325,306792..307196)
location: region:306323-307196:1
so has part: feature:306323-306325:1:exon
so has part: feature:306792-307196:1:exon

NP_010997.3
type: Protein
SIO_000068: ncbiprotein

S000000876
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:306323-306325:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:306792-307196:1:exon

YER074W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: YOS1
locus tag: YER074W-A
so part of: sequence
location: <307653..>308123
location: region:307653-308123:1
so has part: feature:307653-308123:1:exon
subclass of: SO_0000010

856806
type: Gene
SIO_000068: ncbigene

position:307653:1
position: 307653
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:308123:1
position: 308123
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:307653-308123:1:exon

YER074W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: YOS1
locus tag: YER074W-A
product: Yos1p
transcript id: NM_001184512.1
SIO_010081: YER074W-A
subclass of: SO_0000673
so part of: YER074W-A
location: join(<307653..307746,307849..307956,308068..>308123)
location: region:307653-308123:1
so has part: feature:307653-307746:1:exon
so has part: feature:307849-307956:1:exon
so has part: feature:308068-308123:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:307653-307746:1:exon

position:307746:1
position: 307746
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:307849-307956:1:exon

position:307849:1
position: 307849
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:307956:1
position: 307956
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 3
SIO_000628: feature:308068-308123:1:exon

position:308068:1
position: 308068
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YER074W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: YOS1
locus tag: YER074W-A
experiment: EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15659647]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]
experiment: EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15659647]
experiment: EXISTENCE:physical interaction:GO:0000139 Golgi membrane [PMID:15659647]
experiment: EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]
experiment: EXISTENCE:physical interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]
note: Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p
codon start: 1
product: Yos1p
translation: MVLFGLGRLFYVILLLINAVAVLSEERFLRRIGLGRSNDETPVFGQDQNTTKSKVVQLIGAVQTLLRIPLIGINILVIVYELLLG
SIO_010081: YER074W-A
subclass of: SO_0000673
so part of: YER074W-A
location: join(307653..307746,307849..307956,308068..308123)
location: region:307653-308123:1
so has part: feature:307653-307746:1:exon
so has part: feature:307849-307956:1:exon
so has part: feature:308068-308123:1:exon

NP_219496.2
type: Protein
SIO_000068: ncbiprotein

S000007651
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:307653-307746:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:307849-307956:1:exon

urn:…
SIO_000300: 3
SIO_000628: feature:308068-308123:1:exon

YER075C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTP3
locus tag: YER075C
so part of: sequence
location: complement(<308413..>311199)
location: region:308413-311199:-1
so has part: feature:308413-311199:-1:exon
subclass of: SO_0000010

856807
type: Gene
SIO_000068: ncbigene

position:308413:-1
position: 308413
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:311199:-1
position: 311199
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:308413-311199:-1:exon

YER075C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTP3
locus tag: YER075C
product: tyrosine protein phosphatase PTP3
transcript id: NM_001178966.2
SIO_010081: YER075C
subclass of: SO_0000673
so part of: YER075C
location: complement(<308413..>311199)
location: region:308413-311199:-1
so has part: feature:308413-311199:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:308413-311199:-1:exon

YER075C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTP3
locus tag: YER075C
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:9224718]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17952059]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17952059|PMID:10523653]
experiment: EXISTENCE:direct assay:GO:0035335 peptidyl-tyrosine dephosphorylation [PMID:9224718]
experiment: EXISTENCE:genetic interaction:GO:0035335 peptidyl-tyrosine dephosphorylation [PMID:9224718|PMID:10523653]
experiment: EXISTENCE:genetic interaction:GO:0043937 regulation of sporulation [PMID:10679022]
experiment: EXISTENCE:genetic interaction:GO:0071507 pheromone response MAPK cascade [PMID:9224718]
experiment: EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10523653]
experiment: EXISTENCE:genetic interaction:GO:1903138 negative regulation of cell wall integrity MAPK cascade [PMID:10523653]
experiment: EXISTENCE:mutant phenotype:GO:0035335 peptidyl-tyrosine dephosphorylation [PMID:9224718]
experiment: EXISTENCE:mutant phenotype:GO:0051220 cytoplasmic sequestering of protein [PMID:10817757]
note: Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm
codon start: 1
product: tyrosine protein phosphatase PTP3
translation: MKDSVDCPSILPTDRTSVLSETSTLVGSSSHVYSRHAPMNSYHNSMNSNIYHSPKASSPLVSYKTSSPVLLKRATAPVLPSFKPKEQRYNKPQGCSLITAVELGKIIETLPDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQSVLKSKLAIDNLRIIIYDSTANQTESSVSLPCYGIASKLIEFDTNVKKTVSILMCGFPQFKILFPDHINTNTFNSDCISSAEPKSPKTNLMNSLHNTAPHMTATTPLSSPQMNLKLKVPDDSRSDHSNFSSSPSPRNVLSDSPMSSSSPISALFKFQLPAPQTNINQMFKFSQNEEIMGLETYLSAVNIKEEHERWYNNDSAKKSLQNFQFPKNQNSLEKDTNKDKLGFQIRYENLSKNYEKEVIDSVIPEWFQHLMSIPKIELVSQFQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSSTIMPPKFPDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKHSHSTSDGGILDNYINANYLSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLDDITERTDGDGSNKDNISLSALIEQIEKLEILQTFVDDKLKELPQ
SIO_010081: YER075C
subclass of: SO_0000673
so part of: YER075C
location: complement(308413..311199)
location: region:308413-311199:-1
so has part: feature:308413-311199:-1:exon

NP_010998.2
type: Protein
SIO_000068: ncbiprotein

S000000877
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:308413-311199:-1:exon

YNCE0016C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0016C
so part of: sequence
location: complement(312023..312095)
location: region:312023-312095:-1
so has part: feature:312023-312095:-1:exon
subclass of: SO_0000663

856808
type: Gene
SIO_000068: ncbigene

position:312023:-1
position: 312023
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:312095:-1
position: 312095
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312023-312095:-1:exon

YNCE0016C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0016C
product: tRNA-Ala
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE analysis; one of 5 nuclear tRNA genes containing the tDNA-anticodon TGC (mature tRNA may be UGC or may contain modified bases), decodes GCA and probably GCG codons into alanine, one of 16 nuclear tRNAs for alanine
SIO_010081: YNCE0016C
subclass of: SO_0000673
so part of: YNCE0016C
location: complement(312023..312095)
location: region:312023-312095:-1
so has part: feature:312023-312095:-1:exon

S000006522
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:312023-312095:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 312274..312445
location: region:312274-312445:1
so has part: feature:312274-312445:1:region

S000006914
type: SGD
SIO_000068: sgd

position:312274:1
position: 312274
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:312445:1
position: 312445
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312274-312445:1:region

YER076C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER076C
so part of: sequence
location: complement(<312590..>313498)
location: region:312590-313498:-1
so has part: feature:312590-313498:-1:exon
subclass of: SO_0000010

856809
type: Gene
SIO_000068: ncbigene

position:312590:-1
position: 312590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:313498:-1
position: 313498
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:312590-313498:-1:exon

YER076C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER076C
product: uncharacterized protein
transcript id: NM_001178967.3
SIO_010081: YER076C
subclass of: SO_0000673
so part of: YER076C
location: complement(<312590..>313498)
location: region:312590-313498:-1
so has part: feature:312590-313498:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:312590-313498:-1:exon

YER076C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER076C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
codon start: 1
product: uncharacterized protein
translation: MTSGYYTVSFFYAILLLCACTRAEIYLTGGESQGLPSGFWQMDDDLAIAPVSMVEFYQTIGLTANGTVPESFNKRDATEYPNIISNITTQAANFTQHSLVEQLQNDVTAISISNAINVAVDGSVETPADLQYNRNQETGESTLCRAKFYGVEVRTWSRLYNRAVSSTTLTTNLNSYIAQWVAWAVHGSGDKKFCGSQEFTNIFFDGQEGWSLFVKTWSTNSSCDITASEGNLTCAVRVSVSSMHNHGKTAFCVTYSHGDSWRAELRVVANDAWSHYYPWSIDCPEVDKNNMAINDCFDQAQG
SIO_010081: YER076C
subclass of: SO_0000673
so part of: YER076C
location: complement(312590..313498)
location: region:312590-313498:-1
so has part: feature:312590-313498:-1:exon

NP_010999.3
type: Protein
SIO_000068: ncbiprotein

S000000878
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:312590-313498:-1:exon

YER077C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MRX1
locus tag: YER077C
so part of: sequence
location: complement(<314534..>316600)
location: region:314534-316600:-1
so has part: feature:314534-316600:-1:exon
subclass of: SO_0000010

856810
type: Gene
SIO_000068: ncbigene

position:314534:-1
position: 314534
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:316600:-1
position: 316600
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:314534-316600:-1:exon

YER077C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MRX1
locus tag: YER077C
product: Mrx1p
transcript id: NM_001178968.1
SIO_010081: YER077C
subclass of: SO_0000673
so part of: YER077C
location: complement(<314534..>316600)
location: region:314534-316600:-1
so has part: feature:314534-316600:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:314534-316600:-1:exon

YER077C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MRX1
locus tag: YER077C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]
note: Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
codon start: 1
product: Mrx1p
translation: MGLKITKGQLRTKDLNQSSSKSSQSSRIGVDTCIFTRMLPRINTAINLTEHLLRRSFHSLTNLQKTQVKERLHELERHGFILNKTSKQLERINSKKRRQLKKLQKTAYPKDQAFHILRKFHKINNEALADTKLGPTSQSDLKFLSLTKDKRLFYTILGVNGEQLRDSKLIANDVQKFLKRGQLEKAVFLARLAKKKGVVGMNLIMKYYIEVVQSQQSAVDIFNWRKKWGVPIDQHSITILFNGLSKQENLVSKKYGELVLKTIDSLCDKNELTEIEYNTALAALINCTDETLVFKLLNKKCPGLKKDSITYTLMIRSCTRIADEKRFMVVLNDLMNKIPDYCVDSKLLFEYCEVICSQKSPKIEKQGMGLWALCEYFQFDKTIFKKYLTQSDFPTLVPLSHWNINKPFPLNKHVVGLFMNYCLKNKEYDLAMEIFKTLEAQNNQMLDQSIYHKYMETVITTRPITCGDECLDIYERVASSAQISITRRTLILVYNAFQRQSLKAVINKDASNAEATLHKIRGFIDSVEATYSSKLNGKVYRFNSWKFLFPIVKNLNMNDKVSTVELKSILDEYLKSLLNGEFGKEFKASIEDKRFVTLEGIRLVKVLTERIKLPSLDSEEIASLKGTERKKFLARRHLLRLKQILLEDLADIEGNSRRKGDSENTSTSEERIMEDLAELILETSYDKF
SIO_010081: YER077C
subclass of: SO_0000673
so part of: YER077C
location: complement(314534..316600)
location: region:314534-316600:-1
so has part: feature:314534-316600:-1:exon

NP_011000.1
type: Protein
SIO_000068: ncbiprotein

S000000879
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:314534-316600:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS515; Autonomously Replicating Sequence
so part of: sequence
location: 316600..316807
location: region:316600-316807:1
so has part: feature:316600-316807:1:region

S000077387
type: SGD
SIO_000068: sgd

position:316600:1
position: 316600
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:316807:1
position: 316807
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316600-316807:1:region

YER078C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ICP55
locus tag: YER078C
so part of: sequence
location: complement(<316807..>318342)
location: region:316807-318342:-1
so has part: feature:316807-318342:-1:exon
subclass of: SO_0000010

856811
type: Gene
SIO_000068: ncbigene

position:316807:-1
position: 316807
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:318342:-1
position: 318342
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:316807-318342:-1:exon

YER078C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ICP55
locus tag: YER078C
product: aminopeptidase
transcript id: NM_001178969.1
SIO_010081: YER078C
subclass of: SO_0000673
so part of: YER078C
location: complement(<316807..>318342)
location: region:316807-318342:-1
so has part: feature:316807-318342:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:316807-318342:-1:exon

YER078C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ICP55
locus tag: YER078C
EC number: 3.4.11.26
experiment: EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:19720832]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19720832]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19720832|PMID:14562095|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0016485 protein processing [PMID:19837041]
experiment: EXISTENCE:mutant phenotype:GO:0004177 aminopeptidase activity [PMID:19720832|PMID:19837041]
experiment: EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:19720832|PMID:19837041]
experiment: EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:19837041]
note: Mitochondrial aminopeptidase; cleaves N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of aminopeptidase P family; exists in rapid equilibrium between monomer and dimer, with dimer being active species; ortholog of human gene XPNPEP3, which is mutated in rare hereditary kidney disease similar to nephronophthisis
codon start: 1
product: aminopeptidase
translation: MLHRINPVRFSMQSCQRYFSKLVSPLEQHKSNTFTNRVRIPIEAGQPLHETRPFLIKSGELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQFASGAVFYPFQQENDLFYLSGWNEPNSVMILEKPTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQEIFNADESASINDLSKYLPKIINRNDFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRSLNSIANKTIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSFLHYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIPNEESFPSYFRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVMQNGLSTKFEEDQVAPL
SIO_010081: YER078C
subclass of: SO_0000673
so part of: YER078C
location: complement(316807..318342)
location: region:316807-318342:-1
so has part: feature:316807-318342:-1:exon

NP_011001.1
type: Protein
SIO_000068: ncbiprotein

S000000880
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:316807-318342:-1:exon

YER078W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER078W-A
so part of: sequence
location: <318646..>318810
location: region:318646-318810:1
so has part: feature:318646-318810:1:exon
subclass of: SO_0000010

1466536
type: Gene
SIO_000068: ncbigene

position:318646:1
position: 318646
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:318810:1
position: 318810
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318646-318810:1:exon

YER078W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER078W-A
product: uncharacterized protein
transcript id: NM_001184548.3
SIO_010081: YER078W-A
subclass of: SO_0000673
so part of: YER078W-A
location: <318646..>318810
location: region:318646-318810:1
so has part: feature:318646-318810:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:318646-318810:1:exon

YER078W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER078W-A
note: hypothetical protein; identified by fungal homology and RT-PCR
codon start: 1
product: uncharacterized protein
translation: MVRLSYLRLILPPCRLSELSSLAILYQPVIPILISTITFQHFFKCVHTPCNVYI
SIO_010081: YER078W-A
subclass of: SO_0000673
so part of: YER078W-A
location: 318646..318810
location: region:318646-318810:1
so has part: feature:318646-318810:1:exon

NP_878068.3
type: Protein
SIO_000068: ncbiprotein

S000028546
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:318646-318810:1:exon

YER079W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER079W
so part of: sequence
location: <318920..>319552
location: region:318920-319552:1
so has part: feature:318920-319552:1:exon
subclass of: SO_0000010

856812
type: Gene
SIO_000068: ncbigene

position:318920:1
position: 318920
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:319552:1
position: 319552
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:318920-319552:1:exon

YER079W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER079W
product: uncharacterized protein
transcript id: NM_001178970.1
SIO_010081: YER079W
subclass of: SO_0000673
so part of: YER079W
location: <318920..>319552
location: region:318920-319552:1
so has part: feature:318920-319552:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:318920-319552:1:exon

YER079W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER079W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
codon start: 1
product: uncharacterized protein
translation: MPDSSHSISSKDVASAISLYDQSIYTNNRSTNLDLDQRSMSPSNIASGEDRITRTNSGCSITSGASMIATKDGIQGINVKRDGIPKYSLNLLNSMVRKQYDHNNGTKSPTPKTSNMVDPKNKKKNKKKKNDKDDKYKVSHDQTEKFYKLNTTSNSNLTSDSTTSLSDQFYFQKSNADSAPLDNANYPLSDHSPSLNSMDNTTKHSSNVHT
SIO_010081: YER079W
subclass of: SO_0000673
so part of: YER079W
location: 318920..319552
location: region:318920-319552:1
so has part: feature:318920-319552:1:exon

NP_011002.1
type: Protein
SIO_000068: ncbiprotein

S000000881
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:318920-319552:1:exon

YER080W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: FMP29
gene: AIM9
locus tag: YER080W
gene synonym: FMP29
so part of: sequence
location: <319963..>321846
location: region:319963-321846:1
so has part: feature:319963-321846:1:exon
subclass of: SO_0000010

856813
type: Gene
SIO_000068: ncbigene

position:319963:1
position: 319963
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:321846:1
position: 321846
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:319963-321846:1:exon

YER080W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: FMP29
gene: AIM9
locus tag: YER080W
gene synonym: FMP29
product: Aim9p
transcript id: NM_001178971.1
SIO_010081: YER080W
subclass of: SO_0000673
so part of: YER080W
location: <319963..>321846
location: region:319963-321846:1
so has part: feature:319963-321846:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:319963-321846:1:exon

YER080W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: FMP29
gene: AIM9
locus tag: YER080W
gene synonym: FMP29
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
codon start: 1
product: Aim9p
translation: MIRYTVAGHSRRCVVGASKRVGAIKCITVAATKRFISNKPNEVFTKLTNDNDPKRDAFFKYTWGSWLKNDKQEKEKRFTKFSIEGLNRILNDIYIQSNEMAKAPDGKILPPVFNKNLTVSLVNNVVPKNIGKINPNEKVQVTTLSSIHEGKHHRIYKVDTNLNKAFILRIPYPLENENTLSYRIRSEVATMDFADLKLGIKVPKIFCYGVNSLNPVRQPFVLQEFIEGELLMKDWDPLIEDGSSNQKKYDNVIKQVSDFQSKLVSLKLNAFGSIYFNNDLKDGNEKEFVKEDIYDGETNPDLQNRWKIGPSVERCLWRHKSHLDFHKQMKPFLGPWPKKSPMDIIKNTGLLEAENAKTRIAMKEAGSSAELMYPRTLKEQITTYENLAKIAPDLFNVKTKAIPNMQELLSPRLFHPDLDPMNIIVNKEAQEAYLLDFEGACTKPFILQNSPQFIAYDGPKIYDLKEDITDFDKLSEAEKVQYQFMYKRTRNQHQWEKKLNDNNPKLITAVAPPVKLLRSPYIAAVERKTEEEYLLIDESLLQLKEVWDIFAQNELVNQKKFPLNYSKEDIERHVEDLQKLHEKLISTPFAATQGWIPQDMFDQLLNSGSIVKQENGDYTVKQPEATK
SIO_010081: YER080W
subclass of: SO_0000673
so part of: YER080W
location: 319963..321846
location: region:319963-321846:1
so has part: feature:319963-321846:1:exon

NP_011003.1
type: Protein
SIO_000068: ncbiprotein

S000000882
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:319963-321846:1:exon

YNCE0017W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SRG1
locus tag: YNCE0017W
so part of: sequence
location: 322212..322762
location: region:322212-322762:1
so has part: feature:322212-322762:1:exon
subclass of: SO_0000011

9164885
type: Gene
SIO_000068: ncbigene

position:322212:1
position: 322212
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:322762:1
position: 322762
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:322212-322762:1:exon

YNCE0017W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: other
gene: SRG1
locus tag: YNCE0017W
product: SRG1
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:15175754]
experiment: EXISTENCE:expression pattern:GO:0045892 negative regulation of DNA-templated transcription [PMID:15175754]
experiment: EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:15175754]
note: Non-protein-coding RNA that regulates the transcription of SER3; expression of SRG1 RNA represses expression of its neighboring gene SER3 via a transcription-interference mechanism
transcript id: NR_132168.1
SIO_010081: YNCE0017W
subclass of: SO_0000673
so part of: YNCE0017W
location: 322212..322762
location: region:322212-322762:1
so has part: feature:322212-322762:1:exon

S000029010
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:322212-322762:1:exon

YER081W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SER3
locus tag: YER081W
so part of: sequence
location: <322686..>324095
location: region:322686-324095:1
so has part: feature:322686-324095:1:exon
subclass of: SO_0000010

856814
type: Gene
SIO_000068: ncbigene

position:322686:1
position: 322686
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:324095:1
position: 324095
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:322686-324095:1:exon

YER081W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SER3
locus tag: YER081W
product: phosphoglycerate dehydrogenase SER3
transcript id: NM_001178972.3
SIO_010081: YER081W
subclass of: SO_0000673
so part of: YER081W
location: <322686..>324095
location: region:322686-324095:1
so has part: feature:322686-324095:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:322686-324095:1:exon

YER081W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SER3
locus tag: YER081W
EC number: 1.1.1.95
EC number: 1.1.1.399
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]
experiment: EXISTENCE:genetic interaction:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]
experiment: EXISTENCE:mutant phenotype:GO:0004617 phosphoglycerate dehydrogenase activity [PMID:12525494]
experiment: EXISTENCE:mutant phenotype:GO:0009070 serine family amino acid biosynthetic process [PMID:12525494]
experiment: EXISTENCE:mutant phenotype:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]
note: 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER3 has a paralog, SER33, that arose from the whole genome duplication
codon start: 1
product: phosphoglycerate dehydrogenase SER3
translation: MTSIDINNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAVKHPKILKPFSTGDMKILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVLQHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDILSNHNIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY
SIO_010081: YER081W
subclass of: SO_0000673
so part of: YER081W
location: 322686..324095
location: region:322686-324095:1
so has part: feature:322686-324095:1:exon

NP_011004.3
type: Protein
SIO_000068: ncbiprotein

S000000883
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:322686-324095:1:exon

YER082C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KRE31
gene: UTP7
locus tag: YER082C
gene synonym: KRE31
so part of: sequence
location: complement(<324272..>325936)
location: region:324272-325936:-1
so has part: feature:324272-325936:-1:exon
subclass of: SO_0000010

856815
type: Gene
SIO_000068: ncbigene

position:324272:-1
position: 324272
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:325936:-1
position: 325936
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:324272-325936:-1:exon

YER082C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KRE31
gene: UTP7
locus tag: YER082C
gene synonym: KRE31
product: Utp7p
transcript id: NM_001178973.1
SIO_010081: YER082C
subclass of: SO_0000673
so part of: YER082C
location: complement(<324272..>325936)
location: region:324272-325936:-1
so has part: feature:324272-325936:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:324272-325936:-1:exon

YER082C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KRE31
gene: UTP7
locus tag: YER082C
gene synonym: KRE31
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309|PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:15167894]
experiment: EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292|PMID:15590835]
experiment: EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]
experiment: EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292|PMID:15590835]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292|PMID:15590835]
note: Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
codon start: 1
product: Utp7p
translation: MGHKKNGHRRQIKERENQNKFERSTYTNNAKNNHTQTKDKKLRAGLKKIDEQYKKAVSSAAATDYLLPESNGYLEPENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNEQYFAVAQKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRGPHVTLWKDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVPFEDLLGVGHQTGITNLIVPGAGEANYDALELNPFETKKQRQEQEVRTLLNKLPADTITLDPNSIGSVDKRSSTIRLNAKDLAQTTMDANNKAKTNSDIPDVKPDVKGKNSGLRSFLRKKTQNVIDERKLRVQKQLDKEKNIRKRNHQIKQGLISEDHKDVIEEALSRFG
SIO_010081: YER082C
subclass of: SO_0000673
so part of: YER082C
location: complement(324272..325936)
location: region:324272-325936:-1
so has part: feature:324272-325936:-1:exon

NP_011005.1
type: Protein
SIO_000068: ncbiprotein

S000000884
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:324272-325936:-1:exon

YER083C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HUR2
alternative label: RMD7
gene: GET2
locus tag: YER083C
gene synonym: HUR2; RMD7
so part of: sequence
location: complement(<326174..>327031)
location: region:326174-327031:-1
so has part: feature:326174-327031:-1:exon
subclass of: SO_0000010

856817
type: Gene
SIO_000068: ncbigene

position:326174:-1
position: 326174
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:327031:-1
position: 327031
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:326174-327031:-1:exon

YER083C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HUR2
alternative label: RMD7
gene: GET2
locus tag: YER083C
gene synonym: HUR2; RMD7
product: GET complex subunit GET2
transcript id: NM_001178974.1
SIO_010081: YER083C
subclass of: SO_0000673
so part of: YER083C
location: complement(<326174..>327031)
location: region:326174-327031:-1
so has part: feature:326174-327031:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:326174-327031:-1:exon

YER083C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HUR2
alternative label: RMD7
gene: GET2
locus tag: YER083C
gene synonym: HUR2; RMD7
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
experiment: EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:18724936]
experiment: EXISTENCE:genetic interaction:GO:0043529 GET complex [PMID:16269340]
experiment: EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:18724936]
experiment: EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]
note: Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
codon start: 1
product: GET complex subunit GET2
translation: MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAESPLDAPSAAKTTPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPDLLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLLPYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHKSKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGLLTYL
SIO_010081: YER083C
subclass of: SO_0000673
so part of: YER083C
location: complement(326174..327031)
location: region:326174-327031:-1
so has part: feature:326174-327031:-1:exon

NP_011006.2
type: Protein
SIO_000068: ncbiprotein

S000000885
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:326174-327031:-1:exon

YER084W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER084W
so part of: sequence
location: <327065..>327451
location: region:327065-327451:1
so has part: feature:327065-327451:1:exon
subclass of: SO_0000010

856816
type: Gene
SIO_000068: ncbigene

position:327065:1
position: 327065
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:327451:1
position: 327451
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:327065-327451:1:exon

YER084W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER084W
product: uncharacterized protein
transcript id: NM_001270744.1
SIO_010081: YER084W
subclass of: SO_0000673
so part of: YER084W
location: <327065..>327451
location: region:327065-327451:1
so has part: feature:327065-327451:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:327065-327451:1:exon

YER084W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER084W
note: hypothetical protein; expressed at both mRNA and protein levels
codon start: 1
product: uncharacterized protein
translation: MEELICTYPYHSNLFMFLFLFFCPSKRARRGHPKFLFTLCYKSNHLIPKLLPPSLFTKRVMLNPSSHPPSPDFPTGSSASPRVKLRPSTLWAPPLTVSSDFAASSSSTAPVTVTDKPVTPAVSKRYQP
SIO_010081: YER084W
subclass of: SO_0000673
so part of: YER084W
location: 327065..327451
location: region:327065-327451:1
so has part: feature:327065-327451:1:exon

NP_001257673.1
type: Protein
SIO_000068: ncbiprotein

S000000886
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:327065-327451:1:exon

YER085C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER085C
so part of: sequence
location: complement(<327619..>328140)
location: region:327619-328140:-1
so has part: feature:327619-328140:-1:exon
subclass of: SO_0000010

856818
type: Gene
SIO_000068: ncbigene

position:327619:-1
position: 327619
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:328140:-1
position: 328140
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:327619-328140:-1:exon

YER085C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER085C
product: uncharacterized protein
transcript id: NM_001178976.3
SIO_010081: YER085C
subclass of: SO_0000673
so part of: YER085C
location: complement(<327619..>328140)
location: region:327619-328140:-1
so has part: feature:327619-328140:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:327619-328140:-1:exon

YER085C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER085C
codon start: 1
product: uncharacterized protein
translation: MNFKEPLVNFLKCVLNNINSAFSHRIDQLQLQLLRETNILRVLNRGIERLFSENPRTHSVSRIVVEKDVGCRIGRYVEGSKYELVESRAKEIQIYYERMVFEITQELKGDKRVFALIANLSQRYSAERKEIRNVKVHGGRPCNENEFQVIPIRFKPINLERRARLIRKKKTIN
SIO_010081: YER085C
subclass of: SO_0000673
so part of: YER085C
location: complement(327619..328140)
location: region:327619-328140:-1
so has part: feature:327619-328140:-1:exon

NP_011008.3
type: Protein
SIO_000068: ncbiprotein

S000000887
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:327619-328140:-1:exon

YER086W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISO1
gene: ILV1
locus tag: YER086W
gene synonym: ISO1
so part of: sequence
location: <328477..>330207
location: region:328477-330207:1
so has part: feature:328477-330207:1:exon
subclass of: SO_0000010

856819
type: Gene
SIO_000068: ncbigene

position:328477:1
position: 328477
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:330207:1
position: 330207
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:328477-330207:1:exon

YER086W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISO1
gene: ILV1
locus tag: YER086W
gene synonym: ISO1
product: threonine ammonia-lyase ILV1
transcript id: NM_001178977.1
SIO_010081: YER086W
subclass of: SO_0000673
so part of: YER086W
location: <328477..>330207
location: region:328477-330207:1
so has part: feature:328477-330207:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:328477-330207:1:exon

YER086W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISO1
gene: ILV1
locus tag: YER086W
gene synonym: ISO1
EC number: 4.3.1.19
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:genetic interaction:GO:0006567 threonine catabolic process [PMID:7042346]
experiment: EXISTENCE:mutant phenotype:GO:0004794 L-threonine ammonia-lyase activity [PMID:5345980]
experiment: EXISTENCE:mutant phenotype:GO:0009097 isoleucine biosynthetic process [PMID:5345980]
note: Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
codon start: 1
product: threonine ammonia-lyase ILV1
translation: MSATLLKQPLCTVVRQGKQSKVSGLNLLRLKAHLHRQHLSPSLIKLHSELKLDELQTDNTPDYVRLVLRSSVYDVINESPISQGVGLSSRLNTNVILKREDLLPVFSFKLRGAYNMIAKLDDSQRNQGVIACSAGNHAQGVAFAAKHLKIPATIVMPVCTPSIKYQNVSRLGSQVVLYGNDFDEAKAECAKLAEERGLTNIPPFDHPYVIAGQGTVAMEILRQVRTANKIGAVFVPVGGGGLIAGIGAYLKRVAPHIKIIGVETYDAATLHNSLQRNQRTPLPVVGTFADGTSVRMIGEETFRVAQQVVDEVVLVNTDEICAAVKDIFEDTRSIVEPSGALSVAGMKKYISTVHPEIDHTKNTYVPILSGANMNFDRLRFVSERAVLGEGKEVFMLVTLPDVPGAFKKMQKIIHPRSVTEFSYRYNEHRHESSSEVPKAYIYTSFSVVDREKEIKQVMQQLNALGFEAVDISDNELAKSHGRYLVGGASKVPNERIISFEFPERPGALTRFLGGLSDSWNLTLFHYRNHGADIGKVLAGISVPPRENLTFQKFLEDLGYTYHDETDNTVYQKFLKY
SIO_010081: YER086W
subclass of: SO_0000673
so part of: YER086W
location: 328477..330207
location: region:328477-330207:1
so has part: feature:328477-330207:1:exon

NP_011009.1
type: Protein
SIO_000068: ncbiprotein

S000000888
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:328477-330207:1:exon

YER087W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AIM10
locus tag: YER087W
so part of: sequence
location: <330576..>332306
location: region:330576-332306:1
so has part: feature:330576-332306:1:exon
subclass of: SO_0000010

856820
type: Gene
SIO_000068: ncbigene

position:330576:1
position: 330576
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332306:1
position: 332306
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:330576-332306:1:exon

YER087W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AIM10
locus tag: YER087W
product: putative proline--tRNA ligase AIM10
transcript id: NM_001178978.1
SIO_010081: YER087W
subclass of: SO_0000673
so part of: YER087W
location: <330576..>332306
location: region:330576-332306:1
so has part: feature:330576-332306:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:330576-332306:1:exon

YER087W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AIM10
locus tag: YER087W
EC number: 6.1.1.15
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
note: Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
codon start: 1
product: putative proline--tRNA ligase AIM10
translation: MLKYRTLSRSCHIFHPKSLSNNTLKSETTQELLQTVGFVRRSQVGLFQWLPLGLRSLNKVSNAIRNRMDSDGGAIEVSLSAISSKALWQATDRWNNSELFKLKDSKGKQYCLTATCEEDITDLMKNYIASYKDMPITIYQMTRKYRDEIRPRGGILRGREFLMKDAYSFASNEEDAFASFQKLDDTYNKIFKDLKIPFVSAWADSGDIGGEFSKEFHLIHESGEDTLMSCKHCGDISTLDMSQSYPEKDGQYSGDVDCKYALTKDHSTLICFYYPKDRQLNWNLALNAMDKDIDLTLRNKPNDHVLQVYEKDNEDIMFSKILRVMDCRLNSKSNFPDFPLKKYLKNNFGQISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNVKFVDKENKNETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWPAIMAPYKVSICTGPNNPENSQRLQDVKSELLNDPTMQNLQNDILDQFNEKLGIGARIKLSHAMGIPLCVIVGSKSWPNVEIEVRGIRWGEKDLWRKQFEKRCSELQWKCTKNEHGIEKHTVPIQHLAEVIGVLLKDM
SIO_010081: YER087W
subclass of: SO_0000673
so part of: YER087W
location: 330576..332306
location: region:330576-332306:1
so has part: feature:330576-332306:1:exon

NP_011010.1
type: Protein
SIO_000068: ncbiprotein

S000000889
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:330576-332306:1:exon

YER087C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEB1
alternative label: YER087C-A
gene: SBH1
locus tag: YER087C-B
gene synonym: SEB1; YER087C-A
so part of: sequence
location: complement(<332582..>332830)
location: region:332582-332830:-1
so has part: feature:332582-332830:-1:exon
subclass of: SO_0000010

856821
type: Gene
SIO_000068: ncbigene

position:332582:-1
position: 332582
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:332830:-1
position: 332830
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:332582-332830:-1:exon

YER087C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEB1
alternative label: YER087C-A
gene: SBH1
locus tag: YER087C-B
gene synonym: SEB1; YER087C-A
product: Arf family guanine nucleotide exchange factor SBH1
transcript id: NM_001180032.3
SIO_010081: YER087C-B
subclass of: SO_0000673
so part of: YER087C-B
location: complement(<332582..>332830)
location: region:332582-332830:-1
so has part: feature:332582-332830:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:332582-332830:-1:exon

YER087C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEB1
alternative label: YER087C-A
gene: SBH1
locus tag: YER087C-B
gene synonym: SEB1; YER087C-A
experiment: EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12750387]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:27831485]
experiment: EXISTENCE:direct assay:GO:0005784 Sec61 translocon complex [PMID:7758110|PMID:8612571]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31201345]
experiment: EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]
experiment: EXISTENCE:direct assay:GO:0015450 protein-transporting ATPase activity [PMID:7758110]
experiment: EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]
experiment: EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:19857245]
note: Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication
codon start: 1
product: Arf family guanine nucleotide exchange factor SBH1
translation: MSSPTPPGGQRTLQKRKQGSSQKVAASAPKKNTNSNNSILKIYSDEATGLRVDPLVVLFLAVGFIFSVVALHVISKVAGKLF
SIO_010081: YER087C-B
subclass of: SO_0000673
so part of: YER087C-B
location: complement(332582..332830)
location: region:332582-332830:-1
so has part: feature:332582-332830:-1:exon

NP_011011.3
type: Protein
SIO_000068: ncbiprotein

S000002128
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:332582-332830:-1:exon

YER088C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PBF2
gene: DOT6
locus tag: YER088C
gene synonym: PBF2
so part of: sequence
location: complement(<333176..>335188)
location: region:333176-335188:-1
so has part: feature:333176-335188:-1:exon
subclass of: SO_0000010

856822
type: Gene
SIO_000068: ncbigene

position:333176:-1
position: 333176
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:335188:-1
position: 335188
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:333176-335188:-1:exon

YER088C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PBF2
gene: DOT6
locus tag: YER088C
gene synonym: PBF2
product: Dot6p
transcript id: NM_001178979.3
SIO_010081: YER088C
subclass of: SO_0000673
so part of: YER088C
location: complement(<333176..>335188)
location: region:333176-335188:-1
so has part: feature:333176-335188:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:333176-335188:-1:exon

YER088C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PBF2
gene: DOT6
locus tag: YER088C
gene synonym: PBF2
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]
experiment: EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]
experiment: EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:9755194]
experiment: EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19158363]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9755194]
note: Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress
codon start: 1
product: Dot6p
translation: MSISTSLNSASIHLSSMDTHPQLHSLTRQPHSSSTAMSKNEAQESSPSLPASSSSSTSASASASSKNSSKNPSSWDPQDDLLLRHLKEVKKMGWKDISQYFPNRTPNACQFRWRRLKSGNLKSNKTALIDINTYTGPLKITHGDETANAQQKPSKKVEENVLTEDTAEFTTTSSIPIPSRKTSLPSFHASMSFSQSPSNVTPTTIVSNAASSMPFAPPTLPAALPHHPHQHLHHHPHHKTLKPRSNSHSFTNSLNQDPIVRSNDEEKYGFIPKVFVRSRRSSFAYPQQVAITTTPSSPNSSHVLLSSKSRRGSLANWSRRSSFNVSSNNTSRRSSMILAPNSVSNIFNVNNSGSNTASTSNTNSRRESVIKKEFQQRLNNLSNSGGPTSNNGPIFPNSYTFMDLPHSSSVSSSSTLHKSKRGSFSGHSMKSSCNPTNLWSKDEDALLMENKKRNLSVMELSILLPQRTEVEIQWRLNALSSDADMLSPTHSPQKTLSKKTCPRMFKSGSTTDDDKGSDKEDVMGDGSNDDDEDNVDPLHRAKQSSNKTVFSSSSSNISSKDVSPDPIFSPDPADDSSNTSDAGSRCTITSDTSSSAATMNRTPNSKNPQDIALLNNFRSEAITPRPKPSSTTTSITTETTNNMINHSSSTTTTTNNSPLPSINTIFKDML
SIO_010081: YER088C
subclass of: SO_0000673
so part of: YER088C
location: complement(333176..335188)
location: region:333176-335188:-1
so has part: feature:333176-335188:-1:exon

NP_011012.3
type: Protein
SIO_000068: ncbiprotein

S000000890
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:333176-335188:-1:exon

YER089C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PTC2
locus tag: YER089C
so part of: sequence
location: complement(<335946..>337340)
location: region:335946-337340:-1
so has part: feature:335946-337340:-1:exon
subclass of: SO_0000010

856823
type: Gene
SIO_000068: ncbigene

position:335946:-1
position: 335946
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:337340:-1
position: 337340
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:335946-337340:-1:exon

YER089C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PTC2
locus tag: YER089C
product: type 2C protein phosphatase PTC2
transcript id: NM_001178980.1
SIO_010081: YER089C
subclass of: SO_0000673
so part of: YER089C
location: complement(<335946..>337340)
location: region:335946-337340:-1
so has part: feature:335946-337340:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:335946-337340:-1:exon

YER089C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PTC2
locus tag: YER089C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10580002|PMID:9528768]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12477803|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12477803|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0035970 peptidyl-threonine dephosphorylation [PMID:12477803]
experiment: EXISTENCE:direct assay:GO:1990439 MAP kinase serine/threonine phosphatase activity [PMID:12477803]
experiment: EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:10580002]
experiment: EXISTENCE:mutant phenotype:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:9528768]
experiment: EXISTENCE:physical interaction:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:9528768]
note: Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
codon start: 1
product: type 2C protein phosphatase PTC2
translation: MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPIDLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKAGRSHLQ
SIO_010081: YER089C
subclass of: SO_0000673
so part of: YER089C
location: complement(335946..337340)
location: region:335946-337340:-1
so has part: feature:335946-337340:-1:exon

NP_011013.1
type: Protein
SIO_000068: ncbiprotein

S000000891
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:335946-337340:-1:exon

YER090W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TRP2
locus tag: YER090W
so part of: sequence
location: <337949..>339472
location: region:337949-339472:1
so has part: feature:337949-339472:1:exon
subclass of: SO_0000010

856824
type: Gene
SIO_000068: ncbigene

position:337949:1
position: 337949
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:339472:1
position: 339472
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:337949-339472:1:exon

YER090W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TRP2
locus tag: YER090W
product: anthranilate synthase TRP2
transcript id: NM_001178981.1
SIO_010081: YER090W
subclass of: SO_0000673
so part of: YER090W
location: <337949..>339472
location: region:337949-339472:1
so has part: feature:337949-339472:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:337949-339472:1:exon

YER090W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TRP2
locus tag: YER090W
EC number: 4.1.3.27
experiment: EXISTENCE:direct assay:GO:0004049 anthranilate synthase activity [PMID:3881257]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004049 anthranilate synthase activity [PMID:6323449]
experiment: EXISTENCE:mutant phenotype:GO:0000162 tryptophan biosynthetic process [PMID:8432699]
experiment: EXISTENCE:physical interaction:GO:0005950 anthranilate synthase complex [PMID:3881257]
note: Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
codon start: 1
product: anthranilate synthase TRP2
translation: MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA
SIO_010081: YER090W
subclass of: SO_0000673
so part of: YER090W
location: 337949..339472
location: region:337949-339472:1
so has part: feature:337949-339472:1:exon

NP_011014.1
type: Protein
SIO_000068: ncbiprotein

S000000892
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:337949-339472:1:exon

YER091C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MET6
locus tag: YER091C
so part of: sequence
location: complement(<339864..>342167)
location: region:339864-342167:-1
so has part: feature:339864-342167:-1:exon
subclass of: SO_0000010

856825
type: Gene
SIO_000068: ncbigene

position:339864:-1
position: 339864
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:342167:-1
position: 342167
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:339864-342167:-1:exon

YER091C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MET6
locus tag: YER091C
product: 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase
transcript id: NM_001178982.3
SIO_010081: YER091C
subclass of: SO_0000673
so part of: YER091C
location: complement(<339864..>342167)
location: region:339864-342167:-1
so has part: feature:339864-342167:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:339864-342167:-1:exon

YER091C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MET6
locus tag: YER091C
EC number: 2.1.1.14
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:mutant phenotype:GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity [PMID:3542720]
experiment: EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:1101032]
note: Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
codon start: 1
product: 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase
translation: MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN
SIO_010081: YER091C
subclass of: SO_0000673
so part of: YER091C
location: complement(339864..342167)
location: region:339864-342167:-1
so has part: feature:339864-342167:-1:exon

NP_011015.3
type: Protein
SIO_000068: ncbiprotein

S000000893
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:339864-342167:-1:exon

YER092W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: IES5
locus tag: YER092W
so part of: sequence
location: <342855..>343232
location: region:342855-343232:1
so has part: feature:342855-343232:1:exon
subclass of: SO_0000010

856827
type: Gene
SIO_000068: ncbigene

position:342855:1
position: 342855
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:343232:1
position: 343232
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:342855-343232:1:exon

YER092W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: IES5
locus tag: YER092W
product: Ies5p
transcript id: NM_001178983.3
SIO_010081: YER092W
subclass of: SO_0000673
so part of: YER092W
location: <342855..>343232
location: region:342855-343232:1
so has part: feature:342855-343232:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:342855-343232:1:exon

YER092W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: IES5
locus tag: YER092W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]
experiment: EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]
note: Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination
codon start: 1
product: Ies5p
translation: MPSKDPESVIDKEIRKISARNDELIKQDGTLKREYTTLLRKVSSVITVLNSIDDADTGSAETELPRLISQATVEKVPELKWYNDQISLITEKLEDDEDIEVPEELMDAYTLYKETPLLYNDTHTP
SIO_010081: YER092W
subclass of: SO_0000673
so part of: YER092W
location: 342855..343232
location: region:342855-343232:1
so has part: feature:342855-343232:1:exon

NP_011017.3
type: Protein
SIO_000068: ncbiprotein

S000000894
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:342855-343232:1:exon

YER093C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AVO3
gene: TSC11
locus tag: YER093C
gene synonym: AVO3
so part of: sequence
location: complement(<343320..>347612)
location: region:343320-347612:-1
so has part: feature:343320-347612:-1:exon
subclass of: SO_0000010

856828
type: Gene
SIO_000068: ncbigene

position:343320:-1
position: 343320
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:347612:-1
position: 347612
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:343320-347612:-1:exon

YER093C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AVO3
gene: TSC11
locus tag: YER093C
gene synonym: AVO3
product: TORC2 complex subunit TSC11
transcript id: NM_001178984.1
SIO_010081: YER093C
subclass of: SO_0000673
so part of: YER093C
location: complement(<343320..>347612)
location: region:343320-347612:-1
so has part: feature:343320-347612:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:343320-347612:-1:exon

YER093C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AVO3
gene: TSC11
locus tag: YER093C
gene synonym: AVO3
experiment: EXISTENCE:curator inference:GO:0031929 TOR signaling [PMID:12408816]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30969890]
experiment: EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15809876]
experiment: EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9804843]
experiment: EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15809876]
experiment: EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15809876]
experiment: EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:30969890]
experiment: EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16002396]
experiment: EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:30969890]
experiment: EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]
experiment: EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]
note: Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain
codon start: 1
product: TORC2 complex subunit TSC11
translation: MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKNITSSSPSTITNESSKRNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLNLKAEINNQYQELARLRKKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREIDNSIKRVEKHIFDLKQQFDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLTDQVTLDDEYLTTPTSGTERNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDTEKDLGDLENENQIFTSTTTEAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSEIRKDLVLTSFMSSIQNLLLNGNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISLAKDNSFQIEREQALKMVRRFIEYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCFVAPEMVKECRGMRVIEGFLQDYTSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTTVFSDTNTKSNVNVEKMQNASTLISITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQYLIDIFLDVLKIKPLPYKPRGRHSHSFKPIPSQYYKECMSVNQRLALIVLILENSEFVPHLLELLNEEDRDDHLVAKGRYLLTEYFNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFKKIAYKMNRNRNTIGMSGIDYAQNIKSFSKNIKENTLLREVDDFRFRRMVYDSKVLQTKDFTRWNWNIINELLEGPLLNKKQLEELVKSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQKYVQVGCQFFKTLTATPEGMKILMDDTKIIPQLASLMFRAMEGNISGNIFNKNKLREKIIFGYFKFIGILTQSKNGVHILTRWNFFTVIYKMFQFESKLGLEFLLLTIPELDLKYSSHCRVIIGKALVVANEKVRIEATKHIGDKLKELLSTKESDLKLKANKVKLQQFKMEMLTRQLYDLSPSVVAVADQALYECIVAGNGSEELGTSFRMFLNQMVFIRSPILFELLSRPYGFQLLNEINFVKEERDSWLSKKNIEYVHIVEEFLKKNESINAKSLTFQQKSRLPLHFYESLTKTEDGILLLSQTGDLVTFMNVIKKYVNGNNMATVENAKEILDLKAALWCVGFIGSTELGIGLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGLISMTREGCEILDEMGWNCCVSVQDEPIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFNKSDGDLIEKCLPIEFDLDKLLKEKDTAENPLNEKIITNKYDNDITSQTITVSGENSSLFANEGLSSPYVTQYRNDDDSIESKVLHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKMFFKVFNMMSKYRFKPHVRKFLCGLFINNRALENVIRHDNKRDKRPANFTR
SIO_010081: YER093C
subclass of: SO_0000673
so part of: YER093C
location: complement(343320..347612)
location: region:343320-347612:-1
so has part: feature:343320-347612:-1:exon

NP_011018.1
type: Protein
SIO_000068: ncbiprotein

S000000895
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:343320-347612:-1:exon

YER093C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GEP8
gene: AIM11
locus tag: YER093C-A
gene synonym: GEP8
so part of: sequence
location: complement(<347912..>348400)
location: region:347912-348400:-1
so has part: feature:347912-348400:-1:exon
subclass of: SO_0000010

856829
type: Gene
SIO_000068: ncbigene

position:347912:-1
position: 347912
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:348400:-1
position: 348400
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:347912-348400:-1:exon

YER093C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GEP8
gene: AIM11
locus tag: YER093C-A
gene synonym: GEP8
product: Aim11p
transcript id: NM_001180860.1
SIO_010081: YER093C-A
subclass of: SO_0000673
so part of: YER093C-A
location: complement(join(<347912..348201,348277..>348400))
location: region:347912-348400:-1
so has part: feature:348277-348400:-1:exon
so has part: feature:347912-348201:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:348277-348400:-1:exon

position:348277:-1
position: 348277
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:347912-348201:-1:exon

position:348201:-1
position: 348201
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER093C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GEP8
gene: AIM11
locus tag: YER093C-A
gene synonym: GEP8
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]
note: hypothetical protein; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; localizes to the peroxisome in glucose; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
codon start: 1
product: Aim11p
translation: MIEEKKELKKRRVLQMARFYGAAAFTLITMRLISRAIKVRKYVPSIFQQNYKLPPFSQRNEAMSALTYASAASIGTFSTLIFGFCWALDISTAREFVFKTREFMSLPQALETDTSMDEETSKLTKQLQDLLSSENNK
SIO_010081: YER093C-A
subclass of: SO_0000673
so part of: YER093C-A
location: complement(join(347912..348201,348277..348400))
location: region:347912-348400:-1
so has part: feature:348277-348400:-1:exon
so has part: feature:347912-348201:-1:exon

NP_011019.1
type: Protein
SIO_000068: ncbiprotein

S000002960
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:348277-348400:-1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:347912-348201:-1:exon

YER094C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SCS32
gene: PUP3
locus tag: YER094C
gene synonym: SCS32
so part of: sequence
location: complement(<348729..>349346)
location: region:348729-349346:-1
so has part: feature:348729-349346:-1:exon
subclass of: SO_0000010

856830
type: Gene
SIO_000068: ncbigene

position:348729:-1
position: 348729
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:349346:-1
position: 349346
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:348729-349346:-1:exon

YER094C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SCS32
gene: PUP3
locus tag: YER094C
gene synonym: SCS32
product: proteasome core particle subunit beta 3
transcript id: NM_001178985.3
SIO_010081: YER094C
subclass of: SO_0000673
so part of: YER094C
location: complement(<348729..>349346)
location: region:348729-349346:-1
so has part: feature:348729-349346:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:348729-349346:-1:exon

YER094C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SCS32
gene: PUP3
locus tag: YER094C
gene synonym: SCS32
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0005789 endoplasmic reticulum membrane [PMID:9087403]
experiment: EXISTENCE:curator inference:GO:0034515 proteasome storage granule [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]
experiment: EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]
experiment: EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]
experiment: EXISTENCE:genetic interaction:GO:0061133 endopeptidase activator activity [PMID:9207060]
note: Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10
codon start: 1
product: proteasome core particle subunit beta 3
translation: MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD
SIO_010081: YER094C
subclass of: SO_0000673
so part of: YER094C
location: complement(348729..349346)
location: region:348729-349346:-1
so has part: feature:348729-349346:-1:exon

NP_011020.3
type: Protein
SIO_000068: ncbiprotein

S000000896
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:348729-349346:-1:exon

YER095W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MUT5
gene: RAD51
locus tag: YER095W
gene synonym: MUT5
so part of: sequence
location: <349980..>351182
location: region:349980-351182:1
so has part: feature:349980-351182:1:exon
subclass of: SO_0000010

856831
type: Gene
SIO_000068: ncbigene

position:349980:1
position: 349980
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:351182:1
position: 351182
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:349980-351182:1:exon

YER095W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MUT5
gene: RAD51
locus tag: YER095W
gene synonym: MUT5
product: recombinase RAD51
transcript id: NM_001178986.3
SIO_010081: YER095W
subclass of: SO_0000673
so part of: YER095W
location: <349980..>351182
location: region:349980-351182:1
so has part: feature:349980-351182:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:349980-351182:1:exon

YER095W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MUT5
gene: RAD51
locus tag: YER095W
gene synonym: MUT5
experiment: EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:8066464]
experiment: EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11459983]
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9427283]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26540255]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:32083180]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:20371520|PMID:32083180]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:26540255]
experiment: EXISTENCE:direct assay:GO:0006310 DNA recombination [PMID:22955832]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:8066464]
experiment: EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:10506208]
experiment: EXISTENCE:direct assay:GO:0042148 strand invasion [PMID:8066464|PMID:9271413]
experiment: EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:1581961]
experiment: EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:25822194]
experiment: EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:32083180]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7026973]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:7026973]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767]
experiment: EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]
experiment: EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:31142613]
note: Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA
codon start: 1
product: recombinase RAD51
translation: MSQVQEQHISESQLQYGNGSLMSTVPADLSQSVVDGNGNGSSEDIEATNGSGDGGGLQEQAEAQGEMEDEAYDEAALGSFVPIEKLQVNGITMADVKKLRESGLHTAEAVAYAPRKDLLEIKGISEAKADKLLNEAARLVPMGFVTAADFHMRRSELICLTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQIPLDIGGGEGKCLYIDTEGTFRPVRLVSIAQRFGLDPDDALNNVAYARAYNADHQLRLLDAAAQMMSESRFSLIVVDSVMALYRTDFSGRGELSARQMHLAKFMRALQRLADQFGVAVVVTNQVVAQVDGGMAFNPDPKKPIGGNIMAHSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGDPREEDE
SIO_010081: YER095W
subclass of: SO_0000673
so part of: YER095W
location: 349980..351182
location: region:349980-351182:1
so has part: feature:349980-351182:1:exon

NP_011021.3
type: Protein
SIO_000068: ncbiprotein

S000000897
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:349980-351182:1:exon

YER096W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SHC1
locus tag: YER096W
so part of: sequence
location: <351698..>353236
location: region:351698-353236:1
so has part: feature:351698-353236:1:exon
subclass of: SO_0000010

856832
type: Gene
SIO_000068: ncbigene

position:351698:1
position: 351698
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:353236:1
position: 353236
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:351698-353236:1:exon

YER096W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SHC1
locus tag: YER096W
product: Shc1p
transcript id: NM_001178987.1
SIO_010081: YER096W
subclass of: SO_0000673
so part of: YER096W
location: <351698..>353236
location: region:351698-353236:1
so has part: feature:351698-353236:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:351698-353236:1:exon

YER096W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SHC1
locus tag: YER096W
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916]
experiment: EXISTENCE:direct assay:GO:0030437 ascospore formation [PMID:11918806]
experiment: EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:11918806]
experiment: EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:11918806]
note: Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
codon start: 1
product: Shc1p
translation: MSMTICSNTPGAYPEIGAYNEVDKQLESSGFSSDSSLILNKPEVRQYWSSVSSHISRSGDVFTNDKEKISSSIGEDAMDIDASPSLIEKYNSFPTRKILPEQDEFENDVEDDASSSLKEKSQGSCEIEIASEISSEILNGTSADGNSEFHDFAEPPPSQNESVALSFSQSNDLDFLNNPSGSGSSNDINRSTSSISLPRHVSLDFNVYNSLCLTNEVTASESHNVAKFHLGKKNKKSLLPRWKTIEMYGEVVKKTQDIYSNFQYAQYILRVGLDTEKLHELVKELEDESNSFSVDSLKEYLVNDAKVILKKLSAVGYPDAQYLLGDAYSSGVFGKIKNRRAFLLFSAAAKRMHIESVYRTAICYECGLGVTRNAPKAVNFLTFAATKNHPAAMYKLGVYSYHGLMGLPDDILTKMDGYRWLRRATSMASSFVCGAPFELANIYMTGYKDLIISDPDYAMALYEKAAALGHTESARILEDARRSGGFVSRGHPPSAQKYHKTSHEAVAAKKLI
SIO_010081: YER096W
subclass of: SO_0000673
so part of: YER096W
location: 351698..353236
location: region:351698-353236:1
so has part: feature:351698-353236:1:exon

NP_011022.1
type: Protein
SIO_000068: ncbiprotein

S000000898
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:351698-353236:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 353399..353735
location: region:353399-353735:1
so has part: feature:353399-353735:1:region

S000006915
type: SGD
SIO_000068: sgd

position:353399:1
position: 353399
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:353735:1
position: 353735
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353399-353735:1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS516; Autonomously Replicating Sequence
so part of: sequence
location: 353578..353636
location: region:353578-353636:1
so has part: feature:353578-353636:1:region

S000077388
type: SGD
SIO_000068: sgd

position:353578:1
position: 353578
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:353636:1
position: 353636
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:353578-353636:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 354136..354850
location: region:354136-354850:1
so has part: feature:354136-354850:1:region

S000006916
type: SGD
SIO_000068: sgd

position:354136:1
position: 354136
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:354850:1
position: 354850
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354136-354850:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(354360..354730)
location: region:354360-354730:-1
so has part: feature:354360-354730:-1:region

S000006908
type: SGD
SIO_000068: sgd

position:354360:-1
position: 354360
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:354730:-1
position: 354730
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354360-354730:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(354851..354917)
location: region:354851-354917:-1
so has part: feature:354851-354917:-1:region

S000006905
type: SGD
SIO_000068: sgd

position:354851:-1
position: 354851
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:354917:-1
position: 354917
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354851-354917:-1:region

YNCE0018W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0018W
so part of: sequence
location: 354934..355005
location: region:354934-355005:1
so has part: feature:354934-355005:1:exon
subclass of: SO_0000663

856833
type: Gene
SIO_000068: ncbigene

position:354934:1
position: 354934
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:355005:1
position: 355005
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:354934-355005:1:exon

YNCE0018W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0018W
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p
SIO_010081: YNCE0018W
subclass of: SO_0000673
so part of: YNCE0018W
location: 354934..355005
location: region:354934-355005:1
so has part: feature:354934-355005:1:exon

S000006551
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:354934-355005:1:exon

YER098W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBP9
locus tag: YER098W
so part of: sequence
location: <355466..>357730
location: region:355466-357730:1
so has part: feature:355466-357730:1:exon
subclass of: SO_0000010

856835
type: Gene
SIO_000068: ncbigene

position:355466:1
position: 355466
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:357730:1
position: 357730
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:355466-357730:1:exon

YER098W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBP9
locus tag: YER098W
product: putative ubiquitin-specific protease UBP9
transcript id: NM_001178989.1
SIO_010081: YER098W
subclass of: SO_0000673
so part of: YER098W
location: <355466..>357730
location: region:355466-357730:1
so has part: feature:355466-357730:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:355466-357730:1:exon

YER098W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBP9
locus tag: YER098W
EC number: 3.4.19.12
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
note: Putative ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication
codon start: 1
product: putative ubiquitin-specific protease UBP9
translation: MIKRWLSVNRKKSHPEKNTQGNDEINRKATSLKKTKGSGDPSIAKSPSAKSSTSSIPSNLASHERRSKFSSQTDNLAGNKHYHEHYHNMASTSDEREYDSSTTYEDRAFDTESSILFTTITDLMPYGDGSNKVFGYENFGNTCYCNSVLQCLYNIPEFRCNVLRYPERVAAVNRIRKSDLKGSKIRVFTNESFETSTNSGNSNTGYQSNDNEDAHNHHHLQQSDQDNSSSSTQEKQNNFERKRNSFMGFGKDKSNYKDSAKKDDNNEMERPQPVHTVVMASDTLTEKLHEGCKKIIVGRPLLKQSDSLSKASTTDCQANSHCQCDSQGSRITSVDDDVLVNPESCNDAVNNSNNNKENTFPTSEQRKKAALIRGPVLNVDHLLYPTEEATLYNGLKDIFESITENLSLTGIVSPTEFVKILKKENVLFNTMMQQDAHEFLNFLLNDFSEYIQRNNPRMRFGPQKTDNSNDNFITDLFKGTLTNRIKCLTCDNITSRDEPFLDFPIEVQGDEETDIQKMLKSYHQREMLNGVNKFYCNKCYGLQEAERMVGLKQLPHILSLHLKRFKYSEEQKSNIKLFNKILYPLTLDVSSTFNTSVYKKYELSGVVIHMGSGPQHGHYVCICRNEKFGWLLYDDETVESIKEETVLQFTGHPGDQTTAYVLFYKETQADKTENQNENIDTSSQDQMQTDNNIEQLIKCDDWLRDRKLRAAANIERKKTLGNIPEVKTAETKTPLNDKKRNKQKRKSRILSFIK
SIO_010081: YER098W
subclass of: SO_0000673
so part of: YER098W
location: 355466..357730
location: region:355466-357730:1
so has part: feature:355466-357730:1:exon

NP_011024.1
type: Protein
SIO_000068: ncbiprotein

S000000900
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:355466-357730:1:exon

YER099C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PRS2
locus tag: YER099C
so part of: sequence
location: complement(<358105..>359061)
location: region:358105-359061:-1
so has part: feature:358105-359061:-1:exon
subclass of: SO_0000010

856836
type: Gene
SIO_000068: ncbigene

position:358105:-1
position: 358105
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:359061:-1
position: 359061
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:358105-359061:-1:exon

YER099C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PRS2
locus tag: YER099C
product: ribose phosphate diphosphokinase subunit PRS2
transcript id: NM_001178990.3
SIO_010081: YER099C
subclass of: SO_0000673
so part of: YER099C
location: complement(<358105..>359061)
location: region:358105-359061:-1
so has part: feature:358105-359061:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:358105-359061:-1:exon

YER099C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PRS2
locus tag: YER099C
EC number: 2.7.6.1
experiment: EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]
experiment: EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]
experiment: EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]
experiment: EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:15470112]
note: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
codon start: 1
product: ribose phosphate diphosphokinase subunit PRS2
translation: MSTNSIKLLAGNSHPGLAELISQRLGVPLSKVGVYQYSNKETSVTIGESIRDEDVYIIQTGYGEHEINDFLMELLILIHACKTASVRRITAVIPNFPYARQDKKDKSRAPITAKLIANLLETAGCDHVITMDLHASQIQGFFHIPVDNLYGEPSVLNYIRTKTDFNNAILVSPDAGGAKRVASLADKLDMNFALIHKERQKANEVSRMLLVGDVAGKSCLLIDDMADTCGTLVKACDTLMDHGAKEVIAIVTHGIFSGSAREKLINSRLSRIVCTNTVPVDLDLDIVDQVDISPTIAEAIRRLHNGESVSYLFTHAPV
SIO_010081: YER099C
subclass of: SO_0000673
so part of: YER099C
location: complement(358105..359061)
location: region:358105-359061:-1
so has part: feature:358105-359061:-1:exon

NP_011025.3
type: Protein
SIO_000068: ncbiprotein

S000000901
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:358105-359061:-1:exon

YER100W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DOA2
gene: UBC6
locus tag: YER100W
gene synonym: DOA2
so part of: sequence
location: <359562..>360314
location: region:359562-360314:1
so has part: feature:359562-360314:1:exon
subclass of: SO_0000010

856837
type: Gene
SIO_000068: ncbigene

position:359562:1
position: 359562
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:360314:1
position: 360314
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:359562-360314:1:exon

YER100W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DOA2
gene: UBC6
locus tag: YER100W
gene synonym: DOA2
product: E2 ubiquitin-conjugating protein UBC6
transcript id: NM_001178991.3
SIO_010081: YER100W
subclass of: SO_0000673
so part of: YER100W
location: <359562..>360314
location: region:359562-360314:1
so has part: feature:359562-360314:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:359562-360314:1:exon

YER100W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DOA2
gene: UBC6
locus tag: YER100W
gene synonym: DOA2
EC number: 2.3.2.23
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:8396728]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8396728]
experiment: EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:8396728]
experiment: EXISTENCE:genetic interaction:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:8396728|PMID:8641272|PMID:8781238]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:19345192]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18191224|PMID:8396728]
experiment: EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:8396728]
experiment: EXISTENCE:mutant phenotype:GO:0030433 ubiquitin-dependent ERAD pathway [PMID:18191224|PMID:8393731|PMID:8641272|PMID:8781238]
note: Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD
codon start: 1
product: E2 ubiquitin-conjugating protein UBC6
translation: MATKQAHKRLTKEYKLMVENPPPYILARPNEDNILEWHYIITGPADTPYKGGQYHGTLTFPSDYPYKPPAIRMITPNGRFKPNTRLCLSMSDYHPDTWNPGWSVSTILNGLLSFMTSDEATTGSITTSDHQKKTLARNSISYNTFQNVRFKLIFPEVVQENVETLEKRKLDEGDAANTGDETEDPFTKAAKEKVISLEEILDPEDRIRAEQALRQSENNSKKDGKEPNDSSSMVYIGIAIFLFLVGLFMK
SIO_010081: YER100W
subclass of: SO_0000673
so part of: YER100W
location: 359562..360314
location: region:359562-360314:1
so has part: feature:359562-360314:1:exon

NP_011026.3
type: Protein
SIO_000068: ncbiprotein

S000000902
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:359562-360314:1:exon

YER101C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AST2
locus tag: YER101C
so part of: sequence
location: complement(<360502..>361794)
location: region:360502-361794:-1
so has part: feature:360502-361794:-1:exon
subclass of: SO_0000010

856838
type: Gene
SIO_000068: ncbigene

position:360502:-1
position: 360502
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:361794:-1
position: 361794
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:360502-361794:-1:exon

YER101C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AST2
locus tag: YER101C
product: Ast2p
transcript id: NM_001178992.1
SIO_010081: YER101C
subclass of: SO_0000673
so part of: YER101C
location: complement(<360502..>361794)
location: region:360502-361794:-1
so has part: feature:360502-361794:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:360502-361794:-1:exon

YER101C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AST2
locus tag: YER101C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006612 protein targeting to membrane [PMID:7822420]
note: Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
codon start: 1
product: Ast2p
translation: MAEKILENKDPKLEAMTVDHEVSAPKPIPVDEPTLTRVARPLRHVRHIPVKSLVFHSKHGPITFSYENKIKLPISKNKLVVQVNYVGLNPVDMKIRNGYTKPIYGEAGIGREYSGVITHVGDNLTNRWNVGDDVYGIYYHPKLAIGALQSSLLIDPRVDPILMRPKNTLSPEKAAGSLFCLGTALNLLAQLKEKDQLNTESNVLINGGTSSVGMFAIQLLKRYYKVSKKLVVVTSGNGAAVLSEHFPDLKDEIIFINYLSCRGKSSKPLRRMLDTGKVVDYDDFNTLKETEDYTQGKFNVVLDFIGGYDILSHSSSLIHAKGAYITTVGDYVGNYKKDVFDSWDNPSANARKMFGSMLWSYDYSHFYFDPNIKIIPKKNDWIHECGKLLNEGVVDCVVDKVYSWKNFKEAFSYMATQRAQGKLIMKVEGF
SIO_010081: YER101C
subclass of: SO_0000673
so part of: YER101C
location: complement(360502..361794)
location: region:360502-361794:-1
so has part: feature:360502-361794:-1:exon

NP_011027.1
type: Protein
SIO_000068: ncbiprotein

S000000903
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:360502-361794:-1:exon

YER102W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS8B
locus tag: YER102W
so part of: sequence
location: <363100..>363702
location: region:363100-363702:1
so has part: feature:363100-363702:1:exon
subclass of: SO_0000010

856839
type: Gene
SIO_000068: ncbigene

position:363100:1
position: 363100
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:363702:1
position: 363702
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:363100-363702:1:exon

YER102W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS8B
locus tag: YER102W
product: ribosomal 40S subunit protein S8B
transcript id: NM_001178993.1
SIO_010081: YER102W
subclass of: SO_0000673
so part of: YER102W
location: <363100..>363702
location: region:363100-363702:1
so has part: feature:363100-363702:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:363100-363702:1:exon

YER102W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS8B
locus tag: YER102W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:18782943]
experiment: EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]
experiment: EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 40S subunit protein S8B
translation: MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGGNKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAIVQIDATPFRQWFEAHYGQTLGKKKNVKEEETVAKSKNAERKWAARAASAKIESSVESQFSAGRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK
SIO_010081: YER102W
subclass of: SO_0000673
so part of: YER102W
location: 363100..363702
location: region:363100-363702:1
so has part: feature:363100-363702:1:exon

NP_011028.1
type: Protein
SIO_000068: ncbiprotein

S000000904
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:363100-363702:1:exon

YER103W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YG107
gene: SSA4
locus tag: YER103W
gene synonym: YG107
so part of: sequence
location: <364589..>366517
location: region:364589-366517:1
so has part: feature:364589-366517:1:exon
subclass of: SO_0000010

856840
type: Gene
SIO_000068: ncbigene

position:364589:1
position: 364589
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:366517:1
position: 366517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:364589-366517:1:exon

YER103W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YG107
gene: SSA4
locus tag: YER103W
gene synonym: YG107
product: Hsp70 family chaperone SSA4
transcript id: NM_001178994.3
SIO_010081: YER103W
subclass of: SO_0000673
so part of: YER103W
location: <364589..>366517
location: region:364589-366517:1
so has part: feature:364589-366517:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:364589-366517:1:exon

YER103W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YG107
gene: SSA4
locus tag: YER103W
gene synonym: YG107
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11279056]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11279056]
experiment: EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:9789005]
experiment: EXISTENCE:genetic interaction:GO:0051082 unfolded protein binding [PMID:9789005]
experiment: EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]
note: Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
codon start: 1
product: Hsp70 family chaperone SSA4
translation: MSKAVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQAAMNPHNTVFDAKRLIGRKFDDPEVTNDAKHYPFKVIDKGGKPVVQVEYKGETKTFTPEEISSMILTKMKETAENFLGTEVKDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKSQKEHNVLIFDLGGGTFDVSLLSIDEGVFEVKATAGDTHLGGEDFDSRLVNFLAEEFKRKNKKDLTTNQRSLRRLRTAAERAKRTLSSSAQTSIEIDSLFEGIDFYTSITRARFEELCADLFRSTLEPVEKVLADSKLDKSQIDEIVLVGGSTRIPKVQKLVSDFFNGKEPNRSINPDEAVAYGAAVQAAILTGDQSSTTQDLLLLDVAPLSLGIETAGGIMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERTRTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAVEKGTGKSNKITITNDKGRLSKEDIDKMVAEAEKFKAEDEQEAQRVQAKNQLESYAFTLKNSVSENNFKEKVGEEDARKLEAAAQDAINWLDASQAASTEEYKERQKELEGVANPIMSKFYGAAGGAPGAGPVPGAGAGPTGAPDNGPTVEEVD
SIO_010081: YER103W
subclass of: SO_0000673
so part of: YER103W
location: 364589..366517
location: region:364589-366517:1
so has part: feature:364589-366517:1:exon

NP_011029.3
type: Protein
SIO_000068: ncbiprotein

S000000905
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:364589-366517:1:exon

YER104W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTT105
locus tag: YER104W
so part of: sequence
location: <366802..>367428
location: region:366802-367428:1
so has part: feature:366802-367428:1:exon
subclass of: SO_0000010

856841
type: Gene
SIO_000068: ncbigene

position:366802:1
position: 366802
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:367428:1
position: 367428
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:366802-367428:1:exon

YER104W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTT105
locus tag: YER104W
product: Rtt105p
transcript id: NM_001178995.3
SIO_010081: YER104W
subclass of: SO_0000673
so part of: YER104W
location: <366802..>367428
location: region:366802-367428:1
so has part: feature:366802-367428:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:366802-367428:1:exon

YER104W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTT105
locus tag: YER104W
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:30065069]
experiment: EXISTENCE:direct assay:GO:0140597 protein carrier chaperone [PMID:30065069]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:30065069]
experiment: EXISTENCE:mutant phenotype:GO:0010526 negative regulation of transposition, RNA-mediated [PMID:11779788]
note: Chaperone for Replication Protein A complex (RPA); involved in nuclear import of RPA and its binding to ssDNA at replication forks; has a role in regulation of Ty1 transposition
codon start: 1
product: Rtt105p
translation: MYSNHNLNSDDCCFDWNEEKAAELQRTGVSFDRSLTPQSLRTSTRRLSEENKQQSGTMHIDTSPSVVSDIISSRRDRSQDFFGPHSSSPIAPSERQRADQRSRLESMRLTRRRDKMTKVRGGLEKMEEMIMQGEHLREMQRLKQEAQKNALPSDMAEYMEWQNNEDLEDDELLAFIEKQETYKNELEHFLNNANKNVYENNSYPNSHT
SIO_010081: YER104W
subclass of: SO_0000673
so part of: YER104W
location: 366802..367428
location: region:366802-367428:1
so has part: feature:366802-367428:1:exon

NP_011030.3
type: Protein
SIO_000068: ncbiprotein

S000000906
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:366802-367428:1:exon

YER105C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NUP157
locus tag: YER105C
so part of: sequence
location: complement(<367838..>372013)
location: region:367838-372013:-1
so has part: feature:367838-372013:-1:exon
subclass of: SO_0000010

856842
type: Gene
SIO_000068: ncbigene

position:367838:-1
position: 367838
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:372013:-1
position: 372013
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:367838-372013:-1:exon

YER105C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NUP157
locus tag: YER105C
product: Nup157p
transcript id: NM_001178996.1
SIO_010081: YER105C
subclass of: SO_0000673
so part of: YER105C
location: complement(<367838..>372013)
location: region:367838-372013:-1
so has part: feature:367838-372013:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:367838-372013:-1:exon

YER105C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NUP157
locus tag: YER105C
experiment: EXISTENCE:curator inference:GO:0006913 nucleocytoplasmic transport [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24062435]
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:24062435]
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]
experiment: EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:19414608]
experiment: EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:19414608]
experiment: EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20098417|PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
note: Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication
codon start: 1
product: Nup157p
translation: MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSSRSFLSERKTRKDVLNKYGEAGNTIESELRDVTTHVKISGLTSSEPLQLASEFVQDLSFRDRNTPILDNPDYYSKGLDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIKSDMGIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVWELQYNCSENLFNSKSNKICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAGTEEETISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLLSNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSISSSLEQNKSFIIGHHPLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANSGELSKGITNKALLENKEEHKLYVSAPDYGILKNYGKYVENTALLDTTDEIKEIVPLTRSFNYTSTPQGYANVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSYGLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLFDKSGECDGIVLSPRFYGSALLITRLFSQIWEERVFVFKRASKTEKMDAFGISITRPQVEYYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAESIAMNALILLINSIKDALSLINVFYEDIDAFKSLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNAKTKQLIKEILIEVVNANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEMIDSKISRNHLDTAIDLYERCAENIELCELRRVVDIMVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRGCNTADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSPSIANISIFSPASSLKKRVYSVIMNSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEHFLEAADVLYALASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDIASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVLPLSDLFNDCADPLDYYEIKLRIFKVSQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIRIGKTTRDTDVVFPVHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEMVWLIKDWYQSDSDLRGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK
SIO_010081: YER105C
subclass of: SO_0000673
so part of: YER105C
location: complement(367838..372013)
location: region:367838-372013:-1
so has part: feature:367838-372013:-1:exon

NP_011031.1
type: Protein
SIO_000068: ncbiprotein

S000000907
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:367838-372013:-1:exon

YER106W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MAM1
locus tag: YER106W
so part of: sequence
location: <372326..>373234
location: region:372326-373234:1
so has part: feature:372326-373234:1:exon
subclass of: SO_0000010

856843
type: Gene
SIO_000068: ncbigene

position:372326:1
position: 372326
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:373234:1
position: 373234
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:372326-373234:1:exon

YER106W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MAM1
locus tag: YER106W
product: Mam1p
transcript id: NM_001178997.1
SIO_010081: YER106W
subclass of: SO_0000673
so part of: YER106W
location: <372326..>373234
location: region:372326-373234:1
so has part: feature:372326-373234:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:372326-373234:1:exon

YER106W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MAM1
locus tag: YER106W
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:12663816|PMID:11163190|PMID:23861669]
experiment: EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:12689592]
experiment: EXISTENCE:direct assay:GO:0045859 regulation of protein kinase activity [PMID:27491543]
experiment: EXISTENCE:genetic interaction:GO:0010789 meiotic sister chromatid cohesion involved in meiosis I [PMID:15062096]
experiment: EXISTENCE:genetic interaction:GO:0051455 monopolar spindle attachment to meiosis I kinetochore [PMID:23861669]
experiment: EXISTENCE:mutant phenotype:GO:0010789 meiotic sister chromatid cohesion involved in meiosis I [PMID:15062096]
experiment: EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]
experiment: EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:11163190]
experiment: EXISTENCE:mutant phenotype:GO:0051455 monopolar spindle attachment to meiosis I kinetochore [PMID:11163190]
note: Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division
codon start: 1
product: Mam1p
translation: MREKRTISNKDTNYLKFPNKLQRYSRFLSRKISNTSPEKQPKKNIKEHCLSSYHKEHSVKPKQNSGNVAAKEDKDTQHLQNNVANEEATECLTRSNLKKLQEKIFDRELNDIACDHCLCSTENRRDIKYSRLWFLFELEMSENWNENLRLSCYNKYVYSAIDESWKMENILLKEQEKHYEYFPIGQLLIPNNIDYTNKQKRKENIEDLTIEIDSIIETNHQKKRFLPQSVLIKREDEIAFDDFHLDARKVLNDLSATSENPFSSSPNTKKIKSKGKTLEVVPKKKNKKIIGALERKLHIDEN
SIO_010081: YER106W
subclass of: SO_0000673
so part of: YER106W
location: 372326..373234
location: region:372326-373234:1
so has part: feature:372326-373234:1:exon

NP_011032.1
type: Protein
SIO_000068: ncbiprotein

S000000908
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:372326-373234:1:exon

YER107C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: RAE1
gene: GLE2
locus tag: YER107C
gene synonym: RAE1
so part of: sequence
location: complement(<373448..>374545)
location: region:373448-374545:-1
so has part: feature:373448-374545:-1:exon
subclass of: SO_0000010

856844
type: Gene
SIO_000068: ncbigene

position:373448:-1
position: 373448
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:374545:-1
position: 374545
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:373448-374545:-1:exon

YER107C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: RAE1
gene: GLE2
locus tag: YER107C
gene synonym: RAE1
product: RNA export factor GLE2
transcript id: NM_001178998.3
SIO_010081: YER107C
subclass of: SO_0000673
so part of: YER107C
location: complement(<373448..>374545)
location: region:373448-374545:-1
so has part: feature:373448-374545:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:373448-374545:-1:exon

YER107C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: RAE1
gene: GLE2
locus tag: YER107C
gene synonym: RAE1
experiment: EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:8970155]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15210706]
experiment: EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20098417|PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8970155]
experiment: EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:28776765]
experiment: EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:9725905]
experiment: EXISTENCE:mutant phenotype:GO:2000728 regulation of mRNA export from nucleus in response to heat stress [PMID:15210706]
note: RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
codon start: 1
product: RNA export factor GLE2
translation: MSFFNRSNTTSALGTSTAMANEKDLANDIVINSPAEDSISDIAFSPQQDFMFSASSWDGKVRIWDVQNGVPQGRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQTQQIGMHSAPIKVLRFVQCGPSNTECIVTGSWDKTIKYWDMRQPQPVSTVMMPERVYSMDNKQSLLVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACYNEADGYAIGSVEGRCSIRYIDDGMQKKSGFSFKCHRQTNPNRAPGSNGQSLVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYALSYDWHQGHMGNRPDYPNVIRLHATTDEEVKEKKKR
SIO_010081: YER107C
subclass of: SO_0000673
so part of: YER107C
location: complement(373448..374545)
location: region:373448-374545:-1
so has part: feature:373448-374545:-1:exon

NP_011033.3
type: Protein
SIO_000068: ncbiprotein

S000000909
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:373448-374545:-1:exon

YER109C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PHD5
alternative label: STA10
alternative label: YER108C
gene: FLO8
locus tag: YER109C
gene synonym: PHD5; STA10; YER108C
pseudo: true
so part of: sequence
location: complement(375215..377614)
location: region:375215-377614:-1
so has part: feature:375215-377614:-1:exon

856845
type: Gene
SIO_000068: ncbigene

position:375215:-1
position: 375215
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:377614:-1
position: 377614
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:375215-377614:-1:exon

YER109C
type: Miscellaneous Feature
subclass of: SO_0000001
RO_0002162: 559292
alternative label: PHD5
alternative label: STA10
alternative label: YER108C
gene: FLO8
locus tag: YER109C
gene synonym: PHD5; STA10; YER108C
experiment: EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12024012]
experiment: EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10515942]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12024012|PMID:8913742|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12024012]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10064592|PMID:12024012|PMID:10591965|PMID:16568252|P MID:10373537]
experiment: EXISTENCE:mutant phenotype:GO:1900189 positive regulation of cell adhesion involved in single-species biofilm formation [PMID:18202364]
note: Transcription factor; required for flocculation, diploid filamentous growth, and haploid invasive growth; forms a heterodimer with Mss11p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1; S. cerevisiae genome reference strain S288C contains an internal in-frame stop at codon 142, which in other strains encodes tryptophan
pseudo: true
SIO_010081: YER109C
subclass of: SO_0000673
so part of: YER109C
location: complement(375215..377614)
location: region:375215-377614:-1
so has part: feature:375215-377614:-1:exon

S000000911
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:375215-377614:-1:exon

YER110C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YRB4
gene: KAP123
locus tag: YER110C
gene synonym: YRB4
so part of: sequence
location: complement(<378762..>382103)
location: region:378762-382103:-1
so has part: feature:378762-382103:-1:exon
subclass of: SO_0000010

856846
type: Gene
SIO_000068: ncbigene

position:378762:-1
position: 378762
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:382103:-1
position: 382103
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:378762-382103:-1:exon

YER110C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YRB4
gene: KAP123
locus tag: YER110C
gene synonym: YRB4
product: Kap123p
transcript id: NM_001179000.1
SIO_010081: YER110C
subclass of: SO_0000673
so part of: YER110C
location: complement(<378762..>382103)
location: region:378762-382103:-1
so has part: feature:378762-382103:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:378762-382103:-1:exon

YER110C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YRB4
gene: KAP123
locus tag: YER110C
gene synonym: YRB4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9238021|PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9238021|PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:9321403]
experiment: EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:11694505]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:9321403]
experiment: EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11352936]
experiment: EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11694505]
experiment: EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9321403]
experiment: EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]
experiment: EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:9182759]
note: Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
codon start: 1
product: Kap123p
translation: MDQQFLSQLEQTLHAITSGVGLKEATKTLQTQFYTQPTTLPALIHILQNGSDDSLKQLAGVEARKLVSKHWNAIDESTRASIKTSLLQTAFSEPKENVRHSNARVIASIGTEELDGNKWPDLVPNLIQTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALFSQTINDPSSLEIRSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLNDFLLLDSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLSYRKSKVSQSKLGPEITVAALKVACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSELPPSQVASVIVEHIPAMLQSANVFERRAILLAISVAVTGSPDYILSQFDKIIPATINGLKDTEPIVKLAALKCIHQLTTDLQDEVAKFHEEYLPLIIDIIDSAKNIVIYNYATVALDGLLEFIAYDAIAKYLDPLMNKLFYMLESNESSKLRCAVVSAIGSAAFAAGSAFIPYFKTSVHYLEKFIQNCSQIEGMSEDDIELRANTFENISTMARAVRSDAFAEFAEPLVNSAYEAIKTDSARLRESGYAFIANLAKVYGENFAPFLKTILPEIFKTLELDEYQFNFDGDAEDLAAFADSANEEELQNKFTVNTGISYEKEVASAALSELALGTKEHFLPYVEQSLKVLNEQVDESYGLRETALNTIWNVVKSVLLASKVEPESYPKGIPASSYVNADVLAVIQAARETSMGNLSDEFETSMVITVMEDFANMIKQFGAIIIMDNGDSSMLEALCMQVLSVLKGTHTCQTIDIEEDVPRDEELDASETEATLQDVALEVLVSLSQALAGDFAKVFDNFRPVVFGLFQSKSKNKRSSAVGAASELALGMKEQNPFVHEMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQKALAAEDDEATREIIDRAYANASGCVARMALKNSALVPLEQTVPALLAHLPLNTGFEEYNPIFELIMKLYQENSPVITNETPRIIEIFSAVFTKENDRIKLEKESTLGREENMERLKQFQTEEMKHKVIELLKYLNTTYNGIVAQNPVLAAVIA
SIO_010081: YER110C
subclass of: SO_0000673
so part of: YER110C
location: complement(378762..382103)
location: region:378762-382103:-1
so has part: feature:378762-382103:-1:exon

NP_011035.1
type: Protein
SIO_000068: ncbiprotein

S000000912
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:378762-382103:-1:exon

YER111C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ART1
gene: SWI4
locus tag: YER111C
gene synonym: ART1
so part of: sequence
location: complement(<382595..>385876)
location: region:382595-385876:-1
so has part: feature:382595-385876:-1:exon
subclass of: SO_0000010

856847
type: Gene
SIO_000068: ncbigene

position:382595:-1
position: 382595
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:385876:-1
position: 385876
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:382595-385876:-1:exon

YER111C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ART1
gene: SWI4
locus tag: YER111C
gene synonym: ART1
product: SBF complex DNA-binding subunit SWI4
transcript id: NM_001179001.1
SIO_010081: YER111C
subclass of: SO_0000673
so part of: YER111C
location: complement(<382595..>385876)
location: region:382595-385876:-1
so has part: feature:382595-385876:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:382595-385876:-1:exon

YER111C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ART1
gene: SWI4
locus tag: YER111C
gene synonym: ART1
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]
experiment: EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:1832338|PMID:2689885|PMID:8423776]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2649246|PMID:8423776]
experiment: EXISTENCE:mutant phenotype:GO:0033309 SBF transcription complex [PMID:8423776]
experiment: EXISTENCE:mutant phenotype:GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress [PMID:20641022]
experiment: EXISTENCE:mutant phenotype:GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle [PMID:2649246|PMID:3542227]
experiment: EXISTENCE:physical interaction:GO:0033309 SBF transcription complex [PMID:1465410]
note: DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p
codon start: 1
product: SBF complex DNA-binding subunit SWI4
translation: MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSETDVYECYIRGFETKIVMRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGGYGRFQGTWIPLDSAKFLVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTKITSPSSYNKTPRKKNSSSSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVNSSMNIMNNNDNHTTMNFNNDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQKPLQFFPIPTNLQNKNVALNNPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPMQSQQQQQHHHEYLTNNFNHSMMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLMKQPLLWQSFQNPNDHHNEYCDSNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMTPFSAGNTSSQNKLENKMTDQEYKQTILTILSSERSSDVDQALLATLYPAPKNFNINFEIDDQGHTPLHWATAMANIPLIKMLITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEIISILKICLITPDVNGRLPFHYLIELSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICLNYQDNIGNTPLHLSALNLNFEVYNRLVYLGASTDILNLDNESPASIMNKFNTPAGGSNSRNNNTKADRKLARNLPQKNYYQQQQQQQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKTDSEVNESQYLHSNQPNSTNMNTIMEDLSNINSFVTSSVIKDIKSTPSKILENSPILYRRRSQSISDEKEKAKDNENQVEKKKDPLNSVKTAMPSLESPSSLLPIQMSPLGKYSKPLSQQINKLNTKVSSLQRIMGEEIKNLDNEVVETESSISNNKKRLITIAHQIEDAFDSVSNKTPINSISDLQSRIKETSSKLNSEKQNFIQSLEKSQALKLATIVQDEESKVDMNTNSSSHPEKQEDEEPIPKSTSETSSPKNTKADAKFSNTVQESYDVNETLRLATELTILQFKRRMTTLKISEAKSKINSSVKLDKYRNLIGITIENIDSKLDDIEKDLRANA
SIO_010081: YER111C
subclass of: SO_0000673
so part of: YER111C
location: complement(382595..385876)
location: region:382595-385876:-1
so has part: feature:382595-385876:-1:exon

NP_011036.1
type: Protein
SIO_000068: ncbiprotein

S000000913
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:382595-385876:-1:exon

YER112W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SDB23
alternative label: USS1
gene: LSM4
locus tag: YER112W
gene synonym: SDB23; USS1
so part of: sequence
location: <387232..>387795
location: region:387232-387795:1
so has part: feature:387232-387795:1:exon
subclass of: SO_0000010

856848
type: Gene
SIO_000068: ncbigene

position:387232:1
position: 387232
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:387795:1
position: 387795
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387232-387795:1:exon

YER112W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SDB23
alternative label: USS1
gene: LSM4
locus tag: YER112W
gene synonym: SDB23; USS1
product: U6 snRNA complex subunit LSM4
transcript id: NM_001179002.3
SIO_010081: YER112W
subclass of: SO_0000673
so part of: YER112W
location: <387232..>387795
location: region:387232-387795:1
so has part: feature:387232-387795:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387232-387795:1:exon

YER112W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SDB23
alternative label: USS1
gene: LSM4
locus tag: YER112W
gene synonym: SDB23; USS1
experiment: EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:10369684]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]
experiment: EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:17984320|PMID:18981231]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]
experiment: EXISTENCE:mutant phenotype:GO:0017070 U6 snRNA binding [PMID:10369684]
experiment: EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:17984320|PMID:18981231]
experiment: EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]
note: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
codon start: 1
product: U6 snRNA complex subunit LSM4
translation: MLPLYLLTNAKGQQMQIELKNGEIIQGILTNVDNWMNLTLSNVTEYSEESAINSEDNAESSKAVKLNEIYIRGTFIKFIKLQDNIIDKVKQQINSNNNSNSNGPGHKRYYNNRDSNNNRGNYNRRNNNNGNSNRRPYSQNRQYNNSNSSNINNSINSINSNNQNMNNGLGGSVQHHFNSSSPQKVEF
SIO_010081: YER112W
subclass of: SO_0000673
so part of: YER112W
location: 387232..387795
location: region:387232-387795:1
so has part: feature:387232-387795:1:exon

NP_011037.3
type: Protein
SIO_000068: ncbiprotein

S000000914
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387232-387795:1:exon

YER113C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TMN3
locus tag: YER113C
so part of: sequence
location: complement(<387932..>390052)
location: region:387932-390052:-1
so has part: feature:387932-390052:-1:exon
subclass of: SO_0000010

856849
type: Gene
SIO_000068: ncbigene

position:387932:-1
position: 387932
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:390052:-1
position: 390052
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:387932-390052:-1:exon

YER113C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TMN3
locus tag: YER113C
product: Tmn3p
transcript id: NM_001179003.3
SIO_010081: YER113C
subclass of: SO_0000673
so part of: YER113C
location: complement(<387932..>390052)
location: region:387932-390052:-1
so has part: feature:387932-390052:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:387932-390052:-1:exon

YER113C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TMN3
locus tag: YER113C
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0006878 cellular copper ion homeostasis [PMID:20681974]
experiment: EXISTENCE:genetic interaction:GO:0007034 vacuolar transport [PMID:20526336]
experiment: EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:18178563]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18178563]
note: Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
codon start: 1
product: Tmn3p
translation: MRVRPKRSVITLMAIVVVMLILRNQFYSSRTRGHGQEPVISSSQKNLYDGWITPNFYRKGDPLELIVNKVESDLTQLPYAYYDLPFTCPPTMHKKPLHLSLNEIIRGDRKWESDYKLKFGEDNPCETLCARKTTKEGMQTLDKLVREGYVVQWLIDDELPAATTFISTTDHKKYYASGFPLGFIDPDTDKTYLHNHVMLVIRFHASDNDKNTIVGFEVYPRSVSDYHCPGASKNYEQYEIVIPEDENELTYLPFTYSVYWREEFEVDWNHRWDYFLNAGELSDEQSIQFHWMSLANSVGIVLSISFITLIIYVRVMYTDKSNSKSPKYMINIEGIETEDDLDDDKYGKYSVYTVAKDWIQNGRPNLFGLKVLILLVSFGVQFLFTIIGSLTISCSMNKLHNVRNSVLTMAILFFVLGAFMASFVGTRLSMVTKTKRTKANYLDDNRYLKDYKKFSPIFTILCGSSLPGIVMVSTFLLNSIVWAHDSTSALPFKTIVFFMSIYFIVCIPLSLFGGIVANNIPLPQYWLSGITKDESNSDGNGLFVPKSRAKFNPLVYCGIYLCGIFPLLVIYVEMQYVYKSLWLEKTTFYYFYGFLFLSIILLCVLTMEISIIGSYLLMRFCFEDKVVRNNWRWKCFEMGFSGGVYMELYSLYYIFAVLNIHGFSSILISICYSLIFNVMCSLGLGALSYLTASWFINKIYHQKVNL
SIO_010081: YER113C
subclass of: SO_0000673
so part of: YER113C
location: complement(387932..390052)
location: region:387932-390052:-1
so has part: feature:387932-390052:-1:exon

NP_011038.3
type: Protein
SIO_000068: ncbiprotein

S000000915
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:387932-390052:-1:exon

YER114C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BEB1
gene: BOI2
locus tag: YER114C
gene synonym: BEB1
so part of: sequence
location: complement(<390590..>393712)
location: region:390590-393712:-1
so has part: feature:390590-393712:-1:exon
subclass of: SO_0000010

856850
type: Gene
SIO_000068: ncbigene

position:390590:-1
position: 390590
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:393712:-1
position: 393712
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:390590-393712:-1:exon

YER114C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BEB1
gene: BOI2
locus tag: YER114C
gene synonym: BEB1
product: Boi2p
transcript id: NM_001179004.1
SIO_010081: YER114C
subclass of: SO_0000673
so part of: YER114C
location: complement(<390590..>393712)
location: region:390590-393712:-1
so has part: feature:390590-393712:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:390590-393712:-1:exon

YER114C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BEB1
gene: BOI2
locus tag: YER114C
gene synonym: BEB1
experiment: EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:28751498]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12097146]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12097146]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:12097146]
experiment: EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16615892]
experiment: EXISTENCE:genetic interaction:GO:0007015 actin filament organization [PMID:31964708]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:17417630]
experiment: EXISTENCE:mutant phenotype:GO:0099500 vesicle fusion to plasma membrane [PMID:28751498]
note: Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
codon start: 1
product: Boi2p
translation: MSNDREVPTLSQLNTTVSRDKDVSDTLSPDFDSKGSATGRDGGNFPMYIAINEYFKRMEDELDMKPGDKIKVITDDEEYKDGWYFGRNLRTNEEGLYPVVFTQKITVEKAPTLMRAKSTKRIYSPLTNEDPLLSSTFISENDSNSELPTPQPIETAASISRTANGKIERNLSLKNTMSDIDNALLEFKDDSIGPPDRFINSGRDEEHSITHETILSATDGLDVVESNSKPTTSSSTGFLNGDLENQATLINGIDTTKLNPVEAEFWSPEEITAYFIMEGYDVQSASRFQKHKISGKILLELELVHLKELDINSFGTRFEIFKEIEKIKEAIRTNGRSLNRASKTNNANIYNQLMPPANVDQRASYRGHVRKTSQSLEDLPSQQNFIPTPRNTRNSSASKHRPKSLVFDSQEANANIAPDVQIPQVVEEMAGNENLFVSPRRAPKPPSYPSPAQPPKSPLLNNTRTSPSPAQLYSWQSPTLSFSGPKRTSYIDQYSSSDSNFNSRSALPKNNQGGGKALSPIPSPTRNSVRNEDSEGKLTSSSKRNSVPYYGYAPESSSDRKSSCSSHEEEQFQETMNTFERPTSSIYADGSTIASISNDKLAHEKEGKKKPTRHSSSLSSKSKSDSRRNSSLKRSSSASRTSSFKKSSFMLSPFRQQFTDNAARSSSPEENPITSMPSEKNSSPIVDKKSSKKSRSKRRSVSAKEAEIFTETVKDDKNKRSASEAIKGETLKGKSLRQMTARPVAKKKQTSAFIEGLRSISVKEAMKDADFSGWMSKKGSGAMSTWKTRFFTLHGTRLSYFSSTTDTRERGLIDITAHRVVPAKEDDKLVSLYAASTGKGRYCFKLLPPQPGSKKGLTFTQPRTHYFAVDNKEEMRGWMAALIKTTIDIDTSVPIISSYTTPTVSLSKAQEMLAEAREETKLREQQMLENEEDEDQFLWDQQQLQQQQHDNNQGQADRTISASTQRTSDEDNTISTPNLSSANNTTIGSNGFSSPFLLASGLLSPGVARNSSMRGTEKKGKFSTEEDYFGDNSKHKTDKI
SIO_010081: YER114C
subclass of: SO_0000673
so part of: YER114C
location: complement(390590..393712)
location: region:390590-393712:-1
so has part: feature:390590-393712:-1:exon

NP_011039.1
type: Protein
SIO_000068: ncbiprotein

S000000916
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:390590-393712:-1:exon

YER115C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPR6
locus tag: YER115C
so part of: sequence
location: complement(<394292..>394867)
location: region:394292-394867:-1
so has part: feature:394292-394867:-1:exon
subclass of: SO_0000010

856851
type: Gene
SIO_000068: ncbigene

position:394292:-1
position: 394292
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:394867:-1
position: 394867
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:394292-394867:-1:exon

YER115C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPR6
locus tag: YER115C
product: Spr6p
transcript id: NM_001179005.1
SIO_010081: YER115C
subclass of: SO_0000673
so part of: YER115C
location: complement(<394292..>394867)
location: region:394292-394867:-1
so has part: feature:394292-394867:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:394292-394867:-1:exon

YER115C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPR6
locus tag: YER115C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]
experiment: EXISTENCE:expression pattern:GO:0030437 ascospore formation [PMID:2253272]
note: hypothetical protein; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
codon start: 1
product: Spr6p
translation: MAVSNIWQSYSSSNLHWIYPLYTNNCSQNVKSSFTAEILLKRRCNDIQDILNDRMIELLLQGACDPNKQQNYLQGMSPSRKKKTHVKKFLKKQKKSRKPITLEHGCLSGPVTLRFGNFAGIRDLRGTRCPLHGIKHGVHPKPGERCACQQATLFPSPLARFSCDQSAVLGCAASSTRVYDSIADEFSSLYF
SIO_010081: YER115C
subclass of: SO_0000673
so part of: YER115C
location: complement(394292..394867)
location: region:394292-394867:-1
so has part: feature:394292-394867:-1:exon

NP_011040.1
type: Protein
SIO_000068: ncbiprotein

S000000917
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:394292-394867:-1:exon

YER116C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLX8
locus tag: YER116C
so part of: sequence
location: complement(<395348..>396172)
location: region:395348-396172:-1
so has part: feature:395348-396172:-1:exon
subclass of: SO_0000010

856852
type: Gene
SIO_000068: ncbigene

position:395348:-1
position: 395348
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:396172:-1
position: 396172
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:395348-396172:-1:exon

YER116C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLX8
locus tag: YER116C
product: SUMO-targeted ubiquitin ligase complex subunit SLX8
transcript id: NM_001179006.3
SIO_010081: YER116C
subclass of: SO_0000673
so part of: YER116C
location: complement(<395348..>396172)
location: region:395348-396172:-1
so has part: feature:395348-396172:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:395348-396172:-1:exon

YER116C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLX8
locus tag: YER116C
EC number: 2.3.2.27
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:26906737]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:17728242|PMID:17848550|PMID:18032921|PMID:26906737]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19270524|PMID:26906737|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:17728242|PMID:17848550|PMID:18032921|PMID:26906737]
experiment: EXISTENCE:direct assay:GO:0033768 SUMO-targeted ubiquitin ligase complex [PMID:17848550]
experiment: EXISTENCE:genetic interaction:GO:0006974 cellular response to DNA damage stimulus [PMID:11139495]
experiment: EXISTENCE:genetic interaction:GO:0016567 protein ubiquitination [PMID:26906737]
experiment: EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:16387868]
experiment: EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16428246]
experiment: EXISTENCE:mutant phenotype:GO:0006974 cellular response to DNA damage stimulus [PMID:11139495|PMID:16325482]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:26906737]
experiment: EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:16387868]
note: Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF4
codon start: 1
product: SUMO-targeted ubiquitin ligase complex subunit SLX8
translation: MARRPDNQNPEGENLRIKRVRLESVRQNDEEEENEVSRTQNIVTDNRHDSPEAVVEIIGERALENTSEEDGDDDLSLFRALEEDPGSDHNTSNNDSGNHDRETMHTEEPEASSGNNITLTNNVEELHTMDVLSQTANTPSASPMLDAAPPTTKPGTNSKEQTVDLTADAIDLDAEEQQVLQISDDDFQEETKEAPKEYGAAKDYRCPICFEPPETALMTLCGHVFCCPCLFQMVNSSRTCRQFGHCALCRSKVYLKDVRLIILRKKQVKKKVKS
SIO_010081: YER116C
subclass of: SO_0000673
so part of: YER116C
location: complement(395348..396172)
location: region:395348-396172:-1
so has part: feature:395348-396172:-1:exon

NP_011041.3
type: Protein
SIO_000068: ncbiprotein

S000000918
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:395348-396172:-1:exon

YER117W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPL23B
locus tag: YER117W
so part of: sequence
location: <396769..>397653
location: region:396769-397653:1
so has part: feature:396769-397653:1:exon
subclass of: SO_0000010

856853
type: Gene
SIO_000068: ncbigene

position:396769:1
position: 396769
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:397653:1
position: 397653
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:396769-397653:1:exon

YER117W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPL23B
locus tag: YER117W
product: ribosomal 60S subunit protein L23B
transcript id: NM_001179007.3
SIO_010081: YER117W
subclass of: SO_0000673
so part of: YER117W
location: join(<396769..396810,397282..>397653)
location: region:396769-397653:1
so has part: feature:396769-396810:1:exon
so has part: feature:397282-397653:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:396769-396810:1:exon

position:396810:1
position: 396810
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:397282-397653:1:exon

position:397282:1
position: 397282
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YER117W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPL23B
locus tag: YER117W
experiment: EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]
experiment: EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]
note: Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication
codon start: 1
product: ribosomal 60S subunit protein L23B
translation: MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV
SIO_010081: YER117W
subclass of: SO_0000673
so part of: YER117W
location: join(396769..396810,397282..397653)
location: region:396769-397653:1
so has part: feature:396769-396810:1:exon
so has part: feature:397282-397653:1:exon

NP_011042.3
type: Protein
SIO_000068: ncbiprotein

S000000919
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:396769-396810:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:397282-397653:1:exon

YER118C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SSU81
gene: SHO1
locus tag: YER118C
gene synonym: SSU81
so part of: sequence
location: complement(<397952..>399055)
location: region:397952-399055:-1
so has part: feature:397952-399055:-1:exon
subclass of: SO_0000010

856854
type: Gene
SIO_000068: ncbigene

position:397952:-1
position: 397952
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:399055:-1
position: 399055
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:397952-399055:-1:exon

YER118C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SSU81
gene: SHO1
locus tag: YER118C
gene synonym: SSU81
product: osmosensor SHO1
transcript id: NM_001179008.1
SIO_010081: YER118C
subclass of: SO_0000673
so part of: YER118C
location: complement(<397952..>399055)
location: region:397952-399055:-1
so has part: feature:397952-399055:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:397952-399055:-1:exon

YER118C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SSU81
gene: SHO1
locus tag: YER118C
gene synonym: SSU81
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10980703]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:10980703]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10980703|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12374868]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:7624781]
experiment: EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:19439450]
experiment: EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:9744864|PMID:18591427]
experiment: EXISTENCE:mutant phenotype:GO:0005078 MAP-kinase scaffold activity [PMID:15200958]
experiment: EXISTENCE:physical interaction:GO:0005034 osmosensor activity [PMID:7624781]
experiment: EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:15200958|PMID:16778768]
experiment: EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:7624781]
experiment: EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]
note: Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
codon start: 1
product: osmosensor SHO1
translation: MSISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSWVIAIGGSISSASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNLVYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHRARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPNTSEAVNLHLNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMHR
SIO_010081: YER118C
subclass of: SO_0000673
so part of: YER118C
location: complement(397952..399055)
location: region:397952-399055:-1
so has part: feature:397952-399055:-1:exon

NP_011043.1
type: Protein
SIO_000068: ncbiprotein

S000000920
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:397952-399055:-1:exon

YER119C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: AVT6
locus tag: YER119C
so part of: sequence
location: complement(<399496..>400842)
location: region:399496-400842:-1
so has part: feature:399496-400842:-1:exon
subclass of: SO_0000010

856855
type: Gene
SIO_000068: ncbigene

position:399496:-1
position: 399496
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:400842:-1
position: 400842
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:399496-400842:-1:exon

YER119C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: AVT6
locus tag: YER119C
product: aspartate/glutamate transporter
transcript id: NM_001179009.1
SIO_010081: YER119C
subclass of: SO_0000673
so part of: YER119C
location: complement(<399496..>400842)
location: region:399496-400842:-1
so has part: feature:399496-400842:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:399496-400842:-1:exon

YER119C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: AVT6
locus tag: YER119C
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20118605|PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0005313 L-glutamate transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0015183 L-aspartate transmembrane transporter activity [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]
experiment: EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11274162]
note: Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication
codon start: 1
product: aspartate/glutamate transporter
translation: MVASIRSGVLTLLHTACGAGILAMPYAFKPFGLIPGVIMIVLCGACAMQSLFIQARVAKYVPQGRASFSALTRLINPNLGIVFDLAIAIKCFGVGVSYMIVVGDLMPQIMSVWTRNAWLLNRNVQISLIMLFFVAPLSFLKKLNSLRYASMVAISSVAYLCVLVLLHYVAPSDEILRLKGRISYLLPPQSHDLNVLNTLPIFVFAYTCHHNMFSIINEQRSSRFEHVMKIPLIAISLALILYIAIGCAGYLTFGDNIIGNIIMLYPQAVSSTIGRIAIVLLVMLAFPLQCHPARASIHQILQHFAEENVSISATSADEPTVATESSPLIRDSSLDLNEVIEEESIYQPKETPLRGKSFIVITCSILVASYLVAISVSSLARVLAIVGATGSTSISFILPGLFGYKLIGTEHKTAVPLTTKIFKYTGLLLFIWGLIIMITCLTAALKLN
SIO_010081: YER119C
subclass of: SO_0000673
so part of: YER119C
location: complement(399496..400842)
location: region:399496-400842:-1
so has part: feature:399496-400842:-1:exon

NP_011044.1
type: Protein
SIO_000068: ncbiprotein

S000000921
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:399496-400842:-1:exon

YER120W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCS2
locus tag: YER120W
so part of: sequence
location: <401135..>401869
location: region:401135-401869:1
so has part: feature:401135-401869:1:exon
subclass of: SO_0000010

856856
type: Gene
SIO_000068: ncbigene

position:401135:1
position: 401135
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:401869:1
position: 401869
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:401135-401869:1:exon

YER120W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCS2
locus tag: YER120W
product: phosphatidylinositol-binding protein SCS2
transcript id: NM_001179010.3
SIO_010081: YER120W
subclass of: SO_0000673
so part of: YER120W
location: <401135..>401869
location: region:401135-401869:1
so has part: feature:401135-401869:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:401135-401869:1:exon

YER120W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCS2
locus tag: YER120W
experiment: EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12727870|PMID:25420878]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12727870|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9537365]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25420878]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17984322]
experiment: EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:9537365]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:17963691]
experiment: EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]
experiment: EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:25420878]
experiment: EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:8537323]
experiment: EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:11333225|PMID:12399377]
experiment: EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:17984322]
experiment: EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]
experiment: EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]
experiment: EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]
experiment: EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:12761300|PMID:9537365]
experiment: EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11333225]
experiment: EXISTENCE:mutant phenotype:GO:0032377 regulation of intracellular lipid transport [PMID:12727870]
experiment: EXISTENCE:mutant phenotype:GO:0033149 FFAT motif binding [PMID:12727870]
experiment: EXISTENCE:mutant phenotype:GO:0042308 negative regulation of protein import into nucleus [PMID:12727870]
experiment: EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:17984322]
experiment: EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]
experiment: EXISTENCE:physical interaction:GO:0033149 FFAT motif binding [PMID:12727870]
experiment: EXISTENCE:physical interaction:GO:0042308 negative regulation of protein import into nucleus [PMID:12727870]
note: Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
codon start: 1
product: phosphatidylinositol-binding protein SCS2
translation: MSAVEISPDVLVYKSPLTEQSTEYASISNNSDQTIAFKVKTTAPKFYCVRPNAAVVAPGETIQVQVIFLGLTEEPAADFKCRDKFLVITLPSPYDLNGKAVADVWSDLEAEFKQQAISKKIKVKYLISPDVHPAQNQNIQENKETVEPVVQDSEPKEVPAVVNEKEVPAEPETQPPVQVKKEEVPPVVQKTVPHENEKQTSNSTPAPQNQIKEAATVPAENESSSMGIFILVALLILVLGWFYR
SIO_010081: YER120W
subclass of: SO_0000673
so part of: YER120W
location: 401135..401869
location: region:401135-401869:1
so has part: feature:401135-401869:1:exon

NP_011046.3
type: Protein
SIO_000068: ncbiprotein

S000000922
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:401135-401869:1:exon

YER121W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER121W
so part of: sequence
location: <402375..>402719
location: region:402375-402719:1
so has part: feature:402375-402719:1:exon
subclass of: SO_0000010

856858
type: Gene
SIO_000068: ncbigene

position:402375:1
position: 402375
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:402719:1
position: 402719
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402375-402719:1:exon

YER121W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER121W
product: uncharacterized protein
transcript id: NM_001179011.3
SIO_010081: YER121W
subclass of: SO_0000673
so part of: YER121W
location: <402375..>402719
location: region:402375-402719:1
so has part: feature:402375-402719:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402375-402719:1:exon

YER121W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER121W
note: hypothetical protein; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
codon start: 1
product: uncharacterized protein
translation: MGLSRWHDKNSRPAEEKSEEMQQDAHYYALAASDSLNASVSNEYGNQVMNSFWKVGIDSPYVDDEAIRNRDVENNLPSLKQSVYNANEPNATSSAFSTASYAHETFDFRNLKLR
SIO_010081: YER121W
subclass of: SO_0000673
so part of: YER121W
location: 402375..402719
location: region:402375-402719:1
so has part: feature:402375-402719:1:exon

NP_011047.3
type: Protein
SIO_000068: ncbiprotein

S000000923
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402375-402719:1:exon

YER122C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GLO3
locus tag: YER122C
so part of: sequence
location: complement(<402871..>404352)
location: region:402871-404352:-1
so has part: feature:402871-404352:-1:exon
subclass of: SO_0000010

856859
type: Gene
SIO_000068: ncbigene

position:402871:-1
position: 402871
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:404352:-1
position: 404352
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:402871-404352:-1:exon

YER122C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GLO3
locus tag: YER122C
product: ADP-ribosylation factor GTPase-activating protein
transcript id: NM_001179012.1
SIO_010081: YER122C
subclass of: SO_0000673
so part of: YER122C
location: complement(<402871..>404352)
location: region:402871-404352:-1
so has part: feature:402871-404352:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:402871-404352:-1:exon

YER122C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GLO3
locus tag: YER122C
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9927415]
experiment: EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]
experiment: EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:15254269]
experiment: EXISTENCE:direct assay:GO:0048205 COPI coating of Golgi vesicle [PMID:15254269]
experiment: EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9927415]
experiment: EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]
experiment: EXISTENCE:mutant phenotype:GO:0048205 COPI coating of Golgi vesicle [PMID:15254269]
experiment: EXISTENCE:physical interaction:GO:0030126 COPI vesicle coat [PMID:15254269]
note: ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p
codon start: 1
product: ADP-ribosylation factor GTPase-activating protein
translation: MSNDEGETFATEQTTQQVFQKLGSNMENRVCFDCGNKNPTWTSVPFGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTINNLRRFKLGGNHKARDFFLKNNGKQLLNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELVLNGQDSSDSPLDTDSDASRSTSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTPKTTVTKTRSSILTASRKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDLFDQFKKEAQQEKEDEFTNSSSSTKIRQNDYDSQFMNNSKGNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLTPKFAKLGFGMTMNDANDLAKQQKESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSFDEAANREAHDKLKTFDNATSISSSSYFGEDKEVDEFGNPINSSGSGAGNFDGRNSNNGFIDFNASADDELQMLRDVVEQGAEKLGSYLRDYLRK
SIO_010081: YER122C
subclass of: SO_0000673
so part of: YER122C
location: complement(402871..404352)
location: region:402871-404352:-1
so has part: feature:402871-404352:-1:exon

NP_011048.1
type: Protein
SIO_000068: ncbiprotein

S000000924
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:402871-404352:-1:exon

YER123W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CKI3
gene: YCK3
locus tag: YER123W
gene synonym: CKI3
so part of: sequence
location: <404813..>406387
location: region:404813-406387:1
so has part: feature:404813-406387:1:exon
subclass of: SO_0000010

856860
type: Gene
SIO_000068: ncbigene

position:404813:1
position: 404813
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:406387:1
position: 406387
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:404813-406387:1:exon

YER123W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CKI3
gene: YCK3
locus tag: YER123W
gene synonym: CKI3
product: casein kinase YCK3
transcript id: NM_001179013.1
SIO_010081: YER123W
subclass of: SO_0000673
so part of: YER123W
location: <404813..>406387
location: region:404813-406387:1
so has part: feature:404813-406387:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:404813-406387:1:exon

YER123W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CKI3
gene: YCK3
locus tag: YER123W
gene synonym: CKI3
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16301533]
experiment: EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14668479|PMID:24390141|PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8816449]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8816449]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:19116312]
note: Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; targeted to vacuole via AP-3 pathway; regulates vesicle fusion in AP-3 pathway
codon start: 1
product: casein kinase YCK3
translation: MSQRSSQHIVGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRDEFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQRISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSINTHFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIGMTKQKLNPDDLLLNNAIPYQFATYLKYARSLKFDEDPDYDYLISLMDDALRLNDLKDDGHYDWMDLNGGKGWNIKINRRANLHGYGNPNPRVNGNTARNNVNTNSKTRNTTPVATPKQQAQNSYNKDNSKSRISSNPQSFTKQQHVLKKIEPNSKYIPETHSNLQRPIKSQSQTYDSISHTQNSPFVPYSSSKANPKRSNNEHNLPNHYTNLANKNINYQSQRNYEQENDAYSDDENDTFCSKIYKYCCCCFCCC
SIO_010081: YER123W
subclass of: SO_0000673
so part of: YER123W
location: 404813..406387
location: region:404813-406387:1
so has part: feature:404813-406387:1:exon

NP_011049.2
type: Protein
SIO_000068: ncbiprotein

S000000925
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:404813-406387:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS517; Autonomously Replicating Sequence
so part of: sequence
location: 406752..406953
location: region:406752-406953:1
so has part: feature:406752-406953:1:region

S000077389
type: SGD
SIO_000068: sgd

position:406752:1
position: 406752
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:406953:1
position: 406953
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:406752-406953:1:region

YER124C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DSE1
locus tag: YER124C
so part of: sequence
location: complement(<407342..>409063)
location: region:407342-409063:-1
so has part: feature:407342-409063:-1:exon
subclass of: SO_0000010

856861
type: Gene
SIO_000068: ncbigene

position:407342:-1
position: 407342
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:409063:-1
position: 409063
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:407342-409063:-1:exon

YER124C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DSE1
locus tag: YER124C
product: Dse1p
transcript id: NM_001179014.3
SIO_010081: YER124C
subclass of: SO_0000673
so part of: YER124C
location: complement(<407342..>409063)
location: region:407342-409063:-1
so has part: feature:407342-409063:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:407342-409063:-1:exon

YER124C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DSE1
locus tag: YER124C
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0031683 G-protein beta/gamma-subunit complex binding [PMID:19820940]
experiment: EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11309124]
experiment: EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:19820940]
experiment: EXISTENCE:mutant phenotype:GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:19820940]
note: Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress
codon start: 1
product: Dse1p
translation: MQDTKYYEPTNIFRQPAINIKKRSDKKRILQSMMTLSTYKKTWQNNTSKMNSPILRKASDNFNDYYTTKKLKSDYWKLYGVDESELSIPSDMSIVDNILLVSTMNEKDNLKLFEISAEKKLKELQTITVPGKPITCICLLPMVDFPPQIFPSSQINPNHNQLILTGHQDGIVNLIATSTYKGCAKIIKRFNHNKFLKSTVSTSIPILEITPKTAPILKVSPWNKTGFVSLLNDSLFIYDLKSNLDCIKTPIFLQSYPGINSFAVNEFHDPFLLALVGSKFGPNGISLLDLRTNLYIPDILDNSISAGCGKDHLQRKNTSLDCVWISNHHVAQSLNDKIQIWDIQSCDGKPVCELYAKKGYIESLKFNENTGALYSSDDQGFVICWDLQNLQNMKYGELVHGFNSISLDSESELLLTKQVFQCGNIIVSGMSDKNICLKSNDTKANGKGCGFLFLDMANDGSLVTLDNFCELGLHQICQVQFNVDTGKIIDGNGTGKSGISDSSMLSLSNESDHSMTETSDDMFSNSGNWDCSSANTVSEGRLNDDQEDIVFTKRMYSVNDVHLSGSTIDTTVV
SIO_010081: YER124C
subclass of: SO_0000673
so part of: YER124C
location: complement(407342..409063)
location: region:407342-409063:-1
so has part: feature:407342-409063:-1:exon

NP_011050.3
type: Protein
SIO_000068: ncbiprotein

S000000926
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:407342-409063:-1:exon

YER125W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HPG1
alternative label: MDP1
alternative label: MUT2
alternative label: NPI1
alternative label: SMM1
alternative label: UBY1
gene: RSP5
locus tag: YER125W
gene synonym: HPG1; MDP1; MUT2; NPI1; SMM1; UBY1
so part of: sequence
location: <410189..>412618
location: region:410189-412618:1
so has part: feature:410189-412618:1:exon
subclass of: SO_0000010

856862
type: Gene
SIO_000068: ncbigene

position:410189:1
position: 410189
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:412618:1
position: 412618
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:410189-412618:1:exon

YER125W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HPG1
alternative label: MDP1
alternative label: MUT2
alternative label: NPI1
alternative label: SMM1
alternative label: UBY1
gene: RSP5
locus tag: YER125W
gene synonym: HPG1; MDP1; MUT2; NPI1; SMM1; UBY1
product: NEDD4 family E3 ubiquitin-protein ligase
transcript id: NM_001179015.3
SIO_010081: YER125W
subclass of: SO_0000673
so part of: YER125W
location: <410189..>412618
location: region:410189-412618:1
so has part: feature:410189-412618:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:410189-412618:1:exon

YER125W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HPG1
alternative label: MDP1
alternative label: MUT2
alternative label: NPI1
alternative label: SMM1
alternative label: UBY1
gene: RSP5
locus tag: YER125W
gene synonym: HPG1; MDP1; MUT2; NPI1; SMM1; UBY1
EC number: 2.3.2.26
experiment: EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:9108033]
experiment: EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:21685393|PMID:23443663|PMID:27694912|PMID:9108033]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14608372]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14657247|PMID:15078904]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]
experiment: EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14657247]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:14608372]
experiment: EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:19176477|PMID:21685393]
experiment: EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:30361468]
experiment: EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:14657247]
experiment: EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19153599]
experiment: EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:23443663]
experiment: EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:19153599]
experiment: EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:15078904]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:19252184]
experiment: EXISTENCE:genetic interaction:GO:0006513 protein monoubiquitination [PMID:14761940|PMID:19176477]
experiment: EXISTENCE:genetic interaction:GO:0006808 regulation of nitrogen utilization [PMID:15247235]
experiment: EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:10366593]
experiment: EXISTENCE:genetic interaction:GO:0010794 regulation of dolichol biosynthetic process [PMID:18771750]
experiment: EXISTENCE:genetic interaction:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:18771750]
experiment: EXISTENCE:genetic interaction:GO:0019220 regulation of phosphate metabolic process [PMID:18165238]
experiment: EXISTENCE:genetic interaction:GO:0032443 regulation of ergosterol biosynthetic process [PMID:18771750]
experiment: EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:15855235]
experiment: EXISTENCE:genetic interaction:GO:0034517 ribophagy [PMID:18670191]
experiment: EXISTENCE:genetic interaction:GO:0051865 protein autoubiquitination [PMID:24069405]
experiment: EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:9108033|PMID:32800549]
experiment: EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:21685393|PMID:27694912|PMID:9108033]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:12399376]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756|PMID:9614172]
experiment: EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:14761940|PMID:19176477|PMID:21685393|PMID:32800549]
experiment: EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10366593]
experiment: EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:12163175]
experiment: EXISTENCE:mutant phenotype:GO:0010793 regulation of mRNA export from nucleus [PMID:14608372]
experiment: EXISTENCE:mutant phenotype:GO:0010794 regulation of dolichol biosynthetic process [PMID:18771750]
experiment: EXISTENCE:mutant phenotype:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:18771750]
experiment: EXISTENCE:mutant phenotype:GO:0010796 regulation of multivesicular body size [PMID:17182850]
experiment: EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]
experiment: EXISTENCE:mutant phenotype:GO:0031384 regulation of initiation of mating projection growth [PMID:21685393]
experiment: EXISTENCE:mutant phenotype:GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [PMID:24962567]
experiment: EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:18771750]
experiment: EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17182849]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:12867034]
experiment: EXISTENCE:mutant phenotype:GO:0034644 cellular response to UV [PMID:10490634]
experiment: EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:17344478]
experiment: EXISTENCE:mutant phenotype:GO:0045723 positive regulation of fatty acid biosynthetic process [PMID:11007476]
experiment: EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:12654912]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11007476]
experiment: EXISTENCE:mutant phenotype:GO:0048260 positive regulation of receptor-mediated endocytosis [PMID:11179425]
experiment: EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:17344478|PMID:31658248|PMID:32800549]
experiment: EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]
experiment: EXISTENCE:mutant phenotype:GO:2000203 regulation of ribosomal large subunit export from nucleus [PMID:14608372]
experiment: EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:14608372]
experiment: EXISTENCE:mutant phenotype:GO:2000235 regulation of tRNA processing [PMID:14608372]
experiment: EXISTENCE:mutant phenotype:GO:2000238 regulation of tRNA export from nucleus [PMID:14608372]
experiment: EXISTENCE:physical interaction:GO:0000151 ubiquitin ligase complex [PMID:9931424]
experiment: EXISTENCE:physical interaction:GO:0009410 response to xenobiotic stimulus [PMID:12163175]
experiment: EXISTENCE:physical interaction:GO:0010793 regulation of mRNA export from nucleus [PMID:15713680]
experiment: EXISTENCE:physical interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17182849]
experiment: EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:12867034]
experiment: EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15713680]
note: NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome
codon start: 1
product: NEDD4 family E3 ubiquitin-protein ligase
translation: MPSSISVKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKKTLNPYWNETFKFDDINENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTATSSGRPREETITRDLKKSNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTTRTNGHSTSSTRNHSTSHPSRGTAQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELERRQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQDMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE

NP_011051.3
type: Protein
SIO_000068: ncbiprotein

S000000927
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:410189-412618:1:exon

YER126C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: NSA2
locus tag: YER126C
so part of: sequence
location: complement(<413394..>414179)
location: region:413394-414179:-1
so has part: feature:413394-414179:-1:exon
subclass of: SO_0000010

856863
type: Gene
SIO_000068: ncbigene

position:413394:-1
position: 413394
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:414179:-1
position: 414179
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:413394-414179:-1:exon

YER126C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: NSA2
locus tag: YER126C
product: rRNA-processing protein NSA2
transcript id: NM_001179016.1
SIO_010081: YER126C
subclass of: SO_0000673
so part of: YER126C
location: complement(<413394..>414179)
location: region:413394-414179:-1
so has part: feature:413394-414179:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:413394-414179:-1:exon

YER126C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: NSA2
locus tag: YER126C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]
experiment: EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:16861225|PMID:11583614|PMID:17443350]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]
experiment: EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]
experiment: EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]
note: Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2
codon start: 1
product: rRNA-processing protein NSA2
translation: MPQNDYIERHIKQHGKRLDHEERKRKREARESHKISERAQKLTGWKGKQFAKKRYAEKVSMRKKIKAHEQSKVKGSSKPLDTDGDALPTYLLDREQNNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEEMFKVIKTGKSRSKSWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTAGGKVVWGKYAQVTNEPDRDGCVNAVLLV
SIO_010081: YER126C
subclass of: SO_0000673
so part of: YER126C
location: complement(413394..414179)
location: region:413394-414179:-1
so has part: feature:413394-414179:-1:exon

NP_011052.1
type: Protein
SIO_000068: ncbiprotein

S000000928
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:413394-414179:-1:exon

YER127W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LCP5
locus tag: YER127W
so part of: sequence
location: <414481..>415554
location: region:414481-415554:1
so has part: feature:414481-415554:1:exon
subclass of: SO_0000010

856864
type: Gene
SIO_000068: ncbigene

position:414481:1
position: 414481
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:415554:1
position: 415554
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:414481-415554:1:exon

YER127W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LCP5
locus tag: YER127W
product: Lcp5p
transcript id: NM_001179017.1
SIO_010081: YER127W
subclass of: SO_0000673
so part of: YER127W
location: <414481..>415554
location: region:414481-415554:1
so has part: feature:414481-415554:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:414481-415554:1:exon

YER127W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LCP5
locus tag: YER127W
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9814757]
experiment: EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9814757]
experiment: EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9814757]
note: Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
codon start: 1
product: Lcp5p
translation: MSELNALLKDINGSLTATSESLERLSGIYSNSATDEIPESNQLHEHLFYDAKKPAEKVSLLSLKNGSMLGYINSLLMLIGNRLDDECKDPSAMDARERSIQHRVVLERGVKPLEKKLAYQLDKLTRAYVKMEKEYKDAEKRALEKSTLVNHSGNDDSEDDESSEDEIAYRPNTSGIINTNKKSSAYRVEETAKQENGEENDDNETGVYKPPKITAVLPPQQTHFEDRFDAREHKDRSNKSRMQAMEEYIRESSDQPDWSASIGADIVNHGRGGIKSLRDTEKERRVTSFEEDNFTRLNITNKAEKRKQKQRERNARMNVIGGEDFGIFSSKRKLEDSTSRRGAKKTRSAWDRAQRRL
SIO_010081: YER127W
subclass of: SO_0000673
so part of: YER127W
location: 414481..415554
location: region:414481-415554:1
so has part: feature:414481-415554:1:exon

NP_011053.1
type: Protein
SIO_000068: ncbiprotein

S000000929
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:414481-415554:1:exon

YER128W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: VFA1
locus tag: YER128W
so part of: sequence
location: <415859..>416470
location: region:415859-416470:1
so has part: feature:415859-416470:1:exon
subclass of: SO_0000010

856865
type: Gene
SIO_000068: ncbigene

position:415859:1
position: 415859
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:416470:1
position: 416470
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:415859-416470:1:exon

YER128W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: VFA1
locus tag: YER128W
product: Vfa1p
transcript id: NM_001179018.3
SIO_010081: YER128W
subclass of: SO_0000673
so part of: YER128W
location: <415859..>416470
location: region:415859-416470:1
so has part: feature:415859-416470:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:415859-416470:1:exon

YER128W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: VFA1
locus tag: YER128W
experiment: EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:24567329]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21777356]
experiment: EXISTENCE:direct assay:GO:0005768 endosome [PMID:21777356]
experiment: EXISTENCE:direct assay:GO:0032781 positive regulation of ATP-dependent activity [PMID:24567329]
experiment: EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:21777356]
note: Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
codon start: 1
product: Vfa1p
translation: MINEYVARKVALKDMQPCAICSKPSTTVLYNASGPDWLYTCEIHLQDNPQFVIPLYSTEYNEAVAQLKLVKGKMDSLTSAQTQLGSWDGWVTKIFSKKEKETNNSKDPDPTTTDSTDTSPQAKNDAEILSETKKQYSKILDKVTELQRKNRKYELAKIMFESRLLRKRTEQVNRERYLKEQENYSNTDPEELLRKHVFPSVPK
SIO_010081: YER128W
subclass of: SO_0000673
so part of: YER128W
location: 415859..416470
location: region:415859-416470:1
so has part: feature:415859-416470:1:exon

NP_011054.3
type: Protein
SIO_000068: ncbiprotein

S000000930
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:415859-416470:1:exon

YER129W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PAK1
gene: SAK1
locus tag: YER129W
gene synonym: PAK1
so part of: sequence
location: <417281..>420709
location: region:417281-420709:1
so has part: feature:417281-420709:1:exon
subclass of: SO_0000010

856866
type: Gene
SIO_000068: ncbigene

position:417281:1
position: 417281
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:420709:1
position: 420709
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:417281-420709:1:exon

YER129W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PAK1
gene: SAK1
locus tag: YER129W
gene synonym: PAK1
product: serine/threonine protein kinase SAK1
transcript id: NM_001179019.3
SIO_010081: YER129W
subclass of: SO_0000673
so part of: YER129W
location: <417281..>420709
location: region:417281-420709:1
so has part: feature:417281-420709:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:417281-420709:1:exon

YER129W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PAK1
gene: SAK1
locus tag: YER129W
gene synonym: PAK1
EC number: 2.7.11.1
experiment: EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]
experiment: EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:12748292|PMID:12847291|PMID:16201971|PMID:27524664]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22289182]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0090329 regulation of DNA-templated DNA replication [PMID:9341678]
experiment: EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:12748292|PMID:16201971]
experiment: EXISTENCE:mutant phenotype:GO:0005979 regulation of glycogen biosynthetic process [PMID:15340085]
experiment: EXISTENCE:mutant phenotype:GO:1900180 regulation of protein localization to nucleus [PMID:15340085]
experiment: EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:19880754]
note: Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication
codon start: 1
product: serine/threonine protein kinase SAK1
translation: MDRSDKKVNVEEVNVPSNLQIELEKSGTSSSVSLRSPTKSSATNLAGMAEGARDNASIASSSVDSLNMLLERQRVRQLNHPQHQQHISSSLAKTPTTTSSFCSSGSSKNKVKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFVSWDFDHVPENDEKLLSSVLEQKLRFQCNQTDQFEPISISKHELKNAVSGVGKKIKESVLKSIPLKDPSDLSNKNYLHPTETTRGRGDANVIVSEGSVLSNIKELSANDGCLNTDSDTNININDDDHYSGDDNDGHLTKRELERELNKFDDKHEAGNMVNLPINSSFASLDSFYIDNFAMARMGMSSPEAGDSVSSVPNLPSAPSSTRLGRSPVFSGVTNQPSPIRPVLPQQKSSFCATGRYDKSHNSLLRNSSSHLTSYNSGRPSSRTGRMNSRNQNLPKIPNSLSKISTTKLTELRVPKDSEIPSPAKNPNADRLRRFPVKKNTKTPAIKDPPRININSSDKSGSKNSPIKSLYQRMKQSKDNSKTFEVRRGNFFSHFNGDDDDSSSQSSVTSSGSESDSELSSTSSSCTSGTQSRNSSNNNAYSETESLPFEFGVDSEDGSGVLLRDLPNEDQIRPFLDIQPCRRMKVKSSLNLEPPSVSSSSSSSSDEDELILNVGTAGHRRRHNSSKLSELSNSPQKGSNNFMYSNGSVHDSETTITPQNMDDLTLHQALSRSQPISKPGPLVLPKRLDQKKATTETSNLTDIVEFNGNNDHRKDKNFDKVLYSRDLLKDALSSTNAGRRRSIPSNKIRGRKDASITMSTNVGNDEHARNTSCHGDKGQENGAIKQRTHERSRSLTVAELNEEKRRSALP
SIO_010081: YER129W
subclass of: SO_0000673
so part of: YER129W
location: 417281..420709
location: region:417281-420709:1
so has part: feature:417281-420709:1:exon

NP_011055.3
type: Protein
SIO_000068: ncbiprotein

S000000931
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:417281-420709:1:exon

YER130C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COM2
locus tag: YER130C
so part of: sequence
location: complement(<421115..>422446)
location: region:421115-422446:-1
so has part: feature:421115-422446:-1:exon
subclass of: SO_0000010

856867
type: Gene
SIO_000068: ncbigene

position:421115:-1
position: 421115
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:422446:-1
position: 422446
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:421115-422446:-1:exon

YER130C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COM2
locus tag: YER130C
product: Com2p
transcript id: NM_001179020.1
SIO_010081: YER130C
subclass of: SO_0000673
so part of: YER130C
location: complement(<421115..>422446)
location: region:421115-422446:-1
so has part: feature:421115-422446:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:421115-422446:-1:exon

YER130C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COM2
locus tag: YER130C
experiment: EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:24236068]
experiment: EXISTENCE:mutant phenotype:GO:0071252 cellular response to sulfur dioxide [PMID:31799324]
experiment: EXISTENCE:mutant phenotype:GO:0080135 regulation of cellular response to stress [PMID:31799324]
note: Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress
codon start: 1
product: Com2p
translation: MSLYPLQRFESNDTVFSYTLNSKTELFNESRNNDKQHFTLQLIPNANANAKEIDNNNVEIINDLTGNTIVDNCVTTATSSNQLERRLSISDYRTENGNYYEYEFFGRRELNEPLFNNDIVENDDDIDLNNESDVLMVSDDELEVNERFSFLKQQPLDGLNRISSTNNLKNLEIHEFIIDPTENIDDELEDSFTTVPQSKKKVRDYFKLNIFGSSSSSNNNSNSLGCEPIQTENSSSQKMFKNRFFRSRKSTLIKSLPLEQENEVLINSGFDVSSNEESDESDHAIINPLKLVGNNKDISTQSIAKTTNPFKSGSDFKMIEPVSKFSNDSRKDLLAAISEPSSSPSPSAPSPSVQSSSSSHGLVVRKKTGSMQKTRGRKPSLIPDASKQFGCEFCDRRFKRQEHLKRHVRSLHMCEKPFTCHICNKNFSRSDNLNQHVKTHASL
SIO_010081: YER130C
subclass of: SO_0000673
so part of: YER130C
location: complement(421115..422446)
location: region:421115-422446:-1
so has part: feature:421115-422446:-1:exon

NP_011056.1
type: Protein
SIO_000068: ncbiprotein

S000000932
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:421115-422446:-1:exon

YER131W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RPS26B
locus tag: YER131W
so part of: sequence
location: <423952..>424311
location: region:423952-424311:1
so has part: feature:423952-424311:1:exon
subclass of: SO_0000010

856868
type: Gene
SIO_000068: ncbigene

position:423952:1
position: 423952
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:424311:1
position: 424311
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:423952-424311:1:exon

YER131W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RPS26B
locus tag: YER131W
product: ribosomal 40S subunit protein S26B
transcript id: NM_001179021.1
SIO_010081: YER131W
subclass of: SO_0000673
so part of: YER131W
location: <423952..>424311
location: region:423952-424311:1
so has part: feature:423952-424311:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:423952-424311:1:exon

YER131W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RPS26B
locus tag: YER131W
experiment: EXISTENCE:genetic interaction:GO:0006407 rRNA export from nucleus [PMID:16246728]
experiment: EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25144938]
experiment: EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:27303706]
experiment: EXISTENCE:physical interaction:GO:0030686 90S preribosome [PMID:25144938]
note: Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia
codon start: 1
product: ribosomal 40S subunit protein S26B
translation: MPKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIVEAAAVRDLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPPQRPRFNRDNKVSPAAAAKKAL
SIO_010081: YER131W
subclass of: SO_0000673
so part of: YER131W
location: 423952..424311
location: region:423952-424311:1
so has part: feature:423952-424311:1:exon

NP_011057.1
type: Protein
SIO_000068: ncbiprotein

S000000933
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:423952-424311:1:exon

YNCE0019W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR4
locus tag: YNCE0019W
so part of: sequence
location: 424698..424883
location: region:424698-424883:1
so has part: feature:424698-424883:1:exon
subclass of: SO_0000578

9164882
type: Gene
SIO_000068: ncbigene

position:424698:1
position: 424698
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:424883:1
position: 424883
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:424698-424883:1:exon

YNCE0019W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR4
locus tag: YNCE0019W
product: SNR4
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:3327689]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:3327689]
experiment: EXISTENCE:direct assay:GO:0031428 box C/D RNP complex [PMID:10094313]
experiment: EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:28542199]
experiment: EXISTENCE:mutant phenotype:GO:1990882 rRNA acetylation [PMID:28542199]
experiment: EXISTENCE:physical interaction:GO:0031428 box C/D RNP complex [PMID:10733567|PMID:11081632]
experiment: EXISTENCE:physical interaction:GO:0042134 rRNA primary transcript binding [PMID:3327689]
note: C/D box small nucleolar RNA (snoRNA); acts as antisense guide to target RNA base acetylation by Kre33p to cytosine 1280 in 18S rRNA (responsible for ac4C 1280); establishes extended bipartite complementarity around the cytosines targeted for acetylation, similar to pseudouridylation pocket formation by the H/ACA snoRNPs; base pairing between snR4 and 18S rRNA requires the putative helicase activity of Kre33p
transcript id: NR_132169.1
SIO_010081: YNCE0019W
subclass of: SO_0000673
so part of: YNCE0019W
location: 424698..424883
location: region:424698-424883:1
so has part: feature:424698-424883:1:exon

S000006493
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:424698-424883:1:exon

YER132C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PMD1
locus tag: YER132C
so part of: sequence
location: complement(<425188..>430449)
location: region:425188-430449:-1
so has part: feature:425188-430449:-1:exon
subclass of: SO_0000010

856869
type: Gene
SIO_000068: ncbigene

position:425188:-1
position: 425188
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:430449:-1
position: 430449
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:425188-430449:-1:exon

YER132C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PMD1
locus tag: YER132C
product: Pmd1p
transcript id: NM_001179022.3
SIO_010081: YER132C
subclass of: SO_0000673
so part of: YER132C
location: complement(<425188..>430449)
location: region:425188-430449:-1
so has part: feature:425188-430449:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:425188-430449:-1:exon

YER132C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PMD1
locus tag: YER132C
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9383076]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9383076]
note: Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication
codon start: 1
product: Pmd1p
translation: MTVLQPPSSVCYPLNLPIVPNPNLDEATRKKLTLECRTGAAVELARSGVFVHGGLTLPLNLTIINSLQLQKELILYFGKQKDRNADFKTLADWISPEIFFLDLISRTWQRINTTIDTTSENELNNGLSFKERLFHSMCFTESNIYIFGGLMVSPHNGYELIATNELWKLDLKTKCWSLISENPQITRRFNHSMHVLNENNENQDTKLIIVGGLDNMDIPVKKIDIFNLRTSLWESESKSDENPASKGSSKILVNIDGMPISLSHDSNFSVLIENNQAEIPTLALYYPQREANTSRRGTDDGSFSTYAHDLDDKSKLPKHHHHHHGDLKYFESDDADENAVKTLMSPIVILPLLGNSQGARMTSNPTQNNKENSILQVPFHLQYPSGNYFNYNIVVIGFYPDPQPSNLHCFIYNIASGKWIRVNIACTECSISMHRFWKLLIWKSHHQALLLGTRTDDFCSPSVQKFDHILSFSLPMLNGYNKLVNTKHTRTNNGIANSHNLNVNLSLYDHLPYSNSSTIEHTNPYTVTQGYSLDDSGIPRLTSTATSQFENYSRYITVPLEMESTSSIFPPYAMVLGKDALEIFGKTLSDFEFITADGDSIGVPVYLLRKRWGRYFDSLLSNGYANTSFNYEFNGDTSNIISFSPHTASKTTKFGNSSQSSNGSLEKYFSKNGNSKSNSNTSLKKPHSVDFTSSTSSPKQRAISHNKLSPSEPILCADEEDSRSNTLKQHATGDTGLKETGTSNKRPISTTCSSTGMVFRVPFQDMKNSKLGLSEQSGRSTRASSVSPPPVYKKSTNDGNDSNCTLSNTPLVYRRASTVGTTTNSSVDDGFSSIRRASHPLQSYIIAKSSPSSISKASPAEKAFSRRKSSALRFIASPNQSRQTSFASTASTASVVSSTSGRRRNSNQISHLGSSASLPNSPILPVLNIPLPPQEKIPLEPLPPVPKAPSRRSSSLAEYVQFGRDSPVASRRSSHSTRKSSSSDARRISNSSLLRNTLDSQLLSNSYGSDIPYEASIQEYGMNNGRDEEEDGDNQDYGCISPSNIRPIFSTINAININGNFKEGEFFSSKSYINNEKSRRLSYISNPESVESTNSNNNAIIELEPLLTPRSLYMPWSTASVRAFAEFFYTAQINGKWLLAPVTLDLLIMAKIYEIPILYELITEVLYKIISKKEEGLSVTCEALLNLFQQKVSRYCNENEGKIRKQLDSSESYQDTLEIKRSLANIDNGYVDSYLLRNTSMAQSIHYTDDSNGETEIDMHHTGISSIGSLANRAVPTVFAGGPRDSHNSIGSIAFPSNSGVQNIRRSVSLFSPATKKKSSLSRETDPLDTSDQFTDDVPDSGPVSRQQNFPRRSSSFTETVPTEPTRYNYQNLDSSKSNRASDDKEEQNEQATLQDISNFDKYKVETLQKRNSNDGKDLDRTNDPLKNRGTEIPQNSSNLETDPFIRDSFDSDSGSSFRSDSDDLDSQLGILPFTKMNKKLQEQTSQEFDDSIDPLYKIGSSTPGSSRLHGSFSKYIRPNSQREDGSEYVNISSLENMVSPNALPPVDYVMKSIYRTSVLVNDSNLMTRTKEAIELSKVLKKLKKKVLQDISQMDDEMRETGKPIFARGSSSPTLSRQHSDVATPLKQQENTRPALKFASSSPISEGFRKSSIKFSQAPSTQISPRTSVTDFTASQQRRQHMNKRFSTQTTHSTSALFMNPAFMPSAVNTGRKESEGHCEDRSATANRTNRKEDATTNDNDNIAPFPFFGKRR
SIO_010081: YER132C
subclass of: SO_0000673
so part of: YER132C
location: complement(425188..430449)
location: region:425188-430449:-1
so has part: feature:425188-430449:-1:exon

NP_011058.3
type: Protein
SIO_000068: ncbiprotein

S000000934
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:425188-430449:-1:exon

YNCE0020C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SNR52
locus tag: YNCE0020C
so part of: sequence
location: complement(431129..431220)
location: region:431129-431220:-1
so has part: feature:431129-431220:-1:exon
subclass of: SO_0000578

9164886
type: Gene
SIO_000068: ncbigene

position:431129:-1
position: 431129
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:431220:-1
position: 431220
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431129-431220:-1:exon

YNCE0020C
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: snoRNA
gene: SNR52
locus tag: YNCE0020C
product: SNR52
experiment: EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:10024243]
experiment: EXISTENCE:curator inference:GO:0031428 box C/D RNP complex [PMID:10024243]
experiment: EXISTENCE:genetic interaction:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:15546625]
experiment: EXISTENCE:genetic interaction:GO:0031167 rRNA methylation [PMID:15546625]
experiment: EXISTENCE:mutant phenotype:GO:0030562 rRNA 2'-O-ribose methylation guide activity [PMID:10024243|PMID:15546625]
experiment: EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:10024243|PMID:15546625]
note: C/D box small nucleolar RNA (snoRNA); guides 2'-O-methylation of large subunit (LSU) rRNA at position U2921 and small subunit (SSU) rRNA at position A420
transcript id: NR_132170.1
SIO_010081: YNCE0020C
subclass of: SO_0000673
so part of: YNCE0020C
location: complement(431129..431220)
location: region:431129-431220:-1
so has part: feature:431129-431220:-1:exon

S000006443
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:431129-431220:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(431490..431822)
location: region:431490-431822:-1
so has part: feature:431490-431822:-1:region

S000006895
type: SGD
SIO_000068: sgd

position:431490:-1
position: 431490
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:431822:-1
position: 431822
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:431490-431822:-1:region

YER133W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CID1
alternative label: DIS2
gene: GLC7
locus tag: YER133W
gene synonym: CID1; DIS2
so part of: sequence
location: <432495..>433958
location: region:432495-433958:1
so has part: feature:432495-433958:1:exon
subclass of: SO_0000010

856870
type: Gene
SIO_000068: ncbigene

position:432495:1
position: 432495
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:433958:1
position: 433958
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:432495-433958:1:exon

YER133W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CID1
alternative label: DIS2
gene: GLC7
locus tag: YER133W
gene synonym: CID1; DIS2
product: type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
transcript id: NM_001179023.3
SIO_010081: YER133W
subclass of: SO_0000673
so part of: YER133W
location: join(<432495..432671,433197..>433958)
location: region:432495-433958:1
so has part: feature:432495-432671:1:exon
so has part: feature:433197-433958:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:432495-432671:1:exon

position:432671:1
position: 432671
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:433197-433958:1:exon

position:433197:1
position: 433197
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YER133W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CID1
alternative label: DIS2
gene: GLC7
locus tag: YER133W
gene synonym: CID1; DIS2
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0000164 protein phosphatase type 1 complex [PMID:8289829]
experiment: EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19948764]
experiment: EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:10747092]
experiment: EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:1660885]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23418575]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11412094]
experiment: EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10747092]
experiment: EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11412094]
experiment: EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]
experiment: EXISTENCE:genetic interaction:GO:0000076 DNA replication checkpoint signaling [PMID:19884341]
experiment: EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:29529242]
experiment: EXISTENCE:genetic interaction:GO:0008360 regulation of cell shape [PMID:12477789]
experiment: EXISTENCE:genetic interaction:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:12356757]
experiment: EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:19884341]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:19884341]
experiment: EXISTENCE:mutant phenotype:GO:0006873 cellular ion homeostasis [PMID:11973298]
experiment: EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:25730376]
experiment: EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10072383]
experiment: EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10072380]
experiment: EXISTENCE:mutant phenotype:GO:0007116 regulation of cell budding [PMID:10639337]
experiment: EXISTENCE:mutant phenotype:GO:0007346 regulation of mitotic cell cycle [PMID:23418575]
experiment: EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10207049]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9584086]
experiment: EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:19884341]
experiment: EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19948764]
experiment: EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:10072380|PMID:7891699|PMID:8164671|PMID:9584086]
experiment: EXISTENCE:mutant phenotype:GO:0070873 regulation of glycogen metabolic process [PMID:1660885]
experiment: EXISTENCE:mutant phenotype:GO:1901901 regulation of protein localization to cell division site involved in cytokinesis [PMID:26771880]
experiment: EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:26771880]
experiment: EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:19948764]
experiment: EXISTENCE:physical interaction:GO:0051321 meiotic cell cycle [PMID:8754819]
note: Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple regulatory subunits; regulates actomyosin ring formation; subunit of CPF; recruited to mating projections by Afr1p interaction; regulates nucleocytoplasmic shuttling of Hxk2p; import into the nucleus is inhibited during spindle assembly checkpoint arrest; involved in dephosphorylating Rps6a/b and Bnr1p
codon start: 1
product: type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
translation: MDSQPVDVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQKSLPRQAGGRKKK
SIO_010081: YER133W
subclass of: SO_0000673
so part of: YER133W
location: join(432495..432671,433197..433958)
location: region:432495-433958:1
so has part: feature:432495-432671:1:exon
so has part: feature:433197-433958:1:exon

NP_011059.3
type: Protein
SIO_000068: ncbiprotein

S000000935
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:432495-432671:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:433197-433958:1:exon

YNCE0021C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0021C
so part of: sequence
location: complement(434541..434612)
location: region:434541-434612:-1
so has part: feature:434541-434612:-1:exon
subclass of: SO_0000663

856871
type: Gene
SIO_000068: ncbigene

position:434541:-1
position: 434541
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:434612:-1
position: 434612
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434541-434612:-1:exon

YNCE0021C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0021C
product: tRNA-His
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27609601]
experiment: EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:27609601]
note: Histidine tRNA (tRNA-His), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0021C
subclass of: SO_0000673
so part of: YNCE0021C
location: complement(434541..434612)
location: region:434541-434612:-1
so has part: feature:434541-434612:-1:exon

S000006594
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:434541-434612:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty3 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(434631..434971)
location: region:434631-434971:-1
so has part: feature:434631-434971:-1:region

S000006906
type: SGD
SIO_000068: sgd

position:434631:-1
position: 434631
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:434971:-1
position: 434971
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:434631-434971:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(435128..435447)
location: region:435128-435447:-1
so has part: feature:435128-435447:-1:region

S000006896
type: SGD
SIO_000068: sgd

position:435128:-1
position: 435128
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:435447:-1
position: 435447
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:435128-435447:-1:region

YNCE0022C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0022C
so part of: sequence
location: complement(435752..435824)
location: region:435752-435824:-1
so has part: feature:435752-435824:-1:exon
subclass of: SO_0000663

856872
type: Gene
SIO_000068: ncbigene

position:435752:-1
position: 435752
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:435824:-1
position: 435824
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:435752-435824:-1:exon

YNCE0022C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0022C
product: tRNA-Lys
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8915539]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8915539]
experiment: EXISTENCE:mutant phenotype:GO:0030533 triplet codon-amino acid adaptor activity [PMID:17560369]
experiment: EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]
note: Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE analysis; a small portion is imported into mitochondria via interaction with mt lysyl-tRNA synthetase Msk1p and is necessary to decode AAG codons at high temperature, when base modification of mt-encoded tRNA-Lys is reduced
SIO_010081: YNCE0022C
subclass of: SO_0000673
so part of: YNCE0022C
location: complement(435752..435824)
location: region:435752-435824:-1
so has part: feature:435752-435824:-1:exon

S000006619
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:435752-435824:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(435946..436277)
location: region:435946-436277:-1
so has part: feature:435946-436277:-1:region

S000006897
type: SGD
SIO_000068: sgd

position:435946:-1
position: 435946
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:436277:-1
position: 436277
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:435946-436277:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty4 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(436279..436605)
location: region:436279-436605:-1
so has part: feature:436279-436605:-1:region

S000006909
type: SGD
SIO_000068: sgd

position:436279:-1
position: 436279
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:436605:-1
position: 436605
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:436279-436605:-1:region

YER134C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER134C
so part of: sequence
location: complement(<437267..>437803)
location: region:437267-437803:-1
so has part: feature:437267-437803:-1:exon
subclass of: SO_0000010

856873
type: Gene
SIO_000068: ncbigene

position:437267:-1
position: 437267
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:437803:-1
position: 437803
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437267-437803:-1:exon

YER134C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER134C
product: Mg-dependent acid phosphatase
transcript id: NM_001179024.1
SIO_010081: YER134C
subclass of: SO_0000673
so part of: YER134C
location: complement(<437267..>437803)
location: region:437267-437803:-1
so has part: feature:437267-437803:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437267-437803:-1:exon

YER134C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER134C
EC number: 3.1.3.48
experiment: EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:11601995]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0030946 protein tyrosine phosphatase activity, metal-dependent [PMID:11601995]
note: Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene
codon start: 1
product: Mg-dependent acid phosphatase
translation: MTGYPDVAAFDLDYTIWPCYCDTHLHGPFKPVKSSNGEVLTIICRDGYELTIYKDIPRILGDLKDNGVKLMTASRTWAPEIAQEILKIFKVKYAGVVTPLANLFDEFQWGERSKIGHLRDGLKDLYNTSDLKSKKICLFDDESRNKEVEKYGVKFVYVRDPENGPSWKLYQDYLSGKV
SIO_010081: YER134C
subclass of: SO_0000673
so part of: YER134C
location: complement(437267..437803)
location: region:437267-437803:-1
so has part: feature:437267-437803:-1:exon

NP_011060.1
type: Protein
SIO_000068: ncbiprotein

S000000936
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437267-437803:-1:exon

YER135C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER135C
so part of: sequence
location: complement(<437952..>438344)
location: region:437952-438344:-1
so has part: feature:437952-438344:-1:exon
subclass of: SO_0000010

856874
type: Gene
SIO_000068: ncbigene

position:437952:-1
position: 437952
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:438344:-1
position: 438344
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:437952-438344:-1:exon

YER135C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER135C
product: uncharacterized protein
transcript id: NM_001348826.1
SIO_010081: YER135C
subclass of: SO_0000673
so part of: YER135C
location: complement(<437952..>438344)
location: region:437952-438344:-1
so has part: feature:437952-438344:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:437952-438344:-1:exon

YER135C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER135C
note: hypothetical protein; conserved among S. cerevisiae strains; YER135C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MTWTLRNLHNSQKKVLVDITIWLALSPYGDMALFTSFENIIGEYYRYSILPLHQNLHKLLFTLFLICLASWKEGNRSCRYKWQKFVCNKLNSPETNFVPIRTSVNKNSKMIVEKQISIHISLKCIVYKEY
SIO_010081: YER135C
subclass of: SO_0000673
so part of: YER135C
location: complement(437952..438344)
location: region:437952-438344:-1
so has part: feature:437952-438344:-1:exon

NP_001335768.1
type: Protein
SIO_000068: ncbiprotein

S000000937
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:437952-438344:-1:exon

YNCE0023W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0023W
so part of: sequence
location: 438700..438773
location: region:438700-438773:1
so has part: feature:438700-438773:1:exon
subclass of: SO_0000663

856875
type: Gene
SIO_000068: ncbigene

position:438700:1
position: 438700
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:438773:1
position: 438773
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438700-438773:1:exon

YNCE0023W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0023W
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0023W
subclass of: SO_0000673
so part of: YNCE0023W
location: 438700..438773
location: region:438700-438773:1
so has part: feature:438700-438773:1:exon

S000006753
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:438700-438773:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS518; Autonomously Replicating Sequence
so part of: sequence
location: 438934..439182
location: region:438934-439182:1
so has part: feature:438934-439182:1:region

S000077390
type: SGD
SIO_000068: sgd

position:438934:1
position: 438934
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:439182:1
position: 439182
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:438934-439182:1:region

YER136W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: SEC19
gene: GDI1
locus tag: YER136W
gene synonym: SEC19
so part of: sequence
location: <439616..>440971
location: region:439616-440971:1
so has part: feature:439616-440971:1:exon
subclass of: SO_0000010

856876
type: Gene
SIO_000068: ncbigene

position:439616:1
position: 439616
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:440971:1
position: 440971
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:439616-440971:1:exon

YER136W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: SEC19
gene: GDI1
locus tag: YER136W
gene synonym: SEC19
product: Gdi1p
transcript id: NM_001179026.1
SIO_010081: YER136W
subclass of: SO_0000673
so part of: YER136W
location: <439616..>440971
location: region:439616-440971:1
so has part: feature:439616-440971:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:439616-440971:1:exon

YER136W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: SEC19
gene: GDI1
locus tag: YER136W
gene synonym: SEC19
experiment: EXISTENCE:direct assay:GO:0005093 Rab GDP-dissociation inhibitor activity [PMID:8157010]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:8157010]
note: GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
codon start: 1
product: Gdi1p
translation: MDQETIDTDYDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYGGEAASVTLSQLYEKFKQNPISKEERESKFGKDRDWNVDLIPKFLMANGELTNILIHTDVTRYVDFKQVSGSYVFKQGKIYKVPANEIEAISSPLMGIFEKRRMKKFLEWISSYKEDDLSTHQGLDLDKNTMDEVYYKFGLGNSTKEFIGHAMALWTNDDYLQQPARPSFERILLYCQSVARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDTPIDEVLYKKDTGKFEGVKTKLGTFKAPLVIADPTYFPEKCKSTGQRVIRAICILNHPVPNTSNADSLQIIIPQSQLGRKSDIYVAIVSDAHNVCSKGHYLAIISTIIETDKPHIELEPAFKLLGPIEEKFMGIAELFEPREDGSKDNIYLSRSYDASSHFESMTDDVKDIYFRVTGHPLVLKQRQEQEKQ
SIO_010081: YER136W
subclass of: SO_0000673
so part of: YER136W
location: 439616..440971
location: region:439616-440971:1
so has part: feature:439616-440971:1:exon

NP_011062.1
type: Protein
SIO_000068: ncbiprotein

S000000938
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:439616-440971:1:exon

YER137C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER137C
so part of: sequence
location: complement(<441373..>441819)
location: region:441373-441819:-1
so has part: feature:441373-441819:-1:exon
subclass of: SO_0000010

856877
type: Gene
SIO_000068: ncbigene

position:441373:-1
position: 441373
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:441819:-1
position: 441819
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441373-441819:-1:exon

YER137C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER137C
product: uncharacterized protein
transcript id: NM_001179027.3
SIO_010081: YER137C
subclass of: SO_0000673
so part of: YER137C
location: complement(<441373..>441819)
location: region:441373-441819:-1
so has part: feature:441373-441819:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:441373-441819:-1:exon

YER137C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER137C
codon start: 1
product: uncharacterized protein
translation: MCESSNKTENDIVRLSQAMDVLAKLIISKQKDGSQLQVEYEHKLKELEKFINLLLGLHESTVGSMMNTSVLDMVLRNGIEIMEKDDQKYALIPIKAKEEADKTTSTIQGVTSKKSSKKKKNKIKCSFCHEAGHTRAHCGARLTVIPKK
SIO_010081: YER137C
subclass of: SO_0000673
so part of: YER137C
location: complement(441373..441819)
location: region:441373-441819:-1
so has part: feature:441373-441819:-1:exon

NP_011063.3
type: Protein
SIO_000068: ncbiprotein

S000000939
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441373-441819:-1:exon

YNCE0024W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCR1
locus tag: YNCE0024W
so part of: sequence
location: 441987..442508
location: region:441987-442508:1
so has part: feature:441987-442508:1:exon
subclass of: SO_0000642

9164887
type: Gene
SIO_000068: ncbigene

position:441987:1
position: 441987
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:442508:1
position: 442508
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:441987-442508:1:exon

YNCE0024W
type: Non Coding RNA
subclass of: SO_0000655
RO_0002162: 559292
nc RNA class: SRP_RNA
gene: SCR1
locus tag: YNCE0024W
product: SCR1
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18418087]
experiment: EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]
experiment: EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]
experiment: EXISTENCE:mutant phenotype:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:1655273]
experiment: EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:7925282]
note: RNA subunit of the Signal Recognition Particle (SRP)
transcript id: NR_132171.1
SIO_010081: YNCE0024W
subclass of: SO_0000673
so part of: YNCE0024W
location: 441987..442508
location: region:441987-442508:1
so has part: feature:441987-442508:1:exon

S000006491
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:441987-442508:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS519; Autonomously Replicating Sequence
so part of: sequence
location: 442416..442735
location: region:442416-442735:1
so has part: feature:442416-442735:1:region

S000077391
type: SGD
SIO_000068: sgd

position:442416:1
position: 442416
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:442735:1
position: 442735
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442416-442735:1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 442734..443072
location: region:442734-443072:1
so has part: feature:442734-443072:1:region

S000006917
type: SGD
SIO_000068: sgd

position:442734:1
position: 442734
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:443072:1
position: 443072
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:442734-443072:1:region

YNCE0025C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0025C
so part of: sequence
location: complement(443202..443275)
location: region:443202-443275:-1
so has part: feature:443202-443275:-1:exon
subclass of: SO_0000663

856878
type: Gene
SIO_000068: ncbigene

position:443202:-1
position: 443202
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:443275:-1
position: 443275
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443202-443275:-1:exon

YNCE0025C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0025C
product: tRNA-Ile
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0025C
subclass of: SO_0000673
so part of: YNCE0025C
location: complement(443202..443275)
location: region:443202-443275:-1
so has part: feature:443202-443275:-1:exon

S000006602
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:443202-443275:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YERCTy1-1; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YERCTy1-1
so part of: sequence
location: complement(443397..449320)
location: region:443397-449320:-1
so has part: feature:443397-449320:-1:region

S000006910
type: SGD
SIO_000068: sgd

position:443397:-1
position: 443397
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:449320:-1
position: 449320
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443397-449320:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(443397..443733)
location: region:443397-443733:-1
so has part: feature:443397-443733:-1:region

S000006898
type: SGD
SIO_000068: sgd

position:443733:-1
position: 443733
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443397-443733:-1:region

YER138C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER138C
so part of: sequence
location: complement(<443756..>449024)
location: region:443756-449024:-1
so has part: feature:443756-449024:-1:exon
subclass of: SO_0000010

856879
type: Gene
SIO_000068: ncbigene

position:443756:-1
position: 443756
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449024:-1
position: 449024
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:443756-449024:-1:exon

YER138C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER138C
product: gag-pol fusion protein
transcript id: NM_001179028.4
SIO_010081: YER138C
subclass of: SO_0000673
so part of: YER138C
location: complement(<443756..>449024)
location: region:443756-449024:-1
so has part: feature:443756-449024:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:443756-449024:-1:exon

YER138C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER138C
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSDDLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDFRHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSHNIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YER138C
subclass of: SO_0000673
so part of: YER138C
location: complement(join(443756..447721,447723..449024))
location: region:443756-449024:-1
so has part: feature:447723-449024:-1:exon
so has part: feature:443756-447721:-1:exon

NP_011064.3
type: Protein
SIO_000068: ncbiprotein

S000000940
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447723-449024:-1:exon

position:447723:-1
position: 447723
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:443756-447721:-1:exon

position:447721:-1
position: 447721
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 444834..445139
location: region:444834-445139:1
so has part: feature:444834-445139:1:region

S000006919
type: SGD
SIO_000068: sgd

position:444834:1
position: 444834
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:445139:1
position: 445139
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:444834-445139:1:region

YER137C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER137C-A
so part of: sequence
location: complement(<447702..>449024)
location: region:447702-449024:-1
so has part: feature:447702-449024:-1:exon
subclass of: SO_0000010

856880
type: Gene
SIO_000068: ncbigene

position:447702:-1
position: 447702
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:447702-449024:-1:exon

YER137C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER137C-A
product: gag protein
transcript id: NM_001184428.1
SIO_010081: YER137C-A
subclass of: SO_0000673
so part of: YER137C-A
location: complement(<447702..>449024)
location: region:447702-449024:-1
so has part: feature:447702-449024:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:447702-449024:-1:exon

YER137C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER137C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
SIO_010081: YER137C-A
subclass of: SO_0000673
so part of: YER137C-A
location: complement(447702..449024)
location: region:447702-449024:-1
so has part: feature:447702-449024:-1:exon

NP_058155.1
type: Protein
SIO_000068: ncbiprotein

S000007402
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:447702-449024:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(448984..449320)
location: region:448984-449320:-1
so has part: feature:448984-449320:-1:region

S000006899
type: SGD
SIO_000068: sgd

position:448984:-1
position: 448984
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:448984-449320:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 449274..449626
location: region:449274-449626:1
so has part: feature:449274-449626:1:region

S000303805
type: SGD
SIO_000068: sgd

position:449274:1
position: 449274
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:449626:1
position: 449626
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449274-449626:1:region

YER138W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER138W-A
so part of: sequence
location: <449474..>449578
location: region:449474-449578:1
so has part: feature:449474-449578:1:exon
subclass of: SO_0000010

856881
type: Gene
SIO_000068: ncbigene

position:449474:1
position: 449474
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:449578:1
position: 449578
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:449474-449578:1:exon

YER138W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER138W-A
product: uncharacterized protein
transcript id: NM_001184332.1
SIO_010081: YER138W-A
subclass of: SO_0000673
so part of: YER138W-A
location: <449474..>449578
location: region:449474-449578:1
so has part: feature:449474-449578:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:449474-449578:1:exon

YER138W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER138W-A
note: hypothetical protein; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication
codon start: 1
product: uncharacterized protein
translation: MIIIFIELCRIADSLLWIPKSSRRTSSISTYLIL
SIO_010081: YER138W-A
subclass of: SO_0000673
so part of: YER138W-A
location: 449474..449578
location: region:449474-449578:1
so has part: feature:449474-449578:1:exon

NP_011065.1
type: Protein
SIO_000068: ncbiprotein

S000007239
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:449474-449578:1:exon

YER139C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RTR1
locus tag: YER139C
so part of: sequence
location: complement(<450563..>451243)
location: region:450563-451243:-1
so has part: feature:450563-451243:-1:exon
subclass of: SO_0000010

856882
type: Gene
SIO_000068: ncbigene

position:450563:-1
position: 450563
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:451243:-1
position: 451243
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:450563-451243:-1:exon

YER139C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RTR1
locus tag: YER139C
product: RNA polymerase II subunit B1 CTD phosphatase RTR1
transcript id: NM_001179029.3
SIO_010081: YER139C
subclass of: SO_0000673
so part of: YER139C
location: complement(<450563..>451243)
location: region:450563-451243:-1
so has part: feature:450563-451243:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:450563-451243:-1:exon

YER139C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RTR1
locus tag: YER139C
EC number: 3.1.3.16
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18408053]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18408053|PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:19394294]
experiment: EXISTENCE:direct assay:GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain [PMID:19394294]
experiment: EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:18408053]
experiment: EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:18408053]
experiment: EXISTENCE:mutant phenotype:GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain [PMID:19394294]
experiment: EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:18408053]
note: Dual specificity protein phosphatase; dephosphorylates T1 and S5 in C-terminal domain (CTD) of RNA polymerase II largest subunit, Rpo21p; autoregulates turnover of its mRNA; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication
codon start: 1
product: RNA polymerase II subunit B1 CTD phosphatase RTR1
translation: MATIEDIKETALIPFQKHRQLSMHEAEVITLEIIGLLCDSECKDEKTLKYLGRFLTPDMYQDLVDERNLNKRCGYPLCGKSPERIRDPFSMNDTTKKFLLENNPYAYLSHYCSKFHFRCSQFYQVQLSDEALFARTGVHLFEDPEQDKHDIDFKVTLFEELLREKASEEDIKSLISGLKKLGLNPDSGTTEKDDTELEDDLSKWLAQIKIVENDNPSILGDFTRED
SIO_010081: YER139C
subclass of: SO_0000673
so part of: YER139C
location: complement(450563..451243)
location: region:450563-451243:-1
so has part: feature:450563-451243:-1:exon

NP_011066.3
type: Protein
SIO_000068: ncbiprotein

S000000941
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:450563-451243:-1:exon

YER140W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: EMP65
locus tag: YER140W
so part of: sequence
location: <451565..>453235
location: region:451565-453235:1
so has part: feature:451565-453235:1:exon
subclass of: SO_0000010

856883
type: Gene
SIO_000068: ncbigene

position:451565:1
position: 451565
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:453235:1
position: 453235
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:451565-453235:1:exon

YER140W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: EMP65
locus tag: YER140W
product: Emp65p
transcript id: NM_001179030.3
SIO_010081: YER140W
subclass of: SO_0000673
so part of: YER140W
location: <451565..>453235
location: region:451565-453235:1
so has part: feature:451565-453235:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:451565-453235:1:exon

YER140W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: EMP65
locus tag: YER140W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:23275891]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]
note: Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Emp65p
translation: MQHKDTAVAKDTAKKRLLRRNSAPSAIHIISRLDKKWSFLWNTIDRHNIVEEQDESSAAKSEEEHEDDYELEQLLNMIRIPMFLEKFMLFALLTSLDCFLYYFTVLPIRLIKGYVKQFKSYRQHYRLQQRSGHKNKIPFRYRITSREYKERCMIFIIVISSILLSKLDTSKLYHRIKRQSTMKLYMLFSVLEMADKMLASLGQSLLTVMLSRKNSERILLHKCLLVSMSLTYVTIHGYVLVYQAISLNIAVNSYSNALLTLLLSMQFAEIKSSVLKKFDKEGFFQITIADVVERFKLTLLLSITGLRNLQSWSSSLSNTSINFWSPRSTLSIVINILCGPMVSVVGSEVLVDWAKHAYITKFNRIRPQIYDKFYYIIYKDYSTRTHKLEDRLGLPLPAFVVLFIVMVRPTLFKSSEPSYLPSLFRILFMGASVFLLALLAKFTLDLILIKWSKRIEQRFRDQAFNTVVTEEEYVPGLLSGGMGKVDVSTRIALHSDYNKENRIETESVSPMRKRKTTLTAECTPPSLNDIRRQKDSKNPRSLENVARYKMVSKRIW
SIO_010081: YER140W
subclass of: SO_0000673
so part of: YER140W
location: 451565..453235
location: region:451565-453235:1
so has part: feature:451565-453235:1:exon

NP_011067.3
type: Protein
SIO_000068: ncbiprotein

S000000942
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:451565-453235:1:exon

YER141W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: COX15
locus tag: YER141W
so part of: sequence
location: <453459..>454919
location: region:453459-454919:1
so has part: feature:453459-454919:1:exon
subclass of: SO_0000010

856884
type: Gene
SIO_000068: ncbigene

position:453459:1
position: 453459
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:454919:1
position: 454919
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:453459-454919:1:exon

YER141W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: COX15
locus tag: YER141W
product: Cox15p
transcript id: NM_001179031.1
SIO_010081: YER141W
subclass of: SO_0000673
so part of: YER141W
location: <453459..>454919
location: region:453459-454919:1
so has part: feature:453459-454919:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:453459-454919:1:exon

YER141W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: COX15
locus tag: YER141W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9228094]
experiment: EXISTENCE:genetic interaction:GO:0006784 heme A biosynthetic process [PMID:11788607]
experiment: EXISTENCE:genetic interaction:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:11788607]
experiment: EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:11788607]
experiment: EXISTENCE:mutant phenotype:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:26940873|PMID:11248251]
note: Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function
codon start: 1
product: Cox15p
translation: MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQLYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLGGLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIFFMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSGLDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFKKLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMDENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMTSLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRNVIITLPHSSKVTSGKILSEASKLASKPL
SIO_010081: YER141W
subclass of: SO_0000673
so part of: YER141W
location: 453459..454919
location: region:453459-454919:1
so has part: feature:453459-454919:1:exon

NP_011068.1
type: Protein
SIO_000068: ncbiprotein

S000000943
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:453459-454919:1:exon

YER142C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: MMS5
gene: MAG1
locus tag: YER142C
gene synonym: MMS5
so part of: sequence
location: complement(<455146..>456036)
location: region:455146-456036:-1
so has part: feature:455146-456036:-1:exon
subclass of: SO_0000010

856885
type: Gene
SIO_000068: ncbigene

position:455146:-1
position: 455146
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:456036:-1
position: 456036
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:455146-456036:-1:exon

YER142C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: MMS5
gene: MAG1
locus tag: YER142C
gene synonym: MMS5
product: DNA-3-methyladenine glycosylase II
transcript id: NM_001179032.1
SIO_010081: YER142C
subclass of: SO_0000673
so part of: YER142C
location: complement(<455146..>456036)
location: region:455146-456036:-1
so has part: feature:455146-456036:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:455146-456036:-1:exon

YER142C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: MMS5
gene: MAG1
locus tag: YER142C
gene synonym: MMS5
EC number: 3.2.2.21
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:2265619]
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:18472311]
experiment: EXISTENCE:direct assay:GO:0003905 alkylbase DNA N-glycosylase activity [PMID:2682633|PMID:2265619]
experiment: EXISTENCE:direct assay:GO:0008725 DNA-3-methyladenine glycosylase activity [PMID:18472311]
experiment: EXISTENCE:genetic interaction:GO:0006285 base-excision repair, AP site formation [PMID:18043759]
experiment: EXISTENCE:mutant phenotype:GO:0006285 base-excision repair, AP site formation [PMID:18043759]
experiment: EXISTENCE:mutant phenotype:GO:0006307 DNA dealkylation involved in DNA repair [PMID:2265620]
note: 3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress
codon start: 1
product: DNA-3-methyladenine glycosylase II
translation: MKLKREYDELIKADAVKEIAKELGSRPLEVALPEKYIARHEEKFNMACEHILEKDPSLFPILKNNEFTLYLKETQVPNTLEDYFIRLASTILSQQISGQAAESIKARVVSLYGGAFPDYKILFEDFKDPAKCAEIAKCGLSKRKMIYLESLAVYFTEKYKDIEKLFGQKDNDEEVIESLVTNVKGIGPWSAKMFLISGLKRMDVFAPEDLGIARGFSKYLSDKPELEKELMRERKVVKKSKIKHKKYNWKIYDDDIMEKCSETFSPYRSVFMFILWRLASTNTDAMMKAEENFVKS
SIO_010081: YER142C
subclass of: SO_0000673
so part of: YER142C
location: complement(455146..456036)
location: region:455146-456036:-1
so has part: feature:455146-456036:-1:exon

NP_011069.1
type: Protein
SIO_000068: ncbiprotein

S000000944
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:455146-456036:-1:exon

YER143W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: VSM1
gene: DDI1
locus tag: YER143W
gene synonym: VSM1
so part of: sequence
location: <456319..>457605
location: region:456319-457605:1
so has part: feature:456319-457605:1:exon
subclass of: SO_0000010

856886
type: Gene
SIO_000068: ncbigene

position:456319:1
position: 456319
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:457605:1
position: 457605
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:456319-457605:1:exon

YER143W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: VSM1
gene: DDI1
locus tag: YER143W
gene synonym: VSM1
product: Ddi1p
transcript id: NM_001179033.3
SIO_010081: YER143W
subclass of: SO_0000673
so part of: YER143W
location: <456319..>457605
location: region:456319-457605:1
so has part: feature:456319-457605:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:456319-457605:1:exon

YER143W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: VSM1
gene: DDI1
locus tag: YER143W
gene synonym: VSM1
experiment: EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:10330187]
experiment: EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:32193351]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10330187]
experiment: EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:15964793]
experiment: EXISTENCE:direct assay:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:32193351]
experiment: EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11323716]
experiment: EXISTENCE:direct assay:GO:1904855 proteasome regulatory particle binding [PMID:15964793]
experiment: EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0004190 aspartic-type endopeptidase activity [PMID:32193351]
experiment: EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12051757]
experiment: EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:21094643]
experiment: EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:10330187]
experiment: EXISTENCE:mutant phenotype:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:32193351]
experiment: EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]
experiment: EXISTENCE:mutant phenotype:GO:0045740 positive regulation of DNA replication [PMID:31276951]
note: Aspartic-type endopeptidase; involved in the cleavage of long-chain polyubiquitinated substrates; role in proteasome-independent, ubiquitin (Ub)-dependent proteolysis and DNA-protein crosslink repair; Ub-shuttle receptor for HO and Ufo1p; DNA damage-inducible v-SNARE binding protein and negative regulator of constitutive exocytosis; possible role in the S-phase checkpoint; UBL-UBA family member containing Ub-like (UBL), helical, Ub-associated (UBA) and retroviral-like proteinase (RVP) domains
codon start: 1
product: Ddi1p
translation: MDLTISNELTGEIYGPIEVSEDMALTDLIALLQADCGFDKTKHDLYYNMDILDSNRTQSLKELGLKTDDLLLIRGKISNSIQTDAATLSDEAFIEQFRQELLNNQMLRSQLILQIPGLNDLVNDPLLFRERLGPLILQRRYGGYNTAMNPFGIPQDEYTRLMANPDDPDNKKRIAELLDQQAIDEQLRNAIEYTPEMFTQVPMLYINIEINNYPVKAFVDTGAQTTIMSTRLAKKTGLSRMIDKRFIGEARGVGTGKIIGRIHQAQVKIETQYIPCSFTVLDTDIDVLIGLDMLKRHLACVDLKENVLRIAEVETSFLSEAEIPKSFQEGLPAPTSVTTSSDKPLTPTKTSSTLPPQPGAVPALAPRTGMGPTPTGRSTAGATTATGRTFPEQTIKQLMDLGFPRDAVVKALKQTNGNAEFAASLLFQ
SIO_010081: YER143W
subclass of: SO_0000673
so part of: YER143W
location: 456319..457605
location: region:456319-457605:1
so has part: feature:456319-457605:1:exon

NP_011070.3
type: Protein
SIO_000068: ncbiprotein

S000000945
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:456319-457605:1:exon

YER144C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: UBP5
locus tag: YER144C
so part of: sequence
location: complement(<457806..>460223)
location: region:457806-460223:-1
so has part: feature:457806-460223:-1:exon
subclass of: SO_0000010

856887
type: Gene
SIO_000068: ncbigene

position:457806:-1
position: 457806
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:460223:-1
position: 460223
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:457806-460223:-1:exon

YER144C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: UBP5
locus tag: YER144C
product: putative ubiquitin-specific protease UBP5
transcript id: NM_001179034.3
SIO_010081: YER144C
subclass of: SO_0000673
so part of: YER144C
location: complement(<457806..>460223)
location: region:457806-460223:-1
so has part: feature:457806-460223:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:457806-460223:-1:exon

YER144C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: UBP5
locus tag: YER144C
EC number: 3.4.19.12
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17145966]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17145966]
note: Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication
codon start: 1
product: putative ubiquitin-specific protease UBP5
translation: MGSEQALSEVVESAKERFGRLRHLVQKFLDDDDVPQECLPLLQECAEIWSSYVDACQDITMQAPKEDANRLSKGFLRLNETAFLYYMIVYTLLEDTLPRLKEFSSNKDQNVRNLYGERIQLLHNDPNIERIRNVIENYPKFIQLQTIEPGKLSSMLHFHGDALLLIDVRPRSEFVRAHIKCKNIICIDPASFKDSFTDQQIESVSLITSPHSDITFFSNRDKFKFIILYTDTQLHNNFQQRQTRILAKILSQNSVIKPLSGTKILILENGFSNWVKLGGAYQSSVSETAHLTSSSSTPAFGSPQVPTGLFNQKSLSPNKDKSMPMVSMNTQPLLTTVQRPQLPLYYSDLPIIPQPSPNRNSPTVQKFSPHPPTTLSKLNTPSTIQNKANTVERISPDIRAAQAHAYLPPASNVFSPRIPPLPQQNLSSSRQTILNNSQVLDLDLIVGLENIGNCCYMNCILQCLVGTHDLVRMFLDNTYLNFINFDSSRGSKGLLAKNFAILVNNMHRHGAFTPPNVRTIPVQTIQFKKICGHINPMYSDSMQQDCQEFCQFLLDGLHEDLNQNGSKKHLKQLSDEEERMREKMSIRKASALEWERFLLTDFSAIIDLFQGQYASRLQCQVCEHTSTTYQTFSVLSVPVPRVKTCNILDCFREFTKCERLGVDEQWSCPKCLKKQPSTKQLKITRLPKKLIINLKRFDNQMNKNNVFVQYPYSLDLTPYWARDFNHEAIVNEDIPTRGQVPPFRYRLYGVACHSGSLYGGHYTSYVYKGPKKGWYFFDDSLYRPITFSTEFITPSAYVLFYERIF
SIO_010081: YER144C
subclass of: SO_0000673
so part of: YER144C
location: complement(457806..460223)
location: region:457806-460223:-1
so has part: feature:457806-460223:-1:exon

NP_011071.3
type: Protein
SIO_000068: ncbiprotein

S000000946
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:457806-460223:-1:exon

YER145C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FTR1
locus tag: YER145C
so part of: sequence
location: complement(<460526..>461740)
location: region:460526-461740:-1
so has part: feature:460526-461740:-1:exon
subclass of: SO_0000010

856888
type: Gene
SIO_000068: ncbigene

position:460526:-1
position: 460526
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:461740:-1
position: 461740
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:460526-461740:-1:exon

YER145C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FTR1
locus tag: YER145C
product: high-affinity iron permease FTR1
transcript id: NM_001179035.1
SIO_010081: YER145C
subclass of: SO_0000673
so part of: YER145C
location: complement(<460526..>461740)
location: region:460526-461740:-1
so has part: feature:460526-461740:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:460526-461740:-1:exon

YER145C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FTR1
locus tag: YER145C
experiment: EXISTENCE:direct assay:GO:0005381 iron ion transmembrane transporter activity [PMID:16700543|PMID:8599111]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10748025|PMID:16700543]
experiment: EXISTENCE:direct assay:GO:0033573 high-affinity iron permease complex [PMID:16522632]
experiment: EXISTENCE:genetic interaction:GO:0034755 iron ion transmembrane transport [PMID:8599111]
experiment: EXISTENCE:genetic interaction:GO:1901684 arsenate ion transmembrane transport [PMID:23295455]
experiment: EXISTENCE:mutant phenotype:GO:0034755 iron ion transmembrane transport [PMID:16700543|PMID:8599111]
note: High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
codon start: 1
product: high-affinity iron permease FTR1
translation: MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYRKLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMGIPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAVVFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLISAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKNKKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHVKADSL
SIO_010081: YER145C
subclass of: SO_0000673
so part of: YER145C
location: complement(460526..461740)
location: region:460526-461740:-1
so has part: feature:460526-461740:-1:exon

NP_011072.1
type: Protein
SIO_000068: ncbiprotein

S000000947
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:460526-461740:-1:exon

YER145C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER145C-A
so part of: sequence
location: complement(<462386..>462823)
location: region:462386-462823:-1
so has part: feature:462386-462823:-1:exon
subclass of: SO_0000010

31009439
type: Gene
SIO_000068: ncbigene

position:462386:-1
position: 462386
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462823:-1
position: 462823
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462386-462823:-1:exon

YER145C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER145C-A
product: uncharacterized protein
transcript id: NM_001348827.1
SIO_010081: YER145C-A
subclass of: SO_0000673
so part of: YER145C-A
location: complement(<462386..>462823)
location: region:462386-462823:-1
so has part: feature:462386-462823:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462386-462823:-1:exon

YER145C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER145C-A
note: hypothetical protein; conserved among S. cerevisiae strains; overlaps verified ORF LSM5/YER146W
codon start: 1
product: uncharacterized protein
translation: MAILLPLKSILPWCCITFSFLLSSSGSISHSTASSSITLTKSSKPTNVPSNSRFDCSTINTFWLIVLSMTSKGKISGRLILRASVYACECTCIRYACCETIYPPRKPFSLSLYFFYFNKKASILFCYPDAKTKPEHPGNKRAGSG
SIO_010081: YER145C-A
subclass of: SO_0000673
so part of: YER145C-A
location: complement(462386..462823)
location: region:462386-462823:-1
so has part: feature:462386-462823:-1:exon

NP_001335769.1
type: Protein
SIO_000068: ncbiprotein

S000028758
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462386-462823:-1:exon

YER146W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: LSM5
locus tag: YER146W
so part of: sequence
location: <462585..>462866
location: region:462585-462866:1
so has part: feature:462585-462866:1:exon
subclass of: SO_0000010

856889
type: Gene
SIO_000068: ncbigene

position:462585:1
position: 462585
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:462866:1
position: 462866
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462585-462866:1:exon

YER146W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: LSM5
locus tag: YER146W
product: RNA-binding protein LSM5
transcript id: NM_001179036.1
SIO_010081: YER146W
subclass of: SO_0000673
so part of: YER146W
location: <462585..>462866
location: region:462585-462866:1
so has part: feature:462585-462866:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462585-462866:1:exon

YER146W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: LSM5
locus tag: YER146W
experiment: EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684|PMID:15075370]
experiment: EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]
experiment: EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]
experiment: EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]
experiment: EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]
note: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
codon start: 1
product: RNA-binding protein LSM5
translation: MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVILEDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL
SIO_010081: YER146W
subclass of: SO_0000673
so part of: YER146W
location: 462585..462866
location: region:462585-462866:1
so has part: feature:462585-462866:1:exon

NP_011073.1
type: Protein
SIO_000068: ncbiprotein

S000000948
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462585-462866:1:exon

YER147C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SCC4
locus tag: YER147C
so part of: sequence
location: complement(<462968..>464842)
location: region:462968-464842:-1
so has part: feature:462968-464842:-1:exon
subclass of: SO_0000010

856890
type: Gene
SIO_000068: ncbigene

position:462968:-1
position: 462968
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:464842:-1
position: 464842
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:462968-464842:-1:exon

YER147C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SCC4
locus tag: YER147C
product: cohesin-loading factor complex subunit SCC4
transcript id: NM_001179037.3
SIO_010081: YER147C
subclass of: SO_0000673
so part of: YER147C
location: complement(<462968..>464842)
location: region:462968-464842:-1
so has part: feature:462968-464842:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:462968-464842:-1:exon

YER147C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SCC4
locus tag: YER147C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10882066]
experiment: EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:28938124]
experiment: EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:15610742]
experiment: EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:10882066]
experiment: EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:18708580]
experiment: EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18708580]
experiment: EXISTENCE:mutant phenotype:GO:0071169 establishment of protein localization to chromatin [PMID:10882066]
experiment: EXISTENCE:physical interaction:GO:0032116 SMC loading complex [PMID:10882066]
note: Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
codon start: 1
product: cohesin-loading factor complex subunit SCC4
translation: MENLGDKLSISQVYHLAQEYRDHAYSIANKIGSEEGLKQYYGLMNMSIQMFQLLKTKCTLSVLEDSKVTFEMVELLIQETYNFDLAELYISSLKERLQTHQSDTDLVEEIMRCEFLLLHDLPLMRDSKFHYKIALRNCNELVQYMVNLQDELYQNWASVFQYVGVMLCIKLKQHRRVKTSFHGLLSQCREKSQWKWFLNLCYVNYLLNERFPIPEDALQELRSTELHTVGPELYAWKLALEMVIQLCKDGNITDHLNEFKNFFDTNKQSLVTNEGKGCVIKIMPRIALKVELPMIFHYKELKNILLLLQSVSYIVNCYDEKGNFSRKFLPKVYSTTQKLIKNIAAGGVSMNELDSRIQTYKSILEFCEFYKVWEQTLLKGAVVTTESPKLGPSPGYVRLLQAMKVQFEGGGAVEEYTRLAQSGGTSSEVKMISLLNCYTVQAARVSRCSGDKQGELVEQCNKVWLQVEKLLQETDLQFNPIWECTVTILWLFSHFEPFSWNPLPCSDKQRAEYVSKLREFYSSNKFVAGEAVADNRFKLKKALLLQILVNYLGGRMLEHDLGEIYAISAKCFDMCRQQGGMRKVQYVIGIWHLMNCTVAMRGKDVALTNAKLEALVKQITSVKQ
SIO_010081: YER147C
subclass of: SO_0000673
so part of: YER147C
location: complement(462968..464842)
location: region:462968-464842:-1
so has part: feature:462968-464842:-1:exon

NP_011074.3
type: Protein
SIO_000068: ncbiprotein

S000000949
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:462968-464842:-1:exon

YER148W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BTF1
alternative label: TBP1
gene: SPT15
locus tag: YER148W
gene synonym: BTF1; TBP1
so part of: sequence
location: <465303..>466025
location: region:465303-466025:1
so has part: feature:465303-466025:1:exon
subclass of: SO_0000010

856891
type: Gene
SIO_000068: ncbigene

position:465303:1
position: 465303
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:466025:1
position: 466025
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:465303-466025:1:exon

YER148W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BTF1
alternative label: TBP1
gene: SPT15
locus tag: YER148W
gene synonym: BTF1; TBP1
product: TATA-binding protein
transcript id: NM_001179038.3
SIO_010081: YER148W
subclass of: SO_0000673
so part of: YER148W
location: <465303..>466025
location: region:465303-466025:1
so has part: feature:465303-466025:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:465303-466025:1:exon

YER148W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BTF1
alternative label: TBP1
gene: SPT15
locus tag: YER148W
gene synonym: BTF1; TBP1
experiment: EXISTENCE:curator inference:GO:0000995 RNA polymerase III general transcription initiation factor activity []
experiment: EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity []
experiment: EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:1423590|PMID:1458536]
experiment: EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:2677740]
experiment: EXISTENCE:direct assay:GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding [PMID:8662956]
experiment: EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:8895657]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:19098311]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9818719]
experiment: EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]
experiment: EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:1736286]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
experiment: EXISTENCE:direct assay:GO:0070893 transposon integration [PMID:10882723]
experiment: EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:1480467]
experiment: EXISTENCE:mutant phenotype:GO:0001188 RNA polymerase I preinitiation complex assembly [PMID:8895657]
experiment: EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:1586947]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]
experiment: EXISTENCE:physical interaction:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:8895657]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]
note: TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP
codon start: 1
product: TATA-binding protein
translation: MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEEDIKRAAPESEKDTSATSGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYQAFEAIYPVLSEFRKM
SIO_010081: YER148W
subclass of: SO_0000673
so part of: YER148W
location: 465303..466025
location: region:465303-466025:1
so has part: feature:465303-466025:1:exon

NP_011075.3
type: Protein
SIO_000068: ncbiprotein

S000000950
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:465303-466025:1:exon

YER149C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: DFG9
alternative label: PPF2
gene: PEA2
locus tag: YER149C
gene synonym: DFG9; PPF2
so part of: sequence
location: complement(<466208..>467470)
location: region:466208-467470:-1
so has part: feature:466208-467470:-1:exon
subclass of: SO_0000010

856892
type: Gene
SIO_000068: ncbigene

position:466208:-1
position: 466208
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:467470:-1
position: 467470
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:466208-467470:-1:exon

YER149C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: DFG9
alternative label: PPF2
gene: PEA2
locus tag: YER149C
gene synonym: DFG9; PPF2
product: Pea2p
transcript id: NM_001179039.1
SIO_010081: YER149C
subclass of: SO_0000673
so part of: YER149C
location: complement(<466208..>467470)
location: region:466208-467470:-1
so has part: feature:466208-467470:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:466208-467470:-1:exon

YER149C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: DFG9
alternative label: PPF2
gene: PEA2
locus tag: YER149C
gene synonym: DFG9; PPF2
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8909546]
experiment: EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9632790]
experiment: EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:8909546]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8909546]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8909546]
experiment: EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:33656555]
experiment: EXISTENCE:direct assay:GO:0031489 myosin V binding [PMID:33656555]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:8909546|PMID:19053807]
experiment: EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]
experiment: EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:8909546]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]
experiment: EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8013906|PMID:8909546|PMID:33656555]
experiment: EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]
experiment: EXISTENCE:mutant phenotype:GO:0031384 regulation of initiation of mating projection growth [PMID:14734532]
experiment: EXISTENCE:mutant phenotype:GO:0031385 regulation of termination of mating projection growth [PMID:14734532]
experiment: EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10085294|PMID:11740491|PMID:8909546]
experiment: EXISTENCE:mutant phenotype:GO:2000251 positive regulation of actin cytoskeleton reorganization [PMID:17237521|PMID:19633059]
note: Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion
codon start: 1
product: Pea2p
translation: MHKFDLELSRRANPLLFSAERYEEYPLKYDELKQYLLSQNPSHPHHNSRPYTSIDYFDYLLYRSKNDESEIDLDKKLVSEFALYYVQKEHLNSDDLNPTLNELLKLQPKSADWYEMMLRILESINTTGIDQLTKENNNSFPNSKRARSSTNMGGTDKFNKGAYHTDKADDDKNEILQELTSFLMSNSIQKGIDIKPIPLDDPVKFLKNGINSILDTCVSLEKNTSSPPISPNAAAIQEEDSSKKLEELETAFSDLQLAHNFLTKQFENDRAEYVQDIEKLTRTNRELQDKLLNNHSNLSKTEKKLHELEQENKELEKANNKLNSSRHNFGMSSPASSPVTWDPSSPSSVGSPTSGSGSRSLSIMTSEFKKVLTSTQRKYEKELSDEREHRFKLERELALLKNAEANTSLALNRDDPPDML
SIO_010081: YER149C
subclass of: SO_0000673
so part of: YER149C
location: complement(466208..467470)
location: region:466208-467470:-1
so has part: feature:466208-467470:-1:exon

NP_011076.1
type: Protein
SIO_000068: ncbiprotein

S000000951
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:466208-467470:-1:exon

YER150W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SPI1
locus tag: YER150W
so part of: sequence
location: <468370..>468816
location: region:468370-468816:1
so has part: feature:468370-468816:1:exon
subclass of: SO_0000010

856893
type: Gene
SIO_000068: ncbigene

position:468370:1
position: 468370
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:468816:1
position: 468816
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:468370-468816:1:exon

YER150W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SPI1
locus tag: YER150W
product: Spi1p
transcript id: NM_001179040.1
SIO_010081: YER150W
subclass of: SO_0000673
so part of: YER150W
location: <468370..>468816
location: region:468370-468816:1
so has part: feature:468370-468816:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:468370-468816:1:exon

YER150W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SPI1
locus tag: YER150W
experiment: EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9613572]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16980434]
note: GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication
codon start: 1
product: Spi1p
translation: MLSNAKLLLSLAMASTALGLVSNSSSSVIVVPSSDATIAGNDTATPAPEPSSAAPIFYNSTATATQYEVVSEFTTYCPEPTTFVTNGATFTVTAPTTLTITNCPCTIEKPTSETSVSSTHDVETNSNAANARAIPGALGLAGAVMMLL
SIO_010081: YER150W
subclass of: SO_0000673
so part of: YER150W
location: 468370..468816
location: region:468370-468816:1
so has part: feature:468370-468816:1:exon

NP_011077.1
type: Protein
SIO_000068: ncbiprotein

S000000952
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:468370-468816:1:exon

YNCE0026W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0026W
so part of: sequence
location: 469457..469530
location: region:469457-469530:1
so has part: feature:469457-469530:1:exon
subclass of: SO_0000663

856894
type: Gene
SIO_000068: ncbigene

position:469457:1
position: 469457
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:469530:1
position: 469530
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469457-469530:1:exon

YNCE0026W
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0026W
product: tRNA-Val
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Valine tRNA (tRNA-Val), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0026W
subclass of: SO_0000673
so part of: YNCE0026W
location: 469457..469530
location: region:469457-469530:1
so has part: feature:469457-469530:1:exon

S000006754
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469457-469530:1:exon

YER151C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: BLM3
gene: UBP3
locus tag: YER151C
gene synonym: BLM3
so part of: sequence
location: complement(<469686..>472424)
location: region:469686-472424:-1
so has part: feature:469686-472424:-1:exon
subclass of: SO_0000010

856895
type: Gene
SIO_000068: ncbigene

position:469686:-1
position: 469686
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:472424:-1
position: 472424
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:469686-472424:-1:exon

YER151C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: BLM3
gene: UBP3
locus tag: YER151C
gene synonym: BLM3
product: mRNA-binding ubiquitin-specific protease UBP3
transcript id: NM_001179041.3
SIO_010081: YER151C
subclass of: SO_0000673
so part of: YER151C
location: complement(<469686..>472424)
location: region:469686-472424:-1
so has part: feature:469686-472424:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:469686-472424:-1:exon

YER151C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: BLM3
gene: UBP3
locus tag: YER151C
gene synonym: BLM3
EC number: 3.4.19.12
experiment: EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764|PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:18498751]
experiment: EXISTENCE:genetic interaction:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]
experiment: EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:23476013]
experiment: EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:18498751|PMID:23476013|PMID:23645675]
experiment: EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:18391941]
experiment: EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]
experiment: EXISTENCE:mutant phenotype:GO:0047484 regulation of response to osmotic stress [PMID:21743437]
experiment: EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:12778054]
experiment: EXISTENCE:physical interaction:GO:0047484 regulation of response to osmotic stress [PMID:21743437]
experiment: EXISTENCE:physical interaction:GO:1990861 Ubp3-Bre5 deubiquitination complex [PMID:12778054]
note: Ubiquitin-specific protease that cleaves Ub-protein fusions; interacts with cofactor Bre5p to regulate transport between ER and Golgi, deubiquitinating COPII and COPI proteins, Sec23p and Sec27p; mediates steady-state retention of Golgi membrane proteins with Bre5p; phosphorylation (S695) by Hog1p regulates transcriptional activation by osmostress; inhibits Ras/PKA signaling through Ira2p; inhibits silencing; role in ribophagy; protein abundance increases in response to DNA replication stress
codon start: 1
product: mRNA-binding ubiquitin-specific protease UBP3
translation: MNMQDANKEESYSMYPKTSSPPPPTPTNMQIPIYQAPLQMYGYTQAPYLYPTQIPAYSFNMVNQNQPIYHQSGSPHHLPPQNNINGGSTTNNNNINKKKWHSNGITNNNGSSGNQGANSSGSGMSYNKSHTYHHNYSNNHIPMMASPNSGSNAGMKKQTNSSNGNGSSATSPSYSSYNSSSQYDLYKFDVTKLKNLKENSSNLIQLPLFINTTEAEFAAASVQRYELNMKALNLNSESLENSSVEKSSAHHHTKSHSIPKHNEEVKTETHGEEEDAHDKKPHASKDAHELKKKTEVKKEDAKQDRNEKVIQEPQATVLPVVDKKEPEESVEENTSKTSSPSPSPPAAKSWSAIASDAIKSRQASNKTVSGSMVTKTPISGTTAGVSSTNMAAATIGKSSSPLLSKQPQKKDKKYVPPSTKGIEPLGSIALRMCFDPDFISYVLRNKDVENKIPVHSIIPRGIINRANICFMSSVLQVLLYCKPFIDVINVLSTRNTNSRVGTSSCKLLDACLTMYKQFDKETYEKKFLENADDAEKTTESDAKKSSKSKSFQHCATADAVKPDEFYKTLSTIPKFKDLQWGHQEDAEEFLTHLLDQLHEELISAIDGLTDNEIQNMLQSINDEQLKVFFIRNLSRYGKAEFIKNASPRLKELIEKYGVINDDSTEENGWHEVSGSSKRGKKTKTAAKRTVEIVPSPISKLFGGQFRSVLDIPNNKESQSITLDPFQTIQLDISDAGVNDLETAFKKFSEYELLPFKSSSGNDVEAKKQTFIDKLPQVLLIQFKRFSFINNVNKDNAMTNYNAYNGRIEKIRKKIKYGHELIIPEESMSSITLKNNTSGIDDRRYKLTGVIYHHGVSSDGGHYTADVYHSEHNKWYRIDDVNITELEDDDVLKGGEEASDSRTAYILMYQKRN
SIO_010081: YER151C
subclass of: SO_0000673
so part of: YER151C
location: complement(469686..472424)
location: region:469686-472424:-1
so has part: feature:469686-472424:-1:exon

NP_011078.3
type: Protein
SIO_000068: ncbiprotein

S000000953
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:469686-472424:-1:exon

YER152C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER152C
so part of: sequence
location: complement(<472657..>473988)
location: region:472657-473988:-1
so has part: feature:472657-473988:-1:exon
subclass of: SO_0000010

856896
type: Gene
SIO_000068: ncbigene

position:472657:-1
position: 472657
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:473988:-1
position: 473988
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:472657-473988:-1:exon

YER152C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER152C
product: 2-aminoadipate transaminase
transcript id: NM_001179042.3
SIO_010081: YER152C
subclass of: SO_0000673
so part of: YER152C
location: complement(<472657..>473988)
location: region:472657-473988:-1
so has part: feature:472657-473988:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:472657-473988:-1:exon

YER152C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER152C
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]
note: Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
codon start: 1
product: 2-aminoadipate transaminase
translation: MKYKEINFFKGHPSSRLLPREAVIQATAAILGPETREYDNDPYNRHPLTYGSDEGALWVREQICTFLNDQLFKFENGARSRTRADYLNLNSGASYGMLNILLQTTLPHNGYTRQAFIITPTYFLINNCFTDAGFKGKMTAINEQGHDSIDFESLISALEQHEAEPQPHSTTEMIQGPKLTKKVYRYVMYCIPTFANPSGNTYSLETRRRLIDIARKYDMLIITDDVYDILDYTTPSDELPSPPLRMVHIDRSTAPSGEDSFGNTVSNATFSKLIAPGLRFGYHESINANLARQLSKGGANVSGGTPSQLNSMIVGEMLRSGAAQRCIAHLRSVYSERATVLTSALKKYMPLGTEIMPLKGGYFTWITLPPAYNAMEISTILAKKFNVILADGSNFEVIGDEKNWGQSCFRLSISFLEVDDIDRGIELFGAVCKSHAITNNITM
SIO_010081: YER152C
subclass of: SO_0000673
so part of: YER152C
location: complement(472657..473988)
location: region:472657-473988:-1
so has part: feature:472657-473988:-1:exon

NP_011079.3
type: Protein
SIO_000068: ncbiprotein

S000000954
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:472657-473988:-1:exon

YER153C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PET122
locus tag: YER153C
so part of: sequence
location: complement(<474041..>474805)
location: region:474041-474805:-1
so has part: feature:474041-474805:-1:exon
subclass of: SO_0000010

856897
type: Gene
SIO_000068: ncbigene

position:474041:-1
position: 474041
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:474805:-1
position: 474805
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:474041-474805:-1:exon

YER153C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PET122
locus tag: YER153C
product: Pet122p
transcript id: NM_001179043.1
SIO_010081: YER153C
subclass of: SO_0000673
so part of: YER153C
location: complement(<474041..>474805)
location: region:474041-474805:-1
so has part: feature:474041-474805:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:474041-474805:-1:exon

YER153C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PET122
locus tag: YER153C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12529447|PMID:8389363]
experiment: EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:2833749]
experiment: EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:2833749]
experiment: EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:2833749]
note: Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
codon start: 1
product: Pet122p
translation: MLTITKRLVTTDVRSRILLSSLNGKMSDALALLRQQQQTSVDVELLHTMLARAAALAHADTIAYMWYQHVMPRRLPVEGRLLCEMAGVALYQDRLFLPAQFLQHYQAMNRDRRTSPEDELIEYELRRIKVEAFARGTMHSTALREKWKVFLQEMDTLPGQPPLRLRDFPQMTKAMGIALMQQDEQAAALALFGRQPLVIKNEWSLPLLLAGVLWHVPGPAQARRVLAEFRQSYRGLPLLDAELVIKRRGFEINT
SIO_010081: YER153C
subclass of: SO_0000673
so part of: YER153C
location: complement(474041..474805)
location: region:474041-474805:-1
so has part: feature:474041-474805:-1:exon

NP_011080.1
type: Protein
SIO_000068: ncbiprotein

S000000955
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:474041-474805:-1:exon

YER154W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: OXA1
locus tag: YER154W
so part of: sequence
location: <475020..>476228
location: region:475020-476228:1
so has part: feature:475020-476228:1:exon
subclass of: SO_0000010

856898
type: Gene
SIO_000068: ncbigene

position:475020:1
position: 475020
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:476228:1
position: 476228
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:475020-476228:1:exon

YER154W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: OXA1
locus tag: YER154W
product: membrane insertase OXA1
transcript id: NM_001179044.1
SIO_010081: YER154W
subclass of: SO_0000673
so part of: YER154W
location: <475020..>476228
location: region:475020-476228:1
so has part: feature:475020-476228:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:475020-476228:1:exon

YER154W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: OXA1
locus tag: YER154W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:22513091]
experiment: EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:22513091]
experiment: EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:14657018]
experiment: EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:9285818|PMID:9428747]
experiment: EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:17452441|PMID:9285818|PMID:9428747|PMID:9482871]
experiment: EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:17344477]
experiment: EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:22846909]
note: Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals
codon start: 1
product: membrane insertase OXA1
translation: MFKLTSRLVTSRFAASSRLATARTIVLPRPHPSWISFQAKRFNSTGPNANDVSEIQTQLPSIDELTSSAPSLSASTSDLIANTTQTVGELSSHIGYLNSIGLAQTWYWPSDIIQHVLEAVHVYSGLPWWGTIAATTILIRCLMFPLYVKSSDTVARNSHIKPELDALNNKLMSTTDLQQGQLVAMQRKKLLSSHGIKNRWLAAPMLQIPIALGFFNALRHMANYPVDGFANQGVAWFTDLTQADPYLGLQVITAAVFISFTRLGGETGAQQFSSPMKRLFTILPIISIPATMNLSSAVVLYFAFNGAFSVLQTMILRNKWVRSKLKITEVAKPRTPIAGASPTENMGIFQSLKHNIQKARDQAERRQLMQDNEKKLQESFKEKRQNSKIKIVHKSNFINNKK
SIO_010081: YER154W
subclass of: SO_0000673
so part of: YER154W
location: 475020..476228
location: region:475020-476228:1
so has part: feature:475020-476228:1:exon

NP_011081.1
type: Protein
SIO_000068: ncbiprotein

S000000956
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:475020-476228:1:exon

YER155C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: IPL2
alternative label: SUP9
alternative label: TSL1
gene: BEM2
locus tag: YER155C
gene synonym: IPL2; SUP9; TSL1
so part of: sequence
location: complement(<476345..>482848)
location: region:476345-482848:-1
so has part: feature:476345-482848:-1:exon
subclass of: SO_0000010

856899
type: Gene
SIO_000068: ncbigene

position:476345:-1
position: 476345
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:482848:-1
position: 482848
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:476345-482848:-1:exon

YER155C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: IPL2
alternative label: SUP9
alternative label: TSL1
gene: BEM2
locus tag: YER155C
gene synonym: IPL2; SUP9; TSL1
product: GTPase-activating protein BEM2
transcript id: NM_001179045.3
SIO_010081: YER155C
subclass of: SO_0000673
so part of: YER155C
location: complement(<476345..>482848)
location: region:476345-482848:-1
so has part: feature:476345-482848:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:476345-482848:-1:exon

YER155C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: IPL2
alternative label: SUP9
alternative label: TSL1
gene: BEM2
locus tag: YER155C
gene synonym: IPL2; SUP9; TSL1
experiment: EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17914457]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:7962098|PMID:12145202]
experiment: EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17914457]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17914457]
experiment: EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17914457]
experiment: EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:17914457]
experiment: EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:17914457]
experiment: EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]
experiment: EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:12145202]
experiment: EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:7579704]
experiment: EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]
experiment: EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:12145202]
note: Rho GTPase activating protein (RhoGAP); contains RhoGAP activity specific for both Rho1p and Cdc42p, and potentially Rho4p; acts with the RhoGAP Bem3p to negatively regulate Cdc42p-dependent signal transduction; involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence and for the morphogenesis checkpoint in response to actin depolymerization; localizes to sites of polarized growth and the plasma membrane
codon start: 1
product: GTPase-activating protein BEM2
translation: MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQTIRNSTSGASPYMHSHHHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIASTLKDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGTTLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSENYDTTVFKTGWVNKSHGQTVATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGNDVASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANENHQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSEVYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFPLLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVFPGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSSTHELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNPLVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWLAVATIICSIPVLRSSSWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPNLDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHKTNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRSALVTGSYLPILFNELFPNYSLFPKNTLVGAASDAKLPPPRSSARLSKSLSISEPIPIASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNIDMDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLDTTGRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDTKDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTVLENMAKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDENINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIANSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFNTFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWIVLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNGTESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKNGSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGTQNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSITNSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAALHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIELRGLDEVG…
SIO_010081: YER155C
subclass of: SO_0000673
so part of: YER155C
location: complement(476345..482848)
location: region:476345-482848:-1
so has part: feature:476345-482848:-1:exon

NP_011082.3
type: Protein
SIO_000068: ncbiprotein

S000000957
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:476345-482848:-1:exon

YER156C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: MYG1
locus tag: YER156C
so part of: sequence
location: complement(<483325..>484341)
location: region:483325-484341:-1
so has part: feature:483325-484341:-1:exon
subclass of: SO_0000010

856900
type: Gene
SIO_000068: ncbigene

position:483325:-1
position: 483325
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:484341:-1
position: 484341
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:483325-484341:-1:exon

YER156C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: MYG1
locus tag: YER156C
product: Myg1p
transcript id: NM_001179046.3
SIO_010081: YER156C
subclass of: SO_0000673
so part of: YER156C
location: complement(<483325..>484341)
location: region:483325-484341:-1
so has part: feature:483325-484341:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:483325-484341:-1:exon

YER156C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: MYG1
locus tag: YER156C
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31323700]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:31323700]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:mutant phenotype:GO:1901857 positive regulation of cellular respiration [PMID:31081026]
note: Protein involved in mitochondrial function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; human homolog MYG1 is linked to developmental processes and dermatological diseases, complements yeast null mutant
codon start: 1
product: Myg1p
translation: MNSVKRVKLNSKMSKQICTHSGSFHADESLAVYMLRLLPEFKDAKLVRSRNPKDWEASDILVDVGAQYDGVKFFDHHQRGFFETFNEKYKTKLSSAGLIFKHYGRDIIKTILNNKVSSSDLDLLYDKVYKQFVEALDANDNGISKYTIPKDSNLEPNFRDNAISIPGIISGMNPNWNEDTSDESFDRCFARASEFIGGVFVTLVRGYGQSWLPAKALVAQAIDERMDVDKSGKIIVLPQFCPWKEHLYELEREKNIEKQIEFVLFTDSSGAWRVSTVPINSTSFQFRRGLPEPLRGLRDEELSTKSGVPGCIFIHAAGFIGGAKSKEAVYELAKMSLA
SIO_010081: YER156C
subclass of: SO_0000673
so part of: YER156C
location: complement(483325..484341)
location: region:483325-484341:-1
so has part: feature:483325-484341:-1:exon

NP_011083.3
type: Protein
SIO_000068: ncbiprotein

S000000958
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:483325-484341:-1:exon

YER157W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: GRD20
alternative label: SEC34
gene: COG3
locus tag: YER157W
gene synonym: GRD20; SEC34
so part of: sequence
location: <484788..>487193
location: region:484788-487193:1
so has part: feature:484788-487193:1:exon
subclass of: SO_0000010

856901
type: Gene
SIO_000068: ncbigene

position:484788:1
position: 484788
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:487193:1
position: 487193
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:484788-487193:1:exon

YER157W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: GRD20
alternative label: SEC34
gene: COG3
locus tag: YER157W
gene synonym: GRD20; SEC34
product: Golgi transport complex subunit COG3
transcript id: NM_001179047.1
SIO_010081: YER157W
subclass of: SO_0000673
so part of: YER157W
location: <484788..>487193
location: region:484788-487193:1
so has part: feature:484788-487193:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:484788-487193:1:exon

YER157W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: GRD20
alternative label: SEC34
gene: COG3
locus tag: YER157W
gene synonym: GRD20; SEC34
experiment: EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10512869]
experiment: EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20065092]
experiment: EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]
experiment: EXISTENCE:mutant phenotype:GO:0030242 autophagy of peroxisome [PMID:20065092]
experiment: EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:20065092]
experiment: EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:15229219]
note: Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
codon start: 1
product: Golgi transport complex subunit COG3
translation: MARSRKNSLVRDIASHPTIPESQTIVGLLDDSYLFDKLKKLSLAVENSDSLQRTDVSEGCSEVNGSEATTSADVKKTNKYLYYTTYLDQLNIKIDEYKVVLDQTRQVNDQLDSSIKKFRKISQDTGAFIEETKTIYEKQSKLSNLTESIPKALHYFEVLDPIMRRLNHATSPAIVKKSSFTTMLATIDESLRFLDENSDLKDAAAYRIKFKQCLIRACELISHFLTNLLKQTNQEILDKTKNKNSLTGLPSTTRDAFLYSKFYTIADTFKIQVSEIVKRSNEKAYNKYHDELNSILYECFNHYFQTRLRLLTPVIWSHIDEIVVKDKDQGLVKFIQDGKVYFQQLCADEYKLFVEFFPEKECRFKINQWFLQLCEPLYDSIRVRVLKETDICTLCDSVTLFAPYYEFEEGSEEYVKQFTDIQYDKLFEPIVQKVQARLILRVQIYVQQNILSYRPTRDVFMISNRRRKSKTSLQGGNEDATTSDDNPDPLLESYLSSFKNRSILPISPNDADDKSIDSEESTDKISQLQTYYPPLLKTLALLSKIYEMINSVVFDDLAHHVVHDCIVSLRNAYDMVIKSSAGKSDFNNLDISLAYLKNLLMLRDSIQNFNIQYTVNETYLDFSGVEGFFKSLKENGRNVLKKTKSSSILTLARELVPKVVNNMVDARTELISELRNVIKDFTESTSLELIDDTLDINSDEDLLSKNVKLRENIKARLPRIYEQILNYIDDQEIVTNLLDAVQELITQSYSKYYETITELAENGKFAKDQVADVMYLDVFTDFFAKEVADLLRNGDIDTITK
SIO_010081: YER157W
subclass of: SO_0000673
so part of: YER157W
location: 484788..487193
location: region:484788-487193:1
so has part: feature:484788-487193:1:exon

NP_011084.1
type: Protein
SIO_000068: ncbiprotein

S000000959
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:484788-487193:1:exon

YNCE0027C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0027C
so part of: sequence
location: complement(487331..487402)
location: region:487331-487402:-1
so has part: feature:487331-487402:-1:exon
subclass of: SO_0000663

856902
type: Gene
SIO_000068: ncbigene

position:487331:-1
position: 487331
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:487402:-1
position: 487402
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487331-487402:-1:exon

YNCE0027C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0027C
product: tRNA-Glu
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Glutamate tRNA (tRNA-Glu), predicted by tRNAscan-SE analysis; thiolation of uridine at wobble position (34) requires Ncs6p; target of K. lactis zymocin
SIO_010081: YNCE0027C
subclass of: SO_0000673
so part of: YNCE0027C
location: complement(487331..487402)
location: region:487331-487402:-1
so has part: feature:487331-487402:-1:exon

S000006552
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:487331-487402:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 487834..488165
location: region:487834-488165:1
so has part: feature:487834-488165:1:region

S000006920
type: SGD
SIO_000068: sgd

position:487834:1
position: 487834
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:488165:1
position: 488165
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:487834-488165:1:region

YER158C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER158C
so part of: sequence
location: complement(<488857..>490578)
location: region:488857-490578:-1
so has part: feature:488857-490578:-1:exon
subclass of: SO_0000010

856903
type: Gene
SIO_000068: ncbigene

position:488857:-1
position: 488857
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:490578:-1
position: 490578
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:488857-490578:-1:exon

YER158C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER158C
product: uncharacterized protein
transcript id: NM_001179048.1
SIO_010081: YER158C
subclass of: SO_0000673
so part of: YER158C
location: complement(<488857..>490578)
location: region:488857-490578:-1
so has part: feature:488857-490578:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:488857-490578:-1:exon

YER158C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER158C
note: hypothetical protein; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication
codon start: 1
product: uncharacterized protein
translation: MLQQGSSSRRSLHGNDFHTLTSPSRRDSLSIPRAVDARSASTIDLFYIPDATVSRRHSTLVANRSDNNGNGAPMRQYNKPNFASSSTSSLPSTRNRPSRYDNMNMNMNMNMNMNMNMNMNMNNHTTSDHNAHPQYRCRPNPSRRHSLMTIPEKYSGSRYSLRSSPPTYSNPRVRKELTPFQLQRKQMKSAFQFPNGENFTPRNQIARLPPSSTFPDSPSSSSLPLTQTGGPSSADNDSIATGTNNRSPQQTKAADANQKSESESPKAIRSNSKKISRFFRKIWSSKSSNSADSVEENSKTKQKRKNPERVVPEPITSLDQPVEIIKQSFSTVNNHETAVPSIKDSGIVQELTALGDNNRIPVLPPPRSPNRPTLSDKRTTKLYYCSQDSSNEDIAPEEKSTVFLKRLQDEWSTVYLNKLPLTASVPSSLSTTTDAANSSFINSSISSPAPSSSSSSSLVSRGPMQSISSSPTPAPSSGSSKSKNAVKSLRFADEIYVNDTWSAADYCRCDNTFLNNFFKGKSQDITNPSTFVGNNLSSTKNISNIEIKMEVNEFKRKEMRVHQDSAKYTHYYL
SIO_010081: YER158C
subclass of: SO_0000673
so part of: YER158C
location: complement(488857..490578)
location: region:488857-490578:-1
so has part: feature:488857-490578:-1:exon

NP_011085.1
type: Protein
SIO_000068: ncbiprotein

S000000960
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:488857-490578:-1:exon

YER159C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: NCB1
gene: BUR6
locus tag: YER159C
gene synonym: NCB1
so part of: sequence
location: complement(<491530..>491958)
location: region:491530-491958:-1
so has part: feature:491530-491958:-1:exon
subclass of: SO_0000010

856904
type: Gene
SIO_000068: ncbigene

position:491530:-1
position: 491530
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:491958:-1
position: 491958
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:491530-491958:-1:exon

YER159C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: NCB1
gene: BUR6
locus tag: YER159C
gene synonym: NCB1
product: negative cofactor 2 transcription regulator complex subunit BUR6
transcript id: NM_001179049.3
SIO_010081: YER159C
subclass of: SO_0000673
so part of: YER159C
location: complement(<491530..>491958)
location: region:491530-491958:-1
so has part: feature:491530-491958:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:491530-491958:-1:exon

YER159C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: NCB1
gene: BUR6
locus tag: YER159C
gene synonym: NCB1
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8948634|PMID:9023340|PMID:9096360]
experiment: EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:18703679]
experiment: EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18703679]
experiment: EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:12237409]
experiment: EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9023340]
experiment: EXISTENCE:direct assay:GO:0017054 negative cofactor 2 complex [PMID:8948634]
experiment: EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12237409]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10713169]
experiment: EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:10713169]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10713169]
experiment: EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:10713169]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18048413]
experiment: EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:18048413]
experiment: EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:9096360]
experiment: EXISTENCE:physical interaction:GO:0017054 negative cofactor 2 complex [PMID:9023340]
note: Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1
codon start: 1
product: negative cofactor 2 transcription regulator complex subunit BUR6
translation: MADQVPVTTQLPPIKPEHEVPLDAGGSPVGNMGTNSNNNNELGDVFDRIKTHFPPAKVKKIMQTDEDIGKVSQATPVIAGRSLEFFIALLVKKSGEMARGQGTKRITAEILKKTILNDEKFDFLREGLCVEEGQTQPEEESA
SIO_010081: YER159C
subclass of: SO_0000673
so part of: YER159C
location: complement(491530..491958)
location: region:491530-491958:-1
so has part: feature:491530-491958:-1:exon

NP_011086.3
type: Protein
SIO_000068: ncbiprotein

S000000961
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:491530-491958:-1:exon

YNCE0028C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0028C
so part of: sequence
location: complement(492352..492424)
location: region:492352-492424:-1
so has part: feature:492352-492424:-1:exon
subclass of: SO_0000663

856905
type: Gene
SIO_000068: ncbigene

position:492352:-1
position: 492352
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:492424:-1
position: 492424
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492352-492424:-1:exon

YNCE0028C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0028C
product: tRNA-Arg
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Arginine tRNA (tRNA-Arg), predicted by tRNAscan-SE analysis; one of 6 nuclear tRNA genes containing the tDNA-anticodon ACG (converted to ICG in the mature tRNA), decodes CGU, CGC, and probably CGA codons into arginine, one of 19 nuclear tRNAs for arginine
SIO_010081: YNCE0028C
subclass of: SO_0000673
so part of: YNCE0028C
location: complement(492352..492424)
location: region:492352-492424:-1
so has part: feature:492352-492424:-1:exon

S000006701
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:492352-492424:-1:exon

mobile_element
type: Mobile Element
subclass of: SO_0001037
RO_0002162: 559292
note: YERCTy1-2; Ty1 element, LTR retrotransposon of the Copia (Pseudoviridae) group; contains co-transcribed genes TYA Gag and TYB Pol, encoding proteins involved in structure and function of virus-like particles, flanked by two direct repeats
mobile element type: retrotransposon:YERCTy1-2
so part of: sequence
location: complement(492695..498421)
location: region:492695-498421:-1
so has part: feature:492695-498421:-1:region

S000006911
type: SGD
SIO_000068: sgd

position:492695:-1
position: 492695
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:498421:-1
position: 498421
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492695-498421:-1:region

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(492695..492833)
location: region:492695-492833:-1
so has part: feature:492695-492833:-1:region

S000006900
type: SGD
SIO_000068: sgd

position:492833:-1
position: 492833
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492695-492833:-1:region

YER160C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER160C
so part of: sequence
location: complement(<492856..>498124)
location: region:492856-498124:-1
so has part: feature:492856-498124:-1:exon
subclass of: SO_0000010

856906
type: Gene
SIO_000068: ncbigene

position:492856:-1
position: 492856
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:498124:-1
position: 498124
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:492856-498124:-1:exon

YER160C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER160C
product: gag-pol fusion protein
transcript id: NM_001179050.4
SIO_010081: YER160C
subclass of: SO_0000673
so part of: YER160C
location: complement(<492856..>498124)
location: region:492856-498124:-1
so has part: feature:492856-498124:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:492856-498124:-1:exon

YER160C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER160C
EC number: 2.7.7.7
EC number: 2.7.7.49
EC number: 3.1.26.4
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]
ribosomal slippage: true
note: Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes
codon start: 1
product: gag-pol fusion protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHLLLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVLHTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNISVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDYQCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDETTKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKNGITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLASPKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSNDLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVDPNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDFRHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLHHVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGIGDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSIKPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVINSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYITQLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQCGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYELIQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKSTKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNNEEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH
SIO_010081: YER160C
subclass of: SO_0000673
so part of: YER160C
location: complement(join(492856..496821,496823..498124))
location: region:492856-498124:-1
so has part: feature:496823-498124:-1:exon
so has part: feature:492856-496821:-1:exon

NP_011087.3
type: Protein
SIO_000068: ncbiprotein

S000000962
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:496823-498124:-1:exon

position:496823:-1
position: 496823
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:492856-496821:-1:exon

position:496821:-1
position: 496821
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

YER159C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER159C-A
so part of: sequence
location: complement(<496802..>498124)
location: region:496802-498124:-1
so has part: feature:496802-498124:-1:exon
subclass of: SO_0000010

856907
type: Gene
SIO_000068: ncbigene

position:496802:-1
position: 496802
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:496802-498124:-1:exon

YER159C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER159C-A
product: gag protein
transcript id: NM_001184429.1
SIO_010081: YER159C-A
subclass of: SO_0000673
so part of: YER159C-A
location: complement(<496802..>498124)
location: region:496802-498124:-1
so has part: feature:496802-498124:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:496802-498124:-1:exon

YER159C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER159C-A
note: Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
codon start: 1
product: gag protein
translation: MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY
SIO_010081: YER159C-A
subclass of: SO_0000673
so part of: YER159C-A
location: complement(496802..498124)
location: region:496802-498124:-1
so has part: feature:496802-498124:-1:exon

NP_058156.1
type: Protein
SIO_000068: ncbiprotein

S000007403
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:496802-498124:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(498084..498421)
location: region:498084-498421:-1
so has part: feature:498084-498421:-1:region

S000006901
type: SGD
SIO_000068: sgd

position:498084:-1
position: 498084
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498084-498421:-1:region

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS520; Autonomously Replicating Sequence
so part of: sequence
location: 498884..499182
location: region:498884-499182:1
so has part: feature:498884-499182:1:region

S000077392
type: SGD
SIO_000068: sgd

position:498884:1
position: 498884
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:499182:1
position: 499182
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:498884-499182:1:region

YER161C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: EXA1
alternative label: SIN1
gene: SPT2
locus tag: YER161C
gene synonym: EXA1; SIN1
so part of: sequence
location: complement(<499347..>500348)
location: region:499347-500348:-1
so has part: feature:499347-500348:-1:exon
subclass of: SO_0000010

856908
type: Gene
SIO_000068: ncbigene

position:499347:-1
position: 499347
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:500348:-1
position: 500348
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:499347-500348:-1:exon

YER161C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: EXA1
alternative label: SIN1
gene: SPT2
locus tag: YER161C
gene synonym: EXA1; SIN1
product: Spt2p
transcript id: NM_001179051.1
SIO_010081: YER161C
subclass of: SO_0000673
so part of: YER161C
location: complement(<499347..>500348)
location: region:499347-500348:-1
so has part: feature:499347-500348:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:499347-500348:-1:exon

YER161C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: EXA1
alternative label: SIN1
gene: SPT2
locus tag: YER161C
gene synonym: EXA1; SIN1
experiment: EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:15563464]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:2072912]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2072912|PMID:22932476]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:16449659]
experiment: EXISTENCE:genetic interaction:GO:0043631 RNA polyadenylation [PMID:16788068]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]
experiment: EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:16449659|PMID:19057669]
experiment: EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:26109053]
experiment: EXISTENCE:mutant phenotype:GO:0043631 RNA polyadenylation [PMID:16788068]
experiment: EXISTENCE:mutant phenotype:GO:0140713 histone chaperone activity [PMID:26109053]
note: Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins
codon start: 1
product: Spt2p
translation: MSFLSKLSQIRKSTTASKAQVQDPLPKKNDEEYSLLPKNYIRDEDPAVKRLKELRRQELLKNGALAKKSGVKRKRGTSSGSEKKKIERNDDDEGGLGIRFKRSIGASHAPLKPVVRKKPEPIKKMSFEELMKQAENNEKQPPKVKSSEPVTKERPHFNKPGFKSSKRPQKKASPGATLRGVSSGGNSIKSSDSPKPVKLNLPTNGFAQPNRRLKEKLESRKQKSRYQDDYDEEDNDMDDFIEDDEDEGYHSKSKHSNGPGYDRDEIWAMFNRGKKRSEYDYDELEDDDMEANEMEILEEEEMARKMARLEDKREEAWLKKHEEEKRRRKKGIR
SIO_010081: YER161C
subclass of: SO_0000673
so part of: YER161C
location: complement(499347..500348)
location: region:499347-500348:-1
so has part: feature:499347-500348:-1:exon

NP_011088.1
type: Protein
SIO_000068: ncbiprotein

S000000963
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:499347-500348:-1:exon

YER162C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD4
locus tag: YER162C
so part of: sequence
location: complement(<500630..>502894)
location: region:500630-502894:-1
so has part: feature:500630-502894:-1:exon
subclass of: SO_0000010

856909
type: Gene
SIO_000068: ncbigene

position:500630:-1
position: 500630
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:502894:-1
position: 502894
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:500630-502894:-1:exon

YER162C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD4
locus tag: YER162C
product: Rad4p
transcript id: NM_001179052.4
SIO_010081: YER162C
subclass of: SO_0000673
so part of: YER162C
location: complement(<500630..>502894)
location: region:500630-502894:-1
so has part: feature:500630-502894:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:500630-502894:-1:exon

YER162C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD4
locus tag: YER162C
experiment: EXISTENCE:direct assay:GO:0000111 nucleotide-excision repair factor 2 complex [PMID:7768886]
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9813069|PMID:9837874]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19889839]
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19889839]
experiment: EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:27035942]
experiment: EXISTENCE:direct assay:GO:1990165 single-strand break-containing DNA binding [PMID:27035942]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26150418]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:18936173]
experiment: EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19889839]
note: Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol
codon start: 1
product: Rad4p
translation: MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKKKFKTGLNELPRESVVTVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTDGNEVAGVEDISVEIKPSSKRNSDARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWINSKRLSRKLSNLVPEKVFELLHPQKDEELPLRSTRKLLDGLKKCMELWQKHWKITKKYDNVGLYMRTWKEIEMSANNKRKFKTLKRSDFLRAVSKGHGDPDISVQGFVAMLRACNVNARLIMSCQPPDFTNMKIDTSLNGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPKGVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEKWFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPGCKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNGRILKTGSRCKKVIKRTVGRPKGEAEEEDERLYSFEDTELYIPPLASASGEITKNTFGNIEVFAPTMIPGNCCLVENPVAIKAARFLGVEFAPAVTSFKFERGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWNTLLLKLRIRSKLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMGGGFLPGIANHEARPYSEPSEPEDSLDYVSVDKAEESATDDDVGEDYSDFMKELEMSEESD
SIO_010081: YER162C
subclass of: SO_0000673
so part of: YER162C
location: complement(500630..502894)
location: region:500630-502894:-1
so has part: feature:500630-502894:-1:exon

NP_011089.4
type: Protein
SIO_000068: ncbiprotein

S000000964
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:500630-502894:-1:exon

YER163C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GCG1
locus tag: YER163C
so part of: sequence
location: complement(<503084..>503782)
location: region:503084-503782:-1
so has part: feature:503084-503782:-1:exon
subclass of: SO_0000010

856910
type: Gene
SIO_000068: ncbigene

position:503084:-1
position: 503084
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:503782:-1
position: 503782
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:503084-503782:-1:exon

YER163C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GCG1
locus tag: YER163C
product: gamma-glutamylcyclotransferase
transcript id: NM_001179053.3
SIO_010081: YER163C
subclass of: SO_0000673
so part of: YER163C
location: complement(<503084..>503782)
location: region:503084-503782:-1
so has part: feature:503084-503782:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:503084-503782:-1:exon

YER163C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GCG1
locus tag: YER163C
EC number: 4.3.2.7
experiment: EXISTENCE:direct assay:GO:0003839 gamma-glutamylcyclotransferase activity [PMID:23070364]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:23070364]
experiment: EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:23070364]
note: Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle
codon start: 1
product: gamma-glutamylcyclotransferase
translation: MTNDNSGIWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYEDIIRQTAFLKNVNLYSESAPIQDPDDLVTIGVVYYIPPEHAQEVREYLNVREQNGYTLHEVEVHLETNREHEAELGEALEQLPRHNKSGKRVLLTSVYIGTIDNEAFVGPETVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPIMKERGRITDHYLTALLETVNKYR
SIO_010081: YER163C
subclass of: SO_0000673
so part of: YER163C
location: complement(503084..503782)
location: region:503084-503782:-1
so has part: feature:503084-503782:-1:exon

NP_011090.3
type: Protein
SIO_000068: ncbiprotein

S000000965
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:503084-503782:-1:exon

YER164W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: CHD1
locus tag: YER164W
so part of: sequence
location: <505392..>509798
location: region:505392-509798:1
so has part: feature:505392-509798:1:exon
subclass of: SO_0000010

856911
type: Gene
SIO_000068: ncbigene

position:505392:1
position: 505392
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:509798:1
position: 509798
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:505392-509798:1:exon

YER164W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: CHD1
locus tag: YER164W
product: chromatin-remodeling ATPase CHD1
transcript id: NM_001179054.1
SIO_010081: YER164W
subclass of: SO_0000673
so part of: YER164W
location: <505392..>509798
location: region:505392-509798:1
so has part: feature:505392-509798:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:505392-509798:1:exon

YER164W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: CHD1
locus tag: YER164W
experiment: EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:15647753]
experiment: EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:17259992]
experiment: EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12504018|PMID:12682017]
experiment: EXISTENCE:direct assay:GO:0000976 transcription cis-regulatory region binding [PMID:23468649]
experiment: EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:21623345]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:10811623|PMID:33174727]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10811623]
experiment: EXISTENCE:direct assay:GO:0030874 nucleolar chromatin [PMID:17259992]
experiment: EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:12682017]
experiment: EXISTENCE:direct assay:GO:0035064 methylated histone binding [PMID:15647753]
experiment: EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:15647753]
experiment: EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:10811623|PMID:33174727]
experiment: EXISTENCE:genetic interaction:GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter [PMID:19948887]
experiment: EXISTENCE:genetic interaction:GO:0006363 termination of RNA polymerase I transcription [PMID:17259992]
experiment: EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:12682017]
experiment: EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]
experiment: EXISTENCE:genetic interaction:GO:2000104 negative regulation of DNA-templated DNA replication [PMID:18245327]
experiment: EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]
experiment: EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:31222142]
experiment: EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:10811623]
experiment: EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:22922743]
experiment: EXISTENCE:physical interaction:GO:0006368 transcription elongation by RNA polymerase II promoter [PMID:12682017]
note: Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains chromo domain, helicase domain and DNA-binding domain; component of both SAGA and SLIK complexes; in human, deletion of CHD1 is a frequent event in prostate cancer
codon start: 1
product: chromatin-remodeling ATPase CHD1
translation: MAAKDISTEVLQNPELYGLRRSHRAAAHQQNYFNDSDDEDDEDNIKQSRRKRMTTIEDDEDEFEDEEGEEDSGEDEDEEDFEEDDDYYGSPIKQNRSKPKSRTKSKSKSKPKSQSEKQSTVKIPTRFSNRQNKTVNYNIDYSDDDLLESEDDYGSEEALSEENVHEASANPQPEDFHGIDIVINHRLKTSLEEGKVLEKTVPDLNNCKENYEFLIKWTDESHLHNTWETYESIGQVRGLKRLDNYCKQFIIEDQQVRLDPYVTAEDIEIMDMERERRLDEFEEFHVPERIIDSQRASLEDGTSQLQYLVKWRRLNYDEATWENATDIVKLAPEQVKHFQNRENSKILPQYSSNYTSQRPRFEKLSVQPPFIKGGELRDFQLTGINWMAFLWSKGDNGILADEMGLGKTVQTVAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDLNCICYMGNQKSRDTIREYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHRLKNAESSLYESLNSFKVANRMLITGTPLQNNIKELAALVNFLMPGRFTIDQEIDFENQDEEQEEYIHDLHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTKNYSALTAGAKGGHFSLLNIMNELKKASNHPYLFDNAEERVLQKFGDGKMTRENVLRGLIMSSGKMVLLDQLLTRLKKDGHRVLIFSQMVRMLDILGDYLSIKGINFQRLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGGLGINLMTADTVVIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILEYAIISLGVTDGNKYTKKNEPNAGELSAILKFGAGNMFTATDNQKKLEDLNLDDVLNHAEDHVTTPDLGESHLGGEEFLKQFEVTDYKADIDWDDIIPEEELKKLQDEEQKRKDEEYVKEQLEMMNRRDNALKKIKNSVNGDGTAANSDSDDDSTSRSSRRRARANDMDSIGESEVRALYKAILKFGNLKEILDELIADGTLPVKSFEKYGETYDEMMEAAKDCVHEEEKNRKEILEKLEKHATAYRAKLKSGEIKAENQPKDNPLTRLSLKKREKKAVLFNFKGVKSLNAESLLSRVEDLKYLKNLINSNYKDDPLKFSLGNNTPKPVQNWSSNWTKEEDEKLLIGVFKYGYGSWTQIRDDPFLGITDKIFLNEVHNPVAKKSASSSDTTPTPSKKGKGITGSSKKVPGAIHLGRRVDYLLSFLRGGLNTKSPSADIGSKKLPTGPSKKRQRKPANHSKSMTPEITSSEPANGPPSKRMKALPKGPAALINNTRLSPNSPTPPLKSKVSRDNGTRQSSNPSSGSAHEKEYDSMDEEDCRHTMSAIRTSLKRLRRGGKSLDRKEWAKILKTELTTIGNHIESQKGSSRKASPEKYRKHLWSYSANFWPADVKSTKLMAMYDKITESQKK
SIO_010081: YER164W
subclass of: SO_0000673
so part of: YER164W
location: 505392..509798
location: region:505392-509798:1
so has part: feature:505392-509798:1:exon

NP_011091.1
type: Protein
SIO_000068: ncbiprotein

S000000966
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:505392-509798:1:exon

YER165W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PAB1
locus tag: YER165W
so part of: sequence
location: <510373..>512106
location: region:510373-512106:1
so has part: feature:510373-512106:1:exon
subclass of: SO_0000010

856912
type: Gene
SIO_000068: ncbigene

position:510373:1
position: 510373
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:512106:1
position: 512106
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:510373-512106:1:exon

YER165W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PAB1
locus tag: YER165W
product: polyadenylate-binding protein
transcript id: NM_001179055.1
SIO_010081: YER165W
subclass of: SO_0000673
so part of: YER165W
location: <510373..>512106
location: region:510373-512106:1
so has part: feature:510373-512106:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:510373-512106:1:exon

YER165W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PAB1
locus tag: YER165W
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15630021|PMID:15769879|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15630021|PMID:15769879|PMID:11914276]
experiment: EXISTENCE:direct assay:GO:0005840 ribosome [PMID:8631901]
experiment: EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:10357826]
experiment: EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:9193001]
experiment: EXISTENCE:direct assay:GO:0008428 ribonuclease inhibitor activity [PMID:11889048]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:17908917|PMID:18981231|PMID:19470581|PMID:24291094|P MID:26777405]
experiment: EXISTENCE:direct assay:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:17766253]
experiment: EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]
experiment: EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:10357826]
experiment: EXISTENCE:mutant phenotype:GO:0008143 poly(A) binding [PMID:9193001]
experiment: EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:9223284]
experiment: EXISTENCE:mutant phenotype:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:17766253]
experiment: EXISTENCE:physical interaction:GO:0034236 protein kinase A catalytic subunit binding [PMID:22899713]
note: Poly(A) binding protein; interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex
codon start: 1
product: polyadenylate-binding protein
translation: MADITDKTAEQLENLNIQDDQKQAATGSESQSVENSSASLYVGDLEPSVSEAHLYDIFSPIGSVSSIRVCRDAITKTSLGYAYVNFNDHEAGRKAIEQLNYTPIKGRLCRIMWSQRDPSLRKKGSGNIFIKNLHPDIDNKALYDTFSVFGDILSSKIATDENGKSKGFGFVHFEEEGAAKEAIDALNGMLLNGQEIYVAPHLSRKERDSQLEETKAHYTNLYVKNINSETTDEQFQELFAKFGPIVSASLEKDADGKLKGFGFVNYEKHEDAVKAVEALNDSELNGEKLYVGRAQKKNERMHVLKKQYEAYRLEKMAKYQGVNLFVKNLDDSVDDEKLEEEFAPYGTITSAKVMRTENGKSKGFGFVCFSTPEEATKAITEKNQQIVAGKPLYVAIAQRKDVRRSQLAQQIQARNQMRYQQATAAAAAAAAGMPGQFMPPMFYGVMPPRGVPFNGPNPQQMNPMGGMPKNGMPPQFRNGPVYGVPPQGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITGMILDLPPQEVFPLLESDELFEQHYKEASAAYESFKKEQEQQTEQA
SIO_010081: YER165W
subclass of: SO_0000673
so part of: YER165W
location: 510373..512106
location: region:510373-512106:1
so has part: feature:510373-512106:1:exon

NP_011092.1
type: Protein
SIO_000068: ncbiprotein

S000000967
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:510373-512106:1:exon

YER166W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: DNF1
locus tag: YER166W
so part of: sequence
location: <512744..>517459
location: region:512744-517459:1
so has part: feature:512744-517459:1:exon
subclass of: SO_0000010

856913
type: Gene
SIO_000068: ncbigene

position:512744:1
position: 512744
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:517459:1
position: 517459
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:512744-517459:1:exon

YER166W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: DNF1
locus tag: YER166W
product: aminophospholipid-translocating P4-type ATPase DNF1
transcript id: NM_001179056.3
SIO_010081: YER166W
subclass of: SO_0000673
so part of: YER166W
location: <512744..>517459
location: region:512744-517459:1
so has part: feature:512744-517459:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:512744-517459:1:exon

YER166W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: DNF1
locus tag: YER166W
EC number: 7.6.2.1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12221123|PMID:12631737|PMID:33060204]
experiment: EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]
experiment: EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]
experiment: EXISTENCE:genetic interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:25378585]
experiment: EXISTENCE:genetic interaction:GO:0006886 intracellular protein transport [PMID:12221123]
experiment: EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12631737]
experiment: EXISTENCE:genetic interaction:GO:0007163 establishment or maintenance of cell polarity [PMID:15461661]
experiment: EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:genetic interaction:GO:0090555 phosphatidylethanolamine flippase activity [PMID:12631737|PMID:17015438]
experiment: EXISTENCE:genetic interaction:GO:0140345 phosphatidylcholine flippase activity [PMID:12631737]
experiment: EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12631737]
experiment: EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:17015438]
experiment: EXISTENCE:mutant phenotype:GO:0090555 phosphatidylethanolamine flippase activity [PMID:17015438|PMID:27432949]
experiment: EXISTENCE:mutant phenotype:GO:0099040 ceramide translocation [PMID:33060204]
experiment: EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:27432949]
experiment: EXISTENCE:mutant phenotype:GO:0140351 glycosylceramide flippase activity [PMID:33060204]
experiment: EXISTENCE:physical interaction:GO:1990531 phospholipid-translocating ATPase complex [PMID:15090616]
note: Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication
codon start: 1
product: aminophospholipid-translocating P4-type ATPase DNF1
translation: MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSNKYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN
SIO_010081: YER166W
subclass of: SO_0000673
so part of: YER166W
location: 512744..517459
location: region:512744-517459:1
so has part: feature:512744-517459:1:exon

NP_011093.3
type: Protein
SIO_000068: ncbiprotein

S000000968
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:512744-517459:1:exon

YER167W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: CTR7
gene: BCK2
locus tag: YER167W
gene synonym: CTR7
so part of: sequence
location: <518216..>520771
location: region:518216-520771:1
so has part: feature:518216-520771:1:exon
subclass of: SO_0000010

856914
type: Gene
SIO_000068: ncbigene

position:518216:1
position: 518216
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:520771:1
position: 520771
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:518216-520771:1:exon

YER167W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: CTR7
gene: BCK2
locus tag: YER167W
gene synonym: CTR7
product: Bck2p
transcript id: NM_001179057.3
SIO_010081: YER167W
subclass of: SO_0000673
so part of: YER167W
location: <518216..>520771
location: region:518216-520771:1
so has part: feature:518216-520771:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:518216-520771:1:exon

YER167W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: CTR7
gene: BCK2
locus tag: YER167W
gene synonym: CTR7
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]
experiment: EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]
experiment: EXISTENCE:mutant phenotype:GO:0010628 positive regulation of gene expression [PMID:19158491]
experiment: EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:7891677]
note: Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations
codon start: 1
product: Bck2p
translation: MPKNSHHHRSSSVNSTKSRSTESTNKWKIPHYYRRSASGSTQASPDRNSSTGSCSTPVLPTMNVMSSPKKVLLEDPRDNHTKAKKSSRKKSGEMVFVNYTVQDTANENDTDLQTQPVSVPAPKAKLKKKSSKRRMLKIFGSSKNEHIEDIVEEQPMVLQMDSESKPLSGTPISESGIDASSLTTKRSYNSFLKHNRLNGKTPFSGNLSFPSLNMMGNTTDLPIDNNDFCSEKEVVPKSTHDPSLAKPPSRFTESETNSTPNLSSIPLMNTKNTRLKYNKVAPQSSDRQKSQESGLYHSTESFNFKDQNYSNNKSSLSLNSDLSTPHFAKHSPDSPRTSRSFNCGDSQSKVKLPEENDASIAFSKMFTRKRANTGGSTCSLASPTIAQTIQQSNIKVNKLPTQRTTSVGSLSSMSNRYSPIRVASPGRARSATRGSSLYRLSRDLNSLPSVTDLPEMDSTTPVNEIFLDGQPQHKSGSVKGGHRKKQESISDAQRIQHSNSYITTPSSSLVTPPYYMTGYTLPSSASASSTPNVLETHNMNFVPSTSTVTSYRPSSNFSSFDKEYSNENDASGEFSAFNTPMENIPALKGIPRSTLEENEEEDVLVQDIPNTAHFQRRDIMGMDTHRKDDSLDFNSLMPHGSTTSSSIVDSVMTNSISTTTSNATGNYFQDQDKYTLVNTGLGLSDANLDHFIRSQWKHASRSESNNNTGNRVSYSGSTPNNVDTTKTNLQVYTEFDFENPESFFHEQSKLLGEMGHSNNNSNSAINMNEPKSADTYIGNISPDTSATVSLGDLMGSNVSNNSERNFYDGHTFVPQYQANSSVENSNNQNAAPIANNDIDNNLQSFYFDNSN
SIO_010081: YER167W
subclass of: SO_0000673
so part of: YER167W
location: 518216..520771
location: region:518216-520771:1
so has part: feature:518216-520771:1:exon

NP_011094.3
type: Protein
SIO_000068: ncbiprotein

S000000969
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:518216-520771:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS521; Autonomously Replicating Sequence
so part of: sequence
location: 520772..521030
location: region:520772-521030:1
so has part: feature:520772-521030:1:region

S000077393
type: SGD
SIO_000068: sgd

position:520772:1
position: 520772
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:521030:1
position: 521030
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:520772-521030:1:region

YER168C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TNT1
gene: CCA1
locus tag: YER168C
gene synonym: TNT1
so part of: sequence
location: complement(<521029..>522669)
location: region:521029-522669:-1
so has part: feature:521029-522669:-1:exon
subclass of: SO_0000010

856915
type: Gene
SIO_000068: ncbigene

position:521029:-1
position: 521029
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:522669:-1
position: 522669
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:521029-522669:-1:exon

YER168C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TNT1
gene: CCA1
locus tag: YER168C
gene synonym: TNT1
product: tRNA adenylyltransferase
transcript id: NM_001179058.1
SIO_010081: YER168C
subclass of: SO_0000673
so part of: YER168C
location: complement(<521029..>522669)
location: region:521029-522669:-1
so has part: feature:521029-522669:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:521029-522669:-1:exon

YER168C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TNT1
gene: CCA1
locus tag: YER168C
gene synonym: TNT1
EC number: 2.7.7.72
experiment: EXISTENCE:direct assay:GO:0001680 tRNA 3'-terminal CCA addition [PMID:1634528]
experiment: EXISTENCE:direct assay:GO:0004810 CCA tRNA nucleotidyltransferase [PMID:1634528]
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1634528]
experiment: EXISTENCE:direct assay:GO:0052927 CTP:tRNA cytidylyltransferase activity [PMID:23872483]
experiment: EXISTENCE:direct assay:GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [PMID:23872483]
note: ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant
codon start: 1
product: tRNA adenylyltransferase
translation: MLRSTISLLMNSAAQKTMTNSNFVLNAPKITLTKVEQNICNLLNDYTDLYNQKYHNKPEPLTLRITGGWVRDKLLGQGSHDLDIAINVMSGEQFATGLNEYLQQHYAKYGAKPHNIHKIDKNPEKSKHLETATTKLFGVEVDFVNLRSEKYTELSRIPKVCFGTPEEDALRRDATLNALFYNIHKGEVEDFTKRGLQDLKDGVLRTPLPAKQTFLDDPLRVLRLIRFASRFNFTIDPEVMAEMGDPQINVAFNSKISRERVGVEMEKILVGPTPLLALQLIQRAHLENVIFFWHNDSSVVKFNEENCQDMDKINHVYNDNILNSHLKSFIELYPMFLEKLPILREKIGRSPGFQQNFILSAILSPMANLQIIGNPKKKINNLVSVTESIVKEGLKLSKNDAAVIAKTVDSICSYEEILAKFADRSQLKKSEIGIFLRNFNGEWETAHFASLSDAFLKIPKLETKKIELLFQNYNEFYSYIFDNNLNNCHELKPIVDGKQMAKLLQMKPGPWLGKINNEAIRWQFDNPTGTDQELITHLKAILPKYL
SIO_010081: YER168C
subclass of: SO_0000673
so part of: YER168C
location: complement(521029..522669)
location: region:521029-522669:-1
so has part: feature:521029-522669:-1:exon

NP_011095.1
type: Protein
SIO_000068: ncbiprotein

S000000970
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:521029-522669:-1:exon

YER169W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: KDM4
gene: RPH1
locus tag: YER169W
gene synonym: KDM4
so part of: sequence
location: <523369..>525759
location: region:523369-525759:1
so has part: feature:523369-525759:1:exon
subclass of: SO_0000010

856916
type: Gene
SIO_000068: ncbigene

position:523369:1
position: 523369
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:525759:1
position: 525759
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:523369-525759:1:exon

YER169W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: KDM4
gene: RPH1
locus tag: YER169W
gene synonym: KDM4
product: Rph1p
transcript id: NM_001179059.1
SIO_010081: YER169W
subclass of: SO_0000673
so part of: YER169W
location: <523369..>525759
location: region:523369-525759:1
so has part: feature:523369-525759:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:523369-525759:1:exon

YER169W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: KDM4
gene: RPH1
locus tag: YER169W
gene synonym: KDM4
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10523651]
experiment: EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10523651]
experiment: EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10523651]
experiment: EXISTENCE:direct assay:GO:0032454 histone H3K9 demethylase activity [PMID:17371840]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:21296759|PMID:19111667]
experiment: EXISTENCE:direct assay:GO:0051864 histone H3K36 demethylase activity [PMID:17369256|PMID:17371840|PMID:17525156]
experiment: EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:25660547]
experiment: EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:25660547]
experiment: EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:17525156]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:25660547]
experiment: EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10523651]
experiment: EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:25660547]
experiment: EXISTENCE:mutant phenotype:GO:0043565 sequence-specific DNA binding [PMID:21296759]
experiment: EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17369256|PMID:17371840|PMID:17525156]
note: JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
codon start: 1
product: Rph1p
translation: MTKLIAPSEIVGGVPVFKPTYEQFEDFYAYCKAINKYGMKSGVVKVIPPKEWKDKLDLPYSAETLQKIKIKSPIQQHISGNKGLFMVQNVEKNKTYNIIQWKDLSKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSFNIDDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLPNILDHMETKVPGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNCPEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFALEEWLPIGKKAGKCHCISDSVEIDVKKLAKSWRDNNKESKGTPPLNQLPNPAMPLLHRPTLKEMESSSLRSTSPDVGHFSNFKSKSSGVSSPLLSRMKDYSNIVEPTLEDPTLKLKRISSFQEQPLNKLLKRETSQTAMLTDHEDNIVAMSLTSMANSAASSPRLPLSRLNSSNELSNAQPLLDMTNNTLAFPRPNGPSGLNPLLYISNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNISRESSRSPIALNYEARQQHSQQHSFSTPSTVSNLSTSVLGPLSDTNDIKTPHPERPNHKTANRILKKESPVETSKSNLILSKVASTRQEDSFTSRNDDLDKEQGSSPLNSKFAPEEIVLSGKNKIYICKECQRKFSSGHHLTRHKKSVHSGEKPHSCPKCGKRFKRRDHVLQHLNKKIPCISNETTVDAPIMNPTVQPQDGKAAINQQSTPLN
SIO_010081: YER169W
subclass of: SO_0000673
so part of: YER169W
location: 523369..525759
location: region:523369-525759:1
so has part: feature:523369-525759:1:exon

NP_011096.1
type: Protein
SIO_000068: ncbiprotein

S000000971
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:523369-525759:1:exon

YER170W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: AKY3
alternative label: PAK3
gene: ADK2
locus tag: YER170W
gene synonym: AKY3; PAK3
so part of: sequence
location: <525974..>526651
location: region:525974-526651:1
so has part: feature:525974-526651:1:exon
subclass of: SO_0000010

856917
type: Gene
SIO_000068: ncbigene

position:525974:1
position: 525974
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:526651:1
position: 526651
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:525974-526651:1:exon

YER170W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: AKY3
alternative label: PAK3
gene: ADK2
locus tag: YER170W
gene synonym: AKY3; PAK3
product: adenylate kinase ADK2
transcript id: NM_001179060.3
SIO_010081: YER170W
subclass of: SO_0000673
so part of: YER170W
location: <525974..>526651
location: region:525974-526651:1
so has part: feature:525974-526651:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:525974-526651:1:exon

YER170W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: AKY3
alternative label: PAK3
gene: ADK2
locus tag: YER170W
gene synonym: AKY3; PAK3
EC number: 2.7.4.10
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15753074|PMID:8537371]
experiment: EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8537371]
experiment: EXISTENCE:direct assay:GO:0009117 nucleotide metabolic process [PMID:15753074]
experiment: EXISTENCE:direct assay:GO:0046899 nucleoside triphosphate adenylate kinase activity [PMID:15753074|PMID:8537371]
note: Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
codon start: 1
product: adenylate kinase ADK2
translation: MKADAKQITHLLKPLRLLLLGAPGSGKGTQTSRLLKQIPQLSSISSGDILRQEIKSESTLGREATTYIAQGKLLPDDLITRLITFRLSALGWLKPSAMWLLDGFPRTTAQASALDELLKQHDASLNLVVELDVPESTILERIENRYVHVPSGRVYNLQYNPPKVPGLDDITGEPLTKRLDDTAEVFKKRLEEYKKTNEPLKDYYKKSGIFGTVSGETSDIIFRNY
SIO_010081: YER170W
subclass of: SO_0000673
so part of: YER170W
location: 525974..526651
location: region:525974-526651:1
so has part: feature:525974-526651:1:exon

NP_011097.3
type: Protein
SIO_000068: ncbiprotein

S000000972
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:525974-526651:1:exon

YER171W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: REM1
gene: RAD3
locus tag: YER171W
gene synonym: REM1
so part of: sequence
location: <527082..>529418
location: region:527082-529418:1
so has part: feature:527082-529418:1:exon
subclass of: SO_0000010

856918
type: Gene
SIO_000068: ncbigene

position:527082:1
position: 527082
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:529418:1
position: 529418
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:527082-529418:1:exon

YER171W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: REM1
gene: RAD3
locus tag: YER171W
gene synonym: REM1
product: TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
transcript id: NM_001179061.3
SIO_010081: YER171W
subclass of: SO_0000673
so part of: YER171W
location: <527082..>529418
location: region:527082-529418:1
so has part: feature:527082-529418:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:527082-529418:1:exon

YER171W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: REM1
gene: RAD3
locus tag: YER171W
gene synonym: REM1
EC number: 3.6.4.12
experiment: EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]
experiment: EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:8132553]
experiment: EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]
experiment: EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]
experiment: EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:2957691]
experiment: EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:2827162]
experiment: EXISTENCE:direct assay:GO:0070816 phosphorylation of RNA polymerase II C-terminal domain [PMID:19450536|PMID:19679665]
experiment: EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:10713167|PMID:9799251]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7026973]
experiment: EXISTENCE:mutant phenotype:GO:0010525 regulation of transposition, RNA-mediated [PMID:10713167]
experiment: EXISTENCE:mutant phenotype:GO:0045951 positive regulation of mitotic recombination [PMID:24189665]
note: 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
codon start: 1
product: TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3
translation: MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLPKWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKDQGGFIENENKEGEQDEDEDEDIEMQ
SIO_010081: YER171W
subclass of: SO_0000673
so part of: YER171W
location: 527082..529418
location: region:527082-529418:1
so has part: feature:527082-529418:1:exon

NP_011098.3
type: Protein
SIO_000068: ncbiprotein

S000000973
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:527082-529418:1:exon

YER172C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: PRP44
alternative label: RSS1
alternative label: SLT22
alternative label: SNU246
gene: BRR2
locus tag: YER172C
gene synonym: PRP44; RSS1; SLT22; SNU246
so part of: sequence
location: complement(<529530..>536021)
location: region:529530-536021:-1
so has part: feature:529530-536021:-1:exon
subclass of: SO_0000010

856919
type: Gene
SIO_000068: ncbigene

position:529530:-1
position: 529530
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:536021:-1
position: 536021
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:529530-536021:-1:exon

YER172C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: PRP44
alternative label: RSS1
alternative label: SLT22
alternative label: SNU246
gene: BRR2
locus tag: YER172C
gene synonym: PRP44; RSS1; SLT22; SNU246
product: ATP-dependent RNA helicase BRR2
transcript id: NM_001179062.1
SIO_010081: YER172C
subclass of: SO_0000673
so part of: YER172C
location: complement(<529530..>536021)
location: region:529530-536021:-1
so has part: feature:529530-536021:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:529530-536021:-1:exon

YER172C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: PRP44
alternative label: RSS1
alternative label: SLT22
alternative label: SNU246
gene: BRR2
locus tag: YER172C
gene synonym: PRP44; RSS1; SLT22; SNU246
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:8649518]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]
experiment: EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419|PMID:8670905]
experiment: EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:9705931]
experiment: EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:9705931|PMID:8649518]
note: RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
codon start: 1
product: ATP-dependent RNA helicase BRR2
translation: MTEHETKDKAKKIREIYRYDEMSNKVLKVDKRFMNTSQNPQRDAEISQPKSMSGRISAKDMGQGLCNNINKGLKENDVAVEKTGKSASLKKIQQHNTILNSSSDFRLHYYPKDPSNVETYEQILQWVTEVLGNDIPHDLIIGTADIFIRQLKENEENEDGNIEERKEKIQHELGINIDSLKFNELVKLMKNITDYETHPDNSNKQAVAILADDEKSDEEEVTEMSNNANVLGGEINDNEDDDEEYDYNDVEVNSKKKNKRALPNIENDIIKLSDSKTSNIESVPIYSIDEFFLQRKLRSELGYKDTSVIQDLSEKILNDIETLEHNPVALEQKLVDLLKFENISLAEFILKNRSTIFWGIRLAKSTENEIPNLIEKMVAKGLNDLVEQYKFRETTHSKRELDSGDDQPQSSEAKRTKFSNPAIPPVIDLEKIKFDESSKLMTVTKVSLPEGSFKRVKPQYDEIHIPAPSKPVIDYELKEITSLPDWCQEAFPSSETTSLNPIQSKVFHAAFEGDSNMLICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALVQEQVREFQRRLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLIIDEIHLLHDDRGPVLESIVARTFWASKYGQEYPRIIGLSATLPNYEDVGRFLRVPKEGLFYFDSSFRPCPLSQQFCGIKERNSLKKLKAMNDACYEKVLESINEGNQIIVFVHSRKETSRTATWLKNKFAEENITHKLTKNDAGSKQILKTEAANVLDPSLRKLIESGIGTHHAGLTRSDRSLSEDLFADGLLQVLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQMLGRAGRPRYDTFGEGIIITDQSNVQYYLSVLNQQLPIESQFVSKLVDNLNAEVVAGNIKCRNDAVNWLAYTYLYVRMLASPMLYKVPDISSDGQLKKFRESLVHSALCILKEQELVLYDAENDVIEATDLGNIASSFYINHASMDVYNRELDEHTTQIDLFRIFSMSEEFKYVSVRYEEKRELKQLLEKAPIPIREDIDDPLAKVNVLLQSYFSQLKFEGFALNSDIVFIHQNAGRLLRAMFEICLKRGWGHPTRMLLNLCKSATTKMWPTNCPLRQFKTCPVEVIKRLEASTVPWGDYLQLETPAEVGRAIRSEKYGKQVYDLLKRFPKMSVTCNAQPITRSVMRFNIEIIADWIWDMNVHGSLEPFLLMLEDTDGDSILYYDVLFITPDIVGHEFTLSFTYELKQHNQNNLPPNFFLTLISENWWHSEFEIPVSFNGFKLPKKFPPPTPLLENISISTSELGNDDFSEVFEFKTFNKIQSQVFESLYNSNDSVFVGSGKGTGKTAMAELALLNHWRQNKGRAVYINPSGEKIDFLLSDWNKRFSHLAGGKIINKLGNDPSLNLKLLAKSHVLLATPVQFELLSRRWRQRKNIQSLELMIYDDAHEISQGVYGAVYETLISRMIFIATQLEKKIRFVCLSNCLANARDFGEWAGMTKSNIYNFSPSERIEPLEINIQSFKDVEHISFNFSMLQMAFEASAAAAGNRNSSSVFLPSRKDCMEVASAFMKFSKAIEWDMLNVEEEQIVPYIEKLTDGHLRAPLKHGVGILYKGMASNDERIVKRLYEYGAVSVLLISKDCSAFACKTDEVIILGTNLYDGAEHKYMPYTINELLEMVGLASGNDSMAGKVLILTSHNMKAYYKKFLIEPLPTESYLQYIIHDTLNNEIANSIIQSKQDCVDWFTYSYFYRRIHVNPSYYGVRDTSPHGISVFLSNLVETCLNDLVESSFIEIDDTEAEVTAEVNGGDDEATEIISTLSNGLIASHYGVSFFTIQSFVSSLSNTSTLKNMLYVLSTAVEFESVPLRKGDRALLVKLSKRLPLRFPEHTSSGSVSFKVFLLLQAYFSRLELPVDFQNDLKDILEKVVPLINVVVDILSANGYLNATTAMDLAQMLIQGVWDVDNPLRQIPHF…
SIO_010081: YER172C
subclass of: SO_0000673
so part of: YER172C
location: complement(529530..536021)
location: region:529530-536021:-1
so has part: feature:529530-536021:-1:exon

NP_011099.1
type: Protein
SIO_000068: ncbiprotein

S000000974
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:529530-536021:-1:exon

YER173W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: RAD24
locus tag: YER173W
so part of: sequence
location: <536300..>538279
location: region:536300-538279:1
so has part: feature:536300-538279:1:exon
subclass of: SO_0000010

856920
type: Gene
SIO_000068: ncbigene

position:536300:1
position: 536300
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:538279:1
position: 538279
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:536300-538279:1:exon

YER173W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: RAD24
locus tag: YER173W
product: Rad24p
transcript id: NM_001179063.1
SIO_010081: YER173W
subclass of: SO_0000673
so part of: YER173W
location: <536300..>538279
location: region:536300-538279:1
so has part: feature:536300-538279:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:536300-538279:1:exon

YER173W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: RAD24
locus tag: YER173W
experiment: EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:12604797]
experiment: EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:9564050]
experiment: EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:11267834]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511543]
experiment: EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]
note: Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
codon start: 1
product: Rad24p
translation: MDSTNLNKRPLLQYSLSSLGSQITKWSSSRPTSPVRKARSTENDFLSKQDTSSILPSINDDGGEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAMFLPNAKHRILLLSGPSGCSKSTVIKELSKILVPKYRQNSNGTSFRSTPNEHKVTEFRGDCIVNDLPQMESFSEFLKGARYLVMSNLSLILIEDLPNVFHIDTRRRFQQLILQWLYSSEPLLPPLVICITECEIPENDNNYRKFGIDYTFSAETIMNKEILMHPRLKRIKFNPINSTLLKKHLKFICVQNMKMLKEKNKWNKRQEVIDYIAQETGDIRSAITTLQFWATSSGSLPISTRESTISYFHAIGKVIHGSHSTNNDNEMINNLFENSNNLLSKEDFKLGILENYNTFNKGEFSISDASSIVDCLSECDNMNGLPESNEYGLREVRKTFRNISKQGHNHGTVYFPREWKVRKLQNSFKVQAEDWLNVSLYKYNAVHSFRNITLEFGYYAPLIRKCQSYKKKYILYYLKNLPSGSSGPKQTMDKFSDIMKVENGIDVVDRIGGPIEALSVEDGLAPLMDNDSNNCDHLEDQKKERDRRLRMLIDQYERNVMMANDDLEDEETSFNDDPIVDSDSDNSNNIGNETFGRSDEDESLCEILSQRQPRKAPVISESLSDSDLEIL
SIO_010081: YER173W
subclass of: SO_0000673
so part of: YER173W
location: 536300..538279
location: region:536300-538279:1
so has part: feature:536300-538279:1:exon

NP_011100.1
type: Protein
SIO_000068: ncbiprotein

S000000975
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:536300-538279:1:exon

YER174C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: GRX4
locus tag: YER174C
so part of: sequence
location: complement(<538434..>539168)
location: region:538434-539168:-1
so has part: feature:538434-539168:-1:exon
subclass of: SO_0000010

856921
type: Gene
SIO_000068: ncbigene

position:538434:-1
position: 538434
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:539168:-1
position: 539168
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:538434-539168:-1:exon

YER174C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: GRX4
locus tag: YER174C
product: monothiol glutaredoxin GRX4
transcript id: NM_001179064.3
SIO_010081: YER174C
subclass of: SO_0000673
so part of: YER174C
location: complement(<538434..>539168)
location: region:538434-539168:-1
so has part: feature:538434-539168:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:538434-539168:-1:exon

YER174C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: GRX4
locus tag: YER174C
experiment: EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:32098918]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14519092]
experiment: EXISTENCE:genetic interaction:GO:0006879 cellular iron ion homeostasis [PMID:17074835]
experiment: EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543|PMID:27085841]
experiment: EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:20889785]
experiment: EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10567543|PMID:17074835]
experiment: EXISTENCE:mutant phenotype:GO:2000678 negative regulation of transcription regulatory region DNA binding [PMID:23045394]
experiment: EXISTENCE:physical interaction:GO:0006879 cellular iron ion homeostasis [PMID:17074835]
experiment: EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:23045394]
note: Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress
codon start: 1
product: monothiol glutaredoxin GRX4
translation: MTVVEIKSQDQFTQLTTTNAANKLIVLYFKAQWADPCKTMSQVLEAVSEKVRQEDVRFLSIDADEHPEISDLFEIAAVPYFVFIQNGTIVKEISAADPKEFVKSLEILSNASASLANNAKGPKSTSDEESSGSSDDEEDETEEEINARLVKLVQAAPVMLFMKGSPSEPKCGFSRQLVGILREHQIRFGFFDILRDENVRQSLKKFSDWPTFPQLYINGEFQGGLDIIKESIEEDPEYFQHALQ
SIO_010081: YER174C
subclass of: SO_0000673
so part of: YER174C
location: complement(538434..539168)
location: region:538434-539168:-1
so has part: feature:538434-539168:-1:exon

NP_011101.3
type: Protein
SIO_000068: ncbiprotein

S000000976
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:538434-539168:-1:exon

YER175C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: TAM1
gene: TMT1
locus tag: YER175C
gene synonym: TAM1
so part of: sequence
location: complement(<539464..>540363)
location: region:539464-540363:-1
so has part: feature:539464-540363:-1:exon
subclass of: SO_0000010

856922
type: Gene
SIO_000068: ncbigene

position:539464:-1
position: 539464
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540363:-1
position: 540363
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:539464-540363:-1:exon

YER175C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: TAM1
gene: TMT1
locus tag: YER175C
gene synonym: TAM1
product: trans-aconitate 3-methyltransferase
transcript id: NM_001179065.3
SIO_010081: YER175C
subclass of: SO_0000673
so part of: YER175C
location: complement(<539464..>540363)
location: region:539464-540363:-1
so has part: feature:539464-540363:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:539464-540363:-1:exon

YER175C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: TAM1
gene: TMT1
locus tag: YER175C
gene synonym: TAM1
EC number: 2.1.1.145
experiment: EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11695919]
experiment: EXISTENCE:direct assay:GO:0034198 cellular response to amino acid starvation [PMID:18092814]
experiment: EXISTENCE:direct assay:GO:0046547 trans-aconitate 3-methyltransferase activity [PMID:11695919]
note: Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
codon start: 1
product: trans-aconitate 3-methyltransferase
translation: MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV
SIO_010081: YER175C
subclass of: SO_0000673
so part of: YER175C
location: complement(539464..540363)
location: region:539464-540363:-1
so has part: feature:539464-540363:-1:exon

NP_011102.3
type: Protein
SIO_000068: ncbiprotein

S000000977
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:539464-540363:-1:exon

YER175W-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER175W-A
so part of: sequence
location: <540650..>540814
location: region:540650-540814:1
so has part: feature:540650-540814:1:exon
subclass of: SO_0000010

1466537
type: Gene
SIO_000068: ncbigene

position:540650:1
position: 540650
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:540814:1
position: 540814
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:540650-540814:1:exon

YER175W-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER175W-A
product: uncharacterized protein
transcript id: NM_001184589.1
SIO_010081: YER175W-A
subclass of: SO_0000673
so part of: YER175W-A
location: <540650..>540814
location: region:540650-540814:1
so has part: feature:540650-540814:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:540650-540814:1:exon

YER175W-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER175W-A
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MRLHKTFICFSQNKRGCRNILQENSRMIFENKILIMILRQGIFFNISVSTKISF
SIO_010081: YER175W-A
subclass of: SO_0000673
so part of: YER175W-A
location: 540650..540814
location: region:540650-540814:1
so has part: feature:540650-540814:1:exon

NP_878069.1
type: Protein
SIO_000068: ncbiprotein

S000028625
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:540650-540814:1:exon

YER176W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: HEL1
alternative label: MTT1
gene: ECM32
locus tag: YER176W
gene synonym: HEL1; MTT1
so part of: sequence
location: <541690..>545055
location: region:541690-545055:1
so has part: feature:541690-545055:1:exon
subclass of: SO_0000010

856923
type: Gene
SIO_000068: ncbigene

position:541690:1
position: 541690
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:545055:1
position: 545055
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:541690-545055:1:exon

YER176W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: HEL1
alternative label: MTT1
gene: ECM32
locus tag: YER176W
gene synonym: HEL1; MTT1
product: RNA helicase
transcript id: NM_001179066.1
SIO_010081: YER176W
subclass of: SO_0000673
so part of: YER176W
location: <541690..>545055
location: region:541690-545055:1
so has part: feature:541690-545055:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:541690-545055:1:exon

YER176W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: HEL1
alternative label: MTT1
gene: ECM32
locus tag: YER176W
gene synonym: HEL1; MTT1
EC number: 3.6.4.13
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9434351]
experiment: EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]
experiment: EXISTENCE:direct assay:GO:0005844 polysome [PMID:10836794]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]
experiment: EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:10836794]
note: DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
codon start: 1
product: RNA helicase
translation: MDFQCRTCSQAYDAEQMMKHLSSTRHKTVFDTSNDEDICCEECQDKNIHQLQIIRFGGEDMVLLCNSCFRKEYSETERPSTSYSLQNGSILKFWEKYVKVRECCCDECGEESNLNANRNGEVLCDKCLPKSNRAKDFVSEKSGRFLYIYLGLNETQNSTRKPRKKGGRRVGRGKKGRKGAKIKKEKKETFEAKISRIAYEVKKENSTIQSSSSSNLRNFKGFKAVESDPVVAAKVSKSETSRSNPGPSNRNKGKGNKANHKKNSGNGIGKEKERKTNIRNNVRNSQPIPEDRKNTNSHVTTNSGGKGKNESVDKHQLPQPKALNGNGSGSTNTTGLKKGKKDHAGQKTKGNDKTGNKNPREAKLNSAGRKNALGKKSNNQPNKGTSRWTIGSDTESSREPSISPNENTTSITKSRNRNKKASKPTLNEKSKTTTMPKKLETKNQEKNNGKTKDGKLIYEEGEPLTRYNTFKSTLSYPDLNTYLNDYSFALFLEQKLENEFVQNFNILWPRNEKDTAFIINVEKNNNSELEKLLPANLLALGRPAFNERQPFFFCTQDEQKVWYIFIKELSIQRGKYVLLVELFSWNNLSLPTKNGSSQFKLLPTSAQTSRILFAMTRITNPKFIDLLLGQKPIKEIYFDNRLKFSSDKLNRSQKTAVEHVLNNSITILQGPPGTGKTSTIEEIIIQVIERFHAFPILCVAASNIAIDNIAEKIMENRPQIKILRILSKKKEQQYSDDHPLGEICLHNIVYKNLSPDMQVVANKTRRGEMISKSEDTKFYKEKNRVTNKVVSQSQIIFTTNIAAGGRELKVIKECPVVIMDEATQSSEASTLVPLSLPGIRNFVFVGDEKQLSSFSNIPQLETSLFERVLSNGTYKNPLMLDTQYRMHPKISEFPIKKIYNGELKDGVTDEQKAWPGVQHPLFFYQCDLGPESRVRSTQRDIVGFTYENKHECVEIVKIIQILMLDKKVPLEEIGVITPYSAQRDLLSDILTKNVVINPKQISMQQEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVATVDSFQGHEKSFIIFSCVRNNTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYITYLEEQEVIFTDLTAY
SIO_010081: YER176W
subclass of: SO_0000673
so part of: YER176W
location: 541690..545055
location: region:541690-545055:1
so has part: feature:541690-545055:1:exon

NP_011103.1
type: Protein
SIO_000068: ncbiprotein

S000000978
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:541690-545055:1:exon

YER177W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: APR6
gene: BMH1
locus tag: YER177W
gene synonym: APR6
so part of: sequence
location: <545611..>546414
location: region:545611-546414:1
so has part: feature:545611-546414:1:exon
subclass of: SO_0000010

856924
type: Gene
SIO_000068: ncbigene

position:545611:1
position: 545611
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:546414:1
position: 546414
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:545611-546414:1:exon

YER177W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: APR6
gene: BMH1
locus tag: YER177W
gene synonym: APR6
product: 14-3-3 family protein BMH1
transcript id: NM_001179067.3
SIO_010081: YER177W
subclass of: SO_0000673
so part of: YER177W
location: <545611..>546414
location: region:545611-546414:1
so has part: feature:545611-546414:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:545611-546414:1:exon

YER177W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: APR6
gene: BMH1
locus tag: YER177W
gene synonym: APR6
experiment: EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12167636]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12167636|PMID:25409301|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25409301|PMID:22842922]
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]
experiment: EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]
experiment: EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:24142105]
experiment: EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9215628]
experiment: EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:24850890]
experiment: EXISTENCE:genetic interaction:GO:0034221 fungal-type cell wall chitin biosynthetic process [PMID:17559233]
experiment: EXISTENCE:genetic interaction:GO:0070873 regulation of glycogen metabolic process [PMID:9215628]
experiment: EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:14704161]
experiment: EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:24142105]
experiment: EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:22785534]
experiment: EXISTENCE:mutant phenotype:GO:0050815 phosphoserine residue binding [PMID:9822578]
experiment: EXISTENCE:mutant phenotype:GO:0070842 aggresome assembly [PMID:23843611]
experiment: EXISTENCE:physical interaction:GO:1904667 negative regulation of ubiquitin protein ligase activity [PMID:17030612]
note: 14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins
codon start: 1
product: 14-3-3 family protein BMH1
translation: MSTSREDSVYLAKLAEQAERYEEMVENMKTVASSGQELSVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKEKSEHQVELICSYRSKIETELTKISDDILSVLDSHLIPSATTGESKVFYYKMKGDYHRYLAEFSSGDAREKATNASLEAYKTASEIATTELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMSESGQAEDQQQQQQHQQQQPPAAAEGEAPK
SIO_010081: YER177W
subclass of: SO_0000673
so part of: YER177W
location: 545611..546414
location: region:545611-546414:1
so has part: feature:545611-546414:1:exon

NP_011104.3
type: Protein
SIO_000068: ncbiprotein

S000000979
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:545611-546414:1:exon

YER178W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PDA1
locus tag: YER178W
so part of: sequence
location: <546817..>548079
location: region:546817-548079:1
so has part: feature:546817-548079:1:exon
subclass of: SO_0000010

856925
type: Gene
SIO_000068: ncbigene

position:546817:1
position: 546817
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:548079:1
position: 548079
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:546817-548079:1:exon

YER178W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PDA1
locus tag: YER178W
product: pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha
transcript id: NM_001179068.3
SIO_010081: YER178W
subclass of: SO_0000673
so part of: YER178W
location: <546817..>548079
location: region:546817-548079:1
so has part: feature:546817-548079:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:546817-548079:1:exon

YER178W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PDA1
locus tag: YER178W
EC number: 1.2.4.1
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7589446|PMID:14576278|PMID:16823961|PMID:24769239]
experiment: EXISTENCE:direct assay:GO:0005967 mitochondrial pyruvate dehydrogenase complex [PMID:2007123]
experiment: EXISTENCE:direct assay:GO:0006086 acetyl-CoA biosynthetic process from pyruvate [PMID:7947791]
experiment: EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]
experiment: EXISTENCE:mutant phenotype:GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity [PMID:11589696]
experiment: EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]
note: E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes
codon start: 1
product: pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha
translation: MLAASFKRQPSQLVRGLGAVLRTPTRIGHVRTMATLKTTDKKAPEDIEGSDTVQIELPESSFESYMLEPPDLSYETSKATLLQMYKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKLDSIITSYRCHGFTFMRGASVKAVLAELMGRRAGVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKLWNLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFAKDWCLSGKGPLVLEYETYRYGGHSMSDPGTTYRTRDEIQHMRSKNDPIAGLKMHLIDLGIATEAEVKAYDKSARKYVDEQVELADAAPPPEAKLSILFEDVYVKGTETPTLRGRIPEDTWDFKKQGFASRD
SIO_010081: YER178W
subclass of: SO_0000673
so part of: YER178W
location: 546817..548079
location: region:546817-548079:1
so has part: feature:546817-548079:1:exon

NP_011105.4
type: Protein
SIO_000068: ncbiprotein

S000000980
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:546817-548079:1:exon

YER179W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: ISC2
gene: DMC1
locus tag: YER179W
gene synonym: ISC2
so part of: sequence
location: <548421..>549517
location: region:548421-549517:1
so has part: feature:548421-549517:1:exon
subclass of: SO_0000010

856926
type: Gene
SIO_000068: ncbigene

position:548421:1
position: 548421
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:549517:1
position: 549517
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:548421-549517:1:exon

YER179W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: ISC2
gene: DMC1
locus tag: YER179W
gene synonym: ISC2
product: recombinase DMC1
transcript id: NM_001179069.1
SIO_010081: YER179W
subclass of: SO_0000673
so part of: YER179W
location: join(<548421..548552,548645..>549517)
location: region:548421-549517:1
so has part: feature:548421-548552:1:exon
so has part: feature:548645-549517:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:548421-548552:1:exon

position:548552:1
position: 548552
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 2
SIO_000628: feature:548645-549517:1:exon

position:548645:1
position: 548645
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

YER179W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: ISC2
gene: DMC1
locus tag: YER179W
gene synonym: ISC2
experiment: EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:23769192]
experiment: EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:1581960]
experiment: EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:11551925]
experiment: EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11551925]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141|PMID:7528104]
experiment: EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:30301803]
experiment: EXISTENCE:genetic interaction:GO:0007130 synaptonemal complex assembly [PMID:24367271]
experiment: EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:22955832|PMID:9323140]
experiment: EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:1581960|PMID:16581767]
experiment: EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:1581960]
note: Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes and for the normal morphogenesis of synaptonemal complex; binds ssDNA and dsDNA, forms helical filaments; potent inhibitor of the ATPase activity of Srs2p helicase, blocking its ssDNA translocating motor activity and inhibiting its antirecombinase activity; stimulated by Rdh54p; homolog of Rad51p and the bacterial RecA protein
codon start: 1
product: recombinase DMC1
translation: MSVTGTEIDSDTAKNILSVDELQNYGINASDLQKLKSGGIYTVNTVLSTTRRHLCKIKGLSEVKVEKIKEAAGKIIQVGFIPATVQLDIRQRVYSLSTGSKQLDSILGGGIMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPERIKQIAEGYELDPESCLANVSYARALNSEHQMELVEQLGEELSSGDYRLIVVDSIMANFRVDYCGRGELSERQQKLNQHLFKLNRLAEEFNVAVFLTNQVQSDPGASALFASADGRKPIGGHVLAHASATRILLRKGRGDERVAKLQDSPDMPEKECVYVIGEKGITDSSD
SIO_010081: YER179W
subclass of: SO_0000673
so part of: YER179W
location: join(548421..548552,548645..549517)
location: region:548421-549517:1
so has part: feature:548421-548552:1:exon
so has part: feature:548645-549517:1:exon

NP_011106.1
type: Protein
SIO_000068: ncbiprotein

S000000981
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:548421-548552:1:exon

urn:…
SIO_000300: 2
SIO_000628: feature:548645-549517:1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS522; Autonomously Replicating Sequence; active origin of replication near the right end of Chromosome V that is activated late in S phase, late activation appears to result from telomeric proximity
so part of: sequence
location: 549566..549814
location: region:549566-549814:1
so has part: feature:549566-549814:1:region

S000077394
type: SGD
SIO_000068: sgd

position:549566:1
position: 549566
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:549814:1
position: 549814
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549566-549814:1:region

YER180C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: ISC10
locus tag: YER180C
so part of: sequence
location: complement(<549724..>550527)
location: region:549724-550527:-1
so has part: feature:549724-550527:-1:exon
subclass of: SO_0000010

856927
type: Gene
SIO_000068: ncbigene

position:549724:-1
position: 549724
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:550527:-1
position: 550527
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:549724-550527:-1:exon

YER180C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: ISC10
locus tag: YER180C
product: Isc10p
transcript id: NM_001179070.1
SIO_010081: YER180C
subclass of: SO_0000673
so part of: YER180C
location: complement(<549724..>550527)
location: region:549724-550527:-1
so has part: feature:549724-550527:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:549724-550527:-1:exon

YER180C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: ISC10
locus tag: YER180C
experiment: EXISTENCE:direct assay:GO:0004860 protein kinase inhibitor activity [PMID:32423992]
experiment: EXISTENCE:direct assay:GO:0051019 mitogen-activated protein kinase binding [PMID:32423992]
experiment: EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8455558]
note: Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II
codon start: 1
product: Isc10p
translation: MDVDERLHQDENQTHPFSQKKSSSFLIKEKAATKSKDLEHIRLRDLNFNHRKKLDDKKLAKQIPVKANFKKPNEIEARANLNSNELTDINLDYIPDSPSIEKISGPEDSIVVTPRNIIHLQSDSDIILEECEHNYDCSPFYRLFNYENRIEPDDYEAIINAIITDEIAGTYPVFERELEYQELKSLVRKRDYIMYYFLSRDYRGFFQLKEERTLFYRYPSIAYTSPLRYLDNGSETEQFTGDDDEELQSFDFENTSSVRTLDSNIWR
SIO_010081: YER180C
subclass of: SO_0000673
so part of: YER180C
location: complement(549724..550527)
location: region:549724-550527:-1
so has part: feature:549724-550527:-1:exon

NP_011107.1
type: Protein
SIO_000068: ncbiprotein

S000000982
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:549724-550527:-1:exon

YER180C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: SLO1
locus tag: YER180C-A
so part of: sequence
location: complement(<550865..>551122)
location: region:550865-551122:-1
so has part: feature:550865-551122:-1:exon
subclass of: SO_0000010

856928
type: Gene
SIO_000068: ncbigene

position:550865:-1
position: 550865
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551122:-1
position: 551122
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:550865-551122:-1:exon

YER180C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: SLO1
locus tag: YER180C-A
product: Slo1p
transcript id: NM_001184517.3
SIO_010081: YER180C-A
subclass of: SO_0000673
so part of: YER180C-A
location: complement(<550865..>551122)
location: region:550865-551122:-1
so has part: feature:550865-551122:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:550865-551122:-1:exon

YER180C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: SLO1
locus tag: YER180C-A
experiment: EXISTENCE:physical interaction:GO:0006886 intracellular protein transport [PMID:12620189]
note: Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
codon start: 1
product: Slo1p
translation: MSAENISTGSPTGKQPSSEVNLGEREAGTKNERMMRQTKLLKDTLDLLWNKTLEQQEVCEQLKQENDYLEDYIGNLMRSSNVLEK
SIO_010081: YER180C-A
subclass of: SO_0000673
so part of: YER180C-A
location: complement(550865..551122)
location: region:550865-551122:-1
so has part: feature:550865-551122:-1:exon

NP_796378.3
type: Protein
SIO_000068: ncbiprotein

S000028437
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:550865-551122:-1:exon

YNCE0029C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YNCE0029C
so part of: sequence
location: complement(551285..551358)
location: region:551285-551358:-1
so has part: feature:551285-551358:-1:exon
subclass of: SO_0000663

856929
type: Gene
SIO_000068: ncbigene

position:551285:-1
position: 551285
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:551358:-1
position: 551358
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551285-551358:-1:exon

YNCE0029C
type: Transfer RNA
subclass of: SO_0000253
RO_0002162: 559292
locus tag: YNCE0029C
product: tRNA-Ile
experiment: EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9023104]
experiment: EXISTENCE:curator inference:GO:0006414 translational elongation [PMID:9023104]
note: Isoleucine tRNA (tRNA-Ile), predicted by tRNAscan-SE analysis
SIO_010081: YNCE0029C
subclass of: SO_0000673
so part of: YNCE0029C
location: complement(551285..551358)
location: region:551285-551358:-1
so has part: feature:551285-551358:-1:exon

S000006603
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551285-551358:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 551442..551773
location: region:551442-551773:1
so has part: feature:551442-551773:1:region

S000006921
type: SGD
SIO_000068: sgd

position:551442:1
position: 551442
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:551773:1
position: 551773
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551442-551773:1:region

YER181C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER181C
so part of: sequence
location: complement(<551473..>551796)
location: region:551473-551796:-1
so has part: feature:551473-551796:-1:exon
subclass of: SO_0000010

856930
type: Gene
SIO_000068: ncbigene

position:551473:-1
position: 551473
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:551796:-1
position: 551796
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:551473-551796:-1:exon

YER181C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER181C
product: uncharacterized protein
transcript id: NM_001348828.1
SIO_010081: YER181C
subclass of: SO_0000673
so part of: YER181C
location: complement(<551473..>551796)
location: region:551473-551796:-1
so has part: feature:551473-551796:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:551473-551796:-1:exon

YER181C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER181C
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
note: Mitochondrial hypothetical protein; conserved among S. cerevisiae strains; extensively overlaps a Ty1 LTR; YER181C is not an essential gene
codon start: 1
product: uncharacterized protein
translation: MLILLRLSEVCVNFVIIIGIPLLIEASILCIQNILELLLKGIGILKFNRYLHTIILRLFFLSFYMLHFPITLSILAFQLPLNLLTLSQASFHLPRSHMILYQQQECY
SIO_010081: YER181C
subclass of: SO_0000673
so part of: YER181C
location: complement(551473..551796)
location: region:551473-551796:-1
so has part: feature:551473-551796:-1:exon

NP_001335770.1
type: Protein
SIO_000068: ncbiprotein

S000000983
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:551473-551796:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty1 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(552040..552267)
location: region:552040-552267:-1
so has part: feature:552040-552267:-1:region

S000006902
type: SGD
SIO_000068: sgd

position:552040:-1
position: 552040
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:552267:-1
position: 552267
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552040-552267:-1:region

YER182W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FMP10
locus tag: YER182W
so part of: sequence
location: <552525..>553259
location: region:552525-553259:1
so has part: feature:552525-553259:1:exon
subclass of: SO_0000010

856931
type: Gene
SIO_000068: ncbigene

position:552525:1
position: 552525
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:553259:1
position: 553259
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:552525-553259:1:exon

YER182W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FMP10
locus tag: YER182W
product: Fmp10p
transcript id: NM_001179072.3
SIO_010081: YER182W
subclass of: SO_0000673
so part of: YER182W
location: <552525..>553259
location: region:552525-553259:1
so has part: feature:552525-553259:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:552525-553259:1:exon

YER182W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FMP10
locus tag: YER182W
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24390141|P MID:24769239]
note: hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
codon start: 1
product: Fmp10p
translation: MFKRIAIAQIRTYTNGVVFKTASKPKRRWIPWTIFGGSFLGGWYLTQHMTFTDLLAYWRYDALPKNADEVVKYHADLNRRLNGLPIVKQLENAGFVQVIANEEENLLVSRALNTPGGVAIPPRVYYNPSRRETVGLYHLGMKLTGYPFLIHGGILATVIEDLMKEAIRLEKGTKNINQETKNLSISYKFPTLANQFVVVRTTDLQQYGNKTKLKAELMDQSGNRTLVKANATFSSEQGNPKEEK
SIO_010081: YER182W
subclass of: SO_0000673
so part of: YER182W
location: 552525..553259
location: region:552525-553259:1
so has part: feature:552525-553259:1:exon

NP_011109.3
type: Protein
SIO_000068: ncbiprotein

S000000984
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:552525-553259:1:exon

YER183C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: FAU1
locus tag: YER183C
so part of: sequence
location: complement(<553334..>553969)
location: region:553334-553969:-1
so has part: feature:553334-553969:-1:exon
subclass of: SO_0000010

856932
type: Gene
SIO_000068: ncbigene

position:553334:-1
position: 553334
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:553969:-1
position: 553969
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:553334-553969:-1:exon

YER183C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: FAU1
locus tag: YER183C
product: 5-formyltetrahydrofolate cyclo-ligase
transcript id: NM_001179073.1
SIO_010081: YER183C
subclass of: SO_0000673
so part of: YER183C
location: complement(<553334..>553969)
location: region:553334-553969:-1
so has part: feature:553334-553969:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:553334-553969:-1:exon

YER183C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: FAU1
locus tag: YER183C
EC number: 6.3.3.2
experiment: EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]
experiment: EXISTENCE:direct assay:GO:0009396 folic acid-containing compound biosynthetic process [PMID:11923304]
experiment: EXISTENCE:direct assay:GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity [PMID:11923304]
note: 5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis
codon start: 1
product: 5-formyltetrahydrofolate cyclo-ligase
translation: MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ
SIO_010081: YER183C
subclass of: SO_0000673
so part of: YER183C
location: complement(553334..553969)
location: region:553334-553969:-1
so has part: feature:553334-553969:-1:exon

NP_011110.1
type: Protein
SIO_000068: ncbiprotein

S000000985
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:553334-553969:-1:exon

YER184C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: TOG1
locus tag: YER184C
so part of: sequence
location: complement(<556296..>558680)
location: region:556296-558680:-1
so has part: feature:556296-558680:-1:exon
subclass of: SO_0000010

856933
type: Gene
SIO_000068: ncbigene

position:556296:-1
position: 556296
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:558680:-1
position: 558680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:556296-558680:-1:exon

YER184C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: TOG1
locus tag: YER184C
product: Tog1p
transcript id: NM_001179074.1
SIO_010081: YER184C
subclass of: SO_0000673
so part of: YER184C
location: complement(<556296..>558680)
location: region:556296-558680:-1
so has part: feature:556296-558680:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:556296-558680:-1:exon

YER184C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: TOG1
locus tag: YER184C
experiment: EXISTENCE:curator inference:GO:0003700 DNA-binding transcription factor activity [PMID:24998441]
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:24998441]
experiment: EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]
experiment: EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:24998441|PMID:19111667]
experiment: EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24998441]
note: Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
codon start: 1
product: Tog1p
translation: MAAKRGLAKQKSRVTKACDRCHRKKIKCNSKKPCFGCIGSQSKCTYRNQFREPIEAFFNYTGSLSNDLDNAKCSIAKLKAQLPPSAPASLQKGLANICTELEKIQPQLYLNLDSKEISSYGGLKSIETEIIGKQSKSLNRFSNAFESNTAQNVSMYFGVYSPLLYFASTGISWITKKLISCSNDRETRETIYLFLKFLDASSASHAGPKVTSISPLEYYSKLNGLSCGNDVLIQHIMSNISNEIKGNTNINQTIKFNKPTDWFMYGVQLMEQHHKALDRKSSKKLLPLKYFLEQDELIFCLCLEYFERSLFSTMYDLTILKGLVSLMKHRYWIDDPFVLGRIISTMSRRSLDAGLNRWEYYIGQDEDTAEEYRKLWWDCYWWDRWYSLVTGKQPLIPHEMTSCLFPKDVVGLGVDDSMDCFTLINLVELDPSKFDICISFGYILLTKIITAVFSGLLYNRHFTDYRLFATPNAKDLNGTARQLMVEFSKICKIFQCIQDKLIPFLKQYSENSNVFELYTHFGFAKVCCFQGMESLILRIQNLLQERERIELDSCVKDIRLQTFEASVDILTDVLKHEDTFYIFRCSWFIYAILMNITLNFIETPRRNSICYLSLMCRMIASYNDLFVSSGNVNFKGNNAFSKKLENGTAVSFILTRICCQMYTRSQKMAKESLFCELKKYGQACSDAGQAALDIECIWYRNIIGEHKESSFRKEILSILDREMGDLVNNRVIGVQGKNQEGACYEKLSPSSTSVSVGMDFCSLENFVTAESLPDLLNLFWEDTEFGITKENLGE
SIO_010081: YER184C
subclass of: SO_0000673
so part of: YER184C
location: complement(556296..558680)
location: region:556296-558680:-1
so has part: feature:556296-558680:-1:exon

NP_011111.1
type: Protein
SIO_000068: ncbiprotein

S000000986
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:556296-558680:-1:exon

YER185W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
gene: PUG1
locus tag: YER185W
so part of: sequence
location: <559454..>560365
location: region:559454-560365:1
so has part: feature:559454-560365:1:exon
subclass of: SO_0000010

856934
type: Gene
SIO_000068: ncbigene

position:559454:1
position: 559454
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:560365:1
position: 560365
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:559454-560365:1:exon

YER185W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
gene: PUG1
locus tag: YER185W
product: Pug1p
transcript id: NM_001179075.3
SIO_010081: YER185W
subclass of: SO_0000673
so part of: YER185W
location: <559454..>560365
location: region:559454-560365:1
so has part: feature:559454-560365:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:559454-560365:1:exon

YER185W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
gene: PUG1
locus tag: YER185W
experiment: EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18326586]
experiment: EXISTENCE:mutant phenotype:GO:0035351 heme transmembrane transport [PMID:18326586]
note: Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins
codon start: 1
product: Pug1p
translation: MSTTDSGFVLYHYTPSKAAAIVFVVLFIIMTVIFAVQTLYAARKSSKALKNNPFESSDDKVDSLEDAEYKQLKITPTVFAFIPFFTGCIMEAVGYIGRALSSSNPERTTPYIIQSVLLLVAPALIAATIYMIFGRLLHVMRCQSLILISARFGTTFFVVGDVFSFFLQAAGGGLMSKAGSTKTGSGLITAGLFVQVIFFGFFIINEIRFTVNVKRRCLFYEDISRKWIFVNATLLLSSMLILLRSIVRIVEFIQGFNGYIISHEYFIYVFDAVPMLLVIIAFSVGSFFGNVFDVIKECQTLSN
SIO_010081: YER185W
subclass of: SO_0000673
so part of: YER185W
location: 559454..560365
location: region:559454-560365:1
so has part: feature:559454-560365:1:exon

NP_011112.3
type: Protein
SIO_000068: ncbiprotein

S000000987
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:559454-560365:1:exon

YER186C
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER186C
so part of: sequence
location: complement(<561705..>562625)
location: region:561705-562625:-1
so has part: feature:561705-562625:-1:exon
subclass of: SO_0000010

856935
type: Gene
SIO_000068: ncbigene

position:561705:-1
position: 561705
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:562625:-1
position: 562625
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:561705-562625:-1:exon

YER186C
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER186C
product: uncharacterized protein
transcript id: NM_001179076.3
SIO_010081: YER186C
subclass of: SO_0000673
so part of: YER186C
location: complement(<561705..>562625)
location: region:561705-562625:-1
so has part: feature:561705-562625:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:561705-562625:-1:exon

YER186C
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER186C
codon start: 1
product: uncharacterized protein
translation: MLWHPDGYEPRVKAIEEEIYANEDRKDVPDKFKFDTVTKTGMVKLRVFKDDLIFKSQRSINLFASRKHPFKSFTADGEGLPLFAFRTKKPFFVRRDYVGFLFYQYEILKNGDFPEESDYEVKGECDGFTLFKVLFCTVKVKKTSYYRNKERISHILELNFGKKEDFRILTLVRCSEIRSVYVVEDKKVIMKWVFTSESKFNLNSSLFIIKAAIGCLPEVGDSIEDIPKFDWDSCPTIGCMCRTKEALFQPESRKDMHICPQLFLGETGPPHYNESSVPWLTKMNICISVLINFLEYTDFMSWMQDN
SIO_010081: YER186C
subclass of: SO_0000673
so part of: YER186C
location: complement(561705..562625)
location: region:561705-562625:-1
so has part: feature:561705-562625:-1:exon

NP_011113.3
type: Protein
SIO_000068: ncbiprotein

S000000988
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:561705-562625:-1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty5 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: complement(563928..564024)
location: region:563928-564024:-1
so has part: feature:563928-564024:-1:region

S000006903
type: SGD
SIO_000068: sgd

position:563928:-1
position: 563928
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

position:564024:-1
position: 564024
reference: sequence
type: ReverseStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:563928-564024:-1:region

YER187W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER187W
so part of: sequence
location: <566230..>566655
location: region:566230-566655:1
so has part: feature:566230-566655:1:exon
subclass of: SO_0000010

856937
type: Gene
SIO_000068: ncbigene

position:566230:1
position: 566230
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:566655:1
position: 566655
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:566230-566655:1:exon

YER187W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER187W
product: uncharacterized protein
transcript id: NM_001179077.1
SIO_010081: YER187W
subclass of: SO_0000673
so part of: YER187W
location: <566230..>566655
location: region:566230-566655:1
so has part: feature:566230-566655:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:566230-566655:1:exon

YER187W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER187W
note: hypothetical protein; induced in respiratory-deficient cells
codon start: 1
product: uncharacterized protein
translation: MLIDQIVAAVPGVPDISGNASALSLQRRSQEFATSWISMTYSQSYGDLAQNWQNDEGGAGNFDSYAEEKLQNFFSGNRDWKYCFAAEDTKNGEPLDYDDIPGDGAGTGSAFKSEIYFNTYGGIDNYCNDEHIGAQNTGDGR
SIO_010081: YER187W
subclass of: SO_0000673
so part of: YER187W
location: 566230..566655
location: region:566230-566655:1
so has part: feature:566230-566655:1:exon

NP_011114.1
type: Protein
SIO_000068: ncbiprotein

S000000989
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:566230-566655:1:exon

YER188W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER188W
so part of: sequence
location: <568040..>568759
location: region:568040-568759:1
so has part: feature:568040-568759:1:exon
subclass of: SO_0000010

856938
type: Gene
SIO_000068: ncbigene

position:568040:1
position: 568040
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:568759:1
position: 568759
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568040-568759:1:exon

YER188W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER188W
product: uncharacterized protein
transcript id: NM_001348829.1
SIO_010081: YER188W
subclass of: SO_0000673
so part of: YER188W
location: <568040..>568759
location: region:568040-568759:1
so has part: feature:568040-568759:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:568040-568759:1:exon

YER188W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER188W
note: hypothetical protein; conserved across S. cerevisiae strains; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
codon start: 1
product: uncharacterized protein
translation: MMPTYLGKLTWSYFFTTLGLACAYNVTEQMEFDQFKSDYLACLAPEHRNIVVDLASNGFITISPMANATIDFEDVTSDYFNCTDVNTNVQVTIASFYNEYGFGPDDNGYYHAMEEPSEFERHDMDVRLYRPYYPGEFVMGRRSDALGVTGFDQKDCAGEGFYDEQTAATSCQNIGSTQYAKSVRSYNYGCCGGAVWIRIWPHHNCSKGHDHHFKIRPGQMLCWNVNPYSWMQPESGWNP
SIO_010081: YER188W
subclass of: SO_0000673
so part of: YER188W
location: 568040..568759
location: region:568040-568759:1
so has part: feature:568040-568759:1:exon

NP_001335771.1
type: Protein
SIO_000068: ncbiprotein

S000000990
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:568040-568759:1:exon

repeat_region
type: Repeat Region
subclass of: SO_0000657
RO_0002162: 559292
note: Ty5 LTR
rpt type: long_terminal_repeat
so part of: sequence
location: 568791..569024
location: region:568791-569024:1
so has part: feature:568791-569024:1:region

S000006922
type: SGD
SIO_000068: sgd

position:568791:1
position: 568791
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:569024:1
position: 569024
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:568791-569024:1:region

telomere
type: Telomere
subclass of: SO_0000624
RO_0002162: 559292
note: TEL05R; Telomeric region on the right arm of Chromosome V; annotated components include an X element core sequence, X element combinatorial repeats, and a long Y' element; TEL05R does have telomeric repeats (TEL05R-TR), but they are missing from the genome annotation due to difficulties encountered during sequencing and/or assembly
so part of: sequence
location: 569599..576874
location: region:569599-576874:1
so has part: feature:569599-576874:1:region

S000028953
type: SGD
SIO_000068: sgd

position:569599:1
position: 569599
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569599-576874:1:region

YER188C-A
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER188C-A
so part of: sequence
location: complement(<569608..>569907)
location: region:569608-569907:-1
so has part: feature:569608-569907:-1:exon
subclass of: SO_0000010

1466538
type: Gene
SIO_000068: ncbigene

position:569608:-1
position: 569608
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:569907:-1
position: 569907
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569608-569907:-1:exon

YER188C-A
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER188C-A
product: uncharacterized protein
transcript id: NM_001184633.1
SIO_010081: YER188C-A
subclass of: SO_0000673
so part of: YER188C-A
location: complement(<569608..>569907)
location: region:569608-569907:-1
so has part: feature:569608-569907:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:569608-569907:-1:exon

YER188C-A
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER188C-A
codon start: 1
product: uncharacterized protein
translation: MAHLSLNQYKCTHIIMHGTCLSGLYPVPFTHKAHDYPHFNIYISFGGPKYCITALNTYVIPLFHHLLSTQFIYTYVNITKKSPLKSPKHKNILSFNDNT
SIO_010081: YER188C-A
subclass of: SO_0000673
so part of: YER188C-A
location: complement(569608..569907)
location: region:569608-569907:-1
so has part: feature:569608-569907:-1:exon

NP_878070.1
type: Protein
SIO_000068: ncbiprotein

S000028764
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:569608-569907:-1:exon

rep_origin
type: Replication Origin
subclass of: SO_0000296
RO_0002162: 559292
note: ARS523; Autonomously Replicating Sequence
so part of: sequence
location: 569618..569695
location: region:569618-569695:1
so has part: feature:569618-569695:1:region

S000077395
type: SGD
SIO_000068: sgd

position:569618:1
position: 569618
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

position:569695:1
position: 569695
reference: sequence
type: ForwardStrandPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:569618-569695:1:region

YER189W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER189W
so part of: sequence
location: <571155..>571523
location: region:571155-571523:1
so has part: feature:571155-571523:1:exon
subclass of: SO_0000010

856939
type: Gene
SIO_000068: ncbigene

position:571155:1
position: 571155
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:571523:1
position: 571523
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:571155-571523:1:exon

YER189W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER189W
product: uncharacterized protein
transcript id: NM_001179079.3
SIO_010081: YER189W
subclass of: SO_0000673
so part of: YER189W
location: <571155..>571523
location: region:571155-571523:1
so has part: feature:571155-571523:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:571155-571523:1:exon

YER189W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER189W
codon start: 1
product: uncharacterized protein
translation: MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRSFYEDEKSGLIKVVKFRTGAMDRKRSFEKIVISVMVGKNVQKFLTFVEDEPDFQGGPIPSNKPRDGLHVVSSAYFEIQ
SIO_010081: YER189W
subclass of: SO_0000673
so part of: YER189W
location: 571155..571523
location: region:571155-571523:1
so has part: feature:571155-571523:1:exon

NP_011116.3
type: Protein
SIO_000068: ncbiprotein

S000000991
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:571155-571523:1:exon

YER190W
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-2
locus tag: YER190W
gene synonym: YRF1
so part of: sequence
location: <571480..>576525
location: region:571480-576525:1
so has part: feature:571480-576525:1:exon
subclass of: SO_0000010

856940
type: Gene
SIO_000068: ncbigene

position:571480:1
position: 571480
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

position:576525:1
position: 576525
reference: sequence
type: ForwardStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:571480-576525:1:exon

YER190W
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-2
locus tag: YER190W
gene synonym: YRF1
product: Y' element ATP-dependent helicase protein 1 copy 2
transcript id: NM_001179080.3
SIO_010081: YER190W
subclass of: SO_0000673
so part of: YER190W
location: <571480..>576525
location: region:571480-576525:1
so has part: feature:571480-576525:1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:571480-576525:1:exon

YER190W
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
alternative label: YRF1
gene: YRF1-2
locus tag: YER190W
gene synonym: YRF1
EC number: 3.6.4.12
experiment: EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]
experiment: EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]
experiment: EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]
note: Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation
codon start: 1
product: Y' element ATP-dependent helicase protein 1 copy 2
translation: MVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEKASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNREYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLENDSFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYPELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQMQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRNFIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTSATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQLALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE
SIO_010081: YER190W
subclass of: SO_0000673
so part of: YER190W
location: 571480..576525
location: region:571480-576525:1
so has part: feature:571480-576525:1:exon

NP_011117.3
type: Protein
SIO_000068: ncbiprotein

S000000992
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:571480-576525:1:exon

YER190C-B
type: Gene
subclass of: SO_0000704
RO_0002162: 559292
locus tag: YER190C-B
so part of: sequence
location: complement(<575680..>576162)
location: region:575680-576162:-1
so has part: feature:575680-576162:-1:exon
subclass of: SO_0000010

4594642
type: Gene
SIO_000068: ncbigene

position:575680:-1
position: 575680
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

position:576162:-1
position: 576162
reference: sequence
type: ReverseStrandPosition
type: FuzzyPosition
type: ExactPosition

urn:…
SIO_000300: 1
SIO_000628: feature:575680-576162:-1:exon

YER190C-B
type: Messenger RNA
subclass of: SO_0000234
RO_0002162: 559292
locus tag: YER190C-B
product: uncharacterized protein
transcript id: NM_001184590.1
SIO_010081: YER190C-B
subclass of: SO_0000673
so part of: YER190C-B
location: complement(<575680..>576162)
location: region:575680-576162:-1
so has part: feature:575680-576162:-1:exon

urn:…
SIO_000300: 1
SIO_000628: feature:575680-576162:-1:exon

YER190C-B
type: Coding Sequence
subclass of: SO_0000316
RO_0002162: 559292
locus tag: YER190C-B
note: hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
codon start: 1
product: uncharacterized protein
translation: MMPAKLQLDVLRTLQSSARHGTQTLKNSNFLERFHKDRIVFCLPFFPALFFVPVQKVLQHLCLRFTQVAPYFIIQLFDLPSRHAENLAPLLASCRIQYTNCFSSSSNGQVPSIISLYLRVDLSPFYAKIFQISYRVPMIWLDVFQVFFVFLVISQHSLHS
SIO_010081: YER190C-B
subclass of: SO_0000673
so part of: YER190C-B
location: complement(575680..576162)
location: region:575680-576162:-1
so has part: feature:575680-576162:-1:exon

NP_001073292.1
type: Protein
SIO_000068: ncbiprotein

S000028627
type: SGD
SIO_000068: sgd

urn:…
SIO_000300: 1
SIO_000628: feature:575680-576162:-1:exon